id	sid	tid	token	lemma	pos
cord-289152-w5ynbewh	1	1	key	key	JJ
cord-289152-w5ynbewh	2	1	:	:	:
cord-289152-w5ynbewh	2	2	cord-289152-w5ynbewh	cord-289152-w5ynbewh	JJ
cord-289152-w5ynbewh	2	3	authors	author	NNS
cord-289152-w5ynbewh	2	4	:	:	:
cord-289152-w5ynbewh	2	5	Lee	Lee	NNP
cord-289152-w5ynbewh	2	6	,	,	,
cord-289152-w5ynbewh	2	7	Sang	Sang	NNP
cord-289152-w5ynbewh	2	8	-	-	HYPH
cord-289152-w5ynbewh	2	9	Myeong	Myeong	NNP
cord-289152-w5ynbewh	2	10	;	;	:
cord-289152-w5ynbewh	2	11	Kleiboeker	Kleiboeker	NNP
cord-289152-w5ynbewh	2	12	,	,	,
cord-289152-w5ynbewh	2	13	Steven	Steven	NNP
cord-289152-w5ynbewh	2	14	B.	B.	NNP
cord-289152-w5ynbewh	2	15	title	title	NN
cord-289152-w5ynbewh	2	16	:	:	:
cord-289152-w5ynbewh	3	1	Porcine	porcine	JJ
cord-289152-w5ynbewh	3	2	arterivirus	arterivirus	NN
cord-289152-w5ynbewh	3	3	activates	activate	VBZ
cord-289152-w5ynbewh	3	4	the	the	DT
cord-289152-w5ynbewh	3	5	NF	nf	NN
cord-289152-w5ynbewh	3	6	-	-	HYPH
cord-289152-w5ynbewh	3	7	κB	κB	NNP
cord-289152-w5ynbewh	3	8	pathway	pathway	NN
cord-289152-w5ynbewh	3	9	through	through	IN
cord-289152-w5ynbewh	3	10	IκB	iκb	JJ
cord-289152-w5ynbewh	3	11	degradation	degradation	NN
cord-289152-w5ynbewh	3	12	date	date	NN
cord-289152-w5ynbewh	4	1	:	:	:
cord-289152-w5ynbewh	4	2	2005	2005	CD
cord-289152-w5ynbewh	4	3	-	-	SYM
cord-289152-w5ynbewh	4	4	11	11	CD
cord-289152-w5ynbewh	4	5	-	-	SYM
cord-289152-w5ynbewh	4	6	10	10	CD
cord-289152-w5ynbewh	4	7	journal	journal	NN
cord-289152-w5ynbewh	4	8	:	:	:
cord-289152-w5ynbewh	5	1	Virology	virology	NN
cord-289152-w5ynbewh	5	2	DOI	DOI	NNP
cord-289152-w5ynbewh	5	3	:	:	:
cord-289152-w5ynbewh	6	1	10.1016/	10.1016/	CD
cord-289152-w5ynbewh	7	1	j.virol.2005.07.034	j.virol.2005.07.034	NNP
cord-289152-w5ynbewh	7	2	sha	sha	XX
cord-289152-w5ynbewh	7	3	:	:	:
cord-289152-w5ynbewh	8	1	89e162115392f120533361ea7ed71657dfb6e05e	89e162115392f120533361ea7ed71657dfb6e05e	CD
cord-289152-w5ynbewh	8	2	doc_id	doc_id	CD
cord-289152-w5ynbewh	8	3	:	:	:
cord-289152-w5ynbewh	9	1	289152	289152	CD
cord-289152-w5ynbewh	9	2	cord_uid	cord_uid	NNS
cord-289152-w5ynbewh	9	3	:	:	:
cord-289152-w5ynbewh	10	1	w5ynbewh	w5ynbewh	NNP
cord-289152-w5ynbewh	10	2	Nuclear	nuclear	JJ
cord-289152-w5ynbewh	10	3	factor	factor	NN
cord-289152-w5ynbewh	10	4	-	-	:
cord-289152-w5ynbewh	10	5	kappaB	kappaB	NNP
cord-289152-w5ynbewh	10	6	(	(	-LRB-
cord-289152-w5ynbewh	10	7	NF	nf	NN
cord-289152-w5ynbewh	10	8	-	-	HYPH
cord-289152-w5ynbewh	10	9	κB	κB	NNP
cord-289152-w5ynbewh	10	10	)	)	-RRB-
cord-289152-w5ynbewh	10	11	is	be	VBZ
cord-289152-w5ynbewh	10	12	a	a	DT
cord-289152-w5ynbewh	10	13	critical	critical	JJ
cord-289152-w5ynbewh	10	14	regulator	regulator	NN
cord-289152-w5ynbewh	10	15	of	of	IN
cord-289152-w5ynbewh	10	16	innate	innate	JJ
cord-289152-w5ynbewh	10	17	and	and	CC
cord-289152-w5ynbewh	10	18	adaptive	adaptive	JJ
cord-289152-w5ynbewh	10	19	immune	immune	JJ
cord-289152-w5ynbewh	10	20	function	function	NN
cord-289152-w5ynbewh	10	21	as	as	RB
cord-289152-w5ynbewh	10	22	well	well	RB
cord-289152-w5ynbewh	10	23	as	as	IN
cord-289152-w5ynbewh	10	24	cell	cell	NN
cord-289152-w5ynbewh	10	25	proliferation	proliferation	NN
cord-289152-w5ynbewh	10	26	and	and	CC
cord-289152-w5ynbewh	10	27	survival	survival	NN
cord-289152-w5ynbewh	10	28	.	.	.
cord-289152-w5ynbewh	11	1	The	the	DT
cord-289152-w5ynbewh	11	2	present	present	JJ
cord-289152-w5ynbewh	11	3	study	study	NN
cord-289152-w5ynbewh	11	4	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	11	5	for	for	IN
cord-289152-w5ynbewh	11	6	the	the	DT
cord-289152-w5ynbewh	11	7	first	first	JJ
cord-289152-w5ynbewh	11	8	time	time	NN
cord-289152-w5ynbewh	11	9	that	that	IN
cord-289152-w5ynbewh	11	10	a	a	DT
cord-289152-w5ynbewh	11	11	virus	virus	NN
cord-289152-w5ynbewh	11	12	belonging	belong	VBG
cord-289152-w5ynbewh	11	13	to	to	IN
cord-289152-w5ynbewh	11	14	the	the	DT
cord-289152-w5ynbewh	11	15	Arteriviridae	Arteriviridae	NNP
cord-289152-w5ynbewh	11	16	family	family	NN
cord-289152-w5ynbewh	11	17	activates	activate	VBZ
cord-289152-w5ynbewh	11	18	NF	NF	NNP
cord-289152-w5ynbewh	11	19	-	-	HYPH
cord-289152-w5ynbewh	11	20	κB	κB	NNP
cord-289152-w5ynbewh	11	21	in	in	IN
cord-289152-w5ynbewh	11	22	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	11	23	cells	cell	NNS
cord-289152-w5ynbewh	11	24	and	and	CC
cord-289152-w5ynbewh	11	25	alveolar	alveolar	JJ
cord-289152-w5ynbewh	11	26	macrophages	macrophage	NNS
cord-289152-w5ynbewh	11	27	.	.	.
cord-289152-w5ynbewh	12	1	In	in	IN
cord-289152-w5ynbewh	12	2	porcine	porcine	JJ
cord-289152-w5ynbewh	12	3	reproductive	reproductive	JJ
cord-289152-w5ynbewh	12	4	and	and	CC
cord-289152-w5ynbewh	12	5	respiratory	respiratory	JJ
cord-289152-w5ynbewh	12	6	syndrome	syndrome	NN
cord-289152-w5ynbewh	12	7	virus	virus	NN
cord-289152-w5ynbewh	12	8	(	(	-LRB-
cord-289152-w5ynbewh	12	9	PRRSV)-infected	prrsv)-infected	JJ
cord-289152-w5ynbewh	12	10	cells	cell	NNS
cord-289152-w5ynbewh	12	11	,	,	,
cord-289152-w5ynbewh	13	1	NF	NF	NNP
cord-289152-w5ynbewh	13	2	-	-	HYPH
cord-289152-w5ynbewh	13	3	κB	κb	CD
cord-289152-w5ynbewh	13	4	activation	activation	NN
cord-289152-w5ynbewh	13	5	was	be	VBD
cord-289152-w5ynbewh	13	6	characterized	characterize	VBN
cord-289152-w5ynbewh	13	7	by	by	IN
cord-289152-w5ynbewh	13	8	translocation	translocation	NN
cord-289152-w5ynbewh	13	9	of	of	IN
cord-289152-w5ynbewh	13	10	NF	nf	NN
cord-289152-w5ynbewh	13	11	-	-	HYPH
cord-289152-w5ynbewh	13	12	κB	κB	NNP
cord-289152-w5ynbewh	13	13	from	from	IN
cord-289152-w5ynbewh	13	14	the	the	DT
cord-289152-w5ynbewh	13	15	cytoplasm	cytoplasm	NN
cord-289152-w5ynbewh	13	16	to	to	IN
cord-289152-w5ynbewh	13	17	the	the	DT
cord-289152-w5ynbewh	13	18	nucleus	nucleus	NN
cord-289152-w5ynbewh	13	19	,	,	,
cord-289152-w5ynbewh	13	20	increased	increase	VBN
cord-289152-w5ynbewh	13	21	DNA	dna	NN
cord-289152-w5ynbewh	13	22	binding	binding	NN
cord-289152-w5ynbewh	13	23	activity	activity	NN
cord-289152-w5ynbewh	13	24	,	,	,
cord-289152-w5ynbewh	13	25	and	and	CC
cord-289152-w5ynbewh	13	26	NF	nf	NN
cord-289152-w5ynbewh	13	27	-	-	HYPH
cord-289152-w5ynbewh	13	28	κB	κB	NNP
cord-289152-w5ynbewh	13	29	-	-	HYPH
cord-289152-w5ynbewh	13	30	regulated	regulate	VBN
cord-289152-w5ynbewh	13	31	gene	gene	NN
cord-289152-w5ynbewh	13	32	expression	expression	NN
cord-289152-w5ynbewh	13	33	.	.	.
cord-289152-w5ynbewh	14	1	NF	NF	NNP
cord-289152-w5ynbewh	14	2	-	-	HYPH
cord-289152-w5ynbewh	14	3	κB	κb	CD
cord-289152-w5ynbewh	14	4	activation	activation	NN
cord-289152-w5ynbewh	14	5	was	be	VBD
cord-289152-w5ynbewh	14	6	increased	increase	VBN
cord-289152-w5ynbewh	14	7	as	as	IN
cord-289152-w5ynbewh	14	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	14	9	infection	infection	NN
cord-289152-w5ynbewh	14	10	progressed	progress	VBD
cord-289152-w5ynbewh	14	11	and	and	CC
cord-289152-w5ynbewh	14	12	in	in	IN
cord-289152-w5ynbewh	14	13	a	a	DT
cord-289152-w5ynbewh	14	14	viral	viral	JJ
cord-289152-w5ynbewh	14	15	dose	dose	NN
cord-289152-w5ynbewh	14	16	-	-	HYPH
cord-289152-w5ynbewh	14	17	dependent	dependent	JJ
cord-289152-w5ynbewh	14	18	manner	manner	NN
cord-289152-w5ynbewh	14	19	.	.	.
cord-289152-w5ynbewh	15	1	UV	uv	NN
cord-289152-w5ynbewh	15	2	-	-	HYPH
cord-289152-w5ynbewh	15	3	inactivation	inactivation	NN
cord-289152-w5ynbewh	15	4	of	of	IN
cord-289152-w5ynbewh	15	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	15	6	significantly	significantly	RB
cord-289152-w5ynbewh	15	7	reduced	reduce	VBD
cord-289152-w5ynbewh	15	8	the	the	DT
cord-289152-w5ynbewh	15	9	level	level	NN
cord-289152-w5ynbewh	15	10	of	of	IN
cord-289152-w5ynbewh	15	11	NF	nf	NN
cord-289152-w5ynbewh	15	12	-	-	HYPH
cord-289152-w5ynbewh	15	13	κB	κb	CD
cord-289152-w5ynbewh	15	14	activation	activation	NN
cord-289152-w5ynbewh	15	15	.	.	.
cord-289152-w5ynbewh	16	1	Degradation	degradation	NN
cord-289152-w5ynbewh	16	2	of	of	IN
cord-289152-w5ynbewh	16	3	IκB	iκb	NN
cord-289152-w5ynbewh	16	4	protein	protein	NN
cord-289152-w5ynbewh	16	5	was	be	VBD
cord-289152-w5ynbewh	16	6	detected	detect	VBN
cord-289152-w5ynbewh	16	7	late	late	RB
cord-289152-w5ynbewh	16	8	in	in	IN
cord-289152-w5ynbewh	16	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	16	10	infection	infection	NN
cord-289152-w5ynbewh	16	11	,	,	,
cord-289152-w5ynbewh	16	12	and	and	CC
cord-289152-w5ynbewh	16	13	overexpression	overexpression	NN
cord-289152-w5ynbewh	16	14	of	of	IN
cord-289152-w5ynbewh	16	15	the	the	DT
cord-289152-w5ynbewh	16	16	dominant	dominant	JJ
cord-289152-w5ynbewh	16	17	negative	negative	JJ
cord-289152-w5ynbewh	16	18	form	form	NN
cord-289152-w5ynbewh	16	19	of	of	IN
cord-289152-w5ynbewh	16	20	IκBα	IκBα	NNP
cord-289152-w5ynbewh	16	21	(	(	-LRB-
cord-289152-w5ynbewh	16	22	IκBαDN	IκBαDN	NNP
cord-289152-w5ynbewh	16	23	)	)	-RRB-
cord-289152-w5ynbewh	16	24	significantly	significantly	RB
cord-289152-w5ynbewh	16	25	suppressed	suppress	VBD
cord-289152-w5ynbewh	16	26	NF	nf	NN
cord-289152-w5ynbewh	16	27	-	-	HYPH
cord-289152-w5ynbewh	16	28	κB	κb	CD
cord-289152-w5ynbewh	16	29	activation	activation	NN
cord-289152-w5ynbewh	16	30	induced	induce	VBN
cord-289152-w5ynbewh	16	31	by	by	IN
cord-289152-w5ynbewh	16	32	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	16	33	.	.	.
cord-289152-w5ynbewh	17	1	However	however	RB
cord-289152-w5ynbewh	17	2	,	,	,
cord-289152-w5ynbewh	17	3	IκBαDN	IκBαDN	NNP
cord-289152-w5ynbewh	17	4	did	do	VBD
cord-289152-w5ynbewh	17	5	not	not	RB
cord-289152-w5ynbewh	17	6	affect	affect	VB
cord-289152-w5ynbewh	17	7	viral	viral	JJ
cord-289152-w5ynbewh	17	8	replication	replication	NN
cord-289152-w5ynbewh	17	9	and	and	CC
cord-289152-w5ynbewh	17	10	viral	viral	JJ
cord-289152-w5ynbewh	17	11	cytopathic	cytopathic	JJ
cord-289152-w5ynbewh	17	12	effect	effect	NN
cord-289152-w5ynbewh	17	13	.	.	.
cord-289152-w5ynbewh	18	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	18	2	infection	infection	NN
cord-289152-w5ynbewh	18	3	induced	induce	VBD
cord-289152-w5ynbewh	18	4	oxidative	oxidative	JJ
cord-289152-w5ynbewh	18	5	stress	stress	NN
cord-289152-w5ynbewh	18	6	in	in	IN
cord-289152-w5ynbewh	18	7	cells	cell	NNS
cord-289152-w5ynbewh	18	8	by	by	IN
cord-289152-w5ynbewh	18	9	generating	generate	VBG
cord-289152-w5ynbewh	18	10	reactive	reactive	JJ
cord-289152-w5ynbewh	18	11	oxygen	oxygen	NN
cord-289152-w5ynbewh	18	12	species	specie	NNS
cord-289152-w5ynbewh	18	13	(	(	-LRB-
cord-289152-w5ynbewh	18	14	ROS	ROS	NNP
cord-289152-w5ynbewh	18	15	)	)	-RRB-
cord-289152-w5ynbewh	18	16	,	,	,
cord-289152-w5ynbewh	18	17	and	and	CC
cord-289152-w5ynbewh	18	18	antioxidants	antioxidant	NNS
cord-289152-w5ynbewh	18	19	inhibited	inhibit	VBN
cord-289152-w5ynbewh	18	20	NF	nf	NN
cord-289152-w5ynbewh	18	21	-	-	HYPH
cord-289152-w5ynbewh	18	22	κB	κb	CD
cord-289152-w5ynbewh	18	23	DNA	dna	NN
cord-289152-w5ynbewh	18	24	binding	binding	NN
cord-289152-w5ynbewh	18	25	activity	activity	NN
cord-289152-w5ynbewh	18	26	in	in	IN
cord-289152-w5ynbewh	18	27	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	18	28	-	-	HYPH
cord-289152-w5ynbewh	18	29	infected	infect	VBN
cord-289152-w5ynbewh	18	30	cells	cell	NNS
cord-289152-w5ynbewh	18	31	,	,	,
cord-289152-w5ynbewh	18	32	suggesting	suggest	VBG
cord-289152-w5ynbewh	18	33	ROS	ROS	NNP
cord-289152-w5ynbewh	18	34	as	as	IN
cord-289152-w5ynbewh	18	35	a	a	DT
cord-289152-w5ynbewh	18	36	mechanism	mechanism	NN
cord-289152-w5ynbewh	18	37	by	by	IN
cord-289152-w5ynbewh	18	38	which	which	WDT
cord-289152-w5ynbewh	18	39	NF	NF	NNP
cord-289152-w5ynbewh	18	40	-	-	HYPH
cord-289152-w5ynbewh	18	41	κB	κB	NNP
cord-289152-w5ynbewh	18	42	was	be	VBD
cord-289152-w5ynbewh	18	43	activated	activate	VBN
cord-289152-w5ynbewh	18	44	by	by	IN
cord-289152-w5ynbewh	18	45	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	18	46	infection	infection	NN
cord-289152-w5ynbewh	18	47	.	.	.
cord-289152-w5ynbewh	19	1	Moreover	moreover	RB
cord-289152-w5ynbewh	19	2	,	,	,
cord-289152-w5ynbewh	19	3	NF	nf	NN
cord-289152-w5ynbewh	19	4	-	-	HYPH
cord-289152-w5ynbewh	19	5	κB	κB	NNP
cord-289152-w5ynbewh	19	6	-	-	HYPH
cord-289152-w5ynbewh	19	7	dependent	dependent	JJ
cord-289152-w5ynbewh	19	8	expression	expression	NN
cord-289152-w5ynbewh	19	9	of	of	IN
cord-289152-w5ynbewh	19	10	matrix	matrix	NN
cord-289152-w5ynbewh	19	11	metalloproteinase	metalloproteinase	NN
cord-289152-w5ynbewh	19	12	(	(	-LRB-
cord-289152-w5ynbewh	19	13	MMP)-2	MMP)-2	NNP
cord-289152-w5ynbewh	19	14	and	and	CC
cord-289152-w5ynbewh	19	15	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	19	16	was	be	VBD
cord-289152-w5ynbewh	19	17	observed	observe	VBN
cord-289152-w5ynbewh	19	18	in	in	IN
cord-289152-w5ynbewh	19	19	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	19	20	-	-	HYPH
cord-289152-w5ynbewh	19	21	infected	infect	VBN
cord-289152-w5ynbewh	19	22	cells	cell	NNS
cord-289152-w5ynbewh	19	23	,	,	,
cord-289152-w5ynbewh	19	24	an	an	DT
cord-289152-w5ynbewh	19	25	observation	observation	NN
cord-289152-w5ynbewh	19	26	which	which	WDT
cord-289152-w5ynbewh	19	27	implies	imply	VBZ
cord-289152-w5ynbewh	19	28	that	that	IN
cord-289152-w5ynbewh	19	29	NF	nf	NN
cord-289152-w5ynbewh	19	30	-	-	HYPH
cord-289152-w5ynbewh	19	31	κB	κb	CD
cord-289152-w5ynbewh	19	32	activation	activation	NN
cord-289152-w5ynbewh	19	33	is	be	VBZ
cord-289152-w5ynbewh	19	34	a	a	DT
cord-289152-w5ynbewh	19	35	biologically	biologically	RB
cord-289152-w5ynbewh	19	36	significant	significant	JJ
cord-289152-w5ynbewh	19	37	aspect	aspect	NN
cord-289152-w5ynbewh	19	38	of	of	IN
cord-289152-w5ynbewh	19	39	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	19	40	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	19	41	.	.	.
cord-289152-w5ynbewh	20	1	The	the	DT
cord-289152-w5ynbewh	20	2	results	result	NNS
cord-289152-w5ynbewh	20	3	presented	present	VBN
cord-289152-w5ynbewh	20	4	here	here	RB
cord-289152-w5ynbewh	20	5	provide	provide	VB
cord-289152-w5ynbewh	20	6	a	a	DT
cord-289152-w5ynbewh	20	7	basis	basis	NN
cord-289152-w5ynbewh	20	8	for	for	IN
cord-289152-w5ynbewh	20	9	understanding	understand	VBG
cord-289152-w5ynbewh	20	10	molecular	molecular	JJ
cord-289152-w5ynbewh	20	11	pathways	pathway	NNS
cord-289152-w5ynbewh	20	12	of	of	IN
cord-289152-w5ynbewh	20	13	pathology	pathology	NN
cord-289152-w5ynbewh	20	14	and	and	CC
cord-289152-w5ynbewh	20	15	immune	immune	JJ
cord-289152-w5ynbewh	20	16	evasion	evasion	NN
cord-289152-w5ynbewh	20	17	associated	associate	VBN
cord-289152-w5ynbewh	20	18	with	with	IN
cord-289152-w5ynbewh	20	19	disease	disease	NN
cord-289152-w5ynbewh	20	20	caused	cause	VBN
cord-289152-w5ynbewh	20	21	by	by	IN
cord-289152-w5ynbewh	20	22	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	20	23	.	.	.
cord-289152-w5ynbewh	21	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	21	2	is	be	VBZ
cord-289152-w5ynbewh	21	3	an	an	DT
cord-289152-w5ynbewh	21	4	enveloped	envelop	VBN
cord-289152-w5ynbewh	21	5	,	,	,
cord-289152-w5ynbewh	21	6	positive	positive	JJ
cord-289152-w5ynbewh	21	7	-	-	HYPH
cord-289152-w5ynbewh	21	8	stranded	strand	VBN
cord-289152-w5ynbewh	21	9	RNA	RNA	NNP
cord-289152-w5ynbewh	21	10	virus	virus	NN
cord-289152-w5ynbewh	21	11	that	that	WDT
cord-289152-w5ynbewh	21	12	is	be	VBZ
cord-289152-w5ynbewh	21	13	a	a	DT
cord-289152-w5ynbewh	21	14	member	member	NN
cord-289152-w5ynbewh	21	15	of	of	IN
cord-289152-w5ynbewh	21	16	the	the	DT
cord-289152-w5ynbewh	21	17	order	order	NN
cord-289152-w5ynbewh	21	18	Nidovirales	Nidovirales	NNP
cord-289152-w5ynbewh	21	19	,	,	,
cord-289152-w5ynbewh	21	20	family	family	NN
cord-289152-w5ynbewh	21	21	Arteriviridae	Arteriviridae	NNP
cord-289152-w5ynbewh	21	22	,	,	,
cord-289152-w5ynbewh	21	23	along	along	IN
cord-289152-w5ynbewh	21	24	with	with	IN
cord-289152-w5ynbewh	21	25	lactate	lactate	NN
cord-289152-w5ynbewh	21	26	dehydrogenase	dehydrogenase	NN
cord-289152-w5ynbewh	21	27	-	-	HYPH
cord-289152-w5ynbewh	21	28	elevating	elevate	VBG
cord-289152-w5ynbewh	21	29	virus	virus	NN
cord-289152-w5ynbewh	21	30	of	of	IN
cord-289152-w5ynbewh	21	31	mice	mouse	NNS
cord-289152-w5ynbewh	21	32	,	,	,
cord-289152-w5ynbewh	21	33	equine	equine	JJ
cord-289152-w5ynbewh	21	34	arteritis	arteritis	NN
cord-289152-w5ynbewh	21	35	virus	virus	NN
cord-289152-w5ynbewh	21	36	,	,	,
cord-289152-w5ynbewh	21	37	and	and	CC
cord-289152-w5ynbewh	21	38	simian	simian	JJ
cord-289152-w5ynbewh	21	39	hemorrhagic	hemorrhagic	JJ
cord-289152-w5ynbewh	21	40	fever	fever	NN
cord-289152-w5ynbewh	21	41	virus	virus	NN
cord-289152-w5ynbewh	21	42	.	.	.
cord-289152-w5ynbewh	22	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	22	2	causes	cause	VBZ
cord-289152-w5ynbewh	22	3	one	one	CD
cord-289152-w5ynbewh	22	4	of	of	IN
cord-289152-w5ynbewh	22	5	the	the	DT
cord-289152-w5ynbewh	22	6	most	most	RBS
cord-289152-w5ynbewh	22	7	economically	economically	RB
cord-289152-w5ynbewh	22	8	important	important	JJ
cord-289152-w5ynbewh	22	9	diseases	disease	NNS
cord-289152-w5ynbewh	22	10	of	of	IN
cord-289152-w5ynbewh	22	11	swine	swine	NN
cord-289152-w5ynbewh	22	12	which	which	WDT
cord-289152-w5ynbewh	22	13	is	be	VBZ
cord-289152-w5ynbewh	22	14	characterized	characterize	VBN
cord-289152-w5ynbewh	22	15	by	by	IN
cord-289152-w5ynbewh	22	16	severe	severe	JJ
cord-289152-w5ynbewh	22	17	and	and	CC
cord-289152-w5ynbewh	22	18	sometimes	sometimes	RB
cord-289152-w5ynbewh	22	19	fatal	fatal	JJ
cord-289152-w5ynbewh	22	20	respiratory	respiratory	JJ
cord-289152-w5ynbewh	22	21	disease	disease	NN
cord-289152-w5ynbewh	22	22	and	and	CC
cord-289152-w5ynbewh	22	23	reproductive	reproductive	JJ
cord-289152-w5ynbewh	22	24	failure	failure	NN
cord-289152-w5ynbewh	22	25	.	.	.
cord-289152-w5ynbewh	23	1	Infection	infection	NN
cord-289152-w5ynbewh	23	2	with	with	IN
cord-289152-w5ynbewh	23	3	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	23	4	also	also	RB
cord-289152-w5ynbewh	23	5	predisposes	predispose	VBZ
cord-289152-w5ynbewh	23	6	pigs	pig	NNS
cord-289152-w5ynbewh	23	7	to	to	IN
cord-289152-w5ynbewh	23	8	infection	infection	NN
cord-289152-w5ynbewh	23	9	by	by	IN
cord-289152-w5ynbewh	23	10	bacterial	bacterial	JJ
cord-289152-w5ynbewh	23	11	and	and	CC
cord-289152-w5ynbewh	23	12	viral	viral	JJ
cord-289152-w5ynbewh	23	13	pathogens	pathogen	NNS
cord-289152-w5ynbewh	23	14	such	such	JJ
cord-289152-w5ynbewh	23	15	as	as	IN
cord-289152-w5ynbewh	23	16	Steptococcus	Steptococcus	NNP
cord-289152-w5ynbewh	23	17	suis	suis	NN
cord-289152-w5ynbewh	23	18	,	,	,
cord-289152-w5ynbewh	23	19	Haemophilus	Haemophilus	NNP
cord-289152-w5ynbewh	23	20	parasuis	parasuis	NN
cord-289152-w5ynbewh	23	21	,	,	,
cord-289152-w5ynbewh	23	22	Mycoplasma	mycoplasma	NN
cord-289152-w5ynbewh	23	23	hyopneumoniae	hyopneumoniae	NN
cord-289152-w5ynbewh	23	24	,	,	,
cord-289152-w5ynbewh	23	25	Acti	Acti	NNP
cord-289152-w5ynbewh	23	26	-	-	HYPH
cord-289152-w5ynbewh	23	27	nobaccillus	nobaccillus	NNP
cord-289152-w5ynbewh	23	28	pleuropneumoniae	pleuropneumoniae	NN
cord-289152-w5ynbewh	23	29	,	,	,
cord-289152-w5ynbewh	23	30	Salmonella	Salmonella	NNP
cord-289152-w5ynbewh	23	31	spp	spp	NNS
cord-289152-w5ynbewh	23	32	.	.	.
cord-289152-w5ynbewh	24	1	,	,	,
cord-289152-w5ynbewh	24	2	and	and	CC
cord-289152-w5ynbewh	24	3	swine	swine	NN
cord-289152-w5ynbewh	24	4	influenza	influenza	NN
cord-289152-w5ynbewh	24	5	virus	virus	NN
cord-289152-w5ynbewh	24	6	(	(	-LRB-
cord-289152-w5ynbewh	24	7	Benfield	Benfield	NNP
cord-289152-w5ynbewh	24	8	et	et	NNP
cord-289152-w5ynbewh	24	9	al	al	NNP
cord-289152-w5ynbewh	24	10	.	.	NNP
cord-289152-w5ynbewh	24	11	,	,	,
cord-289152-w5ynbewh	24	12	1992	1992	CD
cord-289152-w5ynbewh	24	13	;	;	:
cord-289152-w5ynbewh	24	14	Done	do	VBN
cord-289152-w5ynbewh	24	15	and	and	CC
cord-289152-w5ynbewh	24	16	Paton	Paton	NNP
cord-289152-w5ynbewh	24	17	,	,	,
cord-289152-w5ynbewh	24	18	1995	1995	CD
cord-289152-w5ynbewh	24	19	;	;	:
cord-289152-w5ynbewh	24	20	Galina	Galina	NNP
cord-289152-w5ynbewh	24	21	et	et	NNP
cord-289152-w5ynbewh	24	22	al	al	NNP
cord-289152-w5ynbewh	24	23	.	.	NNP
cord-289152-w5ynbewh	24	24	,	,	,
cord-289152-w5ynbewh	24	25	1994	1994	CD
cord-289152-w5ynbewh	24	26	;	;	:
cord-289152-w5ynbewh	24	27	Groschup	Groschup	NNP
cord-289152-w5ynbewh	24	28	et	et	NNP
cord-289152-w5ynbewh	24	29	al	al	NNP
cord-289152-w5ynbewh	24	30	.	.	NNP
cord-289152-w5ynbewh	24	31	,	,	,
cord-289152-w5ynbewh	24	32	1993	1993	CD
cord-289152-w5ynbewh	24	33	;	;	:
cord-289152-w5ynbewh	24	34	Kawashima	Kawashima	NNP
cord-289152-w5ynbewh	24	35	et	et	NNP
cord-289152-w5ynbewh	24	36	al	al	NNP
cord-289152-w5ynbewh	24	37	.	.	NNP
cord-289152-w5ynbewh	24	38	,	,	,
cord-289152-w5ynbewh	24	39	1996	1996	CD
cord-289152-w5ynbewh	24	40	;	;	.
cord-289152-w5ynbewh	25	1	Zeman	Zeman	NNP
cord-289152-w5ynbewh	25	2	et	et	NNP
cord-289152-w5ynbewh	25	3	al	al	NNP
cord-289152-w5ynbewh	25	4	.	.	NNP
cord-289152-w5ynbewh	25	5	,	,	,
cord-289152-w5ynbewh	25	6	1993	1993	CD
cord-289152-w5ynbewh	25	7	)	)	-RRB-
cord-289152-w5ynbewh	25	8	.	.	.
cord-289152-w5ynbewh	26	1	The	the	DT
cord-289152-w5ynbewh	26	2	most	most	RBS
cord-289152-w5ynbewh	26	3	consistent	consistent	JJ
cord-289152-w5ynbewh	26	4	pathological	pathological	JJ
cord-289152-w5ynbewh	26	5	lesions	lesion	NNS
cord-289152-w5ynbewh	26	6	caused	cause	VBN
cord-289152-w5ynbewh	26	7	by	by	IN
cord-289152-w5ynbewh	26	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	26	9	during	during	IN
cord-289152-w5ynbewh	26	10	acute	acute	JJ
cord-289152-w5ynbewh	26	11	infection	infection	NN
cord-289152-w5ynbewh	26	12	are	be	VBP
cord-289152-w5ynbewh	26	13	interstitial	interstitial	JJ
cord-289152-w5ynbewh	26	14	pneumonia	pneumonia	NN
cord-289152-w5ynbewh	26	15	and	and	CC
cord-289152-w5ynbewh	26	16	mild	mild	JJ
cord-289152-w5ynbewh	26	17	lymphocytic	lymphocytic	JJ
cord-289152-w5ynbewh	26	18	encephalitis	encephalitis	RB
cord-289152-w5ynbewh	27	1	(	(	-LRB-
cord-289152-w5ynbewh	27	2	Halbur	Halbur	NNP
cord-289152-w5ynbewh	27	3	et	et	NNP
cord-289152-w5ynbewh	27	4	al	al	NNP
cord-289152-w5ynbewh	27	5	.	.	NNP
cord-289152-w5ynbewh	27	6	,	,	,
cord-289152-w5ynbewh	27	7	1995	1995	CD
cord-289152-w5ynbewh	27	8	;	;	:
cord-289152-w5ynbewh	27	9	Plagemann	Plagemann	NNP
cord-289152-w5ynbewh	27	10	,	,	,
cord-289152-w5ynbewh	27	11	1996	1996	CD
cord-289152-w5ynbewh	27	12	;	;	:
cord-289152-w5ynbewh	27	13	Rossow	Rossow	NNP
cord-289152-w5ynbewh	27	14	et	et	NNP
cord-289152-w5ynbewh	27	15	al	al	NNP
cord-289152-w5ynbewh	27	16	.	.	NNP
cord-289152-w5ynbewh	27	17	,	,	,
cord-289152-w5ynbewh	27	18	1995	1995	CD
cord-289152-w5ynbewh	28	1	Rossow	Rossow	NNP
cord-289152-w5ynbewh	28	2	et	et	NNP
cord-289152-w5ynbewh	28	3	al	al	NNP
cord-289152-w5ynbewh	28	4	.	.	NNP
cord-289152-w5ynbewh	28	5	,	,	,
cord-289152-w5ynbewh	28	6	,	,	,
cord-289152-w5ynbewh	28	7	1996	1996	CD
cord-289152-w5ynbewh	28	8	.	.	.
cord-289152-w5ynbewh	29	1	Tissue	tissue	NN
cord-289152-w5ynbewh	29	2	macrophages	macrophage	NNS
cord-289152-w5ynbewh	29	3	and	and	CC
cord-289152-w5ynbewh	29	4	monocytes	monocyte	NNS
cord-289152-w5ynbewh	29	5	are	be	VBP
cord-289152-w5ynbewh	29	6	the	the	DT
cord-289152-w5ynbewh	29	7	major	major	JJ
cord-289152-w5ynbewh	29	8	target	target	NN
cord-289152-w5ynbewh	29	9	cells	cell	NNS
cord-289152-w5ynbewh	29	10	during	during	IN
cord-289152-w5ynbewh	29	11	both	both	CC
cord-289152-w5ynbewh	29	12	acute	acute	JJ
cord-289152-w5ynbewh	29	13	and	and	CC
cord-289152-w5ynbewh	29	14	persistent	persistent	JJ
cord-289152-w5ynbewh	29	15	infection	infection	NN
cord-289152-w5ynbewh	29	16	(	(	-LRB-
cord-289152-w5ynbewh	29	17	Molitor	Molitor	NNP
cord-289152-w5ynbewh	29	18	et	et	NNP
cord-289152-w5ynbewh	29	19	al	al	NNP
cord-289152-w5ynbewh	29	20	.	.	NNP
cord-289152-w5ynbewh	29	21	,	,	,
cord-289152-w5ynbewh	29	22	1997	1997	CD
cord-289152-w5ynbewh	29	23	)	)	-RRB-
cord-289152-w5ynbewh	29	24	,	,	,
cord-289152-w5ynbewh	29	25	although	although	IN
cord-289152-w5ynbewh	29	26	pneumocytes	pneumocyte	NNS
cord-289152-w5ynbewh	29	27	and	and	CC
cord-289152-w5ynbewh	29	28	epithelial	epithelial	JJ
cord-289152-w5ynbewh	29	29	germ	germ	NN
cord-289152-w5ynbewh	29	30	cells	cell	NNS
cord-289152-w5ynbewh	29	31	of	of	IN
cord-289152-w5ynbewh	29	32	the	the	DT
cord-289152-w5ynbewh	29	33	testis	testis	NN
cord-289152-w5ynbewh	29	34	have	have	VBP
cord-289152-w5ynbewh	29	35	also	also	RB
cord-289152-w5ynbewh	29	36	been	be	VBN
cord-289152-w5ynbewh	29	37	shown	show	VBN
cord-289152-w5ynbewh	29	38	to	to	TO
cord-289152-w5ynbewh	29	39	be	be	VB
cord-289152-w5ynbewh	29	40	infected	infect	VBN
cord-289152-w5ynbewh	30	1	(	(	-LRB-
cord-289152-w5ynbewh	30	2	Sur	sur	FW
cord-289152-w5ynbewh	30	3	et	et	FW
cord-289152-w5ynbewh	30	4	al	al	NNP
cord-289152-w5ynbewh	30	5	.	.	.
cord-289152-w5ynbewh	31	1	,	,	,
cord-289152-w5ynbewh	31	2	1996	1996	CD
cord-289152-w5ynbewh	32	1	(	(	-LRB-
cord-289152-w5ynbewh	32	2	Sur	sur	FW
cord-289152-w5ynbewh	32	3	et	et	FW
cord-289152-w5ynbewh	32	4	al	al	NNP
cord-289152-w5ynbewh	32	5	.	.	NNP
cord-289152-w5ynbewh	32	6	,	,	,
cord-289152-w5ynbewh	32	7	,	,	,
cord-289152-w5ynbewh	32	8	1997	1997	CD
cord-289152-w5ynbewh	32	9	.	.	.
cord-289152-w5ynbewh	33	1	Viruses	virus	NNS
cord-289152-w5ynbewh	33	2	are	be	VBP
cord-289152-w5ynbewh	33	3	known	know	VBN
cord-289152-w5ynbewh	33	4	to	to	TO
cord-289152-w5ynbewh	33	5	control	control	VB
cord-289152-w5ynbewh	33	6	cellular	cellular	JJ
cord-289152-w5ynbewh	33	7	signal	signal	NN
cord-289152-w5ynbewh	33	8	transduction	transduction	NN
cord-289152-w5ynbewh	33	9	pathways	pathway	NNS
cord-289152-w5ynbewh	33	10	,	,	,
cord-289152-w5ynbewh	33	11	and	and	CC
cord-289152-w5ynbewh	33	12	the	the	DT
cord-289152-w5ynbewh	33	13	NF	nf	NN
cord-289152-w5ynbewh	33	14	-	-	HYPH
cord-289152-w5ynbewh	33	15	nB	nB	NNP
cord-289152-w5ynbewh	33	16	pathway	pathway	NN
cord-289152-w5ynbewh	33	17	is	be	VBZ
cord-289152-w5ynbewh	33	18	a	a	DT
cord-289152-w5ynbewh	33	19	common	common	JJ
cord-289152-w5ynbewh	33	20	target	target	NN
cord-289152-w5ynbewh	33	21	of	of	IN
cord-289152-w5ynbewh	33	22	many	many	JJ
cord-289152-w5ynbewh	33	23	viruses	virus	NNS
cord-289152-w5ynbewh	33	24	.	.	.
cord-289152-w5ynbewh	34	1	NF	NF	NNP
cord-289152-w5ynbewh	34	2	-	-	HYPH
cord-289152-w5ynbewh	34	3	nB	nB	NNP
cord-289152-w5ynbewh	34	4	is	be	VBZ
cord-289152-w5ynbewh	34	5	an	an	DT
cord-289152-w5ynbewh	34	6	inducible	inducible	JJ
cord-289152-w5ynbewh	34	7	transcription	transcription	NN
cord-289152-w5ynbewh	34	8	factor	factor	NN
cord-289152-w5ynbewh	34	9	that	that	WDT
cord-289152-w5ynbewh	34	10	plays	play	VBZ
cord-289152-w5ynbewh	34	11	a	a	DT
cord-289152-w5ynbewh	34	12	key	key	JJ
cord-289152-w5ynbewh	34	13	role	role	NN
cord-289152-w5ynbewh	34	14	in	in	IN
cord-289152-w5ynbewh	34	15	inflammation	inflammation	NN
cord-289152-w5ynbewh	34	16	,	,	,
cord-289152-w5ynbewh	34	17	innate	innate	JJ
cord-289152-w5ynbewh	34	18	immune	immune	JJ
cord-289152-w5ynbewh	34	19	responses	response	NNS
cord-289152-w5ynbewh	34	20	,	,	,
cord-289152-w5ynbewh	34	21	the	the	DT
cord-289152-w5ynbewh	34	22	regulation	regulation	NN
cord-289152-w5ynbewh	34	23	of	of	IN
cord-289152-w5ynbewh	34	24	cell	cell	NN
cord-289152-w5ynbewh	34	25	proliferation	proliferation	NN
cord-289152-w5ynbewh	34	26	,	,	,
cord-289152-w5ynbewh	34	27	and	and	CC
cord-289152-w5ynbewh	34	28	cell	cell	NN
cord-289152-w5ynbewh	34	29	survival	survival	NN
cord-289152-w5ynbewh	34	30	(	(	-LRB-
cord-289152-w5ynbewh	34	31	Caamano	Caamano	NNP
cord-289152-w5ynbewh	34	32	and	and	CC
cord-289152-w5ynbewh	34	33	Hunter	Hunter	NNP
cord-289152-w5ynbewh	34	34	,	,	,
cord-289152-w5ynbewh	34	35	2002	2002	CD
cord-289152-w5ynbewh	34	36	;	;	:
cord-289152-w5ynbewh	34	37	Li	Li	NNP
cord-289152-w5ynbewh	34	38	and	and	CC
cord-289152-w5ynbewh	34	39	Verma	Verma	NNP
cord-289152-w5ynbewh	34	40	,	,	,
cord-289152-w5ynbewh	34	41	2002	2002	CD
cord-289152-w5ynbewh	34	42	)	)	-RRB-
cord-289152-w5ynbewh	34	43	.	.	.
