id sid tid token lemma pos cord-271526-14nfqusv 1 1 key key JJ cord-271526-14nfqusv 1 2 : : : cord-271526-14nfqusv 1 3 cord-271526 cord-271526 NN cord-271526-14nfqusv 1 4 - - HYPH cord-271526-14nfqusv 1 5 14nfqusv 14nfqusv CD cord-271526-14nfqusv 1 6 authors author NNS cord-271526-14nfqusv 1 7 : : : cord-271526-14nfqusv 1 8 Molenkamp Molenkamp NNP cord-271526-14nfqusv 1 9 , , , cord-271526-14nfqusv 1 10 Richard Richard NNP cord-271526-14nfqusv 1 11 ; ; : cord-271526-14nfqusv 1 12 Spaan Spaan NNP cord-271526-14nfqusv 1 13 , , , cord-271526-14nfqusv 1 14 Willy Willy NNP cord-271526-14nfqusv 1 15 J.M. J.M. NNP cord-271526-14nfqusv 1 16 title title NN cord-271526-14nfqusv 1 17 : : : cord-271526-14nfqusv 1 18 Identification identification NN cord-271526-14nfqusv 1 19 of of IN cord-271526-14nfqusv 1 20 a a DT cord-271526-14nfqusv 1 21 Specific specific JJ cord-271526-14nfqusv 1 22 Interaction Interaction NNP cord-271526-14nfqusv 1 23 between between IN cord-271526-14nfqusv 1 24 the the DT cord-271526-14nfqusv 1 25 Coronavirus Coronavirus NNP cord-271526-14nfqusv 1 26 Mouse Mouse NNP cord-271526-14nfqusv 1 27 Hepatitis Hepatitis NNP cord-271526-14nfqusv 1 28 Virus Virus NNP cord-271526-14nfqusv 1 29 A59 A59 NNP cord-271526-14nfqusv 1 30 Nucleocapsid Nucleocapsid NNP cord-271526-14nfqusv 1 31 Protein Protein NNP cord-271526-14nfqusv 1 32 and and CC cord-271526-14nfqusv 1 33 Packaging Packaging NNP cord-271526-14nfqusv 1 34 Signal Signal NNP cord-271526-14nfqusv 1 35 date date NN cord-271526-14nfqusv 1 36 : : : cord-271526-14nfqusv 1 37 1997 1997 CD cord-271526-14nfqusv 1 38 - - SYM cord-271526-14nfqusv 1 39 12 12 CD cord-271526-14nfqusv 1 40 - - HYPH cord-271526-14nfqusv 1 41 08 08 CD cord-271526-14nfqusv 1 42 journal journal NN cord-271526-14nfqusv 1 43 : : : cord-271526-14nfqusv 1 44 Virology Virology NNP cord-271526-14nfqusv 1 45 DOI DOI NNP cord-271526-14nfqusv 1 46 : : : cord-271526-14nfqusv 2 1 10.1006/ 10.1006/ LS cord-271526-14nfqusv 3 1 viro.1997.8867 viro.1997.8867 ADD cord-271526-14nfqusv 3 2 sha sha NNP cord-271526-14nfqusv 3 3 : : : cord-271526-14nfqusv 3 4 ed607974f6c3ea829cd36bd23d376880dcb26d2d ed607974f6c3ea829cd36bd23d376880dcb26d2d NNP cord-271526-14nfqusv 3 5 doc_id doc_id CD cord-271526-14nfqusv 3 6 : : : cord-271526-14nfqusv 3 7 271526 271526 CD cord-271526-14nfqusv 3 8 cord_uid cord_uid NNS cord-271526-14nfqusv 3 9 : : : cord-271526-14nfqusv 4 1 14nfqusv 14nfqusv CD cord-271526-14nfqusv 4 2 Abstract Abstract NNP cord-271526-14nfqusv 5 1 The the DT cord-271526-14nfqusv 5 2 coronavirus coronavirus NN cord-271526-14nfqusv 5 3 mouse mouse NN cord-271526-14nfqusv 5 4 hepatitis hepatitis NN cord-271526-14nfqusv 5 5 virus virus NN cord-271526-14nfqusv 5 6 ( ( -LRB- cord-271526-14nfqusv 5 7 MHV MHV NNP cord-271526-14nfqusv 5 8 ) ) -RRB- cord-271526-14nfqusv 5 9 is be VBZ cord-271526-14nfqusv 5 10 an an DT cord-271526-14nfqusv 5 11 enveloped envelop VBN cord-271526-14nfqusv 5 12 positive positive JJ cord-271526-14nfqusv 5 13 stranded strand VBN cord-271526-14nfqusv 5 14 RNA RNA NNP cord-271526-14nfqusv 5 15 virus virus NN cord-271526-14nfqusv 5 16 . . . cord-271526-14nfqusv 6 1 In in IN cord-271526-14nfqusv 6 2 infected infected JJ cord-271526-14nfqusv 6 3 cells cell NNS cord-271526-14nfqusv 6 4 MHV MHV NNP cord-271526-14nfqusv 6 5 produces produce VBZ cord-271526-14nfqusv 6 6 a a DT cord-271526-14nfqusv 6 7 3′ 3′ CD cord-271526-14nfqusv 6 8 coterminal coterminal NNP cord-271526-14nfqusv 6 9 nested nest VBN cord-271526-14nfqusv 6 10 set set NN cord-271526-14nfqusv 6 11 of of IN cord-271526-14nfqusv 6 12 subgenomic subgenomic NNP cord-271526-14nfqusv 6 13 messenger messenger NNP cord-271526-14nfqusv 6 14 RNAs RNAs NNP cord-271526-14nfqusv 6 15 . . . cord-271526-14nfqusv 7 1 Only only RB cord-271526-14nfqusv 7 2 the the DT cord-271526-14nfqusv 7 3 genomic genomic JJ cord-271526-14nfqusv 7 4 RNA rna NN cord-271526-14nfqusv 7 5 , , , cord-271526-14nfqusv 7 6 however however RB cord-271526-14nfqusv 7 7 , , , cord-271526-14nfqusv 7 8 is be VBZ cord-271526-14nfqusv 7 9 encapsidated encapsidate VBN cord-271526-14nfqusv 7 10 by by IN cord-271526-14nfqusv 7 11 the the DT cord-271526-14nfqusv 7 12 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 7 13 protein protein NNP cord-271526-14nfqusv 7 14 and and CC cord-271526-14nfqusv 7 15 incorporated incorporate VBN cord-271526-14nfqusv 7 16 in in IN cord-271526-14nfqusv 7 17 infectious infectious JJ cord-271526-14nfqusv 7 18 MHV MHV NNP cord-271526-14nfqusv 7 19 virions virion NNS cord-271526-14nfqusv 7 20 . . . cord-271526-14nfqusv 8 1 It -PRON- PRP cord-271526-14nfqusv 8 2 is be VBZ cord-271526-14nfqusv 8 3 believed believe VBN cord-271526-14nfqusv 8 4 that that IN cord-271526-14nfqusv 8 5 an an DT cord-271526-14nfqusv 8 6 RNA RNA NNP cord-271526-14nfqusv 8 7 packaging packaging NN cord-271526-14nfqusv 8 8 signal signal NN cord-271526-14nfqusv 8 9 ( ( -LRB- cord-271526-14nfqusv 8 10 Ps Ps NNP cord-271526-14nfqusv 8 11 ) ) -RRB- cord-271526-14nfqusv 8 12 , , , cord-271526-14nfqusv 8 13 present present JJ cord-271526-14nfqusv 8 14 only only RB cord-271526-14nfqusv 8 15 in in IN cord-271526-14nfqusv 8 16 the the DT cord-271526-14nfqusv 8 17 genomic genomic JJ cord-271526-14nfqusv 8 18 RNA RNA NNP cord-271526-14nfqusv 8 19 , , , cord-271526-14nfqusv 8 20 is be VBZ cord-271526-14nfqusv 8 21 responsible responsible JJ cord-271526-14nfqusv 8 22 for for IN cord-271526-14nfqusv 8 23 this this DT cord-271526-14nfqusv 8 24 selectivity selectivity NN cord-271526-14nfqusv 8 25 . . . cord-271526-14nfqusv 9 1 Earlier early JJR cord-271526-14nfqusv 9 2 studies study NNS cord-271526-14nfqusv 9 3 mapped map VBD cord-271526-14nfqusv 9 4 this this DT cord-271526-14nfqusv 9 5 signal signal NN cord-271526-14nfqusv 9 6 to to IN cord-271526-14nfqusv 9 7 a a DT cord-271526-14nfqusv 9 8 69-nt 69-nt CD cord-271526-14nfqusv 9 9 stem stem NN cord-271526-14nfqusv 9 10 – – : cord-271526-14nfqusv 9 11 loop loop NN cord-271526-14nfqusv 9 12 structure structure NN cord-271526-14nfqusv 9 13 positioned position VBN cord-271526-14nfqusv 9 14 in in IN cord-271526-14nfqusv 9 15 the the DT cord-271526-14nfqusv 9 16 3′ 3′ CD cord-271526-14nfqusv 9 17 end end NN cord-271526-14nfqusv 9 18 of of IN cord-271526-14nfqusv 9 19 ORF1b ORF1b NNP cord-271526-14nfqusv 9 20 . . . cord-271526-14nfqusv 10 1 The the DT cord-271526-14nfqusv 10 2 selective selective JJ cord-271526-14nfqusv 10 3 encapsidation encapsidation NN cord-271526-14nfqusv 10 4 mechanism mechanism NN cord-271526-14nfqusv 10 5 probably probably RB cord-271526-14nfqusv 10 6 initiates initiate VBZ cord-271526-14nfqusv 10 7 by by IN cord-271526-14nfqusv 10 8 specific specific JJ cord-271526-14nfqusv 10 9 interaction interaction NN cord-271526-14nfqusv 10 10 of of IN cord-271526-14nfqusv 10 11 the the DT cord-271526-14nfqusv 10 12 packaging packaging NN cord-271526-14nfqusv 10 13 signal signal NN cord-271526-14nfqusv 10 14 with with IN cord-271526-14nfqusv 10 15 the the DT cord-271526-14nfqusv 10 16 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 10 17 protein protein NN cord-271526-14nfqusv 10 18 . . . cord-271526-14nfqusv 11 1 In in IN cord-271526-14nfqusv 11 2 this this DT cord-271526-14nfqusv 11 3 study study NN cord-271526-14nfqusv 11 4 we -PRON- PRP cord-271526-14nfqusv 11 5 demonstrate demonstrate VBP cord-271526-14nfqusv 11 6 thein thein NNP cord-271526-14nfqusv 11 7 vitrointeraction vitrointeraction NNP cord-271526-14nfqusv 11 8 of of IN cord-271526-14nfqusv 11 9 the the DT cord-271526-14nfqusv 11 10 MHV MHV NNP cord-271526-14nfqusv 11 11 - - HYPH cord-271526-14nfqusv 11 12 A59 A59 NNP cord-271526-14nfqusv 11 13 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 11 14 protein protein NN cord-271526-14nfqusv 11 15 with with IN cord-271526-14nfqusv 11 16 the the DT cord-271526-14nfqusv 11 17 packaging packaging NN cord-271526-14nfqusv 11 18 signal signal NN cord-271526-14nfqusv 11 19 of of IN cord-271526-14nfqusv 11 20 MHV MHV NNP cord-271526-14nfqusv 11 21 using use VBG cord-271526-14nfqusv 11 22 gel gel NN cord-271526-14nfqusv 11 23 retardation retardation NN cord-271526-14nfqusv 11 24 and and CC cord-271526-14nfqusv 11 25 UV UV NNP cord-271526-14nfqusv 11 26 cross cross JJ cord-271526-14nfqusv 11 27 - - JJ cord-271526-14nfqusv 11 28 linking link VBG cord-271526-14nfqusv 11 29 assays assay NNS cord-271526-14nfqusv 11 30 . . . cord-271526-14nfqusv 12 1 This this DT cord-271526-14nfqusv 12 2 interaction interaction NN cord-271526-14nfqusv 12 3 was be VBD cord-271526-14nfqusv 12 4 observed observe VBN cord-271526-14nfqusv 12 5 not not RB cord-271526-14nfqusv 12 6 only only RB cord-271526-14nfqusv 12 7 with with IN cord-271526-14nfqusv 12 8 the the DT cord-271526-14nfqusv 12 9 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 12 10 protein protein NN cord-271526-14nfqusv 12 11 from from IN cord-271526-14nfqusv 12 12 infected infected JJ cord-271526-14nfqusv 12 13 cells cell NNS cord-271526-14nfqusv 12 14 but but CC cord-271526-14nfqusv 12 15 also also RB cord-271526-14nfqusv 12 16 with with IN cord-271526-14nfqusv 12 17 that that DT cord-271526-14nfqusv 12 18 from from IN cord-271526-14nfqusv 12 19 purified purify VBN cord-271526-14nfqusv 12 20 virions virion NNS cord-271526-14nfqusv 12 21 and and CC cord-271526-14nfqusv 12 22 from from IN cord-271526-14nfqusv 12 23 cells cell NNS cord-271526-14nfqusv 12 24 expressing express VBG cord-271526-14nfqusv 12 25 a a DT cord-271526-14nfqusv 12 26 recombinant recombinant JJ cord-271526-14nfqusv 12 27 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 12 28 protein protein NN cord-271526-14nfqusv 12 29 . . . cord-271526-14nfqusv 13 1 The the DT cord-271526-14nfqusv 13 2 specificity specificity NN cord-271526-14nfqusv 13 3 of of IN cord-271526-14nfqusv 13 4 the the DT cord-271526-14nfqusv 13 5 interaction interaction NN cord-271526-14nfqusv 13 6 was be VBD cord-271526-14nfqusv 13 7 demonstrated demonstrate VBN cord-271526-14nfqusv 13 8 by by IN cord-271526-14nfqusv 13 9 competition competition NN cord-271526-14nfqusv 13 10 experiments experiment NNS cord-271526-14nfqusv 13 11 with with IN cord-271526-14nfqusv 13 12 nonlabeled nonlabeled NNP cord-271526-14nfqusv 13 13 Ps Ps NNP cord-271526-14nfqusv 13 14 containing contain VBG cord-271526-14nfqusv 13 15 RNAs rna NNS cord-271526-14nfqusv 13 16 , , , cord-271526-14nfqusv 13 17 tRNA tRNA NNP cord-271526-14nfqusv 13 18 , , , cord-271526-14nfqusv 13 19 and and CC cord-271526-14nfqusv 13 20 total total JJ cord-271526-14nfqusv 13 21 cytoplasmic cytoplasmic JJ cord-271526-14nfqusv 13 22 RNA RNA NNP cord-271526-14nfqusv 13 23 . . . cord-271526-14nfqusv 14 1 The the DT cord-271526-14nfqusv 14 2 results result NNS cord-271526-14nfqusv 14 3 indicated indicate VBD cord-271526-14nfqusv 14 4 that that IN cord-271526-14nfqusv 14 5 no no DT cord-271526-14nfqusv 14 6 virus virus NN cord-271526-14nfqusv 14 7 specific specific JJ cord-271526-14nfqusv 14 8 modification modification NN cord-271526-14nfqusv 14 9 of of IN cord-271526-14nfqusv 14 10 the the DT cord-271526-14nfqusv 14 11 N n NN cord-271526-14nfqusv 14 12 - - HYPH cord-271526-14nfqusv 14 13 protein protein NN cord-271526-14nfqusv 14 14 or or CC cord-271526-14nfqusv 14 15 the the DT cord-271526-14nfqusv 14 16 presence presence NN cord-271526-14nfqusv 14 17 of of IN cord-271526-14nfqusv 14 18 other other JJ cord-271526-14nfqusv 14 19 viral viral JJ cord-271526-14nfqusv 14 20 proteins protein NNS cord-271526-14nfqusv 14 21 are be VBP cord-271526-14nfqusv 14 22 required require VBN cord-271526-14nfqusv 14 23 for for IN cord-271526-14nfqusv 14 24 thisin thisin NNP cord-271526-14nfqusv 14 25 vitrointeraction vitrointeraction NNP cord-271526-14nfqusv 14 26 . . . cord-271526-14nfqusv 15 1 The the DT cord-271526-14nfqusv 15 2 assays assay NNS cord-271526-14nfqusv 15 3 described describe VBN cord-271526-14nfqusv 15 4 in in IN cord-271526-14nfqusv 15 5 this this DT cord-271526-14nfqusv 15 6 report report NN cord-271526-14nfqusv 15 7 provide provide VB cord-271526-14nfqusv 15 8 us -PRON- PRP cord-271526-14nfqusv 15 9 with with IN cord-271526-14nfqusv 15 10 a a DT cord-271526-14nfqusv 15 11 powerful powerful JJ cord-271526-14nfqusv 15 12 tool tool NN cord-271526-14nfqusv 15 13 for for IN cord-271526-14nfqusv 15 14 studying study VBG cord-271526-14nfqusv 15 15 encapsidation encapsidation NN cord-271526-14nfqusv 15 16 ( ( -LRB- cord-271526-14nfqusv 15 17 initiation initiation NN cord-271526-14nfqusv 15 18 ) ) -RRB- cord-271526-14nfqusv 15 19 in in IN cord-271526-14nfqusv 15 20 more more JJR cord-271526-14nfqusv 15 21 detail detail NN cord-271526-14nfqusv 15 22 . . . cord-271526-14nfqusv 16 1 gion gion NNP cord-271526-14nfqusv 16 2 a a DT cord-271526-14nfqusv 16 3 domain domain NN cord-271526-14nfqusv 16 4 ( ( -LRB- cord-271526-14nfqusv 16 5 from from IN cord-271526-14nfqusv 16 6 here here RB cord-271526-14nfqusv 16 7 on on RB cord-271526-14nfqusv 16 8 called call VBN cord-271526-14nfqusv 16 9 Ps Ps NNP cord-271526-14nfqusv 16 10 ) ) -RRB- cord-271526-14nfqusv 16 11 of of IN cord-271526-14nfqusv 16 12 69 69 CD cord-271526-14nfqusv 16 13 nt nt RB cord-271526-14nfqusv 16 14 could could MD cord-271526-14nfqusv 16 15 be be VB cord-271526-14nfqusv 16 16 identified identify VBN cord-271526-14nfqusv 16 17 that that DT cord-271526-14nfqusv 16 18 is be VBZ cord-271526-14nfqusv 16 19 probably probably RB cord-271526-14nfqusv 16 20 required require VBN cord-271526-14nfqusv 16 21 for for IN cord-271526-14nfqusv 16 22 the the DT cord-271526-14nfqusv 16 23 encapsidation encapsidation NN cord-271526-14nfqusv 16 24 The the DT cord-271526-14nfqusv 16 25 murine murine JJ cord-271526-14nfqusv 16 26 coronavirus coronavirus NN cord-271526-14nfqusv 16 27 mouse mouse NN cord-271526-14nfqusv 16 28 hepatitis hepatitis NN cord-271526-14nfqusv 16 29 virus virus NN cord-271526-14nfqusv 16 30 ( ( -LRB- cord-271526-14nfqusv 16 31 MHV MHV NNP cord-271526-14nfqusv 16 32 ) ) -RRB- cord-271526-14nfqusv 16 33 of of IN cord-271526-14nfqusv 16 34 defective defective JJ cord-271526-14nfqusv 16 35 genomes genome NNS cord-271526-14nfqusv 16 36 ( ( -LRB- cord-271526-14nfqusv 16 37 Fosmire Fosmire NNP cord-271526-14nfqusv 16 38 et et NNP cord-271526-14nfqusv 16 39 al al NNP cord-271526-14nfqusv 16 40 . . NNP cord-271526-14nfqusv 16 41 , , , cord-271526-14nfqusv 16 42 1992 1992 CD cord-271526-14nfqusv 16 43 ) ) -RRB- cord-271526-14nfqusv 16 44 . . . cord-271526-14nfqusv 17 1 This this DT cord-271526-14nfqusv 17 2 signal signal NN cord-271526-14nfqusv 17 3 is be VBZ cord-271526-14nfqusv 17 4 an an DT cord-271526-14nfqusv 17 5 enveloped envelop VBN cord-271526-14nfqusv 17 6 virus virus NN cord-271526-14nfqusv 17 7 containing contain VBG cord-271526-14nfqusv 17 8 a a DT cord-271526-14nfqusv 17 9 positive positive JJ cord-271526-14nfqusv 17 10 stranded strand VBN cord-271526-14nfqusv 17 11 RNA RNA NNP cord-271526-14nfqusv 17 12 is be VBZ cord-271526-14nfqusv 17 13 present present JJ cord-271526-14nfqusv 17 14 in in IN cord-271526-14nfqusv 17 15 genomic genomic JJ cord-271526-14nfqusv 17 16 RNA RNA NNP cord-271526-14nfqusv 17 17 , , , cord-271526-14nfqusv 17 18 but but CC cord-271526-14nfqusv 17 19 not not RB cord-271526-14nfqusv 17 20 in in IN cord-271526-14nfqusv 17 21 sgRNAs sgrna NNS cord-271526-14nfqusv 18 1 and and CC cord-271526-14nfqusv 18 2 it -PRON- PRP cord-271526-14nfqusv 18 3 is be VBZ cord-271526-14nfqusv 18 4 genome genome NN cord-271526-14nfqusv 18 5 of of IN cord-271526-14nfqusv 18 6 about about RB cord-271526-14nfqusv 18 7 31 31 CD cord-271526-14nfqusv 18 8 kb kb NNP cord-271526-14nfqusv 18 9 ( ( -LRB- cord-271526-14nfqusv 18 10 Holmes Holmes NNP cord-271526-14nfqusv 18 11 , , , cord-271526-14nfqusv 18 12 1991 1991 CD cord-271526-14nfqusv 18 13 ; ; : cord-271526-14nfqusv 19 1 likely likely RB cord-271526-14nfqusv 19 2 that that IN cord-271526-14nfqusv 19 3 it -PRON- PRP cord-271526-14nfqusv 19 4 has have VBZ cord-271526-14nfqusv 19 5 also also RB cord-271526-14nfqusv 19 6 a a DT cord-271526-14nfqusv 19 7 similar similar JJ cord-271526-14nfqusv 19 8 function function NN cord-271526-14nfqusv 19 9 in in IN cord-271526-14nfqusv 19 10 the the DT cord-271526-14nfqusv 19 11 encapsida-1988 encapsida-1988 NNP cord-271526-14nfqusv 19 12 ) ) -RRB- cord-271526-14nfqusv 19 13 . . . cord-271526-14nfqusv 20 1 The the DT cord-271526-14nfqusv 20 2 virion virion NN cord-271526-14nfqusv 20 3 envelope envelope NN cord-271526-14nfqusv 20 4 is be VBZ cord-271526-14nfqusv 20 5 composed compose VBN cord-271526-14nfqusv 20 6 of of IN cord-271526-14nfqusv 20 7 a a DT cord-271526-14nfqusv 20 8 lipid lipid NN cord-271526-14nfqusv 20 9 bilayer bilayer NN cord-271526-14nfqusv 20 10 tion tion NN cord-271526-14nfqusv 20 11 of of IN cord-271526-14nfqusv 20 12 genomic genomic JJ cord-271526-14nfqusv 20 13 RNA RNA NNP cord-271526-14nfqusv 20 14 . . . cord-271526-14nfqusv 21 1 Recently recently RB cord-271526-14nfqusv 21 2 , , , cord-271526-14nfqusv 21 3 it -PRON- PRP cord-271526-14nfqusv 21 4 was be VBD cord-271526-14nfqusv 21 5 demonstrated demonstrate VBN cord-271526-14nfqusv 21 6 that that IN cord-271526-14nfqusv 21 7 derived derive VBN cord-271526-14nfqusv 21 8 from from IN cord-271526-14nfqusv 21 9 an an DT cord-271526-14nfqusv 21 10 internal internal JJ cord-271526-14nfqusv 21 11 compartment compartment NN cord-271526-14nfqusv 21 12 of of IN cord-271526-14nfqusv 21 13 the the DT cord-271526-14nfqusv 21 14 host host NN cord-271526-14nfqusv 21 15 cell cell NN cord-271526-14nfqusv 21 16 the the DT cord-271526-14nfqusv 21 17 encapsidation encapsidation NN cord-271526-14nfqusv 21 18 of of IN cord-271526-14nfqusv 21 19 a a DT cord-271526-14nfqusv 21 20 heterologous heterologous NNP cord-271526-14nfqusv 21 21 RNA RNA NNP cord-271526-14nfqusv 21 22 by by IN cord-271526-14nfqusv 21 23 MHV MHV NNP cord-271526-14nfqusv 21 24 was be VBD cord-271526-14nfqusv 21 25 and and CC cord-271526-14nfqusv 21 26 three three CD cord-271526-14nfqusv 21 27 or or CC cord-271526-14nfqusv 21 28 four four CD cord-271526-14nfqusv 21 29 virus virus NN cord-271526-14nfqusv 21 30 - - HYPH cord-271526-14nfqusv 21 31 encoded encode VBN cord-271526-14nfqusv 21 32 structural structural JJ cord-271526-14nfqusv 21 33 membrane membrane NN cord-271526-14nfqusv 21 34 fully fully RB cord-271526-14nfqusv 21 35 dependent dependent JJ cord-271526-14nfqusv 21 36 on on IN cord-271526-14nfqusv 21 37 the the DT cord-271526-14nfqusv 21 38 presence presence NN cord-271526-14nfqusv 21 39 of of IN cord-271526-14nfqusv 21 40 this this DT cord-271526-14nfqusv 21 41 Ps Ps NNP cord-271526-14nfqusv 21 42 ( ( -LRB- cord-271526-14nfqusv 21 43 Woo woo UH cord-271526-14nfqusv 21 44 et et FW cord-271526-14nfqusv 21 45 al al NNP cord-271526-14nfqusv 21 46 . . . cord-271526-14nfqusv 22 1 , , , cord-271526-14nfqusv 22 2 proteins protein NNS cord-271526-14nfqusv 22 3 ( ( -LRB- cord-271526-14nfqusv 22 4 Luytjes Luytjes NNP cord-271526-14nfqusv 22 5 , , , cord-271526-14nfqusv 22 6 1995 1995 CD cord-271526-14nfqusv 22 7 ) ) -RRB- cord-271526-14nfqusv 22 8 : : : cord-271526-14nfqusv 22 9 the the DT cord-271526-14nfqusv 22 10 spike spike NN cord-271526-14nfqusv 22 11 protein protein NN cord-271526-14nfqusv 22 12 ( ( -LRB- cord-271526-14nfqusv 22 13 S S NNP cord-271526-14nfqusv 22 14 ) ) -RRB- cord-271526-14nfqusv 22 15 , , , cord-271526-14nfqusv 22 16 the the DT cord-271526-14nfqusv 22 17 mem-1997 mem-1997 NN cord-271526-14nfqusv 22 18 ) ) -RRB- cord-271526-14nfqusv 22 19 . . . cord-271526-14nfqusv 23 1 Furthermore furthermore RB cord-271526-14nfqusv 23 2 , , , cord-271526-14nfqusv 23 3 it -PRON- PRP cord-271526-14nfqusv 23 4 was be VBD cord-271526-14nfqusv 23 5 shown show VBN cord-271526-14nfqusv 23 6 by by IN cord-271526-14nfqusv 23 7 Bos Bos NNP cord-271526-14nfqusv 23 8 et et NNP cord-271526-14nfqusv 23 9 al al NNP cord-271526-14nfqusv 23 10 . . . cord-271526-14nfqusv 24 1 ( ( -LRB- cord-271526-14nfqusv 24 2 1997 1997 CD cord-271526-14nfqusv 24 3 ) ) -RRB- cord-271526-14nfqusv 24 4 that that IN cord-271526-14nfqusv 24 5 brane brane NN cord-271526-14nfqusv 24 6 protein protein NN cord-271526-14nfqusv 24 7 ( ( -LRB- cord-271526-14nfqusv 24 8 M M NNP cord-271526-14nfqusv 24 9 ) ) -RRB- cord-271526-14nfqusv 24 10 , , , cord-271526-14nfqusv 24 11 the the DT cord-271526-14nfqusv 24 12 small small JJ cord-271526-14nfqusv 24 13 membrane membrane NN cord-271526-14nfqusv 24 14 protein protein NN cord-271526-14nfqusv 24 15 ( ( -LRB- cord-271526-14nfqusv 24 16 E E NNP cord-271526-14nfqusv 24 17 ) ) -RRB- cord-271526-14nfqusv 24 18 , , , cord-271526-14nfqusv 24 19 and and CC cord-271526-14nfqusv 24 20 transferring transfer VBG cord-271526-14nfqusv 24 21 the the DT cord-271526-14nfqusv 24 22 Ps Ps NNP cord-271526-14nfqusv 24 23 to to IN cord-271526-14nfqusv 24 24 a a DT cord-271526-14nfqusv 24 25 sgRNA sgrna NN cord-271526-14nfqusv 24 26 resulted result VBN cord-271526-14nfqusv 24 27 in in IN cord-271526-14nfqusv 24 28 the the DT cord-271526-14nfqusv 24 29 specific specific JJ cord-271526-14nfqusv 24 30 the the DT cord-271526-14nfqusv 24 31 optional optional JJ cord-271526-14nfqusv 24 32 hemagglutinin hemagglutinin NN cord-271526-14nfqusv 24 33 - - HYPH cord-271526-14nfqusv 24 34 esterase esterase NN cord-271526-14nfqusv 24 35 protein protein NN cord-271526-14nfqusv 24 36 ( ( -LRB- cord-271526-14nfqusv 24 37 HE HE NNP cord-271526-14nfqusv 24 38 ) ) -RRB- cord-271526-14nfqusv 24 39 . . . cord-271526-14nfqusv 25 1 The the DT cord-271526-14nfqusv 25 2 viencapsidation viencapsidation NN cord-271526-14nfqusv 25 3 of of IN cord-271526-14nfqusv 25 4 this this DT cord-271526-14nfqusv 25 5 sgRNA sgrna NN cord-271526-14nfqusv 25 6 , , , cord-271526-14nfqusv 25 7 though though IN cord-271526-14nfqusv 25 8 with with IN cord-271526-14nfqusv 25 9 reduced reduce VBN cord-271526-14nfqusv 25 10 effiral effiral JJ cord-271526-14nfqusv 25 11 envelope envelope NN cord-271526-14nfqusv 25 12 surrounds surround VBZ cord-271526-14nfqusv 25 13 a a DT cord-271526-14nfqusv 25 14 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 25 15 with with IN cord-271526-14nfqusv 25 16 helical helical JJ cord-271526-14nfqusv 25 17 symciency symciency NN cord-271526-14nfqusv 25 18 . . . cord-271526-14nfqusv 26 1 metry metry NNP cord-271526-14nfqusv 26 2 composed compose VBN cord-271526-14nfqusv 26 3 of of IN cord-271526-14nfqusv 26 4 the the DT cord-271526-14nfqusv 26 5 genomic genomic JJ cord-271526-14nfqusv 26 6 RNA RNA NNP cord-271526-14nfqusv 26 7 and and CC cord-271526-14nfqusv 26 8 multiple multiple JJ cord-271526-14nfqusv 26 9 copies copy NNS cord-271526-14nfqusv 27 1 The the DT cord-271526-14nfqusv 27 2 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 27 3 protein protein NN cord-271526-14nfqusv 27 4 of of IN cord-271526-14nfqusv 27 5 MHV MHV NNP cord-271526-14nfqusv 27 6 is be VBZ cord-271526-14nfqusv 27 7 a a DT cord-271526-14nfqusv 27 8 basic basic JJ cord-271526-14nfqusv 27 9 phosphoof phosphoof NN cord-271526-14nfqusv 27 10 the the DT cord-271526-14nfqusv 27 11 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 27 12 protein protein NNP cord-271526-14nfqusv 27 13 ( ( -LRB- cord-271526-14nfqusv 27 14 N N NNP cord-271526-14nfqusv 27 15 ) ) -RRB- cord-271526-14nfqusv 27 16 . . . cord-271526-14nfqusv 28 1 Evidence evidence NN cord-271526-14nfqusv 28 2 for for IN cord-271526-14nfqusv 28 3 the the DT cord-271526-14nfqusv 28 4 presprotein presprotein NN cord-271526-14nfqusv 28 5 of of IN cord-271526-14nfqusv 28 6 454 454 CD cord-271526-14nfqusv 28 7 amino amino JJ cord-271526-14nfqusv 28 8 acids acid NNS cord-271526-14nfqusv 28 9 and and CC cord-271526-14nfqusv 28 10 has have VBZ cord-271526-14nfqusv 28 11 an an DT cord-271526-14nfqusv 28 12 apparent apparent JJ cord-271526-14nfqusv 28 13 molecuence molecuence NN cord-271526-14nfqusv 28 14 of of IN cord-271526-14nfqusv 28 15 a a DT cord-271526-14nfqusv 28 16 fifth fifth JJ cord-271526-14nfqusv 28 17 structural structural JJ cord-271526-14nfqusv 28 18 envelope envelope NN cord-271526-14nfqusv 28 19 protein protein NN cord-271526-14nfqusv 28 20 translated translate VBN cord-271526-14nfqusv 28 21 from from IN cord-271526-14nfqusv 28 22 lar lar NNP cord-271526-14nfqusv 28 23 weight weight NN cord-271526-14nfqusv 28 24 of of IN cord-271526-14nfqusv 28 25 approximately approximately RB cord-271526-14nfqusv 28 26 55 55 CD cord-271526-14nfqusv 28 27 kDa kDa NNS cord-271526-14nfqusv 28 28 ( ( -LRB- cord-271526-14nfqusv 28 29 Armstrong Armstrong NNP cord-271526-14nfqusv 28 30 et et NNP cord-271526-14nfqusv 28 31 al al NNP cord-271526-14nfqusv 28 32 . . NNP cord-271526-14nfqusv 28 33 , , , cord-271526-14nfqusv 28 34 an an DT cord-271526-14nfqusv 28 35 internal internal JJ cord-271526-14nfqusv 28 36 open open JJ cord-271526-14nfqusv 28 37 reading reading NN cord-271526-14nfqusv 28 38 frame frame NN cord-271526-14nfqusv 28 39 ( ( -LRB- cord-271526-14nfqusv 28 40 ORF ORF NNP cord-271526-14nfqusv 28 41 ) ) -RRB- cord-271526-14nfqusv 28 42 within within IN cord-271526-14nfqusv 28 43 the the DT cord-271526-14nfqusv 28 44 N N NNP cord-271526-14nfqusv 28 45 gene gene NN cord-271526-14nfqusv 28 46 1983 1983 CD cord-271526-14nfqusv 28 47 ; ; : cord-271526-14nfqusv 28 48 Parker Parker NNP cord-271526-14nfqusv 28 49 and and CC cord-271526-14nfqusv 28 50 Masters Masters NNP cord-271526-14nfqusv 28 51 , , , cord-271526-14nfqusv 28 52 1990 1990 CD cord-271526-14nfqusv 28 53 ; ; : cord-271526-14nfqusv 28 54 Laude Laude NNP cord-271526-14nfqusv 28 55 and and CC cord-271526-14nfqusv 28 56 Masters Masters NNP cord-271526-14nfqusv 28 57 , , , cord-271526-14nfqusv 28 58 has have VBZ cord-271526-14nfqusv 28 59 been be VBN cord-271526-14nfqusv 28 60 published publish VBN cord-271526-14nfqusv 28 61 recently recently RB cord-271526-14nfqusv 28 62 ( ( -LRB- cord-271526-14nfqusv 28 63 Fischer Fischer NNP cord-271526-14nfqusv 28 64 et et NNP cord-271526-14nfqusv 28 65 al al NNP cord-271526-14nfqusv 28 66 . . NNP cord-271526-14nfqusv 28 67 , , , cord-271526-14nfqusv 28 68 1997 1997 CD cord-271526-14nfqusv 28 69 ( ( -LRB- cord-271526-14nfqusv 28 70 Fischer Fischer NNP cord-271526-14nfqusv 28 71 et et NNP cord-271526-14nfqusv 28 72 al al NNP cord-271526-14nfqusv 28 73 . . NNP cord-271526-14nfqusv 28 74 , , , cord-271526-14nfqusv 28 75 ) ) -RRB- cord-271526-14nfqusv 28 76 . . . cord-271526-14nfqusv 29 1 1995 1995 CD cord-271526-14nfqusv 29 2 . . . cord-271526-14nfqusv 30 1 It -PRON- PRP cord-271526-14nfqusv 30 2 is be VBZ cord-271526-14nfqusv 30 3 phosphorylated phosphorylate VBN cord-271526-14nfqusv 30 4 exclusively exclusively RB cord-271526-14nfqusv 30 5 on on IN cord-271526-14nfqusv 30 6 serine serine JJ cord-271526-14nfqusv 30 7 residues residue NNS cord-271526-14nfqusv 31 1 In in IN cord-271526-14nfqusv 31 2 infected infected JJ cord-271526-14nfqusv 31 3 cells cell NNS cord-271526-14nfqusv 31 4 MHV MHV NNP cord-271526-14nfqusv 31 5 produces produce VBZ cord-271526-14nfqusv 31 6 a a DT cord-271526-14nfqusv 31 7 3 3 CD cord-271526-14nfqusv 31 8 coterminal coterminal JJ cord-271526-14nfqusv 31 9 nested nest VBN cord-271526-14nfqusv 31 10 ( ( -LRB- cord-271526-14nfqusv 31 11 Stohlman Stohlman NNP cord-271526-14nfqusv 31 12 and and CC cord-271526-14nfqusv 31 13 Lai Lai NNP cord-271526-14nfqusv 31 14 , , , cord-271526-14nfqusv 31 15 1979 1979 CD cord-271526-14nfqusv 31 16 ) ) -RRB- cord-271526-14nfqusv 31 17 . . . cord-271526-14nfqusv 32 1 The the DT cord-271526-14nfqusv 32 2 N N NNP cord-271526-14nfqusv 32 3 protein protein NN cord-271526-14nfqusv 32 4 contains contain VBZ cord-271526-14nfqusv 32 5 41 41 CD cord-271526-14nfqusv 32 6 of of IN cord-271526-14nfqusv 32 7 set set NN cord-271526-14nfqusv 32 8 of of IN cord-271526-14nfqusv 32 9 subgenomic subgenomic NNP cord-271526-14nfqusv 32 10 mRNAs mRNAs . cord-271526-14nfqusv 33 1 ( ( -LRB- cord-271526-14nfqusv 33 2 sgRNAs sgRNAs NNP cord-271526-14nfqusv 33 3 ) ) -RRB- cord-271526-14nfqusv 33 4 which which WDT cord-271526-14nfqusv 33 5 possess possess VBP cord-271526-14nfqusv 33 6 an an DT cord-271526-14nfqusv 33 7 these these DT cord-271526-14nfqusv 33 8 potential potential JJ cord-271526-14nfqusv 33 9 phosphorylation phosphorylation NN cord-271526-14nfqusv 33 10 sites site NNS cord-271526-14nfqusv 33 11 , , , cord-271526-14nfqusv 33 12 but but CC cord-271526-14nfqusv 34 1 the the DT cord-271526-14nfqusv 34 2 exact exact JJ cord-271526-14nfqusv 34 3 numidentical numidentical JJ cord-271526-14nfqusv 34 4 5 5 CD cord-271526-14nfqusv 34 5 leader leader NN cord-271526-14nfqusv 34 6 sequence sequence NN cord-271526-14nfqusv 34 7 derived derive VBN cord-271526-14nfqusv 34 8 from from IN cord-271526-14nfqusv 34 9 the the DT cord-271526-14nfqusv 34 10 5 5 CD cord-271526-14nfqusv 34 11 end end NN cord-271526-14nfqusv 34 12 of of IN cord-271526-14nfqusv 34 13 ber ber NN cord-271526-14nfqusv 34 14 and and CC cord-271526-14nfqusv 34 15 location location NN cord-271526-14nfqusv 34 16 of of IN cord-271526-14nfqusv 34 17 phosphoserines phosphoserine NNS cord-271526-14nfqusv 34 18 have have VBP cord-271526-14nfqusv 34 19 not not RB cord-271526-14nfqusv 34 20 been be VBN cord-271526-14nfqusv 34 21 identithe identithe NNP cord-271526-14nfqusv 34 22 genome genome NN cord-271526-14nfqusv 35 1 ( ( -LRB- cord-271526-14nfqusv 35 2 Lai Lai NNP cord-271526-14nfqusv 35 3 et et FW cord-271526-14nfqusv 35 4 al al NNP cord-271526-14nfqusv 35 5 . . NNP cord-271526-14nfqusv 35 6 , , , cord-271526-14nfqusv 35 7 1984 1984 CD cord-271526-14nfqusv 35 8 ; ; : cord-271526-14nfqusv 35 9 Spaan Spaan NNP cord-271526-14nfqusv 35 10 et et FW cord-271526-14nfqusv 35 11 al al NNP cord-271526-14nfqusv 35 12 . . NNP cord-271526-14nfqusv 35 13 , , , cord-271526-14nfqusv 35 14 1983 1983 CD cord-271526-14nfqusv 36 1 Spaan Spaan NNP cord-271526-14nfqusv 36 2 et et FW cord-271526-14nfqusv 36 3 al al NNP cord-271526-14nfqusv 36 4 . . . cord-271526-14nfqusv 37 1 , , , cord-271526-14nfqusv 37 2 , , , cord-271526-14nfqusv 37 3 1988 1988 CD cord-271526-14nfqusv 37 4 . . . cord-271526-14nfqusv 38 1 fied fie VBN cord-271526-14nfqusv 38 2 yet yet RB cord-271526-14nfqusv 38 3 . . . cord-271526-14nfqusv 39 1 The the DT cord-271526-14nfqusv 39 2 basic basic JJ cord-271526-14nfqusv 39 3 amino amino NN cord-271526-14nfqusv 39 4 acids acid NNS cord-271526-14nfqusv 39 5 are be VBP cord-271526-14nfqusv 39 6 not not RB cord-271526-14nfqusv 39 7 clustered cluster VBN cord-271526-14nfqusv 39 8 in in IN cord-271526-14nfqusv 39 9 Only only JJ cord-271526-14nfqusv 39 10 genomic genomic JJ cord-271526-14nfqusv 39 11 length length NN cord-271526-14nfqusv 39 12 RNA RNA NNP cord-271526-14nfqusv 39 13 is be VBZ cord-271526-14nfqusv 39 14 packaged package VBN cord-271526-14nfqusv 39 15 into into IN cord-271526-14nfqusv 39 16 virus virus NN cord-271526-14nfqusv 39 17 partistrings partistring NNS cord-271526-14nfqusv 39 18 , , , cord-271526-14nfqusv 39 19 but but CC cord-271526-14nfqusv 39 20 local local JJ cord-271526-14nfqusv 39 21 densities density NNS cord-271526-14nfqusv 39 22 of of IN cord-271526-14nfqusv 39 23 positive positive JJ cord-271526-14nfqusv 39 24 charge charge NN cord-271526-14nfqusv 39 25 can can MD cord-271526-14nfqusv 39 26 be be VB cord-271526-14nfqusv 39 27 cles cles NNP cord-271526-14nfqusv 39 28 ; ; : cord-271526-14nfqusv 39 29 however however RB cord-271526-14nfqusv 39 30 , , , cord-271526-14nfqusv 39 31 trace trace NN cord-271526-14nfqusv 39 32 amounts amount NNS cord-271526-14nfqusv 39 33 of of IN cord-271526-14nfqusv 39 34 sg sg NNP cord-271526-14nfqusv 39 35 RNAs rna NNS cord-271526-14nfqusv 39 36 are be VBP cord-271526-14nfqusv 39 37 sometimes sometimes RB cord-271526-14nfqusv 39 38 found find VBN cord-271526-14nfqusv 39 39 , , , cord-271526-14nfqusv 39 40 particularly particularly RB cord-271526-14nfqusv 39 41 in in IN cord-271526-14nfqusv 39 42 two two CD cord-271526-14nfqusv 39 43 regions region NNS cord-271526-14nfqusv 39 44 in in IN cord-271526-14nfqusv 39 45 the the DT cord-271526-14nfqusv 39 46 middle middle NN cord-271526-14nfqusv 39 47 of of IN cord-271526-14nfqusv 39 48 the the DT cord-271526-14nfqusv 39 49 N N NNP cord-271526-14nfqusv 39 50 detected detect VBD cord-271526-14nfqusv 39 51 in in IN cord-271526-14nfqusv 39 52 purified purify VBN cord-271526-14nfqusv 39 53 virus virus NN cord-271526-14nfqusv 39 54 ( ( -LRB- cord-271526-14nfqusv 39 55 Makino Makino NNP cord-271526-14nfqusv 39 56 et et NNP cord-271526-14nfqusv 39 57 al al NNP cord-271526-14nfqusv 39 58 . . NNP cord-271526-14nfqusv 39 59 , , , cord-271526-14nfqusv 39 60 1988 1988 CD cord-271526-14nfqusv 39 61 ) ) -RRB- cord-271526-14nfqusv 39 62 . . . cord-271526-14nfqusv 40 1 Earlier early JJR cord-271526-14nfqusv 40 2 protein protein NN cord-271526-14nfqusv 40 3 ( ( -LRB- cord-271526-14nfqusv 40 4 Laude Laude NNP cord-271526-14nfqusv 40 5 and and CC cord-271526-14nfqusv 40 6 Masters Masters NNPS cord-271526-14nfqusv 40 7 , , , cord-271526-14nfqusv 40 8 1995 1995 CD cord-271526-14nfqusv 40 9 ) ) -RRB- cord-271526-14nfqusv 40 10 . . . cord-271526-14nfqusv 41 1 In in IN cord-271526-14nfqusv 41 2 contrast contrast NN cord-271526-14nfqusv 41 3 , , , cord-271526-14nfqusv 41 4 the the DT cord-271526-14nfqusv 41 5 Cstudies Cstudies NNP cord-271526-14nfqusv 41 6 ( ( -LRB- cord-271526-14nfqusv 41 7 Fosmire Fosmire NNP cord-271526-14nfqusv 41 8 et et NNP cord-271526-14nfqusv 41 9 al al NNP cord-271526-14nfqusv 41 10 . . NNP cord-271526-14nfqusv 41 11 , , , cord-271526-14nfqusv 41 12 1992 1992 CD cord-271526-14nfqusv 41 13 ; ; : cord-271526-14nfqusv 41 14 Most Most JJS cord-271526-14nfqusv 41 15 et et FW cord-271526-14nfqusv 41 16 al al NNP cord-271526-14nfqusv 41 17 . . NNP cord-271526-14nfqusv 41 18 , , , cord-271526-14nfqusv 41 19 1991 1991 CD cord-271526-14nfqusv 41 20 ) ) -RRB- cord-271526-14nfqusv 41 21 have have VBP cord-271526-14nfqusv 41 22 terminus terminus NN cord-271526-14nfqusv 41 23 is be VBZ cord-271526-14nfqusv 41 24 quite quite RB cord-271526-14nfqusv 41 25 acidic acidic JJ cord-271526-14nfqusv 41 26 . . . cord-271526-14nfqusv 42 1 The the DT cord-271526-14nfqusv 42 2 MHV MHV NNP cord-271526-14nfqusv 42 3 N N NNP cord-271526-14nfqusv 42 4 protein protein NN cord-271526-14nfqusv 42 5 does do VBZ cord-271526-14nfqusv 42 6 not not RB cord-271526-14nfqusv 42 7 mapped map VBN cord-271526-14nfqusv 42 8 a a DT cord-271526-14nfqusv 42 9 region region NN cord-271526-14nfqusv 42 10 in in IN cord-271526-14nfqusv 42 11 the the DT cord-271526-14nfqusv 42 12 3 3 CD cord-271526-14nfqusv 42 13 end end NN cord-271526-14nfqusv 42 14 