id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312210-3x9s3g8n	Stoian, Ana	The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV)	2019-12-24		.txt	text/plain	3444	199	59	title: The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV) However, lung fibroblast-like cells, derived from the ANPEP KO PAM cultures, supported PDCoV infection to high levels. In this study, we investigated the role of pAPN as a receptor for PDCoV by evaluating the permissiveness of different cell populations derived from the lungs of ANPEP KO and wild-type (WT) pigs. Porcine alveolar macrophages (PAMs) from ANPEP KO and WT pigs were used to evaluate the permissiveness of cells for infection with PDCoV and TGEV. The results showed that PAMs from pigs lacking a functional ANPEP gene are resistant to TGEV and PDCoV infection. The results from this study showed no PDCoV infection of PAMs obtained from ANPEP KO pigs (see Fig. 1A ), which supports the observations of Wang et al.	./cache/cord-312210-3x9s3g8n.txt	./txt/cord-312210-3x9s3g8n.txt