cord-289152-w5ynbewh	35	1	Activation	activation	NN
cord-289152-w5ynbewh	35	2	of	of	IN
cord-289152-w5ynbewh	35	3	NF	nf	NN
cord-289152-w5ynbewh	35	4	-	-	HYPH
cord-289152-w5ynbewh	35	5	nB	nB	NNP
cord-289152-w5ynbewh	35	6	by	by	IN
cord-289152-w5ynbewh	35	7	viral	viral	JJ
cord-289152-w5ynbewh	35	8	infection	infection	NN
cord-289152-w5ynbewh	35	9	is	be	VBZ
cord-289152-w5ynbewh	35	10	a	a	DT
cord-289152-w5ynbewh	35	11	key	key	JJ
cord-289152-w5ynbewh	35	12	trigger	trigger	NN
cord-289152-w5ynbewh	35	13	to	to	IN
cord-289152-w5ynbewh	35	14	inducing	induce	VBG
cord-289152-w5ynbewh	35	15	type	type	NN
cord-289152-w5ynbewh	36	1	I	-PRON-	PRP
cord-289152-w5ynbewh	37	1	interferon	interferon	NNP
cord-289152-w5ynbewh	37	2	(	(	-LRB-
cord-289152-w5ynbewh	37	3	IFN	IFN	NNP
cord-289152-w5ynbewh	37	4	)	)	-RRB-
cord-289152-w5ynbewh	37	5	transcription	transcription	NN
cord-289152-w5ynbewh	37	6	and	and	CC
cord-289152-w5ynbewh	37	7	other	other	JJ
cord-289152-w5ynbewh	37	8	immune	immune	JJ
cord-289152-w5ynbewh	37	9	responses	response	NNS
cord-289152-w5ynbewh	37	10	,	,	,
cord-289152-w5ynbewh	37	11	including	include	VBG
cord-289152-w5ynbewh	37	12	pro	pro	JJ
cord-289152-w5ynbewh	37	13	-	-	JJ
cord-289152-w5ynbewh	37	14	inflammatory	inflammatory	JJ
cord-289152-w5ynbewh	37	15	cytokines	cytokine	NNS
cord-289152-w5ynbewh	37	16	,	,	,
cord-289152-w5ynbewh	37	17	chemokines	chemokine	NNS
cord-289152-w5ynbewh	37	18	,	,	,
cord-289152-w5ynbewh	37	19	adhesion	adhesion	NN
cord-289152-w5ynbewh	37	20	molecules	molecule	NNS
cord-289152-w5ynbewh	37	21	,	,	,
cord-289152-w5ynbewh	37	22	matrix	matrix	NN
cord-289152-w5ynbewh	37	23	metalloproteinases	metalloproteinase	NNS
cord-289152-w5ynbewh	37	24	(	(	-LRB-
cord-289152-w5ynbewh	37	25	MMPs	MMPs	NNP
cord-289152-w5ynbewh	37	26	)	)	-RRB-
cord-289152-w5ynbewh	37	27	,	,	,
cord-289152-w5ynbewh	37	28	cyclooxygenase	cyclooxygenase	NN
cord-289152-w5ynbewh	37	29	2	2	CD
cord-289152-w5ynbewh	37	30	(	(	-LRB-
cord-289152-w5ynbewh	37	31	COX2	COX2	NNP
cord-289152-w5ynbewh	37	32	)	)	-RRB-
cord-289152-w5ynbewh	37	33	,	,	,
cord-289152-w5ynbewh	37	34	and	and	CC
cord-289152-w5ynbewh	37	35	inducible	inducible	JJ
cord-289152-w5ynbewh	37	36	nitric	nitric	NN
cord-289152-w5ynbewh	37	37	oxide	oxide	NN
cord-289152-w5ynbewh	37	38	synthase	synthase	NN
cord-289152-w5ynbewh	37	39	(	(	-LRB-
cord-289152-w5ynbewh	37	40	iNOS	inos	NN
cord-289152-w5ynbewh	37	41	)	)	-RRB-
cord-289152-w5ynbewh	38	1	(	(	-LRB-
cord-289152-w5ynbewh	38	2	Caamano	Caamano	NNP
cord-289152-w5ynbewh	38	3	and	and	CC
cord-289152-w5ynbewh	38	4	Hunter	Hunter	NNP
cord-289152-w5ynbewh	38	5	,	,	,
cord-289152-w5ynbewh	38	6	2002	2002	CD
cord-289152-w5ynbewh	38	7	;	;	:
cord-289152-w5ynbewh	38	8	Santoro	Santoro	NNP
cord-289152-w5ynbewh	38	9	et	et	NNP
cord-289152-w5ynbewh	38	10	al	al	NNP
cord-289152-w5ynbewh	38	11	.	.	NNP
cord-289152-w5ynbewh	38	12	,	,	,
cord-289152-w5ynbewh	38	13	2003	2003	CD
cord-289152-w5ynbewh	38	14	)	)	-RRB-
cord-289152-w5ynbewh	38	15	.	.	.
cord-289152-w5ynbewh	39	1	These	these	DT
cord-289152-w5ynbewh	39	2	molecules	molecule	NNS
cord-289152-w5ynbewh	39	3	are	be	VBP
cord-289152-w5ynbewh	39	4	involved	involve	VBN
cord-289152-w5ynbewh	39	5	in	in	IN
cord-289152-w5ynbewh	39	6	initiating	initiate	VBG
cord-289152-w5ynbewh	39	7	adaptive	adaptive	JJ
cord-289152-w5ynbewh	39	8	immune	immune	JJ
cord-289152-w5ynbewh	39	9	responses	response	NNS
cord-289152-w5ynbewh	39	10	by	by	IN
cord-289152-w5ynbewh	39	11	recruiting	recruit	VBG
cord-289152-w5ynbewh	39	12	immune	immune	JJ
cord-289152-w5ynbewh	39	13	cells	cell	NNS
cord-289152-w5ynbewh	39	14	to	to	IN
cord-289152-w5ynbewh	39	15	the	the	DT
cord-289152-w5ynbewh	39	16	site	site	NN
cord-289152-w5ynbewh	39	17	of	of	IN
cord-289152-w5ynbewh	39	18	infection	infection	NN
cord-289152-w5ynbewh	39	19	.	.	.
cord-289152-w5ynbewh	40	1	Furthermore	furthermore	RB
cord-289152-w5ynbewh	40	2	,	,	,
cord-289152-w5ynbewh	40	3	it	-PRON-	PRP
cord-289152-w5ynbewh	40	4	was	be	VBD
cord-289152-w5ynbewh	40	5	recently	recently	RB
cord-289152-w5ynbewh	40	6	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	40	7	that	that	IN
cord-289152-w5ynbewh	40	8	temporally	temporally	RB
cord-289152-w5ynbewh	40	9	activated	activate	VBN
cord-289152-w5ynbewh	40	10	NF	nf	NN
cord-289152-w5ynbewh	40	11	-	-	HYPH
cord-289152-w5ynbewh	40	12	nB	nB	NNP
cord-289152-w5ynbewh	40	13	confers	confer	VBZ
cord-289152-w5ynbewh	40	14	an	an	DT
cord-289152-w5ynbewh	40	15	essential	essential	JJ
cord-289152-w5ynbewh	40	16	innate	innate	JJ
cord-289152-w5ynbewh	40	17	antiviral	antiviral	JJ
cord-289152-w5ynbewh	40	18	response	response	NN
cord-289152-w5ynbewh	40	19	against	against	IN
cord-289152-w5ynbewh	40	20	cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	40	21	RNA	RNA	NNP
cord-289152-w5ynbewh	40	22	viruses	virus	NNS
cord-289152-w5ynbewh	40	23	(	(	-LRB-
cord-289152-w5ynbewh	40	24	human	human	JJ
cord-289152-w5ynbewh	40	25	parainfluenza	parainfluenza	NNP
cord-289152-w5ynbewh	40	26	virus	virus	NNP
cord-289152-w5ynbewh	40	27	type	type	NNP
cord-289152-w5ynbewh	40	28	3	3	CD
cord-289152-w5ynbewh	40	29	and	and	CC
cord-289152-w5ynbewh	40	30	respiratory	respiratory	JJ
cord-289152-w5ynbewh	40	31	syncytial	syncytial	JJ
cord-289152-w5ynbewh	40	32	virus	virus	NN
cord-289152-w5ynbewh	40	33	)	)	-RRB-
cord-289152-w5ynbewh	40	34	in	in	IN
cord-289152-w5ynbewh	40	35	an	an	DT
cord-289152-w5ynbewh	40	36	IFN	IFN	NNP
cord-289152-w5ynbewh	40	37	-	-	HYPH
cord-289152-w5ynbewh	40	38	independent	independent	JJ
cord-289152-w5ynbewh	40	39	manner	manner	NN
cord-289152-w5ynbewh	40	40	,	,	,
cord-289152-w5ynbewh	40	41	showing	show	VBG
cord-289152-w5ynbewh	40	42	the	the	DT
cord-289152-w5ynbewh	40	43	importance	importance	NN
cord-289152-w5ynbewh	40	44	of	of	IN
cord-289152-w5ynbewh	40	45	NF	nf	NN
cord-289152-w5ynbewh	40	46	-	-	HYPH
cord-289152-w5ynbewh	40	47	nB	nb	NN
cord-289152-w5ynbewh	40	48	in	in	IN
cord-289152-w5ynbewh	40	49	the	the	DT
cord-289152-w5ynbewh	40	50	innate	innate	JJ
cord-289152-w5ynbewh	40	51	antiviral	antiviral	JJ
cord-289152-w5ynbewh	40	52	response	response	NN
cord-289152-w5ynbewh	40	53	(	(	-LRB-
cord-289152-w5ynbewh	40	54	Bose	Bose	NNP
cord-289152-w5ynbewh	40	55	et	et	NNP
cord-289152-w5ynbewh	40	56	al	al	NNP
cord-289152-w5ynbewh	40	57	.	.	NNP
cord-289152-w5ynbewh	40	58	,	,	,
cord-289152-w5ynbewh	40	59	2003	2003	CD
cord-289152-w5ynbewh	40	60	)	)	-RRB-
cord-289152-w5ynbewh	40	61	.	.	.
cord-289152-w5ynbewh	41	1	NF	nf	NN
cord-289152-w5ynbewh	41	2	-	-	HYPH
cord-289152-w5ynbewh	41	3	nB	nB	NNP
cord-289152-w5ynbewh	41	4	exists	exist	VBZ
cord-289152-w5ynbewh	41	5	as	as	IN
cord-289152-w5ynbewh	41	6	a	a	DT
cord-289152-w5ynbewh	41	7	homodimer	homodimer	JJ
cord-289152-w5ynbewh	41	8	or	or	CC
cord-289152-w5ynbewh	41	9	heterodimer	heterodimer	NN
cord-289152-w5ynbewh	41	10	comprised	comprise	VBN
cord-289152-w5ynbewh	41	11	of	of	IN
cord-289152-w5ynbewh	41	12	one	one	CD
cord-289152-w5ynbewh	41	13	or	or	CC
cord-289152-w5ynbewh	41	14	two	two	CD
cord-289152-w5ynbewh	41	15	of	of	IN
cord-289152-w5ynbewh	41	16	five	five	CD
cord-289152-w5ynbewh	41	17	subunits	subunit	NNS
cord-289152-w5ynbewh	41	18	,	,	,
cord-289152-w5ynbewh	41	19	RelA	RelA	NNP
cord-289152-w5ynbewh	41	20	(	(	-LRB-
cord-289152-w5ynbewh	41	21	p65	p65	NN
cord-289152-w5ynbewh	41	22	)	)	-RRB-
cord-289152-w5ynbewh	41	23	,	,	,
cord-289152-w5ynbewh	41	24	p50	p50	NN
cord-289152-w5ynbewh	41	25	,	,	,
cord-289152-w5ynbewh	41	26	RelB	relb	NN
cord-289152-w5ynbewh	41	27	,	,	,
cord-289152-w5ynbewh	41	28	c	c	NN
cord-289152-w5ynbewh	41	29	-	-	:
cord-289152-w5ynbewh	41	30	Rel	Rel	NNP
cord-289152-w5ynbewh	41	31	,	,	,
cord-289152-w5ynbewh	41	32	and	and	CC
cord-289152-w5ynbewh	41	33	p52	p52	NN
cord-289152-w5ynbewh	41	34	.	.	.
cord-289152-w5ynbewh	42	1	The	the	DT
cord-289152-w5ynbewh	42	2	predominant	predominant	JJ
cord-289152-w5ynbewh	42	3	form	form	NN
cord-289152-w5ynbewh	42	4	is	be	VBZ
cord-289152-w5ynbewh	42	5	a	a	DT
cord-289152-w5ynbewh	42	6	heterodimer	heterodimer	NN
cord-289152-w5ynbewh	42	7	composed	compose	VBN
cord-289152-w5ynbewh	42	8	of	of	IN
cord-289152-w5ynbewh	42	9	p50	p50	NN
cord-289152-w5ynbewh	42	10	and	and	CC
cord-289152-w5ynbewh	42	11	RelA	RelA	NNP
cord-289152-w5ynbewh	42	12	subunits	subunit	NNS
cord-289152-w5ynbewh	42	13	.	.	.
cord-289152-w5ynbewh	43	1	When	when	WRB
cord-289152-w5ynbewh	43	2	inactive	inactive	JJ
cord-289152-w5ynbewh	43	3	,	,	,
cord-289152-w5ynbewh	43	4	NF	nf	NN
cord-289152-w5ynbewh	43	5	-	-	HYPH
cord-289152-w5ynbewh	43	6	nB	nB	NNP
cord-289152-w5ynbewh	43	7	is	be	VBZ
cord-289152-w5ynbewh	43	8	sequestered	sequester	VBN
cord-289152-w5ynbewh	43	9	in	in	IN
cord-289152-w5ynbewh	43	10	the	the	DT
cord-289152-w5ynbewh	43	11	cytoplasm	cytoplasm	NN
cord-289152-w5ynbewh	43	12	by	by	IN
cord-289152-w5ynbewh	43	13	associating	associate	VBG
cord-289152-w5ynbewh	43	14	with	with	IN
cord-289152-w5ynbewh	43	15	inhibitory	inhibitory	JJ
cord-289152-w5ynbewh	43	16	proteins	protein	NNS
cord-289152-w5ynbewh	43	17	of	of	IN
cord-289152-w5ynbewh	43	18	the	the	DT
cord-289152-w5ynbewh	43	19	InB	inb	NN
cord-289152-w5ynbewh	43	20	family	family	NN
cord-289152-w5ynbewh	43	21	,	,	,
cord-289152-w5ynbewh	43	22	including	include	VBG
cord-289152-w5ynbewh	43	23	InBa	InBa	NNP
cord-289152-w5ynbewh	43	24	,	,	,
cord-289152-w5ynbewh	43	25	InBh	InBh	NNP
cord-289152-w5ynbewh	43	26	,	,	,
cord-289152-w5ynbewh	43	27	and	and	CC
cord-289152-w5ynbewh	43	28	InBe	InBe	NNP
cord-289152-w5ynbewh	43	29	,	,	,
cord-289152-w5ynbewh	43	30	which	which	WDT
cord-289152-w5ynbewh	43	31	mask	mask	VBP
cord-289152-w5ynbewh	43	32	the	the	DT
cord-289152-w5ynbewh	43	33	nuclear	nuclear	JJ
cord-289152-w5ynbewh	43	34	localization	localization	NN
cord-289152-w5ynbewh	43	35	signal	signal	NN
cord-289152-w5ynbewh	43	36	.	.	.
cord-289152-w5ynbewh	44	1	In	in	IN
cord-289152-w5ynbewh	44	2	response	response	NN
cord-289152-w5ynbewh	44	3	to	to	IN
cord-289152-w5ynbewh	44	4	a	a	DT
cord-289152-w5ynbewh	44	5	wide	wide	JJ
cord-289152-w5ynbewh	44	6	range	range	NN
cord-289152-w5ynbewh	44	7	of	of	IN
cord-289152-w5ynbewh	44	8	stress	stress	NN
cord-289152-w5ynbewh	44	9	signals	signal	NNS
cord-289152-w5ynbewh	44	10	(	(	-LRB-
cord-289152-w5ynbewh	44	11	e.g.	e.g.	RB
cord-289152-w5ynbewh	44	12	,	,	,
cord-289152-w5ynbewh	44	13	lipopolysaccharide	lipopolysaccharide	NN
cord-289152-w5ynbewh	44	14	(	(	-LRB-
cord-289152-w5ynbewh	44	15	LPS	LPS	NNP
cord-289152-w5ynbewh	44	16	)	)	-RRB-
cord-289152-w5ynbewh	44	17	,	,	,
cord-289152-w5ynbewh	44	18	tumor	tumor	NN
cord-289152-w5ynbewh	44	19	necrosis	necrosis	NN
cord-289152-w5ynbewh	44	20	factor	factor	NN
cord-289152-w5ynbewh	44	21	(	(	-LRB-
cord-289152-w5ynbewh	44	22	TNF	TNF	NNP
cord-289152-w5ynbewh	44	23	)	)	-RRB-
cord-289152-w5ynbewh	44	24	,	,	,
cord-289152-w5ynbewh	44	25	interleukin	interleukin	FW
cord-289152-w5ynbewh	44	26	(	(	-LRB-
cord-289152-w5ynbewh	44	27	IL)-1	IL)-1	NNP
cord-289152-w5ynbewh	44	28	,	,	,
cord-289152-w5ynbewh	44	29	and	and	CC
cord-289152-w5ynbewh	44	30	virus	virus	NN
cord-289152-w5ynbewh	44	31	infection	infection	NN
cord-289152-w5ynbewh	44	32	)	)	-RRB-
cord-289152-w5ynbewh	44	33	,	,	,
cord-289152-w5ynbewh	44	34	the	the	DT
cord-289152-w5ynbewh	44	35	inactive	inactive	JJ
cord-289152-w5ynbewh	44	36	NF	nf	NN
cord-289152-w5ynbewh	44	37	-	-	HYPH
cord-289152-w5ynbewh	44	38	nB	nb	NN
cord-289152-w5ynbewh	44	39	-	-	HYPH
cord-289152-w5ynbewh	44	40	InB	inb	NN
cord-289152-w5ynbewh	44	41	complex	complex	NN
cord-289152-w5ynbewh	44	42	is	be	VBZ
cord-289152-w5ynbewh	44	43	dissociated	dissociate	VBN
cord-289152-w5ynbewh	44	44	via	via	IN
cord-289152-w5ynbewh	44	45	serine	serine	JJ
cord-289152-w5ynbewh	44	46	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	44	47	by	by	IN
cord-289152-w5ynbewh	44	48	InB	inb	NN
cord-289152-w5ynbewh	44	49	kinase	kinase	NN
cord-289152-w5ynbewh	44	50	(	(	-LRB-
cord-289152-w5ynbewh	44	51	IKK	IKK	NNP
cord-289152-w5ynbewh	44	52	)	)	-RRB-
cord-289152-w5ynbewh	44	53	and	and	CC
cord-289152-w5ynbewh	44	54	degradation	degradation	NN
cord-289152-w5ynbewh	44	55	of	of	IN
cord-289152-w5ynbewh	44	56	InB	inb	NN
cord-289152-w5ynbewh	44	57	in	in	IN
cord-289152-w5ynbewh	44	58	proteasomes	proteasomes	NNP
cord-289152-w5ynbewh	44	59	.	.	.
cord-289152-w5ynbewh	45	1	These	these	DT
cord-289152-w5ynbewh	45	2	events	event	NNS
cord-289152-w5ynbewh	45	3	lead	lead	VBP
cord-289152-w5ynbewh	45	4	to	to	IN
cord-289152-w5ynbewh	45	5	the	the	DT
cord-289152-w5ynbewh	45	6	unmasking	unmasking	NN
cord-289152-w5ynbewh	45	7	of	of	IN
cord-289152-w5ynbewh	45	8	the	the	DT
cord-289152-w5ynbewh	45	9	nuclear	nuclear	JJ
cord-289152-w5ynbewh	45	10	localization	localization	NN
cord-289152-w5ynbewh	45	11	sequence	sequence	NN
cord-289152-w5ynbewh	45	12	of	of	IN
cord-289152-w5ynbewh	45	13	NF	nf	NN
cord-289152-w5ynbewh	45	14	-	-	HYPH
cord-289152-w5ynbewh	45	15	nB	nB	NNP
cord-289152-w5ynbewh	45	16	,	,	,
cord-289152-w5ynbewh	45	17	which	which	WDT
cord-289152-w5ynbewh	45	18	then	then	RB
cord-289152-w5ynbewh	45	19	allows	allow	VBZ
cord-289152-w5ynbewh	45	20	NF	nf	NN
cord-289152-w5ynbewh	45	21	-	-	HYPH
cord-289152-w5ynbewh	45	22	nB	nB	NNP
cord-289152-w5ynbewh	45	23	to	to	TO
cord-289152-w5ynbewh	45	24	enter	enter	VB
cord-289152-w5ynbewh	45	25	the	the	DT
cord-289152-w5ynbewh	45	26	nucleus	nucleus	NN
cord-289152-w5ynbewh	45	27	and	and	CC
cord-289152-w5ynbewh	45	28	activate	activate	VB
cord-289152-w5ynbewh	45	29	transcription	transcription	NN
cord-289152-w5ynbewh	45	30	of	of	IN
cord-289152-w5ynbewh	45	31	target	target	NN
cord-289152-w5ynbewh	45	32	genes	gene	NNS
cord-289152-w5ynbewh	45	33	.	.	.
cord-289152-w5ynbewh	46	1	While	while	IN
cord-289152-w5ynbewh	46	2	the	the	DT
cord-289152-w5ynbewh	46	3	immune	immune	JJ
cord-289152-w5ynbewh	46	4	response	response	NN
cord-289152-w5ynbewh	46	5	against	against	IN
cord-289152-w5ynbewh	46	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	46	7	is	be	VBZ
cord-289152-w5ynbewh	46	8	not	not	RB
cord-289152-w5ynbewh	46	9	fully	fully	RB
cord-289152-w5ynbewh	46	10	characterized	characterize	VBN
cord-289152-w5ynbewh	46	11	,	,	,
cord-289152-w5ynbewh	46	12	experimental	experimental	JJ
cord-289152-w5ynbewh	46	13	work	work	NN
cord-289152-w5ynbewh	46	14	has	have	VBZ
cord-289152-w5ynbewh	46	15	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	46	16	that	that	IN
cord-289152-w5ynbewh	46	17	the	the	DT
cord-289152-w5ynbewh	46	18	adaptive	adaptive	JJ
cord-289152-w5ynbewh	46	19	immune	immune	JJ
cord-289152-w5ynbewh	46	20	response	response	NN
cord-289152-w5ynbewh	46	21	of	of	IN
cord-289152-w5ynbewh	46	22	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	46	23	-	-	HYPH
cord-289152-w5ynbewh	46	24	infected	infect	VBN
cord-289152-w5ynbewh	46	25	pigs	pig	NNS
cord-289152-w5ynbewh	46	26	is	be	VBZ
cord-289152-w5ynbewh	46	27	generally	generally	RB
cord-289152-w5ynbewh	46	28	ineffective	ineffective	JJ
cord-289152-w5ynbewh	47	1	(	(	-LRB-
cord-289152-w5ynbewh	47	2	Horter	Horter	NNP
cord-289152-w5ynbewh	47	3	et	et	NNP
cord-289152-w5ynbewh	47	4	al	al	NNP
cord-289152-w5ynbewh	47	5	.	.	NNP
cord-289152-w5ynbewh	47	6	,	,	,
cord-289152-w5ynbewh	47	7	2002	2002	CD
cord-289152-w5ynbewh	47	8	;	;	:
cord-289152-w5ynbewh	47	9	Murtaugh	Murtaugh	NNP
cord-289152-w5ynbewh	47	10	et	et	FW
cord-289152-w5ynbewh	47	11	al	al	NNP
cord-289152-w5ynbewh	47	12	.	.	NNP
cord-289152-w5ynbewh	47	13	,	,	,
cord-289152-w5ynbewh	47	14	2002	2002	CD
cord-289152-w5ynbewh	47	15	;	;	:
cord-289152-w5ynbewh	47	16	Wills	Wills	NNP
cord-289152-w5ynbewh	47	17	et	et	NNP
cord-289152-w5ynbewh	47	18	al	al	NNP
cord-289152-w5ynbewh	47	19	.	.	.
cord-289152-w5ynbewh	48	1	,	,	,
cord-289152-w5ynbewh	48	2	1997	1997	CD
cord-289152-w5ynbewh	49	1	Wills	Wills	NNP
cord-289152-w5ynbewh	49	2	et	et	NNP
cord-289152-w5ynbewh	49	3	al	al	NNP
cord-289152-w5ynbewh	49	4	.	.	NNP
cord-289152-w5ynbewh	49	5	,	,	,
cord-289152-w5ynbewh	49	6	,	,	,
cord-289152-w5ynbewh	49	7	2003	2003	CD
cord-289152-w5ynbewh	49	8	.	.	.
cord-289152-w5ynbewh	50	1	Specific	specific	JJ
cord-289152-w5ynbewh	50	2	evidence	evidence	NN
cord-289152-w5ynbewh	50	3	of	of	IN
cord-289152-w5ynbewh	50	4	an	an	DT
cord-289152-w5ynbewh	50	5	ineffective	ineffective	JJ
cord-289152-w5ynbewh	50	6	adaptive	adaptive	JJ
cord-289152-w5ynbewh	50	7	immune	immune	JJ
cord-289152-w5ynbewh	50	8	response	response	NN
cord-289152-w5ynbewh	50	9	includes	include	VBZ
cord-289152-w5ynbewh	50	10	a	a	DT
cord-289152-w5ynbewh	50	11	slow	slow	JJ
cord-289152-w5ynbewh	50	12	neutralizing	neutralize	VBG
cord-289152-w5ynbewh	50	13	antibody	antibody	NN
cord-289152-w5ynbewh	50	14	response	response	NN
cord-289152-w5ynbewh	50	15	,	,	,
cord-289152-w5ynbewh	50	16	which	which	WDT
cord-289152-w5ynbewh	50	17	is	be	VBZ
cord-289152-w5ynbewh	50	18	typically	typically	RB
cord-289152-w5ynbewh	50	19	not	not	RB
cord-289152-w5ynbewh	50	20	detected	detect	VBN
cord-289152-w5ynbewh	50	21	until	until	IN
cord-289152-w5ynbewh	50	22	3	3	CD
cord-289152-w5ynbewh	50	23	weeks	week	NNS
cord-289152-w5ynbewh	50	24	p.i	p.i	NNP
cord-289152-w5ynbewh	50	25	.	.	.
cord-289152-w5ynbewh	51	1	(	(	-LRB-
cord-289152-w5ynbewh	51	2	Albina	Albina	NNP
cord-289152-w5ynbewh	51	3	et	et	NNP
cord-289152-w5ynbewh	51	4	al	al	NNP
cord-289152-w5ynbewh	51	5	.	.	NNP
cord-289152-w5ynbewh	51	6	,	,	,
cord-289152-w5ynbewh	51	7	1998b	1998b	CD
cord-289152-w5ynbewh	51	8	)	)	-RRB-
cord-289152-w5ynbewh	52	1	and	and	CC
cord-289152-w5ynbewh	52	2	does	do	VBZ
cord-289152-w5ynbewh	52	3	not	not	RB
cord-289152-w5ynbewh	52	4	reach	reach	VB
cord-289152-w5ynbewh	52	5	maximum	maximum	JJ
cord-289152-w5ynbewh	52	6	levels	level	NNS
cord-289152-w5ynbewh	52	7	until	until	IN
cord-289152-w5ynbewh	52	8	10	10	CD
cord-289152-w5ynbewh	52	9	-18	-18	SYM
cord-289152-w5ynbewh	52	10	weeks	week	NNS
cord-289152-w5ynbewh	52	11	p.i	p.i	NNP
cord-289152-w5ynbewh	52	12	.	.	.
cord-289152-w5ynbewh	53	1	(	(	-LRB-
cord-289152-w5ynbewh	53	2	Nelson	Nelson	NNP
cord-289152-w5ynbewh	53	3	et	et	NNP
cord-289152-w5ynbewh	53	4	al	al	NNP
cord-289152-w5ynbewh	53	5	.	.	NNP
cord-289152-w5ynbewh	53	6	,	,	,
cord-289152-w5ynbewh	53	7	1994	1994	CD
cord-289152-w5ynbewh	54	1	;	;	:
cord-289152-w5ynbewh	54	2	Yoon	Yoon	NNP
cord-289152-w5ynbewh	54	3	et	et	NNP
cord-289152-w5ynbewh	54	4	al	al	NNP
cord-289152-w5ynbewh	54	5	.	.	NNP
cord-289152-w5ynbewh	54	6	,	,	,
cord-289152-w5ynbewh	54	7	1995	1995	CD
cord-289152-w5ynbewh	54	8	)	)	-RRB-
cord-289152-w5ynbewh	54	9	.	.	.
cord-289152-w5ynbewh	55	1	While	while	IN
cord-289152-w5ynbewh	55	2	the	the	DT
cord-289152-w5ynbewh	55	3	importance	importance	NN
cord-289152-w5ynbewh	55	4	of	of	IN
cord-289152-w5ynbewh	55	5	a	a	DT
cord-289152-w5ynbewh	55	6	cellmediated	cellmediate	VBN
cord-289152-w5ynbewh	55	7	response	response	NN
cord-289152-w5ynbewh	55	8	for	for	IN
cord-289152-w5ynbewh	55	9	protection	protection	NN
cord-289152-w5ynbewh	55	10	against	against	IN
cord-289152-w5ynbewh	55	11	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	55	12	is	be	VBZ
cord-289152-w5ynbewh	55	13	well	well	RB
cord-289152-w5ynbewh	55	14	accepted	accept	VBN
cord-289152-w5ynbewh	55	15	,	,	,
cord-289152-w5ynbewh	55	16	the	the	DT
cord-289152-w5ynbewh	55	17	effectiveness	effectiveness	NN
cord-289152-w5ynbewh	55	18	of	of	IN
cord-289152-w5ynbewh	55	19	this	this	DT
cord-289152-w5ynbewh	55	20	response	response	NN
cord-289152-w5ynbewh	55	21	during	during	IN
cord-289152-w5ynbewh	55	22	the	the	DT
cord-289152-w5ynbewh	55	23	early	early	JJ
cord-289152-w5ynbewh	55	24	phases	phase	NNS
cord-289152-w5ynbewh	55	25	of	of	IN
cord-289152-w5ynbewh	55	26	disease	disease	NN
cord-289152-w5ynbewh	55	27	also	also	RB
cord-289152-w5ynbewh	55	28	appears	appear	VBZ
cord-289152-w5ynbewh	55	29	to	to	TO
cord-289152-w5ynbewh	55	30	be	be	VB
cord-289152-w5ynbewh	55	31	suboptimal	suboptimal	JJ
cord-289152-w5ynbewh	56	1	(	(	-LRB-
cord-289152-w5ynbewh	56	2	Murtaugh	Murtaugh	NNP
cord-289152-w5ynbewh	56	3	et	et	FW
cord-289152-w5ynbewh	56	4	al	al	NNP
cord-289152-w5ynbewh	56	5	.	.	NNP
cord-289152-w5ynbewh	56	6	,	,	,
cord-289152-w5ynbewh	56	7	2002	2002	CD
cord-289152-w5ynbewh	56	8	)	)	-RRB-
cord-289152-w5ynbewh	56	9	.	.	.
cord-289152-w5ynbewh	57	1	For	for	IN
cord-289152-w5ynbewh	57	2	example	example	NN
cord-289152-w5ynbewh	57	3	,	,	,
cord-289152-w5ynbewh	57	4	the	the	DT
cord-289152-w5ynbewh	57	5	T	t	NN
cord-289152-w5ynbewh	57	6	-	-	HYPH
cord-289152-w5ynbewh	57	7	cell	cell	NN
cord-289152-w5ynbewh	57	8	response	response	NN
cord-289152-w5ynbewh	57	9	to	to	IN
cord-289152-w5ynbewh	57	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	57	11	is	be	VBZ
cord-289152-w5ynbewh	57	12	weak	weak	JJ
cord-289152-w5ynbewh	57	13	and	and	CC
cord-289152-w5ynbewh	57	14	transient	transient	JJ
cord-289152-w5ynbewh	57	15	and	and	CC
cord-289152-w5ynbewh	57	16	can	can	MD
cord-289152-w5ynbewh	57	17	not	not	RB
cord-289152-w5ynbewh	57	18	be	be	VB
cord-289152-w5ynbewh	57	19	re	re	VBN
cord-289152-w5ynbewh	57	20	-	-	VBN
cord-289152-w5ynbewh	57	21	stimulated	stimulate	VBN
cord-289152-w5ynbewh	57	22	for	for	IN
cord-289152-w5ynbewh	57	23	more	more	JJR
cord-289152-w5ynbewh	57	24	than	than	IN
cord-289152-w5ynbewh	57	25	4	4	CD
cord-289152-w5ynbewh	57	26	weeks	week	NNS
cord-289152-w5ynbewh	57	27	post	post	JJ
cord-289152-w5ynbewh	57	28	-	-	JJ
cord-289152-w5ynbewh	57	29	challenge	challenge	NN
cord-289152-w5ynbewh	57	30	(	(	-LRB-
cord-289152-w5ynbewh	57	31	Molitor	Molitor	NNP
cord-289152-w5ynbewh	57	32	et	et	NNP
cord-289152-w5ynbewh	57	33	al	al	NNP
cord-289152-w5ynbewh	57	34	.	.	NNP
cord-289152-w5ynbewh	57	35	,	,	,
cord-289152-w5ynbewh	57	36	1997	1997	CD
cord-289152-w5ynbewh	57	37	;	;	:
cord-289152-w5ynbewh	57	38	Xiao	Xiao	NNP
cord-289152-w5ynbewh	57	39	et	et	NNP
cord-289152-w5ynbewh	57	40	al	al	NNP
cord-289152-w5ynbewh	57	41	.	.	NNP
cord-289152-w5ynbewh	57	42	,	,	,
cord-289152-w5ynbewh	57	43	2004	2004	CD
cord-289152-w5ynbewh	57	44	)	)	-RRB-
cord-289152-w5ynbewh	57	45	.	.	.
cord-289152-w5ynbewh	58	1	Additionally	additionally	RB
cord-289152-w5ynbewh	58	2	,	,	,
cord-289152-w5ynbewh	58	3	IFN	IFN	NNP
cord-289152-w5ynbewh	58	4	-	-	HYPH
cord-289152-w5ynbewh	58	5	g	g	NNP
cord-289152-w5ynbewh	58	6	responses	response	NNS
cord-289152-w5ynbewh	58	7	of	of	IN
cord-289152-w5ynbewh	58	8	PRRSVinfected	prrsvinfected	JJ
cord-289152-w5ynbewh	58	9	pigs	pig	NNS
cord-289152-w5ynbewh	58	10	were	be	VBD
cord-289152-w5ynbewh	58	11	relatively	relatively	RB
cord-289152-w5ynbewh	58	12	weak	weak	JJ
cord-289152-w5ynbewh	58	13	and	and	CC
cord-289152-w5ynbewh	58	14	increased	increase	VBD
cord-289152-w5ynbewh	58	15	slowly	slowly	RB
cord-289152-w5ynbewh	58	16	in	in	IN
cord-289152-w5ynbewh	58	17	comparison	comparison	NN
cord-289152-w5ynbewh	58	18	to	to	IN
cord-289152-w5ynbewh	58	19	pseudorabies	pseudorabies	NN
cord-289152-w5ynbewh	58	20	-	-	HYPH
cord-289152-w5ynbewh	58	21	virus	virus	NN
cord-289152-w5ynbewh	58	22	-	-	HYPH
cord-289152-w5ynbewh	58	23	infected	infect	VBN
cord-289152-w5ynbewh	58	24	pigs	pig	NNS
cord-289152-w5ynbewh	58	25	(	(	-LRB-
cord-289152-w5ynbewh	58	26	Meier	Meier	NNP
cord-289152-w5ynbewh	58	27	et	et	NNP
cord-289152-w5ynbewh	58	28	al	al	NNP
cord-289152-w5ynbewh	58	29	.	.	NNP
cord-289152-w5ynbewh	58	30	,	,	,
cord-289152-w5ynbewh	58	31	2003	2003	CD
cord-289152-w5ynbewh	58	32	)	)	-RRB-
cord-289152-w5ynbewh	58	33	.	.	.
cord-289152-w5ynbewh	59	1	Although	although	IN
cord-289152-w5ynbewh	59	2	the	the	DT
cord-289152-w5ynbewh	59	3	precise	precise	JJ
cord-289152-w5ynbewh	59	4	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	59	5	for	for	IN
cord-289152-w5ynbewh	59	6	the	the	DT
cord-289152-w5ynbewh	59	7	ineffective	ineffective	JJ
cord-289152-w5ynbewh	59	8	nature	nature	NN
cord-289152-w5ynbewh	59	9	of	of	IN
cord-289152-w5ynbewh	59	10	the	the	DT
cord-289152-w5ynbewh	59	11	adaptive	adaptive	JJ
cord-289152-w5ynbewh	59	12	immune	immune	JJ
cord-289152-w5ynbewh	59	13	response	response	NN
cord-289152-w5ynbewh	59	14	to	to	IN
cord-289152-w5ynbewh	59	15	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	59	16	are	be	VBP
cord-289152-w5ynbewh	59	17	not	not	RB
cord-289152-w5ynbewh	59	18	known	know	VBN
cord-289152-w5ynbewh	59	19	,	,	,
cord-289152-w5ynbewh	59	20	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	59	21	evasion	evasion	NN
cord-289152-w5ynbewh	59	22	of	of	IN
cord-289152-w5ynbewh	59	23	the	the	DT
cord-289152-w5ynbewh	59	24	innate	innate	JJ
cord-289152-w5ynbewh	59	25	immune	immune	JJ
cord-289152-w5ynbewh	59	26	responses	response	NNS
cord-289152-w5ynbewh	59	27	,	,	,
cord-289152-w5ynbewh	59	28	such	such	JJ
cord-289152-w5ynbewh	59	29	as	as	IN
cord-289152-w5ynbewh	59	30	the	the	DT
cord-289152-w5ynbewh	59	31	type	type	NN
cord-289152-w5ynbewh	59	32	I	-PRON-	PRP
cord-289152-w5ynbewh	59	33	IFN	IFN	NNP
cord-289152-w5ynbewh	59	34	response	response	NN
cord-289152-w5ynbewh	59	35	,	,	,
cord-289152-w5ynbewh	59	36	may	may	MD
cord-289152-w5ynbewh	59	37	set	set	VB
cord-289152-w5ynbewh	59	38	the	the	DT
cord-289152-w5ynbewh	59	39	stage	stage	NN
cord-289152-w5ynbewh	59	40	for	for	IN
cord-289152-w5ynbewh	59	41	subsequent	subsequent	JJ
cord-289152-w5ynbewh	59	42	subversion	subversion	NN
cord-289152-w5ynbewh	59	43	of	of	IN
cord-289152-w5ynbewh	59	44	the	the	DT
cord-289152-w5ynbewh	59	45	adaptive	adaptive	JJ
cord-289152-w5ynbewh	59	46	immune	immune	JJ
cord-289152-w5ynbewh	59	47	response	response	NN
cord-289152-w5ynbewh	59	48	.	.	.
cord-289152-w5ynbewh	60	1	Previous	previous	JJ
cord-289152-w5ynbewh	60	2	studies	study	NNS
cord-289152-w5ynbewh	60	3	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	60	4	that	that	IN
cord-289152-w5ynbewh	60	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	60	6	appears	appear	VBZ
cord-289152-w5ynbewh	60	7	to	to	TO
cord-289152-w5ynbewh	60	8	elicit	elicit	VB
cord-289152-w5ynbewh	60	9	weak	weak	JJ
cord-289152-w5ynbewh	60	10	innate	innate	JJ
cord-289152-w5ynbewh	60	11	interferon	interferon	NN
cord-289152-w5ynbewh	60	12	and	and	CC
cord-289152-w5ynbewh	60	13	cytokine	cytokine	NN
cord-289152-w5ynbewh	60	14	responses	response	NNS
cord-289152-w5ynbewh	60	15	compared	compare	VBN
cord-289152-w5ynbewh	60	16	to	to	IN
cord-289152-w5ynbewh	60	17	other	other	JJ
cord-289152-w5ynbewh	60	18	viruses	virus	NNS
cord-289152-w5ynbewh	60	19	such	such	JJ
cord-289152-w5ynbewh	60	20	as	as	IN
cord-289152-w5ynbewh	60	21	swine	swine	NN
cord-289152-w5ynbewh	60	22	influenza	influenza	NN
cord-289152-w5ynbewh	60	23	virus	virus	NN
cord-289152-w5ynbewh	60	24	(	(	-LRB-
cord-289152-w5ynbewh	60	25	SIV	SIV	NNP
cord-289152-w5ynbewh	60	26	)	)	-RRB-
cord-289152-w5ynbewh	60	27	,	,	,
cord-289152-w5ynbewh	60	28	porcine	porcine	JJ
cord-289152-w5ynbewh	60	29	respiratory	respiratory	JJ
cord-289152-w5ynbewh	60	30	coronavirus	coronavirus	NN
cord-289152-w5ynbewh	60	31	(	(	-LRB-
cord-289152-w5ynbewh	60	32	PRCV	PRCV	NNP
cord-289152-w5ynbewh	60	33	)	)	-RRB-
cord-289152-w5ynbewh	60	34	,	,	,
cord-289152-w5ynbewh	60	35	transmissible	transmissible	JJ
cord-289152-w5ynbewh	60	36	gastroenteritis	gastroenteritis	NN
cord-289152-w5ynbewh	60	37	(	(	-LRB-
cord-289152-w5ynbewh	60	38	TGE	TGE	NNP
cord-289152-w5ynbewh	60	39	)	)	-RRB-
cord-289152-w5ynbewh	60	40	virus	virus	NN
cord-289152-w5ynbewh	60	41	,	,	,
cord-289152-w5ynbewh	60	42	and	and	CC
cord-289152-w5ynbewh	60	43	pseudorabies	pseudorabies	NN
cord-289152-w5ynbewh	60	44	virus	virus	NN
cord-289152-w5ynbewh	60	45	(	(	-LRB-
cord-289152-w5ynbewh	60	46	Albina	Albina	NNP
cord-289152-w5ynbewh	60	47	et	et	FW
cord-289152-w5ynbewh	60	48	al	al	NNP
cord-289152-w5ynbewh	60	49	.	.	NNP
cord-289152-w5ynbewh	60	50	,	,	,
cord-289152-w5ynbewh	60	51	1998a	1998a	CD
cord-289152-w5ynbewh	60	52	;	;	:
cord-289152-w5ynbewh	60	53	Meier	Meier	NNP
cord-289152-w5ynbewh	60	54	et	et	NNP
cord-289152-w5ynbewh	60	55	al	al	NNP
cord-289152-w5ynbewh	60	56	.	.	NNP
cord-289152-w5ynbewh	60	57	,	,	,
cord-289152-w5ynbewh	60	58	2003	2003	CD
cord-289152-w5ynbewh	60	59	;	;	:
cord-289152-w5ynbewh	60	60	Van	Van	NNP
cord-289152-w5ynbewh	60	61	Reeth	Reeth	NNP
cord-289152-w5ynbewh	60	62	and	and	CC
cord-289152-w5ynbewh	60	63	Nauwynck	Nauwynck	NNP
cord-289152-w5ynbewh	60	64	,	,	,
cord-289152-w5ynbewh	60	65	2000	2000	CD
cord-289152-w5ynbewh	60	66	;	;	:
cord-289152-w5ynbewh	60	67	Van	Van	NNP
cord-289152-w5ynbewh	60	68	Reeth	Reeth	NNP
cord-289152-w5ynbewh	60	69	et	et	NNP
cord-289152-w5ynbewh	60	70	al	al	NNP
cord-289152-w5ynbewh	60	71	.	.	NNP
cord-289152-w5ynbewh	60	72	,	,	,
cord-289152-w5ynbewh	60	73	1999	1999	CD
cord-289152-w5ynbewh	60	74	.	.	.
cord-289152-w5ynbewh	61	1	Because	because	IN
cord-289152-w5ynbewh	61	2	NF	nf	NN
cord-289152-w5ynbewh	61	3	-	-	HYPH
cord-289152-w5ynbewh	61	4	nB	nB	NNP
cord-289152-w5ynbewh	61	5	is	be	VBZ
cord-289152-w5ynbewh	61	6	important	important	JJ
cord-289152-w5ynbewh	61	7	for	for	IN
cord-289152-w5ynbewh	61	8	regulation	regulation	NN
cord-289152-w5ynbewh	61	9	of	of	IN
cord-289152-w5ynbewh	61	10	type	type	NN
cord-289152-w5ynbewh	62	1	I	-PRON-	PRP
cord-289152-w5ynbewh	62	2	IFN	IFN	NNP
cord-289152-w5ynbewh	62	3	and	and	CC
cord-289152-w5ynbewh	62	4	After	after	IN
cord-289152-w5ynbewh	62	5	48	48	CD
cord-289152-w5ynbewh	62	6	h	h	NN
cord-289152-w5ynbewh	62	7	,	,	,
cord-289152-w5ynbewh	62	8	cells	cell	NNS
cord-289152-w5ynbewh	62	9	were	be	VBD
cord-289152-w5ynbewh	62	10	fixed	fix	VBN
cord-289152-w5ynbewh	62	11	and	and	CC
cord-289152-w5ynbewh	62	12	permeabilized	permeabilize	VBN
cord-289152-w5ynbewh	62	13	followed	follow	VBN
cord-289152-w5ynbewh	62	14	by	by	IN
cord-289152-w5ynbewh	62	15	IFA	IFA	NNP
cord-289152-w5ynbewh	62	16	.	.	.
