id	sid	tid	token	lemma	pos
cord-272051-arz8r204	1	1	key	key	NN
cord-272051-arz8r204	1	2	:	:	:
cord-272051-arz8r204	2	1	cord-272051-arz8r204	cord-272051-arz8r204	NNP
cord-272051-arz8r204	3	1	authors	author	NNS
cord-272051-arz8r204	3	2	:	:	:
cord-272051-arz8r204	3	3	Federico	Federico	NNP
cord-272051-arz8r204	3	4	,	,	,
cord-272051-arz8r204	4	1	Maurizio	Maurizio	NNP
cord-272051-arz8r204	4	2	title	title	NN
cord-272051-arz8r204	4	3	:	:	:
cord-272051-arz8r204	5	1	HIV	HIV	NNP
cord-272051-arz8r204	5	2	-	-	HYPH
cord-272051-arz8r204	5	3	protease	protease	NN
cord-272051-arz8r204	5	4	inhibitors	inhibitor	NNS
cord-272051-arz8r204	5	5	block	block	VBP
cord-272051-arz8r204	5	6	the	the	DT
cord-272051-arz8r204	5	7	replication	replication	NN
cord-272051-arz8r204	5	8	of	of	IN
cord-272051-arz8r204	5	9	both	both	DT
cord-272051-arz8r204	5	10	vesicular	vesicular	JJ
cord-272051-arz8r204	5	11	stomatitis	stomatitis	NN
cord-272051-arz8r204	5	12	and	and	CC
cord-272051-arz8r204	5	13	influenza	influenza	NN
cord-272051-arz8r204	5	14	viruses	virus	NNS
cord-272051-arz8r204	5	15	at	at	IN
cord-272051-arz8r204	5	16	an	an	DT
cord-272051-arz8r204	5	17	early	early	JJ
cord-272051-arz8r204	5	18	post	post	JJ
cord-272051-arz8r204	5	19	-	-	JJ
cord-272051-arz8r204	5	20	entry	entry	JJ
cord-272051-arz8r204	5	21	replication	replication	NN
cord-272051-arz8r204	5	22	step	step	NN
cord-272051-arz8r204	5	23	date	date	NN
cord-272051-arz8r204	6	1	:	:	:
cord-272051-arz8r204	6	2	2011	2011	CD
cord-272051-arz8r204	6	3	-	-	SYM
cord-272051-arz8r204	6	4	08	08	CD
cord-272051-arz8r204	6	5	-	-	SYM
cord-272051-arz8r204	6	6	15	15	CD
cord-272051-arz8r204	6	7	journal	journal	NN
cord-272051-arz8r204	6	8	:	:	:
cord-272051-arz8r204	7	1	Virology	virology	NN
cord-272051-arz8r204	7	2	DOI	DOI	NNP
cord-272051-arz8r204	7	3	:	:	:
cord-272051-arz8r204	8	1	10.1016	10.1016	CD
cord-272051-arz8r204	8	2	/	/	SYM
cord-272051-arz8r204	8	3	j.virol.2011.05.002	j.virol.2011.05.002	CD
cord-272051-arz8r204	8	4	sha	sha	NN
cord-272051-arz8r204	8	5	:	:	:
cord-272051-arz8r204	8	6	c5ec12f3c8fb53fc9c4534abc546da1c8aeaccef	c5ec12f3c8fb53fc9c4534abc546da1c8aeaccef	CD
cord-272051-arz8r204	8	7	doc_id	doc_id	CD
cord-272051-arz8r204	8	8	:	:	:
cord-272051-arz8r204	8	9	272051	272051	CD
cord-272051-arz8r204	8	10	cord_uid	cord_uid	NNS
cord-272051-arz8r204	8	11	:	:	:
cord-272051-arz8r204	9	1	arz8r204	arz8r204	NNP
cord-272051-arz8r204	10	1	The	the	DT
cord-272051-arz8r204	10	2	inhibitors	inhibitor	NNS
cord-272051-arz8r204	10	3	of	of	IN
cord-272051-arz8r204	10	4	HIV-1	HIV-1	NNP
cord-272051-arz8r204	10	5	protease	protease	NN
cord-272051-arz8r204	10	6	(	(	-LRB-
cord-272051-arz8r204	10	7	PIs	pi	NNS
cord-272051-arz8r204	10	8	)	)	-RRB-
cord-272051-arz8r204	10	9	have	have	VBP
cord-272051-arz8r204	10	10	been	be	VBN
cord-272051-arz8r204	10	11	designed	design	VBN
cord-272051-arz8r204	10	12	to	to	TO
cord-272051-arz8r204	10	13	block	block	VB
cord-272051-arz8r204	10	14	the	the	DT
cord-272051-arz8r204	10	15	activity	activity	NN
cord-272051-arz8r204	10	16	of	of	IN
cord-272051-arz8r204	10	17	the	the	DT
cord-272051-arz8r204	10	18	viral	viral	JJ
cord-272051-arz8r204	10	19	aspartyl	aspartyl	NN
cord-272051-arz8r204	10	20	-	-	HYPH
cord-272051-arz8r204	10	21	protease	protease	NN
cord-272051-arz8r204	10	22	.	.	.
cord-272051-arz8r204	11	1	However	however	RB
cord-272051-arz8r204	11	2	,	,	,
cord-272051-arz8r204	11	3	it	-PRON-	PRP
cord-272051-arz8r204	11	4	is	be	VBZ
cord-272051-arz8r204	11	5	now	now	RB
cord-272051-arz8r204	11	6	accepted	accept	VBN
cord-272051-arz8r204	11	7	that	that	IN
cord-272051-arz8r204	11	8	this	this	DT
cord-272051-arz8r204	11	9	family	family	NN
cord-272051-arz8r204	11	10	of	of	IN
cord-272051-arz8r204	11	11	inhibitors	inhibitor	NNS
cord-272051-arz8r204	11	12	can	can	MD
cord-272051-arz8r204	11	13	also	also	RB
cord-272051-arz8r204	11	14	affect	affect	VB
cord-272051-arz8r204	11	15	the	the	DT
cord-272051-arz8r204	11	16	activity	activity	NN
cord-272051-arz8r204	11	17	of	of	IN
cord-272051-arz8r204	11	18	cell	cell	NN
cord-272051-arz8r204	11	19	proteases	protease	NNS
cord-272051-arz8r204	11	20	.	.	.
cord-272051-arz8r204	12	1	Since	since	IN
cord-272051-arz8r204	12	2	the	the	DT
cord-272051-arz8r204	12	3	replication	replication	NN
cord-272051-arz8r204	12	4	of	of	IN
cord-272051-arz8r204	12	5	many	many	JJ
cord-272051-arz8r204	12	6	virus	virus	NN
cord-272051-arz8r204	12	7	species	species	NN
cord-272051-arz8r204	12	8	requires	require	VBZ
cord-272051-arz8r204	12	9	the	the	DT
cord-272051-arz8r204	12	10	activity	activity	NN
cord-272051-arz8r204	12	11	of	of	IN
cord-272051-arz8r204	12	12	host	host	NN
cord-272051-arz8r204	12	13	cell	cell	NN
cord-272051-arz8r204	12	14	proteases	protease	NNS
cord-272051-arz8r204	12	15	,	,	,
cord-272051-arz8r204	12	16	investigating	investigate	VBG
cord-272051-arz8r204	12	17	the	the	DT
cord-272051-arz8r204	12	18	effects	effect	NNS
cord-272051-arz8r204	12	19	of	of	IN
cord-272051-arz8r204	12	20	PIs	pi	NNS
cord-272051-arz8r204	12	21	on	on	IN
cord-272051-arz8r204	12	22	the	the	DT
cord-272051-arz8r204	12	23	life	life	NN
cord-272051-arz8r204	12	24	cycle	cycle	NN
cord-272051-arz8r204	12	25	of	of	IN
cord-272051-arz8r204	12	26	viruses	virus	NNS
cord-272051-arz8r204	12	27	other	other	JJ
cord-272051-arz8r204	12	28	than	than	IN
cord-272051-arz8r204	12	29	HIV	HIV	NNP
cord-272051-arz8r204	12	30	would	would	MD
cord-272051-arz8r204	12	31	be	be	VB
cord-272051-arz8r204	12	32	of	of	IN
cord-272051-arz8r204	12	33	interest	interest	NN
cord-272051-arz8r204	12	34	.	.	.
cord-272051-arz8r204	13	1	Here	here	RB
cord-272051-arz8r204	13	2	,	,	,
cord-272051-arz8r204	13	3	the	the	DT
cord-272051-arz8r204	13	4	potent	potent	JJ
cord-272051-arz8r204	13	5	inhibition	inhibition	NN
cord-272051-arz8r204	13	6	induced	induce	VBN
cord-272051-arz8r204	13	7	by	by	IN
cord-272051-arz8r204	13	8	saquinavir	saquinavir	NNP
cord-272051-arz8r204	13	9	and	and	CC
cord-272051-arz8r204	13	10	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	13	11	on	on	IN
cord-272051-arz8r204	13	12	the	the	DT
cord-272051-arz8r204	13	13	replication	replication	NN
cord-272051-arz8r204	13	14	of	of	IN
cord-272051-arz8r204	13	15	both	both	DT
cord-272051-arz8r204	13	16	vesicular	vesicular	JJ
cord-272051-arz8r204	13	17	stomatitis	stomatitis	NN
cord-272051-arz8r204	13	18	and	and	CC
cord-272051-arz8r204	13	19	influenza	influenza	NN
cord-272051-arz8r204	13	20	viruses	virus	NNS
cord-272051-arz8r204	13	21	is	be	VBZ
cord-272051-arz8r204	13	22	described	describe	VBN
cord-272051-arz8r204	13	23	.	.	.
cord-272051-arz8r204	14	1	These	these	DT
cord-272051-arz8r204	14	2	are	be	VBP
cord-272051-arz8r204	14	3	unrelated	unrelated	JJ
cord-272051-arz8r204	14	4	enveloped	envelop	VBN
cord-272051-arz8r204	14	5	RNA	RNA	NNP
cord-272051-arz8r204	14	6	viruses	virus	NNS
cord-272051-arz8r204	14	7	infecting	infect	VBG
cord-272051-arz8r204	14	8	target	target	NN
cord-272051-arz8r204	14	9	cells	cell	NNS
cord-272051-arz8r204	14	10	upon	upon	IN
cord-272051-arz8r204	14	11	endocytosis	endocytosis	NN
cord-272051-arz8r204	14	12	and	and	CC
cord-272051-arz8r204	14	13	intracellular	intracellular	JJ
cord-272051-arz8r204	14	14	fusion	fusion	NN
cord-272051-arz8r204	14	15	.	.	.
cord-272051-arz8r204	15	1	The	the	DT
cord-272051-arz8r204	15	2	PI	pi	NN
cord-272051-arz8r204	15	3	-	-	HYPH
cord-272051-arz8r204	15	4	induced	induce	VBN
cord-272051-arz8r204	15	5	inhibition	inhibition	NN
cord-272051-arz8r204	15	6	was	be	VBD
cord-272051-arz8r204	15	7	apparently	apparently	RB
cord-272051-arz8r204	15	8	a	a	DT
cord-272051-arz8r204	15	9	consequence	consequence	NN
cord-272051-arz8r204	15	10	of	of	IN
cord-272051-arz8r204	15	11	a	a	DT
cord-272051-arz8r204	15	12	block	block	NN
cord-272051-arz8r204	15	13	at	at	IN
cord-272051-arz8r204	15	14	the	the	DT
cord-272051-arz8r204	15	15	level	level	NN
cord-272051-arz8r204	15	16	of	of	IN
cord-272051-arz8r204	15	17	the	the	DT
cord-272051-arz8r204	15	18	fusion	fusion	NN
cord-272051-arz8r204	15	19	between	between	IN
cord-272051-arz8r204	15	20	viral	viral	JJ
cord-272051-arz8r204	15	21	envelope	envelope	NN
cord-272051-arz8r204	15	22	and	and	CC
cord-272051-arz8r204	15	23	endosomal	endosomal	NNP
cord-272051-arz8r204	15	24	membranes	membrane	NNS
cord-272051-arz8r204	15	25	.	.	.
cord-272051-arz8r204	16	1	These	these	DT
cord-272051-arz8r204	16	2	findings	finding	NNS
cord-272051-arz8r204	16	3	would	would	MD
cord-272051-arz8r204	16	4	open	open	VB
cord-272051-arz8r204	16	5	the	the	DT
cord-272051-arz8r204	16	6	way	way	NN
cord-272051-arz8r204	16	7	towards	towards	IN
cord-272051-arz8r204	16	8	the	the	DT
cord-272051-arz8r204	16	9	therapeutic	therapeutic	JJ
cord-272051-arz8r204	16	10	use	use	NN
cord-272051-arz8r204	16	11	of	of	IN
cord-272051-arz8r204	16	12	PIs	pi	NNS
cord-272051-arz8r204	16	13	against	against	IN
cord-272051-arz8r204	16	14	enveloped	envelop	VBN
cord-272051-arz8r204	16	15	RNA	RNA	NNP
cord-272051-arz8r204	16	16	viruses	virus	NNS
cord-272051-arz8r204	16	17	other	other	JJ
cord-272051-arz8r204	16	18	than	than	IN
cord-272051-arz8r204	16	19	HIV	HIV	NNP
cord-272051-arz8r204	16	20	.	.	.
cord-272051-arz8r204	17	1	HIV	HIV	NNP
cord-272051-arz8r204	17	2	protease	protease	NN
cord-272051-arz8r204	17	3	inhibitors	inhibitor	NNS
cord-272051-arz8r204	17	4	(	(	-LRB-
cord-272051-arz8r204	17	5	PIs	pi	NNS
cord-272051-arz8r204	17	6	)	)	-RRB-
cord-272051-arz8r204	17	7	are	be	VBP
cord-272051-arz8r204	17	8	a	a	DT
cord-272051-arz8r204	17	9	family	family	NN
cord-272051-arz8r204	17	10	of	of	IN
cord-272051-arz8r204	17	11	small	small	JJ
cord-272051-arz8r204	17	12	molecules	molecule	NNS
cord-272051-arz8r204	17	13	specifically	specifically	RB
cord-272051-arz8r204	17	14	designed	design	VBN
cord-272051-arz8r204	17	15	for	for	IN
cord-272051-arz8r204	17	16	blocking	block	VBG
cord-272051-arz8r204	17	17	the	the	DT
cord-272051-arz8r204	17	18	activity	activity	NN
cord-272051-arz8r204	17	19	of	of	IN
cord-272051-arz8r204	17	20	the	the	DT
cord-272051-arz8r204	17	21	HIV	HIV	NNP
cord-272051-arz8r204	17	22	aspartylprotease	aspartylprotease	NN
cord-272051-arz8r204	17	23	(	(	-LRB-
cord-272051-arz8r204	17	24	for	for	IN
cord-272051-arz8r204	17	25	a	a	DT
cord-272051-arz8r204	17	26	review	review	NN
cord-272051-arz8r204	17	27	,	,	,
cord-272051-arz8r204	17	28	see	see	VB
cord-272051-arz8r204	17	29	Flexner	Flexner	NNP
cord-272051-arz8r204	17	30	,	,	,
cord-272051-arz8r204	17	31	1998	1998	CD
cord-272051-arz8r204	17	32	)	)	-RRB-
cord-272051-arz8r204	17	33	.	.	.
cord-272051-arz8r204	18	1	The	the	DT
cord-272051-arz8r204	18	2	PI	pi	NN
cord-272051-arz8r204	18	3	treatment	treatment	NN
cord-272051-arz8r204	18	4	leads	lead	VBZ
cord-272051-arz8r204	18	5	to	to	IN
cord-272051-arz8r204	18	6	the	the	DT
cord-272051-arz8r204	18	7	block	block	NN
cord-272051-arz8r204	18	8	of	of	IN
cord-272051-arz8r204	18	9	HIV	HIV	NNP
cord-272051-arz8r204	18	10	maturation	maturation	NN
cord-272051-arz8r204	18	11	with	with	IN
cord-272051-arz8r204	18	12	consequent	consequent	JJ
cord-272051-arz8r204	18	13	release	release	NN
cord-272051-arz8r204	18	14	of	of	IN
cord-272051-arz8r204	18	15	noninfectious	noninfectious	JJ
cord-272051-arz8r204	18	16	viral	viral	JJ
cord-272051-arz8r204	18	17	particles	particle	NNS
cord-272051-arz8r204	18	18	(	(	-LRB-
cord-272051-arz8r204	18	19	Kaplan	Kaplan	NNP
cord-272051-arz8r204	18	20	et	et	NNP
cord-272051-arz8r204	18	21	al	al	NNP
cord-272051-arz8r204	18	22	.	.	NNP
cord-272051-arz8r204	18	23	,	,	,
cord-272051-arz8r204	18	24	1993	1993	CD
cord-272051-arz8r204	18	25	)	)	-RRB-
cord-272051-arz8r204	18	26	.	.	.
cord-272051-arz8r204	19	1	PIs	pi	NNS
cord-272051-arz8r204	19	2	exert	exert	VBP
cord-272051-arz8r204	19	3	their	-PRON-	PRP$
cord-272051-arz8r204	19	4	inhibitory	inhibitory	JJ
cord-272051-arz8r204	19	5	effect	effect	NN
cord-272051-arz8r204	19	6	by	by	IN
cord-272051-arz8r204	19	7	disabling	disable	VBG
cord-272051-arz8r204	19	8	the	the	DT
cord-272051-arz8r204	19	9	enzyme	enzyme	NN
cord-272051-arz8r204	19	10	before	before	IN
cord-272051-arz8r204	19	11	it	-PRON-	PRP
cord-272051-arz8r204	19	12	can	can	MD
cord-272051-arz8r204	19	13	cleave	cleave	VB
cord-272051-arz8r204	19	14	the	the	DT
cord-272051-arz8r204	19	15	Gag	Gag	NNP
cord-272051-arz8r204	19	16	-	-	HYPH
cord-272051-arz8r204	19	17	Pol	Pol	NNP
cord-272051-arz8r204	19	18	polyprotein	polyprotein	NN
cord-272051-arz8r204	19	19	into	into	IN
cord-272051-arz8r204	19	20	its	-PRON-	PRP$
cord-272051-arz8r204	19	21	essential	essential	JJ
cord-272051-arz8r204	19	22	products	product	NNS
cord-272051-arz8r204	19	23	.	.	.
cord-272051-arz8r204	20	1	PIs	PIs	NNP
cord-272051-arz8r204	20	2	,	,	,
cord-272051-arz8r204	20	3	together	together	RB
cord-272051-arz8r204	20	4	with	with	IN
cord-272051-arz8r204	20	5	anti	anti	JJ
cord-272051-arz8r204	20	6	-	-	JJ
cord-272051-arz8r204	20	7	HIV	hiv	JJ
cord-272051-arz8r204	20	8	compounds	compound	NNS
cord-272051-arz8r204	20	9	targeting	target	VBG
cord-272051-arz8r204	20	10	alternative	alternative	JJ
cord-272051-arz8r204	20	11	steps	step	NNS
cord-272051-arz8r204	20	12	of	of	IN
cord-272051-arz8r204	20	13	the	the	DT
cord-272051-arz8r204	20	14	virus	virus	NN
cord-272051-arz8r204	20	15	life	life	NN
cord-272051-arz8r204	20	16	cycle	cycle	NN
cord-272051-arz8r204	20	17	,	,	,
cord-272051-arz8r204	20	18	are	be	VBP
cord-272051-arz8r204	20	19	part	part	NN
cord-272051-arz8r204	20	20	of	of	IN
cord-272051-arz8r204	20	21	the	the	DT
cord-272051-arz8r204	20	22	most	most	RBS
cord-272051-arz8r204	20	23	advanced	advanced	JJ
cord-272051-arz8r204	20	24	anti	anti	JJ
cord-272051-arz8r204	20	25	-	-	JJ
cord-272051-arz8r204	20	26	HIV	hiv	JJ
cord-272051-arz8r204	20	27	therapies	therapy	NNS
cord-272051-arz8r204	20	28	allowing	allow	VBG
cord-272051-arz8r204	20	29	millions	million	NNS
cord-272051-arz8r204	20	30	of	of	IN
cord-272051-arz8r204	20	31	infected	infected	JJ
cord-272051-arz8r204	20	32	people	people	NNS
cord-272051-arz8r204	20	33	to	to	TO
cord-272051-arz8r204	20	34	co	co	VB
cord-272051-arz8r204	20	35	-	-	VB
cord-272051-arz8r204	20	36	exist	exist	VB
cord-272051-arz8r204	20	37	with	with	IN
cord-272051-arz8r204	20	38	the	the	DT
cord-272051-arz8r204	20	39	virus	virus	NN
cord-272051-arz8r204	20	40	experiencing	experience	VBG
cord-272051-arz8r204	20	41	a	a	DT
cord-272051-arz8r204	20	42	good	good	JJ
cord-272051-arz8r204	20	43	quality	quality	NN
cord-272051-arz8r204	20	44	of	of	IN
cord-272051-arz8r204	20	45	life	life	NN
cord-272051-arz8r204	20	46	.	.	.
cord-272051-arz8r204	21	1	However	however	RB
cord-272051-arz8r204	21	2	,	,	,
cord-272051-arz8r204	21	3	it	-PRON-	PRP
cord-272051-arz8r204	21	4	is	be	VBZ
cord-272051-arz8r204	21	5	now	now	RB
cord-272051-arz8r204	21	6	clear	clear	JJ
cord-272051-arz8r204	21	7	that	that	IN
cord-272051-arz8r204	21	8	PIs	pis	NN
cord-272051-arz8r204	21	9	can	can	MD
cord-272051-arz8r204	21	10	also	also	RB
cord-272051-arz8r204	21	11	directly	directly	RB
cord-272051-arz8r204	21	12	or	or	CC
cord-272051-arz8r204	21	13	indirectly	indirectly	RB
cord-272051-arz8r204	21	14	inhibit	inhibit	VB
cord-272051-arz8r204	21	15	the	the	DT
cord-272051-arz8r204	21	16	activity	activity	NN
cord-272051-arz8r204	21	17	of	of	IN
cord-272051-arz8r204	21	18	many	many	JJ
cord-272051-arz8r204	21	19	cell	cell	NN
cord-272051-arz8r204	21	20	proteases	protease	NNS
cord-272051-arz8r204	21	21	.	.	.
cord-272051-arz8r204	22	1	In	in	IN
cord-272051-arz8r204	22	2	particular	particular	JJ
cord-272051-arz8r204	22	3	,	,	,
cord-272051-arz8r204	22	4	PIs	pi	NNS
cord-272051-arz8r204	22	5	can	can	MD
cord-272051-arz8r204	22	6	inhibit	inhibit	VB
cord-272051-arz8r204	22	7	the	the	DT
cord-272051-arz8r204	22	8	activity	activity	NN
cord-272051-arz8r204	22	9	of	of	IN
cord-272051-arz8r204	22	10	both	both	DT
cord-272051-arz8r204	22	11	20S	20s	CD
cord-272051-arz8r204	23	1	(	(	-LRB-
cord-272051-arz8r204	23	2	André	André	NNP
cord-272051-arz8r204	23	3	et	et	NNP
cord-272051-arz8r204	23	4	al	al	NNP
cord-272051-arz8r204	23	5	.	.	NNP
cord-272051-arz8r204	23	6	,	,	,
cord-272051-arz8r204	23	7	1998	1998	CD
cord-272051-arz8r204	23	8	)	)	-RRB-
cord-272051-arz8r204	23	9	and	and	CC
cord-272051-arz8r204	23	10	26S	26S	NNP
cord-272051-arz8r204	23	11	(	(	-LRB-
cord-272051-arz8r204	23	12	Pajonk	Pajonk	NNP
cord-272051-arz8r204	23	13	et	et	NNP
cord-272051-arz8r204	23	14	al	al	NNP
cord-272051-arz8r204	23	15	.	.	NNP
cord-272051-arz8r204	23	16	,	,	,
cord-272051-arz8r204	23	17	2002	2002	CD
cord-272051-arz8r204	23	18	)	)	-RRB-
cord-272051-arz8r204	23	19	proteasome	proteasome	NN
cord-272051-arz8r204	23	20	subunits	subunit	NNS
cord-272051-arz8r204	23	21	,	,	,
cord-272051-arz8r204	23	22	as	as	RB
cord-272051-arz8r204	23	23	well	well	RB
cord-272051-arz8r204	23	24	as	as	IN
cord-272051-arz8r204	23	25	that	that	DT
cord-272051-arz8r204	23	26	of	of	IN
cord-272051-arz8r204	23	27	caspases	caspase	NNS
cord-272051-arz8r204	23	28	(	(	-LRB-
cord-272051-arz8r204	23	29	Badley	Badley	NNP
cord-272051-arz8r204	23	30	,	,	,
cord-272051-arz8r204	23	31	2005	2005	CD
cord-272051-arz8r204	23	32	)	)	-RRB-
cord-272051-arz8r204	23	33	,	,	,
cord-272051-arz8r204	23	34	with	with	IN
cord-272051-arz8r204	23	35	alterations	alteration	NNS
cord-272051-arz8r204	23	36	in	in	IN
cord-272051-arz8r204	23	37	the	the	DT
cord-272051-arz8r204	23	38	susceptibility	susceptibility	NN
cord-272051-arz8r204	23	39	to	to	IN
cord-272051-arz8r204	23	40	apoptosis	apoptosis	NN
cord-272051-arz8r204	23	41	stimuli	stimulus	NNS
cord-272051-arz8r204	23	42	.	.	.
cord-272051-arz8r204	24	1	Both	both	DT
cord-272051-arz8r204	24	2	expression	expression	NN
cord-272051-arz8r204	24	3	and	and	CC
cord-272051-arz8r204	24	4	release	release	NN
cord-272051-arz8r204	24	5	of	of	IN
cord-272051-arz8r204	24	6	matrixmetalloproteinases	matrixmetalloproteinase	NNS
cord-272051-arz8r204	24	7	(	(	-LRB-
cord-272051-arz8r204	24	8	MMPs	MMPs	NNP
cord-272051-arz8r204	24	9	)	)	-RRB-
cord-272051-arz8r204	24	10	can	can	MD
cord-272051-arz8r204	24	11	be	be	VB
cord-272051-arz8r204	24	12	also	also	RB
cord-272051-arz8r204	24	13	targeted	target	VBN
cord-272051-arz8r204	24	14	by	by	IN
cord-272051-arz8r204	24	15	PIs	pi	NNS
cord-272051-arz8r204	24	16	(	(	-LRB-
cord-272051-arz8r204	24	17	Bourlier	Bourlier	NNP
cord-272051-arz8r204	24	18	et	et	NNP
cord-272051-arz8r204	24	19	al	al	NNP
cord-272051-arz8r204	24	20	.	.	NNP
cord-272051-arz8r204	24	21	,	,	,
cord-272051-arz8r204	24	22	2005	2005	CD
cord-272051-arz8r204	24	23	;	;	:
cord-272051-arz8r204	24	24	De	De	NNP
cord-272051-arz8r204	24	25	Barros	Barros	NNP
cord-272051-arz8r204	24	26	et	et	NNP
cord-272051-arz8r204	24	27	al	al	NNP
cord-272051-arz8r204	24	28	.	.	NNP
cord-272051-arz8r204	24	29	,	,	,
cord-272051-arz8r204	24	30	2007	2007	CD
cord-272051-arz8r204	24	31	)	)	-RRB-
cord-272051-arz8r204	24	32	with	with	IN
cord-272051-arz8r204	24	33	consequences	consequence	NNS
cord-272051-arz8r204	24	34	in	in	IN
cord-272051-arz8r204	24	35	the	the	DT
cord-272051-arz8r204	24	36	extracellular	extracellular	JJ
cord-272051-arz8r204	24	37	matrix	matrix	NN
cord-272051-arz8r204	24	38	modeling	modeling	NN
cord-272051-arz8r204	24	39	and	and	CC
cord-272051-arz8r204	24	40	,	,	,
cord-272051-arz8r204	24	41	more	more	RBR
cord-272051-arz8r204	24	42	in	in	IN
cord-272051-arz8r204	24	43	general	general	JJ
cord-272051-arz8r204	24	44	,	,	,
cord-272051-arz8r204	24	45	in	in	IN
cord-272051-arz8r204	24	46	the	the	DT
cord-272051-arz8r204	24	47	cell	cell	NN
cord-272051-arz8r204	24	48	-	-	HYPH
cord-272051-arz8r204	24	49	cell	cell	NN
cord-272051-arz8r204	24	50	communication	communication	NN
cord-272051-arz8r204	24	51	.	.	.
cord-272051-arz8r204	25	1	In	in	IN
cord-272051-arz8r204	25	2	addition	addition	NN
cord-272051-arz8r204	25	3	,	,	,
cord-272051-arz8r204	25	4	PIs	pi	NNS
cord-272051-arz8r204	25	5	have	have	VBP
cord-272051-arz8r204	25	6	been	be	VBN
cord-272051-arz8r204	25	7	found	find	VBN
cord-272051-arz8r204	25	8	inhibiting	inhibit	VBG
cord-272051-arz8r204	25	9	cell	cell	NN
cord-272051-arz8r204	25	10	signaling	signal	VBG
cord-272051-arz8r204	25	11	pathway	pathway	NN
cord-272051-arz8r204	25	12	involving	involve	VBG
cord-272051-arz8r204	25	13	both	both	CC
cord-272051-arz8r204	25	14	NF	nf	NN
cord-272051-arz8r204	25	15	-	-	HYPH
cord-272051-arz8r204	25	16	κB	κB	NNP
cord-272051-arz8r204	26	1	(	(	-LRB-
cord-272051-arz8r204	26	2	Dewan	Dewan	NNP
cord-272051-arz8r204	26	3	et	et	NNP
cord-272051-arz8r204	26	4	al	al	NNP
cord-272051-arz8r204	26	5	.	.	NNP
cord-272051-arz8r204	26	6	,	,	,
cord-272051-arz8r204	26	7	2009	2009	CD
cord-272051-arz8r204	26	8	)	)	-RRB-
cord-272051-arz8r204	26	9	and	and	CC
cord-272051-arz8r204	26	10	AKT	AKT	NNP
cord-272051-arz8r204	26	11	(	(	-LRB-
cord-272051-arz8r204	26	12	Kumar	Kumar	NNP
cord-272051-arz8r204	26	13	et	et	NNP
cord-272051-arz8r204	26	14	al	al	NNP
cord-272051-arz8r204	26	15	.	.	NNP
cord-272051-arz8r204	26	16	,	,	,
cord-272051-arz8r204	26	17	2009	2009	CD
cord-272051-arz8r204	26	18	;	;	:
cord-272051-arz8r204	26	19	Srirangam	Srirangam	NNP
cord-272051-arz8r204	26	20	et	et	FW
cord-272051-arz8r204	26	21	al	al	NNP
cord-272051-arz8r204	26	22	.	.	NNP
cord-272051-arz8r204	26	23	,	,	,
cord-272051-arz8r204	26	24	2006	2006	CD
cord-272051-arz8r204	26	25	)	)	-RRB-
cord-272051-arz8r204	26	26	.	.	.
cord-272051-arz8r204	27	1	From	from	IN
cord-272051-arz8r204	27	2	a	a	DT
cord-272051-arz8r204	27	3	clinical	clinical	JJ
cord-272051-arz8r204	27	4	point	point	NN
cord-272051-arz8r204	27	5	of	of	IN
cord-272051-arz8r204	27	6	view	view	NN
cord-272051-arz8r204	27	7	,	,	,
cord-272051-arz8r204	27	8	the	the	DT
cord-272051-arz8r204	27	9	PI	PI	NNP
cord-272051-arz8r204	27	10	treatment	treatment	NN
cord-272051-arz8r204	27	11	may	may	MD
cord-272051-arz8r204	27	12	induce	induce	VB
cord-272051-arz8r204	27	13	beneficial	beneficial	JJ
cord-272051-arz8r204	27	14	effects	effect	NNS
cord-272051-arz8r204	27	15	other	other	JJ
cord-272051-arz8r204	27	16	than	than	IN
cord-272051-arz8r204	27	17	those	those	DT
cord-272051-arz8r204	27	18	against	against	IN
cord-272051-arz8r204	27	19	HIV	HIV	NNP
cord-272051-arz8r204	27	20	,	,	,
cord-272051-arz8r204	27	21	as	as	IN
cord-272051-arz8r204	27	22	in	in	IN
cord-272051-arz8r204	27	23	the	the	DT
cord-272051-arz8r204	27	24	case	case	NN
cord-272051-arz8r204	27	25	of	of	IN
cord-272051-arz8r204	27	26	Kaposi	Kaposi	NNP
cord-272051-arz8r204	27	27	sarcoma	sarcoma	NN
cord-272051-arz8r204	27	28	regression	regression	NN
cord-272051-arz8r204	27	29	(	(	-LRB-
cord-272051-arz8r204	27	30	Sgadari	Sgadari	NNP
cord-272051-arz8r204	27	31	et	et	FW
cord-272051-arz8r204	27	32	al	al	NNP
cord-272051-arz8r204	27	33	.	.	NNP
cord-272051-arz8r204	27	34	,	,	,
cord-272051-arz8r204	27	35	2002	2002	CD
cord-272051-arz8r204	27	36	)	)	-RRB-
cord-272051-arz8r204	27	37	,	,	,
cord-272051-arz8r204	27	38	but	but	CC
cord-272051-arz8r204	27	39	can	can	MD
cord-272051-arz8r204	27	40	also	also	RB
cord-272051-arz8r204	27	41	have	have	VB
cord-272051-arz8r204	27	42	detrimental	detrimental	JJ
cord-272051-arz8r204	27	43	consequences	consequence	NNS
cord-272051-arz8r204	27	44	,	,	,
cord-272051-arz8r204	27	45	as	as	IN
cord-272051-arz8r204	27	46	for	for	IN
cord-272051-arz8r204	27	47	the	the	DT
cord-272051-arz8r204	27	48	dyslipidemia	dyslipidemia	NN
cord-272051-arz8r204	27	49	occurring	occur	VBG
cord-272051-arz8r204	27	50	in	in	IN
cord-272051-arz8r204	27	51	PI	PI	NNP
cord-272051-arz8r204	27	52	-	-	HYPH
cord-272051-arz8r204	27	53	treated	treat	VBN
cord-272051-arz8r204	27	54	HIV	HIV	NNP
cord-272051-arz8r204	27	55	patients	patient	NNS
cord-272051-arz8r204	28	1	(	(	-LRB-
cord-272051-arz8r204	28	2	Calza	Calza	NNP
cord-272051-arz8r204	28	3	et	et	NNP
cord-272051-arz8r204	28	4	al	al	NNP
cord-272051-arz8r204	28	5	.	.	NNP
cord-272051-arz8r204	28	6	,	,	,
cord-272051-arz8r204	28	7	2004	2004	CD
cord-272051-arz8r204	28	8	)	)	-RRB-
cord-272051-arz8r204	28	9	.	.	.
cord-272051-arz8r204	29	1	To	to	TO
cord-272051-arz8r204	29	2	enter	enter	VB
cord-272051-arz8r204	29	3	target	target	NN
cord-272051-arz8r204	29	4	cells	cell	NNS
cord-272051-arz8r204	29	5	,	,	,
cord-272051-arz8r204	29	6	enveloped	envelop	VBD
cord-272051-arz8r204	29	7	RNA	RNA	NNP
cord-272051-arz8r204	29	8	viruses	virus	NNS
cord-272051-arz8r204	29	9	fuse	fuse	VBP
cord-272051-arz8r204	29	10	their	-PRON-	PRP$
cord-272051-arz8r204	29	11	envelope	envelope	NN
cord-272051-arz8r204	29	12	either	either	CC
cord-272051-arz8r204	29	13	at	at	IN
cord-272051-arz8r204	29	14	the	the	DT
cord-272051-arz8r204	29	15	cell	cell	NN
cord-272051-arz8r204	29	16	surface	surface	NN
cord-272051-arz8r204	29	17	in	in	IN
cord-272051-arz8r204	29	18	a	a	DT
cord-272051-arz8r204	29	19	pH	ph	JJ
cord-272051-arz8r204	29	20	-	-	JJ
cord-272051-arz8r204	29	21	independent	independent	JJ
cord-272051-arz8r204	29	22	way	way	NN
cord-272051-arz8r204	29	23	,	,	,
cord-272051-arz8r204	29	24	or	or	CC
cord-272051-arz8r204	29	25	upon	upon	IN
cord-272051-arz8r204	29	26	internalization	internalization	NN
cord-272051-arz8r204	29	27	in	in	IN
cord-272051-arz8r204	29	28	intracellular	intracellular	JJ
cord-272051-arz8r204	29	29	vesicles	vesicle	NNS
cord-272051-arz8r204	29	30	through	through	IN
cord-272051-arz8r204	29	31	a	a	DT
cord-272051-arz8r204	29	32	pH	ph	JJ
cord-272051-arz8r204	29	33	-	-	HYPH
cord-272051-arz8r204	29	34	dependent	dependent	JJ
cord-272051-arz8r204	29	35	mechanism	mechanism	NN
cord-272051-arz8r204	29	36	(	(	-LRB-
cord-272051-arz8r204	29	37	Steven	Steven	NNP
cord-272051-arz8r204	29	38	and	and	CC
cord-272051-arz8r204	29	39	Spear	Spear	NNP
cord-272051-arz8r204	29	40	,	,	,
cord-272051-arz8r204	29	41	2006	2006	CD
cord-272051-arz8r204	29	42	)	)	-RRB-
cord-272051-arz8r204	29	43	.	.	.
cord-272051-arz8r204	30	1	In	in	IN
cord-272051-arz8r204	30	2	this	this	DT
cord-272051-arz8r204	30	3	latter	latter	JJ
cord-272051-arz8r204	30	4	case	case	NN
cord-272051-arz8r204	30	5	,	,	,
cord-272051-arz8r204	30	6	low	low	JJ
cord-272051-arz8r204	30	7	pH	pH	NNP
cord-272051-arz8r204	30	8	is	be	VBZ
cord-272051-arz8r204	30	9	required	require	VBN
cord-272051-arz8r204	30	10	to	to	TO
cord-272051-arz8r204	30	11	induce	induce	VB
cord-272051-arz8r204	30	12	the	the	DT
cord-272051-arz8r204	30	13	fusion	fusion	NN
cord-272051-arz8r204	30	14	between	between	IN
cord-272051-arz8r204	30	15	viral	viral	JJ
cord-272051-arz8r204	30	16	envelope	envelope	NN
cord-272051-arz8r204	30	17	and	and	CC
cord-272051-arz8r204	30	18	endosomal	endosomal	NNP
cord-272051-arz8r204	30	19	membranes	membrane	NNS
cord-272051-arz8r204	30	20	,	,	,
cord-272051-arz8r204	30	21	a	a	DT
cord-272051-arz8r204	30	22	phenomenon	phenomenon	NN
cord-272051-arz8r204	30	23	leading	lead	VBG
cord-272051-arz8r204	30	24	to	to	IN
cord-272051-arz8r204	30	25	the	the	DT
cord-272051-arz8r204	30	26	release	release	NN
cord-272051-arz8r204	30	27	of	of	IN
cord-272051-arz8r204	30	28	virion	virion	NN
cord-272051-arz8r204	30	29	contents	content	NNS
cord-272051-arz8r204	30	30	into	into	IN
cord-272051-arz8r204	30	31	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	30	32	.	.	.
cord-272051-arz8r204	31	1	Although	although	IN
cord-272051-arz8r204	31	2	the	the	DT
cord-272051-arz8r204	31	3	viral	viral	JJ
cord-272051-arz8r204	31	4	fusion	fusion	NN
cord-272051-arz8r204	31	5	process	process	NN
cord-272051-arz8r204	31	6	is	be	VBZ
cord-272051-arz8r204	31	7	guided	guide	VBN
cord-272051-arz8r204	31	8	by	by	IN
cord-272051-arz8r204	31	9	the	the	DT
cord-272051-arz8r204	31	10	presence	presence	NN
cord-272051-arz8r204	31	11	of	of	IN
cord-272051-arz8r204	31	12	viral	viral	JJ
cord-272051-arz8r204	31	13	envelope	envelope	NN
cord-272051-arz8r204	31	14	proteins	protein	NNS
cord-272051-arz8r204	31	15	,	,	,
cord-272051-arz8r204	31	16	the	the	DT
cord-272051-arz8r204	31	17	contribution	contribution	NN
cord-272051-arz8r204	31	18	of	of	IN
cord-272051-arz8r204	31	19	cell	cell	NN
cord-272051-arz8r204	31	20	proteins	protein	NNS
cord-272051-arz8r204	31	21	is	be	VBZ
cord-272051-arz8r204	31	22	critical	critical	JJ
cord-272051-arz8r204	31	23	.	.	.
cord-272051-arz8r204	32	1	Using	use	VBG
cord-272051-arz8r204	32	2	RNA	RNA	NNP
cord-272051-arz8r204	32	3	interference	interference	NN
cord-272051-arz8r204	32	4	as	as	IN
cord-272051-arz8r204	32	5	a	a	DT
cord-272051-arz8r204	32	6	tool	tool	NN
cord-272051-arz8r204	32	7	for	for	IN
cord-272051-arz8r204	32	8	gene	gene	NN
cord-272051-arz8r204	32	9	expression	expression	NN
cord-272051-arz8r204	32	10	inhibition	inhibition	NN
cord-272051-arz8r204	32	11	,	,	,
cord-272051-arz8r204	32	12	it	-PRON-	PRP
cord-272051-arz8r204	32	13	was	be	VBD
cord-272051-arz8r204	32	14	demonstrated	demonstrate	VBN
cord-272051-arz8r204	32	15	that	that	IN
cord-272051-arz8r204	32	16	several	several	JJ
cord-272051-arz8r204	32	17	cell	cell	NN
cord-272051-arz8r204	32	18	proteins	protein	NNS
cord-272051-arz8r204	32	19	are	be	VBP
cord-272051-arz8r204	32	20	involved	involve	VBN
cord-272051-arz8r204	32	21	in	in	IN
cord-272051-arz8r204	32	22	the	the	DT
cord-272051-arz8r204	32	23	mechanism	mechanism	NN
cord-272051-arz8r204	32	24	of	of	IN
cord-272051-arz8r204	32	25	entry	entry	NN
cord-272051-arz8r204	32	26	of	of	IN
cord-272051-arz8r204	32	27	many	many	JJ
cord-272051-arz8r204	32	28	viruses	virus	NNS
cord-272051-arz8r204	32	29	including	include	VBG
cord-272051-arz8r204	32	30	HIV-1	HIV-1	NNP
cord-272051-arz8r204	32	31	Nguyen	Nguyen	NNP
cord-272051-arz8r204	32	32	et	et	NNP
cord-272051-arz8r204	32	33	al	al	NNP
cord-272051-arz8r204	32	34	.	.	NNP
cord-272051-arz8r204	32	35	,	,	,
cord-272051-arz8r204	32	36	2006	2006	CD
cord-272051-arz8r204	32	37	)	)	-RRB-
cord-272051-arz8r204	32	38	,	,	,
cord-272051-arz8r204	32	39	influenza	influenza	NN
cord-272051-arz8r204	32	40	(	(	-LRB-
cord-272051-arz8r204	32	41	Hao	Hao	NNP
cord-272051-arz8r204	32	42	et	et	NNP
cord-272051-arz8r204	32	43	al	al	NNP
cord-272051-arz8r204	32	44	.	.	NNP
cord-272051-arz8r204	32	45	,	,	,
cord-272051-arz8r204	32	46	2008	2008	CD
cord-272051-arz8r204	32	47	)	)	-RRB-
cord-272051-arz8r204	32	48	,	,	,
cord-272051-arz8r204	32	49	west	west	NNP
cord-272051-arz8r204	32	50	Nile	Nile	NNP
cord-272051-arz8r204	32	51	(	(	-LRB-
cord-272051-arz8r204	32	52	Krishnan	Krishnan	NNP
cord-272051-arz8r204	32	53	et	et	NNP
cord-272051-arz8r204	32	54	al	al	NNP
cord-272051-arz8r204	32	55	.	.	NNP
cord-272051-arz8r204	32	56	,	,	,
cord-272051-arz8r204	32	57	2008	2008	CD
cord-272051-arz8r204	32	58	)	)	-RRB-
cord-272051-arz8r204	32	59	,	,	,
cord-272051-arz8r204	32	60	Borna	Borna	NNP
cord-272051-arz8r204	32	61	disease	disease	NN
cord-272051-arz8r204	32	62	(	(	-LRB-
cord-272051-arz8r204	32	63	Clemente	Clemente	NNP
cord-272051-arz8r204	32	64	et	et	NNP
cord-272051-arz8r204	32	65	al	al	NNP
cord-272051-arz8r204	32	66	.	.	NNP
cord-272051-arz8r204	32	67	,	,	,
cord-272051-arz8r204	32	68	2010	2010	CD
cord-272051-arz8r204	32	69	)	)	-RRB-
cord-272051-arz8r204	32	70	,	,	,
cord-272051-arz8r204	32	71	human	human	JJ
cord-272051-arz8r204	32	72	hepatitis	hepatitis	NN
cord-272051-arz8r204	32	73	C	C	NNP
cord-272051-arz8r204	32	74	(	(	-LRB-
cord-272051-arz8r204	32	75	Ng	Ng	NNP
cord-272051-arz8r204	32	76	et	et	FW
cord-272051-arz8r204	32	77	al	al	NNP
cord-272051-arz8r204	32	78	.	.	NNP
cord-272051-arz8r204	32	79	,	,	,
cord-272051-arz8r204	32	80	2007	2007	CD
cord-272051-arz8r204	32	81	)	)	-RRB-
cord-272051-arz8r204	32	82	,	,	,
cord-272051-arz8r204	32	83	and	and	CC
cord-272051-arz8r204	32	84	vesicular	vesicular	JJ
cord-272051-arz8r204	32	85	stomatitis	stomatitis	NN
cord-272051-arz8r204	32	86	(	(	-LRB-
cord-272051-arz8r204	32	87	VSV	VSV	NNP
cord-272051-arz8r204	32	88	)	)	-RRB-
cord-272051-arz8r204	33	1	(	(	-LRB-
cord-272051-arz8r204	33	2	Pelkmans	Pelkmans	NNP
cord-272051-arz8r204	33	3	et	et	NNP
cord-272051-arz8r204	33	4	al	al	NNP
cord-272051-arz8r204	33	5	.	.	NNP
cord-272051-arz8r204	33	6	,	,	,
cord-272051-arz8r204	33	7	2005	2005	CD
cord-272051-arz8r204	33	8	)	)	-RRB-
cord-272051-arz8r204	33	9	viruses	virus	NNS
cord-272051-arz8r204	33	10	.	.	.
cord-272051-arz8r204	34	1	Ideally	ideally	RB
cord-272051-arz8r204	34	2	,	,	,
cord-272051-arz8r204	34	3	these	these	DT
cord-272051-arz8r204	34	4	cell	cell	NN
cord-272051-arz8r204	34	5	products	product	NNS
cord-272051-arz8r204	34	6	might	may	MD
cord-272051-arz8r204	34	7	represent	represent	VB
cord-272051-arz8r204	34	8	potential	potential	JJ
cord-272051-arz8r204	34	9	antiviral	antiviral	JJ
cord-272051-arz8r204	34	10	therapeutic	therapeutic	JJ
cord-272051-arz8r204	34	11	targets	target	NNS
cord-272051-arz8r204	34	12	.	.	.
cord-272051-arz8r204	35	1	Here	here	RB
cord-272051-arz8r204	35	2	,	,	,
cord-272051-arz8r204	35	3	the	the	DT
cord-272051-arz8r204	35	4	PI	pi	NN
cord-272051-arz8r204	35	5	-	-	HYPH
cord-272051-arz8r204	35	6	induced	induce	VBN
cord-272051-arz8r204	35	7	inhibition	inhibition	NN
cord-272051-arz8r204	35	8	of	of	IN
cord-272051-arz8r204	35	9	replication	replication	NN
cord-272051-arz8r204	35	10	of	of	IN
cord-272051-arz8r204	35	11	both	both	CC
cord-272051-arz8r204	35	12	VSV	VSV	NNP
cord-272051-arz8r204	35	13	and	and	CC
cord-272051-arz8r204	35	14	influenza	influenza	NN
cord-272051-arz8r204	35	15	virus	virus	NN
cord-272051-arz8r204	35	16	is	be	VBZ
cord-272051-arz8r204	35	17	described	describe	VBN
cord-272051-arz8r204	35	18	for	for	IN
cord-272051-arz8r204	35	19	the	the	DT
cord-272051-arz8r204	35	20	first	first	JJ
cord-272051-arz8r204	35	21	time	time	NN
cord-272051-arz8r204	35	22	.	.	.
cord-272051-arz8r204	36	1	This	this	DT
cord-272051-arz8r204	36	2	was	be	VBD
cord-272051-arz8r204	36	3	most	most	RBS
cord-272051-arz8r204	36	4	likely	likely	RB
cord-272051-arz8r204	36	5	a	a	DT
cord-272051-arz8r204	36	6	consequence	consequence	NN
cord-272051-arz8r204	36	7	of	of	IN
cord-272051-arz8r204	36	8	a	a	DT
cord-272051-arz8r204	36	9	PI	pi	NN
cord-272051-arz8r204	36	10	-	-	HYPH
cord-272051-arz8r204	36	11	dependent	dependent	JJ
cord-272051-arz8r204	36	12	block	block	NN
cord-272051-arz8r204	36	13	of	of	IN
cord-272051-arz8r204	36	14	the	the	DT
cord-272051-arz8r204	36	15	viral	viral	JJ
cord-272051-arz8r204	36	16	envelope	envelope	NN
cord-272051-arz8r204	36	17	fusion	fusion	NN
cord-272051-arz8r204	36	18	at	at	IN
cord-272051-arz8r204	36	19	the	the	DT
cord-272051-arz8r204	36	20	endosomes	endosome	NNS
cord-272051-arz8r204	36	21	.	.	.
cord-272051-arz8r204	37	1	Considering	consider	VBG
cord-272051-arz8r204	37	2	that	that	IN
cord-272051-arz8r204	37	3	PIs	pi	NNS
cord-272051-arz8r204	37	4	are	be	VBP
cord-272051-arz8r204	37	5	well	well	RB
cord-272051-arz8r204	37	6	tolerated	tolerate	VBN
cord-272051-arz8r204	37	7	drugs	drug	NNS
cord-272051-arz8r204	37	8	in	in	IN
cord-272051-arz8r204	37	9	vivo	vivo	NN
cord-272051-arz8r204	37	10	,	,	,
cord-272051-arz8r204	37	11	and	and	CC
cord-272051-arz8r204	37	12	that	that	IN
cord-272051-arz8r204	37	13	many	many	JJ
cord-272051-arz8r204	37	14	relevant	relevant	JJ
cord-272051-arz8r204	37	15	human	human	JJ
cord-272051-arz8r204	37	16	pathogens	pathogen	NNS
cord-272051-arz8r204	37	17	belong	belong	VBP
cord-272051-arz8r204	37	18	to	to	IN
cord-272051-arz8r204	37	19	the	the	DT
cord-272051-arz8r204	37	20	family	family	NN
cord-272051-arz8r204	37	21	of	of	IN
cord-272051-arz8r204	37	22	RNA	RNA	NNP
cord-272051-arz8r204	37	23	viruses	virus	NNS
cord-272051-arz8r204	37	24	infecting	infect	VBG
cord-272051-arz8r204	37	25	cells	cell	NNS
cord-272051-arz8r204	37	26	through	through	IN
cord-272051-arz8r204	37	27	an	an	DT
cord-272051-arz8r204	37	28	endocytic	endocytic	JJ
cord-272051-arz8r204	37	29	pathway	pathway	NN
cord-272051-arz8r204	37	30	,	,	,
cord-272051-arz8r204	37	31	this	this	DT
cord-272051-arz8r204	37	32	finding	finding	NN
cord-272051-arz8r204	37	33	would	would	MD
cord-272051-arz8r204	37	34	open	open	VB
cord-272051-arz8r204	37	35	the	the	DT
cord-272051-arz8r204	37	36	way	way	NN
cord-272051-arz8r204	37	37	towards	towards	IN
cord-272051-arz8r204	37	38	a	a	DT
cord-272051-arz8r204	37	39	broader	broader	RBR
cord-272051-arz8r204	37	40	therapeutic	therapeutic	JJ
cord-272051-arz8r204	37	41	use	use	NN
cord-272051-arz8r204	37	42	of	of	IN
cord-272051-arz8r204	37	43	PIs	pi	NNS
cord-272051-arz8r204	37	44	.	.	.
cord-272051-arz8r204	38	1	HIV	HIV	NNP
cord-272051-arz8r204	38	2	virions	virion	NNS
cord-272051-arz8r204	38	3	emerging	emerge	VBG
cord-272051-arz8r204	38	4	from	from	IN
cord-272051-arz8r204	38	5	cells	cell	NNS
cord-272051-arz8r204	38	6	treated	treat	VBN
cord-272051-arz8r204	38	7	with	with	IN
cord-272051-arz8r204	38	8	PIs	pi	NNS
cord-272051-arz8r204	38	9	remain	remain	VBP
cord-272051-arz8r204	38	10	immature	immature	JJ
cord-272051-arz8r204	38	11	viral	viral	JJ
cord-272051-arz8r204	38	12	particles	particle	NNS
cord-272051-arz8r204	38	13	as	as	IN
cord-272051-arz8r204	38	14	a	a	DT
cord-272051-arz8r204	38	15	consequence	consequence	NN
cord-272051-arz8r204	38	16	of	of	IN
cord-272051-arz8r204	38	17	the	the	DT
cord-272051-arz8r204	38	18	block	block	NN
cord-272051-arz8r204	38	19	of	of	IN
cord-272051-arz8r204	38	20	Gag	Gag	NNP
cord-272051-arz8r204	38	21	polyprotein	polyprotein	NN
cord-272051-arz8r204	38	22	cleavage	cleavage	NN
cord-272051-arz8r204	38	23	.	.	.
cord-272051-arz8r204	39	1	Hence	hence	RB
cord-272051-arz8r204	39	2	,	,	,
cord-272051-arz8r204	39	3	PIs	pi	NNS
cord-272051-arz8r204	39	4	do	do	VBP
cord-272051-arz8r204	39	5	not	not	RB
cord-272051-arz8r204	39	6	affect	affect	VB
cord-272051-arz8r204	39	7	the	the	DT
cord-272051-arz8r204	39	8	amounts	amount	NNS
cord-272051-arz8r204	39	9	of	of	IN
cord-272051-arz8r204	39	10	HIV	HIV	NNP
cord-272051-arz8r204	39	11	release	release	NN
cord-272051-arz8r204	39	12	from	from	IN
cord-272051-arz8r204	39	13	infected	infected	JJ
cord-272051-arz8r204	39	14	cells	cell	NNS
cord-272051-arz8r204	39	15	,	,	,
cord-272051-arz8r204	39	16	but	but	CC
cord-272051-arz8r204	39	17	dramatically	dramatically	RB
cord-272051-arz8r204	39	18	decrease	decrease	VB
cord-272051-arz8r204	39	19	their	-PRON-	PRP$
cord-272051-arz8r204	39	20	infectivity	infectivity	NN
cord-272051-arz8r204	39	21	.	.	.
cord-272051-arz8r204	40	1	Surprisingly	surprisingly	RB
cord-272051-arz8r204	40	2	enough	enough	RB
cord-272051-arz8r204	40	3	,	,	,
cord-272051-arz8r204	40	4	however	however	RB
cord-272051-arz8r204	40	5	,	,	,
cord-272051-arz8r204	40	6	the	the	DT
cord-272051-arz8r204	40	7	HIV-1	HIV-1	NNP
cord-272051-arz8r204	40	8	release	release	NN
cord-272051-arz8r204	40	9	from	from	IN
cord-272051-arz8r204	40	10	cells	cell	NNS
cord-272051-arz8r204	40	11	infected	infect	VBN
cord-272051-arz8r204	40	12	with	with	IN
cord-272051-arz8r204	40	13	HIV-1	HIV-1	NNP
cord-272051-arz8r204	40	14	pseudotyped	pseudotyped	NNS
cord-272051-arz8r204	40	15	with	with	IN
cord-272051-arz8r204	40	16	the	the	DT
cord-272051-arz8r204	40	17	envelope	envelope	NN
cord-272051-arz8r204	40	18	protein	protein	NN
cord-272051-arz8r204	40	19	from	from	IN
cord-272051-arz8r204	40	20	VSV	VSV	NNP
cord-272051-arz8r204	40	21	(	(	-LRB-
cord-272051-arz8r204	40	22	VSV	VSV	NNP
cord-272051-arz8r204	40	23	-	-	HYPH
cord-272051-arz8r204	40	24	G	G	NNP
cord-272051-arz8r204	40	25	)	)	-RRB-
cord-272051-arz8r204	40	26	has	have	VBZ
cord-272051-arz8r204	40	27	been	be	VBN
cord-272051-arz8r204	40	28	found	find	VBN
cord-272051-arz8r204	40	29	inhibited	inhibit	VBN
cord-272051-arz8r204	40	30	by	by	IN
cord-272051-arz8r204	40	31	PIs	pi	NNS
cord-272051-arz8r204	40	32	in	in	IN
cord-272051-arz8r204	40	33	single	single	JJ
cord-272051-arz8r204	40	34	cycle	cycle	NN
cord-272051-arz8r204	40	35	replication	replication	NN
cord-272051-arz8r204	40	36	assays	assay	NNS
cord-272051-arz8r204	40	37	.	.	.
cord-272051-arz8r204	41	1	In	in	IN
cord-272051-arz8r204	41	2	fact	fact	NN
cord-272051-arz8r204	41	3	,	,	,
cord-272051-arz8r204	41	4	when	when	WRB
cord-272051-arz8r204	41	5	CEM	CEM	NNP
cord-272051-arz8r204	41	6	GFP	GFP	NNP
cord-272051-arz8r204	41	7	cells	cell	NNS
cord-272051-arz8r204	41	8	,	,	,
cord-272051-arz8r204	41	9	i.e.	i.e.	FW
cord-272051-arz8r204	41	10	,	,	,
cord-272051-arz8r204	41	11	a	a	DT
cord-272051-arz8r204	41	12	human	human	JJ
cord-272051-arz8r204	41	13	T	T	NNP
cord-272051-arz8r204	41	14	CD4	CD4	NNP
cord-272051-arz8r204	41	15	+	+	CC
cord-272051-arz8r204	41	16	lymphoblastoid	lymphoblastoid	NN
cord-272051-arz8r204	41	17	cell	cell	NN
cord-272051-arz8r204	41	18	line	line	NN
cord-272051-arz8r204	41	19	expressing	express	VBG
cord-272051-arz8r204	41	20	GFP	GFP	NNP
cord-272051-arz8r204	41	21	under	under	IN
cord-272051-arz8r204	41	22	the	the	DT
cord-272051-arz8r204	41	23	control	control	NN
cord-272051-arz8r204	41	24	of	of	IN
cord-272051-arz8r204	41	25	HIV-1	HIV-1	NNP
cord-272051-arz8r204	41	26	LTRs	LTRs	NNPS
cord-272051-arz8r204	41	27	(	(	-LRB-
cord-272051-arz8r204	41	28	Gervaix	Gervaix	NNP
cord-272051-arz8r204	41	29	et	et	FW
cord-272051-arz8r204	41	30	al	al	NNP
cord-272051-arz8r204	41	31	.	.	NNP
cord-272051-arz8r204	41	32	,	,	,
cord-272051-arz8r204	41	33	1997	1997	CD
cord-272051-arz8r204	41	34	)	)	-RRB-
cord-272051-arz8r204	41	35	,	,	,
cord-272051-arz8r204	41	36	were	be	VBD
cord-272051-arz8r204	41	37	infected	infect	VBN
cord-272051-arz8r204	41	38	with	with	IN
cord-272051-arz8r204	41	39	100	100	CD
cord-272051-arz8r204	41	40	ng	ng	NN
cord-272051-arz8r204	42	1	HIV-1	HIV-1	NNP
cord-272051-arz8r204	42	2	CAp24	cap24	IN
cord-272051-arz8r204	42	3	equivalent/10	equivalent/10	NNP
cord-272051-arz8r204	42	4	5	5	CD
cord-272051-arz8r204	42	5	cells	cell	NNS
cord-272051-arz8r204	42	6	of	of	IN
cord-272051-arz8r204	42	7	(	(	-LRB-
cord-272051-arz8r204	42	8	VSV	VSV	NNP
cord-272051-arz8r204	42	9	-	-	HYPH
cord-272051-arz8r204	42	10	G	G	NNP
cord-272051-arz8r204	42	11	)	)	-RRB-
cord-272051-arz8r204	43	1	Δenv	Δenv	NNP
cord-272051-arz8r204	43	2	HIV-1	HIV-1	NNP
cord-272051-arz8r204	43	3	,	,	,
cord-272051-arz8r204	43	4	decreased	decrease	VBD
cord-272051-arz8r204	43	5	percentages	percentage	NNS
cord-272051-arz8r204	43	6	of	of	IN
cord-272051-arz8r204	43	7	HIV-1	HIV-1	NNP
cord-272051-arz8r204	43	8	expressing	express	VBG
cord-272051-arz8r204	43	9	cells	cell	NNS
cord-272051-arz8r204	43	10	were	be	VBD
cord-272051-arz8r204	43	11	observed	observe	VBN
cord-272051-arz8r204	43	12	in	in	IN
cord-272051-arz8r204	43	13	ritonavir	ritonavir	NNS
cord-272051-arz8r204	43	14	-	-	HYPH
cord-272051-arz8r204	43	15	treated	treat	VBN
cord-272051-arz8r204	43	16	cells	cell	NNS
cord-272051-arz8r204	43	17	as	as	IN
cord-272051-arz8r204	43	18	compared	compare	VBN
cord-272051-arz8r204	43	19	to	to	IN
cord-272051-arz8r204	43	20	control	control	NN
cord-272051-arz8r204	43	21	conditions	condition	NNS
cord-272051-arz8r204	43	22	(	(	-LRB-
cord-272051-arz8r204	43	23	Fig	Fig	NNP
cord-272051-arz8r204	43	24	.	.	.