of of IN cord-271526-14nfqusv 42 15 ORF1b ORF1b NNP cord-271526-14nfqusv 42 16 that that WDT cord-271526-14nfqusv 42 17 is be VBZ cord-271526-14nfqusv 42 18 essential essential JJ cord-271526-14nfqusv 43 1 contain contain VB cord-271526-14nfqusv 43 2 known know VBN cord-271526-14nfqusv 43 3 RNA rna NN cord-271526-14nfqusv 43 4 binding binding NN cord-271526-14nfqusv 43 5 motifs motif NNS cord-271526-14nfqusv 43 6 , , , cord-271526-14nfqusv 43 7 like like IN cord-271526-14nfqusv 43 8 the the DT cord-271526-14nfqusv 43 9 arginine arginine NN cord-271526-14nfqusv 43 10 - - HYPH cord-271526-14nfqusv 43 11 rich rich JJ cord-271526-14nfqusv 43 12 for for IN cord-271526-14nfqusv 43 13 encapsidation encapsidation NN cord-271526-14nfqusv 43 14 of of IN cord-271526-14nfqusv 43 15 defective defective JJ cord-271526-14nfqusv 43 16 genomes genome NNS cord-271526-14nfqusv 43 17 . . . cord-271526-14nfqusv 44 1 Within within IN cord-271526-14nfqusv 44 2 this this DT cord-271526-14nfqusv 44 3 remotif remotif NN cord-271526-14nfqusv 44 4 ( ( -LRB- cord-271526-14nfqusv 44 5 ARM arm NN cord-271526-14nfqusv 44 6 ) ) -RRB- cord-271526-14nfqusv 44 7 or or CC cord-271526-14nfqusv 44 8 zinc zinc NN cord-271526-14nfqusv 44 9 fingers finger NNS cord-271526-14nfqusv 44 10 ( ( -LRB- cord-271526-14nfqusv 44 11 Draper Draper NNP cord-271526-14nfqusv 44 12 , , , cord-271526-14nfqusv 44 13 1995 1995 CD cord-271526-14nfqusv 44 14 ; ; : cord-271526-14nfqusv 44 15 Holmes Holmes NNP cord-271526-14nfqusv 44 16 and and CC cord-271526-14nfqusv 44 17 Behnke Behnke NNP cord-271526-14nfqusv 44 18 , , , cord-271526-14nfqusv 44 19 1981 1981 CD cord-271526-14nfqusv 44 20 ; ; : cord-271526-14nfqusv 44 21 Burd Burd NNP cord-271526-14nfqusv 44 22 and and CC cord-271526-14nfqusv 44 23 Dreyfuss Dreyfuss NNP cord-271526-14nfqusv 44 24 , , , cord-271526-14nfqusv 44 25 1994 1994 CD cord-271526-14nfqusv 44 26 ) ) -RRB- cord-271526-14nfqusv 44 27 . . . cord-271526-14nfqusv 45 1 leader leader NN cord-271526-14nfqusv 45 2 RNA RNA NNP cord-271526-14nfqusv 45 3 has have VBZ cord-271526-14nfqusv 45 4 been be VBN cord-271526-14nfqusv 45 5 reported report VBN cord-271526-14nfqusv 45 6 although although IN cord-271526-14nfqusv 45 7 there there EX cord-271526-14nfqusv 45 8 is be VBZ cord-271526-14nfqusv 45 9 some some DT cord-271526-14nfqusv 45 10 analysis analysis NN cord-271526-14nfqusv 45 11 . . . cord-271526-14nfqusv 46 1 All all DT cord-271526-14nfqusv 46 2 enzyme enzyme NN cord-271526-14nfqusv 46 3 incubations incubation NNS cord-271526-14nfqusv 46 4 and and CC cord-271526-14nfqusv 46 5 biochemical biochemical JJ cord-271526-14nfqusv 46 6 reactions reaction NNS cord-271526-14nfqusv 46 7 were be VBD cord-271526-14nfqusv 46 8 performed perform VBN cord-271526-14nfqusv 46 9 according accord VBG cord-271526-14nfqusv 46 10 to to IN cord-271526-14nfqusv 46 11 the the DT cord-271526-14nfqusv 46 12 instructions instruction NNS cord-271526-14nfqusv 46 13 of of IN cord-271526-14nfqusv 46 14 the the DT cord-271526-14nfqusv 46 15 discrepancy discrepancy NN cord-271526-14nfqusv 46 16 about about IN cord-271526-14nfqusv 46 17 the the DT cord-271526-14nfqusv 46 18 specificity specificity NN cord-271526-14nfqusv 46 19 of of IN cord-271526-14nfqusv 46 20 this this DT cord-271526-14nfqusv 46 21 interaction interaction NN cord-271526-14nfqusv 46 22 ( ( -LRB- cord-271526-14nfqusv 46 23 Stohlman Stohlman NNP cord-271526-14nfqusv 46 24 et et NNP cord-271526-14nfqusv 46 25 al al NNP cord-271526-14nfqusv 46 26 . . NNP cord-271526-14nfqusv 46 27 , , , cord-271526-14nfqusv 46 28 1988 1988 CD cord-271526-14nfqusv 46 29 ; ; : cord-271526-14nfqusv 46 30 Bredenbeek Bredenbeek NNP cord-271526-14nfqusv 46 31 , , , cord-271526-14nfqusv 46 32 1990 1990 CD cord-271526-14nfqusv 46 33 ) ) -RRB- cord-271526-14nfqusv 46 34 . . . cord-271526-14nfqusv 47 1 A a DT cord-271526-14nfqusv 47 2 leader leader NN cord-271526-14nfqusv 47 3 - - HYPH cord-271526-14nfqusv 47 4 RNA RNA NNP cord-271526-14nfqusv 47 5 manufacturers manufacturer NNS cord-271526-14nfqusv 47 6 . . . cord-271526-14nfqusv 48 1 binding bind VBG cord-271526-14nfqusv 48 2 domain domain NN cord-271526-14nfqusv 48 3 in in IN cord-271526-14nfqusv 48 4 the the DT cord-271526-14nfqusv 48 5 N N NNP cord-271526-14nfqusv 48 6 protein protein NN cord-271526-14nfqusv 48 7 was be VBD cord-271526-14nfqusv 48 8 mapped map VBN cord-271526-14nfqusv 48 9 and and CC cord-271526-14nfqusv 48 10 com com NN cord-271526-14nfqusv 48 11 - - HYPH cord-271526-14nfqusv 48 12 Construction construction NN cord-271526-14nfqusv 48 13 of of IN cord-271526-14nfqusv 48 14 plasmids plasmid NNS cord-271526-14nfqusv 48 15 prises prise NNS cord-271526-14nfqusv 48 16 the the DT cord-271526-14nfqusv 48 17 two two CD cord-271526-14nfqusv 48 18 basic basic JJ cord-271526-14nfqusv 48 19 regions region NNS cord-271526-14nfqusv 48 20 mentioned mention VBN cord-271526-14nfqusv 48 21 above above RB cord-271526-14nfqusv 48 22 ( ( -LRB- cord-271526-14nfqusv 48 23 Nelson Nelson NNP cord-271526-14nfqusv 48 24 and and CC cord-271526-14nfqusv 48 25 Stohlman Stohlman NNP cord-271526-14nfqusv 48 26 , , , cord-271526-14nfqusv 48 27 1993 1993 CD cord-271526-14nfqusv 48 28 ; ; : cord-271526-14nfqusv 48 29 Masters Masters NNPS cord-271526-14nfqusv 48 30 , , , cord-271526-14nfqusv 48 31 1992 1992 CD cord-271526-14nfqusv 48 32 ) ) -RRB- cord-271526-14nfqusv 48 33 . . . cord-271526-14nfqusv 49 1 Furthermore furthermore RB cord-271526-14nfqusv 49 2 , , , cord-271526-14nfqusv 49 3 spe-(i spe-(i ADD cord-271526-14nfqusv 49 4 ) ) -RRB- cord-271526-14nfqusv 49 5 pPs290 pPs290 NNP cord-271526-14nfqusv 49 6 . . . cord-271526-14nfqusv 50 1 A a DT cord-271526-14nfqusv 50 2 204-nt 204-nt CD cord-271526-14nfqusv 50 3 fragment fragment NN cord-271526-14nfqusv 50 4 containing contain VBG cord-271526-14nfqusv 50 5 Ps Ps NNP cord-271526-14nfqusv 50 6 was be VBD cord-271526-14nfqusv 50 7 obcific obcific JJ cord-271526-14nfqusv 50 8 interaction interaction NN cord-271526-14nfqusv 50 9 of of IN cord-271526-14nfqusv 50 10 the the DT cord-271526-14nfqusv 50 11 coronavirus coronavirus NN cord-271526-14nfqusv 50 12 infectious infectious JJ cord-271526-14nfqusv 50 13 bronchitis bronchitis NN cord-271526-14nfqusv 50 14 tained taine VBN cord-271526-14nfqusv 50 15 by by IN cord-271526-14nfqusv 50 16 polymerase polymerase NN cord-271526-14nfqusv 50 17 chain chain NN cord-271526-14nfqusv 50 18 reaction reaction NN cord-271526-14nfqusv 50 19 ( ( -LRB- cord-271526-14nfqusv 50 20 PCR PCR NNP cord-271526-14nfqusv 50 21 ) ) -RRB- cord-271526-14nfqusv 50 22 using use VBG cord-271526-14nfqusv 50 23 pMIDIvirus pMIDIvirus NNP cord-271526-14nfqusv 50 24 ( ( -LRB- cord-271526-14nfqusv 50 25 IBV IBV NNP cord-271526-14nfqusv 50 26 ) ) -RRB- cord-271526-14nfqusv 50 27 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 50 28 protein protein NN cord-271526-14nfqusv 50 29 with with IN cord-271526-14nfqusv 50 30 the the DT cord-271526-14nfqusv 50 31 3 3 CD cord-271526-14nfqusv 50 32 terminus terminus NN cord-271526-14nfqusv 50 33 of of IN cord-271526-14nfqusv 50 34 C C NNP cord-271526-14nfqusv 50 35 as as IN cord-271526-14nfqusv 50 36 a a DT cord-271526-14nfqusv 50 37 template template NN cord-271526-14nfqusv 50 38 ( ( -LRB- cord-271526-14nfqusv 50 39 Most Most JJS cord-271526-14nfqusv 50 40 et et FW cord-271526-14nfqusv 50 41 al al NNP cord-271526-14nfqusv 50 42 . . NNP cord-271526-14nfqusv 50 43 , , , cord-271526-14nfqusv 50 44 1991 1991 CD cord-271526-14nfqusv 50 45 ) ) -RRB- cord-271526-14nfqusv 50 46 and and CC cord-271526-14nfqusv 50 47 oligonucleotide oligonucleotide IN cord-271526-14nfqusv 50 48 the the DT cord-271526-14nfqusv 50 49 genome genome NN cord-271526-14nfqusv 50 50 has have VBZ cord-271526-14nfqusv 50 51 recently recently RB cord-271526-14nfqusv 50 52 been be VBN cord-271526-14nfqusv 50 53 reported report VBN cord-271526-14nfqusv 51 1 ( ( -LRB- cord-271526-14nfqusv 51 2 Zhou Zhou NNP cord-271526-14nfqusv 51 3 et et NNP cord-271526-14nfqusv 51 4 al al NNP cord-271526-14nfqusv 51 5 . . NNP cord-271526-14nfqusv 51 6 , , , cord-271526-14nfqusv 51 7 primers primer NNS cord-271526-14nfqusv 51 8 C060 C060 NNPS cord-271526-14nfqusv 51 9 and and CC cord-271526-14nfqusv 51 10 C061 C061 NNS cord-271526-14nfqusv 52 1 ( ( -LRB- cord-271526-14nfqusv 52 2 Table table NN cord-271526-14nfqusv 52 3 1 1 CD cord-271526-14nfqusv 52 4 ) ) -RRB- cord-271526-14nfqusv 52 5 . . . cord-271526-14nfqusv 53 1 To to TO cord-271526-14nfqusv 53 2 obtain obtain VB cord-271526-14nfqusv 53 3 pPs290 pPs290 NNP cord-271526-14nfqusv 53 4 this this DT cord-271526-14nfqusv 53 5 1997 1997 CD cord-271526-14nfqusv 53 6 ) ) -RRB- cord-271526-14nfqusv 53 7 . . . cord-271526-14nfqusv 54 1 fragment fragment NN cord-271526-14nfqusv 54 2 was be VBD cord-271526-14nfqusv 54 3 cloned clone VBN cord-271526-14nfqusv 54 4 in in IN cord-271526-14nfqusv 54 5 pCRII pCRII NNP cord-271526-14nfqusv 54 6 using use VBG cord-271526-14nfqusv 54 7 the the DT cord-271526-14nfqusv 54 8 TA TA NNP cord-271526-14nfqusv 54 9 cloning cloning NN cord-271526-14nfqusv 54 10 kit kit NN cord-271526-14nfqusv 55 1 The the DT cord-271526-14nfqusv 55 2 69-nt 69-nt CD cord-271526-14nfqusv 56 1 Ps Ps NNP cord-271526-14nfqusv 56 2 is be VBZ cord-271526-14nfqusv 56 3 able able JJ cord-271526-14nfqusv 56 4 to to TO cord-271526-14nfqusv 56 5 form form VB cord-271526-14nfqusv 56 6 a a DT cord-271526-14nfqusv 56 7 stable stable JJ cord-271526-14nfqusv 56 8 secondary secondary JJ cord-271526-14nfqusv 56 9 struc-(Invitrogen struc-(invitrogen NN cord-271526-14nfqusv 56 10 ) ) -RRB- cord-271526-14nfqusv 56 11 according accord VBG cord-271526-14nfqusv 56 12 to to IN cord-271526-14nfqusv 56 13 the the DT cord-271526-14nfqusv 56 14 instructions instruction NNS cord-271526-14nfqusv 56 15 of of IN cord-271526-14nfqusv 56 16 the the DT cord-271526-14nfqusv 56 17 manufacture manufacture NN cord-271526-14nfqusv 56 18 and and CC cord-271526-14nfqusv 56 19 the the DT cord-271526-14nfqusv 56 20 integrity integrity NN cord-271526-14nfqusv 56 21 of of IN cord-271526-14nfqusv 56 22 this this DT cord-271526-14nfqusv 56 23 structure structure NN cord-271526-14nfqusv 56 24 is be VBZ cord-271526-14nfqusv 56 25 essential essential JJ cord-271526-14nfqusv 56 26 for for IN cord-271526-14nfqusv 56 27 turer turer NN cord-271526-14nfqusv 56 28 . . . cord-271526-14nfqusv 57 1 the the DT cord-271526-14nfqusv 57 2 encapsidation encapsidation NN cord-271526-14nfqusv 57 3 of of IN cord-271526-14nfqusv 57 4 defective defective JJ cord-271526-14nfqusv 57 5 genomes genome NNS cord-271526-14nfqusv 57 6 ( ( -LRB- cord-271526-14nfqusv 57 7 Fosmire Fosmire NNP cord-271526-14nfqusv 57 8 et et NNP cord-271526-14nfqusv 57 9 al al NNP cord-271526-14nfqusv 57 10 . . . cord-271526-14nfqusv 58 1 , , , cord-271526-14nfqusv 58 2 ( ( -LRB- cord-271526-14nfqusv 58 3 ii ii NN cord-271526-14nfqusv 58 4 ) ) -RRB- cord-271526-14nfqusv 59 1 pEMCV pEMCV NNP cord-271526-14nfqusv 59 2 - - HYPH cord-271526-14nfqusv 59 3 N. N. NNP cord-271526-14nfqusv 59 4 A A NNP cord-271526-14nfqusv 59 5 NcoI NcoI NNP cord-271526-14nfqusv 59 6 restriction restriction NN cord-271526-14nfqusv 59 7 site site NN cord-271526-14nfqusv 59 8 was be VBD cord-271526-14nfqusv 59 9 created create VBN cord-271526-14nfqusv 59 10 at at IN cord-271526-14nfqusv 59 11 1992 1992 CD cord-271526-14nfqusv 59 12 ) ) -RRB- cord-271526-14nfqusv 59 13 . . . cord-271526-14nfqusv 60 1 It -PRON- PRP cord-271526-14nfqusv 60 2 has have VBZ cord-271526-14nfqusv 60 3 been be VBN cord-271526-14nfqusv 60 4 postulated postulate VBN cord-271526-14nfqusv 60 5 ( ( -LRB- cord-271526-14nfqusv 60 6 Fosmire Fosmire NNP cord-271526-14nfqusv 60 7 et et NNP cord-271526-14nfqusv 60 8 al al NNP cord-271526-14nfqusv 60 9 . . NNP cord-271526-14nfqusv 60 10 , , , cord-271526-14nfqusv 60 11 1992 1992 CD cord-271526-14nfqusv 60 12 ) ) -RRB- cord-271526-14nfqusv 60 13 that that IN cord-271526-14nfqusv 60 14 the the DT cord-271526-14nfqusv 60 15 position position NN cord-271526-14nfqusv 60 16 of of IN cord-271526-14nfqusv 60 17 the the DT cord-271526-14nfqusv 60 18 AUG AUG NNP cord-271526-14nfqusv 60 19 start start NN cord-271526-14nfqusv 60 20 codon codon NN cord-271526-14nfqusv 60 21 of of IN cord-271526-14nfqusv 60 22 the the DT cord-271526-14nfqusv 60 23 N n CD cord-271526-14nfqusv 60 24 gene gene NN cord-271526-14nfqusv 60 25 by by IN cord-271526-14nfqusv 60 26 the the DT cord-271526-14nfqusv 60 27 Ps Ps NNP cord-271526-14nfqusv 60 28 functions function NNS cord-271526-14nfqusv 60 29 as as IN cord-271526-14nfqusv 60 30 an an DT cord-271526-14nfqusv 60 31 encapsidation encapsidation NN cord-271526-14nfqusv 60 32 initiation initiation NN cord-271526-14nfqusv 60 33 site site NN cord-271526-14nfqusv 60 34 , , , cord-271526-14nfqusv 60 35 prob prob NNP cord-271526-14nfqusv 60 36 - - HYPH cord-271526-14nfqusv 60 37 PCR pcr NN cord-271526-14nfqusv 60 38 mutagenesis mutagenesis NN cord-271526-14nfqusv 60 39 using use VBG cord-271526-14nfqusv 60 40 oligonucleotide oligonucleotide JJ cord-271526-14nfqusv 60 41 primers primer NNS cord-271526-14nfqusv 60 42 C261 C261 NNS cord-271526-14nfqusv 60 43 ably ably RB cord-271526-14nfqusv 60 44 by by IN cord-271526-14nfqusv 60 45 interacting interact VBG cord-271526-14nfqusv 60 46 specifically specifically RB cord-271526-14nfqusv 60 47 with with IN cord-271526-14nfqusv 60 48 the the DT cord-271526-14nfqusv 60 49 N N NNP cord-271526-14nfqusv 60 50 protein protein NN cord-271526-14nfqusv 60 51 . . . cord-271526-14nfqusv 61 1 Initiaand Initiaand NNP cord-271526-14nfqusv 61 2 C224 C224 NNP cord-271526-14nfqusv 61 3 ( ( -LRB- cord-271526-14nfqusv 61 4 Table Table NNP cord-271526-14nfqusv 61 5 1 1 CD cord-271526-14nfqusv 61 6 ) ) -RRB- cord-271526-14nfqusv 61 7 . . . cord-271526-14nfqusv 62 1 The the DT cord-271526-14nfqusv 62 2 PCR PCR NNP cord-271526-14nfqusv 62 3 fragment fragment NN cord-271526-14nfqusv 62 4 was be VBD cord-271526-14nfqusv 62 5 digested digest VBN cord-271526-14nfqusv 62 6 with with IN cord-271526-14nfqusv 62 7 tion tion NN cord-271526-14nfqusv 62 8 of of IN cord-271526-14nfqusv 62 9 encapsidation encapsidation NN cord-271526-14nfqusv 62 10 by by IN cord-271526-14nfqusv 62 11 packaging package VBG cord-271526-14nfqusv 62 12 signal/(nucleo)capsid signal/(nucleo)capsid NN cord-271526-14nfqusv 62 13 NcoI NcoI NNP cord-271526-14nfqusv 62 14 and and CC cord-271526-14nfqusv 62 15 ApaI ApaI NNP cord-271526-14nfqusv 62 16 and and CC cord-271526-14nfqusv 62 17 fused fuse VBD cord-271526-14nfqusv 62 18 to to IN cord-271526-14nfqusv 62 19 the the DT cord-271526-14nfqusv 62 20 remaining remain VBG cord-271526-14nfqusv 62 21 3 3 CD cord-271526-14nfqusv 62 22 sequences sequence NNS cord-271526-14nfqusv 62 23 protein protein NN cord-271526-14nfqusv 62 24 interactions interaction NNS cord-271526-14nfqusv 62 25 has have VBZ cord-271526-14nfqusv 62 26 been be VBN cord-271526-14nfqusv 62 27 observed observe VBN cord-271526-14nfqusv 62 28 for for IN cord-271526-14nfqusv 62 29 several several JJ cord-271526-14nfqusv 62 30 other other JJ cord-271526-14nfqusv 62 31 of of IN cord-271526-14nfqusv 62 32 the the DT cord-271526-14nfqusv 62 33 N n CD cord-271526-14nfqusv 62 34 gene gene NN cord-271526-14nfqusv 62 35 . . . cord-271526-14nfqusv 63 1 A a DT cord-271526-14nfqusv 63 2 consequence consequence NN cord-271526-14nfqusv 63 3 of of IN cord-271526-14nfqusv 63 4 this this DT cord-271526-14nfqusv 63 5 procedure procedure NN cord-271526-14nfqusv 63 6 was be VBD cord-271526-14nfqusv 63 7 RNA RNA NNP cord-271526-14nfqusv 63 8 viruses virus NNS cord-271526-14nfqusv 63 9 , , , cord-271526-14nfqusv 63 10 including include VBG cord-271526-14nfqusv 63 11 alphaviruses alphavirus NNS cord-271526-14nfqusv 63 12 , , , cord-271526-14nfqusv 63 13 retroviruses retrovirus NNS cord-271526-14nfqusv 63 14 , , , cord-271526-14nfqusv 63 15 and and CC cord-271526-14nfqusv 63 16 that that IN cord-271526-14nfqusv 63 17 the the DT cord-271526-14nfqusv 63 18 second second JJ cord-271526-14nfqusv 63 19 amino amino NN cord-271526-14nfqusv 63 20 acid acid NN cord-271526-14nfqusv 63 21 of of IN cord-271526-14nfqusv 63 22 the the DT cord-271526-14nfqusv 63 23 N N NNP cord-271526-14nfqusv 63 24 protein protein NN cord-271526-14nfqusv 63 25 was be VBD cord-271526-14nfqusv 63 26 changed change VBN cord-271526-14nfqusv 63 27 Escherichia Escherichia NNP cord-271526-14nfqusv 63 28 coli coli NNS cord-271526-14nfqusv 63 29 bacteriophages bacteriophage NNS cord-271526-14nfqusv 63 30 . . . cord-271526-14nfqusv 64 1 ( ( -LRB- cord-271526-14nfqusv 64 2 Owen Owen NNP cord-271526-14nfqusv 64 3 and and CC cord-271526-14nfqusv 64 4 Kuhn Kuhn NNP cord-271526-14nfqusv 64 5 , , , cord-271526-14nfqusv 64 6 1996 1996 CD cord-271526-14nfqusv 64 7 ; ; : cord-271526-14nfqusv 64 8 _SP cord-271526-14nfqusv 64 9 from from IN cord-271526-14nfqusv 64 10 a a DT cord-271526-14nfqusv 64 11 Ser Ser NNP cord-271526-14nfqusv 64 12 to to IN cord-271526-14nfqusv 64 13 an an DT cord-271526-14nfqusv 64 14 Ala. Alabama NNP cord-271526-14nfqusv 65 1 The the DT cord-271526-14nfqusv 65 2 reconstituted reconstitute VBN cord-271526-14nfqusv 65 3 N n CD cord-271526-14nfqusv 65 4 gene gene NN cord-271526-14nfqusv 65 5 was be VBD cord-271526-14nfqusv 65 6 Berkowitz Berkowitz NNP cord-271526-14nfqusv 65 7 et et NNP cord-271526-14nfqusv 65 8 al al NNP cord-271526-14nfqusv 65 9 . . NNP cord-271526-14nfqusv 65 10 , , , cord-271526-14nfqusv 65 11 1995 1995 CD cord-271526-14nfqusv 65 12 ; ; : cord-271526-14nfqusv 65 13 Zhang Zhang NNP cord-271526-14nfqusv 65 14 and and CC cord-271526-14nfqusv 65 15 Barklis Barklis NNP cord-271526-14nfqusv 65 16 , , , cord-271526-14nfqusv 65 17 1995 1995 CD cord-271526-14nfqusv 65 18 ; ; : cord-271526-14nfqusv 65 19 Schle- Schle- NNP cord-271526-14nfqusv 65 20 then then RB cord-271526-14nfqusv 65 21 exchanged exchange VBD cord-271526-14nfqusv 65 22 with with IN cord-271526-14nfqusv 65 23 the the DT cord-271526-14nfqusv 65 24 NcoI NcoI NNP cord-271526-14nfqusv 65 25 - - HYPH cord-271526-14nfqusv 65 26 BamHI BamHI NNP cord-271526-14nfqusv 65 27 fragment fragment NN cord-271526-14nfqusv 65 28 of of IN cord-271526-14nfqusv 65 29 pL1a pl1a CD cord-271526-14nfqusv 65 30 singer singer NN cord-271526-14nfqusv 65 31 et et NNP cord-271526-14nfqusv 65 32 Dupraz Dupraz NNP cord-271526-14nfqusv 65 33 and and CC cord-271526-14nfqusv 65 34 Spahr Spahr NNP cord-271526-14nfqusv 65 35 , , , cord-271526-14nfqusv 65 36 1992 1992 CD cord-271526-14nfqusv 65 37 ; ; : cord-271526-14nfqusv 65 38 Witherell Witherell NNP cord-271526-14nfqusv 65 39 et et NNP cord-271526-14nfqusv 65 40 ( ( -LRB- cord-271526-14nfqusv 65 41 Snijder Snijder NNP cord-271526-14nfqusv 65 42 et et NNP cord-271526-14nfqusv 65 43 al al NNP cord-271526-14nfqusv 65 44 . . NNP cord-271526-14nfqusv 65 45 , , , cord-271526-14nfqusv 65 46 1996 1996 CD cord-271526-14nfqusv 65 47 ) ) -RRB- cord-271526-14nfqusv 65 48 and and CC cord-271526-14nfqusv 65 49 the the DT cord-271526-14nfqusv 65 50 sequence sequence NN cord-271526-14nfqusv 65 51 of of IN cord-271526-14nfqusv 65 52 the the DT cord-271526-14nfqusv 65 53 NcoI NcoI NNP cord-271526-14nfqusv 65 54 - - HYPH cord-271526-14nfqusv 65 55 ApaI ApaI NNP cord-271526-14nfqusv 65 56 al al NNP cord-271526-14nfqusv 65 57 . . NNP cord-271526-14nfqusv 65 58 , , , cord-271526-14nfqusv 65 59 1991 1991 CD cord-271526-14nfqusv 65 60 ; ; : cord-271526-14nfqusv 65 61 Aldovini Aldovini NNP cord-271526-14nfqusv 65 62 and and CC cord-271526-14nfqusv 65 63 Young Young NNP cord-271526-14nfqusv 65 64 , , , cord-271526-14nfqusv 65 65 1990 1990 CD cord-271526-14nfqusv 65 66 ; ; : cord-271526-14nfqusv 65 67 Weis Weis NNP cord-271526-14nfqusv 65 68 et et NNP cord-271526-14nfqusv 65 69 al al NNP cord-271526-14nfqusv 65 70 . . NNP cord-271526-14nfqusv 65 71 , , , cord-271526-14nfqusv 65 72 1989 1989 CD cord-271526-14nfqusv 65 73 ) ) -RRB- cord-271526-14nfqusv 65 74 . . . cord-271526-14nfqusv 66 1 fragment fragment NN cord-271526-14nfqusv 66 2 was be VBD cord-271526-14nfqusv 66 3 confirmed confirm VBN cord-271526-14nfqusv 66 4 by by IN cord-271526-14nfqusv 66 5 sequence sequence NN cord-271526-14nfqusv 66 6 analysis analysis NN cord-271526-14nfqusv 66 7 . . . cord-271526-14nfqusv 67 1 The the DT cord-271526-14nfqusv 67 2 final final NN cord-271526-14nfqusv 67 3 However however RB cord-271526-14nfqusv 67 4 , , , cord-271526-14nfqusv 67 5 a a DT cord-271526-14nfqusv 67 6 specific specific JJ cord-271526-14nfqusv 67 7 interaction interaction NN cord-271526-14nfqusv 67 8 of of IN cord-271526-14nfqusv 67 9 the the DT cord-271526-14nfqusv 67 10 MHV MHV NNP cord-271526-14nfqusv 67 11 N N NNP cord-271526-14nfqusv 67 12 protein protein NN cord-271526-14nfqusv 67 13 expression expression NN cord-271526-14nfqusv 67 14 vector vector NN cord-271526-14nfqusv 67 15 , , , cord-271526-14nfqusv 67 16 pEMCV pEMCV NNP cord-271526-14nfqusv 67 17 - - HYPH cord-271526-14nfqusv 67 18 N N NNP cord-271526-14nfqusv 67 19 , , , cord-271526-14nfqusv 67 20 contained contain VBD cord-271526-14nfqusv 67 21 a a DT cord-271526-14nfqusv 67 22 T7 T7 NNP cord-271526-14nfqusv 67 23 promoter promoter NN cord-271526-14nfqusv 67 24 with with IN cord-271526-14nfqusv 67 25 the the DT cord-271526-14nfqusv 67 26 Ps Ps NNP cord-271526-14nfqusv 67 27 has have VBZ cord-271526-14nfqusv 67 28 not not RB cord-271526-14nfqusv 67 29 been be VBN cord-271526-14nfqusv 67 30 demonstrated demonstrate VBN cord-271526-14nfqusv 67 31 yet yet RB cord-271526-14nfqusv 67 32 . . . cord-271526-14nfqusv 68 1 and and CC cord-271526-14nfqusv 68 2 EMCV EMCV NNP cord-271526-14nfqusv 68 3 - - HYPH cord-271526-14nfqusv 68 4 NTR NTR NNP cord-271526-14nfqusv 68 5 , , , cord-271526-14nfqusv 68 6 followed follow VBN cord-271526-14nfqusv 68 7 by by IN cord-271526-14nfqusv 68 8 the the DT cord-271526-14nfqusv 68 9 entire entire JJ cord-271526-14nfqusv 68 10 N n CD cord-271526-14nfqusv 68 11 gene gene NN cord-271526-14nfqusv 68 12 and and CC cord-271526-14nfqusv 68 13 a a DT cord-271526-14nfqusv 68 14 T7 t7 NN cord-271526-14nfqusv 68 15 In in IN cord-271526-14nfqusv 68 16 this this DT cord-271526-14nfqusv 68 17 report report NN cord-271526-14nfqusv 69 1 we -PRON- PRP cord-271526-14nfqusv 69 2 have have VBP cord-271526-14nfqusv 69 3 used use VBN cord-271526-14nfqusv 69 4 gel gel NN cord-271526-14nfqusv 69 5 retardation retardation NN cord-271526-14nfqusv 69 6 and and CC cord-271526-14nfqusv 69 7 UV uv NN cord-271526-14nfqusv 69 8 terminator terminator NN cord-271526-14nfqusv 69 9 sequence sequence NN cord-271526-14nfqusv 69 10 . . . cord-271526-14nfqusv 70 1 cross cross JJ cord-271526-14nfqusv 70 2 - - JJ cord-271526-14nfqusv 70 3 linking link VBG cord-271526-14nfqusv 70 4 assays assay NNS cord-271526-14nfqusv 70 5 to to TO cord-271526-14nfqusv 70 6 study study VB cord-271526-14nfqusv 70 7 the the DT cord-271526-14nfqusv 70 8 in in FW cord-271526-14nfqusv 70 9 vitro vitro FW cord-271526-14nfqusv 70 10 interaction interaction NN cord-271526-14nfqusv 70 11 of of IN cord-271526-14nfqusv 70 12 MHV MHV NNP cord-271526-14nfqusv 70 13 - - HYPH cord-271526-14nfqusv 70 14 A59 A59 NNP cord-271526-14nfqusv 70 15 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 70 16 protein protein NN cord-271526-14nfqusv 70 17 and and CC cord-271526-14nfqusv 70 18 a a DT cord-271526-14nfqusv 70 19 small small JJ cord-271526-14nfqusv 70 20 RNA RNA NNP cord-271526-14nfqusv 70 21 con con NN cord-271526-14nfqusv 70 22 - - HYPH cord-271526-14nfqusv 70 23 Preparation Preparation NNP cord-271526-14nfqusv 70 24 of of IN cord-271526-14nfqusv 70 25 riboprobe riboprobe NNP cord-271526-14nfqusv 70 26 taining taine VBG cord-271526-14nfqusv 70 27 the the DT cord-271526-14nfqusv 70 28 Ps Ps NNP cord-271526-14nfqusv 70 29 domain domain NN cord-271526-14nfqusv 70 30 . . . cord-271526-14nfqusv 71 1 We -PRON- PRP cord-271526-14nfqusv 71 2 observed observe VBD cord-271526-14nfqusv 71 3 specific specific JJ cord-271526-14nfqusv 71 4 interaction interaction NN cord-271526-14nfqusv 72 1 In in IN cord-271526-14nfqusv 72 2 order order NN cord-271526-14nfqusv 72 3 to to TO cord-271526-14nfqusv 72 4 serve serve VB cord-271526-14nfqusv 72 5 as as IN cord-271526-14nfqusv 72 6 template template NN cord-271526-14nfqusv 72 7 DNA dna NN cord-271526-14nfqusv 72 8 , , , cord-271526-14nfqusv 72 9 pPs290 pPs290 NNP cord-271526-14nfqusv 72 10 was be VBD cord-271526-14nfqusv 72 11 linearbetween linearbetween VBN cord-271526-14nfqusv 72 12 in in IN cord-271526-14nfqusv 72 13 vitro vitro FW cord-271526-14nfqusv 72 14 transcripts transcript NNS cord-271526-14nfqusv 72 15 containing contain VBG cord-271526-14nfqusv 72 16 the the DT cord-271526-14nfqusv 72 17 Ps Ps NNP cord-271526-14nfqusv 72 18 and and CC cord-271526-14nfqusv 72 19 N n CD cord-271526-14nfqusv 72 20 proized proize VBD cord-271526-14nfqusv 72 21 with with IN cord-271526-14nfqusv 72 22 BamHI BamHI NNP cord-271526-14nfqusv 72 23 , , , cord-271526-14nfqusv 72 24 extracted extract VBN cord-271526-14nfqusv 72 25 with with IN cord-271526-14nfqusv 72 26 phenol phenol NN cord-271526-14nfqusv 72 27 / / SYM cord-271526-14nfqusv 72 28 chloroform chloroform NN cord-271526-14nfqusv 72 29 , , , cord-271526-14nfqusv 72 30 and and CC cord-271526-14nfqusv 73 1 tein tein NNP cord-271526-14nfqusv 73 2 isolated isolate VBN cord-271526-14nfqusv 73 3 from from IN cord-271526-14nfqusv 73 4 infected infected JJ cord-271526-14nfqusv 73 5 cells cell NNS cord-271526-14nfqusv 73 6 , , , cord-271526-14nfqusv 73 7 but but CC cord-271526-14nfqusv 73 8 also also RB cord-271526-14nfqusv 73 9 with with IN cord-271526-14nfqusv 73 10 N n CD cord-271526-14nfqusv 73 11 protein protein NN cord-271526-14nfqusv 73 12 precipitated precipitate VBN cord-271526-14nfqusv 73 13 with with IN cord-271526-14nfqusv 73 14 ethanol ethanol NN cord-271526-14nfqusv 73 15 . . . cord-271526-14nfqusv 74 1 Alternatively alternatively RB cord-271526-14nfqusv 74 2 , , , cord-271526-14nfqusv 74 3 templates template NNS cord-271526-14nfqusv 74 4 for for IN cord-271526-14nfqusv 74 5 the the DT cord-271526-14nfqusv 74 6 extracted extract VBN cord-271526-14nfqusv 74 7 from from IN cord-271526-14nfqusv 74 8 purified purify VBN cord-271526-14nfqusv 74 9 viruses virus NNS cord-271526-14nfqusv 74 10 . . . cord-271526-14nfqusv 75 1 Furthermore furthermore RB cord-271526-14nfqusv 75 2 , , , cord-271526-14nfqusv 75 3 we -PRON- PRP cord-271526-14nfqusv 75 4 were be VBD cord-271526-14nfqusv 75 5 production production NN cord-271526-14nfqusv 75 6 of of IN cord-271526-14nfqusv 75 7 Ps180 ps180 NN cord-271526-14nfqusv 75 8 and and CC cord-271526-14nfqusv 76 1 PsDHP PsDHP NNP cord-271526-14nfqusv 76 2 RNA RNA NNP cord-271526-14nfqusv 76 3 were be VBD cord-271526-14nfqusv 76 4 produced produce VBN cord-271526-14nfqusv 76 5 by by IN cord-271526-14nfqusv 76 6 able able JJ cord-271526-14nfqusv 76 7 to to TO cord-271526-14nfqusv 76 8 identify identify VB cord-271526-14nfqusv 76 9 a a DT cord-271526-14nfqusv 76 10 similar similar JJ cord-271526-14nfqusv 76 11 interaction interaction NN cord-271526-14nfqusv 76 12 with with IN cord-271526-14nfqusv 76 13 recombinant recombinant JJ cord-271526-14nfqusv 76 14 PCR PCR NNP cord-271526-14nfqusv 76 15 using use VBG cord-271526-14nfqusv 76 16 a a DT cord-271526-14nfqusv 76 17 5 5 CD cord-271526-14nfqusv 76 18 oligonucleotide oligonucleotide NN cord-271526-14nfqusv 76 19 containing contain VBG cord-271526-14nfqusv 76 20 the the DT cord-271526-14nfqusv 76 21 T7 T7 NNP cord-271526-14nfqusv 76 22 pronucleocapsid pronucleocapsid NN cord-271526-14nfqusv 76 23 protein protein NN cord-271526-14nfqusv 76 24 expressed express VBN cord-271526-14nfqusv 76 25 in in IN cord-271526-14nfqusv 76 26 the the DT cord-271526-14nfqusv 76 27 vaccinia vaccinia NN cord-271526-14nfqusv 76 28 T7 t7 NN cord-271526-14nfqusv 76 29 exmoter exmoter NN cord-271526-14nfqusv 76 30 sequence sequence NN cord-271526-14nfqusv 76 31 in in IN cord-271526-14nfqusv 76 32 addition addition NN cord-271526-14nfqusv 76 33 to to IN cord-271526-14nfqusv 76 34 MHV MHV NNP cord-271526-14nfqusv 76 35 specific specific JJ cord-271526-14nfqusv 76 36 sequences sequence NNS cord-271526-14nfqusv 76 37 pression pression NN cord-271526-14nfqusv 76 38 system system NN cord-271526-14nfqusv 76 39 . . . cord-271526-14nfqusv 77 1 These these DT cord-271526-14nfqusv 77 2 experiments experiment NNS cord-271526-14nfqusv 77 3 underline underline VBP cord-271526-14nfqusv 77 4 the the DT cord-271526-14nfqusv 77 5 possi- possi- NN cord-271526-14nfqusv 78 1 ( ( -LRB- cord-271526-14nfqusv 78 2 Table table NN cord-271526-14nfqusv 78 3 1 1 CD cord-271526-14nfqusv 78 4 ) ) -RRB- cord-271526-14nfqusv 78 5 . . . cord-271526-14nfqusv 79 1 Radiolabeled Radiolabeled NNP cord-271526-14nfqusv 79 2 RNA RNA NNP cord-271526-14nfqusv 79 3 was be VBD cord-271526-14nfqusv 79 4 synthesized synthesize VBN cord-271526-14nfqusv 79 5 by by IN cord-271526-14nfqusv 79 6 T7 T7 NNP cord-271526-14nfqusv 79 7 tranbility tranbility NN cord-271526-14nfqusv 79 8 of of IN cord-271526-14nfqusv 79 9 studying study VBG cord-271526-14nfqusv 79 10 the the DT cord-271526-14nfqusv 79 11 encapsidation encapsidation NN cord-271526-14nfqusv 79 12 of of IN cord-271526-14nfqusv 79 13 MHV MHV NNP cord-271526-14nfqusv 79 14 - - HYPH cord-271526-14nfqusv 79 15 A59 A59 NNP cord-271526-14nfqusv 79 16 RNA RNA NNP cord-271526-14nfqusv 79 17 at at IN cord-271526-14nfqusv 79 18 scription scription NN cord-271526-14nfqusv 79 19 for for IN cord-271526-14nfqusv 79 20 1.5 1.5 CD cord-271526-14nfqusv 79 21 h h NN cord-271526-14nfqusv 79 22 at at IN cord-271526-14nfqusv 79 23 37Њ. 37њ. CD cord-271526-14nfqusv 79 24 Reactions reaction NNS cord-271526-14nfqusv 79 25 contained contain VBD cord-271526-14nfqusv 79 26 1 1 CD cord-271526-14nfqusv 79 27 mg mg NN cord-271526-14nfqusv 79 28 of of IN cord-271526-14nfqusv 79 29 a a DT cord-271526-14nfqusv 79 30 molecular molecular JJ cord-271526-14nfqusv 79 31 basis basis NN cord-271526-14nfqusv 79 32 and and CC cord-271526-14nfqusv 79 33 allow allow VB cord-271526-14nfqusv 79 34 us -PRON- PRP cord-271526-14nfqusv 79 35 to to TO cord-271526-14nfqusv 79 36 map map VB cord-271526-14nfqusv 79 37 important important JJ cord-271526-14nfqusv 79 38 dolinearized dolinearize VBN cord-271526-14nfqusv 79 39 plasmid plasmid NN cord-271526-14nfqusv 79 40 DNA DNA NNP cord-271526-14nfqusv 79 41 , , , cord-271526-14nfqusv 79 42 1 1 CD cord-271526-14nfqusv 79 43 mM mm CD cord-271526-14nfqusv 79 44 ( ( -LRB- cord-271526-14nfqusv 79 45 each each DT cord-271526-14nfqusv 79 46 ) ) -RRB- cord-271526-14nfqusv 79 47 ATP ATP NNP cord-271526-14nfqusv 79 48 , , , cord-271526-14nfqusv 79 49 CTP CTP NNP cord-271526-14nfqusv 79 50 , , , cord-271526-14nfqusv 79 51 and and CC cord-271526-14nfqusv 79 52 mains main NNS cord-271526-14nfqusv 79 53 in in IN cord-271526-14nfqusv 79 54 both both CC cord-271526-14nfqusv 79 55 the the DT cord-271526-14nfqusv 79 56 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 79 57 protein protein NN cord-271526-14nfqusv 79 58 as as RB cord-271526-14nfqusv 79 59 well well RB cord-271526-14nfqusv 79 60 as as IN cord-271526-14nfqusv 79 61 the the DT cord-271526-14nfqusv 79 62 GTP GTP NNP cord-271526-14nfqusv 79 63 , , , cord-271526-14nfqusv 79 64 50 50 CD cord-271526-14nfqusv 79 65 mM mm CD cord-271526-14nfqusv 79 66 UTP UTP NNP cord-271526-14nfqusv 79 67 , , , cord-271526-14nfqusv 79 68 10 10 CD cord-271526-14nfqusv 79 69 mCi mCi NNS cord-271526-14nfqusv 79 70 of of IN cord-271526-14nfqusv 79 71 [ [ -LRB- cord-271526-14nfqusv 79 72 a-32 a-32 NNP cord-271526-14nfqusv 79 73 P]UTP P]UTP NNP cord-271526-14nfqusv 79 74 ( ( -LRB- cord-271526-14nfqusv 79 75 3000 3000 CD cord-271526-14nfqusv 79 76 Ci ci NN cord-271526-14nfqusv 79 77 / / SYM cord-271526-14nfqusv 79 78 mmol mmol NN cord-271526-14nfqusv 79 79 ) ) -RRB- cord-271526-14nfqusv 79 80 , , , cord-271526-14nfqusv 79 81 RNA RNA NNP cord-271526-14nfqusv 79 82 packaging packaging NN cord-271526-14nfqusv 79 83 signal signal NN cord-271526-14nfqusv 79 84 . . . cord-271526-14nfqusv 80 1 and and CC cord-271526-14nfqusv 80 2 25 25 CD cord-271526-14nfqusv 80 3 units unit NNS cord-271526-14nfqusv 80 4 of of IN cord-271526-14nfqusv 80 5 T7 t7 NN cord-271526-14nfqusv 80 6 polymerase polymerase NN cord-271526-14nfqusv 80 7 in in IN cord-271526-14nfqusv 80 8 a a DT cord-271526-14nfqusv 80 9 final final JJ cord-271526-14nfqusv 80 10 volume volume NN cord-271526-14nfqusv 80 11 of of IN cord-271526-14nfqusv 80 12 25 25 CD cord-271526-14nfqusv 80 13 ml ml NN cord-271526-14nfqusv 80 14 transcription transcription NN cord-271526-14nfqusv 80 15 buffer buffer NN cord-271526-14nfqusv 80 16 ( ( -LRB- cord-271526-14nfqusv 80 17 Gibco Gibco NNP cord-271526-14nfqusv 80 18 BRL BRL NNP cord-271526-14nfqusv 80 19 ) ) -RRB- cord-271526-14nfqusv 80 20 . . . cord-271526-14nfqusv 81 1 The the DT cord-271526-14nfqusv 81 2 reaction reaction NN cord-271526-14nfqusv 81 3 products product NNS cord-271526-14nfqusv 81 4 MATERIALS material NNS cord-271526-14nfqusv 81 5 AND and CC cord-271526-14nfqusv 81 6 METHODS method NNS cord-271526-14nfqusv 81 7 were be VBD cord-271526-14nfqusv 81 8 extracted extract VBN cord-271526-14nfqusv 81 9 with with IN cord-271526-14nfqusv 81 10 phenol phenol NN cord-271526-14nfqusv 81 11 / / SYM cord-271526-14nfqusv 81 12 chloroform chloroform NN cord-271526-14nfqusv 81 13 , , , cord-271526-14nfqusv 81 14 purified purify VBN cord-271526-14nfqusv 81 15 on on IN cord-271526-14nfqusv 81 16 a a DT cord-271526-14nfqusv 81 17 Sephadex Sephadex NNP cord-271526-14nfqusv 81 18 G50 G50 NNP cord-271526-14nfqusv 81 19 collumn collumn NN cord-271526-14nfqusv 81 20 and and CC cord-271526-14nfqusv 81 21 precipitated precipitate VBN cord-271526-14nfqusv 81 22 by by IN cord-271526-14nfqusv 81 23 adding add VBG cord-271526-14nfqusv 81 24 1/10 1/10 CD cord-271526-14nfqusv 81 25 Cells cell NNS cord-271526-14nfqusv 81 26 and and CC cord-271526-14nfqusv 81 27 viruses virus NNS cord-271526-14nfqusv 81 28 volume volume NN cord-271526-14nfqusv 81 29 of of IN cord-271526-14nfqusv 81 30 5 5 CD cord-271526-14nfqusv 81 31 M M NNP cord-271526-14nfqusv 81 32 NH NH NNP cord-271526-14nfqusv 81 33 4 4 CD cord-271526-14nfqusv 81 34 Ac Ac NNP cord-271526-14nfqusv 81 35 ( ( -LRB- cord-271526-14nfqusv 81 36 pH pH NNP cord-271526-14nfqusv 81 37 5.2 5.2 CD cord-271526-14nfqusv 81 38 ) ) -RRB- cord-271526-14nfqusv 81 39 and and CC cord-271526-14nfqusv 81 40 2 2 CD cord-271526-14nfqusv 81 41 vol vol NN cord-271526-14nfqusv 81 42 of of IN cord-271526-14nfqusv 