cord-289152-w5ynbewh	63	1	Nuclear	nuclear	JJ
cord-289152-w5ynbewh	63	2	translocation	translocation	NN
cord-289152-w5ynbewh	63	3	of	of	IN
cord-289152-w5ynbewh	63	4	NF	nf	NN
cord-289152-w5ynbewh	63	5	-	-	HYPH
cord-289152-w5ynbewh	63	6	nB	nB	NNP
cord-289152-w5ynbewh	63	7	was	be	VBD
cord-289152-w5ynbewh	63	8	detected	detect	VBN
cord-289152-w5ynbewh	63	9	by	by	IN
cord-289152-w5ynbewh	63	10	confocal	confocal	JJ
cord-289152-w5ynbewh	63	11	laser	laser	NN
cord-289152-w5ynbewh	63	12	microscopy	microscopy	NN
cord-289152-w5ynbewh	63	13	with	with	IN
cord-289152-w5ynbewh	63	14	FITC	FITC	NNP
cord-289152-w5ynbewh	63	15	staining	stain	VBG
cord-289152-w5ynbewh	63	16	following	follow	VBG
cord-289152-w5ynbewh	63	17	incubation	incubation	NN
cord-289152-w5ynbewh	63	18	with	with	IN
cord-289152-w5ynbewh	63	19	a	a	DT
cord-289152-w5ynbewh	63	20	specific	specific	JJ
cord-289152-w5ynbewh	63	21	antibody	antibody	NN
cord-289152-w5ynbewh	63	22	recognizing	recognize	VBG
cord-289152-w5ynbewh	63	23	the	the	DT
cord-289152-w5ynbewh	63	24	NF	nf	NN
cord-289152-w5ynbewh	63	25	-	-	HYPH
cord-289152-w5ynbewh	63	26	nB	nB	NNP
cord-289152-w5ynbewh	63	27	p65	p65	NN
cord-289152-w5ynbewh	63	28	subunit	subunit	NN
cord-289152-w5ynbewh	63	29	.	.	.
cord-289152-w5ynbewh	64	1	(	(	-LRB-
cord-289152-w5ynbewh	64	2	B	b	NN
cord-289152-w5ynbewh	64	3	)	)	-RRB-
cord-289152-w5ynbewh	64	4	Nuclear	nuclear	JJ
cord-289152-w5ynbewh	64	5	translocation	translocation	NN
cord-289152-w5ynbewh	64	6	of	of	IN
cord-289152-w5ynbewh	64	7	NF	nf	NN
cord-289152-w5ynbewh	64	8	-	-	HYPH
cord-289152-w5ynbewh	64	9	nB	nB	NNP
cord-289152-w5ynbewh	64	10	detected	detect	VBN
cord-289152-w5ynbewh	64	11	by	by	IN
cord-289152-w5ynbewh	64	12	Western	western	JJ
cord-289152-w5ynbewh	64	13	blot	blot	NN
cord-289152-w5ynbewh	64	14	of	of	IN
cord-289152-w5ynbewh	64	15	nuclear	nuclear	JJ
cord-289152-w5ynbewh	64	16	extracts	extract	NNS
cord-289152-w5ynbewh	64	17	from	from	IN
cord-289152-w5ynbewh	64	18	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	64	19	cells	cell	NNS
cord-289152-w5ynbewh	64	20	and	and	CC
cord-289152-w5ynbewh	64	21	PAM	PAM	NNP
cord-289152-w5ynbewh	64	22	cultures	culture	NNS
cord-289152-w5ynbewh	64	23	.	.	.
cord-289152-w5ynbewh	65	1	Both	both	DT
cord-289152-w5ynbewh	65	2	cell	cell	NN
cord-289152-w5ynbewh	65	3	types	type	NNS
cord-289152-w5ynbewh	65	4	were	be	VBD
cord-289152-w5ynbewh	65	5	infected	infect	VBN
cord-289152-w5ynbewh	65	6	with	with	IN
cord-289152-w5ynbewh	65	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	65	8	at	at	IN
cord-289152-w5ynbewh	65	9	MOI	MOI	NNP
cord-289152-w5ynbewh	65	10	=	=	SYM
cord-289152-w5ynbewh	65	11	0.1	0.1	CD
cord-289152-w5ynbewh	65	12	.	.	.
cord-289152-w5ynbewh	66	1	At	at	IN
cord-289152-w5ynbewh	66	2	5	5	CD
cord-289152-w5ynbewh	66	3	,	,	,
cord-289152-w5ynbewh	66	4	24	24	CD
cord-289152-w5ynbewh	66	5	,	,	,
cord-289152-w5ynbewh	66	6	36	36	CD
cord-289152-w5ynbewh	66	7	,	,	,
cord-289152-w5ynbewh	66	8	48	48	CD
cord-289152-w5ynbewh	66	9	,	,	,
cord-289152-w5ynbewh	66	10	and	and	CC
cord-289152-w5ynbewh	66	11	60	60	CD
cord-289152-w5ynbewh	66	12	(	(	-LRB-
cord-289152-w5ynbewh	66	13	only	only	RB
cord-289152-w5ynbewh	66	14	in	in	IN
cord-289152-w5ynbewh	66	15	PAM	PAM	NNP
cord-289152-w5ynbewh	66	16	)	)	-RRB-
cord-289152-w5ynbewh	67	1	h	h	LS
cord-289152-w5ynbewh	67	2	post	post	NN
cord-289152-w5ynbewh	67	3	-	-	NN
cord-289152-w5ynbewh	67	4	infection	infection	JJ
cord-289152-w5ynbewh	67	5	,	,	,
cord-289152-w5ynbewh	67	6	nuclear	nuclear	JJ
cord-289152-w5ynbewh	67	7	extracts	extract	NNS
cord-289152-w5ynbewh	67	8	were	be	VBD
cord-289152-w5ynbewh	67	9	prepared	prepare	VBN
cord-289152-w5ynbewh	67	10	and	and	CC
cord-289152-w5ynbewh	67	11	subjected	subject	VBN
cord-289152-w5ynbewh	67	12	to	to	IN
cord-289152-w5ynbewh	67	13	Western	western	JJ
cord-289152-w5ynbewh	67	14	blot	blot	NN
cord-289152-w5ynbewh	67	15	analysis	analysis	NN
cord-289152-w5ynbewh	67	16	,	,	,
cord-289152-w5ynbewh	67	17	as	as	IN
cord-289152-w5ynbewh	67	18	described	describe	VBN
cord-289152-w5ynbewh	67	19	in	in	IN
cord-289152-w5ynbewh	67	20	Materials	material	NNS
cord-289152-w5ynbewh	67	21	and	and	CC
cord-289152-w5ynbewh	67	22	methods	method	NNS
cord-289152-w5ynbewh	67	23	.	.	.
cord-289152-w5ynbewh	68	1	cytokines	cytokine	NNS
cord-289152-w5ynbewh	68	2	(	(	-LRB-
cord-289152-w5ynbewh	68	3	Lenardo	Lenardo	NNP
cord-289152-w5ynbewh	68	4	et	et	NNP
cord-289152-w5ynbewh	68	5	al	al	NNP
cord-289152-w5ynbewh	68	6	.	.	NNP
cord-289152-w5ynbewh	68	7	,	,	,
cord-289152-w5ynbewh	68	8	1989	1989	CD
cord-289152-w5ynbewh	68	9	;	;	:
cord-289152-w5ynbewh	68	10	Mogensen	Mogensen	NNP
cord-289152-w5ynbewh	68	11	and	and	CC
cord-289152-w5ynbewh	68	12	Paludan	Paludan	NNP
cord-289152-w5ynbewh	68	13	,	,	,
cord-289152-w5ynbewh	68	14	2001	2001	CD
cord-289152-w5ynbewh	68	15	)	)	-RRB-
cord-289152-w5ynbewh	68	16	,	,	,
cord-289152-w5ynbewh	68	17	we	-PRON-	PRP
cord-289152-w5ynbewh	68	18	hypothesized	hypothesize	VBD
cord-289152-w5ynbewh	68	19	that	that	IN
cord-289152-w5ynbewh	68	20	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	68	21	infection	infection	NN
cord-289152-w5ynbewh	68	22	may	may	MD
cord-289152-w5ynbewh	68	23	inhibit	inhibit	VB
cord-289152-w5ynbewh	68	24	NF	nf	NN
cord-289152-w5ynbewh	68	25	-	-	HYPH
cord-289152-w5ynbewh	68	26	nB	nB	NNP
cord-289152-w5ynbewh	68	27	activation	activation	NN
cord-289152-w5ynbewh	68	28	to	to	TO
cord-289152-w5ynbewh	68	29	prevent	prevent	VB
cord-289152-w5ynbewh	68	30	antiviral	antiviral	JJ
cord-289152-w5ynbewh	68	31	responses	response	NNS
cord-289152-w5ynbewh	68	32	.	.	.
cord-289152-w5ynbewh	69	1	The	the	DT
cord-289152-w5ynbewh	69	2	experiments	experiment	NNS
cord-289152-w5ynbewh	69	3	presented	present	VBN
cord-289152-w5ynbewh	69	4	herein	herein	RB
cord-289152-w5ynbewh	69	5	were	be	VBD
cord-289152-w5ynbewh	69	6	designed	design	VBN
cord-289152-w5ynbewh	69	7	to	to	TO
cord-289152-w5ynbewh	69	8	determine	determine	VB
cord-289152-w5ynbewh	69	9	if	if	IN
cord-289152-w5ynbewh	69	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	69	11	infection	infection	NN
cord-289152-w5ynbewh	69	12	modulates	modulate	VBZ
cord-289152-w5ynbewh	69	13	NF	NF	NNP
cord-289152-w5ynbewh	69	14	-	-	HYPH
cord-289152-w5ynbewh	69	15	nB	nB	NNP
cord-289152-w5ynbewh	69	16	activation	activation	NN
cord-289152-w5ynbewh	69	17	in	in	IN
cord-289152-w5ynbewh	69	18	host	host	NN
cord-289152-w5ynbewh	69	19	cells	cell	NNS
cord-289152-w5ynbewh	69	20	.	.	.
cord-289152-w5ynbewh	70	1	After	after	IN
cord-289152-w5ynbewh	70	2	observing	observe	VBG
cord-289152-w5ynbewh	70	3	NF	nf	NN
cord-289152-w5ynbewh	70	4	-	-	HYPH
cord-289152-w5ynbewh	70	5	nB	nB	NNP
cord-289152-w5ynbewh	70	6	activation	activation	NN
cord-289152-w5ynbewh	70	7	following	follow	VBG
cord-289152-w5ynbewh	70	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	70	9	infection	infection	NN
cord-289152-w5ynbewh	70	10	,	,	,
cord-289152-w5ynbewh	70	11	the	the	DT
cord-289152-w5ynbewh	70	12	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	70	13	by	by	IN
cord-289152-w5ynbewh	70	14	which	which	WDT
cord-289152-w5ynbewh	70	15	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	70	16	mediates	mediate	VBZ
cord-289152-w5ynbewh	70	17	NF	NF	NNP
cord-289152-w5ynbewh	70	18	-	-	HYPH
cord-289152-w5ynbewh	70	19	nB	nB	NNP
cord-289152-w5ynbewh	70	20	activation	activation	NN
cord-289152-w5ynbewh	70	21	,	,	,
cord-289152-w5ynbewh	70	22	as	as	RB
cord-289152-w5ynbewh	70	23	well	well	RB
cord-289152-w5ynbewh	70	24	as	as	IN
cord-289152-w5ynbewh	70	25	the	the	DT
cord-289152-w5ynbewh	70	26	role	role	NN
cord-289152-w5ynbewh	70	27	of	of	IN
cord-289152-w5ynbewh	70	28	NF	nf	NN
cord-289152-w5ynbewh	70	29	-	-	HYPH
cord-289152-w5ynbewh	70	30	nB	nB	NNP
cord-289152-w5ynbewh	70	31	activation	activation	NN
cord-289152-w5ynbewh	70	32	in	in	IN
cord-289152-w5ynbewh	70	33	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	70	34	replication	replication	NN
cord-289152-w5ynbewh	70	35	,	,	,
cord-289152-w5ynbewh	70	36	were	be	VBD
cord-289152-w5ynbewh	70	37	studied	study	VBN
cord-289152-w5ynbewh	70	38	using	use	VBG
cord-289152-w5ynbewh	70	39	a	a	DT
cord-289152-w5ynbewh	70	40	dominant	dominant	JJ
cord-289152-w5ynbewh	70	41	negative	negative	JJ
cord-289152-w5ynbewh	70	42	form	form	NN
cord-289152-w5ynbewh	70	43	of	of	IN
cord-289152-w5ynbewh	70	44	InBa	InBa	NNP
cord-289152-w5ynbewh	70	45	.	.	.
cord-289152-w5ynbewh	71	1	The	the	DT
cord-289152-w5ynbewh	71	2	present	present	JJ
cord-289152-w5ynbewh	71	3	study	study	NN
cord-289152-w5ynbewh	71	4	provides	provide	VBZ
cord-289152-w5ynbewh	71	5	a	a	DT
cord-289152-w5ynbewh	71	6	basis	basis	NN
cord-289152-w5ynbewh	71	7	for	for	IN
cord-289152-w5ynbewh	71	8	understanding	understand	VBG
cord-289152-w5ynbewh	71	9	the	the	DT
cord-289152-w5ynbewh	71	10	molecular	molecular	JJ
cord-289152-w5ynbewh	71	11	pathways	pathway	NNS
cord-289152-w5ynbewh	71	12	of	of	IN
cord-289152-w5ynbewh	71	13	pathology	pathology	NN
cord-289152-w5ynbewh	71	14	and	and	CC
cord-289152-w5ynbewh	71	15	immune	immune	JJ
cord-289152-w5ynbewh	71	16	evasion	evasion	NN
cord-289152-w5ynbewh	71	17	associated	associate	VBN
cord-289152-w5ynbewh	71	18	with	with	IN
cord-289152-w5ynbewh	71	19	disease	disease	NN
cord-289152-w5ynbewh	71	20	caused	cause	VBN
cord-289152-w5ynbewh	71	21	by	by	IN
cord-289152-w5ynbewh	71	22	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	71	23	.	.	.
cord-289152-w5ynbewh	72	1	Nuclear	nuclear	JJ
cord-289152-w5ynbewh	72	2	translocation	translocation	NN
cord-289152-w5ynbewh	72	3	,	,	,
cord-289152-w5ynbewh	72	4	which	which	WDT
cord-289152-w5ynbewh	72	5	is	be	VBZ
cord-289152-w5ynbewh	72	6	one	one	CD
cord-289152-w5ynbewh	72	7	of	of	IN
cord-289152-w5ynbewh	72	8	the	the	DT
cord-289152-w5ynbewh	72	9	key	key	JJ
cord-289152-w5ynbewh	72	10	steps	step	NNS
cord-289152-w5ynbewh	72	11	during	during	IN
cord-289152-w5ynbewh	72	12	activation	activation	NN
cord-289152-w5ynbewh	72	13	of	of	IN
cord-289152-w5ynbewh	72	14	NF	nf	NN
cord-289152-w5ynbewh	72	15	-	-	HYPH
cord-289152-w5ynbewh	72	16	nB	nB	NNP
cord-289152-w5ynbewh	72	17	,	,	,
cord-289152-w5ynbewh	72	18	was	be	VBD
cord-289152-w5ynbewh	72	19	detected	detect	VBN
cord-289152-w5ynbewh	72	20	by	by	IN
cord-289152-w5ynbewh	72	21	indirect	indirect	JJ
cord-289152-w5ynbewh	72	22	fluorescent	fluorescent	JJ
cord-289152-w5ynbewh	72	23	antibody	antibody	NN
cord-289152-w5ynbewh	72	24	(	(	-LRB-
cord-289152-w5ynbewh	72	25	IFA	IFA	NNP
cord-289152-w5ynbewh	72	26	)	)	-RRB-
cord-289152-w5ynbewh	72	27	staining	stain	VBG
cord-289152-w5ynbewh	72	28	following	follow	VBG
cord-289152-w5ynbewh	72	29	infection	infection	NN
cord-289152-w5ynbewh	72	30	with	with	IN
cord-289152-w5ynbewh	72	31	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	72	32	(	(	-LRB-
cord-289152-w5ynbewh	72	33	Fig	Fig	NNP
cord-289152-w5ynbewh	72	34	.	.	.
cord-289152-w5ynbewh	72	35	1A	1a	NN
cord-289152-w5ynbewh	72	36	)	)	-RRB-
cord-289152-w5ynbewh	72	37	.	.	.
cord-289152-w5ynbewh	73	1	In	in	IN
cord-289152-w5ynbewh	73	2	uninfected	uninfected	JJ
cord-289152-w5ynbewh	73	3	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	73	4	cells	cell	NNS
cord-289152-w5ynbewh	73	5	,	,	,
cord-289152-w5ynbewh	73	6	p65	p65	NN
cord-289152-w5ynbewh	73	7	staining	staining	NN
cord-289152-w5ynbewh	73	8	was	be	VBD
cord-289152-w5ynbewh	73	9	predominantly	predominantly	RB
cord-289152-w5ynbewh	73	10	cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	73	11	,	,	,
cord-289152-w5ynbewh	73	12	whereas	whereas	IN
cord-289152-w5ynbewh	73	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	73	14	infection	infection	NN
cord-289152-w5ynbewh	73	15	(	(	-LRB-
cord-289152-w5ynbewh	73	16	multiplicity	multiplicity	NN
cord-289152-w5ynbewh	73	17	of	of	IN
cord-289152-w5ynbewh	73	18	infection	infection	NN
cord-289152-w5ynbewh	73	19	(	(	-LRB-
cord-289152-w5ynbewh	73	20	MOI	MOI	NNP
cord-289152-w5ynbewh	73	21	)	)	-RRB-
cord-289152-w5ynbewh	73	22	=	=	SYM
cord-289152-w5ynbewh	73	23	0.1	0.1	CD
cord-289152-w5ynbewh	73	24	)	)	-RRB-
cord-289152-w5ynbewh	73	25	for	for	IN
cord-289152-w5ynbewh	73	26	48	48	CD
cord-289152-w5ynbewh	73	27	h	h	NN
cord-289152-w5ynbewh	73	28	resulted	result	VBD
cord-289152-w5ynbewh	73	29	in	in	IN
cord-289152-w5ynbewh	73	30	nuclear	nuclear	JJ
cord-289152-w5ynbewh	73	31	localization	localization	NN
cord-289152-w5ynbewh	73	32	of	of	IN
cord-289152-w5ynbewh	73	33	NF	nf	NN
cord-289152-w5ynbewh	73	34	-	-	:
cord-289152-w5ynbewh	73	35	nB	nb	NN
cord-289152-w5ynbewh	73	36	p65	p65	NN
cord-289152-w5ynbewh	73	37	staining	stain	VBG
cord-289152-w5ynbewh	73	38	and	and	CC
cord-289152-w5ynbewh	73	39	increased	increase	VBN
cord-289152-w5ynbewh	73	40	cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	73	41	staining	staining	NN
cord-289152-w5ynbewh	73	42	of	of	IN
cord-289152-w5ynbewh	73	43	NF	nf	NN
cord-289152-w5ynbewh	73	44	-	-	HYPH
cord-289152-w5ynbewh	73	45	nB	nB	NNP
cord-289152-w5ynbewh	73	46	p65	p65	ADD
cord-289152-w5ynbewh	73	47	.	.	.
cord-289152-w5ynbewh	74	1	In	in	IN
cord-289152-w5ynbewh	74	2	Fig	Fig	NNP
cord-289152-w5ynbewh	74	3	.	.	.
cord-289152-w5ynbewh	75	1	1B	1b	LS
cord-289152-w5ynbewh	75	2	,	,	,
cord-289152-w5ynbewh	75	3	Western	western	JJ
cord-289152-w5ynbewh	75	4	blot	blot	NN
cord-289152-w5ynbewh	75	5	analysis	analysis	NN
cord-289152-w5ynbewh	75	6	shows	show	VBZ
cord-289152-w5ynbewh	75	7	that	that	IN
cord-289152-w5ynbewh	75	8	infection	infection	NN
cord-289152-w5ynbewh	75	9	with	with	IN
cord-289152-w5ynbewh	75	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	75	11	led	lead	VBD
cord-289152-w5ynbewh	75	12	to	to	IN
cord-289152-w5ynbewh	75	13	accumulation	accumulation	NN
cord-289152-w5ynbewh	75	14	of	of	IN
cord-289152-w5ynbewh	75	15	NF	nf	NN
cord-289152-w5ynbewh	75	16	-	-	HYPH
cord-289152-w5ynbewh	75	17	nB	nB	NNP
cord-289152-w5ynbewh	75	18	protein	protein	NN
cord-289152-w5ynbewh	75	19	in	in	IN
cord-289152-w5ynbewh	75	20	the	the	DT
cord-289152-w5ynbewh	75	21	nucleus	nucleus	NN
cord-289152-w5ynbewh	75	22	.	.	.
cord-289152-w5ynbewh	76	1	Compared	compare	VBN
cord-289152-w5ynbewh	76	2	to	to	IN
cord-289152-w5ynbewh	76	3	uninfected	uninfected	JJ
cord-289152-w5ynbewh	76	4	control	control	NN
cord-289152-w5ynbewh	76	5	cells	cell	NNS
cord-289152-w5ynbewh	76	6	,	,	,
cord-289152-w5ynbewh	76	7	the	the	DT
cord-289152-w5ynbewh	76	8	amount	amount	NN
cord-289152-w5ynbewh	76	9	of	of	IN
cord-289152-w5ynbewh	76	10	NF	nf	NN
cord-289152-w5ynbewh	76	11	-	-	HYPH
cord-289152-w5ynbewh	76	12	nB	nB	NNP
cord-289152-w5ynbewh	76	13	increased	increase	VBD
cord-289152-w5ynbewh	76	14	as	as	IN
cord-289152-w5ynbewh	76	15	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	76	16	infection	infection	NN
cord-289152-w5ynbewh	76	17	progressed	progress	VBD
cord-289152-w5ynbewh	76	18	in	in	IN
cord-289152-w5ynbewh	76	19	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	76	20	cells	cell	NNS
cord-289152-w5ynbewh	76	21	and	and	CC
cord-289152-w5ynbewh	76	22	PAM	PAM	NNP
cord-289152-w5ynbewh	76	23	cultures	culture	NNS
cord-289152-w5ynbewh	76	24	.	.	.
cord-289152-w5ynbewh	77	1	Increased	increase	VBN
cord-289152-w5ynbewh	77	2	NF	nf	NN
cord-289152-w5ynbewh	77	3	-	-	HYPH
cord-289152-w5ynbewh	77	4	nB	nB	NNP
cord-289152-w5ynbewh	77	5	concentrations	concentration	NNS
cord-289152-w5ynbewh	77	6	in	in	IN
cord-289152-w5ynbewh	77	7	the	the	DT
cord-289152-w5ynbewh	77	8	nucleus	nucleus	NN
cord-289152-w5ynbewh	77	9	were	be	VBD
cord-289152-w5ynbewh	77	10	apparent	apparent	JJ
cord-289152-w5ynbewh	77	11	at	at	IN
cord-289152-w5ynbewh	77	12	24	24	CD
cord-289152-w5ynbewh	77	13	h	h	NN
cord-289152-w5ynbewh	77	14	p.i	p.i	NNP
cord-289152-w5ynbewh	77	15	.	.	.
cord-289152-w5ynbewh	78	1	in	in	IN
cord-289152-w5ynbewh	78	2	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	78	3	cells	cell	NNS
cord-289152-w5ynbewh	78	4	and	and	CC
cord-289152-w5ynbewh	78	5	at	at	IN
cord-289152-w5ynbewh	78	6	36	36	CD
cord-289152-w5ynbewh	78	7	h	h	NN
cord-289152-w5ynbewh	78	8	p.i	p.i	NNP
cord-289152-w5ynbewh	78	9	.	.	NNP
cord-289152-w5ynbewh	78	10	in	in	IN
cord-289152-w5ynbewh	78	11	PAM	PAM	NNP
cord-289152-w5ynbewh	78	12	cultures	culture	NNS
cord-289152-w5ynbewh	78	13	.	.	.
cord-289152-w5ynbewh	79	1	In	in	IN
cord-289152-w5ynbewh	79	2	these	these	DT
cord-289152-w5ynbewh	79	3	(	(	-LRB-
cord-289152-w5ynbewh	79	4	and	and	CC
cord-289152-w5ynbewh	79	5	subsequent	subsequent	JJ
cord-289152-w5ynbewh	79	6	)	)	-RRB-
cord-289152-w5ynbewh	79	7	experiments	experiment	NNS
cord-289152-w5ynbewh	79	8	,	,	,
cord-289152-w5ynbewh	79	9	cell	cell	NN
cord-289152-w5ynbewh	79	10	viability	viability	NN
cord-289152-w5ynbewh	79	11	was	be	VBD
cord-289152-w5ynbewh	79	12	assessed	assess	VBN
cord-289152-w5ynbewh	79	13	by	by	IN
cord-289152-w5ynbewh	79	14	trypan	trypan	NNP
cord-289152-w5ynbewh	79	15	blue	blue	JJ
cord-289152-w5ynbewh	79	16	staining	staining	NN
cord-289152-w5ynbewh	79	17	,	,	,
cord-289152-w5ynbewh	79	18	and	and	CC
cord-289152-w5ynbewh	79	19	cultures	culture	NNS
cord-289152-w5ynbewh	79	20	were	be	VBD
cord-289152-w5ynbewh	79	21	consistently	consistently	RB
cord-289152-w5ynbewh	79	22	found	find	VBN
cord-289152-w5ynbewh	79	23	to	to	TO
cord-289152-w5ynbewh	79	24	be	be	VB
cord-289152-w5ynbewh	79	25	approximately	approximately	RB
cord-289152-w5ynbewh	79	26	96	96	CD
cord-289152-w5ynbewh	79	27	%	%	NN
cord-289152-w5ynbewh	79	28	viable	viable	JJ
cord-289152-w5ynbewh	79	29	in	in	IN
cord-289152-w5ynbewh	79	30	mock	mock	NN
cord-289152-w5ynbewh	79	31	-	-	HYPH
cord-289152-w5ynbewh	79	32	infected	infect	VBN
cord-289152-w5ynbewh	79	33	cells	cell	NNS
cord-289152-w5ynbewh	79	34	and	and	CC
cord-289152-w5ynbewh	79	35	92	92	CD
cord-289152-w5ynbewh	79	36	%	%	NN
cord-289152-w5ynbewh	79	37	in	in	IN
cord-289152-w5ynbewh	79	38	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	79	39	-	-	HYPH
cord-289152-w5ynbewh	79	40	infected	infect	VBN
cord-289152-w5ynbewh	79	41	cells	cell	NNS
cord-289152-w5ynbewh	79	42	at	at	IN
cord-289152-w5ynbewh	79	43	48	48	CD
cord-289152-w5ynbewh	79	44	h	h	NN
cord-289152-w5ynbewh	79	45	p.i	p.i	NNP
cord-289152-w5ynbewh	79	46	.	.	.
cord-289152-w5ynbewh	80	1	To	to	TO
cord-289152-w5ynbewh	80	2	determine	determine	VB
cord-289152-w5ynbewh	80	3	if	if	IN
cord-289152-w5ynbewh	80	4	nuclear	nuclear	JJ
cord-289152-w5ynbewh	80	5	translocated	translocate	VBN
cord-289152-w5ynbewh	80	6	NF	nf	NN
cord-289152-w5ynbewh	80	7	-	-	HYPH
cord-289152-w5ynbewh	80	8	nB	nB	NNP
cord-289152-w5ynbewh	80	9	was	be	VBD
cord-289152-w5ynbewh	80	10	capable	capable	JJ
cord-289152-w5ynbewh	80	11	of	of	IN
cord-289152-w5ynbewh	80	12	binding	bind	VBG
cord-289152-w5ynbewh	80	13	nB	nb	DT
cord-289152-w5ynbewh	80	14	binding	bind	VBG
cord-289152-w5ynbewh	80	15	motifs	motif	NNS
cord-289152-w5ynbewh	80	16	following	follow	VBG
cord-289152-w5ynbewh	80	17	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	80	18	infection	infection	NN
cord-289152-w5ynbewh	80	19	,	,	,
cord-289152-w5ynbewh	80	20	an	an	DT
cord-289152-w5ynbewh	80	21	NF	nf	NN
cord-289152-w5ynbewh	80	22	-	-	HYPH
cord-289152-w5ynbewh	80	23	nB	nB	NNP
cord-289152-w5ynbewh	80	24	p65	p65	NN
cord-289152-w5ynbewh	80	25	transcription	transcription	NN
cord-289152-w5ynbewh	80	26	factor	factor	NN
cord-289152-w5ynbewh	80	27	assay	assay	NN
cord-289152-w5ynbewh	80	28	was	be	VBD
cord-289152-w5ynbewh	80	29	performed	perform	VBN
cord-289152-w5ynbewh	80	30	using	use	VBG
cord-289152-w5ynbewh	80	31	nuclear	nuclear	JJ
cord-289152-w5ynbewh	80	32	extracts	extract	NNS
cord-289152-w5ynbewh	80	33	of	of	IN
cord-289152-w5ynbewh	80	34	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	80	35	cells	cell	NNS
cord-289152-w5ynbewh	80	36	and	and	CC
cord-289152-w5ynbewh	80	37	PAM	PAM	NNP
cord-289152-w5ynbewh	80	38	cultures	culture	NNS
cord-289152-w5ynbewh	80	39	infected	infect	VBN
cord-289152-w5ynbewh	80	40	with	with	IN
cord-289152-w5ynbewh	80	41	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	80	42	.	.	.
cord-289152-w5ynbewh	81	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	81	2	cells	cell	NNS
cord-289152-w5ynbewh	81	3	and	and	CC
cord-289152-w5ynbewh	81	4	PAM	PAM	NNP
cord-289152-w5ynbewh	81	5	cultures	culture	NNS
cord-289152-w5ynbewh	81	6	were	be	VBD
cord-289152-w5ynbewh	81	7	either	either	DT
cord-289152-w5ynbewh	81	8	mock	mock	NN
cord-289152-w5ynbewh	81	9	-	-	HYPH
cord-289152-w5ynbewh	81	10	infected	infect	VBN
cord-289152-w5ynbewh	81	11	or	or	CC
cord-289152-w5ynbewh	81	12	infected	infect	VBN
cord-289152-w5ynbewh	81	13	with	with	IN
cord-289152-w5ynbewh	81	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	81	15	at	at	IN
cord-289152-w5ynbewh	81	16	MOI	MOI	NNP
cord-289152-w5ynbewh	81	17	=	=	SYM
cord-289152-w5ynbewh	81	18	0.1	0.1	CD
cord-289152-w5ynbewh	81	19	,	,	,
cord-289152-w5ynbewh	81	20	and	and	CC
cord-289152-w5ynbewh	81	21	nuclear	nuclear	JJ
cord-289152-w5ynbewh	81	22	extracts	extract	NNS
cord-289152-w5ynbewh	81	23	were	be	VBD
cord-289152-w5ynbewh	81	24	prepared	prepare	VBN
cord-289152-w5ynbewh	81	25	at	at	IN
cord-289152-w5ynbewh	81	26	the	the	DT
cord-289152-w5ynbewh	81	27	indicated	indicate	VBN
cord-289152-w5ynbewh	81	28	times	time	NNS
cord-289152-w5ynbewh	81	29	after	after	IN
cord-289152-w5ynbewh	81	30	virus	virus	NN
cord-289152-w5ynbewh	81	31	infection	infection	NN
cord-289152-w5ynbewh	81	32	.	.	.
cord-289152-w5ynbewh	82	1	Following	follow	VBG
cord-289152-w5ynbewh	82	2	infection	infection	NN
cord-289152-w5ynbewh	82	3	with	with	IN
cord-289152-w5ynbewh	82	4	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	82	5	,	,	,
cord-289152-w5ynbewh	82	6	NF	NF	NNP
cord-289152-w5ynbewh	82	7	-	-	HYPH
cord-289152-w5ynbewh	82	8	nB	nB	NNP
cord-289152-w5ynbewh	82	9	p65	p65	NN
cord-289152-w5ynbewh	82	10	DNA	dna	NN
cord-289152-w5ynbewh	82	11	binding	binding	NN
cord-289152-w5ynbewh	82	12	activity	activity	NN
cord-289152-w5ynbewh	82	13	increased	increase	VBD
cord-289152-w5ynbewh	82	14	as	as	IN
cord-289152-w5ynbewh	82	15	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	82	16	infection	infection	NN
cord-289152-w5ynbewh	82	17	progressed	progress	VBD
cord-289152-w5ynbewh	82	18	.	.	.
cord-289152-w5ynbewh	83	1	Although	although	IN
cord-289152-w5ynbewh	83	2	a	a	DT
cord-289152-w5ynbewh	83	3	slight	slight	NN
cord-289152-w5ynbewh	83	4	,	,	,
cord-289152-w5ynbewh	83	5	though	though	IN
cord-289152-w5ynbewh	83	6	statistically	statistically	RB
cord-289152-w5ynbewh	83	7	significant	significant	JJ
cord-289152-w5ynbewh	83	8	decrease	decrease	NN
cord-289152-w5ynbewh	83	9	was	be	VBD
cord-289152-w5ynbewh	83	10	consistently	consistently	RB
cord-289152-w5ynbewh	83	11	observed	observe	VBN
cord-289152-w5ynbewh	83	12	at	at	IN
cord-289152-w5ynbewh	83	13	24	24	CD
cord-289152-w5ynbewh	83	14	h	h	NN
cord-289152-w5ynbewh	83	15	p.i	p.i	NNP
cord-289152-w5ynbewh	83	16	.	.	NNP
cord-289152-w5ynbewh	83	17	in	in	IN
cord-289152-w5ynbewh	83	18	PAM	PAM	NNP
cord-289152-w5ynbewh	83	19	cultures	culture	NNS
cord-289152-w5ynbewh	83	20	(	(	-LRB-
cord-289152-w5ynbewh	83	21	but	but	CC
cord-289152-w5ynbewh	83	22	not	not	RB
cord-289152-w5ynbewh	83	23	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	83	24	cells	cell	NNS
cord-289152-w5ynbewh	83	25	)	)	-RRB-
cord-289152-w5ynbewh	83	26	,	,	,
cord-289152-w5ynbewh	83	27	the	the	DT
cord-289152-w5ynbewh	83	28	predominant	predominant	JJ
cord-289152-w5ynbewh	83	29	effect	effect	NN
cord-289152-w5ynbewh	83	30	of	of	IN
cord-289152-w5ynbewh	83	31	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	83	32	infection	infection	NN
cord-289152-w5ynbewh	83	33	in	in	IN
cord-289152-w5ynbewh	83	34	both	both	DT
cord-289152-w5ynbewh	83	35	cell	cell	NN
cord-289152-w5ynbewh	83	36	types	type	NNS
cord-289152-w5ynbewh	83	37	was	be	VBD
cord-289152-w5ynbewh	83	38	an	an	DT
cord-289152-w5ynbewh	83	39	increase	increase	NN
cord-289152-w5ynbewh	83	40	in	in	IN
cord-289152-w5ynbewh	83	41	NF	nf	NN
cord-289152-w5ynbewh	83	42	-	-	HYPH
cord-289152-w5ynbewh	83	43	nB	nb	NN
cord-289152-w5ynbewh	83	44	DNA	dna	NN
cord-289152-w5ynbewh	83	45	binding	binding	NN
cord-289152-w5ynbewh	83	46	activity	activity	NN
cord-289152-w5ynbewh	83	47	.	.	.
cord-289152-w5ynbewh	84	1	As	as	IN
cord-289152-w5ynbewh	84	2	shown	show	VBN
cord-289152-w5ynbewh	84	3	in	in	IN
cord-289152-w5ynbewh	84	4	Fig	Fig	NNP
cord-289152-w5ynbewh	84	5	.	.	NNP
cord-289152-w5ynbewh	84	6	2	2	CD
cord-289152-w5ynbewh	84	7	,	,	,
cord-289152-w5ynbewh	84	8	significant	significant	JJ
cord-289152-w5ynbewh	84	9	increases	increase	NNS
cord-289152-w5ynbewh	84	10	in	in	IN
cord-289152-w5ynbewh	84	11	NF	nf	NN
cord-289152-w5ynbewh	84	12	-	-	HYPH
cord-289152-w5ynbewh	84	13	nB	nb	NN
cord-289152-w5ynbewh	84	14	DNA	dna	NN
cord-289152-w5ynbewh	84	15	binding	binding	NN
cord-289152-w5ynbewh	84	16	activity	activity	NN
cord-289152-w5ynbewh	84	17	in	in	IN
cord-289152-w5ynbewh	84	18	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	84	19	-	-	HYPH
cord-289152-w5ynbewh	84	20	infected	infect	VBN
cord-289152-w5ynbewh	84	21	cells	cell	NNS
cord-289152-w5ynbewh	84	22	were	be	VBD
cord-289152-w5ynbewh	84	23	measured	measure	VBN
cord-289152-w5ynbewh	84	24	,	,	,
cord-289152-w5ynbewh	84	25	especially	especially	RB
cord-289152-w5ynbewh	84	26	at	at	IN
cord-289152-w5ynbewh	84	27	36	36	CD
cord-289152-w5ynbewh	84	28	and	and	CC
cord-289152-w5ynbewh	84	29	48	48	CD
cord-289152-w5ynbewh	84	30	h	h	NN
cord-289152-w5ynbewh	84	31	p.i	p.i	NNP
cord-289152-w5ynbewh	84	32	,	,	,
cord-289152-w5ynbewh	84	33	compared	compare	VBN
cord-289152-w5ynbewh	84	34	with	with	IN
cord-289152-w5ynbewh	84	35	that	that	DT
cord-289152-w5ynbewh	84	36	in	in	IN
cord-289152-w5ynbewh	84	37	mock	mock	JJ
cord-289152-w5ynbewh	84	38	-	-	HYPH
cord-289152-w5ynbewh	84	39	infected	infect	VBN
cord-289152-w5ynbewh	84	40	cells	cell	NNS
cord-289152-w5ynbewh	84	41	.	.	.
cord-289152-w5ynbewh	85	1	At	at	IN
cord-289152-w5ynbewh	85	2	48	48	CD
cord-289152-w5ynbewh	85	3	h	h	NN
cord-289152-w5ynbewh	85	4	p.i	p.i	NNP
cord-289152-w5ynbewh	85	5	.	.	NNP
cord-289152-w5ynbewh	85	6	,	,	,
cord-289152-w5ynbewh	85	7	NF	NF	NNP
cord-289152-w5ynbewh	85	8	-	-	HYPH
cord-289152-w5ynbewh	85	9	nB	nB	NNP
cord-289152-w5ynbewh	85	10	p65	p65	NN
cord-289152-w5ynbewh	85	11	DNA	dna	NN
cord-289152-w5ynbewh	85	12	binding	binding	NN
cord-289152-w5ynbewh	85	13	activities	activity	NNS
cord-289152-w5ynbewh	85	14	increased	increase	VBD
cord-289152-w5ynbewh	85	15	5.7-fold	5.7-fold	CD
cord-289152-w5ynbewh	85	16	in	in	IN
cord-289152-w5ynbewh	85	17	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	85	18	cells	cell	NNS
cord-289152-w5ynbewh	85	19	and	and	CC
cord-289152-w5ynbewh	85	20	2.2-fold	2.2-fold	CD
cord-289152-w5ynbewh	85	21	in	in	IN
cord-289152-w5ynbewh	85	22	PAM	PAM	NNP
cord-289152-w5ynbewh	85	23	cultures	culture	NNS
cord-289152-w5ynbewh	85	24	.	.	.
cord-289152-w5ynbewh	86	1	The	the	DT
cord-289152-w5ynbewh	86	2	NF	nf	NN
cord-289152-w5ynbewh	86	3	-	-	HYPH
cord-289152-w5ynbewh	86	4	nB	nb	NN
cord-289152-w5ynbewh	86	5	DNA	dna	NN
cord-289152-w5ynbewh	86	6	binding	binding	NN
cord-289152-w5ynbewh	86	7	activity	activity	NN
cord-289152-w5ynbewh	86	8	observed	observe	VBN
cord-289152-w5ynbewh	86	9	in	in	IN
cord-289152-w5ynbewh	86	10	these	these	DT
cord-289152-w5ynbewh	86	11	assays	assay	NNS
cord-289152-w5ynbewh	86	12	was	be	VBD
cord-289152-w5ynbewh	86	13	ablated	ablate	VBN
cord-289152-w5ynbewh	86	14	by	by	IN
cord-289152-w5ynbewh	86	15	an	an	DT
cord-289152-w5ynbewh	86	16	excess	excess	NN
cord-289152-w5ynbewh	86	17	of	of	IN
cord-289152-w5ynbewh	86	18	unlabeled	unlabeled	JJ
cord-289152-w5ynbewh	86	19	competitor	competitor	NN
cord-289152-w5ynbewh	86	20	,	,	,
cord-289152-w5ynbewh	86	21	but	but	CC
cord-289152-w5ynbewh	86	22	not	not	RB
cord-289152-w5ynbewh	86	23	by	by	IN
cord-289152-w5ynbewh	86	24	an	an	DT
cord-289152-w5ynbewh	86	25	excess	excess	NN
cord-289152-w5ynbewh	86	26	of	of	IN
cord-289152-w5ynbewh	86	27	unlabeled	unlabeled	JJ
cord-289152-w5ynbewh	86	28	noncompetitor	noncompetitor	NN
cord-289152-w5ynbewh	86	29	(	(	-LRB-
cord-289152-w5ynbewh	86	30	data	datum	NNS
cord-289152-w5ynbewh	86	31	not	not	RB
cord-289152-w5ynbewh	86	32	shown	show	VBN
cord-289152-w5ynbewh	86	33	)	)	-RRB-
cord-289152-w5ynbewh	86	34	.	.	.
cord-289152-w5ynbewh	87	1	Taken	take	VBN
cord-289152-w5ynbewh	87	2	together	together	RB
cord-289152-w5ynbewh	87	3	,	,	,
cord-289152-w5ynbewh	87	4	these	these	DT
cord-289152-w5ynbewh	87	5	results	result	NNS
cord-289152-w5ynbewh	87	6	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	87	7	that	that	IN
cord-289152-w5ynbewh	87	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	87	9	induces	induce	VBZ
cord-289152-w5ynbewh	87	10	nuclear	nuclear	JJ
cord-289152-w5ynbewh	87	11	translocation	translocation	NN
cord-289152-w5ynbewh	87	12	of	of	IN
cord-289152-w5ynbewh	87	13	NF	nf	NN
cord-289152-w5ynbewh	87	14	-	-	HYPH
cord-289152-w5ynbewh	87	15	nB	nB	NNP
cord-289152-w5ynbewh	87	16	followed	follow	VBN
cord-289152-w5ynbewh	87	17	by	by	IN
cord-289152-w5ynbewh	87	18	increased	increase	VBN
cord-289152-w5ynbewh	87	19	DNA	dna	NN
cord-289152-w5ynbewh	87	20	binding	binding	NN
cord-289152-w5ynbewh	87	21	activity	activity	NN
cord-289152-w5ynbewh	87	22	of	of	IN
cord-289152-w5ynbewh	87	23	NF	nf	NN
cord-289152-w5ynbewh	87	24	-	-	:
cord-289152-w5ynbewh	87	25	nB	nb	NN
cord-289152-w5ynbewh	87	26	both	both	DT
cord-289152-w5ynbewh	87	27	in	in	IN
cord-289152-w5ynbewh	87	28	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	87	29	cells	cell	NNS
cord-289152-w5ynbewh	87	30	and	and	CC
cord-289152-w5ynbewh	87	31	PAM	PAM	NNP
cord-289152-w5ynbewh	87	32	cultures	culture	NNS
cord-289152-w5ynbewh	87	33	.	.	.
