id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297712-yy4g5npi	Zhu, Xinyu	Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO	2016-12-13		.txt	text/plain	3284	190	57	Here, we demonstrate that nonstructural protein 5 (nsp5) of PDCoV, the 3C-like protease, significantly inhibits Sendai virus (SEV)-induced IFN-β production by targeting the NF-κB essential modulator (NEMO), confirmed by the diminished function of NEMO cleaved by PDCoV. A study published by our lab also demonstrated that nsp5, the 3C-like protease of porcine epidemic diarrhea virus (PEDV), which is classified into the Alphacoronavirus family, antagonizes IFN-β production by cleavage of NEMO . In this study, we reveal that nsp5 of PDCoV antagonizes the type I IFN signaling pathway through the cleavage of NEMO, a critical constituent of the IKK complex, thus representing a newly identified mechanism by which PDCoV evades the innate immune response. In contrast, TBK1induced activation of the IFN-β promoter was not affected by nsp5 (Fig. 3A) , suggesting that PDCoV nsp5 inhibits RIG-I/MDA5 signaling by targeting NEMO or other upstream proteins.	./cache/cord-297712-yy4g5npi.txt	./txt/cord-297712-yy4g5npi.txt