81 43 ethanol ethanol NN cord-271526-14nfqusv 81 44 . . . cord-271526-14nfqusv 82 1 The the DT cord-271526-14nfqusv 82 2 Mouse Mouse NNP cord-271526-14nfqusv 82 3 L L NNP cord-271526-14nfqusv 82 4 cells cell NNS cord-271526-14nfqusv 82 5 were be VBD cord-271526-14nfqusv 82 6 grown grow VBN cord-271526-14nfqusv 82 7 in in IN cord-271526-14nfqusv 82 8 Dulbecco Dulbecco NNP cord-271526-14nfqusv 82 9 's 's POS cord-271526-14nfqusv 82 10 modified modify VBN cord-271526-14nfqusv 82 11 Eaamount Eaamount NNP cord-271526-14nfqusv 82 12 of of IN cord-271526-14nfqusv 82 13 incorporated incorporated JJ cord-271526-14nfqusv 82 14 label label NN cord-271526-14nfqusv 82 15 was be VBD cord-271526-14nfqusv 82 16 determined determine VBN cord-271526-14nfqusv 82 17 by by IN cord-271526-14nfqusv 82 18 TCA TCA NNP cord-271526-14nfqusv 82 19 gle gle NNP cord-271526-14nfqusv 82 20 's 's POS cord-271526-14nfqusv 82 21 medium medium NN cord-271526-14nfqusv 82 22 ( ( -LRB- cord-271526-14nfqusv 82 23 DMEM DMEM NNP cord-271526-14nfqusv 82 24 ; ; : cord-271526-14nfqusv 82 25 Gibco Gibco NNP cord-271526-14nfqusv 82 26 ) ) -RRB- cord-271526-14nfqusv 82 27 supplemented supplement VBD cord-271526-14nfqusv 82 28 with with IN cord-271526-14nfqusv 82 29 8 8 CD cord-271526-14nfqusv 82 30 % % NN cord-271526-14nfqusv 82 31 fetal fetal JJ cord-271526-14nfqusv 82 32 precipitation precipitation NN cord-271526-14nfqusv 82 33 . . . cord-271526-14nfqusv 83 1 calf calf NN cord-271526-14nfqusv 83 2 serum serum NN cord-271526-14nfqusv 83 3 . . . cord-271526-14nfqusv 84 1 MHV MHV NNP cord-271526-14nfqusv 84 2 - - HYPH cord-271526-14nfqusv 84 3 A59 A59 NNP cord-271526-14nfqusv 84 4 stocks stock NNS cord-271526-14nfqusv 84 5 were be VBD cord-271526-14nfqusv 84 6 grown grow VBN cord-271526-14nfqusv 84 7 as as IN cord-271526-14nfqusv 84 8 described describe VBN cord-271526-14nfqusv 84 9 ( ( -LRB- cord-271526-14nfqusv 84 10 Spaan Spaan NNP cord-271526-14nfqusv 84 11 et et FW cord-271526-14nfqusv 84 12 al al NNP cord-271526-14nfqusv 84 13 . . NNP cord-271526-14nfqusv 84 14 , , , cord-271526-14nfqusv 84 15 1981 1981 CD cord-271526-14nfqusv 84 16 ) ) -RRB- cord-271526-14nfqusv 85 1 phenylmethylsulfonyl phenylmethylsulfonyl NNP cord-271526-14nfqusv 85 2 fluoride fluoride NNP cord-271526-14nfqusv 85 3 , , , cord-271526-14nfqusv 85 4 0.5 0.5 CD cord-271526-14nfqusv 85 5 mM mm CD cord-271526-14nfqusv 85 6 dithiothreitol dithiothreitol NN cord-271526-14nfqusv 85 7 10 10 CD cord-271526-14nfqusv 85 8 ml ml NN cord-271526-14nfqusv 85 9 binding bind VBG cord-271526-14nfqusv 85 10 buffer buffer NN cord-271526-14nfqusv 85 11 ( ( -LRB- cord-271526-14nfqusv 85 12 5 5 CD cord-271526-14nfqusv 85 13 mM mm CD cord-271526-14nfqusv 85 14 HEPES HEPES NNP cord-271526-14nfqusv 85 15 ( ( -LRB- cord-271526-14nfqusv 85 16 pH pH NNP cord-271526-14nfqusv 85 17 7.9 7.9 CD cord-271526-14nfqusv 85 18 ) ) -RRB- cord-271526-14nfqusv 85 19 , , , cord-271526-14nfqusv 85 20 50 50 CD cord-271526-14nfqusv 85 21 mM mm CD cord-271526-14nfqusv 85 22 KAc KAc NNS cord-271526-14nfqusv 85 23 , , , cord-271526-14nfqusv 85 24 2.4 2.4 CD cord-271526-14nfqusv 85 25 mM mm CD cord-271526-14nfqusv 85 26 MgAc MgAc NNP cord-271526-14nfqusv 85 27 2 2 CD cord-271526-14nfqusv 85 28 , , , cord-271526-14nfqusv 85 29 0.1 0.1 CD cord-271526-14nfqusv 85 30 mM mm CD cord-271526-14nfqusv 85 31 EDTA EDTA NNP cord-271526-14nfqusv 85 32 , , , cord-271526-14nfqusv 85 33 0.01 0.01 CD cord-271526-14nfqusv 85 34 mM mm CD cord-271526-14nfqusv 85 35 DTT DTT NNP cord-271526-14nfqusv 85 36 , , , cord-271526-14nfqusv 85 37 1 1 CD cord-271526-14nfqusv 85 38 mM mm CD cord-271526-14nfqusv 85 39 ATP ATP NNP cord-271526-14nfqusv 85 40 , , , cord-271526-14nfqusv 85 41 ( ( -LRB- cord-271526-14nfqusv 85 42 DTT DTT NNP cord-271526-14nfqusv 85 43 ) ) -RRB- cord-271526-14nfqusv 85 44 ) ) -RRB- cord-271526-14nfqusv 86 1 ( ( -LRB- cord-271526-14nfqusv 86 2 Dignam Dignam NNP cord-271526-14nfqusv 86 3 et et FW cord-271526-14nfqusv 86 4 al al NNP cord-271526-14nfqusv 86 5 . . NNP cord-271526-14nfqusv 86 6 , , , cord-271526-14nfqusv 86 7 1983 1983 CD cord-271526-14nfqusv 86 8 ) ) -RRB- cord-271526-14nfqusv 86 9 . . . cord-271526-14nfqusv 87 1 Subsequently subsequently RB cord-271526-14nfqusv 87 2 , , , cord-271526-14nfqusv 87 3 the the DT cord-271526-14nfqusv 87 4 cells cell NNS cord-271526-14nfqusv 87 5 were be VBD cord-271526-14nfqusv 87 6 disrupted disrupt VBN cord-271526-14nfqusv 87 7 by by IN cord-271526-14nfqusv 87 8 freezing freeze VBG cord-271526-14nfqusv 87 9 ( ( -LRB- cord-271526-14nfqusv 87 10 080Њ 080њ CD cord-271526-14nfqusv 87 11 ) ) -RRB- cord-271526-14nfqusv 87 12 and and CC cord-271526-14nfqusv 87 13 thawing thaw VBG cord-271526-14nfqusv 87 14 ( ( -LRB- cord-271526-14nfqusv 87 15 37Њ 37Њ NNP cord-271526-14nfqusv 87 16 ) ) -RRB- cord-271526-14nfqusv 87 17 once once RB cord-271526-14nfqusv 87 18 or or CC cord-271526-14nfqusv 87 19 0.4 0.4 CD cord-271526-14nfqusv 87 20 mM mm CD cord-271526-14nfqusv 87 21 GTP GTP NNP cord-271526-14nfqusv 87 22 ) ) -RRB- cord-271526-14nfqusv 87 23 . . . cord-271526-14nfqusv 88 1 Where where WRB cord-271526-14nfqusv 88 2 necessary necessary JJ cord-271526-14nfqusv 88 3 specific specific JJ cord-271526-14nfqusv 88 4 or or CC cord-271526-14nfqusv 88 5 nonspecific nonspecific JJ cord-271526-14nfqusv 88 6 competitor competitor NN cord-271526-14nfqusv 88 7 RNA RNA NNP cord-271526-14nfqusv 88 8 was be VBD cord-271526-14nfqusv 88 9 added add VBN cord-271526-14nfqusv 88 10 as as IN cord-271526-14nfqusv 88 11 indicated indicate VBN cord-271526-14nfqusv 88 12 in in IN cord-271526-14nfqusv 88 13 the the DT cord-271526-14nfqusv 88 14 figure figure NN cord-271526-14nfqusv 88 15 by by IN cord-271526-14nfqusv 88 16 15 15 CD cord-271526-14nfqusv 88 17 strokes stroke NNS cord-271526-14nfqusv 88 18 of of IN cord-271526-14nfqusv 88 19 a a DT cord-271526-14nfqusv 88 20 Dounce Dounce NNP cord-271526-14nfqusv 88 21 homogenizer homogenizer NN cord-271526-14nfqusv 88 22 . . . cord-271526-14nfqusv 89 1 Cellular cellular JJ cord-271526-14nfqusv 89 2 debris debris NN cord-271526-14nfqusv 89 3 and and CC cord-271526-14nfqusv 89 4 nuclei nucleus NNS cord-271526-14nfqusv 89 5 were be VBD cord-271526-14nfqusv 89 6 removed remove VBN cord-271526-14nfqusv 89 7 by by IN cord-271526-14nfqusv 89 8 centrifugation centrifugation NN cord-271526-14nfqusv 89 9 for for IN cord-271526-14nfqusv 89 10 30 30 CD cord-271526-14nfqusv 89 11 min min NN cord-271526-14nfqusv 89 12 at at IN cord-271526-14nfqusv 89 13 legends legend NNS cord-271526-14nfqusv 89 14 . . . cord-271526-14nfqusv 90 1 In in IN cord-271526-14nfqusv 90 2 supershift supershift NN cord-271526-14nfqusv 90 3 experiments experiment NNS cord-271526-14nfqusv 90 4 , , , cord-271526-14nfqusv 90 5 1 1 CD cord-271526-14nfqusv 90 6 ml ml NNS cord-271526-14nfqusv 90 7 of of IN cord-271526-14nfqusv 90 8 the the DT cord-271526-14nfqusv 90 9 N n CD cord-271526-14nfqusv 90 10 - - HYPH cord-271526-14nfqusv 90 11 specific specific JJ cord-271526-14nfqusv 90 12 monoclonal monoclonal JJ cord-271526-14nfqusv 90 13 antibody antibody NN cord-271526-14nfqusv 90 14 5B188.2 5b188.2 CD cord-271526-14nfqusv 91 1 ( ( -LRB- cord-271526-14nfqusv 91 2 Talbot Talbot NNP cord-271526-14nfqusv 91 3 and and CC cord-271526-14nfqusv 91 4 Buchmeier Buchmeier NNP cord-271526-14nfqusv 91 5 , , , cord-271526-14nfqusv 91 6 13,000 13,000 CD cord-271526-14nfqusv 91 7 rpm rpm NN cord-271526-14nfqusv 91 8 at at IN cord-271526-14nfqusv 91 9 4Њ. 4њ. CD cord-271526-14nfqusv 92 1 The the DT cord-271526-14nfqusv 92 2 supernatant supernatant NN cord-271526-14nfqusv 92 3 was be VBD cord-271526-14nfqusv 92 4 aliquoted aliquote VBN cord-271526-14nfqusv 92 5 and and CC cord-271526-14nfqusv 92 6 stored store VBN cord-271526-14nfqusv 92 7 at at IN cord-271526-14nfqusv 92 8 080Њ. 080Њ. NNP cord-271526-14nfqusv 93 1 The the DT cord-271526-14nfqusv 93 2 protein protein NN cord-271526-14nfqusv 93 3 concentration concentration NN cord-271526-14nfqusv 93 4 was be VBD cord-271526-14nfqusv 93 5 deter-1985 deter-1985 NNP cord-271526-14nfqusv 93 6 ) ) -RRB- cord-271526-14nfqusv 93 7 or or CC cord-271526-14nfqusv 93 8 b b NN cord-271526-14nfqusv 93 9 - - HYPH cord-271526-14nfqusv 93 10 galactosidase galactosidase NN cord-271526-14nfqusv 93 11 monoclonal monoclonal JJ cord-271526-14nfqusv 93 12 antibody antibody NN cord-271526-14nfqusv 93 13 ( ( -LRB- cord-271526-14nfqusv 93 14 Boehringer Boehringer NNP cord-271526-14nfqusv 93 15 Mannheim Mannheim NNP cord-271526-14nfqusv 93 16 ) ) -RRB- cord-271526-14nfqusv 93 17 and and CC cord-271526-14nfqusv 93 18 18 18 CD cord-271526-14nfqusv 93 19 units unit NNS cord-271526-14nfqusv 93 20 of of IN cord-271526-14nfqusv 93 21 RNAGuard RNAGuard NNP cord-271526-14nfqusv 93 22 ( ( -LRB- cord-271526-14nfqusv 93 23 Pharmacia Pharmacia NNP cord-271526-14nfqusv 93 24 ) ) -RRB- cord-271526-14nfqusv 93 25 mined mine VBD cord-271526-14nfqusv 93 26 using use VBG cord-271526-14nfqusv 93 27 the the DT cord-271526-14nfqusv 93 28 Bicinchoninic Bicinchoninic NNP cord-271526-14nfqusv 93 29 Acid Acid NNP cord-271526-14nfqusv 93 30 Protein Protein NNP cord-271526-14nfqusv 93 31 Assay Assay NNP cord-271526-14nfqusv 93 32 Kit kit NN cord-271526-14nfqusv 93 33 ( ( -LRB- cord-271526-14nfqusv 93 34 Sigma Sigma NNP cord-271526-14nfqusv 93 35 ) ) -RRB- cord-271526-14nfqusv 93 36 . . . cord-271526-14nfqusv 94 1 were be VBD cord-271526-14nfqusv 94 2 added add VBN cord-271526-14nfqusv 94 3 . . . cord-271526-14nfqusv 95 1 The the DT cord-271526-14nfqusv 95 2 mixtures mixture NNS cord-271526-14nfqusv 95 3 were be VBD cord-271526-14nfqusv 95 4 incubated incubate VBN cord-271526-14nfqusv 95 5 at at IN cord-271526-14nfqusv 95 6 room room NN cord-271526-14nfqusv 95 7 temperature temperature NN cord-271526-14nfqusv 95 8 for for IN cord-271526-14nfqusv 95 9 20 20 CD cord-271526-14nfqusv 95 10 min min NN cord-271526-14nfqusv 95 11 , , , cord-271526-14nfqusv 95 12 after after IN cord-271526-14nfqusv 95 13 which which WDT cord-271526-14nfqusv 95 14 5 5 CD cord-271526-14nfqusv 95 15 ml ml NNS cord-271526-14nfqusv 95 16 of of IN cord-271526-14nfqusv 95 17 50 50 CD cord-271526-14nfqusv 95 18 % % NN cord-271526-14nfqusv 95 19 glycerol glycerol NN cord-271526-14nfqusv 95 20 ( ( -LRB- cord-271526-14nfqusv 95 21 ii ii NN cord-271526-14nfqusv 95 22 ) ) -RRB- cord-271526-14nfqusv 96 1 Protein protein NN cord-271526-14nfqusv 96 2 lysates lysate NNS cord-271526-14nfqusv 96 3 from from IN cord-271526-14nfqusv 96 4 purified purify VBN cord-271526-14nfqusv 96 5 viruses virus NNS cord-271526-14nfqusv 96 6 . . . cord-271526-14nfqusv 97 1 Virus virus NN cord-271526-14nfqusv 97 2 was be VBD cord-271526-14nfqusv 97 3 purified purify VBN cord-271526-14nfqusv 97 4 as as IN cord-271526-14nfqusv 97 5 described describe VBN cord-271526-14nfqusv 97 6 before before IN cord-271526-14nfqusv 97 7 ( ( -LRB- cord-271526-14nfqusv 97 8 Luytjes Luytjes NNP cord-271526-14nfqusv 97 9 et et NNP cord-271526-14nfqusv 97 10 al al NNP cord-271526-14nfqusv 97 11 . . NNP cord-271526-14nfqusv 97 12 , , , cord-271526-14nfqusv 97 13 1997 1997 CD cord-271526-14nfqusv 97 14 ) ) -RRB- cord-271526-14nfqusv 97 15 . . . cord-271526-14nfqusv 98 1 Briefly briefly RB cord-271526-14nfqusv 98 2 , , , cord-271526-14nfqusv 98 3 was be VBD cord-271526-14nfqusv 98 4 added add VBN cord-271526-14nfqusv 98 5 to to IN cord-271526-14nfqusv 98 6 each each DT cord-271526-14nfqusv 98 7 reaction reaction NN cord-271526-14nfqusv 98 8 . . . cord-271526-14nfqusv 99 1 The the DT cord-271526-14nfqusv 99 2 mixtures mixture NNS cord-271526-14nfqusv 99 3 were be VBD cord-271526-14nfqusv 99 4 then then RB cord-271526-14nfqusv 99 5 separated separate VBN cord-271526-14nfqusv 99 6 by by IN cord-271526-14nfqusv 99 7 electrophoresis electrophoresis NN cord-271526-14nfqusv 99 8 on on IN cord-271526-14nfqusv 99 9 a a DT cord-271526-14nfqusv 99 10 5 5 CD cord-271526-14nfqusv 99 11 % % NN cord-271526-14nfqusv 99 12 polyacrylamide/ polyacrylamide/ NNS cord-271526-14nfqusv 99 13 viruses virus NNS cord-271526-14nfqusv 99 14 harvested harvest VBN cord-271526-14nfqusv 99 15 from from IN cord-271526-14nfqusv 99 16 8 8 CD cord-271526-14nfqusv 99 17 1 1 CD cord-271526-14nfqusv 99 18 10 10 CD cord-271526-14nfqusv 99 19 7 7 CD cord-271526-14nfqusv 99 20 cells cell NNS cord-271526-14nfqusv 99 21 were be VBD cord-271526-14nfqusv 99 22 precipitated precipitate VBN cord-271526-14nfqusv 99 23 with with IN cord-271526-14nfqusv 99 24 polyethylene polyethylene NN cord-271526-14nfqusv 99 25 glycol glycol NN cord-271526-14nfqusv 99 26 and and CC cord-271526-14nfqusv 99 27 loaded load VBN cord-271526-14nfqusv 99 28 on on IN cord-271526-14nfqusv 99 29 top top NN cord-271526-14nfqusv 99 30 of of IN cord-271526-14nfqusv 99 31 a a DT cord-271526-14nfqusv 99 32 20 20 CD cord-271526-14nfqusv 99 33 to to TO cord-271526-14nfqusv 99 34 50 50 CD cord-271526-14nfqusv 99 35 % % NN cord-271526-14nfqusv 99 36 10 10 CD cord-271526-14nfqusv 99 37 % % NN cord-271526-14nfqusv 99 38 glycerol glycerol NN cord-271526-14nfqusv 99 39 gel gel NN cord-271526-14nfqusv 99 40 ( ( -LRB- cord-271526-14nfqusv 99 41 mono mono NN cord-271526-14nfqusv 99 42 : : : cord-271526-14nfqusv 99 43 bis bis NNP cord-271526-14nfqusv 99 44 Å å NN cord-271526-14nfqusv 99 45 37.5:1 37.5:1 CD cord-271526-14nfqusv 99 46 ) ) -RRB- cord-271526-14nfqusv 99 47 in in IN cord-271526-14nfqusv 99 48 0.51 0.51 CD cord-271526-14nfqusv 99 49 TBE TBE NNP cord-271526-14nfqusv 99 50 ( ( -LRB- cord-271526-14nfqusv 99 51 45 45 CD cord-271526-14nfqusv 99 52 mM mM NNP cord-271526-14nfqusv 99 53 Tris Tris NNP cord-271526-14nfqusv 99 54 - - HYPH cord-271526-14nfqusv 99 55 Cl Cl NNP cord-271526-14nfqusv 99 56 ( ( -LRB- cord-271526-14nfqusv 99 57 pH pH NNP cord-271526-14nfqusv 99 58 7.5 7.5 CD cord-271526-14nfqusv 99 59 ) ) -RRB- cord-271526-14nfqusv 99 60 ) ) -RRB- cord-271526-14nfqusv 99 61 , , , cord-271526-14nfqusv 99 62 45 45 CD cord-271526-14nfqusv 99 63 mM mm CD cord-271526-14nfqusv 99 64 boric boric NN cord-271526-14nfqusv 99 65 acid acid NN cord-271526-14nfqusv 99 66 , , , cord-271526-14nfqusv 99 67 1 1 CD cord-271526-14nfqusv 99 68 mM mm CD cord-271526-14nfqusv 99 69 EDTA EDTA NNP cord-271526-14nfqusv 99 70 ) ) -RRB- cord-271526-14nfqusv 99 71 for for IN cord-271526-14nfqusv 99 72 6 6 CD cord-271526-14nfqusv 99 73 linear linear JJ cord-271526-14nfqusv 99 74 sucrose sucrose NN cord-271526-14nfqusv 99 75 gradient gradient NN cord-271526-14nfqusv 99 76 . . . cord-271526-14nfqusv 100 1 The the DT cord-271526-14nfqusv 100 2 gradient gradient NN cord-271526-14nfqusv 100 3 was be VBD cord-271526-14nfqusv 100 4 centrifuged centrifuge VBN cord-271526-14nfqusv 100 5 for for IN cord-271526-14nfqusv 100 6 16 16 CD cord-271526-14nfqusv 100 7 h h NN cord-271526-14nfqusv 100 8 at at IN cord-271526-14nfqusv 100 9 16,000 16,000 CD cord-271526-14nfqusv 100 10 rpm rpm NN cord-271526-14nfqusv 100 11 at at IN cord-271526-14nfqusv 100 12 4Њ 4њ CD cord-271526-14nfqusv 100 13 in in IN cord-271526-14nfqusv 100 14 a a DT cord-271526-14nfqusv 100 15 SW40Ti SW40Ti NNP cord-271526-14nfqusv 100 16 rotor rotor NN cord-271526-14nfqusv 100 17 . . . cord-271526-14nfqusv 101 1 Subsequently subsequently RB cord-271526-14nfqusv 101 2 h h NNP cord-271526-14nfqusv 101 3 at at IN cord-271526-14nfqusv 101 4 5 5 CD cord-271526-14nfqusv 101 5 mA mA NNP cord-271526-14nfqusv 101 6 ( ( -LRB- cord-271526-14nfqusv 101 7 fixed fix VBN cord-271526-14nfqusv 101 8 ) ) -RRB- cord-271526-14nfqusv 101 9 . . . cord-271526-14nfqusv 102 1 Subsequently subsequently RB cord-271526-14nfqusv 102 2 , , , cord-271526-14nfqusv 102 3 the the DT cord-271526-14nfqusv 102 4 gel gel NN cord-271526-14nfqusv 102 5 was be VBD cord-271526-14nfqusv 102 6 dried dry VBN cord-271526-14nfqusv 102 7 and and CC cord-271526-14nfqusv 102 8 exposed expose VBN cord-271526-14nfqusv 102 9 to to IN cord-271526-14nfqusv 102 10 X x NN cord-271526-14nfqusv 102 11 - - NN cord-271526-14nfqusv 102 12 ray ray JJ cord-271526-14nfqusv 102 13 film film NN cord-271526-14nfqusv 102 14 with with IN cord-271526-14nfqusv 102 15 an an DT cord-271526-14nfqusv 102 16 intensifying intensify VBG cord-271526-14nfqusv 102 17 screen screen NN cord-271526-14nfqusv 102 18 at at IN cord-271526-14nfqusv 102 19 080Њ. 080Њ. NNP cord-271526-14nfqusv 103 1 the the DT cord-271526-14nfqusv 103 2 gradient gradient NN cord-271526-14nfqusv 103 3 was be VBD cord-271526-14nfqusv 103 4 fractioned fraction VBN cord-271526-14nfqusv 103 5 into into IN cord-271526-14nfqusv 103 6 16 16 CD cord-271526-14nfqusv 103 7 fractions fraction NNS cord-271526-14nfqusv 103 8 . . . cord-271526-14nfqusv 104 1 All all DT cord-271526-14nfqusv 104 2 fractions fraction NNS cord-271526-14nfqusv 104 3 were be VBD cord-271526-14nfqusv 104 4 assayed assay VBN cord-271526-14nfqusv 104 5 for for IN cord-271526-14nfqusv 104 6 viral viral JJ cord-271526-14nfqusv 104 7 proteins protein NNS cord-271526-14nfqusv 104 8 by by IN cord-271526-14nfqusv 104 9 Western western JJ cord-271526-14nfqusv 104 10 blot blot NN cord-271526-14nfqusv 104 11 using use VBG cord-271526-14nfqusv 104 12 UV uv NN cord-271526-14nfqusv 104 13 cross cross NN cord-271526-14nfqusv 104 14 - - JJ cord-271526-14nfqusv 104 15 linking link VBG cord-271526-14nfqusv 104 16 the the DT cord-271526-14nfqusv 104 17 rabbit rabbit NN cord-271526-14nfqusv 104 18 polyclonal polyclonal JJ cord-271526-14nfqusv 104 19 MHV MHV NNP cord-271526-14nfqusv 104 20 - - HYPH cord-271526-14nfqusv 104 21 A59 A59 NNP cord-271526-14nfqusv 104 22 antiserum antiserum NN cord-271526-14nfqusv 104 23 k134 k134 NN cord-271526-14nfqusv 104 24 . . . cord-271526-14nfqusv 105 1 The the DT cord-271526-14nfqusv 105 2 two two CD cord-271526-14nfqusv 105 3 fractions fraction NNS cord-271526-14nfqusv 105 4 corresponding correspond VBG cord-271526-14nfqusv 105 5 to to IN cord-271526-14nfqusv 105 6 the the DT cord-271526-14nfqusv 105 7 virus virus NN cord-271526-14nfqusv 105 8 peak peak NN cord-271526-14nfqusv 105 9 and and CC cord-271526-14nfqusv 105 10 two two CD cord-271526-14nfqusv 105 11 bottom bottom NN cord-271526-14nfqusv 105 12 RNA RNA NNP cord-271526-14nfqusv 105 13 binding binding NN cord-271526-14nfqusv 105 14 reactions reaction NNS cord-271526-14nfqusv 105 15 were be VBD cord-271526-14nfqusv 105 16 performed perform VBN cord-271526-14nfqusv 105 17 as as IN cord-271526-14nfqusv 105 18 described described JJ cord-271526-14nfqusv 105 19 fractions fraction NNS cord-271526-14nfqusv 105 20 ( ( -LRB- cord-271526-14nfqusv 105 21 control control NN cord-271526-14nfqusv 105 22 ) ) -RRB- cord-271526-14nfqusv 105 23 were be VBD cord-271526-14nfqusv 105 24 combined combine VBN cord-271526-14nfqusv 105 25 , , , cord-271526-14nfqusv 105 26 and and CC cord-271526-14nfqusv 105 27 their -PRON- PRP$ cord-271526-14nfqusv 105 28 volumes volume NNS cord-271526-14nfqusv 105 29 above above RB cord-271526-14nfqusv 105 30 . . . cord-271526-14nfqusv 106 1 Subsequently subsequently RB cord-271526-14nfqusv 106 2 the the DT cord-271526-14nfqusv 106 3 samples sample NNS cord-271526-14nfqusv 106 4 were be VBD cord-271526-14nfqusv 106 5 irradiated irradiate VBN cord-271526-14nfqusv 106 6 at at IN cord-271526-14nfqusv 106 7 a a DT cord-271526-14nfqusv 106 8 were be VBD cord-271526-14nfqusv 106 9 adjusted adjust VBN cord-271526-14nfqusv 106 10 to to IN cord-271526-14nfqusv 106 11 5 5 CD cord-271526-14nfqusv 106 12 ml ml NNS cord-271526-14nfqusv 106 13 with with IN cord-271526-14nfqusv 106 14 TESV TESV NNP cord-271526-14nfqusv 106 15 ( ( -LRB- cord-271526-14nfqusv 106 16 20 20 CD cord-271526-14nfqusv 106 17 mM mM NNP cord-271526-14nfqusv 106 18 Tris Tris NNP cord-271526-14nfqusv 106 19 ( ( -LRB- cord-271526-14nfqusv 106 20 pH pH NNP cord-271526-14nfqusv 106 21 7.4 7.4 CD cord-271526-14nfqusv 106 22 ) ) -RRB- cord-271526-14nfqusv 106 23 , , , cord-271526-14nfqusv 106 24 2-cm 2-cm CD cord-271526-14nfqusv 106 25 distance distance NN cord-271526-14nfqusv 106 26 with with IN cord-271526-14nfqusv 106 27 1.8 1.8 CD cord-271526-14nfqusv 106 28 J J NNP cord-271526-14nfqusv 106 29 / / SYM cord-271526-14nfqusv 106 30 cm cm NNP cord-271526-14nfqusv 106 31 2 2 CD cord-271526-14nfqusv 106 32 of of IN cord-271526-14nfqusv 106 33 254-nm 254-nm CD cord-271526-14nfqusv 106 34 UV uv NN cord-271526-14nfqusv 106 35 light light NN cord-271526-14nfqusv 106 36 in in IN cord-271526-14nfqusv 106 37 a a DT cord-271526-14nfqusv 106 38 1 1 CD cord-271526-14nfqusv 106 39 mM mm CD cord-271526-14nfqusv 106 40 EDTA EDTA NNP cord-271526-14nfqusv 106 41 , , , cord-271526-14nfqusv 106 42 100 100 CD cord-271526-14nfqusv 106 43 mM mm CD cord-271526-14nfqusv 106 44 NaCl nacl NN cord-271526-14nfqusv 106 45 ) ) -RRB- cord-271526-14nfqusv 106 46 . . . cord-271526-14nfqusv 107 1 Virus virus NN cord-271526-14nfqusv 107 2 was be VBD cord-271526-14nfqusv 107 3 pelleted pellete VBN cord-271526-14nfqusv 107 4 by by IN cord-271526-14nfqusv 107 5 centrif centrif NNP cord-271526-14nfqusv 107 6 - - HYPH cord-271526-14nfqusv 107 7 Stratalinker Stratalinker NNP cord-271526-14nfqusv 107 8 1800 1800 CD cord-271526-14nfqusv 107 9 ( ( -LRB- cord-271526-14nfqusv 107 10 Stratagene Stratagene NNP cord-271526-14nfqusv 107 11 ) ) -RRB- cord-271526-14nfqusv 107 12 . . . cord-271526-14nfqusv 108 1 The the DT cord-271526-14nfqusv 108 2 complexes complex NNS cord-271526-14nfqusv 108 3 were be VBD cord-271526-14nfqusv 108 4 then then RB cord-271526-14nfqusv 108 5 ugation ugation NN cord-271526-14nfqusv 108 6 in in IN cord-271526-14nfqusv 108 7 a a DT cord-271526-14nfqusv 108 8 SW55Ti SW55Ti NNP cord-271526-14nfqusv 108 9 rotor rotor NN cord-271526-14nfqusv 108 10 for for IN cord-271526-14nfqusv 108 11 3 3 CD cord-271526-14nfqusv 108 12 h h NN cord-271526-14nfqusv 108 13 at at IN cord-271526-14nfqusv 108 14 35,000 35,000 CD cord-271526-14nfqusv 108 15 rpm rpm NN cord-271526-14nfqusv 108 16 at at IN cord-271526-14nfqusv 108 17 4Њ. 4њ. CD cord-271526-14nfqusv 108 18 incubated incubate VBN cord-271526-14nfqusv 108 19 with with IN cord-271526-14nfqusv 108 20 a a DT cord-271526-14nfqusv 108 21 mixture mixture NN cord-271526-14nfqusv 108 22 of of IN cord-271526-14nfqusv 108 23 500 500 CD cord-271526-14nfqusv 108 24 ng ng NN cord-271526-14nfqusv 108 25 RNase RNase NNP cord-271526-14nfqusv 108 26 A A NNP cord-271526-14nfqusv 108 27 ( ( -LRB- cord-271526-14nfqusv 108 28 Pharmacia Pharmacia NNP cord-271526-14nfqusv 108 29 ) ) -RRB- cord-271526-14nfqusv 109 1 The the DT cord-271526-14nfqusv 109 2 resulting result VBG cord-271526-14nfqusv 109 3 virus virus NN cord-271526-14nfqusv 109 4 pellet pellet NN cord-271526-14nfqusv 109 5 was be VBD cord-271526-14nfqusv 109 6 lysed lyse VBN cord-271526-14nfqusv 109 7 in in IN cord-271526-14nfqusv 109 8 100 100 CD cord-271526-14nfqusv 109 9 ml ml NN cord-271526-14nfqusv 109 10 buffer buffer NN cord-271526-14nfqusv 109 11 C c NN cord-271526-14nfqusv 109 12 and and CC cord-271526-14nfqusv 109 13 2.5 2.5 CD cord-271526-14nfqusv 109 14 units unit NNS cord-271526-14nfqusv 109 15 RNase RNase NNP cord-271526-14nfqusv 109 16 T1 T1 NNP cord-271526-14nfqusv 109 17 ( ( -LRB- cord-271526-14nfqusv 109 18 Gibco Gibco NNP cord-271526-14nfqusv 109 19 BRL BRL NNP cord-271526-14nfqusv 109 20 ) ) -RRB- cord-271526-14nfqusv 109 21 for for IN cord-271526-14nfqusv 109 22 20 20 CD cord-271526-14nfqusv 109 23 min min NN cord-271526-14nfqusv 109 24 at at IN cord-271526-14nfqusv 109 25 37Њ. 37њ. CD cord-271526-14nfqusv 110 1 The the DT cord-271526-14nfqusv 110 2 supplemented supplement VBN cord-271526-14nfqusv 110 3 with with IN cord-271526-14nfqusv 110 4 0.5 0.5 CD cord-271526-14nfqusv 110 5 % % NN cord-271526-14nfqusv 110 6 NP-40 NP-40 NNP cord-271526-14nfqusv 110 7 . . . cord-271526-14nfqusv 111 1 complexes complex NNS cord-271526-14nfqusv 111 2 were be VBD cord-271526-14nfqusv 111 3 analyzed analyze VBN cord-271526-14nfqusv 111 4 by by IN cord-271526-14nfqusv 111 5 sodium sodium NN cord-271526-14nfqusv 111 6 dodecyl dodecyl NNP cord-271526-14nfqusv 111 7 sulfate-(iii sulfate-(iii NNP cord-271526-14nfqusv 111 8 ) ) -RRB- cord-271526-14nfqusv 112 1 Recombinant Recombinant NNP cord-271526-14nfqusv 112 2 N N NNP cord-271526-14nfqusv 112 3 protein protein NN cord-271526-14nfqusv 112 4 lysates lysate NNS cord-271526-14nfqusv 112 5 . . . cord-271526-14nfqusv 113 1 Vaccinia vaccinia NN cord-271526-14nfqusv 113 2 virus virus NN cord-271526-14nfqusv 113 3 inpolyacrylamide inpolyacrylamide NN cord-271526-14nfqusv 113 4 gel gel NN cord-271526-14nfqusv 113 5 electrophoresis electrophoresis NN cord-271526-14nfqusv 113 6 on on IN cord-271526-14nfqusv 113 7 15 15 CD cord-271526-14nfqusv 113 8 % % NN cord-271526-14nfqusv 113 9 gels gel NNS cord-271526-14nfqusv 113 10 . . . cord-271526-14nfqusv 114 1 fections fections NNP cord-271526-14nfqusv 114 2 and and CC cord-271526-14nfqusv 114 3 DNA DNA NNP cord-271526-14nfqusv 114 4 transfections transfection NNS cord-271526-14nfqusv 114 5 were be VBD cord-271526-14nfqusv 114 6 performed perform VBN cord-271526-14nfqusv 114 7 as as IN cord-271526-14nfqusv 114 8 de de NNP cord-271526-14nfqusv 114 9 - - NN cord-271526-14nfqusv 114 10 Alternatively alternatively RB cord-271526-14nfqusv 114 11 , , , cord-271526-14nfqusv 114 12 cross cross NN cord-271526-14nfqusv 114 13 - - VBN cord-271526-14nfqusv 114 14 linked link VBN cord-271526-14nfqusv 114 15 and and CC cord-271526-14nfqusv 114 16 RNase rnase NN cord-271526-14nfqusv 114 17 treated treat VBD cord-271526-14nfqusv 114 18 samples sample NNS cord-271526-14nfqusv 114 19 scribed scribe VBN cord-271526-14nfqusv 114 20 previously previously RB cord-271526-14nfqusv 114 21 . . . cord-271526-14nfqusv 115 1 Briefly briefly RB cord-271526-14nfqusv 115 2 , , , cord-271526-14nfqusv 115 3 RK13 RK13 NNP cord-271526-14nfqusv 115 4 cells cell NNS cord-271526-14nfqusv 115 5 were be VBD cord-271526-14nfqusv 115 6 immunoprecipitated immunoprecipitate VBN cord-271526-14nfqusv 115 7 prior prior RB cord-271526-14nfqusv 115 8 to to IN cord-271526-14nfqusv 115 9 electrophoresis electrophoresis NN cord-271526-14nfqusv 115 10 as as IN cord-271526-14nfqusv 115 11 dewere dewere NNP cord-271526-14nfqusv 115 12 grown grow VBN cord-271526-14nfqusv 115 13 to to IN cord-271526-14nfqusv 115 14 subconfluency subconfluency NN cord-271526-14nfqusv 115 15 in in IN cord-271526-14nfqusv 115 16 5-cm 5-cm CD cord-271526-14nfqusv 115 17 - - HYPH cord-271526-14nfqusv 115 18 diameter diameter NN cord-271526-14nfqusv 115 19 petri petri NN cord-271526-14nfqusv 115 20 scribed scribe VBN cord-271526-14nfqusv 115 21 earlier early RBR cord-271526-14nfqusv 115 22 with with IN cord-271526-14nfqusv 115 23 monoclonal monoclonal JJ cord-271526-14nfqusv 115 24 antidishes antidishe NNS cord-271526-14nfqusv 115 25 ( ( -LRB- cord-271526-14nfqusv 115 26 4 4 CD cord-271526-14nfqusv 115 27 1 1 CD cord-271526-14nfqusv 115 28 10 10 CD cord-271526-14nfqusv 115 29 6 6 CD cord-271526-14nfqusv 115 30 cells cell NNS cord-271526-14nfqusv 115 31 per per IN cord-271526-14nfqusv 115 32 dish dish NN cord-271526-14nfqusv 115 33 ) ) -RRB- cord-271526-14nfqusv 115 34 and and CC cord-271526-14nfqusv 115 35 infected infect VBN cord-271526-14nfqusv 115 36 with with IN cord-271526-14nfqusv 115 37 the the DT cord-271526-14nfqusv 115 38 T7 T7 NNP cord-271526-14nfqusv 115 39 body body NN cord-271526-14nfqusv 115 40 5B188.2 5b188.2 CD cord-271526-14nfqusv 116 1 ( ( -LRB- cord-271526-14nfqusv 116 2 Talbot Talbot NNP cord-271526-14nfqusv 116 3 and and CC cord-271526-14nfqusv 116 4 Buchmeier Buchmeier NNP cord-271526-14nfqusv 116 5 , , , cord-271526-14nfqusv 116 6 1985 1985 CD cord-271526-14nfqusv 116 7 ) ) -RRB- cord-271526-14nfqusv 116 8 or or CC cord-271526-14nfqusv 116 9 rabbit rabbit NN cord-271526-14nfqusv 116 10 RNA RNA NNP cord-271526-14nfqusv 116 11 polymerase polymerase NN cord-271526-14nfqusv 116 12 expressing express VBG cord-271526-14nfqusv 116 13 vaccinia vaccinia NN cord-271526-14nfqusv 116 14 virus virus NN cord-271526-14nfqusv 116 15 recombinant recombinant JJ cord-271526-14nfqusv 116 16 polyclonal polyclonal JJ cord-271526-14nfqusv 116 17 MHV MHV NNP cord-271526-14nfqusv 116 18 - - HYPH cord-271526-14nfqusv 116 19 A59 A59 NNP cord-271526-14nfqusv 116 20 antiserum antiserum NN cord-271526-14nfqusv 116 21 k134 k134 NN cord-271526-14nfqusv 116 22 . . . cord-271526-14nfqusv 117 1 ( ( -LRB- cord-271526-14nfqusv 117 2 vTF7.3 vTF7.3 NNP cord-271526-14nfqusv 117 3 ) ) -RRB- cord-271526-14nfqusv 117 4 at at IN cord-271526-14nfqusv 117 5 a a DT cord-271526-14nfqusv 117 6 m.o.i m.o.i NN cord-271526-14nfqusv 117 7 . . NN cord-271526-14nfqusv 117 8 of of IN cord-271526-14nfqusv 117 9 5 5 CD cord-271526-14nfqusv 117 10 . . . cord-271526-14nfqusv 118 1 At at IN cord-271526-14nfqusv 118 2 1 1 CD cord-271526-14nfqusv 118 3 h h NN cord-271526-14nfqusv 118 4 postinfection postinfection NN cord-271526-14nfqusv 118 5 the the DT cord-271526-14nfqusv 118 6 cells cell NNS cord-271526-14nfqusv 118 7 were be VBD cord-271526-14nfqusv 118 8 transfected transfecte VBN cord-271526-14nfqusv 118 9 with with IN cord-271526-14nfqusv 118 10 20 20 CD cord-271526-14nfqusv 118 11 ml ml NN cord-271526-14nfqusv 118 12 lipofectin lipofectin NN cord-271526-14nfqusv 118 13 ( ( -LRB- cord-271526-14nfqusv 118 14 Gibco Gibco NNP cord-271526-14nfqusv 118 15 BRL BRL NNP cord-271526-14nfqusv 118 16 ) ) -RRB- cord-271526-14nfqusv 118 17 containing contain VBG cord-271526-14nfqusv 118 18 5 5 CD cord-271526-14nfqusv 118 19 RESULTS result NNS cord-271526-14nfqusv 118 20 mg mg PRP cord-271526-14nfqusv 118 21 of of IN cord-271526-14nfqusv 118 22 pEMCV pEMCV NNP cord-271526-14nfqusv 118 23 - - HYPH cord-271526-14nfqusv 118 24 N. n. NN cord-271526-14nfqusv 118 25 After after IN cord-271526-14nfqusv 118 26 an an DT cord-271526-14nfqusv 118 27 incubation incubation NN cord-271526-14nfqusv 118 28 of of IN cord-271526-14nfqusv 118 29 16 16 CD cord-271526-14nfqusv 118 30 h h NN cord-271526-14nfqusv 118 31 protein protein NN cord-271526-14nfqusv 118 32 ly ly NNP cord-271526-14nfqusv 118 33 - - HYPH cord-271526-14nfqusv 118 34 Ps290 Ps290 NNP cord-271526-14nfqusv 118 35 RNA RNA NNP cord-271526-14nfqusv 118 36 binds bind VBZ cord-271526-14nfqusv 118 37 specifically specifically RB cord-271526-14nfqusv 118 38 to to IN cord-271526-14nfqusv 118 39 proteins protein NNS cord-271526-14nfqusv 118 40 from from IN cord-271526-14nfqusv 118 41 MHVsates mhvsate NNS cord-271526-14nfqusv 118 42 were be VBD cord-271526-14nfqusv 118 43 made make VBN cord-271526-14nfqusv 118 44 as as IN cord-271526-14nfqusv 118 45 described describe VBN cord-271526-14nfqusv 118 46 above above RB cord-271526-14nfqusv 118 47 . . . cord-271526-14nfqusv 119 1 infected infected JJ cord-271526-14nfqusv 119 2 and and CC cord-271526-14nfqusv 119 3 mock mock JJ cord-271526-14nfqusv 119 4 - - HYPH cord-271526-14nfqusv 119 5 infected infect VBN cord-271526-14nfqusv 119 6 cells cell NNS cord-271526-14nfqusv 120 1 Gel gel NN cord-271526-14nfqusv 120 2 mobility mobility NN cord-271526-14nfqusv 120 3 shift shift NN cord-271526-14nfqusv 120 4 assays assay NNS cord-271526-14nfqusv 121 1 In in IN cord-271526-14nfqusv 121 2 the the DT cord-271526-14nfqusv 121 3 studies study NNS cord-271526-14nfqusv 121 4 described describe VBN cord-271526-14nfqusv 121 5 here here RB cord-271526-14nfqusv 121 6 we -PRON- PRP cord-271526-14nfqusv 121 7 have have VBP cord-271526-14nfqusv 121 8 analyzed analyze VBN cord-271526-14nfqusv 121 9 the the DT cord-271526-14nfqusv 121 10 interaction interaction NN cord-271526-14nfqusv 121 11 between between IN cord-271526-14nfqusv 121 12 the the DT cord-271526-14nfqusv 121 13 MHV MHV NNP cord-271526-14nfqusv 121 14 - - HYPH cord-271526-14nfqusv 121 15 A59 A59 NNP cord-271526-14nfqusv 121 16 N N NNP cord-271526-14nfqusv 121 17 protein protein NN cord-271526-14nfqusv 121 18 and and CC cord-271526-14nfqusv 121 19 RNAs RNAs NNP cord-271526-14nfqusv 121 20 RNA RNA NNP cord-271526-14nfqusv 121 21 binding binding NN cord-271526-14nfqusv 121 22 reactions reaction NNS cord-271526-14nfqusv 121 23 contained contain VBD cord-271526-14nfqusv 121 24 10 10 CD cord-271526-14nfqusv 121 25 ng ng NN cord-271526-14nfqusv 121 26 of of IN cord-271526-14nfqusv 121 27 radiolabeled radiolabele VBN cord-271526-14nfqusv 121 28 riboprobe riboprobe NNP cord-271526-14nfqusv 121 29 and and CC cord-271526-14nfqusv 121 30 4 4 CD cord-271526-14nfqusv 121 31 mg mg NN cord-271526-14nfqusv 121 32 of of IN cord-271526-14nfqusv 121 33 protein protein NN cord-271526-14nfqusv 121 34 lysate lysate NN cord-271526-14nfqusv 121 35 in in IN cord-271526-14nfqusv 121 36 a a DT cord-271526-14nfqusv 121 37 final final JJ cord-271526-14nfqusv 121 38 volume volume NN cord-271526-14nfqusv 121 39 of of IN cord-271526-14nfqusv 121 40 containing contain VBG cord-271526-14nfqusv 121 41 the the DT cord-271526-14nfqusv 121 42 69-nt 69-nt CD cord-271526-14nfqusv 122 1 Ps ps NN cord-271526-14nfqusv 122 2 signal signal NN cord-271526-14nfqusv 122 3 . . . cord-271526-14nfqusv 123 1 In in IN cord-271526-14nfqusv 123 2 order order NN cord-271526-14nfqusv 123 3 to to TO cord-271526-14nfqusv 123 4 identify identify VB cord-271526-14nfqusv 123 5 this this DT cord-271526-14nfqusv 123 6 15 15 CD cord-271526-14nfqusv 123 7 ) ) -RRB- cord-271526-14nfqusv 123 8 . . . cord-271526-14nfqusv 124 1 These these DT cord-271526-14nfqusv 124 2 observations observation NNS cord-271526-14nfqusv 124 3 indicate indicate VBP cord-271526-14nfqusv 124 4 that that IN cord-271526-14nfqusv 124 5 there there EX cord-271526-14nfqusv 124 6 is be VBZ cord-271526-14nfqusv 124 7 a a DT cord-271526-14nfqusv 124 8 specific specific JJ cord-271526-14nfqusv 124 9 interaction interaction NN cord-271526-14nfqusv 124 10 between between IN cord-271526-14nfqusv 124 11 Ps290 Ps290 NNP cord-271526-14nfqusv 124 12 RNA RNA NNP cord-271526-14nfqusv 124 13 and and CC cord-271526-14nfqusv 124 14 proteins protein NNS cord-271526-14nfqusv 124 15 from from IN cord-271526-14nfqusv 124 16 MHVinfected mhvinfected JJ cord-271526-14nfqusv 124 17 cells cell NNS cord-271526-14nfqusv 124 18 as as RB cord-271526-14nfqusv 124 19 well well RB cord-271526-14nfqusv 124 20 as as IN cord-271526-14nfqusv 124 21 with with IN cord-271526-14nfqusv 124 22 proteins protein NNS cord-271526-14nfqusv 124 23 from from IN cord-271526-14nfqusv 124 24 mock mock JJ cord-271526-14nfqusv 124 25 - - HYPH cord-271526-14nfqusv 124 26 infected infect VBN cord-271526-14nfqusv 124 27 cells cell NNS cord-271526-14nfqusv 124 28 . . . cord-271526-14nfqusv 125 1 The the DT cord-271526-14nfqusv 125 2 MHV MHV NNP