cord-289152-w5ynbewh	88	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	88	2	enhances	enhance	VBZ
cord-289152-w5ynbewh	88	3	NF	nf	NN
cord-289152-w5ynbewh	88	4	-	-	HYPH
cord-289152-w5ynbewh	88	5	jB	jb	NN
cord-289152-w5ynbewh	88	6	-	-	HYPH
cord-289152-w5ynbewh	88	7	regulated	regulate	VBN
cord-289152-w5ynbewh	88	8	gene	gene	NN
cord-289152-w5ynbewh	88	9	expression	expression	NN
cord-289152-w5ynbewh	88	10	,	,	,
cord-289152-w5ynbewh	88	11	and	and	CC
cord-289152-w5ynbewh	89	1	NF	NF	NNP
cord-289152-w5ynbewh	89	2	-	-	HYPH
cord-289152-w5ynbewh	89	3	jB	jb	NN
cord-289152-w5ynbewh	89	4	activation	activation	NN
cord-289152-w5ynbewh	89	5	by	by	IN
cord-289152-w5ynbewh	89	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	89	7	is	be	VBZ
cord-289152-w5ynbewh	89	8	dependent	dependent	JJ
cord-289152-w5ynbewh	89	9	on	on	IN
cord-289152-w5ynbewh	89	10	viral	viral	JJ
cord-289152-w5ynbewh	89	11	dose	dose	NN
cord-289152-w5ynbewh	89	12	and	and	CC
cord-289152-w5ynbewh	89	13	active	active	JJ
cord-289152-w5ynbewh	89	14	viral	viral	JJ
cord-289152-w5ynbewh	89	15	replication	replication	NN
cord-289152-w5ynbewh	89	16	Translocation	translocation	NN
cord-289152-w5ynbewh	89	17	into	into	IN
cord-289152-w5ynbewh	89	18	the	the	DT
cord-289152-w5ynbewh	89	19	nucleus	nucleus	NN
cord-289152-w5ynbewh	89	20	allows	allow	VBZ
cord-289152-w5ynbewh	89	21	NF	NF	NNP
cord-289152-w5ynbewh	89	22	-	-	HYPH
cord-289152-w5ynbewh	89	23	nB	nB	NNP
cord-289152-w5ynbewh	89	24	to	to	TO
cord-289152-w5ynbewh	89	25	stimulate	stimulate	VB
cord-289152-w5ynbewh	89	26	expression	expression	NN
cord-289152-w5ynbewh	89	27	of	of	IN
cord-289152-w5ynbewh	89	28	target	target	NN
cord-289152-w5ynbewh	89	29	genes	gene	NNS
cord-289152-w5ynbewh	89	30	.	.	.
cord-289152-w5ynbewh	90	1	Thus	thus	RB
cord-289152-w5ynbewh	90	2	,	,	,
cord-289152-w5ynbewh	90	3	an	an	DT
cord-289152-w5ynbewh	90	4	NF	nf	NN
cord-289152-w5ynbewh	90	5	-	-	HYPH
cord-289152-w5ynbewh	90	6	nB	nB	NNP
cord-289152-w5ynbewh	90	7	reporter	reporter	NN
cord-289152-w5ynbewh	90	8	assay	assay	NN
cord-289152-w5ynbewh	90	9	was	be	VBD
cord-289152-w5ynbewh	90	10	used	use	VBN
cord-289152-w5ynbewh	90	11	to	to	TO
cord-289152-w5ynbewh	90	12	determine	determine	VB
cord-289152-w5ynbewh	90	13	if	if	IN
cord-289152-w5ynbewh	90	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	90	15	infection	infection	NN
cord-289152-w5ynbewh	90	16	enhanced	enhance	VBD
cord-289152-w5ynbewh	90	17	NF	nf	NN
cord-289152-w5ynbewh	90	18	-	-	HYPH
cord-289152-w5ynbewh	90	19	nB	nb	RB
cord-289152-w5ynbewh	90	20	-	-	HYPH
cord-289152-w5ynbewh	90	21	regulated	regulate	VBN
cord-289152-w5ynbewh	90	22	gene	gene	NN
cord-289152-w5ynbewh	90	23	expression	expression	NN
cord-289152-w5ynbewh	90	24	.	.	.
cord-289152-w5ynbewh	91	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	91	2	cells	cell	NNS
cord-289152-w5ynbewh	91	3	were	be	VBD
cord-289152-w5ynbewh	91	4	transiently	transiently	RB
cord-289152-w5ynbewh	91	5	transfected	transfecte	VBN
cord-289152-w5ynbewh	91	6	with	with	IN
cord-289152-w5ynbewh	91	7	an	an	DT
cord-289152-w5ynbewh	91	8	NF	nf	NN
cord-289152-w5ynbewh	91	9	-	-	HYPH
cord-289152-w5ynbewh	91	10	nB	nb	NN
cord-289152-w5ynbewh	91	11	luciferase	luciferase	NN
cord-289152-w5ynbewh	91	12	reporter	reporter	NN
cord-289152-w5ynbewh	91	13	plasmid	plasmid	NN
cord-289152-w5ynbewh	91	14	(	(	-LRB-
cord-289152-w5ynbewh	91	15	NF	NF	NNP
cord-289152-w5ynbewh	91	16	-	-	HYPH
cord-289152-w5ynbewh	91	17	nB	nB	NNP
cord-289152-w5ynbewh	91	18	-	-	HYPH
cord-289152-w5ynbewh	91	19	LUC	LUC	NNP
cord-289152-w5ynbewh	91	20	)	)	-RRB-
cord-289152-w5ynbewh	91	21	,	,	,
cord-289152-w5ynbewh	91	22	which	which	WDT
cord-289152-w5ynbewh	91	23	contains	contain	VBZ
cord-289152-w5ynbewh	91	24	nB	nb	DT
cord-289152-w5ynbewh	91	25	binding	bind	VBG
cord-289152-w5ynbewh	91	26	motifs	motif	NNS
cord-289152-w5ynbewh	91	27	under	under	IN
cord-289152-w5ynbewh	91	28	the	the	DT
cord-289152-w5ynbewh	91	29	control	control	NN
cord-289152-w5ynbewh	91	30	of	of	IN
cord-289152-w5ynbewh	91	31	a	a	DT
cord-289152-w5ynbewh	91	32	CMV	CMV	NNP
cord-289152-w5ynbewh	91	33	promoter	promoter	NN
cord-289152-w5ynbewh	91	34	.	.	.
cord-289152-w5ynbewh	92	1	Therefore	therefore	RB
cord-289152-w5ynbewh	92	2	,	,	,
cord-289152-w5ynbewh	92	3	luciferase	luciferase	JJ
cord-289152-w5ynbewh	92	4	expression	expression	NN
cord-289152-w5ynbewh	92	5	is	be	VBZ
cord-289152-w5ynbewh	92	6	under	under	IN
cord-289152-w5ynbewh	92	7	control	control	NN
cord-289152-w5ynbewh	92	8	of	of	IN
cord-289152-w5ynbewh	92	9	NF	nf	NN
cord-289152-w5ynbewh	92	10	-	-	HYPH
cord-289152-w5ynbewh	92	11	nB	nB	NNP
cord-289152-w5ynbewh	92	12	activation	activation	NN
cord-289152-w5ynbewh	92	13	.	.	.
cord-289152-w5ynbewh	93	1	After	after	IN
cord-289152-w5ynbewh	93	2	transfection	transfection	NN
cord-289152-w5ynbewh	93	3	,	,	,
cord-289152-w5ynbewh	93	4	cells	cell	NNS
cord-289152-w5ynbewh	93	5	were	be	VBD
cord-289152-w5ynbewh	93	6	infected	infect	VBN
cord-289152-w5ynbewh	93	7	with	with	IN
cord-289152-w5ynbewh	93	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	93	9	for	for	IN
cord-289152-w5ynbewh	93	10	1	1	CD
cord-289152-w5ynbewh	93	11	h	h	NN
cord-289152-w5ynbewh	93	12	or	or	CC
cord-289152-w5ynbewh	93	13	left	leave	VBN
cord-289152-w5ynbewh	93	14	uninfected	uninfected	JJ
cord-289152-w5ynbewh	93	15	.	.	.
cord-289152-w5ynbewh	94	1	NF	nf	NN
cord-289152-w5ynbewh	94	2	-	-	HYPH
cord-289152-w5ynbewh	94	3	nB	nb	RB
cord-289152-w5ynbewh	94	4	-	-	HYPH
cord-289152-w5ynbewh	94	5	regulated	regulate	VBN
cord-289152-w5ynbewh	94	6	luciferase	luciferase	JJ
cord-289152-w5ynbewh	94	7	expression	expression	NN
cord-289152-w5ynbewh	94	8	was	be	VBD
cord-289152-w5ynbewh	94	9	significantly	significantly	RB
cord-289152-w5ynbewh	94	10	enhanced	enhance	VBN
cord-289152-w5ynbewh	94	11	during	during	IN
cord-289152-w5ynbewh	94	12	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	94	13	infection	infection	NN
cord-289152-w5ynbewh	94	14	at	at	IN
cord-289152-w5ynbewh	94	15	36	36	CD
cord-289152-w5ynbewh	94	16	and	and	CC
cord-289152-w5ynbewh	94	17	48	48	CD
cord-289152-w5ynbewh	94	18	h	h	NN
cord-289152-w5ynbewh	94	19	p.i	p.i	NNP
cord-289152-w5ynbewh	94	20	.	.	NNP
cord-289152-w5ynbewh	94	21	which	which	WDT
cord-289152-w5ynbewh	94	22	correlated	correlate	VBD
cord-289152-w5ynbewh	94	23	with	with	IN
cord-289152-w5ynbewh	94	24	an	an	DT
cord-289152-w5ynbewh	94	25	increased	increase	VBN
cord-289152-w5ynbewh	94	26	level	level	NN
cord-289152-w5ynbewh	94	27	of	of	IN
cord-289152-w5ynbewh	94	28	NF	nf	NN
cord-289152-w5ynbewh	94	29	-	-	HYPH
cord-289152-w5ynbewh	94	30	nB	nb	NN
cord-289152-w5ynbewh	94	31	DNA	dna	NN
cord-289152-w5ynbewh	94	32	binding	binding	NN
cord-289152-w5ynbewh	94	33	activity	activity	NN
cord-289152-w5ynbewh	94	34	(	(	-LRB-
cord-289152-w5ynbewh	94	35	Fig	Fig	NNP
cord-289152-w5ynbewh	94	36	.	.	.
cord-289152-w5ynbewh	94	37	3A	3A	NNP
cord-289152-w5ynbewh	94	38	)	)	-RRB-
cord-289152-w5ynbewh	94	39	.	.	.
cord-289152-w5ynbewh	95	1	NF	nf	NN
cord-289152-w5ynbewh	95	2	-	-	HYPH
cord-289152-w5ynbewh	95	3	nB	nb	NN
cord-289152-w5ynbewh	95	4	activity	activity	NN
cord-289152-w5ynbewh	95	5	was	be	VBD
cord-289152-w5ynbewh	95	6	2.53-fold	2.53-fold	CD
cord-289152-w5ynbewh	95	7	and	and	CC
cord-289152-w5ynbewh	95	8	6.08-fold	6.08-fold	CD
cord-289152-w5ynbewh	95	9	higher	high	JJR
cord-289152-w5ynbewh	95	10	in	in	IN
cord-289152-w5ynbewh	95	11	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	95	12	-	-	HYPH
cord-289152-w5ynbewh	95	13	infected	infect	VBN
cord-289152-w5ynbewh	95	14	cells	cell	NNS
cord-289152-w5ynbewh	95	15	at	at	IN
cord-289152-w5ynbewh	95	16	36	36	CD
cord-289152-w5ynbewh	95	17	and	and	CC
cord-289152-w5ynbewh	95	18	48	48	CD
cord-289152-w5ynbewh	95	19	h	h	NN
cord-289152-w5ynbewh	95	20	p.i	p.i	NNP
cord-289152-w5ynbewh	95	21	.	.	NNP
cord-289152-w5ynbewh	95	22	compared	compare	VBN
cord-289152-w5ynbewh	95	23	to	to	IN
cord-289152-w5ynbewh	95	24	uninfected	uninfected	JJ
cord-289152-w5ynbewh	95	25	control	control	NN
cord-289152-w5ynbewh	95	26	cells	cell	NNS
cord-289152-w5ynbewh	95	27	.	.	.
cord-289152-w5ynbewh	96	1	These	these	DT
cord-289152-w5ynbewh	96	2	findings	finding	NNS
cord-289152-w5ynbewh	96	3	show	show	VBP
cord-289152-w5ynbewh	96	4	that	that	IN
cord-289152-w5ynbewh	96	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	96	6	infection	infection	NN
cord-289152-w5ynbewh	96	7	stimulated	stimulate	VBD
cord-289152-w5ynbewh	96	8	NF	nf	NN
cord-289152-w5ynbewh	96	9	-	-	HYPH
cord-289152-w5ynbewh	96	10	nBregulated	nbregulated	JJ
cord-289152-w5ynbewh	96	11	gene	gene	NN
cord-289152-w5ynbewh	96	12	expression	expression	NN
cord-289152-w5ynbewh	96	13	late	late	RB
cord-289152-w5ynbewh	96	14	in	in	IN
cord-289152-w5ynbewh	96	15	infection	infection	NN
cord-289152-w5ynbewh	96	16	,	,	,
cord-289152-w5ynbewh	96	17	which	which	WDT
cord-289152-w5ynbewh	96	18	means	mean	VBZ
cord-289152-w5ynbewh	96	19	that	that	IN
cord-289152-w5ynbewh	96	20	NF	nf	NN
cord-289152-w5ynbewh	96	21	-	-	HYPH
cord-289152-w5ynbewh	96	22	nB	nB	NNP
cord-289152-w5ynbewh	96	23	activated	activate	VBN
cord-289152-w5ynbewh	96	24	by	by	IN
cord-289152-w5ynbewh	96	25	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	96	26	is	be	VBZ
cord-289152-w5ynbewh	96	27	transcriptionally	transcriptionally	RB
cord-289152-w5ynbewh	96	28	active	active	JJ
cord-289152-w5ynbewh	96	29	and	and	CC
cord-289152-w5ynbewh	96	30	functional	functional	JJ
cord-289152-w5ynbewh	96	31	.	.	.
cord-289152-w5ynbewh	97	1	To	to	TO
cord-289152-w5ynbewh	97	2	determine	determine	VB
cord-289152-w5ynbewh	97	3	if	if	IN
cord-289152-w5ynbewh	97	4	there	there	EX
cord-289152-w5ynbewh	97	5	was	be	VBD
cord-289152-w5ynbewh	97	6	a	a	DT
cord-289152-w5ynbewh	97	7	relationship	relationship	NN
cord-289152-w5ynbewh	97	8	between	between	IN
cord-289152-w5ynbewh	97	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	97	10	replication	replication	NN
cord-289152-w5ynbewh	97	11	and	and	CC
cord-289152-w5ynbewh	97	12	NF	nf	NN
cord-289152-w5ynbewh	97	13	-	-	HYPH
cord-289152-w5ynbewh	97	14	nB	nB	NNP
cord-289152-w5ynbewh	97	15	activation	activation	NN
cord-289152-w5ynbewh	97	16	,	,	,
cord-289152-w5ynbewh	97	17	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	97	18	cells	cell	NNS
cord-289152-w5ynbewh	97	19	were	be	VBD
cord-289152-w5ynbewh	97	20	infected	infect	VBN
cord-289152-w5ynbewh	97	21	at	at	IN
cord-289152-w5ynbewh	97	22	various	various	JJ
cord-289152-w5ynbewh	97	23	MOIs	moi	NNS
cord-289152-w5ynbewh	97	24	and	and	CC
cord-289152-w5ynbewh	97	25	NF	nf	NN
cord-289152-w5ynbewh	97	26	-	-	HYPH
cord-289152-w5ynbewh	97	27	nB	nB	NNP
cord-289152-w5ynbewh	97	28	activation	activation	NN
cord-289152-w5ynbewh	97	29	was	be	VBD
cord-289152-w5ynbewh	97	30	monitored	monitor	VBN
cord-289152-w5ynbewh	97	31	by	by	IN
cord-289152-w5ynbewh	97	32	measuring	measure	VBG
cord-289152-w5ynbewh	97	33	NF	nf	NN
cord-289152-w5ynbewh	97	34	-	-	HYPH
cord-289152-w5ynbewh	97	35	nB	nb	RB
cord-289152-w5ynbewh	97	36	-	-	HYPH
cord-289152-w5ynbewh	97	37	regulated	regulate	VBN
cord-289152-w5ynbewh	97	38	luciferase	luciferase	NN
cord-289152-w5ynbewh	97	39	expression	expression	NN
cord-289152-w5ynbewh	97	40	.	.	.
cord-289152-w5ynbewh	98	1	As	as	IN
cord-289152-w5ynbewh	98	2	shown	show	VBN
cord-289152-w5ynbewh	98	3	in	in	IN
cord-289152-w5ynbewh	98	4	Fig	Fig	NNP
cord-289152-w5ynbewh	98	5	.	.	.
cord-289152-w5ynbewh	98	6	3B	3B	NNP
cord-289152-w5ynbewh	98	7	,	,	,
cord-289152-w5ynbewh	98	8	a	a	DT
cord-289152-w5ynbewh	98	9	higher	high	JJR
cord-289152-w5ynbewh	98	10	MOI	MOI	NNP
cord-289152-w5ynbewh	98	11	resulted	result	VBD
cord-289152-w5ynbewh	98	12	in	in	IN
cord-289152-w5ynbewh	98	13	higher	high	JJR
cord-289152-w5ynbewh	98	14	levels	level	NNS
cord-289152-w5ynbewh	98	15	of	of	IN
cord-289152-w5ynbewh	98	16	NF	nf	NN
cord-289152-w5ynbewh	98	17	-	-	HYPH
cord-289152-w5ynbewh	98	18	nB	nB	NNP
cord-289152-w5ynbewh	98	19	activation	activation	NN
cord-289152-w5ynbewh	98	20	,	,	,
cord-289152-w5ynbewh	98	21	suggesting	suggest	VBG
cord-289152-w5ynbewh	98	22	that	that	IN
cord-289152-w5ynbewh	98	23	NF	nf	NN
cord-289152-w5ynbewh	98	24	-	-	HYPH
cord-289152-w5ynbewh	98	25	nB	nB	NNP
cord-289152-w5ynbewh	98	26	activation	activation	NN
cord-289152-w5ynbewh	98	27	by	by	IN
cord-289152-w5ynbewh	98	28	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	98	29	is	be	VBZ
cord-289152-w5ynbewh	98	30	viral	viral	JJ
cord-289152-w5ynbewh	98	31	dose	dose	NN
cord-289152-w5ynbewh	98	32	-	-	HYPH
cord-289152-w5ynbewh	98	33	dependent	dependent	JJ
cord-289152-w5ynbewh	98	34	.	.	.
cord-289152-w5ynbewh	99	1	In	in	IN
cord-289152-w5ynbewh	99	2	some	some	DT
cord-289152-w5ynbewh	99	3	viral	viral	JJ
cord-289152-w5ynbewh	99	4	infections	infection	NNS
cord-289152-w5ynbewh	99	5	,	,	,
cord-289152-w5ynbewh	99	6	binding	bind	VBG
cord-289152-w5ynbewh	99	7	of	of	IN
cord-289152-w5ynbewh	99	8	the	the	DT
cord-289152-w5ynbewh	99	9	viral	viral	JJ
cord-289152-w5ynbewh	99	10	particle	particle	NN
cord-289152-w5ynbewh	99	11	to	to	IN
cord-289152-w5ynbewh	99	12	a	a	DT
cord-289152-w5ynbewh	99	13	cellular	cellular	JJ
cord-289152-w5ynbewh	99	14	surface	surface	NN
cord-289152-w5ynbewh	99	15	receptor	receptor	NN
cord-289152-w5ynbewh	99	16	is	be	VBZ
cord-289152-w5ynbewh	99	17	sufficient	sufficient	JJ
cord-289152-w5ynbewh	99	18	to	to	TO
cord-289152-w5ynbewh	99	19	trigger	trigger	VB
cord-289152-w5ynbewh	99	20	signaling	signal	VBG
cord-289152-w5ynbewh	99	21	cascades	cascade	NNS
cord-289152-w5ynbewh	99	22	that	that	WDT
cord-289152-w5ynbewh	99	23	activate	activate	VBP
cord-289152-w5ynbewh	99	24	NF	nf	NN
cord-289152-w5ynbewh	99	25	-	-	HYPH
cord-289152-w5ynbewh	99	26	nB.	nb.	NN
cord-289152-w5ynbewh	100	1	To	to	TO
cord-289152-w5ynbewh	100	2	test	test	VB
cord-289152-w5ynbewh	100	3	this	this	DT
cord-289152-w5ynbewh	100	4	possibility	possibility	NN
cord-289152-w5ynbewh	100	5	,	,	,
cord-289152-w5ynbewh	100	6	UV	uv	NN
cord-289152-w5ynbewh	100	7	-	-	HYPH
cord-289152-w5ynbewh	100	8	inactivated	inactivate	VBN
cord-289152-w5ynbewh	100	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	100	10	was	be	VBD
cord-289152-w5ynbewh	100	11	used	use	VBN
cord-289152-w5ynbewh	100	12	to	to	TO
cord-289152-w5ynbewh	100	13	determine	determine	VB
cord-289152-w5ynbewh	100	14	if	if	IN
cord-289152-w5ynbewh	100	15	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	100	16	binding	bind	VBG
cord-289152-w5ynbewh	100	17	to	to	IN
cord-289152-w5ynbewh	100	18	its	-PRON-	PRP$
cord-289152-w5ynbewh	100	19	receptor	receptor	NN
cord-289152-w5ynbewh	100	20	mediates	mediate	VBZ
cord-289152-w5ynbewh	100	21	NF	nf	NN
cord-289152-w5ynbewh	100	22	-	-	HYPH
cord-289152-w5ynbewh	100	23	nB	nB	NNP
cord-289152-w5ynbewh	100	24	activation	activation	NN
cord-289152-w5ynbewh	100	25	.	.	.
cord-289152-w5ynbewh	101	1	As	as	IN
cord-289152-w5ynbewh	101	2	shown	show	VBN
cord-289152-w5ynbewh	101	3	in	in	IN
cord-289152-w5ynbewh	101	4	Fig	Fig	NNP
cord-289152-w5ynbewh	101	5	.	.	.
cord-289152-w5ynbewh	102	1	3B	3B	NNP
cord-289152-w5ynbewh	102	2	,	,	,
cord-289152-w5ynbewh	102	3	UV	uv	NN
cord-289152-w5ynbewh	102	4	-	-	HYPH
cord-289152-w5ynbewh	102	5	inactivation	inactivation	NN
cord-289152-w5ynbewh	102	6	of	of	IN
cord-289152-w5ynbewh	102	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	102	8	decreased	decrease	VBD
cord-289152-w5ynbewh	103	1	NF	NF	NNP
cord-289152-w5ynbewh	103	2	-	-	HYPH
cord-289152-w5ynbewh	103	3	nB	nB	NNP
cord-289152-w5ynbewh	103	4	activation	activation	NN
cord-289152-w5ynbewh	103	5	compared	compare	VBN
cord-289152-w5ynbewh	103	6	to	to	IN
cord-289152-w5ynbewh	103	7	infection	infection	NN
cord-289152-w5ynbewh	103	8	with	with	IN
cord-289152-w5ynbewh	103	9	noninactivated	noninactivated	NNP
cord-289152-w5ynbewh	103	10	(	(	-LRB-
cord-289152-w5ynbewh	103	11	fully	fully	RB
cord-289152-w5ynbewh	103	12	infectious	infectious	JJ
cord-289152-w5ynbewh	103	13	)	)	-RRB-
cord-289152-w5ynbewh	103	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	103	15	.	.	.
cord-289152-w5ynbewh	104	1	NF	nf	NN
cord-289152-w5ynbewh	104	2	-	-	HYPH
cord-289152-w5ynbewh	104	3	nB	nb	RB
cord-289152-w5ynbewh	104	4	-	-	HYPH
cord-289152-w5ynbewh	104	5	regulated	regulate	VBN
cord-289152-w5ynbewh	104	6	gene	gene	NN
cord-289152-w5ynbewh	104	7	expression	expression	NN
cord-289152-w5ynbewh	104	8	was	be	VBD
cord-289152-w5ynbewh	104	9	reduced	reduce	VBN
cord-289152-w5ynbewh	104	10	from	from	IN
cord-289152-w5ynbewh	104	11	3.34-fold	3.34-fold	NNP
cord-289152-w5ynbewh	104	12	to	to	IN
cord-289152-w5ynbewh	104	13	1.43-fold	1.43-fold	CD
cord-289152-w5ynbewh	104	14	at	at	IN
cord-289152-w5ynbewh	104	15	MOI	MOI	NNP
cord-289152-w5ynbewh	104	16	=	=	SYM
cord-289152-w5ynbewh	104	17	1	1	CD
cord-289152-w5ynbewh	104	18	,	,	,
cord-289152-w5ynbewh	104	19	from	from	IN
cord-289152-w5ynbewh	104	20	1.99-fold	1.99-fold	CD
cord-289152-w5ynbewh	104	21	to	to	IN
cord-289152-w5ynbewh	104	22	1.15	1.15	CD
cord-289152-w5ynbewh	104	23	at	at	IN
cord-289152-w5ynbewh	104	24	MOI	MOI	NNP
cord-289152-w5ynbewh	104	25	=	=	SYM
cord-289152-w5ynbewh	104	26	0.1	0.1	CD
cord-289152-w5ynbewh	104	27	,	,	,
cord-289152-w5ynbewh	104	28	and	and	CC
cord-289152-w5ynbewh	104	29	from	from	IN
cord-289152-w5ynbewh	104	30	1.42-fold	1.42-fold	CD
cord-289152-w5ynbewh	104	31	to	to	IN
cord-289152-w5ynbewh	104	32	0.96-fold	0.96-fold	CD
cord-289152-w5ynbewh	104	33	at	at	IN
cord-289152-w5ynbewh	104	34	MOI	MOI	NNP
cord-289152-w5ynbewh	104	35	=	=	SYM
cord-289152-w5ynbewh	104	36	0.01	0.01	CD
cord-289152-w5ynbewh	104	37	.	.	.
cord-289152-w5ynbewh	105	1	These	these	DT
cord-289152-w5ynbewh	105	2	data	datum	NNS
cord-289152-w5ynbewh	105	3	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	105	4	that	that	IN
cord-289152-w5ynbewh	105	5	NF	nf	NN
cord-289152-w5ynbewh	105	6	-	-	HYPH
cord-289152-w5ynbewh	105	7	nB	nB	NNP
cord-289152-w5ynbewh	105	8	levels	level	NNS
cord-289152-w5ynbewh	105	9	are	be	VBP
cord-289152-w5ynbewh	105	10	elevated	elevate	VBN
cord-289152-w5ynbewh	105	11	primarily	primarily	RB
cord-289152-w5ynbewh	105	12	as	as	IN
cord-289152-w5ynbewh	105	13	a	a	DT
cord-289152-w5ynbewh	105	14	result	result	NN
cord-289152-w5ynbewh	105	15	of	of	IN
cord-289152-w5ynbewh	105	16	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	105	17	replication	replication	NN
cord-289152-w5ynbewh	105	18	and	and	CC
cord-289152-w5ynbewh	105	19	that	that	IN
cord-289152-w5ynbewh	105	20	UV	uv	NN
cord-289152-w5ynbewh	105	21	-	-	HYPH
cord-289152-w5ynbewh	105	22	inactivation	inactivation	NN
cord-289152-w5ynbewh	105	23	of	of	IN
cord-289152-w5ynbewh	105	24	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	105	25	significantly	significantly	RB
cord-289152-w5ynbewh	105	26	decreased	decrease	VBD
cord-289152-w5ynbewh	105	27	this	this	DT
cord-289152-w5ynbewh	105	28	effect	effect	NN
cord-289152-w5ynbewh	105	29	.	.	.
cord-289152-w5ynbewh	106	1	A	a	DT
cord-289152-w5ynbewh	106	2	key	key	JJ
cord-289152-w5ynbewh	106	3	step	step	NN
cord-289152-w5ynbewh	106	4	that	that	WDT
cord-289152-w5ynbewh	106	5	leads	lead	VBZ
cord-289152-w5ynbewh	106	6	to	to	IN
cord-289152-w5ynbewh	106	7	NF	nf	NN
cord-289152-w5ynbewh	106	8	-	-	HYPH
cord-289152-w5ynbewh	106	9	nB	nB	NNP
cord-289152-w5ynbewh	106	10	activation	activation	NN
cord-289152-w5ynbewh	106	11	in	in	IN
cord-289152-w5ynbewh	106	12	response	response	NN
cord-289152-w5ynbewh	106	13	to	to	IN
cord-289152-w5ynbewh	106	14	many	many	JJ
cord-289152-w5ynbewh	106	15	extracellular	extracellular	JJ
cord-289152-w5ynbewh	106	16	stimuli	stimulus	NNS
cord-289152-w5ynbewh	106	17	is	be	VBZ
cord-289152-w5ynbewh	106	18	degradation	degradation	NN
cord-289152-w5ynbewh	106	19	of	of	IN
cord-289152-w5ynbewh	106	20	InB	inb	NN
cord-289152-w5ynbewh	106	21	proteins	protein	NNS
cord-289152-w5ynbewh	106	22	.	.	.
cord-289152-w5ynbewh	107	1	Therefore	therefore	RB
cord-289152-w5ynbewh	107	2	,	,	,
cord-289152-w5ynbewh	107	3	it	-PRON-	PRP
cord-289152-w5ynbewh	107	4	was	be	VBD
cord-289152-w5ynbewh	107	5	determined	determine	VBN
cord-289152-w5ynbewh	107	6	if	if	IN
cord-289152-w5ynbewh	107	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	107	8	-	-	HYPH
cord-289152-w5ynbewh	107	9	mediated	mediate	VBN
cord-289152-w5ynbewh	107	10	changes	change	NNS
cord-289152-w5ynbewh	107	11	in	in	IN
cord-289152-w5ynbewh	107	12	the	the	DT
cord-289152-w5ynbewh	107	13	InB	inb	NN
cord-289152-w5ynbewh	107	14	proteins	protein	NNS
cord-289152-w5ynbewh	107	15	correlated	correlate	VBN
cord-289152-w5ynbewh	107	16	with	with	IN
cord-289152-w5ynbewh	107	17	increased	increase	VBN
cord-289152-w5ynbewh	107	18	NF	nf	NN
cord-289152-w5ynbewh	107	19	-	-	HYPH
cord-289152-w5ynbewh	107	20	nB	nb	NN
cord-289152-w5ynbewh	107	21	activity	activity	NN
cord-289152-w5ynbewh	107	22	.	.	.
cord-289152-w5ynbewh	108	1	Protein	protein	NN
cord-289152-w5ynbewh	108	2	levels	level	NNS
cord-289152-w5ynbewh	108	3	of	of	IN
cord-289152-w5ynbewh	108	4	InBa	InBa	NNP
cord-289152-w5ynbewh	108	5	,	,	,
cord-289152-w5ynbewh	108	6	InBh	InBh	NNP
cord-289152-w5ynbewh	108	7	,	,	,
cord-289152-w5ynbewh	108	8	and	and	CC
cord-289152-w5ynbewh	108	9	InBe	InBe	NNP
cord-289152-w5ynbewh	108	10	were	be	VBD
cord-289152-w5ynbewh	108	11	monitored	monitor	VBN
cord-289152-w5ynbewh	108	12	by	by	IN
cord-289152-w5ynbewh	108	13	Western	western	JJ
cord-289152-w5ynbewh	108	14	blot	blot	NN
cord-289152-w5ynbewh	108	15	analysis	analysis	NN
cord-289152-w5ynbewh	108	16	following	follow	VBG
cord-289152-w5ynbewh	108	17	a	a	DT
cord-289152-w5ynbewh	108	18	time	time	NN
cord-289152-w5ynbewh	108	19	course	course	NN
cord-289152-w5ynbewh	108	20	of	of	IN
cord-289152-w5ynbewh	108	21	infection	infection	NN
cord-289152-w5ynbewh	108	22	in	in	IN
cord-289152-w5ynbewh	108	23	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	108	24	cells	cell	NNS
cord-289152-w5ynbewh	108	25	and	and	CC
cord-289152-w5ynbewh	108	26	PAM	PAM	NNP
cord-289152-w5ynbewh	108	27	cultures	culture	NNS
cord-289152-w5ynbewh	108	28	.	.	.
cord-289152-w5ynbewh	109	1	Results	result	NNS
cord-289152-w5ynbewh	109	2	in	in	IN
cord-289152-w5ynbewh	109	3	Fig	Fig	NNP
cord-289152-w5ynbewh	109	4	.	.	.
cord-289152-w5ynbewh	110	1	4	4	LS
cord-289152-w5ynbewh	110	2	show	show	VBP
cord-289152-w5ynbewh	110	3	that	that	IN
cord-289152-w5ynbewh	110	4	InBa	InBa	NNP
cord-289152-w5ynbewh	110	5	,	,	,
cord-289152-w5ynbewh	110	6	InBh	InBh	NNP
cord-289152-w5ynbewh	110	7	,	,	,
cord-289152-w5ynbewh	110	8	and	and	CC
cord-289152-w5ynbewh	110	9	InBe	InBe	NNP
cord-289152-w5ynbewh	110	10	were	be	VBD
cord-289152-w5ynbewh	110	11	found	find	VBN
cord-289152-w5ynbewh	110	12	in	in	IN
cord-289152-w5ynbewh	110	13	uninfected	uninfected	JJ
cord-289152-w5ynbewh	110	14	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	110	15	cells	cell	NNS
cord-289152-w5ynbewh	110	16	and	and	CC
cord-289152-w5ynbewh	110	17	PAMs	pam	NNS
cord-289152-w5ynbewh	110	18	and	and	CC
cord-289152-w5ynbewh	110	19	the	the	DT
cord-289152-w5ynbewh	110	20	protein	protein	NN
cord-289152-w5ynbewh	110	21	levels	level	NNS
cord-289152-w5ynbewh	110	22	were	be	VBD
cord-289152-w5ynbewh	110	23	mostly	mostly	RB
cord-289152-w5ynbewh	110	24	unchanged	unchanged	JJ
cord-289152-w5ynbewh	110	25	throughout	throughout	IN
cord-289152-w5ynbewh	110	26	the	the	DT
cord-289152-w5ynbewh	110	27	time	time	NN
cord-289152-w5ynbewh	110	28	course	course	NN
cord-289152-w5ynbewh	110	29	.	.	.
cord-289152-w5ynbewh	111	1	In	in	IN
cord-289152-w5ynbewh	111	2	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	111	3	cells	cell	NNS
cord-289152-w5ynbewh	111	4	(	(	-LRB-
cord-289152-w5ynbewh	111	5	Fig	fig	NN
cord-289152-w5ynbewh	111	6	.	.	.
cord-289152-w5ynbewh	111	7	4A	4a	CD
cord-289152-w5ynbewh	111	8	)	)	-RRB-
cord-289152-w5ynbewh	111	9	,	,	,
cord-289152-w5ynbewh	111	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	111	11	infection	infection	NN
cord-289152-w5ynbewh	111	12	resulted	result	VBD
cord-289152-w5ynbewh	111	13	in	in	IN
cord-289152-w5ynbewh	111	14	a	a	DT
cord-289152-w5ynbewh	111	15	lower	low	JJR
cord-289152-w5ynbewh	111	16	concentration	concentration	NN
cord-289152-w5ynbewh	111	17	of	of	IN
cord-289152-w5ynbewh	111	18	InBa	InBa	NNP
cord-289152-w5ynbewh	111	19	at	at	IN
cord-289152-w5ynbewh	111	20	48	48	CD
cord-289152-w5ynbewh	111	21	h	h	NN
cord-289152-w5ynbewh	111	22	p.i	p.i	NNP
cord-289152-w5ynbewh	111	23	.	.	NNP
cord-289152-w5ynbewh	111	24	compared	compare	VBN
cord-289152-w5ynbewh	111	25	to	to	IN
cord-289152-w5ynbewh	111	26	uninfected	uninfected	JJ
cord-289152-w5ynbewh	111	27	control	control	NN
cord-289152-w5ynbewh	111	28	cells	cell	NNS
cord-289152-w5ynbewh	111	29	,	,	,
cord-289152-w5ynbewh	111	30	suggesting	suggest	VBG
cord-289152-w5ynbewh	111	31	proteosomal	proteosomal	JJ
cord-289152-w5ynbewh	111	32	degradation	degradation	NN
cord-289152-w5ynbewh	111	33	of	of	IN
cord-289152-w5ynbewh	111	34	InBa	InBa	NNP
cord-289152-w5ynbewh	111	35	.	.	.
cord-289152-w5ynbewh	112	1	This	this	DT
cord-289152-w5ynbewh	112	2	correlated	correlate	VBD
cord-289152-w5ynbewh	112	3	with	with	IN
cord-289152-w5ynbewh	112	4	the	the	DT
cord-289152-w5ynbewh	112	5	highest	high	JJS
cord-289152-w5ynbewh	112	6	NF	nf	NN
cord-289152-w5ynbewh	112	7	-	-	HYPH
cord-289152-w5ynbewh	112	8	nB	nb	NN
cord-289152-w5ynbewh	112	9	activity	activity	NN
cord-289152-w5ynbewh	112	10	at	at	IN
cord-289152-w5ynbewh	112	11	48	48	CD
cord-289152-w5ynbewh	112	12	h	h	NN
cord-289152-w5ynbewh	112	13	p.i	p.i	NNP
cord-289152-w5ynbewh	112	14	.	.	.
cord-289152-w5ynbewh	113	1	among	among	IN
cord-289152-w5ynbewh	113	2	the	the	DT
cord-289152-w5ynbewh	113	3	time	time	NN
cord-289152-w5ynbewh	113	4	points	point	NNS
cord-289152-w5ynbewh	113	5	tested	test	VBN
cord-289152-w5ynbewh	113	6	.	.	.
cord-289152-w5ynbewh	114	1	However	however	RB
cord-289152-w5ynbewh	114	2	,	,	,
cord-289152-w5ynbewh	114	3	InBa	InBa	NNP
cord-289152-w5ynbewh	114	4	was	be	VBD
cord-289152-w5ynbewh	114	5	still	still	RB
cord-289152-w5ynbewh	114	6	weakly	weakly	RB
cord-289152-w5ynbewh	114	7	detectable	detectable	JJ
cord-289152-w5ynbewh	114	8	in	in	IN
cord-289152-w5ynbewh	114	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	114	10	-	-	HYPH
cord-289152-w5ynbewh	114	11	infected	infect	VBN
cord-289152-w5ynbewh	114	12	cells	cell	NNS
cord-289152-w5ynbewh	114	13	at	at	IN
cord-289152-w5ynbewh	114	14	late	late	JJ
cord-289152-w5ynbewh	114	15	times	time	NNS
cord-289152-w5ynbewh	114	16	p.i	p.i	NNP
cord-289152-w5ynbewh	114	17	.	.	NNP
cord-289152-w5ynbewh	114	18	InBh	InBh	NNP
cord-289152-w5ynbewh	114	19	and	and	CC
cord-289152-w5ynbewh	114	20	InBe	InBe	NNP
cord-289152-w5ynbewh	114	21	remained	remain	VBD
cord-289152-w5ynbewh	114	22	relatively	relatively	RB
cord-289152-w5ynbewh	114	23	constant	constant	JJ
cord-289152-w5ynbewh	114	24	at	at	IN
cord-289152-w5ynbewh	114	25	all	all	DT
cord-289152-w5ynbewh	114	26	time	time	NN
cord-289152-w5ynbewh	114	27	points	point	NNS
cord-289152-w5ynbewh	114	28	in	in	IN
cord-289152-w5ynbewh	114	29	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	114	30	-	-	HYPH
cord-289152-w5ynbewh	114	31	infected	infect	VBN
cord-289152-w5ynbewh	114	32	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	114	33	cells	cell	NNS
cord-289152-w5ynbewh	114	34	.	.	.
cord-289152-w5ynbewh	115	1	In	in	IN
cord-289152-w5ynbewh	115	2	PAM	PAM	NNP
cord-289152-w5ynbewh	115	3	cultures	culture	NNS
cord-289152-w5ynbewh	115	4	,	,	,
cord-289152-w5ynbewh	115	5	degradation	degradation	NN
cord-289152-w5ynbewh	115	6	of	of	IN
cord-289152-w5ynbewh	115	7	InBa	InBa	NNP
cord-289152-w5ynbewh	115	8	and	and	CC
cord-289152-w5ynbewh	115	9	InBe	InBe	NNP
cord-289152-w5ynbewh	115	10	was	be	VBD
cord-289152-w5ynbewh	115	11	detected	detect	VBN
cord-289152-w5ynbewh	115	12	after	after	IN
cord-289152-w5ynbewh	115	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	115	14	infection	infection	NN
cord-289152-w5ynbewh	115	15	at	at	IN
cord-289152-w5ynbewh	115	16	48	48	CD
cord-289152-w5ynbewh	115	17	h	h	NN
cord-289152-w5ynbewh	115	18	and	and	CC
cord-289152-w5ynbewh	115	19	60	60	CD
cord-289152-w5ynbewh	115	20	h	h	NN
cord-289152-w5ynbewh	115	21	p.i	p.i	NNP
cord-289152-w5ynbewh	115	22	.	.	NNP
cord-289152-w5ynbewh	115	23	as	as	IN
cord-289152-w5ynbewh	115	24	shown	show	VBN
cord-289152-w5ynbewh	115	25	in	in	IN
cord-289152-w5ynbewh	115	26	Fig	Fig	NNP
cord-289152-w5ynbewh	115	27	.	.	.
cord-289152-w5ynbewh	115	28	4B	4b	CD
cord-289152-w5ynbewh	115	29	.	.	.
cord-289152-w5ynbewh	116	1	The	the	DT
cord-289152-w5ynbewh	116	2	degradation	degradation	NN
cord-289152-w5ynbewh	116	3	of	of	IN
cord-289152-w5ynbewh	116	4	InBh	InBh	NNP
cord-289152-w5ynbewh	116	5	protein	protein	NN
cord-289152-w5ynbewh	116	6	was	be	VBD
cord-289152-w5ynbewh	116	7	detected	detect	VBN
cord-289152-w5ynbewh	116	8	at	at	IN
cord-289152-w5ynbewh	116	9	60	60	CD
cord-289152-w5ynbewh	116	10	h	h	NN
cord-289152-w5ynbewh	116	11	p.i	p.i	NNP
cord-289152-w5ynbewh	116	12	.	.	.
cord-289152-w5ynbewh	117	1	The	the	DT
cord-289152-w5ynbewh	117	2	onset	onset	NN
cord-289152-w5ynbewh	117	3	of	of	IN
cord-289152-w5ynbewh	117	4	the	the	DT
cord-289152-w5ynbewh	117	5	degradation	degradation	NN
cord-289152-w5ynbewh	117	6	of	of	IN
cord-289152-w5ynbewh	117	7	InB	inb	NN
cord-289152-w5ynbewh	117	8	proteins	protein	NNS
cord-289152-w5ynbewh	117	9	correlated	correlate	VBN
cord-289152-w5ynbewh	117	10	with	with	IN
cord-289152-w5ynbewh	117	11	the	the	DT
cord-289152-w5ynbewh	117	12	NF	nf	NN
cord-289152-w5ynbewh	117	13	-	-	HYPH
cord-289152-w5ynbewh	117	14	nB	nB	NNP
cord-289152-w5ynbewh	117	15	activation	activation	NN
cord-289152-w5ynbewh	117	16	later	later	RB
cord-289152-w5ynbewh	117	17	in	in	IN
cord-289152-w5ynbewh	117	18	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	117	19	infection	infection	NN
cord-289152-w5ynbewh	117	20	as	as	IN
cord-289152-w5ynbewh	117	21	observed	observe	VBN
cord-289152-w5ynbewh	117	22	above	above	RB
cord-289152-w5ynbewh	117	23	.	.	.
cord-289152-w5ynbewh	118	1	For	for	IN
cord-289152-w5ynbewh	118	2	both	both	CC
cord-289152-w5ynbewh	118	3	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	118	4	cells	cell	NNS
cord-289152-w5ynbewh	118	5	and	and	CC
cord-289152-w5ynbewh	118	6	PAM	PAM	NNP
cord-289152-w5ynbewh	118	7	cultures	culture	NNS
cord-289152-w5ynbewh	118	8	,	,	,
cord-289152-w5ynbewh	118	9	the	the	DT
cord-289152-w5ynbewh	118	10	same	same	JJ
cord-289152-w5ynbewh	118	11	blot	blot	NN
cord-289152-w5ynbewh	118	12	was	be	VBD
cord-289152-w5ynbewh	118	13	also	also	RB
cord-289152-w5ynbewh	118	14	reacted	react	VBN
cord-289152-w5ynbewh	118	15	with	with	IN
cord-289152-w5ynbewh	118	16	an	an	DT
cord-289152-w5ynbewh	118	17	actin	actin	NN
cord-289152-w5ynbewh	118	18	-	-	HYPH
cord-289152-w5ynbewh	118	19	specific	specific	JJ
cord-289152-w5ynbewh	118	20	antibody	antibody	NN
cord-289152-w5ynbewh	118	21	to	to	TO
cord-289152-w5ynbewh	118	22	confirm	confirm	VB
cord-289152-w5ynbewh	118	23	that	that	IN
cord-289152-w5ynbewh	118	24	comparable	comparable	JJ
cord-289152-w5ynbewh	118	25	amounts	amount	NNS
cord-289152-w5ynbewh	118	26	of	of	IN
cord-289152-w5ynbewh	118	27	protein	protein	NN
cord-289152-w5ynbewh	118	28	were	be	VBD
cord-289152-w5ynbewh	118	29	loaded	load	VBN
cord-289152-w5ynbewh	118	30	in	in	IN
cord-289152-w5ynbewh	118	31	each	each	DT
cord-289152-w5ynbewh	118	32	lane	lane	NN
cord-289152-w5ynbewh	118	33	.	.	.
