id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353748-y1a52z8e	Bhattacharya, Rajarshi	A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2	2021-01-02		.txt	text/plain	3308	211	61	title: A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2 Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor binding domain) of the SARS-CoV-2 spike protein. The present study attempts to investigate the ability of food-grade nisin A and its natural variants to block the interaction between hACE2 and the spike protein of SARS-CoV-2, a key step of COVID-19 disease initiation. The binding affinity of docked structures of all eight variants of nisin in complex with hACE2 was calculated as ΔG derived from analysis with Prodigy for each complex in comparison with the RBD of spike protein of SARS-CoV-2.	./cache/cord-353748-y1a52z8e.txt	./txt/cord-353748-y1a52z8e.txt