id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310967-15mv5yx7	Morris, Vincent L.	Characterization of coronavirus JHM variants isolated from wistar furth rats with a viral-induced demyelinating disease	1989-03-31		.txt	text/plain	5838	301	56	One of these variants, ATIIf cord virus, which induced a chronic demyelinating disease in 2or 10-day-old intracerebrally inoculated Wistar Furth rats, had a deletion in the coding region of the peplomer glycoprotein mRNA. In this report, we investigated viral variants that arose in the CNS of rats with a JHM-induced demyelinating disease and studied the effect of alterations in their mRNAs. When lo-day-old rats were inoculated with ATllf brain virus or ATlIe brain virus, the rats developed a rapid encephalitis instead of the more chronic demyelinating disease that has previously been seen with wild-type parental JHM virus (Sorensen et al., 1980; Jackson et al., 1984) and was observed with ATIIf cord virus-injected rats. In contrast, when 2-day-old rats were inoculated with ATllf cord virus, the more chronic CNS disease resulted instead of the rapid encephalitis that has been reported for wild-type JHM (Sorensen et a/., 1980; Parham et a/., 1986) and was observed with the ATIIf brain virus variant.	./cache/cord-310967-15mv5yx7.txt	./txt/cord-310967-15mv5yx7.txt