cord-289152-w5ynbewh	119	1	#	#	NN
cord-289152-w5ynbewh	119	2	P	p	NN
cord-289152-w5ynbewh	119	3	<	<	XX
cord-289152-w5ynbewh	119	4	0.05	0.05	CD
cord-289152-w5ynbewh	119	5	compared	compare	VBN
cord-289152-w5ynbewh	119	6	to	to	IN
cord-289152-w5ynbewh	119	7	mock	mock	VB
cord-289152-w5ynbewh	119	8	-	-	HYPH
cord-289152-w5ynbewh	119	9	infected	infected	JJ
cord-289152-w5ynbewh	119	10	control	control	NN
cord-289152-w5ynbewh	119	11	,	,	,
cord-289152-w5ynbewh	120	1	*	*	NFP
cord-289152-w5ynbewh	120	2	P	p	XX
cord-289152-w5ynbewh	120	3	<	<	XX
cord-289152-w5ynbewh	120	4	0.01	0.01	CD
cord-289152-w5ynbewh	120	5	compared	compare	VBN
cord-289152-w5ynbewh	120	6	to	to	IN
cord-289152-w5ynbewh	120	7	mock	mock	VB
cord-289152-w5ynbewh	120	8	-	-	HYPH
cord-289152-w5ynbewh	120	9	infected	infect	VBN
cord-289152-w5ynbewh	120	10	control	control	NN
cord-289152-w5ynbewh	120	11	.	.	.
cord-289152-w5ynbewh	121	1	Results	result	NNS
cord-289152-w5ynbewh	121	2	are	be	VBP
cord-289152-w5ynbewh	121	3	representative	representative	JJ
cord-289152-w5ynbewh	121	4	of	of	IN
cord-289152-w5ynbewh	121	5	at	at	RB
cord-289152-w5ynbewh	121	6	least	least	RBS
cord-289152-w5ynbewh	121	7	three	three	CD
cord-289152-w5ynbewh	121	8	independent	independent	JJ
cord-289152-w5ynbewh	121	9	experiments	experiment	NNS
cord-289152-w5ynbewh	121	10	.	.	.
cord-289152-w5ynbewh	122	1	(	(	-LRB-
cord-289152-w5ynbewh	122	2	B	b	NN
cord-289152-w5ynbewh	122	3	)	)	-RRB-
cord-289152-w5ynbewh	122	4	MARC-145	marc-145	NN
cord-289152-w5ynbewh	122	5	cells	cell	NNS
cord-289152-w5ynbewh	122	6	transfected	transfecte	VBN
cord-289152-w5ynbewh	122	7	with	with	IN
cord-289152-w5ynbewh	122	8	NF	nf	NN
cord-289152-w5ynbewh	122	9	-	-	HYPH
cord-289152-w5ynbewh	122	10	nB	nB	NNP
cord-289152-w5ynbewh	122	11	-	-	HYPH
cord-289152-w5ynbewh	122	12	Luc	Luc	NNP
cord-289152-w5ynbewh	122	13	and	and	CC
cord-289152-w5ynbewh	122	14	phRG	phRG	NNP
cord-289152-w5ynbewh	122	15	-	-	HYPH
cord-289152-w5ynbewh	122	16	TK	tk	NN
cord-289152-w5ynbewh	122	17	plasmid	plasmid	NN
cord-289152-w5ynbewh	122	18	were	be	VBD
cord-289152-w5ynbewh	122	19	infected	infect	VBN
cord-289152-w5ynbewh	122	20	with	with	IN
cord-289152-w5ynbewh	122	21	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	122	22	or	or	CC
cord-289152-w5ynbewh	122	23	UV	uv	NN
cord-289152-w5ynbewh	122	24	-	-	HYPH
cord-289152-w5ynbewh	122	25	inactivated	inactivate	VBN
cord-289152-w5ynbewh	122	26	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	122	27	at	at	IN
cord-289152-w5ynbewh	122	28	MOI	MOI	NNP
cord-289152-w5ynbewh	122	29	=	=	SYM
cord-289152-w5ynbewh	122	30	1	1	CD
cord-289152-w5ynbewh	122	31	,	,	,
cord-289152-w5ynbewh	122	32	0.1	0.1	CD
cord-289152-w5ynbewh	122	33	,	,	,
cord-289152-w5ynbewh	122	34	and	and	CC
cord-289152-w5ynbewh	122	35	0.01	0.01	CD
cord-289152-w5ynbewh	122	36	for	for	IN
cord-289152-w5ynbewh	122	37	1	1	CD
cord-289152-w5ynbewh	122	38	h.	h.	NN
cord-289152-w5ynbewh	122	39	After	after	IN
cord-289152-w5ynbewh	122	40	washing	wash	VBG
cord-289152-w5ynbewh	122	41	with	with	IN
cord-289152-w5ynbewh	122	42	PBS	PBS	NNP
cord-289152-w5ynbewh	122	43	,	,	,
cord-289152-w5ynbewh	122	44	fresh	fresh	JJ
cord-289152-w5ynbewh	122	45	medium	medium	NN
cord-289152-w5ynbewh	122	46	was	be	VBD
cord-289152-w5ynbewh	122	47	added	add	VBN
cord-289152-w5ynbewh	122	48	.	.	.
cord-289152-w5ynbewh	123	1	At	at	IN
cord-289152-w5ynbewh	123	2	24	24	CD
cord-289152-w5ynbewh	123	3	h	h	NN
cord-289152-w5ynbewh	123	4	post	post	NN
cord-289152-w5ynbewh	123	5	-	-	NN
cord-289152-w5ynbewh	123	6	infection	infection	NN
cord-289152-w5ynbewh	123	7	,	,	,
cord-289152-w5ynbewh	123	8	cells	cell	NNS
cord-289152-w5ynbewh	123	9	were	be	VBD
cord-289152-w5ynbewh	123	10	lysed	lyse	VBN
cord-289152-w5ynbewh	123	11	.	.	.
cord-289152-w5ynbewh	124	1	Firefly	Firefly	NNP
cord-289152-w5ynbewh	124	2	and	and	CC
cord-289152-w5ynbewh	124	3	renillar	renillar	JJ
cord-289152-w5ynbewh	124	4	luciferase	luciferase	NN
cord-289152-w5ynbewh	124	5	activities	activity	NNS
cord-289152-w5ynbewh	124	6	were	be	VBD
cord-289152-w5ynbewh	124	7	measured	measure	VBN
cord-289152-w5ynbewh	124	8	by	by	IN
cord-289152-w5ynbewh	124	9	using	use	VBG
cord-289152-w5ynbewh	124	10	a	a	DT
cord-289152-w5ynbewh	124	11	dual	dual	JJ
cord-289152-w5ynbewh	124	12	luciferase	luciferase	NN
cord-289152-w5ynbewh	124	13	reporter	reporter	NN
cord-289152-w5ynbewh	124	14	assay	assay	NN
cord-289152-w5ynbewh	124	15	kit	kit	NN
cord-289152-w5ynbewh	124	16	.	.	.
cord-289152-w5ynbewh	125	1	The	the	DT
cord-289152-w5ynbewh	125	2	luciferase	luciferase	NN
cord-289152-w5ynbewh	125	3	assays	assay	NNS
cord-289152-w5ynbewh	125	4	were	be	VBD
cord-289152-w5ynbewh	125	5	performed	perform	VBN
cord-289152-w5ynbewh	125	6	in	in	IN
cord-289152-w5ynbewh	125	7	triplicate	triplicate	NN
cord-289152-w5ynbewh	125	8	.	.	.
cord-289152-w5ynbewh	126	1	Firefly	Firefly	NNP
cord-289152-w5ynbewh	126	2	luciferase	luciferase	NN
cord-289152-w5ynbewh	126	3	activity	activity	NN
cord-289152-w5ynbewh	126	4	was	be	VBD
cord-289152-w5ynbewh	126	5	normalized	normalize	VBN
cord-289152-w5ynbewh	126	6	by	by	IN
cord-289152-w5ynbewh	126	7	renillar	renillar	JJ
cord-289152-w5ynbewh	126	8	luciferase	luciferase	NN
cord-289152-w5ynbewh	126	9	activity	activity	NN
cord-289152-w5ynbewh	126	10	.	.	.
cord-289152-w5ynbewh	127	1	Results	result	NNS
cord-289152-w5ynbewh	127	2	are	be	VBP
cord-289152-w5ynbewh	127	3	shown	show	VBN
cord-289152-w5ynbewh	127	4	as	as	IN
cord-289152-w5ynbewh	127	5	the	the	DT
cord-289152-w5ynbewh	127	6	relative	relative	JJ
cord-289152-w5ynbewh	127	7	fold	fold	NN
cord-289152-w5ynbewh	127	8	change	change	NN
cord-289152-w5ynbewh	127	9	compared	compare	VBN
cord-289152-w5ynbewh	127	10	to	to	IN
cord-289152-w5ynbewh	127	11	that	that	DT
cord-289152-w5ynbewh	127	12	of	of	IN
cord-289152-w5ynbewh	127	13	mock	mock	JJ
cord-289152-w5ynbewh	127	14	-	-	HYPH
cord-289152-w5ynbewh	127	15	infected	infect	VBN
cord-289152-w5ynbewh	127	16	cells	cell	NNS
cord-289152-w5ynbewh	127	17	.	.	.
cord-289152-w5ynbewh	128	1	The	the	DT
cord-289152-w5ynbewh	128	2	symbol	symbol	NN
cord-289152-w5ynbewh	128	3	c	c	NN
cord-289152-w5ynbewh	128	4	indicates	indicate	VBZ
cord-289152-w5ynbewh	128	5	P	p	NN
cord-289152-w5ynbewh	128	6	<	<	XX
cord-289152-w5ynbewh	128	7	0.001	0.001	CD
cord-289152-w5ynbewh	128	8	for	for	IN
cord-289152-w5ynbewh	128	9	results	result	NNS
cord-289152-w5ynbewh	128	10	from	from	IN
cord-289152-w5ynbewh	128	11	infectious	infectious	JJ
cord-289152-w5ynbewh	128	12	virus	virus	NN
cord-289152-w5ynbewh	128	13	compared	compare	VBN
cord-289152-w5ynbewh	128	14	to	to	IN
cord-289152-w5ynbewh	128	15	mock	mock	VB
cord-289152-w5ynbewh	128	16	-	-	HYPH
cord-289152-w5ynbewh	128	17	infected	infect	VBN
cord-289152-w5ynbewh	128	18	controls	control	NNS
cord-289152-w5ynbewh	128	19	.	.	.
cord-289152-w5ynbewh	129	1	The	the	DT
cord-289152-w5ynbewh	129	2	symbols	symbol	NNS
cord-289152-w5ynbewh	129	3	#	#	$
cord-289152-w5ynbewh	129	4	,	,	,
cord-289152-w5ynbewh	129	5	*	*	NFP
cord-289152-w5ynbewh	129	6	,	,	,
cord-289152-w5ynbewh	129	7	and	and	CC
cord-289152-w5ynbewh	129	8	k	k	NNP
cord-289152-w5ynbewh	129	9	indicate	indicate	VBP
cord-289152-w5ynbewh	129	10	P	p	NN
cord-289152-w5ynbewh	129	11	values	value	NNS
cord-289152-w5ynbewh	129	12	<	<	XX
cord-289152-w5ynbewh	129	13	0.01	0.01	CD
cord-289152-w5ynbewh	129	14	,	,	,
cord-289152-w5ynbewh	129	15	<	<	NNP
cord-289152-w5ynbewh	129	16	0.001	0.001	CD
cord-289152-w5ynbewh	129	17	,	,	,
cord-289152-w5ynbewh	129	18	and	and	CC
cord-289152-w5ynbewh	129	19	<	<	XX
cord-289152-w5ynbewh	129	20	0.05	0.05	CD
cord-289152-w5ynbewh	129	21	,	,	,
cord-289152-w5ynbewh	129	22	respectively	respectively	RB
cord-289152-w5ynbewh	129	23	,	,	,
cord-289152-w5ynbewh	129	24	for	for	IN
cord-289152-w5ynbewh	129	25	results	result	NNS
cord-289152-w5ynbewh	129	26	from	from	IN
cord-289152-w5ynbewh	129	27	UVinactivated	uvinactivated	JJ
cord-289152-w5ynbewh	129	28	virus	virus	NN
cord-289152-w5ynbewh	129	29	compared	compare	VBN
cord-289152-w5ynbewh	129	30	to	to	IN
cord-289152-w5ynbewh	129	31	infectious	infectious	JJ
cord-289152-w5ynbewh	129	32	virus	virus	NN
cord-289152-w5ynbewh	129	33	.	.	.
cord-289152-w5ynbewh	130	1	These	these	DT
cord-289152-w5ynbewh	130	2	results	result	NNS
cord-289152-w5ynbewh	130	3	are	be	VBP
cord-289152-w5ynbewh	130	4	representative	representative	JJ
cord-289152-w5ynbewh	130	5	of	of	IN
cord-289152-w5ynbewh	130	6	at	at	RB
cord-289152-w5ynbewh	130	7	least	least	RBS
cord-289152-w5ynbewh	130	8	three	three	CD
cord-289152-w5ynbewh	130	9	independent	independent	JJ
cord-289152-w5ynbewh	130	10	experiments	experiment	NNS
cord-289152-w5ynbewh	130	11	.	.	.
cord-289152-w5ynbewh	131	1	Each	each	DT
cord-289152-w5ynbewh	131	2	bar	bar	NN
cord-289152-w5ynbewh	131	3	represents	represent	VBZ
cord-289152-w5ynbewh	131	4	the	the	DT
cord-289152-w5ynbewh	131	5	averaged	average	VBN
cord-289152-w5ynbewh	131	6	data	datum	NNS
cord-289152-w5ynbewh	131	7	from	from	IN
cord-289152-w5ynbewh	131	8	one	one	CD
cord-289152-w5ynbewh	131	9	representative	representative	JJ
cord-289152-w5ynbewh	131	10	experiment	experiment	NN
cord-289152-w5ynbewh	131	11	.	.	.
cord-289152-w5ynbewh	132	1	Values	value	NNS
cord-289152-w5ynbewh	132	2	are	be	VBP
cord-289152-w5ynbewh	132	3	shown	show	VBN
cord-289152-w5ynbewh	132	4	as	as	IN
cord-289152-w5ynbewh	132	5	the	the	DT
cord-289152-w5ynbewh	132	6	mean	mean	JJ
cord-289152-w5ynbewh	132	7	T	T	NNP
cord-289152-w5ynbewh	132	8	SD	sd	NN
cord-289152-w5ynbewh	132	9	from	from	IN
cord-289152-w5ynbewh	132	10	triplicate	triplicate	JJ
cord-289152-w5ynbewh	132	11	wells	well	NNS
cord-289152-w5ynbewh	132	12	.	.	.
cord-289152-w5ynbewh	133	1	To	to	TO
cord-289152-w5ynbewh	133	2	determine	determine	VB
cord-289152-w5ynbewh	133	3	if	if	IN
cord-289152-w5ynbewh	133	4	NF	nf	NN
cord-289152-w5ynbewh	133	5	-	-	HYPH
cord-289152-w5ynbewh	133	6	nB	nB	NNP
cord-289152-w5ynbewh	133	7	activation	activation	NN
cord-289152-w5ynbewh	133	8	by	by	IN
cord-289152-w5ynbewh	133	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	133	10	was	be	VBD
cord-289152-w5ynbewh	133	11	dependent	dependent	JJ
cord-289152-w5ynbewh	133	12	on	on	IN
cord-289152-w5ynbewh	133	13	InBa	InBa	NNP
cord-289152-w5ynbewh	133	14	degradation	degradation	NN
cord-289152-w5ynbewh	133	15	in	in	IN
cord-289152-w5ynbewh	133	16	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	133	17	cells	cell	NNS
cord-289152-w5ynbewh	133	18	,	,	,
cord-289152-w5ynbewh	133	19	the	the	DT
cord-289152-w5ynbewh	133	20	NF	nf	NN
cord-289152-w5ynbewh	133	21	-	-	HYPH
cord-289152-w5ynbewh	133	22	nB	nB	NNP
cord-289152-w5ynbewh	133	23	pathway	pathway	NN
cord-289152-w5ynbewh	133	24	was	be	VBD
cord-289152-w5ynbewh	133	25	blocked	block	VBN
cord-289152-w5ynbewh	133	26	by	by	IN
cord-289152-w5ynbewh	133	27	using	use	VBG
cord-289152-w5ynbewh	133	28	an	an	DT
cord-289152-w5ynbewh	133	29	adenovirus	adenovirus	NN
cord-289152-w5ynbewh	133	30	vector	vector	NN
cord-289152-w5ynbewh	133	31	expressing	express	VBG
cord-289152-w5ynbewh	133	32	a	a	DT
cord-289152-w5ynbewh	133	33	dominant	dominant	JJ
cord-289152-w5ynbewh	133	34	negative	negative	JJ
cord-289152-w5ynbewh	133	35	form	form	NN
cord-289152-w5ynbewh	133	36	of	of	IN
cord-289152-w5ynbewh	133	37	InBa	InBa	NNP
cord-289152-w5ynbewh	133	38	(	(	-LRB-
cord-289152-w5ynbewh	133	39	Ad	Ad	NNP
cord-289152-w5ynbewh	133	40	-	-	HYPH
cord-289152-w5ynbewh	133	41	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	133	42	)	)	-RRB-
cord-289152-w5ynbewh	133	43	which	which	WDT
cord-289152-w5ynbewh	133	44	lacks	lack	VBZ
cord-289152-w5ynbewh	133	45	both	both	DT
cord-289152-w5ynbewh	133	46	constitutive	constitutive	JJ
cord-289152-w5ynbewh	133	47	(	(	-LRB-
cord-289152-w5ynbewh	133	48	Barroga	Barroga	NNP
cord-289152-w5ynbewh	133	49	et	et	FW
cord-289152-w5ynbewh	133	50	al	al	NNP
cord-289152-w5ynbewh	133	51	.	.	NNP
cord-289152-w5ynbewh	133	52	,	,	,
cord-289152-w5ynbewh	133	53	1995	1995	CD
cord-289152-w5ynbewh	133	54	)	)	-RRB-
cord-289152-w5ynbewh	133	55	and	and	CC
cord-289152-w5ynbewh	133	56	inducible	inducible	JJ
cord-289152-w5ynbewh	133	57	(	(	-LRB-
cord-289152-w5ynbewh	133	58	Brown	Brown	NNP
cord-289152-w5ynbewh	133	59	et	et	NNP
cord-289152-w5ynbewh	133	60	al	al	NNP
cord-289152-w5ynbewh	133	61	.	.	NNP
cord-289152-w5ynbewh	133	62	,	,	,
cord-289152-w5ynbewh	133	63	1995	1995	CD
cord-289152-w5ynbewh	133	64	)	)	-RRB-
cord-289152-w5ynbewh	133	65	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	133	66	sites	site	NNS
cord-289152-w5ynbewh	133	67	.	.	.
cord-289152-w5ynbewh	134	1	Thus	thus	RB
cord-289152-w5ynbewh	134	2	,	,	,
cord-289152-w5ynbewh	134	3	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	134	4	is	be	VBZ
cord-289152-w5ynbewh	134	5	a	a	DT
cord-289152-w5ynbewh	134	6	potent	potent	JJ
cord-289152-w5ynbewh	134	7	NF	nf	NN
cord-289152-w5ynbewh	134	8	-	-	HYPH
cord-289152-w5ynbewh	134	9	nB	nb	JJ
cord-289152-w5ynbewh	134	10	inhibitor	inhibitor	NN
cord-289152-w5ynbewh	134	11	.	.	.
cord-289152-w5ynbewh	135	1	The	the	DT
cord-289152-w5ynbewh	135	2	same	same	JJ
cord-289152-w5ynbewh	135	3	adenovirus	adenovirus	NN
cord-289152-w5ynbewh	135	4	vector	vector	NN
cord-289152-w5ynbewh	135	5	expressing	express	VBG
cord-289152-w5ynbewh	135	6	GFP	GFP	NNP
cord-289152-w5ynbewh	135	7	(	(	-LRB-
cord-289152-w5ynbewh	135	8	Ad	ad	NN
cord-289152-w5ynbewh	135	9	-	-	HYPH
cord-289152-w5ynbewh	135	10	eGFP	egfp	NN
cord-289152-w5ynbewh	135	11	)	)	-RRB-
cord-289152-w5ynbewh	136	1	instead	instead	RB
cord-289152-w5ynbewh	136	2	of	of	IN
cord-289152-w5ynbewh	136	3	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	136	4	was	be	VBD
cord-289152-w5ynbewh	136	5	used	use	VBN
cord-289152-w5ynbewh	136	6	as	as	IN
cord-289152-w5ynbewh	136	7	a	a	DT
cord-289152-w5ynbewh	136	8	control	control	NN
cord-289152-w5ynbewh	136	9	.	.	.
cord-289152-w5ynbewh	137	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	137	2	cells	cell	NNS
cord-289152-w5ynbewh	137	3	were	be	VBD
cord-289152-w5ynbewh	137	4	infected	infect	VBN
cord-289152-w5ynbewh	137	5	with	with	IN
cord-289152-w5ynbewh	137	6	Ad	ad	NN
cord-289152-w5ynbewh	137	7	-	-	HYPH
cord-289152-w5ynbewh	137	8	eGFP	egfp	NN
cord-289152-w5ynbewh	137	9	or	or	CC
cord-289152-w5ynbewh	137	10	Ad	Ad	NNP
cord-289152-w5ynbewh	137	11	-	-	HYPH
cord-289152-w5ynbewh	137	12	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	137	13	at	at	IN
cord-289152-w5ynbewh	137	14	various	various	JJ
cord-289152-w5ynbewh	137	15	MOIs	MOIs	NNP
cord-289152-w5ynbewh	137	16	(	(	-LRB-
cord-289152-w5ynbewh	137	17	1	1	CD
cord-289152-w5ynbewh	137	18	,	,	,
cord-289152-w5ynbewh	137	19	10	10	CD
cord-289152-w5ynbewh	137	20	,	,	,
cord-289152-w5ynbewh	137	21	or	or	CC
cord-289152-w5ynbewh	137	22	100	100	CD
cord-289152-w5ynbewh	137	23	)	)	-RRB-
cord-289152-w5ynbewh	137	24	for	for	IN
cord-289152-w5ynbewh	137	25	16	16	CD
cord-289152-w5ynbewh	137	26	h	h	NN
cord-289152-w5ynbewh	137	27	and	and	CC
cord-289152-w5ynbewh	137	28	then	then	RB
cord-289152-w5ynbewh	137	29	transfected	transfecte	VBN
cord-289152-w5ynbewh	137	30	with	with	IN
cord-289152-w5ynbewh	137	31	pNF	pNF	NNP
cord-289152-w5ynbewh	137	32	-	-	HYPH
cord-289152-w5ynbewh	137	33	nB	nB	NNP
cord-289152-w5ynbewh	137	34	Luc	Luc	NNP
cord-289152-w5ynbewh	137	35	plasmid	plasmid	NN
cord-289152-w5ynbewh	137	36	and	and	CC
cord-289152-w5ynbewh	137	37	phRG	phRG	NNP
cord-289152-w5ynbewh	137	38	-	-	HYPH
cord-289152-w5ynbewh	137	39	TK	tk	NN
cord-289152-w5ynbewh	137	40	plasmid	plasmid	NN
cord-289152-w5ynbewh	137	41	followed	follow	VBN
cord-289152-w5ynbewh	137	42	by	by	IN
cord-289152-w5ynbewh	137	43	superinfection	superinfection	NN
cord-289152-w5ynbewh	137	44	with	with	IN
cord-289152-w5ynbewh	137	45	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	137	46	at	at	IN
cord-289152-w5ynbewh	137	47	MOI	MOI	NNP
cord-289152-w5ynbewh	137	48	=	=	SYM
cord-289152-w5ynbewh	137	49	0.1	0.1	CD
cord-289152-w5ynbewh	137	50	.	.	.
cord-289152-w5ynbewh	138	1	After	after	IN
cord-289152-w5ynbewh	138	2	48	48	CD
cord-289152-w5ynbewh	138	3	h	h	NN
cord-289152-w5ynbewh	138	4	,	,	,
cord-289152-w5ynbewh	138	5	cells	cell	NNS
cord-289152-w5ynbewh	138	6	were	be	VBD
cord-289152-w5ynbewh	138	7	lysed	lyse	VBN
cord-289152-w5ynbewh	138	8	and	and	CC
cord-289152-w5ynbewh	138	9	analyzed	analyze	VBN
cord-289152-w5ynbewh	138	10	for	for	IN
cord-289152-w5ynbewh	138	11	luciferase	luciferase	JJ
cord-289152-w5ynbewh	138	12	activity	activity	NN
cord-289152-w5ynbewh	138	13	.	.	.
cord-289152-w5ynbewh	139	1	Overexpression	Overexpression	NNP
cord-289152-w5ynbewh	139	2	of	of	IN
cord-289152-w5ynbewh	139	3	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	139	4	significantly	significantly	RB
cord-289152-w5ynbewh	139	5	suppressed	suppress	VBD
cord-289152-w5ynbewh	139	6	constitutive	constitutive	JJ
cord-289152-w5ynbewh	139	7	NF	nf	NN
cord-289152-w5ynbewh	139	8	-	-	HYPH
cord-289152-w5ynbewh	139	9	nB	nb	NN
cord-289152-w5ynbewh	139	10	activity	activity	NN
cord-289152-w5ynbewh	139	11	compared	compare	VBN
cord-289152-w5ynbewh	139	12	to	to	IN
cord-289152-w5ynbewh	139	13	that	that	DT
cord-289152-w5ynbewh	139	14	in	in	IN
cord-289152-w5ynbewh	139	15	the	the	DT
cord-289152-w5ynbewh	139	16	Ad	ad	NN
cord-289152-w5ynbewh	139	17	-	-	HYPH
cord-289152-w5ynbewh	139	18	eGFP	egfp	NN
cord-289152-w5ynbewh	139	19	,	,	,
cord-289152-w5ynbewh	139	20	and	and	CC
cord-289152-w5ynbewh	139	21	such	such	JJ
cord-289152-w5ynbewh	139	22	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	139	23	expressing	express	VBG
cord-289152-w5ynbewh	139	24	cells	cell	NNS
cord-289152-w5ynbewh	139	25	failed	fail	VBD
cord-289152-w5ynbewh	139	26	to	to	TO
cord-289152-w5ynbewh	139	27	activate	activate	VB
cord-289152-w5ynbewh	139	28	NF	NF	NNP
cord-289152-w5ynbewh	139	29	-	-	HYPH
cord-289152-w5ynbewh	139	30	nB	nb	NN
cord-289152-w5ynbewh	139	31	in	in	IN
cord-289152-w5ynbewh	139	32	response	response	NN
cord-289152-w5ynbewh	139	33	to	to	IN
cord-289152-w5ynbewh	139	34	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	139	35	infection	infection	NN
cord-289152-w5ynbewh	140	1	(	(	-LRB-
cord-289152-w5ynbewh	140	2	Fig	Fig	NNP
cord-289152-w5ynbewh	140	3	.	.	NNP
cord-289152-w5ynbewh	140	4	5	5	CD
cord-289152-w5ynbewh	140	5	)	)	-RRB-
cord-289152-w5ynbewh	140	6	.	.	.
cord-289152-w5ynbewh	141	1	It	-PRON-	PRP
cord-289152-w5ynbewh	141	2	was	be	VBD
cord-289152-w5ynbewh	141	3	then	then	RB
cord-289152-w5ynbewh	141	4	determined	determine	VBN
cord-289152-w5ynbewh	141	5	if	if	IN
cord-289152-w5ynbewh	141	6	NF	nf	NN
cord-289152-w5ynbewh	141	7	-	-	HYPH
cord-289152-w5ynbewh	141	8	nB	nB	NNP
cord-289152-w5ynbewh	141	9	was	be	VBD
cord-289152-w5ynbewh	141	10	required	require	VBN
cord-289152-w5ynbewh	141	11	for	for	IN
cord-289152-w5ynbewh	141	12	efficient	efficient	JJ
cord-289152-w5ynbewh	141	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	141	14	replication	replication	NN
cord-289152-w5ynbewh	141	15	.	.	.
cord-289152-w5ynbewh	142	1	Cell	cell	NN
cord-289152-w5ynbewh	142	2	culture	culture	NN
cord-289152-w5ynbewh	142	3	medium	medium	NN
cord-289152-w5ynbewh	142	4	was	be	VBD
cord-289152-w5ynbewh	142	5	collected	collect	VBN
cord-289152-w5ynbewh	142	6	at	at	IN
cord-289152-w5ynbewh	142	7	0	0	CD
cord-289152-w5ynbewh	142	8	,	,	,
cord-289152-w5ynbewh	142	9	5	5	CD
cord-289152-w5ynbewh	142	10	,	,	,
cord-289152-w5ynbewh	142	11	24	24	CD
cord-289152-w5ynbewh	142	12	,	,	,
cord-289152-w5ynbewh	142	13	36	36	CD
cord-289152-w5ynbewh	142	14	,	,	,
cord-289152-w5ynbewh	142	15	and	and	CC
cord-289152-w5ynbewh	142	16	48	48	CD
cord-289152-w5ynbewh	142	17	h	h	NN
cord-289152-w5ynbewh	142	18	p.i	p.i	NNP
cord-289152-w5ynbewh	142	19	.	.	.
cord-289152-w5ynbewh	142	20	Production	production	NN
cord-289152-w5ynbewh	142	21	of	of	IN
cord-289152-w5ynbewh	142	22	infectious	infectious	JJ
cord-289152-w5ynbewh	142	23	progeny	progeny	NN
cord-289152-w5ynbewh	142	24	virus	virus	NN
cord-289152-w5ynbewh	142	25	was	be	VBD
cord-289152-w5ynbewh	142	26	determined	determine	VBN
cord-289152-w5ynbewh	142	27	by	by	IN
cord-289152-w5ynbewh	142	28	serial	serial	JJ
cord-289152-w5ynbewh	142	29	10-fold	10-fold	JJ
cord-289152-w5ynbewh	142	30	dilutions	dilution	NNS
cord-289152-w5ynbewh	142	31	of	of	IN
cord-289152-w5ynbewh	142	32	viral	viral	JJ
cord-289152-w5ynbewh	142	33	stocks	stock	NNS
cord-289152-w5ynbewh	142	34	with	with	IN
cord-289152-w5ynbewh	142	35	50	50	CD
cord-289152-w5ynbewh	142	36	%	%	NN
cord-289152-w5ynbewh	142	37	tissue	tissue	NN
cord-289152-w5ynbewh	142	38	culture	culture	NN
cord-289152-w5ynbewh	142	39	infectious	infectious	JJ
cord-289152-w5ynbewh	142	40	dose	dose	NN
cord-289152-w5ynbewh	142	41	(	(	-LRB-
cord-289152-w5ynbewh	142	42	TCID	TCID	NNP
cord-289152-w5ynbewh	142	43	50	50	CD
cord-289152-w5ynbewh	142	44	)	)	-RRB-
cord-289152-w5ynbewh	142	45	titers	titer	NNS
cord-289152-w5ynbewh	142	46	calculated	calculate	VBN
cord-289152-w5ynbewh	142	47	by	by	IN
cord-289152-w5ynbewh	142	48	the	the	DT
cord-289152-w5ynbewh	142	49	method	method	NN
cord-289152-w5ynbewh	142	50	of	of	IN
cord-289152-w5ynbewh	142	51	Reed	Reed	NNP
cord-289152-w5ynbewh	142	52	and	and	CC
cord-289152-w5ynbewh	142	53	Muench	Muench	NNP
cord-289152-w5ynbewh	142	54	(	(	-LRB-
cord-289152-w5ynbewh	142	55	1938	1938	CD
cord-289152-w5ynbewh	142	56	)	)	-RRB-
cord-289152-w5ynbewh	142	57	on	on	IN
cord-289152-w5ynbewh	142	58	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	142	59	cells	cell	NNS
cord-289152-w5ynbewh	142	60	.	.	.
cord-289152-w5ynbewh	143	1	The	the	DT
cord-289152-w5ynbewh	143	2	results	result	NNS
cord-289152-w5ynbewh	143	3	representing	represent	VBG
cord-289152-w5ynbewh	143	4	three	three	CD
cord-289152-w5ynbewh	143	5	independent	independent	JJ
cord-289152-w5ynbewh	143	6	experiments	experiment	NNS
cord-289152-w5ynbewh	143	7	are	be	VBP
cord-289152-w5ynbewh	143	8	shown	show	VBN
cord-289152-w5ynbewh	143	9	in	in	IN
cord-289152-w5ynbewh	143	10	Fig	Fig	NNP
cord-289152-w5ynbewh	143	11	.	.	.
cord-289152-w5ynbewh	144	1	6	6	LS
cord-289152-w5ynbewh	144	2	.	.	.
cord-289152-w5ynbewh	145	1	The	the	DT
cord-289152-w5ynbewh	145	2	kinetics	kinetic	NNS
cord-289152-w5ynbewh	145	3	of	of	IN
cord-289152-w5ynbewh	145	4	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	145	5	replication	replication	NN
cord-289152-w5ynbewh	145	6	were	be	VBD
cord-289152-w5ynbewh	145	7	compared	compare	VBN
cord-289152-w5ynbewh	145	8	to	to	IN
cord-289152-w5ynbewh	145	9	that	that	DT
cord-289152-w5ynbewh	145	10	in	in	IN
cord-289152-w5ynbewh	145	11	control	control	NN
cord-289152-w5ynbewh	145	12	cells	cell	NNS
cord-289152-w5ynbewh	145	13	.	.	.
cord-289152-w5ynbewh	146	1	The	the	DT
cord-289152-w5ynbewh	146	2	results	result	NNS
cord-289152-w5ynbewh	146	3	showed	show	VBD
cord-289152-w5ynbewh	146	4	that	that	IN
cord-289152-w5ynbewh	146	5	neither	neither	CC
cord-289152-w5ynbewh	146	6	Ad	ad	NN
cord-289152-w5ynbewh	146	7	-	-	HYPH
cord-289152-w5ynbewh	146	8	eGFP	egfp	NN
cord-289152-w5ynbewh	147	1	(	(	-LRB-
cord-289152-w5ynbewh	147	2	Fig	Fig	NNP
cord-289152-w5ynbewh	147	3	.	.	.
cord-289152-w5ynbewh	147	4	6A	6a	CD
cord-289152-w5ynbewh	147	5	)	)	-RRB-
cord-289152-w5ynbewh	147	6	nor	nor	CC
cord-289152-w5ynbewh	147	7	Ad	ad	NN
cord-289152-w5ynbewh	147	8	-	-	HYPH
cord-289152-w5ynbewh	147	9	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	148	1	(	(	-LRB-
cord-289152-w5ynbewh	148	2	Fig	Fig	NNP
cord-289152-w5ynbewh	148	3	.	.	.
cord-289152-w5ynbewh	148	4	6B	6b	CD
cord-289152-w5ynbewh	148	5	)	)	-RRB-
cord-289152-w5ynbewh	148	6	affected	affect	VBD
cord-289152-w5ynbewh	148	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	148	8	replication	replication	NN
cord-289152-w5ynbewh	148	9	in	in	IN
cord-289152-w5ynbewh	148	10	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	148	11	cells	cell	NNS
cord-289152-w5ynbewh	148	12	.	.	.
cord-289152-w5ynbewh	149	1	In	in	IN
cord-289152-w5ynbewh	149	2	addition	addition	NN
cord-289152-w5ynbewh	149	3	,	,	,
cord-289152-w5ynbewh	149	4	a	a	DT
cord-289152-w5ynbewh	149	5	typical	typical	JJ
cord-289152-w5ynbewh	149	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	149	7	-	-	HYPH
cord-289152-w5ynbewh	149	8	induced	induce	VBN
cord-289152-w5ynbewh	149	9	CPE	CPE	NNP
cord-289152-w5ynbewh	149	10	was	be	VBD
cord-289152-w5ynbewh	149	11	observed	observe	VBN
cord-289152-w5ynbewh	149	12	in	in	IN
cord-289152-w5ynbewh	149	13	both	both	CC
cord-289152-w5ynbewh	149	14	Ad	ad	NN
cord-289152-w5ynbewh	149	15	-	-	HYPH
cord-289152-w5ynbewh	149	16	eGFP	egfp	NN
cord-289152-w5ynbewh	149	17	-	-	HYPH
cord-289152-w5ynbewh	149	18	and	and	CC
cord-289152-w5ynbewh	149	19	Ad	Ad	NNP
cord-289152-w5ynbewh	149	20	-	-	HYPH
cord-289152-w5ynbewh	149	21	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	149	22	-	-	HYPH
cord-289152-w5ynbewh	149	23	infected	infect	VBN
cord-289152-w5ynbewh	149	24	cells	cell	NNS
cord-289152-w5ynbewh	149	25	.	.	.
cord-289152-w5ynbewh	150	1	Therefore	therefore	RB
cord-289152-w5ynbewh	150	2	,	,	,
cord-289152-w5ynbewh	150	3	this	this	DT
cord-289152-w5ynbewh	150	4	result	result	NN
cord-289152-w5ynbewh	150	5	showed	show	VBD
cord-289152-w5ynbewh	150	6	that	that	IN
cord-289152-w5ynbewh	150	7	blocking	block	VBG
cord-289152-w5ynbewh	150	8	the	the	DT
cord-289152-w5ynbewh	150	9	NF	nf	NN
cord-289152-w5ynbewh	150	10	-	-	HYPH
cord-289152-w5ynbewh	150	11	nB	nB	NNP
cord-289152-w5ynbewh	150	12	pathway	pathway	NN
cord-289152-w5ynbewh	150	13	by	by	IN
cord-289152-w5ynbewh	150	14	overexpression	overexpression	NN
cord-289152-w5ynbewh	150	15	of	of	IN
cord-289152-w5ynbewh	150	16	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	150	17	does	do	VBZ
cord-289152-w5ynbewh	150	18	not	not	RB
cord-289152-w5ynbewh	150	19	alter	alter	VB
cord-289152-w5ynbewh	150	20	production	production	NN
cord-289152-w5ynbewh	150	21	of	of	IN
cord-289152-w5ynbewh	150	22	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	150	23	progeny	progeny	VBP
cord-289152-w5ynbewh	150	24	viruses	virus	NNS
cord-289152-w5ynbewh	150	25	.	.	.
cord-289152-w5ynbewh	151	1	Intracellular	Intracellular	NNP
cord-289152-w5ynbewh	151	2	ROS	ROS	NNP
cord-289152-w5ynbewh	151	3	production	production	NN
cord-289152-w5ynbewh	151	4	was	be	VBD
cord-289152-w5ynbewh	151	5	detected	detect	VBN
cord-289152-w5ynbewh	151	6	by	by	IN
cord-289152-w5ynbewh	151	7	staining	stain	VBG
cord-289152-w5ynbewh	151	8	with	with	IN
cord-289152-w5ynbewh	151	9	the	the	DT
cord-289152-w5ynbewh	151	10	hydrogen	hydrogen	NN
cord-289152-w5ynbewh	151	11	-	-	HYPH
cord-289152-w5ynbewh	151	12	peroxide	peroxide	NN
cord-289152-w5ynbewh	151	13	-	-	HYPH
cord-289152-w5ynbewh	151	14	sensitive	sensitive	JJ
cord-289152-w5ynbewh	151	15	fluorescent	fluorescent	NN
cord-289152-w5ynbewh	151	16	dye	dye	NN
cord-289152-w5ynbewh	151	17	DCFH	DCFH	NNP
cord-289152-w5ynbewh	151	18	-	-	HYPH
cord-289152-w5ynbewh	151	19	DA	DA	NNP
cord-289152-w5ynbewh	151	20	which	which	WDT
cord-289152-w5ynbewh	151	21	is	be	VBZ
cord-289152-w5ynbewh	151	22	cleaved	cleave	VBN
cord-289152-w5ynbewh	151	23	intracellularly	intracellularly	RB
cord-289152-w5ynbewh	151	24	by	by	IN
cord-289152-w5ynbewh	151	25	nonspecific	nonspecific	JJ
cord-289152-w5ynbewh	151	26	5	5	CD
cord-289152-w5ynbewh	151	27	.	.	.
cord-289152-w5ynbewh	152	1	Degradation	degradation	NN
cord-289152-w5ynbewh	152	2	of	of	IN
cord-289152-w5ynbewh	152	3	InBa	InBa	NNP
cord-289152-w5ynbewh	152	4	is	be	VBZ
cord-289152-w5ynbewh	152	5	required	require	VBN
cord-289152-w5ynbewh	152	6	in	in	IN
cord-289152-w5ynbewh	152	7	NF	nf	NN
cord-289152-w5ynbewh	152	8	-	-	HYPH
cord-289152-w5ynbewh	152	9	nB	nB	NNP
cord-289152-w5ynbewh	152	10	activation	activation	NN
cord-289152-w5ynbewh	152	11	induced	induce	VBN
cord-289152-w5ynbewh	152	12	by	by	IN
cord-289152-w5ynbewh	152	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	152	14	.	.	.
cord-289152-w5ynbewh	153	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	153	2	cells	cell	NNS
cord-289152-w5ynbewh	153	3	were	be	VBD
cord-289152-w5ynbewh	153	4	infected	infect	VBN
cord-289152-w5ynbewh	153	5	with	with	IN
cord-289152-w5ynbewh	153	6	Ad	ad	NN
cord-289152-w5ynbewh	153	7	-	-	HYPH
cord-289152-w5ynbewh	153	8	eGFP	egfp	NN
cord-289152-w5ynbewh	153	9	or	or	CC
cord-289152-w5ynbewh	153	10	Ad	Ad	NNP
cord-289152-w5ynbewh	153	11	-	-	HYPH
cord-289152-w5ynbewh	153	12	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	153	13	at	at	IN
cord-289152-w5ynbewh	153	14	different	different	JJ
cord-289152-w5ynbewh	153	15	MOI	MOI	NNP
cord-289152-w5ynbewh	153	16	for	for	IN
cord-289152-w5ynbewh	153	17	16	16	CD
cord-289152-w5ynbewh	153	18	h	h	NN
cord-289152-w5ynbewh	153	19	and	and	CC
cord-289152-w5ynbewh	153	20	then	then	RB
cord-289152-w5ynbewh	153	21	transfected	transfecte	VBN
cord-289152-w5ynbewh	153	22	with	with	IN
cord-289152-w5ynbewh	153	23	pNF	pNF	NNP
cord-289152-w5ynbewh	153	24	-	-	HYPH
cord-289152-w5ynbewh	153	25	nB	nB	NNP
cord-289152-w5ynbewh	153	26	LUC	LUC	NNP
cord-289152-w5ynbewh	153	27	plasmid	plasmid	NN
cord-289152-w5ynbewh	153	28	and	and	CC
cord-289152-w5ynbewh	153	29	phRG	phRG	NNP
cord-289152-w5ynbewh	153	30	-	-	HYPH
cord-289152-w5ynbewh	153	31	TK	tk	NN
cord-289152-w5ynbewh	153	32	plasmid	plasmid	NN
cord-289152-w5ynbewh	153	33	.	.	.