cord-271526-14nfqusv 125 3 - - HYPH cord-271526-14nfqusv 125 4 A59 A59 NNP cord-271526-14nfqusv 125 5 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 125 6 protein protein NN cord-271526-14nfqusv 125 7 interacts interact VBZ cord-271526-14nfqusv 125 8 specifically specifically RB cord-271526-14nfqusv 125 9 with with IN cord-271526-14nfqusv 125 10 Ps290 Ps290 NNP cord-271526-14nfqusv 125 11 RNA RNA NNP cord-271526-14nfqusv 125 12 To to TO cord-271526-14nfqusv 125 13 investigate investigate VB cord-271526-14nfqusv 125 14 whether whether IN cord-271526-14nfqusv 125 15 the the DT cord-271526-14nfqusv 125 16 N N NNP cord-271526-14nfqusv 125 17 protein protein NN cord-271526-14nfqusv 125 18 is be VBZ cord-271526-14nfqusv 125 19 part part NN cord-271526-14nfqusv 125 20 of of IN cord-271526-14nfqusv 125 21 the the DT cord-271526-14nfqusv 125 22 protein protein NN cord-271526-14nfqusv 125 23 - - HYPH cord-271526-14nfqusv 125 24 Ps290 Ps290 NNP cord-271526-14nfqusv 125 25 RNA RNA NNP cord-271526-14nfqusv 125 26 complex complex NN cord-271526-14nfqusv 125 27 , , , cord-271526-14nfqusv 125 28 a a DT cord-271526-14nfqusv 125 29 supershift supershift NN cord-271526-14nfqusv 125 30 assay assay NN cord-271526-14nfqusv 125 31 using use VBG cord-271526-14nfqusv 125 32 a a DT cord-271526-14nfqusv 125 33 N n CD cord-271526-14nfqusv 125 34 - - HYPH cord-271526-14nfqusv 125 35 specific specific JJ cord-271526-14nfqusv 125 36 antibody antibody NN cord-271526-14nfqusv 125 37 was be VBD cord-271526-14nfqusv 125 38 performed perform VBN cord-271526-14nfqusv 125 39 . . . cord-271526-14nfqusv 126 1 If if IN cord-271526-14nfqusv 126 2 the the DT cord-271526-14nfqusv 126 3 N N NNP cord-271526-14nfqusv 126 4 protein protein NN cord-271526-14nfqusv 126 5 is be VBZ cord-271526-14nfqusv 126 6 indeed indeed RB cord-271526-14nfqusv 126 7 part part NN cord-271526-14nfqusv 126 8 of of IN cord-271526-14nfqusv 126 9 the the DT cord-271526-14nfqusv 126 10 complex complex NN cord-271526-14nfqusv 126 11 , , , cord-271526-14nfqusv 126 12 binding bind VBG cord-271526-14nfqusv 126 13 to to IN cord-271526-14nfqusv 126 14 N n CD cord-271526-14nfqusv 126 15 of of IN cord-271526-14nfqusv 126 16 a a DT cord-271526-14nfqusv 126 17 N n CD cord-271526-14nfqusv 126 18 - - HYPH cord-271526-14nfqusv 126 19 specific specific JJ cord-271526-14nfqusv 126 20 antibody antibody NN cord-271526-14nfqusv 126 21 should should MD cord-271526-14nfqusv 126 22 result result VB cord-271526-14nfqusv 126 23 in in IN cord-271526-14nfqusv 126 24 the the DT cord-271526-14nfqusv 126 25 formation formation NN cord-271526-14nfqusv 126 26 of of IN cord-271526-14nfqusv 126 27 a a DT cord-271526-14nfqusv 126 28 large large JJ cord-271526-14nfqusv 126 29 complex complex NN cord-271526-14nfqusv 126 30 composed compose VBN cord-271526-14nfqusv 126 31 of of IN cord-271526-14nfqusv 126 32 Ps290 Ps290 NNP cord-271526-14nfqusv 126 33 RNA RNA NNP cord-271526-14nfqusv 126 34 , , , cord-271526-14nfqusv 126 35 N N NNP cord-271526-14nfqusv 126 36 protein protein NN cord-271526-14nfqusv 126 37 , , , cord-271526-14nfqusv 126 38 and and CC cord-271526-14nfqusv 126 39 N n CD cord-271526-14nfqusv 126 40 - - HYPH cord-271526-14nfqusv 126 41 specific specific JJ cord-271526-14nfqusv 126 42 antibody antibody NN cord-271526-14nfqusv 126 43 . . . cord-271526-14nfqusv 127 1 This this DT cord-271526-14nfqusv 127 2 complex complex NN cord-271526-14nfqusv 127 3 is be VBZ cord-271526-14nfqusv 127 4 expected expect VBN cord-271526-14nfqusv 127 5 to to TO cord-271526-14nfqusv 127 6 migrate migrate VB cord-271526-14nfqusv 127 7 slower slow RBR cord-271526-14nfqusv 127 8 in in IN cord-271526-14nfqusv 127 9 the the DT cord-271526-14nfqusv 127 10 gel gel NN cord-271526-14nfqusv 127 11 as as IN cord-271526-14nfqusv 127 12 compared compare VBN cord-271526-14nfqusv 127 13 to to IN cord-271526-14nfqusv 127 14 the the DT cord-271526-14nfqusv 127 15 protein protein NN cord-271526-14nfqusv 127 16 - - HYPH cord-271526-14nfqusv 127 17 Ps290 Ps290 NNP cord-271526-14nfqusv 127 18 RNA RNA NNP cord-271526-14nfqusv 127 19 complex complex NN cord-271526-14nfqusv 127 20 and and CC cord-271526-14nfqusv 127 21 meier meier NNP cord-271526-14nfqusv 127 22 , , , cord-271526-14nfqusv 127 23 1985 1985 CD cord-271526-14nfqusv 127 24 ) ) -RRB- cord-271526-14nfqusv 127 25 was be VBD cord-271526-14nfqusv 127 26 used use VBN cord-271526-14nfqusv 127 27 to to TO cord-271526-14nfqusv 127 28 analyze analyze VB cord-271526-14nfqusv 127 29 the the DT cord-271526-14nfqusv 127 30 protein protein NN cord-271526-14nfqusv 127 31 - - HYPH cord-271526-14nfqusv 127 32 Ps290 Ps290 NNP cord-271526-14nfqusv 127 33 RNA RNA NNP cord-271526-14nfqusv 127 34 complex complex NN cord-271526-14nfqusv 127 35 and and CC cord-271526-14nfqusv 127 36 the the DT cord-271526-14nfqusv 127 37 monoclonal monoclonal JJ cord-271526-14nfqusv 127 38 b b NN cord-271526-14nfqusv 127 39 - - HYPH cord-271526-14nfqusv 127 40 galactosidase galactosidase NN cord-271526-14nfqusv 127 41 - - HYPH cord-271526-14nfqusv 127 42 specific specific JJ cord-271526-14nfqusv 127 43 antibody antibody NN cord-271526-14nfqusv 127 44 was be VBD cord-271526-14nfqusv 127 45 used use VBN cord-271526-14nfqusv 127 46 as as IN cord-271526-14nfqusv 127 47 a a DT cord-271526-14nfqusv 127 48 control control NN cord-271526-14nfqusv 127 49 . . . cord-271526-14nfqusv 128 1 When when WRB cord-271526-14nfqusv 128 2 N n CD cord-271526-14nfqusv 128 3 - - HYPH cord-271526-14nfqusv 128 4 specific specific JJ cord-271526-14nfqusv 128 5 antiinteraction antiinteraction NN cord-271526-14nfqusv 128 6 we -PRON- PRP cord-271526-14nfqusv 128 7 have have VBP cord-271526-14nfqusv 128 8 first first RB cord-271526-14nfqusv 128 9 used use VBN cord-271526-14nfqusv 128 10 gel gel NN cord-271526-14nfqusv 128 11 mobility mobility NN cord-271526-14nfqusv 128 12 shift shift NN cord-271526-14nfqusv 128 13 assays assay NNS cord-271526-14nfqusv 128 14 body body NN cord-271526-14nfqusv 128 15 5B188.2 5b188.2 CD cord-271526-14nfqusv 128 16 was be VBD cord-271526-14nfqusv 128 17 added add VBN cord-271526-14nfqusv 128 18 to to IN cord-271526-14nfqusv 128 19 the the DT cord-271526-14nfqusv 128 20 complex complex NN cord-271526-14nfqusv 128 21 formed form VBN cord-271526-14nfqusv 128 22 between between IN cord-271526-14nfqusv 128 23 using use VBG cord-271526-14nfqusv 128 24 protein protein NN cord-271526-14nfqusv 128 25 lysates lysate NNS cord-271526-14nfqusv 128 26 from from IN cord-271526-14nfqusv 128 27 both both DT cord-271526-14nfqusv 128 28 MHV MHV NNP cord-271526-14nfqusv 128 29 - - HYPH cord-271526-14nfqusv 128 30 infected infect VBN cord-271526-14nfqusv 128 31 and and CC cord-271526-14nfqusv 128 32 mock mock JJ cord-271526-14nfqusv 128 33 - - HYPH cord-271526-14nfqusv 128 34 Ps290 ps290 NN cord-271526-14nfqusv 128 35 RNA RNA NNP cord-271526-14nfqusv 128 36 and and CC cord-271526-14nfqusv 128 37 proteins protein NNS cord-271526-14nfqusv 128 38 from from IN cord-271526-14nfqusv 128 39 the the DT cord-271526-14nfqusv 128 40 I i NN cord-271526-14nfqusv 128 41 - - HYPH cord-271526-14nfqusv 128 42 lysate lysate NN cord-271526-14nfqusv 128 43 , , , cord-271526-14nfqusv 128 44 a a DT cord-271526-14nfqusv 128 45 second second JJ cord-271526-14nfqusv 128 46 cominfected cominfected JJ cord-271526-14nfqusv 128 47 cells cell NNS cord-271526-14nfqusv 128 48 and and CC cord-271526-14nfqusv 128 49 an an DT cord-271526-14nfqusv 128 50 in in FW cord-271526-14nfqusv 128 51 vitro vitro FW cord-271526-14nfqusv 128 52 transcript transcript NN cord-271526-14nfqusv 128 53 containing contain VBG cord-271526-14nfqusv 128 54 the the DT cord-271526-14nfqusv 128 55 Ps Ps NNP cord-271526-14nfqusv 128 56 plex plex NNP cord-271526-14nfqusv 128 57 , , , cord-271526-14nfqusv 128 58 migrating migrate VBG cord-271526-14nfqusv 128 59 slightly slightly RB cord-271526-14nfqusv 128 60 slower slow JJR cord-271526-14nfqusv 128 61 than than IN cord-271526-14nfqusv 128 62 the the DT cord-271526-14nfqusv 128 63 protein protein NN cord-271526-14nfqusv 128 64 - - HYPH cord-271526-14nfqusv 128 65 Ps290 ps290 NN cord-271526-14nfqusv 128 66 ( ( -LRB- cord-271526-14nfqusv 128 67 Fig Fig NNP cord-271526-14nfqusv 128 68 . . . cord-271526-14nfqusv 128 69 1 1 CD cord-271526-14nfqusv 128 70 ) ) -RRB- cord-271526-14nfqusv 128 71 . . . cord-271526-14nfqusv 129 1 From from IN cord-271526-14nfqusv 129 2 pilot pilot NN cord-271526-14nfqusv 129 3 experiments experiment NNS cord-271526-14nfqusv 129 4 using use VBG cord-271526-14nfqusv 129 5 10 10 CD cord-271526-14nfqusv 129 6 ng ng NN cord-271526-14nfqusv 129 7 of of IN cord-271526-14nfqusv 129 8 labeled label VBN cord-271526-14nfqusv 129 9 RNA RNA NNP cord-271526-14nfqusv 129 10 complex complex NN cord-271526-14nfqusv 129 11 was be VBD cord-271526-14nfqusv 129 12 readily readily RB cord-271526-14nfqusv 129 13 observed observe VBN cord-271526-14nfqusv 129 14 ( ( -LRB- cord-271526-14nfqusv 129 15 Fig Fig NNP cord-271526-14nfqusv 129 16 . . . cord-271526-14nfqusv 129 17 3 3 CD cord-271526-14nfqusv 129 18 , , , cord-271526-14nfqusv 129 19 lane lane NN cord-271526-14nfqusv 129 20 5 5 CD cord-271526-14nfqusv 129 21 ) ) -RRB- cord-271526-14nfqusv 129 22 . . . cord-271526-14nfqusv 130 1 In in IN cord-271526-14nfqusv 130 2 RNA RNA NNP cord-271526-14nfqusv 130 3 we -PRON- PRP cord-271526-14nfqusv 130 4 determined determine VBD cord-271526-14nfqusv 130 5 that that IN cord-271526-14nfqusv 130 6 approximately approximately RB cord-271526-14nfqusv 130 7 4 4 CD cord-271526-14nfqusv 130 8 mg mg NN cord-271526-14nfqusv 130 9 of of IN cord-271526-14nfqusv 130 10 protein protein NN cord-271526-14nfqusv 130 11 contrast contrast NN cord-271526-14nfqusv 130 12 , , , cord-271526-14nfqusv 130 13 addition addition NN cord-271526-14nfqusv 130 14 of of IN cord-271526-14nfqusv 130 15 5B188.2 5b188.2 CD cord-271526-14nfqusv 130 16 to to IN cord-271526-14nfqusv 130 17 the the DT cord-271526-14nfqusv 130 18 complex complex JJ cord-271526-14nfqusv 130 19 formed form VBN cord-271526-14nfqusv 130 20 belysate belysate NNP cord-271526-14nfqusv 130 21 was be VBD cord-271526-14nfqusv 130 22 required require VBN cord-271526-14nfqusv 130 23 to to TO cord-271526-14nfqusv 130 24 observe observe VB cord-271526-14nfqusv 130 25 a a DT cord-271526-14nfqusv 130 26 distinct distinct JJ cord-271526-14nfqusv 130 27 retarded retarded JJ cord-271526-14nfqusv 130 28 band band NN cord-271526-14nfqusv 130 29 tween tween NN cord-271526-14nfqusv 130 30 Ps290 Ps290 NNP cord-271526-14nfqusv 130 31 RNA RNA NNP cord-271526-14nfqusv 130 32 and and CC cord-271526-14nfqusv 130 33 proteins protein NNS cord-271526-14nfqusv 130 34 from from IN cord-271526-14nfqusv 130 35 the the DT cord-271526-14nfqusv 130 36 MI MI NNP cord-271526-14nfqusv 130 37 - - HYPH cord-271526-14nfqusv 130 38 lysate lysate NN cord-271526-14nfqusv 130 39 did do VBD cord-271526-14nfqusv 130 40 ( ( -LRB- cord-271526-14nfqusv 130 41 data datum NNS cord-271526-14nfqusv 130 42 not not RB cord-271526-14nfqusv 130 43 shown show VBN cord-271526-14nfqusv 130 44 ) ) -RRB- cord-271526-14nfqusv 130 45 . . . cord-271526-14nfqusv 131 1 We -PRON- PRP cord-271526-14nfqusv 131 2 therefore therefore RB cord-271526-14nfqusv 131 3 used use VBD cord-271526-14nfqusv 131 4 these these DT cord-271526-14nfqusv 131 5 amounts amount NNS cord-271526-14nfqusv 131 6 as as IN cord-271526-14nfqusv 131 7 not not RB cord-271526-14nfqusv 131 8 result result VB cord-271526-14nfqusv 131 9 in in IN cord-271526-14nfqusv 131 10 a a DT cord-271526-14nfqusv 131 11 supershift supershift NN cord-271526-14nfqusv 131 12 ( ( -LRB- cord-271526-14nfqusv 131 13 Fig Fig NNP cord-271526-14nfqusv 131 14 . . . cord-271526-14nfqusv 131 15 3 3 CD cord-271526-14nfqusv 131 16 , , , cord-271526-14nfqusv 131 17 lane lane NN cord-271526-14nfqusv 131 18 13 13 CD cord-271526-14nfqusv 131 19 ) ) -RRB- cord-271526-14nfqusv 131 20 . . . cord-271526-14nfqusv 132 1 This this DT cord-271526-14nfqusv 132 2 demonstandard demonstandard NN cord-271526-14nfqusv 132 3 in in IN cord-271526-14nfqusv 132 4 all all DT cord-271526-14nfqusv 132 5 binding bind VBG cord-271526-14nfqusv 132 6 experiments experiment NNS cord-271526-14nfqusv 132 7 . . . cord-271526-14nfqusv 133 1 strates strates NNP cord-271526-14nfqusv 133 2 the the DT cord-271526-14nfqusv 133 3 presence presence NN cord-271526-14nfqusv 133 4 of of IN cord-271526-14nfqusv 133 5 the the DT cord-271526-14nfqusv 133 6 MHV MHV NNP cord-271526-14nfqusv 133 7 - - HYPH cord-271526-14nfqusv 133 8 A59 A59 NNP cord-271526-14nfqusv 133 9 N N NNP cord-271526-14nfqusv 133 10 protein protein NN cord-271526-14nfqusv 133 11 in in IN cord-271526-14nfqusv 133 12 the the DT cord-271526-14nfqusv 133 13 An an DT cord-271526-14nfqusv 133 14 interaction interaction NN cord-271526-14nfqusv 133 15 between between IN cord-271526-14nfqusv 133 16 Ps290 Ps290 NNP cord-271526-14nfqusv 133 17 RNA RNA NNP cord-271526-14nfqusv 133 18 and and CC cord-271526-14nfqusv 133 19 proteins protein NNS cord-271526-14nfqusv 133 20 from from IN cord-271526-14nfqusv 133 21 complex complex JJ cord-271526-14nfqusv 133 22 formed form VBN cord-271526-14nfqusv 133 23 between between IN cord-271526-14nfqusv 133 24 Ps290 Ps290 NNP cord-271526-14nfqusv 133 25 RNA RNA NNP cord-271526-14nfqusv 133 26 and and CC cord-271526-14nfqusv 133 27 proteins protein NNS cord-271526-14nfqusv 133 28 from from IN cord-271526-14nfqusv 133 29 infected infected JJ cord-271526-14nfqusv 133 30 cells cell NNS cord-271526-14nfqusv 133 31 ( ( -LRB- cord-271526-14nfqusv 133 32 I i NN cord-271526-14nfqusv 133 33 - - HYPH cord-271526-14nfqusv 133 34 lysate lysate NN cord-271526-14nfqusv 133 35 ) ) -RRB- cord-271526-14nfqusv 133 36 , , , cord-271526-14nfqusv 133 37 as as RB cord-271526-14nfqusv 133 38 well well RB cord-271526-14nfqusv 133 39 as as IN cord-271526-14nfqusv 133 40 from from IN cord-271526-14nfqusv 133 41 mock mock NN cord-271526-14nfqusv 133 42 - - HYPH cord-271526-14nfqusv 133 43 infected infect VBN cord-271526-14nfqusv 133 44 the the DT cord-271526-14nfqusv 133 45 I i NN cord-271526-14nfqusv 133 46 - - HYPH cord-271526-14nfqusv 133 47 lysate lysate NN cord-271526-14nfqusv 133 48 . . . cord-271526-14nfqusv 134 1 cells cell NNS cord-271526-14nfqusv 134 2 ( ( -LRB- cord-271526-14nfqusv 134 3 MI mi NN cord-271526-14nfqusv 134 4 - - HYPH cord-271526-14nfqusv 134 5 lysate lysate NN cord-271526-14nfqusv 134 6 ) ) -RRB- cord-271526-14nfqusv 134 7 was be VBD cord-271526-14nfqusv 134 8 readily readily RB cord-271526-14nfqusv 134 9 observed observe VBN cord-271526-14nfqusv 134 10 ( ( -LRB- cord-271526-14nfqusv 134 11 Fig Fig NNP cord-271526-14nfqusv 134 12 . . NNP cord-271526-14nfqusv 134 13 2 2 CD cord-271526-14nfqusv 134 14 , , , cord-271526-14nfqusv 134 15 lanes lane NNS cord-271526-14nfqusv 134 16 2 2 CD cord-271526-14nfqusv 135 1 The the DT cord-271526-14nfqusv 135 2 b b NN cord-271526-14nfqusv 135 3 - - HYPH cord-271526-14nfqusv 135 4 galactosidase galactosidase NN cord-271526-14nfqusv 135 5 - - HYPH cord-271526-14nfqusv 135 6 specific specific JJ cord-271526-14nfqusv 135 7 antibody antibody NN cord-271526-14nfqusv 135 8 was be VBD cord-271526-14nfqusv 135 9 not not RB cord-271526-14nfqusv 135 10 able able JJ cord-271526-14nfqusv 135 11 to to IN cord-271526-14nfqusv 135 12 and and CC cord-271526-14nfqusv 135 13 9 9 CD cord-271526-14nfqusv 135 14 ) ) -RRB- cord-271526-14nfqusv 135 15 . . . cord-271526-14nfqusv 136 1 However however RB cord-271526-14nfqusv 136 2 , , , cord-271526-14nfqusv 136 3 the the DT cord-271526-14nfqusv 136 4 complex complex NN cord-271526-14nfqusv 136 5 formed form VBN cord-271526-14nfqusv 136 6 between between IN cord-271526-14nfqusv 136 7 Ps290 ps290 NN cord-271526-14nfqusv 136 8 shift shift VB cord-271526-14nfqusv 136 9 the the DT cord-271526-14nfqusv 136 10 complex complex NN cord-271526-14nfqusv 136 11 formed form VBN cord-271526-14nfqusv 136 12 between between IN cord-271526-14nfqusv 136 13 Ps290 Ps290 NNP cord-271526-14nfqusv 136 14 RNA RNA NNP cord-271526-14nfqusv 136 15 and and CC cord-271526-14nfqusv 136 16 pro pro JJ cord-271526-14nfqusv 136 17 - - JJ cord-271526-14nfqusv 136 18 RNA RNA NNP cord-271526-14nfqusv 136 19 and and CC cord-271526-14nfqusv 136 20 proteins protein NNS cord-271526-14nfqusv 136 21 from from IN cord-271526-14nfqusv 136 22 the the DT cord-271526-14nfqusv 136 23 MI MI NNP cord-271526-14nfqusv 136 24 - - HYPH cord-271526-14nfqusv 136 25 lysate lysate NN cord-271526-14nfqusv 137 1 migrated migrate VBN cord-271526-14nfqusv 137 2 slightly slightly RB cord-271526-14nfqusv 137 3 teins tein NNS cord-271526-14nfqusv 137 4 from from IN cord-271526-14nfqusv 137 5 the the DT cord-271526-14nfqusv 137 6 I i NN cord-271526-14nfqusv 137 7 - - HYPH cord-271526-14nfqusv 137 8 lysate lysate NN cord-271526-14nfqusv 137 9 or or CC cord-271526-14nfqusv 137 10 from from IN cord-271526-14nfqusv 137 11 the the DT cord-271526-14nfqusv 137 12 MI MI NNP cord-271526-14nfqusv 137 13 - - HYPH cord-271526-14nfqusv 137 14 lysate lysate NN cord-271526-14nfqusv 137 15 ( ( -LRB- cord-271526-14nfqusv 137 16 Fig fig NN cord-271526-14nfqusv 137 17 . . . cord-271526-14nfqusv 138 1 3 3 LS cord-271526-14nfqusv 138 2 , , , cord-271526-14nfqusv 138 3 lanes lane NNS cord-271526-14nfqusv 138 4 slower slow JJR cord-271526-14nfqusv 138 5 in in IN cord-271526-14nfqusv 138 6 the the DT cord-271526-14nfqusv 138 7 gel gel NN cord-271526-14nfqusv 138 8 and and CC cord-271526-14nfqusv 138 9 appeared appear VBD cord-271526-14nfqusv 138 10 to to TO cord-271526-14nfqusv 138 11 be be VB cord-271526-14nfqusv 138 12 more more RBR cord-271526-14nfqusv 138 13 diffuse diffuse JJ cord-271526-14nfqusv 138 14 , , , cord-271526-14nfqusv 138 15 indi-11 indi-11 CD cord-271526-14nfqusv 138 16 and and CC cord-271526-14nfqusv 138 17 19 19 CD cord-271526-14nfqusv 138 18 ) ) -RRB- cord-271526-14nfqusv 138 19 . . . cord-271526-14nfqusv 139 1 Furthermore furthermore RB cord-271526-14nfqusv 139 2 , , , cord-271526-14nfqusv 139 3 incubation incubation NN cord-271526-14nfqusv 139 4 of of IN cord-271526-14nfqusv 139 5 Ps290 Ps290 NNP cord-271526-14nfqusv 139 6 RNA RNA NNP cord-271526-14nfqusv 139 7 and and CC cord-271526-14nfqusv 139 8 cating cat VBG cord-271526-14nfqusv 139 9 that that IN cord-271526-14nfqusv 139 10 there there EX cord-271526-14nfqusv 139 11 are be VBP cord-271526-14nfqusv 139 12 some some DT cord-271526-14nfqusv 139 13 differences difference NNS cord-271526-14nfqusv 139 14 in in IN cord-271526-14nfqusv 139 15 binding bind VBG cord-271526-14nfqusv 139 16 activity activity NN cord-271526-14nfqusv 139 17 antibody antibody NN cord-271526-14nfqusv 139 18 5B188.2 5b188.2 CD cord-271526-14nfqusv 139 19 or or CC cord-271526-14nfqusv 139 20 b b NN cord-271526-14nfqusv 139 21 - - HYPH cord-271526-14nfqusv 139 22 galactosidase galactosidase NN cord-271526-14nfqusv 139 23 - - HYPH cord-271526-14nfqusv 139 24 specific specific JJ cord-271526-14nfqusv 139 25 antibody antibody NN cord-271526-14nfqusv 139 26 between between IN cord-271526-14nfqusv 139 27 I I NNP cord-271526-14nfqusv 139 28 - - : cord-271526-14nfqusv 139 29 and and CC cord-271526-14nfqusv 139 30 MI MI NNP cord-271526-14nfqusv 139 31 - - HYPH cord-271526-14nfqusv 139 32 lysates lysates NNP cord-271526-14nfqusv 139 33 . . . cord-271526-14nfqusv 140 1 without without IN cord-271526-14nfqusv 140 2 protein protein NN cord-271526-14nfqusv 140 3 lysate lysate NN cord-271526-14nfqusv 140 4 , , , cord-271526-14nfqusv 140 5 did do VBD cord-271526-14nfqusv 140 6 not not RB cord-271526-14nfqusv 140 7 result result VB cord-271526-14nfqusv 140 8 in in IN cord-271526-14nfqusv 140 9 the the DT cord-271526-14nfqusv 140 10 formation formation NN cord-271526-14nfqusv 140 11 of of IN cord-271526-14nfqusv 140 12 In in IN cord-271526-14nfqusv 140 13 order order NN cord-271526-14nfqusv 140 14 to to TO cord-271526-14nfqusv 140 15 determine determine VB cord-271526-14nfqusv 140 16 the the DT cord-271526-14nfqusv 140 17 specificity specificity NN cord-271526-14nfqusv 140 18 of of IN cord-271526-14nfqusv 140 19 the the DT cord-271526-14nfqusv 140 20 interaction interaction NN cord-271526-14nfqusv 140 21 , , , cord-271526-14nfqusv 140 22 competition competition NN cord-271526-14nfqusv 140 23 experiments experiment NNS cord-271526-14nfqusv 140 24 were be VBD cord-271526-14nfqusv 140 25 performed perform VBN cord-271526-14nfqusv 140 26 . . . cord-271526-14nfqusv 141 1 Competition competition NN cord-271526-14nfqusv 141 2 of of IN cord-271526-14nfqusv 141 3 the the DT cord-271526-14nfqusv 141 4 interaction interaction NN cord-271526-14nfqusv 141 5 between between IN cord-271526-14nfqusv 141 6 Ps290 Ps290 NNP cord-271526-14nfqusv 141 7 RNA RNA NNP cord-271526-14nfqusv 141 8 and and CC cord-271526-14nfqusv 141 9 proteins protein NNS cord-271526-14nfqusv 141 10 from from IN cord-271526-14nfqusv 141 11 the the DT cord-271526-14nfqusv 141 12 I i NN cord-271526-14nfqusv 141 13 - - HYPH cord-271526-14nfqusv 141 14 lysate lysate NN cord-271526-14nfqusv 141 15 with with IN cord-271526-14nfqusv 141 16 a a DT cord-271526-14nfqusv 141 17 10-fold 10-fold JJ cord-271526-14nfqusv 141 18 molar molar JJ cord-271526-14nfqusv 141 19 excess excess NN cord-271526-14nfqusv 141 20 of of IN cord-271526-14nfqusv 141 21 nonlabeled nonlabeled NNP cord-271526-14nfqusv 141 22 Ps290 Ps290 NNP cord-271526-14nfqusv 141 23 RNA RNA NNP cord-271526-14nfqusv 141 24 resulted result VBD cord-271526-14nfqusv 141 25 already already RB cord-271526-14nfqusv 141 26 in in IN cord-271526-14nfqusv 141 27 a a DT cord-271526-14nfqusv 141 28 decrease decrease NN cord-271526-14nfqusv 141 29 of of IN cord-271526-14nfqusv 141 30 intensity intensity NN cord-271526-14nfqusv 141 31 of of IN cord-271526-14nfqusv 141 32 the the DT cord-271526-14nfqusv 141 33 retarded retarded JJ cord-271526-14nfqusv 141 34 band band NN cord-271526-14nfqusv 141 35 ( ( -LRB- cord-271526-14nfqusv 141 36 Fig Fig NNP cord-271526-14nfqusv 141 37 . . NNP cord-271526-14nfqusv 141 38 2 2 CD cord-271526-14nfqusv 141 39 , , , cord-271526-14nfqusv 141 40 lane lane NN cord-271526-14nfqusv 141 41 5 5 CD cord-271526-14nfqusv 141 42 ) ) -RRB- cord-271526-14nfqusv 141 43 . . . cord-271526-14nfqusv 142 1 At at IN cord-271526-14nfqusv 142 2 a a DT cord-271526-14nfqusv 142 3 level level NN cord-271526-14nfqusv 142 4 of of IN cord-271526-14nfqusv 142 5 30fold 30fold CD cord-271526-14nfqusv 142 6 molar molar JJ cord-271526-14nfqusv 142 7 excess excess NN cord-271526-14nfqusv 142 8 of of IN cord-271526-14nfqusv 142 9 nonlabeled nonlabeled NNP cord-271526-14nfqusv 142 10 Ps290 Ps290 NNP cord-271526-14nfqusv 142 11 RNA RNA NNP cord-271526-14nfqusv 142 12 the the DT cord-271526-14nfqusv 142 13 retarded retarded JJ cord-271526-14nfqusv 142 14 band band NN cord-271526-14nfqusv 142 15 was be VBD cord-271526-14nfqusv 142 16 no no RB cord-271526-14nfqusv 142 17 longer long RBR cord-271526-14nfqusv 142 18 visible visible JJ cord-271526-14nfqusv 142 19 and and CC cord-271526-14nfqusv 142 20 all all DT cord-271526-14nfqusv 142 21 of of IN cord-271526-14nfqusv 142 22 the the DT cord-271526-14nfqusv 142 23 labeled label VBN cord-271526-14nfqusv 142 24 RNA RNA NNP cord-271526-14nfqusv 142 25 migrated migrate VBD cord-271526-14nfqusv 142 26 at at IN cord-271526-14nfqusv 142 27 the the DT cord-271526-14nfqusv 142 28 position position NN cord-271526-14nfqusv 142 29 of of IN cord-271526-14nfqusv 142 30 the the DT cord-271526-14nfqusv 142 31 unbound unbound JJ cord-271526-14nfqusv 142 32 RNA RNA NNP cord-271526-14nfqusv 142 33 probe probe NN cord-271526-14nfqusv 142 34 ( ( -LRB- cord-271526-14nfqusv 142 35 Fig Fig NNP cord-271526-14nfqusv 142 36 . . . cord-271526-14nfqusv 142 37 _SP cord-271526-14nfqusv 142 38 2 2 CD cord-271526-14nfqusv 142 39 , , , cord-271526-14nfqusv 142 40 lane lane NN cord-271526-14nfqusv 142 41 7 7 CD cord-271526-14nfqusv 142 42 ) ) -RRB- cord-271526-14nfqusv 142 43 . . . cord-271526-14nfqusv 143 1 Competition competition NN cord-271526-14nfqusv 143 2 with with IN cord-271526-14nfqusv 143 3 a a DT cord-271526-14nfqusv 143 4 100-fold 100-fold CD cord-271526-14nfqusv 143 5 molar molar JJ cord-271526-14nfqusv 143 6 excess excess NN cord-271526-14nfqusv 143 7 of of IN cord-271526-14nfqusv 143 8 yeast yeast NN cord-271526-14nfqusv 143 9 tRNA tRNA NNP cord-271526-14nfqusv 143 10 did do VBD cord-271526-14nfqusv 143 11 not not RB cord-271526-14nfqusv 143 12 affect affect VB cord-271526-14nfqusv 143 13 the the DT cord-271526-14nfqusv 143 14 intensity intensity NN cord-271526-14nfqusv 143 15 or or CC cord-271526-14nfqusv 143 16 the the DT cord-271526-14nfqusv 143 17 mobility mobility NN cord-271526-14nfqusv 143 18 of of IN cord-271526-14nfqusv 143 19 the the DT cord-271526-14nfqusv 143 20 retarded retarded JJ cord-271526-14nfqusv 143 21 band band NN cord-271526-14nfqusv 143 22 , , , cord-271526-14nfqusv 143 23 indicating indicate VBG cord-271526-14nfqusv 143 24 that that IN cord-271526-14nfqusv 143 25 the the DT cord-271526-14nfqusv 143 26 observed observed JJ cord-271526-14nfqusv 143 27 interaction interaction NN cord-271526-14nfqusv 143 28 between between IN cord-271526-14nfqusv 143 29 Ps290 Ps290 NNP cord-271526-14nfqusv 143 30 RNA RNA NNP cord-271526-14nfqusv 143 31 and and CC cord-271526-14nfqusv 143 32 proteins protein NNS cord-271526-14nfqusv 143 33 from from IN cord-271526-14nfqusv 143 34 the the DT cord-271526-14nfqusv 143 35 I i NN cord-271526-14nfqusv 143 36 - - HYPH cord-271526-14nfqusv 143 37 lysate lysate NN cord-271526-14nfqusv 143 38 is be VBZ cord-271526-14nfqusv 143 39 specific specific JJ cord-271526-14nfqusv 143 40 for for IN cord-271526-14nfqusv 143 41 the the DT cord-271526-14nfqusv 143 42 Ps290 Ps290 NNP cord-271526-14nfqusv 143 43 RNA RNA NNP cord-271526-14nfqusv 143 44 ( ( -LRB- cord-271526-14nfqusv 143 45 Fig Fig NNP cord-271526-14nfqusv 143 46 . . NNP cord-271526-14nfqusv 143 47 2 2 CD cord-271526-14nfqusv 143 48 , , , cord-271526-14nfqusv 143 49 lane lane NN cord-271526-14nfqusv 143 50 8) 8) NNP cord-271526-14nfqusv 143 51 . . . cord-271526-14nfqusv 144 1 Competition competition NN cord-271526-14nfqusv 144 2 of of IN cord-271526-14nfqusv 144 3 the the DT cord-271526-14nfqusv 144 4 interaction interaction NN cord-271526-14nfqusv 144 5 between between IN cord-271526-14nfqusv 144 6 Ps290 Ps290 NNP cord-271526-14nfqusv 144 7 RNA RNA NNP cord-271526-14nfqusv 144 8 and and CC cord-271526-14nfqusv 144 9 proteins protein NNS cord-271526-14nfqusv 144 10 from from IN cord-271526-14nfqusv 144 11 the the DT cord-271526-14nfqusv 144 12 MI MI NNP cord-271526-14nfqusv 144 13 - - HYPH cord-271526-14nfqusv 144 14 lysate lysate NN cord-271526-14nfqusv 144 15 with with IN cord-271526-14nfqusv 144 16 non non JJ cord-271526-14nfqusv 144 17 - - JJ cord-271526-14nfqusv 144 18 labeled labeled JJ cord-271526-14nfqusv 144 19 Ps290 Ps290 NNP cord-271526-14nfqusv 144 20 RNA RNA NNP cord-271526-14nfqusv 144 21 or or CC cord-271526-14nfqusv 144 22 yeast yeast NN cord-271526-14nfqusv 144 23 tRNA tRNA NNP cord-271526-14nfqusv 144 24 beled beled NNP cord-271526-14nfqusv 144 25 Ps290 Ps290 NNP cord-271526-14nfqusv 144 26 RNA RNA NNP cord-271526-14nfqusv 144 27 competed compete VBD cord-271526-14nfqusv 144 28 entirely entirely RB cord-271526-14nfqusv 144 29 for for IN cord-271526-14nfqusv 144 30 protein protein NN cord-271526-14nfqusv 144 31 binding binding NN cord-271526-14nfqusv 144 32 formed form VBN cord-271526-14nfqusv 144 33 using use VBG cord-271526-14nfqusv 144 34 a a DT cord-271526-14nfqusv 144 35 1-to 1-to CD cord-271526-14nfqusv 144 36 30-fold 30-fold JJ cord-271526-14nfqusv 144 37 molar molar JJ cord-271526-14nfqusv 144 38 excess excess NN cord-271526-14nfqusv 144 39 of of IN cord-271526-14nfqusv 144 40 unlabeled unlabeled JJ cord-271526-14nfqusv 144 41 Ps290 Ps290 NNP cord-271526-14nfqusv 144 42 RNA RNA NNP cord-271526-14nfqusv 144 43 or or CC cord-271526-14nfqusv 144 44 ( ( -LRB- cord-271526-14nfqusv 144 45 Fig Fig NNP cord-271526-14nfqusv 144 46 . . NNP cord-271526-14nfqusv 144 47 2 2 CD cord-271526-14nfqusv 144 48 , , , cord-271526-14nfqusv 144 49 lane lane NN cord-271526-14nfqusv 144 50 14 14 CD cord-271526-14nfqusv 144 51 ) ) -RRB- cord-271526-14nfqusv 144 52 , , , cord-271526-14nfqusv 144 53 whereas whereas IN cord-271526-14nfqusv 144 54 a a DT cord-271526-14nfqusv 144 55 100-fold 100-fold CD cord-271526-14nfqusv 144 56 molar molar JJ cord-271526-14nfqusv 144 57 excess excess NN cord-271526-14nfqusv 144 58 of of IN cord-271526-14nfqusv 144 59 a a DT cord-271526-14nfqusv 144 60 1-to 1-to CD cord-271526-14nfqusv 144 61 100-fold 100-fold CD cord-271526-14nfqusv 144 62 molar molar JJ cord-271526-14nfqusv 144 63 excess excess NN cord-271526-14nfqusv 144 64 of of IN cord-271526-14nfqusv 144 65 yeast yeast NN cord-271526-14nfqusv 144 66 tRNA tRNA NNP cord-271526-14nfqusv 144 67 . . . cord-271526-14nfqusv 145 1 The the DT cord-271526-14nfqusv 145 2 positions position NNS cord-271526-14nfqusv 145 3 of of IN cord-271526-14nfqusv 145 4 the the DT cord-271526-14nfqusv 145 5 unbound unbound JJ cord-271526-14nfqusv 145 6 RNA RNA NNP cord-271526-14nfqusv 145 7 ( ( -LRB- cord-271526-14nfqusv 145 8 probe probe NN cord-271526-14nfqusv 145 9 ) ) -RRB- cord-271526-14nfqusv 145 10 and and CC cord-271526-14nfqusv 145 11 complexed complexed JJ cord-271526-14nfqusv 145 12 RNA RNA NNP cord-271526-14nfqusv 145 13 ( ( -LRB- cord-271526-14nfqusv 145 14 complex complex NNP cord-271526-14nfqusv 145 15 ) ) -RRB- cord-271526-14nfqusv 145 16 are be VBP cord-271526-14nfqusv 145 17 indicated indicate VBN cord-271526-14nfqusv 145 18 . . . cord-271526-14nfqusv 146 1 yeast yeast NNP cord-271526-14nfqusv 146 2 tRNA tRNA NNP cord-271526-14nfqusv 146 3 had have VBD cord-271526-14nfqusv 146 4 no no DT cord-271526-14nfqusv 146 5 effect effect NN cord-271526-14nfqusv 146 6 on on IN cord-271526-14nfqusv 146 7 the the DT cord-271526-14nfqusv 146 8 interaction interaction NN cord-271526-14nfqusv 146 9 ( ( -LRB- cord-271526-14nfqusv 146 10 Fig Fig NNP cord-271526-14nfqusv 146 11 . . NNP cord-271526-14nfqusv 146 12 2 2 CD cord-271526-14nfqusv 146 13 , , , cord-271526-14nfqusv 146 14 lane lane NN cord-271526-14nfqusv 146 15 tor tor NNP cord-271526-14nfqusv 146 16 RNA RNA NNP cord-271526-14nfqusv 146 17 . . . cord-271526-14nfqusv 147 1 Cross cross NN cord-271526-14nfqusv 147 2 - - VBN cord-271526-14nfqusv 147 3 linked link VBN cord-271526-14nfqusv 147 4 and and CC cord-271526-14nfqusv 147 5 RNase rnase NN cord-271526-14nfqusv 147 6 treated treat VBN cord-271526-14nfqusv 147 7 samples sample NNS cord-271526-14nfqusv 147 8 were be VBD cord-271526-14nfqusv 147 9 immunoprecipitated immunoprecipitate VBN cord-271526-14nfqusv 147 10 with with IN cord-271526-14nfqusv 147 11 the the DT cord-271526-14nfqusv 147 12 monoclonal monoclonal JJ cord-271526-14nfqusv 147 13 N n CD cord-271526-14nfqusv 147 14 - - HYPH cord-271526-14nfqusv 147 15 specific specific JJ cord-271526-14nfqusv 147 16 antibody antibody NN cord-271526-14nfqusv 147 17 5B188.2 5b188.2 CD cord-271526-14nfqusv 147 18 or or CC cord-271526-14nfqusv 147 19 the the DT cord-271526-14nfqusv 147 20 rabbit rabbit NN cord-271526-14nfqusv 147 21 polyclonal polyclonal JJ cord-271526-14nfqusv 147 22 MHV MHV NNP cord-271526-14nfqusv 147 23 - - HYPH cord-271526-14nfqusv 147 24 A59 A59 NNP cord-271526-14nfqusv 147 25 antiserum antiserum NN cord-271526-14nfqusv 147 26 k134 k134 NN cord-271526-14nfqusv 147 27 as as IN cord-271526-14nfqusv 147 28 indicated indicate VBN cord-271526-14nfqusv 147 29 in in IN cord-271526-14nfqusv 147 30 the the DT cord-271526-14nfqusv 147 31 figure figure NN cord-271526-14nfqusv 147 32 legends legend NNS cord-271526-14nfqusv 147 33 . . . cord-271526-14nfqusv 148 1 An an DT cord-271526-14nfqusv 148 2 interaction interaction NN cord-271526-14nfqusv 148 3 between between IN cord-271526-14nfqusv 148 4 the the DT cord-271526-14nfqusv 148 5 N N NNP cord-271526-14nfqusv 148 6 protein protein NN cord-271526-14nfqusv 148 7 and and CC cord-271526-14nfqusv 148 8 Ps180 Ps180 NNP cord-271526-14nfqusv 148 9 RNA RNA NNP cord-271526-14nfqusv 148 10 was be VBD cord-271526-14nfqusv 148 11 readily readily RB cord-271526-14nfqusv 148 12 observed observe VBN cord-271526-14nfqusv 148 13 ( ( -LRB- cord-271526-14nfqusv 148 14 Fig Fig NNP cord-271526-14nfqusv 148 15 . . NNP cord-271526-14nfqusv 148 16 4 4 CD cord-271526-14nfqusv 148 17 , , , cord-271526-14nfqusv 148 18 lane lane NN cord-271526-14nfqusv 148 19 1 1 CD cord-271526-14nfqusv 148 20 ) ) -RRB- cord-271526-14nfqusv 148 21 , , , cord-271526-14nfqusv 148 22 but but CC cord-271526-14nfqusv 148 23 no no DT cord-271526-14nfqusv 148 24 interaction interaction NN cord-271526-14nfqusv 148 25 was be VBD cord-271526-14nfqusv 148 26 observed observe VBN cord-271526-14nfqusv 148 27 between between IN cord-271526-14nfqusv 148 28 the the DT cord-271526-14nfqusv 148 29 N n NN cord-271526-14nfqusv 148 30 - - HYPH cord-271526-14nfqusv 148 31 protein protein NN cord-271526-14nfqusv 148 32 and and CC cord-271526-14nfqusv 148 33 PsDHP PsDHP NNP cord-271526-14nfqusv 148 34 RNA RNA NNP cord-271526-14nfqusv 148 35 ( ( -LRB- cord-271526-14nfqusv 148 36 Fig Fig NNP cord-271526-14nfqusv 148 37 . . NNP cord-271526-14nfqusv 148 38 4 4 CD cord-271526-14nfqusv 148 39 , , , cord-271526-14nfqusv 148 40 lane lane NN cord-271526-14nfqusv 148 41 2 2 CD cord-271526-14nfqusv 148 42 ) ) -RRB- cord-271526-14nfqusv 148 43 . . . cord-271526-14nfqusv 149 1 Complexes complex NNS cord-271526-14nfqusv 149 2 formed form VBN cord-271526-14nfqusv 149 3 between between IN cord-271526-14nfqusv 149 4 proteins protein NNS cord-271526-14nfqusv 149 5 from from IN cord-271526-14nfqusv 149 6 the the DT cord-271526-14nfqusv 149 7 MI MI NNP cord-271526-14nfqusv 149 8 - - HYPH cord-271526-14nfqusv 149 9 lysate lysate NN cord-271526-14nfqusv 149 10 and and CC cord-271526-14nfqusv 149 11 Ps180 Ps180 NNP cord-271526-14nfqusv 149 12 RNA RNA NNP cord-271526-14nfqusv 149 13 or or CC cord-271526-14nfqusv 149 14 PsDHP PsDHP NNP cord-271526-14nfqusv 149 15 RNA RNA NNP cord-271526-14nfqusv 149 16 could could MD cord-271526-14nfqusv 149 17 not not RB cord-271526-14nfqusv 149 18 be be VB cord-271526-14nfqusv 149 19 immunoprecipitated immunoprecipitate VBN cord-271526-14nfqusv 149 20 with with IN cord-271526-14nfqusv 149 21 the the DT cord-271526-14nfqusv 149 22 N n CD cord-271526-14nfqusv 149 23 - - HYPH cord-271526-14nfqusv 149 24 specific specific JJ cord-271526-14nfqusv 149 25 antibody antibody NN cord-271526-14nfqusv 149 26 ( ( -LRB- cord-271526-14nfqusv 