id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319403-5qyc0wsz	Miura, Tanya A.	Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines	2007-12-01		.txt	text/plain	6621	390	52	Type I cells were productively infected with SDAV and RCoV-P, and both live virus and UV-inactivated virus induced mRNA and protein expression of three CXC chemokines: CINC-2, CINC-3, and LIX, which are neutrophil chemoattractants. Bronchial epithelial cells and alveolar type II cells express and secrete proinflammatory cytokines and chemokines in response to infection with respiratory viruses including respiratory syncytial virus, influenza A virus, and the SARS-associated coronavirus (SARS-CoV) Yen et al., 2006; Zhang et al., 2001) . In this study, cultures of rat alveolar type I cells were evaluated for susceptibility to RCoV infection, and for expression and secretion of proinflammatory cytokines and chemokines in response to RCoV inoculation. To determine whether the CXC chemokine response to infectious or UV-inactivated RCoV-P or SDAV was specific for the rat coronaviruses, we inoculated rat alveolar type I cells with a related group 2a coronavirus, mouse hepatitis virus (MHV) strain A59 that had been purified by sucrose density gradient centrifugation.	./cache/cord-319403-5qyc0wsz.txt	./txt/cord-319403-5qyc0wsz.txt