cord-272051-arz8r204	43	25	1A	1a	NN
cord-272051-arz8r204	43	26	)	)	-RRB-
cord-272051-arz8r204	43	27	.	.	.
cord-272051-arz8r204	44	1	The	the	DT
cord-272051-arz8r204	44	2	outcome	outcome	NN
cord-272051-arz8r204	44	3	did	do	VBD
cord-272051-arz8r204	44	4	not	not	RB
cord-272051-arz8r204	44	5	change	change	VB
cord-272051-arz8r204	44	6	by	by	IN
cord-272051-arz8r204	44	7	challenging	challenge	VBG
cord-272051-arz8r204	44	8	the	the	DT
cord-272051-arz8r204	44	9	cells	cell	NNS
cord-272051-arz8r204	44	10	with	with	IN
cord-272051-arz8r204	44	11	doses	dose	NNS
cord-272051-arz8r204	44	12	up	up	IN
cord-272051-arz8r204	44	13	to	to	TO
cord-272051-arz8r204	44	14	300	300	CD
cord-272051-arz8r204	44	15	ng	ng	NNP
cord-272051-arz8r204	44	16	HIV-1	HIV-1	NNP
cord-272051-arz8r204	44	17	CAp24	cap24	IN
cord-272051-arz8r204	44	18	equivalent/10	equivalent/10	NNP
cord-272051-arz8r204	44	19	5	5	CD
cord-272051-arz8r204	44	20	cells	cell	NNS
cord-272051-arz8r204	44	21	(	(	-LRB-
cord-272051-arz8r204	44	22	not	not	RB
cord-272051-arz8r204	44	23	shown	show	VBN
cord-272051-arz8r204	44	24	)	)	-RRB-
cord-272051-arz8r204	44	25	.	.	.
cord-272051-arz8r204	45	1	Conversely	conversely	RB
cord-272051-arz8r204	45	2	,	,	,
cord-272051-arz8r204	45	3	and	and	CC
cord-272051-arz8r204	45	4	as	as	IN
cord-272051-arz8r204	45	5	expected	expect	VBN
cord-272051-arz8r204	45	6	,	,	,
cord-272051-arz8r204	45	7	the	the	DT
cord-272051-arz8r204	45	8	PI	pi	NN
cord-272051-arz8r204	45	9	-	-	HYPH
cord-272051-arz8r204	45	10	treatment	treatment	NN
cord-272051-arz8r204	45	11	had	have	VBD
cord-272051-arz8r204	45	12	no	no	DT
cord-272051-arz8r204	45	13	apparent	apparent	JJ
cord-272051-arz8r204	45	14	effects	effect	NNS
cord-272051-arz8r204	45	15	on	on	IN
cord-272051-arz8r204	45	16	single	single	JJ
cord-272051-arz8r204	45	17	cycle	cycle	NN
cord-272051-arz8r204	45	18	replication	replication	NN
cord-272051-arz8r204	45	19	of	of	IN
cord-272051-arz8r204	45	20	non	non	JJ
cord-272051-arz8r204	45	21	-	-	JJ
cord-272051-arz8r204	45	22	pseudotyped	pseudotyped	JJ
cord-272051-arz8r204	45	23	HIV-1	HIV-1	NNP
cord-272051-arz8r204	45	24	,	,	,
cord-272051-arz8r204	45	25	as	as	IN
cord-272051-arz8r204	45	26	tested	test	VBN
cord-272051-arz8r204	45	27	in	in	IN
cord-272051-arz8r204	45	28	PI	PI	NNP
cord-272051-arz8r204	45	29	-	-	HYPH
cord-272051-arz8r204	45	30	treated	treat	VBN
cord-272051-arz8r204	45	31	cultures	culture	NNS
cord-272051-arz8r204	45	32	of	of	IN
cord-272051-arz8r204	45	33	CEM	CEM	NNP
cord-272051-arz8r204	45	34	GFP	GFP	NNP
cord-272051-arz8r204	45	35	cells	cell	NNS
cord-272051-arz8r204	45	36	infected	infect	VBN
cord-272051-arz8r204	45	37	with	with	IN
cord-272051-arz8r204	45	38	wt	wt	NN
cord-272051-arz8r204	45	39	HIV-1	HIV-1	NNP
cord-272051-arz8r204	45	40	(	(	-LRB-
cord-272051-arz8r204	45	41	Fig	Fig	NNP
cord-272051-arz8r204	45	42	.	.	.
cord-272051-arz8r204	45	43	1B	1b	CD
cord-272051-arz8r204	45	44	)	)	-RRB-
cord-272051-arz8r204	45	45	.	.	.
cord-272051-arz8r204	46	1	In	in	IN
cord-272051-arz8r204	46	2	these	these	DT
cord-272051-arz8r204	46	3	experiments	experiment	NNS
cord-272051-arz8r204	46	4	,	,	,
cord-272051-arz8r204	46	5	the	the	DT
cord-272051-arz8r204	46	6	presence	presence	NN
cord-272051-arz8r204	46	7	of	of	IN
cord-272051-arz8r204	46	8	T-20	T-20	NNP
cord-272051-arz8r204	46	9	(	(	-LRB-
cord-272051-arz8r204	46	10	i.e.	i.e.	FW
cord-272051-arz8r204	46	11	,	,	,
cord-272051-arz8r204	46	12	a	a	DT
cord-272051-arz8r204	46	13	potent	potent	JJ
cord-272051-arz8r204	46	14	inhibitor	inhibitor	NN
cord-272051-arz8r204	46	15	of	of	IN
cord-272051-arz8r204	46	16	the	the	DT
cord-272051-arz8r204	46	17	HIV-1	HIV-1	NNP
cord-272051-arz8r204	46	18	Env	Env	NNP
cord-272051-arz8r204	46	19	-	-	HYPH
cord-272051-arz8r204	46	20	mediated	mediate	VBN
cord-272051-arz8r204	46	21	fusion	fusion	NN
cord-272051-arz8r204	46	22	)	)	-RRB-
cord-272051-arz8r204	46	23	(	(	-LRB-
cord-272051-arz8r204	46	24	Kilby	Kilby	NNP
cord-272051-arz8r204	46	25	et	et	NNP
cord-272051-arz8r204	46	26	al	al	NNP
cord-272051-arz8r204	46	27	.	.	NNP
cord-272051-arz8r204	46	28	,	,	,
cord-272051-arz8r204	46	29	1998	1998	CD
cord-272051-arz8r204	46	30	)	)	-RRB-
cord-272051-arz8r204	46	31	added	add	VBD
cord-272051-arz8r204	46	32	16	16	CD
cord-272051-arz8r204	46	33	h	h	NN
cord-272051-arz8r204	46	34	after	after	IN
cord-272051-arz8r204	46	35	challenge	challenge	NN
cord-272051-arz8r204	46	36	ensured	ensure	VBD
cord-272051-arz8r204	46	37	that	that	IN
cord-272051-arz8r204	46	38	the	the	DT
cord-272051-arz8r204	46	39	wt	wt	NN
cord-272051-arz8r204	46	40	HIV-1	HIV-1	NNP
cord-272051-arz8r204	46	41	replication	replication	NN
cord-272051-arz8r204	46	42	was	be	VBD
cord-272051-arz8r204	46	43	limited	limit	VBN
cord-272051-arz8r204	46	44	to	to	IN
cord-272051-arz8r204	46	45	a	a	DT
cord-272051-arz8r204	46	46	single	single	JJ
cord-272051-arz8r204	46	47	cycle	cycle	NN
cord-272051-arz8r204	46	48	.	.	.
cord-272051-arz8r204	47	1	As	as	IN
cord-272051-arz8r204	47	2	anticipated	anticipate	VBN
cord-272051-arz8r204	47	3	,	,	,
cord-272051-arz8r204	47	4	ritonavir	ritonavir	NNP
cord-272051-arz8r204	47	5	blocked	block	VBD
cord-272051-arz8r204	47	6	the	the	DT
cord-272051-arz8r204	47	7	spread	spread	NN
cord-272051-arz8r204	47	8	of	of	IN
cord-272051-arz8r204	47	9	wt	wt	NN
cord-272051-arz8r204	47	10	HIV-1	HIV-1	NNP
cord-272051-arz8r204	47	11	in	in	IN
cord-272051-arz8r204	47	12	multiple	multiple	JJ
cord-272051-arz8r204	47	13	-	-	HYPH
cord-272051-arz8r204	47	14	cycle	cycle	NN
cord-272051-arz8r204	47	15	replication	replication	NN
cord-272051-arz8r204	47	16	assay	assay	NN
cord-272051-arz8r204	47	17	(	(	-LRB-
cord-272051-arz8r204	47	18	Fig	Fig	NNP
cord-272051-arz8r204	47	19	.	.	.
cord-272051-arz8r204	47	20	1B	1b	CD
cord-272051-arz8r204	47	21	)	)	-RRB-
cord-272051-arz8r204	47	22	.	.	.
cord-272051-arz8r204	48	1	To	to	TO
cord-272051-arz8r204	48	2	exclude	exclude	VB
cord-272051-arz8r204	48	3	that	that	IN
cord-272051-arz8r204	48	4	the	the	DT
cord-272051-arz8r204	48	5	observed	observed	JJ
cord-272051-arz8r204	48	6	effect	effect	NN
cord-272051-arz8r204	48	7	was	be	VBD
cord-272051-arz8r204	48	8	a	a	DT
cord-272051-arz8r204	48	9	consequence	consequence	NN
cord-272051-arz8r204	48	10	of	of	IN
cord-272051-arz8r204	48	11	the	the	DT
cord-272051-arz8r204	48	12	inhibition	inhibition	NN
cord-272051-arz8r204	48	13	of	of	IN
cord-272051-arz8r204	48	14	some	some	DT
cord-272051-arz8r204	48	15	yet	yet	RB
cord-272051-arz8r204	48	16	unidentified	unidentified	JJ
cord-272051-arz8r204	48	17	function	function	NN
cord-272051-arz8r204	48	18	of	of	IN
cord-272051-arz8r204	48	19	the	the	DT
cord-272051-arz8r204	48	20	HIV-1	HIV-1	NNP
cord-272051-arz8r204	48	21	protease	protease	NN
cord-272051-arz8r204	48	22	at	at	IN
cord-272051-arz8r204	48	23	an	an	DT
cord-272051-arz8r204	48	24	early	early	JJ
cord-272051-arz8r204	48	25	step	step	NN
cord-272051-arz8r204	48	26	of	of	IN
cord-272051-arz8r204	48	27	the	the	DT
cord-272051-arz8r204	48	28	virus	virus	NN
cord-272051-arz8r204	48	29	life	life	NN
cord-272051-arz8r204	48	30	cycle	cycle	NN
cord-272051-arz8r204	48	31	,	,	,
cord-272051-arz8r204	48	32	the	the	DT
cord-272051-arz8r204	48	33	assay	assay	NN
cord-272051-arz8r204	48	34	was	be	VBD
cord-272051-arz8r204	48	35	reproduced	reproduce	VBN
cord-272051-arz8r204	48	36	using	use	VBG
cord-272051-arz8r204	48	37	a	a	DT
cord-272051-arz8r204	48	38	VSV	VSV	NNP
cord-272051-arz8r204	48	39	-	-	HYPH
cord-272051-arz8r204	48	40	G	g	NN
cord-272051-arz8r204	48	41	pseudotyped	pseudotyped	NNS
cord-272051-arz8r204	48	42	,	,	,
cord-272051-arz8r204	48	43	PI	pi	NN
cord-272051-arz8r204	48	44	-	-	HYPH
cord-272051-arz8r204	48	45	resistant	resistant	JJ
cord-272051-arz8r204	48	46	HIV-1	HIV-1	NNP
cord-272051-arz8r204	48	47	strain	strain	NN
cord-272051-arz8r204	48	48	(	(	-LRB-
cord-272051-arz8r204	48	49	here	here	RB
cord-272051-arz8r204	48	50	referred	refer	VBN
cord-272051-arz8r204	48	51	to	to	IN
cord-272051-arz8r204	48	52	as	as	IN
cord-272051-arz8r204	48	53	PM4	PM4	NNP
cord-272051-arz8r204	48	54	)	)	-RRB-
cord-272051-arz8r204	48	55	.	.	.
cord-272051-arz8r204	49	1	This	this	DT
cord-272051-arz8r204	49	2	viral	viral	JJ
cord-272051-arz8r204	49	3	mutant	mutant	NN
cord-272051-arz8r204	49	4	expresses	express	VBZ
cord-272051-arz8r204	49	5	a	a	DT
cord-272051-arz8r204	49	6	PI	pi	NN
cord-272051-arz8r204	49	7	-	-	HYPH
cord-272051-arz8r204	49	8	resistant	resistant	JJ
cord-272051-arz8r204	49	9	viral	viral	JJ
cord-272051-arz8r204	49	10	protease	protease	NN
cord-272051-arz8r204	49	11	as	as	IN
cord-272051-arz8r204	49	12	a	a	DT
cord-272051-arz8r204	49	13	consequence	consequence	NN
cord-272051-arz8r204	49	14	of	of	IN
cord-272051-arz8r204	49	15	the	the	DT
cord-272051-arz8r204	49	16	four	four	CD
cord-272051-arz8r204	49	17	amino	amino	NN
cord-272051-arz8r204	49	18	acid	acid	NN
cord-272051-arz8r204	49	19	substitutions	substitution	NNS
cord-272051-arz8r204	49	20	in	in	IN
cord-272051-arz8r204	49	21	the	the	DT
cord-272051-arz8r204	49	22	protease	protease	NN
cord-272051-arz8r204	49	23	gene	gene	NN
cord-272051-arz8r204	49	24	,	,	,
cord-272051-arz8r204	49	25	i.e.	i.e.	FW
cord-272051-arz8r204	49	26	,	,	,
cord-272051-arz8r204	49	27	M	M	NNP
cord-272051-arz8r204	49	28	46	46	CD
cord-272051-arz8r204	50	1	I	-PRON-	PRP
cord-272051-arz8r204	50	2	,	,	,
cord-272051-arz8r204	50	3	L	L	NNP
cord-272051-arz8r204	50	4	63	63	CD
cord-272051-arz8r204	50	5	P	p	NN
cord-272051-arz8r204	50	6	,	,	,
cord-272051-arz8r204	50	7	V	v	NN
cord-272051-arz8r204	50	8	82	82	CD
cord-272051-arz8r204	50	9	T	t	NN
cord-272051-arz8r204	50	10	,	,	,
cord-272051-arz8r204	50	11	and	and	CC
cord-272051-arz8r204	50	12	I	i	NN
cord-272051-arz8r204	50	13	84	84	CD
cord-272051-arz8r204	50	14	V	V	NNP
cord-272051-arz8r204	50	15	(	(	-LRB-
cord-272051-arz8r204	50	16	Condra	Condra	NNP
cord-272051-arz8r204	50	17	et	et	NNP
cord-272051-arz8r204	50	18	al	al	NNP
cord-272051-arz8r204	50	19	.	.	NNP
cord-272051-arz8r204	50	20	,	,	,
cord-272051-arz8r204	50	21	1995	1995	CD
cord-272051-arz8r204	50	22	)	)	-RRB-
cord-272051-arz8r204	50	23	.	.	.
cord-272051-arz8r204	51	1	First	first	RB
cord-272051-arz8r204	51	2	,	,	,
cord-272051-arz8r204	51	3	the	the	DT
cord-272051-arz8r204	51	4	real	real	JJ
cord-272051-arz8r204	51	5	resistance	resistance	NN
cord-272051-arz8r204	51	6	to	to	IN
cord-272051-arz8r204	51	7	PIs	pi	NNS
cord-272051-arz8r204	51	8	of	of	IN
cord-272051-arz8r204	51	9	PM4	PM4	NNP
cord-272051-arz8r204	51	10	HIV-1	HIV-1	NNP
cord-272051-arz8r204	51	11	was	be	VBD
cord-272051-arz8r204	51	12	checked	check	VBN
cord-272051-arz8r204	51	13	by	by	IN
cord-272051-arz8r204	51	14	evaluating	evaluate	VBG
cord-272051-arz8r204	51	15	the	the	DT
cord-272051-arz8r204	51	16	percentages	percentage	NNS
cord-272051-arz8r204	51	17	of	of	IN
cord-272051-arz8r204	51	18	CEM	CEM	NNP
cord-272051-arz8r204	51	19	GFP	GFP	NNP
cord-272051-arz8r204	51	20	infected	infected	JJ
cord-272051-arz8r204	51	21	cells	cell	NNS
cord-272051-arz8r204	51	22	6	6	CD
cord-272051-arz8r204	51	23	days	day	NNS
cord-272051-arz8r204	51	24	after	after	IN
cord-272051-arz8r204	51	25	the	the	DT
cord-272051-arz8r204	51	26	infection	infection	NN
cord-272051-arz8r204	51	27	in	in	IN
cord-272051-arz8r204	51	28	the	the	DT
cord-272051-arz8r204	51	29	presence	presence	NN
cord-272051-arz8r204	51	30	or	or	CC
cord-272051-arz8r204	51	31	not	not	RB
cord-272051-arz8r204	51	32	of	of	IN
cord-272051-arz8r204	51	33	ritonavir	ritonavir	NNS
cord-272051-arz8r204	51	34	(	(	-LRB-
cord-272051-arz8r204	51	35	Fig	Fig	NNP
cord-272051-arz8r204	51	36	.	.	.
cord-272051-arz8r204	51	37	1C	1C	NNP
cord-272051-arz8r204	51	38	)	)	-RRB-
cord-272051-arz8r204	51	39	.	.	.
cord-272051-arz8r204	52	1	Then	then	RB
cord-272051-arz8r204	52	2	,	,	,
cord-272051-arz8r204	52	3	CEM	CEM	NNP
cord-272051-arz8r204	52	4	GFP	GFP	NNP
cord-272051-arz8r204	52	5	cells	cell	NNS
cord-272051-arz8r204	52	6	treated	treat	VBN
cord-272051-arz8r204	52	7	with	with	IN
cord-272051-arz8r204	52	8	T-20	T-20	NNP
cord-272051-arz8r204	52	9	were	be	VBD
cord-272051-arz8r204	52	10	infected	infect	VBN
cord-272051-arz8r204	52	11	with	with	IN
cord-272051-arz8r204	52	12	(	(	-LRB-
cord-272051-arz8r204	52	13	VSV	VSV	NNP
cord-272051-arz8r204	52	14	-	-	HYPH
cord-272051-arz8r204	52	15	G	G	NNP
cord-272051-arz8r204	52	16	)	)	-RRB-
cord-272051-arz8r204	53	1	PM4	PM4	NNP
cord-272051-arz8r204	53	2	HIV-1	HIV-1	NNP
cord-272051-arz8r204	53	3	in	in	IN
cord-272051-arz8r204	53	4	the	the	DT
cord-272051-arz8r204	53	5	presence	presence	NN
cord-272051-arz8r204	53	6	or	or	CC
cord-272051-arz8r204	53	7	not	not	RB
cord-272051-arz8r204	53	8	of	of	IN
cord-272051-arz8r204	53	9	ritonavir	ritonavir	NNS
cord-272051-arz8r204	53	10	.	.	.
cord-272051-arz8r204	54	1	This	this	DT
cord-272051-arz8r204	54	2	experimental	experimental	JJ
cord-272051-arz8r204	54	3	setting	setting	NN
cord-272051-arz8r204	54	4	was	be	VBD
cord-272051-arz8r204	54	5	representative	representative	NN
cord-272051-arz8r204	54	6	of	of	IN
cord-272051-arz8r204	54	7	a	a	DT
cord-272051-arz8r204	54	8	singlecycle	singlecycle	NN
cord-272051-arz8r204	54	9	replication	replication	NN
cord-272051-arz8r204	54	10	assay	assay	NN
cord-272051-arz8r204	54	11	since	since	IN
cord-272051-arz8r204	54	12	T-20	T-20	NNP
cord-272051-arz8r204	54	13	disabled	disable	VBD
cord-272051-arz8r204	54	14	both	both	DT
cord-272051-arz8r204	54	15	HIV-1	HIV-1	NNP
cord-272051-arz8r204	54	16	Env	Env	NNP
cord-272051-arz8r204	54	17	-	-	HYPH
cord-272051-arz8r204	54	18	mediated	mediate	VBN
cord-272051-arz8r204	54	19	viral	viral	JJ
cord-272051-arz8r204	54	20	entry	entry	NN
cord-272051-arz8r204	54	21	and	and	CC
cord-272051-arz8r204	54	22	possible	possible	JJ
cord-272051-arz8r204	54	23	cell	cell	NN
cord-272051-arz8r204	54	24	re	re	NNS
cord-272051-arz8r204	54	25	-	-	NNS
cord-272051-arz8r204	54	26	infections	infection	NNS
cord-272051-arz8r204	54	27	.	.	.
cord-272051-arz8r204	55	1	Similarly	similarly	RB
cord-272051-arz8r204	55	2	to	to	IN
cord-272051-arz8r204	55	3	what	what	WP
cord-272051-arz8r204	55	4	observed	observe	VBD
cord-272051-arz8r204	55	5	with	with	IN
cord-272051-arz8r204	55	6	(	(	-LRB-
cord-272051-arz8r204	55	7	VSV	VSV	NNP
cord-272051-arz8r204	55	8	-	-	HYPH
cord-272051-arz8r204	55	9	G	G	NNP
cord-272051-arz8r204	55	10	)	)	-RRB-
cord-272051-arz8r204	56	1	Δenv	Δenv	NNP
cord-272051-arz8r204	56	2	HIV-1	HIV-1	NNP
cord-272051-arz8r204	56	3	strain	strain	NN
cord-272051-arz8r204	56	4	,	,	,
cord-272051-arz8r204	57	1	a	a	DT
cord-272051-arz8r204	57	2	significant	significant	JJ
cord-272051-arz8r204	57	3	inhibitory	inhibitory	JJ
cord-272051-arz8r204	57	4	effect	effect	NN
cord-272051-arz8r204	57	5	of	of	IN
cord-272051-arz8r204	57	6	ritonavir	ritonavir	NNS
cord-272051-arz8r204	57	7	on	on	IN
cord-272051-arz8r204	57	8	the	the	DT
cord-272051-arz8r204	57	9	HIV-1	HIV-1	NNP
cord-272051-arz8r204	57	10	expression	expression	NN
cord-272051-arz8r204	57	11	was	be	VBD
cord-272051-arz8r204	57	12	detected	detect	VBN
cord-272051-arz8r204	57	13	in	in	IN
cord-272051-arz8r204	57	14	(	(	-LRB-
cord-272051-arz8r204	57	15	VSV	VSV	NNP
cord-272051-arz8r204	57	16	-	-	HYPH
cord-272051-arz8r204	57	17	G	G	NNP
cord-272051-arz8r204	57	18	)	)	-RRB-
cord-272051-arz8r204	58	1	PM4	PM4	NNP
cord-272051-arz8r204	58	2	challenged	challenge	VBN
cord-272051-arz8r204	58	3	cells	cell	NNS
cord-272051-arz8r204	58	4	(	(	-LRB-
cord-272051-arz8r204	58	5	Fig	Fig	NNP
cord-272051-arz8r204	58	6	.	.	.
cord-272051-arz8r204	58	7	1D	1d	CD
cord-272051-arz8r204	58	8	)	)	-RRB-
cord-272051-arz8r204	58	9	.	.	.
cord-272051-arz8r204	59	1	This	this	DT
cord-272051-arz8r204	59	2	strongly	strongly	RB
cord-272051-arz8r204	59	3	suggests	suggest	VBZ
cord-272051-arz8r204	59	4	that	that	IN
cord-272051-arz8r204	59	5	the	the	DT
cord-272051-arz8r204	59	6	viral	viral	JJ
cord-272051-arz8r204	59	7	protease	protease	NN
cord-272051-arz8r204	59	8	activity	activity	NN
cord-272051-arz8r204	59	9	was	be	VBD
cord-272051-arz8r204	59	10	not	not	RB
cord-272051-arz8r204	59	11	involved	involve	VBN
cord-272051-arz8r204	59	12	in	in	IN
cord-272051-arz8r204	59	13	the	the	DT
cord-272051-arz8r204	59	14	PI	pi	NN
cord-272051-arz8r204	59	15	-	-	HYPH
cord-272051-arz8r204	59	16	induced	induce	VBN
cord-272051-arz8r204	59	17	inhibition	inhibition	NN
cord-272051-arz8r204	59	18	of	of	IN
cord-272051-arz8r204	59	19	(	(	-LRB-
cord-272051-arz8r204	59	20	VSV	VSV	NNP
cord-272051-arz8r204	59	21	-	-	HYPH
cord-272051-arz8r204	59	22	G	G	NNP
cord-272051-arz8r204	59	23	)	)	-RRB-
cord-272051-arz8r204	59	24	HIV-1	HIV-1	NNP
cord-272051-arz8r204	59	25	expression	expression	NN
cord-272051-arz8r204	59	26	.	.	.
cord-272051-arz8r204	60	1	Overall	overall	RB
cord-272051-arz8r204	60	2	,	,	,
cord-272051-arz8r204	60	3	these	these	DT
cord-272051-arz8r204	60	4	results	result	NNS
cord-272051-arz8r204	60	5	can	can	MD
cord-272051-arz8r204	60	6	be	be	VB
cord-272051-arz8r204	60	7	a	a	DT
cord-272051-arz8r204	60	8	consequence	consequence	NN
cord-272051-arz8r204	60	9	of	of	IN
cord-272051-arz8r204	60	10	a	a	DT
cord-272051-arz8r204	60	11	still	still	RB
cord-272051-arz8r204	60	12	unrecognized	unrecognized	JJ
cord-272051-arz8r204	60	13	inhibitory	inhibitory	JJ
cord-272051-arz8r204	60	14	effect	effect	NN
cord-272051-arz8r204	60	15	of	of	IN
cord-272051-arz8r204	60	16	PIs	pi	NNS
cord-272051-arz8r204	60	17	on	on	IN
cord-272051-arz8r204	60	18	some	some	DT
cord-272051-arz8r204	60	19	step	step	NN
cord-272051-arz8r204	60	20	of	of	IN
cord-272051-arz8r204	60	21	the	the	DT
cord-272051-arz8r204	60	22	viral	viral	JJ
cord-272051-arz8r204	60	23	entry	entry	NN
cord-272051-arz8r204	60	24	driven	drive	VBN
cord-272051-arz8r204	60	25	by	by	IN
cord-272051-arz8r204	60	26	VSV	VSV	NNP
cord-272051-arz8r204	60	27	-	-	HYPH
cord-272051-arz8r204	60	28	G.	G.	NNP
cord-272051-arz8r204	60	29	Next	Next	NNP
cord-272051-arz8r204	60	30	,	,	,
cord-272051-arz8r204	60	31	the	the	DT
cord-272051-arz8r204	60	32	possibility	possibility	NN
cord-272051-arz8r204	60	33	that	that	IN
cord-272051-arz8r204	60	34	the	the	DT
cord-272051-arz8r204	60	35	PI	PI	NNP
cord-272051-arz8r204	60	36	inhibitory	inhibitory	JJ
cord-272051-arz8r204	60	37	effect	effect	NN
cord-272051-arz8r204	60	38	was	be	VBD
cord-272051-arz8r204	60	39	operative	operative	JJ
cord-272051-arz8r204	60	40	also	also	RB
cord-272051-arz8r204	60	41	against	against	IN
cord-272051-arz8r204	60	42	VSV	VSV	NNP
cord-272051-arz8r204	60	43	was	be	VBD
cord-272051-arz8r204	60	44	investigated	investigate	VBN
cord-272051-arz8r204	60	45	.	.	.
cord-272051-arz8r204	61	1	To	to	IN
cord-272051-arz8r204	61	2	this	this	DT
cord-272051-arz8r204	61	3	end	end	NN
cord-272051-arz8r204	61	4	,	,	,
cord-272051-arz8r204	61	5	HeLa	HeLa	NNP
cord-272051-arz8r204	61	6	cells	cell	NNS
cord-272051-arz8r204	61	7	were	be	VBD
cord-272051-arz8r204	61	8	pre	pre	JJ
cord-272051-arz8r204	61	9	-	-	JJ
cord-272051-arz8r204	61	10	treated	treat	VBN
cord-272051-arz8r204	61	11	overnight	overnight	RB
cord-272051-arz8r204	61	12	with	with	IN
cord-272051-arz8r204	61	13	different	different	JJ
cord-272051-arz8r204	61	14	concentrations	concentration	NNS
cord-272051-arz8r204	61	15	of	of	IN
cord-272051-arz8r204	61	16	six	six	CD
cord-272051-arz8r204	61	17	PIs	pi	NNS
cord-272051-arz8r204	61	18	,	,	,
cord-272051-arz8r204	61	19	i.e.	i.e.	FW
cord-272051-arz8r204	61	20	,	,	,
cord-272051-arz8r204	61	21	ritonavir	ritonavir	NNP
cord-272051-arz8r204	61	22	,	,	,
cord-272051-arz8r204	61	23	indinavir	indinavir	NNP
cord-272051-arz8r204	61	24	,	,	,
cord-272051-arz8r204	61	25	saquinavir	saquinavir	NNP
cord-272051-arz8r204	61	26	,	,	,
cord-272051-arz8r204	61	27	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	61	28	,	,	,
cord-272051-arz8r204	61	29	amprenavir	amprenavir	NNP
cord-272051-arz8r204	61	30	and	and	CC
cord-272051-arz8r204	61	31	atazanavir	atazanavir	NNP
cord-272051-arz8r204	61	32	.	.	.
cord-272051-arz8r204	62	1	Then	then	RB
cord-272051-arz8r204	62	2	,	,	,
cord-272051-arz8r204	62	3	the	the	DT
cord-272051-arz8r204	62	4	cells	cell	NNS
cord-272051-arz8r204	62	5	were	be	VBD
cord-272051-arz8r204	62	6	challenged	challenge	VBN
cord-272051-arz8r204	62	7	with	with	IN
cord-272051-arz8r204	62	8	0.2	0.2	CD
cord-272051-arz8r204	62	9	m.o.i	m.o.i	NN
cord-272051-arz8r204	62	10	.	.	NN
cord-272051-arz8r204	62	11	of	of	IN
cord-272051-arz8r204	62	12	VSV	VSV	NNP
cord-272051-arz8r204	62	13	.	.	.
cord-272051-arz8r204	63	1	After	after	IN
cord-272051-arz8r204	63	2	1	1	CD
cord-272051-arz8r204	63	3	h	h	NN
cord-272051-arz8r204	63	4	of	of	IN
cord-272051-arz8r204	63	5	adsorption	adsorption	NN
cord-272051-arz8r204	63	6	in	in	IN
cord-272051-arz8r204	63	7	a	a	DT
cord-272051-arz8r204	63	8	small	small	JJ
cord-272051-arz8r204	63	9	volume	volume	NN
cord-272051-arz8r204	63	10	,	,	,
cord-272051-arz8r204	63	11	the	the	DT
cord-272051-arz8r204	63	12	viral	viral	JJ
cord-272051-arz8r204	63	13	inoculum	inoculum	NN
cord-272051-arz8r204	63	14	was	be	VBD
cord-272051-arz8r204	63	15	removed	remove	VBN
cord-272051-arz8r204	63	16	,	,	,
cord-272051-arz8r204	63	17	the	the	DT
cord-272051-arz8r204	63	18	cells	cell	NNS
cord-272051-arz8r204	63	19	extensively	extensively	RB
cord-272051-arz8r204	63	20	washed	wash	VBD
cord-272051-arz8r204	63	21	,	,	,
cord-272051-arz8r204	63	22	and	and	CC
cord-272051-arz8r204	63	23	incubated	incubate	VBN
cord-272051-arz8r204	63	24	for	for	IN
cord-272051-arz8r204	63	25	additional	additional	JJ
cord-272051-arz8r204	63	26	8	8	CD
cord-272051-arz8r204	63	27	h	h	NN
cord-272051-arz8r204	63	28	in	in	IN
cord-272051-arz8r204	63	29	the	the	DT
cord-272051-arz8r204	63	30	presence	presence	NN
cord-272051-arz8r204	63	31	of	of	IN
cord-272051-arz8r204	63	32	PIs	pi	NNS
cord-272051-arz8r204	63	33	.	.	.
cord-272051-arz8r204	64	1	Afterwards	afterwards	RB
cord-272051-arz8r204	64	2	,	,	,
cord-272051-arz8r204	64	3	the	the	DT
cord-272051-arz8r204	64	4	supernatants	supernatant	NNS
cord-272051-arz8r204	64	5	were	be	VBD
cord-272051-arz8r204	64	6	harvested	harvest	VBN
cord-272051-arz8r204	64	7	and	and	CC
cord-272051-arz8r204	64	8	titrated	titrate	VBN
cord-272051-arz8r204	64	9	for	for	IN
cord-272051-arz8r204	64	10	the	the	DT
cord-272051-arz8r204	64	11	amounts	amount	NNS
cord-272051-arz8r204	64	12	of	of	IN
cord-272051-arz8r204	64	13	infectious	infectious	JJ
cord-272051-arz8r204	64	14	VSV	VSV	NNP
cord-272051-arz8r204	64	15	.	.	.
cord-272051-arz8r204	65	1	As	as	IN
cord-272051-arz8r204	65	2	depicted	depict	VBN
cord-272051-arz8r204	65	3	in	in	IN
cord-272051-arz8r204	65	4	Figs	Figs	NNP
cord-272051-arz8r204	65	5	.	.	.
cord-272051-arz8r204	66	1	2A	2a	LS
cord-272051-arz8r204	66	2	-	-	HYPH
cord-272051-arz8r204	66	3	B	b	NN
cord-272051-arz8r204	66	4	,	,	,
cord-272051-arz8r204	66	5	a	a	DT
cord-272051-arz8r204	66	6	strong	strong	JJ
cord-272051-arz8r204	66	7	reduction	reduction	NN
cord-272051-arz8r204	66	8	of	of	IN
cord-272051-arz8r204	66	9	VSV	VSV	NNP
cord-272051-arz8r204	66	10	replication	replication	NN
cord-272051-arz8r204	66	11	(	(	-LRB-
cord-272051-arz8r204	66	12	more	more	JJR
cord-272051-arz8r204	66	13	than	than	IN
cord-272051-arz8r204	66	14	2	2	CD
cord-272051-arz8r204	66	15	logs	log	NNS
cord-272051-arz8r204	66	16	)	)	-RRB-
cord-272051-arz8r204	66	17	was	be	VBD
cord-272051-arz8r204	66	18	observed	observe	VBN
cord-272051-arz8r204	66	19	when	when	WRB
cord-272051-arz8r204	66	20	the	the	DT
cord-272051-arz8r204	66	21	cells	cell	NNS
cord-272051-arz8r204	66	22	were	be	VBD
cord-272051-arz8r204	66	23	treated	treat	VBN
cord-272051-arz8r204	66	24	with	with	IN
cord-272051-arz8r204	66	25	2.5	2.5	CD
cord-272051-arz8r204	66	26	μM	μm	CD
cord-272051-arz8r204	66	27	saquinavir	saquinavir	NNS
cord-272051-arz8r204	66	28	and	and	CC
cord-272051-arz8r204	66	29	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	66	30	.	.	.
cord-272051-arz8r204	67	1	The	the	DT
cord-272051-arz8r204	67	2	inhibitory	inhibitory	JJ
cord-272051-arz8r204	67	3	effect	effect	NN
cord-272051-arz8r204	67	4	appeared	appear	VBD
cord-272051-arz8r204	67	5	more	more	RBR
cord-272051-arz8r204	67	6	potent	potent	JJ
cord-272051-arz8r204	67	7	(	(	-LRB-
cord-272051-arz8r204	67	8	up	up	IN
cord-272051-arz8r204	67	9	to	to	IN
cord-272051-arz8r204	67	10	about	about	RB
cord-272051-arz8r204	67	11	4	4	CD
cord-272051-arz8r204	67	12	logs	log	NNS
cord-272051-arz8r204	67	13	)	)	-RRB-
cord-272051-arz8r204	67	14	by	by	IN
cord-272051-arz8r204	67	15	increasing	increase	VBG
cord-272051-arz8r204	67	16	the	the	DT
cord-272051-arz8r204	67	17	concentration	concentration	NN
cord-272051-arz8r204	67	18	of	of	IN
cord-272051-arz8r204	67	19	these	these	DT
cord-272051-arz8r204	67	20	PIs	pi	NNS
cord-272051-arz8r204	67	21	to	to	IN
cord-272051-arz8r204	67	22	10	10	CD
cord-272051-arz8r204	67	23	μM	μm	NN
cord-272051-arz8r204	67	24	,	,	,
cord-272051-arz8r204	67	25	and	and	CC
cord-272051-arz8r204	67	26	remained	remain	VBD
cord-272051-arz8r204	67	27	significant	significant	JJ
cord-272051-arz8r204	67	28	(	(	-LRB-
cord-272051-arz8r204	67	29	i.e.	i.e.	FW
cord-272051-arz8r204	67	30	,	,	,
cord-272051-arz8r204	67	31	more	more	JJR
cord-272051-arz8r204	67	32	than	than	IN
cord-272051-arz8r204	67	33	1	1	CD
cord-272051-arz8r204	67	34	log	log	NN
cord-272051-arz8r204	67	35	)	)	-RRB-
cord-272051-arz8r204	67	36	by	by	IN
cord-272051-arz8r204	67	37	increasing	increase	VBG
cord-272051-arz8r204	67	38	the	the	DT
cord-272051-arz8r204	67	39	m.o.i	m.o.i	NN
cord-272051-arz8r204	67	40	.	.	.
cord-272051-arz8r204	67	41	up	up	IN
cord-272051-arz8r204	67	42	until	until	IN
cord-272051-arz8r204	67	43	1	1	CD
cord-272051-arz8r204	67	44	(	(	-LRB-
cord-272051-arz8r204	67	45	not	not	RB
cord-272051-arz8r204	67	46	shown	show	VBN
cord-272051-arz8r204	67	47	)	)	-RRB-
cord-272051-arz8r204	67	48	.	.	.
cord-272051-arz8r204	68	1	No	no	DT
cord-272051-arz8r204	68	2	differences	difference	NNS
cord-272051-arz8r204	68	3	were	be	VBD
cord-272051-arz8r204	68	4	observed	observe	VBN
cord-272051-arz8r204	68	5	when	when	WRB
cord-272051-arz8r204	68	6	the	the	DT
cord-272051-arz8r204	68	7	PIs	pi	NNS
cord-272051-arz8r204	68	8	pretreatment	pretreatment	NN
cord-272051-arz8r204	68	9	was	be	VBD
cord-272051-arz8r204	68	10	carried	carry	VBN
cord-272051-arz8r204	68	11	out	out	RP
cord-272051-arz8r204	68	12	for	for	IN
cord-272051-arz8r204	68	13	2	2	CD
cord-272051-arz8r204	68	14	,	,	,
cord-272051-arz8r204	68	15	4	4	CD
cord-272051-arz8r204	68	16	,	,	,
cord-272051-arz8r204	68	17	6	6	CD
cord-272051-arz8r204	68	18	,	,	,
cord-272051-arz8r204	68	19	or	or	CC
cord-272051-arz8r204	68	20	8	8	CD
cord-272051-arz8r204	68	21	h	h	NN
cord-272051-arz8r204	68	22	(	(	-LRB-
cord-272051-arz8r204	68	23	not	not	RB
cord-272051-arz8r204	68	24	shown	show	VBN
cord-272051-arz8r204	68	25	)	)	-RRB-
cord-272051-arz8r204	68	26	.	.	.
cord-272051-arz8r204	69	1	As	as	IN
cord-272051-arz8r204	69	2	calculated	calculate	VBN
cord-272051-arz8r204	69	3	through	through	IN
cord-272051-arz8r204	69	4	a	a	DT
cord-272051-arz8r204	69	5	wide	wide	JJ
cord-272051-arz8r204	69	6	dose	dose	NN
cord-272051-arz8r204	69	7	-	-	HYPH
cord-272051-arz8r204	69	8	response	response	NN
cord-272051-arz8r204	69	9	curve	curve	NN
cord-272051-arz8r204	69	10	,	,	,
cord-272051-arz8r204	69	11	the	the	DT
cord-272051-arz8r204	69	12	50	50	CD
cord-272051-arz8r204	69	13	%	%	NN
cord-272051-arz8r204	69	14	inhibitory	inhibitory	JJ
cord-272051-arz8r204	69	15	concentration	concentration	NN
cord-272051-arz8r204	69	16	(	(	-LRB-
cord-272051-arz8r204	69	17	IC	IC	NNP
cord-272051-arz8r204	69	18	50	50	CD
cord-272051-arz8r204	69	19	)	)	-RRB-
cord-272051-arz8r204	69	20	values	value	NNS
cord-272051-arz8r204	69	21	of	of	IN
cord-272051-arz8r204	69	22	saquinavir	saquinavir	NNS
cord-272051-arz8r204	69	23	and	and	CC
cord-272051-arz8r204	69	24	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	69	25	were	be	VBD
cord-272051-arz8r204	69	26	1.4	1.4	CD
cord-272051-arz8r204	69	27	and	and	CC
cord-272051-arz8r204	69	28	1.1	1.1	CD
cord-272051-arz8r204	69	29	μM	μm	CD
cord-272051-arz8r204	69	30	,	,	,
cord-272051-arz8r204	69	31	respectively	respectively	RB
cord-272051-arz8r204	69	32	.	.	.
cord-272051-arz8r204	70	1	On	on	IN
cord-272051-arz8r204	70	2	the	the	DT
cord-272051-arz8r204	70	3	other	other	JJ
cord-272051-arz8r204	70	4	hand	hand	NN
cord-272051-arz8r204	70	5	,	,	,
cord-272051-arz8r204	70	6	significant	significant	JJ
cord-272051-arz8r204	70	7	inhibition	inhibition	NN
cord-272051-arz8r204	70	8	of	of	IN
cord-272051-arz8r204	70	9	viral	viral	JJ
cord-272051-arz8r204	70	10	replication	replication	NN
cord-272051-arz8r204	70	11	were	be	VBD
cord-272051-arz8r204	70	12	detected	detect	VBN
cord-272051-arz8r204	70	13	in	in	IN
cord-272051-arz8r204	70	14	ritonavir	ritonavir	NNS
cord-272051-arz8r204	70	15	and	and	CC
cord-272051-arz8r204	70	16	indinavir	indinavir	NNP
cord-272051-arz8r204	70	17	treated	treat	VBD
cord-272051-arz8r204	70	18	cells	cell	NNS
cord-272051-arz8r204	70	19	starting	start	VBG
cord-272051-arz8r204	70	20	to	to	IN
cord-272051-arz8r204	70	21	the	the	DT
cord-272051-arz8r204	70	22	concentrations	concentration	NNS
cord-272051-arz8r204	70	23	of	of	IN
cord-272051-arz8r204	70	24	20	20	CD
cord-272051-arz8r204	70	25	-	-	SYM
cord-272051-arz8r204	70	26	30	30	CD
cord-272051-arz8r204	71	1	μM	μM	NNP
cord-272051-arz8r204	71	2	(	(	-LRB-
cord-272051-arz8r204	71	3	Fig	Fig	NNP
cord-272051-arz8r204	71	4	.	.	.
cord-272051-arz8r204	71	5	2B	2b	CD
cord-272051-arz8r204	71	6	)	)	-RRB-
cord-272051-arz8r204	71	7	.	.	.
cord-272051-arz8r204	72	1	The	the	DT
cord-272051-arz8r204	72	2	IC	IC	NNP
cord-272051-arz8r204	72	3	50	50	CD
cord-272051-arz8r204	72	4	of	of	IN
cord-272051-arz8r204	72	5	ritonavir	ritonavir	NNS
cord-272051-arz8r204	72	6	and	and	CC
cord-272051-arz8r204	72	7	saquinavir	saquinavir	NNP
cord-272051-arz8r204	72	8	were	be	VBD
cord-272051-arz8r204	72	9	16	16	CD
cord-272051-arz8r204	72	10	and	and	CC
cord-272051-arz8r204	72	11	14	14	CD
cord-272051-arz8r204	72	12	μM	μm	CD
cord-272051-arz8r204	72	13	,	,	,
cord-272051-arz8r204	72	14	respectively	respectively	RB
cord-272051-arz8r204	72	15	.	.	.
cord-272051-arz8r204	73	1	The	the	DT
cord-272051-arz8r204	73	2	idea	idea	NN
cord-272051-arz8r204	73	3	that	that	IN
cord-272051-arz8r204	73	4	PIs	pi	NNS
cord-272051-arz8r204	73	5	negatively	negatively	RB
cord-272051-arz8r204	73	6	affect	affect	VBP
cord-272051-arz8r204	73	7	the	the	DT
cord-272051-arz8r204	73	8	VSV	VSV	NNP
cord-272051-arz8r204	73	9	replication	replication	NN
cord-272051-arz8r204	73	10	was	be	VBD
cord-272051-arz8r204	73	11	further	further	RB
cord-272051-arz8r204	73	12	strengthened	strengthen	VBN
cord-272051-arz8r204	73	13	by	by	IN
cord-272051-arz8r204	73	14	performing	perform	VBG
cord-272051-arz8r204	73	15	a	a	DT
cord-272051-arz8r204	73	16	set	set	NN
cord-272051-arz8r204	73	17	of	of	IN
cord-272051-arz8r204	73	18	more	more	RBR
cord-272051-arz8r204	73	19	stringent	stringent	JJ
cord-272051-arz8r204	73	20	challenge	challenge	NN
cord-272051-arz8r204	73	21	experiments	experiment	NNS
cord-272051-arz8r204	73	22	.	.	.
cord-272051-arz8r204	74	1	In	in	IN
cord-272051-arz8r204	74	2	detail	detail	NN
cord-272051-arz8r204	74	3	,	,	,
cord-272051-arz8r204	74	4	HeLa	HeLa	NNP
cord-272051-arz8r204	74	5	cells	cell	NNS
cord-272051-arz8r204	74	6	were	be	VBD
cord-272051-arz8r204	74	7	pre	pre	JJ
cord-272051-arz8r204	74	8	-	-	VBN
cord-272051-arz8r204	74	9	treated	treat	VBN
cord-272051-arz8r204	74	10	with	with	IN
cord-272051-arz8r204	74	11	optimal	optimal	JJ
cord-272051-arz8r204	74	12	concentrations	concentration	NNS
cord-272051-arz8r204	74	13	of	of	IN
cord-272051-arz8r204	74	14	the	the	DT
cord-272051-arz8r204	74	15	most	most	RBS
cord-272051-arz8r204	74	16	effective	effective	JJ
cord-272051-arz8r204	74	17	PIs	pi	NNS
cord-272051-arz8r204	74	18	,	,	,
cord-272051-arz8r204	74	19	and	and	CC
cord-272051-arz8r204	74	20	then	then	RB
cord-272051-arz8r204	74	21	infected	infect	VBN
cord-272051-arz8r204	74	22	with	with	IN
cord-272051-arz8r204	74	23	2-fold	2-fold	DT
cord-272051-arz8r204	74	24	decreasing	decrease	VBG
cord-272051-arz8r204	74	25	amounts	amount	NNS
cord-272051-arz8r204	74	26	of	of	IN
cord-272051-arz8r204	74	27	VSV	VSV	NNP
cord-272051-arz8r204	74	28	starting	start	VBG
cord-272051-arz8r204	74	29	to	to	IN
cord-272051-arz8r204	74	30	m.o.i	m.o.i	NNP
cord-272051-arz8r204	74	31	.	.	NNP
cord-272051-arz8r204	74	32	2	2	CD
cord-272051-arz8r204	74	33	.	.	.
cord-272051-arz8r204	75	1	The	the	DT
cord-272051-arz8r204	75	2	cytopathic	cytopathic	JJ
cord-272051-arz8r204	75	3	effect	effect	NN
cord-272051-arz8r204	75	4	was	be	VBD
cord-272051-arz8r204	75	5	monitored	monitor	VBN
cord-272051-arz8r204	75	6	24	24	CD
cord-272051-arz8r204	75	7	h	h	NN
cord-272051-arz8r204	75	8	post	post	NN
cord-272051-arz8r204	75	9	challenge	challenge	NN
cord-272051-arz8r204	75	10	.	.	.
cord-272051-arz8r204	76	1	The	the	DT
cord-272051-arz8r204	76	2	outcome	outcome	NN
cord-272051-arz8r204	76	3	of	of	IN
cord-272051-arz8r204	76	4	this	this	DT
cord-272051-arz8r204	76	5	assay	assay	NN
cord-272051-arz8r204	76	6	was	be	VBD
cord-272051-arz8r204	76	7	scored	score	VBN
cord-272051-arz8r204	76	8	in	in	IN
cord-272051-arz8r204	76	9	terms	term	NNS
cord-272051-arz8r204	76	10	of	of	IN
cord-272051-arz8r204	76	11	the	the	DT
cord-272051-arz8r204	76	12	viral	viral	JJ
cord-272051-arz8r204	76	13	dilutions	dilution	NNS
cord-272051-arz8r204	76	14	no	no	RB
cord-272051-arz8r204	76	15	more	more	RBR
cord-272051-arz8r204	76	16	able	able	JJ
cord-272051-arz8r204	76	17	to	to	TO
cord-272051-arz8r204	76	18	induce	induce	VB
cord-272051-arz8r204	76	19	cytopathic	cytopathic	JJ
cord-272051-arz8r204	76	20	effect	effect	NN
cord-272051-arz8r204	76	21	.	.	.
cord-272051-arz8r204	77	1	Notably	notably	RB
cord-272051-arz8r204	77	2	,	,	,
cord-272051-arz8r204	77	3	in	in	IN
cord-272051-arz8r204	77	4	these	these	DT
cord-272051-arz8r204	77	5	conditions	condition	NNS
cord-272051-arz8r204	77	6	an	an	DT
cord-272051-arz8r204	77	7	about	about	IN
cord-272051-arz8r204	77	8	30-fold	30-fold	JJ
cord-272051-arz8r204	77	9	reduction	reduction	NN
cord-272051-arz8r204	77	10	of	of	IN
cord-272051-arz8r204	77	11	VSV	VSV	NNP
cord-272051-arz8r204	77	12	infectivity	infectivity	NN
cord-272051-arz8r204	77	13	was	be	VBD
cord-272051-arz8r204	77	14	observed	observe	VBN
cord-272051-arz8r204	77	15	in	in	IN
cord-272051-arz8r204	77	16	cells	cell	NNS
cord-272051-arz8r204	77	17	treated	treat	VBN
cord-272051-arz8r204	77	18	with	with	IN
cord-272051-arz8r204	77	19	saquinavir	saquinavir	NNS
cord-272051-arz8r204	77	20	or	or	CC
cord-272051-arz8r204	77	21	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	77	22	(	(	-LRB-
cord-272051-arz8r204	77	23	Fig	Fig	NNP
cord-272051-arz8r204	77	24	.	.	.
cord-272051-arz8r204	77	25	2C	2C	NNP
cord-272051-arz8r204	77	26	)	)	-RRB-
cord-272051-arz8r204	77	27	.	.	.
cord-272051-arz8r204	78	1	Since	since	IN
cord-272051-arz8r204	78	2	the	the	DT
cord-272051-arz8r204	78	3	average	average	JJ
cord-272051-arz8r204	78	4	replication	replication	NN
cord-272051-arz8r204	78	5	time	time	NN
cord-272051-arz8r204	78	6	of	of	IN
cord-272051-arz8r204	78	7	VSV	VSV	NNP
cord-272051-arz8r204	78	8	is	be	VBZ
cord-272051-arz8r204	78	9	6	6	CD
cord-272051-arz8r204	78	10	-	-	SYM
cord-272051-arz8r204	78	11	8	8	CD
cord-272051-arz8r204	78	12	h	h	NN
cord-272051-arz8r204	78	13	(	(	-LRB-
cord-272051-arz8r204	78	14	Whelan	Whelan	NNP
cord-272051-arz8r204	78	15	et	et	NNP
cord-272051-arz8r204	78	16	al	al	NNP
cord-272051-arz8r204	78	17	.	.	NNP
cord-272051-arz8r204	78	18	,	,	,
cord-272051-arz8r204	78	19	2004	2004	CD
cord-272051-arz8r204	78	20	)	)	-RRB-
cord-272051-arz8r204	78	21	,	,	,
cord-272051-arz8r204	78	22	in	in	IN
cord-272051-arz8r204	78	23	this	this	DT
cord-272051-arz8r204	78	24	experimental	experimental	JJ
cord-272051-arz8r204	78	25	setting	setting	NN
cord-272051-arz8r204	78	26	VSV	VSV	NNP
cord-272051-arz8r204	78	27	was	be	VBD
cord-272051-arz8r204	78	28	expected	expect	VBN
cord-272051-arz8r204	78	29	to	to	TO
cord-272051-arz8r204	78	30	complete	complete	VB
cord-272051-arz8r204	78	31	at	at	RB
cord-272051-arz8r204	78	32	least	least	RBS
cord-272051-arz8r204	78	33	three	three	CD
cord-272051-arz8r204	78	34	replication	replication	NN
cord-272051-arz8r204	78	35	cycles	cycle	NNS
cord-272051-arz8r204	78	36	in	in	IN
cord-272051-arz8r204	78	37	control	control	NN
cord-272051-arz8r204	78	38	cells	cell	NNS
cord-272051-arz8r204	78	39	.	.	.
cord-272051-arz8r204	79	1	Then	then	RB
cord-272051-arz8r204	79	2	,	,	,
cord-272051-arz8r204	79	3	it	-PRON-	PRP
cord-272051-arz8r204	79	4	was	be	VBD
cord-272051-arz8r204	79	5	controlled	control	VBN
cord-272051-arz8r204	79	6	whether	whether	IN
cord-272051-arz8r204	79	7	the	the	DT
cord-272051-arz8r204	79	8	antiviral	antiviral	JJ
cord-272051-arz8r204	79	9	effect	effect	NN
cord-272051-arz8r204	79	10	was	be	VBD
cord-272051-arz8r204	79	11	a	a	DT
cord-272051-arz8r204	79	12	consequence	consequence	NN
cord-272051-arz8r204	79	13	of	of	IN
cord-272051-arz8r204	79	14	a	a	DT
cord-272051-arz8r204	79	15	general	general	JJ
cord-272051-arz8r204	79	16	cytotoxicity	cytotoxicity	NN
cord-272051-arz8r204	79	17	of	of	IN
cord-272051-arz8r204	79	18	PIs	pi	NNS
cord-272051-arz8r204	79	19	.	.	.
cord-272051-arz8r204	80	1	To	to	IN
cord-272051-arz8r204	80	2	this	this	DT
cord-272051-arz8r204	80	3	aim	aim	NN
cord-272051-arz8r204	80	4	,	,	,
cord-272051-arz8r204	80	5	cells	cell	NNS
cord-272051-arz8r204	80	6	were	be	VBD
cord-272051-arz8r204	80	7	treated	treat	VBN
cord-272051-arz8r204	80	8	with	with	IN
cord-272051-arz8r204	80	9	different	different	JJ
cord-272051-arz8r204	80	10	PI	pi	NN
cord-272051-arz8r204	80	11	concentrations	concentration	NNS
cord-272051-arz8r204	80	12	for	for	IN
cord-272051-arz8r204	80	13	8	8	CD
cord-272051-arz8r204	80	14	h	h	NN
cord-272051-arz8r204	80	15	,	,	,
cord-272051-arz8r204	80	16	then	then	RB
cord-272051-arz8r204	80	17	labeled	label	VBN
cord-272051-arz8r204	80	18	with	with	IN
cord-272051-arz8r204	80	19	carboxyfluorescein	carboxyfluorescein	NNP
cord-272051-arz8r204	80	20	diacetate	diacetate	NNP
cord-272051-arz8r204	80	21	succinimidyl	succinimidyl	NNP
cord-272051-arz8r204	80	22	ester	ester	NNP
cord-272051-arz8r204	80	23	(	(	-LRB-
cord-272051-arz8r204	80	24	CFSE	CFSE	NNP
cord-272051-arz8r204	80	25	)	)	-RRB-
cord-272051-arz8r204	80	26	,	,	,
cord-272051-arz8r204	80	27	and	and	CC
cord-272051-arz8r204	80	28	thereafter	thereafter	RB
cord-272051-arz8r204	80	29	refed	refed	NNP
cord-272051-arz8r204	80	30	with	with	IN
cord-272051-arz8r204	80	31	complete	complete	JJ
cord-272051-arz8r204	80	32	medium	medium	NN
cord-272051-arz8r204	80	33	in	in	IN
cord-272051-arz8r204	80	34	the	the	DT
cord-272051-arz8r204	80	35	presence	presence	NN
cord-272051-arz8r204	80	36	of	of	IN
cord-272051-arz8r204	80	37	PIs	pi	NNS
cord-272051-arz8r204	80	38	.	.	.
cord-272051-arz8r204	81	1	CFSE	CFSE	NNP
cord-272051-arz8r204	81	2	was	be	VBD
cord-272051-arz8r204	81	3	expected	expect	VBN
cord-272051-arz8r204	81	4	to	to	TO
cord-272051-arz8r204	81	5	be	be	VB
cord-272051-arz8r204	81	6	equally	equally	RB
cord-272051-arz8r204	81	7	distributed	distribute	VBN
cord-272051-arz8r204	81	8	upon	upon	IN
cord-272051-arz8r204	81	9	cell	cell	NN
cord-272051-arz8r204	81	10	division	division	NN
cord-272051-arz8r204	81	11	,	,	,
cord-272051-arz8r204	81	12	then	then	RB
cord-272051-arz8r204	81	13	resulting	result	VBG
cord-272051-arz8r204	81	14	in	in	IN
cord-272051-arz8r204	81	15	a	a	DT
cord-272051-arz8r204	81	16	halving	halving	NN
cord-272051-arz8r204	81	17	of	of	IN
cord-272051-arz8r204	81	18	the	the	DT
cord-272051-arz8r204	81	19	overall	overall	JJ
cord-272051-arz8r204	81	20	cell	cell	NN
cord-272051-arz8r204	81	21	fluorescence	fluorescence	NN
cord-272051-arz8r204	81	22	after	after	IN
cord-272051-arz8r204	81	23	cell	cell	NN
cord-272051-arz8r204	81	24	duplication	duplication	NN
cord-272051-arz8r204	81	25	.	.	.
cord-272051-arz8r204	82	1	Cytotoxic	cytotoxic	JJ
cord-272051-arz8r204	82	2	effects	effect	NNS
cord-272051-arz8r204	82	3	were	be	VBD
cord-272051-arz8r204	82	4	measured	measure	VBN
cord-272051-arz8r204	82	5	in	in	IN
cord-272051-arz8r204	82	6	terms	term	NNS
cord-272051-arz8r204	82	7	of	of	IN
cord-272051-arz8r204	82	8	inhibition	inhibition	NN
cord-272051-arz8r204	82	9	of	of	IN
cord-272051-arz8r204	82	10	the	the	DT
cord-272051-arz8r204	82	11	cell	cell	NN
cord-272051-arz8r204	82	12	duplication	duplication	NN
cord-272051-arz8r204	82	13	as	as	IN
cord-272051-arz8r204	82	14	detectable	detectable	JJ
cord-272051-arz8r204	82	15	by	by	IN
cord-272051-arz8r204	82	16	the	the	DT
cord-272051-arz8r204	82	17	impairment	impairment	NN
cord-272051-arz8r204	82	18	of	of	IN
cord-272051-arz8r204	82	19	the	the	DT
cord-272051-arz8r204	82	20	halving	halving	NN
cord-272051-arz8r204	82	21	of	of	IN
cord-272051-arz8r204	82	22	the	the	DT
cord-272051-arz8r204	82	23	CFSE	CFSE	NNP
cord-272051-arz8r204	82	24	-	-	HYPH
cord-272051-arz8r204	82	25	associated	associate	VBN
cord-272051-arz8r204	82	26	cell	cell	NN
cord-272051-arz8r204	82	27	fluorescence	fluorescence	NN
cord-272051-arz8r204	82	28	.	.	.
