id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274172-3dctmmfe	Lucas, Alexandra	In vivo and in vitro models of demyelinating diseases II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses	1978-07-15		.txt	text/plain	5403	247	48	To investigate the replication of measles in the other non-neural and neural continuous cell lines, monolayer cultures were inoculated at 32.5" and examined for cytopathology, virus production, and development of infectious centers. Fol-With vaccinia virus, combined cell-associResults from these studies focus attention on three salient findings: (1) The strains of measles and mouse hepatitis viruses used can readily become established in a persistent form of infection in cell lines of neural and non-neural origin; (2) almost invariably when the infection is of the persistent type, virus replication becomes thermosensitive due to unknown factors under host control; the virus progeny from persistent infections are themselves not thermolabile; and (3) among the many cell types tested a rat RN2-2 Schwannoma has the unique ability to discriminate between the prototype MHV, and the neurotropic variant, JHM, supporting the persistence of only the latter.	./cache/cord-274172-3dctmmfe.txt	./txt/cord-274172-3dctmmfe.txt