cord-289152-w5ynbewh	154	1	Cells	cell	NNS
cord-289152-w5ynbewh	154	2	were	be	VBD
cord-289152-w5ynbewh	154	3	then	then	RB
cord-289152-w5ynbewh	154	4	mock	mock	JJ
cord-289152-w5ynbewh	154	5	-	-	HYPH
cord-289152-w5ynbewh	154	6	infected	infect	VBN
cord-289152-w5ynbewh	154	7	or	or	CC
cord-289152-w5ynbewh	154	8	infected	infect	VBN
cord-289152-w5ynbewh	154	9	with	with	IN
cord-289152-w5ynbewh	154	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	154	11	at	at	IN
cord-289152-w5ynbewh	154	12	MOI	MOI	NNP
cord-289152-w5ynbewh	154	13	=	=	SYM
cord-289152-w5ynbewh	154	14	0.1	0.1	CD
cord-289152-w5ynbewh	154	15	.	.	.
cord-289152-w5ynbewh	155	1	At	at	IN
cord-289152-w5ynbewh	155	2	48	48	CD
cord-289152-w5ynbewh	155	3	h	h	NN
cord-289152-w5ynbewh	155	4	p.i	p.i	NNP
cord-289152-w5ynbewh	155	5	.	.	NNP
cord-289152-w5ynbewh	155	6	,	,	,
cord-289152-w5ynbewh	155	7	cells	cell	NNS
cord-289152-w5ynbewh	155	8	were	be	VBD
cord-289152-w5ynbewh	155	9	lysed	lyse	VBN
cord-289152-w5ynbewh	155	10	,	,	,
cord-289152-w5ynbewh	155	11	and	and	CC
cord-289152-w5ynbewh	155	12	lysates	lysate	NNS
cord-289152-w5ynbewh	155	13	were	be	VBD
cord-289152-w5ynbewh	155	14	analyzed	analyze	VBN
cord-289152-w5ynbewh	155	15	for	for	IN
cord-289152-w5ynbewh	155	16	firefly	firefly	NNP
cord-289152-w5ynbewh	155	17	and	and	CC
cord-289152-w5ynbewh	155	18	renillar	renillar	JJ
cord-289152-w5ynbewh	155	19	luciferase	luciferase	NN
cord-289152-w5ynbewh	155	20	activities	activity	NNS
cord-289152-w5ynbewh	155	21	using	use	VBG
cord-289152-w5ynbewh	155	22	a	a	DT
cord-289152-w5ynbewh	155	23	dual	dual	JJ
cord-289152-w5ynbewh	155	24	luciferase	luciferase	NN
cord-289152-w5ynbewh	155	25	reporter	reporter	NN
cord-289152-w5ynbewh	155	26	assay	assay	NN
cord-289152-w5ynbewh	155	27	kit	kit	NN
cord-289152-w5ynbewh	155	28	.	.	.
cord-289152-w5ynbewh	156	1	Firefly	Firefly	NNP
cord-289152-w5ynbewh	156	2	luciferase	luciferase	NN
cord-289152-w5ynbewh	156	3	activity	activity	NN
cord-289152-w5ynbewh	156	4	was	be	VBD
cord-289152-w5ynbewh	156	5	normalized	normalize	VBN
cord-289152-w5ynbewh	156	6	by	by	IN
cord-289152-w5ynbewh	156	7	renillar	renillar	JJ
cord-289152-w5ynbewh	156	8	luciferase	luciferase	NN
cord-289152-w5ynbewh	156	9	activity	activity	NN
cord-289152-w5ynbewh	156	10	.	.	.
cord-289152-w5ynbewh	157	1	Results	result	NNS
cord-289152-w5ynbewh	157	2	are	be	VBP
cord-289152-w5ynbewh	157	3	shown	show	VBN
cord-289152-w5ynbewh	157	4	as	as	IN
cord-289152-w5ynbewh	157	5	the	the	DT
cord-289152-w5ynbewh	157	6	relative	relative	JJ
cord-289152-w5ynbewh	157	7	fold	fold	NN
cord-289152-w5ynbewh	157	8	change	change	NN
cord-289152-w5ynbewh	157	9	compared	compare	VBN
cord-289152-w5ynbewh	157	10	to	to	IN
cord-289152-w5ynbewh	157	11	that	that	DT
cord-289152-w5ynbewh	157	12	of	of	IN
cord-289152-w5ynbewh	157	13	mockinfected	mockinfected	JJ
cord-289152-w5ynbewh	157	14	cells	cell	NNS
cord-289152-w5ynbewh	157	15	.	.	.
cord-289152-w5ynbewh	158	1	For	for	IN
cord-289152-w5ynbewh	158	2	all	all	DT
cord-289152-w5ynbewh	158	3	assays	assay	NNS
cord-289152-w5ynbewh	158	4	,	,	,
cord-289152-w5ynbewh	158	5	analysis	analysis	NN
cord-289152-w5ynbewh	158	6	was	be	VBD
cord-289152-w5ynbewh	158	7	performed	perform	VBN
cord-289152-w5ynbewh	158	8	in	in	IN
cord-289152-w5ynbewh	158	9	triplicate	triplicate	NN
cord-289152-w5ynbewh	158	10	,	,	,
cord-289152-w5ynbewh	158	11	and	and	CC
cord-289152-w5ynbewh	158	12	values	value	NNS
cord-289152-w5ynbewh	158	13	are	be	VBP
cord-289152-w5ynbewh	158	14	shown	show	VBN
cord-289152-w5ynbewh	158	15	as	as	IN
cord-289152-w5ynbewh	158	16	mean	mean	JJ
cord-289152-w5ynbewh	158	17	T	T	NNP
cord-289152-w5ynbewh	158	18	SD	sd	NN
cord-289152-w5ynbewh	158	19	.	.	.
cord-289152-w5ynbewh	159	1	These	these	DT
cord-289152-w5ynbewh	159	2	results	result	NNS
cord-289152-w5ynbewh	159	3	are	be	VBP
cord-289152-w5ynbewh	159	4	representative	representative	JJ
cord-289152-w5ynbewh	159	5	of	of	IN
cord-289152-w5ynbewh	159	6	at	at	RB
cord-289152-w5ynbewh	159	7	least	least	RBS
cord-289152-w5ynbewh	159	8	three	three	CD
cord-289152-w5ynbewh	159	9	independent	independent	JJ
cord-289152-w5ynbewh	159	10	experiments	experiment	NNS
cord-289152-w5ynbewh	159	11	.	.	.
cord-289152-w5ynbewh	160	1	*	*	NFP
cord-289152-w5ynbewh	160	2	P	p	NN
cord-289152-w5ynbewh	160	3	<	<	XX
cord-289152-w5ynbewh	160	4	0.001	0.001	CD
cord-289152-w5ynbewh	160	5	.	.	.
cord-289152-w5ynbewh	161	1	esterases	esterases	NNP
cord-289152-w5ynbewh	161	2	to	to	TO
cord-289152-w5ynbewh	161	3	form	form	VB
cord-289152-w5ynbewh	161	4	DCFH	DCFH	NNP
cord-289152-w5ynbewh	161	5	.	.	.
cord-289152-w5ynbewh	162	1	ROS	ROS	NNP
cord-289152-w5ynbewh	162	2	in	in	IN
cord-289152-w5ynbewh	162	3	the	the	DT
cord-289152-w5ynbewh	162	4	cells	cell	NNS
cord-289152-w5ynbewh	162	5	then	then	RB
cord-289152-w5ynbewh	162	6	oxidizes	oxidize	VBZ
cord-289152-w5ynbewh	162	7	DCFH	DCFH	NNP
cord-289152-w5ynbewh	162	8	to	to	TO
cord-289152-w5ynbewh	162	9	form	form	VB
cord-289152-w5ynbewh	162	10	the	the	DT
cord-289152-w5ynbewh	162	11	fluorescent	fluorescent	JJ
cord-289152-w5ynbewh	162	12	product	product	NN
cord-289152-w5ynbewh	162	13	DCF	DCF	NNP
cord-289152-w5ynbewh	162	14	(	(	-LRB-
cord-289152-w5ynbewh	162	15	Sawada	Sawada	NNP
cord-289152-w5ynbewh	162	16	et	et	NNP
cord-289152-w5ynbewh	162	17	al	al	NNP
cord-289152-w5ynbewh	162	18	.	.	NNP
cord-289152-w5ynbewh	162	19	,	,	,
cord-289152-w5ynbewh	162	20	1996	1996	CD
cord-289152-w5ynbewh	162	21	)	)	-RRB-
cord-289152-w5ynbewh	162	22	.	.	.
cord-289152-w5ynbewh	163	1	As	as	IN
cord-289152-w5ynbewh	163	2	shown	show	VBN
cord-289152-w5ynbewh	163	3	in	in	IN
cord-289152-w5ynbewh	163	4	Fig	Fig	NNP
cord-289152-w5ynbewh	163	5	.	.	.
cord-289152-w5ynbewh	164	1	7A	7a	NN
cord-289152-w5ynbewh	164	2	,	,	,
cord-289152-w5ynbewh	165	1	DCF	DCF	NNP
cord-289152-w5ynbewh	165	2	fluorescence	fluorescence	NN
cord-289152-w5ynbewh	165	3	was	be	VBD
cord-289152-w5ynbewh	165	4	enhanced	enhance	VBN
cord-289152-w5ynbewh	165	5	in	in	IN
cord-289152-w5ynbewh	165	6	cells	cell	NNS
cord-289152-w5ynbewh	165	7	infected	infect	VBN
cord-289152-w5ynbewh	165	8	with	with	IN
cord-289152-w5ynbewh	165	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	165	10	at	at	IN
cord-289152-w5ynbewh	165	11	48	48	CD
cord-289152-w5ynbewh	165	12	h	h	NN
cord-289152-w5ynbewh	165	13	p.i	p.i	NNP
cord-289152-w5ynbewh	165	14	,	,	,
cord-289152-w5ynbewh	165	15	suggesting	suggest	VBG
cord-289152-w5ynbewh	165	16	that	that	IN
cord-289152-w5ynbewh	165	17	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	165	18	induced	induce	VBD
cord-289152-w5ynbewh	165	19	ROS	ROS	NNP
cord-289152-w5ynbewh	165	20	production	production	NN
cord-289152-w5ynbewh	165	21	in	in	IN
cord-289152-w5ynbewh	165	22	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	165	23	cells	cell	NNS
cord-289152-w5ynbewh	165	24	.	.	.
cord-289152-w5ynbewh	166	1	To	to	TO
cord-289152-w5ynbewh	166	2	determine	determine	VB
cord-289152-w5ynbewh	166	3	if	if	IN
cord-289152-w5ynbewh	166	4	ROS	ROS	NNP
cord-289152-w5ynbewh	166	5	induction	induction	NN
cord-289152-w5ynbewh	166	6	by	by	IN
cord-289152-w5ynbewh	166	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	166	8	contributed	contribute	VBD
cord-289152-w5ynbewh	166	9	to	to	IN
cord-289152-w5ynbewh	166	10	activation	activation	NN
cord-289152-w5ynbewh	166	11	of	of	IN
cord-289152-w5ynbewh	166	12	NF	nf	NN
cord-289152-w5ynbewh	166	13	-	-	HYPH
cord-289152-w5ynbewh	166	14	nB	nB	NNP
cord-289152-w5ynbewh	166	15	,	,	,
cord-289152-w5ynbewh	166	16	cells	cell	NNS
cord-289152-w5ynbewh	166	17	were	be	VBD
cord-289152-w5ynbewh	166	18	treated	treat	VBN
cord-289152-w5ynbewh	166	19	with	with	IN
cord-289152-w5ynbewh	166	20	antioxidants	antioxidant	NNS
cord-289152-w5ynbewh	166	21	and	and	CC
cord-289152-w5ynbewh	166	22	NF	nf	NN
cord-289152-w5ynbewh	166	23	-	-	HYPH
cord-289152-w5ynbewh	166	24	nB	nb	NN
cord-289152-w5ynbewh	166	25	binding	bind	VBG
cord-289152-w5ynbewh	166	26	activity	activity	NN
cord-289152-w5ynbewh	166	27	was	be	VBD
cord-289152-w5ynbewh	166	28	measured	measure	VBN
cord-289152-w5ynbewh	166	29	at	at	IN
cord-289152-w5ynbewh	166	30	48	48	CD
cord-289152-w5ynbewh	166	31	h	h	NN
cord-289152-w5ynbewh	166	32	p.i	p.i	NNP
cord-289152-w5ynbewh	166	33	.	.	.
cord-289152-w5ynbewh	167	1	The	the	DT
cord-289152-w5ynbewh	167	2	DNA	dna	NN
cord-289152-w5ynbewh	167	3	binding	binding	NN
cord-289152-w5ynbewh	167	4	activity	activity	NN
cord-289152-w5ynbewh	167	5	of	of	IN
cord-289152-w5ynbewh	167	6	NF	nf	NN
cord-289152-w5ynbewh	167	7	-	-	:
cord-289152-w5ynbewh	167	8	nB	nB	NNP
cord-289152-w5ynbewh	167	9	p65	p65	NN
cord-289152-w5ynbewh	167	10	was	be	VBD
cord-289152-w5ynbewh	167	11	markedly	markedly	RB
cord-289152-w5ynbewh	167	12	reduced	reduce	VBN
cord-289152-w5ynbewh	167	13	in	in	IN
cord-289152-w5ynbewh	167	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	167	15	-	-	HYPH
cord-289152-w5ynbewh	167	16	infected	infect	VBN
cord-289152-w5ynbewh	167	17	cells	cell	NNS
cord-289152-w5ynbewh	167	18	when	when	WRB
cord-289152-w5ynbewh	167	19	treated	treat	VBN
cord-289152-w5ynbewh	167	20	with	with	IN
cord-289152-w5ynbewh	167	21	the	the	DT
cord-289152-w5ynbewh	167	22	antioxidant	antioxidant	JJ
cord-289152-w5ynbewh	167	23	PDTC	PDTC	NNP
cord-289152-w5ynbewh	167	24	or	or	CC
cord-289152-w5ynbewh	167	25	NAC	NAC	NNP
cord-289152-w5ynbewh	167	26	as	as	IN
cord-289152-w5ynbewh	167	27	shown	show	VBN
cord-289152-w5ynbewh	167	28	in	in	IN
cord-289152-w5ynbewh	167	29	Fig	Fig	NNP
cord-289152-w5ynbewh	167	30	.	.	.
cord-289152-w5ynbewh	168	1	7B	7B	NNP
cord-289152-w5ynbewh	168	2	.	.	.
cord-289152-w5ynbewh	169	1	The	the	DT
cord-289152-w5ynbewh	169	2	highest	high	JJS
cord-289152-w5ynbewh	169	3	concentration	concentration	NN
cord-289152-w5ynbewh	169	4	of	of	IN
cord-289152-w5ynbewh	169	5	PDTC	PDTC	NNP
cord-289152-w5ynbewh	169	6	or	or	CC
cord-289152-w5ynbewh	169	7	NAC	NAC	NNP
cord-289152-w5ynbewh	169	8	used	use	VBN
cord-289152-w5ynbewh	169	9	in	in	IN
cord-289152-w5ynbewh	169	10	this	this	DT
cord-289152-w5ynbewh	169	11	experiment	experiment	NN
cord-289152-w5ynbewh	169	12	reduced	reduce	VBN
cord-289152-w5ynbewh	169	13	NF	nf	NN
cord-289152-w5ynbewh	169	14	-	-	HYPH
cord-289152-w5ynbewh	169	15	nB	nb	NN
cord-289152-w5ynbewh	169	16	activity	activity	NN
cord-289152-w5ynbewh	169	17	to	to	IN
cord-289152-w5ynbewh	169	18	less	less	JJR
cord-289152-w5ynbewh	169	19	than	than	IN
cord-289152-w5ynbewh	169	20	30	30	CD
cord-289152-w5ynbewh	169	21	%	%	NN
cord-289152-w5ynbewh	169	22	in	in	IN
cord-289152-w5ynbewh	169	23	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	169	24	-	-	HYPH
cord-289152-w5ynbewh	169	25	infected	infect	VBN
cord-289152-w5ynbewh	169	26	cells	cell	NNS
cord-289152-w5ynbewh	169	27	.	.	.
cord-289152-w5ynbewh	170	1	To	to	TO
cord-289152-w5ynbewh	170	2	rule	rule	VB
cord-289152-w5ynbewh	170	3	out	out	RP
cord-289152-w5ynbewh	170	4	that	that	IN
cord-289152-w5ynbewh	170	5	the	the	DT
cord-289152-w5ynbewh	170	6	observed	observed	JJ
cord-289152-w5ynbewh	170	7	effect	effect	NN
cord-289152-w5ynbewh	170	8	is	be	VBZ
cord-289152-w5ynbewh	170	9	simply	simply	RB
cord-289152-w5ynbewh	170	10	due	due	JJ
cord-289152-w5ynbewh	170	11	to	to	IN
cord-289152-w5ynbewh	170	12	inhibition	inhibition	NN
cord-289152-w5ynbewh	170	13	of	of	IN
cord-289152-w5ynbewh	170	14	viral	viral	JJ
cord-289152-w5ynbewh	170	15	replication	replication	NN
cord-289152-w5ynbewh	170	16	by	by	IN
cord-289152-w5ynbewh	170	17	antioxidants	antioxidant	NNS
cord-289152-w5ynbewh	170	18	,	,	,
cord-289152-w5ynbewh	170	19	virus	virus	NN
cord-289152-w5ynbewh	170	20	titer	titer	NN
cord-289152-w5ynbewh	170	21	was	be	VBD
cord-289152-w5ynbewh	170	22	determined	determine	VBN
cord-289152-w5ynbewh	170	23	at	at	IN
cord-289152-w5ynbewh	170	24	24	24	CD
cord-289152-w5ynbewh	170	25	and	and	CC
cord-289152-w5ynbewh	170	26	48	48	CD
cord-289152-w5ynbewh	170	27	h	h	NN
cord-289152-w5ynbewh	170	28	p.i	p.i	NNP
cord-289152-w5ynbewh	170	29	.	.	.
cord-289152-w5ynbewh	171	1	(	(	-LRB-
cord-289152-w5ynbewh	171	2	Fig	Fig	NNP
cord-289152-w5ynbewh	171	3	.	.	.
cord-289152-w5ynbewh	171	4	7C	7C	NNP
cord-289152-w5ynbewh	171	5	)	)	-RRB-
cord-289152-w5ynbewh	171	6	.	.	.
cord-289152-w5ynbewh	172	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	172	2	replication	replication	NN
cord-289152-w5ynbewh	172	3	was	be	VBD
cord-289152-w5ynbewh	172	4	not	not	RB
cord-289152-w5ynbewh	172	5	significantly	significantly	RB
cord-289152-w5ynbewh	172	6	affected	affect	VBN
cord-289152-w5ynbewh	172	7	by	by	IN
cord-289152-w5ynbewh	172	8	either	either	DT
cord-289152-w5ynbewh	172	9	PDTC	PDTC	NNP
cord-289152-w5ynbewh	172	10	or	or	CC
cord-289152-w5ynbewh	172	11	NAC	NAC	NNP
cord-289152-w5ynbewh	172	12	in	in	IN
cord-289152-w5ynbewh	172	13	all	all	DT
cord-289152-w5ynbewh	172	14	concentration	concentration	NN
cord-289152-w5ynbewh	172	15	tested	test	VBN
cord-289152-w5ynbewh	172	16	.	.	.
cord-289152-w5ynbewh	172	17	 	 	_SP
cord-289152-w5ynbewh	173	1	To	to	TO
cord-289152-w5ynbewh	173	2	investigate	investigate	VB
cord-289152-w5ynbewh	173	3	a	a	DT
cord-289152-w5ynbewh	173	4	possible	possible	JJ
cord-289152-w5ynbewh	173	5	biological	biological	JJ
cord-289152-w5ynbewh	173	6	role	role	NN
cord-289152-w5ynbewh	173	7	of	of	IN
cord-289152-w5ynbewh	173	8	NF	nf	NN
cord-289152-w5ynbewh	173	9	-	-	HYPH
cord-289152-w5ynbewh	173	10	nB	nB	NNP
cord-289152-w5ynbewh	173	11	activation	activation	NN
cord-289152-w5ynbewh	173	12	in	in	IN
cord-289152-w5ynbewh	173	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	173	14	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	173	15	,	,	,
cord-289152-w5ynbewh	173	16	mRNA	mrna	NN
cord-289152-w5ynbewh	173	17	expression	expression	NN
cord-289152-w5ynbewh	173	18	of	of	IN
cord-289152-w5ynbewh	173	19	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	173	20	and	and	CC
cord-289152-w5ynbewh	173	21	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	173	22	which	which	WDT
cord-289152-w5ynbewh	173	23	are	be	VBP
cord-289152-w5ynbewh	173	24	regulated	regulate	VBN
cord-289152-w5ynbewh	173	25	by	by	IN
cord-289152-w5ynbewh	173	26	NF	NF	NNP
cord-289152-w5ynbewh	173	27	-	-	HYPH
cord-289152-w5ynbewh	173	28	nB	nB	NNP
cord-289152-w5ynbewh	173	29	were	be	VBD
cord-289152-w5ynbewh	173	30	determined	determine	VBN
cord-289152-w5ynbewh	173	31	at	at	IN
cord-289152-w5ynbewh	173	32	48	48	CD
cord-289152-w5ynbewh	173	33	h	h	NN
cord-289152-w5ynbewh	173	34	p.i	p.i	NNP
cord-289152-w5ynbewh	173	35	.	.	.
cord-289152-w5ynbewh	174	1	As	as	IN
cord-289152-w5ynbewh	174	2	shown	show	VBN
cord-289152-w5ynbewh	174	3	in	in	IN
cord-289152-w5ynbewh	174	4	Fig	Fig	NNP
cord-289152-w5ynbewh	174	5	.	.	.
cord-289152-w5ynbewh	175	1	8	8	CD
cord-289152-w5ynbewh	175	2	,	,	,
cord-289152-w5ynbewh	175	3	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	175	4	and	and	CC
cord-289152-w5ynbewh	175	5	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	175	6	gene	gene	NN
cord-289152-w5ynbewh	175	7	expression	expression	NN
cord-289152-w5ynbewh	175	8	were	be	VBD
cord-289152-w5ynbewh	175	9	significantly	significantly	RB
cord-289152-w5ynbewh	175	10	enhanced	enhance	VBN
cord-289152-w5ynbewh	175	11	by	by	IN
cord-289152-w5ynbewh	175	12	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	175	13	infection	infection	NN
cord-289152-w5ynbewh	175	14	which	which	WDT
cord-289152-w5ynbewh	175	15	increased	increase	VBD
cord-289152-w5ynbewh	175	16	expression	expression	NN
cord-289152-w5ynbewh	175	17	by	by	IN
cord-289152-w5ynbewh	175	18	approximately	approximately	RB
cord-289152-w5ynbewh	175	19	13-and	13-and	CD
cord-289152-w5ynbewh	175	20	10-fold	10-fold	CD
cord-289152-w5ynbewh	175	21	,	,	,
cord-289152-w5ynbewh	175	22	respectively	respectively	RB
cord-289152-w5ynbewh	175	23	.	.	.
cord-289152-w5ynbewh	176	1	Overexpression	Overexpression	NNP
cord-289152-w5ynbewh	176	2	of	of	IN
cord-289152-w5ynbewh	176	3	InBaDN	InBaDN	NNP
cord-289152-w5ynbewh	176	4	completely	completely	RB
cord-289152-w5ynbewh	176	5	blocked	block	VBD
cord-289152-w5ynbewh	176	6	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	176	7	and	and	CC
cord-289152-w5ynbewh	176	8	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	176	9	gene	gene	NN
cord-289152-w5ynbewh	176	10	expression	expression	NN
cord-289152-w5ynbewh	176	11	.	.	.
cord-289152-w5ynbewh	177	1	Therefore	therefore	RB
cord-289152-w5ynbewh	177	2	,	,	,
cord-289152-w5ynbewh	177	3	these	these	DT
cord-289152-w5ynbewh	177	4	data	datum	NNS
cord-289152-w5ynbewh	177	5	indicate	indicate	VBP
cord-289152-w5ynbewh	177	6	that	that	IN
cord-289152-w5ynbewh	177	7	the	the	DT
cord-289152-w5ynbewh	177	8	activation	activation	NN
cord-289152-w5ynbewh	177	9	of	of	IN
cord-289152-w5ynbewh	177	10	the	the	DT
cord-289152-w5ynbewh	177	11	NF	nf	NN
cord-289152-w5ynbewh	177	12	-	-	HYPH
cord-289152-w5ynbewh	177	13	nB	nB	NNP
cord-289152-w5ynbewh	177	14	pathway	pathway	NN
cord-289152-w5ynbewh	177	15	by	by	IN
cord-289152-w5ynbewh	177	16	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	177	17	was	be	VBD
cord-289152-w5ynbewh	177	18	necessary	necessary	JJ
cord-289152-w5ynbewh	177	19	for	for	IN
cord-289152-w5ynbewh	177	20	enhanced	enhance	VBN
cord-289152-w5ynbewh	177	21	mRNA	mrna	NN
cord-289152-w5ynbewh	177	22	expressions	expression	NNS
cord-289152-w5ynbewh	177	23	of	of	IN
cord-289152-w5ynbewh	177	24	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	177	25	and	and	CC
cord-289152-w5ynbewh	177	26	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	177	27	.	.	.
cord-289152-w5ynbewh	178	1	Virus	virus	NN
cord-289152-w5ynbewh	178	2	-host	-host	NN
cord-289152-w5ynbewh	178	3	interactions	interaction	NNS
cord-289152-w5ynbewh	178	4	lead	lead	VBP
cord-289152-w5ynbewh	178	5	to	to	IN
cord-289152-w5ynbewh	178	6	both	both	DT
cord-289152-w5ynbewh	178	7	activation	activation	NN
cord-289152-w5ynbewh	178	8	and	and	CC
cord-289152-w5ynbewh	178	9	inhibition	inhibition	NN
cord-289152-w5ynbewh	178	10	of	of	IN
cord-289152-w5ynbewh	178	11	complex	complex	JJ
cord-289152-w5ynbewh	178	12	cellular	cellular	JJ
cord-289152-w5ynbewh	178	13	pathways	pathway	NNS
cord-289152-w5ynbewh	178	14	,	,	,
cord-289152-w5ynbewh	178	15	resulting	result	VBG
cord-289152-w5ynbewh	178	16	in	in	IN
cord-289152-w5ynbewh	178	17	antiviral	antiviral	JJ
cord-289152-w5ynbewh	178	18	responses	response	NNS
cord-289152-w5ynbewh	178	19	as	as	RB
cord-289152-w5ynbewh	178	20	well	well	RB
cord-289152-w5ynbewh	178	21	as	as	IN
cord-289152-w5ynbewh	178	22	enhanced	enhance	VBN
cord-289152-w5ynbewh	178	23	viral	viral	JJ
cord-289152-w5ynbewh	178	24	replication	replication	NN
cord-289152-w5ynbewh	178	25	and	and	CC
cord-289152-w5ynbewh	178	26	virulence	virulence	NN
cord-289152-w5ynbewh	178	27	.	.	.
cord-289152-w5ynbewh	179	1	Despite	despite	IN
cord-289152-w5ynbewh	179	2	years	year	NNS
cord-289152-w5ynbewh	179	3	of	of	IN
cord-289152-w5ynbewh	179	4	research	research	NN
cord-289152-w5ynbewh	179	5	,	,	,
cord-289152-w5ynbewh	179	6	little	little	JJ
cord-289152-w5ynbewh	179	7	is	be	VBZ
cord-289152-w5ynbewh	179	8	known	know	VBN
cord-289152-w5ynbewh	179	9	about	about	IN
cord-289152-w5ynbewh	179	10	intracellular	intracellular	JJ
cord-289152-w5ynbewh	179	11	signaling	signal	VBG
cord-289152-w5ynbewh	179	12	pathways	pathway	NNS
cord-289152-w5ynbewh	179	13	that	that	WDT
cord-289152-w5ynbewh	179	14	play	play	VBP
cord-289152-w5ynbewh	179	15	key	key	JJ
cord-289152-w5ynbewh	179	16	roles	role	NNS
cord-289152-w5ynbewh	179	17	after	after	IN
cord-289152-w5ynbewh	179	18	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	179	19	infection	infection	NN
cord-289152-w5ynbewh	179	20	and	and	CC
cord-289152-w5ynbewh	179	21	the	the	DT
cord-289152-w5ynbewh	179	22	role	role	NN
cord-289152-w5ynbewh	179	23	of	of	IN
cord-289152-w5ynbewh	179	24	these	these	DT
cord-289152-w5ynbewh	179	25	pathways	pathway	NNS
cord-289152-w5ynbewh	179	26	in	in	IN
cord-289152-w5ynbewh	179	27	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	179	28	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	179	29	.	.	.
cord-289152-w5ynbewh	180	1	The	the	DT
cord-289152-w5ynbewh	180	2	present	present	JJ
cord-289152-w5ynbewh	180	3	study	study	NN
cord-289152-w5ynbewh	180	4	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	180	5	for	for	IN
cord-289152-w5ynbewh	180	6	the	the	DT
cord-289152-w5ynbewh	180	7	first	first	JJ
cord-289152-w5ynbewh	180	8	time	time	NN
cord-289152-w5ynbewh	180	9	that	that	IN
cord-289152-w5ynbewh	180	10	a	a	DT
cord-289152-w5ynbewh	180	11	virus	virus	NN
cord-289152-w5ynbewh	180	12	belonging	belong	VBG
cord-289152-w5ynbewh	180	13	to	to	IN
cord-289152-w5ynbewh	180	14	the	the	DT
cord-289152-w5ynbewh	180	15	Arteriviridae	Arteriviridae	NNP
cord-289152-w5ynbewh	180	16	family	family	NN
cord-289152-w5ynbewh	180	17	activates	activate	VBZ
cord-289152-w5ynbewh	180	18	NF	NF	NNP
cord-289152-w5ynbewh	180	19	-	-	HYPH
cord-289152-w5ynbewh	180	20	nB	nB	NNP
cord-289152-w5ynbewh	180	21	in	in	IN
cord-289152-w5ynbewh	180	22	host	host	NN
cord-289152-w5ynbewh	180	23	cells	cell	NNS
cord-289152-w5ynbewh	180	24	and	and	CC
cord-289152-w5ynbewh	180	25	that	that	IN
cord-289152-w5ynbewh	180	26	potential	potential	JJ
cord-289152-w5ynbewh	180	27	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	180	28	of	of	IN
cord-289152-w5ynbewh	180	29	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	180	30	-	-	HYPH
cord-289152-w5ynbewh	180	31	mediated	mediate	VBN
cord-289152-w5ynbewh	180	32	NF	nf	NN
cord-289152-w5ynbewh	180	33	-	-	HYPH
cord-289152-w5ynbewh	180	34	nB	nB	NNP
cord-289152-w5ynbewh	180	35	activation	activation	NN
cord-289152-w5ynbewh	180	36	are	be	VBP
cord-289152-w5ynbewh	180	37	derived	derive	VBN
cord-289152-w5ynbewh	180	38	from	from	IN
cord-289152-w5ynbewh	180	39	the	the	DT
cord-289152-w5ynbewh	180	40	InB	inb	NN
cord-289152-w5ynbewh	180	41	protein	protein	NN
cord-289152-w5ynbewh	180	42	degradation	degradation	NN
cord-289152-w5ynbewh	180	43	and	and	CC
cord-289152-w5ynbewh	180	44	ROS	ROS	NNP
cord-289152-w5ynbewh	180	45	induction	induction	NN
cord-289152-w5ynbewh	180	46	.	.	.
cord-289152-w5ynbewh	181	1	The	the	DT
cord-289152-w5ynbewh	181	2	major	major	JJ
cord-289152-w5ynbewh	181	3	target	target	NN
cord-289152-w5ynbewh	181	4	cells	cell	NNS
cord-289152-w5ynbewh	181	5	of	of	IN
cord-289152-w5ynbewh	181	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	181	7	in	in	IN
cord-289152-w5ynbewh	181	8	vivo	vivo	NN
cord-289152-w5ynbewh	181	9	are	be	VBP
cord-289152-w5ynbewh	181	10	tissue	tissue	NN
cord-289152-w5ynbewh	181	11	macrophages	macrophage	NNS
cord-289152-w5ynbewh	181	12	such	such	JJ
cord-289152-w5ynbewh	181	13	as	as	IN
cord-289152-w5ynbewh	181	14	PAMs	pam	NNS
cord-289152-w5ynbewh	181	15	.	.	.
cord-289152-w5ynbewh	182	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	182	2	cells	cell	NNS
cord-289152-w5ynbewh	182	3	are	be	VBP
cord-289152-w5ynbewh	182	4	the	the	DT
cord-289152-w5ynbewh	182	5	only	only	JJ
cord-289152-w5ynbewh	182	6	continuous	continuous	JJ
cord-289152-w5ynbewh	182	7	cell	cell	NN
cord-289152-w5ynbewh	182	8	line	line	NN
cord-289152-w5ynbewh	182	9	that	that	WDT
cord-289152-w5ynbewh	182	10	is	be	VBZ
cord-289152-w5ynbewh	182	11	highly	highly	RB
cord-289152-w5ynbewh	182	12	permissive	permissive	JJ
cord-289152-w5ynbewh	182	13	for	for	IN
cord-289152-w5ynbewh	182	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	182	15	infection	infection	NN
cord-289152-w5ynbewh	183	1	(	(	-LRB-
cord-289152-w5ynbewh	183	2	Kim	Kim	NNP
cord-289152-w5ynbewh	183	3	et	et	NNP
cord-289152-w5ynbewh	183	4	al	al	NNP
cord-289152-w5ynbewh	183	5	.	.	NNP
cord-289152-w5ynbewh	183	6	,	,	,
cord-289152-w5ynbewh	183	7	1993	1993	CD
cord-289152-w5ynbewh	183	8	)	)	-RRB-
cord-289152-w5ynbewh	183	9	,	,	,
cord-289152-w5ynbewh	183	10	and	and	CC
cord-289152-w5ynbewh	184	1	they	-PRON-	PRP
cord-289152-w5ynbewh	184	2	are	be	VBP
cord-289152-w5ynbewh	184	3	typically	typically	RB
cord-289152-w5ynbewh	184	4	used	use	VBN
cord-289152-w5ynbewh	184	5	for	for	IN
cord-289152-w5ynbewh	184	6	in	in	FW
cord-289152-w5ynbewh	184	7	vitro	vitro	FW
cord-289152-w5ynbewh	184	8	experiments	experiment	NNS
cord-289152-w5ynbewh	184	9	of	of	IN
cord-289152-w5ynbewh	184	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	184	11	as	as	RB
cord-289152-w5ynbewh	184	12	well	well	RB
cord-289152-w5ynbewh	184	13	as	as	IN
cord-289152-w5ynbewh	184	14	virus	virus	NN
cord-289152-w5ynbewh	184	15	maintenance	maintenance	NN
cord-289152-w5ynbewh	184	16	and	and	CC
cord-289152-w5ynbewh	184	17	attenuation	attenuation	NN
cord-289152-w5ynbewh	184	18	in	in	IN
cord-289152-w5ynbewh	184	19	the	the	DT
cord-289152-w5ynbewh	184	20	laboratory	laboratory	NN
cord-289152-w5ynbewh	184	21	.	.	.
cord-289152-w5ynbewh	185	1	Viruses	virus	NNS
cord-289152-w5ynbewh	185	2	could	could	MD
cord-289152-w5ynbewh	185	3	have	have	VB
cord-289152-w5ynbewh	185	4	different	different	JJ
cord-289152-w5ynbewh	185	5	effects	effect	NNS
cord-289152-w5ynbewh	185	6	on	on	IN
cord-289152-w5ynbewh	185	7	NF	nf	NN
cord-289152-w5ynbewh	185	8	-	-	HYPH
cord-289152-w5ynbewh	185	9	nB	nB	NNP
cord-289152-w5ynbewh	185	10	pathways	pathway	NNS
cord-289152-w5ynbewh	185	11	depending	depend	VBG
cord-289152-w5ynbewh	185	12	on	on	IN
cord-289152-w5ynbewh	185	13	the	the	DT
cord-289152-w5ynbewh	185	14	cell	cell	NN
cord-289152-w5ynbewh	185	15	type	type	NN
cord-289152-w5ynbewh	185	16	infected	infect	VBN
cord-289152-w5ynbewh	185	17	as	as	IN
cord-289152-w5ynbewh	185	18	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	185	19	in	in	IN
cord-289152-w5ynbewh	185	20	Epstein	Epstein	NNP
cord-289152-w5ynbewh	185	21	-	-	HYPH
cord-289152-w5ynbewh	185	22	Barr	Barr	NNP
cord-289152-w5ynbewh	185	23	virus	virus	NN
cord-289152-w5ynbewh	185	24	and	and	CC
cord-289152-w5ynbewh	185	25	measles	measles	NN
cord-289152-w5ynbewh	185	26	virus	virus	NN
cord-289152-w5ynbewh	185	27	infection	infection	NN
cord-289152-w5ynbewh	185	28	(	(	-LRB-
cord-289152-w5ynbewh	185	29	Devergne	Devergne	NNP
cord-289152-w5ynbewh	185	30	et	et	FW
cord-289152-w5ynbewh	185	31	al	al	NNP
cord-289152-w5ynbewh	185	32	.	.	NNP
cord-289152-w5ynbewh	185	33	,	,	,
cord-289152-w5ynbewh	185	34	1996	1996	CD
cord-289152-w5ynbewh	185	35	;	;	.
cord-289152-w5ynbewh	186	1	Dhib	Dhib	NNP
cord-289152-w5ynbewh	186	2	-	-	HYPH
cord-289152-w5ynbewh	186	3	Jalbut	Jalbut	NNP
cord-289152-w5ynbewh	186	4	et	et	NNP
cord-289152-w5ynbewh	186	5	al	al	NNP
cord-289152-w5ynbewh	186	6	.	.	.
cord-289152-w5ynbewh	187	1	,	,	,
cord-289152-w5ynbewh	187	2	1999	1999	CD
cord-289152-w5ynbewh	187	3	;	;	:
cord-289152-w5ynbewh	187	4	Dreyfus	Dreyfus	NNP
cord-289152-w5ynbewh	187	5	et	et	NNP
cord-289152-w5ynbewh	187	6	al	al	NNP
cord-289152-w5ynbewh	187	7	.	.	.
cord-289152-w5ynbewh	188	1	,	,	,
cord-289152-w5ynbewh	188	2	1999	1999	CD
cord-289152-w5ynbewh	188	3	;	;	:
cord-289152-w5ynbewh	188	4	Fang	Fang	NNP
cord-289152-w5ynbewh	188	5	et	et	FW
cord-289152-w5ynbewh	188	6	al	al	NNP
cord-289152-w5ynbewh	188	7	.	.	.
cord-289152-w5ynbewh	189	1	,	,	,
cord-289152-w5ynbewh	189	2	2001	2001	CD
cord-289152-w5ynbewh	189	3	;	;	:
cord-289152-w5ynbewh	189	4	Helin	Helin	NNP
cord-289152-w5ynbewh	189	5	et	et	NNP
cord-289152-w5ynbewh	189	6	al	al	NNP
cord-289152-w5ynbewh	189	7	.	.	NNP
cord-289152-w5ynbewh	189	8	,	,	,
cord-289152-w5ynbewh	189	9	2001	2001	CD
cord-289152-w5ynbewh	189	10	)	)	-RRB-
cord-289152-w5ynbewh	189	11	.	.	.
cord-289152-w5ynbewh	190	1	Therefore	therefore	RB
cord-289152-w5ynbewh	190	2	,	,	,
cord-289152-w5ynbewh	190	3	in	in	IN
cord-289152-w5ynbewh	190	4	the	the	DT
cord-289152-w5ynbewh	190	5	present	present	JJ
cord-289152-w5ynbewh	190	6	study	study	NN
cord-289152-w5ynbewh	190	7	,	,	,
cord-289152-w5ynbewh	190	8	both	both	CC
cord-289152-w5ynbewh	190	9	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	190	10	cells	cell	NNS
cord-289152-w5ynbewh	190	11	and	and	CC
cord-289152-w5ynbewh	190	12	PAM	PAM	NNP
cord-289152-w5ynbewh	190	13	cultures	culture	NNS
cord-289152-w5ynbewh	190	14	were	be	VBD
cord-289152-w5ynbewh	190	15	used	use	VBN
cord-289152-w5ynbewh	190	16	to	to	TO
cord-289152-w5ynbewh	190	17	determine	determine	VB
cord-289152-w5ynbewh	190	18	if	if	IN
cord-289152-w5ynbewh	190	19	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	190	20	activates	activate	VBZ
cord-289152-w5ynbewh	190	21	the	the	DT
cord-289152-w5ynbewh	190	22	NF	nf	NN
cord-289152-w5ynbewh	190	23	-	-	HYPH
cord-289152-w5ynbewh	190	24	nB	nB	NNP
cord-289152-w5ynbewh	190	25	pathway	pathway	NN
cord-289152-w5ynbewh	190	26	.	.	.
cord-289152-w5ynbewh	191	1	This	this	DT
cord-289152-w5ynbewh	191	2	study	study	NN
cord-289152-w5ynbewh	191	3	showed	show	VBD
cord-289152-w5ynbewh	191	4	that	that	IN
cord-289152-w5ynbewh	191	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	191	6	infection	infection	NN
cord-289152-w5ynbewh	191	7	resulted	result	VBD
cord-289152-w5ynbewh	191	8	in	in	IN
cord-289152-w5ynbewh	191	9	increased	increase	VBN
cord-289152-w5ynbewh	191	10	nuclear	nuclear	JJ
cord-289152-w5ynbewh	191	11	translocation	translocation	NN
cord-289152-w5ynbewh	191	12	of	of	IN
cord-289152-w5ynbewh	191	13	NF	nf	NN
cord-289152-w5ynbewh	191	14	-	-	HYPH
cord-289152-w5ynbewh	191	15	nB	nb	NN
cord-289152-w5ynbewh	191	16	and	and	CC
cord-289152-w5ynbewh	191	17	increased	increase	VBN
cord-289152-w5ynbewh	191	18	DNA	dna	NN
cord-289152-w5ynbewh	191	19	binding	binding	NN
cord-289152-w5ynbewh	191	20	activity	activity	NN
cord-289152-w5ynbewh	191	21	both	both	CC
cord-289152-w5ynbewh	191	22	in	in	IN
cord-289152-w5ynbewh	191	23	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	191	24	cells	cell	NNS
cord-289152-w5ynbewh	191	25	and	and	CC
cord-289152-w5ynbewh	191	26	PAM	PAM	NNP
cord-289152-w5ynbewh	191	27	cultures	culture	NNS
cord-289152-w5ynbewh	191	28	.	.	.
cord-289152-w5ynbewh	192	1	In	in	IN
cord-289152-w5ynbewh	192	2	addition	addition	NN
cord-289152-w5ynbewh	192	3	,	,	,
cord-289152-w5ynbewh	192	4	NF	NF	NNP
cord-289152-w5ynbewh	192	5	-	-	HYPH
cord-289152-w5ynbewh	192	6	nBdependent	nBdependent	NNP
cord-289152-w5ynbewh	192	7	luciferase	luciferase	JJ
cord-289152-w5ynbewh	192	8	expression	expression	NN
cord-289152-w5ynbewh	192	9	was	be	VBD
cord-289152-w5ynbewh	192	10	significantly	significantly	RB
cord-289152-w5ynbewh	192	11	increased	increase	VBN
cord-289152-w5ynbewh	192	12	in	in	IN
cord-289152-w5ynbewh	192	13	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	192	14	cells	cell	NNS
cord-289152-w5ynbewh	192	15	by	by	IN
cord-289152-w5ynbewh	192	16	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	192	17	infection	infection	NN
cord-289152-w5ynbewh	192	18	.	.	.