cord-272051-arz8r204	83	1	Fig	Fig	NNP
cord-272051-arz8r204	83	2	.	.	.
cord-272051-arz8r204	84	1	2D	2D	NNP
cord-272051-arz8r204	84	2	reports	report	VBZ
cord-272051-arz8r204	84	3	the	the	DT
cord-272051-arz8r204	84	4	mean	mean	JJ
cord-272051-arz8r204	84	5	fluorescence	fluorescence	NN
cord-272051-arz8r204	84	6	intensities	intensity	NNS
cord-272051-arz8r204	84	7	(	(	-LRB-
cord-272051-arz8r204	84	8	MFIs	mfi	NNS
cord-272051-arz8r204	84	9	)	)	-RRB-
cord-272051-arz8r204	84	10	measured	measure	VBN
cord-272051-arz8r204	84	11	in	in	IN
cord-272051-arz8r204	84	12	cell	cell	NN
cord-272051-arz8r204	84	13	cultures	culture	NNS
cord-272051-arz8r204	84	14	treated	treat	VBN
cord-272051-arz8r204	84	15	with	with	IN
cord-272051-arz8r204	84	16	different	different	JJ
cord-272051-arz8r204	84	17	concentrations	concentration	NNS
cord-272051-arz8r204	84	18	of	of	IN
cord-272051-arz8r204	84	19	the	the	DT
cord-272051-arz8r204	84	20	PIs	pi	NNS
cord-272051-arz8r204	84	21	active	active	JJ
cord-272051-arz8r204	84	22	against	against	IN
cord-272051-arz8r204	84	23	VSV	VSV	NNP
cord-272051-arz8r204	84	24	replication	replication	NN
cord-272051-arz8r204	84	25	.	.	.
cord-272051-arz8r204	85	1	Block	block	NN
cord-272051-arz8r204	85	2	of	of	IN
cord-272051-arz8r204	85	3	cell	cell	NN
cord-272051-arz8r204	85	4	duplication	duplication	NN
cord-272051-arz8r204	85	5	with	with	IN
cord-272051-arz8r204	85	6	cell	cell	NN
cord-272051-arz8r204	85	7	mortality	mortality	NN
cord-272051-arz8r204	85	8	over	over	IN
cord-272051-arz8r204	85	9	20	20	CD
cord-272051-arz8r204	85	10	%	%	NN
cord-272051-arz8r204	85	11	has	have	VBZ
cord-272051-arz8r204	85	12	been	be	VBN
cord-272051-arz8r204	85	13	detected	detect	VBN
cord-272051-arz8r204	85	14	using	use	VBG
cord-272051-arz8r204	85	15	100	100	CD
cord-272051-arz8r204	85	16	μM	μM	NNP
cord-272051-arz8r204	85	17	ritonavir	ritonavir	NNS
cord-272051-arz8r204	85	18	,	,	,
cord-272051-arz8r204	85	19	saquinavir	saquinavir	NNP
cord-272051-arz8r204	85	20	,	,	,
cord-272051-arz8r204	85	21	and	and	CC
cord-272051-arz8r204	85	22	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	85	23	,	,	,
cord-272051-arz8r204	85	24	while	while	IN
cord-272051-arz8r204	85	25	indinavir	indinavir	NNP
cord-272051-arz8r204	85	26	showed	show	VBD
cord-272051-arz8r204	85	27	a	a	DT
cord-272051-arz8r204	85	28	much	much	RB
cord-272051-arz8r204	85	29	lower	low	JJR
cord-272051-arz8r204	85	30	cytotoxic	cytotoxic	JJ
cord-272051-arz8r204	85	31	effect	effect	NN
cord-272051-arz8r204	85	32	.	.	.
cord-272051-arz8r204	86	1	The	the	DT
cord-272051-arz8r204	86	2	50	50	CD
cord-272051-arz8r204	86	3	%	%	NN
cord-272051-arz8r204	86	4	cytotoxic	cytotoxic	JJ
cord-272051-arz8r204	86	5	concentration	concentration	NN
cord-272051-arz8r204	86	6	(	(	-LRB-
cord-272051-arz8r204	86	7	CC	CC	NNP
cord-272051-arz8r204	86	8	50	50	CD
cord-272051-arz8r204	86	9	)	)	-RRB-
cord-272051-arz8r204	86	10	values	value	NNS
cord-272051-arz8r204	86	11	of	of	IN
cord-272051-arz8r204	86	12	PIs	pi	NNS
cord-272051-arz8r204	86	13	(	(	-LRB-
cord-272051-arz8r204	86	14	Fig	Fig	NNP
cord-272051-arz8r204	86	15	.	.	.
cord-272051-arz8r204	87	1	2D	2D	NNP
cord-272051-arz8r204	87	2	,	,	,
cord-272051-arz8r204	87	3	insert	insert	NNP
cord-272051-arz8r204	87	4	)	)	-RRB-
cord-272051-arz8r204	87	5	were	be	VBD
cord-272051-arz8r204	87	6	calculated	calculate	VBN
cord-272051-arz8r204	87	7	as	as	IN
cord-272051-arz8r204	87	8	the	the	DT
cord-272051-arz8r204	87	9	doses	dose	NNS
cord-272051-arz8r204	87	10	inhibiting	inhibit	VBG
cord-272051-arz8r204	87	11	by	by	IN
cord-272051-arz8r204	87	12	50	50	CD
cord-272051-arz8r204	87	13	%	%	NN
cord-272051-arz8r204	87	14	the	the	DT
cord-272051-arz8r204	87	15	fluorescence	fluorescence	NN
cord-272051-arz8r204	87	16	halving	halving	NN
cord-272051-arz8r204	87	17	,	,	,
cord-272051-arz8r204	87	18	expectedly	expectedly	RB
cord-272051-arz8r204	87	19	a	a	DT
cord-272051-arz8r204	87	20	consequence	consequence	NN
cord-272051-arz8r204	87	21	of	of	IN
cord-272051-arz8r204	87	22	the	the	DT
cord-272051-arz8r204	87	23	block	block	NN
cord-272051-arz8r204	87	24	of	of	IN
cord-272051-arz8r204	87	25	the	the	DT
cord-272051-arz8r204	87	26	duplication	duplication	NN
cord-272051-arz8r204	87	27	in	in	IN
cord-272051-arz8r204	87	28	50	50	CD
cord-272051-arz8r204	87	29	%	%	NN
cord-272051-arz8r204	87	30	of	of	IN
cord-272051-arz8r204	87	31	cells	cell	NNS
cord-272051-arz8r204	87	32	.	.	.
cord-272051-arz8r204	88	1	The	the	DT
cord-272051-arz8r204	88	2	therapeutic	therapeutic	JJ
cord-272051-arz8r204	88	3	indexes	index	NNS
cord-272051-arz8r204	88	4	(	(	-LRB-
cord-272051-arz8r204	88	5	i.e.	i.e.	FW
cord-272051-arz8r204	88	6	,	,	,
cord-272051-arz8r204	88	7	CC	CC	NNP
cord-272051-arz8r204	88	8	50	50	CD
cord-272051-arz8r204	88	9	divided	divide	VBN
cord-272051-arz8r204	88	10	by	by	IN
cord-272051-arz8r204	88	11	IC	IC	NNP
cord-272051-arz8r204	88	12	50	50	CD
cord-272051-arz8r204	88	13	)	)	-RRB-
cord-272051-arz8r204	88	14	appeared	appear	VBD
cord-272051-arz8r204	88	15	higher	high	JJR
cord-272051-arz8r204	88	16	than	than	IN
cord-272051-arz8r204	88	17	22	22	CD
cord-272051-arz8r204	88	18	for	for	IN
cord-272051-arz8r204	88	19	both	both	DT
cord-272051-arz8r204	88	20	saquinavir	saquinavir	NNS
cord-272051-arz8r204	88	21	and	and	CC
cord-272051-arz8r204	88	22	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	88	23	.	.	.
cord-272051-arz8r204	89	1	This	this	DT
cord-272051-arz8r204	89	2	is	be	VBZ
cord-272051-arz8r204	89	3	suggestive	suggestive	JJ
cord-272051-arz8r204	89	4	of	of	IN
cord-272051-arz8r204	89	5	specific	specific	JJ
cord-272051-arz8r204	89	6	antiviral	antiviral	JJ
cord-272051-arz8r204	89	7	effects	effect	NNS
cord-272051-arz8r204	89	8	for	for	IN
cord-272051-arz8r204	89	9	these	these	DT
cord-272051-arz8r204	89	10	PIs	pi	NNS
cord-272051-arz8r204	89	11	.	.	.
cord-272051-arz8r204	90	1	Taken	take	VBN
cord-272051-arz8r204	90	2	together	together	RB
cord-272051-arz8r204	90	3	,	,	,
cord-272051-arz8r204	90	4	these	these	DT
cord-272051-arz8r204	90	5	data	datum	NNS
cord-272051-arz8r204	90	6	reveal	reveal	VBP
cord-272051-arz8r204	90	7	a	a	DT
cord-272051-arz8r204	90	8	previously	previously	RB
cord-272051-arz8r204	90	9	unrecognized	unrecognized	JJ
cord-272051-arz8r204	90	10	effect	effect	NN
cord-272051-arz8r204	90	11	of	of	IN
cord-272051-arz8r204	90	12	PIs	pi	NNS
cord-272051-arz8r204	90	13	against	against	IN
cord-272051-arz8r204	90	14	VSV	VSV	NNP
cord-272051-arz8r204	90	15	.	.	.
cord-272051-arz8r204	91	1	In	in	IN
cord-272051-arz8r204	91	2	addition	addition	NN
cord-272051-arz8r204	91	3	,	,	,
cord-272051-arz8r204	91	4	these	these	DT
cord-272051-arz8r204	91	5	results	result	NNS
cord-272051-arz8r204	91	6	support	support	VBP
cord-272051-arz8r204	91	7	the	the	DT
cord-272051-arz8r204	91	8	idea	idea	NN
cord-272051-arz8r204	91	9	that	that	IN
cord-272051-arz8r204	91	10	the	the	DT
cord-272051-arz8r204	91	11	PI	pi	NN
cord-272051-arz8r204	91	12	-	-	HYPH
cord-272051-arz8r204	91	13	induced	induce	VBN
cord-272051-arz8r204	91	14	reduction	reduction	NN
cord-272051-arz8r204	91	15	of	of	IN
cord-272051-arz8r204	91	16	(	(	-LRB-
cord-272051-arz8r204	91	17	VSV	VSV	NNP
cord-272051-arz8r204	91	18	-	-	HYPH
cord-272051-arz8r204	91	19	G	G	NNP
cord-272051-arz8r204	91	20	)	)	-RRB-
cord-272051-arz8r204	91	21	HIV-1	HIV-1	NNP
cord-272051-arz8r204	91	22	expression	expression	NN
cord-272051-arz8r204	91	23	is	be	VBZ
cord-272051-arz8r204	91	24	a	a	DT
cord-272051-arz8r204	91	25	consequence	consequence	NN
cord-272051-arz8r204	91	26	of	of	IN
cord-272051-arz8r204	91	27	the	the	DT
cord-272051-arz8r204	91	28	inhibition	inhibition	NN
cord-272051-arz8r204	91	29	on	on	IN
cord-272051-arz8r204	91	30	some	some	DT
cord-272051-arz8r204	91	31	step	step	NN
cord-272051-arz8r204	91	32	of	of	IN
cord-272051-arz8r204	91	33	the	the	DT
cord-272051-arz8r204	91	34	viral	viral	JJ
cord-272051-arz8r204	91	35	entry	entry	NN
cord-272051-arz8r204	91	36	involving	involve	VBG
cord-272051-arz8r204	91	37	the	the	DT
cord-272051-arz8r204	91	38	VSV	VSV	NNP
cord-272051-arz8r204	91	39	-	-	HYPH
cord-272051-arz8r204	91	40	G	G	NNP
cord-272051-arz8r204	91	41	envelope	envelope	NN
cord-272051-arz8r204	91	42	protein	protein	NN
cord-272051-arz8r204	91	43	.	.	.
cord-272051-arz8r204	92	1	To	to	TO
cord-272051-arz8r204	92	2	add	add	VB
cord-272051-arz8r204	92	3	relevance	relevance	NN
cord-272051-arz8r204	92	4	to	to	IN
cord-272051-arz8r204	92	5	our	-PRON-	PRP$
cord-272051-arz8r204	92	6	findings	finding	NNS
cord-272051-arz8r204	92	7	,	,	,
cord-272051-arz8r204	92	8	the	the	DT
cord-272051-arz8r204	92	9	possibility	possibility	NN
cord-272051-arz8r204	92	10	that	that	IN
cord-272051-arz8r204	92	11	the	the	DT
cord-272051-arz8r204	92	12	inhibitory	inhibitory	JJ
cord-272051-arz8r204	92	13	effect	effect	NN
cord-272051-arz8r204	92	14	of	of	IN
cord-272051-arz8r204	92	15	PIs	pi	NNS
cord-272051-arz8r204	92	16	applied	apply	VBN
cord-272051-arz8r204	92	17	also	also	RB
cord-272051-arz8r204	92	18	to	to	IN
cord-272051-arz8r204	92	19	alternative	alternative	JJ
cord-272051-arz8r204	92	20	virus	virus	NN
cord-272051-arz8r204	92	21	species	specie	NNS
cord-272051-arz8r204	92	22	infecting	infect	VBG
cord-272051-arz8r204	92	23	by	by	IN
cord-272051-arz8r204	92	24	pHdependent	pHdependent	NNP
cord-272051-arz8r204	92	25	fusion	fusion	NN
cord-272051-arz8r204	92	26	was	be	VBD
cord-272051-arz8r204	92	27	investigated	investigate	VBN
cord-272051-arz8r204	92	28	.	.	.
cord-272051-arz8r204	93	1	To	to	IN
cord-272051-arz8r204	93	2	this	this	DT
cord-272051-arz8r204	93	3	aim	aim	NN
cord-272051-arz8r204	93	4	,	,	,
cord-272051-arz8r204	93	5	the	the	DT
cord-272051-arz8r204	93	6	well	well	RB
cord-272051-arz8r204	93	7	characterized	characterize	VBN
cord-272051-arz8r204	93	8	influenza	influenza	NN
cord-272051-arz8r204	93	9	virus	virus	NN
cord-272051-arz8r204	93	10	/	/	SYM
cord-272051-arz8r204	93	11	MDCK	MDCK	NNP
cord-272051-arz8r204	93	12	cell	cell	NN
cord-272051-arz8r204	93	13	system	system	NN
cord-272051-arz8r204	93	14	was	be	VBD
cord-272051-arz8r204	93	15	considered	consider	VBN
cord-272051-arz8r204	93	16	.	.	.
cord-272051-arz8r204	94	1	MDCK	MDCK	NNP
cord-272051-arz8r204	94	2	cells	cell	NNS
cord-272051-arz8r204	94	3	were	be	VBD
cord-272051-arz8r204	94	4	treated	treat	VBN
cord-272051-arz8r204	94	5	overnight	overnight	RB
cord-272051-arz8r204	94	6	with	with	IN
cord-272051-arz8r204	94	7	different	different	JJ
cord-272051-arz8r204	94	8	PIs	pi	NNS
cord-272051-arz8r204	94	9	,	,	,
cord-272051-arz8r204	94	10	and	and	CC
cord-272051-arz8r204	94	11	then	then	RB
cord-272051-arz8r204	94	12	challenged	challenge	VBD
cord-272051-arz8r204	94	13	with	with	IN
cord-272051-arz8r204	94	14	m.o.i	m.o.i	NN
cord-272051-arz8r204	94	15	.	.	.
cord-272051-arz8r204	94	16	0.1	0.1	CD
cord-272051-arz8r204	94	17	and	and	CC
cord-272051-arz8r204	94	18	0.5	0.5	CD
cord-272051-arz8r204	94	19	of	of	IN
cord-272051-arz8r204	94	20	the	the	DT
cord-272051-arz8r204	94	21	PR8	PR8	NNP
cord-272051-arz8r204	94	22	influenza	influenza	NN
cord-272051-arz8r204	94	23	virus	virus	NN
cord-272051-arz8r204	94	24	.	.	.
cord-272051-arz8r204	95	1	After	after	IN
cord-272051-arz8r204	95	2	challenge	challenge	NN
cord-272051-arz8r204	95	3	,	,	,
cord-272051-arz8r204	95	4	the	the	DT
cord-272051-arz8r204	95	5	cells	cell	NNS
cord-272051-arz8r204	95	6	were	be	VBD
cord-272051-arz8r204	95	7	extensively	extensively	RB
cord-272051-arz8r204	95	8	washed	wash	VBN
cord-272051-arz8r204	95	9	,	,	,
cord-272051-arz8r204	95	10	and	and	CC
cord-272051-arz8r204	95	11	reseeded	reseed	VBN
cord-272051-arz8r204	95	12	in	in	IN
cord-272051-arz8r204	95	13	medium	medium	NN
cord-272051-arz8r204	95	14	without	without	IN
cord-272051-arz8r204	95	15	serum	serum	NN
cord-272051-arz8r204	95	16	in	in	IN
cord-272051-arz8r204	95	17	the	the	DT
cord-272051-arz8r204	95	18	presence	presence	NN
cord-272051-arz8r204	95	19	of	of	IN
cord-272051-arz8r204	95	20	both	both	DT
cord-272051-arz8r204	95	21	PIs	pi	NNS
cord-272051-arz8r204	95	22	and	and	CC
cord-272051-arz8r204	95	23	tosylamido-2-phenil	tosylamido-2-phenil	NNP
cord-272051-arz8r204	95	24	ethyl	ethyl	NN
cord-272051-arz8r204	95	25	chloromethyl	chloromethyl	NN
cord-272051-arz8r204	95	26	ketone	ketone	NN
cord-272051-arz8r204	95	27	(	(	-LRB-
cord-272051-arz8r204	95	28	TPCK)-treated	tpck)-treate	VBN
cord-272051-arz8r204	95	29	trypsin	trypsin	NN
cord-272051-arz8r204	95	30	.	.	.
cord-272051-arz8r204	96	1	Twenty	twenty	CD
cord-272051-arz8r204	96	2	-	-	HYPH
cord-272051-arz8r204	96	3	four	four	CD
cord-272051-arz8r204	96	4	h	h	NN
cord-272051-arz8r204	96	5	later	later	RB
cord-272051-arz8r204	96	6	(	(	-LRB-
cord-272051-arz8r204	96	7	i.e.	i.e.	FW
cord-272051-arz8r204	96	8	,	,	,
cord-272051-arz8r204	96	9	the	the	DT
cord-272051-arz8r204	96	10	expected	expect	VBN
cord-272051-arz8r204	96	11	time	time	NN
cord-272051-arz8r204	96	12	for	for	IN
cord-272051-arz8r204	96	13	the	the	DT
cord-272051-arz8r204	96	14	completion	completion	NN
cord-272051-arz8r204	96	15	of	of	IN
cord-272051-arz8r204	96	16	the	the	DT
cord-272051-arz8r204	96	17	replication	replication	NN
cord-272051-arz8r204	96	18	cycle	cycle	NN
cord-272051-arz8r204	96	19	of	of	IN
cord-272051-arz8r204	96	20	influenza	influenza	NN
cord-272051-arz8r204	96	21	virus	virus	NN
cord-272051-arz8r204	96	22	)	)	-RRB-
cord-272051-arz8r204	97	1	(	(	-LRB-
cord-272051-arz8r204	97	2	Sidorenko	Sidorenko	NNP
cord-272051-arz8r204	97	3	and	and	CC
cord-272051-arz8r204	97	4	Reichl	Reichl	NNP
cord-272051-arz8r204	97	5	,	,	,
cord-272051-arz8r204	97	6	2004	2004	CD
cord-272051-arz8r204	97	7	;	;	:
cord-272051-arz8r204	97	8	Smith	Smith	NNP
cord-272051-arz8r204	97	9	and	and	CC
cord-272051-arz8r204	97	10	Ribeiro	Ribeiro	NNP
cord-272051-arz8r204	97	11	,	,	,
cord-272051-arz8r204	97	12	2010	2010	CD
cord-272051-arz8r204	97	13	)	)	-RRB-
cord-272051-arz8r204	97	14	,	,	,
cord-272051-arz8r204	97	15	the	the	DT
cord-272051-arz8r204	97	16	supernatants	supernatant	NNS
cord-272051-arz8r204	97	17	were	be	VBD
cord-272051-arz8r204	97	18	harvested	harvest	VBN
cord-272051-arz8r204	97	19	and	and	CC
cord-272051-arz8r204	97	20	titrated	titrate	VBN
cord-272051-arz8r204	97	21	for	for	IN
cord-272051-arz8r204	97	22	the	the	DT
cord-272051-arz8r204	97	23	contents	content	NNS
cord-272051-arz8r204	97	24	of	of	IN
cord-272051-arz8r204	97	25	infectious	infectious	JJ
cord-272051-arz8r204	97	26	particles	particle	NNS
cord-272051-arz8r204	97	27	.	.	.
cord-272051-arz8r204	98	1	A	a	DT
cord-272051-arz8r204	98	2	strong	strong	JJ
cord-272051-arz8r204	98	3	inhibition	inhibition	NN
cord-272051-arz8r204	98	4	of	of	IN
cord-272051-arz8r204	98	5	the	the	DT
cord-272051-arz8r204	98	6	replication	replication	NN
cord-272051-arz8r204	98	7	of	of	IN
cord-272051-arz8r204	98	8	influenza	influenza	NN
cord-272051-arz8r204	98	9	virus	virus	NN
cord-272051-arz8r204	98	10	(	(	-LRB-
cord-272051-arz8r204	98	11	up	up	IN
cord-272051-arz8r204	98	12	to	to	TO
cord-272051-arz8r204	98	13	4	4	CD
cord-272051-arz8r204	98	14	logs	log	NNS
cord-272051-arz8r204	98	15	at	at	IN
cord-272051-arz8r204	98	16	the	the	DT
cord-272051-arz8r204	98	17	lower	low	JJR
cord-272051-arz8r204	98	18	m.o.i	m.o.i	NN
cord-272051-arz8r204	98	19	.	.	.
cord-272051-arz8r204	98	20	)	)	-RRB-
cord-272051-arz8r204	98	21	has	have	VBZ
cord-272051-arz8r204	98	22	been	be	VBN
cord-272051-arz8r204	98	23	detected	detect	VBN
cord-272051-arz8r204	98	24	with	with	IN
cord-272051-arz8r204	98	25	10	10	CD
cord-272051-arz8r204	98	26	μM	μm	CD
cord-272051-arz8r204	98	27	saquinavir	saquinavir	NNS
cord-272051-arz8r204	98	28	and	and	CC
cord-272051-arz8r204	98	29	5	5	CD
cord-272051-arz8r204	98	30	μM	μm	CD
cord-272051-arz8r204	98	31	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	99	1	(	(	-LRB-
cord-272051-arz8r204	99	2	Fig	Fig	NNP
cord-272051-arz8r204	99	3	.	.	.
cord-272051-arz8r204	99	4	3A	3A	NNP
cord-272051-arz8r204	99	5	)	)	-RRB-
cord-272051-arz8r204	99	6	.	.	.
cord-272051-arz8r204	100	1	Ritonavir	Ritonavir	NNP
cord-272051-arz8r204	100	2	inhibited	inhibit	VBD
cord-272051-arz8r204	100	3	the	the	DT
cord-272051-arz8r204	100	4	viral	viral	JJ
cord-272051-arz8r204	100	5	replication	replication	NN
cord-272051-arz8r204	100	6	less	less	RBR
cord-272051-arz8r204	100	7	efficiently	efficiently	RB
cord-272051-arz8r204	100	8	(	(	-LRB-
cord-272051-arz8r204	100	9	Fig	Fig	NNP
cord-272051-arz8r204	100	10	.	.	.
cord-272051-arz8r204	100	11	3A	3A	NNP
cord-272051-arz8r204	100	12	)	)	-RRB-
cord-272051-arz8r204	100	13	,	,	,
cord-272051-arz8r204	100	14	while	while	IN
cord-272051-arz8r204	100	15	indinavir	indinavir	NNP
cord-272051-arz8r204	100	16	,	,	,
cord-272051-arz8r204	100	17	amprenavir	amprenavir	NNP
cord-272051-arz8r204	100	18	and	and	CC
cord-272051-arz8r204	100	19	atazanavir	atazanavir	NNS
cord-272051-arz8r204	100	20	appeared	appear	VBD
cord-272051-arz8r204	100	21	ineffective	ineffective	JJ
cord-272051-arz8r204	100	22	(	(	-LRB-
cord-272051-arz8r204	100	23	not	not	RB
cord-272051-arz8r204	100	24	shown	show	VBN
cord-272051-arz8r204	100	25	)	)	-RRB-
cord-272051-arz8r204	100	26	.	.	.
cord-272051-arz8r204	101	1	In	in	IN
cord-272051-arz8r204	101	2	the	the	DT
cord-272051-arz8r204	101	3	interpretation	interpretation	NN
cord-272051-arz8r204	101	4	of	of	IN
cord-272051-arz8r204	101	5	these	these	DT
cord-272051-arz8r204	101	6	data	datum	NNS
cord-272051-arz8r204	101	7	,	,	,
cord-272051-arz8r204	101	8	it	-PRON-	PRP
cord-272051-arz8r204	101	9	should	should	MD
cord-272051-arz8r204	101	10	be	be	VB
cord-272051-arz8r204	101	11	emphasized	emphasize	VBN
cord-272051-arz8r204	101	12	that	that	IN
cord-272051-arz8r204	101	13	the	the	DT
cord-272051-arz8r204	101	14	inhibitory	inhibitory	JJ
cord-272051-arz8r204	101	15	effect	effect	NN
cord-272051-arz8r204	101	16	of	of	IN
cord-272051-arz8r204	101	17	PIs	pi	NNS
cord-272051-arz8r204	101	18	can	can	MD
cord-272051-arz8r204	101	19	not	not	RB
cord-272051-arz8r204	101	20	be	be	VB
cord-272051-arz8r204	101	21	a	a	DT
cord-272051-arz8r204	101	22	consequence	consequence	NN
cord-272051-arz8r204	101	23	of	of	IN
cord-272051-arz8r204	101	24	a	a	DT
cord-272051-arz8r204	101	25	PI	pi	NN
cord-272051-arz8r204	101	26	-	-	HYPH
cord-272051-arz8r204	101	27	induced	induce	VBN
cord-272051-arz8r204	101	28	impairment	impairment	NN
cord-272051-arz8r204	101	29	of	of	IN
cord-272051-arz8r204	101	30	the	the	DT
cord-272051-arz8r204	101	31	activation	activation	NN
cord-272051-arz8r204	101	32	of	of	IN
cord-272051-arz8r204	101	33	the	the	DT
cord-272051-arz8r204	101	34	hemagglutinin	hemagglutinin	NN
cord-272051-arz8r204	101	35	envelope	envelope	NN
cord-272051-arz8r204	101	36	protein	protein	NN
cord-272051-arz8r204	101	37	(	(	-LRB-
cord-272051-arz8r204	101	38	HA	HA	NNP
cord-272051-arz8r204	101	39	)	)	-RRB-
cord-272051-arz8r204	101	40	of	of	IN
cord-272051-arz8r204	101	41	the	the	DT
cord-272051-arz8r204	101	42	influenza	influenza	NN
cord-272051-arz8r204	101	43	virus	virus	NN
cord-272051-arz8r204	101	44	,	,	,
cord-272051-arz8r204	101	45	which	which	WDT
cord-272051-arz8r204	101	46	is	be	VBZ
cord-272051-arz8r204	101	47	a	a	DT
cord-272051-arz8r204	101	48	step	step	NN
cord-272051-arz8r204	101	49	required	require	VBN
cord-272051-arz8r204	101	50	for	for	IN
cord-272051-arz8r204	101	51	productive	productive	JJ
cord-272051-arz8r204	101	52	infection	infection	NN
cord-272051-arz8r204	101	53	(	(	-LRB-
cord-272051-arz8r204	101	54	Steinhauer	Steinhauer	NNP
cord-272051-arz8r204	101	55	,	,	,
cord-272051-arz8r204	101	56	1999	1999	CD
cord-272051-arz8r204	101	57	)	)	-RRB-
cord-272051-arz8r204	101	58	.	.	.
cord-272051-arz8r204	102	1	In	in	IN
cord-272051-arz8r204	102	2	fact	fact	NN
cord-272051-arz8r204	102	3	,	,	,
cord-272051-arz8r204	102	4	influenza	influenza	NN
cord-272051-arz8r204	102	5	virus	virus	NN
cord-272051-arz8r204	102	6	preparations	preparation	NNS
cord-272051-arz8r204	102	7	used	use	VBN
cord-272051-arz8r204	102	8	for	for	IN
cord-272051-arz8r204	102	9	challenges	challenge	NNS
cord-272051-arz8r204	102	10	were	be	VBD
cord-272051-arz8r204	102	11	exclusively	exclusively	RB
cord-272051-arz8r204	102	12	recovered	recover	VBN
cord-272051-arz8r204	102	13	from	from	IN
cord-272051-arz8r204	102	14	the	the	DT
cord-272051-arz8r204	102	15	allantoic	allantoic	NNP
cord-272051-arz8r204	102	16	fluid	fluid	NN
cord-272051-arz8r204	102	17	of	of	IN
cord-272051-arz8r204	102	18	embryonated	embryonate	VBN
cord-272051-arz8r204	102	19	chicken	chicken	NN
cord-272051-arz8r204	102	20	eggs	egg	NNS
cord-272051-arz8r204	102	21	,	,	,
cord-272051-arz8r204	102	22	where	where	WRB
cord-272051-arz8r204	102	23	HA	HA	NNP
cord-272051-arz8r204	102	24	is	be	VBZ
cord-272051-arz8r204	102	25	cleaved	cleave	VBN
cord-272051-arz8r204	102	26	by	by	IN
cord-272051-arz8r204	102	27	egg	egg	NN
cord-272051-arz8r204	102	28	proteases	protease	NNS
cord-272051-arz8r204	102	29	.	.	.
cord-272051-arz8r204	103	1	Consistently	consistently	RB
cord-272051-arz8r204	103	2	,	,	,
cord-272051-arz8r204	103	3	TPCK	TPCK	NNP
cord-272051-arz8r204	103	4	-	-	HYPH
cord-272051-arz8r204	103	5	trypsin	trypsin	NN
cord-272051-arz8r204	103	6	did	do	VBD
cord-272051-arz8r204	103	7	not	not	RB
cord-272051-arz8r204	103	8	influence	influence	VB
cord-272051-arz8r204	103	9	the	the	DT
cord-272051-arz8r204	103	10	infectivity	infectivity	NN
cord-272051-arz8r204	103	11	of	of	IN
cord-272051-arz8r204	103	12	the	the	DT
cord-272051-arz8r204	103	13	virus	virus	NN
cord-272051-arz8r204	103	14	preparations	preparation	NNS
cord-272051-arz8r204	103	15	in	in	IN
cord-272051-arz8r204	103	16	single	single	JJ
cord-272051-arz8r204	103	17	cycle	cycle	NN
cord-272051-arz8r204	103	18	replication	replication	NN
cord-272051-arz8r204	103	19	assay	assay	NN
cord-272051-arz8r204	103	20	(	(	-LRB-
cord-272051-arz8r204	103	21	not	not	RB
cord-272051-arz8r204	103	22	shown	show	VBN
cord-272051-arz8r204	103	23	)	)	-RRB-
cord-272051-arz8r204	103	24	.	.	.
cord-272051-arz8r204	104	1	The	the	DT
cord-272051-arz8r204	104	2	cell	cell	NN
cord-272051-arz8r204	104	3	cytotoxicity	cytotoxicity	NN
cord-272051-arz8r204	104	4	of	of	IN
cord-272051-arz8r204	104	5	PIs	pi	NNS
cord-272051-arz8r204	104	6	active	active	JJ
cord-272051-arz8r204	104	7	against	against	IN
cord-272051-arz8r204	104	8	influenza	influenza	NN
cord-272051-arz8r204	104	9	virus	virus	NN
cord-272051-arz8r204	104	10	was	be	VBD
cord-272051-arz8r204	104	11	then	then	RB
cord-272051-arz8r204	104	12	evaluated	evaluate	VBN
cord-272051-arz8r204	104	13	in	in	IN
cord-272051-arz8r204	104	14	MDCK	MDCK	NNP
cord-272051-arz8r204	104	15	cells	cell	NNS
cord-272051-arz8r204	104	16	similarly	similarly	RB
cord-272051-arz8r204	104	17	to	to	IN
cord-272051-arz8r204	104	18	what	what	WP
cord-272051-arz8r204	104	19	above	above	IN
cord-272051-arz8r204	104	20	described	describe	VBN
cord-272051-arz8r204	104	21	for	for	IN
cord-272051-arz8r204	104	22	HeLa	HeLa	NNP
cord-272051-arz8r204	104	23	cells	cell	NNS
cord-272051-arz8r204	104	24	(	(	-LRB-
cord-272051-arz8r204	104	25	Fig	fig	NN
cord-272051-arz8r204	104	26	.	.	.
cord-272051-arz8r204	104	27	3B	3B	NNP
cord-272051-arz8r204	104	28	)	)	-RRB-
cord-272051-arz8r204	104	29	.	.	.
cord-272051-arz8r204	105	1	Block	block	NN
cord-272051-arz8r204	105	2	of	of	IN
cord-272051-arz8r204	105	3	cell	cell	NN
cord-272051-arz8r204	105	4	duplication	duplication	NN
cord-272051-arz8r204	105	5	in	in	IN
cord-272051-arz8r204	105	6	the	the	DT
cord-272051-arz8r204	105	7	presence	presence	NN
cord-272051-arz8r204	105	8	of	of	IN
cord-272051-arz8r204	105	9	cell	cell	NN
cord-272051-arz8r204	105	10	mortality	mortality	NN
cord-272051-arz8r204	105	11	over	over	IN
cord-272051-arz8r204	105	12	20	20	CD
cord-272051-arz8r204	105	13	%	%	NN
cord-272051-arz8r204	105	14	has	have	VBZ
cord-272051-arz8r204	105	15	been	be	VBN
cord-272051-arz8r204	105	16	detected	detect	VBN
cord-272051-arz8r204	105	17	with	with	IN
cord-272051-arz8r204	105	18	100	100	CD
cord-272051-arz8r204	105	19	μM	μM	NNP
cord-272051-arz8r204	105	20	ritonavir	ritonavir	NNP
cord-272051-arz8r204	105	21	and	and	CC
cord-272051-arz8r204	105	22	saquinavir	saquinavir	NNP
cord-272051-arz8r204	105	23	,	,	,
cord-272051-arz8r204	105	24	and	and	CC
cord-272051-arz8r204	105	25	with	with	IN
cord-272051-arz8r204	105	26	50	50	CD
cord-272051-arz8r204	105	27	μM	μm	CD
cord-272051-arz8r204	105	28	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	105	29	.	.	.
cord-272051-arz8r204	106	1	The	the	DT
cord-272051-arz8r204	106	2	therapeutic	therapeutic	JJ
cord-272051-arz8r204	106	3	indexes	index	NNS
cord-272051-arz8r204	106	4	appeared	appear	VBD
cord-272051-arz8r204	106	5	higher	high	JJR
cord-272051-arz8r204	106	6	than	than	IN
cord-272051-arz8r204	106	7	15	15	CD
cord-272051-arz8r204	106	8	for	for	IN
cord-272051-arz8r204	106	9	both	both	DT
cord-272051-arz8r204	106	10	saquinavir	saquinavir	NNS
cord-272051-arz8r204	106	11	and	and	CC
cord-272051-arz8r204	106	12	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	106	13	.	.	.
cord-272051-arz8r204	107	1	The	the	DT
cord-272051-arz8r204	107	2	assay	assay	NN
cord-272051-arz8r204	107	3	gave	give	VBD
cord-272051-arz8r204	107	4	similar	similar	JJ
cord-272051-arz8r204	107	5	results	result	NNS
cord-272051-arz8r204	107	6	when	when	WRB
cord-272051-arz8r204	107	7	the	the	DT
cord-272051-arz8r204	107	8	cells	cell	NNS
cord-272051-arz8r204	107	9	were	be	VBD
cord-272051-arz8r204	107	10	analyzed	analyze	VBN
cord-272051-arz8r204	107	11	24	24	CD
cord-272051-arz8r204	107	12	h	h	NN
cord-272051-arz8r204	107	13	after	after	IN
cord-272051-arz8r204	107	14	CFSE	CFSE	NNP
cord-272051-arz8r204	107	15	labeling	labeling	NN
cord-272051-arz8r204	107	16	(	(	-LRB-
cord-272051-arz8r204	107	17	not	not	RB
cord-272051-arz8r204	107	18	shown	show	VBN
cord-272051-arz8r204	107	19	)	)	-RRB-
cord-272051-arz8r204	107	20	.	.	.
cord-272051-arz8r204	108	1	Taken	take	VBN
cord-272051-arz8r204	108	2	together	together	RB
cord-272051-arz8r204	108	3	,	,	,
cord-272051-arz8r204	108	4	these	these	DT
cord-272051-arz8r204	108	5	data	datum	NNS
cord-272051-arz8r204	108	6	suggest	suggest	VBP
cord-272051-arz8r204	108	7	that	that	IN
cord-272051-arz8r204	108	8	PIs	pi	NNS
cord-272051-arz8r204	108	9	could	could	MD
cord-272051-arz8r204	108	10	target	target	VB
cord-272051-arz8r204	108	11	the	the	DT
cord-272051-arz8r204	108	12	replication	replication	NN
cord-272051-arz8r204	108	13	of	of	IN
cord-272051-arz8r204	108	14	diverse	diverse	JJ
cord-272051-arz8r204	108	15	enveloped	envelop	VBN
cord-272051-arz8r204	108	16	viruses	virus	NNS
cord-272051-arz8r204	108	17	infecting	infect	VBG
cord-272051-arz8r204	108	18	by	by	IN
cord-272051-arz8r204	108	19	a	a	DT
cord-272051-arz8r204	108	20	pH	ph	JJ
cord-272051-arz8r204	108	21	-	-	HYPH
cord-272051-arz8r204	108	22	dependent	dependent	JJ
cord-272051-arz8r204	108	23	endocytic	endocytic	JJ
cord-272051-arz8r204	108	24	pathway	pathway	NN
cord-272051-arz8r204	108	25	.	.	.
cord-272051-arz8r204	109	1	Next	next	RB
cord-272051-arz8r204	109	2	,	,	,
cord-272051-arz8r204	109	3	it	-PRON-	PRP
cord-272051-arz8r204	109	4	was	be	VBD
cord-272051-arz8r204	109	5	investigated	investigate	VBN
cord-272051-arz8r204	109	6	whether	whether	IN
cord-272051-arz8r204	109	7	the	the	DT
cord-272051-arz8r204	109	8	PIs	pi	NNS
cord-272051-arz8r204	109	9	most	most	RBS
cord-272051-arz8r204	109	10	effective	effective	JJ
cord-272051-arz8r204	109	11	against	against	IN
cord-272051-arz8r204	109	12	VSV	VSV	NNP
cord-272051-arz8r204	109	13	and	and	CC
cord-272051-arz8r204	109	14	influenza	influenza	NN
cord-272051-arz8r204	109	15	virus	virus	NN
cord-272051-arz8r204	109	16	replication	replication	NN
cord-272051-arz8r204	109	17	counteract	counteract	VBP
cord-272051-arz8r204	109	18	also	also	RB
cord-272051-arz8r204	109	19	the	the	DT
cord-272051-arz8r204	109	20	replication	replication	NN
cord-272051-arz8r204	109	21	of	of	IN
cord-272051-arz8r204	109	22	viruses	virus	NNS
cord-272051-arz8r204	109	23	infecting	infect	VBG
cord-272051-arz8r204	109	24	by	by	IN
cord-272051-arz8r204	109	25	a	a	DT
cord-272051-arz8r204	109	26	pH	ph	JJ
cord-272051-arz8r204	109	27	-	-	JJ
cord-272051-arz8r204	109	28	independent	independent	JJ
cord-272051-arz8r204	109	29	mechanism	mechanism	NN
cord-272051-arz8r204	109	30	.	.	.
cord-272051-arz8r204	110	1	As	as	IN
cord-272051-arz8r204	110	2	a	a	DT
cord-272051-arz8r204	110	3	proof	proof	NN
cord-272051-arz8r204	110	4	of	of	IN
cord-272051-arz8r204	110	5	principle	principle	NN
cord-272051-arz8r204	110	6	,	,	,
cord-272051-arz8r204	110	7	the	the	DT
cord-272051-arz8r204	110	8	PIs	pi	NNS
cord-272051-arz8r204	110	9	were	be	VBD
cord-272051-arz8r204	110	10	assayed	assay	VBN
cord-272051-arz8r204	110	11	against	against	IN
cord-272051-arz8r204	110	12	the	the	DT
cord-272051-arz8r204	110	13	replication	replication	NN
cord-272051-arz8r204	110	14	of	of	IN
cord-272051-arz8r204	110	15	Newcastle	Newcastle	NNP
cord-272051-arz8r204	110	16	Disease	Disease	NNP
cord-272051-arz8r204	110	17	virus	virus	NN
cord-272051-arz8r204	110	18	(	(	-LRB-
cord-272051-arz8r204	110	19	NDV	NDV	NNP
cord-272051-arz8r204	110	20	)	)	-RRB-
cord-272051-arz8r204	110	21	,	,	,
cord-272051-arz8r204	110	22	i.e.	i.e.	FW
cord-272051-arz8r204	110	23	,	,	,
cord-272051-arz8r204	110	24	a	a	DT
cord-272051-arz8r204	110	25	Paramixovirus	Paramixovirus	NNP
cord-272051-arz8r204	110	26	infecting	infect	VBG
cord-272051-arz8r204	110	27	upon	upon	IN
cord-272051-arz8r204	110	28	fusion	fusion	NN
cord-272051-arz8r204	110	29	at	at	IN
cord-272051-arz8r204	110	30	the	the	DT
cord-272051-arz8r204	110	31	cell	cell	NN
cord-272051-arz8r204	110	32	surface	surface	NN
cord-272051-arz8r204	110	33	.	.	.
cord-272051-arz8r204	111	1	MDCK	MDCK	NNP
cord-272051-arz8r204	111	2	cells	cell	NNS
cord-272051-arz8r204	111	3	were	be	VBD
cord-272051-arz8r204	111	4	pre	pre	JJ
cord-272051-arz8r204	111	5	-	-	VBN
cord-272051-arz8r204	111	6	treated	treat	VBN
cord-272051-arz8r204	111	7	with	with	IN
cord-272051-arz8r204	111	8	2.5	2.5	CD
cord-272051-arz8r204	111	9	to	to	TO
cord-272051-arz8r204	111	10	10	10	CD
cord-272051-arz8r204	111	11	μM	μm	CD
cord-272051-arz8r204	111	12	saquinavir	saquinavir	NNS
cord-272051-arz8r204	111	13	or	or	CC
cord-272051-arz8r204	111	14	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	111	15	,	,	,
cord-272051-arz8r204	111	16	and	and	CC
cord-272051-arz8r204	111	17	then	then	RB
cord-272051-arz8r204	111	18	infected	infect	VBN
cord-272051-arz8r204	111	19	with	with	IN
cord-272051-arz8r204	111	20	2-fold	2-fold	DT
cord-272051-arz8r204	111	21	decreasing	decrease	VBG
cord-272051-arz8r204	111	22	amounts	amount	NNS
cord-272051-arz8r204	111	23	of	of	IN
cord-272051-arz8r204	111	24	NDV	NDV	NNP
cord-272051-arz8r204	111	25	starting	start	VBG
cord-272051-arz8r204	111	26	to	to	IN
cord-272051-arz8r204	111	27	m.o.i	m.o.i	NNP
cord-272051-arz8r204	111	28	.	.	NNP
cord-272051-arz8r204	111	29	1	1	CD
cord-272051-arz8r204	111	30	.	.	.
cord-272051-arz8r204	112	1	The	the	DT
cord-272051-arz8r204	112	2	cytopathic	cytopathic	JJ
cord-272051-arz8r204	112	3	effect	effect	NN
cord-272051-arz8r204	112	4	was	be	VBD
cord-272051-arz8r204	112	5	monitored	monitor	VBN
cord-272051-arz8r204	112	6	48	48	CD
cord-272051-arz8r204	112	7	h	h	NN
cord-272051-arz8r204	112	8	post	post	NN
cord-272051-arz8r204	112	9	challenge	challenge	NN
cord-272051-arz8r204	112	10	.	.	.
cord-272051-arz8r204	113	1	No	no	DT
cord-272051-arz8r204	113	2	significant	significant	JJ
cord-272051-arz8r204	113	3	reductions	reduction	NNS
cord-272051-arz8r204	113	4	in	in	IN
cord-272051-arz8r204	113	5	the	the	DT
cord-272051-arz8r204	113	6	NDV	ndv	JJ
cord-272051-arz8r204	113	7	infectivity	infectivity	NN
cord-272051-arz8r204	113	8	have	have	VBP
cord-272051-arz8r204	113	9	been	be	VBN
cord-272051-arz8r204	113	10	noticed	notice	VBN
cord-272051-arz8r204	113	11	in	in	IN
cord-272051-arz8r204	113	12	PI	pi	NN
cord-272051-arz8r204	113	13	-	-	HYPH
cord-272051-arz8r204	113	14	treated	treat	VBN
cord-272051-arz8r204	113	15	as	as	IN
cord-272051-arz8r204	113	16	compared	compare	VBN
cord-272051-arz8r204	113	17	to	to	TO
cord-272051-arz8r204	113	18	control	control	VB
cord-272051-arz8r204	113	19	cell	cell	NN
cord-272051-arz8r204	113	20	cultures	culture	NNS
cord-272051-arz8r204	113	21	(	(	-LRB-
cord-272051-arz8r204	113	22	Fig	Fig	NNP
cord-272051-arz8r204	113	23	.	.	NNP
cord-272051-arz8r204	113	24	4	4	CD
cord-272051-arz8r204	113	25	)	)	-RRB-
cord-272051-arz8r204	113	26	.	.	.
cord-272051-arz8r204	114	1	These	these	DT
cord-272051-arz8r204	114	2	results	result	NNS
cord-272051-arz8r204	114	3	indicate	indicate	VBP
cord-272051-arz8r204	114	4	that	that	IN
cord-272051-arz8r204	114	5	PIs	pi	NNS
cord-272051-arz8r204	114	6	do	do	VBP
cord-272051-arz8r204	114	7	not	not	RB
cord-272051-arz8r204	114	8	affect	affect	VB
cord-272051-arz8r204	114	9	the	the	DT
cord-272051-arz8r204	114	10	replication	replication	NN
cord-272051-arz8r204	114	11	of	of	IN
cord-272051-arz8r204	114	12	viruses	virus	NNS
cord-272051-arz8r204	114	13	entering	enter	VBG
cord-272051-arz8r204	114	14	by	by	IN
cord-272051-arz8r204	114	15	a	a	DT
cord-272051-arz8r204	114	16	pH	ph	JJ
cord-272051-arz8r204	114	17	-	-	JJ
cord-272051-arz8r204	114	18	independent	independent	JJ
cord-272051-arz8r204	114	19	way	way	NN
cord-272051-arz8r204	114	20	.	.	.
cord-272051-arz8r204	115	1	The	the	DT
cord-272051-arz8r204	115	2	inhibitory	inhibitory	JJ
cord-272051-arz8r204	115	3	effect	effect	NN
cord-272051-arz8r204	115	4	is	be	VBZ
cord-272051-arz8r204	115	5	operative	operative	JJ
cord-272051-arz8r204	115	6	when	when	WRB
cord-272051-arz8r204	115	7	PIs	pi	NNS
cord-272051-arz8r204	115	8	are	be	VBP
cord-272051-arz8r204	115	9	co	co	VBN
cord-272051-arz8r204	115	10	-	-	VBN
cord-272051-arz8r204	115	11	administered	administer	VBN
cord-272051-arz8r204	116	1	with	with	IN
cord-272051-arz8r204	116	2	the	the	DT
cord-272051-arz8r204	116	3	infecting	infect	VBG
cord-272051-arz8r204	116	4	virus	virus	NN
cord-272051-arz8r204	116	5	To	to	TO
cord-272051-arz8r204	116	6	identify	identify	VB
cord-272051-arz8r204	116	7	the	the	DT
cord-272051-arz8r204	116	8	virus	virus	NN
cord-272051-arz8r204	116	9	replication	replication	NN
cord-272051-arz8r204	116	10	step	step	NN
cord-272051-arz8r204	116	11	targeted	target	VBN
cord-272051-arz8r204	116	12	by	by	IN
cord-272051-arz8r204	116	13	PIs	pi	NNS
cord-272051-arz8r204	116	14	,	,	,
cord-272051-arz8r204	116	15	the	the	DT
cord-272051-arz8r204	116	16	effects	effect	NNS
cord-272051-arz8r204	116	17	of	of	IN
cord-272051-arz8r204	116	18	PIs	pi	NNS
cord-272051-arz8r204	116	19	added	add	VBD
cord-272051-arz8r204	116	20	before	before	IN
cord-272051-arz8r204	116	21	and/or	and/or	CC
cord-272051-arz8r204	116	22	after	after	IN
cord-272051-arz8r204	116	23	viral	viral	JJ
cord-272051-arz8r204	116	24	challenge	challenge	NN
cord-272051-arz8r204	116	25	were	be	VBD
cord-272051-arz8r204	116	26	evaluated	evaluate	VBN
cord-272051-arz8r204	116	27	.	.	.
cord-272051-arz8r204	117	1	The	the	DT
cord-272051-arz8r204	117	2	assays	assay	NNS
cord-272051-arz8r204	117	3	were	be	VBD
cord-272051-arz8r204	117	4	carried	carry	VBN
cord-272051-arz8r204	117	5	out	out	RP
cord-272051-arz8r204	117	6	using	use	VBG
cord-272051-arz8r204	117	7	both	both	DT
cord-272051-arz8r204	117	8	HeLa	HeLa	NNP
cord-272051-arz8r204	117	9	/	/	SYM
cord-272051-arz8r204	117	10	VSV	VSV	NNP
cord-272051-arz8r204	117	11	and	and	CC
cord-272051-arz8r204	117	12	MDCK	MDCK	NNP
cord-272051-arz8r204	117	13	/	/	SYM
cord-272051-arz8r204	117	14	influenza	influenza	NN
cord-272051-arz8r204	117	15	virus	virus	NN
cord-272051-arz8r204	117	16	systems	system	NNS
cord-272051-arz8r204	117	17	.	.	.
cord-272051-arz8r204	118	1	In	in	IN
cord-272051-arz8r204	118	2	a	a	DT
cord-272051-arz8r204	118	3	first	first	JJ
cord-272051-arz8r204	118	4	set	set	NN
cord-272051-arz8r204	118	5	of	of	IN
cord-272051-arz8r204	118	6	experiments	experiment	NNS
cord-272051-arz8r204	118	7	,	,	,
cord-272051-arz8r204	118	8	the	the	DT
cord-272051-arz8r204	118	9	PI	PI	NNP
cord-272051-arz8r204	118	10	treatment	treatment	NN
cord-272051-arz8r204	118	11	was	be	VBD
cord-272051-arz8r204	118	12	discontinued	discontinue	VBN
cord-272051-arz8r204	118	13	just	just	RB
cord-272051-arz8r204	118	14	before	before	IN
cord-272051-arz8r204	118	15	the	the	DT
cord-272051-arz8r204	118	16	virus	virus	NN
cord-272051-arz8r204	118	17	challenge	challenge	NN
cord-272051-arz8r204	118	18	.	.	.
cord-272051-arz8r204	119	1	Then	then	RB
cord-272051-arz8r204	119	2	,	,	,
cord-272051-arz8r204	119	3	the	the	DT
cord-272051-arz8r204	119	4	cells	cell	NNS
cord-272051-arz8r204	119	5	were	be	VBD
cord-272051-arz8r204	119	6	infected	infect	VBN
cord-272051-arz8r204	119	7	with	with	IN
cord-272051-arz8r204	119	8	VSV	VSV	NNP
cord-272051-arz8r204	119	9	or	or	CC
cord-272051-arz8r204	119	10	influenza	influenza	NN
cord-272051-arz8r204	119	11	virus	virus	NN
cord-272051-arz8r204	119	12	at	at	IN
cord-272051-arz8r204	119	13	m.o.i	m.o.i	NNP
cord-272051-arz8r204	119	14	.	.	NNP
cord-272051-arz8r204	119	15	of	of	IN
cord-272051-arz8r204	119	16	0.2	0.2	CD
cord-272051-arz8r204	119	17	and	and	CC
cord-272051-arz8r204	119	18	0.5	0.5	CD
cord-272051-arz8r204	119	19	,	,	,
cord-272051-arz8r204	119	20	respectively	respectively	RB
cord-272051-arz8r204	119	21	.	.	.
cord-272051-arz8r204	120	1	After	after	IN
cord-272051-arz8r204	120	2	1	1	CD
cord-272051-arz8r204	120	3	h	h	NN
cord-272051-arz8r204	120	4	of	of	IN
cord-272051-arz8r204	120	5	adsorption	adsorption	NN
cord-272051-arz8r204	120	6	,	,	,
cord-272051-arz8r204	120	7	the	the	DT
cord-272051-arz8r204	120	8	cells	cell	NNS
cord-272051-arz8r204	120	9	were	be	VBD
cord-272051-arz8r204	120	10	extensively	extensively	RB
cord-272051-arz8r204	120	11	washed	wash	VBN
cord-272051-arz8r204	120	12	and	and	CC
cord-272051-arz8r204	120	13	refed	refe	VBN
cord-272051-arz8r204	120	14	in	in	IN
cord-272051-arz8r204	120	15	the	the	DT
cord-272051-arz8r204	120	16	appropriate	appropriate	JJ
cord-272051-arz8r204	120	17	medium	medium	NN
cord-272051-arz8r204	120	18	.	.	.
cord-272051-arz8r204	121	1	In	in	IN
cord-272051-arz8r204	121	2	these	these	DT
cord-272051-arz8r204	121	3	conditions	condition	NNS
cord-272051-arz8r204	121	4	,	,	,
cord-272051-arz8r204	121	5	no	no	DT
cord-272051-arz8r204	121	6	inhibition	inhibition	NN
cord-272051-arz8r204	121	7	of	of	IN
cord-272051-arz8r204	121	8	the	the	DT
cord-272051-arz8r204	121	9	replication	replication	NN
cord-272051-arz8r204	121	10	of	of	IN
cord-272051-arz8r204	121	11	both	both	CC
cord-272051-arz8r204	121	12	VSV	VSV	NNP
cord-272051-arz8r204	121	13	and	and	CC
cord-272051-arz8r204	121	14	influenza	influenza	NN
cord-272051-arz8r204	121	15	virus	virus	NN
cord-272051-arz8r204	121	16	was	be	VBD
cord-272051-arz8r204	121	17	detectable	detectable	JJ
cord-272051-arz8r204	121	18	(	(	-LRB-
cord-272051-arz8r204	121	19	Fig	fig	NN
cord-272051-arz8r204	121	20	.	.	.
cord-272051-arz8r204	121	21	5A	5a	CD
cord-272051-arz8r204	121	22	)	)	-RRB-
cord-272051-arz8r204	121	23	.	.	.
cord-272051-arz8r204	122	1	Alternatively	alternatively	RB
cord-272051-arz8r204	122	2	,	,	,
cord-272051-arz8r204	122	3	PIs	pi	NNS
cord-272051-arz8r204	122	4	were	be	VBD
cord-272051-arz8r204	122	5	added	add	VBN
cord-272051-arz8r204	122	6	soon	soon	RB
cord-272051-arz8r204	122	7	after	after	IN
cord-272051-arz8r204	122	8	the	the	DT
cord-272051-arz8r204	122	9	virus	virus	NN
cord-272051-arz8r204	122	10	adsorption	adsorption	NN
cord-272051-arz8r204	122	11	or	or	CC
cord-272051-arz8r204	122	12	at	at	IN
cord-272051-arz8r204	122	13	different	different	JJ
cord-272051-arz8r204	122	14	times	time	NNS
cord-272051-arz8r204	122	15	after	after	IN
cord-272051-arz8r204	122	16	the	the	DT
cord-272051-arz8r204	122	17	challenge	challenge	NN
cord-272051-arz8r204	122	18	within	within	IN
cord-272051-arz8r204	122	19	a	a	DT
cord-272051-arz8r204	122	20	timeframe	timeframe	NN
cord-272051-arz8r204	122	21	of	of	IN
cord-272051-arz8r204	122	22	8	8	CD
cord-272051-arz8r204	122	23	h	h	NN
cord-272051-arz8r204	122	24	(	(	-LRB-
cord-272051-arz8r204	122	25	for	for	IN
cord-272051-arz8r204	122	26	VSV	VSV	NNP
cord-272051-arz8r204	122	27	infection	infection	NN
cord-272051-arz8r204	122	28	)	)	-RRB-
cord-272051-arz8r204	122	29	and	and	CC
cord-272051-arz8r204	122	30	24	24	CD
cord-272051-arz8r204	122	31	h	h	NN
cord-272051-arz8r204	122	32	(	(	-LRB-
cord-272051-arz8r204	122	33	in	in	IN
cord-272051-arz8r204	122	34	the	the	DT
cord-272051-arz8r204	122	35	case	case	NN
cord-272051-arz8r204	122	36	of	of	IN
cord-272051-arz8r204	122	37	challenge	challenge	NN
cord-272051-arz8r204	122	38	with	with	IN
cord-272051-arz8r204	122	39	influenza	influenza	NN
cord-272051-arz8r204	122	40	virus	virus	NN
cord-272051-arz8r204	122	41	)	)	-RRB-
cord-272051-arz8r204	122	42	,	,	,
cord-272051-arz8r204	122	43	i.e.	i.e.	FW
cord-272051-arz8r204	122	44	the	the	DT
cord-272051-arz8r204	122	45	respective	respective	JJ
cord-272051-arz8r204	122	46	replication	replication	NN
cord-272051-arz8r204	122	47	times	time	NNS
cord-272051-arz8r204	122	48	.	.	.
cord-272051-arz8r204	123	1	The	the	DT
cord-272051-arz8r204	123	2	supernatants	supernatant	NNS
cord-272051-arz8r204	123	3	were	be	VBD
cord-272051-arz8r204	123	4	harvested	harvest	VBN
cord-272051-arz8r204	123	5	8	8	CD
cord-272051-arz8r204	123	6	h	h	NN
cord-272051-arz8r204	123	7	(	(	-LRB-
cord-272051-arz8r204	123	8	for	for	IN
cord-272051-arz8r204	123	9	VSV	VSV	NNP
cord-272051-arz8r204	123	10	)	)	-RRB-
cord-272051-arz8r204	123	11	and	and	CC
cord-272051-arz8r204	123	12	24	24	CD
cord-272051-arz8r204	123	13	h	h	NN
cord-272051-arz8r204	123	14	(	(	-LRB-
cord-272051-arz8r204	123	15	for	for	IN
cord-272051-arz8r204	123	16	influenza	influenza	NN
cord-272051-arz8r204	123	17	virus	virus	NN
cord-272051-arz8r204	123	18	)	)	-RRB-
cord-272051-arz8r204	123	19	post	post	NN
cord-272051-arz8r204	123	20	-	-	NN
cord-272051-arz8r204	123	21	infection	infection	NN
cord-272051-arz8r204	123	22	,	,	,
cord-272051-arz8r204	123	23	and	and	CC
cord-272051-arz8r204	123	24	titrated	titrate	VBN
cord-272051-arz8r204	123	25	for	for	IN
cord-272051-arz8r204	123	26	the	the	DT
cord-272051-arz8r204	123	27	amounts	amount	NNS
cord-272051-arz8r204	123	28	of	of	IN
cord-272051-arz8r204	123	29	infectious	infectious	JJ
cord-272051-arz8r204	123	30	virus	virus	NN
cord-272051-arz8r204	123	31	particles	particle	NNS
cord-272051-arz8r204	123	32	.	.	.
cord-272051-arz8r204	124	1	It	-PRON-	PRP
cord-272051-arz8r204	124	2	appeared	appear	VBD
cord-272051-arz8r204	124	3	that	that	IN
cord-272051-arz8r204	124	4	PIs	pi	NNS
cord-272051-arz8r204	124	5	inhibited	inhibit	VBD
cord-272051-arz8r204	124	6	the	the	DT
cord-272051-arz8r204	124	7	virus	virus	NN
cord-272051-arz8r204	124	8	replication	replication	NN
cord-272051-arz8r204	124	9	also	also	RB
cord-272051-arz8r204	124	10	when	when	WRB
cord-272051-arz8r204	124	11	added	add	VBN
cord-272051-arz8r204	124	12	early	early	RB
cord-272051-arz8r204	124	13	after	after	IN
cord-272051-arz8r204	124	14	challenge	challenge	NN
cord-272051-arz8r204	124	15	(	(	-LRB-
cord-272051-arz8r204	124	16	Fig	Fig	NNP
cord-272051-arz8r204	124	17	.	.	.
