id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305143-mqd4ioj4	Zmasek, Christian M.	Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO)	2019-01-06		.txt	text/plain	7266	367	44	Coupled with their genome complexity and the availability of numerous complete genome sequences, this deep evolutionary history makes herpesviruses a tractable and informative model to study virus genome evolution at the levels of gene duplication and protein domain rearrangement. In addition, the gene tree for human herpesvirus uracil DNA glycosylases ( Fig. 1B ) precisely recapitulates the herpesvirus species tree (Fig. 1A) ; therefore, this protein family can be inferred to have evolved from a single common ancestor and without any gene duplications or domain rearrangements (see Table 2 for virus-specific gene names). Phylogenetic analysis of human herpesvirus DNA polymerase proteins, plus related proteins from selected mammalian herpesviruses, shows that, similar to the glycoprotein B family, DNA polymerases of the Herpesviride evolved without gene duplication.	./cache/cord-305143-mqd4ioj4.txt	./txt/cord-305143-mqd4ioj4.txt