cord-289152-w5ynbewh	193	1	Although	although	IN
cord-289152-w5ynbewh	193	2	the	the	DT
cord-289152-w5ynbewh	193	3	NF	nf	NN
cord-289152-w5ynbewh	193	4	-	-	HYPH
cord-289152-w5ynbewh	193	5	nB	nB	NNP
cord-289152-w5ynbewh	193	6	reporter	reporter	NN
cord-289152-w5ynbewh	193	7	assay	assay	NN
cord-289152-w5ynbewh	193	8	was	be	VBD
cord-289152-w5ynbewh	193	9	not	not	RB
cord-289152-w5ynbewh	193	10	successfully	successfully	RB
cord-289152-w5ynbewh	193	11	performed	perform	VBN
cord-289152-w5ynbewh	193	12	in	in	IN
cord-289152-w5ynbewh	193	13	PAM	PAM	NNP
cord-289152-w5ynbewh	193	14	cultures	culture	NNS
cord-289152-w5ynbewh	193	15	(	(	-LRB-
cord-289152-w5ynbewh	193	16	due	due	IN
cord-289152-w5ynbewh	193	17	to	to	IN
cord-289152-w5ynbewh	193	18	extremely	extremely	RB
cord-289152-w5ynbewh	193	19	low	low	JJ
cord-289152-w5ynbewh	193	20	transfection	transfection	NN
cord-289152-w5ynbewh	193	21	efficiencies	efficiency	NNS
cord-289152-w5ynbewh	193	22	of	of	IN
cord-289152-w5ynbewh	193	23	PAM	PAM	NNP
cord-289152-w5ynbewh	193	24	cultures	culture	NNS
cord-289152-w5ynbewh	193	25	)	)	-RRB-
cord-289152-w5ynbewh	193	26	,	,	,
cord-289152-w5ynbewh	193	27	results	result	NNS
cord-289152-w5ynbewh	193	28	presented	present	VBN
cord-289152-w5ynbewh	193	29	here	here	RB
cord-289152-w5ynbewh	193	30	clearly	clearly	RB
cord-289152-w5ynbewh	193	31	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	193	32	that	that	IN
cord-289152-w5ynbewh	193	33	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	193	34	activates	activate	VBZ
cord-289152-w5ynbewh	193	35	the	the	DT
cord-289152-w5ynbewh	193	36	NF	nf	NN
cord-289152-w5ynbewh	193	37	-	-	HYPH
cord-289152-w5ynbewh	193	38	nB	nB	NNP
cord-289152-w5ynbewh	193	39	pathway	pathway	NN
cord-289152-w5ynbewh	193	40	in	in	IN
cord-289152-w5ynbewh	193	41	both	both	CC
cord-289152-w5ynbewh	193	42	its	-PRON-	PRP$
cord-289152-w5ynbewh	193	43	natural	natural	JJ
cord-289152-w5ynbewh	193	44	target	target	NN
cord-289152-w5ynbewh	193	45	cells	cell	NNS
cord-289152-w5ynbewh	193	46	,	,	,
cord-289152-w5ynbewh	193	47	PAM	PAM	NNP
cord-289152-w5ynbewh	193	48	,	,	,
cord-289152-w5ynbewh	193	49	as	as	RB
cord-289152-w5ynbewh	193	50	well	well	RB
cord-289152-w5ynbewh	193	51	as	as	IN
cord-289152-w5ynbewh	193	52	in	in	IN
cord-289152-w5ynbewh	193	53	a	a	DT
cord-289152-w5ynbewh	193	54	continuous	continuous	JJ
cord-289152-w5ynbewh	193	55	cell	cell	NN
cord-289152-w5ynbewh	193	56	line	line	NN
cord-289152-w5ynbewh	193	57	,	,	,
cord-289152-w5ynbewh	193	58	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	193	59	cells	cell	NNS
cord-289152-w5ynbewh	193	60	.	.	.
cord-289152-w5ynbewh	194	1	Viruses	virus	NNS
cord-289152-w5ynbewh	194	2	have	have	VBP
cord-289152-w5ynbewh	194	3	developed	develop	VBN
cord-289152-w5ynbewh	194	4	various	various	JJ
cord-289152-w5ynbewh	194	5	strategies	strategy	NNS
cord-289152-w5ynbewh	194	6	which	which	WDT
cord-289152-w5ynbewh	194	7	lead	lead	VBP
cord-289152-w5ynbewh	194	8	to	to	IN
cord-289152-w5ynbewh	194	9	either	either	CC
cord-289152-w5ynbewh	194	10	activation	activation	NN
cord-289152-w5ynbewh	194	11	or	or	CC
cord-289152-w5ynbewh	194	12	inhibition	inhibition	NN
cord-289152-w5ynbewh	194	13	of	of	IN
cord-289152-w5ynbewh	194	14	NF	nf	NN
cord-289152-w5ynbewh	194	15	-	-	HYPH
cord-289152-w5ynbewh	194	16	nB	nb	NN
cord-289152-w5ynbewh	194	17	-	-	HYPH
cord-289152-w5ynbewh	194	18	dependent	dependent	JJ
cord-289152-w5ynbewh	194	19	gene	gene	NN
cord-289152-w5ynbewh	194	20	transcription	transcription	NN
cord-289152-w5ynbewh	194	21	for	for	IN
cord-289152-w5ynbewh	194	22	their	-PRON-	PRP$
cord-289152-w5ynbewh	194	23	benefits	benefit	NNS
cord-289152-w5ynbewh	195	1	(	(	-LRB-
cord-289152-w5ynbewh	195	2	Santoro	Santoro	NNP
cord-289152-w5ynbewh	195	3	et	et	NNP
cord-289152-w5ynbewh	195	4	al	al	NNP
cord-289152-w5ynbewh	195	5	.	.	NNP
cord-289152-w5ynbewh	195	6	,	,	,
cord-289152-w5ynbewh	195	7	2003	2003	CD
cord-289152-w5ynbewh	195	8	)	)	-RRB-
cord-289152-w5ynbewh	195	9	.	.	.
cord-289152-w5ynbewh	196	1	The	the	DT
cord-289152-w5ynbewh	196	2	NF	nf	NN
cord-289152-w5ynbewh	196	3	-	-	HYPH
cord-289152-w5ynbewh	196	4	nB	nB	NNP
cord-289152-w5ynbewh	196	5	pathway	pathway	NN
cord-289152-w5ynbewh	196	6	can	can	MD
cord-289152-w5ynbewh	196	7	be	be	VB
cord-289152-w5ynbewh	196	8	activated	activate	VBN
cord-289152-w5ynbewh	196	9	as	as	IN
cord-289152-w5ynbewh	196	10	a	a	DT
cord-289152-w5ynbewh	196	11	protective	protective	JJ
cord-289152-w5ynbewh	196	12	response	response	NN
cord-289152-w5ynbewh	196	13	of	of	IN
cord-289152-w5ynbewh	196	14	the	the	DT
cord-289152-w5ynbewh	196	15	host	host	NN
cord-289152-w5ynbewh	196	16	to	to	IN
cord-289152-w5ynbewh	196	17	viruses	virus	NNS
cord-289152-w5ynbewh	196	18	.	.	.
cord-289152-w5ynbewh	197	1	Therefore	therefore	RB
cord-289152-w5ynbewh	197	2	,	,	,
cord-289152-w5ynbewh	197	3	some	some	DT
cord-289152-w5ynbewh	197	4	viruses	virus	NNS
cord-289152-w5ynbewh	197	5	,	,	,
cord-289152-w5ynbewh	197	6	such	such	JJ
cord-289152-w5ynbewh	197	7	as	as	IN
cord-289152-w5ynbewh	197	8	vaccinia	vaccinia	NN
cord-289152-w5ynbewh	197	9	virus	virus	NN
cord-289152-w5ynbewh	197	10	,	,	,
cord-289152-w5ynbewh	197	11	African	african	JJ
cord-289152-w5ynbewh	197	12	swine	swine	NN
cord-289152-w5ynbewh	197	13	fever	fever	NN
cord-289152-w5ynbewh	197	14	virus	virus	NN
cord-289152-w5ynbewh	197	15	,	,	,
cord-289152-w5ynbewh	197	16	influenza	influenza	NN
cord-289152-w5ynbewh	197	17	A	a	DT
cord-289152-w5ynbewh	197	18	virus	virus	NN
cord-289152-w5ynbewh	197	19	,	,	,
cord-289152-w5ynbewh	197	20	and	and	CC
cord-289152-w5ynbewh	197	21	mengovirus	mengovirus	NNP
cord-289152-w5ynbewh	197	22	,	,	,
cord-289152-w5ynbewh	197	23	have	have	VBP
cord-289152-w5ynbewh	197	24	evolved	evolve	VBN
cord-289152-w5ynbewh	197	25	strategies	strategy	NNS
cord-289152-w5ynbewh	197	26	to	to	TO
cord-289152-w5ynbewh	197	27	block	block	VB
cord-289152-w5ynbewh	197	28	NF	NF	NNP
cord-289152-w5ynbewh	197	29	-	-	HYPH
cord-289152-w5ynbewh	197	30	nB	nB	NNP
cord-289152-w5ynbewh	197	31	activation	activation	NN
cord-289152-w5ynbewh	197	32	in	in	IN
cord-289152-w5ynbewh	197	33	order	order	NN
cord-289152-w5ynbewh	197	34	to	to	TO
cord-289152-w5ynbewh	197	35	evade	evade	VB
cord-289152-w5ynbewh	197	36	the	the	DT
cord-289152-w5ynbewh	197	37	innate	innate	JJ
cord-289152-w5ynbewh	197	38	immune	immune	JJ
cord-289152-w5ynbewh	197	39	response	response	NN
cord-289152-w5ynbewh	197	40	(	(	-LRB-
cord-289152-w5ynbewh	197	41	Powell	Powell	NNP
cord-289152-w5ynbewh	197	42	et	et	NNP
cord-289152-w5ynbewh	197	43	al	al	NNP
cord-289152-w5ynbewh	197	44	.	.	NNP
cord-289152-w5ynbewh	197	45	,	,	,
cord-289152-w5ynbewh	197	46	1996	1996	CD
cord-289152-w5ynbewh	197	47	;	;	:
cord-289152-w5ynbewh	197	48	Shisler	Shisler	NNP
cord-289152-w5ynbewh	197	49	and	and	CC
cord-289152-w5ynbewh	197	50	Jin	Jin	NNP
cord-289152-w5ynbewh	197	51	,	,	,
cord-289152-w5ynbewh	197	52	2004	2004	CD
cord-289152-w5ynbewh	197	53	;	;	:
cord-289152-w5ynbewh	197	54	Wang	Wang	NNP
cord-289152-w5ynbewh	197	55	et	et	NNP
cord-289152-w5ynbewh	197	56	al	al	NNP
cord-289152-w5ynbewh	197	57	.	.	NNP
cord-289152-w5ynbewh	197	58	,	,	,
cord-289152-w5ynbewh	197	59	2000	2000	CD
cord-289152-w5ynbewh	197	60	;	;	:
cord-289152-w5ynbewh	198	1	Zoll	Zoll	NNP
cord-289152-w5ynbewh	198	2	et	et	FW
cord-289152-w5ynbewh	198	3	al	al	NNP
cord-289152-w5ynbewh	198	4	.	.	NNP
cord-289152-w5ynbewh	198	5	,	,	,
cord-289152-w5ynbewh	198	6	2002	2002	CD
cord-289152-w5ynbewh	198	7	)	)	-RRB-
cord-289152-w5ynbewh	198	8	.	.	.
cord-289152-w5ynbewh	199	1	The	the	DT
cord-289152-w5ynbewh	199	2	NF	nf	NN
cord-289152-w5ynbewh	199	3	-	-	HYPH
cord-289152-w5ynbewh	199	4	nB	nB	NNP
cord-289152-w5ynbewh	199	5	pathway	pathway	NN
cord-289152-w5ynbewh	199	6	can	can	MD
cord-289152-w5ynbewh	199	7	also	also	RB
cord-289152-w5ynbewh	199	8	be	be	VB
cord-289152-w5ynbewh	199	9	activated	activate	VBN
cord-289152-w5ynbewh	199	10	directly	directly	RB
cord-289152-w5ynbewh	199	11	by	by	IN
cord-289152-w5ynbewh	199	12	viruses	virus	NNS
cord-289152-w5ynbewh	199	13	.	.	.
cord-289152-w5ynbewh	200	1	Viruses	virus	NNS
cord-289152-w5ynbewh	200	2	including	include	VBG
cord-289152-w5ynbewh	200	3	HIV	HIV	NNP
cord-289152-w5ynbewh	200	4	,	,	,
cord-289152-w5ynbewh	200	5	herpesviruses	herpesviruses	NNP
cord-289152-w5ynbewh	200	6	,	,	,
cord-289152-w5ynbewh	200	7	hepatitis	hepatitis	NN
cord-289152-w5ynbewh	200	8	C	C	NNP
cord-289152-w5ynbewh	200	9	virus	virus	NN
cord-289152-w5ynbewh	200	10	,	,	,
cord-289152-w5ynbewh	200	11	encephalomyocarditis	encephalomyocarditis	NNP
cord-289152-w5ynbewh	200	12	virus	virus	NN
cord-289152-w5ynbewh	200	13	,	,	,
cord-289152-w5ynbewh	200	14	reovirus	reovirus	NNP
cord-289152-w5ynbewh	200	15	,	,	,
cord-289152-w5ynbewh	200	16	dengue	dengue	NN
cord-289152-w5ynbewh	200	17	virus	virus	NN
cord-289152-w5ynbewh	200	18	,	,	,
cord-289152-w5ynbewh	200	19	West	West	NNP
cord-289152-w5ynbewh	200	20	Nile	Nile	NNP
cord-289152-w5ynbewh	200	21	virus	virus	NN
cord-289152-w5ynbewh	200	22	,	,	,
cord-289152-w5ynbewh	200	23	and	and	CC
cord-289152-w5ynbewh	200	24	herpes	herpes	NNP
cord-289152-w5ynbewh	200	25	simplex	simplex	NNP
cord-289152-w5ynbewh	200	26	virus	virus	NN
cord-289152-w5ynbewh	200	27	have	have	VBP
cord-289152-w5ynbewh	200	28	evolved	evolve	VBN
cord-289152-w5ynbewh	200	29	strategies	strategy	NNS
cord-289152-w5ynbewh	200	30	to	to	TO
cord-289152-w5ynbewh	200	31	activate	activate	VB
cord-289152-w5ynbewh	200	32	NF	NF	NNP
cord-289152-w5ynbewh	200	33	-	-	HYPH
cord-289152-w5ynbewh	200	34	nB	nB	NNP
cord-289152-w5ynbewh	200	35	to	to	TO
cord-289152-w5ynbewh	200	36	exploit	exploit	VB
cord-289152-w5ynbewh	200	37	NF	nf	NN
cord-289152-w5ynbewh	200	38	-	-	HYPH
cord-289152-w5ynbewh	200	39	nB	nB	NNP
cord-289152-w5ynbewh	200	40	for	for	IN
cord-289152-w5ynbewh	200	41	optimized	optimize	VBN
cord-289152-w5ynbewh	200	42	replication	replication	NN
cord-289152-w5ynbewh	200	43	,	,	,
cord-289152-w5ynbewh	200	44	or	or	CC
cord-289152-w5ynbewh	200	45	to	to	TO
cord-289152-w5ynbewh	200	46	control	control	VB
cord-289152-w5ynbewh	200	47	host	host	NN
cord-289152-w5ynbewh	200	48	cell	cell	NN
cord-289152-w5ynbewh	200	49	proliferation	proliferation	NN
cord-289152-w5ynbewh	200	50	and	and	CC
cord-289152-w5ynbewh	200	51	survival	survival	NN
cord-289152-w5ynbewh	200	52	to	to	TO
cord-289152-w5ynbewh	200	53	maximize	maximize	VB
cord-289152-w5ynbewh	200	54	viral	viral	JJ
cord-289152-w5ynbewh	200	55	progeny	progeny	NN
cord-289152-w5ynbewh	200	56	production	production	NN
cord-289152-w5ynbewh	200	57	(	(	-LRB-
cord-289152-w5ynbewh	200	58	Connolly	Connolly	NNP
cord-289152-w5ynbewh	200	59	et	et	NNP
cord-289152-w5ynbewh	200	60	al	al	NNP
cord-289152-w5ynbewh	200	61	.	.	NNP
cord-289152-w5ynbewh	200	62	,	,	,
cord-289152-w5ynbewh	200	63	2000	2000	CD
cord-289152-w5ynbewh	200	64	;	;	:
cord-289152-w5ynbewh	200	65	Goodkin	Goodkin	NNP
cord-289152-w5ynbewh	200	66	et	et	FW
cord-289152-w5ynbewh	200	67	al	al	NNP
cord-289152-w5ynbewh	200	68	.	.	NNP
cord-289152-w5ynbewh	200	69	,	,	,
cord-289152-w5ynbewh	200	70	2003	2003	CD
cord-289152-w5ynbewh	200	71	;	;	:
cord-289152-w5ynbewh	201	1	Jan	Jan	NNP
cord-289152-w5ynbewh	201	2	et	et	NNP
cord-289152-w5ynbewh	201	3	al	al	NNP
cord-289152-w5ynbewh	201	4	.	.	NNP
cord-289152-w5ynbewh	201	5	,	,	,
cord-289152-w5ynbewh	201	6	2000	2000	CD
cord-289152-w5ynbewh	202	1	;	;	:
cord-289152-w5ynbewh	202	2	Santoro	Santoro	NNP
cord-289152-w5ynbewh	202	3	et	et	NNP
cord-289152-w5ynbewh	202	4	al	al	NNP
cord-289152-w5ynbewh	202	5	.	.	NNP
cord-289152-w5ynbewh	202	6	,	,	,
cord-289152-w5ynbewh	202	7	2003	2003	CD
cord-289152-w5ynbewh	202	8	;	;	:
cord-289152-w5ynbewh	202	9	Schwarz	Schwarz	NNP
cord-289152-w5ynbewh	202	10	et	et	NNP
cord-289152-w5ynbewh	202	11	al	al	NNP
cord-289152-w5ynbewh	202	12	.	.	NNP
cord-289152-w5ynbewh	202	13	,	,	,
cord-289152-w5ynbewh	202	14	1998	1998	CD
cord-289152-w5ynbewh	202	15	;	;	:
cord-289152-w5ynbewh	202	16	Waris	Waris	NNP
cord-289152-w5ynbewh	202	17	et	et	NNP
cord-289152-w5ynbewh	202	18	al	al	NNP
cord-289152-w5ynbewh	202	19	.	.	NNP
cord-289152-w5ynbewh	202	20	,	,	,
cord-289152-w5ynbewh	202	21	2003	2003	CD
cord-289152-w5ynbewh	202	22	)	)	-RRB-
cord-289152-w5ynbewh	202	23	.	.	.
cord-289152-w5ynbewh	203	1	Despite	despite	IN
cord-289152-w5ynbewh	203	2	the	the	DT
cord-289152-w5ynbewh	203	3	importance	importance	NN
cord-289152-w5ynbewh	203	4	of	of	IN
cord-289152-w5ynbewh	203	5	the	the	DT
cord-289152-w5ynbewh	203	6	NF	nf	NN
cord-289152-w5ynbewh	203	7	-	-	HYPH
cord-289152-w5ynbewh	203	8	nB	nB	NNP
cord-289152-w5ynbewh	203	9	pathway	pathway	NN
cord-289152-w5ynbewh	203	10	in	in	IN
cord-289152-w5ynbewh	203	11	immune	immune	JJ
cord-289152-w5ynbewh	203	12	response	response	NN
cord-289152-w5ynbewh	203	13	,	,	,
cord-289152-w5ynbewh	203	14	it	-PRON-	PRP
cord-289152-w5ynbewh	203	15	has	have	VBZ
cord-289152-w5ynbewh	203	16	not	not	RB
cord-289152-w5ynbewh	203	17	been	be	VBN
cord-289152-w5ynbewh	203	18	determined	determine	VBN
cord-289152-w5ynbewh	203	19	if	if	IN
cord-289152-w5ynbewh	203	20	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	203	21	or	or	CC
cord-289152-w5ynbewh	203	22	other	other	JJ
cord-289152-w5ynbewh	203	23	arteriviruses	arteriviruse	NNS
cord-289152-w5ynbewh	203	24	modulate	modulate	VBP
cord-289152-w5ynbewh	203	25	this	this	DT
cord-289152-w5ynbewh	203	26	pathway	pathway	NN
cord-289152-w5ynbewh	203	27	.	.	.
cord-289152-w5ynbewh	204	1	Previous	previous	JJ
cord-289152-w5ynbewh	204	2	studies	study	NNS
cord-289152-w5ynbewh	204	3	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	204	4	that	that	IN
cord-289152-w5ynbewh	204	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	204	6	induced	induce	VBD
cord-289152-w5ynbewh	204	7	weak	weak	JJ
cord-289152-w5ynbewh	204	8	type	type	NN
cord-289152-w5ynbewh	205	1	I	-PRON-	PRP
cord-289152-w5ynbewh	205	2	IFN	IFN	NNP
cord-289152-w5ynbewh	205	3	responses	response	NNS
cord-289152-w5ynbewh	205	4	(	(	-LRB-
cord-289152-w5ynbewh	206	1	Albina	Albina	NNP
cord-289152-w5ynbewh	206	2	et	et	NNP
cord-289152-w5ynbewh	206	3	al	al	NNP
cord-289152-w5ynbewh	206	4	.	.	.
cord-289152-w5ynbewh	207	1	,	,	,
cord-289152-w5ynbewh	207	2	1998a	1998a	CD
cord-289152-w5ynbewh	207	3	;	;	:
cord-289152-w5ynbewh	207	4	Lee	Lee	NNP
cord-289152-w5ynbewh	207	5	et	et	NNP
cord-289152-w5ynbewh	207	6	al	al	NNP
cord-289152-w5ynbewh	207	7	.	.	NNP
cord-289152-w5ynbewh	207	8	,	,	,
cord-289152-w5ynbewh	207	9	2004	2004	CD
cord-289152-w5ynbewh	208	1	;	;	:
cord-289152-w5ynbewh	208	2	Miller	Miller	NNP
cord-289152-w5ynbewh	208	3	et	et	NNP
cord-289152-w5ynbewh	208	4	al	al	NNP
cord-289152-w5ynbewh	208	5	.	.	NNP
cord-289152-w5ynbewh	208	6	,	,	,
cord-289152-w5ynbewh	208	7	2004	2004	CD
cord-289152-w5ynbewh	208	8	;	;	:
cord-289152-w5ynbewh	209	1	Van	Van	NNP
cord-289152-w5ynbewh	209	2	Reeth	Reeth	NNP
cord-289152-w5ynbewh	209	3	et	et	NNP
cord-289152-w5ynbewh	209	4	al	al	NNP
cord-289152-w5ynbewh	209	5	.	.	NNP
cord-289152-w5ynbewh	209	6	,	,	,
cord-289152-w5ynbewh	209	7	1999	1999	CD
cord-289152-w5ynbewh	209	8	)	)	-RRB-
cord-289152-w5ynbewh	209	9	.	.	.
cord-289152-w5ynbewh	210	1	Therefore	therefore	RB
cord-289152-w5ynbewh	210	2	,	,	,
cord-289152-w5ynbewh	210	3	it	-PRON-	PRP
cord-289152-w5ynbewh	210	4	has	have	VBZ
cord-289152-w5ynbewh	210	5	been	be	VBN
cord-289152-w5ynbewh	210	6	postulated	postulate	VBN
cord-289152-w5ynbewh	210	7	that	that	IN
cord-289152-w5ynbewh	210	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	210	9	inhibited	inhibit	VBD
cord-289152-w5ynbewh	210	10	the	the	DT
cord-289152-w5ynbewh	210	11	NF	nf	NN
cord-289152-w5ynbewh	210	12	-	-	HYPH
cord-289152-w5ynbewh	210	13	nB	nB	NNP
cord-289152-w5ynbewh	210	14	pathway	pathway	NN
cord-289152-w5ynbewh	210	15	to	to	TO
cord-289152-w5ynbewh	210	16	evade	evade	VB
cord-289152-w5ynbewh	210	17	antiviral	antiviral	JJ
cord-289152-w5ynbewh	210	18	responses	response	NNS
cord-289152-w5ynbewh	210	19	of	of	IN
cord-289152-w5ynbewh	210	20	host	host	NN
cord-289152-w5ynbewh	210	21	cells	cell	NNS
cord-289152-w5ynbewh	210	22	.	.	.
cord-289152-w5ynbewh	211	1	However	however	RB
cord-289152-w5ynbewh	211	2	,	,	,
cord-289152-w5ynbewh	211	3	the	the	DT
cord-289152-w5ynbewh	211	4	present	present	JJ
cord-289152-w5ynbewh	211	5	study	study	NN
cord-289152-w5ynbewh	211	6	provides	provide	VBZ
cord-289152-w5ynbewh	211	7	evidence	evidence	NN
cord-289152-w5ynbewh	211	8	that	that	IN
cord-289152-w5ynbewh	211	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	211	10	actually	actually	RB
cord-289152-w5ynbewh	211	11	activates	activate	VBZ
cord-289152-w5ynbewh	211	12	the	the	DT
cord-289152-w5ynbewh	211	13	NF	nf	NN
cord-289152-w5ynbewh	211	14	-	-	HYPH
cord-289152-w5ynbewh	211	15	nB	nB	NNP
cord-289152-w5ynbewh	211	16	pathway	pathway	NN
cord-289152-w5ynbewh	211	17	in	in	IN
cord-289152-w5ynbewh	211	18	PAMs	pam	NNS
cord-289152-w5ynbewh	211	19	,	,	,
cord-289152-w5ynbewh	211	20	which	which	WDT
cord-289152-w5ynbewh	211	21	are	be	VBP
cord-289152-w5ynbewh	211	22	primary	primary	JJ
cord-289152-w5ynbewh	211	23	target	target	NN
cord-289152-w5ynbewh	211	24	cells	cell	NNS
cord-289152-w5ynbewh	211	25	in	in	IN
cord-289152-w5ynbewh	211	26	vivo	vivo	NN
cord-289152-w5ynbewh	211	27	.	.	.
cord-289152-w5ynbewh	212	1	The	the	DT
cord-289152-w5ynbewh	212	2	synthesis	synthesis	NN
cord-289152-w5ynbewh	212	3	of	of	IN
cord-289152-w5ynbewh	212	4	type	type	NN
cord-289152-w5ynbewh	212	5	I	-PRON-	PRP
cord-289152-w5ynbewh	212	6	IFN	IFN	NNP
cord-289152-w5ynbewh	212	7	is	be	VBZ
cord-289152-w5ynbewh	212	8	regulated	regulate	VBN
cord-289152-w5ynbewh	212	9	trascriptionally	trascriptionally	RB
cord-289152-w5ynbewh	212	10	and	and	CC
cord-289152-w5ynbewh	212	11	post	post	VB
cord-289152-w5ynbewh	212	12	-	-	NN
cord-289152-w5ynbewh	212	13	transcriptionally	transcriptionally	RB
cord-289152-w5ynbewh	212	14	,	,	,
cord-289152-w5ynbewh	212	15	and	and	CC
cord-289152-w5ynbewh	212	16	various	various	JJ
cord-289152-w5ynbewh	212	17	transcription	transcription	NN
cord-289152-w5ynbewh	212	18	factors	factor	NNS
cord-289152-w5ynbewh	212	19	such	such	JJ
cord-289152-w5ynbewh	212	20	as	as	IN
cord-289152-w5ynbewh	212	21	the	the	DT
cord-289152-w5ynbewh	212	22	interferon	interferon	NN
cord-289152-w5ynbewh	212	23	regulatory	regulatory	JJ
cord-289152-w5ynbewh	212	24	factor	factor	NN
cord-289152-w5ynbewh	213	1	(	(	-LRB-
cord-289152-w5ynbewh	213	2	IRF	IRF	NNP
cord-289152-w5ynbewh	213	3	)	)	-RRB-
cord-289152-w5ynbewh	213	4	family	family	NN
cord-289152-w5ynbewh	213	5	as	as	RB
cord-289152-w5ynbewh	213	6	well	well	RB
cord-289152-w5ynbewh	213	7	as	as	IN
cord-289152-w5ynbewh	213	8	NF	nf	NN
cord-289152-w5ynbewh	213	9	-	-	HYPH
cord-289152-w5ynbewh	213	10	nB	nB	NNP
cord-289152-w5ynbewh	213	11	may	may	MD
cord-289152-w5ynbewh	213	12	be	be	VB
cord-289152-w5ynbewh	213	13	involved	involve	VBN
cord-289152-w5ynbewh	214	1	(	(	-LRB-
cord-289152-w5ynbewh	214	2	Hiscott	Hiscott	NNP
cord-289152-w5ynbewh	214	3	et	et	NNP
cord-289152-w5ynbewh	214	4	al	al	NNP
cord-289152-w5ynbewh	214	5	.	.	NNP
cord-289152-w5ynbewh	214	6	,	,	,
cord-289152-w5ynbewh	214	7	2003	2003	CD
cord-289152-w5ynbewh	215	1	;	;	:
cord-289152-w5ynbewh	215	2	Taniguchi	Taniguchi	NNP
cord-289152-w5ynbewh	215	3	and	and	CC
cord-289152-w5ynbewh	215	4	Takaoka	Takaoka	NNP
cord-289152-w5ynbewh	215	5	,	,	,
cord-289152-w5ynbewh	215	6	2002	2002	CD
cord-289152-w5ynbewh	215	7	;	;	:
cord-289152-w5ynbewh	215	8	Wathelet	Wathelet	NNP
cord-289152-w5ynbewh	215	9	et	et	NNP
cord-289152-w5ynbewh	215	10	al	al	NNP
cord-289152-w5ynbewh	215	11	.	.	NNP
cord-289152-w5ynbewh	215	12	,	,	,
cord-289152-w5ynbewh	215	13	1998	1998	CD
cord-289152-w5ynbewh	215	14	)	)	-RRB-
cord-289152-w5ynbewh	215	15	.	.	.
cord-289152-w5ynbewh	216	1	Therefore	therefore	RB
cord-289152-w5ynbewh	216	2	,	,	,
cord-289152-w5ynbewh	216	3	it	-PRON-	PRP
cord-289152-w5ynbewh	216	4	is	be	VBZ
cord-289152-w5ynbewh	216	5	possible	possible	JJ
cord-289152-w5ynbewh	216	6	that	that	IN
cord-289152-w5ynbewh	216	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	216	8	blocks	block	VBZ
cord-289152-w5ynbewh	216	9	IFN	IFN	NNP
cord-289152-w5ynbewh	216	10	gene	gene	NN
cord-289152-w5ynbewh	216	11	expression	expression	NN
cord-289152-w5ynbewh	216	12	at	at	IN
cord-289152-w5ynbewh	217	1	transcriptional	transcriptional	NNP
cord-289152-w5ynbewh	217	2	and/or	and/or	CC
cord-289152-w5ynbewh	217	3	post	post	JJ
cord-289152-w5ynbewh	217	4	-	-	JJ
cord-289152-w5ynbewh	217	5	transcription	transcription	JJ
cord-289152-w5ynbewh	217	6	levels	level	NNS
cord-289152-w5ynbewh	217	7	but	but	CC
cord-289152-w5ynbewh	217	8	does	do	VBZ
cord-289152-w5ynbewh	217	9	not	not	RB
cord-289152-w5ynbewh	217	10	inhibit	inhibit	VB
cord-289152-w5ynbewh	217	11	the	the	DT
cord-289152-w5ynbewh	217	12	NF	nf	NN
cord-289152-w5ynbewh	217	13	-	-	HYPH
cord-289152-w5ynbewh	217	14	nB	nB	NNP
cord-289152-w5ynbewh	217	15	pathway	pathway	NN
cord-289152-w5ynbewh	217	16	.	.	.
cord-289152-w5ynbewh	218	1	Fig	Fig	NNP
cord-289152-w5ynbewh	218	2	.	.	.
cord-289152-w5ynbewh	219	1	8	8	CD
cord-289152-w5ynbewh	219	2	.	.	.
cord-289152-w5ynbewh	220	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	220	2	increases	increase	VBZ
cord-289152-w5ynbewh	220	3	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	220	4	and	and	CC
cord-289152-w5ynbewh	220	5	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	220	6	gene	gene	NN
cord-289152-w5ynbewh	220	7	expression	expression	NN
cord-289152-w5ynbewh	220	8	through	through	IN
cord-289152-w5ynbewh	220	9	an	an	DT
cord-289152-w5ynbewh	220	10	NF	nf	NN
cord-289152-w5ynbewh	220	11	-	-	HYPH
cord-289152-w5ynbewh	220	12	nB	nb	NN
cord-289152-w5ynbewh	220	13	-	-	HYPH
cord-289152-w5ynbewh	220	14	dependent	dependent	JJ
cord-289152-w5ynbewh	220	15	pathway	pathway	NN
cord-289152-w5ynbewh	220	16	.	.	.
cord-289152-w5ynbewh	221	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	221	2	cells	cell	NNS
cord-289152-w5ynbewh	221	3	were	be	VBD
cord-289152-w5ynbewh	221	4	infected	infect	VBN
cord-289152-w5ynbewh	221	5	with	with	IN
cord-289152-w5ynbewh	221	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	221	7	for	for	IN
cord-289152-w5ynbewh	221	8	48	48	CD
cord-289152-w5ynbewh	221	9	h	h	NN
cord-289152-w5ynbewh	221	10	at	at	IN
cord-289152-w5ynbewh	221	11	MOI	MOI	NNP
cord-289152-w5ynbewh	221	12	=	=	SYM
cord-289152-w5ynbewh	221	13	0.1	0.1	CD
cord-289152-w5ynbewh	221	14	,	,	,
cord-289152-w5ynbewh	221	15	and	and	CC
cord-289152-w5ynbewh	221	16	total	total	JJ
cord-289152-w5ynbewh	221	17	RNA	RNA	NNP
cord-289152-w5ynbewh	221	18	was	be	VBD
cord-289152-w5ynbewh	221	19	extracted	extract	VBN
cord-289152-w5ynbewh	221	20	and	and	CC
cord-289152-w5ynbewh	221	21	treated	treat	VBN
cord-289152-w5ynbewh	221	22	with	with	IN
cord-289152-w5ynbewh	221	23	DNase	DNase	NNP
cord-289152-w5ynbewh	221	24	I.	I.	NNP
cord-289152-w5ynbewh	221	25	Quantitative	quantitative	JJ
cord-289152-w5ynbewh	221	26	real	real	JJ
cord-289152-w5ynbewh	221	27	-	-	HYPH
cord-289152-w5ynbewh	221	28	time	time	NN
cord-289152-w5ynbewh	221	29	RT	RT	NNP
cord-289152-w5ynbewh	221	30	-	-	HYPH
cord-289152-w5ynbewh	221	31	PCR	PCR	NNP
cord-289152-w5ynbewh	221	32	was	be	VBD
cord-289152-w5ynbewh	221	33	performed	perform	VBN
cord-289152-w5ynbewh	221	34	for	for	IN
cord-289152-w5ynbewh	221	35	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	221	36	or	or	CC
cord-289152-w5ynbewh	221	37	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	221	38	specific	specific	JJ
cord-289152-w5ynbewh	221	39	primers	primer	NNS
cord-289152-w5ynbewh	221	40	.	.	.
cord-289152-w5ynbewh	222	1	Results	result	NNS
cord-289152-w5ynbewh	222	2	are	be	VBP
cord-289152-w5ynbewh	222	3	expressed	express	VBN
cord-289152-w5ynbewh	222	4	as	as	IN
cord-289152-w5ynbewh	222	5	relative	relative	JJ
cord-289152-w5ynbewh	222	6	fold	fold	JJ
cord-289152-w5ynbewh	222	7	changes	change	NNS
cord-289152-w5ynbewh	222	8	of	of	IN
cord-289152-w5ynbewh	222	9	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	222	10	or	or	CC
cord-289152-w5ynbewh	222	11	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	222	12	mRNA	mrna	NN
cord-289152-w5ynbewh	222	13	using	use	VBG
cord-289152-w5ynbewh	222	14	cyclophilin	cyclophilin	NNP
cord-289152-w5ynbewh	222	15	as	as	IN
cord-289152-w5ynbewh	222	16	an	an	DT
cord-289152-w5ynbewh	222	17	internal	internal	JJ
cord-289152-w5ynbewh	222	18	control	control	NN
cord-289152-w5ynbewh	222	19	.	.	.
cord-289152-w5ynbewh	223	1	Values	value	NNS
cord-289152-w5ynbewh	223	2	are	be	VBP
cord-289152-w5ynbewh	223	3	shown	show	VBN
cord-289152-w5ynbewh	223	4	as	as	IN
cord-289152-w5ynbewh	223	5	the	the	DT
cord-289152-w5ynbewh	223	6	means	mean	NNS
cord-289152-w5ynbewh	223	7	T	T	NNP
cord-289152-w5ynbewh	223	8	SD	sd	NN
cord-289152-w5ynbewh	223	9	from	from	IN
cord-289152-w5ynbewh	223	10	triplicate	triplicate	JJ
cord-289152-w5ynbewh	223	11	wells	well	NNS
cord-289152-w5ynbewh	223	12	and	and	CC
cord-289152-w5ynbewh	223	13	represent	represent	VB
cord-289152-w5ynbewh	223	14	two	two	CD
cord-289152-w5ynbewh	223	15	independent	independent	JJ
cord-289152-w5ynbewh	223	16	experiments	experiment	NNS
cord-289152-w5ynbewh	223	17	.	.	.
cord-289152-w5ynbewh	224	1	*	*	NFP
cord-289152-w5ynbewh	224	2	P	p	NN
cord-289152-w5ynbewh	224	3	<	<	XX
cord-289152-w5ynbewh	224	4	0.001	0.001	CD
cord-289152-w5ynbewh	224	5	compared	compare	VBN
cord-289152-w5ynbewh	224	6	to	to	IN
cord-289152-w5ynbewh	224	7	Ad	ad	NN
cord-289152-w5ynbewh	224	8	-	-	HYPH
cord-289152-w5ynbewh	224	9	eGFP	egfp	NN
cord-289152-w5ynbewh	224	10	/	/	SYM
cord-289152-w5ynbewh	224	11	PRRSVinfected	prrsvinfecte	VBN
cord-289152-w5ynbewh	224	12	cells	cell	NNS
cord-289152-w5ynbewh	224	13	.	.	.
cord-289152-w5ynbewh	225	1	A	a	DT
cord-289152-w5ynbewh	225	2	number	number	NN
cord-289152-w5ynbewh	225	3	of	of	IN
cord-289152-w5ynbewh	225	4	studies	study	NNS
cord-289152-w5ynbewh	225	5	have	have	VBP
cord-289152-w5ynbewh	225	6	suggested	suggest	VBN
cord-289152-w5ynbewh	225	7	that	that	IN
cord-289152-w5ynbewh	225	8	oxidative	oxidative	JJ
cord-289152-w5ynbewh	225	9	stress	stress	NN
cord-289152-w5ynbewh	225	10	induced	induce	VBN
cord-289152-w5ynbewh	225	11	by	by	IN
cord-289152-w5ynbewh	225	12	increased	increase	VBN
cord-289152-w5ynbewh	225	13	generation	generation	NN
cord-289152-w5ynbewh	225	14	of	of	IN
cord-289152-w5ynbewh	225	15	ROS	ROS	NNP
cord-289152-w5ynbewh	225	16	is	be	VBZ
cord-289152-w5ynbewh	225	17	involved	involve	VBN
cord-289152-w5ynbewh	225	18	in	in	IN
cord-289152-w5ynbewh	225	19	the	the	DT
cord-289152-w5ynbewh	225	20	activation	activation	NN
cord-289152-w5ynbewh	225	21	of	of	IN
cord-289152-w5ynbewh	225	22	NF	nf	NN
cord-289152-w5ynbewh	225	23	-	-	HYPH
cord-289152-w5ynbewh	225	24	nB	nB	NNP
cord-289152-w5ynbewh	226	1	(	(	-LRB-
cord-289152-w5ynbewh	226	2	Ghosh	Ghosh	NNP
cord-289152-w5ynbewh	226	3	and	and	CC
cord-289152-w5ynbewh	226	4	Karin	Karin	NNP
cord-289152-w5ynbewh	226	5	,	,	,
cord-289152-w5ynbewh	226	6	2002	2002	CD
cord-289152-w5ynbewh	226	7	;	;	:
cord-289152-w5ynbewh	226	8	Janssen	Janssen	NNP
cord-289152-w5ynbewh	226	9	-	-	HYPH
cord-289152-w5ynbewh	226	10	Heininger	Heininger	NNP
cord-289152-w5ynbewh	226	11	et	et	NNP
cord-289152-w5ynbewh	226	12	al	al	NNP
cord-289152-w5ynbewh	226	13	.	.	NNP
cord-289152-w5ynbewh	226	14	,	,	,
cord-289152-w5ynbewh	226	15	2000	2000	CD
cord-289152-w5ynbewh	226	16	)	)	-RRB-
cord-289152-w5ynbewh	226	17	.	.	.
cord-289152-w5ynbewh	227	1	Virus	virus	NN
cord-289152-w5ynbewh	227	2	infections	infection	NNS
cord-289152-w5ynbewh	227	3	such	such	JJ
cord-289152-w5ynbewh	227	4	as	as	IN
cord-289152-w5ynbewh	227	5	human	human	JJ
cord-289152-w5ynbewh	227	6	immunodeficiency	immunodeficiency	NN
cord-289152-w5ynbewh	227	7	virus	virus	NN
cord-289152-w5ynbewh	227	8	(	(	-LRB-
cord-289152-w5ynbewh	227	9	HIV	HIV	NNP
cord-289152-w5ynbewh	227	10	)	)	-RRB-
cord-289152-w5ynbewh	227	11	(	(	-LRB-
cord-289152-w5ynbewh	227	12	Israel	Israel	NNP
cord-289152-w5ynbewh	227	13	and	and	CC
cord-289152-w5ynbewh	227	14	Gougerot	Gougerot	NNP
cord-289152-w5ynbewh	227	15	-	-	HYPH
cord-289152-w5ynbewh	227	16	Pocidalo	Pocidalo	NNP
cord-289152-w5ynbewh	227	17	,	,	,
cord-289152-w5ynbewh	227	18	1997	1997	CD
cord-289152-w5ynbewh	227	19	)	)	-RRB-
cord-289152-w5ynbewh	227	20	,	,	,
cord-289152-w5ynbewh	227	21	cytomegalovirus	cytomegalovirus	NNP
cord-289152-w5ynbewh	227	22	(	(	-LRB-
cord-289152-w5ynbewh	227	23	CMV	CMV	NNP
cord-289152-w5ynbewh	227	24	)	)	-RRB-
cord-289152-w5ynbewh	227	25	(	(	-LRB-
cord-289152-w5ynbewh	227	26	Speir	Speir	NNP
cord-289152-w5ynbewh	227	27	,	,	,
cord-289152-w5ynbewh	227	28	2000	2000	CD
cord-289152-w5ynbewh	227	29	)	)	-RRB-
cord-289152-w5ynbewh	227	30	,	,	,
cord-289152-w5ynbewh	227	31	influenza	influenza	NN
cord-289152-w5ynbewh	227	32	virus	virus	NN
cord-289152-w5ynbewh	227	33	(	(	-LRB-
cord-289152-w5ynbewh	227	34	Flory	Flory	NNP
cord-289152-w5ynbewh	227	35	et	et	FW
cord-289152-w5ynbewh	227	36	al	al	NNP
cord-289152-w5ynbewh	227	37	.	.	NNP
cord-289152-w5ynbewh	227	38	,	,	,
cord-289152-w5ynbewh	227	39	2000	2000	CD
cord-289152-w5ynbewh	227	40	)	)	-RRB-
cord-289152-w5ynbewh	227	41	,	,	,
cord-289152-w5ynbewh	227	42	hepatitis	hepatitis	NNP
cord-289152-w5ynbewh	227	43	B	B	NNP
cord-289152-w5ynbewh	227	44	virus	virus	NN
cord-289152-w5ynbewh	227	45	(	(	-LRB-
cord-289152-w5ynbewh	227	46	HBV	HBV	NNP
cord-289152-w5ynbewh	227	47	)	)	-RRB-
cord-289152-w5ynbewh	227	48	,	,	,
cord-289152-w5ynbewh	227	49	hepatitis	hepatitis	NN
cord-289152-w5ynbewh	227	50	C	C	NNP
cord-289152-w5ynbewh	227	51	virus	virus	NN
cord-289152-w5ynbewh	227	52	(	(	-LRB-
cord-289152-w5ynbewh	227	53	HCV	HCV	NNP
cord-289152-w5ynbewh	227	54	)	)	-RRB-
cord-289152-w5ynbewh	228	1	(	(	-LRB-
cord-289152-w5ynbewh	228	2	Gong	Gong	NNP
cord-289152-w5ynbewh	228	3	et	et	FW
cord-289152-w5ynbewh	228	4	al	al	NNP
cord-289152-w5ynbewh	228	5	.	.	NNP
cord-289152-w5ynbewh	228	6	,	,	,
cord-289152-w5ynbewh	228	7	2001	2001	CD
cord-289152-w5ynbewh	228	8	)	)	-RRB-
cord-289152-w5ynbewh	228	9	,	,	,
cord-289152-w5ynbewh	228	10	Japanese	japanese	JJ
cord-289152-w5ynbewh	228	11	encephalitis	encephalitis	NN
cord-289152-w5ynbewh	228	12	virus	virus	NN
cord-289152-w5ynbewh	228	13	(	(	-LRB-
cord-289152-w5ynbewh	228	14	Lin	Lin	NNP
cord-289152-w5ynbewh	228	15	et	et	NNP
cord-289152-w5ynbewh	228	16	al	al	NNP
cord-289152-w5ynbewh	228	17	.	.	NNP
cord-289152-w5ynbewh	228	18	,	,	,
cord-289152-w5ynbewh	228	19	2004	2004	CD
cord-289152-w5ynbewh	228	20	)	)	-RRB-
cord-289152-w5ynbewh	228	21	,	,	,
cord-289152-w5ynbewh	228	22	and	and	CC
cord-289152-w5ynbewh	228	23	herpes	herpes	NNP
cord-289152-w5ynbewh	228	24	simplex	simplex	NNP
cord-289152-w5ynbewh	228	25	virus	virus	NN
cord-289152-w5ynbewh	229	1	(	(	-LRB-
cord-289152-w5ynbewh	229	2	Mogensen	Mogensen	NNP
cord-289152-w5ynbewh	229	3	et	et	NNP
cord-289152-w5ynbewh	229	4	al	al	NNP
cord-289152-w5ynbewh	229	5	.	.	NNP
cord-289152-w5ynbewh	229	6	,	,	,
cord-289152-w5ynbewh	229	7	2003	2003	CD
cord-289152-w5ynbewh	229	8	)	)	-RRB-
cord-289152-w5ynbewh	229	9	activate	activate	VBP
cord-289152-w5ynbewh	229	10	the	the	DT
cord-289152-w5ynbewh	229	11	NF	nf	NN
cord-289152-w5ynbewh	229	12	-	-	HYPH
cord-289152-w5ynbewh	229	13	nB	nB	NNP
cord-289152-w5ynbewh	229	14	pathway	pathway	NN
cord-289152-w5ynbewh	229	15	through	through	IN
cord-289152-w5ynbewh	229	16	ROS	ROS	NNP
cord-289152-w5ynbewh	229	17	production	production	NN
cord-289152-w5ynbewh	229	18	.	.	.