cord-272051-arz8r204	124	18	5B	5b	CD
cord-272051-arz8r204	124	19	)	)	-RRB-
cord-272051-arz8r204	124	20	.	.	.
cord-272051-arz8r204	125	1	The	the	DT
cord-272051-arz8r204	125	2	inhibitory	inhibitory	JJ
cord-272051-arz8r204	125	3	effect	effect	NN
cord-272051-arz8r204	125	4	dropped	drop	VBD
cord-272051-arz8r204	125	5	shortly	shortly	RB
cord-272051-arz8r204	125	6	in	in	IN
cord-272051-arz8r204	125	7	the	the	DT
cord-272051-arz8r204	125	8	case	case	NN
cord-272051-arz8r204	125	9	of	of	IN
cord-272051-arz8r204	125	10	VSV	VSV	NNP
cord-272051-arz8r204	125	11	infection	infection	NN
cord-272051-arz8r204	125	12	,	,	,
cord-272051-arz8r204	125	13	and	and	CC
cord-272051-arz8r204	125	14	more	more	RBR
cord-272051-arz8r204	125	15	gradually	gradually	RB
cord-272051-arz8r204	125	16	when	when	WRB
cord-272051-arz8r204	125	17	cells	cell	NNS
cord-272051-arz8r204	125	18	were	be	VBD
cord-272051-arz8r204	125	19	infected	infect	VBN
cord-272051-arz8r204	125	20	with	with	IN
cord-272051-arz8r204	125	21	influenza	influenza	NN
cord-272051-arz8r204	125	22	virus	virus	NN
cord-272051-arz8r204	125	23	.	.	.
cord-272051-arz8r204	126	1	Saquinavir	Saquinavir	NNP
cord-272051-arz8r204	126	2	and	and	CC
cord-272051-arz8r204	126	3	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	126	4	have	have	VBP
cord-272051-arz8r204	126	5	shown	show	VBN
cord-272051-arz8r204	126	6	similar	similar	JJ
cord-272051-arz8r204	126	7	inhibitory	inhibitory	JJ
cord-272051-arz8r204	126	8	efficiencies	efficiency	NNS
cord-272051-arz8r204	126	9	(	(	-LRB-
cord-272051-arz8r204	126	10	not	not	RB
cord-272051-arz8r204	126	11	shown	show	VBN
cord-272051-arz8r204	126	12	)	)	-RRB-
cord-272051-arz8r204	126	13	.	.	.
cord-272051-arz8r204	127	1	These	these	DT
cord-272051-arz8r204	127	2	results	result	NNS
cord-272051-arz8r204	127	3	indicate	indicate	VBP
cord-272051-arz8r204	127	4	that	that	IN
cord-272051-arz8r204	127	5	the	the	DT
cord-272051-arz8r204	127	6	presence	presence	NN
cord-272051-arz8r204	127	7	of	of	IN
cord-272051-arz8r204	127	8	PIs	pi	NNS
cord-272051-arz8r204	127	9	at	at	IN
cord-272051-arz8r204	127	10	early	early	JJ
cord-272051-arz8r204	127	11	times	time	NNS
cord-272051-arz8r204	127	12	after	after	IN
cord-272051-arz8r204	127	13	virus	virus	NN
cord-272051-arz8r204	127	14	challenge	challenge	NN
cord-272051-arz8r204	127	15	is	be	VBZ
cord-272051-arz8r204	127	16	mandatory	mandatory	JJ
cord-272051-arz8r204	127	17	for	for	IN
cord-272051-arz8r204	127	18	the	the	DT
cord-272051-arz8r204	127	19	inhibitory	inhibitory	JJ
cord-272051-arz8r204	127	20	effect	effect	NN
cord-272051-arz8r204	127	21	,	,	,
cord-272051-arz8r204	127	22	consistently	consistently	RB
cord-272051-arz8r204	127	23	with	with	IN
cord-272051-arz8r204	127	24	the	the	DT
cord-272051-arz8r204	127	25	idea	idea	NN
cord-272051-arz8r204	127	26	that	that	WDT
cord-272051-arz8r204	127	27	PIs	pi	NNS
cord-272051-arz8r204	127	28	target	target	VB
cord-272051-arz8r204	127	29	an	an	DT
cord-272051-arz8r204	127	30	early	early	JJ
cord-272051-arz8r204	127	31	event	event	NN
cord-272051-arz8r204	127	32	of	of	IN
cord-272051-arz8r204	127	33	the	the	DT
cord-272051-arz8r204	127	34	replication	replication	NN
cord-272051-arz8r204	127	35	cycle	cycle	NN
cord-272051-arz8r204	127	36	of	of	IN
cord-272051-arz8r204	127	37	both	both	DT
cord-272051-arz8r204	127	38	viruses	virus	NNS
cord-272051-arz8r204	127	39	.	.	.
cord-272051-arz8r204	128	1	VSV	VSV	NNP
cord-272051-arz8r204	128	2	,	,	,
cord-272051-arz8r204	128	3	and	and	CC
cord-272051-arz8r204	128	4	(	(	-LRB-
cord-272051-arz8r204	128	5	VSV	VSV	NNP
cord-272051-arz8r204	128	6	-	-	HYPH
cord-272051-arz8r204	128	7	G	G	NNP
cord-272051-arz8r204	128	8	)	)	-RRB-
cord-272051-arz8r204	128	9	HIV-1	HIV-1	NNP
cord-272051-arz8r204	128	10	in	in	IN
cord-272051-arz8r204	128	11	an	an	DT
cord-272051-arz8r204	128	12	HIV-1	HIV-1	NNP
cord-272051-arz8r204	128	13	protease	protease	NN
cord-272051-arz8r204	128	14	independent	independent	JJ
cord-272051-arz8r204	128	15	manner	manner	NN
cord-272051-arz8r204	128	16	,	,	,
cord-272051-arz8r204	128	17	further	further	RB
cord-272051-arz8r204	128	18	supported	support	VBD
cord-272051-arz8r204	128	19	the	the	DT
cord-272051-arz8r204	128	20	idea	idea	NN
cord-272051-arz8r204	128	21	that	that	IN
cord-272051-arz8r204	128	22	PIs	pi	NNS
cord-272051-arz8r204	128	23	would	would	MD
cord-272051-arz8r204	128	24	influence	influence	VB
cord-272051-arz8r204	128	25	some	some	DT
cord-272051-arz8r204	128	26	common	common	JJ
cord-272051-arz8r204	128	27	early	early	JJ
cord-272051-arz8r204	128	28	replication	replication	NN
cord-272051-arz8r204	128	29	step	step	NN
cord-272051-arz8r204	128	30	,	,	,
cord-272051-arz8r204	128	31	e.g.	e.g.	RB
cord-272051-arz8r204	128	32	,	,	,
cord-272051-arz8r204	128	33	virus	virus	NN
cord-272051-arz8r204	128	34	attachment	attachment	NN
cord-272051-arz8r204	128	35	,	,	,
cord-272051-arz8r204	128	36	endocytosis	endocytosis	NN
cord-272051-arz8r204	128	37	,	,	,
cord-272051-arz8r204	128	38	and/or	and/or	CC
cord-272051-arz8r204	128	39	endosomal	endosomal	NNP
cord-272051-arz8r204	128	40	fusion	fusion	NN
cord-272051-arz8r204	128	41	.	.	.
cord-272051-arz8r204	129	1	To	to	TO
cord-272051-arz8r204	129	2	dissect	dissect	VB
cord-272051-arz8r204	129	3	among	among	IN
cord-272051-arz8r204	129	4	these	these	DT
cord-272051-arz8r204	129	5	different	different	JJ
cord-272051-arz8r204	129	6	possibilities	possibility	NNS
cord-272051-arz8r204	129	7	,	,	,
cord-272051-arz8r204	129	8	the	the	DT
cord-272051-arz8r204	129	9	intracellular	intracellular	JJ
cord-272051-arz8r204	129	10	fate	fate	NN
cord-272051-arz8r204	129	11	of	of	IN
cord-272051-arz8r204	129	12	challenging	challenging	JJ
cord-272051-arz8r204	129	13	virus	virus	NN
cord-272051-arz8r204	129	14	was	be	VBD
cord-272051-arz8r204	129	15	followed	follow	VBN
cord-272051-arz8r204	129	16	using	use	VBG
cord-272051-arz8r204	129	17	GFP	GFP	NNP
cord-272051-arz8r204	129	18	-	-	HYPH
cord-272051-arz8r204	129	19	labeled	label	VBN
cord-272051-arz8r204	129	20	HIV-1-based	hiv-1-based	JJ
cord-272051-arz8r204	129	21	VLPs	vlp	NNS
cord-272051-arz8r204	129	22	(	(	-LRB-
cord-272051-arz8r204	129	23	Muratori	Muratori	NNP
cord-272051-arz8r204	129	24	et	et	NNP
cord-272051-arz8r204	129	25	al	al	NNP
cord-272051-arz8r204	129	26	.	.	NNP
cord-272051-arz8r204	129	27	,	,	,
cord-272051-arz8r204	129	28	2006	2006	CD
cord-272051-arz8r204	129	29	)	)	-RRB-
cord-272051-arz8r204	129	30	pseudotyped	pseudotype	VBZ
cord-272051-arz8r204	129	31	with	with	IN
cord-272051-arz8r204	129	32	either	either	CC
cord-272051-arz8r204	129	33	wt	wt	NN
cord-272051-arz8r204	129	34	or	or	CC
cord-272051-arz8r204	129	35	fusiondefective	fusiondefective	JJ
cord-272051-arz8r204	129	36	VSV	VSV	NNP
cord-272051-arz8r204	129	37	-	-	HYPH
cord-272051-arz8r204	129	38	G	G	NNP
cord-272051-arz8r204	129	39	(	(	-LRB-
cord-272051-arz8r204	129	40	Fig	fig	NN
cord-272051-arz8r204	129	41	.	.	.
cord-272051-arz8r204	129	42	6A	6a	CD
cord-272051-arz8r204	129	43	)	)	-RRB-
cord-272051-arz8r204	129	44	.	.	.
cord-272051-arz8r204	130	1	The	the	DT
cord-272051-arz8r204	130	2	fluorescence	fluorescence	NN
cord-272051-arz8r204	130	3	of	of	IN
cord-272051-arz8r204	130	4	these	these	DT
cord-272051-arz8r204	130	5	VLPs	vlp	NNS
cord-272051-arz8r204	130	6	relies	rely	VBZ
cord-272051-arz8r204	130	7	on	on	IN
cord-272051-arz8r204	130	8	the	the	DT
cord-272051-arz8r204	130	9	high	high	JJ
cord-272051-arz8r204	130	10	incorporation	incorporation	NN
cord-272051-arz8r204	130	11	levels	level	NNS
cord-272051-arz8r204	130	12	of	of	IN
cord-272051-arz8r204	130	13	the	the	DT
cord-272051-arz8r204	130	14	product	product	NN
cord-272051-arz8r204	130	15	of	of	IN
cord-272051-arz8r204	130	16	fusion	fusion	NN
cord-272051-arz8r204	130	17	between	between	IN
cord-272051-arz8r204	130	18	GFP	GFP	NNP
cord-272051-arz8r204	130	19	and	and	CC
cord-272051-arz8r204	130	20	a	a	DT
cord-272051-arz8r204	130	21	HIV-1	HIV-1	NNP
cord-272051-arz8r204	130	22	Nef	Nef	NNP
cord-272051-arz8r204	130	23	mutant	mutant	NN
cord-272051-arz8r204	130	24	acquiring	acquire	VBG
cord-272051-arz8r204	130	25	a	a	DT
cord-272051-arz8r204	130	26	palmitoylation	palmitoylation	NN
cord-272051-arz8r204	130	27	site	site	NN
cord-272051-arz8r204	130	28	at	at	IN
cord-272051-arz8r204	130	29	its	-PRON-	PRP$
cord-272051-arz8r204	130	30	N	n	CD
cord-272051-arz8r204	130	31	-	-	HYPH
cord-272051-arz8r204	130	32	terminus	terminus	NN
cord-272051-arz8r204	130	33	as	as	IN
cord-272051-arz8r204	130	34	the	the	DT
cord-272051-arz8r204	130	35	consequence	consequence	NN
cord-272051-arz8r204	130	36	of	of	IN
cord-272051-arz8r204	130	37	the	the	DT
cord-272051-arz8r204	130	38	G	g	NN
cord-272051-arz8r204	130	39	to	to	IN
cord-272051-arz8r204	130	40	C	c	NN
cord-272051-arz8r204	130	41	substitution	substitution	NN
cord-272051-arz8r204	130	42	at	at	IN
cord-272051-arz8r204	130	43	the	the	DT
cord-272051-arz8r204	130	44	amino	amino	NN
cord-272051-arz8r204	130	45	acid	acid	NN
cord-272051-arz8r204	130	46	3	3	CD
cord-272051-arz8r204	130	47	.	.	.
cord-272051-arz8r204	131	1	First	first	RB
cord-272051-arz8r204	131	2	,	,	,
cord-272051-arz8r204	131	3	the	the	DT
cord-272051-arz8r204	131	4	possible	possible	JJ
cord-272051-arz8r204	131	5	effects	effect	NNS
cord-272051-arz8r204	131	6	of	of	IN
cord-272051-arz8r204	131	7	PIs	pi	NNS
cord-272051-arz8r204	131	8	on	on	IN
cord-272051-arz8r204	131	9	the	the	DT
cord-272051-arz8r204	131	10	virus	virus	NN
cord-272051-arz8r204	131	11	attachment	attachment	NN
cord-272051-arz8r204	131	12	on	on	IN
cord-272051-arz8r204	131	13	target	target	NN
cord-272051-arz8r204	131	14	cells	cell	NNS
cord-272051-arz8r204	131	15	were	be	VBD
cord-272051-arz8r204	131	16	investigated	investigate	VBN
cord-272051-arz8r204	131	17	.	.	.
cord-272051-arz8r204	132	1	To	to	IN
cord-272051-arz8r204	132	2	this	this	DT
cord-272051-arz8r204	132	3	end	end	NN
cord-272051-arz8r204	132	4	,	,	,
cord-272051-arz8r204	132	5	10	10	CD
cord-272051-arz8r204	132	6	5	5	CD
cord-272051-arz8r204	132	7	HeLa	HeLa	NNP
cord-272051-arz8r204	132	8	cells	cell	NNS
cord-272051-arz8r204	132	9	treated	treat	VBN
cord-272051-arz8r204	132	10	or	or	CC
cord-272051-arz8r204	132	11	not	not	RB
cord-272051-arz8r204	132	12	with	with	IN
cord-272051-arz8r204	132	13	PIs	pi	NNS
cord-272051-arz8r204	132	14	were	be	VBD
cord-272051-arz8r204	132	15	challenged	challenge	VBN
cord-272051-arz8r204	132	16	with	with	IN
cord-272051-arz8r204	132	17	500	500	CD
cord-272051-arz8r204	132	18	ng	ng	NN
cord-272051-arz8r204	132	19	of	of	IN
cord-272051-arz8r204	133	1	(	(	-LRB-
cord-272051-arz8r204	133	2	wt	wt	NNP
cord-272051-arz8r204	133	3	VSV	VSV	NNP
cord-272051-arz8r204	133	4	-	-	HYPH
cord-272051-arz8r204	133	5	G	G	NNP
cord-272051-arz8r204	133	6	)	)	-RRB-
cord-272051-arz8r204	133	7	Nef	Nef	NNP
cord-272051-arz8r204	133	8	G3C	G3C	NNS
cord-272051-arz8r204	133	9	-GFP	-gfp	DT
cord-272051-arz8r204	133	10	VLPs	vlp	NNS
cord-272051-arz8r204	133	11	for	for	IN
cord-272051-arz8r204	133	12	1	1	CD
cord-272051-arz8r204	133	13	h	h	NN
cord-272051-arz8r204	133	14	at	at	IN
cord-272051-arz8r204	133	15	4	4	CD
cord-272051-arz8r204	133	16	°	°	NN
cord-272051-arz8r204	133	17	C	c	NN
cord-272051-arz8r204	133	18	.	.	.
cord-272051-arz8r204	134	1	Afterwards	afterwards	RB
cord-272051-arz8r204	134	2	,	,	,
cord-272051-arz8r204	134	3	the	the	DT
cord-272051-arz8r204	134	4	cells	cell	NNS
cord-272051-arz8r204	134	5	were	be	VBD
cord-272051-arz8r204	134	6	extensively	extensively	RB
cord-272051-arz8r204	134	7	washed	wash	VBN
cord-272051-arz8r204	134	8	and	and	CC
cord-272051-arz8r204	134	9	FACS	FACS	NNP
cord-272051-arz8r204	134	10	analyzed	analyze	VBD
cord-272051-arz8r204	134	11	.	.	.
cord-272051-arz8r204	135	1	To	to	TO
cord-272051-arz8r204	135	2	control	control	VB
cord-272051-arz8r204	135	3	that	that	IN
cord-272051-arz8r204	135	4	the	the	DT
cord-272051-arz8r204	135	5	cell	cell	NN
cord-272051-arz8r204	135	6	-	-	HYPH
cord-272051-arz8r204	135	7	associated	associate	VBN
cord-272051-arz8r204	135	8	fluorescence	fluorescence	NN
cord-272051-arz8r204	135	9	was	be	VBD
cord-272051-arz8r204	135	10	not	not	RB
cord-272051-arz8r204	135	11	a	a	DT
cord-272051-arz8r204	135	12	consequence	consequence	NN
cord-272051-arz8r204	135	13	of	of	IN
cord-272051-arz8r204	135	14	endocytosed	endocytosed	JJ
cord-272051-arz8r204	135	15	VLPs	vlp	NNS
cord-272051-arz8r204	135	16	,	,	,
cord-272051-arz8r204	135	17	a	a	DT
cord-272051-arz8r204	135	18	part	part	NN
cord-272051-arz8r204	135	19	of	of	IN
cord-272051-arz8r204	135	20	the	the	DT
cord-272051-arz8r204	135	21	cell	cell	NN
cord-272051-arz8r204	135	22	samples	sample	NNS
cord-272051-arz8r204	135	23	was	be	VBD
cord-272051-arz8r204	135	24	treated	treat	VBN
cord-272051-arz8r204	135	25	with	with	IN
cord-272051-arz8r204	135	26	trypsin	trypsin	NN
cord-272051-arz8r204	135	27	.	.	.
cord-272051-arz8r204	136	1	It	-PRON-	PRP
cord-272051-arz8r204	136	2	appeared	appear	VBD
cord-272051-arz8r204	136	3	that	that	IN
cord-272051-arz8r204	136	4	the	the	DT
cord-272051-arz8r204	136	5	treatment	treatment	NN
cord-272051-arz8r204	136	6	with	with	IN
cord-272051-arz8r204	136	7	PIs	pi	NNS
cord-272051-arz8r204	136	8	did	do	VBD
cord-272051-arz8r204	136	9	not	not	RB
cord-272051-arz8r204	136	10	significantly	significantly	RB
cord-272051-arz8r204	136	11	affect	affect	VB
cord-272051-arz8r204	136	12	the	the	DT
cord-272051-arz8r204	136	13	cell	cell	NN
cord-272051-arz8r204	136	14	binding	bind	VBG
cord-272051-arz8r204	136	15	of	of	IN
cord-272051-arz8r204	136	16	fluorescent	fluorescent	JJ
cord-272051-arz8r204	136	17	VLPs	vlp	NNS
cord-272051-arz8r204	136	18	(	(	-LRB-
cord-272051-arz8r204	136	19	Fig	Fig	NNP
cord-272051-arz8r204	136	20	.	.	.
cord-272051-arz8r204	136	21	6B	6b	CD
cord-272051-arz8r204	136	22	)	)	-RRB-
cord-272051-arz8r204	136	23	.	.	.
cord-272051-arz8r204	137	1	This	this	DT
cord-272051-arz8r204	137	2	strongly	strongly	RB
cord-272051-arz8r204	137	3	suggests	suggest	VBZ
cord-272051-arz8r204	137	4	that	that	IN
cord-272051-arz8r204	137	5	PIs	pi	NNS
cord-272051-arz8r204	137	6	do	do	VBP
cord-272051-arz8r204	137	7	not	not	RB
cord-272051-arz8r204	137	8	interfere	interfere	VB
cord-272051-arz8r204	137	9	with	with	IN
cord-272051-arz8r204	137	10	the	the	DT
cord-272051-arz8r204	137	11	binding	binding	NN
cord-272051-arz8r204	137	12	of	of	IN
cord-272051-arz8r204	137	13	viral	viral	JJ
cord-272051-arz8r204	137	14	particles	particle	NNS
cord-272051-arz8r204	137	15	on	on	IN
cord-272051-arz8r204	137	16	the	the	DT
cord-272051-arz8r204	137	17	cell	cell	NN
cord-272051-arz8r204	137	18	membrane	membrane	NN
cord-272051-arz8r204	137	19	.	.	.
cord-272051-arz8r204	138	1	Next	next	RB
cord-272051-arz8r204	138	2	,	,	,
cord-272051-arz8r204	138	3	the	the	DT
cord-272051-arz8r204	138	4	influence	influence	NN
cord-272051-arz8r204	138	5	of	of	IN
cord-272051-arz8r204	138	6	PIs	pi	NNS
cord-272051-arz8r204	138	7	on	on	IN
cord-272051-arz8r204	138	8	virus	virus	NN
cord-272051-arz8r204	138	9	endocytosis	endocytosis	NN
cord-272051-arz8r204	138	10	was	be	VBD
cord-272051-arz8r204	138	11	investigated	investigate	VBN
cord-272051-arz8r204	138	12	.	.	.
cord-272051-arz8r204	139	1	To	to	IN
cord-272051-arz8r204	139	2	this	this	DT
cord-272051-arz8r204	139	3	aim	aim	NN
cord-272051-arz8r204	139	4	,	,	,
cord-272051-arz8r204	139	5	GFP	GFP	NNP
cord-272051-arz8r204	139	6	-	-	HYPH
cord-272051-arz8r204	139	7	fluorescent	fluorescent	JJ
cord-272051-arz8r204	139	8	VLPs	vlp	NNS
cord-272051-arz8r204	139	9	incorporating	incorporate	VBG
cord-272051-arz8r204	139	10	a	a	DT
cord-272051-arz8r204	139	11	VSV	VSV	NNP
cord-272051-arz8r204	139	12	-	-	HYPH
cord-272051-arz8r204	139	13	G	G	NNP
cord-272051-arz8r204	139	14	mutant	mutant	NN
cord-272051-arz8r204	139	15	(	(	-LRB-
cord-272051-arz8r204	139	16	here	here	RB
cord-272051-arz8r204	139	17	referred	refer	VBN
cord-272051-arz8r204	139	18	to	to	IN
cord-272051-arz8r204	139	19	as	as	IN
cord-272051-arz8r204	139	20	fd	fd	NNP
cord-272051-arz8r204	139	21	VSV	VSV	NNP
cord-272051-arz8r204	139	22	-	-	HYPH
cord-272051-arz8r204	139	23	G	G	NNP
cord-272051-arz8r204	139	24	)	)	-RRB-
cord-272051-arz8r204	139	25	unable	unable	JJ
cord-272051-arz8r204	139	26	to	to	TO
cord-272051-arz8r204	139	27	support	support	VB
cord-272051-arz8r204	139	28	the	the	DT
cord-272051-arz8r204	139	29	pH	ph	JJ
cord-272051-arz8r204	139	30	-	-	HYPH
cord-272051-arz8r204	139	31	dependent	dependent	JJ
cord-272051-arz8r204	139	32	fusion	fusion	NN
cord-272051-arz8r204	139	33	were	be	VBD
cord-272051-arz8r204	139	34	used	use	VBN
cord-272051-arz8r204	139	35	.	.	.
cord-272051-arz8r204	140	1	The	the	DT
cord-272051-arz8r204	140	2	impaired	impaired	JJ
cord-272051-arz8r204	140	3	fusion	fusion	NN
cord-272051-arz8r204	140	4	activity	activity	NN
cord-272051-arz8r204	140	5	was	be	VBD
cord-272051-arz8r204	140	6	a	a	DT
cord-272051-arz8r204	140	7	consequence	consequence	NN
cord-272051-arz8r204	140	8	of	of	IN
cord-272051-arz8r204	140	9	the	the	DT
cord-272051-arz8r204	140	10	A	a	NN
cord-272051-arz8r204	140	11	to	to	IN
cord-272051-arz8r204	140	12	K	k	NN
cord-272051-arz8r204	140	13	amino	amino	NN
cord-272051-arz8r204	140	14	acid	acid	NN
cord-272051-arz8r204	140	15	substitution	substitution	NN
cord-272051-arz8r204	140	16	at	at	IN
cord-272051-arz8r204	140	17	the	the	DT
cord-272051-arz8r204	140	18	position	position	NN
cord-272051-arz8r204	140	19	133	133	CD
cord-272051-arz8r204	140	20	(	(	-LRB-
cord-272051-arz8r204	140	21	Fredericksen	Fredericksen	NNP
cord-272051-arz8r204	140	22	and	and	CC
cord-272051-arz8r204	140	23	Whitt	Whitt	NNP
cord-272051-arz8r204	140	24	,	,	,
cord-272051-arz8r204	140	25	1995	1995	CD
cord-272051-arz8r204	140	26	)	)	-RRB-
cord-272051-arz8r204	140	27	.	.	.
cord-272051-arz8r204	141	1	The	the	DT
cord-272051-arz8r204	141	2	use	use	NN
cord-272051-arz8r204	141	3	of	of	IN
cord-272051-arz8r204	141	4	this	this	DT
cord-272051-arz8r204	141	5	envelope	envelope	NN
cord-272051-arz8r204	141	6	protein	protein	NN
cord-272051-arz8r204	141	7	mutant	mutant	NN
cord-272051-arz8r204	141	8	was	be	VBD
cord-272051-arz8r204	141	9	associated	associate	VBN
cord-272051-arz8r204	141	10	with	with	IN
cord-272051-arz8r204	141	11	the	the	DT
cord-272051-arz8r204	141	12	trypsin	trypsin	NN
cord-272051-arz8r204	141	13	treatment	treatment	NN
cord-272051-arz8r204	141	14	just	just	RB
cord-272051-arz8r204	141	15	before	before	IN
cord-272051-arz8r204	141	16	the	the	DT
cord-272051-arz8r204	141	17	FACS	FACS	NNP
cord-272051-arz8r204	141	18	analysis	analysis	NN
cord-272051-arz8r204	141	19	to	to	TO
cord-272051-arz8r204	141	20	ensure	ensure	VB
cord-272051-arz8r204	141	21	that	that	IN
cord-272051-arz8r204	141	22	the	the	DT
cord-272051-arz8r204	141	23	cell	cell	NN
cord-272051-arz8r204	141	24	-	-	HYPH
cord-272051-arz8r204	141	25	associated	associate	VBN
cord-272051-arz8r204	141	26	fluorescent	fluorescent	NN
cord-272051-arz8r204	141	27	signal	signal	NN
cord-272051-arz8r204	141	28	exclusively	exclusively	RB
cord-272051-arz8r204	141	29	referred	refer	VBD
cord-272051-arz8r204	141	30	to	to	IN
cord-272051-arz8r204	141	31	the	the	DT
cord-272051-arz8r204	141	32	intracellular	intracellular	JJ
cord-272051-arz8r204	141	33	accumulation	accumulation	NN
cord-272051-arz8r204	141	34	of	of	IN
cord-272051-arz8r204	141	35	VLPs	vlp	NNS
cord-272051-arz8r204	141	36	.	.	.
cord-272051-arz8r204	142	1	HeLa	HeLa	NNP
cord-272051-arz8r204	142	2	cells	cell	NNS
cord-272051-arz8r204	142	3	treated	treat	VBN
cord-272051-arz8r204	142	4	or	or	CC
cord-272051-arz8r204	142	5	not	not	RB
cord-272051-arz8r204	142	6	with	with	IN
cord-272051-arz8r204	142	7	PIs	pi	NNS
cord-272051-arz8r204	142	8	were	be	VBD
cord-272051-arz8r204	142	9	challenged	challenge	VBN
cord-272051-arz8r204	142	10	with	with	IN
cord-272051-arz8r204	142	11	500	500	CD
cord-272051-arz8r204	142	12	ng	ng	NNP
cord-272051-arz8r204	142	13	HIV-1	HIV-1	NNP
cord-272051-arz8r204	142	14	CAp24	cap24	IN
cord-272051-arz8r204	142	15	equivalents	equivalent	NNS
cord-272051-arz8r204	142	16	of	of	IN
cord-272051-arz8r204	143	1	(	(	-LRB-
cord-272051-arz8r204	143	2	fd	fd	NNP
cord-272051-arz8r204	143	3	VSV	VSV	NNP
cord-272051-arz8r204	143	4	-	-	HYPH
cord-272051-arz8r204	143	5	G	G	NNP
cord-272051-arz8r204	143	6	)	)	-RRB-
cord-272051-arz8r204	143	7	Nef	Nef	NNP
cord-272051-arz8r204	143	8	G3C	G3C	NNS
cord-272051-arz8r204	143	9	-GFP	-gfp	ADD
cord-272051-arz8r204	144	1	VLPs/10	VLPs/10	NNP
cord-272051-arz8r204	144	2	5	5	CD
cord-272051-arz8r204	144	3	cells	cell	NNS
cord-272051-arz8r204	144	4	,	,	,
cord-272051-arz8r204	144	5	and	and	CC
cord-272051-arz8r204	144	6	incubated	incubate	VBN
cord-272051-arz8r204	144	7	for	for	IN
cord-272051-arz8r204	144	8	3	3	CD
cord-272051-arz8r204	144	9	h	h	NN
cord-272051-arz8r204	144	10	at	at	IN
cord-272051-arz8r204	144	11	37	37	CD
cord-272051-arz8r204	144	12	°	°	NN
cord-272051-arz8r204	144	13	C	c	NN
cord-272051-arz8r204	144	14	in	in	IN
cord-272051-arz8r204	144	15	the	the	DT
cord-272051-arz8r204	144	16	presence	presence	NN
cord-272051-arz8r204	144	17	or	or	CC
cord-272051-arz8r204	144	18	not	not	RB
cord-272051-arz8r204	144	19	of	of	IN
cord-272051-arz8r204	144	20	PIs	pi	NNS
cord-272051-arz8r204	144	21	.	.	.
cord-272051-arz8r204	145	1	Then	then	RB
cord-272051-arz8r204	145	2	,	,	,
cord-272051-arz8r204	145	3	the	the	DT
cord-272051-arz8r204	145	4	cells	cell	NNS
cord-272051-arz8r204	145	5	were	be	VBD
cord-272051-arz8r204	145	6	treated	treat	VBN
cord-272051-arz8r204	145	7	with	with	IN
cord-272051-arz8r204	145	8	trypsin	trypsin	NN
cord-272051-arz8r204	145	9	,	,	,
cord-272051-arz8r204	145	10	and	and	CC
cord-272051-arz8r204	145	11	the	the	DT
cord-272051-arz8r204	145	12	cell	cell	NN
cord-272051-arz8r204	145	13	-	-	HYPH
cord-272051-arz8r204	145	14	associated	associate	VBN
cord-272051-arz8r204	145	15	GFP	GFP	NNP
cord-272051-arz8r204	145	16	fluorescence	fluorescence	NN
cord-272051-arz8r204	145	17	was	be	VBD
cord-272051-arz8r204	145	18	evaluated	evaluate	VBN
cord-272051-arz8r204	145	19	by	by	IN
cord-272051-arz8r204	145	20	FACS	FACS	NNP
cord-272051-arz8r204	145	21	analysis	analysis	NN
cord-272051-arz8r204	145	22	.	.	.
cord-272051-arz8r204	146	1	As	as	IN
cord-272051-arz8r204	146	2	control	control	NN
cord-272051-arz8r204	146	3	,	,	,
cord-272051-arz8r204	146	4	VLP	VLP	NNP
cord-272051-arz8r204	146	5	-	-	HYPH
cord-272051-arz8r204	146	6	challenged	challenge	VBN
cord-272051-arz8r204	146	7	cells	cell	NNS
cord-272051-arz8r204	146	8	were	be	VBD
cord-272051-arz8r204	146	9	incubated	incubate	VBN
cord-272051-arz8r204	146	10	at	at	IN
cord-272051-arz8r204	146	11	4	4	CD
cord-272051-arz8r204	146	12	°	°	NN
cord-272051-arz8r204	146	13	C	c	NN
cord-272051-arz8r204	146	14	before	before	IN
cord-272051-arz8r204	146	15	the	the	DT
cord-272051-arz8r204	146	16	trypsin	trypsin	NN
cord-272051-arz8r204	146	17	treatment	treatment	NN
cord-272051-arz8r204	146	18	.	.	.
cord-272051-arz8r204	147	1	Again	again	RB
cord-272051-arz8r204	147	2	,	,	,
cord-272051-arz8r204	147	3	no	no	DT
cord-272051-arz8r204	147	4	apparent	apparent	JJ
cord-272051-arz8r204	147	5	differences	difference	NNS
cord-272051-arz8r204	147	6	in	in	IN
cord-272051-arz8r204	147	7	the	the	DT
cord-272051-arz8r204	147	8	cellassociated	cellassociate	VBN
cord-272051-arz8r204	147	9	fluorescence	fluorescence	NN
cord-272051-arz8r204	147	10	were	be	VBD
cord-272051-arz8r204	147	11	detected	detect	VBN
cord-272051-arz8r204	147	12	between	between	IN
cord-272051-arz8r204	147	13	control	control	NN
cord-272051-arz8r204	147	14	and	and	CC
cord-272051-arz8r204	147	15	PI	pi	NN
cord-272051-arz8r204	147	16	-	-	HYPH
cord-272051-arz8r204	147	17	treated	treat	VBN
cord-272051-arz8r204	147	18	cells	cell	NNS
cord-272051-arz8r204	147	19	(	(	-LRB-
cord-272051-arz8r204	147	20	Fig	Fig	NNP
cord-272051-arz8r204	147	21	.	.	.
cord-272051-arz8r204	147	22	6C	6C	NNP
cord-272051-arz8r204	147	23	)	)	-RRB-
cord-272051-arz8r204	147	24	,	,	,
cord-272051-arz8r204	147	25	suggesting	suggest	VBG
cord-272051-arz8r204	147	26	that	that	IN
cord-272051-arz8r204	147	27	PIs	pi	NNS
cord-272051-arz8r204	147	28	have	have	VBP
cord-272051-arz8r204	147	29	no	no	DT
cord-272051-arz8r204	147	30	influence	influence	NN
cord-272051-arz8r204	147	31	on	on	IN
cord-272051-arz8r204	147	32	the	the	DT
cord-272051-arz8r204	147	33	efficiency	efficiency	NN
cord-272051-arz8r204	147	34	of	of	IN
cord-272051-arz8r204	147	35	the	the	DT
cord-272051-arz8r204	147	36	endocytosis	endocytosis	NN
cord-272051-arz8r204	147	37	of	of	IN
cord-272051-arz8r204	147	38	viral	viral	JJ
cord-272051-arz8r204	147	39	particles	particle	NNS
cord-272051-arz8r204	147	40	.	.	.
cord-272051-arz8r204	148	1	This	this	DT
cord-272051-arz8r204	148	2	conclusion	conclusion	NN
cord-272051-arz8r204	148	3	was	be	VBD
cord-272051-arz8r204	148	4	enforced	enforce	VBN
cord-272051-arz8r204	148	5	by	by	IN
cord-272051-arz8r204	148	6	the	the	DT
cord-272051-arz8r204	148	7	results	result	NNS
cord-272051-arz8r204	148	8	obtained	obtain	VBN
cord-272051-arz8r204	148	9	through	through	IN
cord-272051-arz8r204	148	10	an	an	DT
cord-272051-arz8r204	148	11	alternative	alternative	JJ
cord-272051-arz8r204	148	12	experimental	experimental	JJ
cord-272051-arz8r204	148	13	approach	approach	NN
cord-272051-arz8r204	148	14	where	where	WRB
cord-272051-arz8r204	148	15	control	control	NN
cord-272051-arz8r204	148	16	or	or	CC
cord-272051-arz8r204	148	17	PI	pi	NN
cord-272051-arz8r204	148	18	-	-	HYPH
cord-272051-arz8r204	148	19	treated	treat	VBN
cord-272051-arz8r204	148	20	HeLa	HeLa	NNP
cord-272051-arz8r204	148	21	cells	cell	NNS
cord-272051-arz8r204	148	22	were	be	VBD
cord-272051-arz8r204	148	23	infected	infect	VBN
cord-272051-arz8r204	148	24	with	with	IN
cord-272051-arz8r204	148	25	0.2	0.2	CD
cord-272051-arz8r204	148	26	pfu	pfu	NN
cord-272051-arz8r204	148	27	/	/	SYM
cord-272051-arz8r204	148	28	cell	cell	NN
cord-272051-arz8r204	148	29	of	of	IN
cord-272051-arz8r204	148	30	VSV	VSV	NNP
cord-272051-arz8r204	148	31	.	.	.
cord-272051-arz8r204	149	1	Thirty	thirty	CD
cord-272051-arz8r204	149	2	and	and	CC
cord-272051-arz8r204	149	3	60	60	CD
cord-272051-arz8r204	149	4	min	min	NN
cord-272051-arz8r204	149	5	later	later	RB
cord-272051-arz8r204	149	6	,	,	,
cord-272051-arz8r204	149	7	the	the	DT
cord-272051-arz8r204	149	8	cells	cell	NNS
cord-272051-arz8r204	149	9	were	be	VBD
cord-272051-arz8r204	149	10	extensively	extensively	RB
cord-272051-arz8r204	149	11	washed	wash	VBN
cord-272051-arz8r204	149	12	,	,	,
cord-272051-arz8r204	149	13	treated	treat	VBN
cord-272051-arz8r204	149	14	with	with	IN
cord-272051-arz8r204	149	15	trypsin	trypsin	NN
cord-272051-arz8r204	149	16	to	to	TO
cord-272051-arz8r204	149	17	leave	leave	VB
cord-272051-arz8r204	149	18	out	out	RP
cord-272051-arz8r204	149	19	non	non	JJ
cord-272051-arz8r204	149	20	-	-	JJ
cord-272051-arz8r204	149	21	adsorbed	adsorb	VBN
cord-272051-arz8r204	149	22	viral	viral	JJ
cord-272051-arz8r204	149	23	particles	particle	NNS
cord-272051-arz8r204	149	24	,	,	,
cord-272051-arz8r204	149	25	lysed	lyse	VBN
cord-272051-arz8r204	149	26	,	,	,
cord-272051-arz8r204	149	27	and	and	CC
cord-272051-arz8r204	149	28	analyzed	analyze	VBN
cord-272051-arz8r204	149	29	by	by	IN
cord-272051-arz8r204	149	30	western	western	JJ
cord-272051-arz8r204	149	31	blot	blot	NN
cord-272051-arz8r204	149	32	for	for	IN
cord-272051-arz8r204	149	33	the	the	DT
cord-272051-arz8r204	149	34	presence	presence	NN
cord-272051-arz8r204	149	35	of	of	IN
cord-272051-arz8r204	149	36	VSV	VSV	NNP
cord-272051-arz8r204	149	37	-	-	HYPH
cord-272051-arz8r204	149	38	G.	G.	NNP
cord-272051-arz8r204	150	1	No	no	DT
cord-272051-arz8r204	150	2	significant	significant	JJ
cord-272051-arz8r204	150	3	reduction	reduction	NN
cord-272051-arz8r204	150	4	of	of	IN
cord-272051-arz8r204	150	5	the	the	DT
cord-272051-arz8r204	150	6	VSV	VSV	NNP
cord-272051-arz8r204	150	7	-	-	HYPH
cord-272051-arz8r204	150	8	G	G	NNP
cord-272051-arz8r204	150	9	specific	specific	JJ
cord-272051-arz8r204	150	10	signals	signal	NNS
cord-272051-arz8r204	150	11	was	be	VBD
cord-272051-arz8r204	150	12	detectable	detectable	JJ
cord-272051-arz8r204	150	13	at	at	IN
cord-272051-arz8r204	150	14	both	both	DT
cord-272051-arz8r204	150	15	time	time	NN
cord-272051-arz8r204	150	16	points	point	NNS
cord-272051-arz8r204	150	17	in	in	IN
cord-272051-arz8r204	150	18	PI	pi	NN
cord-272051-arz8r204	150	19	-	-	HYPH
cord-272051-arz8r204	150	20	treated	treat	VBN
cord-272051-arz8r204	150	21	cells	cell	NNS
cord-272051-arz8r204	150	22	as	as	IN
cord-272051-arz8r204	150	23	compared	compare	VBN
cord-272051-arz8r204	150	24	to	to	IN
cord-272051-arz8r204	150	25	control	control	NN
cord-272051-arz8r204	150	26	conditions	condition	NNS
cord-272051-arz8r204	150	27	(	(	-LRB-
cord-272051-arz8r204	150	28	Fig	Fig	NNP
cord-272051-arz8r204	150	29	.	.	.
cord-272051-arz8r204	150	30	6D	6D	NNP
cord-272051-arz8r204	150	31	)	)	-RRB-
cord-272051-arz8r204	150	32	.	.	.
cord-272051-arz8r204	151	1	Considering	consider	VBG
cord-272051-arz8r204	151	2	that	that	IN
cord-272051-arz8r204	151	3	the	the	DT
cord-272051-arz8r204	151	4	neosynthesis	neosynthesis	NN
cord-272051-arz8r204	151	5	of	of	IN
cord-272051-arz8r204	151	6	VSV	VSV	NNP
cord-272051-arz8r204	151	7	-	-	HYPH
cord-272051-arz8r204	151	8	G	G	NNP
cord-272051-arz8r204	151	9	starts	start	VBZ
cord-272051-arz8r204	151	10	at	at	RB
cord-272051-arz8r204	151	11	least	least	JJS
cord-272051-arz8r204	151	12	90	90	CD
cord-272051-arz8r204	151	13	min	min	NN
cord-272051-arz8r204	151	14	post	post	NN
cord-272051-arz8r204	151	15	-	-	NN
cord-272051-arz8r204	151	16	infection	infection	NN
cord-272051-arz8r204	151	17	(	(	-LRB-
cord-272051-arz8r204	151	18	Rothman	Rothman	NNP
cord-272051-arz8r204	151	19	and	and	CC
cord-272051-arz8r204	151	20	Lodish	Lodish	NNP
cord-272051-arz8r204	151	21	,	,	,
cord-272051-arz8r204	151	22	1977	1977	CD
cord-272051-arz8r204	151	23	)	)	-RRB-
cord-272051-arz8r204	151	24	,	,	,
cord-272051-arz8r204	151	25	these	these	DT
cord-272051-arz8r204	151	26	results	result	NNS
cord-272051-arz8r204	151	27	,	,	,
cord-272051-arz8r204	151	28	consistently	consistently	RB
cord-272051-arz8r204	151	29	with	with	IN
cord-272051-arz8r204	151	30	the	the	DT
cord-272051-arz8r204	151	31	data	datum	NNS
cord-272051-arz8r204	151	32	obtained	obtain	VBN
cord-272051-arz8r204	151	33	with	with	IN
cord-272051-arz8r204	151	34	fluorescent	fluorescent	JJ
cord-272051-arz8r204	151	35	VLPs	vlp	NNS
cord-272051-arz8r204	151	36	,	,	,
cord-272051-arz8r204	151	37	suggest	suggest	VBP
cord-272051-arz8r204	151	38	that	that	IN
cord-272051-arz8r204	151	39	PIs	pi	NNS
cord-272051-arz8r204	151	40	do	do	VBP
cord-272051-arz8r204	151	41	not	not	RB
cord-272051-arz8r204	151	42	affect	affect	VB
cord-272051-arz8r204	151	43	the	the	DT
cord-272051-arz8r204	151	44	endocytosis	endocytosis	NN
cord-272051-arz8r204	151	45	of	of	IN
cord-272051-arz8r204	151	46	viral	viral	JJ
cord-272051-arz8r204	151	47	particles	particle	NNS
cord-272051-arz8r204	151	48	.	.	.
cord-272051-arz8r204	152	1	The	the	DT
cord-272051-arz8r204	152	2	results	result	NNS
cord-272051-arz8r204	152	3	from	from	IN
cord-272051-arz8r204	152	4	these	these	DT
cord-272051-arz8r204	152	5	experiments	experiment	NNS
cord-272051-arz8r204	152	6	indicate	indicate	VBP
cord-272051-arz8r204	152	7	that	that	IN
cord-272051-arz8r204	152	8	the	the	DT
cord-272051-arz8r204	152	9	inhibitory	inhibitory	JJ
cord-272051-arz8r204	152	10	effect	effect	NN
cord-272051-arz8r204	152	11	of	of	IN
cord-272051-arz8r204	152	12	PIs	pis	NN
cord-272051-arz8r204	152	13	is	be	VBZ
cord-272051-arz8r204	152	14	not	not	RB
cord-272051-arz8r204	152	15	the	the	DT
cord-272051-arz8r204	152	16	consequence	consequence	NN
cord-272051-arz8r204	152	17	of	of	IN
cord-272051-arz8r204	152	18	impaired	impaired	JJ
cord-272051-arz8r204	152	19	attachment	attachment	NN
cord-272051-arz8r204	152	20	and	and	CC
cord-272051-arz8r204	152	21	endocytosis	endocytosis	NN
cord-272051-arz8r204	152	22	of	of	IN
cord-272051-arz8r204	152	23	viral	viral	JJ
cord-272051-arz8r204	152	24	particles	particle	NNS
cord-272051-arz8r204	152	25	.	.	.
cord-272051-arz8r204	153	1	Next	next	RB
cord-272051-arz8r204	153	2	,	,	,
cord-272051-arz8r204	153	3	the	the	DT
cord-272051-arz8r204	153	4	possibility	possibility	NN
cord-272051-arz8r204	153	5	that	that	IN
cord-272051-arz8r204	153	6	the	the	DT
cord-272051-arz8r204	153	7	inhibitory	inhibitory	JJ
cord-272051-arz8r204	153	8	effect	effect	NN
cord-272051-arz8r204	153	9	of	of	IN
cord-272051-arz8r204	153	10	PIs	pi	NNS
cord-272051-arz8r204	153	11	was	be	VBD
cord-272051-arz8r204	153	12	a	a	DT
cord-272051-arz8r204	153	13	consequence	consequence	NN
cord-272051-arz8r204	153	14	of	of	IN
cord-272051-arz8r204	153	15	a	a	DT
cord-272051-arz8r204	153	16	defect	defect	NN
cord-272051-arz8r204	153	17	in	in	IN
cord-272051-arz8r204	153	18	the	the	DT
cord-272051-arz8r204	153	19	endosome	endosome	NN
cord-272051-arz8r204	153	20	to	to	TO
cord-272051-arz8r204	153	21	cytoplasm	cytoplasm	VB
cord-272051-arz8r204	153	22	virus	virus	NN
cord-272051-arz8r204	153	23	delivery	delivery	NN
cord-272051-arz8r204	153	24	was	be	VBD
cord-272051-arz8r204	153	25	investigated	investigate	VBN
cord-272051-arz8r204	153	26	.	.	.
cord-272051-arz8r204	154	1	To	to	IN
cord-272051-arz8r204	154	2	this	this	DT
cord-272051-arz8r204	154	3	end	end	NN
cord-272051-arz8r204	154	4	,	,	,
cord-272051-arz8r204	154	5	the	the	DT
cord-272051-arz8r204	154	6	differences	difference	NNS
cord-272051-arz8r204	154	7	in	in	IN
cord-272051-arz8r204	154	8	the	the	DT
cord-272051-arz8r204	154	9	cell	cell	NN
cord-272051-arz8r204	154	10	-	-	HYPH
cord-272051-arz8r204	154	11	associated	associate	VBN
cord-272051-arz8r204	154	12	fluorescence	fluorescence	NN
cord-272051-arz8r204	154	13	levels	level	NNS
cord-272051-arz8r204	154	14	in	in	IN
cord-272051-arz8r204	154	15	cells	cell	NNS
cord-272051-arz8r204	154	16	internalizing	internalize	VBG
cord-272051-arz8r204	154	17	wt	wt	NN
cord-272051-arz8r204	154	18	or	or	CC
cord-272051-arz8r204	154	19	fd	fd	NNP
cord-272051-arz8r204	154	20	VSV	VSV	NNP
cord-272051-arz8r204	154	21	-	-	HYPH
cord-272051-arz8r204	154	22	G	G	NNP
cord-272051-arz8r204	154	23	pseudotyped	pseudotyped	NNS
cord-272051-arz8r204	155	1	Nef	Nef	NNP
cord-272051-arz8r204	155	2	G3C	G3C	NNS
cord-272051-arz8r204	155	3	-GFP	-gfp	DT
cord-272051-arz8r204	155	4	VLPs	vlp	NNS
cord-272051-arz8r204	155	5	were	be	VBD
cord-272051-arz8r204	155	6	exploited	exploit	VBN
cord-272051-arz8r204	155	7	.	.	.
cord-272051-arz8r204	156	1	In	in	IN
cord-272051-arz8r204	156	2	fact	fact	NN
cord-272051-arz8r204	156	3	,	,	,
cord-272051-arz8r204	156	4	using	use	VBG
cord-272051-arz8r204	156	5	the	the	DT
cord-272051-arz8r204	156	6	same	same	JJ
cord-272051-arz8r204	156	7	experimental	experimental	JJ
cord-272051-arz8r204	156	8	conditions	condition	NNS
cord-272051-arz8r204	156	9	described	describe	VBN
cord-272051-arz8r204	156	10	for	for	IN
cord-272051-arz8r204	156	11	the	the	DT
cord-272051-arz8r204	156	12	endocytosis	endocytosis	NN
cord-272051-arz8r204	156	13	assay	assay	NN
cord-272051-arz8r204	156	14	,	,	,
cord-272051-arz8r204	156	15	it	-PRON-	PRP
cord-272051-arz8r204	156	16	was	be	VBD
cord-272051-arz8r204	156	17	reproducibly	reproducibly	RB
cord-272051-arz8r204	156	18	observed	observe	VBN
cord-272051-arz8r204	156	19	that	that	IN
cord-272051-arz8r204	156	20	,	,	,
cord-272051-arz8r204	156	21	early	early	RB
cord-272051-arz8r204	156	22	after	after	IN
cord-272051-arz8r204	156	23	VLP	VLP	NNP
cord-272051-arz8r204	156	24	challenge	challenge	NN
cord-272051-arz8r204	156	25	,	,	,
cord-272051-arz8r204	156	26	the	the	DT
cord-272051-arz8r204	156	27	mean	mean	JJ
cord-272051-arz8r204	156	28	fluorescence	fluorescence	NN
cord-272051-arz8r204	156	29	intensity	intensity	NN
cord-272051-arz8r204	156	30	(	(	-LRB-
cord-272051-arz8r204	156	31	MFI	MFI	NNP
cord-272051-arz8r204	156	32	)	)	-RRB-
cord-272051-arz8r204	156	33	of	of	IN
cord-272051-arz8r204	156	34	cells	cell	NNS
cord-272051-arz8r204	156	35	challenged	challenge	VBN
cord-272051-arz8r204	156	36	with	with	IN
cord-272051-arz8r204	156	37	(	(	-LRB-
cord-272051-arz8r204	156	38	wt	wt	NN
cord-272051-arz8r204	156	39	VSV	VSV	NNP
cord-272051-arz8r204	156	40	-	-	HYPH
cord-272051-arz8r204	156	41	G	G	NNP
cord-272051-arz8r204	156	42	)	)	-RRB-
cord-272051-arz8r204	156	43	VLPs	vlps	NN
cord-272051-arz8r204	156	44	was	be	VBD
cord-272051-arz8r204	156	45	near	near	IN
cord-272051-arz8r204	156	46	2-fold	2-fold	CD
cord-272051-arz8r204	156	47	higher	high	JJR
cord-272051-arz8r204	156	48	than	than	IN
cord-272051-arz8r204	156	49	that	that	DT
cord-272051-arz8r204	156	50	of	of	IN
cord-272051-arz8r204	156	51	cells	cell	NNS
cord-272051-arz8r204	156	52	treated	treat	VBN
cord-272051-arz8r204	156	53	with	with	IN
cord-272051-arz8r204	156	54	(	(	-LRB-
cord-272051-arz8r204	156	55	fd	fd	NNP
cord-272051-arz8r204	156	56	VSV	VSV	NNP
cord-272051-arz8r204	156	57	-	-	HYPH
cord-272051-arz8r204	156	58	G	G	NNP
cord-272051-arz8r204	156	59	)	)	-RRB-
cord-272051-arz8r204	156	60	VLPs	vlp	NNS
cord-272051-arz8r204	156	61	.	.	.
cord-272051-arz8r204	157	1	More	more	RBR
cord-272051-arz8r204	157	2	significantly	significantly	RB
cord-272051-arz8r204	157	3	,	,	,
cord-272051-arz8r204	157	4	in	in	IN
cord-272051-arz8r204	157	5	the	the	DT
cord-272051-arz8r204	157	6	latter	latter	JJ
cord-272051-arz8r204	157	7	condition	condition	NN
cord-272051-arz8r204	157	8	both	both	DT
cord-272051-arz8r204	157	9	percentages	percentage	NNS
cord-272051-arz8r204	157	10	of	of	IN
cord-272051-arz8r204	157	11	fluorescent	fluorescent	NN
cord-272051-arz8r204	157	12	cells	cell	NNS
cord-272051-arz8r204	157	13	and	and	CC
cord-272051-arz8r204	157	14	MFI	MFI	NNP
cord-272051-arz8r204	157	15	heavily	heavily	RB
cord-272051-arz8r204	157	16	dropped	drop	VBD
cord-272051-arz8r204	157	17	16	16	CD
cord-272051-arz8r204	157	18	h	h	NN
cord-272051-arz8r204	157	19	after	after	IN
cord-272051-arz8r204	157	20	challenge	challenge	NN
cord-272051-arz8r204	157	21	.	.	.
cord-272051-arz8r204	158	1	On	on	IN
cord-272051-arz8r204	158	2	the	the	DT
cord-272051-arz8r204	158	3	contrary	contrary	NN
cord-272051-arz8r204	158	4	,	,	,
cord-272051-arz8r204	158	5	both	both	DT
cord-272051-arz8r204	158	6	FACS	FACS	NNP
cord-272051-arz8r204	158	7	parameters	parameter	NNS
cord-272051-arz8r204	158	8	appeared	appear	VBD
cord-272051-arz8r204	158	9	only	only	RB
cord-272051-arz8r204	158	10	slightly	slightly	RB
cord-272051-arz8r204	158	11	reduced	reduce	VBN
cord-272051-arz8r204	158	12	in	in	IN
cord-272051-arz8r204	158	13	cells	cell	NNS
cord-272051-arz8r204	158	14	challenged	challenge	VBN
cord-272051-arz8r204	158	15	with	with	IN
cord-272051-arz8r204	158	16	(	(	-LRB-
cord-272051-arz8r204	158	17	wt	wt	NN
cord-272051-arz8r204	158	18	VSV	VSV	NNP
cord-272051-arz8r204	158	19	-	-	HYPH
cord-272051-arz8r204	158	20	G	G	NNP
cord-272051-arz8r204	158	21	)	)	-RRB-
cord-272051-arz8r204	158	22	VLPs	vlp	NNS
cord-272051-arz8r204	158	23	(	(	-LRB-
cord-272051-arz8r204	158	24	Fig	Fig	NNP
cord-272051-arz8r204	158	25	.	.	.
cord-272051-arz8r204	158	26	7A	7a	NN
cord-272051-arz8r204	158	27	)	)	-RRB-
cord-272051-arz8r204	158	28	.	.	.
cord-272051-arz8r204	159	1	These	these	DT
cord-272051-arz8r204	159	2	differences	difference	NNS
cord-272051-arz8r204	159	3	can	can	MD
cord-272051-arz8r204	159	4	be	be	VB
cord-272051-arz8r204	159	5	explained	explain	VBN
cord-272051-arz8r204	159	6	by	by	IN
cord-272051-arz8r204	159	7	the	the	DT
cord-272051-arz8r204	159	8	fact	fact	NN
cord-272051-arz8r204	159	9	that	that	IN
cord-272051-arz8r204	159	10	,	,	,
cord-272051-arz8r204	159	11	due	due	IN
cord-272051-arz8r204	159	12	to	to	IN
cord-272051-arz8r204	159	13	the	the	DT
cord-272051-arz8r204	159	14	inability	inability	NN
cord-272051-arz8r204	159	15	of	of	IN
cord-272051-arz8r204	159	16	fd	fd	NNP
cord-272051-arz8r204	159	17	VSV	VSV	NNP
cord-272051-arz8r204	159	18	-	-	HYPH
cord-272051-arz8r204	159	19	G	G	NNP
cord-272051-arz8r204	159	20	to	to	TO
cord-272051-arz8r204	159	21	induce	induce	VB
cord-272051-arz8r204	159	22	fusion	fusion	NN
cord-272051-arz8r204	159	23	and	and	CC
cord-272051-arz8r204	159	24	delivery	delivery	NN
cord-272051-arz8r204	159	25	of	of	IN
cord-272051-arz8r204	159	26	the	the	DT
cord-272051-arz8r204	159	27	VLP	VLP	NNP
cord-272051-arz8r204	159	28	contents	content	NNS
cord-272051-arz8r204	159	29	into	into	IN
cord-272051-arz8r204	159	30	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	159	31	,	,	,
cord-272051-arz8r204	159	32	the	the	DT
cord-272051-arz8r204	159	33	Nef	Nef	NNP
cord-272051-arz8r204	159	34	G3C	G3C	NNS
cord-272051-arz8r204	159	35	-GFP	-GFP	HYPH
cord-272051-arz8r204	159	36	molecules	molecule	NNS
cord-272051-arz8r204	159	37	incorporated	incorporate	VBN
cord-272051-arz8r204	159	38	in	in	IN
cord-272051-arz8r204	159	39	(	(	-LRB-
cord-272051-arz8r204	159	40	fd	fd	NNP
cord-272051-arz8r204	159	41	VSV	VSV	NNP
cord-272051-arz8r204	159	42	-	-	HYPH
cord-272051-arz8r204	159	43	G	G	NNP
cord-272051-arz8r204	159	44	)	)	-RRB-
cord-272051-arz8r204	159	45	VLPs	vlp	NNS
cord-272051-arz8r204	159	46	were	be	VBD
cord-272051-arz8r204	159	47	addressed	address	VBN
cord-272051-arz8r204	159	48	to	to	IN
cord-272051-arz8r204	159	49	rapid	rapid	JJ
cord-272051-arz8r204	159	50	degradation	degradation	NN
cord-272051-arz8r204	159	51	into	into	IN
cord-272051-arz8r204	159	52	the	the	DT
cord-272051-arz8r204	159	53	endosomal	endosomal	NNP
cord-272051-arz8r204	159	54	/	/	SYM
cord-272051-arz8r204	159	55	lysosomal	lysosomal	JJ
cord-272051-arz8r204	159	56	compartment	compartment	NN
cord-272051-arz8r204	159	57	.	.	.
cord-272051-arz8r204	160	1	Conversely	conversely	RB
cord-272051-arz8r204	160	2	,	,	,
cord-272051-arz8r204	160	3	the	the	DT
cord-272051-arz8r204	160	4	efficient	efficient	JJ
cord-272051-arz8r204	160	5	fusion	fusion	NN
cord-272051-arz8r204	160	6	between	between	IN
cord-272051-arz8r204	160	7	viral	viral	JJ
cord-272051-arz8r204	160	8	envelope	envelope	NN
cord-272051-arz8r204	160	9	and	and	CC
cord-272051-arz8r204	160	10	endosome	endosome	NN
cord-272051-arz8r204	160	11	membranes	membrane	NNS
cord-272051-arz8r204	160	12	induced	induce	VBN
cord-272051-arz8r204	160	13	by	by	IN
cord-272051-arz8r204	160	14	wt	wt	NN
cord-272051-arz8r204	160	15	VSV	VSV	NNP
cord-272051-arz8r204	160	16	-	-	HYPH
cord-272051-arz8r204	160	17	G	G	NNP
cord-272051-arz8r204	160	18	allowed	allow	VBD
cord-272051-arz8r204	160	19	the	the	DT
cord-272051-arz8r204	160	20	release	release	NN
cord-272051-arz8r204	160	21	of	of	IN
cord-272051-arz8r204	160	22	Nef	Nef	NNP
cord-272051-arz8r204	160	23	G3C	G3C	NNS
cord-272051-arz8r204	160	24	-GFP	-gfp	POS
cord-272051-arz8r204	160	25	molecules	molecule	NNS
cord-272051-arz8r204	160	26	into	into	IN
cord-272051-arz8r204	160	27	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	160	28	,	,	,
cord-272051-arz8r204	160	29	where	where	WRB
cord-272051-arz8r204	160	30	they	-PRON-	PRP
cord-272051-arz8r204	160	31	are	be	VBP
cord-272051-arz8r204	160	32	expected	expect	VBN
cord-272051-arz8r204	160	33	to	to	TO
cord-272051-arz8r204	160	34	be	be	VB
cord-272051-arz8r204	160	35	degraded	degrade	VBN
cord-272051-arz8r204	160	36	with	with	IN
cord-272051-arz8r204	160	37	a	a	DT
cord-272051-arz8r204	160	38	kinetic	kinetic	NN
cord-272051-arz8r204	160	39	much	much	RB
cord-272051-arz8r204	160	40	slower	slow	JJR
cord-272051-arz8r204	160	41	than	than	IN
cord-272051-arz8r204	160	42	that	that	DT
cord-272051-arz8r204	160	43	operating	operate	VBG
cord-272051-arz8r204	160	44	in	in	IN
cord-272051-arz8r204	160	45	endosomes	endosome	NNS
cord-272051-arz8r204	160	46	/	/	SYM
cord-272051-arz8r204	160	47	lysosomes	lysosome	NNS
cord-272051-arz8r204	160	48	.	.	.
