id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293635-36pmai6s	Held, Katherine S.	Differential roles of CCL2 and CCR2 in host defense to coronavirus infection	2004-11-24		.txt	text/plain	6726	312	55	The data shown in Fig. 2 indicate that CD4 + and CD8 + T cell infiltration into the CNS of infected CCL2 À/À and CCR2 À/À is dramatically reduced as compared to wild-type mice. In contrast to T cell trafficking, there was a similar reduction in the number of macrophages present within the brains in both CCL2 À/À and CCR2 À/À mice, indicating that both ligand and receptor are important in directing these cells into the CNS in response to MHV infection. This is consistent with an earlier study by our laboratory demonstrating that MHV infection of mice lacking CCL3 resulted in the retention of virus-specific cells in the CLN, and this was the result of impaired expression of chemokine receptors, including CXCR3 and CCR5 that greatly aids T cells in their ability to migrate to the brain (Trifilo et al., 2003) .	./cache/cord-293635-36pmai6s.txt	./txt/cord-293635-36pmai6s.txt