id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300372-h5g4z8ts	Kelvin, Alyson A.	Lack of Group X Secreted Phospholipase A(2) Increases Survival Following Pandemic H1N1 Influenza Infection	2014-04-01		.txt	text/plain	10489	533	52	Based on the central role of sPLA(2) enzymes as key initiators of inflammatory processes, we propose that activation of GX-sPLA(2) during H1N1pdm infection is an early step of pulmonary inflammation and its (Reviewer 2 Minor Comment 2) inhibition increases adaptive immunity and improves survival. Increased expression of immunoglobulin chain, lymphocyte differentiation, antigen processing genes and presence of CD3 þ T cells in the lungs of mice lacking GX-sPLA 2 after H1N1pdm infection Lack of GX-sPLA 2 resulted in decreased levels of PGD 2 , LTB 4 , cysteinyl leukotrienes, PGE 2 and Lipoxin A 4 and increased adaptive immune responses at 3 but not 6 days following H1N1pdm infection. MPO protein (neutrophil marker), CD45 protein (leukocyte marker) and GAPDH protein (loading control) expression levels were determined by immunoblot analysis from lung tissue homogenates of GX þ / þ and GX À / À mice over a 14 day time course of H1N1pdm influenza infection (Bi).	./cache/cord-300372-h5g4z8ts.txt	./txt/cord-300372-h5g4z8ts.txt