cord-272051-arz8r204	161	1	Next	next	RB
cord-272051-arz8r204	161	2	,	,	,
cord-272051-arz8r204	161	3	PI	PI	NNP
cord-272051-arz8r204	161	4	-	-	HYPH
cord-272051-arz8r204	161	5	treated	treat	VBN
cord-272051-arz8r204	161	6	or	or	CC
cord-272051-arz8r204	161	7	untreated	untreated	JJ
cord-272051-arz8r204	161	8	HeLa	HeLa	NNP
cord-272051-arz8r204	161	9	cells	cell	NNS
cord-272051-arz8r204	161	10	were	be	VBD
cord-272051-arz8r204	161	11	challenged	challenge	VBN
cord-272051-arz8r204	161	12	with	with	IN
cord-272051-arz8r204	161	13	500	500	CD
cord-272051-arz8r204	161	14	ng	ng	NNP
cord-272051-arz8r204	161	15	HIV-1	HIV-1	NNP
cord-272051-arz8r204	161	16	CAp24	CAp24	VBZ
cord-272051-arz8r204	161	17	equivalent	equivalent	JJ
cord-272051-arz8r204	161	18	of	of	IN
cord-272051-arz8r204	161	19	either	either	DT
cord-272051-arz8r204	161	20	(	(	-LRB-
cord-272051-arz8r204	161	21	wt	wt	NNP
cord-272051-arz8r204	161	22	VSV	VSV	NNP
cord-272051-arz8r204	161	23	-	-	HYPH
cord-272051-arz8r204	161	24	G	G	NNP
cord-272051-arz8r204	161	25	)	)	-RRB-
cord-272051-arz8r204	161	26	or	or	CC
cord-272051-arz8r204	161	27	(	(	-LRB-
cord-272051-arz8r204	161	28	fd	fd	NNP
cord-272051-arz8r204	161	29	VSV	VSV	NNP
cord-272051-arz8r204	161	30	-	-	HYPH
cord-272051-arz8r204	161	31	G	G	NNP
cord-272051-arz8r204	161	32	)	)	-RRB-
cord-272051-arz8r204	162	1	Nef	Nef	NNP
cord-272051-arz8r204	163	1	G3C	g3c	LS
cord-272051-arz8r204	163	2	-GFP	-gfp	ADD
cord-272051-arz8r204	164	1	VLPs/10	VLPs/10	NNP
cord-272051-arz8r204	164	2	5	5	CD
cord-272051-arz8r204	164	3	cells	cell	NNS
cord-272051-arz8r204	164	4	,	,	,
cord-272051-arz8r204	164	5	and	and	CC
cord-272051-arz8r204	164	6	3	3	CD
cord-272051-arz8r204	164	7	and	and	CC
cord-272051-arz8r204	164	8	16	16	CD
cord-272051-arz8r204	164	9	h	h	NN
cord-272051-arz8r204	164	10	later	later	RB
cord-272051-arz8r204	164	11	,	,	,
cord-272051-arz8r204	164	12	the	the	DT
cord-272051-arz8r204	164	13	cells	cell	NNS
cord-272051-arz8r204	164	14	were	be	VBD
cord-272051-arz8r204	164	15	treated	treat	VBN
cord-272051-arz8r204	164	16	with	with	IN
cord-272051-arz8r204	164	17	trypsin	trypsin	NN
cord-272051-arz8r204	164	18	.	.	.
cord-272051-arz8r204	165	1	FACS	FACS	NNP
cord-272051-arz8r204	165	2	analysis	analysis	NN
cord-272051-arz8r204	165	3	of	of	IN
cord-272051-arz8r204	165	4	the	the	DT
cord-272051-arz8r204	165	5	cell	cell	NN
cord-272051-arz8r204	165	6	-	-	HYPH
cord-272051-arz8r204	165	7	associated	associate	VBN
cord-272051-arz8r204	165	8	GFP	GFP	NNP
cord-272051-arz8r204	165	9	fluorescence	fluorescence	NN
cord-272051-arz8r204	165	10	revealed	reveal	VBD
cord-272051-arz8r204	165	11	that	that	IN
cord-272051-arz8r204	165	12	the	the	DT
cord-272051-arz8r204	165	13	PI	PI	NNP
cord-272051-arz8r204	165	14	treatment	treatment	NN
cord-272051-arz8r204	165	15	did	do	VBD
cord-272051-arz8r204	165	16	not	not	RB
cord-272051-arz8r204	165	17	affect	affect	VB
cord-272051-arz8r204	165	18	the	the	DT
cord-272051-arz8r204	165	19	fluorescence	fluorescence	NN
cord-272051-arz8r204	165	20	levels	level	NNS
cord-272051-arz8r204	165	21	in	in	IN
cord-272051-arz8r204	165	22	cells	cell	NNS
cord-272051-arz8r204	165	23	challenged	challenge	VBN
cord-272051-arz8r204	165	24	with	with	IN
cord-272051-arz8r204	166	1	(	(	-LRB-
cord-272051-arz8r204	166	2	fd	fd	NNP
cord-272051-arz8r204	166	3	VSV	VSV	NNP
cord-272051-arz8r204	166	4	-	-	HYPH
cord-272051-arz8r204	166	5	G	G	NNP
cord-272051-arz8r204	166	6	)	)	-RRB-
cord-272051-arz8r204	166	7	Nef	Nef	NNP
cord-272051-arz8r204	166	8	G3C	G3C	NNS
cord-272051-arz8r204	167	1	-GFP	-GFP	NFP
cord-272051-arz8r204	167	2	VLPs	vlp	NNS
cord-272051-arz8r204	167	3	at	at	IN
cord-272051-arz8r204	167	4	both	both	DT
cord-272051-arz8r204	167	5	time	time	NN
cord-272051-arz8r204	167	6	points	point	NNS
cord-272051-arz8r204	167	7	.	.	.
cord-272051-arz8r204	168	1	On	on	IN
cord-272051-arz8r204	168	2	the	the	DT
cord-272051-arz8r204	168	3	contrary	contrary	NN
cord-272051-arz8r204	168	4	,	,	,
cord-272051-arz8r204	168	5	after	after	IN
cord-272051-arz8r204	168	6	3	3	CD
cord-272051-arz8r204	168	7	h	h	NN
cord-272051-arz8r204	168	8	it	-PRON-	PRP
cord-272051-arz8r204	168	9	was	be	VBD
cord-272051-arz8r204	168	10	observed	observe	VBN
cord-272051-arz8r204	168	11	a	a	DT
cord-272051-arz8r204	168	12	relevant	relevant	JJ
cord-272051-arz8r204	168	13	reduction	reduction	NN
cord-272051-arz8r204	168	14	in	in	IN
cord-272051-arz8r204	168	15	the	the	DT
cord-272051-arz8r204	168	16	MFI	MFI	NNP
cord-272051-arz8r204	168	17	within	within	IN
cord-272051-arz8r204	168	18	PI	pi	NN
cord-272051-arz8r204	168	19	-	-	HYPH
cord-272051-arz8r204	168	20	treated	treat	VBN
cord-272051-arz8r204	168	21	cells	cell	NNS
cord-272051-arz8r204	168	22	challenged	challenge	VBN
cord-272051-arz8r204	168	23	with	with	IN
cord-272051-arz8r204	168	24	(	(	-LRB-
cord-272051-arz8r204	168	25	wt	wt	NN
cord-272051-arz8r204	168	26	VSV	VSV	NNP
cord-272051-arz8r204	168	27	-	-	HYPH
cord-272051-arz8r204	168	28	G	G	NNP
cord-272051-arz8r204	168	29	)	)	-RRB-
cord-272051-arz8r204	168	30	Nef	Nef	NNP
cord-272051-arz8r204	168	31	G3C	G3C	NNS
cord-272051-arz8r204	168	32	-GFP	-gfp	DT
cord-272051-arz8r204	168	33	VLPs	vlp	NNS
cord-272051-arz8r204	168	34	as	as	IN
cord-272051-arz8r204	168	35	compared	compare	VBN
cord-272051-arz8r204	168	36	with	with	IN
cord-272051-arz8r204	168	37	untreated	untreated	JJ
cord-272051-arz8r204	168	38	cells	cell	NNS
cord-272051-arz8r204	168	39	.	.	.
cord-272051-arz8r204	169	1	More	more	RBR
cord-272051-arz8r204	169	2	strikingly	strikingly	RB
cord-272051-arz8r204	169	3	,	,	,
cord-272051-arz8r204	169	4	a	a	DT
cord-272051-arz8r204	169	5	strong	strong	JJ
cord-272051-arz8r204	169	6	decrease	decrease	NN
cord-272051-arz8r204	169	7	of	of	IN
cord-272051-arz8r204	169	8	both	both	DT
cord-272051-arz8r204	169	9	MFI	MFI	NNP
cord-272051-arz8r204	169	10	and	and	CC
cord-272051-arz8r204	169	11	percentage	percentage	NN
cord-272051-arz8r204	169	12	of	of	IN
cord-272051-arz8r204	169	13	fluorescent	fluorescent	NN
cord-272051-arz8r204	169	14	cells	cell	NNS
cord-272051-arz8r204	169	15	was	be	VBD
cord-272051-arz8r204	169	16	detectable	detectable	JJ
cord-272051-arz8r204	169	17	in	in	IN
cord-272051-arz8r204	169	18	PI	pi	NN
cord-272051-arz8r204	169	19	-	-	HYPH
cord-272051-arz8r204	169	20	treated	treat	VBN
cord-272051-arz8r204	169	21	cells	cell	NNS
cord-272051-arz8r204	169	22	at	at	IN
cord-272051-arz8r204	169	23	16	16	CD
cord-272051-arz8r204	169	24	h	h	NN
cord-272051-arz8r204	169	25	post	post	JJ
cord-272051-arz8r204	169	26	-	-	JJ
cord-272051-arz8r204	169	27	challenge	challenge	NN
cord-272051-arz8r204	169	28	(	(	-LRB-
cord-272051-arz8r204	169	29	Fig	Fig	NNP
cord-272051-arz8r204	169	30	.	.	.
cord-272051-arz8r204	169	31	7B	7B	NNP
cord-272051-arz8r204	169	32	)	)	-RRB-
cord-272051-arz8r204	169	33	.	.	.
cord-272051-arz8r204	170	1	As	as	IN
cord-272051-arz8r204	170	2	expected	expect	VBN
cord-272051-arz8r204	170	3	,	,	,
cord-272051-arz8r204	170	4	among	among	IN
cord-272051-arz8r204	170	5	the	the	DT
cord-272051-arz8r204	170	6	different	different	JJ
cord-272051-arz8r204	170	7	PI	pi	NN
cord-272051-arz8r204	170	8	tested	test	VBN
cord-272051-arz8r204	170	9	,	,	,
cord-272051-arz8r204	170	10	saquinavir	saquinavir	NNP
cord-272051-arz8r204	170	11	and	and	CC
cord-272051-arz8r204	170	12	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	170	13	produced	produce	VBD
cord-272051-arz8r204	170	14	the	the	DT
cord-272051-arz8r204	170	15	strongest	strong	JJS
cord-272051-arz8r204	170	16	inhibitory	inhibitory	JJ
cord-272051-arz8r204	170	17	effect	effect	NN
cord-272051-arz8r204	170	18	(	(	-LRB-
cord-272051-arz8r204	170	19	data	datum	NNS
cord-272051-arz8r204	170	20	not	not	RB
cord-272051-arz8r204	170	21	shown	show	VBN
cord-272051-arz8r204	170	22	)	)	-RRB-
cord-272051-arz8r204	170	23	.	.	.
cord-272051-arz8r204	171	1	Next	next	RB
cord-272051-arz8r204	171	2	,	,	,
cord-272051-arz8r204	171	3	dose	dose	NN
cord-272051-arz8r204	171	4	-	-	HYPH
cord-272051-arz8r204	171	5	response	response	NN
cord-272051-arz8r204	171	6	endocytosis	endocytosis	NN
cord-272051-arz8r204	171	7	assays	assay	NNS
cord-272051-arz8r204	171	8	using	use	VBG
cord-272051-arz8r204	171	9	different	different	JJ
cord-272051-arz8r204	171	10	concentrations	concentration	NNS
cord-272051-arz8r204	171	11	of	of	IN
cord-272051-arz8r204	171	12	nelfinavir	nelfinavir	NNS
cord-272051-arz8r204	171	13	were	be	VBD
cord-272051-arz8r204	171	14	carried	carry	VBN
cord-272051-arz8r204	171	15	out	out	RP
cord-272051-arz8r204	171	16	by	by	IN
cord-272051-arz8r204	171	17	analyzing	analyze	VBG
cord-272051-arz8r204	171	18	the	the	DT
cord-272051-arz8r204	171	19	cell	cell	NN
cord-272051-arz8r204	171	20	-	-	HYPH
cord-272051-arz8r204	171	21	associated	associate	VBN
cord-272051-arz8r204	171	22	fluorescence	fluorescence	NN
cord-272051-arz8r204	171	23	16	16	CD
cord-272051-arz8r204	171	24	h	h	NN
cord-272051-arz8r204	171	25	after	after	IN
cord-272051-arz8r204	171	26	the	the	DT
cord-272051-arz8r204	171	27	challenge	challenge	NN
cord-272051-arz8r204	171	28	.	.	.
cord-272051-arz8r204	172	1	The	the	DT
cord-272051-arz8r204	172	2	results	result	NNS
cord-272051-arz8r204	172	3	showed	show	VBD
cord-272051-arz8r204	172	4	that	that	IN
cord-272051-arz8r204	172	5	,	,	,
cord-272051-arz8r204	172	6	within	within	IN
cord-272051-arz8r204	172	7	the	the	DT
cord-272051-arz8r204	172	8	cells	cell	NNS
cord-272051-arz8r204	172	9	challenged	challenge	VBN
cord-272051-arz8r204	172	10	with	with	IN
cord-272051-arz8r204	173	1	(	(	-LRB-
cord-272051-arz8r204	173	2	wt	wt	NNP
cord-272051-arz8r204	173	3	VSV	VSV	NNP
cord-272051-arz8r204	173	4	-	-	HYPH
cord-272051-arz8r204	173	5	G	G	NNP
cord-272051-arz8r204	173	6	)	)	-RRB-
cord-272051-arz8r204	173	7	Nef	Nef	NNP
cord-272051-arz8r204	173	8	G3C	G3C	NNS
cord-272051-arz8r204	173	9	-GFP	-gfp	DT
cord-272051-arz8r204	173	10	VLPs	vlp	NNS
cord-272051-arz8r204	173	11	,	,	,
cord-272051-arz8r204	173	12	the	the	DT
cord-272051-arz8r204	173	13	PI	PI	NNP
cord-272051-arz8r204	173	14	treatment	treatment	NN
cord-272051-arz8r204	173	15	reduced	reduce	VBD
cord-272051-arz8r204	173	16	both	both	CC
cord-272051-arz8r204	173	17	MFI	MFI	NNP
cord-272051-arz8r204	173	18	and	and	CC
cord-272051-arz8r204	173	19	percentages	percentage	NNS
cord-272051-arz8r204	173	20	of	of	IN
cord-272051-arz8r204	173	21	fluorescent	fluorescent	NN
cord-272051-arz8r204	173	22	cells	cell	NNS
cord-272051-arz8r204	173	23	in	in	IN
cord-272051-arz8r204	173	24	a	a	DT
cord-272051-arz8r204	173	25	dose	dose	NN
cord-272051-arz8r204	173	26	-	-	HYPH
cord-272051-arz8r204	173	27	dependent	dependent	JJ
cord-272051-arz8r204	173	28	manner	manner	NN
cord-272051-arz8r204	173	29	.	.	.
cord-272051-arz8r204	174	1	At	at	IN
cord-272051-arz8r204	174	2	the	the	DT
cord-272051-arz8r204	174	3	highest	high	JJS
cord-272051-arz8r204	174	4	PI	pi	NN
cord-272051-arz8r204	174	5	concentrations	concentration	NNS
cord-272051-arz8r204	174	6	,	,	,
cord-272051-arz8r204	174	7	both	both	DT
cord-272051-arz8r204	174	8	parameters	parameter	NNS
cord-272051-arz8r204	174	9	reached	reach	VBD
cord-272051-arz8r204	174	10	levels	level	NNS
cord-272051-arz8r204	174	11	similar	similar	JJ
cord-272051-arz8r204	174	12	to	to	IN
cord-272051-arz8r204	174	13	those	those	DT
cord-272051-arz8r204	174	14	detectable	detectable	JJ
cord-272051-arz8r204	174	15	in	in	IN
cord-272051-arz8r204	174	16	cells	cell	NNS
cord-272051-arz8r204	174	17	challenged	challenge	VBN
cord-272051-arz8r204	174	18	with	with	IN
cord-272051-arz8r204	175	1	(	(	-LRB-
cord-272051-arz8r204	175	2	fd	fd	NNP
cord-272051-arz8r204	175	3	-	-	HYPH
cord-272051-arz8r204	175	4	VSV	VSV	NNP
cord-272051-arz8r204	175	5	-	-	HYPH
cord-272051-arz8r204	175	6	G	G	NNP
cord-272051-arz8r204	175	7	)	)	-RRB-
cord-272051-arz8r204	175	8	Nef	Nef	NNP
cord-272051-arz8r204	175	9	G3C	G3C	NNS
cord-272051-arz8r204	176	1	-GFP	-GFP	:
cord-272051-arz8r204	176	2	VLPs	VLPs	NNP
cord-272051-arz8r204	176	3	(	(	-LRB-
cord-272051-arz8r204	176	4	Fig	Fig	NNP
cord-272051-arz8r204	176	5	.	.	.
cord-272051-arz8r204	176	6	7C	7C	NNP
cord-272051-arz8r204	176	7	)	)	-RRB-
cord-272051-arz8r204	176	8	.	.	.
cord-272051-arz8r204	177	1	Hence	hence	RB
cord-272051-arz8r204	177	2	,	,	,
cord-272051-arz8r204	177	3	it	-PRON-	PRP
cord-272051-arz8r204	177	4	seemed	seem	VBD
cord-272051-arz8r204	177	5	that	that	IN
cord-272051-arz8r204	177	6	the	the	DT
cord-272051-arz8r204	177	7	PI	PI	NNP
cord-272051-arz8r204	177	8	treatment	treatment	NN
cord-272051-arz8r204	177	9	diverted	divert	VBD
cord-272051-arz8r204	177	10	the	the	DT
cord-272051-arz8r204	177	11	fate	fate	NN
cord-272051-arz8r204	177	12	of	of	IN
cord-272051-arz8r204	177	13	endocytosed	endocytosed	NNP
cord-272051-arz8r204	177	14	(	(	-LRB-
cord-272051-arz8r204	177	15	wt	wt	NNP
cord-272051-arz8r204	177	16	VSV	VSV	NNP
cord-272051-arz8r204	177	17	-	-	HYPH
cord-272051-arz8r204	177	18	G	G	NNP
cord-272051-arz8r204	177	19	)	)	-RRB-
cord-272051-arz8r204	177	20	towards	towards	IN
cord-272051-arz8r204	177	21	that	that	DT
cord-272051-arz8r204	177	22	of	of	IN
cord-272051-arz8r204	177	23	(	(	-LRB-
cord-272051-arz8r204	177	24	fd	fd	NNP
cord-272051-arz8r204	177	25	VSV	VSV	NNP
cord-272051-arz8r204	177	26	-	-	HYPH
cord-272051-arz8r204	177	27	G	G	NNP
cord-272051-arz8r204	177	28	)	)	-RRB-
cord-272051-arz8r204	177	29	VLPs	vlp	NNS
cord-272051-arz8r204	177	30	.	.	.
cord-272051-arz8r204	178	1	This	this	DT
cord-272051-arz8r204	178	2	strongly	strongly	RB
cord-272051-arz8r204	178	3	suggests	suggest	VBZ
cord-272051-arz8r204	178	4	that	that	IN
cord-272051-arz8r204	178	5	PIs	pi	NNS
cord-272051-arz8r204	178	6	negatively	negatively	RB
cord-272051-arz8r204	178	7	affect	affect	VBP
cord-272051-arz8r204	178	8	the	the	DT
cord-272051-arz8r204	178	9	fusion	fusion	NN
cord-272051-arz8r204	178	10	of	of	IN
cord-272051-arz8r204	178	11	viral	viral	JJ
cord-272051-arz8r204	178	12	envelope	envelope	NN
cord-272051-arz8r204	178	13	with	with	IN
cord-272051-arz8r204	178	14	the	the	DT
cord-272051-arz8r204	178	15	endosomal	endosomal	NNP
cord-272051-arz8r204	178	16	membranes	membrane	NNS
cord-272051-arz8r204	178	17	.	.	.
cord-272051-arz8r204	179	1	Together	together	RB
cord-272051-arz8r204	179	2	,	,	,
cord-272051-arz8r204	179	3	these	these	DT
cord-272051-arz8r204	179	4	results	result	NNS
cord-272051-arz8r204	179	5	support	support	VBP
cord-272051-arz8r204	179	6	the	the	DT
cord-272051-arz8r204	179	7	idea	idea	NN
cord-272051-arz8r204	179	8	that	that	IN
cord-272051-arz8r204	179	9	the	the	DT
cord-272051-arz8r204	179	10	inhibitory	inhibitory	JJ
cord-272051-arz8r204	179	11	effect	effect	NN
cord-272051-arz8r204	179	12	of	of	IN
cord-272051-arz8r204	179	13	PIs	pi	NNS
cord-272051-arz8r204	179	14	acts	act	VBZ
cord-272051-arz8r204	179	15	at	at	IN
cord-272051-arz8r204	179	16	the	the	DT
cord-272051-arz8r204	179	17	level	level	NN
cord-272051-arz8r204	179	18	of	of	IN
cord-272051-arz8r204	179	19	the	the	DT
cord-272051-arz8r204	179	20	delivery	delivery	NN
cord-272051-arz8r204	179	21	of	of	IN
cord-272051-arz8r204	179	22	the	the	DT
cord-272051-arz8r204	179	23	viral	viral	JJ
cord-272051-arz8r204	179	24	particles	particle	NNS
cord-272051-arz8r204	179	25	from	from	IN
cord-272051-arz8r204	179	26	endosomes	endosome	NNS
cord-272051-arz8r204	179	27	to	to	IN
cord-272051-arz8r204	179	28	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	179	29	of	of	IN
cord-272051-arz8r204	179	30	infected	infected	JJ
cord-272051-arz8r204	179	31	cells	cell	NNS
cord-272051-arz8r204	179	32	.	.	.
cord-272051-arz8r204	180	1	A	a	DT
cord-272051-arz8r204	180	2	possible	possible	JJ
cord-272051-arz8r204	180	3	explanation	explanation	NN
cord-272051-arz8r204	180	4	for	for	IN
cord-272051-arz8r204	180	5	the	the	DT
cord-272051-arz8r204	180	6	apparent	apparent	JJ
cord-272051-arz8r204	180	7	block	block	NN
cord-272051-arz8r204	180	8	of	of	IN
cord-272051-arz8r204	180	9	viral	viral	JJ
cord-272051-arz8r204	180	10	envelope	envelope	NN
cord-272051-arz8r204	180	11	fusion	fusion	NN
cord-272051-arz8r204	180	12	could	could	MD
cord-272051-arz8r204	180	13	be	be	VB
cord-272051-arz8r204	180	14	that	that	IN
cord-272051-arz8r204	180	15	PIs	pi	NNS
cord-272051-arz8r204	180	16	may	may	MD
cord-272051-arz8r204	180	17	increase	increase	VB
cord-272051-arz8r204	180	18	the	the	DT
cord-272051-arz8r204	180	19	pH	ph	NN
cord-272051-arz8r204	180	20	in	in	IN
cord-272051-arz8r204	180	21	endosomes	endosome	NNS
cord-272051-arz8r204	180	22	in	in	IN
cord-272051-arz8r204	180	23	a	a	DT
cord-272051-arz8r204	180	24	way	way	NN
cord-272051-arz8r204	180	25	to	to	TO
cord-272051-arz8r204	180	26	inhibit	inhibit	VB
cord-272051-arz8r204	180	27	the	the	DT
cord-272051-arz8r204	180	28	low	low	JJ
cord-272051-arz8r204	180	29	pH	ph	NN
cord-272051-arz8r204	180	30	-	-	HYPH
cord-272051-arz8r204	180	31	dependent	dependent	JJ
cord-272051-arz8r204	180	32	conformational	conformational	JJ
cord-272051-arz8r204	180	33	changes	change	NNS
cord-272051-arz8r204	180	34	needed	need	VBN
cord-272051-arz8r204	180	35	for	for	IN
cord-272051-arz8r204	180	36	both	both	DT
cord-272051-arz8r204	180	37	VSV	VSV	NNP
cord-272051-arz8r204	180	38	-	-	HYPH
cord-272051-arz8r204	180	39	G	G	NNP
cord-272051-arz8r204	180	40	and	and	CC
cord-272051-arz8r204	180	41	influenza	influenza	NN
cord-272051-arz8r204	180	42	HA	HA	NNP
cord-272051-arz8r204	180	43	to	to	TO
cord-272051-arz8r204	180	44	switch	switch	VB
cord-272051-arz8r204	180	45	the	the	DT
cord-272051-arz8r204	180	46	fusion	fusion	NN
cord-272051-arz8r204	180	47	process	process	NN
cord-272051-arz8r204	180	48	.	.	.
cord-272051-arz8r204	181	1	To	to	TO
cord-272051-arz8r204	181	2	test	test	VB
cord-272051-arz8r204	181	3	whether	whether	IN
cord-272051-arz8r204	181	4	PIs	pi	NNS
cord-272051-arz8r204	181	5	affect	affect	VBP
cord-272051-arz8r204	181	6	intracellular	intracellular	JJ
cord-272051-arz8r204	181	7	pH	ph	NN
cord-272051-arz8r204	181	8	,	,	,
cord-272051-arz8r204	181	9	both	both	CC
cord-272051-arz8r204	181	10	HeLa	HeLa	NNP
cord-272051-arz8r204	181	11	and	and	CC
cord-272051-arz8r204	181	12	MDCK	MDCK	NNP
cord-272051-arz8r204	181	13	cells	cell	NNS
cord-272051-arz8r204	181	14	were	be	VBD
cord-272051-arz8r204	181	15	labeled	label	VBN
cord-272051-arz8r204	181	16	with	with	IN
cord-272051-arz8r204	181	17	LysoSensor	LysoSensor	NNP
cord-272051-arz8r204	181	18	Green	Green	NNP
cord-272051-arz8r204	181	19	DND-189	DND-189	NNP
cord-272051-arz8r204	181	20	.	.	.
cord-272051-arz8r204	182	1	This	this	DT
cord-272051-arz8r204	182	2	reagent	reagent	NN
cord-272051-arz8r204	182	3	becomes	become	VBZ
cord-272051-arz8r204	182	4	fluorescent	fluorescent	NN
cord-272051-arz8r204	182	5	only	only	RB
cord-272051-arz8r204	182	6	in	in	IN
cord-272051-arz8r204	182	7	acidic	acidic	JJ
cord-272051-arz8r204	182	8	intracellular	intracellular	JJ
cord-272051-arz8r204	182	9	compartments	compartment	NNS
cord-272051-arz8r204	182	10	,	,	,
cord-272051-arz8r204	182	11	meanwhile	meanwhile	RB
cord-272051-arz8r204	182	12	exhibiting	exhibit	VBG
cord-272051-arz8r204	182	13	decreased	decrease	VBN
cord-272051-arz8r204	182	14	fluorescence	fluorescence	NN
cord-272051-arz8r204	182	15	intensity	intensity	NN
cord-272051-arz8r204	182	16	upon	upon	IN
cord-272051-arz8r204	182	17	pH	pH	NNP
cord-272051-arz8r204	182	18	increase	increase	NN
cord-272051-arz8r204	182	19	.	.	.
cord-272051-arz8r204	183	1	Thus	thus	RB
cord-272051-arz8r204	183	2	,	,	,
cord-272051-arz8r204	183	3	it	-PRON-	PRP
cord-272051-arz8r204	183	4	represents	represent	VBZ
cord-272051-arz8r204	183	5	a	a	DT
cord-272051-arz8r204	183	6	useful	useful	JJ
cord-272051-arz8r204	183	7	reagent	reagent	NN
cord-272051-arz8r204	183	8	for	for	IN
cord-272051-arz8r204	183	9	detecting	detect	VBG
cord-272051-arz8r204	183	10	possible	possible	JJ
cord-272051-arz8r204	183	11	pH	pH	NNP
cord-272051-arz8r204	183	12	variations	variation	NNS
cord-272051-arz8r204	183	13	in	in	IN
cord-272051-arz8r204	183	14	endosomes	endosome	NNS
cord-272051-arz8r204	183	15	.	.	.
cord-272051-arz8r204	184	1	Cells	cell	NNS
cord-272051-arz8r204	184	2	were	be	VBD
cord-272051-arz8r204	184	3	treated	treat	VBN
cord-272051-arz8r204	184	4	overnight	overnight	RB
cord-272051-arz8r204	184	5	with	with	IN
cord-272051-arz8r204	184	6	the	the	DT
cord-272051-arz8r204	184	7	PI	PI	NNP
cord-272051-arz8r204	184	8	doses	dose	NNS
cord-272051-arz8r204	184	9	most	most	RBS
cord-272051-arz8r204	184	10	effective	effective	JJ
cord-272051-arz8r204	184	11	against	against	IN
cord-272051-arz8r204	184	12	VSV	VSV	NNP
cord-272051-arz8r204	184	13	and/or	and/or	CC
cord-272051-arz8r204	184	14	influenza	influenza	NN
cord-272051-arz8r204	184	15	virus	virus	NN
cord-272051-arz8r204	184	16	replication	replication	NN
cord-272051-arz8r204	184	17	,	,	,
cord-272051-arz8r204	184	18	then	then	RB
cord-272051-arz8r204	184	19	labeled	label	VBN
cord-272051-arz8r204	184	20	with	with	IN
cord-272051-arz8r204	184	21	LysoSensor	LysoSensor	NNP
cord-272051-arz8r204	184	22	Green	Green	NNP
cord-272051-arz8r204	184	23	DND-189	DND-189	NNP
cord-272051-arz8r204	184	24	for	for	IN
cord-272051-arz8r204	184	25	30	30	CD
cord-272051-arz8r204	184	26	min	min	NN
cord-272051-arz8r204	184	27	in	in	IN
cord-272051-arz8r204	184	28	the	the	DT
cord-272051-arz8r204	184	29	presence	presence	NN
cord-272051-arz8r204	184	30	of	of	IN
cord-272051-arz8r204	184	31	PIs	pi	NNS
cord-272051-arz8r204	184	32	,	,	,
cord-272051-arz8r204	184	33	and	and	CC
cord-272051-arz8r204	184	34	finally	finally	RB
cord-272051-arz8r204	184	35	analyzed	analyze	VBN
cord-272051-arz8r204	184	36	by	by	IN
cord-272051-arz8r204	184	37	FACS	FACS	NNP
cord-272051-arz8r204	184	38	.	.	.
cord-272051-arz8r204	185	1	As	as	IN
cord-272051-arz8r204	185	2	control	control	NN
cord-272051-arz8r204	185	3	,	,	,
cord-272051-arz8r204	185	4	cells	cell	NNS
cord-272051-arz8r204	185	5	treated	treat	VBN
cord-272051-arz8r204	185	6	with	with	IN
cord-272051-arz8r204	185	7	bafilomycin	bafilomycin	NNP
cord-272051-arz8r204	185	8	A1	A1	NNP
cord-272051-arz8r204	185	9	,	,	,
cord-272051-arz8r204	185	10	i.e.	i.e.	FW
cord-272051-arz8r204	185	11	,	,	,
cord-272051-arz8r204	185	12	a	a	DT
cord-272051-arz8r204	185	13	powerful	powerful	JJ
cord-272051-arz8r204	185	14	inhibitor	inhibitor	NN
cord-272051-arz8r204	185	15	of	of	IN
cord-272051-arz8r204	185	16	the	the	DT
cord-272051-arz8r204	185	17	vacuolar	vacuolar	NNP
cord-272051-arz8r204	186	1	ATPase	ATPase	NNP
cord-272051-arz8r204	186	2	proton	proton	NN
cord-272051-arz8r204	186	3	pump	pump	NN
cord-272051-arz8r204	186	4	,	,	,
cord-272051-arz8r204	186	5	were	be	VBD
cord-272051-arz8r204	186	6	also	also	RB
cord-272051-arz8r204	186	7	tested	test	VBN
cord-272051-arz8r204	186	8	.	.	.
cord-272051-arz8r204	187	1	As	as	IN
cord-272051-arz8r204	187	2	depicted	depict	VBN
cord-272051-arz8r204	187	3	in	in	IN
cord-272051-arz8r204	187	4	Fig	Fig	NNP
cord-272051-arz8r204	187	5	.	.	.
cord-272051-arz8r204	188	1	8	8	CD
cord-272051-arz8r204	188	2	,	,	,
cord-272051-arz8r204	188	3	no	no	DT
cord-272051-arz8r204	188	4	significant	significant	JJ
cord-272051-arz8r204	188	5	variations	variation	NNS
cord-272051-arz8r204	188	6	in	in	IN
cord-272051-arz8r204	188	7	the	the	DT
cord-272051-arz8r204	188	8	cellassociated	cellassociate	VBN
cord-272051-arz8r204	188	9	fluorescence	fluorescence	NN
cord-272051-arz8r204	188	10	have	have	VBP
cord-272051-arz8r204	188	11	been	be	VBN
cord-272051-arz8r204	188	12	detected	detect	VBN
cord-272051-arz8r204	188	13	in	in	IN
cord-272051-arz8r204	188	14	PI	pi	NN
cord-272051-arz8r204	188	15	-	-	HYPH
cord-272051-arz8r204	188	16	treated	treat	VBN
cord-272051-arz8r204	188	17	cells	cell	NNS
cord-272051-arz8r204	188	18	as	as	IN
cord-272051-arz8r204	188	19	compared	compare	VBN
cord-272051-arz8r204	188	20	with	with	IN
cord-272051-arz8r204	188	21	control	control	NN
cord-272051-arz8r204	188	22	conditions	condition	NNS
cord-272051-arz8r204	188	23	,	,	,
cord-272051-arz8r204	188	24	indicating	indicate	VBG
cord-272051-arz8r204	188	25	that	that	IN
cord-272051-arz8r204	188	26	PIs	pi	NNS
cord-272051-arz8r204	188	27	do	do	VBP
cord-272051-arz8r204	188	28	not	not	RB
cord-272051-arz8r204	188	29	affect	affect	VB
cord-272051-arz8r204	188	30	the	the	DT
cord-272051-arz8r204	188	31	intracellular	intracellular	JJ
cord-272051-arz8r204	188	32	pH.	ph.	NN
cord-272051-arz8r204	189	1	These	these	DT
cord-272051-arz8r204	189	2	results	result	NNS
cord-272051-arz8r204	189	3	strongly	strongly	RB
cord-272051-arz8r204	189	4	suggest	suggest	VBP
cord-272051-arz8r204	189	5	that	that	IN
cord-272051-arz8r204	189	6	the	the	DT
cord-272051-arz8r204	189	7	PI	pi	NN
cord-272051-arz8r204	189	8	-	-	HYPH
cord-272051-arz8r204	189	9	induced	induce	VBN
cord-272051-arz8r204	189	10	block	block	NN
cord-272051-arz8r204	189	11	of	of	IN
cord-272051-arz8r204	189	12	virus	virus	NN
cord-272051-arz8r204	189	13	delivery	delivery	NN
cord-272051-arz8r204	189	14	in	in	IN
cord-272051-arz8r204	189	15	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	189	16	would	would	MD
cord-272051-arz8r204	189	17	not	not	RB
cord-272051-arz8r204	189	18	be	be	VB
cord-272051-arz8r204	189	19	a	a	DT
cord-272051-arz8r204	189	20	consequence	consequence	NN
cord-272051-arz8r204	189	21	of	of	IN
cord-272051-arz8r204	189	22	the	the	DT
cord-272051-arz8r204	189	23	increase	increase	NN
cord-272051-arz8r204	189	24	of	of	IN
cord-272051-arz8r204	189	25	endosomal	endosomal	NNP
cord-272051-arz8r204	190	1	pH.	pH.	NNP
cord-272051-arz8r204	190	2	Viruses	Viruses	NNP
cord-272051-arz8r204	190	3	hijack	hijack	VBP
cord-272051-arz8r204	190	4	cell	cell	NN
cord-272051-arz8r204	190	5	functions	function	NNS
cord-272051-arz8r204	190	6	to	to	TO
cord-272051-arz8r204	190	7	replicate	replicate	VB
cord-272051-arz8r204	190	8	in	in	IN
cord-272051-arz8r204	190	9	host	host	NN
cord-272051-arz8r204	190	10	cells	cell	NNS
cord-272051-arz8r204	190	11	.	.	.
cord-272051-arz8r204	191	1	Hence	hence	RB
cord-272051-arz8r204	191	2	,	,	,
cord-272051-arz8r204	191	3	the	the	DT
cord-272051-arz8r204	191	4	selective	selective	JJ
cord-272051-arz8r204	191	5	targeting	targeting	NN
cord-272051-arz8r204	191	6	of	of	IN
cord-272051-arz8r204	191	7	cell	cell	NN
cord-272051-arz8r204	191	8	products	product	NNS
cord-272051-arz8r204	191	9	supporting	support	VBG
cord-272051-arz8r204	191	10	virus	virus	NN
cord-272051-arz8r204	191	11	replication	replication	NN
cord-272051-arz8r204	191	12	could	could	MD
cord-272051-arz8r204	191	13	represent	represent	VB
cord-272051-arz8r204	191	14	a	a	DT
cord-272051-arz8r204	191	15	successful	successful	JJ
cord-272051-arz8r204	191	16	antiviral	antiviral	JJ
cord-272051-arz8r204	191	17	strategy	strategy	NN
cord-272051-arz8r204	191	18	.	.	.
cord-272051-arz8r204	192	1	The	the	DT
cord-272051-arz8r204	192	2	results	result	NNS
cord-272051-arz8r204	192	3	from	from	IN
cord-272051-arz8r204	192	4	the	the	DT
cord-272051-arz8r204	192	5	here	here	RB
cord-272051-arz8r204	192	6	described	describe	VBN
cord-272051-arz8r204	192	7	investigations	investigation	NNS
cord-272051-arz8r204	192	8	indicate	indicate	VBP
cord-272051-arz8r204	192	9	that	that	IN
cord-272051-arz8r204	192	10	drugs	drug	NNS
cord-272051-arz8r204	192	11	designed	design	VBN
cord-272051-arz8r204	192	12	to	to	TO
cord-272051-arz8r204	192	13	counteract	counteract	VB
cord-272051-arz8r204	192	14	the	the	DT
cord-272051-arz8r204	192	15	activity	activity	NN
cord-272051-arz8r204	192	16	of	of	IN
cord-272051-arz8r204	192	17	the	the	DT
cord-272051-arz8r204	192	18	HIV	HIV	NNP
cord-272051-arz8r204	192	19	protease	protease	NN
cord-272051-arz8r204	192	20	show	show	VBP
cord-272051-arz8r204	192	21	a	a	DT
cord-272051-arz8r204	192	22	strong	strong	JJ
cord-272051-arz8r204	192	23	inhibitory	inhibitory	JJ
cord-272051-arz8r204	192	24	effect	effect	NN
cord-272051-arz8r204	192	25	against	against	IN
cord-272051-arz8r204	192	26	activity(ies	activity(ie	NNS
cord-272051-arz8r204	192	27	)	)	-RRB-
cord-272051-arz8r204	192	28	of	of	IN
cord-272051-arz8r204	192	29	target	target	NN
cord-272051-arz8r204	192	30	cells	cell	NNS
cord-272051-arz8r204	192	31	.	.	.
cord-272051-arz8r204	193	1	The	the	DT
cord-272051-arz8r204	193	2	antiviral	antiviral	JJ
cord-272051-arz8r204	193	3	potency	potency	NN
cord-272051-arz8r204	193	4	of	of	IN
cord-272051-arz8r204	193	5	the	the	DT
cord-272051-arz8r204	193	6	most	most	RBS
cord-272051-arz8r204	193	7	effective	effective	JJ
cord-272051-arz8r204	193	8	PIs	pi	NNS
cord-272051-arz8r204	193	9	reached	reach	VBD
cord-272051-arz8r204	193	10	about	about	RB
cord-272051-arz8r204	193	11	4	4	CD
cord-272051-arz8r204	193	12	logs	log	NNS
cord-272051-arz8r204	193	13	in	in	IN
cord-272051-arz8r204	193	14	the	the	DT
cord-272051-arz8r204	193	15	reduction	reduction	NN
cord-272051-arz8r204	193	16	of	of	IN
cord-272051-arz8r204	193	17	virus	virus	NN
cord-272051-arz8r204	193	18	yields	yield	NNS
cord-272051-arz8r204	193	19	,	,	,
cord-272051-arz8r204	193	20	with	with	IN
cord-272051-arz8r204	193	21	therapeutic	therapeutic	JJ
cord-272051-arz8r204	193	22	indexes	index	NNS
cord-272051-arz8r204	193	23	higher	high	JJR
cord-272051-arz8r204	193	24	than	than	IN
cord-272051-arz8r204	193	25	15	15	CD
cord-272051-arz8r204	193	26	.	.	.
cord-272051-arz8r204	194	1	The	the	DT
cord-272051-arz8r204	194	2	PI	pi	NN
cord-272051-arz8r204	194	3	-	-	HYPH
cord-272051-arz8r204	194	4	induced	induce	VBN
cord-272051-arz8r204	194	5	effect	effect	NN
cord-272051-arz8r204	194	6	against	against	IN
cord-272051-arz8r204	194	7	VSV	VSV	NNP
cord-272051-arz8r204	194	8	appeared	appear	VBD
cord-272051-arz8r204	194	9	comparable	comparable	JJ
cord-272051-arz8r204	194	10	in	in	IN
cord-272051-arz8r204	194	11	magnitude	magnitude	NN
cord-272051-arz8r204	194	12	to	to	IN
cord-272051-arz8r204	194	13	that	that	DT
cord-272051-arz8r204	194	14	observed	observe	VBN
cord-272051-arz8r204	194	15	in	in	IN
cord-272051-arz8r204	194	16	cell	cell	NN
cord-272051-arz8r204	194	17	treated	treat	VBN
cord-272051-arz8r204	194	18	with	with	IN
cord-272051-arz8r204	194	19	type-1	type-1	NN
cord-272051-arz8r204	194	20	interferons	interferon	NNS
cord-272051-arz8r204	194	21	(	(	-LRB-
cord-272051-arz8r204	194	22	Masters	Masters	NNPS
cord-272051-arz8r204	194	23	and	and	CC
cord-272051-arz8r204	194	24	Samuel	Samuel	NNP
cord-272051-arz8r204	194	25	,	,	,
cord-272051-arz8r204	194	26	1983	1983	CD
cord-272051-arz8r204	194	27	)	)	-RRB-
cord-272051-arz8r204	194	28	.	.	.
cord-272051-arz8r204	195	1	On	on	IN
cord-272051-arz8r204	195	2	the	the	DT
cord-272051-arz8r204	195	3	other	other	JJ
cord-272051-arz8r204	195	4	hand	hand	NN
cord-272051-arz8r204	195	5	,	,	,
cord-272051-arz8r204	195	6	the	the	DT
cord-272051-arz8r204	195	7	potency	potency	NN
cord-272051-arz8r204	195	8	of	of	IN
cord-272051-arz8r204	195	9	PIs	pi	NNS
cord-272051-arz8r204	195	10	against	against	IN
cord-272051-arz8r204	195	11	the	the	DT
cord-272051-arz8r204	195	12	influenza	influenza	NN
cord-272051-arz8r204	195	13	virus	virus	NN
cord-272051-arz8r204	195	14	replication	replication	NN
cord-272051-arz8r204	195	15	appeared	appear	VBD
cord-272051-arz8r204	195	16	comparable	comparable	JJ
cord-272051-arz8r204	195	17	to	to	IN
cord-272051-arz8r204	195	18	that	that	DT
cord-272051-arz8r204	195	19	of	of	IN
cord-272051-arz8r204	195	20	most	most	RBS
cord-272051-arz8r204	195	21	potent	potent	JJ
cord-272051-arz8r204	195	22	inhibitors	inhibitor	NNS
cord-272051-arz8r204	195	23	.	.	.
cord-272051-arz8r204	196	1	Among	among	IN
cord-272051-arz8r204	196	2	these	these	DT
cord-272051-arz8r204	196	3	,	,	,
cord-272051-arz8r204	196	4	T-705	T-705	NNS
cord-272051-arz8r204	196	5	(	(	-LRB-
cord-272051-arz8r204	196	6	Furuta	Furuta	NNP
cord-272051-arz8r204	196	7	et	et	FW
cord-272051-arz8r204	196	8	al	al	NNP
cord-272051-arz8r204	196	9	.	.	NNP
cord-272051-arz8r204	196	10	,	,	,
cord-272051-arz8r204	196	11	2002	2002	CD
cord-272051-arz8r204	196	12	)	)	-RRB-
cord-272051-arz8r204	196	13	reduced	reduce	VBD
cord-272051-arz8r204	196	14	the	the	DT
cord-272051-arz8r204	196	15	viral	viral	JJ
cord-272051-arz8r204	196	16	yield	yield	NN
cord-272051-arz8r204	196	17	of	of	IN
cord-272051-arz8r204	196	18	the	the	DT
cord-272051-arz8r204	196	19	most	most	RBS
cord-272051-arz8r204	196	20	susceptible	susceptible	JJ
cord-272051-arz8r204	196	21	influenza	influenza	NN
cord-272051-arz8r204	196	22	strain	strain	NN
cord-272051-arz8r204	196	23	tested	test	VBN
cord-272051-arz8r204	196	24	of	of	IN
cord-272051-arz8r204	196	25	at	at	IN
cord-272051-arz8r204	196	26	best	good	JJS
cord-272051-arz8r204	196	27	2.7	2.7	CD
cord-272051-arz8r204	196	28	logs	log	NNS
cord-272051-arz8r204	196	29	at	at	IN
cord-272051-arz8r204	196	30	the	the	DT
cord-272051-arz8r204	196	31	concentration	concentration	NN
cord-272051-arz8r204	196	32	of	of	IN
cord-272051-arz8r204	196	33	5	5	CD
cord-272051-arz8r204	196	34	μM	μm	NN
cord-272051-arz8r204	196	35	upon	upon	IN
cord-272051-arz8r204	196	36	MDCK	MDCK	NNP
cord-272051-arz8r204	196	37	cell	cell	NN
cord-272051-arz8r204	196	38	challenge	challenge	NN
cord-272051-arz8r204	196	39	with	with	IN
cord-272051-arz8r204	196	40	0.01	0.01	CD
cord-272051-arz8r204	196	41	m.o.i	m.o.i	NN
cord-272051-arz8r204	196	42	.	.	.
cord-272051-arz8r204	197	1	(	(	-LRB-
cord-272051-arz8r204	197	2	Sleeman	Sleeman	NNP
cord-272051-arz8r204	197	3	et	et	NNP
cord-272051-arz8r204	197	4	al	al	NNP
cord-272051-arz8r204	197	5	.	.	NNP
cord-272051-arz8r204	197	6	,	,	,
cord-272051-arz8r204	197	7	2010	2010	CD
cord-272051-arz8r204	197	8	)	)	-RRB-
cord-272051-arz8r204	197	9	.	.	.
cord-272051-arz8r204	198	1	DAS181	DAS181	NNP
cord-272051-arz8r204	198	2	,	,	,
cord-272051-arz8r204	198	3	i.e.	i.e.	FW
cord-272051-arz8r204	198	4	a	a	DT
cord-272051-arz8r204	198	5	sialidase	sialidase	NN
cord-272051-arz8r204	198	6	fusion	fusion	NN
cord-272051-arz8r204	198	7	protein	protein	NN
cord-272051-arz8r204	198	8	,	,	,
cord-272051-arz8r204	198	9	blocked	block	VBD
cord-272051-arz8r204	198	10	the	the	DT
cord-272051-arz8r204	198	11	influenza	influenza	NN
cord-272051-arz8r204	198	12	virus	virus	NN
cord-272051-arz8r204	198	13	replication	replication	NN
cord-272051-arz8r204	198	14	at	at	IN
cord-272051-arz8r204	198	15	sub	sub	JJ
cord-272051-arz8r204	198	16	-	-	JJ
cord-272051-arz8r204	198	17	micromolar	micromolar	JJ
cord-272051-arz8r204	198	18	concentrations	concentration	NNS
cord-272051-arz8r204	198	19	,	,	,
cord-272051-arz8r204	198	20	however	however	RB
cord-272051-arz8r204	198	21	when	when	WRB
cord-272051-arz8r204	198	22	MDCK	MDCK	NNP
cord-272051-arz8r204	198	23	cells	cell	NNS
cord-272051-arz8r204	198	24	were	be	VBD
cord-272051-arz8r204	198	25	challenged	challenge	VBN
cord-272051-arz8r204	198	26	with	with	IN
cord-272051-arz8r204	198	27	0.001	0.001	CD
cord-272051-arz8r204	198	28	-	-	SYM
cord-272051-arz8r204	198	29	0.005	0.005	CD
cord-272051-arz8r204	198	30	m.o.i	m.o.i	NN
cord-272051-arz8r204	198	31	.	.	.
cord-272051-arz8r204	199	1	(	(	-LRB-
cord-272051-arz8r204	199	2	Triana	Triana	NNP
cord-272051-arz8r204	199	3	-	-	HYPH
cord-272051-arz8r204	199	4	Baltzer	Baltzer	NNP
cord-272051-arz8r204	199	5	et	et	NNP
cord-272051-arz8r204	199	6	al	al	NNP
cord-272051-arz8r204	199	7	.	.	NNP
cord-272051-arz8r204	199	8	,	,	,
cord-272051-arz8r204	199	9	2009	2009	CD
cord-272051-arz8r204	199	10	)	)	-RRB-
cord-272051-arz8r204	199	11	.	.	.
cord-272051-arz8r204	200	1	Conversely	conversely	RB
cord-272051-arz8r204	200	2	,	,	,
cord-272051-arz8r204	200	3	micromolar	micromolar	JJ
cord-272051-arz8r204	200	4	concentrations	concentration	NNS
cord-272051-arz8r204	200	5	of	of	IN
cord-272051-arz8r204	200	6	PIs	pi	NNS
cord-272051-arz8r204	200	7	induced	induce	VBD
cord-272051-arz8r204	200	8	more	more	JJR
cord-272051-arz8r204	200	9	than	than	IN
cord-272051-arz8r204	200	10	3	3	CD
cord-272051-arz8r204	200	11	logs	log	NNS
cord-272051-arz8r204	200	12	of	of	IN
cord-272051-arz8r204	200	13	reduction	reduction	NN
cord-272051-arz8r204	200	14	of	of	IN
cord-272051-arz8r204	200	15	the	the	DT
cord-272051-arz8r204	200	16	influenza	influenza	NN
cord-272051-arz8r204	200	17	virus	virus	NN
cord-272051-arz8r204	200	18	yield	yield	NN
cord-272051-arz8r204	200	19	from	from	IN
cord-272051-arz8r204	200	20	MDCK	MDCK	NNP
cord-272051-arz8r204	200	21	cells	cell	NNS
cord-272051-arz8r204	200	22	challenged	challenge	VBN
cord-272051-arz8r204	200	23	with	with	IN
cord-272051-arz8r204	200	24	0.5	0.5	CD
cord-272051-arz8r204	200	25	m.o.i	m.o.i	NN
cord-272051-arz8r204	200	26	.	.	.
cord-272051-arz8r204	201	1	In	in	IN
cord-272051-arz8r204	201	2	the	the	DT
cord-272051-arz8r204	201	3	challenge	challenge	NN
cord-272051-arz8r204	201	4	experiments	experiment	NNS
cord-272051-arz8r204	201	5	where	where	WRB
cord-272051-arz8r204	201	6	PIs	pi	NNS
cord-272051-arz8r204	201	7	were	be	VBD
cord-272051-arz8r204	201	8	added	add	VBN
cord-272051-arz8r204	201	9	soon	soon	RB
cord-272051-arz8r204	201	10	after	after	IN
cord-272051-arz8r204	201	11	the	the	DT
cord-272051-arz8r204	201	12	adsorption	adsorption	NN
cord-272051-arz8r204	201	13	of	of	IN
cord-272051-arz8r204	201	14	VSV	VSV	NNP
cord-272051-arz8r204	201	15	or	or	CC
cord-272051-arz8r204	201	16	influenza	influenza	NN
cord-272051-arz8r204	201	17	virus	virus	NN
cord-272051-arz8r204	201	18	inocula	inocula	NNP
cord-272051-arz8r204	201	19	,	,	,
cord-272051-arz8r204	201	20	the	the	DT
cord-272051-arz8r204	201	21	antiviral	antiviral	JJ
cord-272051-arz8r204	201	22	effect	effect	NN
cord-272051-arz8r204	201	23	appeared	appear	VBD
cord-272051-arz8r204	201	24	slightly	slightly	RB
cord-272051-arz8r204	201	25	reduced	reduce	VBN
cord-272051-arz8r204	201	26	as	as	IN
cord-272051-arz8r204	201	27	compared	compare	VBN
cord-272051-arz8r204	201	28	with	with	IN
cord-272051-arz8r204	201	29	control	control	NN
cord-272051-arz8r204	201	30	conditions	condition	NNS
cord-272051-arz8r204	201	31	where	where	WRB
cord-272051-arz8r204	201	32	PIs	pi	NNS
cord-272051-arz8r204	201	33	were	be	VBD
cord-272051-arz8r204	201	34	maintained	maintain	VBN
cord-272051-arz8r204	201	35	throughout	throughout	IN
cord-272051-arz8r204	201	36	.	.	.
cord-272051-arz8r204	202	1	Considering	consider	VBG
cord-272051-arz8r204	202	2	also	also	RB
cord-272051-arz8r204	202	3	the	the	DT
cord-272051-arz8r204	202	4	results	result	NNS
cord-272051-arz8r204	202	5	obtained	obtain	VBN
cord-272051-arz8r204	202	6	in	in	IN
cord-272051-arz8r204	202	7	the	the	DT
cord-272051-arz8r204	202	8	endocytosis	endocytosis	NN
cord-272051-arz8r204	202	9	assays	assay	NNS
cord-272051-arz8r204	202	10	,	,	,
cord-272051-arz8r204	202	11	it	-PRON-	PRP
cord-272051-arz8r204	202	12	is	be	VBZ
cord-272051-arz8r204	202	13	conceivable	conceivable	JJ
cord-272051-arz8r204	202	14	that	that	IN
cord-272051-arz8r204	202	15	this	this	DT
cord-272051-arz8r204	202	16	subtle	subtle	JJ
cord-272051-arz8r204	202	17	difference	difference	NN
cord-272051-arz8r204	202	18	could	could	MD
cord-272051-arz8r204	202	19	be	be	VB
cord-272051-arz8r204	202	20	a	a	DT
cord-272051-arz8r204	202	21	consequence	consequence	NN
cord-272051-arz8r204	202	22	of	of	IN
cord-272051-arz8r204	202	23	the	the	DT
cord-272051-arz8r204	202	24	accession	accession	NN
cord-272051-arz8r204	202	25	to	to	TO
cord-272051-arz8r204	202	26	cytoplasm	cytoplasm	VB
cord-272051-arz8r204	202	27	of	of	IN
cord-272051-arz8r204	202	28	a	a	DT
cord-272051-arz8r204	202	29	small	small	JJ
cord-272051-arz8r204	202	30	amount	amount	NN
cord-272051-arz8r204	202	31	of	of	IN
cord-272051-arz8r204	202	32	viral	viral	JJ
cord-272051-arz8r204	202	33	particles	particle	NNS
cord-272051-arz8r204	202	34	during	during	IN
cord-272051-arz8r204	202	35	the	the	DT
cord-272051-arz8r204	202	36	adsorption	adsorption	NN
cord-272051-arz8r204	202	37	time	time	NN
cord-272051-arz8r204	202	38	and	and	CC
cord-272051-arz8r204	202	39	before	before	IN
cord-272051-arz8r204	202	40	the	the	DT
cord-272051-arz8r204	202	41	PI	PI	NNP
cord-272051-arz8r204	202	42	treatment	treatment	NN
cord-272051-arz8r204	202	43	.	.	.
cord-272051-arz8r204	203	1	The	the	DT
cord-272051-arz8r204	203	2	possibility	possibility	NN
cord-272051-arz8r204	203	3	that	that	IN
cord-272051-arz8r204	203	4	PIs	pi	NNS
cord-272051-arz8r204	203	5	affect	affect	VBP
cord-272051-arz8r204	203	6	some	some	DT
cord-272051-arz8r204	203	7	virion	virion	NN
cord-272051-arz8r204	203	8	structural	structural	JJ
cord-272051-arz8r204	203	9	component	component	NN
cord-272051-arz8r204	203	10	in	in	IN
cord-272051-arz8r204	203	11	a	a	DT
cord-272051-arz8r204	203	12	way	way	NN
cord-272051-arz8r204	203	13	to	to	TO
cord-272051-arz8r204	203	14	hinder	hinder	VB
cord-272051-arz8r204	203	15	the	the	DT
cord-272051-arz8r204	203	16	process	process	NN
cord-272051-arz8r204	203	17	of	of	IN
cord-272051-arz8r204	203	18	fusion	fusion	NN
cord-272051-arz8r204	203	19	in	in	IN
cord-272051-arz8r204	203	20	endosomes	endosome	NNS
cord-272051-arz8r204	203	21	appeared	appear	VBD
cord-272051-arz8r204	203	22	unlikely	unlikely	JJ
cord-272051-arz8r204	203	23	.	.	.
cord-272051-arz8r204	204	1	In	in	IN
cord-272051-arz8r204	204	2	fact	fact	NN
cord-272051-arz8r204	204	3	,	,	,
cord-272051-arz8r204	204	4	the	the	DT
cord-272051-arz8r204	204	5	treatment	treatment	NN
cord-272051-arz8r204	204	6	of	of	IN
cord-272051-arz8r204	204	7	10-fold	10-fold	JJ
cord-272051-arz8r204	204	8	concentrated	concentrated	JJ
cord-272051-arz8r204	204	9	VSV	VSV	NNP
cord-272051-arz8r204	204	10	or	or	CC
cord-272051-arz8r204	204	11	influenza	influenza	NN
cord-272051-arz8r204	204	12	virus	virus	NN
cord-272051-arz8r204	204	13	preparations	preparation	NNS
cord-272051-arz8r204	204	14	with	with	IN
cord-272051-arz8r204	204	15	up	up	IN
cord-272051-arz8r204	204	16	to	to	TO
cord-272051-arz8r204	204	17	500	500	CD
cord-272051-arz8r204	204	18	μM	μm	CD
cord-272051-arz8r204	204	19	PIs	pi	NNS
cord-272051-arz8r204	204	20	for	for	IN
cord-272051-arz8r204	204	21	30	30	CD
cord-272051-arz8r204	204	22	min	min	NN
cord-272051-arz8r204	204	23	before	before	IN
cord-272051-arz8r204	204	24	challenge	challenge	NN
cord-272051-arz8r204	204	25	did	do	VBD
cord-272051-arz8r204	204	26	not	not	RB
cord-272051-arz8r204	204	27	produce	produce	VB
cord-272051-arz8r204	204	28	significant	significant	JJ
cord-272051-arz8r204	204	29	decrease	decrease	NN
cord-272051-arz8r204	204	30	of	of	IN
cord-272051-arz8r204	204	31	the	the	DT
cord-272051-arz8r204	204	32	viral	viral	JJ
cord-272051-arz8r204	204	33	yields	yield	NNS
cord-272051-arz8r204	204	34	(	(	-LRB-
cord-272051-arz8r204	204	35	not	not	RB
cord-272051-arz8r204	204	36	shown	show	VBN
cord-272051-arz8r204	204	37	)	)	-RRB-
cord-272051-arz8r204	204	38	.	.	.