149 27 Fig Fig NNP cord-271526-14nfqusv 149 28 . . . cord-271526-14nfqusv 149 29 _SP cord-271526-14nfqusv 150 1 4 4 LS cord-271526-14nfqusv 150 2 , , , cord-271526-14nfqusv 150 3 lanes lane NNS cord-271526-14nfqusv 150 4 3 3 CD cord-271526-14nfqusv 150 5 and and CC cord-271526-14nfqusv 150 6 4 4 CD cord-271526-14nfqusv 150 7 ) ) -RRB- cord-271526-14nfqusv 150 8 . . . cord-271526-14nfqusv 151 1 When when WRB cord-271526-14nfqusv 151 2 the the DT cord-271526-14nfqusv 151 3 Ps180 ps180 NN cord-271526-14nfqusv 151 4 and and CC cord-271526-14nfqusv 151 5 PsDHP psdhp JJ cord-271526-14nfqusv 151 6 RNAs rna NNS cord-271526-14nfqusv 151 7 were be VBD cord-271526-14nfqusv 151 8 used use VBN cord-271526-14nfqusv 151 9 in in IN cord-271526-14nfqusv 151 10 a a DT cord-271526-14nfqusv 151 11 competitive competitive JJ cord-271526-14nfqusv 151 12 gelretardation gelretardation NN cord-271526-14nfqusv 151 13 experiment experiment NN cord-271526-14nfqusv 151 14 with with IN cord-271526-14nfqusv 151 15 radiolabeled radiolabeled JJ cord-271526-14nfqusv 151 16 Ps290 Ps290 NNP cord-271526-14nfqusv 151 17 and and CC cord-271526-14nfqusv 151 18 the the DT cord-271526-14nfqusv 151 19 I i NN cord-271526-14nfqusv 151 20 - - HYPH cord-271526-14nfqusv 151 21 lysate lysate NN cord-271526-14nfqusv 151 22 , , , cord-271526-14nfqusv 151 23 complete complete JJ cord-271526-14nfqusv 151 24 competition competition NN cord-271526-14nfqusv 151 25 was be VBD cord-271526-14nfqusv 151 26 observed observe VBN cord-271526-14nfqusv 151 27 with with IN cord-271526-14nfqusv 151 28 the the DT cord-271526-14nfqusv 151 29 Ps180 Ps180 NNP cord-271526-14nfqusv 151 30 RNA RNA NNP cord-271526-14nfqusv 151 31 , , , cord-271526-14nfqusv 151 32 whereas whereas IN cord-271526-14nfqusv 151 33 no no DT cord-271526-14nfqusv 151 34 immunoprecipitation immunoprecipitation NN cord-271526-14nfqusv 151 35 and and CC cord-271526-14nfqusv 151 36 that that IN cord-271526-14nfqusv 151 37 this this DT cord-271526-14nfqusv 151 38 interaction interaction NN cord-271526-14nfqusv 151 39 is be VBZ cord-271526-14nfqusv 151 40 dependent dependent JJ cord-271526-14nfqusv 151 41 on on IN cord-271526-14nfqusv 151 42 the the DT cord-271526-14nfqusv 151 43 presence presence NN cord-271526-14nfqusv 151 44 of of IN cord-271526-14nfqusv 151 45 the the DT cord-271526-14nfqusv 151 46 69-nt 69-nt CD cord-271526-14nfqusv 151 47 Ps Ps NNP cord-271526-14nfqusv 151 48 hairpin hairpin NN cord-271526-14nfqusv 151 49 . . . cord-271526-14nfqusv 152 1 To to TO cord-271526-14nfqusv 152 2 determine determine VB cord-271526-14nfqusv 152 3 the the DT cord-271526-14nfqusv 152 4 specificity specificity NN cord-271526-14nfqusv 152 5 of of IN cord-271526-14nfqusv 152 6 the the DT cord-271526-14nfqusv 152 7 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 152 8 pro pro JJ cord-271526-14nfqusv 152 9 - - JJ cord-271526-14nfqusv 152 10 RNA rna JJ cord-271526-14nfqusv 152 11 - - HYPH cord-271526-14nfqusv 152 12 protein protein NN cord-271526-14nfqusv 152 13 complexes complex NNS cord-271526-14nfqusv 152 14 ( ( -LRB- cord-271526-14nfqusv 152 15 Fig Fig NNP cord-271526-14nfqusv 152 16 . . . cord-271526-14nfqusv 152 17 3 3 CD cord-271526-14nfqusv 152 18 , , , cord-271526-14nfqusv 152 19 lanes lane NNS cord-271526-14nfqusv 152 20 8 8 CD cord-271526-14nfqusv 152 21 - - SYM cord-271526-14nfqusv 152 22 10 10 CD cord-271526-14nfqusv 152 23 and and CC cord-271526-14nfqusv 152 24 12 12 CD cord-271526-14nfqusv 152 25 ) ) -RRB- cord-271526-14nfqusv 152 26 , , , cord-271526-14nfqusv 152 27 tein tein NNP cord-271526-14nfqusv 152 28 - - HYPH cord-271526-14nfqusv 152 29 Ps180 Ps180 NNP cord-271526-14nfqusv 152 30 RNA RNA NNP cord-271526-14nfqusv 152 31 interaction interaction NN cord-271526-14nfqusv 152 32 in in IN cord-271526-14nfqusv 152 33 UV UV NNP cord-271526-14nfqusv 152 34 cross cross JJ cord-271526-14nfqusv 152 35 - - JJ cord-271526-14nfqusv 152 36 linking link VBG cord-271526-14nfqusv 152 37 assays assay NNS cord-271526-14nfqusv 152 38 , , , cord-271526-14nfqusv 152 39 clearly clearly RB cord-271526-14nfqusv 152 40 indicating indicate VBG cord-271526-14nfqusv 152 41 that that IN cord-271526-14nfqusv 152 42 the the DT cord-271526-14nfqusv 152 43 observed observed JJ cord-271526-14nfqusv 152 44 supershift supershift NN cord-271526-14nfqusv 152 45 was be VBD cord-271526-14nfqusv 152 46 not not RB cord-271526-14nfqusv 152 47 competition competition NN cord-271526-14nfqusv 152 48 experiments experiment NNS cord-271526-14nfqusv 152 49 were be VBD cord-271526-14nfqusv 152 50 performed perform VBN cord-271526-14nfqusv 152 51 . . . cord-271526-14nfqusv 153 1 Addition addition NN cord-271526-14nfqusv 153 2 of of IN cord-271526-14nfqusv 153 3 a a DT cord-271526-14nfqusv 153 4 the the DT cord-271526-14nfqusv 153 5 result result NN cord-271526-14nfqusv 153 6 of of IN cord-271526-14nfqusv 153 7 an an DT cord-271526-14nfqusv 153 8 interaction interaction NN cord-271526-14nfqusv 153 9 between between IN cord-271526-14nfqusv 153 10 the the DT cord-271526-14nfqusv 153 11 RNA RNA NNP cord-271526-14nfqusv 153 12 probe probe NN cord-271526-14nfqusv 153 13 and and CC cord-271526-14nfqusv 153 14 100-fold 100-fold CD cord-271526-14nfqusv 153 15 molar molar JJ cord-271526-14nfqusv 153 16 excess excess NN cord-271526-14nfqusv 153 17 of of IN cord-271526-14nfqusv 153 18 nonlabeled nonlabeled NNP cord-271526-14nfqusv 153 19 Ps180 Ps180 NNP cord-271526-14nfqusv 153 20 RNA RNA NNP cord-271526-14nfqusv 153 21 resulted result VBD cord-271526-14nfqusv 153 22 the the DT cord-271526-14nfqusv 153 23 N n CD cord-271526-14nfqusv 153 24 - - HYPH cord-271526-14nfqusv 153 25 specific specific JJ cord-271526-14nfqusv 153 26 antibody antibody NN cord-271526-14nfqusv 153 27 . . . cord-271526-14nfqusv 154 1 in in IN cord-271526-14nfqusv 154 2 the the DT cord-271526-14nfqusv 154 3 complete complete JJ cord-271526-14nfqusv 154 4 inhibition inhibition NN cord-271526-14nfqusv 154 5 of of IN cord-271526-14nfqusv 154 6 N n CD cord-271526-14nfqusv 154 7 protein protein NN cord-271526-14nfqusv 154 8 binding binding NN cord-271526-14nfqusv 154 9 ( ( -LRB- cord-271526-14nfqusv 154 10 Fig Fig NNP cord-271526-14nfqusv 154 11 . . NNP cord-271526-14nfqusv 154 12 5 5 CD cord-271526-14nfqusv 154 13 , , , cord-271526-14nfqusv 154 14 Addition addition NN cord-271526-14nfqusv 154 15 of of IN cord-271526-14nfqusv 154 16 a a DT cord-271526-14nfqusv 154 17 100-fold 100-fold CD cord-271526-14nfqusv 154 18 molar molar JJ cord-271526-14nfqusv 154 19 excess excess NN cord-271526-14nfqusv 154 20 of of IN cord-271526-14nfqusv 154 21 nonlabeled nonlabeled JJ cord-271526-14nfqusv 154 22 lane lane NNP cord-271526-14nfqusv 154 23 2 2 CD cord-271526-14nfqusv 154 24 ) ) -RRB- cord-271526-14nfqusv 154 25 , , , cord-271526-14nfqusv 154 26 whereas whereas RB cord-271526-14nfqusv 154 27 , , , cord-271526-14nfqusv 154 28 a a DT cord-271526-14nfqusv 154 29 100-fold 100-fold CD cord-271526-14nfqusv 154 30 molar molar JJ cord-271526-14nfqusv 154 31 excess excess NN cord-271526-14nfqusv 154 32 of of IN cord-271526-14nfqusv 154 33 tRNA tRNA NNP cord-271526-14nfqusv 154 34 had have VBD cord-271526-14nfqusv 154 35 Ps290 ps290 NN cord-271526-14nfqusv 154 36 competitor competitor NN cord-271526-14nfqusv 154 37 RNA RNA NNP cord-271526-14nfqusv 154 38 resulted result VBD cord-271526-14nfqusv 154 39 in in IN cord-271526-14nfqusv 154 40 the the DT cord-271526-14nfqusv 154 41 complete complete JJ cord-271526-14nfqusv 154 42 inhibition inhibition NN cord-271526-14nfqusv 154 43 no no DT cord-271526-14nfqusv 154 44 effect effect NN cord-271526-14nfqusv 154 45 on on IN cord-271526-14nfqusv 154 46 the the DT cord-271526-14nfqusv 154 47 interaction interaction NN cord-271526-14nfqusv 154 48 between between IN cord-271526-14nfqusv 154 49 the the DT cord-271526-14nfqusv 154 50 N N NNP cord-271526-14nfqusv 154 51 protein protein NN cord-271526-14nfqusv 154 52 and and CC cord-271526-14nfqusv 154 53 of of IN cord-271526-14nfqusv 154 54 protein protein NN cord-271526-14nfqusv 154 55 binding bind VBG cord-271526-14nfqusv 154 56 to to IN cord-271526-14nfqusv 154 57 the the DT cord-271526-14nfqusv 154 58 RNA RNA NNP cord-271526-14nfqusv 154 59 probe probe NN cord-271526-14nfqusv 154 60 ( ( -LRB- cord-271526-14nfqusv 154 61 Fig Fig NNP cord-271526-14nfqusv 154 62 . . . cord-271526-14nfqusv 154 63 3 3 CD cord-271526-14nfqusv 154 64 , , , cord-271526-14nfqusv 154 65 lane lane NN cord-271526-14nfqusv 154 66 6 6 CD cord-271526-14nfqusv 154 67 ) ) -RRB- cord-271526-14nfqusv 154 68 . . . cord-271526-14nfqusv 155 1 In in IN cord-271526-14nfqusv 155 2 Ps180 Ps180 NNP cord-271526-14nfqusv 155 3 RNA RNA NNP cord-271526-14nfqusv 155 4 ( ( -LRB- cord-271526-14nfqusv 155 5 Fig Fig NNP cord-271526-14nfqusv 155 6 . . NNP cord-271526-14nfqusv 155 7 5 5 CD cord-271526-14nfqusv 155 8 , , , cord-271526-14nfqusv 155 9 lane lane NN cord-271526-14nfqusv 155 10 3 3 CD cord-271526-14nfqusv 155 11 ) ) -RRB- cord-271526-14nfqusv 155 12 . . . cord-271526-14nfqusv 156 1 This this DT cord-271526-14nfqusv 156 2 clearly clearly RB cord-271526-14nfqusv 156 3 demonstrates demonstrate VBZ cord-271526-14nfqusv 156 4 the the DT cord-271526-14nfqusv 156 5 contrast contrast NN cord-271526-14nfqusv 156 6 , , , cord-271526-14nfqusv 156 7 a a DT cord-271526-14nfqusv 156 8 100-fold 100-fold CD cord-271526-14nfqusv 156 9 molar molar JJ cord-271526-14nfqusv 156 10 excess excess NN cord-271526-14nfqusv 156 11 of of IN cord-271526-14nfqusv 156 12 tRNA trna NN cord-271526-14nfqusv 156 13 did do VBD cord-271526-14nfqusv 156 14 not not RB cord-271526-14nfqusv 156 15 affect affect VB cord-271526-14nfqusv 156 16 specificity specificity NN cord-271526-14nfqusv 156 17 of of IN cord-271526-14nfqusv 156 18 the the DT cord-271526-14nfqusv 156 19 interaction interaction NN cord-271526-14nfqusv 156 20 between between IN cord-271526-14nfqusv 156 21 the the DT cord-271526-14nfqusv 156 22 N N NNP cord-271526-14nfqusv 156 23 protein protein NN cord-271526-14nfqusv 156 24 and and CC cord-271526-14nfqusv 156 25 the the DT cord-271526-14nfqusv 156 26 formation formation NN cord-271526-14nfqusv 156 27 of of IN cord-271526-14nfqusv 156 28 RNA rna NN cord-271526-14nfqusv 156 29 - - HYPH cord-271526-14nfqusv 156 30 protein protein NNP cord-271526-14nfqusv 156 31 and and CC cord-271526-14nfqusv 156 32 RNA rna NN cord-271526-14nfqusv 156 33 - - HYPH cord-271526-14nfqusv 156 34 protein protein NN cord-271526-14nfqusv 156 35 - - HYPH cord-271526-14nfqusv 156 36 anti anti NN cord-271526-14nfqusv 156 37 - - JJ cord-271526-14nfqusv 156 38 Ps180 ps180 JJ cord-271526-14nfqusv 156 39 RNA RNA NNP cord-271526-14nfqusv 156 40 . . . cord-271526-14nfqusv 157 1 body body NN cord-271526-14nfqusv 157 2 complexes complex NNS cord-271526-14nfqusv 157 3 ( ( -LRB- cord-271526-14nfqusv 157 4 Fig Fig NNP cord-271526-14nfqusv 157 5 . . . cord-271526-14nfqusv 157 6 3 3 CD cord-271526-14nfqusv 157 7 , , , cord-271526-14nfqusv 157 8 lane lane NN cord-271526-14nfqusv 157 9 7 7 CD cord-271526-14nfqusv 157 10 ) ) -RRB- cord-271526-14nfqusv 157 11 , , , cord-271526-14nfqusv 157 12 which which WDT cord-271526-14nfqusv 157 13 demonstrates demonstrate VBZ cord-271526-14nfqusv 157 14 the the DT cord-271526-14nfqusv 157 15 specificity specificity NN cord-271526-14nfqusv 157 16 of of IN cord-271526-14nfqusv 157 17 the the DT cord-271526-14nfqusv 157 18 interaction interaction NN cord-271526-14nfqusv 157 19 between between IN cord-271526-14nfqusv 157 20 the the DT cord-271526-14nfqusv 157 21 N N NNP cord-271526-14nfqusv 157 22 protein protein NN cord-271526-14nfqusv 157 23 and and CC cord-271526-14nfqusv 157 24 Ps290 Ps290 NNP cord-271526-14nfqusv 157 25 RNA RNA NNP cord-271526-14nfqusv 157 26 . . . cord-271526-14nfqusv 158 1 Nucleocapsid Nucleocapsid NNP cord-271526-14nfqusv 158 2 protein protein NN cord-271526-14nfqusv 158 3 from from IN cord-271526-14nfqusv 158 4 purified purify VBN cord-271526-14nfqusv 158 5 viruses virus NNS cord-271526-14nfqusv 158 6 and and CC cord-271526-14nfqusv 158 7 recombinant recombinant JJ cord-271526-14nfqusv 158 8 expressed express VBD cord-271526-14nfqusv 158 9 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 158 10 protein protein NN cord-271526-14nfqusv 158 11 interact interact VB cord-271526-14nfqusv 158 12 specifically specifically RB cord-271526-14nfqusv 158 13 with with IN cord-271526-14nfqusv 158 14 Ps180 Ps180 NNP cord-271526-14nfqusv 158 15 RNA RNA NNP cord-271526-14nfqusv 158 16 UV UV NNP cord-271526-14nfqusv 158 17 cross cross NN cord-271526-14nfqusv 158 18 - - JJ cord-271526-14nfqusv 158 19 linking linking NN cord-271526-14nfqusv 158 20 demonstrates demonstrate VBZ cord-271526-14nfqusv 158 21 specific specific JJ cord-271526-14nfqusv 158 22 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 158 23 protein protein NN cord-271526-14nfqusv 158 24 Ps180-RNA Ps180-RNA NNP cord-271526-14nfqusv 158 25 interaction interaction NN cord-271526-14nfqusv 158 26 During during IN cord-271526-14nfqusv 158 27 RNA RNA NNP cord-271526-14nfqusv 158 28 encapsidation encapsidation NN cord-271526-14nfqusv 158 29 or or CC cord-271526-14nfqusv 158 30 particle particle NN cord-271526-14nfqusv 158 31 formation formation NN cord-271526-14nfqusv 158 32 , , , cord-271526-14nfqusv 158 33 the the DT cord-271526-14nfqusv 158 34 N n CD cord-271526-14nfqusv 158 35 protein protein NN cord-271526-14nfqusv 158 36 might may MD cord-271526-14nfqusv 158 37 undergo undergo VB cord-271526-14nfqusv 158 38 structural structural JJ cord-271526-14nfqusv 158 39 changes change NNS cord-271526-14nfqusv 158 40 or or CC cord-271526-14nfqusv 158 41 other other JJ cord-271526-14nfqusv 158 42 modifi- modifi- NN cord-271526-14nfqusv 159 1 Another another DT cord-271526-14nfqusv 159 2 assay assay NN cord-271526-14nfqusv 159 3 for for IN cord-271526-14nfqusv 159 4 studying study VBG cord-271526-14nfqusv 159 5 the the DT cord-271526-14nfqusv 159 6 interaction interaction NN cord-271526-14nfqusv 159 7 between between IN cord-271526-14nfqusv 159 8 the the DT cord-271526-14nfqusv 159 9 cations cation NNS cord-271526-14nfqusv 159 10 . . . cord-271526-14nfqusv 160 1 It -PRON- PRP cord-271526-14nfqusv 160 2 would would MD cord-271526-14nfqusv 160 3 therefore therefore RB cord-271526-14nfqusv 160 4 be be VB cord-271526-14nfqusv 160 5 interesting interesting JJ cord-271526-14nfqusv 160 6 to to TO cord-271526-14nfqusv 160 7 see see VB cord-271526-14nfqusv 160 8 if if IN cord-271526-14nfqusv 160 9 the the DT cord-271526-14nfqusv 160 10 N N NNP cord-271526-14nfqusv 160 11 N N NNP cord-271526-14nfqusv 160 12 protein protein NN cord-271526-14nfqusv 160 13 and and CC cord-271526-14nfqusv 160 14 Ps Ps NNP cord-271526-14nfqusv 160 15 containing contain VBG cord-271526-14nfqusv 160 16 RNAs rna NNS cord-271526-14nfqusv 160 17 is be VBZ cord-271526-14nfqusv 160 18 UV UV NNP cord-271526-14nfqusv 160 19 cross cross NN cord-271526-14nfqusv 160 20 - - JJ cord-271526-14nfqusv 160 21 linking linking NN cord-271526-14nfqusv 160 22 . . . cord-271526-14nfqusv 161 1 protein protein NN cord-271526-14nfqusv 161 2 incorporated incorporate VBN cord-271526-14nfqusv 161 3 in in IN cord-271526-14nfqusv 161 4 virus virus NN cord-271526-14nfqusv 161 5 particles particle NNS cord-271526-14nfqusv 161 6 is be VBZ cord-271526-14nfqusv 161 7 still still RB cord-271526-14nfqusv 161 8 able able JJ cord-271526-14nfqusv 161 9 to to TO cord-271526-14nfqusv 161 10 inter inter VB cord-271526-14nfqusv 161 11 - - : cord-271526-14nfqusv 161 12 To to TO cord-271526-14nfqusv 161 13 exclude exclude VB cord-271526-14nfqusv 161 14 the the DT cord-271526-14nfqusv 161 15 possibility possibility NN cord-271526-14nfqusv 161 16 that that IN cord-271526-14nfqusv 161 17 the the DT cord-271526-14nfqusv 161 18 non non JJ cord-271526-14nfqusv 161 19 - - JJ cord-271526-14nfqusv 161 20 MHV mhv NN cord-271526-14nfqusv 161 21 - - HYPH cord-271526-14nfqusv 161 22 specific specific JJ cord-271526-14nfqusv 161 23 sequences sequence NNS cord-271526-14nfqusv 161 24 present present JJ cord-271526-14nfqusv 161 25 in in IN cord-271526-14nfqusv 161 26 Ps290 Ps290 NNP cord-271526-14nfqusv 161 27 RNA RNA NNP cord-271526-14nfqusv 161 28 are be VBP cord-271526-14nfqusv 161 29 involved involve VBN cord-271526-14nfqusv 161 30 in in IN cord-271526-14nfqusv 161 31 the the DT cord-271526-14nfqusv 161 32 interaction interaction NN cord-271526-14nfqusv 161 33 between between IN cord-271526-14nfqusv 161 34 the the DT cord-271526-14nfqusv 161 35 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 161 36 - - HYPH cord-271526-14nfqusv 161 37 protein protein NN cord-271526-14nfqusv 161 38 and and CC cord-271526-14nfqusv 161 39 Ps290 Ps290 NNP cord-271526-14nfqusv 161 40 RNA RNA NNP cord-271526-14nfqusv 161 41 , , , cord-271526-14nfqusv 161 42 an an DT cord-271526-14nfqusv 161 43 RNA RNA NNP cord-271526-14nfqusv 161 44 probe probe NN cord-271526-14nfqusv 161 45 ( ( -LRB- cord-271526-14nfqusv 161 46 Ps180 ps180 NN cord-271526-14nfqusv 161 47 ) ) -RRB- cord-271526-14nfqusv 161 48 containing contain VBG cord-271526-14nfqusv 161 49 only only RB cord-271526-14nfqusv 161 50 MHV mhv NN cord-271526-14nfqusv 161 51 - - HYPH cord-271526-14nfqusv 161 52 specific specific JJ cord-271526-14nfqusv 161 53 sequences sequence NNS cord-271526-14nfqusv 161 54 was be VBD cord-271526-14nfqusv 161 55 constructed construct VBN cord-271526-14nfqusv 161 56 . . . cord-271526-14nfqusv 162 1 Furthermore furthermore RB cord-271526-14nfqusv 162 2 , , , cord-271526-14nfqusv 162 3 in in IN cord-271526-14nfqusv 162 4 order order NN cord-271526-14nfqusv 162 5 to to TO cord-271526-14nfqusv 162 6 investigate investigate VB cord-271526-14nfqusv 162 7 whether whether IN cord-271526-14nfqusv 162 8 the the DT cord-271526-14nfqusv 162 9 69-nt 69-nt CD cord-271526-14nfqusv 162 10 hairpin hairpin NN cord-271526-14nfqusv 162 11 of of IN cord-271526-14nfqusv 162 12 Ps180 ps180 NN cord-271526-14nfqusv 162 13 ( ( -LRB- cord-271526-14nfqusv 162 14 and and CC cord-271526-14nfqusv 162 15 Ps290 ps290 NN cord-271526-14nfqusv 162 16 ) ) -RRB- cord-271526-14nfqusv 163 1 RNA RNA NNP cord-271526-14nfqusv 163 2 is be VBZ cord-271526-14nfqusv 163 3 responsible responsible JJ cord-271526-14nfqusv 163 4 for for IN cord-271526-14nfqusv 163 5 specific specific JJ cord-271526-14nfqusv 163 6 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 163 7 protein protein NN cord-271526-14nfqusv 163 8 binding binding NN cord-271526-14nfqusv 163 9 , , , cord-271526-14nfqusv 163 10 PsDHP PsDHP NNP cord-271526-14nfqusv 164 1 RNA RNA NNP cord-271526-14nfqusv 164 2 was be VBD cord-271526-14nfqusv 164 3 constructed construct VBN cord-271526-14nfqusv 164 4 . . . cord-271526-14nfqusv 165 1 This this DT cord-271526-14nfqusv 165 2 RNA RNA NNP cord-271526-14nfqusv 165 3 is be VBZ cord-271526-14nfqusv 165 4 identical identical JJ cord-271526-14nfqusv 165 5 to to IN cord-271526-14nfqusv 165 6 Ps180 Ps180 NNP cord-271526-14nfqusv 165 7 RNA RNA NNP cord-271526-14nfqusv 165 8 except except IN cord-271526-14nfqusv 165 9 that that IN cord-271526-14nfqusv 165 10 the the DT cord-271526-14nfqusv 165 11 largest large JJS cord-271526-14nfqusv 165 12 part part NN cord-271526-14nfqusv 165 13 of of IN cord-271526-14nfqusv 165 14 the the DT cord-271526-14nfqusv 165 15 69-nt 69-nt CD cord-271526-14nfqusv 166 1 Ps ps UH cord-271526-14nfqusv 166 2 hairpin hairpin NN cord-271526-14nfqusv 166 3 has have VBZ cord-271526-14nfqusv 166 4 been be VBN cord-271526-14nfqusv 166 5 removed remove VBN cord-271526-14nfqusv 166 6 . . . cord-271526-14nfqusv 167 1 The the DT cord-271526-14nfqusv 167 2 U U NNP cord-271526-14nfqusv 167 3 contents content NNS cord-271526-14nfqusv 167 4 of of IN cord-271526-14nfqusv 167 5 Ps180 ps180 NN cord-271526-14nfqusv 167 6 and and CC cord-271526-14nfqusv 167 7 PsDHP PsDHP NNP cord-271526-14nfqusv 167 8 are be VBP cord-271526-14nfqusv 167 9 similar similar JJ cord-271526-14nfqusv 167 10 ( ( -LRB- cord-271526-14nfqusv 167 11 approx approx NN cord-271526-14nfqusv 167 12 . . . cord-271526-14nfqusv 167 13 25 25 CD cord-271526-14nfqusv 167 14 % % NN cord-271526-14nfqusv 167 15 ) ) -RRB- cord-271526-14nfqusv 167 16 . . . cord-271526-14nfqusv 168 1 Pilot pilot NN cord-271526-14nfqusv 168 2 experiments experiment NNS cord-271526-14nfqusv 168 3 were be VBD cord-271526-14nfqusv 168 4 performed perform VBN cord-271526-14nfqusv 168 5 to to TO cord-271526-14nfqusv 168 6 estimate estimate VB cord-271526-14nfqusv 168 7 the the DT cord-271526-14nfqusv 168 8 optimal optimal JJ cord-271526-14nfqusv 168 9 UV uv NN cord-271526-14nfqusv 168 10 dose dose NN cord-271526-14nfqusv 168 11 . . . cord-271526-14nfqusv 169 1 From from IN cord-271526-14nfqusv 169 2 these these DT cord-271526-14nfqusv 169 3 experiments experiment NNS cord-271526-14nfqusv 169 4 it -PRON- PRP cord-271526-14nfqusv 169 5 was be VBD cord-271526-14nfqusv 169 6 determined determine VBN cord-271526-14nfqusv 169 7 that that IN cord-271526-14nfqusv 169 8 an an DT cord-271526-14nfqusv 169 9 UV uv NN cord-271526-14nfqusv 169 10 dose dose NN cord-271526-14nfqusv 169 11 of of IN cord-271526-14nfqusv 169 12 1.8 1.8 CD cord-271526-14nfqusv 169 13 J J NNP cord-271526-14nfqusv 169 14 / / SYM cord-271526-14nfqusv 169 15 cm cm NNP cord-271526-14nfqusv 169 16 2 2 CD cord-271526-14nfqusv 169 17 gave give VBD cord-271526-14nfqusv 169 18 the the DT cord-271526-14nfqusv 169 19 most most RBS cord-271526-14nfqusv 169 20 distinct distinct JJ cord-271526-14nfqusv 169 21 bands band NNS cord-271526-14nfqusv 169 22 with with IN cord-271526-14nfqusv 169 23 the the DT cord-271526-14nfqusv 169 24 least least JJS cord-271526-14nfqusv 169 25 background background NN cord-271526-14nfqusv 169 26 ( ( -LRB- cord-271526-14nfqusv 169 27 data datum NNS cord-271526-14nfqusv 169 28 not not RB cord-271526-14nfqusv 169 29 shown show VBN cord-271526-14nfqusv 169 30 ) ) -RRB- cord-271526-14nfqusv 169 31 . . . cord-271526-14nfqusv 170 1 from from IN cord-271526-14nfqusv 170 2 uninfected uninfected JJ cord-271526-14nfqusv 170 3 cells cell NNS cord-271526-14nfqusv 170 4 was be VBD cord-271526-14nfqusv 170 5 added add VBN cord-271526-14nfqusv 170 6 as as IN cord-271526-14nfqusv 170 7 nonspecific nonspecific JJ cord-271526-14nfqusv 170 8 competi competi NN cord-271526-14nfqusv 170 9 - - : cord-271526-14nfqusv 170 10 observed observe VBN cord-271526-14nfqusv 170 11 using use VBG cord-271526-14nfqusv 170 12 the the DT cord-271526-14nfqusv 170 13 vTF7-lysate vTF7-lysate : cord-271526-14nfqusv 170 14 ( ( -LRB- cord-271526-14nfqusv 170 15 Fig Fig NNP cord-271526-14nfqusv 170 16 . . . cord-271526-14nfqusv 170 17 6C 6C NNP cord-271526-14nfqusv 170 18 , , , cord-271526-14nfqusv 170 19 lane lane NN cord-271526-14nfqusv 170 20 2 2 CD cord-271526-14nfqusv 170 21 ) ) -RRB- cord-271526-14nfqusv 170 22 . . . cord-271526-14nfqusv 171 1 These these DT cord-271526-14nfqusv 171 2 experiments experiment NNS cord-271526-14nfqusv 171 3 clearly clearly RB cord-271526-14nfqusv 171 4 demonstrate demonstrate VBP cord-271526-14nfqusv 171 5 that that IN cord-271526-14nfqusv 171 6 no no DT cord-271526-14nfqusv 171 7 virus virus NN cord-271526-14nfqusv 171 8 specific specific JJ cord-271526-14nfqusv 171 9 modifications modification NNS cord-271526-14nfqusv 171 10 of of IN cord-271526-14nfqusv 171 11 the the DT cord-271526-14nfqusv 171 12 N N NNP cord-271526-14nfqusv 171 13 protein protein NN cord-271526-14nfqusv 171 14 or or CC cord-271526-14nfqusv 171 15 any any DT cord-271526-14nfqusv 171 16 other other JJ cord-271526-14nfqusv 171 17 viral viral JJ cord-271526-14nfqusv 171 18 proteins protein NNS cord-271526-14nfqusv 171 19 are be VBP cord-271526-14nfqusv 171 20 required require VBN cord-271526-14nfqusv 171 21 for for IN cord-271526-14nfqusv 171 22 the the DT cord-271526-14nfqusv 171 23 specific specific JJ cord-271526-14nfqusv 171 24 interaction interaction NN cord-271526-14nfqusv 171 25 with with IN cord-271526-14nfqusv 171 26 Ps180 Ps180 NNP cord-271526-14nfqusv 171 27 . . . cord-271526-14nfqusv 172 1 Initiation initiation NN cord-271526-14nfqusv 172 2 of of IN cord-271526-14nfqusv 172 3 encapsidation encapsidation NN cord-271526-14nfqusv 172 4 by by IN cord-271526-14nfqusv 172 5 a a DT cord-271526-14nfqusv 172 6 specific specific JJ cord-271526-14nfqusv 172 7 interaction interaction NN cord-271526-14nfqusv 172 8 between between IN cord-271526-14nfqusv 172 9 the the DT cord-271526-14nfqusv 172 10 ( ( -LRB- cord-271526-14nfqusv 172 11 nucleo- nucleo- RB cord-271526-14nfqusv 172 12 ) ) -RRB- cord-271526-14nfqusv 172 13 capsid capsid NN cord-271526-14nfqusv 172 14 protein protein NN cord-271526-14nfqusv 172 15 and and CC cord-271526-14nfqusv 172 16 a a DT cord-271526-14nfqusv 172 17 RNA RNA NNP cord-271526-14nfqusv 172 18 packaging packaging NN cord-271526-14nfqusv 172 19 signal signal NN cord-271526-14nfqusv 172 20 is be VBZ cord-271526-14nfqusv 172 21 a a DT cord-271526-14nfqusv 172 22 common common JJ cord-271526-14nfqusv 172 23 mechanism mechanism NN cord-271526-14nfqusv 172 24 used use VBN cord-271526-14nfqusv 172 25 by by IN cord-271526-14nfqusv 172 26 positive positive JJ cord-271526-14nfqusv 172 27 stranded strand VBN cord-271526-14nfqusv 172 28 RNA RNA NNP cord-271526-14nfqusv 172 29 viruses virus NNS cord-271526-14nfqusv 172 30 . . . cord-271526-14nfqusv 173 1 Such such PDT cord-271526-14nfqusv 173 2 an an DT cord-271526-14nfqusv 173 3 interaction interaction NN cord-271526-14nfqusv 173 4 has have VBZ cord-271526-14nfqusv 173 5 already already RB cord-271526-14nfqusv 173 6 Weis Weis NNP cord-271526-14nfqusv 173 7 et et NNP cord-271526-14nfqusv 173 8 al al NNP cord-271526-14nfqusv 173 9 . . NNP cord-271526-14nfqusv 173 10 , , , cord-271526-14nfqusv 173 11 1989 1989 CD cord-271526-14nfqusv 173 12 ) ) -RRB- cord-271526-14nfqusv 173 13 , , , cord-271526-14nfqusv 173 14 retroviruses retrovirus NNS cord-271526-14nfqusv 173 15 ( ( -LRB- cord-271526-14nfqusv 173 16 Zhang Zhang NNP cord-271526-14nfqusv 173 17 were be VBD cord-271526-14nfqusv 173 18 immunoprecipitated immunoprecipitate VBN cord-271526-14nfqusv 173 19 with with IN cord-271526-14nfqusv 173 20 N n CD cord-271526-14nfqusv 173 21 - - HYPH cord-271526-14nfqusv 173 22 specific specific JJ cord-271526-14nfqusv 173 23 monoclonal monoclonal JJ cord-271526-14nfqusv 173 24 antibody antibody NN cord-271526-14nfqusv 173 25 and and CC cord-271526-14nfqusv 173 26 Barklis Barklis NNP cord-271526-14nfqusv 173 27 , , , cord-271526-14nfqusv 173 28 1995 1995 CD cord-271526-14nfqusv 173 29 ; ; : cord-271526-14nfqusv 173 30 Berkowitz Berkowitz NNP cord-271526-14nfqusv 173 31 et et NNP cord-271526-14nfqusv 173 32 al al NNP cord-271526-14nfqusv 173 33 . . NNP cord-271526-14nfqusv 173 34 , , , cord-271526-14nfqusv 173 35 1995 1995 CD cord-271526-14nfqusv 173 36 ; ; : cord-271526-14nfqusv 173 37 Dupraz Dupraz NNP cord-271526-14nfqusv 173 38 and and CC cord-271526-14nfqusv 173 39 5B188.2 5b188.2 CD cord-271526-14nfqusv 173 40 . . . cord-271526-14nfqusv 174 1 Competition competition NN cord-271526-14nfqusv 174 2 was be VBD cord-271526-14nfqusv 174 3 performed perform VBN cord-271526-14nfqusv 174 4 with with IN cord-271526-14nfqusv 174 5 unlabeled unlabeled JJ cord-271526-14nfqusv 174 6 Ps180 Ps180 NNP cord-271526-14nfqusv 174 7 RNA RNA NNP cord-271526-14nfqusv 174 8 or or CC cord-271526-14nfqusv 174 9 yeast yeast NN cord-271526-14nfqusv 174 10 tRNA tRNA NNP cord-271526-14nfqusv 174 11 as as IN cord-271526-14nfqusv 174 12 indicated indicate VBN cord-271526-14nfqusv 174 13 above above IN cord-271526-14nfqusv 174 14 the the DT cord-271526-14nfqusv 174 15 lanes lane NNS cord-271526-14nfqusv 174 16 . . . cord-271526-14nfqusv 175 1 The the DT cord-271526-14nfqusv 175 2 position position NN cord-271526-14nfqusv 175 3 of of IN cord-271526-14nfqusv 175 4 the the DT cord-271526-14nfqusv 175 5 N n CD cord-271526-14nfqusv 175 6 - - HYPH cord-271526-14nfqusv 175 7 protein protein NN cord-271526-14nfqusv 175 8 Spahr Spahr NNP cord-271526-14nfqusv 175 9 , , , cord-271526-14nfqusv 175 10 1992 1992 CD cord-271526-14nfqusv 175 11 ; ; : cord-271526-14nfqusv 175 12 Aldovini Aldovini NNP cord-271526-14nfqusv 175 13 and and CC cord-271526-14nfqusv 175 14 Young Young NNP cord-271526-14nfqusv 175 15 , , , cord-271526-14nfqusv 175 16 1990 1990 CD cord-271526-14nfqusv 175 17 ) ) -RRB- cord-271526-14nfqusv 175 18 but but CC cord-271526-14nfqusv 175 19 also also RB cord-271526-14nfqusv 175 20 in in IN cord-271526-14nfqusv 175 21 E. E. NNP cord-271526-14nfqusv 175 22 coli coli VBZ cord-271526-14nfqusv 175 23 specific specific JJ cord-271526-14nfqusv 175 24 band band NN cord-271526-14nfqusv 175 25 is be VBZ cord-271526-14nfqusv 175 26 indicated indicate VBN cord-271526-14nfqusv 175 27 . . . cord-271526-14nfqusv 176 1 bacteriophages bacteriophage NNS cord-271526-14nfqusv 176 2 like like IN cord-271526-14nfqusv 176 3 R17 R17 NNP cord-271526-14nfqusv 176 4 and and CC cord-271526-14nfqusv 176 5 MS2 MS2 NNP cord-271526-14nfqusv 176 6 ( ( -LRB- cord-271526-14nfqusv 176 7 Witherell Witherell NNP cord-271526-14nfqusv 176 8 et et NNP cord-271526-14nfqusv 176 9 al al NNP cord-271526-14nfqusv 176 10 . . NNP cord-271526-14nfqusv 176 11 , , , cord-271526-14nfqusv 176 12 1991 1991 CD cord-271526-14nfqusv 176 13 ) ) -RRB- cord-271526-14nfqusv 176 14 . . . cord-271526-14nfqusv 177 1 In in IN cord-271526-14nfqusv 177 2 this this DT cord-271526-14nfqusv 177 3 report report NN cord-271526-14nfqusv 177 4 we -PRON- PRP cord-271526-14nfqusv 177 5 describe describe VBP cord-271526-14nfqusv 177 6 the the DT cord-271526-14nfqusv 177 7 specific specific JJ cord-271526-14nfqusv 177 8 in in IN cord-271526-14nfqusv 177 9 vitro vitro FW cord-271526-14nfqusv 177 10 interaction interaction NN cord-271526-14nfqusv 177 11 of of IN cord-271526-14nfqusv 177 12 the the DT cord-271526-14nfqusv 177 13 mouse mouse NN cord-271526-14nfqusv 177 14 hepatitis hepatitis NN cord-271526-14nfqusv 177 15 virus virus NN cord-271526-14nfqusv 177 16 A59 A59 NNP cord-271526-14nfqusv 177 17 N N NNP cord-271526-14nfqusv 177 18 protein protein NN cord-271526-14nfqusv 177 19 with with IN cord-271526-14nfqusv 177 20 tranact tranact NNP cord-271526-14nfqusv 177 21 specifically specifically RB cord-271526-14nfqusv 177 22 with with IN cord-271526-14nfqusv 177 23 Ps180 Ps180 NNP cord-271526-14nfqusv 177 24 . . . cord-271526-14nfqusv 178 1 In in IN cord-271526-14nfqusv 178 2 order order NN cord-271526-14nfqusv 178 3 to to TO cord-271526-14nfqusv 178 4 address address VB cord-271526-14nfqusv 178 5 this this DT cord-271526-14nfqusv 178 6 quesscripts quesscripts NN cord-271526-14nfqusv 178 7 containing contain VBG cord-271526-14nfqusv 178 8 the the DT cord-271526-14nfqusv 178 9 RNA RNA NNP cord-271526-14nfqusv 178 10 packaging packaging NN cord-271526-14nfqusv 178 11 signal signal NN cord-271526-14nfqusv 178 12 of of IN cord-271526-14nfqusv 178 13 MHV MHV NNP cord-271526-14nfqusv 178 14 . . . cord-271526-14nfqusv 179 1 tion tion NN cord-271526-14nfqusv 179 2 , , , cord-271526-14nfqusv 179 3 virus virus NN cord-271526-14nfqusv 179 4 particles particle NNS cord-271526-14nfqusv 179 5 were be VBD cord-271526-14nfqusv 179 6 purified purify VBN cord-271526-14nfqusv 179 7 on on IN cord-271526-14nfqusv 179 8 a a DT cord-271526-14nfqusv 179 9 sucrose sucrose NN cord-271526-14nfqusv 179 10 gradient gradient NN cord-271526-14nfqusv 179 11 . . . cord-271526-14nfqusv 180 1 This this DT cord-271526-14nfqusv 180 2 interaction interaction NN cord-271526-14nfqusv 180 3 was be VBD cord-271526-14nfqusv 180 4 studied study VBN cord-271526-14nfqusv 180 5 by by IN cord-271526-14nfqusv 180 6 gel gel NN cord-271526-14nfqusv 180 7 retardation retardation NN cord-271526-14nfqusv 180 8 and and CC cord-271526-14nfqusv 180 9 UV UV NNP cord-271526-14nfqusv 180 10 Lysates Lysates NNPS cord-271526-14nfqusv 180 11 were be VBD cord-271526-14nfqusv 180 12 prepared prepare VBN cord-271526-14nfqusv 180 13 from from IN cord-271526-14nfqusv 180 14 the the DT cord-271526-14nfqusv 180 15 virus virus NN cord-271526-14nfqusv 180 16 peak peak NN cord-271526-14nfqusv 180 17 fractions fraction NNS cord-271526-14nfqusv 180 18 ( ( -LRB- cord-271526-14nfqusv 180 19 pcross pcross NN cord-271526-14nfqusv 180 20 - - HYPH cord-271526-14nfqusv 180 21 linking link VBG cord-271526-14nfqusv 180 22 assays assay NNS cord-271526-14nfqusv 180 23 using use VBG cord-271526-14nfqusv 180 24 an an DT cord-271526-14nfqusv 180 25 RNA RNA NNP cord-271526-14nfqusv 180 26 probe probe NN cord-271526-14nfqusv 180 27 containing contain VBG cord-271526-14nfqusv 180 28 the the DT cord-271526-14nfqusv 180 29 lysate lysate NN cord-271526-14nfqusv 180 30 ) ) -RRB- cord-271526-14nfqusv 180 31 and and CC cord-271526-14nfqusv 180 32 from from IN cord-271526-14nfqusv 180 33 the the DT cord-271526-14nfqusv 180 34 gradient gradient NN cord-271526-14nfqusv 180 35 bottom bottom NN cord-271526-14nfqusv 180 36 fractions fraction NNS cord-271526-14nfqusv 180 37 ( ( -LRB- cord-271526-14nfqusv 180 38 b b NN cord-271526-14nfqusv 180 39 - - HYPH cord-271526-14nfqusv 180 40 lysate lysate NN cord-271526-14nfqusv 180 41 ; ; : cord-271526-14nfqusv 180 42 69-nt 69-nt CD cord-271526-14nfqusv 181 1 Ps Ps NNP cord-271526-14nfqusv 181 2 and and CC cord-271526-14nfqusv 181 3 the the DT cord-271526-14nfqusv 181 4 N n CD cord-271526-14nfqusv 181 5 protein protein NN cord-271526-14nfqusv 181 6 from from IN cord-271526-14nfqusv 181 7 MHV MHV NNP cord-271526-14nfqusv 181 8 - - HYPH cord-271526-14nfqusv 181 9 A59 A59 NNP cord-271526-14nfqusv 181 10 infected infected JJ cord-271526-14nfqusv 181 11 cell cell NN cord-271526-14nfqusv 181 12 negative negative JJ cord-271526-14nfqusv 181 13 control control NN cord-271526-14nfqusv 181 14 ) ) -RRB- cord-271526-14nfqusv 181 15 . . . cord-271526-14nfqusv 182 1 UV UV NNP cord-271526-14nfqusv 182 2 cross cross NN cord-271526-14nfqusv 182 3 - - NN cord-271526-14nfqusv 182 4 linking linking NN cord-271526-14nfqusv 182 5 was be VBD cord-271526-14nfqusv 182 6 performed perform VBN cord-271526-14nfqusv 182 7 using use VBG cord-271526-14nfqusv 182 8 lysates lysate NNS cord-271526-14nfqusv 182 9 . . . cord-271526-14nfqusv 183 1 A a DT cord-271526-14nfqusv 183 2 similar similar JJ cord-271526-14nfqusv 183 3 interaction interaction NN cord-271526-14nfqusv 183 4 was be VBD cord-271526-14nfqusv 183 5 identified identify VBN cord-271526-14nfqusv 183 6 between between IN cord-271526-14nfqusv 183 7 the the DT cord-271526-14nfqusv 183 8 both both DT cord-271526-14nfqusv 183 9 lysates lysate NNS