cord-272051-arz8r204	205	1	However	however	RB
cord-272051-arz8r204	205	2	,	,	,
cord-272051-arz8r204	205	3	we	-PRON-	PRP
cord-272051-arz8r204	205	4	can	can	MD
cord-272051-arz8r204	205	5	not	not	RB
cord-272051-arz8r204	205	6	formally	formally	RB
cord-272051-arz8r204	205	7	exclude	exclude	VB
cord-272051-arz8r204	205	8	that	that	IN
cord-272051-arz8r204	205	9	PIs	pi	NNS
cord-272051-arz8r204	205	10	inhibit	inhibit	VB
cord-272051-arz8r204	205	11	some	some	DT
cord-272051-arz8r204	205	12	yet	yet	RB
cord-272051-arz8r204	205	13	unidentified	unidentified	JJ
cord-272051-arz8r204	205	14	protease	protease	NN
cord-272051-arz8r204	205	15	activity	activity	NN
cord-272051-arz8r204	205	16	associated	associate	VBN
cord-272051-arz8r204	205	17	with	with	IN
cord-272051-arz8r204	205	18	VSV	VSV	NNP
cord-272051-arz8r204	205	19	-	-	HYPH
cord-272051-arz8r204	205	20	G	G	NNP
cord-272051-arz8r204	205	21	or	or	CC
cord-272051-arz8r204	205	22	influenza	influenza	NN
cord-272051-arz8r204	205	23	virions	virion	NNS
cord-272051-arz8r204	205	24	.	.	.
cord-272051-arz8r204	206	1	In	in	IN
cord-272051-arz8r204	206	2	this	this	DT
cord-272051-arz8r204	206	3	regard	regard	NN
cord-272051-arz8r204	206	4	,	,	,
cord-272051-arz8r204	206	5	it	-PRON-	PRP
cord-272051-arz8r204	206	6	has	have	VBZ
cord-272051-arz8r204	206	7	been	be	VBN
cord-272051-arz8r204	206	8	proposed	propose	VBN
cord-272051-arz8r204	206	9	that	that	IN
cord-272051-arz8r204	206	10	PIs	pi	NNS
cord-272051-arz8r204	206	11	could	could	MD
cord-272051-arz8r204	206	12	negatively	negatively	RB
cord-272051-arz8r204	206	13	affect	affect	VB
cord-272051-arz8r204	206	14	the	the	DT
cord-272051-arz8r204	206	15	chymotrypsin	chymotrypsin	JJ
cord-272051-arz8r204	206	16	-	-	HYPH
cord-272051-arz8r204	206	17	like	like	JJ
cord-272051-arz8r204	206	18	protease	protease	NN
cord-272051-arz8r204	206	19	activity	activity	NN
cord-272051-arz8r204	206	20	of	of	IN
cord-272051-arz8r204	206	21	the	the	DT
cord-272051-arz8r204	206	22	PA	PA	NNP
cord-272051-arz8r204	206	23	subunit	subunit	NN
cord-272051-arz8r204	206	24	of	of	IN
cord-272051-arz8r204	206	25	the	the	DT
cord-272051-arz8r204	206	26	RNA	RNA	NNP
cord-272051-arz8r204	206	27	-	-	HYPH
cord-272051-arz8r204	206	28	directed	direct	VBN
cord-272051-arz8r204	206	29	RNA	RNA	NNP
cord-272051-arz8r204	206	30	polymerase	polymerase	NN
cord-272051-arz8r204	206	31	of	of	IN
cord-272051-arz8r204	206	32	influenza	influenza	NN
cord-272051-arz8r204	206	33	virus	virus	NN
cord-272051-arz8r204	206	34	(	(	-LRB-
cord-272051-arz8r204	206	35	Savarino	Savarino	NNP
cord-272051-arz8r204	206	36	,	,	,
cord-272051-arz8r204	206	37	2005	2005	CD
cord-272051-arz8r204	206	38	)	)	-RRB-
cord-272051-arz8r204	206	39	.	.	.
cord-272051-arz8r204	207	1	Furthermore	furthermore	RB
cord-272051-arz8r204	207	2	,	,	,
cord-272051-arz8r204	207	3	it	-PRON-	PRP
cord-272051-arz8r204	207	4	was	be	VBD
cord-272051-arz8r204	207	5	reported	report	VBN
cord-272051-arz8r204	207	6	that	that	IN
cord-272051-arz8r204	207	7	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	207	8	reduces	reduce	VBZ
cord-272051-arz8r204	207	9	the	the	DT
cord-272051-arz8r204	207	10	replication	replication	NN
cord-272051-arz8r204	207	11	of	of	IN
cord-272051-arz8r204	207	12	SARS	SARS	NNP
cord-272051-arz8r204	207	13	coronavirus	coronavirus	NN
cord-272051-arz8r204	207	14	(	(	-LRB-
cord-272051-arz8r204	207	15	Yamamoto	Yamamoto	NNP
cord-272051-arz8r204	207	16	et	et	NNP
cord-272051-arz8r204	207	17	al	al	NNP
cord-272051-arz8r204	207	18	.	.	NNP
cord-272051-arz8r204	207	19	,	,	,
cord-272051-arz8r204	207	20	2004	2004	CD
cord-272051-arz8r204	207	21	)	)	-RRB-
cord-272051-arz8r204	207	22	likely	likely	JJ
cord-272051-arz8r204	207	23	as	as	IN
cord-272051-arz8r204	207	24	a	a	DT
cord-272051-arz8r204	207	25	consequence	consequence	NN
cord-272051-arz8r204	207	26	of	of	IN
cord-272051-arz8r204	207	27	the	the	DT
cord-272051-arz8r204	207	28	inhibition	inhibition	NN
cord-272051-arz8r204	207	29	of	of	IN
cord-272051-arz8r204	207	30	the	the	DT
cord-272051-arz8r204	207	31	3C	3c	NN
cord-272051-arz8r204	207	32	-	-	HYPH
cord-272051-arz8r204	207	33	like	like	JJ
cord-272051-arz8r204	207	34	viral	viral	JJ
cord-272051-arz8r204	207	35	protease	protease	NN
cord-272051-arz8r204	207	36	(	(	-LRB-
cord-272051-arz8r204	207	37	for	for	IN
cord-272051-arz8r204	207	38	a	a	DT
cord-272051-arz8r204	207	39	review	review	NN
cord-272051-arz8r204	207	40	,	,	,
cord-272051-arz8r204	207	41	see	see	VB
cord-272051-arz8r204	207	42	35	35	CD
cord-272051-arz8r204	207	43	)	)	-RRB-
cord-272051-arz8r204	207	44	.	.	.
cord-272051-arz8r204	208	1	The	the	DT
cord-272051-arz8r204	208	2	results	result	NNS
cord-272051-arz8r204	208	3	from	from	IN
cord-272051-arz8r204	208	4	here	here	RB
cord-272051-arz8r204	208	5	reported	report	VBN
cord-272051-arz8r204	208	6	experiments	experiment	NNS
cord-272051-arz8r204	208	7	indicate	indicate	VBP
cord-272051-arz8r204	208	8	that	that	IN
cord-272051-arz8r204	208	9	PIs	PIs	NNP
cord-272051-arz8r204	208	10	act	act	VB
cord-272051-arz8r204	208	11	on	on	IN
cord-272051-arz8r204	208	12	early	early	JJ
cord-272051-arz8r204	208	13	events	event	NNS
cord-272051-arz8r204	208	14	of	of	IN
cord-272051-arz8r204	208	15	viral	viral	JJ
cord-272051-arz8r204	208	16	replication	replication	NN
cord-272051-arz8r204	208	17	,	,	,
cord-272051-arz8r204	208	18	but	but	CC
cord-272051-arz8r204	208	19	not	not	RB
cord-272051-arz8r204	208	20	on	on	IN
cord-272051-arz8r204	208	21	virus	virus	NN
cord-272051-arz8r204	208	22	attachment	attachment	NN
cord-272051-arz8r204	208	23	and	and	CC
cord-272051-arz8r204	208	24	endocytosis	endocytosis	NN
cord-272051-arz8r204	208	25	.	.	.
cord-272051-arz8r204	209	1	This	this	DT
cord-272051-arz8r204	209	2	latter	latter	JJ
cord-272051-arz8r204	209	3	finding	finding	NN
cord-272051-arz8r204	209	4	was	be	VBD
cord-272051-arz8r204	209	5	consistent	consistent	JJ
cord-272051-arz8r204	209	6	with	with	IN
cord-272051-arz8r204	209	7	previously	previously	RB
cord-272051-arz8r204	209	8	reported	report	VBN
cord-272051-arz8r204	209	9	results	result	NNS
cord-272051-arz8r204	209	10	indicating	indicate	VBG
cord-272051-arz8r204	209	11	that	that	IN
cord-272051-arz8r204	209	12	PIs	pi	NNS
cord-272051-arz8r204	209	13	do	do	VBP
cord-272051-arz8r204	209	14	not	not	RB
cord-272051-arz8r204	209	15	affect	affect	VB
cord-272051-arz8r204	209	16	the	the	DT
cord-272051-arz8r204	209	17	endocytosis	endocytosis	NN
cord-272051-arz8r204	209	18	of	of	IN
cord-272051-arz8r204	209	19	HIV-1	HIV-1	NNP
cord-272051-arz8r204	209	20	particles	particle	NNS
cord-272051-arz8r204	209	21	in	in	IN
cord-272051-arz8r204	209	22	dendritic	dendritic	JJ
cord-272051-arz8r204	209	23	cells	cell	NNS
cord-272051-arz8r204	209	24	(	(	-LRB-
cord-272051-arz8r204	210	1	Muratori	Muratori	NNP
cord-272051-arz8r204	210	2	et	et	NNP
cord-272051-arz8r204	210	3	al	al	NNP
cord-272051-arz8r204	210	4	.	.	NNP
cord-272051-arz8r204	210	5	,	,	,
cord-272051-arz8r204	210	6	2009	2009	CD
cord-272051-arz8r204	210	7	)	)	-RRB-
cord-272051-arz8r204	210	8	.	.	.
cord-272051-arz8r204	211	1	Rather	rather	RB
cord-272051-arz8r204	211	2	,	,	,
cord-272051-arz8r204	211	3	it	-PRON-	PRP
cord-272051-arz8r204	211	4	appeared	appear	VBD
cord-272051-arz8r204	211	5	that	that	IN
cord-272051-arz8r204	211	6	PIs	pi	NNS
cord-272051-arz8r204	211	7	interfere	interfere	VB
cord-272051-arz8r204	211	8	with	with	IN
cord-272051-arz8r204	211	9	the	the	DT
cord-272051-arz8r204	211	10	delivery	delivery	NN
cord-272051-arz8r204	211	11	of	of	IN
cord-272051-arz8r204	211	12	viral	viral	JJ
cord-272051-arz8r204	211	13	particles	particle	NNS
cord-272051-arz8r204	211	14	from	from	IN
cord-272051-arz8r204	211	15	endosomes	endosome	NNS
cord-272051-arz8r204	211	16	to	to	IN
cord-272051-arz8r204	211	17	cytoplasm	cytoplasm	NN
cord-272051-arz8r204	211	18	.	.	.
cord-272051-arz8r204	212	1	This	this	DT
cord-272051-arz8r204	212	2	did	do	VBD
cord-272051-arz8r204	212	3	not	not	RB
cord-272051-arz8r204	212	4	seem	seem	VB
cord-272051-arz8r204	212	5	to	to	TO
cord-272051-arz8r204	212	6	depend	depend	VB
cord-272051-arz8r204	212	7	on	on	IN
cord-272051-arz8r204	212	8	a	a	DT
cord-272051-arz8r204	212	9	PI	pi	NN
cord-272051-arz8r204	212	10	-	-	HYPH
cord-272051-arz8r204	212	11	induced	induce	VBN
cord-272051-arz8r204	212	12	increase	increase	NN
cord-272051-arz8r204	212	13	of	of	IN
cord-272051-arz8r204	212	14	the	the	DT
cord-272051-arz8r204	212	15	endosomal	endosomal	NNP
cord-272051-arz8r204	213	1	pH	pH	NNP
cord-272051-arz8r204	213	2	possibly	possibly	RB
cord-272051-arz8r204	213	3	inhibiting	inhibit	VBG
cord-272051-arz8r204	213	4	the	the	DT
cord-272051-arz8r204	213	5	low	low	JJ
cord-272051-arz8r204	213	6	pHdependent	pHdependent	NNP
cord-272051-arz8r204	213	7	conformational	conformational	JJ
cord-272051-arz8r204	213	8	changes	change	NNS
cord-272051-arz8r204	213	9	of	of	IN
cord-272051-arz8r204	213	10	viral	viral	JJ
cord-272051-arz8r204	213	11	envelope	envelope	NN
cord-272051-arz8r204	213	12	proteins	protein	NNS
cord-272051-arz8r204	213	13	required	require	VBN
cord-272051-arz8r204	213	14	for	for	IN
cord-272051-arz8r204	213	15	viral	viral	JJ
cord-272051-arz8r204	213	16	fusion	fusion	NN
cord-272051-arz8r204	213	17	.	.	.
cord-272051-arz8r204	214	1	The	the	DT
cord-272051-arz8r204	214	2	concept	concept	NN
cord-272051-arz8r204	214	3	that	that	IN
cord-272051-arz8r204	214	4	the	the	DT
cord-272051-arz8r204	214	5	activity	activity	NN
cord-272051-arz8r204	214	6	of	of	IN
cord-272051-arz8r204	214	7	cell	cell	NN
cord-272051-arz8r204	214	8	proteases	protease	NNS
cord-272051-arz8r204	214	9	is	be	VBZ
cord-272051-arz8r204	214	10	part	part	NN
cord-272051-arz8r204	214	11	of	of	IN
cord-272051-arz8r204	214	12	the	the	DT
cord-272051-arz8r204	214	13	mechanisms	mechanism	NNS
cord-272051-arz8r204	214	14	underlying	underlie	VBG
cord-272051-arz8r204	214	15	the	the	DT
cord-272051-arz8r204	214	16	replication	replication	NN
cord-272051-arz8r204	214	17	of	of	IN
cord-272051-arz8r204	214	18	many	many	JJ
cord-272051-arz8r204	214	19	virus	virus	NN
cord-272051-arz8r204	214	20	species	species	NN
cord-272051-arz8r204	214	21	is	be	VBZ
cord-272051-arz8r204	214	22	widely	widely	RB
cord-272051-arz8r204	214	23	accepted	accept	VBN
cord-272051-arz8r204	214	24	.	.	.
cord-272051-arz8r204	215	1	For	for	IN
cord-272051-arz8r204	215	2	example	example	NN
cord-272051-arz8r204	215	3	,	,	,
cord-272051-arz8r204	215	4	the	the	DT
cord-272051-arz8r204	215	5	cleavage	cleavage	NN
cord-272051-arz8r204	215	6	of	of	IN
cord-272051-arz8r204	215	7	HA	HA	NNP
cord-272051-arz8r204	215	8	generated	generate	VBN
cord-272051-arz8r204	215	9	by	by	IN
cord-272051-arz8r204	215	10	cell	cell	NN
cord-272051-arz8r204	215	11	proteases	protease	NNS
cord-272051-arz8r204	215	12	is	be	VBZ
cord-272051-arz8r204	215	13	required	require	VBN
cord-272051-arz8r204	215	14	for	for	IN
cord-272051-arz8r204	215	15	the	the	DT
cord-272051-arz8r204	215	16	activation	activation	NN
cord-272051-arz8r204	215	17	of	of	IN
cord-272051-arz8r204	215	18	the	the	DT
cord-272051-arz8r204	215	19	viral	viral	JJ
cord-272051-arz8r204	215	20	envelope	envelope	NN
cord-272051-arz8r204	215	21	protein	protein	NN
cord-272051-arz8r204	215	22	preceding	precede	VBG
cord-272051-arz8r204	215	23	the	the	DT
cord-272051-arz8r204	215	24	viral	viral	JJ
cord-272051-arz8r204	215	25	fusion	fusion	NN
cord-272051-arz8r204	215	26	of	of	IN
cord-272051-arz8r204	215	27	influenza	influenza	NN
cord-272051-arz8r204	215	28	virus	virus	NN
cord-272051-arz8r204	215	29	(	(	-LRB-
cord-272051-arz8r204	215	30	Klenk	Klenk	NNP
cord-272051-arz8r204	215	31	et	et	FW
cord-272051-arz8r204	215	32	al	al	NNP
cord-272051-arz8r204	215	33	.	.	.
cord-272051-arz8r204	216	1	,	,	,
cord-272051-arz8r204	216	2	1975	1975	CD
cord-272051-arz8r204	216	3	;	;	:
cord-272051-arz8r204	216	4	Lazarowitz	Lazarowitz	NNP
cord-272051-arz8r204	216	5	and	and	CC
cord-272051-arz8r204	216	6	Choppin	Choppin	NNP
cord-272051-arz8r204	216	7	,	,	,
cord-272051-arz8r204	216	8	1975	1975	CD
cord-272051-arz8r204	216	9	)	)	-RRB-
cord-272051-arz8r204	216	10	.	.	.
cord-272051-arz8r204	217	1	Similarly	similarly	RB
cord-272051-arz8r204	217	2	,	,	,
cord-272051-arz8r204	217	3	the	the	DT
cord-272051-arz8r204	217	4	activation	activation	NN
cord-272051-arz8r204	217	5	of	of	IN
cord-272051-arz8r204	217	6	envelope	envelope	NN
cord-272051-arz8r204	217	7	proteins	protein	NNS
cord-272051-arz8r204	217	8	of	of	IN
cord-272051-arz8r204	217	9	Ebola	Ebola	NNP
cord-272051-arz8r204	217	10	(	(	-LRB-
cord-272051-arz8r204	217	11	Schornberg	Schornberg	NNP
cord-272051-arz8r204	217	12	et	et	FW
cord-272051-arz8r204	217	13	al	al	NNP
cord-272051-arz8r204	217	14	.	.	NNP
cord-272051-arz8r204	217	15	,	,	,
cord-272051-arz8r204	217	16	2006	2006	CD
cord-272051-arz8r204	217	17	)	)	-RRB-
cord-272051-arz8r204	217	18	,	,	,
cord-272051-arz8r204	217	19	Nipah	Nipah	NNP
cord-272051-arz8r204	217	20	(	(	-LRB-
cord-272051-arz8r204	217	21	Pager	Pager	NNP
cord-272051-arz8r204	217	22	and	and	CC
cord-272051-arz8r204	217	23	Dutch	Dutch	NNP
cord-272051-arz8r204	217	24	,	,	,
cord-272051-arz8r204	217	25	2005	2005	CD
cord-272051-arz8r204	217	26	)	)	-RRB-
cord-272051-arz8r204	217	27	,	,	,
cord-272051-arz8r204	217	28	and	and	CC
cord-272051-arz8r204	217	29	Corona	Corona	NNP
cord-272051-arz8r204	217	30	viruses	virus	NNS
cord-272051-arz8r204	217	31	(	(	-LRB-
cord-272051-arz8r204	217	32	Bosch	Bosch	NNP
cord-272051-arz8r204	217	33	et	et	NNP
cord-272051-arz8r204	217	34	al	al	NNP
cord-272051-arz8r204	217	35	.	.	NNP
cord-272051-arz8r204	217	36	,	,	,
cord-272051-arz8r204	217	37	2008	2008	CD
cord-272051-arz8r204	217	38	)	)	-RRB-
cord-272051-arz8r204	217	39	is	be	VBZ
cord-272051-arz8r204	217	40	regulated	regulate	VBN
cord-272051-arz8r204	217	41	by	by	IN
cord-272051-arz8r204	217	42	cathepsins	cathepsin	NNS
cord-272051-arz8r204	217	43	,	,	,
cord-272051-arz8r204	217	44	i.e.	i.e.	FW
cord-272051-arz8r204	217	45	,	,	,
cord-272051-arz8r204	217	46	a	a	DT
cord-272051-arz8r204	217	47	family	family	NN
cord-272051-arz8r204	217	48	of	of	IN
cord-272051-arz8r204	217	49	cell	cell	NN
cord-272051-arz8r204	217	50	aspartyl	aspartyl	NNP
cord-272051-arz8r204	217	51	-	-	HYPH
cord-272051-arz8r204	217	52	proteases	protease	NNS
cord-272051-arz8r204	217	53	.	.	.
cord-272051-arz8r204	218	1	The	the	DT
cord-272051-arz8r204	218	2	identification	identification	NN
cord-272051-arz8r204	218	3	of	of	IN
cord-272051-arz8r204	218	4	host	host	NN
cord-272051-arz8r204	218	5	factors	factor	NNS
cord-272051-arz8r204	218	6	,	,	,
cord-272051-arz8r204	218	7	in	in	IN
cord-272051-arz8r204	218	8	particular	particular	JJ
cord-272051-arz8r204	218	9	aspartyl	aspartyl	NN
cord-272051-arz8r204	218	10	-	-	HYPH
cord-272051-arz8r204	218	11	proteases	protease	NNS
cord-272051-arz8r204	218	12	,	,	,
cord-272051-arz8r204	218	13	involved	involve	VBN
cord-272051-arz8r204	218	14	in	in	IN
cord-272051-arz8r204	218	15	the	the	DT
cord-272051-arz8r204	218	16	here	here	RB
cord-272051-arz8r204	218	17	described	describe	VBN
cord-272051-arz8r204	218	18	PI	pi	NN
cord-272051-arz8r204	218	19	-	-	HYPH
cord-272051-arz8r204	218	20	induced	induce	VBN
cord-272051-arz8r204	218	21	inhibition	inhibition	NN
cord-272051-arz8r204	218	22	of	of	IN
cord-272051-arz8r204	218	23	viral	viral	JJ
cord-272051-arz8r204	218	24	entry	entry	NN
cord-272051-arz8r204	218	25	deserves	deserve	VBZ
cord-272051-arz8r204	218	26	further	further	JJ
cord-272051-arz8r204	218	27	investigations	investigation	NNS
cord-272051-arz8r204	218	28	.	.	.
cord-272051-arz8r204	219	1	The	the	DT
cord-272051-arz8r204	219	2	results	result	NNS
cord-272051-arz8r204	219	3	from	from	IN
cord-272051-arz8r204	219	4	functional	functional	JJ
cord-272051-arz8r204	219	5	genetic	genetic	JJ
cord-272051-arz8r204	219	6	screens	screen	NNS
cord-272051-arz8r204	219	7	have	have	VBP
cord-272051-arz8r204	219	8	demonstrated	demonstrate	VBN
cord-272051-arz8r204	219	9	that	that	IN
cord-272051-arz8r204	219	10	alternative	alternative	JJ
cord-272051-arz8r204	219	11	cell	cell	NN
cord-272051-arz8r204	219	12	proteases	protease	NNS
cord-272051-arz8r204	219	13	act	act	VBP
cord-272051-arz8r204	219	14	as	as	IN
cord-272051-arz8r204	219	15	co	co	NNS
cord-272051-arz8r204	219	16	-	-	NNS
cord-272051-arz8r204	219	17	factors	factor	NNS
cord-272051-arz8r204	219	18	in	in	IN
cord-272051-arz8r204	219	19	the	the	DT
cord-272051-arz8r204	219	20	replication	replication	NN
cord-272051-arz8r204	219	21	of	of	IN
cord-272051-arz8r204	219	22	different	different	JJ
cord-272051-arz8r204	219	23	viruses	virus	NNS
cord-272051-arz8r204	219	24	Clemente	Clemente	NNP
cord-272051-arz8r204	219	25	et	et	NNP
cord-272051-arz8r204	219	26	al	al	NNP
cord-272051-arz8r204	219	27	.	.	NNP
cord-272051-arz8r204	219	28	,	,	,
cord-272051-arz8r204	219	29	2010	2010	CD
cord-272051-arz8r204	219	30	;	;	:
cord-272051-arz8r204	219	31	Hao	Hao	NNP
cord-272051-arz8r204	219	32	et	et	NNP
cord-272051-arz8r204	219	33	al	al	NNP
cord-272051-arz8r204	219	34	.	.	NNP
cord-272051-arz8r204	219	35	,	,	,
cord-272051-arz8r204	219	36	2008	2008	CD
cord-272051-arz8r204	219	37	;	;	:
cord-272051-arz8r204	219	38	Krishnan	Krishnan	NNP
cord-272051-arz8r204	219	39	et	et	NNP
cord-272051-arz8r204	219	40	al	al	NNP
cord-272051-arz8r204	219	41	.	.	NNP
cord-272051-arz8r204	219	42	,	,	,
cord-272051-arz8r204	219	43	2008	2008	CD
cord-272051-arz8r204	219	44	;	;	.
cord-272051-arz8r204	220	1	Ng	Ng	NNP
cord-272051-arz8r204	220	2	et	et	FW
cord-272051-arz8r204	220	3	al	al	NNP
cord-272051-arz8r204	220	4	.	.	NNP
cord-272051-arz8r204	220	5	,	,	,
cord-272051-arz8r204	220	6	2007	2007	CD
cord-272051-arz8r204	221	1	;	;	:
cord-272051-arz8r204	221	2	Nguyen	Nguyen	NNP
cord-272051-arz8r204	221	3	et	et	NNP
cord-272051-arz8r204	221	4	al	al	NNP
cord-272051-arz8r204	221	5	.	.	NNP
cord-272051-arz8r204	221	6	,	,	,
cord-272051-arz8r204	221	7	2006	2006	CD
cord-272051-arz8r204	221	8	;	;	:
cord-272051-arz8r204	221	9	Pelkmans	Pelkmans	NNP
cord-272051-arz8r204	221	10	et	et	NNP
cord-272051-arz8r204	221	11	al	al	NNP
cord-272051-arz8r204	221	12	.	.	NNP
cord-272051-arz8r204	221	13	,	,	,
cord-272051-arz8r204	221	14	2005	2005	CD
cord-272051-arz8r204	221	15	)	)	-RRB-
cord-272051-arz8r204	221	16	.	.	.
cord-272051-arz8r204	222	1	Concerning	concern	VBG
cord-272051-arz8r204	222	2	VSV	VSV	NNP
cord-272051-arz8r204	222	3	,	,	,
cord-272051-arz8r204	222	4	the	the	DT
cord-272051-arz8r204	222	5	comparison	comparison	NN
cord-272051-arz8r204	222	6	of	of	IN
cord-272051-arz8r204	222	7	these	these	DT
cord-272051-arz8r204	222	8	data	datum	NNS
cord-272051-arz8r204	222	9	with	with	IN
cord-272051-arz8r204	222	10	those	those	DT
cord-272051-arz8r204	222	11	regarding	regard	VBG
cord-272051-arz8r204	222	12	the	the	DT
cord-272051-arz8r204	222	13	cell	cell	NN
cord-272051-arz8r204	222	14	proteases	protease	NNS
cord-272051-arz8r204	222	15	known	know	VBN
cord-272051-arz8r204	222	16	to	to	TO
cord-272051-arz8r204	222	17	be	be	VB
cord-272051-arz8r204	222	18	sensitive	sensitive	JJ
cord-272051-arz8r204	222	19	to	to	IN
cord-272051-arz8r204	222	20	PIs	PIs	NNP
cord-272051-arz8r204	222	21	identifies	identify	VBZ
cord-272051-arz8r204	222	22	both	both	DT
cord-272051-arz8r204	222	23	proteasome	proteasome	NN
cord-272051-arz8r204	222	24	subunits	subunit	NNS
cord-272051-arz8r204	222	25	as	as	IN
cord-272051-arz8r204	222	26	possible	possible	JJ
cord-272051-arz8r204	222	27	relevant	relevant	JJ
cord-272051-arz8r204	222	28	PI	pi	NN
cord-272051-arz8r204	222	29	targets	target	NNS
cord-272051-arz8r204	223	1	(	(	-LRB-
cord-272051-arz8r204	223	2	Clemente	Clemente	NNP
cord-272051-arz8r204	223	3	et	et	NNP
cord-272051-arz8r204	223	4	al	al	NNP
cord-272051-arz8r204	223	5	.	.	NNP
cord-272051-arz8r204	223	6	,	,	,
cord-272051-arz8r204	223	7	2010	2010	CD
cord-272051-arz8r204	223	8	)	)	-RRB-
cord-272051-arz8r204	223	9	.	.	.
cord-272051-arz8r204	224	1	This	this	DT
cord-272051-arz8r204	224	2	appears	appear	VBZ
cord-272051-arz8r204	224	3	consistent	consistent	JJ
cord-272051-arz8r204	224	4	with	with	IN
cord-272051-arz8r204	224	5	the	the	DT
cord-272051-arz8r204	224	6	recently	recently	RB
cord-272051-arz8r204	224	7	reported	report	VBN
cord-272051-arz8r204	224	8	evidence	evidence	NN
cord-272051-arz8r204	224	9	that	that	IN
cord-272051-arz8r204	224	10	MG132	mg132	NN
cord-272051-arz8r204	224	11	(	(	-LRB-
cord-272051-arz8r204	224	12	i.e.	i.e.	FW
cord-272051-arz8r204	224	13	,	,	,
cord-272051-arz8r204	224	14	a	a	DT
cord-272051-arz8r204	224	15	proteasome	proteasome	VBN
cord-272051-arz8r204	224	16	inhibitor	inhibitor	NN
cord-272051-arz8r204	224	17	)	)	-RRB-
cord-272051-arz8r204	224	18	inhibits	inhibit	VBZ
cord-272051-arz8r204	224	19	VSV	VSV	NNP
cord-272051-arz8r204	224	20	replication	replication	NN
cord-272051-arz8r204	224	21	(	(	-LRB-
cord-272051-arz8r204	224	22	Neznanov	Neznanov	NNP
cord-272051-arz8r204	224	23	et	et	NNP
cord-272051-arz8r204	224	24	al	al	NNP
cord-272051-arz8r204	224	25	.	.	NNP
cord-272051-arz8r204	224	26	,	,	,
cord-272051-arz8r204	224	27	2008	2008	CD
cord-272051-arz8r204	224	28	)	)	-RRB-
cord-272051-arz8r204	224	29	.	.	.
cord-272051-arz8r204	225	1	Alternative	alternative	JJ
cord-272051-arz8r204	225	2	functional	functional	JJ
cord-272051-arz8r204	225	3	genetic	genetic	JJ
cord-272051-arz8r204	225	4	screens	screen	NNS
cord-272051-arz8r204	225	5	revealed	reveal	VBD
cord-272051-arz8r204	225	6	that	that	IN
cord-272051-arz8r204	225	7	also	also	RB
cord-272051-arz8r204	225	8	MMP-21	MMP-21	NNP
cord-272051-arz8r204	225	9	could	could	MD
cord-272051-arz8r204	225	10	be	be	VB
cord-272051-arz8r204	225	11	part	part	NN
cord-272051-arz8r204	225	12	of	of	IN
cord-272051-arz8r204	225	13	the	the	DT
cord-272051-arz8r204	225	14	mechanism	mechanism	NN
cord-272051-arz8r204	225	15	of	of	IN
cord-272051-arz8r204	225	16	VSV	VSV	NNP
cord-272051-arz8r204	225	17	replication	replication	NN
cord-272051-arz8r204	225	18	(	(	-LRB-
cord-272051-arz8r204	226	1	Clemente	Clemente	NNP
cord-272051-arz8r204	226	2	et	et	NNP
cord-272051-arz8r204	226	3	al	al	NNP
cord-272051-arz8r204	226	4	.	.	NNP
cord-272051-arz8r204	226	5	,	,	,
cord-272051-arz8r204	226	6	2010	2010	CD
cord-272051-arz8r204	226	7	)	)	-RRB-
cord-272051-arz8r204	226	8	.	.	.
cord-272051-arz8r204	227	1	Considering	consider	VBG
cord-272051-arz8r204	227	2	that	that	IN
cord-272051-arz8r204	227	3	the	the	DT
cord-272051-arz8r204	227	4	activity	activity	NN
cord-272051-arz8r204	227	5	of	of	IN
cord-272051-arz8r204	227	6	MMP-21	MMP-21	NNP
cord-272051-arz8r204	227	7	,	,	,
cord-272051-arz8r204	227	8	like	like	IN
cord-272051-arz8r204	227	9	other	other	JJ
cord-272051-arz8r204	227	10	MMPs	mmp	NNS
cord-272051-arz8r204	227	11	,	,	,
cord-272051-arz8r204	227	12	might	may	MD
cord-272051-arz8r204	227	13	be	be	VB
cord-272051-arz8r204	227	14	affected	affect	VBN
cord-272051-arz8r204	227	15	by	by	IN
cord-272051-arz8r204	227	16	PIs	pi	NNS
cord-272051-arz8r204	227	17	,	,	,
cord-272051-arz8r204	227	18	it	-PRON-	PRP
cord-272051-arz8r204	227	19	would	would	MD
cord-272051-arz8r204	227	20	be	be	VB
cord-272051-arz8r204	227	21	of	of	IN
cord-272051-arz8r204	227	22	interest	interest	NN
cord-272051-arz8r204	227	23	investigating	investigate	VBG
cord-272051-arz8r204	227	24	the	the	DT
cord-272051-arz8r204	227	25	role	role	NN
cord-272051-arz8r204	227	26	of	of	IN
cord-272051-arz8r204	227	27	this	this	DT
cord-272051-arz8r204	227	28	MMP	MMP	NNP
cord-272051-arz8r204	227	29	in	in	IN
cord-272051-arz8r204	227	30	the	the	DT
cord-272051-arz8r204	227	31	here	here	RB
cord-272051-arz8r204	227	32	described	describe	VBN
cord-272051-arz8r204	227	33	antiviral	antiviral	JJ
cord-272051-arz8r204	227	34	effect	effect	NN
cord-272051-arz8r204	227	35	of	of	IN
cord-272051-arz8r204	227	36	PIs	pi	NNS
cord-272051-arz8r204	227	37	.	.	.
cord-272051-arz8r204	228	1	The	the	DT
cord-272051-arz8r204	228	2	here	here	RB
cord-272051-arz8r204	228	3	reported	report	VBN
cord-272051-arz8r204	228	4	findings	finding	NNS
cord-272051-arz8r204	228	5	would	would	MD
cord-272051-arz8r204	228	6	open	open	VB
cord-272051-arz8r204	228	7	the	the	DT
cord-272051-arz8r204	228	8	way	way	NN
cord-272051-arz8r204	228	9	towards	towards	IN
cord-272051-arz8r204	228	10	preclinical	preclinical	JJ
cord-272051-arz8r204	228	11	assays	assay	NNS
cord-272051-arz8r204	228	12	designed	design	VBN
cord-272051-arz8r204	228	13	to	to	TO
cord-272051-arz8r204	228	14	test	test	VB
cord-272051-arz8r204	228	15	the	the	DT
cord-272051-arz8r204	228	16	potency	potency	NN
cord-272051-arz8r204	228	17	of	of	IN
cord-272051-arz8r204	228	18	PIs	pi	NNS
cord-272051-arz8r204	228	19	against	against	IN
cord-272051-arz8r204	228	20	in	in	IN
cord-272051-arz8r204	228	21	vivo	vivo	NN
cord-272051-arz8r204	228	22	infections	infection	NNS
cord-272051-arz8r204	228	23	sustained	sustain	VBN
cord-272051-arz8r204	228	24	by	by	IN
cord-272051-arz8r204	228	25	Orthomyxo	Orthomyxo	NNP
cord-272051-arz8r204	228	26	-	-	:
cord-272051-arz8r204	228	27	and	and	CC
cord-272051-arz8r204	228	28	Rabies	Rabies	NNP
cord-272051-arz8r204	228	29	viruses	virus	NNS
cord-272051-arz8r204	228	30	.	.	.
cord-272051-arz8r204	229	1	It	-PRON-	PRP
cord-272051-arz8r204	229	2	will	will	MD
cord-272051-arz8r204	229	3	be	be	VB
cord-272051-arz8r204	229	4	also	also	RB
cord-272051-arz8r204	229	5	of	of	IN
cord-272051-arz8r204	229	6	interest	interest	NN
cord-272051-arz8r204	229	7	extending	extend	VBG
cord-272051-arz8r204	229	8	the	the	DT
cord-272051-arz8r204	229	9	investigations	investigation	NNS
cord-272051-arz8r204	229	10	on	on	IN
cord-272051-arz8r204	229	11	additional	additional	JJ
cord-272051-arz8r204	229	12	pathogenic	pathogenic	JJ
cord-272051-arz8r204	229	13	enveloped	envelop	VBN
cord-272051-arz8r204	229	14	viruses	virus	NNS
cord-272051-arz8r204	229	15	infecting	infect	VBG
cord-272051-arz8r204	229	16	by	by	IN
cord-272051-arz8r204	229	17	endocytosis	endocytosis	NN
cord-272051-arz8r204	229	18	.	.	.
cord-272051-arz8r204	230	1	VSV	VSV	NNP
cord-272051-arz8r204	230	2	-	-	HYPH
cord-272051-arz8r204	230	3	G	G	NNP
cord-272051-arz8r204	230	4	pseudotyped	pseudotype	VBD
cord-272051-arz8r204	230	5	HIV-1	HIV-1	NNP
cord-272051-arz8r204	230	6	preparations	preparation	NNS
cord-272051-arz8r204	230	7	were	be	VBD
cord-272051-arz8r204	230	8	obtained	obtain	VBN
cord-272051-arz8r204	230	9	from	from	IN
cord-272051-arz8r204	230	10	supernatants	supernatant	NNS
cord-272051-arz8r204	230	11	of	of	IN
cord-272051-arz8r204	230	12	293	293	CD
cord-272051-arz8r204	230	13	T	t	NN
cord-272051-arz8r204	230	14	cells	cell	NNS
cord-272051-arz8r204	230	15	48	48	CD
cord-272051-arz8r204	230	16	h	h	NN
cord-272051-arz8r204	230	17	after	after	IN
cord-272051-arz8r204	230	18	co	co	NN
cord-272051-arz8r204	230	19	-	-	NN
cord-272051-arz8r204	230	20	transfection	transfection	NN
cord-272051-arz8r204	230	21	with	with	IN
cord-272051-arz8r204	230	22	a	a	DT
cord-272051-arz8r204	230	23	CMV	CMV	NNP
cord-272051-arz8r204	230	24	immediate	immediate	JJ
cord-272051-arz8r204	230	25	-	-	HYPH
cord-272051-arz8r204	230	26	early	early	RB
cord-272051-arz8r204	230	27	promoted	promote	VBN
cord-272051-arz8r204	230	28	VSV	VSV	NNP
cord-272051-arz8r204	230	29	-	-	HYPH
cord-272051-arz8r204	230	30	G	G	NNP
cord-272051-arz8r204	230	31	-	-	HYPH
cord-272051-arz8r204	230	32	expressing	express	VBG
cord-272051-arz8r204	230	33	vector	vector	NN
cord-272051-arz8r204	230	34	and	and	CC
cord-272051-arz8r204	230	35	vectors	vector	NNS
cord-272051-arz8r204	230	36	expressing	express	VBG
cord-272051-arz8r204	230	37	NL4	nl4	JJ
cord-272051-arz8r204	230	38	-	-	HYPH
cord-272051-arz8r204	230	39	3	3	CD
cord-272051-arz8r204	230	40	HIV-1	HIV-1	NNP
cord-272051-arz8r204	230	41	,	,	,
cord-272051-arz8r204	230	42	its	-PRON-	PRP$
cord-272051-arz8r204	230	43	Δenv	Δenv	NNP
cord-272051-arz8r204	230	44	derivative	derivative	NN
cord-272051-arz8r204	230	45	,	,	,
cord-272051-arz8r204	230	46	or	or	CC
cord-272051-arz8r204	230	47	PM4	PM4	NNP
cord-272051-arz8r204	230	48	HIV-1	HIV-1	NNP
cord-272051-arz8r204	230	49	(	(	-LRB-
cord-272051-arz8r204	230	50	molar	molar	JJ
cord-272051-arz8r204	230	51	ratio	ratio	NN
cord-272051-arz8r204	230	52	1:5	1:5	CD
cord-272051-arz8r204	230	53	)	)	-RRB-
cord-272051-arz8r204	230	54	performed	perform	VBN
cord-272051-arz8r204	230	55	by	by	IN
cord-272051-arz8r204	230	56	the	the	DT
cord-272051-arz8r204	230	57	Lipofectamine	Lipofectamine	NNP
cord-272051-arz8r204	230	58	2000-based	2000-based	CD
cord-272051-arz8r204	230	59	method	method	NN
cord-272051-arz8r204	230	60	(	(	-LRB-
cord-272051-arz8r204	230	61	Invitrogen	Invitrogen	NNP
cord-272051-arz8r204	230	62	)	)	-RRB-
cord-272051-arz8r204	230	63	.	.	.
cord-272051-arz8r204	231	1	Supernatants	supernatant	NNS
cord-272051-arz8r204	231	2	were	be	VBD
cord-272051-arz8r204	231	3	clarified	clarify	VBN
cord-272051-arz8r204	231	4	and	and	CC
cord-272051-arz8r204	231	5	concentrated	concentrate	VBN
cord-272051-arz8r204	231	6	by	by	IN
cord-272051-arz8r204	231	7	ultracentrifugation	ultracentrifugation	NN
cord-272051-arz8r204	231	8	as	as	IN
cord-272051-arz8r204	231	9	described	describe	VBN
cord-272051-arz8r204	231	10	(	(	-LRB-
cord-272051-arz8r204	231	11	Federico	Federico	NNP
cord-272051-arz8r204	231	12	et	et	NNP
cord-272051-arz8r204	231	13	al	al	NNP
cord-272051-arz8r204	231	14	.	.	NNP
cord-272051-arz8r204	231	15	,	,	,
cord-272051-arz8r204	231	16	2001	2001	CD
cord-272051-arz8r204	231	17	)	)	-RRB-
cord-272051-arz8r204	231	18	.	.	.
cord-272051-arz8r204	232	1	Virus	virus	NN
cord-272051-arz8r204	232	2	preparations	preparation	NNS
cord-272051-arz8r204	232	3	were	be	VBD
cord-272051-arz8r204	232	4	titrated	titrate	VBN
cord-272051-arz8r204	232	5	by	by	IN
cord-272051-arz8r204	232	6	measuring	measure	VBG
cord-272051-arz8r204	232	7	HIV-1	HIV-1	NNP
cord-272051-arz8r204	232	8	CAp24	cap24	IN
cord-272051-arz8r204	232	9	contents	content	NNS
cord-272051-arz8r204	232	10	by	by	IN
cord-272051-arz8r204	232	11	quantitative	quantitative	JJ
cord-272051-arz8r204	232	12	enzyme	enzyme	NN
cord-272051-arz8r204	232	13	-	-	HYPH
cord-272051-arz8r204	232	14	linked	link	VBN
cord-272051-arz8r204	232	15	immunosorbent	immunosorbent	JJ
cord-272051-arz8r204	232	16	assay	assay	NN
cord-272051-arz8r204	232	17	(	(	-LRB-
cord-272051-arz8r204	232	18	ELISA	ELISA	NNP
cord-272051-arz8r204	232	19	;	;	:
cord-272051-arz8r204	232	20	Innogenetic	Innogenetic	NNP
cord-272051-arz8r204	232	21	)	)	-RRB-
cord-272051-arz8r204	232	22	.	.	.
cord-272051-arz8r204	233	1	Both	both	DT
cord-272051-arz8r204	233	2	preparations	preparation	NNS
cord-272051-arz8r204	233	3	and	and	CC
cord-272051-arz8r204	233	4	assays	assay	NNS
cord-272051-arz8r204	233	5	of	of	IN
cord-272051-arz8r204	233	6	VSV	VSV	NNP
cord-272051-arz8r204	233	7	(	(	-LRB-
cord-272051-arz8r204	233	8	Indiana	Indiana	NNP
cord-272051-arz8r204	233	9	strain	strain	NN
cord-272051-arz8r204	233	10	)	)	-RRB-
cord-272051-arz8r204	233	11	have	have	VBP
cord-272051-arz8r204	233	12	been	be	VBN
cord-272051-arz8r204	233	13	performed	perform	VBN
cord-272051-arz8r204	233	14	basically	basically	RB
cord-272051-arz8r204	233	15	as	as	IN
cord-272051-arz8r204	233	16	described	describe	VBN
cord-272051-arz8r204	233	17	(	(	-LRB-
cord-272051-arz8r204	233	18	Gresser	Gresser	NNP
cord-272051-arz8r204	233	19	et	et	NNP
cord-272051-arz8r204	233	20	al	al	NNP
cord-272051-arz8r204	233	21	.	.	NNP
cord-272051-arz8r204	233	22	,	,	,
cord-272051-arz8r204	233	23	1968	1968	CD
cord-272051-arz8r204	233	24	)	)	-RRB-
cord-272051-arz8r204	233	25	.	.	.
cord-272051-arz8r204	234	1	Briefly	briefly	RB
cord-272051-arz8r204	234	2	,	,	,
cord-272051-arz8r204	234	3	high	high	JJ
cord-272051-arz8r204	234	4	titer	titer	NN
cord-272051-arz8r204	234	5	stocks	stock	NNS
cord-272051-arz8r204	234	6	of	of	IN
cord-272051-arz8r204	234	7	VSV	VSV	NNP
cord-272051-arz8r204	234	8	have	have	VBP
cord-272051-arz8r204	234	9	been	be	VBN
cord-272051-arz8r204	234	10	prepared	prepare	VBN
cord-272051-arz8r204	234	11	upon	upon	IN
cord-272051-arz8r204	234	12	infection	infection	NN
cord-272051-arz8r204	234	13	of	of	IN
cord-272051-arz8r204	234	14	HeLa	HeLa	NNP
cord-272051-arz8r204	234	15	cells	cell	NNS
cord-272051-arz8r204	234	16	with	with	IN
cord-272051-arz8r204	234	17	at	at	IN
cord-272051-arz8r204	234	18	low	low	JJ
cord-272051-arz8r204	234	19	multiplicity	multiplicity	NN
cord-272051-arz8r204	234	20	of	of	IN
cord-272051-arz8r204	234	21	infection	infection	NN
cord-272051-arz8r204	234	22	(	(	-LRB-
cord-272051-arz8r204	234	23	m.o.i	m.o.i	NNP
cord-272051-arz8r204	234	24	.	.	NNP
cord-272051-arz8r204	234	25	)	)	-RRB-
cord-272051-arz8r204	234	26	,	,	,
cord-272051-arz8r204	234	27	i.e.	i.e.	FW
cord-272051-arz8r204	234	28	b0.01	b0.01	JJ
cord-272051-arz8r204	234	29	plaque	plaque	NN
cord-272051-arz8r204	234	30	forming	form	VBG
cord-272051-arz8r204	234	31	unit	unit	NN
cord-272051-arz8r204	234	32	(	(	-LRB-
cord-272051-arz8r204	234	33	PFU)/cell	PFU)/cell	NNP
cord-272051-arz8r204	234	34	.	.	.
cord-272051-arz8r204	235	1	Supernatants	supernatant	NNS
cord-272051-arz8r204	235	2	were	be	VBD
cord-272051-arz8r204	235	3	harvested	harvest	VBN
cord-272051-arz8r204	235	4	24	24	CD
cord-272051-arz8r204	235	5	h	h	NN
cord-272051-arz8r204	235	6	later	later	RB
cord-272051-arz8r204	235	7	,	,	,
cord-272051-arz8r204	235	8	clarified	clarify	VBN
cord-272051-arz8r204	235	9	,	,	,
cord-272051-arz8r204	235	10	stocked	stock	VBN
cord-272051-arz8r204	235	11	,	,	,
cord-272051-arz8r204	235	12	and	and	CC
cord-272051-arz8r204	235	13	frozen	frozen	JJ
cord-272051-arz8r204	235	14	.	.	.
cord-272051-arz8r204	236	1	VSV	VSV	NNP
cord-272051-arz8r204	236	2	titrations	titration	NNS
cord-272051-arz8r204	236	3	of	of	IN
cord-272051-arz8r204	236	4	high	high	JJ
cord-272051-arz8r204	236	5	titer	titer	NN
cord-272051-arz8r204	236	6	stocks	stock	NNS
cord-272051-arz8r204	236	7	have	have	VBP
cord-272051-arz8r204	236	8	been	be	VBN
cord-272051-arz8r204	236	9	carried	carry	VBN
cord-272051-arz8r204	236	10	out	out	RP
cord-272051-arz8r204	236	11	by	by	IN
cord-272051-arz8r204	236	12	plaque	plaque	NN
cord-272051-arz8r204	236	13	method	method	NN
cord-272051-arz8r204	236	14	.	.	.
cord-272051-arz8r204	237	1	The	the	DT
cord-272051-arz8r204	237	2	A	A	NNP
cord-272051-arz8r204	237	3	/	/	SYM
cord-272051-arz8r204	237	4	Puerto	Puerto	NNP
cord-272051-arz8r204	237	5	Rico	Rico	NNP
cord-272051-arz8r204	237	6	(	(	-LRB-
cord-272051-arz8r204	237	7	PR)/8/34	pr)/8/34	NN
cord-272051-arz8r204	237	8	H	h	NN
cord-272051-arz8r204	237	9	1	1	CD
cord-272051-arz8r204	237	10	N	n	CD
cord-272051-arz8r204	237	11	1	1	CD
cord-272051-arz8r204	237	12	human	human	JJ
cord-272051-arz8r204	237	13	influenza	influenza	NN
cord-272051-arz8r204	237	14	virus	virus	NN
cord-272051-arz8r204	237	15	was	be	VBD
cord-272051-arz8r204	237	16	grown	grow	VBN
cord-272051-arz8r204	237	17	in	in	IN
cord-272051-arz8r204	237	18	11-day	11-day	CD
cord-272051-arz8r204	237	19	-	-	HYPH
cord-272051-arz8r204	237	20	old	old	JJ
cord-272051-arz8r204	237	21	embryonated	embryonate	VBN
cord-272051-arz8r204	237	22	chicken	chicken	NN
cord-272051-arz8r204	237	23	eggs	egg	NNS
cord-272051-arz8r204	237	24	.	.	.
cord-272051-arz8r204	238	1	The	the	DT
cord-272051-arz8r204	238	2	allantoic	allantoic	NNP
cord-272051-arz8r204	238	3	fluid	fluid	NN
cord-272051-arz8r204	238	4	was	be	VBD
cord-272051-arz8r204	238	5	clarified	clarify	VBN
cord-272051-arz8r204	238	6	by	by	IN
cord-272051-arz8r204	238	7	centrifugation	centrifugation	NN
cord-272051-arz8r204	238	8	at	at	IN
cord-272051-arz8r204	238	9	5000×g	5000×g	CD
cord-272051-arz8r204	238	10	for	for	IN
cord-272051-arz8r204	238	11	15	15	CD
cord-272051-arz8r204	238	12	min	min	NN
cord-272051-arz8r204	238	13	at	at	IN
cord-272051-arz8r204	238	14	4	4	CD
cord-272051-arz8r204	238	15	°	°	NN
cord-272051-arz8r204	238	16	C	c	NN
cord-272051-arz8r204	238	17	.	.	.
cord-272051-arz8r204	239	1	The	the	DT
cord-272051-arz8r204	239	2	virus	virus	NN
cord-272051-arz8r204	239	3	was	be	VBD
cord-272051-arz8r204	239	4	pelleted	pellete	VBN
cord-272051-arz8r204	239	5	by	by	IN
cord-272051-arz8r204	239	6	centrifugation	centrifugation	NN
cord-272051-arz8r204	239	7	at	at	IN
cord-272051-arz8r204	239	8	65,000×g	65,000×g	CD
cord-272051-arz8r204	239	9	for	for	IN
cord-272051-arz8r204	239	10	1	1	CD
cord-272051-arz8r204	239	11	h	h	NN
cord-272051-arz8r204	239	12	at	at	IN
cord-272051-arz8r204	239	13	4	4	CD
cord-272051-arz8r204	239	14	°	°	NN
cord-272051-arz8r204	239	15	C	c	NN
cord-272051-arz8r204	239	16	and	and	CC
cord-272051-arz8r204	239	17	resuspended	resuspend	VBD
cord-272051-arz8r204	239	18	in	in	IN
cord-272051-arz8r204	239	19	1	1	CD
cord-272051-arz8r204	239	20	ml	ml	NNS
cord-272051-arz8r204	239	21	of	of	IN
cord-272051-arz8r204	239	22	phosphatebuffered	phosphatebuffered	JJ
cord-272051-arz8r204	239	23	saline	saline	NN
cord-272051-arz8r204	239	24	.	.	.
cord-272051-arz8r204	240	1	Portions	portion	NNS
cord-272051-arz8r204	240	2	of	of	IN
cord-272051-arz8r204	240	3	the	the	DT
cord-272051-arz8r204	240	4	solution	solution	NN
cord-272051-arz8r204	240	5	were	be	VBD
cord-272051-arz8r204	240	6	stored	store	VBN
cord-272051-arz8r204	240	7	as	as	IN
cord-272051-arz8r204	240	8	aliquots	aliquot	NNS
cord-272051-arz8r204	240	9	at	at	IN
cord-272051-arz8r204	240	10	−20	−20	NNP
cord-272051-arz8r204	240	11	°	°	NN
cord-272051-arz8r204	240	12	C	C	NNP
cord-272051-arz8r204	240	13	.	.	.
cord-272051-arz8r204	241	1	Influenza	influenza	NN
cord-272051-arz8r204	241	2	preparations	preparation	NNS
cord-272051-arz8r204	241	3	were	be	VBD
cord-272051-arz8r204	241	4	titrated	titrate	VBN
cord-272051-arz8r204	241	5	by	by	IN
cord-272051-arz8r204	241	6	standard	standard	JJ
cord-272051-arz8r204	241	7	plaque	plaque	NN
cord-272051-arz8r204	241	8	assay	assay	NN
cord-272051-arz8r204	241	9	on	on	IN
cord-272051-arz8r204	241	10	MDCK	MDCK	NNP
cord-272051-arz8r204	241	11	cells	cell	NNS
cord-272051-arz8r204	241	12	.	.	.
cord-272051-arz8r204	242	1	Virus	virus	NN
cord-272051-arz8r204	242	2	titers	titer	NNS
cord-272051-arz8r204	242	3	for	for	IN
cord-272051-arz8r204	242	4	these	these	DT
cord-272051-arz8r204	242	5	stocks	stock	NNS
cord-272051-arz8r204	242	6	ranged	range	VBD
cord-272051-arz8r204	242	7	from	from	IN
cord-272051-arz8r204	242	8	1	1	CD
cord-272051-arz8r204	242	9	to	to	IN
cord-272051-arz8r204	242	10	8	8	CD
cord-272051-arz8r204	242	11	×	×	NN
cord-272051-arz8r204	243	1	10	10	CD
cord-272051-arz8r204	243	2	7	7	CD
cord-272051-arz8r204	243	3	PFU	pfu	NN
cord-272051-arz8r204	243	4	/	/	SYM
cord-272051-arz8r204	243	5	ml	ml	NN
cord-272051-arz8r204	243	6	.	.	.
cord-272051-arz8r204	244	1	Preparations	preparation	NNS
cord-272051-arz8r204	244	2	of	of	IN
cord-272051-arz8r204	244	3	the	the	DT
cord-272051-arz8r204	244	4	Hertz	Hertz	NNP
cord-272051-arz8r204	244	5	strain	strain	NN
cord-272051-arz8r204	244	6	of	of	IN
cord-272051-arz8r204	244	7	NDV	NDV	NNP
cord-272051-arz8r204	244	8	were	be	VBD
cord-272051-arz8r204	244	9	recovered	recover	VBN
cord-272051-arz8r204	244	10	after	after	IN
cord-272051-arz8r204	244	11	48	48	CD
cord-272051-arz8r204	244	12	h	h	NN
cord-272051-arz8r204	244	13	of	of	IN
cord-272051-arz8r204	244	14	incubation	incubation	NN
cord-272051-arz8r204	244	15	in	in	IN
cord-272051-arz8r204	244	16	9	9	CD
cord-272051-arz8r204	244	17	-	-	HYPH
cord-272051-arz8r204	244	18	11-day	11-day	CD
cord-272051-arz8r204	244	19	-	-	HYPH
cord-272051-arz8r204	244	20	old	old	JJ
cord-272051-arz8r204	244	21	embryonated	embryonate	VBN
cord-272051-arz8r204	244	22	chicken	chicken	NN
cord-272051-arz8r204	244	23	eggs	egg	NNS
cord-272051-arz8r204	244	24	inoculated	inoculate	VBN
cord-272051-arz8r204	244	25	in	in	IN
cord-272051-arz8r204	244	26	the	the	DT
cord-272051-arz8r204	244	27	allantoic	allantoic	NNP
cord-272051-arz8r204	244	28	cavity	cavity	NN
cord-272051-arz8r204	244	29	.	.	.
cord-272051-arz8r204	245	1	After	after	IN
cord-272051-arz8r204	245	2	harvesting	harvest	VBG
cord-272051-arz8r204	245	3	,	,	,
cord-272051-arz8r204	245	4	the	the	DT
cord-272051-arz8r204	245	5	allantoic	allantoic	NNP
cord-272051-arz8r204	245	6	fluid	fluid	NN
cord-272051-arz8r204	245	7	was	be	VBD
cord-272051-arz8r204	245	8	clarified	clarify	VBN
cord-272051-arz8r204	245	9	by	by	IN
cord-272051-arz8r204	245	10	centrifugation	centrifugation	NN
cord-272051-arz8r204	245	11	at	at	IN
cord-272051-arz8r204	245	12	10,000×g	10,000×g	CD
cord-272051-arz8r204	245	13	,	,	,
cord-272051-arz8r204	245	14	and	and	CC
cord-272051-arz8r204	245	15	titrated	titrate	VBN
cord-272051-arz8r204	245	16	as	as	IN
cord-272051-arz8r204	245	17	infectious	infectious	JJ
cord-272051-arz8r204	245	18	units	unit	NNS
cord-272051-arz8r204	245	19	/	/	SYM
cord-272051-arz8r204	245	20	ml	ml	XX
cord-272051-arz8r204	245	21	through	through	IN
cord-272051-arz8r204	245	22	the	the	DT
cord-272051-arz8r204	245	23	end	end	NN
cord-272051-arz8r204	245	24	-	-	HYPH
cord-272051-arz8r204	245	25	dilution	dilution	NN
cord-272051-arz8r204	245	26	method	method	NN
cord-272051-arz8r204	245	27	by	by	IN
cord-272051-arz8r204	245	28	assessing	assess	VBG
cord-272051-arz8r204	245	29	the	the	DT
cord-272051-arz8r204	245	30	cytopathic	cytopathic	JJ
cord-272051-arz8r204	245	31	effect	effect	NN
cord-272051-arz8r204	245	32	on	on	IN
cord-272051-arz8r204	245	33	MDCK	MDCK	NNP
cord-272051-arz8r204	245	34	cells	cell	NNS
cord-272051-arz8r204	245	35	48	48	CD
cord-272051-arz8r204	245	36	h	h	NN
cord-272051-arz8r204	245	37	post	post	NN
cord-272051-arz8r204	245	38	infection	infection	NN
cord-272051-arz8r204	245	39	.	.	.
cord-272051-arz8r204	246	1	The	the	DT
cord-272051-arz8r204	246	2	titer	titer	NN
cord-272051-arz8r204	246	3	of	of	IN
cord-272051-arz8r204	246	4	the	the	DT
cord-272051-arz8r204	246	5	viral	viral	JJ
cord-272051-arz8r204	246	6	stock	stock	NN
cord-272051-arz8r204	246	7	used	use	VBN
cord-272051-arz8r204	246	8	was	be	VBD
cord-272051-arz8r204	246	9	2.1	2.1	CD
cord-272051-arz8r204	246	10	×	×	NN
cord-272051-arz8r204	246	11	10	10	CD
cord-272051-arz8r204	246	12	7	7	CD
cord-272051-arz8r204	246	13	infectious	infectious	JJ
cord-272051-arz8r204	246	14	units	unit	NNS
cord-272051-arz8r204	246	15	/	/	SYM
cord-272051-arz8r204	246	16	ml	ml	NN
cord-272051-arz8r204	246	17	.	.	.
cord-272051-arz8r204	247	1	CEM	CEM	NNP
cord-272051-arz8r204	247	2	GFP	GFP	NNP
cord-272051-arz8r204	247	3	cells	cell	NNS
cord-272051-arz8r204	247	4	were	be	VBD
cord-272051-arz8r204	247	5	grown	grow	VBN
cord-272051-arz8r204	247	6	in	in	IN
cord-272051-arz8r204	247	7	Roswell	Roswell	NNP
cord-272051-arz8r204	247	8	Park	Park	NNP
cord-272051-arz8r204	247	9	Memorial	Memorial	NNP
cord-272051-arz8r204	247	10	Institute	Institute	NNP
cord-272051-arz8r204	247	11	(	(	-LRB-
cord-272051-arz8r204	247	12	RPMI	RPMI	NNP
cord-272051-arz8r204	247	13	)	)	-RRB-
cord-272051-arz8r204	247	14	medium	medium	NN
cord-272051-arz8r204	247	15	supplemented	supplement	VBN
cord-272051-arz8r204	247	16	with	with	IN
cord-272051-arz8r204	247	17	10	10	CD
cord-272051-arz8r204	247	18	%	%	NN
cord-272051-arz8r204	247	19	heat	heat	NN
cord-272051-arz8r204	247	20	-	-	HYPH
cord-272051-arz8r204	247	21	inactivated	inactivate	VBN
cord-272051-arz8r204	247	22	fetal	fetal	JJ
cord-272051-arz8r204	247	23	calf	calf	NN
cord-272051-arz8r204	247	24	serum	serum	NN
cord-272051-arz8r204	247	25	(	(	-LRB-
cord-272051-arz8r204	247	26	FCS	FCS	NNP
cord-272051-arz8r204	247	27	)	)	-RRB-
cord-272051-arz8r204	247	28	.	.	.
cord-272051-arz8r204	248	1	HeLa	HeLa	NNP
cord-272051-arz8r204	248	2	,	,	,
cord-272051-arz8r204	248	3	MDCK	MDCK	NNP
cord-272051-arz8r204	248	4	,	,	,
cord-272051-arz8r204	248	5	293	293	CD
cord-272051-arz8r204	248	6	T	t	NN
cord-272051-arz8r204	248	7	and	and	CC
cord-272051-arz8r204	248	8	293	293	CD
cord-272051-arz8r204	248	9	/	/	SYM
cord-272051-arz8r204	248	10	GPR	GPR	NNP
cord-272051-arz8r204	248	11	inducible	inducible	JJ
cord-272051-arz8r204	248	12	HIV-1	HIV-1	NNP
cord-272051-arz8r204	248	13	packaging	packaging	NN
cord-272051-arz8r204	248	14	cells	cell	NNS
cord-272051-arz8r204	248	15	(	(	-LRB-
cord-272051-arz8r204	248	16	Sparacio	Sparacio	NNP
cord-272051-arz8r204	248	17	et	et	FW
cord-272051-arz8r204	248	18	al	al	NNP
cord-272051-arz8r204	248	19	.	.	NNP
cord-272051-arz8r204	248	20	,	,	,
cord-272051-arz8r204	248	21	2001	2001	CD
cord-272051-arz8r204	248	22	)	)	-RRB-
cord-272051-arz8r204	248	23	were	be	VBD
cord-272051-arz8r204	248	24	grown	grow	VBN
cord-272051-arz8r204	248	25	in	in	IN
cord-272051-arz8r204	248	26	Dulbecco	Dulbecco	NNP
cord-272051-arz8r204	248	27	's	's	POS
cord-272051-arz8r204	248	28	modified	modify	VBN
cord-272051-arz8r204	248	29	Eagle	Eagle	NNP
cord-272051-arz8r204	248	30	's	's	POS
cord-272051-arz8r204	248	31	medium	medium	NN
cord-272051-arz8r204	248	32	plus	plus	CC
cord-272051-arz8r204	248	33	10	10	CD
cord-272051-arz8r204	248	34	%	%	NN
cord-272051-arz8r204	248	35	FCS	FCS	NNP
cord-272051-arz8r204	248	36	.	.	.
cord-272051-arz8r204	249	1	Infections	infection	NNS
cord-272051-arz8r204	249	2	of	of	IN
cord-272051-arz8r204	249	3	CEM	CEM	NNP
cord-272051-arz8r204	249	4	GFP	GFP	NNP
cord-272051-arz8r204	249	5	cells	cell	NNS
cord-272051-arz8r204	249	6	with	with	IN
cord-272051-arz8r204	249	7	HIV-1	HIV-1	NNP
cord-272051-arz8r204	249	8	or	or	CC
cord-272051-arz8r204	249	9	pseudotyped	pseudotyped	NNP
cord-272051-arz8r204	249	10	derivatives	derivative	NNS
cord-272051-arz8r204	249	11	were	be	VBD
cord-272051-arz8r204	249	12	carried	carry	VBN
cord-272051-arz8r204	249	13	out	out	RP
cord-272051-arz8r204	249	14	by	by	IN
cord-272051-arz8r204	249	15	spinoculation	spinoculation	NN
cord-272051-arz8r204	249	16	at	at	IN
cord-272051-arz8r204	249	17	400	400	CD
cord-272051-arz8r204	249	18	×	×	NN
cord-272051-arz8r204	249	19	g	g	NN
cord-272051-arz8r204	249	20	for	for	IN
cord-272051-arz8r204	249	21	30	30	CD
cord-272051-arz8r204	249	22	min	min	NN
cord-272051-arz8r204	249	23	at	at	IN
cord-272051-arz8r204	249	24	room	room	NN
cord-272051-arz8r204	249	25	temperature	temperature	NN
cord-272051-arz8r204	249	26	(	(	-LRB-
cord-272051-arz8r204	249	27	r.t	r.t	NNP
cord-272051-arz8r204	249	28	.	.	.
cord-272051-arz8r204	249	29	)	)	-RRB-
cord-272051-arz8r204	249	30	using	use	VBG
cord-272051-arz8r204	249	31	200	200	CD
cord-272051-arz8r204	249	32	ng	ng	NN
cord-272051-arz8r204	249	33	and	and	CC
cord-272051-arz8r204	249	34	50	50	CD
cord-272051-arz8r204	249	35	ng	ng	NN
cord-272051-arz8r204	249	36	CAp24	CAp24	NNS
cord-272051-arz8r204	249	37	equivalent	equivalent	NN
cord-272051-arz8r204	249	38	of	of	IN
cord-272051-arz8r204	249	39	HIV-1	HIV-1	NNP
cord-272051-arz8r204	249	40	and	and	CC
cord-272051-arz8r204	249	41	(	(	-LRB-
cord-272051-arz8r204	249	42	VSV	VSV	NNP
cord-272051-arz8r204	249	43	-	-	HYPH
cord-272051-arz8r204	249	44	G	G	NNP
cord-272051-arz8r204	249	45	)	)	-RRB-
cord-272051-arz8r204	249	46	HIV-1/10	hiv-1/10	NN
cord-272051-arz8r204	249	47	5	5	CD
cord-272051-arz8r204	249	48	cells	cell	NNS
cord-272051-arz8r204	249	49	,	,	,
cord-272051-arz8r204	249	50	respectively	respectively	RB
cord-272051-arz8r204	249	51	.	.	.
cord-272051-arz8r204	250	1	Then	then	RB
cord-272051-arz8r204	250	2	,	,	,
cord-272051-arz8r204	250	3	virus	virus	NN
cord-272051-arz8r204	250	4	adsorption	adsorption	NN
cord-272051-arz8r204	250	5	was	be	VBD
cord-272051-arz8r204	250	6	prolonged	prolong	VBN
cord-272051-arz8r204	250	7	for	for	IN
cord-272051-arz8r204	250	8	additional	additional	JJ
cord-272051-arz8r204	250	9	2	2	CD
cord-272051-arz8r204	250	10	h	h	NN
cord-272051-arz8r204	250	11	at	at	IN
cord-272051-arz8r204	250	12	37	37	CD
cord-272051-arz8r204	250	13	°	°	NN
cord-272051-arz8r204	250	14	C	c	NN
cord-272051-arz8r204	250	15	and	and	CC
cord-272051-arz8r204	250	16	,	,	,
cord-272051-arz8r204	250	17	finally	finally	RB
cord-272051-arz8r204	250	18	,	,	,
cord-272051-arz8r204	250	19	cells	cell	NNS
cord-272051-arz8r204	250	20	were	be	VBD
cord-272051-arz8r204	250	21	washed	wash	VBN
cord-272051-arz8r204	250	22	and	and	CC
cord-272051-arz8r204	250	23	refed	refe	VBN
cord-272051-arz8r204	250	24	with	with	IN
cord-272051-arz8r204	250	25	the	the	DT
cord-272051-arz8r204	250	26	complete	complete	JJ
cord-272051-arz8r204	250	27	medium	medium	NN
cord-272051-arz8r204	250	28	.	.	.
cord-272051-arz8r204	251	1	HeLa	HeLa	NNP
cord-272051-arz8r204	251	2	cells	cell	NNS
cord-272051-arz8r204	251	3	were	be	VBD
cord-272051-arz8r204	251	4	infected	infect	VBN
cord-272051-arz8r204	251	5	with	with	IN
cord-272051-arz8r204	251	6	VSV	VSV	NNP
cord-272051-arz8r204	251	7	by	by	IN
cord-272051-arz8r204	251	8	adsorbing	adsorb	VBG
cord-272051-arz8r204	251	9	the	the	DT
cord-272051-arz8r204	251	10	viral	viral	JJ
cord-272051-arz8r204	251	11	inoculum	inoculum	NN
cord-272051-arz8r204	251	12	for	for	IN
cord-272051-arz8r204	251	13	1	1	CD
cord-272051-arz8r204	251	14	h	h	NN
cord-272051-arz8r204	251	15	at	at	IN
cord-272051-arz8r204	251	16	37	37	CD
cord-272051-arz8r204	251	17	°	°	NN
cord-272051-arz8r204	251	18	C	c	NN
cord-272051-arz8r204	251	19	in	in	IN
cord-272051-arz8r204	251	20	a	a	DT
cord-272051-arz8r204	251	21	small	small	JJ
cord-272051-arz8r204	251	22	volume	volume	NN
cord-272051-arz8r204	251	23	(	(	-LRB-
cord-272051-arz8r204	251	24	e.g.	e.g.	RB
cord-272051-arz8r204	251	25	,	,	,
cord-272051-arz8r204	251	26	0.1	0.1	CD
cord-272051-arz8r204	251	27	ml	ml	NNS
cord-272051-arz8r204	251	28	of	of	IN
cord-272051-arz8r204	251	29	serum	serum	NN
cord-272051-arz8r204	251	30	free	free	JJ
cord-272051-arz8r204	251	31	medium	medium	NN
cord-272051-arz8r204	251	32	for	for	IN
cord-272051-arz8r204	251	33	2	2	CD
cord-272051-arz8r204	251	34	×	×	CD
cord-272051-arz8r204	251	35	10	10	CD
cord-272051-arz8r204	251	36	5	5	CD
cord-272051-arz8r204	251	37	cells	cell	NNS
cord-272051-arz8r204	251	38	in	in	IN
cord-272051-arz8r204	251	39	12	12	CD
cord-272051-arz8r204	251	40	well	well	NN
cord-272051-arz8r204	251	41	plates	plate	NNS
cord-272051-arz8r204	251	42	)	)	-RRB-
cord-272051-arz8r204	251	43	.	.	.
cord-272051-arz8r204	252	1	Thereafter	thereafter	RB
cord-272051-arz8r204	252	2	,	,	,
cord-272051-arz8r204	252	3	the	the	DT
cord-272051-arz8r204	252	4	cells	cell	NNS
cord-272051-arz8r204	252	5	were	be	VBD
cord-272051-arz8r204	252	6	extensively	extensively	RB
cord-272051-arz8r204	252	7	washed	wash	VBN
cord-272051-arz8r204	252	8	,	,	,
cord-272051-arz8r204	252	9	and	and	CC
cord-272051-arz8r204	252	10	refed	refe	VBN
cord-272051-arz8r204	252	11	with	with	IN
cord-272051-arz8r204	252	12	appropriate	appropriate	JJ
cord-272051-arz8r204	252	13	complete	complete	JJ
cord-272051-arz8r204	252	14	medium	medium	NN
cord-272051-arz8r204	252	15	.	.	.
cord-272051-arz8r204	253	1	MDCK	MDCK	NNP
cord-272051-arz8r204	253	2	cells	cell	NNS
cord-272051-arz8r204	253	3	were	be	VBD
cord-272051-arz8r204	253	4	used	use	VBN
cord-272051-arz8r204	253	5	as	as	IN
cord-272051-arz8r204	253	6	targets	target	NNS
cord-272051-arz8r204	253	7	of	of	IN
cord-272051-arz8r204	253	8	PR8	PR8	NNP
cord-272051-arz8r204	253	9	influenza	influenza	NN
cord-272051-arz8r204	253	10	virus	virus	NN
cord-272051-arz8r204	253	11	.	.	.
cord-272051-arz8r204	254	1	The	the	DT
cord-272051-arz8r204	254	2	challenges	challenge	NNS
cord-272051-arz8r204	254	3	were	be	VBD
cord-272051-arz8r204	254	4	carried	carry	VBN
cord-272051-arz8r204	254	5	out	out	RP
cord-272051-arz8r204	254	6	as	as	IN
cord-272051-arz8r204	254	7	for	for	IN
cord-272051-arz8r204	254	8	VSV	VSV	NNP
cord-272051-arz8r204	254	9	infection	infection	NN
cord-272051-arz8r204	254	10	,	,	,
cord-272051-arz8r204	254	11	except	except	IN
cord-272051-arz8r204	254	12	that	that	DT
cord-272051-arz8r204	254	13	after	after	IN
cord-272051-arz8r204	254	14	virus	virus	NN
cord-272051-arz8r204	254	15	adsorption	adsorption	NN
cord-272051-arz8r204	254	16	,	,	,
cord-272051-arz8r204	254	17	cells	cell	NNS
cord-272051-arz8r204	254	18	were	be	VBD
cord-272051-arz8r204	254	19	refed	refe	VBN
cord-272051-arz8r204	254	20	with	with	IN
cord-272051-arz8r204	254	21	medium	medium	NN
cord-272051-arz8r204	254	22	without	without	IN
cord-272051-arz8r204	254	23	serum	serum	NN
cord-272051-arz8r204	254	24	in	in	IN
cord-272051-arz8r204	254	25	the	the	DT
cord-272051-arz8r204	254	26	presence	presence	NN
cord-272051-arz8r204	254	27	of	of	IN
cord-272051-arz8r204	254	28	1	1	CD
cord-272051-arz8r204	254	29	μg	μg	NNP
cord-272051-arz8r204	254	30	/	/	SYM
cord-272051-arz8r204	254	31	ml	ml	NNS
cord-272051-arz8r204	254	32	of	of	IN
cord-272051-arz8r204	254	33	TPCK	TPCK	NNP
cord-272051-arz8r204	254	34	-	-	HYPH
cord-272051-arz8r204	254	35	treated	treat	VBN
cord-272051-arz8r204	254	36	trypsin	trypsin	NN
cord-272051-arz8r204	254	37	(	(	-LRB-
cord-272051-arz8r204	254	38	Worthington	Worthington	NNP
cord-272051-arz8r204	254	39	Biochemical	Biochemical	NNP
cord-272051-arz8r204	254	40	Corporation	Corporation	NNP
cord-272051-arz8r204	254	41	)	)	-RRB-
cord-272051-arz8r204	254	42	.	.	.
cord-272051-arz8r204	255	1	HeLa	HeLa	NNP
cord-272051-arz8r204	255	2	and	and	CC
cord-272051-arz8r204	255	3	MDCK	MDCK	NNP
cord-272051-arz8r204	255	4	cells	cell	NNS
cord-272051-arz8r204	255	5	served	serve	VBD
cord-272051-arz8r204	255	6	to	to	TO
cord-272051-arz8r204	255	7	titrate	titrate	VB
cord-272051-arz8r204	255	8	infectious	infectious	JJ
cord-272051-arz8r204	255	9	VSV	VSV	NNP
cord-272051-arz8r204	255	10	and	and	CC
cord-272051-arz8r204	255	11	influenza	influenza	NN
cord-272051-arz8r204	255	12	virus	virus	NN
cord-272051-arz8r204	255	13	in	in	IN
cord-272051-arz8r204	255	14	supernatants	supernatant	NNS
cord-272051-arz8r204	255	15	harvested	harvest	VBN
cord-272051-arz8r204	255	16	after	after	IN
cord-272051-arz8r204	255	17	challenge	challenge	NN
cord-272051-arz8r204	255	18	experiments	experiment	NNS
cord-272051-arz8r204	255	19	.	.	.
cord-272051-arz8r204	256	1	The	the	DT
cord-272051-arz8r204	256	2	titrations	titration	NNS
cord-272051-arz8r204	256	3	were	be	VBD
cord-272051-arz8r204	256	4	carried	carry	VBN
cord-272051-arz8r204	256	5	out	out	RP
cord-272051-arz8r204	256	6	by	by	IN
cord-272051-arz8r204	256	7	the	the	DT
cord-272051-arz8r204	256	8	end	end	NN
cord-272051-arz8r204	256	9	-	-	HYPH
cord-272051-arz8r204	256	10	dilution	dilution	NN
cord-272051-arz8r204	256	11	method	method	NN
cord-272051-arz8r204	256	12	with	with	IN
cord-272051-arz8r204	256	13	triplicate	triplicate	JJ
cord-272051-arz8r204	256	14	conditions	condition	NNS
cord-272051-arz8r204	256	15	by	by	IN
cord-272051-arz8r204	256	16	challenging	challenge	VBG
cord-272051-arz8r204	256	17	the	the	DT
cord-272051-arz8r204	256	18	cells	cell	NNS
cord-272051-arz8r204	256	19	with	with	IN
cord-272051-arz8r204	256	20	3-fold	3-fold	CD
cord-272051-arz8r204	256	21	scaled	scaled	JJ
cord-272051-arz8r204	256	22	supernatant	supernatant	JJ
cord-272051-arz8r204	256	23	dilutions	dilution	NNS
cord-272051-arz8r204	256	24	(	(	-LRB-
cord-272051-arz8r204	256	25	in	in	IN
cord-272051-arz8r204	256	26	the	the	DT
cord-272051-arz8r204	256	27	presence	presence	NN
cord-272051-arz8r204	256	28	of	of	IN
cord-272051-arz8r204	256	29	1	1	CD
cord-272051-arz8r204	256	30	μg	μg	NNP
cord-272051-arz8r204	256	31	/	/	SYM
cord-272051-arz8r204	256	32	ml	ml	NNP
cord-272051-arz8r204	256	33	TPCK	TPCK	NNP
cord-272051-arz8r204	256	34	-	-	HYPH
cord-272051-arz8r204	256	35	trypsin	trypsin	NN
cord-272051-arz8r204	256	36	for	for	IN
cord-272051-arz8r204	256	37	influenza	influenza	NN
cord-272051-arz8r204	256	38	virus	virus	NN
cord-272051-arz8r204	256	39	titrations	titration	NNS
cord-272051-arz8r204	256	40	)	)	-RRB-
cord-272051-arz8r204	256	41	,	,	,
cord-272051-arz8r204	256	42	and	and	CC
cord-272051-arz8r204	256	43	by	by	IN
cord-272051-arz8r204	256	44	evaluating	evaluate	VBG
cord-272051-arz8r204	256	45	the	the	DT
cord-272051-arz8r204	256	46	cytopathic	cytopathic	JJ
cord-272051-arz8r204	256	47	effect	effect	NN
cord-272051-arz8r204	256	48	after	after	IN
cord-272051-arz8r204	256	49	36	36	CD
cord-272051-arz8r204	256	50	h	h	NN
cord-272051-arz8r204	256	51	(	(	-LRB-
cord-272051-arz8r204	256	52	for	for	IN
cord-272051-arz8r204	256	53	VSV	VSV	NNP
cord-272051-arz8r204	256	54	)	)	-RRB-
cord-272051-arz8r204	256	55	and	and	CC
cord-272051-arz8r204	256	56	72	72	CD
cord-272051-arz8r204	256	57	h	h	NN
cord-272051-arz8r204	256	58	(	(	-LRB-
cord-272051-arz8r204	256	59	for	for	IN
cord-272051-arz8r204	256	60	influenza	influenza	NN
cord-272051-arz8r204	256	61	virus	virus	NN
cord-272051-arz8r204	256	62	)	)	-RRB-
cord-272051-arz8r204	256	63	.	.	.
cord-272051-arz8r204	257	1	Concentrated	concentrated	JJ
cord-272051-arz8r204	257	2	virus	virus	NN
cord-272051-arz8r204	257	3	preparations	preparation	NNS
cord-272051-arz8r204	257	4	previously	previously	RB
cord-272051-arz8r204	257	5	titrated	titrate	VBN
cord-272051-arz8r204	257	6	by	by	IN
cord-272051-arz8r204	257	7	the	the	DT
cord-272051-arz8r204	257	8	plaque	plaque	NN
cord-272051-arz8r204	257	9	assay	assay	NN
cord-272051-arz8r204	257	10	were	be	VBD
cord-272051-arz8r204	257	11	used	use	VBN
cord-272051-arz8r204	257	12	as	as	IN
cord-272051-arz8r204	257	13	standards	standard	NNS
cord-272051-arz8r204	257	14	.	.	.
cord-272051-arz8r204	258	1	For	for	IN
cord-272051-arz8r204	258	2	NDV	ndv	JJ
cord-272051-arz8r204	258	3	infections	infection	NNS
cord-272051-arz8r204	258	4	,	,	,
cord-272051-arz8r204	258	5	MDCK	MDCK	NNP
cord-272051-arz8r204	258	6	cells	cell	NNS
cord-272051-arz8r204	258	7	were	be	VBD
cord-272051-arz8r204	258	8	challenged	challenge	VBN
cord-272051-arz8r204	258	9	with	with	IN
cord-272051-arz8r204	258	10	2-fold	2-fold	DT
cord-272051-arz8r204	258	11	decreasing	decrease	VBG
cord-272051-arz8r204	258	12	viral	viral	JJ
cord-272051-arz8r204	258	13	dilutions	dilution	NNS
cord-272051-arz8r204	258	14	starting	start	VBG
cord-272051-arz8r204	258	15	to	to	IN
cord-272051-arz8r204	258	16	m.o.i	m.o.i	NNP
cord-272051-arz8r204	258	17	.	.	NNP
cord-272051-arz8r204	258	18	1	1	CD
cord-272051-arz8r204	258	19	,	,	,
cord-272051-arz8r204	258	20	and	and	CC
cord-272051-arz8r204	258	21	the	the	DT
cord-272051-arz8r204	258	22	cythopatic	cythopatic	JJ
cord-272051-arz8r204	258	23	effect	effect	NN
cord-272051-arz8r204	258	24	was	be	VBD
cord-272051-arz8r204	258	25	assessed	assess	VBN
cord-272051-arz8r204	258	26	48	48	CD
cord-272051-arz8r204	258	27	h	h	NN
cord-272051-arz8r204	258	28	later	later	RB
cord-272051-arz8r204	258	29	.	.	.
cord-272051-arz8r204	259	1	T-20	T-20	NNP
cord-272051-arz8r204	259	2	,	,	,
cord-272051-arz8r204	259	3	ritonavir	ritonavir	NNP
cord-272051-arz8r204	259	4	,	,	,
cord-272051-arz8r204	259	5	indinavir	indinavir	NNP
cord-272051-arz8r204	259	6	,	,	,
cord-272051-arz8r204	259	7	saquinavir	saquinavir	NNP
cord-272051-arz8r204	259	8	,	,	,
cord-272051-arz8r204	259	9	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	259	10	,	,	,
cord-272051-arz8r204	259	11	amprenavir	amprenavir	NNP
cord-272051-arz8r204	259	12	and	and	CC
cord-272051-arz8r204	259	13	atazanavir	atazanavir	NNS
cord-272051-arz8r204	259	14	were	be	VBD
cord-272051-arz8r204	259	15	obtained	obtain	VBN
cord-272051-arz8r204	259	16	from	from	IN
cord-272051-arz8r204	259	17	the	the	DT
cord-272051-arz8r204	259	18	NIH	NIH	NNP
cord-272051-arz8r204	259	19	AIDS	AIDS	NNP
cord-272051-arz8r204	259	20	Research	Research	NNP
cord-272051-arz8r204	259	21	and	and	CC
cord-272051-arz8r204	259	22	Reference	Reference	NNP
cord-272051-arz8r204	259	23	Reagent	Reagent	NNP
cord-272051-arz8r204	259	24	Program	Program	NNP
cord-272051-arz8r204	259	25	.	.	.
cord-272051-arz8r204	260	1	Both	both	DT
cord-272051-arz8r204	260	2	control	control	NN
cord-272051-arz8r204	260	3	and	and	CC
cord-272051-arz8r204	260	4	PI	pi	NN
cord-272051-arz8r204	260	5	-	-	HYPH
cord-272051-arz8r204	260	6	treated	treat	VBN
cord-272051-arz8r204	260	7	cells	cell	NNS
cord-272051-arz8r204	260	8	were	be	VBD
cord-272051-arz8r204	260	9	labeled	label	VBN
cord-272051-arz8r204	260	10	with	with	IN
cord-272051-arz8r204	260	11	1	1	CD
cord-272051-arz8r204	260	12	μM	μm	CD
cord-272051-arz8r204	260	13	CFSE	CFSE	NNP
cord-272051-arz8r204	260	14	(	(	-LRB-
cord-272051-arz8r204	260	15	Molecular	Molecular	NNP
cord-272051-arz8r204	260	16	Probes	Probes	NNPS
cord-272051-arz8r204	260	17	,	,	,
cord-272051-arz8r204	260	18	Invitrogen	Invitrogen	NNP
cord-272051-arz8r204	260	19	)	)	-RRB-
cord-272051-arz8r204	260	20	following	follow	VBG
cord-272051-arz8r204	260	21	the	the	DT
cord-272051-arz8r204	260	22	manufacturer	manufacturer	NN
cord-272051-arz8r204	260	23	's	's	POS
cord-272051-arz8r204	260	24	recommendations	recommendation	NNS
cord-272051-arz8r204	260	25	.	.	.
cord-272051-arz8r204	261	1	A	a	DT
cord-272051-arz8r204	261	2	cell	cell	NN
cord-272051-arz8r204	261	3	sample	sample	NN
cord-272051-arz8r204	261	4	was	be	VBD
cord-272051-arz8r204	261	5	immediately	immediately	RB
cord-272051-arz8r204	261	6	processed	process	VBN
cord-272051-arz8r204	261	7	to	to	TO
cord-272051-arz8r204	261	8	determine	determine	VB
cord-272051-arz8r204	261	9	the	the	DT
cord-272051-arz8r204	261	10	fluorescence	fluorescence	NN
cord-272051-arz8r204	261	11	levels	level	NNS
cord-272051-arz8r204	261	12	at	at	IN
cord-272051-arz8r204	261	13	the	the	DT
cord-272051-arz8r204	261	14	zero	zero	CD
cord-272051-arz8r204	261	15	time	time	NN
cord-272051-arz8r204	261	16	.	.	.
cord-272051-arz8r204	262	1	Thereafter	thereafter	RB
cord-272051-arz8r204	262	2	,	,	,
cord-272051-arz8r204	262	3	the	the	DT
cord-272051-arz8r204	262	4	remainder	remainder	NN
cord-272051-arz8r204	262	5	cell	cell	NN
cord-272051-arz8r204	262	6	cultures	culture	NNS
cord-272051-arz8r204	262	7	were	be	VBD
cord-272051-arz8r204	262	8	refed	refe	VBN
cord-272051-arz8r204	262	9	with	with	IN
cord-272051-arz8r204	262	10	complete	complete	JJ
cord-272051-arz8r204	262	11	medium	medium	NN
cord-272051-arz8r204	262	12	and	and	CC
cord-272051-arz8r204	262	13	,	,	,
cord-272051-arz8r204	262	14	at	at	IN
cord-272051-arz8r204	262	15	the	the	DT
cord-272051-arz8r204	262	16	time	time	NN
cord-272051-arz8r204	262	17	of	of	IN
cord-272051-arz8r204	262	18	completion	completion	NN
cord-272051-arz8r204	262	19	of	of	IN
cord-272051-arz8r204	262	20	one	one	CD
cord-272051-arz8r204	262	21	cell	cell	NN
cord-272051-arz8r204	262	22	duplication	duplication	NN
cord-272051-arz8r204	262	23	(	(	-LRB-
cord-272051-arz8r204	262	24	on	on	IN
cord-272051-arz8r204	262	25	the	the	DT
cord-272051-arz8r204	262	26	average	average	NN
cord-272051-arz8r204	262	27	,	,	,
cord-272051-arz8r204	262	28	12	12	CD
cord-272051-arz8r204	262	29	h	h	NN
cord-272051-arz8r204	262	30	for	for	IN
cord-272051-arz8r204	262	31	both	both	DT
cord-272051-arz8r204	262	32	HeLa	HeLa	NNP
cord-272051-arz8r204	262	33	and	and	CC
cord-272051-arz8r204	262	34	MDCK	MDCK	NNP
cord-272051-arz8r204	262	35	cells	cell	NNS
cord-272051-arz8r204	262	36	at	at	IN
cord-272051-arz8r204	262	37	their	-PRON-	PRP$
cord-272051-arz8r204	262	38	logarithmic	logarithmic	JJ
cord-272051-arz8r204	262	39	phase	phase	NN
cord-272051-arz8r204	262	40	)	)	-RRB-
cord-272051-arz8r204	262	41	,	,	,
cord-272051-arz8r204	262	42	were	be	VBD
cord-272051-arz8r204	262	43	harvested	harvest	VBN
cord-272051-arz8r204	262	44	,	,	,
cord-272051-arz8r204	262	45	and	and	CC
cord-272051-arz8r204	262	46	the	the	DT
cord-272051-arz8r204	262	47	fluorescence	fluorescence	NN
cord-272051-arz8r204	262	48	measured	measure	VBN
cord-272051-arz8r204	262	49	by	by	IN
cord-272051-arz8r204	262	50	FACS	FACS	NNP
cord-272051-arz8r204	262	51	analysis	analysis	NN
cord-272051-arz8r204	262	52	.	.	.
cord-272051-arz8r204	263	1	Dead	dead	JJ
cord-272051-arz8r204	263	2	cells	cell	NNS
cord-272051-arz8r204	263	3	were	be	VBD
cord-272051-arz8r204	263	4	identified	identify	VBN
cord-272051-arz8r204	263	5	upon	upon	IN
cord-272051-arz8r204	263	6	labeling	label	VBG
cord-272051-arz8r204	263	7	with	with	IN
cord-272051-arz8r204	263	8	5	5	CD
cord-272051-arz8r204	263	9	μg	μg	NNP
cord-272051-arz8r204	263	10	/	/	SYM
cord-272051-arz8r204	263	11	ml	ml	NNP
cord-272051-arz8r204	263	12	of	of	IN
cord-272051-arz8r204	263	13	propidium	propidium	JJ
cord-272051-arz8r204	263	14	iodide	iodide	NN
cord-272051-arz8r204	263	15	(	(	-LRB-
cord-272051-arz8r204	263	16	Sigma	Sigma	NNP
cord-272051-arz8r204	263	17	-	-	HYPH
cord-272051-arz8r204	263	18	Aldrich	Aldrich	NNP
cord-272051-arz8r204	263	19	)	)	-RRB-
cord-272051-arz8r204	263	20	.	.	.
cord-272051-arz8r204	264	1	Preparation	preparation	NN
cord-272051-arz8r204	264	2	of	of	IN
cord-272051-arz8r204	264	3	fluorescent	fluorescent	JJ
cord-272051-arz8r204	264	4	VLPs	vlp	NNS
cord-272051-arz8r204	264	5	,	,	,
cord-272051-arz8r204	264	6	challenge	challenge	NN
cord-272051-arz8r204	264	7	,	,	,
cord-272051-arz8r204	264	8	and	and	CC
cord-272051-arz8r204	264	9	detection	detection	NN
cord-272051-arz8r204	264	10	assays	assay	NNS
cord-272051-arz8r204	264	11	Fluorescent	Fluorescent	NNP
cord-272051-arz8r204	264	12	VLPs	vlp	NNS
cord-272051-arz8r204	264	13	were	be	VBD
cord-272051-arz8r204	264	14	obtained	obtain	VBN
cord-272051-arz8r204	264	15	as	as	IN
cord-272051-arz8r204	264	16	previously	previously	RB
cord-272051-arz8r204	264	17	described	describe	VBN
cord-272051-arz8r204	265	1	(	(	-LRB-
cord-272051-arz8r204	265	2	Muratori	Muratori	NNP
cord-272051-arz8r204	265	3	et	et	NNP
cord-272051-arz8r204	265	4	al	al	NNP
cord-272051-arz8r204	265	5	.	.	NNP
cord-272051-arz8r204	265	6	,	,	,
cord-272051-arz8r204	265	7	2009	2009	CD
cord-272051-arz8r204	265	8	)	)	-RRB-
cord-272051-arz8r204	265	9	.	.	.
cord-272051-arz8r204	266	1	Briefly	briefly	RB
cord-272051-arz8r204	266	2	,	,	,
cord-272051-arz8r204	266	3	293	293	CD
cord-272051-arz8r204	266	4	/	/	SYM
cord-272051-arz8r204	266	5	GPR	GPR	NNP
cord-272051-arz8r204	266	6	HIV-1	HIV-1	NNP
cord-272051-arz8r204	266	7	packaging	packaging	NN
cord-272051-arz8r204	266	8	cells	cell	NNS
cord-272051-arz8r204	266	9	were	be	VBD
cord-272051-arz8r204	266	10	cotransfected	cotransfecte	VBN
cord-272051-arz8r204	266	11	with	with	IN
cord-272051-arz8r204	266	12	vectors	vector	NNS
cord-272051-arz8r204	266	13	expressing	express	VBG
cord-272051-arz8r204	266	14	the	the	DT
cord-272051-arz8r204	266	15	green	green	JJ
cord-272051-arz8r204	266	16	-	-	HYPH
cord-272051-arz8r204	266	17	fluorescent	fluorescent	NN
cord-272051-arz8r204	266	18	protein	protein	NN
cord-272051-arz8r204	266	19	(	(	-LRB-
cord-272051-arz8r204	266	20	GFP	GFP	NNP
cord-272051-arz8r204	266	21	)	)	-RRB-
cord-272051-arz8r204	266	22	fused	fuse	VBD
cord-272051-arz8r204	266	23	at	at	IN
cord-272051-arz8r204	266	24	its	-PRON-	PRP$
cord-272051-arz8r204	266	25	N	n	CD
cord-272051-arz8r204	266	26	-	-	HYPH
cord-272051-arz8r204	266	27	terminus	terminus	NN
cord-272051-arz8r204	266	28	with	with	IN
cord-272051-arz8r204	266	29	a	a	DT
cord-272051-arz8r204	266	30	G	g	NN
cord-272051-arz8r204	266	31	3	3	CD
cord-272051-arz8r204	266	32	C	C	NNP
cord-272051-arz8r204	266	33	HIV-1	HIV-1	NNP
cord-272051-arz8r204	266	34	Nef	Nef	NNP
cord-272051-arz8r204	266	35	mutant	mutant	NN
cord-272051-arz8r204	266	36	,	,	,
cord-272051-arz8r204	266	37	together	together	RB
cord-272051-arz8r204	266	38	with	with	IN
cord-272051-arz8r204	266	39	a	a	DT
cord-272051-arz8r204	266	40	vector	vector	NN
cord-272051-arz8r204	266	41	expressing	express	VBG
cord-272051-arz8r204	266	42	wt	wt	NN
cord-272051-arz8r204	266	43	or	or	CC
cord-272051-arz8r204	266	44	fusion	fusion	NN
cord-272051-arz8r204	266	45	-	-	HYPH
cord-272051-arz8r204	266	46	defective	defective	JJ
cord-272051-arz8r204	266	47	(	(	-LRB-
cord-272051-arz8r204	266	48	fd	fd	NNP
cord-272051-arz8r204	266	49	)	)	-RRB-
cord-272051-arz8r204	266	50	VSV	VSV	NNP
cord-272051-arz8r204	266	51	-	-	HYPH
cord-272051-arz8r204	266	52	G	G	NNP
cord-272051-arz8r204	266	53	(	(	-LRB-
cord-272051-arz8r204	266	54	Fredericksen	Fredericksen	NNP
cord-272051-arz8r204	266	55	and	and	CC
cord-272051-arz8r204	266	56	Whitt	Whitt	NNP
cord-272051-arz8r204	266	57	,	,	,
cord-272051-arz8r204	266	58	1995	1995	CD
cord-272051-arz8r204	266	59	)	)	-RRB-
cord-272051-arz8r204	266	60	.	.	.
cord-272051-arz8r204	267	1	Supernatants	supernatant	NNS
cord-272051-arz8r204	267	2	were	be	VBD
cord-272051-arz8r204	267	3	harvested	harvest	VBN
cord-272051-arz8r204	267	4	2	2	CD
cord-272051-arz8r204	267	5	days	day	NNS
cord-272051-arz8r204	267	6	later	later	RB
cord-272051-arz8r204	267	7	,	,	,
cord-272051-arz8r204	267	8	concentrated	concentrate	VBN
cord-272051-arz8r204	267	9	by	by	IN
cord-272051-arz8r204	267	10	ultra	ultra	JJ
cord-272051-arz8r204	267	11	-	-	JJ
cord-272051-arz8r204	267	12	centrifugation	centrifugation	NN
cord-272051-arz8r204	267	13	on	on	IN
cord-272051-arz8r204	267	14	20	20	CD
cord-272051-arz8r204	267	15	%	%	NN
cord-272051-arz8r204	267	16	sucrose	sucrose	NN
cord-272051-arz8r204	267	17	cushion	cushion	NN
cord-272051-arz8r204	267	18	,	,	,
cord-272051-arz8r204	267	19	and	and	CC
cord-272051-arz8r204	267	20	titrated	titrate	VBN
cord-272051-arz8r204	267	21	for	for	IN
cord-272051-arz8r204	267	22	the	the	DT
cord-272051-arz8r204	267	23	HIV-1	HIV-1	NNP
cord-272051-arz8r204	267	24	CAp24	CAp24	HYPH
cord-272051-arz8r204	267	25	contents	content	NNS
cord-272051-arz8r204	267	26	.	.	.
cord-272051-arz8r204	268	1	For	for	IN
cord-272051-arz8r204	268	2	HeLa	HeLa	NNP
cord-272051-arz8r204	268	3	cell	cell	NN
cord-272051-arz8r204	268	4	challenge	challenge	NN
cord-272051-arz8r204	268	5	,	,	,
cord-272051-arz8r204	268	6	500	500	CD
cord-272051-arz8r204	268	7	ng	ng	NN
cord-272051-arz8r204	268	8	CAp24	CAp24	NNS
cord-272051-arz8r204	268	9	equivalent	equivalent	NN
cord-272051-arz8r204	268	10	of	of	IN
cord-272051-arz8r204	269	1	fluorescent	fluorescent	JJ
cord-272051-arz8r204	269	2	(	(	-LRB-
cord-272051-arz8r204	269	3	VSV	VSV	NNP
cord-272051-arz8r204	269	4	-	-	HYPH
cord-272051-arz8r204	269	5	G	G	NNP
cord-272051-arz8r204	269	6	)	)	-RRB-
cord-272051-arz8r204	269	7	HIV-1	HIV-1	NNP
cord-272051-arz8r204	269	8	VLPs/10	vlps/10	NN
cord-272051-arz8r204	270	1	5	5	CD
cord-272051-arz8r204	270	2	cells	cell	NNS
cord-272051-arz8r204	270	3	were	be	VBD
cord-272051-arz8r204	270	4	adsorbed	adsorb	VBN
cord-272051-arz8r204	270	5	for	for	IN
cord-272051-arz8r204	270	6	1	1	CD
cord-272051-arz8r204	270	7	h	h	NN
cord-272051-arz8r204	270	8	at	at	IN
cord-272051-arz8r204	270	9	4	4	CD
cord-272051-arz8r204	270	10	or	or	CC
cord-272051-arz8r204	270	11	37	37	CD
cord-272051-arz8r204	270	12	°	°	NN
cord-272051-arz8r204	270	13	C	c	NN
cord-272051-arz8r204	270	14	in	in	IN
cord-272051-arz8r204	270	15	a	a	DT
cord-272051-arz8r204	270	16	volume	volume	NN
cord-272051-arz8r204	270	17	of	of	IN
cord-272051-arz8r204	270	18	0.1	0.1	CD
cord-272051-arz8r204	270	19	ml	ml	NNS
cord-272051-arz8r204	270	20	in	in	IN
cord-272051-arz8r204	270	21	48	48	CD
cord-272051-arz8r204	270	22	well	well	JJ
cord-272051-arz8r204	270	23	plates	plate	NNS
cord-272051-arz8r204	270	24	.	.	.
cord-272051-arz8r204	271	1	Thereafter	thereafter	RB
cord-272051-arz8r204	271	2	,	,	,
cord-272051-arz8r204	271	3	0.1	0.1	CD
cord-272051-arz8r204	271	4	ml	ml	NNS
cord-272051-arz8r204	271	5	of	of	IN
cord-272051-arz8r204	271	6	complete	complete	JJ
cord-272051-arz8r204	271	7	medium	medium	NN
cord-272051-arz8r204	271	8	was	be	VBD
cord-272051-arz8r204	271	9	added	add	VBN
cord-272051-arz8r204	271	10	and	and	CC
cord-272051-arz8r204	271	11	,	,	,
cord-272051-arz8r204	271	12	finally	finally	RB
cord-272051-arz8r204	271	13	,	,	,
cord-272051-arz8r204	271	14	the	the	DT
cord-272051-arz8r204	271	15	cells	cell	NNS
cord-272051-arz8r204	271	16	were	be	VBD
cord-272051-arz8r204	271	17	extensively	extensively	RB
cord-272051-arz8r204	271	18	washed	wash	VBN
cord-272051-arz8r204	271	19	and	and	CC
cord-272051-arz8r204	271	20	analyzed	analyze	VBN
cord-272051-arz8r204	271	21	by	by	IN
cord-272051-arz8r204	271	22	FACS	FACS	NNP
cord-272051-arz8r204	271	23	.	.	.
cord-272051-arz8r204	272	1	In	in	IN
cord-272051-arz8r204	272	2	the	the	DT
cord-272051-arz8r204	272	3	endocytosis	endocytosis	NN
cord-272051-arz8r204	272	4	assays	assay	NNS
cord-272051-arz8r204	272	5	,	,	,
cord-272051-arz8r204	272	6	the	the	DT
cord-272051-arz8r204	272	7	FACS	FACS	NNP
cord-272051-arz8r204	272	8	analysis	analysis	NN
cord-272051-arz8r204	272	9	was	be	VBD
cord-272051-arz8r204	272	10	carried	carry	VBN
cord-272051-arz8r204	272	11	out	out	RP
cord-272051-arz8r204	272	12	after	after	IN
cord-272051-arz8r204	272	13	incubation	incubation	NN
cord-272051-arz8r204	272	14	with	with	IN
cord-272051-arz8r204	272	15	trypsin	trypsin	NN
cord-272051-arz8r204	272	16	for	for	IN
cord-272051-arz8r204	272	17	15	15	CD
cord-272051-arz8r204	272	18	min	min	NN
cord-272051-arz8r204	272	19	at	at	IN
cord-272051-arz8r204	272	20	37	37	CD
cord-272051-arz8r204	272	21	°	°	NN
cord-272051-arz8r204	272	22	C	c	NN
cord-272051-arz8r204	272	23	.	.	.
cord-272051-arz8r204	273	1	Both	both	DT
cord-272051-arz8r204	273	2	cells	cell	NNS
cord-272051-arz8r204	273	3	and	and	CC
cord-272051-arz8r204	273	4	purified	purify	VBN
cord-272051-arz8r204	273	5	VLP	VLP	NNP
cord-272051-arz8r204	273	6	preparations	preparation	NNS
cord-272051-arz8r204	273	7	were	be	VBD
cord-272051-arz8r204	273	8	lysed	lyse	VBN
cord-272051-arz8r204	273	9	in	in	IN
cord-272051-arz8r204	273	10	PBS	PBS	NNP
cord-272051-arz8r204	273	11	,	,	,
cord-272051-arz8r204	273	12	1	1	CD
cord-272051-arz8r204	273	13	%	%	NN
cord-272051-arz8r204	273	14	Triton	Triton	NNP
cord-272051-arz8r204	273	15	X-100	x-100	NN
cord-272051-arz8r204	273	16	in	in	IN
cord-272051-arz8r204	273	17	the	the	DT
cord-272051-arz8r204	273	18	presence	presence	NN
cord-272051-arz8r204	273	19	of	of	IN
cord-272051-arz8r204	273	20	anti	anti	JJ
cord-272051-arz8r204	273	21	-	-	JJ
cord-272051-arz8r204	273	22	proteolytic	proteolytic	JJ
cord-272051-arz8r204	273	23	agents	agent	NNS
cord-272051-arz8r204	273	24	.	.	.
cord-272051-arz8r204	274	1	For	for	IN
cord-272051-arz8r204	274	2	the	the	DT
cord-272051-arz8r204	274	3	preparation	preparation	NN
cord-272051-arz8r204	274	4	of	of	IN
cord-272051-arz8r204	274	5	cytoplasmic	cytoplasmic	JJ
cord-272051-arz8r204	274	6	extracts	extract	NNS
cord-272051-arz8r204	274	7	,	,	,
cord-272051-arz8r204	274	8	whole	whole	JJ
cord-272051-arz8r204	274	9	cell	cell	NN
cord-272051-arz8r204	274	10	lysates	lysate	NNS
cord-272051-arz8r204	274	11	were	be	VBD
cord-272051-arz8r204	274	12	centrifuged	centrifuge	VBN
cord-272051-arz8r204	274	13	at	at	IN
cord-272051-arz8r204	274	14	6000×g	6000×g	CD
cord-272051-arz8r204	274	15	for	for	IN
cord-272051-arz8r204	274	16	10	10	CD
cord-272051-arz8r204	274	17	min	min	NN
cord-272051-arz8r204	274	18	at	at	IN
cord-272051-arz8r204	274	19	4	4	CD
cord-272051-arz8r204	274	20	°	°	NN
cord-272051-arz8r204	274	21	C	c	NN
cord-272051-arz8r204	274	22	,	,	,
cord-272051-arz8r204	274	23	and	and	CC
cord-272051-arz8r204	274	24	the	the	DT
cord-272051-arz8r204	274	25	supernatants	supernatant	NNS
cord-272051-arz8r204	274	26	frozen	freeze	VBN
cord-272051-arz8r204	274	27	at	at	IN
cord-272051-arz8r204	274	28	−80	−80	NNP
cord-272051-arz8r204	274	29	°	°	NN
cord-272051-arz8r204	274	30	C	C	NNP
cord-272051-arz8r204	274	31	.	.	.
cord-272051-arz8r204	275	1	Aliquots	Aliquots	NNP
cord-272051-arz8r204	275	2	of	of	IN
cord-272051-arz8r204	275	3	200	200	CD
cord-272051-arz8r204	275	4	ng	ng	NNP
cord-272051-arz8r204	275	5	HIV-1	HIV-1	NNP
cord-272051-arz8r204	275	6	CAp24	CAp24	:
cord-272051-arz8r204	275	7	equivalent	equivalent	NN
cord-272051-arz8r204	275	8	of	of	IN
cord-272051-arz8r204	275	9	VLPs	vlp	NNS
cord-272051-arz8r204	275	10	and	and	CC
cord-272051-arz8r204	275	11	of	of	IN
cord-272051-arz8r204	275	12	30	30	CD
cord-272051-arz8r204	275	13	μg	μg	NNS
cord-272051-arz8r204	275	14	of	of	IN
cord-272051-arz8r204	275	15	total	total	JJ
cord-272051-arz8r204	275	16	cell	cell	NN
cord-272051-arz8r204	275	17	proteins	protein	NNS
cord-272051-arz8r204	275	18	were	be	VBD
cord-272051-arz8r204	275	19	separated	separate	VBN
cord-272051-arz8r204	275	20	in	in	IN
cord-272051-arz8r204	275	21	10	10	CD
cord-272051-arz8r204	275	22	%	%	NN
cord-272051-arz8r204	275	23	SDS	sds	NN
cord-272051-arz8r204	275	24	-	-	HYPH
cord-272051-arz8r204	275	25	PAGE	PAGE	NNP
cord-272051-arz8r204	275	26	,	,	,
cord-272051-arz8r204	275	27	and	and	CC
cord-272051-arz8r204	275	28	then	then	RB
cord-272051-arz8r204	275	29	transferred	transfer	VBN
cord-272051-arz8r204	275	30	by	by	IN
cord-272051-arz8r204	275	31	electroblotting	electroblotte	VBG
cord-272051-arz8r204	275	32	on	on	IN
cord-272051-arz8r204	275	33	nitrocellulose	nitrocellulose	JJ
cord-272051-arz8r204	275	34	membranes	membrane	NNS
cord-272051-arz8r204	275	35	(	(	-LRB-
cord-272051-arz8r204	275	36	Sartorius	Sartorius	NNP
cord-272051-arz8r204	275	37	AG	AG	NNP
cord-272051-arz8r204	275	38	)	)	-RRB-
cord-272051-arz8r204	275	39	for	for	IN
cord-272051-arz8r204	275	40	60	60	CD
cord-272051-arz8r204	275	41	min	min	NN
cord-272051-arz8r204	275	42	at	at	IN
cord-272051-arz8r204	275	43	100	100	CD
cord-272051-arz8r204	275	44	V	v	NN
cord-272051-arz8r204	275	45	with	with	IN
cord-272051-arz8r204	275	46	a	a	DT
cord-272051-arz8r204	275	47	Bio	Bio	NNP
cord-272051-arz8r204	275	48	-	-	HYPH
cord-272051-arz8r204	275	49	Rad	Rad	NNP
cord-272051-arz8r204	275	50	transblot	transblot	NN
cord-272051-arz8r204	275	51	.	.	.
cord-272051-arz8r204	276	1	Nitrocellulose	nitrocellulose	NN
cord-272051-arz8r204	276	2	membranes	membrane	NNS
cord-272051-arz8r204	276	3	were	be	VBD
cord-272051-arz8r204	276	4	blocked	block	VBN
cord-272051-arz8r204	276	5	in	in	IN
cord-272051-arz8r204	276	6	3	3	CD
cord-272051-arz8r204	276	7	%	%	NN
cord-272051-arz8r204	276	8	bovine	bovine	JJ
cord-272051-arz8r204	276	9	serum	serum	NN
cord-272051-arz8r204	276	10	albumin	albumin	NN
cord-272051-arz8r204	276	11	(	(	-LRB-
cord-272051-arz8r204	276	12	BSA	BSA	NNP
cord-272051-arz8r204	276	13	)	)	-RRB-
cord-272051-arz8r204	276	14	fraction	fraction	NN
cord-272051-arz8r204	276	15	V	V	NNP
cord-272051-arz8r204	276	16	(	(	-LRB-
cord-272051-arz8r204	276	17	Sigma	Sigma	NNP
cord-272051-arz8r204	276	18	)	)	-RRB-
cord-272051-arz8r204	276	19	in	in	IN
cord-272051-arz8r204	276	20	TTBS	TTBS	NNP
cord-272051-arz8r204	276	21	/	/	SYM
cord-272051-arz8r204	276	22	EDTA	EDTA	NNP
cord-272051-arz8r204	276	23	(	(	-LRB-
cord-272051-arz8r204	276	24	10	10	CD
cord-272051-arz8r204	276	25	mM	mM	NNP
cord-272051-arz8r204	276	26	Tris	Tris	NNP
cord-272051-arz8r204	276	27	-	-	HYPH
cord-272051-arz8r204	276	28	HCl	HCl	NNP
cord-272051-arz8r204	276	29	,	,	,
cord-272051-arz8r204	276	30	pH	pH	NNP
cord-272051-arz8r204	276	31	7.4	7.4	CD
cord-272051-arz8r204	276	32	;	;	:
cord-272051-arz8r204	276	33	100	100	CD
cord-272051-arz8r204	276	34	mM	mm	CD
cord-272051-arz8r204	276	35	NaCl	nacl	NN
cord-272051-arz8r204	276	36	;	;	:
cord-272051-arz8r204	276	37	1	1	CD
cord-272051-arz8r204	276	38	mM	mm	CD
cord-272051-arz8r204	276	39	EDTA	edta	NN
cord-272051-arz8r204	276	40	;	;	:
cord-272051-arz8r204	276	41	0.1	0.1	CD
cord-272051-arz8r204	276	42	%	%	NN
cord-272051-arz8r204	276	43	Tween-20	Tween-20	NNP
cord-272051-arz8r204	276	44	)	)	-RRB-
cord-272051-arz8r204	276	45	for	for	IN
cord-272051-arz8r204	276	46	30	30	CD
cord-272051-arz8r204	276	47	min	min	NN
cord-272051-arz8r204	276	48	at	at	IN
cord-272051-arz8r204	276	49	room	room	NN
cord-272051-arz8r204	276	50	temperature	temperature	NN
cord-272051-arz8r204	276	51	,	,	,
cord-272051-arz8r204	276	52	then	then	RB
cord-272051-arz8r204	276	53	incubated	incubate	VBN
cord-272051-arz8r204	276	54	for	for	IN
cord-272051-arz8r204	276	55	1	1	CD
cord-272051-arz8r204	276	56	h	h	NN
cord-272051-arz8r204	276	57	at	at	IN
cord-272051-arz8r204	276	58	r.t	r.t	NNP
cord-272051-arz8r204	276	59	.	.	NNP
cord-272051-arz8r204	276	60	with	with	IN
cord-272051-arz8r204	276	61	specific	specific	JJ
cord-272051-arz8r204	276	62	antibodies	antibody	NNS
cord-272051-arz8r204	276	63	diluted	dilute	VBN
cord-272051-arz8r204	276	64	in	in	IN
cord-272051-arz8r204	276	65	1	1	CD
cord-272051-arz8r204	276	66	%	%	NN
cord-272051-arz8r204	276	67	BSA/	BSA/	NNP
cord-272051-arz8r204	276	68	TTBS	TTBS	NNP
cord-272051-arz8r204	276	69	-	-	HYPH
cord-272051-arz8r204	276	70	EDTA	EDTA	NNP
cord-272051-arz8r204	276	71	.	.	.
cord-272051-arz8r204	277	1	The	the	DT
cord-272051-arz8r204	277	2	following	follow	VBG
cord-272051-arz8r204	277	3	Abs	Abs	NNP
cord-272051-arz8r204	277	4	served	serve	VBD
cord-272051-arz8r204	277	5	for	for	IN
cord-272051-arz8r204	277	6	the	the	DT
cord-272051-arz8r204	277	7	revelation	revelation	NN
cord-272051-arz8r204	277	8	of	of	IN
cord-272051-arz8r204	277	9	both	both	CC
cord-272051-arz8r204	277	10	VLPand	VLPand	NNP
cord-272051-arz8r204	277	11	cell	cell	NN
cord-272051-arz8r204	277	12	-	-	HYPH
cord-272051-arz8r204	277	13	associated	associate	VBN
cord-272051-arz8r204	277	14	products	product	NNS
cord-272051-arz8r204	277	15	:	:	:
cord-272051-arz8r204	277	16	ARP	ARP	NNP
cord-272051-arz8r204	277	17	444	444	CD
cord-272051-arz8r204	277	18	sheep	sheep	NNS
cord-272051-arz8r204	277	19	anti	anti	NNP
cord-272051-arz8r204	277	20	-	-	NNP
cord-272051-arz8r204	277	21	Nef	Nef	NNP
cord-272051-arz8r204	277	22	antiserum	antiserum	NN
cord-272051-arz8r204	277	23	from	from	IN
cord-272051-arz8r204	277	24	Mark	Mark	NNP
cord-272051-arz8r204	277	25	Harris	Harris	NNP
cord-272051-arz8r204	277	26	,	,	,
cord-272051-arz8r204	277	27	University	University	NNP
cord-272051-arz8r204	277	28	of	of	IN
cord-272051-arz8r204	277	29	Leeds	Leeds	NNP
cord-272051-arz8r204	277	30	,	,	,
cord-272051-arz8r204	277	31	Leeds	Leeds	NNP
cord-272051-arz8r204	277	32	,	,	,
cord-272051-arz8r204	277	33	UK	UK	NNP
cord-272051-arz8r204	277	34	;	;	:
cord-272051-arz8r204	277	35	rabbit	rabbit	NN
cord-272051-arz8r204	277	36	polyclonal	polyclonal	JJ
cord-272051-arz8r204	277	37	anti	anti	NNP
cord-272051-arz8r204	277	38	-	-	JJ
cord-272051-arz8r204	277	39	VSV	VSV	NNP
cord-272051-arz8r204	277	40	-	-	HYPH
cord-272051-arz8r204	277	41	G	G	NNP
cord-272051-arz8r204	277	42	Abs	abs	NN
cord-272051-arz8r204	277	43	from	from	IN
cord-272051-arz8r204	277	44	Immunology	Immunology	NNP
cord-272051-arz8r204	277	45	Consultant	Consultant	NNP
cord-272051-arz8r204	277	46	Laboratories	Laboratories	NNPS
cord-272051-arz8r204	277	47	;	;	,
cord-272051-arz8r204	277	48	monoclonal	monoclonal	JJ
cord-272051-arz8r204	277	49	anti	anti	JJ
cord-272051-arz8r204	277	50	human	human	JJ
cord-272051-arz8r204	277	51	β	β	NN
cord-272051-arz8r204	277	52	-	-	HYPH
cord-272051-arz8r204	277	53	actin	actin	NN
cord-272051-arz8r204	277	54	from	from	IN
cord-272051-arz8r204	277	55	Amersham	Amersham	NNP
cord-272051-arz8r204	277	56	Pharmacia	Pharmacia	NNP
cord-272051-arz8r204	277	57	Biotech	Biotech	NNP
cord-272051-arz8r204	277	58	.	.	.
cord-272051-arz8r204	278	1	Immune	immune	JJ
cord-272051-arz8r204	278	2	complexes	complex	NNS
cord-272051-arz8r204	278	3	were	be	VBD
cord-272051-arz8r204	278	4	detected	detect	VBN
cord-272051-arz8r204	278	5	through	through	IN
cord-272051-arz8r204	278	6	horseradish	horseradish	NN
cord-272051-arz8r204	278	7	peroxidase	peroxidase	NN
cord-272051-arz8r204	278	8	-	-	HYPH
cord-272051-arz8r204	278	9	conjugated	conjugate	VBN
cord-272051-arz8r204	278	10	goat	goat	NN
cord-272051-arz8r204	278	11	anti	anti	JJ
cord-272051-arz8r204	278	12	-	-	JJ
cord-272051-arz8r204	278	13	sheep	sheep	JJ
cord-272051-arz8r204	278	14	,	,	,
cord-272051-arz8r204	278	15	anti	anti	JJ
cord-272051-arz8r204	278	16	-	-	JJ
cord-272051-arz8r204	278	17	rabbit	rabbit	JJ
cord-272051-arz8r204	278	18	(	(	-LRB-
cord-272051-arz8r204	278	19	both	both	DT
cord-272051-arz8r204	278	20	from	from	IN
cord-272051-arz8r204	278	21	Calbiochem	Calbiochem	NNP
cord-272051-arz8r204	278	22	)	)	-RRB-
cord-272051-arz8r204	278	23	and	and	CC
cord-272051-arz8r204	278	24	antimouse	antimouse	IN
cord-272051-arz8r204	278	25	Abs	Abs	NNP
cord-272051-arz8r204	278	26	(	(	-LRB-
cord-272051-arz8r204	278	27	NEN	NEN	NNP
cord-272051-arz8r204	278	28	)	)	-RRB-
cord-272051-arz8r204	278	29	,	,	,
cord-272051-arz8r204	278	30	followed	follow	VBN
cord-272051-arz8r204	278	31	by	by	IN
cord-272051-arz8r204	278	32	enhanced	enhance	VBN
cord-272051-arz8r204	278	33	chemioluminescence	chemioluminescence	NN
cord-272051-arz8r204	278	34	reaction	reaction	NN
cord-272051-arz8r204	278	35	(	(	-LRB-
cord-272051-arz8r204	278	36	Euroclone	Euroclone	NNP
cord-272051-arz8r204	278	37	)	)	-RRB-
cord-272051-arz8r204	278	38	.	.	.
cord-272051-arz8r204	279	1	The	the	DT
cord-272051-arz8r204	279	2	Lysosensor	Lysosensor	NNP
cord-272051-arz8r204	279	3	probe	probe	NN
cord-272051-arz8r204	279	4	DND-189	dnd-189	XX
cord-272051-arz8r204	280	1	(	(	-LRB-
cord-272051-arz8r204	280	2	Molecular	Molecular	NNP
cord-272051-arz8r204	280	3	Probes	Probes	NNPS
cord-272051-arz8r204	280	4	,	,	,
cord-272051-arz8r204	280	5	Invitrogen	Invitrogen	NNP
cord-272051-arz8r204	280	6	)	)	-RRB-
cord-272051-arz8r204	280	7	served	serve	VBD
cord-272051-arz8r204	280	8	to	to	TO
cord-272051-arz8r204	280	9	detect	detect	VB
cord-272051-arz8r204	280	10	possible	possible	JJ
cord-272051-arz8r204	280	11	changes	change	NNS
cord-272051-arz8r204	280	12	in	in	IN
cord-272051-arz8r204	280	13	the	the	DT
cord-272051-arz8r204	280	14	endosomal	endosomal	NNP
cord-272051-arz8r204	280	15	pH	ph	NN
cord-272051-arz8r204	280	16	upon	upon	IN
cord-272051-arz8r204	280	17	PI	pi	NN
cord-272051-arz8r204	280	18	treatment	treatment	NN
cord-272051-arz8r204	280	19	.	.	.