cord-271526-14nfqusv 183 10 , , , cord-271526-14nfqusv 183 11 radiolabeled radiolabele VBD cord-271526-14nfqusv 183 12 Ps180 Ps180 NNP cord-271526-14nfqusv 183 13 RNA RNA NNP cord-271526-14nfqusv 183 14 , , , cord-271526-14nfqusv 183 15 and and CC cord-271526-14nfqusv 183 16 competitor competitor NN cord-271526-14nfqusv 183 17 N n CD cord-271526-14nfqusv 183 18 protein protein NN cord-271526-14nfqusv 183 19 from from IN cord-271526-14nfqusv 183 20 purified purify VBN cord-271526-14nfqusv 183 21 virus virus NN cord-271526-14nfqusv 183 22 and and CC cord-271526-14nfqusv 183 23 recombinant recombinant JJ cord-271526-14nfqusv 183 24 N n CD cord-271526-14nfqusv 183 25 - - HYPH cord-271526-14nfqusv 183 26 protein protein NN cord-271526-14nfqusv 183 27 RNA RNA NNP cord-271526-14nfqusv 183 28 ( ( -LRB- cord-271526-14nfqusv 183 29 5 5 CD cord-271526-14nfqusv 183 30 mg mg NN cord-271526-14nfqusv 183 31 of of IN cord-271526-14nfqusv 183 32 total total JJ cord-271526-14nfqusv 183 33 cytoplasmic cytoplasmic JJ cord-271526-14nfqusv 183 34 RNA RNA NNP cord-271526-14nfqusv 183 35 extracted extract VBN cord-271526-14nfqusv 183 36 from from IN cord-271526-14nfqusv 183 37 uninexpressed uninexpressed JJ cord-271526-14nfqusv 183 38 by by IN cord-271526-14nfqusv 183 39 the the DT cord-271526-14nfqusv 183 40 vTF7 vTF7 NNP cord-271526-14nfqusv 183 41 expression expression NN cord-271526-14nfqusv 183 42 system system NN cord-271526-14nfqusv 183 43 . . . cord-271526-14nfqusv 184 1 fected fected JJ cord-271526-14nfqusv 184 2 cells cell NNS cord-271526-14nfqusv 184 3 ; ; : cord-271526-14nfqusv 184 4 Fig Fig NNP cord-271526-14nfqusv 184 5 . . . cord-271526-14nfqusv 184 6 6B 6b CD cord-271526-14nfqusv 184 7 ) ) -RRB- cord-271526-14nfqusv 184 8 . . . cord-271526-14nfqusv 185 1 A a DT cord-271526-14nfqusv 185 2 specific specific JJ cord-271526-14nfqusv 185 3 interaction interaction NN cord-271526-14nfqusv 185 4 was be VBD cord-271526-14nfqusv 185 5 observed observe VBN cord-271526-14nfqusv 185 6 In in IN cord-271526-14nfqusv 185 7 addition addition NN cord-271526-14nfqusv 185 8 to to IN cord-271526-14nfqusv 185 9 the the DT cord-271526-14nfqusv 185 10 N N NNP cord-271526-14nfqusv 185 11 - - HYPH cord-271526-14nfqusv 185 12 Ps Ps NNP cord-271526-14nfqusv 185 13 RNA RNA NNP cord-271526-14nfqusv 185 14 complex complex NN cord-271526-14nfqusv 185 15 we -PRON- PRP cord-271526-14nfqusv 185 16 also also RB cord-271526-14nfqusv 185 17 observed observe VBD cord-271526-14nfqusv 185 18 between between IN cord-271526-14nfqusv 185 19 the the DT cord-271526-14nfqusv 185 20 N n NN cord-271526-14nfqusv 185 21 - - HYPH cord-271526-14nfqusv 185 22 protein protein NN cord-271526-14nfqusv 185 23 from from IN cord-271526-14nfqusv 185 24 the the DT cord-271526-14nfqusv 185 25 p p NN cord-271526-14nfqusv 185 26 - - HYPH cord-271526-14nfqusv 185 27 lysate lysate NN cord-271526-14nfqusv 185 28 and and CC cord-271526-14nfqusv 185 29 Ps180 Ps180 NNP cord-271526-14nfqusv 185 30 RNA RNA NNP cord-271526-14nfqusv 185 31 that that IN cord-271526-14nfqusv 185 32 cellular cellular JJ cord-271526-14nfqusv 185 33 proteins protein NNS cord-271526-14nfqusv 185 34 bind bind VBP cord-271526-14nfqusv 185 35 to to IN cord-271526-14nfqusv 185 36 Ps Ps NNP cord-271526-14nfqusv 185 37 containing contain VBG cord-271526-14nfqusv 185 38 RNAs rna NNS cord-271526-14nfqusv 185 39 . . . cord-271526-14nfqusv 186 1 The the DT cord-271526-14nfqusv 186 2 ( ( -LRB- cord-271526-14nfqusv 186 3 Fig Fig NNP cord-271526-14nfqusv 186 4 . . . cord-271526-14nfqusv 186 5 6B 6b CD cord-271526-14nfqusv 186 6 , , , cord-271526-14nfqusv 186 7 lanes lane NNS cord-271526-14nfqusv 186 8 2 2 CD cord-271526-14nfqusv 186 9 and and CC cord-271526-14nfqusv 186 10 4 4 CD cord-271526-14nfqusv 186 11 ) ) -RRB- cord-271526-14nfqusv 186 12 . . . cord-271526-14nfqusv 187 1 In in IN cord-271526-14nfqusv 187 2 contrast contrast NN cord-271526-14nfqusv 187 3 , , , cord-271526-14nfqusv 187 4 no no DT cord-271526-14nfqusv 187 5 complex complex NN cord-271526-14nfqusv 187 6 could could MD cord-271526-14nfqusv 187 7 nature nature NN cord-271526-14nfqusv 187 8 of of IN cord-271526-14nfqusv 187 9 these these DT cord-271526-14nfqusv 187 10 cellular cellular JJ cord-271526-14nfqusv 187 11 proteins protein NNS cord-271526-14nfqusv 187 12 and and CC cord-271526-14nfqusv 187 13 the the DT cord-271526-14nfqusv 187 14 significance significance NN cord-271526-14nfqusv 187 15 of of IN cord-271526-14nfqusv 187 16 be be VB cord-271526-14nfqusv 187 17 immunoprecipitated immunoprecipitate VBN cord-271526-14nfqusv 187 18 with with IN cord-271526-14nfqusv 187 19 N n CD cord-271526-14nfqusv 187 20 - - HYPH cord-271526-14nfqusv 187 21 specific specific JJ cord-271526-14nfqusv 187 22 antibodies antibody NNS cord-271526-14nfqusv 187 23 when when WRB cord-271526-14nfqusv 187 24 this this DT cord-271526-14nfqusv 187 25 interaction interaction NN cord-271526-14nfqusv 187 26 , , , cord-271526-14nfqusv 187 27 however however RB cord-271526-14nfqusv 187 28 , , , cord-271526-14nfqusv 187 29 remains remain VBZ cord-271526-14nfqusv 187 30 unclear unclear JJ cord-271526-14nfqusv 187 31 . . . cord-271526-14nfqusv 188 1 the the DT cord-271526-14nfqusv 188 2 b b NN cord-271526-14nfqusv 188 3 - - HYPH cord-271526-14nfqusv 188 4 lysate lysate NN cord-271526-14nfqusv 188 5 was be VBD cord-271526-14nfqusv 188 6 used use VBN cord-271526-14nfqusv 189 1 ( ( -LRB- cord-271526-14nfqusv 189 2 Fig Fig NNP cord-271526-14nfqusv 189 3 . . . cord-271526-14nfqusv 189 4 6B 6b CD cord-271526-14nfqusv 189 5 , , , cord-271526-14nfqusv 189 6 lanes lane NNS cord-271526-14nfqusv 189 7 1 1 CD cord-271526-14nfqusv 189 8 and and CC cord-271526-14nfqusv 189 9 3 3 CD cord-271526-14nfqusv 189 10 ) ) -RRB- cord-271526-14nfqusv 189 11 . . . cord-271526-14nfqusv 190 1 This this DT cord-271526-14nfqusv 190 2 indicates indicate VBZ cord-271526-14nfqusv 190 3 that that IN cord-271526-14nfqusv 190 4 any any DT cord-271526-14nfqusv 190 5 structural structural JJ cord-271526-14nfqusv 190 6 change change NN cord-271526-14nfqusv 190 7 of of IN cord-271526-14nfqusv 190 8 the the DT cord-271526-14nfqusv 190 9 N N NNP cord-271526-14nfqusv 190 10 protein protein NN cord-271526-14nfqusv 190 11 which which WDT cord-271526-14nfqusv 190 12 might may MD cord-271526-14nfqusv 190 13 occur occur VB cord-271526-14nfqusv 190 14 during during IN cord-271526-14nfqusv 190 15 virus virus NN cord-271526-14nfqusv 190 16 assembly assembly NN cord-271526-14nfqusv 190 17 does do VBZ cord-271526-14nfqusv 190 18 not not RB cord-271526-14nfqusv 190 19 affect affect VB cord-271526-14nfqusv 190 20 the the DT cord-271526-14nfqusv 190 21 ability ability NN cord-271526-14nfqusv 190 22 of of IN cord-271526-14nfqusv 190 23 the the DT cord-271526-14nfqusv 190 24 N n CD cord-271526-14nfqusv 190 25 protein protein NN cord-271526-14nfqusv 190 26 to to TO cord-271526-14nfqusv 190 27 interact interact VB cord-271526-14nfqusv 190 28 with with IN cord-271526-14nfqusv 190 29 Ps180 Ps180 NNP cord-271526-14nfqusv 190 30 RNA RNA NNP cord-271526-14nfqusv 190 31 . . . cord-271526-14nfqusv 191 1 In in IN cord-271526-14nfqusv 191 2 MHV mhv NN cord-271526-14nfqusv 191 3 - - HYPH cord-271526-14nfqusv 191 4 infected infect VBN cord-271526-14nfqusv 191 5 cells cell NNS cord-271526-14nfqusv 191 6 , , , cord-271526-14nfqusv 191 7 the the DT cord-271526-14nfqusv 191 8 N n CD cord-271526-14nfqusv 191 9 protein protein NN cord-271526-14nfqusv 191 10 might may MD cord-271526-14nfqusv 191 11 also also RB cord-271526-14nfqusv 191 12 undergo undergo VB cord-271526-14nfqusv 191 13 virus virus NN cord-271526-14nfqusv 191 14 - - HYPH cord-271526-14nfqusv 191 15 specific specific JJ cord-271526-14nfqusv 191 16 or or CC cord-271526-14nfqusv 191 17 virus virus NN cord-271526-14nfqusv 191 18 - - HYPH cord-271526-14nfqusv 191 19 dependent dependent JJ cord-271526-14nfqusv 191 20 posttranslational posttranslational JJ cord-271526-14nfqusv 191 21 modifications modification NNS cord-271526-14nfqusv 191 22 . . . cord-271526-14nfqusv 192 1 These these DT cord-271526-14nfqusv 192 2 modifications modification NNS cord-271526-14nfqusv 192 3 might may MD cord-271526-14nfqusv 192 4 play play VB cord-271526-14nfqusv 192 5 a a DT cord-271526-14nfqusv 192 6 role role NN cord-271526-14nfqusv 192 7 in in IN cord-271526-14nfqusv 192 8 the the DT cord-271526-14nfqusv 192 9 specific specific JJ cord-271526-14nfqusv 192 10 interaction interaction NN cord-271526-14nfqusv 192 11 with with IN cord-271526-14nfqusv 192 12 the the DT cord-271526-14nfqusv 192 13 Ps Ps NNP cord-271526-14nfqusv 192 14 . . . cord-271526-14nfqusv 193 1 Furthermore furthermore RB cord-271526-14nfqusv 193 2 , , , cord-271526-14nfqusv 193 3 it -PRON- PRP cord-271526-14nfqusv 193 4 is be VBZ cord-271526-14nfqusv 193 5 not not RB cord-271526-14nfqusv 193 6 yet yet RB cord-271526-14nfqusv 193 7 known know VBN cord-271526-14nfqusv 193 8 if if IN cord-271526-14nfqusv 193 9 the the DT cord-271526-14nfqusv 193 10 interaction interaction NN cord-271526-14nfqusv 193 11 between between IN cord-271526-14nfqusv 193 12 the the DT cord-271526-14nfqusv 193 13 N N NNP cord-271526-14nfqusv 193 14 protein protein NN cord-271526-14nfqusv 193 15 and and CC cord-271526-14nfqusv 193 16 the the DT cord-271526-14nfqusv 193 17 Ps Ps NNP cord-271526-14nfqusv 193 18 involves involve VBZ cord-271526-14nfqusv 193 19 other other JJ cord-271526-14nfqusv 193 20 viral viral JJ cord-271526-14nfqusv 193 21 proteins protein NNS cord-271526-14nfqusv 193 22 as as RB cord-271526-14nfqusv 193 23 well well RB cord-271526-14nfqusv 193 24 . . . cord-271526-14nfqusv 194 1 In in IN cord-271526-14nfqusv 194 2 order order NN cord-271526-14nfqusv 194 3 to to TO cord-271526-14nfqusv 194 4 investigate investigate VB cord-271526-14nfqusv 194 5 this this DT cord-271526-14nfqusv 194 6 , , , cord-271526-14nfqusv 194 7 recombinant recombinant JJ cord-271526-14nfqusv 194 8 N n CD cord-271526-14nfqusv 194 9 protein protein NN cord-271526-14nfqusv 194 10 was be VBD cord-271526-14nfqusv 194 11 expressed express VBN cord-271526-14nfqusv 194 12 by by IN cord-271526-14nfqusv 194 13 the the DT cord-271526-14nfqusv 194 14 vTF7.3 vTF7.3 NNP cord-271526-14nfqusv 194 15 expression expression NN cord-271526-14nfqusv 194 16 system system NN cord-271526-14nfqusv 194 17 . . . cord-271526-14nfqusv 195 1 A a DT cord-271526-14nfqusv 195 2 N n CD cord-271526-14nfqusv 195 3 protein protein NN cord-271526-14nfqusv 195 4 expression expression NN cord-271526-14nfqusv 195 5 vector vector NN cord-271526-14nfqusv 195 6 ( ( -LRB- cord-271526-14nfqusv 195 7 pEMCV pEMCV NNP cord-271526-14nfqusv 195 8 - - HYPH cord-271526-14nfqusv 195 9 N N NNP cord-271526-14nfqusv 195 10 ) ) -RRB- cord-271526-14nfqusv 195 11 was be VBD cord-271526-14nfqusv 195 12 transfected transfecte VBN cord-271526-14nfqusv 195 13 in in IN cord-271526-14nfqusv 195 14 vTF7.3-infected vTF7.3-infected NNP cord-271526-14nfqusv 195 15 RK13 RK13 NNP cord-271526-14nfqusv 195 16 cells cell NNS cord-271526-14nfqusv 195 17 and and CC cord-271526-14nfqusv 195 18 protein protein NN cord-271526-14nfqusv 195 19 lysates lysate NNS cord-271526-14nfqusv 195 20 were be VBD cord-271526-14nfqusv 195 21 made make VBN cord-271526-14nfqusv 195 22 16 16 CD cord-271526-14nfqusv 195 23 h h NN cord-271526-14nfqusv 195 24 posttransfection posttransfection NN cord-271526-14nfqusv 195 25 ( ( -LRB- cord-271526-14nfqusv 195 26 vTF7pN vTF7pN : cord-271526-14nfqusv 195 27 lysate lysate NN cord-271526-14nfqusv 195 28 ) ) -RRB- cord-271526-14nfqusv 195 29 . . . cord-271526-14nfqusv 196 1 As as IN cord-271526-14nfqusv 196 2 a a DT cord-271526-14nfqusv 196 3 control control NN cord-271526-14nfqusv 196 4 protein protein NN cord-271526-14nfqusv 196 5 lysates lysate NNS cord-271526-14nfqusv 196 6 from from IN cord-271526-14nfqusv 196 7 mock mock NN cord-271526-14nfqusv 196 8 - - HYPH cord-271526-14nfqusv 196 9 transfected transfecte VBN cord-271526-14nfqusv 196 10 but but CC cord-271526-14nfqusv 196 11 vTF7.3-infected vtf7.3-infected JJ cord-271526-14nfqusv 196 12 RK13 RK13 NNP cord-271526-14nfqusv 196 13 cells cell NNS cord-271526-14nfqusv 196 14 were be VBD cord-271526-14nfqusv 196 15 made make VBN cord-271526-14nfqusv 196 16 ( ( -LRB- cord-271526-14nfqusv 196 17 vTF7-lysate vtf7-lysate NN cord-271526-14nfqusv 196 18 ) ) -RRB- cord-271526-14nfqusv 196 19 . . . cord-271526-14nfqusv 197 1 UV UV NNP cord-271526-14nfqusv 197 2 cross cross JJ cord-271526-14nfqusv 197 3 - - JJ cord-271526-14nfqusv 197 4 linking link VBG cord-271526-14nfqusv 197 5 experiments experiment NNS cord-271526-14nfqusv 197 6 , , , cord-271526-14nfqusv 197 7 followed follow VBN cord-271526-14nfqusv 197 8 by by IN cord-271526-14nfqusv 197 9 immunoprecipitation immunoprecipitation NN cord-271526-14nfqusv 197 10 with with IN cord-271526-14nfqusv 197 11 N n CD cord-271526-14nfqusv 197 12 - - HYPH cord-271526-14nfqusv 197 13 specific specific JJ cord-271526-14nfqusv 197 14 anti- anti- JJ cord-271526-14nfqusv 197 15 Fig fig NN cord-271526-14nfqusv 197 16 . . . cord-271526-14nfqusv 197 17 6C 6C NNP cord-271526-14nfqusv 197 18 ) ) -RRB- cord-271526-14nfqusv 197 19 . . . cord-271526-14nfqusv 198 1 Using use VBG cord-271526-14nfqusv 198 2 the the DT cord-271526-14nfqusv 198 3 vTF7pN vTF7pN , cord-271526-14nfqusv 198 4 lysate lysate NN cord-271526-14nfqusv 198 5 , , , cord-271526-14nfqusv 198 6 a a DT cord-271526-14nfqusv 198 7 clear clear JJ cord-271526-14nfqusv 198 8 band band NN cord-271526-14nfqusv 198 9 was be VBD cord-271526-14nfqusv 199 1 fraction fraction NN cord-271526-14nfqusv 199 2 lysate lysate NN cord-271526-14nfqusv 199 3 and and CC cord-271526-14nfqusv 199 4 p p NN cord-271526-14nfqusv 199 5 denotes denote VBZ cord-271526-14nfqusv 199 6 the the DT cord-271526-14nfqusv 199 7 peak peak NN cord-271526-14nfqusv 199 8 - - HYPH cord-271526-14nfqusv 199 9 fraction fraction NN cord-271526-14nfqusv 199 10 lysate lysate NN cord-271526-14nfqusv 199 11 . . . cord-271526-14nfqusv 200 1 Immunoprecipitaobserved Immunoprecipitaobserved NNP cord-271526-14nfqusv 200 2 migrating migrate VBG cord-271526-14nfqusv 200 3 at at IN cord-271526-14nfqusv 200 4 the the DT cord-271526-14nfqusv 200 5 expected expect VBN cord-271526-14nfqusv 200 6 position position NN cord-271526-14nfqusv 200 7 of of IN cord-271526-14nfqusv 200 8 the the DT cord-271526-14nfqusv 200 9 nution nution NN cord-271526-14nfqusv 200 10 with with IN cord-271526-14nfqusv 200 11 5B188.2 5b188.2 CD cord-271526-14nfqusv 200 12 and and CC cord-271526-14nfqusv 200 13 k134 k134 NN cord-271526-14nfqusv 200 14 were be VBD cord-271526-14nfqusv 200 15 performed perform VBN cord-271526-14nfqusv 200 16 as as IN cord-271526-14nfqusv 200 17 indicated indicate VBN cord-271526-14nfqusv 200 18 above above IN cord-271526-14nfqusv 200 19 the the DT cord-271526-14nfqusv 200 20 lanes lane NNS cord-271526-14nfqusv 200 21 . . . cord-271526-14nfqusv 201 1 The the DT cord-271526-14nfqusv 201 2 position position NN cord-271526-14nfqusv 201 3 of of IN cord-271526-14nfqusv 201 4 the the DT cord-271526-14nfqusv 201 5 N n CD cord-271526-14nfqusv 201 6 - - HYPH cord-271526-14nfqusv 201 7 protein protein NN cord-271526-14nfqusv 201 8 - - HYPH cord-271526-14nfqusv 201 9 specific specific JJ cord-271526-14nfqusv 201 10 band band NN cord-271526-14nfqusv 201 11 is be VBZ cord-271526-14nfqusv 201 12 indicated indicate VBN cord-271526-14nfqusv 201 13 . . . cord-271526-14nfqusv 202 1 cleocapsid cleocapsid NNP cord-271526-14nfqusv 202 2 protein protein NNP cord-271526-14nfqusv 202 3 ( ( -LRB- cord-271526-14nfqusv 202 4 Fig Fig NNP cord-271526-14nfqusv 202 5 . . . cord-271526-14nfqusv 202 6 6C 6C NNP cord-271526-14nfqusv 202 7 , , , cord-271526-14nfqusv 202 8 lane lane NN cord-271526-14nfqusv 202 9 1 1 CD cord-271526-14nfqusv 202 10 ) ) -RRB- cord-271526-14nfqusv 202 11 . . . cord-271526-14nfqusv 203 1 This this DT cord-271526-14nfqusv 203 2 band band NN cord-271526-14nfqusv 203 3 was be VBD cord-271526-14nfqusv 203 4 not not RB cord-271526-14nfqusv 203 5 The the DT cord-271526-14nfqusv 203 6 nature nature NN cord-271526-14nfqusv 203 7 of of IN cord-271526-14nfqusv 203 8 the the DT cord-271526-14nfqusv 203 9 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 203 10 protein protein NN cord-271526-14nfqusv 203 11 - - HYPH cord-271526-14nfqusv 203 12 Ps Ps NNP cord-271526-14nfqusv 203 13 RNA RNA NNP cord-271526-14nfqusv 203 14 cells cell NNS cord-271526-14nfqusv 204 1 ( ( -LRB- cord-271526-14nfqusv 204 2 Woo woo UH cord-271526-14nfqusv 204 3 et et FW cord-271526-14nfqusv 204 4 al al NNP cord-271526-14nfqusv 204 5 . . NNP cord-271526-14nfqusv 204 6 , , , cord-271526-14nfqusv 204 7 1997 1997 CD cord-271526-14nfqusv 204 8 ) ) -RRB- cord-271526-14nfqusv 204 9 . . . cord-271526-14nfqusv 205 1 Although although IN cord-271526-14nfqusv 205 2 it -PRON- PRP cord-271526-14nfqusv 205 3 is be VBZ cord-271526-14nfqusv 205 4 not not RB cord-271526-14nfqusv 205 5 known know VBN cord-271526-14nfqusv 205 6 whether whether IN cord-271526-14nfqusv 205 7 this this DT cord-271526-14nfqusv 205 8 encapsidation encapsidation NN cord-271526-14nfqusv 205 9 was be VBD cord-271526-14nfqusv 205 10 efficient efficient JJ cord-271526-14nfqusv 205 11 , , , cord-271526-14nfqusv 205 12 it -PRON- PRP cord-271526-14nfqusv 205 13 might may MD cord-271526-14nfqusv 205 14 be be VB cord-271526-14nfqusv 205 15 possible possible JJ cord-271526-14nfqusv 205 16 that that IN cord-271526-14nfqusv 205 17 interaction interaction NN cord-271526-14nfqusv 205 18 the the DT cord-271526-14nfqusv 205 19 heterologous heterologous JJ cord-271526-14nfqusv 205 20 flanking flanking JJ cord-271526-14nfqusv 205 21 sequences sequence NNS cord-271526-14nfqusv 205 22 have have VBP cord-271526-14nfqusv 205 23 increased increase VBN cord-271526-14nfqusv 205 24 the the DT cord-271526-14nfqusv 205 25 The the DT cord-271526-14nfqusv 205 26 N N NNP cord-271526-14nfqusv 205 27 - - HYPH cord-271526-14nfqusv 205 28 protein protein NN cord-271526-14nfqusv 205 29 of of IN cord-271526-14nfqusv 205 30 MHV MHV NNP cord-271526-14nfqusv 205 31 does do VBZ cord-271526-14nfqusv 205 32 not not RB cord-271526-14nfqusv 205 33 posess posess VB cord-271526-14nfqusv 205 34 any any DT cord-271526-14nfqusv 205 35 well well RB cord-271526-14nfqusv 205 36 known know VBN cord-271526-14nfqusv 205 37 flexibility flexibility NN cord-271526-14nfqusv 205 38 of of IN cord-271526-14nfqusv 205 39 the the DT cord-271526-14nfqusv 205 40 RNA RNA NNP cord-271526-14nfqusv 205 41 molecule molecule NN cord-271526-14nfqusv 205 42 , , , cord-271526-14nfqusv 205 43 allowing allow VBG cord-271526-14nfqusv 205 44 it -PRON- PRP cord-271526-14nfqusv 205 45 to to TO cord-271526-14nfqusv 205 46 adapt adapt VB cord-271526-14nfqusv 205 47 the the DT cord-271526-14nfqusv 205 48 RNA RNA NNP cord-271526-14nfqusv 205 49 binding binding NN cord-271526-14nfqusv 205 50 domains domain NNS cord-271526-14nfqusv 205 51 , , , cord-271526-14nfqusv 205 52 such such JJ cord-271526-14nfqusv 205 53 as as IN cord-271526-14nfqusv 205 54 the the DT cord-271526-14nfqusv 205 55 ARM arm NN cord-271526-14nfqusv 206 1 ( ( -LRB- cord-271526-14nfqusv 206 2 Lazinski Lazinski NNP cord-271526-14nfqusv 206 3 et et NNP cord-271526-14nfqusv 206 4 al al NNP cord-271526-14nfqusv 206 5 . . . cord-271526-14nfqusv 207 1 , , , cord-271526-14nfqusv 207 2 proper proper JJ cord-271526-14nfqusv 207 3 structure structure NN cord-271526-14nfqusv 207 4 for for IN cord-271526-14nfqusv 207 5 encapsidation encapsidation NN cord-271526-14nfqusv 207 6 . . . cord-271526-14nfqusv 208 1 1989 1989 CD cord-271526-14nfqusv 208 2 ; ; : cord-271526-14nfqusv 208 3 Talbot Talbot NNP cord-271526-14nfqusv 208 4 and and CC cord-271526-14nfqusv 208 5 Buchmeier Buchmeier NNP cord-271526-14nfqusv 208 6 , , , cord-271526-14nfqusv 208 7 1985 1985 CD cord-271526-14nfqusv 208 8 ) ) -RRB- cord-271526-14nfqusv 208 9 or or CC cord-271526-14nfqusv 208 10 zinc zinc NN cord-271526-14nfqusv 208 11 fingers finger NNS cord-271526-14nfqusv 208 12 ( ( -LRB- cord-271526-14nfqusv 208 13 Draper Draper NNP cord-271526-14nfqusv 208 14 , , , cord-271526-14nfqusv 208 15 1995 1995 CD cord-271526-14nfqusv 208 16 ) ) -RRB- cord-271526-14nfqusv 208 17 . . . cord-271526-14nfqusv 209 1 It -PRON- PRP cord-271526-14nfqusv 209 2 interacts interact VBZ cord-271526-14nfqusv 209 3 , , , cord-271526-14nfqusv 209 4 although although IN cord-271526-14nfqusv 209 5 , , , cord-271526-14nfqusv 209 6 specifically specifically RB cord-271526-14nfqusv 209 7 with with IN cord-271526-14nfqusv 209 8 Significance significance NN cord-271526-14nfqusv 209 9 of of IN cord-271526-14nfqusv 209 10 the the DT cord-271526-14nfqusv 209 11 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 209 12 protein protein NN cord-271526-14nfqusv 209 13 - - HYPH cord-271526-14nfqusv 209 14 Ps Ps NNP cord-271526-14nfqusv 209 15 RNA RNA NNP cord-271526-14nfqusv 209 16 leader leader NN cord-271526-14nfqusv 209 17 - - HYPH cord-271526-14nfqusv 209 18 RNA RNA NNP cord-271526-14nfqusv 209 19 ( ( -LRB- cord-271526-14nfqusv 209 20 Stohlman Stohlman NNP cord-271526-14nfqusv 209 21 et et NNP cord-271526-14nfqusv 209 22 al al NNP cord-271526-14nfqusv 209 23 . . NNP cord-271526-14nfqusv 209 24 , , , cord-271526-14nfqusv 209 25 1988 1988 CD cord-271526-14nfqusv 209 26 ; ; : cord-271526-14nfqusv 209 27 Baric Baric NNP cord-271526-14nfqusv 209 28 et et NNP cord-271526-14nfqusv 209 29 al al NNP cord-271526-14nfqusv 209 30 . . NNP cord-271526-14nfqusv 209 31 , , , cord-271526-14nfqusv 209 32 1988 1988 CD cord-271526-14nfqusv 209 33 ) ) -RRB- cord-271526-14nfqusv 209 34 and and CC cord-271526-14nfqusv 209 35 interaction interaction NN cord-271526-14nfqusv 209 36 an an DT cord-271526-14nfqusv 209 37 RNA RNA NNP cord-271526-14nfqusv 209 38 binding binding NN cord-271526-14nfqusv 209 39 domain domain NN cord-271526-14nfqusv 209 40 has have VBZ cord-271526-14nfqusv 209 41 been be VBN cord-271526-14nfqusv 209 42 identified identify VBN cord-271526-14nfqusv 209 43 ( ( -LRB- cord-271526-14nfqusv 210 1 Nelson Nelson NNP cord-271526-14nfqusv 210 2 and and CC cord-271526-14nfqusv 210 3 Stohlman Stohlman NNP cord-271526-14nfqusv 210 4 , , , cord-271526-14nfqusv 210 5 1993 1993 CD cord-271526-14nfqusv 210 6 ) ) -RRB- cord-271526-14nfqusv 210 7 . . . cord-271526-14nfqusv 211 1 This this DT cord-271526-14nfqusv 211 2 domain domain NN cord-271526-14nfqusv 211 3 comprises comprise VBZ cord-271526-14nfqusv 211 4 the the DT cord-271526-14nfqusv 211 5 two two CD cord-271526-14nfqusv 211 6 major major NN cord-271526-14nfqusv 211 7 Since since IN cord-271526-14nfqusv 211 8 MHV MHV NNP cord-271526-14nfqusv 211 9 virions virion NNS cord-271526-14nfqusv 211 10 contain contain VBP cord-271526-14nfqusv 211 11 only only RB cord-271526-14nfqusv 211 12 MHV MHV NNP cord-271526-14nfqusv 211 13 genomic genomic JJ cord-271526-14nfqusv 211 14 RNA rna NN cord-271526-14nfqusv 211 15 , , , cord-271526-14nfqusv 211 16 it -PRON- PRP cord-271526-14nfqusv 211 17 hydrophobic hydrophobic JJ cord-271526-14nfqusv 211 18 basic basic JJ cord-271526-14nfqusv 211 19 regions region NNS cord-271526-14nfqusv 211 20 in in IN cord-271526-14nfqusv 211 21 the the DT cord-271526-14nfqusv 211 22 middle middle NN cord-271526-14nfqusv 211 23 of of IN cord-271526-14nfqusv 211 24 the the DT cord-271526-14nfqusv 211 25 protein protein NN cord-271526-14nfqusv 211 26 . . . cord-271526-14nfqusv 212 1 is be VBZ cord-271526-14nfqusv 212 2 evident evident JJ cord-271526-14nfqusv 212 3 that that IN cord-271526-14nfqusv 212 4 RNA RNA NNP cord-271526-14nfqusv 212 5 encapsidation encapsidation NN cord-271526-14nfqusv 212 6 is be VBZ cord-271526-14nfqusv 212 7 a a DT cord-271526-14nfqusv 212 8 highly highly RB cord-271526-14nfqusv 212 9 specific specific JJ cord-271526-14nfqusv 212 10 Since since IN cord-271526-14nfqusv 212 11 this this DT cord-271526-14nfqusv 212 12 central central JJ cord-271526-14nfqusv 212 13 part part NN cord-271526-14nfqusv 212 14 of of IN cord-271526-14nfqusv 212 15 the the DT cord-271526-14nfqusv 212 16 N N NNP cord-271526-14nfqusv 212 17 protein protein NN cord-271526-14nfqusv 212 18 contains contain VBZ cord-271526-14nfqusv 212 19 a a DT cord-271526-14nfqusv 212 20 high high JJ cord-271526-14nfqusv 212 21 process process NN cord-271526-14nfqusv 212 22 . . . cord-271526-14nfqusv 213 1 The the DT cord-271526-14nfqusv 213 2 location location NN cord-271526-14nfqusv 213 3 of of IN cord-271526-14nfqusv 213 4 the the DT cord-271526-14nfqusv 213 5 encapsidation encapsidation NN cord-271526-14nfqusv 213 6 signal signal NN cord-271526-14nfqusv 213 7 in in IN cord-271526-14nfqusv 213 8 degree degree NN cord-271526-14nfqusv 213 9 of of IN cord-271526-14nfqusv 213 10 basic basic JJ cord-271526-14nfqusv 213 11 amino amino NN cord-271526-14nfqusv 213 12 acids acid NNS cord-271526-14nfqusv 213 13 , , , cord-271526-14nfqusv 213 14 it -PRON- PRP cord-271526-14nfqusv 213 15 is be VBZ cord-271526-14nfqusv 213 16 possible possible JJ cord-271526-14nfqusv 213 17 that that IN cord-271526-14nfqusv 213 18 the the DT cord-271526-14nfqusv 213 19 Ps Ps NNP cord-271526-14nfqusv 213 20 ORF1b ORF1b NNP cord-271526-14nfqusv 213 21 ensures ensure VBZ cord-271526-14nfqusv 213 22 the the DT cord-271526-14nfqusv 213 23 specific specific JJ cord-271526-14nfqusv 213 24 encapsidation encapsidation NN cord-271526-14nfqusv 213 25 of of IN cord-271526-14nfqusv 213 26 only only JJ cord-271526-14nfqusv 213 27 genorecognition genorecognition NN cord-271526-14nfqusv 213 28 domain domain NN cord-271526-14nfqusv 213 29 might may MD cord-271526-14nfqusv 213 30 also also RB cord-271526-14nfqusv 213 31 be be VB cord-271526-14nfqusv 213 32 positioned position VBN cord-271526-14nfqusv 213 33 somewhere somewhere RB cord-271526-14nfqusv 213 34 mic mic NN cord-271526-14nfqusv 213 35 RNA RNA NNP cord-271526-14nfqusv 213 36 . . . cord-271526-14nfqusv 214 1 It -PRON- PRP cord-271526-14nfqusv 214 2 is be VBZ cord-271526-14nfqusv 214 3 unclear unclear JJ cord-271526-14nfqusv 214 4 if if IN cord-271526-14nfqusv 214 5 the the DT cord-271526-14nfqusv 214 6 MHV MHV NNP cord-271526-14nfqusv 215 1 Ps ps NN cord-271526-14nfqusv 215 2 is be VBZ cord-271526-14nfqusv 215 3 by by IN cord-271526-14nfqusv 215 4 itself -PRON- PRP cord-271526-14nfqusv 215 5 sufficient sufficient JJ cord-271526-14nfqusv 215 6 within within IN cord-271526-14nfqusv 215 7 this this DT cord-271526-14nfqusv 215 8 part part NN cord-271526-14nfqusv 215 9 of of IN cord-271526-14nfqusv 215 10 the the DT cord-271526-14nfqusv 215 11 N N NNP cord-271526-14nfqusv 215 12 protein protein NN cord-271526-14nfqusv 215 13 . . . cord-271526-14nfqusv 216 1 for for IN cord-271526-14nfqusv 216 2 efficient efficient JJ cord-271526-14nfqusv 216 3 encapsidation encapsidation NN cord-271526-14nfqusv 216 4 . . . cord-271526-14nfqusv 217 1 It -PRON- PRP cord-271526-14nfqusv 217 2 is be VBZ cord-271526-14nfqusv 217 3 known know VBN cord-271526-14nfqusv 217 4 that that IN cord-271526-14nfqusv 217 5 Rous rous JJ cord-271526-14nfqusv 217 6 sarcoma sarcoma NN cord-271526-14nfqusv 218 1 In in IN cord-271526-14nfqusv 218 2 infected infected JJ cord-271526-14nfqusv 218 3 cells cell NNS cord-271526-14nfqusv 218 4 the the DT cord-271526-14nfqusv 218 5 N n CD cord-271526-14nfqusv 218 6 protein protein NN cord-271526-14nfqusv 218 7 of of IN cord-271526-14nfqusv 218 8 MHV MHV NNP cord-271526-14nfqusv 218 9 is be VBZ cord-271526-14nfqusv 218 10 very very RB cord-271526-14nfqusv 218 11 rapidly rapidly RB cord-271526-14nfqusv 219 1 virus virus NN cord-271526-14nfqusv 219 2 has have VBZ cord-271526-14nfqusv 219 3 multiple multiple JJ cord-271526-14nfqusv 219 4 encapsidation encapsidation NN cord-271526-14nfqusv 219 5 sites site NNS cord-271526-14nfqusv 219 6 , , , cord-271526-14nfqusv 219 7 which which WDT cord-271526-14nfqusv 219 8 are be VBP cord-271526-14nfqusv 219 9 rephosphorylated rephosphorylate VBN cord-271526-14nfqusv 219 10 on on IN cord-271526-14nfqusv 219 11 serine serine JJ cord-271526-14nfqusv 219 12 residues residue NNS cord-271526-14nfqusv 219 13 ( ( -LRB- cord-271526-14nfqusv 219 14 Stohlman Stohlman NNP cord-271526-14nfqusv 219 15 and and CC cord-271526-14nfqusv 219 16 Lai Lai NNP cord-271526-14nfqusv 219 17 , , , cord-271526-14nfqusv 219 18 quired quire VBN cord-271526-14nfqusv 219 19 to to TO cord-271526-14nfqusv 219 20 interact interact VB cord-271526-14nfqusv 219 21 for for IN cord-271526-14nfqusv 219 22 efficient efficient JJ cord-271526-14nfqusv 219 23 packaging packaging NN cord-271526-14nfqusv 219 24 of of IN cord-271526-14nfqusv 219 25 the the DT cord-271526-14nfqusv 219 26 genome genome NN cord-271526-14nfqusv 219 27 1979 1979 CD cord-271526-14nfqusv 219 28 ) ) -RRB- cord-271526-14nfqusv 219 29 and and CC cord-271526-14nfqusv 219 30 part part NN cord-271526-14nfqusv 219 31 of of IN cord-271526-14nfqusv 219 32 it -PRON- PRP cord-271526-14nfqusv 219 33 concomitantly concomitantly RB cord-271526-14nfqusv 219 34 becomes become VBZ cord-271526-14nfqusv 219 35 associated associate VBN cord-271526-14nfqusv 220 1 ( ( -LRB- cord-271526-14nfqusv 220 2 Sorge Sorge NNP cord-271526-14nfqusv 220 3 et et NNP cord-271526-14nfqusv 220 4 al al NNP cord-271526-14nfqusv 220 5 . . NNP cord-271526-14nfqusv 220 6 , , , cord-271526-14nfqusv 220 7 1983 1983 CD cord-271526-14nfqusv 220 8 ; ; . cord-271526-14nfqusv 221 1 Pugatsch Pugatsch NNP cord-271526-14nfqusv 221 2 and and CC cord-271526-14nfqusv 221 3 Stacey Stacey NNP cord-271526-14nfqusv 221 4 , , , cord-271526-14nfqusv 221 5 1983 1983 CD cord-271526-14nfqusv 221 6 ) ) -RRB- cord-271526-14nfqusv 221 7 . . . cord-271526-14nfqusv 222 1 Recently recently RB cord-271526-14nfqusv 222 2 , , , cord-271526-14nfqusv 222 3 with with IN cord-271526-14nfqusv 222 4 a a DT cord-271526-14nfqusv 222 5 cell cell NN cord-271526-14nfqusv 222 6 membrane membrane NN cord-271526-14nfqusv 222 7 fraction fraction NN cord-271526-14nfqusv 223 1 ( ( -LRB- cord-271526-14nfqusv 223 2 Stohlman Stohlman NNP cord-271526-14nfqusv 223 3 et et NNP cord-271526-14nfqusv 223 4 al al NNP cord-271526-14nfqusv 223 5 . . . cord-271526-14nfqusv 224 1 , , , cord-271526-14nfqusv 224 2 1983 1983 CD cord-271526-14nfqusv 224 3 ; ; : cord-271526-14nfqusv 224 4 _SP cord-271526-14nfqusv 224 5 it -PRON- PRP cord-271526-14nfqusv 224 6 was be VBD cord-271526-14nfqusv 224 7 shown show VBN cord-271526-14nfqusv 224 8 that that IN cord-271526-14nfqusv 224 9 a a DT cord-271526-14nfqusv 224 10 subgenomic subgenomic NNP cord-271526-14nfqusv 224 11 RNA RNA NNP cord-271526-14nfqusv 224 12 of of IN cord-271526-14nfqusv 224 13 MHV MHV NNP cord-271526-14nfqusv 224 14 containing contain VBG cord-271526-14nfqusv 224 15 Anderson Anderson NNP cord-271526-14nfqusv 224 16 and and CC cord-271526-14nfqusv 224 17 Wong Wong NNP cord-271526-14nfqusv 224 18 , , , cord-271526-14nfqusv 224 19 1993 1993 CD cord-271526-14nfqusv 224 20 ) ) -RRB- cord-271526-14nfqusv 224 21 . . . cord-271526-14nfqusv 225 1 It -PRON- PRP cord-271526-14nfqusv 225 2 is be VBZ cord-271526-14nfqusv 225 3 still still RB cord-271526-14nfqusv 225 4 unknown unknown JJ cord-271526-14nfqusv 225 5 if if IN cord-271526-14nfqusv 225 6 phosthe phosthe DT cord-271526-14nfqusv 225 7 Ps Ps NNP cord-271526-14nfqusv 225 8 can can MD cord-271526-14nfqusv 225 9 be be VB cord-271526-14nfqusv 225 10 encapsidated encapsidate VBN cord-271526-14nfqusv 225 11 specifically specifically RB cord-271526-14nfqusv 225 12 but but CC cord-271526-14nfqusv 225 13 the the DT cord-271526-14nfqusv 225 14 efficiency efficiency NN cord-271526-14nfqusv 225 15 phorylation phorylation NN cord-271526-14nfqusv 225 16 is be VBZ cord-271526-14nfqusv 225 17 carried carry VBN cord-271526-14nfqusv 225 18 out out RP cord-271526-14nfqusv 225 19 by by IN cord-271526-14nfqusv 225 20 a a DT cord-271526-14nfqusv 225 21 host host NN cord-271526-14nfqusv 225 22 cell cell NN cord-271526-14nfqusv 225 23 or or CC cord-271526-14nfqusv 225 24 viral viral JJ cord-271526-14nfqusv 225 25 encoded encode VBN cord-271526-14nfqusv 225 26 was be VBD cord-271526-14nfqusv 225 27 much much RB cord-271526-14nfqusv 225 28 lower low JJR cord-271526-14nfqusv 225 29 as as IN cord-271526-14nfqusv 225 30 compared compare VBN cord-271526-14nfqusv 225 31 to to IN cord-271526-14nfqusv 225 32 the the DT cord-271526-14nfqusv 225 33 encapsidation encapsidation NN cord-271526-14nfqusv 225 34 effiprotein effiprotein NNP cord-271526-14nfqusv 225 35 kinase kinase VBZ cord-271526-14nfqusv 225 36 and and CC cord-271526-14nfqusv 225 37 its -PRON- PRP$ cord-271526-14nfqusv 225 38 ( ( -LRB- cord-271526-14nfqusv 225 39 biological biological JJ cord-271526-14nfqusv 225 40 ) ) -RRB- cord-271526-14nfqusv 225 41 role role NN cord-271526-14nfqusv 225 42 remains remain VBZ cord-271526-14nfqusv 225 43 unclear unclear JJ cord-271526-14nfqusv 225 44 . . . cord-271526-14nfqusv 226 1 ciency ciency NNP cord-271526-14nfqusv 226 2 of of IN cord-271526-14nfqusv 226 3 a a DT cord-271526-14nfqusv 226 4 defective defective JJ cord-271526-14nfqusv 226 5 interfering interfere VBG cord-271526-14nfqusv 226 6 RNA RNA NNP cord-271526-14nfqusv 226 7 ( ( -LRB- cord-271526-14nfqusv 226 8 Bos Bos NNP cord-271526-14nfqusv 226 9 et et NNP cord-271526-14nfqusv 226 10 al al NNP cord-271526-14nfqusv 226 11 . . NNP cord-271526-14nfqusv 226 12 , , , cord-271526-14nfqusv 226 13 1997 1997 CD cord-271526-14nfqusv 226 14 ) ) -RRB- cord-271526-14nfqusv 226 15 . . . cord-271526-14nfqusv 227 1 It -PRON- PRP cord-271526-14nfqusv 227 2 has have VBZ cord-271526-14nfqusv 227 3 been be VBN cord-271526-14nfqusv 227 4 suggested suggest VBN cord-271526-14nfqusv 227 5 that that IN cord-271526-14nfqusv 227 6 it -PRON- PRP cord-271526-14nfqusv 227 7 might may MD cord-271526-14nfqusv 227 8 govern govern VB cord-271526-14nfqusv 227 9 the the DT cord-271526-14nfqusv 227 10 tightness tightness NN cord-271526-14nfqusv 228 1 Preassembled Preassembled NNP cord-271526-14nfqusv 228 2 nucleocapsids nucleocapsid NNS cord-271526-14nfqusv 228 3 have have VBP cord-271526-14nfqusv 228 4 never never RB cord-271526-14nfqusv 228 5 been be VBN cord-271526-14nfqusv 228 6 obof obof VB cord-271526-14nfqusv 228 7 the the DT cord-271526-14nfqusv 228 8 interaction interaction NN cord-271526-14nfqusv 228 9 between between IN cord-271526-14nfqusv 228 10 N N NNP cord-271526-14nfqusv 228 11 and and CC cord-271526-14nfqusv 228 12 RNA RNA NNP cord-271526-14nfqusv 228 13 ( ( -LRB- cord-271526-14nfqusv 228 14 Laude Laude NNP cord-271526-14nfqusv 228 15 and and CC cord-271526-14nfqusv 228 