cord-272051-arz8r204	281	1	This	this	DT
cord-272051-arz8r204	281	2	is	be	VBZ
cord-272051-arz8r204	281	3	an	an	DT
cord-272051-arz8r204	281	4	acidotropic	acidotropic	NNP
cord-272051-arz8r204	281	5	probe	probe	NN
cord-272051-arz8r204	281	6	accumulating	accumulate	VBG
cord-272051-arz8r204	281	7	in	in	IN
cord-272051-arz8r204	281	8	acidic	acidic	JJ
cord-272051-arz8r204	281	9	organelles	organelle	NNS
cord-272051-arz8r204	281	10	which	which	WDT
cord-272051-arz8r204	281	11	exhibits	exhibit	VBZ
cord-272051-arz8r204	281	12	decreasing	decrease	VBG
cord-272051-arz8r204	281	13	fluorescence	fluorescence	NN
cord-272051-arz8r204	281	14	upon	upon	IN
cord-272051-arz8r204	281	15	pH	pH	NNP
cord-272051-arz8r204	281	16	increase	increase	NN
cord-272051-arz8r204	281	17	.	.	.
cord-272051-arz8r204	282	1	Cells	cell	NNS
cord-272051-arz8r204	282	2	pre	pre	VBP
cord-272051-arz8r204	282	3	-	-	VBN
cord-272051-arz8r204	282	4	treated	treat	VBN
cord-272051-arz8r204	282	5	with	with	IN
cord-272051-arz8r204	282	6	PIs	pi	NNS
cord-272051-arz8r204	282	7	or	or	CC
cord-272051-arz8r204	282	8	,	,	,
cord-272051-arz8r204	282	9	as	as	IN
cord-272051-arz8r204	282	10	control	control	NN
cord-272051-arz8r204	282	11	,	,	,
cord-272051-arz8r204	282	12	with	with	IN
cord-272051-arz8r204	282	13	bafilomycin	bafilomycin	NNP
cord-272051-arz8r204	282	14	A1	A1	NNP
cord-272051-arz8r204	282	15	(	(	-LRB-
cord-272051-arz8r204	282	16	Sigma	Sigma	NNP
cord-272051-arz8r204	282	17	-	-	HYPH
cord-272051-arz8r204	282	18	Aldrich	Aldrich	NNP
cord-272051-arz8r204	282	19	)	)	-RRB-
cord-272051-arz8r204	282	20	were	be	VBD
cord-272051-arz8r204	282	21	labeled	label	VBN
cord-272051-arz8r204	282	22	with	with	IN
cord-272051-arz8r204	282	23	1	1	CD
cord-272051-arz8r204	282	24	μM	μm	NN
cord-272051-arz8r204	282	25	of	of	IN
cord-272051-arz8r204	282	26	Lysosensor	Lysosensor	NNP
cord-272051-arz8r204	282	27	DND-189	DND-189	NNP
cord-272051-arz8r204	282	28	in	in	IN
cord-272051-arz8r204	282	29	complete	complete	JJ
cord-272051-arz8r204	282	30	medium	medium	NN
cord-272051-arz8r204	282	31	for	for	IN
cord-272051-arz8r204	282	32	30	30	CD
cord-272051-arz8r204	282	33	min	min	NN
cord-272051-arz8r204	282	34	in	in	IN
cord-272051-arz8r204	282	35	the	the	DT
cord-272051-arz8r204	282	36	presence	presence	NN
cord-272051-arz8r204	282	37	of	of	IN
cord-272051-arz8r204	282	38	the	the	DT
cord-272051-arz8r204	282	39	drugs	drug	NNS
cord-272051-arz8r204	282	40	.	.	.
cord-272051-arz8r204	283	1	Afterwards	afterwards	RB
cord-272051-arz8r204	283	2	,	,	,
cord-272051-arz8r204	283	3	cells	cell	NNS
cord-272051-arz8r204	283	4	were	be	VBD
cord-272051-arz8r204	283	5	extensively	extensively	RB
cord-272051-arz8r204	283	6	washed	wash	VBN
cord-272051-arz8r204	283	7	,	,	,
cord-272051-arz8r204	283	8	fixed	fix	VBN
cord-272051-arz8r204	283	9	,	,	,
cord-272051-arz8r204	283	10	and	and	CC
cord-272051-arz8r204	283	11	fluorescence	fluorescence	NN
cord-272051-arz8r204	283	12	evaluated	evaluate	VBN
cord-272051-arz8r204	283	13	by	by	IN
cord-272051-arz8r204	283	14	FACS	FACS	NNP
cord-272051-arz8r204	283	15	analysis	analysis	NN
cord-272051-arz8r204	283	16	.	.	.
cord-272051-arz8r204	284	1	When	when	WRB
cord-272051-arz8r204	284	2	appropriate	appropriate	JJ
cord-272051-arz8r204	284	3	,	,	,
cord-272051-arz8r204	284	4	data	datum	NNS
cord-272051-arz8r204	284	5	are	be	VBP
cord-272051-arz8r204	284	6	presented	present	VBN
cord-272051-arz8r204	284	7	as	as	IN
cord-272051-arz8r204	284	8	mean	mean	JJ
cord-272051-arz8r204	284	9	+	+	CC
cord-272051-arz8r204	284	10	standard	standard	JJ
cord-272051-arz8r204	284	11	deviation	deviation	NN
cord-272051-arz8r204	284	12	values	value	NNS
cord-272051-arz8r204	284	13	(	(	-LRB-
cord-272051-arz8r204	284	14	SD	sd	NN
cord-272051-arz8r204	284	15	)	)	-RRB-
cord-272051-arz8r204	284	16	.	.	.
cord-272051-arz8r204	285	1	In	in	IN
cord-272051-arz8r204	285	2	some	some	DT
cord-272051-arz8r204	285	3	instances	instance	NNS
cord-272051-arz8r204	285	4	,	,	,
cord-272051-arz8r204	285	5	statistical	statistical	JJ
cord-272051-arz8r204	285	6	analysis	analysis	NN
cord-272051-arz8r204	285	7	was	be	VBD
cord-272051-arz8r204	285	8	performed	perform	VBN
cord-272051-arz8r204	285	9	according	accord	VBG
cord-272051-arz8r204	285	10	to	to	IN
cord-272051-arz8r204	285	11	paired	pair	VBN
cord-272051-arz8r204	285	12	Student	Student	NNP
cord-272051-arz8r204	285	13	's	's	POS
cord-272051-arz8r204	285	14	t	t	NN
cord-272051-arz8r204	285	15	-	-	HYPH
cord-272051-arz8r204	285	16	Test	Test	NNP
cord-272051-arz8r204	285	17	,	,	,
cord-272051-arz8r204	285	18	and	and	CC
cord-272051-arz8r204	285	19	confirmed	confirm	VBD
cord-272051-arz8r204	285	20	using	use	VBG
cord-272051-arz8r204	285	21	the	the	DT
cord-272051-arz8r204	285	22	non	non	JJ
cord-272051-arz8r204	285	23	-	-	JJ
cord-272051-arz8r204	285	24	parametric	parametric	JJ
cord-272051-arz8r204	285	25	Wilcoxon	Wilcoxon	NNP
cord-272051-arz8r204	285	26	rank	rank	NN
cord-272051-arz8r204	285	27	sum	sum	NN
cord-272051-arz8r204	285	28	test	test	NN
cord-272051-arz8r204	285	29	.	.	.
cord-272051-arz8r204	286	1	P	p	NN
cord-272051-arz8r204	286	2	-	-	HYPH
cord-272051-arz8r204	286	3	values	value	NNS
cord-272051-arz8r204	286	4	b0.05	b0.05	NNP
cord-272051-arz8r204	286	5	were	be	VBD
cord-272051-arz8r204	286	6	considered	consider	VBN
cord-272051-arz8r204	286	7	significant	significant	JJ
cord-272051-arz8r204	286	8	.	.	.
cord-272051-arz8r204	287	1	An	an	DT
cord-272051-arz8r204	287	2	inhibitor	inhibitor	NN
cord-272051-arz8r204	287	3	of	of	IN
cord-272051-arz8r204	287	4	HIV-1	HIV-1	NNP
cord-272051-arz8r204	287	5	protease	protease	NN
cord-272051-arz8r204	287	6	modulates	modulate	VBZ
cord-272051-arz8r204	287	7	proteasome	proteasome	JJ
cord-272051-arz8r204	287	8	activity	activity	NN
cord-272051-arz8r204	287	9	,	,	,
cord-272051-arz8r204	287	10	antigen	antigen	NN
cord-272051-arz8r204	287	11	presentation	presentation	NN
cord-272051-arz8r204	287	12	,	,	,
cord-272051-arz8r204	287	13	and	and	CC
cord-272051-arz8r204	287	14	T	T	NNP
cord-272051-arz8r204	287	15	cell	cell	NN
cord-272051-arz8r204	287	16	responses	response	NNS
cord-272051-arz8r204	288	1	In	in	IN
cord-272051-arz8r204	288	2	vitro	vitro	FW
cord-272051-arz8r204	288	3	and	and	CC
cord-272051-arz8r204	288	4	in	in	IN
cord-272051-arz8r204	288	5	vivo	vivo	FW
cord-272051-arz8r204	288	6	effects	effect	NNS
cord-272051-arz8r204	288	7	of	of	IN
cord-272051-arz8r204	288	8	HIV	HIV	NNP
cord-272051-arz8r204	288	9	protease	protease	NN
cord-272051-arz8r204	288	10	inhibitors	inhibitor	NNS
cord-272051-arz8r204	288	11	on	on	IN
cord-272051-arz8r204	288	12	apoptosis	apoptosis	NN
cord-272051-arz8r204	288	13	Cathepsin	Cathepsin	NNP
cord-272051-arz8r204	288	14	L	L	NNP
cord-272051-arz8r204	288	15	functionally	functionally	RB
cord-272051-arz8r204	288	16	cleaves	cleave	VBZ
cord-272051-arz8r204	288	17	the	the	DT
cord-272051-arz8r204	288	18	severe	severe	JJ
cord-272051-arz8r204	288	19	acute	acute	JJ
cord-272051-arz8r204	288	20	respiratory	respiratory	JJ
cord-272051-arz8r204	288	21	syndrome	syndrome	NN
cord-272051-arz8r204	288	22	coronavirus	coronavirus	NN
cord-272051-arz8r204	288	23	class	class	NN
cord-272051-arz8r204	288	24	I	-PRON-	PRP
cord-272051-arz8r204	288	25	fusion	fusion	NN
cord-272051-arz8r204	288	26	protein	protein	NN
cord-272051-arz8r204	288	27	upstream	upstream	RB
cord-272051-arz8r204	288	28	of	of	IN
cord-272051-arz8r204	288	29	rather	rather	RB
cord-272051-arz8r204	288	30	than	than	IN
cord-272051-arz8r204	288	31	adjacent	adjacent	JJ
cord-272051-arz8r204	288	32	to	to	IN
cord-272051-arz8r204	288	33	the	the	DT
cord-272051-arz8r204	288	34	fusion	fusion	NN
cord-272051-arz8r204	288	35	peptide	peptide	NN
cord-272051-arz8r204	288	36	Protease	protease	NN
cord-272051-arz8r204	288	37	inhibitor	inhibitor	NN
cord-272051-arz8r204	288	38	treatments	treatment	NNS
cord-272051-arz8r204	289	1	reveal	reveal	VB
cord-272051-arz8r204	289	2	specific	specific	JJ
cord-272051-arz8r204	289	3	involvement	involvement	NN
cord-272051-arz8r204	289	4	of	of	IN
cord-272051-arz8r204	289	5	matrix	matrix	NN
cord-272051-arz8r204	289	6	metalloproteinase-9	metalloproteinase-9	NNP
cord-272051-arz8r204	289	7	in	in	IN
cord-272051-arz8r204	289	8	human	human	JJ
cord-272051-arz8r204	289	9	adipocyte	adipocyte	NN
cord-272051-arz8r204	289	10	differentiation	differentiation	NN
cord-272051-arz8r204	289	11	Identification	Identification	NNP
cord-272051-arz8r204	289	12	of	of	IN
cord-272051-arz8r204	289	13	host	host	NN
cord-272051-arz8r204	289	14	proteins	protein	NNS
cord-272051-arz8r204	289	15	required	require	VBN
cord-272051-arz8r204	289	16	for	for	IN
cord-272051-arz8r204	289	17	HIV	HIV	NNP
cord-272051-arz8r204	289	18	infection	infection	NN
cord-272051-arz8r204	289	19	through	through	IN
cord-272051-arz8r204	289	20	a	a	DT
cord-272051-arz8r204	289	21	functional	functional	JJ
cord-272051-arz8r204	289	22	genomic	genomic	NN
cord-272051-arz8r204	289	23	screen	screen	NN
cord-272051-arz8r204	289	24	Dyslipidaemia	Dyslipidaemia	NNP
cord-272051-arz8r204	289	25	associated	associate	VBN
cord-272051-arz8r204	289	26	with	with	IN
cord-272051-arz8r204	289	27	antiretroviral	antiretroviral	JJ
cord-272051-arz8r204	289	28	therapy	therapy	NN
cord-272051-arz8r204	289	29	in	in	IN
cord-272051-arz8r204	289	30	HIV	HIV	NNP
cord-272051-arz8r204	289	31	-	-	HYPH
cord-272051-arz8r204	289	32	infected	infect	VBN
cord-272051-arz8r204	289	33	patients	patient	NNS
cord-272051-arz8r204	289	34	Identification	Identification	NNP
cord-272051-arz8r204	289	35	of	of	IN
cord-272051-arz8r204	289	36	host	host	NN
cord-272051-arz8r204	289	37	factors	factor	NNS
cord-272051-arz8r204	289	38	involved	involve	VBN
cord-272051-arz8r204	289	39	in	in	IN
cord-272051-arz8r204	289	40	borna	borna	NNP
cord-272051-arz8r204	289	41	disease	disease	NNP
cord-272051-arz8r204	289	42	virus	virus	NN
cord-272051-arz8r204	289	43	cell	cell	NN
cord-272051-arz8r204	289	44	entry	entry	NN
cord-272051-arz8r204	289	45	through	through	IN
cord-272051-arz8r204	289	46	a	a	DT
cord-272051-arz8r204	289	47	small	small	JJ
cord-272051-arz8r204	289	48	interfering	interfere	VBG
cord-272051-arz8r204	289	49	RNA	RNA	NNP
cord-272051-arz8r204	289	50	functional	functional	JJ
cord-272051-arz8r204	289	51	genetic	genetic	JJ
cord-272051-arz8r204	289	52	screen	screen	NN
cord-272051-arz8r204	290	1	In	in	IN
cord-272051-arz8r204	290	2	vivo	vivo	NN
cord-272051-arz8r204	290	3	emergence	emergence	NN
cord-272051-arz8r204	290	4	of	of	IN
cord-272051-arz8r204	290	5	HIV-1	HIV-1	NNP
cord-272051-arz8r204	290	6	variants	variant	NNS
cord-272051-arz8r204	290	7	resistant	resistant	JJ
cord-272051-arz8r204	290	8	to	to	IN
cord-272051-arz8r204	290	9	multiple	multiple	JJ
cord-272051-arz8r204	290	10	protease	protease	NN
cord-272051-arz8r204	290	11	inhibitors	inhibitor	NNS
cord-272051-arz8r204	290	12	Inhibition	inhibition	NN
cord-272051-arz8r204	290	13	of	of	IN
cord-272051-arz8r204	290	14	human	human	JJ
cord-272051-arz8r204	290	15	preadipocyte	preadipocyte	NN
cord-272051-arz8r204	291	1	proteasomal	proteasomal	JJ
cord-272051-arz8r204	291	2	activity	activity	NN
cord-272051-arz8r204	291	3	by	by	IN
cord-272051-arz8r204	291	4	HIV	HIV	NNP
cord-272051-arz8r204	291	5	protease	protease	NN
cord-272051-arz8r204	291	6	inhibitors	inhibitor	NNS
cord-272051-arz8r204	291	7	or	or	CC
cord-272051-arz8r204	291	8	specific	specific	JJ
cord-272051-arz8r204	291	9	inhibitor	inhibitor	NN
cord-272051-arz8r204	291	10	lactacystin	lactacystin	RB
cord-272051-arz8r204	291	11	leads	lead	VBZ
cord-272051-arz8r204	291	12	to	to	IN
cord-272051-arz8r204	291	13	a	a	DT
cord-272051-arz8r204	291	14	defect	defect	NN
cord-272051-arz8r204	291	15	in	in	IN
cord-272051-arz8r204	291	16	adipogenesis	adipogenesis	NN
cord-272051-arz8r204	291	17	,	,	,
cord-272051-arz8r204	291	18	which	which	WDT
cord-272051-arz8r204	291	19	involves	involve	VBZ
cord-272051-arz8r204	291	20	matrix	matrix	NN
cord-272051-arz8r204	291	21	metalloproteinase-9	metalloproteinase-9	NNP
cord-272051-arz8r204	291	22	An	an	DT
cord-272051-arz8r204	291	23	HIV	HIV	NNP
cord-272051-arz8r204	291	24	protease	protease	NN
cord-272051-arz8r204	291	25	inhibitor	inhibitor	NN
cord-272051-arz8r204	291	26	,	,	,
cord-272051-arz8r204	291	27	ritonavir	ritonavir	NNP
cord-272051-arz8r204	291	28	targets	target	VBZ
cord-272051-arz8r204	291	29	the	the	DT
cord-272051-arz8r204	291	30	nuclear	nuclear	JJ
cord-272051-arz8r204	291	31	factor	factor	NN
cord-272051-arz8r204	291	32	-	-	:
cord-272051-arz8r204	291	33	kappaB	kappaB	NNP
cord-272051-arz8r204	291	34	and	and	CC
cord-272051-arz8r204	291	35	inhibits	inhibit	VBZ
cord-272051-arz8r204	291	36	the	the	DT
cord-272051-arz8r204	291	37	tumor	tumor	NN
cord-272051-arz8r204	291	38	growth	growth	NN
cord-272051-arz8r204	291	39	and	and	CC
cord-272051-arz8r204	291	40	infiltration	infiltration	NN
cord-272051-arz8r204	291	41	of	of	IN
cord-272051-arz8r204	291	42	EBVpositive	EBVpositive	NNP
cord-272051-arz8r204	291	43	lymphoblastoid	lymphoblastoid	NNP
cord-272051-arz8r204	291	44	B	b	NN
cord-272051-arz8r204	291	45	cells	cell	NNS
cord-272051-arz8r204	292	1	HIV-1	HIV-1	NNP
cord-272051-arz8r204	292	2	Nef	Nef	NNP
cord-272051-arz8r204	292	3	activates	activate	VBZ
cord-272051-arz8r204	292	4	STAT1	stat1	NN
cord-272051-arz8r204	292	5	in	in	IN
cord-272051-arz8r204	292	6	human	human	JJ
cord-272051-arz8r204	292	7	monocytes	monocyte	NNS
cord-272051-arz8r204	292	8	/	/	SYM
cord-272051-arz8r204	292	9	macrophages	macrophage	NNS
cord-272051-arz8r204	292	10	through	through	IN
cord-272051-arz8r204	292	11	the	the	DT
cord-272051-arz8r204	292	12	release	release	NN
cord-272051-arz8r204	292	13	of	of	IN
cord-272051-arz8r204	292	14	soluble	soluble	JJ
cord-272051-arz8r204	292	15	factors	factor	NNS
cord-272051-arz8r204	292	16	HIV	HIV	NNP
cord-272051-arz8r204	292	17	-	-	HYPH
cord-272051-arz8r204	292	18	protease	protease	NN
cord-272051-arz8r204	292	19	inhibitors	inhibitor	NNS
cord-272051-arz8r204	293	1	Vesicular	vesicular	JJ
cord-272051-arz8r204	293	2	stomatitis	stomatitis	NN
cord-272051-arz8r204	293	3	virus	virus	NN
cord-272051-arz8r204	293	4	glycoprotein	glycoprotein	NN
cord-272051-arz8r204	293	5	mutations	mutation	NNS
cord-272051-arz8r204	293	6	that	that	WDT
cord-272051-arz8r204	293	7	affect	affect	VBP
cord-272051-arz8r204	293	8	membrane	membrane	NN
cord-272051-arz8r204	293	9	fusion	fusion	NN
cord-272051-arz8r204	293	10	activity	activity	NN
cord-272051-arz8r204	293	11	and	and	CC
cord-272051-arz8r204	293	12	abolish	abolish	VB
cord-272051-arz8r204	293	13	virus	virus	NN
cord-272051-arz8r204	293	14	infectivity	infectivity	NN
cord-272051-arz8r204	293	15	vitro	vitro	FW
cord-272051-arz8r204	293	16	and	and	CC
cord-272051-arz8r204	293	17	in	in	IN
cord-272051-arz8r204	293	18	vivo	vivo	NN
cord-272051-arz8r204	293	19	activities	activity	NNS
cord-272051-arz8r204	293	20	of	of	IN
cord-272051-arz8r204	293	21	anti	anti	JJ
cord-272051-arz8r204	293	22	-	-	JJ
cord-272051-arz8r204	293	23	influenza	influenza	JJ
cord-272051-arz8r204	293	24	virus	virus	NN
cord-272051-arz8r204	293	25	compound	compound	NN
cord-272051-arz8r204	294	1	T-705	T-705	NNP
cord-272051-arz8r204	294	2	A	a	DT
cord-272051-arz8r204	294	3	new	new	JJ
cord-272051-arz8r204	294	4	reporter	reporter	NN
cord-272051-arz8r204	294	5	cell	cell	NN
cord-272051-arz8r204	294	6	line	line	NN
cord-272051-arz8r204	294	7	to	to	TO
cord-272051-arz8r204	294	8	monitor	monitor	VB
cord-272051-arz8r204	294	9	HIV	HIV	NNP
cord-272051-arz8r204	294	10	infection	infection	NN
cord-272051-arz8r204	294	11	and	and	CC
cord-272051-arz8r204	294	12	drug	drug	NN
cord-272051-arz8r204	294	13	susceptibility	susceptibility	NN
cord-272051-arz8r204	294	14	in	in	IN
cord-272051-arz8r204	294	15	vitro	vitro	FW
cord-272051-arz8r204	294	16	Effect	effect	NN
cord-272051-arz8r204	294	17	of	of	IN
cord-272051-arz8r204	294	18	repeated	repeat	VBN
cord-272051-arz8r204	294	19	inoculation	inoculation	NN
cord-272051-arz8r204	294	20	of	of	IN
cord-272051-arz8r204	294	21	interferon	interferon	NN
cord-272051-arz8r204	294	22	preparations	preparation	NNS
cord-272051-arz8r204	294	23	on	on	IN
cord-272051-arz8r204	294	24	infection	infection	NN
cord-272051-arz8r204	294	25	of	of	IN
cord-272051-arz8r204	294	26	mice	mouse	NNS
cord-272051-arz8r204	294	27	with	with	IN
cord-272051-arz8r204	294	28	encephalomyocarditis	encephalomyocarditis	NNP
cord-272051-arz8r204	294	29	virus	virus	NN
cord-272051-arz8r204	294	30	Drosophila	Drosophila	NNP
cord-272051-arz8r204	294	31	RNAi	RNAi	NNS
cord-272051-arz8r204	294	32	screen	screen	NN
cord-272051-arz8r204	294	33	identifies	identify	VBZ
cord-272051-arz8r204	294	34	host	host	NN
cord-272051-arz8r204	294	35	genes	gene	NNS
cord-272051-arz8r204	294	36	important	important	JJ
cord-272051-arz8r204	294	37	for	for	IN
cord-272051-arz8r204	294	38	influenza	influenza	NN
cord-272051-arz8r204	294	39	virus	virus	NN
cord-272051-arz8r204	294	40	replication	replication	NN
cord-272051-arz8r204	294	41	Partial	partial	JJ
cord-272051-arz8r204	294	42	inhibition	inhibition	NN
cord-272051-arz8r204	294	43	of	of	IN
cord-272051-arz8r204	294	44	the	the	DT
cord-272051-arz8r204	294	45	human	human	JJ
cord-272051-arz8r204	294	46	immunodeficiency	immunodeficiency	NN
cord-272051-arz8r204	294	47	virus	virus	NN
cord-272051-arz8r204	294	48	type	type	NN
cord-272051-arz8r204	294	49	1	1	CD
cord-272051-arz8r204	294	50	protease	protease	NN
cord-272051-arz8r204	294	51	results	result	NNS
cord-272051-arz8r204	294	52	in	in	IN
cord-272051-arz8r204	294	53	aberrant	aberrant	JJ
cord-272051-arz8r204	294	54	virus	virus	NN
cord-272051-arz8r204	294	55	assembly	assembly	NN
cord-272051-arz8r204	294	56	and	and	CC
cord-272051-arz8r204	294	57	the	the	DT
cord-272051-arz8r204	294	58	formation	formation	NN
cord-272051-arz8r204	294	59	of	of	IN
cord-272051-arz8r204	294	60	noninfectious	noninfectious	JJ
cord-272051-arz8r204	294	61	particles	particle	NNS
cord-272051-arz8r204	294	62	Potent	potent	JJ
cord-272051-arz8r204	294	63	suppression	suppression	NN
cord-272051-arz8r204	294	64	of	of	IN
cord-272051-arz8r204	294	65	HIV-1	HIV-1	NNP
cord-272051-arz8r204	294	66	replication	replication	NN
cord-272051-arz8r204	294	67	in	in	IN
cord-272051-arz8r204	294	68	humans	human	NNS
cord-272051-arz8r204	294	69	by	by	IN
cord-272051-arz8r204	294	70	T-20	T-20	NNP
cord-272051-arz8r204	294	71	,	,	,
cord-272051-arz8r204	294	72	a	a	DT
cord-272051-arz8r204	294	73	peptide	peptide	JJ
cord-272051-arz8r204	294	74	inhibitor	inhibitor	NN
cord-272051-arz8r204	294	75	of	of	IN
cord-272051-arz8r204	294	76	gp41-mediated	gp41-mediated	JJ
cord-272051-arz8r204	294	77	virus	virus	NN
cord-272051-arz8r204	294	78	entry	entry	NN
cord-272051-arz8r204	294	79	Activation	activation	NN
cord-272051-arz8r204	294	80	of	of	IN
cord-272051-arz8r204	294	81	influenza	influenza	NN
cord-272051-arz8r204	294	82	A	a	DT
cord-272051-arz8r204	294	83	viruses	virus	NNS
cord-272051-arz8r204	294	84	by	by	IN
cord-272051-arz8r204	294	85	trypsin	trypsin	NN
cord-272051-arz8r204	294	86	treatment	treatment	NN
cord-272051-arz8r204	294	87	RNA	RNA	NNP
cord-272051-arz8r204	294	88	interference	interference	NN
cord-272051-arz8r204	294	89	screen	screen	NN
cord-272051-arz8r204	294	90	for	for	IN
cord-272051-arz8r204	294	91	human	human	JJ
cord-272051-arz8r204	294	92	genes	gene	NNS
cord-272051-arz8r204	294	93	associated	associate	VBN
cord-272051-arz8r204	294	94	with	with	IN
cord-272051-arz8r204	294	95	West	West	NNP
cord-272051-arz8r204	294	96	Nile	Nile	NNP
cord-272051-arz8r204	294	97	virus	virus	NN
cord-272051-arz8r204	294	98	infection	infection	NN
cord-272051-arz8r204	294	99	Ritonavir	Ritonavir	NNP
cord-272051-arz8r204	294	100	blocks	block	VBZ
cord-272051-arz8r204	294	101	AKT	AKT	NNP
cord-272051-arz8r204	294	102	signaling	signal	VBG
cord-272051-arz8r204	294	103	,	,	,
cord-272051-arz8r204	294	104	activates	activate	VBZ
cord-272051-arz8r204	294	105	apoptosis	apoptosis	NN
cord-272051-arz8r204	294	106	and	and	CC
cord-272051-arz8r204	294	107	inhibits	inhibit	VBZ
cord-272051-arz8r204	294	108	migration	migration	NN
cord-272051-arz8r204	294	109	and	and	CC
cord-272051-arz8r204	294	110	invasion	invasion	NN
cord-272051-arz8r204	294	111	in	in	IN
cord-272051-arz8r204	294	112	ovarian	ovarian	JJ
cord-272051-arz8r204	294	113	cancer	cancer	NN
cord-272051-arz8r204	294	114	cells	cell	NNS
cord-272051-arz8r204	294	115	Enhancement	enhancement	NN
cord-272051-arz8r204	294	116	of	of	IN
cord-272051-arz8r204	294	117	the	the	DT
cord-272051-arz8r204	294	118	infectivity	infectivity	NN
cord-272051-arz8r204	294	119	of	of	IN
cord-272051-arz8r204	294	120	influenza	influenza	NN
cord-272051-arz8r204	294	121	A	a	NN
cord-272051-arz8r204	294	122	and	and	CC
cord-272051-arz8r204	294	123	B	b	NN
cord-272051-arz8r204	294	124	viruses	virus	NNS
cord-272051-arz8r204	294	125	by	by	IN
cord-272051-arz8r204	294	126	proteolytic	proteolytic	JJ
cord-272051-arz8r204	294	127	cleavage	cleavage	NN
cord-272051-arz8r204	294	128	of	of	IN
cord-272051-arz8r204	294	129	the	the	DT
cord-272051-arz8r204	294	130	hemagglutinin	hemagglutinin	NN
cord-272051-arz8r204	294	131	polypeptide	polypeptide	NN
cord-272051-arz8r204	294	132	Mechanism	Mechanism	NNP
cord-272051-arz8r204	294	133	of	of	IN
cord-272051-arz8r204	294	134	interferon	interferon	NN
cord-272051-arz8r204	294	135	action	action	NN
cord-272051-arz8r204	294	136	:	:	:
cord-272051-arz8r204	294	137	inhibition	inhibition	NN
cord-272051-arz8r204	294	138	of	of	IN
cord-272051-arz8r204	294	139	vesicular	vesicular	JJ
cord-272051-arz8r204	294	140	stomatitis	stomatitis	NN
cord-272051-arz8r204	294	141	virus	virus	NN
cord-272051-arz8r204	294	142	replication	replication	NN
cord-272051-arz8r204	294	143	in	in	IN
cord-272051-arz8r204	294	144	human	human	JJ
cord-272051-arz8r204	294	145	amnion	amnion	NN
cord-272051-arz8r204	294	146	U	u	CD
cord-272051-arz8r204	294	147	cells	cell	NNS
cord-272051-arz8r204	294	148	by	by	IN
cord-272051-arz8r204	294	149	cloned	clone	VBN
cord-272051-arz8r204	294	150	human	human	JJ
cord-272051-arz8r204	294	151	leukocyte	leukocyte	NN
cord-272051-arz8r204	294	152	interferon	interferon	NN
cord-272051-arz8r204	294	153	.	.	.
cord-272051-arz8r204	295	1	I.	I.	NNP
cord-272051-arz8r204	295	2	Effect	Effect	NNP
cord-272051-arz8r204	295	3	on	on	IN
cord-272051-arz8r204	295	4	early	early	JJ
cord-272051-arz8r204	295	5	and	and	CC
cord-272051-arz8r204	295	6	late	late	JJ
cord-272051-arz8r204	295	7	stages	stage	NNS
cord-272051-arz8r204	295	8	of	of	IN
cord-272051-arz8r204	295	9	the	the	DT
cord-272051-arz8r204	295	10	viral	viral	JJ
cord-272051-arz8r204	295	11	multiplication	multiplication	NN
cord-272051-arz8r204	295	12	cycle	cycle	NN
cord-272051-arz8r204	295	13	Generation	generation	NN
cord-272051-arz8r204	295	14	and	and	CC
cord-272051-arz8r204	295	15	characterization	characterization	NN
cord-272051-arz8r204	295	16	of	of	IN
cord-272051-arz8r204	295	17	a	a	DT
cord-272051-arz8r204	295	18	stable	stable	JJ
cord-272051-arz8r204	295	19	cell	cell	NN
cord-272051-arz8r204	295	20	population	population	NN
cord-272051-arz8r204	295	21	releasing	release	VBG
cord-272051-arz8r204	295	22	fluorescent	fluorescent	JJ
cord-272051-arz8r204	295	23	HIV-1-based	hiv-1-base	VBN
cord-272051-arz8r204	295	24	virus	virus	NN
cord-272051-arz8r204	295	25	like	like	IN
cord-272051-arz8r204	295	26	particles	particle	NNS
cord-272051-arz8r204	295	27	in	in	IN
cord-272051-arz8r204	295	28	an	an	DT
cord-272051-arz8r204	295	29	inducible	inducible	JJ
cord-272051-arz8r204	295	30	way	way	NN
cord-272051-arz8r204	295	31	Human	human	JJ
cord-272051-arz8r204	295	32	immunodeficiency	immunodeficiency	NN
cord-272051-arz8r204	295	33	virus	virus	NN
cord-272051-arz8r204	295	34	type	type	NN
cord-272051-arz8r204	295	35	1	1	CD
cord-272051-arz8r204	295	36	(	(	-LRB-
cord-272051-arz8r204	295	37	HIV-1	HIV-1	NNP
cord-272051-arz8r204	295	38	)	)	-RRB-
cord-272051-arz8r204	295	39	protease	protease	NN
cord-272051-arz8r204	295	40	inhibitors	inhibitor	NNS
cord-272051-arz8r204	295	41	block	block	VBP
cord-272051-arz8r204	295	42	cell	cell	NN
cord-272051-arz8r204	295	43	-	-	HYPH
cord-272051-arz8r204	295	44	to	to	IN
cord-272051-arz8r204	295	45	-	-	HYPH
cord-272051-arz8r204	295	46	cell	cell	NN
cord-272051-arz8r204	295	47	HIV-1	HIV-1	NNP
cord-272051-arz8r204	295	48	endocytosis	endocytosis	NN
cord-272051-arz8r204	295	49	in	in	IN
cord-272051-arz8r204	295	50	dendritic	dendritic	JJ
cord-272051-arz8r204	295	51	cells	cell	NNS
cord-272051-arz8r204	296	1	Different	different	JJ
cord-272051-arz8r204	296	2	effect	effect	NN
cord-272051-arz8r204	296	3	of	of	IN
cord-272051-arz8r204	296	4	proteasome	proteasome	VBN
cord-272051-arz8r204	296	5	inhibition	inhibition	NN
cord-272051-arz8r204	296	6	on	on	IN
cord-272051-arz8r204	296	7	vesicular	vesicular	JJ
cord-272051-arz8r204	296	8	stomatitis	stomatitis	NN
cord-272051-arz8r204	296	9	virus	virus	NN
cord-272051-arz8r204	296	10	and	and	CC
cord-272051-arz8r204	296	11	poliovirus	poliovirus	NN
cord-272051-arz8r204	296	12	replication	replication	NN
cord-272051-arz8r204	296	13	Identification	identification	NN
cord-272051-arz8r204	296	14	of	of	IN
cord-272051-arz8r204	296	15	host	host	NN
cord-272051-arz8r204	296	16	genes	gene	NNS
cord-272051-arz8r204	296	17	involved	involve	VBN
cord-272051-arz8r204	296	18	in	in	IN
cord-272051-arz8r204	296	19	hepatitis	hepatitis	NN
cord-272051-arz8r204	296	20	C	C	NNP
cord-272051-arz8r204	296	21	virus	virus	NN
cord-272051-arz8r204	296	22	replication	replication	NN
cord-272051-arz8r204	296	23	by	by	IN
cord-272051-arz8r204	296	24	small	small	JJ
cord-272051-arz8r204	296	25	interfering	interfere	VBG
cord-272051-arz8r204	296	26	RNA	RNA	NNP
cord-272051-arz8r204	296	27	technology	technology	NN
cord-272051-arz8r204	296	28	UnPAKing	UnPAKing	NNP
cord-272051-arz8r204	296	29	"	"	``
cord-272051-arz8r204	296	30	human	human	JJ
cord-272051-arz8r204	296	31	immunodeficiency	immunodeficiency	NN
cord-272051-arz8r204	296	32	virus	virus	NN
cord-272051-arz8r204	296	33	(	(	-LRB-
cord-272051-arz8r204	296	34	HIV	HIV	NNP
cord-272051-arz8r204	296	35	)	)	-RRB-
cord-272051-arz8r204	296	36	replication	replication	NN
cord-272051-arz8r204	296	37	:	:	:
cord-272051-arz8r204	296	38	using	use	VBG
cord-272051-arz8r204	296	39	small	small	JJ
cord-272051-arz8r204	296	40	interfering	interfere	VBG
cord-272051-arz8r204	296	41	RNA	RNA	NNP
cord-272051-arz8r204	296	42	screening	screening	NN
cord-272051-arz8r204	296	43	to	to	TO
cord-272051-arz8r204	296	44	identify	identify	VB
cord-272051-arz8r204	296	45	novel	novel	JJ
cord-272051-arz8r204	296	46	cofactors	cofactor	NNS
cord-272051-arz8r204	296	47	and	and	CC
cord-272051-arz8r204	296	48	elucidate	elucidate	VB
cord-272051-arz8r204	296	49	the	the	DT
cord-272051-arz8r204	296	50	role	role	NN
cord-272051-arz8r204	296	51	of	of	IN
cord-272051-arz8r204	296	52	group	group	NN
cord-272051-arz8r204	296	53	I	-PRON-	PRP
cord-272051-arz8r204	296	54	PAKs	paks	VBP
cord-272051-arz8r204	296	55	in	in	IN
cord-272051-arz8r204	296	56	HIV	HIV	NNP
cord-272051-arz8r204	296	57	infection	infection	NN
cord-272051-arz8r204	296	58	Cathepsin	Cathepsin	NNP
cord-272051-arz8r204	296	59	L	L	NNP
cord-272051-arz8r204	296	60	is	be	VBZ
cord-272051-arz8r204	296	61	involved	involve	VBN
cord-272051-arz8r204	296	62	in	in	IN
cord-272051-arz8r204	296	63	proteolytic	proteolytic	JJ
cord-272051-arz8r204	296	64	processing	processing	NN
cord-272051-arz8r204	296	65	of	of	IN
cord-272051-arz8r204	296	66	the	the	DT
cord-272051-arz8r204	296	67	Hendra	Hendra	NNP
cord-272051-arz8r204	296	68	virus	virus	NN
cord-272051-arz8r204	296	69	fusion	fusion	NN
cord-272051-arz8r204	296	70	protein	protein	NN
cord-272051-arz8r204	297	1	The	the	DT
cord-272051-arz8r204	297	2	human	human	JJ
cord-272051-arz8r204	297	3	immunodeficiency	immunodeficiency	NN
cord-272051-arz8r204	297	4	virus	virus	NN
cord-272051-arz8r204	298	1	(	(	-LRB-
cord-272051-arz8r204	298	2	HIV)-1	hiv)-1	JJ
cord-272051-arz8r204	298	3	protease	protease	NN
cord-272051-arz8r204	298	4	inhibitor	inhibitor	NN
cord-272051-arz8r204	298	5	saquinavir	saquinavir	NNS
cord-272051-arz8r204	298	6	inhibits	inhibit	VBZ
cord-272051-arz8r204	298	7	proteasome	proteasome	JJ
cord-272051-arz8r204	298	8	function	function	NN
cord-272051-arz8r204	298	9	and	and	CC
cord-272051-arz8r204	298	10	causes	cause	VBZ
cord-272051-arz8r204	298	11	apoptosis	apoptosis	NN
cord-272051-arz8r204	298	12	and	and	CC
cord-272051-arz8r204	298	13	radiosensitization	radiosensitization	NN
cord-272051-arz8r204	298	14	in	in	IN
cord-272051-arz8r204	298	15	non	non	JJ
cord-272051-arz8r204	298	16	-	-	JJ
cord-272051-arz8r204	298	17	HIV	hiv	JJ
cord-272051-arz8r204	298	18	-	-	HYPH
cord-272051-arz8r204	298	19	associated	associate	VBN
cord-272051-arz8r204	298	20	human	human	JJ
cord-272051-arz8r204	298	21	cancer	cancer	NN
cord-272051-arz8r204	298	22	cells	cell	NNS
cord-272051-arz8r204	298	23	Genome	Genome	NNP
cord-272051-arz8r204	298	24	-	-	HYPH
cord-272051-arz8r204	298	25	wide	wide	JJ
cord-272051-arz8r204	298	26	analysis	analysis	NN
cord-272051-arz8r204	298	27	of	of	IN
cord-272051-arz8r204	298	28	human	human	JJ
cord-272051-arz8r204	298	29	kinases	kinase	NNS
cord-272051-arz8r204	298	30	in	in	IN
cord-272051-arz8r204	298	31	clathrin	clathrin	NN
cord-272051-arz8r204	298	32	-	-	:
cord-272051-arz8r204	298	33	and	and	CC
cord-272051-arz8r204	298	34	caveolae	caveolae	NNP
cord-272051-arz8r204	298	35	/	/	SYM
cord-272051-arz8r204	298	36	raftmediated	raftmediate	VBN
cord-272051-arz8r204	298	37	endocytosis	endocytosis	NN
cord-272051-arz8r204	298	38	Synchronised	synchronised	JJ
cord-272051-arz8r204	298	39	transmembrane	transmembrane	NN
cord-272051-arz8r204	298	40	insertion	insertion	NN
cord-272051-arz8r204	298	41	and	and	CC
cord-272051-arz8r204	298	42	glycosylation	glycosylation	NN
cord-272051-arz8r204	298	43	of	of	IN
cord-272051-arz8r204	298	44	a	a	DT
cord-272051-arz8r204	298	45	nascent	nascent	JJ
cord-272051-arz8r204	298	46	membrane	membrane	NN
cord-272051-arz8r204	298	47	protein	protein	NN
cord-272051-arz8r204	298	48	Expanding	expand	VBG
cord-272051-arz8r204	298	49	the	the	DT
cord-272051-arz8r204	298	50	frontiers	frontier	NNS
cord-272051-arz8r204	298	51	of	of	IN
cord-272051-arz8r204	298	52	existing	exist	VBG
cord-272051-arz8r204	298	53	antiviral	antiviral	JJ
cord-272051-arz8r204	298	54	drugs	drug	NNS
cord-272051-arz8r204	298	55	:	:	:
cord-272051-arz8r204	298	56	possible	possible	JJ
cord-272051-arz8r204	298	57	effects	effect	NNS
cord-272051-arz8r204	298	58	of	of	IN
cord-272051-arz8r204	298	59	HIV-1	HIV-1	NNP
cord-272051-arz8r204	298	60	protease	protease	NN
cord-272051-arz8r204	298	61	inhibitors	inhibitor	NNS
cord-272051-arz8r204	298	62	against	against	IN
cord-272051-arz8r204	298	63	SARS	SARS	NNP
cord-272051-arz8r204	298	64	and	and	CC
cord-272051-arz8r204	298	65	avian	avian	JJ
cord-272051-arz8r204	298	66	influenza	influenza	NN
cord-272051-arz8r204	298	67	Role	role	NN
cord-272051-arz8r204	298	68	of	of	IN
cord-272051-arz8r204	298	69	endosomal	endosomal	NNP
cord-272051-arz8r204	298	70	cathepsins	cathepsin	NNS
cord-272051-arz8r204	298	71	in	in	IN
cord-272051-arz8r204	298	72	entry	entry	NN
cord-272051-arz8r204	298	73	mediated	mediate	VBN
cord-272051-arz8r204	298	74	by	by	IN
cord-272051-arz8r204	298	75	the	the	DT
cord-272051-arz8r204	298	76	Ebola	Ebola	NNP
cord-272051-arz8r204	298	77	virus	virus	NN
cord-272051-arz8r204	298	78	glycoprotein	glycoprotein	NN
cord-272051-arz8r204	299	1	HIV	HIV	NNP
cord-272051-arz8r204	299	2	protease	protease	NN
cord-272051-arz8r204	299	3	inhibitors	inhibitor	NNS
cord-272051-arz8r204	299	4	are	be	VBP
cord-272051-arz8r204	299	5	potent	potent	JJ
cord-272051-arz8r204	299	6	antiangiogenic	antiangiogenic	JJ
cord-272051-arz8r204	299	7	molecules	molecule	NNS
cord-272051-arz8r204	299	8	and	and	CC
cord-272051-arz8r204	299	9	promote	promote	VB
cord-272051-arz8r204	299	10	regression	regression	NN
cord-272051-arz8r204	299	11	of	of	IN
cord-272051-arz8r204	299	12	Kaposi	Kaposi	NNP
cord-272051-arz8r204	299	13	sarcoma	sarcoma	NN
cord-272051-arz8r204	299	14	Structured	Structured	NNP
cord-272051-arz8r204	299	15	model	model	NN
cord-272051-arz8r204	299	16	of	of	IN
cord-272051-arz8r204	299	17	influenza	influenza	NN
cord-272051-arz8r204	299	18	virus	virus	NN
cord-272051-arz8r204	299	19	replication	replication	NN
cord-272051-arz8r204	299	20	in	in	IN
cord-272051-arz8r204	299	21	MDCK	MDCK	NNP
cord-272051-arz8r204	299	22	cells	cell	NNS
cord-272051-arz8r204	300	1	In	in	IN
cord-272051-arz8r204	300	2	vitro	vitro	FW
cord-272051-arz8r204	300	3	antiviral	antiviral	JJ
cord-272051-arz8r204	300	4	activity	activity	NN
cord-272051-arz8r204	300	5	of	of	IN
cord-272051-arz8r204	300	6	favipiravir	favipiravir	NNS
cord-272051-arz8r204	300	7	(	(	-LRB-
cord-272051-arz8r204	300	8	T-705	t-705	NN
cord-272051-arz8r204	300	9	)	)	-RRB-
cord-272051-arz8r204	300	10	against	against	IN
cord-272051-arz8r204	300	11	drug	drug	NN
cord-272051-arz8r204	300	12	-	-	HYPH
cord-272051-arz8r204	300	13	resistant	resistant	JJ
cord-272051-arz8r204	300	14	influenza	influenza	NN
cord-272051-arz8r204	300	15	and	and	CC
cord-272051-arz8r204	300	16	2009	2009	CD
cord-272051-arz8r204	300	17	A(H1N1	A(H1N1	NNP
cord-272051-arz8r204	300	18	)	)	-RRB-
cord-272051-arz8r204	300	19	viruses	virus	NNS
cord-272051-arz8r204	300	20	Modeling	model	VBG
cord-272051-arz8r204	300	21	the	the	DT
cord-272051-arz8r204	300	22	viral	viral	JJ
cord-272051-arz8r204	300	23	dynamics	dynamic	NNS
cord-272051-arz8r204	300	24	of	of	IN
cord-272051-arz8r204	300	25	influenza	influenza	NN
cord-272051-arz8r204	300	26	A	a	DT
cord-272051-arz8r204	300	27	virus	virus	NN
cord-272051-arz8r204	300	28	infection	infection	NN
cord-272051-arz8r204	300	29	Generation	generation	NN
cord-272051-arz8r204	300	30	of	of	IN
cord-272051-arz8r204	300	31	a	a	DT
cord-272051-arz8r204	300	32	flexible	flexible	JJ
cord-272051-arz8r204	300	33	cell	cell	NN
cord-272051-arz8r204	300	34	line	line	NN
cord-272051-arz8r204	300	35	with	with	IN
cord-272051-arz8r204	300	36	regulatable	regulatable	JJ
cord-272051-arz8r204	300	37	,	,	,
cord-272051-arz8r204	300	38	high	high	JJ
cord-272051-arz8r204	300	39	-	-	HYPH
cord-272051-arz8r204	300	40	level	level	NN
cord-272051-arz8r204	300	41	expression	expression	NN
cord-272051-arz8r204	300	42	of	of	IN
cord-272051-arz8r204	300	43	HIV	HIV	NNP
cord-272051-arz8r204	300	44	Gag	Gag	NNP
cord-272051-arz8r204	300	45	/	/	SYM
cord-272051-arz8r204	300	46	Pol	Pol	NNP
cord-272051-arz8r204	300	47	particles	particle	NNS
cord-272051-arz8r204	300	48	capable	capable	JJ
cord-272051-arz8r204	300	49	of	of	IN
cord-272051-arz8r204	300	50	packaging	package	VBG
cord-272051-arz8r204	300	51	HIV	HIV	NNP
cord-272051-arz8r204	300	52	-	-	HYPH
cord-272051-arz8r204	300	53	derived	derive	VBN
cord-272051-arz8r204	300	54	vectors	vector	NNS
cord-272051-arz8r204	300	55	Effects	effect	NNS
cord-272051-arz8r204	300	56	of	of	IN
cord-272051-arz8r204	300	57	HIV	HIV	NNP
cord-272051-arz8r204	300	58	protease	protease	NN
cord-272051-arz8r204	300	59	inhibitor	inhibitor	NN
cord-272051-arz8r204	300	60	ritonavir	ritonavir	NNS
cord-272051-arz8r204	300	61	on	on	IN
cord-272051-arz8r204	300	62	Akt	Akt	NNP
cord-272051-arz8r204	300	63	-	-	HYPH
cord-272051-arz8r204	300	64	regulated	regulate	VBN
cord-272051-arz8r204	300	65	cell	cell	NN
cord-272051-arz8r204	300	66	proliferation	proliferation	NN
cord-272051-arz8r204	300	67	in	in	IN
cord-272051-arz8r204	300	68	breast	breast	NN
cord-272051-arz8r204	300	69	cancer	cancer	NN
cord-272051-arz8r204	300	70	Role	role	NN
cord-272051-arz8r204	300	71	of	of	IN
cord-272051-arz8r204	300	72	hemagglutinin	hemagglutinin	NN
cord-272051-arz8r204	300	73	cleavage	cleavage	NN
cord-272051-arz8r204	300	74	for	for	IN
cord-272051-arz8r204	300	75	the	the	DT
cord-272051-arz8r204	300	76	pathogenicity	pathogenicity	NN
cord-272051-arz8r204	300	77	of	of	IN
cord-272051-arz8r204	300	78	influenza	influenza	NN
cord-272051-arz8r204	300	79	virus	virus	NN
cord-272051-arz8r204	300	80	Biochemistry	Biochemistry	NNP
cord-272051-arz8r204	300	81	.	.	.
cord-272051-arz8r204	301	1	Viral	viral	JJ
cord-272051-arz8r204	301	2	glycoproteins	glycoprotein	NNS
cord-272051-arz8r204	301	3	and	and	CC
cord-272051-arz8r204	301	4	an	an	DT
cord-272051-arz8r204	301	5	evolutionary	evolutionary	JJ
cord-272051-arz8r204	301	6	conundrum	conundrum	NN
cord-272051-arz8r204	301	7	Novel	Novel	NNP
cord-272051-arz8r204	301	8	pandemic	pandemic	NN
cord-272051-arz8r204	301	9	influenza	influenza	NN
cord-272051-arz8r204	301	10	A(H1N1	a(h1n1	NN
cord-272051-arz8r204	301	11	)	)	-RRB-
cord-272051-arz8r204	302	1	viruses	virus	NNS
cord-272051-arz8r204	302	2	are	be	VBP
cord-272051-arz8r204	302	3	potently	potently	RB
cord-272051-arz8r204	302	4	inhibited	inhibit	VBN
cord-272051-arz8r204	302	5	by	by	IN
cord-272051-arz8r204	302	6	DAS181	DAS181	NNP
cord-272051-arz8r204	302	7	,	,	,
cord-272051-arz8r204	302	8	a	a	DT
cord-272051-arz8r204	302	9	sialidase	sialidase	NN
cord-272051-arz8r204	302	10	fusion	fusion	NN
cord-272051-arz8r204	302	11	protein	protein	NN
cord-272051-arz8r204	302	12	Transcription	transcription	NN
cord-272051-arz8r204	302	13	and	and	CC
cord-272051-arz8r204	302	14	replication	replication	NN
cord-272051-arz8r204	302	15	of	of	IN
cord-272051-arz8r204	302	16	nonsegmented	nonsegmente	VBN
cord-272051-arz8r204	302	17	negative	negative	JJ
cord-272051-arz8r204	302	18	-	-	HYPH
cord-272051-arz8r204	302	19	strand	strand	NN
cord-272051-arz8r204	302	20	RNA	RNA	NNP
cord-272051-arz8r204	302	21	viruses	virus	NNS
cord-272051-arz8r204	303	1	HIV	HIV	NNP
cord-272051-arz8r204	303	2	protease	protease	NN
cord-272051-arz8r204	303	3	inhibitor	inhibitor	NN
cord-272051-arz8r204	303	4	nelfinavir	nelfinavir	NNP
cord-272051-arz8r204	303	5	inhibits	inhibit	VBZ
cord-272051-arz8r204	303	6	replication	replication	NN
cord-272051-arz8r204	303	7	of	of	IN
cord-272051-arz8r204	303	8	SARS	SARS	NNP
cord-272051-arz8r204	303	9	-	-	HYPH
cord-272051-arz8r204	303	10	associated	associate	VBN
cord-272051-arz8r204	303	11	coronavirus	coronavirus	NN
cord-272051-arz8r204	304	1	This	this	DT
cord-272051-arz8r204	304	2	work	work	NN
cord-272051-arz8r204	304	3	was	be	VBD
cord-272051-arz8r204	304	4	supported	support	VBN
cord-272051-arz8r204	304	5	by	by	IN
cord-272051-arz8r204	304	6	grants	grant	NNS
cord-272051-arz8r204	304	7	from	from	IN
cord-272051-arz8r204	304	8	the	the	DT
cord-272051-arz8r204	304	9	AIDS	AIDS	NNP
cord-272051-arz8r204	304	10	project	project	NN
cord-272051-arz8r204	304	11	of	of	IN
cord-272051-arz8r204	304	12	the	the	DT
cord-272051-arz8r204	304	13	Ministry	Ministry	NNP
cord-272051-arz8r204	304	14	of	of	IN
cord-272051-arz8r204	304	15	Health	Health	NNP
cord-272051-arz8r204	304	16	,	,	,
cord-272051-arz8r204	304	17	Rome	Rome	NNP
cord-272051-arz8r204	304	18	,	,	,
cord-272051-arz8r204	304	19	Italy	Italy	NNP
cord-272051-arz8r204	304	20	.	.	.
cord-272051-arz8r204	305	1	T-20	T-20	NNP
cord-272051-arz8r204	305	2	and	and	CC
cord-272051-arz8r204	305	3	PIs	pi	NNS
cord-272051-arz8r204	305	4	were	be	VBD
cord-272051-arz8r204	305	5	obtained	obtain	VBN
cord-272051-arz8r204	305	6	from	from	IN
cord-272051-arz8r204	305	7	the	the	DT
cord-272051-arz8r204	305	8	NIH	NIH	NNP
cord-272051-arz8r204	305	9	AIDS	AIDS	NNP
cord-272051-arz8r204	305	10	Research	Research	NNP
cord-272051-arz8r204	305	11	and	and	CC
cord-272051-arz8r204	305	12	Reference	Reference	NNP
cord-272051-arz8r204	305	13	Program	Program	NNP
cord-272051-arz8r204	305	14	.	.	.
cord-272051-arz8r204	306	1	I	-PRON-	PRP
cord-272051-arz8r204	306	2	thank	thank	VBP
cord-272051-arz8r204	306	3	P.	P.	NNP
cord-272051-arz8r204	306	4	Borghi	Borghi	NNP
cord-272051-arz8r204	306	5	,	,	,
cord-272051-arz8r204	306	6	Department	Department	NNP
cord-272051-arz8r204	306	7	of	of	IN
cord-272051-arz8r204	306	8	Cellular	Cellular	NNP
cord-272051-arz8r204	306	9	Biology	Biology	NNP
cord-272051-arz8r204	306	10	and	and	CC
cord-272051-arz8r204	306	11	Neuroscience	Neuroscience	NNP
cord-272051-arz8r204	306	12	,	,	,
cord-272051-arz8r204	306	13	Istituto	Istituto	NNP
cord-272051-arz8r204	306	14	Superiore	Superiore	NNP
cord-272051-arz8r204	307	1	di	di	NNP
cord-272051-arz8r204	307	2	Sanità	Sanità	NNP
cord-272051-arz8r204	307	3	,	,	,
cord-272051-arz8r204	307	4	Rome	Rome	NNP
cord-272051-arz8r204	307	5	,	,	,
cord-272051-arz8r204	307	6	Italy	Italy	NNP
cord-272051-arz8r204	307	7	for	for	IN
cord-272051-arz8r204	307	8	kindly	kindly	RB
cord-272051-arz8r204	307	9	supplying	supply	VBG
cord-272051-arz8r204	307	10	both	both	CC
cord-272051-arz8r204	307	11	VSV	VSV	NNP
cord-272051-arz8r204	307	12	and	and	CC
cord-272051-arz8r204	307	13	NDV	NDV	NNP
cord-272051-arz8r204	307	14	preparations	preparation	NNS
cord-272051-arz8r204	307	15	.	.	.
cord-272051-arz8r204	308	1	I	-PRON-	PRP
cord-272051-arz8r204	308	2	also	also	RB
cord-272051-arz8r204	308	3	thank	thank	VBP
cord-272051-arz8r204	308	4	A.R.	A.R.	NNP
cord-272051-arz8r204	308	5	Castrucci	Castrucci	NNP
cord-272051-arz8r204	308	6	and	and	CC
cord-272051-arz8r204	308	7	A.M.	A.M.	NNP
cord-272051-arz8r204	308	8	Ciccaglione	Ciccaglione	NNP
cord-272051-arz8r204	308	9	,	,	,
cord-272051-arz8r204	308	10	Department	Department	NNP
cord-272051-arz8r204	308	11	of	of	IN
cord-272051-arz8r204	308	12	Infectious	Infectious	NNP
cord-272051-arz8r204	308	13	,	,	,
cord-272051-arz8r204	308	14	Parasitic	parasitic	JJ
cord-272051-arz8r204	308	15	and	and	CC
cord-272051-arz8r204	308	16	Immunomediated	Immunomediated	NNP
cord-272051-arz8r204	308	17	Diseases	Diseases	NNPS
cord-272051-arz8r204	308	18	,	,	,
cord-272051-arz8r204	308	19	Istituto	Istituto	NNP
cord-272051-arz8r204	308	20	Superiore	Superiore	NNP
cord-272051-arz8r204	308	21	di	di	FW
cord-272051-arz8r204	308	22	Sanità	Sanità	NNP
cord-272051-arz8r204	308	23	,	,	,
cord-272051-arz8r204	308	24	Rome	Rome	NNP
cord-272051-arz8r204	308	25	,	,	,
cord-272051-arz8r204	308	26	Italy	Italy	NNP
cord-272051-arz8r204	308	27	,	,	,
cord-272051-arz8r204	308	28	for	for	IN
cord-272051-arz8r204	308	29	kindly	kindly	RB
cord-272051-arz8r204	308	30	providing	provide	VBG
cord-272051-arz8r204	308	31	influenza	influenza	NN
cord-272051-arz8r204	308	32	virus	virus	NN
cord-272051-arz8r204	308	33	preparations	preparation	NNS
cord-272051-arz8r204	308	34	and	and	CC
cord-272051-arz8r204	308	35	the	the	DT
cord-272051-arz8r204	308	36	vector	vector	NN
cord-272051-arz8r204	308	37	expressing	express	VBG
cord-272051-arz8r204	308	38	fd	fd	NNP
cord-272051-arz8r204	308	39	VSV	VSV	NNP
cord-272051-arz8r204	308	40	-	-	HYPH
cord-272051-arz8r204	308	41	G	G	NNP
cord-272051-arz8r204	308	42	,	,	,
cord-272051-arz8r204	308	43	respectively	respectively	RB
cord-272051-arz8r204	308	44	.	.	.
cord-272051-arz8r204	309	1	I	-PRON-	PRP
cord-272051-arz8r204	309	2	'm	be	VBP
cord-272051-arz8r204	309	3	indebted	indebted	JJ
cord-272051-arz8r204	309	4	to	to	IN
cord-272051-arz8r204	309	5	G.	G.	NNP
cord-272051-arz8r204	309	6	Fornari	Fornari	NNP
cord-272051-arz8r204	309	7	Luswergh	Luswergh	NNP
cord-272051-arz8r204	309	8	for	for	IN
cord-272051-arz8r204	309	9	her	-PRON-	PRP$
cord-272051-arz8r204	309	10	excellent	excellent	JJ
cord-272051-arz8r204	309	11	editorial	editorial	JJ
cord-272051-arz8r204	309	12	assistance	assistance	NN
cord-272051-arz8r204	309	13	.	.	.