16 Masserved Masserved NNP cord-271526-14nfqusv 228 17 in in IN cord-271526-14nfqusv 228 18 coronavirus coronavirus NN cord-271526-14nfqusv 228 19 infected infect VBN cord-271526-14nfqusv 228 20 cells cell NNS cord-271526-14nfqusv 228 21 , , , cord-271526-14nfqusv 228 22 but but CC cord-271526-14nfqusv 228 23 an an DT cord-271526-14nfqusv 228 24 electronters electronter NNS cord-271526-14nfqusv 228 25 , , , cord-271526-14nfqusv 228 26 1995 1995 CD cord-271526-14nfqusv 228 27 ) ) -RRB- cord-271526-14nfqusv 228 28 . . . cord-271526-14nfqusv 229 1 It -PRON- PRP cord-271526-14nfqusv 229 2 will will MD cord-271526-14nfqusv 229 3 be be VB cord-271526-14nfqusv 229 4 interesting interesting JJ cord-271526-14nfqusv 229 5 to to TO cord-271526-14nfqusv 229 6 compare compare VB cord-271526-14nfqusv 229 7 the the DT cord-271526-14nfqusv 229 8 phosphordense phosphordense NNP cord-271526-14nfqusv 229 9 structure structure NN cord-271526-14nfqusv 229 10 , , , cord-271526-14nfqusv 229 11 which which WDT cord-271526-14nfqusv 229 12 may may MD cord-271526-14nfqusv 229 13 correspond correspond VB cord-271526-14nfqusv 229 14 to to IN cord-271526-14nfqusv 229 15 the the DT cord-271526-14nfqusv 229 16 nucleoylation nucleoylation NN cord-271526-14nfqusv 229 17 of of IN cord-271526-14nfqusv 229 18 the the DT cord-271526-14nfqusv 229 19 N n CD cord-271526-14nfqusv 229 20 protein protein NN cord-271526-14nfqusv 229 21 from from IN cord-271526-14nfqusv 229 22 infected infected JJ cord-271526-14nfqusv 229 23 cells cell NNS cord-271526-14nfqusv 229 24 and and CC cord-271526-14nfqusv 229 25 the the DT cord-271526-14nfqusv 229 26 recomcapsid recomcapsid NN cord-271526-14nfqusv 229 27 , , , cord-271526-14nfqusv 229 28 can can MD cord-271526-14nfqusv 229 29 be be VB cord-271526-14nfqusv 229 30 found find VBN cord-271526-14nfqusv 229 31 at at IN cord-271526-14nfqusv 229 32 the the DT cord-271526-14nfqusv 229 33 cytoplasmic cytoplasmic JJ cord-271526-14nfqusv 229 34 face face NN cord-271526-14nfqusv 229 35 of of IN cord-271526-14nfqusv 229 36 the the DT cord-271526-14nfqusv 229 37 binant binant JJ cord-271526-14nfqusv 229 38 N N NNP cord-271526-14nfqusv 229 39 protein protein NN cord-271526-14nfqusv 229 40 and and CC cord-271526-14nfqusv 229 41 to to TO cord-271526-14nfqusv 229 42 investigate investigate VB cord-271526-14nfqusv 229 43 the the DT cord-271526-14nfqusv 229 44 possible possible JJ cord-271526-14nfqusv 229 45 role role NN cord-271526-14nfqusv 229 46 of of IN cord-271526-14nfqusv 229 47 budding bud VBG cord-271526-14nfqusv 229 48 site site NN cord-271526-14nfqusv 229 49 ( ( -LRB- cord-271526-14nfqusv 229 50 Dubois Dubois NNP cord-271526-14nfqusv 229 51 - - HYPH cord-271526-14nfqusv 229 52 Dalcq Dalcq NNP cord-271526-14nfqusv 229 53 et et NNP cord-271526-14nfqusv 229 54 al al NNP cord-271526-14nfqusv 229 55 . . NNP cord-271526-14nfqusv 229 56 , , , cord-271526-14nfqusv 229 57 1982 1982 CD cord-271526-14nfqusv 229 58 ; ; : cord-271526-14nfqusv 229 59 Holmes Holmes NNP cord-271526-14nfqusv 229 60 , , , cord-271526-14nfqusv 229 61 1991 1991 CD cord-271526-14nfqusv 229 62 ) ) -RRB- cord-271526-14nfqusv 229 63 . . . cord-271526-14nfqusv 230 1 phosphorylation phosphorylation NN cord-271526-14nfqusv 230 2 in in IN cord-271526-14nfqusv 230 3 RNA RNA NNP cord-271526-14nfqusv 230 4 binding binding NN cord-271526-14nfqusv 230 5 . . . cord-271526-14nfqusv 231 1 Phosphorylation Phosphorylation NNP cord-271526-14nfqusv 231 2 and and CC cord-271526-14nfqusv 231 3 Nucleocapsid Nucleocapsid NNP cord-271526-14nfqusv 231 4 incorporation incorporation NN cord-271526-14nfqusv 231 5 in in IN cord-271526-14nfqusv 231 6 budding bud VBG cord-271526-14nfqusv 231 7 virions virion NNS cord-271526-14nfqusv 231 8 is be VBZ cord-271526-14nfqusv 231 9 exlikewise exlikewise NN cord-271526-14nfqusv 231 10 dephosphorylation dephosphorylation NN cord-271526-14nfqusv 231 11 could could MD cord-271526-14nfqusv 231 12 also also RB cord-271526-14nfqusv 231 13 induce induce VB cord-271526-14nfqusv 231 14 a a DT cord-271526-14nfqusv 231 15 major major JJ cord-271526-14nfqusv 231 16 pected pected NN cord-271526-14nfqusv 231 17 to to TO cord-271526-14nfqusv 231 18 be be VB cord-271526-14nfqusv 231 19 mediated mediate VBN cord-271526-14nfqusv 231 20 by by IN cord-271526-14nfqusv 231 21 M M NNP cord-271526-14nfqusv 231 22 - - HYPH cord-271526-14nfqusv 231 23 N N NNP cord-271526-14nfqusv 231 24 protein protein NN cord-271526-14nfqusv 231 25 interactions interaction NNS cord-271526-14nfqusv 231 26 . . . cord-271526-14nfqusv 232 1 Asconformational Asconformational NNP cord-271526-14nfqusv 232 2 change change NN cord-271526-14nfqusv 232 3 of of IN cord-271526-14nfqusv 232 4 the the DT cord-271526-14nfqusv 232 5 N N NNP cord-271526-14nfqusv 232 6 protein protein NN cord-271526-14nfqusv 232 7 . . . cord-271526-14nfqusv 233 1 It -PRON- PRP cord-271526-14nfqusv 233 2 has have VBZ cord-271526-14nfqusv 233 3 been be VBN cord-271526-14nfqusv 233 4 sugsociation sugsociation NN cord-271526-14nfqusv 233 5 of of IN cord-271526-14nfqusv 233 6 the the DT cord-271526-14nfqusv 233 7 M M NNP cord-271526-14nfqusv 233 8 protein protein NN cord-271526-14nfqusv 233 9 to to IN cord-271526-14nfqusv 233 10 the the DT cord-271526-14nfqusv 233 11 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 233 12 in in IN cord-271526-14nfqusv 233 13 NP-40gested NP-40gested NNP cord-271526-14nfqusv 233 14 that that IN cord-271526-14nfqusv 233 15 dephosphorylation dephosphorylation NN cord-271526-14nfqusv 233 16 of of IN cord-271526-14nfqusv 233 17 the the DT cord-271526-14nfqusv 233 18 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 233 19 after after IN cord-271526-14nfqusv 233 20 disrupted disrupt VBN cord-271526-14nfqusv 233 21 virions virion NNS cord-271526-14nfqusv 233 22 has have VBZ cord-271526-14nfqusv 233 23 been be VBN cord-271526-14nfqusv 233 24 reported report VBN cord-271526-14nfqusv 234 1 ( ( -LRB- cord-271526-14nfqusv 234 2 Sturman Sturman NNP cord-271526-14nfqusv 234 3 et et NNP cord-271526-14nfqusv 234 4 al al NNP cord-271526-14nfqusv 234 5 . . . cord-271526-14nfqusv 235 1 , , , cord-271526-14nfqusv 235 2 virus virus NN cord-271526-14nfqusv 235 3 entry entry NN cord-271526-14nfqusv 235 4 is be VBZ cord-271526-14nfqusv 235 5 involved involve VBN cord-271526-14nfqusv 235 6 in in IN cord-271526-14nfqusv 235 7 uncoating uncoating NN cord-271526-14nfqusv 235 8 of of IN cord-271526-14nfqusv 235 9 the the DT cord-271526-14nfqusv 235 10 viral viral JJ cord-271526-14nfqusv 235 11 RNA RNA NNP cord-271526-14nfqusv 235 12 ( ( -LRB- cord-271526-14nfqusv 235 13 Ma-1980 Ma-1980 NNP cord-271526-14nfqusv 235 14 ) ) -RRB- cord-271526-14nfqusv 235 15 ; ; : cord-271526-14nfqusv 235 16 however however RB cord-271526-14nfqusv 235 17 , , , cord-271526-14nfqusv 235 18 the the DT cord-271526-14nfqusv 235 19 same same JJ cord-271526-14nfqusv 235 20 study study NN cord-271526-14nfqusv 235 21 demonstrated demonstrate VBD cord-271526-14nfqusv 235 22 that that IN cord-271526-14nfqusv 235 23 the the DT cord-271526-14nfqusv 235 24 hondas hondas NNPS cord-271526-14nfqusv 235 25 and and CC cord-271526-14nfqusv 235 26 Dales Dales NNPS cord-271526-14nfqusv 235 27 , , , cord-271526-14nfqusv 235 28 1991 1991 CD cord-271526-14nfqusv 235 29 ) ) -RRB- cord-271526-14nfqusv 235 30 . . . cord-271526-14nfqusv 236 1 M M NNP cord-271526-14nfqusv 236 2 protein protein NN cord-271526-14nfqusv 236 3 was be VBD cord-271526-14nfqusv 236 4 able able JJ cord-271526-14nfqusv 236 5 to to TO cord-271526-14nfqusv 236 6 bind bind VB cord-271526-14nfqusv 236 7 RNA RNA NNP cord-271526-14nfqusv 236 8 in in IN cord-271526-14nfqusv 236 9 the the DT cord-271526-14nfqusv 236 10 absence absence NN cord-271526-14nfqusv 236 11 of of IN cord-271526-14nfqusv 236 12 N. n. NN cord-271526-14nfqusv 236 13 It -PRON- PRP cord-271526-14nfqusv 237 1 In in IN cord-271526-14nfqusv 237 2 general general JJ cord-271526-14nfqusv 237 3 the the DT cord-271526-14nfqusv 237 4 recognition recognition NN cord-271526-14nfqusv 237 5 of of IN cord-271526-14nfqusv 237 6 an an DT cord-271526-14nfqusv 237 7 RNA RNA NNP cord-271526-14nfqusv 237 8 signal signal NN cord-271526-14nfqusv 237 9 by by IN cord-271526-14nfqusv 237 10 a a DT cord-271526-14nfqusv 237 11 protein protein NN cord-271526-14nfqusv 237 12 is be VBZ cord-271526-14nfqusv 237 13 still still RB cord-271526-14nfqusv 237 14 unclear unclear JJ cord-271526-14nfqusv 237 15 if if IN cord-271526-14nfqusv 237 16 the the DT cord-271526-14nfqusv 237 17 interaction interaction NN cord-271526-14nfqusv 237 18 between between IN cord-271526-14nfqusv 237 19 M M NNP cord-271526-14nfqusv 237 20 and and CC cord-271526-14nfqusv 237 21 N N NNP cord-271526-14nfqusv 237 22 is be VBZ cord-271526-14nfqusv 237 23 a a DT cord-271526-14nfqusv 237 24 involves involve VBZ cord-271526-14nfqusv 237 25 secondary secondary JJ cord-271526-14nfqusv 237 26 structure structure NN cord-271526-14nfqusv 237 27 elements element NNS cord-271526-14nfqusv 237 28 in in IN cord-271526-14nfqusv 237 29 addition addition NN cord-271526-14nfqusv 237 30 to to IN cord-271526-14nfqusv 237 31 the the DT cord-271526-14nfqusv 237 32 prerequisite prerequisite NN cord-271526-14nfqusv 237 33 for for IN cord-271526-14nfqusv 237 34 RNA RNA NNP cord-271526-14nfqusv 237 35 encapsidation encapsidation NN cord-271526-14nfqusv 237 36 in in IN cord-271526-14nfqusv 237 37 vivo vivo NNP cord-271526-14nfqusv 237 38 . . . cord-271526-14nfqusv 238 1 This this DT cord-271526-14nfqusv 238 2 interacprimary interacprimary JJ cord-271526-14nfqusv 238 3 sequence sequence NN cord-271526-14nfqusv 238 4 of of IN cord-271526-14nfqusv 238 5 the the DT cord-271526-14nfqusv 238 6 RNA RNA NNP cord-271526-14nfqusv 238 7 signal signal NN cord-271526-14nfqusv 238 8 ( ( -LRB- cord-271526-14nfqusv 238 9 Draper Draper NNP cord-271526-14nfqusv 238 10 , , , cord-271526-14nfqusv 238 11 1995 1995 CD cord-271526-14nfqusv 238 12 ) ) -RRB- cord-271526-14nfqusv 238 13 . . . cord-271526-14nfqusv 239 1 tion tion NN cord-271526-14nfqusv 239 2 could could MD cord-271526-14nfqusv 239 3 position position VB cord-271526-14nfqusv 239 4 the the DT cord-271526-14nfqusv 239 5 N n CD cord-271526-14nfqusv 239 6 protein protein NN cord-271526-14nfqusv 239 7 in in IN cord-271526-14nfqusv 239 8 a a DT cord-271526-14nfqusv 239 9 favorable favorable JJ cord-271526-14nfqusv 239 10 way way NN cord-271526-14nfqusv 239 11 to to IN cord-271526-14nfqusv 239 12 There there EX cord-271526-14nfqusv 239 13 is be VBZ cord-271526-14nfqusv 239 14 accumulating accumulate VBG cord-271526-14nfqusv 239 15 evidence evidence NN cord-271526-14nfqusv 239 16 for for IN cord-271526-14nfqusv 239 17 an an DT cord-271526-14nfqusv 239 18 induced induce VBN cord-271526-14nfqusv 239 19 - - HYPH cord-271526-14nfqusv 239 20 fit fit JJ cord-271526-14nfqusv 239 21 mechinteract mechinteract NN cord-271526-14nfqusv 239 22 with with IN cord-271526-14nfqusv 239 23 the the DT cord-271526-14nfqusv 239 24 genomic genomic JJ cord-271526-14nfqusv 239 25 RNA rna NN cord-271526-14nfqusv 239 26 . . . cord-271526-14nfqusv 240 1 This this DT cord-271526-14nfqusv 240 2 must must MD cord-271526-14nfqusv 240 3 then then RB cord-271526-14nfqusv 240 4 be be VB cord-271526-14nfqusv 240 5 folanism folanism NN cord-271526-14nfqusv 240 6 in in IN cord-271526-14nfqusv 240 7 RNA RNA NNP cord-271526-14nfqusv 240 8 - - HYPH cord-271526-14nfqusv 240 9 protein protein NN cord-271526-14nfqusv 240 10 interactions interaction NNS cord-271526-14nfqusv 240 11 affecting affect VBG cord-271526-14nfqusv 240 12 both both CC cord-271526-14nfqusv 240 13 the the DT cord-271526-14nfqusv 240 14 lowed lowed NN cord-271526-14nfqusv 240 15 by by IN cord-271526-14nfqusv 240 16 interaction interaction NN cord-271526-14nfqusv 240 17 with with IN cord-271526-14nfqusv 240 18 additional additional JJ cord-271526-14nfqusv 240 19 N n CD cord-271526-14nfqusv 240 20 proteins protein NNS cord-271526-14nfqusv 240 21 , , , cord-271526-14nfqusv 240 22 forming form VBG cord-271526-14nfqusv 240 23 RNA RNA NNP cord-271526-14nfqusv 240 24 and and CC cord-271526-14nfqusv 240 25 the the DT cord-271526-14nfqusv 240 26 protein protein NN cord-271526-14nfqusv 240 27 ( ( -LRB- cord-271526-14nfqusv 240 28 Beck Beck NNP cord-271526-14nfqusv 240 29 and and CC cord-271526-14nfqusv 240 30 Nassal Nassal NNP cord-271526-14nfqusv 240 31 , , , cord-271526-14nfqusv 240 32 1997 1997 CD cord-271526-14nfqusv 240 33 ; ; : cord-271526-14nfqusv 240 34 Allain Allain NNP cord-271526-14nfqusv 240 35 et et NNP cord-271526-14nfqusv 240 36 the the DT cord-271526-14nfqusv 240 37 helical helical JJ cord-271526-14nfqusv 240 38 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 240 39 . . . cord-271526-14nfqusv 241 1 Involvement involvement NN cord-271526-14nfqusv 241 2 of of IN cord-271526-14nfqusv 241 3 other other JJ cord-271526-14nfqusv 241 4 viral viral JJ cord-271526-14nfqusv 241 5 proal proal NN cord-271526-14nfqusv 241 6 . . . cord-271526-14nfqusv 242 1 , , , cord-271526-14nfqusv 242 2 1996 1996 CD cord-271526-14nfqusv 242 3 ) ) -RRB- cord-271526-14nfqusv 242 4 . . . cord-271526-14nfqusv 243 1 Sufficient sufficient JJ cord-271526-14nfqusv 243 2 flexibility flexibility NN cord-271526-14nfqusv 243 3 in in IN cord-271526-14nfqusv 243 4 the the DT cord-271526-14nfqusv 243 5 RNA RNA NNP cord-271526-14nfqusv 243 6 molecule molecule NN cord-271526-14nfqusv 243 7 could could MD cord-271526-14nfqusv 243 8 teins tein VBZ cord-271526-14nfqusv 243 9 in in IN cord-271526-14nfqusv 243 10 Ps Ps NNP cord-271526-14nfqusv 243 11 RNA RNA NNP cord-271526-14nfqusv 243 12 binding binding NN cord-271526-14nfqusv 243 13 , , , cord-271526-14nfqusv 243 14 however however RB cord-271526-14nfqusv 243 15 , , , cord-271526-14nfqusv 243 16 was be VBD cord-271526-14nfqusv 243 17 not not RB cord-271526-14nfqusv 243 18 observed observe VBN cord-271526-14nfqusv 243 19 in in IN cord-271526-14nfqusv 243 20 be be VB cord-271526-14nfqusv 243 21 a a DT cord-271526-14nfqusv 243 22 major major JJ cord-271526-14nfqusv 243 23 determinant determinant NN cord-271526-14nfqusv 243 24 in in IN cord-271526-14nfqusv 243 25 protein protein NN cord-271526-14nfqusv 243 26 binding binding NN cord-271526-14nfqusv 243 27 . . . cord-271526-14nfqusv 244 1 From from IN cord-271526-14nfqusv 244 2 that that DT cord-271526-14nfqusv 244 3 our -PRON- PRP$ cord-271526-14nfqusv 244 4 in in FW cord-271526-14nfqusv 244 5 vitro vitro FW cord-271526-14nfqusv 244 6 studies study NNS cord-271526-14nfqusv 244 7 . . . cord-271526-14nfqusv 245 1 Recombinant recombinant JJ cord-271526-14nfqusv 245 2 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 245 3 protein protein NN cord-271526-14nfqusv 245 4 , , , cord-271526-14nfqusv 245 5 perspective perspective NN cord-271526-14nfqusv 245 6 , , , cord-271526-14nfqusv 245 7 the the DT cord-271526-14nfqusv 245 8 recognition recognition NN cord-271526-14nfqusv 245 9 of of IN cord-271526-14nfqusv 245 10 the the DT cord-271526-14nfqusv 245 11 Ps Ps NNP cord-271526-14nfqusv 245 12 by by IN cord-271526-14nfqusv 245 13 the the DT cord-271526-14nfqusv 245 14 N N NNP cord-271526-14nfqusv 245 15 protein protein NN cord-271526-14nfqusv 245 16 expressed express VBD cord-271526-14nfqusv 245 17 in in IN cord-271526-14nfqusv 245 18 the the DT cord-271526-14nfqusv 245 19 vTF7 vTF7 NNP cord-271526-14nfqusv 245 20 expression expression NN cord-271526-14nfqusv 245 21 system system NN cord-271526-14nfqusv 245 22 , , , cord-271526-14nfqusv 245 23 interacts interact VBZ cord-271526-14nfqusv 245 24 also also RB cord-271526-14nfqusv 245 25 could could MD cord-271526-14nfqusv 245 26 be be VB cord-271526-14nfqusv 245 27 highly highly RB cord-271526-14nfqusv 245 28 dependent dependent JJ cord-271526-14nfqusv 245 29 on on IN cord-271526-14nfqusv 245 30 the the DT cord-271526-14nfqusv 245 31 secondary secondary JJ cord-271526-14nfqusv 245 32 structure structure NN cord-271526-14nfqusv 245 33 specifically specifically RB cord-271526-14nfqusv 245 34 with with IN cord-271526-14nfqusv 245 35 the the DT cord-271526-14nfqusv 245 36 Ps Ps NNP cord-271526-14nfqusv 245 37 RNA RNA NNP cord-271526-14nfqusv 245 38 ( ( -LRB- cord-271526-14nfqusv 245 39 Fig Fig NNP cord-271526-14nfqusv 245 40 . . . cord-271526-14nfqusv 245 41 6C 6C NNP cord-271526-14nfqusv 245 42 ) ) -RRB- cord-271526-14nfqusv 245 43 , , , cord-271526-14nfqusv 245 44 although although IN cord-271526-14nfqusv 245 45 the the DT cord-271526-14nfqusv 245 46 effiof effiof NNP cord-271526-14nfqusv 245 47 the the DT cord-271526-14nfqusv 245 48 Ps Ps NNP cord-271526-14nfqusv 245 49 domain domain NN cord-271526-14nfqusv 245 50 . . . cord-271526-14nfqusv 246 1 When when WRB cord-271526-14nfqusv 246 2 a a DT cord-271526-14nfqusv 246 3 short short JJ cord-271526-14nfqusv 246 4 RNA RNA NNP cord-271526-14nfqusv 246 5 probe probe NN cord-271526-14nfqusv 246 6 consisting consist VBG cord-271526-14nfqusv 246 7 ciency ciency NN cord-271526-14nfqusv 246 8 of of IN cord-271526-14nfqusv 246 9 this this DT cord-271526-14nfqusv 246 10 interaction interaction NN cord-271526-14nfqusv 246 11 was be VBD cord-271526-14nfqusv 246 12 not not RB cord-271526-14nfqusv 246 13 determined determine VBN cord-271526-14nfqusv 246 14 . . . cord-271526-14nfqusv 247 1 A a DT cord-271526-14nfqusv 247 2 striking striking NN cord-271526-14nfqusv 247 3 of of IN cord-271526-14nfqusv 247 4 only only RB cord-271526-14nfqusv 247 5 the the DT cord-271526-14nfqusv 247 6 69-nt 69-nt CD cord-271526-14nfqusv 248 1 Ps Ps NNP cord-271526-14nfqusv 248 2 was be VBD cord-271526-14nfqusv 248 3 used use VBN cord-271526-14nfqusv 248 4 in in IN cord-271526-14nfqusv 248 5 our -PRON- PRP$ cord-271526-14nfqusv 248 6 studies study NNS cord-271526-14nfqusv 248 7 , , , cord-271526-14nfqusv 248 8 no no DT cord-271526-14nfqusv 248 9 gel gel NN cord-271526-14nfqusv 248 10 feature feature NN cord-271526-14nfqusv 248 11 of of IN cord-271526-14nfqusv 248 12 coronaviruses coronaviruse NNS cord-271526-14nfqusv 248 13 is be VBZ cord-271526-14nfqusv 248 14 that that IN cord-271526-14nfqusv 248 15 the the DT cord-271526-14nfqusv 248 16 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 248 17 has have VBZ cord-271526-14nfqusv 248 18 a a DT cord-271526-14nfqusv 248 19 retardation retardation NN cord-271526-14nfqusv 248 20 or or CC cord-271526-14nfqusv 248 21 UV uv NN cord-271526-14nfqusv 248 22 cross cross NN cord-271526-14nfqusv 248 23 - - NN cord-271526-14nfqusv 248 24 linking link VBG cord-271526-14nfqusv 248 25 to to IN cord-271526-14nfqusv 248 26 the the DT cord-271526-14nfqusv 248 27 N N NNP cord-271526-14nfqusv 248 28 protein protein NN cord-271526-14nfqusv 248 29 was be VBD cord-271526-14nfqusv 248 30 obhelical obhelical JJ cord-271526-14nfqusv 248 31 symmetry symmetry NN cord-271526-14nfqusv 249 1 ( ( -LRB- cord-271526-14nfqusv 249 2 MacNaughton MacNaughton NNP cord-271526-14nfqusv 249 3 et et FW cord-271526-14nfqusv 249 4 al al NNP cord-271526-14nfqusv 249 5 . . NNP cord-271526-14nfqusv 249 6 , , , cord-271526-14nfqusv 249 7 1978 1978 CD cord-271526-14nfqusv 249 8 ; ; : cord-271526-14nfqusv 249 9 _SP cord-271526-14nfqusv 249 10 Holmes Holmes NNP cord-271526-14nfqusv 249 11 and and CC cord-271526-14nfqusv 249 12 served serve VBD cord-271526-14nfqusv 249 13 ( ( -LRB- cord-271526-14nfqusv 249 14 unpublished unpublished JJ cord-271526-14nfqusv 249 15 observations observation NNS cord-271526-14nfqusv 249 16 ) ) -RRB- cord-271526-14nfqusv 249 17 . . . cord-271526-14nfqusv 250 1 Computer computer NN cord-271526-14nfqusv 250 2 prediction prediction NN cord-271526-14nfqusv 251 1 Behnke Behnke NNP cord-271526-14nfqusv 251 2 , , , cord-271526-14nfqusv 251 3 1981 1981 CD cord-271526-14nfqusv 251 4 ) ) -RRB- cord-271526-14nfqusv 251 5 , , , cord-271526-14nfqusv 251 6 in in IN cord-271526-14nfqusv 251 7 contrast contrast NN cord-271526-14nfqusv 251 8 to to IN cord-271526-14nfqusv 251 9 the the DT cord-271526-14nfqusv 251 10 nucleocapsids nucleocapsid NNS cord-271526-14nfqusv 251 11 of of IN cord-271526-14nfqusv 251 12 all all DT cord-271526-14nfqusv 251 13 of of IN cord-271526-14nfqusv 251 14 the the DT cord-271526-14nfqusv 251 15 secondary secondary JJ cord-271526-14nfqusv 251 16 structure structure NN cord-271526-14nfqusv 251 17 of of IN cord-271526-14nfqusv 251 18 this this DT cord-271526-14nfqusv 251 19 small small JJ cord-271526-14nfqusv 251 20 69-nt 69-nt CD cord-271526-14nfqusv 251 21 RNA RNA NNP cord-271526-14nfqusv 251 22 moleother moleother NN cord-271526-14nfqusv 251 23 positive positive JJ cord-271526-14nfqusv 251 24 stranded strand VBN cord-271526-14nfqusv 251 25 RNA RNA NNP cord-271526-14nfqusv 251 26 viruses virus NNS cord-271526-14nfqusv 251 27 , , , cord-271526-14nfqusv 251 28 which which WDT cord-271526-14nfqusv 251 29 are be VBP cord-271526-14nfqusv 251 30 icosaecule icosaecule NNP cord-271526-14nfqusv 251 31 showed show VBD cord-271526-14nfqusv 251 32 that that IN cord-271526-14nfqusv 251 33 the the DT cord-271526-14nfqusv 251 34 secondary secondary JJ cord-271526-14nfqusv 251 35 structure structure NN cord-271526-14nfqusv 251 36 was be VBD cord-271526-14nfqusv 251 37 entirely entirely RB cord-271526-14nfqusv 251 38 dral dral JJ cord-271526-14nfqusv 251 39 or or CC cord-271526-14nfqusv 251 40 spherical spherical JJ cord-271526-14nfqusv 252 1 ( ( -LRB- cord-271526-14nfqusv 252 2 Murphy Murphy NNP cord-271526-14nfqusv 252 3 et et NNP cord-271526-14nfqusv 252 4 al al NNP cord-271526-14nfqusv 252 5 . . NNP cord-271526-14nfqusv 252 6 , , , cord-271526-14nfqusv 252 7 1995 1995 CD cord-271526-14nfqusv 252 8 ) ) -RRB- cord-271526-14nfqusv 252 9 . . . cord-271526-14nfqusv 253 1 However however RB cord-271526-14nfqusv 253 2 , , , cord-271526-14nfqusv 253 3 electron electron NN cord-271526-14nfqusv 253 4 different different JJ cord-271526-14nfqusv 253 5 from from IN cord-271526-14nfqusv 253 6 that that DT cord-271526-14nfqusv 253 7 of of IN cord-271526-14nfqusv 253 8 the the DT cord-271526-14nfqusv 253 9 Ps Ps NNP cord-271526-14nfqusv 253 10 in in IN cord-271526-14nfqusv 253 11 the the DT cord-271526-14nfqusv 253 12 ORF1b ORF1b NNP cord-271526-14nfqusv 253 13 context context NN cord-271526-14nfqusv 253 14 . . . cord-271526-14nfqusv 254 1 This this DT cord-271526-14nfqusv 254 2 microscopy microscopy NN cord-271526-14nfqusv 254 3 studies study NNS cord-271526-14nfqusv 254 4 on on IN cord-271526-14nfqusv 254 5 the the DT cord-271526-14nfqusv 254 6 transmissible transmissible JJ cord-271526-14nfqusv 254 7 gastroenteritis gastroenteritis NN cord-271526-14nfqusv 254 8 suggests suggest VBZ cord-271526-14nfqusv 254 9 that that IN cord-271526-14nfqusv 254 10 the the DT cord-271526-14nfqusv 254 11 flanking flank VBG cord-271526-14nfqusv 254 12 ORF1b orf1b JJ cord-271526-14nfqusv 254 13 sequences sequence NNS cord-271526-14nfqusv 254 14 are be VBP cord-271526-14nfqusv 254 15 necescoronavirus necescoronavirus JJ cord-271526-14nfqusv 254 16 and and CC cord-271526-14nfqusv 254 17 MHV MHV NNP cord-271526-14nfqusv 254 18 ( ( -LRB- cord-271526-14nfqusv 254 19 Risco Risco NNP cord-271526-14nfqusv 254 20 et et NNP cord-271526-14nfqusv 254 21 al al NNP cord-271526-14nfqusv 254 22 . . NNP cord-271526-14nfqusv 254 23 , , , cord-271526-14nfqusv 254 24 1996 1996 CD cord-271526-14nfqusv 254 25 ) ) -RRB- cord-271526-14nfqusv 254 26 have have VBP cord-271526-14nfqusv 254 27 revealed reveal VBN cord-271526-14nfqusv 254 28 sary sary JJ cord-271526-14nfqusv 254 29 to to TO cord-271526-14nfqusv 254 30 force force VB cord-271526-14nfqusv 254 31 the the DT cord-271526-14nfqusv 254 32 Ps Ps NNP cord-271526-14nfqusv 254 33 in in IN cord-271526-14nfqusv 254 34 its -PRON- PRP$ cord-271526-14nfqusv 254 35 specific specific JJ cord-271526-14nfqusv 254 36 structure structure NN cord-271526-14nfqusv 254 37 or or CC cord-271526-14nfqusv 254 38 that that IN cord-271526-14nfqusv 254 39 the the DT cord-271526-14nfqusv 254 40 recently recently RB cord-271526-14nfqusv 254 41 a a DT cord-271526-14nfqusv 254 42 spherical spherical JJ cord-271526-14nfqusv 254 43 core core NN cord-271526-14nfqusv 254 44 structure structure NN cord-271526-14nfqusv 254 45 inside inside IN cord-271526-14nfqusv 254 46 the the DT cord-271526-14nfqusv 254 47 virion virion NN cord-271526-14nfqusv 254 48 ( ( -LRB- cord-271526-14nfqusv 254 49 intersmall intersmall NNP cord-271526-14nfqusv 254 50 RNA RNA NNP cord-271526-14nfqusv 254 51 probe probe NN cord-271526-14nfqusv 254 52 lacks lack VBZ cord-271526-14nfqusv 254 53 the the DT cord-271526-14nfqusv 254 54 flexibility flexibility NN cord-271526-14nfqusv 254 55 to to TO cord-271526-14nfqusv 254 56 form form VB cord-271526-14nfqusv 254 57 the the DT cord-271526-14nfqusv 254 58 specific specific JJ cord-271526-14nfqusv 254 59 nal nal FW cord-271526-14nfqusv 254 60 core core NN cord-271526-14nfqusv 254 61 ) ) -RRB- cord-271526-14nfqusv 254 62 and and CC cord-271526-14nfqusv 254 63 this this DT cord-271526-14nfqusv 254 64 structure structure NN cord-271526-14nfqusv 254 65 reacted react VBD cord-271526-14nfqusv 254 66 with with IN cord-271526-14nfqusv 254 67 M M NNP cord-271526-14nfqusv 254 68 - - HYPH cord-271526-14nfqusv 254 69 and and CC cord-271526-14nfqusv 254 70 N N NNP cord-271526-14nfqusv 254 71 - - HYPH cord-271526-14nfqusv 254 72 spestructure spestructure JJ cord-271526-14nfqusv 254 73 . . . cord-271526-14nfqusv 255 1 Recently recently RB cord-271526-14nfqusv 255 2 , , , cord-271526-14nfqusv 255 3 it -PRON- PRP cord-271526-14nfqusv 255 4 has have VBZ cord-271526-14nfqusv 255 5 been be VBN cord-271526-14nfqusv 255 6 shown show VBN cord-271526-14nfqusv 255 7 that that IN cord-271526-14nfqusv 255 8 the the DT cord-271526-14nfqusv 255 9 69-nt 69-nt CD cord-271526-14nfqusv 256 1 Ps ps UH cord-271526-14nfqusv 256 2 , , , cord-271526-14nfqusv 256 3 cific cific JJ cord-271526-14nfqusv 256 4 antibodies antibody NNS cord-271526-14nfqusv 256 5 . . . cord-271526-14nfqusv 257 1 A a DT cord-271526-14nfqusv 257 2 structural structural JJ cord-271526-14nfqusv 257 3 model model NN cord-271526-14nfqusv 257 4 for for IN cord-271526-14nfqusv 257 5 coronaviruses coronaviruse NNS cord-271526-14nfqusv 257 6 was be VBD cord-271526-14nfqusv 257 7 flanked flank VBN cord-271526-14nfqusv 257 8 by by IN cord-271526-14nfqusv 257 9 non non JJ cord-271526-14nfqusv 257 10 - - JJ cord-271526-14nfqusv 257 11 MHV mhv JJ cord-271526-14nfqusv 257 12 sequences sequence NNS cord-271526-14nfqusv 257 13 could could MD cord-271526-14nfqusv 257 14 confer confer VB cord-271526-14nfqusv 257 15 specific specific JJ cord-271526-14nfqusv 257 16 proposed propose VBN cord-271526-14nfqusv 257 17 , , , cord-271526-14nfqusv 257 18 in in IN cord-271526-14nfqusv 257 19 which which WDT cord-271526-14nfqusv 257 20 a a DT cord-271526-14nfqusv 257 21 spherical spherical JJ cord-271526-14nfqusv 257 22 core core NN cord-271526-14nfqusv 257 23 , , , cord-271526-14nfqusv 257 24 composed compose VBN cord-271526-14nfqusv 257 25 of of IN cord-271526-14nfqusv 257 26 a a DT cord-271526-14nfqusv 257 27 combination combination NN cord-271526-14nfqusv 257 28 of of IN cord-271526-14nfqusv 257 29 N N NNP cord-271526-14nfqusv 257 30 and and CC cord-271526-14nfqusv 257 31 M M NNP cord-271526-14nfqusv 257 32 proteins protein NNS cord-271526-14nfqusv 257 33 , , , cord-271526-14nfqusv 257 34 was be VBD cord-271526-14nfqusv 257 35 present present JJ cord-271526-14nfqusv 257 36 in in IN cord-271526-14nfqusv 257 37 addition addition NN cord-271526-14nfqusv 257 38 to to IN cord-271526-14nfqusv 257 39 encapsidation encapsidation NN cord-271526-14nfqusv 257 40 to to IN cord-271526-14nfqusv 257 41 a a DT cord-271526-14nfqusv 257 42 heterologous heterologous NNP cord-271526-14nfqusv 257 43 RNA RNA NNP cord-271526-14nfqusv 257 44 in in IN cord-271526-14nfqusv 257 45 MHV MHV NNP cord-271526-14nfqusv 258 1 infected infected JJ cord-271526-14nfqusv 258 2 INTERACTION interaction NN cord-271526-14nfqusv 258 3 BETWEEN between IN cord-271526-14nfqusv 258 4 NUCLEOCAPSID NUCLEOCAPSID NNP cord-271526-14nfqusv 258 5 PROTEIN PROTEIN NNP cord-271526-14nfqusv 258 6 AND and CC cord-271526-14nfqusv 258 7 PACKAGING packaging NN cord-271526-14nfqusv 258 8 SIGNAL signal NN cord-271526-14nfqusv 258 9 of of IN cord-271526-14nfqusv 258 10 a a DT cord-271526-14nfqusv 258 11 murine murine JJ cord-271526-14nfqusv 258 12 coronavirus coronavirus NN cord-271526-14nfqusv 258 13 in in IN cord-271526-14nfqusv 258 14 the the DT cord-271526-14nfqusv 258 15 absence absence NN cord-271526-14nfqusv 258 16 of of IN cord-271526-14nfqusv 258 17 helper helper NN cord-271526-14nfqusv 258 18 virus virus NN cord-271526-14nfqusv 258 19 . . . cord-271526-14nfqusv 259 1 Virology Virology NNP cord-271526-14nfqusv 259 2 218 218 CD cord-271526-14nfqusv 259 3 , , , cord-271526-14nfqusv 259 4 a a DT cord-271526-14nfqusv 259 5 helical helical JJ cord-271526-14nfqusv 259 6 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 259 7 . . . cord-271526-14nfqusv 260 1 It -PRON- PRP cord-271526-14nfqusv 260 2 will will MD cord-271526-14nfqusv 260 3 be be VB cord-271526-14nfqusv 260 4 of of IN cord-271526-14nfqusv 260 5 interest interest NN cord-271526-14nfqusv 260 6 to to TO cord-271526-14nfqusv 260 7 study study VB cord-271526-14nfqusv 260 8 the the DT cord-271526-14nfqusv 260 9 52 52 CD cord-271526-14nfqusv 260 10 - - SYM cord-271526-14nfqusv 260 11 60 60 CD cord-271526-14nfqusv 260 12 . . . cord-271526-14nfqusv 261 1 possible possible JJ cord-271526-14nfqusv 261 2 relationship relationship NN cord-271526-14nfqusv 261 3 between between IN cord-271526-14nfqusv 261 4 the the DT cord-271526-14nfqusv 261 5 morphology morphology NN cord-271526-14nfqusv 261 6 of of IN cord-271526-14nfqusv 261 7 the the DT cord-271526-14nfqusv 261 8 nu nu NNP cord-271526-14nfqusv 261 9 - - HYPH cord-271526-14nfqusv 261 10 Bos Bos NNP cord-271526-14nfqusv 261 11 , , , cord-271526-14nfqusv 261 12 E. E. NNP cord-271526-14nfqusv 261 13 C. C. NNP cord-271526-14nfqusv 261 14 W. W. NNP cord-271526-14nfqusv 261 15 , , , cord-271526-14nfqusv 261 16 Dobbe Dobbe NNP cord-271526-14nfqusv 261 17 , , , cord-271526-14nfqusv 261 18 J. J. NNP cord-271526-14nfqusv 261 19 , , , cord-271526-14nfqusv 261 20 Luytjes Luytjes NNP cord-271526-14nfqusv 261 21 , , , cord-271526-14nfqusv 261 22 W. W. NNP cord-271526-14nfqusv 261 23 , , , cord-271526-14nfqusv 261 24 and and CC cord-271526-14nfqusv 261 25 Spaan Spaan NNP cord-271526-14nfqusv 261 26 , , , cord-271526-14nfqusv 261 27 W. W. NNP cord-271526-14nfqusv 261 28 J. J. NNP cord-271526-14nfqusv 261 29 M. M. NNP cord-271526-14nfqusv 261 30 ( ( -LRB- cord-271526-14nfqusv 261 31 1997 1997 CD cord-271526-14nfqusv 261 32 ) ) -RRB- cord-271526-14nfqusv 261 33 . . . cord-271526-14nfqusv 262 1 A a DT cord-271526-14nfqusv 262 2 subcleocapsid subcleocapsid JJ cord-271526-14nfqusv 262 3 or or CC cord-271526-14nfqusv 262 4 internal internal JJ cord-271526-14nfqusv 262 5 core core NN cord-271526-14nfqusv 262 6 and and CC cord-271526-14nfqusv 262 7 the the DT cord-271526-14nfqusv 262 8 mechanism mechanism NN cord-271526-14nfqusv 262 9 of of IN cord-271526-14nfqusv 262 10 encapgenomic encapgenomic NNP cord-271526-14nfqusv 262 11 mRNA mRNA NNP cord-271526-14nfqusv 262 12 transcript transcript NN cord-271526-14nfqusv 262 13 of of IN cord-271526-14nfqusv 262 14 the the DT cord-271526-14nfqusv 262 15 coronavirus coronavirus NN cord-271526-14nfqusv 262 16 mouse mouse NN cord-271526-14nfqusv 262 17 hepatitis hepatitis NN cord-271526-14nfqusv 262 18 virus virus NN cord-271526-14nfqusv 262 19 sidation sidation NN cord-271526-14nfqusv 262 20 initiation initiation NN cord-271526-14nfqusv 262 21 . . . cord-271526-14nfqusv 263 1 strain strain VB cord-271526-14nfqusv 263 2 A59 A59 NNP cord-271526-14nfqusv 263 3 defective defective JJ cord-271526-14nfqusv 263 4 interfering interfere VBG cord-271526-14nfqusv 264 1 ( ( -LRB- cord-271526-14nfqusv 264 2 DI DI NNP cord-271526-14nfqusv 264 3 ) ) -RRB- cord-271526-14nfqusv 264 4 RNA RNA NNP cord-271526-14nfqusv 264 5 is be VBZ cord-271526-14nfqusv 264 6 packaged package VBN cord-271526-14nfqusv 264 7 when when WRB cord-271526-14nfqusv 264 8 it -PRON- PRP cord-271526-14nfqusv 264 9 contains contain VBZ cord-271526-14nfqusv 264 10 It -PRON- PRP cord-271526-14nfqusv 264 11 has have VBZ cord-271526-14nfqusv 264 12 been be VBN cord-271526-14nfqusv 264 13 shown show VBN cord-271526-14nfqusv 264 14 that that IN cord-271526-14nfqusv 264 15 , , , cord-271526-14nfqusv 264 16 as as IN cord-271526-14nfqusv 264 17 opposed oppose VBN cord-271526-14nfqusv 264 18 to to IN cord-271526-14nfqusv 264 19 alphavirus alphavirus NNP cord-271526-14nfqusv 264 20 asthe asthe JJ cord-271526-14nfqusv 264 21 DI DI NNP cord-271526-14nfqusv 264 22 packaging packaging NN cord-271526-14nfqusv 264 23 signal signal NN cord-271526-14nfqusv 264 24 . . . cord-271526-14nfqusv 265 1 J. J. NNP cord-271526-14nfqusv 265 2 Virol Virol NNP cord-271526-14nfqusv 265 3 . . . cord-271526-14nfqusv 266 1 71 71 CD cord-271526-14nfqusv 266 2 , , , cord-271526-14nfqusv 266 3 5684 5684 CD cord-271526-14nfqusv 266 4 - - SYM cord-271526-14nfqusv 266 5 5687 5687 CD cord-271526-14nfqusv 266 6 . . . cord-271526-14nfqusv 267 1 Bredenbeek Bredenbeek NNP cord-271526-14nfqusv 267 2 , , , cord-271526-14nfqusv 267 3 P. P. NNP cord-271526-14nfqusv 267 4 J. J. NNP cord-271526-14nfqusv 267 5 ( ( -LRB- cord-271526-14nfqusv 267 6 1990 1990 CD cord-271526-14nfqusv 267 7 ) ) -RRB- cord-271526-14nfqusv 267 8 . . . cord-271526-14nfqusv 267 9 '' '' '' cord-271526-14nfqusv 268 1 Nucleic nucleic JJ cord-271526-14nfqusv 268 2 Acid acid NN cord-271526-14nfqusv 268 3 Domains domain NNS cord-271526-14nfqusv 268 4 and and CC cord-271526-14nfqusv 269 1 Proteins protein NNS cord-271526-14nfqusv 269 2 Involved involve VBN cord-271526-14nfqusv 269 3 sembly sembly RB cord-271526-14nfqusv 269 4 , , , cord-271526-14nfqusv 269 5 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 269 6 formation formation NN cord-271526-14nfqusv 269 7 and and CC cord-271526-14nfqusv 269 8 RNA RNA NNP cord-271526-14nfqusv 269 9 encapsidation encapsidation NN cord-271526-14nfqusv 269 10 in in IN cord-271526-14nfqusv 269 11 the the DT cord-271526-14nfqusv 269 12 Replication Replication NNP cord-271526-14nfqusv 269 13 of of IN cord-271526-14nfqusv 269 14 Coronaviruses Coronaviruses NNPS cord-271526-14nfqusv 269 15 . . . cord-271526-14nfqusv 269 16 ' ' '' cord-271526-14nfqusv 269 17 ' ' '' cord-271526-14nfqusv 270 1 Ph.D. Ph.D. NNP cord-271526-14nfqusv 270 2 Thesis Thesis NNP cord-271526-14nfqusv 270 3 , , , cord-271526-14nfqusv 270 4 University University NNP cord-271526-14nfqusv 270 5 of of IN cord-271526-14nfqusv 270 6 are be VBP cord-271526-14nfqusv 270 7 not not RB cord-271526-14nfqusv 270 8 strictly strictly RB cord-271526-14nfqusv 270 9 required require VBN cord-271526-14nfqusv 270 10 for for IN cord-271526-14nfqusv 270 11 virion virion NN cord-271526-14nfqusv 270 12 formation formation NN cord-271526-14nfqusv 270 13 ( ( -LRB- cord-271526-14nfqusv 270 14 Vennema Vennema NNP cord-271526-14nfqusv 270 15 et et FW cord-271526-14nfqusv 270 16 Utrecht Utrecht NNP cord-271526-14nfqusv 270 17 , , , cord-271526-14nfqusv 270 18 Utrecht Utrecht NNP cord-271526-14nfqusv 270 19 , , , cord-271526-14nfqusv 270 20 The the DT cord-271526-14nfqusv 270 21 Netherlands Netherlands NNP cord-271526-14nfqusv 270 22 . . . cord-271526-14nfqusv 271 1 al al NNP cord-271526-14nfqusv 271 2 . . NNP cord-271526-14nfqusv 271 3 , , , cord-271526-14nfqusv 271 4 1996 1996 CD cord-271526-14nfqusv 271 5 ; ; : cord-271526-14nfqusv 271 6 Strauss Strauss NNP cord-271526-14nfqusv 271 7 and and CC cord-271526-14nfqusv 271 8 Strauss Strauss NNP cord-271526-14nfqusv 271 9 , , , cord-271526-14nfqusv 271 10 1994 1994 CD cord-271526-14nfqusv 271 11 ) ) -RRB- cord-271526-14nfqusv 271 12 . . . cord-271526-14nfqusv 272 1 Burd Burd NNP cord-271526-14nfqusv 272 2 , , , cord-271526-14nfqusv 272 3 C. C. NNP cord-271526-14nfqusv 272 4 G. G. NNP cord-271526-14nfqusv 272 5 , , , cord-271526-14nfqusv 272 6 and and CC cord-271526-14nfqusv 272 7 Dreyfuss Dreyfuss NNP cord-271526-14nfqusv 272 8 , , , cord-271526-14nfqusv 272 9 G. G. NNP cord-271526-14nfqusv 272 10 ( ( -LRB- cord-271526-14nfqusv 272 11 1994 1994 CD cord-271526-14nfqusv 272 12 ) ) -RRB- cord-271526-14nfqusv 272 13 . . . cord-271526-14nfqusv 273 1 Conserved conserved JJ cord-271526-14nfqusv 273 2 structures structure NNS cord-271526-14nfqusv 273 3 and and CC cord-271526-14nfqusv 273 4 diversity diversity NN cord-271526-14nfqusv 273 5 Coexpression Coexpression NNP cord-271526-14nfqusv 273 6 of of IN cord-271526-14nfqusv 273 7 M M NNP cord-271526-14nfqusv 273 8 and and CC cord-271526-14nfqusv 273 9 E E NNP cord-271526-14nfqusv 273 10 protein protein NN cord-271526-14nfqusv 273 11 was be VBD cord-271526-14nfqusv 273 12 sufficient sufficient JJ cord-271526-14nfqusv 273 13 for for IN cord-271526-14nfqusv 273 14 partiof partiof NN cord-271526-14nfqusv 273 15 functions function NNS cord-271526-14nfqusv 273 16 of of IN cord-271526-14nfqusv 273 17 RNA RNA NNP cord-271526-14nfqusv 273 18 - - HYPH cord-271526-14nfqusv 273 19 binding bind VBG cord-271526-14nfqusv 273 20 proteins protein NNS cord-271526-14nfqusv 273 21 . . . cord-271526-14nfqusv 274 1 Science Science NNP cord-271526-14nfqusv 274 2 265 265 CD cord-271526-14nfqusv 274 3 , , , cord-271526-14nfqusv 274 4 615 615 CD cord-271526-14nfqusv 274 5 - - SYM cord-271526-14nfqusv 274 6 621 621 CD cord-271526-14nfqusv 274 7 . . . cord-271526-14nfqusv 275 1 cle cle NNP cord-271526-14nfqusv 275 2 formation formation NN cord-271526-14nfqusv 275 3 . . . cord-271526-14nfqusv 276 1 However however RB cord-271526-14nfqusv 276 2 , , , cord-271526-14nfqusv 276 3 incorporation incorporation NN cord-271526-14nfqusv 276 4 of of IN cord-271526-14nfqusv 276 5 nucleocapsids nucleocapsids NNP cord-271526-14nfqusv 276 6 Dignam Dignam NNP cord-271526-14nfqusv 276 7 , , , cord-271526-14nfqusv 276 8 J. J. NNP cord-271526-14nfqusv 276 9 D. D. NNP cord-271526-14nfqusv 276 10 , , , cord-271526-14nfqusv 276 11 Lebowitz Lebowitz NNP cord-271526-14nfqusv 276 12 , , , cord-271526-14nfqusv 276 13 R. R. NNP cord-271526-14nfqusv 276 14 M. M. NNP cord-271526-14nfqusv 276 15 , , , cord-271526-14nfqusv 276 16 and and CC cord-271526-14nfqusv 276 17 Roeder Roeder NNP cord-271526-14nfqusv 276 18 , , , cord-271526-14nfqusv 276 19 R. R. NNP cord-271526-14nfqusv 276 20 G. G. NNP cord-271526-14nfqusv 276 21 ( ( -LRB- cord-271526-14nfqusv 276 22 1983 1983 CD cord-271526-14nfqusv 276 23 ) ) -RRB- cord-271526-14nfqusv 276 24 . . . cord-271526-14nfqusv 277 1 Acurate acurate NN cord-271526-14nfqusv 277 2 transcription transcription NN cord-271526-14nfqusv 277 3 initiation initiation NN cord-271526-14nfqusv 277 4 by by IN cord-271526-14nfqusv 277 5 RNA RNA NNP cord-271526-14nfqusv 277 6 polymerase polymerase NN cord-271526-14nfqusv 277 7 II II NNP cord-271526-14nfqusv 277 8 in in IN cord-271526-14nfqusv 277 9 a a DT cord-271526-14nfqusv 277 10 soluble soluble JJ cord-271526-14nfqusv 277 11 extract extract NN cord-271526-14nfqusv 277 12 from from IN cord-271526-14nfqusv 277 13 during during IN cord-271526-14nfqusv 277 14 the the DT cord-271526-14nfqusv 277 15 budding budding JJ cord-271526-14nfqusv 277 16 process process NN cord-271526-14nfqusv 277 17 could could MD cord-271526-14nfqusv 277 18 greatly greatly RB cord-271526-14nfqusv 277 19 increase increase VB cord-271526-14nfqusv 277 20 the the DT cord-271526-14nfqusv 277 21 isolated isolated JJ cord-271526-14nfqusv 277 22 mammalian mammalian JJ cord-271526-14nfqusv 277 23 nuclei nucleus NNS cord-271526-14nfqusv 277 24 . . . cord-271526-14nfqusv 278 1 Nucleic nucleic JJ cord-271526-14nfqusv 278 2 Acids acid NNS cord-271526-14nfqusv 278 3 Res Res NNP cord-271526-14nfqusv 278 4 . . . cord-271526-14nfqusv 279 1 11 11 CD cord-271526-14nfqusv 279 2 , , , cord-271526-14nfqusv 279 3 1475 1475 CD cord-271526-14nfqusv 279 4 Res res NN cord-271526-14nfqusv 279 5 . . NNP cord-271526-14nfqusv 279 6 11 11 CD cord-271526-14nfqusv 279 7 , , , cord-271526-14nfqusv 279 8 -1489 -1489 JJ cord-271526-14nfqusv 279 9 efficiency efficiency NN cord-271526-14nfqusv 279 10 of of IN cord-271526-14nfqusv 279 11 virion virion NN cord-271526-14nfqusv 279 12 formation formation NN cord-271526-14nfqusv 279 13 . . . cord-271526-14nfqusv 280 1 Draper Draper NNP cord-271526-14nfqusv 280 2 , , , cord-271526-14nfqusv 280 3 D. D. NNP cord-271526-14nfqusv 280 4 E. E. NNP cord-271526-14nfqusv 280 5 ( ( -LRB- cord-271526-14nfqusv 280 6 1995 1995 CD cord-271526-14nfqusv 280 7 ) ) -RRB- cord-271526-14nfqusv 280 8 . . . cord-271526-14nfqusv 281 1 Protein Protein NNP cord-271526-14nfqusv 281 2 - - HYPH cord-271526-14nfqusv 281 3 RNA RNA NNP cord-271526-14nfqusv 281 4 recognition recognition NN cord-271526-14nfqusv 281 5 . . . cord-271526-14nfqusv 282 1 Annu Annu NNP cord-271526-14nfqusv 282 2 . . . cord-271526-14nfqusv 283 1 Rev. Rev. NNP cord-271526-14nfqusv 283 2 Biochem Biochem NNP cord-271526-14nfqusv 283 3 . . . cord-271526-14nfqusv 284 1 64 64 CD cord-271526-14nfqusv 284 2 , , , cord-271526-14nfqusv 284 3 The the DT cord-271526-14nfqusv 284 4 study study NN cord-271526-14nfqusv 284 5 of of IN cord-271526-14nfqusv 284 6 the the DT cord-271526-14nfqusv 284 7 encapsidation encapsidation NN cord-271526-14nfqusv 284 8 of of IN cord-271526-14nfqusv 284 9 coronaviruses coronaviruse NNS cord-271526-14nfqusv 284 10 is be VBZ cord-271526-14nfqusv 284 11 593 593 CD cord-271526-14nfqusv 284 12 - - SYM cord-271526-14nfqusv 284 13 620 620 CD cord-271526-14nfqusv 284 14 . . . cord-271526-14nfqusv 285 1 greatly greatly RB cord-271526-14nfqusv 285 2 hampered hamper VBN cord-271526-14nfqusv 285 3 by by IN cord-271526-14nfqusv 285 4 the the DT cord-271526-14nfqusv 285 5 absence absence NN cord-271526-14nfqusv 285 6 of of IN cord-271526-14nfqusv 285 7 an an DT cord-271526-14nfqusv 285 8 infectious infectious JJ cord-271526-14nfqusv 285 9 clone clone NN cord-271526-14nfqusv 285 10 . . . cord-271526-14nfqusv 286 1 Dubois Dubois NNP cord-271526-14nfqusv 286 2 - - HYPH cord-271526-14nfqusv 286 3 Dalcq Dalcq NNP cord-271526-14nfqusv 286 4 , , , cord-271526-14nfqusv 286 5 M. M. NNP cord-271526-14nfqusv 286 6 E. E. NNP cord-271526-14nfqusv 286 7 , , , cord-271526-14nfqusv 286 8 Doller Doller NNP cord-271526-14nfqusv 286 9 , , , cord-271526-14nfqusv 286 10 E. E. NNP cord-271526-14nfqusv 286 11 W. W. NNP cord-271526-14nfqusv 286 12 , , , cord-271526-14nfqusv 286 13 Haspel Haspel NNP cord-271526-14nfqusv 286 14 , , , cord-271526-14nfqusv 286 15 M. M. NNP cord-271526-14nfqusv 286 16 V. V. NNP cord-271526-14nfqusv 286 17 , , , cord-271526-14nfqusv 286 18 and and CC cord-271526-14nfqusv 286 19 Holmes Holmes NNP cord-271526-14nfqusv 286 20 , , , cord-271526-14nfqusv 286 21 K. K. NNP cord-271526-14nfqusv 286 22 V. V. NNP cord-271526-14nfqusv 287 1 The the DT cord-271526-14nfqusv 287 2 in in IN cord-271526-14nfqusv 287 3 vitro vitro FW cord-271526-14nfqusv 287 4 binding bind VBG cord-271526-14nfqusv 287 5 assay assay NN cord-271526-14nfqusv 287 6 , , , cord-271526-14nfqusv 287 7 described describe VBN cord-271526-14nfqusv 287 8 in in IN cord-271526-14nfqusv 287 9 this this DT cord-271526-14nfqusv 287 10 report report NN cord-271526-14nfqusv 287 11 , , , cord-271526-14nfqusv 287 12 can can MD cord-271526-14nfqusv 287 13 ( ( -LRB- cord-271526-14nfqusv 287 14 1982 1982 CD cord-271526-14nfqusv 287 15 ) ) -RRB- cord-271526-14nfqusv 287 16 . . . cord-271526-14nfqusv 288 1 Cell cell NN cord-271526-14nfqusv 288 2 tropism tropism NN cord-271526-14nfqusv 288 3 and and CC cord-271526-14nfqusv 288 4 expression expression NN cord-271526-14nfqusv 288 5 of of IN cord-271526-14nfqusv 288 6 mouse mouse NN cord-271526-14nfqusv 288 7 hepatitis hepatitis NN cord-271526-14nfqusv 288 8 viruses virus NNS cord-271526-14nfqusv 288 9 ( ( -LRB- cord-271526-14nfqusv 288 10 MHV MHV NNP cord-271526-14nfqusv 288 11 ) ) -RRB- cord-271526-14nfqusv 288 12 greatly greatly RB cord-271526-14nfqusv 288 13 enhance enhance VB cord-271526-14nfqusv 288 14 our -PRON- PRP$ cord-271526-14nfqusv 288 15 understanding understanding NN cord-271526-14nfqusv 288 16 of of IN cord-271526-14nfqusv 288 17 the the DT cord-271526-14nfqusv 288 18 encapsidation encapsidation NN cord-271526-14nfqusv 288 19 in in IN cord-271526-14nfqusv 288 20 mouse mouse NN cord-271526-14nfqusv 288 21 spinal spinal JJ cord-271526-14nfqusv 288 22 cord cord NN cord-271526-14nfqusv 288 23 cultures culture NNS cord-271526-14nfqusv 288 24 . . . cord-271526-14nfqusv 289 1 Virology Virology NNP cord-271526-14nfqusv 289 2 119 119 CD cord-271526-14nfqusv 289 3 , , , cord-271526-14nfqusv 289 4 317 317 CD cord-271526-14nfqusv 289 5 - - SYM cord-271526-14nfqusv 289 6 331 331 CD cord-271526-14nfqusv 289 7 . . . cord-271526-14nfqusv 290 1 Dupraz Dupraz NNP cord-271526-14nfqusv 290 2 , , , cord-271526-14nfqusv 290 3 P. P. NNP cord-271526-14nfqusv 290 4 , , , cord-271526-14nfqusv 290 5 and and CC cord-271526-14nfqusv 290 6 Spahr Spahr NNP cord-271526-14nfqusv 290 7 , , , cord-271526-14nfqusv 290 8 P. P. NNP cord-271526-14nfqusv 290 9 F. F. NNP cord-271526-14nfqusv 290 10 ( ( -LRB- cord-271526-14nfqusv 290 11 1992 1992 CD cord-271526-14nfqusv 290 12 ) ) -RRB- cord-271526-14nfqusv 290 13 . . . cord-271526-14nfqusv 291 1 Specificity specificity NN cord-271526-14nfqusv 291 2 of of IN cord-271526-14nfqusv 291 3 Rous rous JJ cord-271526-14nfqusv 291 4 sarcoma sarcoma NN cord-271526-14nfqusv 291 5 virus virus NN cord-271526-14nfqusv 291 6 mechanism mechanism NN cord-271526-14nfqusv 291 7 . . . cord-271526-14nfqusv 292 1 We -PRON- PRP cord-271526-14nfqusv 292 2 have have VBP cord-271526-14nfqusv 292 3 shown show VBN cord-271526-14nfqusv 292 4 that that IN cord-271526-14nfqusv 292 5 recombinant recombinant JJ cord-271526-14nfqusv 292 6 nucleonucleocapsid nucleonucleocapsid NNP cord-271526-14nfqusv 292 7 protein protein NN cord-271526-14nfqusv 292 8 in in IN cord-271526-14nfqusv 292 9 genomic genomic JJ cord-271526-14nfqusv 292 10 RNA RNA NNP cord-271526-14nfqusv 292 11 packaging packaging NN cord-271526-14nfqusv 292 12 . . . cord-271526-14nfqusv 293 1 J. J. NNP cord-271526-14nfqusv 293 2 Virol Virol NNP cord-271526-14nfqusv 293 3 . . . cord-271526-14nfqusv 294 1 66 66 CD cord-271526-14nfqusv 294 2 , , , cord-271526-14nfqusv 294 3 capsid capsid NN cord-271526-14nfqusv 294 4 protein protein NN cord-271526-14nfqusv 294 5 expressed express VBN cord-271526-14nfqusv 294 6 in in IN cord-271526-14nfqusv 294 7 the the DT cord-271526-14nfqusv 294 8 vTF7 vTF7 NNP cord-271526-14nfqusv 294 9 expression expression NN cord-271526-14nfqusv 294 10 system system NN cord-271526-14nfqusv 294 11 4670 4670 CD cord-271526-14nfqusv 294 12 . . . cord-271526-14nfqusv 295 1 is be VBZ cord-271526-14nfqusv 295 2 able able JJ cord-271526-14nfqusv 295 3 to to TO cord-271526-14nfqusv 295 4 interact interact VB cord-271526-14nfqusv 295 5 with with IN cord-271526-14nfqusv 295 6 the the DT cord-271526-14nfqusv 295 7 Ps Ps NNP cord-271526-14nfqusv 295 8 in in IN cord-271526-14nfqusv 295 9 a a DT cord-271526-14nfqusv 295 10 similar similar JJ cord-271526-14nfqusv 295 11 fashion fashion NN cord-271526-14nfqusv 295 12 as as IN cord-271526-14nfqusv 295 13 the the DT cord-271526-14nfqusv 295 14 Fischer Fischer NNP cord-271526-14nfqusv 295 15 , , , cord-271526-14nfqusv 295 16 F. F. NNP cord-271526-14nfqusv 295 17 , , , cord-271526-14nfqusv 295 18 Peng Peng NNP cord-271526-14nfqusv 295 19 , , , cord-271526-14nfqusv 295 20 D. D. NNP cord-271526-14nfqusv 295 21 , , , cord-271526-14nfqusv 295 22 Hingley Hingley NNP cord-271526-14nfqusv 295 23 , , , cord-271526-14nfqusv 295 24 S. S. NNP cord-271526-14nfqusv 295 25 T. T. NNP cord-271526-14nfqusv 295 26 , , , cord-271526-14nfqusv 295 27 Weiss Weiss NNP cord-271526-14nfqusv 295 28 , , , cord-271526-14nfqusv 295 29 S. S. NNP cord-271526-14nfqusv 295 30 R. R. NNP cord-271526-14nfqusv 295 31 , , , cord-271526-14nfqusv 295 32 and and CC cord-271526-14nfqusv 295 33 Masters Masters NNPS cord-271526-14nfqusv 295 34 , , , cord-271526-14nfqusv 295 35 P. P. NNP cord-271526-14nfqusv 295 36 S. S. NNP cord-271526-14nfqusv 295 37 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 295 38 protein protein NN cord-271526-14nfqusv 295 39 produced produce VBN cord-271526-14nfqusv 295 40 in in IN cord-271526-14nfqusv 295 41 infected infected JJ cord-271526-14nfqusv 295 42 cells cell NNS cord-271526-14nfqusv 295 43 . . . cord-271526-14nfqusv 296 1 Muta- Muta- NNPS cord-271526-14nfqusv 296 2 ( ( -LRB- cord-271526-14nfqusv 296 3 1997 1997 CD cord-271526-14nfqusv 296 4 ) ) -RRB- cord-271526-14nfqusv 296 5 . . . cord-271526-14nfqusv 297 1 The the DT cord-271526-14nfqusv 297 2 internal internal JJ cord-271526-14nfqusv 297 3 open open JJ cord-271526-14nfqusv 297 4 reading reading NN cord-271526-14nfqusv 297 5 frame frame NN cord-271526-14nfqusv 297 6 within within IN cord-271526-14nfqusv 297 7 the the DT cord-271526-14nfqusv 297 8 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 297 9 gene gene NNP cord-271526-14nfqusv 297 10 tional tional JJ cord-271526-14nfqusv 297 11 analysis analysis NN cord-271526-14nfqusv 297 12 of of IN cord-271526-14nfqusv 297 13 both both CC cord-271526-14nfqusv 297 14 the the DT cord-271526-14nfqusv 297 15 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 297 16 protein protein NN cord-271526-14nfqusv 297 17 and and CC cord-271526-14nfqusv 297 18 the the DT cord-271526-14nfqusv 297 19 of of IN cord-271526-14nfqusv 297 20 mouse mouse NNP cord-271526-14nfqusv 297 21 hepatitis hepatitis NNP cord-271526-14nfqusv 297 22 virus virus NN cord-271526-14nfqusv 297 23 encodes encode VBZ cord-271526-14nfqusv 297 24 a a DT cord-271526-14nfqusv 297 25 structural structural JJ cord-271526-14nfqusv 297 26 protein protein NN cord-271526-14nfqusv 297 27 that that WDT cord-271526-14nfqusv 297 28 is be VBZ cord-271526-14nfqusv 297 29 not not RB cord-271526-14nfqusv 297 30 essential essential JJ cord-271526-14nfqusv 297 31 for for IN cord-271526-14nfqusv 297 32 viral viral JJ cord-271526-14nfqusv 297 33 replication replication NN cord-271526-14nfqusv 297 34 . . . cord-271526-14nfqusv 298 1 J. J. NNP cord-271526-14nfqusv 298 2 Virol Virol NNP cord-271526-14nfqusv 298 3 . . . cord-271526-14nfqusv 299 1 71 71 CD cord-271526-14nfqusv 299 2 , , , cord-271526-14nfqusv 299 3 996 996 CD cord-271526-14nfqusv 299 4 - - SYM cord-271526-14nfqusv 299 5 1003 1003 CD cord-271526-14nfqusv 299 6 . . . cord-271526-14nfqusv 300 1 Ps Ps NNP cord-271526-14nfqusv 300 2 should should MD cord-271526-14nfqusv 300 3 provide provide VB cord-271526-14nfqusv 300 4 us -PRON- PRP cord-271526-14nfqusv 300 5 with with IN cord-271526-14nfqusv 300 6 information information NN cord-271526-14nfqusv 300 7 that that WDT cord-271526-14nfqusv 300 8 allows allow VBZ cord-271526-14nfqusv 300 9 us -PRON- PRP cord-271526-14nfqusv 300 10 to to IN cord-271526-14nfqusv 300 11 Fosmire Fosmire NNP cord-271526-14nfqusv 300 12 , , , cord-271526-14nfqusv 300 13 J. J. NNP cord-271526-14nfqusv 300 14 A. A. NNP cord-271526-14nfqusv 300 15 , , , cord-271526-14nfqusv 300 16 Hwang Hwang NNP cord-271526-14nfqusv 300 17 , , , cord-271526-14nfqusv 300 18 K. K. NNP cord-271526-14nfqusv 300 19 , , , cord-271526-14nfqusv 300 20 and and CC cord-271526-14nfqusv 300 21 Makino Makino NNP cord-271526-14nfqusv 300 22 , , , cord-271526-14nfqusv 300 23 S. S. NNP cord-271526-14nfqusv 300 24 ( ( -LRB- cord-271526-14nfqusv 300 25 1992 1992 CD cord-271526-14nfqusv 300 26 ) ) -RRB- cord-271526-14nfqusv 300 27 . . . cord-271526-14nfqusv 301 1 Identification identification NN cord-271526-14nfqusv 301 2 and and CC cord-271526-14nfqusv 301 3 understand understand VB cord-271526-14nfqusv 301 4 the the DT cord-271526-14nfqusv 301 5 encapsidation encapsidation NN cord-271526-14nfqusv 301 6 mechanism mechanism NN cord-271526-14nfqusv 301 7 in in IN cord-271526-14nfqusv 301 8 more more JJR cord-271526-14nfqusv 301 9 detail detail NN cord-271526-14nfqusv 301 10 . . . cord-271526-14nfqusv 302 1 characterization characterization NN cord-271526-14nfqusv 302 2 of of IN cord-271526-14nfqusv 302 3 a a DT cord-271526-14nfqusv 302 4 coronavirus coronavirus NN cord-271526-14nfqusv 302 5 packaging packaging NN cord-271526-14nfqusv 302 6 signal signal NN cord-271526-14nfqusv 302 7 . . . cord-271526-14nfqusv 303 1 J. J. NNP cord-271526-14nfqusv 303 2 Virol Virol NNP cord-271526-14nfqusv 303 3 . . . cord-271526-14nfqusv 304 1 66 66 CD cord-271526-14nfqusv 304 2 , , , cord-271526-14nfqusv 304 3 3522 3522 CD cord-271526-14nfqusv 304 4 - - HYPH cord-271526-14nfqusv 304 5 3530 3530 CD cord-271526-14nfqusv 304 6 . . . cord-271526-14nfqusv 305 1 Holmes Holmes NNP cord-271526-14nfqusv 305 2 , , , cord-271526-14nfqusv 305 3 K. K. NNP cord-271526-14nfqusv 305 4 V. V. NNP cord-271526-14nfqusv 305 5 ( ( -LRB- cord-271526-14nfqusv 305 6 1991 1991 CD cord-271526-14nfqusv 305 7 ) ) -RRB- cord-271526-14nfqusv 305 8 . . . cord-271526-14nfqusv 306 1 In in IN cord-271526-14nfqusv 306 2 ' ' `` cord-271526-14nfqusv 306 3 ' ' `` cord-271526-14nfqusv 306 4 Fundamental Fundamental NNP cord-271526-14nfqusv 306 5 Virology Virology NNP cord-271526-14nfqusv 306 6 ' ' '' cord-271526-14nfqusv 306 7 ' ' '' cord-271526-14nfqusv 306 8 ( ( -LRB- cord-271526-14nfqusv 306 9 B. B. NNP cord-271526-14nfqusv 306 10 N. N. NNP cord-271526-14nfqusv 306 11 Fields Fields NNP cord-271526-14nfqusv 306 12 and and CC cord-271526-14nfqusv 306 13 D. D. NNP cord-271526-14nfqusv 306 14 M. M. NNP cord-271526-14nfqusv 306 15 Sequence Sequence NNP cord-271526-14nfqusv 306 16 specific specific JJ cord-271526-14nfqusv 306 17 sequences sequence NNS cord-271526-14nfqusv 306 18 involved involve VBN cord-271526-14nfqusv 306 19 in in IN cord-271526-14nfqusv 306 20 human human JJ cord-271526-14nfqusv 306 21 immunodeficiency immunodeficiency NN cord-271526-14nfqusv 306 22 virus virus NN cord-271526-14nfqusv 306 23 type type NN cord-271526-14nfqusv 306 24 1 1 CD cord-271526-14nfqusv 306 25 packagrecognition packagrecognition NN cord-271526-14nfqusv 306 26 of of IN cord-271526-14nfqusv 306 27 RNA RNA NNP cord-271526-14nfqusv 306 28 hairpins hairpin NNS cord-271526-14nfqusv 306 29 by by IN cord-271526-14nfqusv 306 30 bacteriophage bacteriophage NN cord-271526-14nfqusv 306 31 antiterminators antiterminator NNS cord-271526-14nfqusv 306 32 reing ree VBG cord-271526-14nfqusv 306 33 result result NN cord-271526-14nfqusv 306 34 in in IN cord-271526-14nfqusv 306 35 production production NN cord-271526-14nfqusv 306 36 of of IN cord-271526-14nfqusv 306 37 noninfectious noninfectious JJ cord-271526-14nfqusv 306 38 virus virus NN cord-271526-14nfqusv 306 39 646-Characterisation 646-characterisation CD cord-271526-14nfqusv 306 40 of of IN cord-271526-14nfqusv 306 41 two two CD cord-271526-14nfqusv 306 42 temperature temperature NN cord-271526-14nfqusv 306 43 - - HYPH cord-271526-14nfqusv 306 44 sensitive sensitive JJ cord-271526-14nfqusv 306 45 mutants mutant NNS cord-271526-14nfqusv 306 46 of of IN cord-271526-14nfqusv 306 47 coronavi-650 coronavi-650 NNP cord-271526-14nfqusv 306 48 Ribo-232 ribo-232 DT cord-271526-14nfqusv 306 49 . . . cord-271526-14nfqusv 306 50 nucleoprotein nucleoprotein JJ cord-271526-14nfqusv 306 51 - - HYPH cord-271526-14nfqusv 306 52 like like JJ cord-271526-14nfqusv 306 53 structures structure NNS cord-271526-14nfqusv 306 54 from from IN cord-271526-14nfqusv 306 55 coronavirus coronavirus NN cord-271526-14nfqusv 306 56 particles particle NNS cord-271526-14nfqusv 306 57 Sequence sequence NN cord-271526-14nfqusv 306 58 of of IN cord-271526-14nfqusv 306 59 39 39 CD cord-271526-14nfqusv 306 60 Endosomal Endosomal NNP cord-271526-14nfqusv 306 61 association association NN cord-271526-14nfqusv 306 62 of of IN cord-271526-14nfqusv 306 63 a a DT cord-271526-14nfqusv 306 64 Acids Acids NNPS cord-271526-14nfqusv 306 65 Res Res NNP cord-271526-14nfqusv 306 66 Cascoronavirus Cascoronavirus NNP cord-271526-14nfqusv 306 67 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 306 68 protein protein NN cord-271526-14nfqusv 306 69 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 306 70 protein protein NN cord-271526-14nfqusv 306 71 and and CC cord-271526-14nfqusv 306 72 viral viral JJ cord-271526-14nfqusv 306 73 RNAs rna NNS cord-271526-14nfqusv 306 74 : : : cord-271526-14nfqusv 306 75 Implications implication NNS cord-271526-14nfqusv 306 76 for for IN cord-271526-14nfqusv 306 77 viral viral JJ cord-271526-14nfqusv 306 78 transcrip transcrip NNP cord-271526-14nfqusv 306 79 - - HYPH cord-271526-14nfqusv 306 80 Primary primary JJ cord-271526-14nfqusv 306 81 structure structure NN cord-271526-14nfqusv 306 82 and and CC cord-271526-14nfqusv 306 83 translation translation NN cord-271526-14nfqusv 306 84 of of IN cord-271526-14nfqusv 306 85 a a DT cord-271526-14nfqusv 306 86 defective defective JJ cord-271526-14nfqusv 306 87 interfering interfere VBG cord-271526-14nfqusv 306 88 RNA RNA NNP cord-271526-14nfqusv 306 89 of of IN cord-271526-14nfqusv 306 90 tion tion NNP cord-271526-14nfqusv 306 91 Localization Localization NNP cord-271526-14nfqusv 306 92 of of IN cord-271526-14nfqusv 306 93 an an DT cord-271526-14nfqusv 306 94 RNA rna NN cord-271526-14nfqusv 306 95 - - HYPH cord-271526-14nfqusv 306 96 binding bind VBG cord-271526-14nfqusv 306 97 domain domain NN cord-271526-14nfqusv 306 98 in in IN cord-271526-14nfqusv 306 99 the the DT cord-271526-14nfqusv 306 100 minantsin minantsin NN cord-271526-14nfqusv 306 101 the the DT cord-271526-14nfqusv 306 102 interaction interaction NN cord-271526-14nfqusv 306 103 between between IN cord-271526-14nfqusv 306 104 the the DT cord-271526-14nfqusv 306 105 RNA RNA NNP cord-271526-14nfqusv 306 106 encapsidation encapsidation NN cord-271526-14nfqusv 306 107 signal signal NN cord-271526-14nfqusv 306 108 and and CC cord-271526-14nfqusv 306 109 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 306 110 protein protein NN cord-271526-14nfqusv 306 111 of of IN cord-271526-14nfqusv 306 112 the the DT cord-271526-14nfqusv 306 113 coronavirus coronavirus NN cord-271526-14nfqusv 306 114 mouse mouse NN cord-271526-14nfqusv 306 115 hepatitis hepatitis NN cord-271526-14nfqusv 306 116 virus virus NN cord-271526-14nfqusv 306 117 . . . cord-271526-14nfqusv 307 1 Arch Arch NNP cord-271526-14nfqusv 307 2 . . . cord-271526-14nfqusv 308 1 reverse reverse JJ cord-271526-14nfqusv 308 2 transcriptase transcriptase NN cord-271526-14nfqusv 308 3 of of IN cord-271526-14nfqusv 308 4 avian avian JJ cord-271526-14nfqusv 308 5 hepatitis hepatitis NN cord-271526-14nfqusv 308 6 B B NNP cord-271526-14nfqusv 308 7 viruses virus NNS cord-271526-14nfqusv 309 1 Retrovimain Retrovimain NNP cord-271526-14nfqusv 309 2 at at IN cord-271526-14nfqusv 309 3 the the DT cord-271526-14nfqusv 309 4 3 3 CD cord-271526-14nfqusv 309 5 end end NN cord-271526-14nfqusv 309 6 of of IN cord-271526-14nfqusv 309 7 the the DT cord-271526-14nfqusv 309 8 polymerase polymerase NN cord-271526-14nfqusv 309 9 gene gene NN cord-271526-14nfqusv 309 10 is be VBZ cord-271526-14nfqusv 309 11 essential essential JJ cord-271526-14nfqusv 309 12 for for IN cord-271526-14nfqusv 309 13 encapsidaral encapsidaral NNP cord-271526-14nfqusv 309 14 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 309 15 domains domain NNS cord-271526-14nfqusv 309 16 mediate mediate VBP cord-271526-14nfqusv 309 17 the the DT cord-271526-14nfqusv 309 18 specific specific JJ cord-271526-14nfqusv 309 19 recognition recognition NN cord-271526-14nfqusv 309 20 of of IN cord-271526-14nfqusv 309 21 genotion genotion NN cord-271526-14nfqusv 309 22 of of IN cord-271526-14nfqusv 309 23 coronavirus coronavirus NN cord-271526-14nfqusv 309 24 defective defective JJ cord-271526-14nfqusv 309 25 interfering interfere VBG cord-271526-14nfqusv 309 26 RNAs rna NNS cord-271526-14nfqusv 309 27 Virus Virus NNP cord-271526-14nfqusv 309 28 Taxonomy Taxonomy NNP cord-271526-14nfqusv 309 29 , , , cord-271526-14nfqusv 309 30 Classification Classification NNP cord-271526-14nfqusv 309 31 and and CC cord-271526-14nfqusv 309 32 Nomenclature Nomenclature NNP cord-271526-14nfqusv 309 33 of of IN cord-271526-14nfqusv 309 34 Viruses virus NNS cord-271526-14nfqusv 309 35 binding bind VBG cord-271526-14nfqusv 309 36 domain domain NN cord-271526-14nfqusv 309 37 of of IN cord-271526-14nfqusv 309 38 mouse mouse NN cord-271526-14nfqusv 309 39 hepatitis hepatitis NNP cord-271526-14nfqusv 309 40 virus virus NN cord-271526-14nfqusv 309 41 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 309 42 protein protein NNP cord-271526-14nfqusv 309 43 . . . cord-271526-14nfqusv 310 1 J. J. NNP cord-271526-14nfqusv 310 2 Synthesis Synthesis NNP cord-271526-14nfqusv 310 3 and and CC cord-271526-14nfqusv 310 4 subcellular subcellular JJ cord-271526-14nfqusv 310 5 localization localization NN cord-271526-14nfqusv 310 6 of of IN cord-271526-14nfqusv 310 7 the the DT cord-271526-14nfqusv 310 8 murine murine JJ cord-271526-14nfqusv 310 9 coronavirus coronavirus NN cord-271526-14nfqusv 310 10 nu nu NNP cord-271526-14nfqusv 310 11 - - HYPH cord-271526-14nfqusv 310 12 Gen Gen NNP cord-271526-14nfqusv 310 13 and and CC cord-271526-14nfqusv 310 14 sindbis sindbis NNP cord-271526-14nfqusv 310 15 virus virus NN cord-271526-14nfqusv 310 16 nucleocapsid nucleocapsid NNP cord-271526-14nfqusv 310 17 protein protein NN cord-271526-14nfqusv 310 18 that that WDT cord-271526-14nfqusv 310 19 is be VBZ cord-271526-14nfqusv 310 20 involved involve VBN cord-271526-14nfqusv 310 21 in in IN cord-271526-14nfqusv 310 22 specificity specificity NN cord-271526-14nfqusv 310 23 of of IN cord-271526-14nfqusv 310 24 Deans Deans NNP cord-271526-14nfqusv 310 25 Phosphoproteins Phosphoproteins NNP cord-271526-14nfqusv 310 26 of of IN cord-271526-14nfqusv 310 27 murine murine JJ cord-271526-14nfqusv 310 28 N n CD cord-271526-14nfqusv 310 29 genes gene NNS cord-271526-14nfqusv 310 30 of of IN cord-271526-14nfqusv 310 31 five five CD cord-271526-14nfqusv 310 32 strains strain NNS cord-271526-14nfqusv 310 33 of of IN cord-271526-14nfqusv 310 34 the the DT cord-271526-14nfqusv 310 35 coronavirus coronavirus NN cord-271526-14nfqusv 310 36 mouse mouse NN cord-271526-14nfqusv 310 37 hepatitis hepatitis NN cord-271526-14nfqusv 310 38 virus virus NN cord-271526-14nfqusv 310 39 hepatitis hepatitis NN cord-271526-14nfqusv 310 40 viruses virus NNS cord-271526-14nfqusv 310 41 Relikely relikely RB cord-271526-14nfqusv 310 42 to to TO cord-271526-14nfqusv 310 43 be be VB cord-271526-14nfqusv 310 44 required require VBN cord-271526-14nfqusv 310 45 for for IN cord-271526-14nfqusv 310 46 avian avian JJ cord-271526-14nfqusv 310 47 retroviral retroviral NN cord-271526-14nfqusv 310 48 packaging package VBG cord-271526-14nfqusv 310 49 The the DT cord-271526-14nfqusv 310 50 navirus navirus JJ cord-271526-14nfqusv 310 51 envelope envelope NN cord-271526-14nfqusv 310 52 glycoproteins glycoprotein NNS cord-271526-14nfqusv 310 53 and and CC cord-271526-14nfqusv 310 54 interaction interaction NN cord-271526-14nfqusv 310 55 with with IN cord-271526-14nfqusv 310 56 the the DT cord-271526-14nfqusv 310 57 viral viral JJ cord-271526-14nfqusv 310 58 nucleotransmissible nucleotransmissible JJ cord-271526-14nfqusv 310 59 gastroenteritis gastroenteritis NN cord-271526-14nfqusv 310 60 coronavirus coronavirus NN cord-271526-14nfqusv 310 61 contains contain VBZ cord-271526-14nfqusv 310 62 a a DT cord-271526-14nfqusv 310 63 spherical spherical JJ cord-271526-14nfqusv 310 64 core core NN cord-271526-14nfqusv 310 65 capsid capsid NN cord-271526-14nfqusv 310 66 Antigenic antigenic JJ cord-271526-14nfqusv 310 67 variation variation NN cord-271526-14nfqusv 310 68 among among IN cord-271526-14nfqusv 310 69 Molecular molecular JJ cord-271526-14nfqusv 310 70 Cloning cloning NN cord-271526-14nfqusv 310 71 : : : cord-271526-14nfqusv 310 72 murine murine JJ cord-271526-14nfqusv 310 73 coronaviruses coronaviruse NNS cord-271526-14nfqusv 310 74 : : : cord-271526-14nfqusv 310 75 Evidence evidence NN cord-271526-14nfqusv 310 76 for for IN cord-271526-14nfqusv 310 77 polymorphism polymorphism NN cord-271526-14nfqusv 310 78 on on IN cord-271526-14nfqusv 310 79 the the DT cord-271526-14nfqusv 310 80 peplomer peplomer NNP cord-271526-14nfqusv 310 81 A A NNP cord-271526-14nfqusv 310 82 Laboratory Laboratory NNP cord-271526-14nfqusv 310 83 Manual Manual NNP cord-271526-14nfqusv 310 84 Nucleocapsidelements Nucleocapsidelements NNP cord-271526-14nfqusv 310 85 and and CC cord-271526-14nfqusv 310 86 trans trans JJ cord-271526-14nfqusv 310 87 - - JJ cord-271526-14nfqusv 310 88 acting acting JJ cord-271526-14nfqusv 310 89 proteins protein NNS cord-271526-14nfqusv 310 90 involved involve VBN cord-271526-14nfqusv 310 91 in in IN cord-271526-14nfqusv 310 92 the the DT cord-271526-14nfqusv 310 93 assembly assembly NN cord-271526-14nfqusv 310 94 of of IN cord-271526-14nfqusv 310 95 RNA RNA NNP cord-271526-14nfqusv 310 96 independent independent JJ cord-271526-14nfqusv 310 97 assembly assembly NN cord-271526-14nfqusv 310 98 of of IN cord-271526-14nfqusv 310 99 coronavirus coronavirus NN cord-271526-14nfqusv 310 100 - - HYPH cord-271526-14nfqusv 310 101 like like JJ cord-271526-14nfqusv 310 102 particles particle NNS cord-271526-14nfqusv 310 103 by by IN cord-271526-14nfqusv 310 104 co co JJ cord-271526-14nfqusv 310 105 - - JJ cord-271526-14nfqusv 310 106 expression expression NN cord-271526-14nfqusv 310 107 viruses virus NNS cord-271526-14nfqusv 311 1 The the DT cord-271526-14nfqusv 311 2 arterivirus arterivirus NN cord-271526-14nfqusv 311 3 Nsp4 Nsp4 NNP cord-271526-14nfqusv 311 4 protease protease NN cord-271526-14nfqusv 311 5 is be VBZ cord-271526-14nfqusv 311 6 the the DT cord-271526-14nfqusv 311 7 protofor protofor JJ cord-271526-14nfqusv 311 8 specificity specificity NN cord-271526-14nfqusv 311 9 in in IN cord-271526-14nfqusv 311 10 the the DT cord-271526-14nfqusv 311 11 encapsidation encapsidation NN cord-271526-14nfqusv 311 12 of of IN cord-271526-14nfqusv 311 13 Sindbis Sindbis NNP cord-271526-14nfqusv 311 14 virus virus NN cord-271526-14nfqusv 311 15 RNAs RNAs NNP cord-271526-14nfqusv 311 16 cis cis NNP cord-271526-14nfqusv 311 17 - - HYPH cord-271526-14nfqusv 311 18 Acting Acting NNP cord-271526-14nfqusv 311 19 RNA RNA NNP cord-271526-14nfqusv 311 20 packaging packaging NN cord-271526-14nfqusv 311 21 action action NN cord-271526-14nfqusv 311 22 between between IN cord-271526-14nfqusv 311 23 RNA RNA NNP cord-271526-14nfqusv 311 24 phage phage NN cord-271526-14nfqusv 311 25 coat coat NN cord-271526-14nfqusv 311 26 proteins protein NNS cord-271526-14nfqusv 311 27 and and CC cord-271526-14nfqusv 311 28 RNA RNA NNP cord-271526-14nfqusv 311 29 . . . cord-271526-14nfqusv 312 1 Prog Prog NNP cord-271526-14nfqusv 312 2 . . . cord-271526-14nfqusv 313 1 Nucleic nucleic JJ cord-271526-14nfqusv 313 2 locus locus NN cord-271526-14nfqusv 313 3 in in IN cord-271526-14nfqusv 313 4 the the DT cord-271526-14nfqusv 313 5 115-nucleotide 115-nucleotide CD cord-271526-14nfqusv 313 6 direct direct JJ cord-271526-14nfqusv 313 7 repeat repeat NN cord-271526-14nfqusv 313 8 of of IN cord-271526-14nfqusv 313 9 Rous rous JJ cord-271526-14nfqusv 313 10 sarcoma sarcoma NN cord-271526-14nfqusv 313 11 virus virus NN cord-271526-14nfqusv 313 12 Nucleocapsid Nucleocapsid NNP cord-271526-14nfqusv 313 13 protein protein NN cord-271526-14nfqusv 313 14 effects effect NNS cord-271526-14nfqusv 313 15 on on IN cord-271526-14nfqusv 313 16 the the DT cord-271526-14nfqusv 313 17 424 424 CD cord-271526-14nfqusv 313 18 - - SYM cord-271526-14nfqusv 313 19 434 434 CD cord-271526-14nfqusv 313 20 . . . cord-271526-14nfqusv 314 1 specificity specificity NN cord-271526-14nfqusv 314 2 of of IN cord-271526-14nfqusv 314 3 retrovirus retrovirus NN cord-271526-14nfqusv 314 4 RNA RNA NNP cord-271526-14nfqusv 314 5 encapsidation encapsidation NN cord-271526-14nfqusv 315 1 The the DT cord-271526-14nfqusv 315 2 infectious infectious JJ cord-271526-14nfqusv 315 3 bronchitis bronchitis NN cord-271526-14nfqusv 315 4 virus virus NN cord-271526-14nfqusv 315 5 nucleocapsid nucleocapsid NN cord-271526-14nfqusv 315 6 protein protein NN cord-271526-14nfqusv 315 7 binds bind VBZ cord-271526-14nfqusv 315 8 navirus navirus NNP cord-271526-14nfqusv 315 9 mRNA mRNA NNP cord-271526-14nfqusv 315 10 synthesis synthesis NNP cord-271526-14nfqusv 315 11 involves involve VBZ cord-271526-14nfqusv 315 12 fusion fusion NN cord-271526-14nfqusv 315 13 of of IN cord-271526-14nfqusv 315 14 non non JJ cord-271526-14nfqusv 315 15 - - JJ cord-271526-14nfqusv 315 16 contiguous contiguous JJ cord-271526-14nfqusv 315 17 se se FW cord-271526-14nfqusv 315 18 - - HYPH cord-271526-14nfqusv 315 19 RNA RNA NNP cord-271526-14nfqusv 315 20 sequences sequence NNS cord-271526-14nfqusv 315 21 in in IN cord-271526-14nfqusv 315 22 the the DT cord-271526-14nfqusv 315 23 3 3 CD cord-271526-14nfqusv 315 24 terminus terminus NN cord-271526-14nfqusv 315 25 of of IN cord-271526-14nfqusv 315 26 the the DT cord-271526-14nfqusv 315 27 genome genome NN