cord-289152-w5ynbewh	230	1	Our	-PRON-	PRP$
cord-289152-w5ynbewh	230	2	study	study	NN
cord-289152-w5ynbewh	230	3	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	230	4	that	that	IN
cord-289152-w5ynbewh	230	5	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	230	6	generated	generate	VBD
cord-289152-w5ynbewh	230	7	ROS	ROS	NNP
cord-289152-w5ynbewh	230	8	,	,	,
cord-289152-w5ynbewh	230	9	and	and	CC
cord-289152-w5ynbewh	230	10	the	the	DT
cord-289152-w5ynbewh	230	11	involvement	involvement	NN
cord-289152-w5ynbewh	230	12	of	of	IN
cord-289152-w5ynbewh	230	13	ROS	ROS	NNP
cord-289152-w5ynbewh	230	14	in	in	IN
cord-289152-w5ynbewh	230	15	NF	nf	NN
cord-289152-w5ynbewh	230	16	-	-	HYPH
cord-289152-w5ynbewh	230	17	nB	nB	NNP
cord-289152-w5ynbewh	230	18	activation	activation	NN
cord-289152-w5ynbewh	230	19	by	by	IN
cord-289152-w5ynbewh	230	20	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	230	21	was	be	VBD
cord-289152-w5ynbewh	230	22	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	230	23	by	by	IN
cord-289152-w5ynbewh	230	24	reduced	reduce	VBN
cord-289152-w5ynbewh	230	25	NF	nf	NN
cord-289152-w5ynbewh	230	26	-	-	HYPH
cord-289152-w5ynbewh	230	27	nB	nb	NN
cord-289152-w5ynbewh	230	28	binding	bind	VBG
cord-289152-w5ynbewh	230	29	activity	activity	NN
cord-289152-w5ynbewh	230	30	in	in	IN
cord-289152-w5ynbewh	230	31	the	the	DT
cord-289152-w5ynbewh	230	32	presence	presence	NN
cord-289152-w5ynbewh	230	33	of	of	IN
cord-289152-w5ynbewh	230	34	PDTC	PDTC	NNP
cord-289152-w5ynbewh	230	35	and	and	CC
cord-289152-w5ynbewh	230	36	NAC	NAC	NNP
cord-289152-w5ynbewh	230	37	.	.	.
cord-289152-w5ynbewh	231	1	It	-PRON-	PRP
cord-289152-w5ynbewh	231	2	has	have	VBZ
cord-289152-w5ynbewh	231	3	been	be	VBN
cord-289152-w5ynbewh	231	4	shown	show	VBN
cord-289152-w5ynbewh	231	5	that	that	IN
cord-289152-w5ynbewh	231	6	oxidative	oxidative	JJ
cord-289152-w5ynbewh	231	7	stress	stress	NN
cord-289152-w5ynbewh	231	8	induced	induce	VBN
cord-289152-w5ynbewh	231	9	by	by	IN
cord-289152-w5ynbewh	231	10	ROS	ROS	NNP
cord-289152-w5ynbewh	231	11	is	be	VBZ
cord-289152-w5ynbewh	231	12	associated	associate	VBN
cord-289152-w5ynbewh	231	13	with	with	IN
cord-289152-w5ynbewh	231	14	viral	viral	JJ
cord-289152-w5ynbewh	231	15	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	231	16	in	in	IN
cord-289152-w5ynbewh	231	17	case	case	NN
cord-289152-w5ynbewh	231	18	of	of	IN
cord-289152-w5ynbewh	231	19	influenza	influenza	NN
cord-289152-w5ynbewh	231	20	virus	virus	NN
cord-289152-w5ynbewh	231	21	and	and	CC
cord-289152-w5ynbewh	231	22	HIV	HIV	NNP
cord-289152-w5ynbewh	231	23	(	(	-LRB-
cord-289152-w5ynbewh	231	24	Peterhans	Peterhans	NNP
cord-289152-w5ynbewh	231	25	,	,	,
cord-289152-w5ynbewh	231	26	1997	1997	CD
cord-289152-w5ynbewh	231	27	;	;	:
cord-289152-w5ynbewh	231	28	Schwarz	Schwarz	NNP
cord-289152-w5ynbewh	231	29	,	,	,
cord-289152-w5ynbewh	231	30	1996	1996	CD
cord-289152-w5ynbewh	231	31	)	)	-RRB-
cord-289152-w5ynbewh	231	32	.	.	.
cord-289152-w5ynbewh	232	1	However	however	RB
cord-289152-w5ynbewh	232	2	,	,	,
cord-289152-w5ynbewh	232	3	the	the	DT
cord-289152-w5ynbewh	232	4	role	role	NN
cord-289152-w5ynbewh	232	5	of	of	IN
cord-289152-w5ynbewh	232	6	ROS	ROS	NNP
cord-289152-w5ynbewh	232	7	in	in	IN
cord-289152-w5ynbewh	232	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	232	9	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	232	10	remains	remain	VBZ
cord-289152-w5ynbewh	232	11	to	to	TO
cord-289152-w5ynbewh	232	12	be	be	VB
cord-289152-w5ynbewh	232	13	elucidated	elucidate	VBN
cord-289152-w5ynbewh	232	14	.	.	.
cord-289152-w5ynbewh	233	1	Viruses	virus	NNS
cord-289152-w5ynbewh	233	2	modulate	modulate	VBP
cord-289152-w5ynbewh	233	3	NF	nf	NN
cord-289152-w5ynbewh	233	4	-	-	HYPH
cord-289152-w5ynbewh	233	5	nB	nB	NNP
cord-289152-w5ynbewh	233	6	activation	activation	NN
cord-289152-w5ynbewh	233	7	through	through	IN
cord-289152-w5ynbewh	233	8	various	various	JJ
cord-289152-w5ynbewh	233	9	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	233	10	.	.	.
cord-289152-w5ynbewh	234	1	Activation	activation	NN
cord-289152-w5ynbewh	234	2	of	of	IN
cord-289152-w5ynbewh	234	3	NF	nf	NN
cord-289152-w5ynbewh	234	4	-	-	HYPH
cord-289152-w5ynbewh	234	5	nB	nB	NNP
cord-289152-w5ynbewh	234	6	is	be	VBZ
cord-289152-w5ynbewh	234	7	usually	usually	RB
cord-289152-w5ynbewh	234	8	mediated	mediate	VBN
cord-289152-w5ynbewh	234	9	by	by	IN
cord-289152-w5ynbewh	234	10	degradation	degradation	NN
cord-289152-w5ynbewh	234	11	of	of	IN
cord-289152-w5ynbewh	234	12	InBa	InBa	NNP
cord-289152-w5ynbewh	234	13	in	in	IN
cord-289152-w5ynbewh	234	14	a	a	DT
cord-289152-w5ynbewh	234	15	proteasome	proteasome	VBN
cord-289152-w5ynbewh	234	16	-	-	HYPH
cord-289152-w5ynbewh	234	17	dependent	dependent	JJ
cord-289152-w5ynbewh	234	18	mechanism	mechanism	NN
cord-289152-w5ynbewh	234	19	after	after	IN
cord-289152-w5ynbewh	234	20	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	234	21	by	by	IN
cord-289152-w5ynbewh	234	22	IKK	IKK	NNP
cord-289152-w5ynbewh	234	23	(	(	-LRB-
cord-289152-w5ynbewh	234	24	Hayden	Hayden	NNP
cord-289152-w5ynbewh	234	25	and	and	CC
cord-289152-w5ynbewh	234	26	Ghosh	Ghosh	NNP
cord-289152-w5ynbewh	234	27	,	,	,
cord-289152-w5ynbewh	234	28	2004	2004	CD
cord-289152-w5ynbewh	234	29	)	)	-RRB-
cord-289152-w5ynbewh	234	30	.	.	.
cord-289152-w5ynbewh	235	1	InBa	InBa	NNP
cord-289152-w5ynbewh	235	2	is	be	VBZ
cord-289152-w5ynbewh	235	3	generally	generally	RB
cord-289152-w5ynbewh	235	4	thought	think	VBN
cord-289152-w5ynbewh	235	5	to	to	TO
cord-289152-w5ynbewh	235	6	be	be	VB
cord-289152-w5ynbewh	235	7	the	the	DT
cord-289152-w5ynbewh	235	8	major	major	JJ
cord-289152-w5ynbewh	235	9	inhibitor	inhibitor	NN
cord-289152-w5ynbewh	235	10	of	of	IN
cord-289152-w5ynbewh	235	11	NF	NF	NNP
cord-289152-w5ynbewh	235	12	-	-	HYPH
cord-289152-w5ynbewh	235	13	nB	nB	NNP
cord-289152-w5ynbewh	235	14	activation	activation	NN
cord-289152-w5ynbewh	235	15	.	.	.
cord-289152-w5ynbewh	236	1	NF	NF	NNP
cord-289152-w5ynbewh	236	2	-	-	HYPH
cord-289152-w5ynbewh	236	3	nB	nB	NNP
cord-289152-w5ynbewh	236	4	activation	activation	NN
cord-289152-w5ynbewh	236	5	by	by	IN
cord-289152-w5ynbewh	236	6	influenza	influenza	NN
cord-289152-w5ynbewh	236	7	virus	virus	NN
cord-289152-w5ynbewh	236	8	is	be	VBZ
cord-289152-w5ynbewh	236	9	mediated	mediate	VBN
cord-289152-w5ynbewh	236	10	by	by	IN
cord-289152-w5ynbewh	236	11	oxidative	oxidative	JJ
cord-289152-w5ynbewh	236	12	radicals	radical	NNS
cord-289152-w5ynbewh	236	13	and	and	CC
cord-289152-w5ynbewh	236	14	activation	activation	NN
cord-289152-w5ynbewh	236	15	of	of	IN
cord-289152-w5ynbewh	236	16	IKK	IKK	NNP
cord-289152-w5ynbewh	236	17	as	as	IN
cord-289152-w5ynbewh	236	18	a	a	DT
cord-289152-w5ynbewh	236	19	result	result	NN
cord-289152-w5ynbewh	236	20	of	of	IN
cord-289152-w5ynbewh	236	21	overexpression	overexpression	NN
cord-289152-w5ynbewh	236	22	of	of	IN
cord-289152-w5ynbewh	236	23	viral	viral	JJ
cord-289152-w5ynbewh	236	24	proteins	protein	NNS
cord-289152-w5ynbewh	236	25	in	in	IN
cord-289152-w5ynbewh	236	26	endoplasmic	endoplasmic	NN
cord-289152-w5ynbewh	236	27	reticulum	reticulum	NN
cord-289152-w5ynbewh	236	28	(	(	-LRB-
cord-289152-w5ynbewh	236	29	Flory	Flory	NNP
cord-289152-w5ynbewh	236	30	et	et	FW
cord-289152-w5ynbewh	236	31	al	al	NNP
cord-289152-w5ynbewh	236	32	.	.	NNP
cord-289152-w5ynbewh	236	33	,	,	,
cord-289152-w5ynbewh	236	34	2000	2000	CD
cord-289152-w5ynbewh	236	35	)	)	-RRB-
cord-289152-w5ynbewh	236	36	.	.	.
cord-289152-w5ynbewh	237	1	The	the	DT
cord-289152-w5ynbewh	237	2	Tax	Tax	NNP
cord-289152-w5ynbewh	237	3	transactivator	transactivator	NN
cord-289152-w5ynbewh	237	4	oncoprotein	oncoprotein	NNP
cord-289152-w5ynbewh	237	5	of	of	IN
cord-289152-w5ynbewh	237	6	human	human	NNP
cord-289152-w5ynbewh	237	7	T	T	NNP
cord-289152-w5ynbewh	237	8	-	-	HYPH
cord-289152-w5ynbewh	237	9	lymphotropic	lymphotropic	NNP
cord-289152-w5ynbewh	237	10	virus-1	virus-1	NN
cord-289152-w5ynbewh	237	11	activates	activate	VBZ
cord-289152-w5ynbewh	237	12	NF	NF	NNP
cord-289152-w5ynbewh	237	13	-	-	HYPH
cord-289152-w5ynbewh	237	14	nB	nB	NNP
cord-289152-w5ynbewh	237	15	by	by	IN
cord-289152-w5ynbewh	237	16	interacting	interact	VBG
cord-289152-w5ynbewh	237	17	directly	directly	RB
cord-289152-w5ynbewh	237	18	with	with	IN
cord-289152-w5ynbewh	237	19	IKK	IKK	NNP
cord-289152-w5ynbewh	237	20	(	(	-LRB-
cord-289152-w5ynbewh	237	21	O'Mahony	O'Mahony	NNP
cord-289152-w5ynbewh	237	22	et	et	NNP
cord-289152-w5ynbewh	237	23	al	al	NNP
cord-289152-w5ynbewh	237	24	.	.	NNP
cord-289152-w5ynbewh	237	25	,	,	,
cord-289152-w5ynbewh	237	26	2004	2004	CD
cord-289152-w5ynbewh	237	27	)	)	-RRB-
cord-289152-w5ynbewh	237	28	.	.	.
cord-289152-w5ynbewh	238	1	HSV-1	hsv-1	NN
cord-289152-w5ynbewh	238	2	induces	induce	VBZ
cord-289152-w5ynbewh	238	3	persistent	persistent	JJ
cord-289152-w5ynbewh	238	4	translocation	translocation	NN
cord-289152-w5ynbewh	238	5	of	of	IN
cord-289152-w5ynbewh	238	6	NF	nf	NN
cord-289152-w5ynbewh	238	7	-	-	HYPH
cord-289152-w5ynbewh	238	8	nB	nB	NNP
cord-289152-w5ynbewh	238	9	by	by	IN
cord-289152-w5ynbewh	238	10	InBa	InBa	NNP
cord-289152-w5ynbewh	238	11	degradation	degradation	NN
cord-289152-w5ynbewh	238	12	(	(	-LRB-
cord-289152-w5ynbewh	238	13	Patel	Patel	NNP
cord-289152-w5ynbewh	238	14	et	et	NNP
cord-289152-w5ynbewh	238	15	al	al	NNP
cord-289152-w5ynbewh	238	16	.	.	NNP
cord-289152-w5ynbewh	238	17	,	,	,
cord-289152-w5ynbewh	238	18	1998	1998	CD
cord-289152-w5ynbewh	238	19	)	)	-RRB-
cord-289152-w5ynbewh	238	20	.	.	.
cord-289152-w5ynbewh	239	1	In	in	IN
cord-289152-w5ynbewh	239	2	this	this	DT
cord-289152-w5ynbewh	239	3	study	study	NN
cord-289152-w5ynbewh	239	4	,	,	,
cord-289152-w5ynbewh	239	5	Western	western	JJ
cord-289152-w5ynbewh	239	6	blot	blot	NN
cord-289152-w5ynbewh	239	7	analysis	analysis	NN
cord-289152-w5ynbewh	239	8	of	of	IN
cord-289152-w5ynbewh	239	9	InB	inb	NN
cord-289152-w5ynbewh	239	10	protein	protein	NN
cord-289152-w5ynbewh	239	11	levels	level	NNS
cord-289152-w5ynbewh	239	12	revealed	reveal	VBD
cord-289152-w5ynbewh	239	13	that	that	IN
cord-289152-w5ynbewh	239	14	InBa	InBa	NNP
cord-289152-w5ynbewh	239	15	protein	protein	NN
cord-289152-w5ynbewh	239	16	was	be	VBD
cord-289152-w5ynbewh	239	17	degraded	degrade	VBN
cord-289152-w5ynbewh	239	18	in	in	IN
cord-289152-w5ynbewh	239	19	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	239	20	-	-	HYPH
cord-289152-w5ynbewh	239	21	infected	infect	VBN
cord-289152-w5ynbewh	239	22	cells	cell	NNS
cord-289152-w5ynbewh	239	23	and	and	CC
cord-289152-w5ynbewh	239	24	the	the	DT
cord-289152-w5ynbewh	239	25	expression	expression	NN
cord-289152-w5ynbewh	239	26	of	of	IN
cord-289152-w5ynbewh	239	27	InBa	InBa	NNP
cord-289152-w5ynbewh	239	28	-	-	HYPH
cord-289152-w5ynbewh	239	29	DN	DN	NNP
cord-289152-w5ynbewh	239	30	eliminated	eliminate	VBD
cord-289152-w5ynbewh	239	31	NF	nf	NN
cord-289152-w5ynbewh	239	32	-	-	HYPH
cord-289152-w5ynbewh	239	33	nB	nB	NNP
cord-289152-w5ynbewh	239	34	activation	activation	NN
cord-289152-w5ynbewh	239	35	by	by	IN
cord-289152-w5ynbewh	239	36	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	239	37	.	.	.
cord-289152-w5ynbewh	240	1	This	this	DT
cord-289152-w5ynbewh	240	2	finding	finding	NN
cord-289152-w5ynbewh	240	3	demonstrates	demonstrate	VBZ
cord-289152-w5ynbewh	240	4	that	that	IN
cord-289152-w5ynbewh	240	5	NF	nf	NN
cord-289152-w5ynbewh	240	6	-	-	HYPH
cord-289152-w5ynbewh	240	7	nB	nB	NNP
cord-289152-w5ynbewh	240	8	activation	activation	NN
cord-289152-w5ynbewh	240	9	by	by	IN
cord-289152-w5ynbewh	240	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	240	11	is	be	VBZ
cord-289152-w5ynbewh	240	12	mediated	mediate	VBN
cord-289152-w5ynbewh	240	13	at	at	IN
cord-289152-w5ynbewh	240	14	least	least	JJS
cord-289152-w5ynbewh	240	15	in	in	IN
cord-289152-w5ynbewh	240	16	part	part	NN
cord-289152-w5ynbewh	240	17	by	by	IN
cord-289152-w5ynbewh	240	18	InBa	InBa	NNP
cord-289152-w5ynbewh	240	19	degradation	degradation	NN
cord-289152-w5ynbewh	240	20	in	in	IN
cord-289152-w5ynbewh	240	21	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	240	22	cells	cell	NNS
cord-289152-w5ynbewh	240	23	and	and	CC
cord-289152-w5ynbewh	240	24	the	the	DT
cord-289152-w5ynbewh	240	25	degradation	degradation	NN
cord-289152-w5ynbewh	240	26	of	of	IN
cord-289152-w5ynbewh	240	27	InBa	InBa	NNP
cord-289152-w5ynbewh	240	28	,	,	,
cord-289152-w5ynbewh	240	29	InBh	InBh	NNP
cord-289152-w5ynbewh	240	30	,	,	,
cord-289152-w5ynbewh	240	31	and	and	CC
cord-289152-w5ynbewh	240	32	InBe	InBe	NNP
cord-289152-w5ynbewh	240	33	in	in	IN
cord-289152-w5ynbewh	240	34	PAM	PAM	NNP
cord-289152-w5ynbewh	240	35	cultures	culture	NNS
cord-289152-w5ynbewh	240	36	.	.	.
cord-289152-w5ynbewh	241	1	This	this	DT
cord-289152-w5ynbewh	241	2	result	result	NN
cord-289152-w5ynbewh	241	3	indicates	indicate	VBZ
cord-289152-w5ynbewh	241	4	the	the	DT
cord-289152-w5ynbewh	241	5	possibility	possibility	NN
cord-289152-w5ynbewh	241	6	that	that	IN
cord-289152-w5ynbewh	241	7	different	different	JJ
cord-289152-w5ynbewh	241	8	molecules	molecule	NNS
cord-289152-w5ynbewh	241	9	are	be	VBP
cord-289152-w5ynbewh	241	10	involved	involve	VBN
cord-289152-w5ynbewh	241	11	in	in	IN
cord-289152-w5ynbewh	241	12	NF	nf	NN
cord-289152-w5ynbewh	241	13	-	-	HYPH
cord-289152-w5ynbewh	241	14	nB	nB	NNP
cord-289152-w5ynbewh	241	15	activation	activation	NN
cord-289152-w5ynbewh	241	16	in	in	IN
cord-289152-w5ynbewh	241	17	PAM	PAM	NNP
cord-289152-w5ynbewh	241	18	culture	culture	NN
cord-289152-w5ynbewh	241	19	infected	infect	VBN
cord-289152-w5ynbewh	241	20	with	with	IN
cord-289152-w5ynbewh	241	21	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	241	22	compared	compare	VBN
cord-289152-w5ynbewh	241	23	to	to	IN
cord-289152-w5ynbewh	241	24	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	241	25	cells	cell	NNS
cord-289152-w5ynbewh	241	26	.	.	.
cord-289152-w5ynbewh	242	1	However	however	RB
cord-289152-w5ynbewh	242	2	,	,	,
cord-289152-w5ynbewh	242	3	the	the	DT
cord-289152-w5ynbewh	242	4	precise	precise	JJ
cord-289152-w5ynbewh	242	5	mechanism	mechanism	NN
cord-289152-w5ynbewh	242	6	through	through	IN
cord-289152-w5ynbewh	242	7	which	which	WDT
cord-289152-w5ynbewh	242	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	242	9	influences	influence	VBZ
cord-289152-w5ynbewh	242	10	the	the	DT
cord-289152-w5ynbewh	242	11	InB	inb	NN
cord-289152-w5ynbewh	242	12	degradation	degradation	NN
cord-289152-w5ynbewh	242	13	in	in	IN
cord-289152-w5ynbewh	242	14	both	both	DT
cord-289152-w5ynbewh	242	15	cells	cell	NNS
cord-289152-w5ynbewh	242	16	is	be	VBZ
cord-289152-w5ynbewh	242	17	presently	presently	RB
cord-289152-w5ynbewh	242	18	unknown	unknown	JJ
cord-289152-w5ynbewh	242	19	.	.	.
cord-289152-w5ynbewh	243	1	Some	some	DT
cord-289152-w5ynbewh	243	2	viruses	virus	NNS
cord-289152-w5ynbewh	243	3	activate	activate	VBP
cord-289152-w5ynbewh	243	4	the	the	DT
cord-289152-w5ynbewh	243	5	NF	nf	NN
cord-289152-w5ynbewh	243	6	-	-	HYPH
cord-289152-w5ynbewh	243	7	nB	nB	NNP
cord-289152-w5ynbewh	243	8	pathway	pathway	NN
cord-289152-w5ynbewh	243	9	through	through	IN
cord-289152-w5ynbewh	243	10	viral	viral	JJ
cord-289152-w5ynbewh	243	11	protein	protein	NN
cord-289152-w5ynbewh	243	12	-	-	HYPH
cord-289152-w5ynbewh	243	13	cellular	cellular	JJ
cord-289152-w5ynbewh	243	14	receptor	receptor	NN
cord-289152-w5ynbewh	243	15	interaction	interaction	NN
cord-289152-w5ynbewh	243	16	.	.	.
cord-289152-w5ynbewh	244	1	For	for	IN
cord-289152-w5ynbewh	244	2	instance	instance	NN
cord-289152-w5ynbewh	244	3	,	,	,
cord-289152-w5ynbewh	244	4	HIV	HIV	NNP
cord-289152-w5ynbewh	244	5	gp120	gp120	NNP
cord-289152-w5ynbewh	244	6	and	and	CC
cord-289152-w5ynbewh	244	7	EBV	EBV	NNP
cord-289152-w5ynbewh	244	8	gp350	gp350	NNP
cord-289152-w5ynbewh	244	9	activate	activate	VBP
cord-289152-w5ynbewh	244	10	NF	NF	NNP
cord-289152-w5ynbewh	244	11	-	-	HYPH
cord-289152-w5ynbewh	244	12	nB	nB	NNP
cord-289152-w5ynbewh	244	13	signaling	signal	VBG
cord-289152-w5ynbewh	244	14	pathway	pathway	NN
cord-289152-w5ynbewh	244	15	through	through	IN
cord-289152-w5ynbewh	244	16	binding	bind	VBG
cord-289152-w5ynbewh	244	17	to	to	IN
cord-289152-w5ynbewh	244	18	CD4	CD4	NNP
cord-289152-w5ynbewh	244	19	and	and	CC
cord-289152-w5ynbewh	244	20	CD21	CD21	NNP
cord-289152-w5ynbewh	245	1	(	(	-LRB-
cord-289152-w5ynbewh	245	2	Bossis	Bossis	NNP
cord-289152-w5ynbewh	245	3	et	et	NNP
cord-289152-w5ynbewh	245	4	al	al	NNP
cord-289152-w5ynbewh	245	5	.	.	NNP
cord-289152-w5ynbewh	245	6	,	,	,
cord-289152-w5ynbewh	245	7	2002	2002	CD
cord-289152-w5ynbewh	245	8	;	;	:
cord-289152-w5ynbewh	246	1	D'Addario	D'Addario	NNP
cord-289152-w5ynbewh	246	2	et	et	NNP
cord-289152-w5ynbewh	246	3	al	al	NNP
cord-289152-w5ynbewh	246	4	.	.	NNP
cord-289152-w5ynbewh	246	5	,	,	,
cord-289152-w5ynbewh	246	6	1999	1999	CD
cord-289152-w5ynbewh	246	7	;	;	:
cord-289152-w5ynbewh	246	8	Sugano	Sugano	NNP
cord-289152-w5ynbewh	246	9	et	et	FW
cord-289152-w5ynbewh	246	10	al	al	NNP
cord-289152-w5ynbewh	246	11	.	.	NNP
cord-289152-w5ynbewh	246	12	,	,	,
cord-289152-w5ynbewh	246	13	1997	1997	CD
cord-289152-w5ynbewh	246	14	)	)	-RRB-
cord-289152-w5ynbewh	246	15	.	.	.
cord-289152-w5ynbewh	247	1	However	however	RB
cord-289152-w5ynbewh	247	2	,	,	,
cord-289152-w5ynbewh	247	3	it	-PRON-	PRP
cord-289152-w5ynbewh	247	4	is	be	VBZ
cord-289152-w5ynbewh	247	5	unlikely	unlikely	JJ
cord-289152-w5ynbewh	247	6	that	that	IN
cord-289152-w5ynbewh	247	7	NF	nf	NN
cord-289152-w5ynbewh	247	8	-	-	HYPH
cord-289152-w5ynbewh	247	9	nB	nB	NNP
cord-289152-w5ynbewh	247	10	activation	activation	NN
cord-289152-w5ynbewh	247	11	by	by	IN
cord-289152-w5ynbewh	247	12	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	247	13	is	be	VBZ
cord-289152-w5ynbewh	247	14	triggered	trigger	VBN
cord-289152-w5ynbewh	247	15	solely	solely	RB
cord-289152-w5ynbewh	247	16	by	by	IN
cord-289152-w5ynbewh	247	17	viral	viral	JJ
cord-289152-w5ynbewh	247	18	binding	binding	NN
cord-289152-w5ynbewh	247	19	to	to	IN
cord-289152-w5ynbewh	247	20	its	-PRON-	PRP$
cord-289152-w5ynbewh	247	21	cognate	cognate	JJ
cord-289152-w5ynbewh	247	22	cellular	cellular	JJ
cord-289152-w5ynbewh	247	23	receptor	receptor	NN
cord-289152-w5ynbewh	247	24	because	because	IN
cord-289152-w5ynbewh	247	25	the	the	DT
cord-289152-w5ynbewh	247	26	level	level	NN
cord-289152-w5ynbewh	247	27	of	of	IN
cord-289152-w5ynbewh	247	28	NF	nf	NN
cord-289152-w5ynbewh	247	29	-	-	HYPH
cord-289152-w5ynbewh	247	30	nB	nB	NNP
cord-289152-w5ynbewh	247	31	activation	activation	NN
cord-289152-w5ynbewh	247	32	by	by	IN
cord-289152-w5ynbewh	247	33	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	247	34	increased	increase	VBD
cord-289152-w5ynbewh	247	35	as	as	IN
cord-289152-w5ynbewh	247	36	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	247	37	replication	replication	NN
cord-289152-w5ynbewh	247	38	progression	progression	NN
cord-289152-w5ynbewh	247	39	was	be	VBD
cord-289152-w5ynbewh	247	40	significantly	significantly	RB
cord-289152-w5ynbewh	247	41	reduced	reduce	VBN
cord-289152-w5ynbewh	247	42	by	by	IN
cord-289152-w5ynbewh	247	43	UV	uv	NN
cord-289152-w5ynbewh	247	44	-	-	HYPH
cord-289152-w5ynbewh	247	45	inactivation	inactivation	NN
cord-289152-w5ynbewh	247	46	of	of	IN
cord-289152-w5ynbewh	247	47	virus	virus	NN
cord-289152-w5ynbewh	247	48	.	.	.
cord-289152-w5ynbewh	248	1	Therefore	therefore	RB
cord-289152-w5ynbewh	248	2	,	,	,
cord-289152-w5ynbewh	248	3	it	-PRON-	PRP
cord-289152-w5ynbewh	248	4	is	be	VBZ
cord-289152-w5ynbewh	248	5	possible	possible	JJ
cord-289152-w5ynbewh	248	6	that	that	IN
cord-289152-w5ynbewh	248	7	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	248	8	replication	replication	NN
cord-289152-w5ynbewh	248	9	or	or	CC
cord-289152-w5ynbewh	248	10	viral	viral	JJ
cord-289152-w5ynbewh	248	11	protein	protein	NN
cord-289152-w5ynbewh	248	12	expression	expression	NN
cord-289152-w5ynbewh	248	13	is	be	VBZ
cord-289152-w5ynbewh	248	14	a	a	DT
cord-289152-w5ynbewh	248	15	prerequisite	prerequisite	NN
cord-289152-w5ynbewh	248	16	for	for	IN
cord-289152-w5ynbewh	248	17	activation	activation	NN
cord-289152-w5ynbewh	248	18	of	of	IN
cord-289152-w5ynbewh	248	19	the	the	DT
cord-289152-w5ynbewh	248	20	NF	nf	NN
cord-289152-w5ynbewh	248	21	-	-	HYPH
cord-289152-w5ynbewh	248	22	nB	nB	NNP
cord-289152-w5ynbewh	248	23	pathway	pathway	NN
cord-289152-w5ynbewh	248	24	.	.	.
cord-289152-w5ynbewh	249	1	Alternatively	alternatively	RB
cord-289152-w5ynbewh	249	2	,	,	,
cord-289152-w5ynbewh	249	3	a	a	DT
cord-289152-w5ynbewh	249	4	soluble	soluble	JJ
cord-289152-w5ynbewh	249	5	factor	factor	NN
cord-289152-w5ynbewh	249	6	induced	induce	VBN
cord-289152-w5ynbewh	249	7	by	by	IN
cord-289152-w5ynbewh	249	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	249	9	could	could	MD
cord-289152-w5ynbewh	249	10	be	be	VB
cord-289152-w5ynbewh	249	11	responsible	responsible	JJ
cord-289152-w5ynbewh	249	12	for	for	IN
cord-289152-w5ynbewh	249	13	the	the	DT
cord-289152-w5ynbewh	249	14	delayed	delay	VBN
cord-289152-w5ynbewh	249	15	NF	nf	NN
cord-289152-w5ynbewh	249	16	-	-	HYPH
cord-289152-w5ynbewh	249	17	nB	nB	NNP
cord-289152-w5ynbewh	249	18	activation	activation	NN
cord-289152-w5ynbewh	249	19	.	.	.
cord-289152-w5ynbewh	250	1	Previous	previous	JJ
cord-289152-w5ynbewh	250	2	studies	study	NNS
cord-289152-w5ynbewh	250	3	have	have	VBP
cord-289152-w5ynbewh	250	4	demonstrated	demonstrate	VBN
cord-289152-w5ynbewh	250	5	a	a	DT
cord-289152-w5ynbewh	250	6	requirement	requirement	NN
cord-289152-w5ynbewh	250	7	for	for	IN
cord-289152-w5ynbewh	250	8	NF	nf	NN
cord-289152-w5ynbewh	250	9	-	-	HYPH
cord-289152-w5ynbewh	250	10	nB	nB	NNP
cord-289152-w5ynbewh	250	11	activation	activation	NN
cord-289152-w5ynbewh	250	12	in	in	IN
cord-289152-w5ynbewh	250	13	viral	viral	JJ
cord-289152-w5ynbewh	250	14	replication	replication	NN
cord-289152-w5ynbewh	250	15	.	.	.
cord-289152-w5ynbewh	251	1	Influenza	influenza	NN
cord-289152-w5ynbewh	251	2	virus	virus	NN
cord-289152-w5ynbewh	251	3	infection	infection	NN
cord-289152-w5ynbewh	251	4	is	be	VBZ
cord-289152-w5ynbewh	251	5	dependent	dependent	JJ
cord-289152-w5ynbewh	251	6	on	on	IN
cord-289152-w5ynbewh	251	7	an	an	DT
cord-289152-w5ynbewh	251	8	active	active	JJ
cord-289152-w5ynbewh	251	9	NF	nf	NN
cord-289152-w5ynbewh	251	10	-	-	HYPH
cord-289152-w5ynbewh	251	11	nB	nB	NNP
cord-289152-w5ynbewh	251	12	signaling	signal	VBG
cord-289152-w5ynbewh	251	13	pathway	pathway	NN
cord-289152-w5ynbewh	251	14	(	(	-LRB-
cord-289152-w5ynbewh	251	15	Nimmerjahn	Nimmerjahn	NNP
cord-289152-w5ynbewh	251	16	et	et	NNP
cord-289152-w5ynbewh	251	17	al	al	NNP
cord-289152-w5ynbewh	251	18	.	.	NNP
cord-289152-w5ynbewh	251	19	,	,	,
cord-289152-w5ynbewh	251	20	2004	2004	CD
cord-289152-w5ynbewh	251	21	)	)	-RRB-
cord-289152-w5ynbewh	251	22	.	.	.
cord-289152-w5ynbewh	252	1	Inhibition	inhibition	NN
cord-289152-w5ynbewh	252	2	of	of	IN
cord-289152-w5ynbewh	252	3	NF	NF	NNP
cord-289152-w5ynbewh	252	4	-	-	HYPH
cord-289152-w5ynbewh	252	5	nB	nB	NNP
cord-289152-w5ynbewh	252	6	activation	activation	NN
cord-289152-w5ynbewh	252	7	blocked	block	VBN
cord-289152-w5ynbewh	252	8	influenza	influenza	NN
cord-289152-w5ynbewh	252	9	virus	virus	NN
cord-289152-w5ynbewh	252	10	infection	infection	NN
cord-289152-w5ynbewh	252	11	of	of	IN
cord-289152-w5ynbewh	252	12	susceptible	susceptible	JJ
cord-289152-w5ynbewh	252	13	cells	cell	NNS
cord-289152-w5ynbewh	252	14	,	,	,
cord-289152-w5ynbewh	252	15	and	and	CC
cord-289152-w5ynbewh	252	16	cells	cell	NNS
cord-289152-w5ynbewh	252	17	with	with	IN
cord-289152-w5ynbewh	252	18	low	low	JJ
cord-289152-w5ynbewh	252	19	NF	nf	NN
cord-289152-w5ynbewh	252	20	-	-	HYPH
cord-289152-w5ynbewh	252	21	nB	nb	NN
cord-289152-w5ynbewh	252	22	activity	activity	NN
cord-289152-w5ynbewh	252	23	were	be	VBD
cord-289152-w5ynbewh	252	24	poorly	poorly	RB
cord-289152-w5ynbewh	252	25	susceptible	susceptible	JJ
cord-289152-w5ynbewh	252	26	to	to	IN
cord-289152-w5ynbewh	252	27	influenza	influenza	NN
cord-289152-w5ynbewh	252	28	virus	virus	NN
cord-289152-w5ynbewh	252	29	infection	infection	NN
cord-289152-w5ynbewh	253	1	(	(	-LRB-
cord-289152-w5ynbewh	253	2	Nimmerjahn	Nimmerjahn	NNP
cord-289152-w5ynbewh	253	3	et	et	NNP
cord-289152-w5ynbewh	253	4	al	al	NNP
cord-289152-w5ynbewh	253	5	.	.	NNP
cord-289152-w5ynbewh	253	6	,	,	,
cord-289152-w5ynbewh	253	7	2004	2004	CD
cord-289152-w5ynbewh	253	8	)	)	-RRB-
cord-289152-w5ynbewh	253	9	.	.	.
cord-289152-w5ynbewh	254	1	Efficient	efficient	JJ
cord-289152-w5ynbewh	254	2	replication	replication	NN
cord-289152-w5ynbewh	254	3	of	of	IN
cord-289152-w5ynbewh	254	4	HSV-1	hsv-1	NN
cord-289152-w5ynbewh	254	5	is	be	VBZ
cord-289152-w5ynbewh	254	6	promoted	promote	VBN
cord-289152-w5ynbewh	254	7	by	by	IN
cord-289152-w5ynbewh	254	8	NF	NF	NNP
cord-289152-w5ynbewh	254	9	-	-	HYPH
cord-289152-w5ynbewh	254	10	nB	nB	NNP
cord-289152-w5ynbewh	254	11	activation	activation	NN
cord-289152-w5ynbewh	254	12	through	through	IN
cord-289152-w5ynbewh	254	13	the	the	DT
cord-289152-w5ynbewh	254	14	InB	inb	NN
cord-289152-w5ynbewh	254	15	kinase	kinase	NN
cord-289152-w5ynbewh	254	16	-	-	HYPH
cord-289152-w5ynbewh	254	17	InB	inb	NN
cord-289152-w5ynbewh	254	18	-	-	HYPH
cord-289152-w5ynbewh	254	19	p65	p65	NN
cord-289152-w5ynbewh	254	20	pathway	pathway	NN
cord-289152-w5ynbewh	254	21	(	(	-LRB-
cord-289152-w5ynbewh	254	22	Gregory	Gregory	NNP
cord-289152-w5ynbewh	254	23	et	et	NNP
cord-289152-w5ynbewh	254	24	al	al	NNP
cord-289152-w5ynbewh	254	25	.	.	NNP
cord-289152-w5ynbewh	254	26	,	,	,
cord-289152-w5ynbewh	254	27	2004	2004	CD
cord-289152-w5ynbewh	254	28	)	)	-RRB-
cord-289152-w5ynbewh	254	29	.	.	.
cord-289152-w5ynbewh	255	1	However	however	RB
cord-289152-w5ynbewh	255	2	,	,	,
cord-289152-w5ynbewh	255	3	blocking	block	VBG
cord-289152-w5ynbewh	255	4	the	the	DT
cord-289152-w5ynbewh	255	5	NF	nf	NN
cord-289152-w5ynbewh	255	6	-	-	HYPH
cord-289152-w5ynbewh	255	7	nB	nB	NNP
cord-289152-w5ynbewh	255	8	pathway	pathway	NN
cord-289152-w5ynbewh	255	9	by	by	IN
cord-289152-w5ynbewh	255	10	overexpression	overexpression	NN
cord-289152-w5ynbewh	255	11	of	of	IN
cord-289152-w5ynbewh	255	12	dominant	dominant	JJ
cord-289152-w5ynbewh	255	13	negative	negative	JJ
cord-289152-w5ynbewh	255	14	forms	form	NNS
cord-289152-w5ynbewh	255	15	of	of	IN
cord-289152-w5ynbewh	255	16	InBa	InBa	NNP
cord-289152-w5ynbewh	255	17	did	do	VBD
cord-289152-w5ynbewh	255	18	not	not	RB
cord-289152-w5ynbewh	255	19	interfere	interfere	VB
cord-289152-w5ynbewh	255	20	with	with	IN
cord-289152-w5ynbewh	255	21	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	255	22	replication	replication	NN
cord-289152-w5ynbewh	255	23	,	,	,
cord-289152-w5ynbewh	255	24	suggesting	suggest	VBG
cord-289152-w5ynbewh	255	25	that	that	IN
cord-289152-w5ynbewh	255	26	activation	activation	NN
cord-289152-w5ynbewh	255	27	of	of	IN
cord-289152-w5ynbewh	255	28	the	the	DT
cord-289152-w5ynbewh	255	29	NF	nf	NN
cord-289152-w5ynbewh	255	30	-	-	HYPH
cord-289152-w5ynbewh	255	31	nB	nB	NNP
cord-289152-w5ynbewh	255	32	pathway	pathway	NN
cord-289152-w5ynbewh	255	33	is	be	VBZ
cord-289152-w5ynbewh	255	34	non	non	JJ
cord-289152-w5ynbewh	255	35	-	-	JJ
cord-289152-w5ynbewh	255	36	essential	essential	JJ
cord-289152-w5ynbewh	255	37	for	for	IN
cord-289152-w5ynbewh	255	38	efficient	efficient	JJ
cord-289152-w5ynbewh	255	39	viral	viral	JJ
cord-289152-w5ynbewh	255	40	replication	replication	NN
cord-289152-w5ynbewh	255	41	.	.	.
cord-289152-w5ynbewh	256	1	Similarly	similarly	RB
cord-289152-w5ynbewh	256	2	,	,	,
cord-289152-w5ynbewh	256	3	other	other	JJ
cord-289152-w5ynbewh	256	4	studies	study	NNS
cord-289152-w5ynbewh	256	5	with	with	IN
cord-289152-w5ynbewh	256	6	Japanese	japanese	JJ
cord-289152-w5ynbewh	256	7	encephalitis	encephalitis	JJ
cord-289152-w5ynbewh	256	8	virus	virus	NN
cord-289152-w5ynbewh	256	9	or	or	CC
cord-289152-w5ynbewh	256	10	cytomegalovirus	cytomegalovirus	NNP
cord-289152-w5ynbewh	256	11	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	256	12	that	that	IN
cord-289152-w5ynbewh	256	13	NF	nf	NN
cord-289152-w5ynbewh	256	14	-	-	HYPH
cord-289152-w5ynbewh	256	15	nB	nB	NNP
cord-289152-w5ynbewh	256	16	activation	activation	NN
cord-289152-w5ynbewh	256	17	is	be	VBZ
cord-289152-w5ynbewh	256	18	not	not	RB
cord-289152-w5ynbewh	256	19	required	require	VBN
cord-289152-w5ynbewh	256	20	for	for	IN
cord-289152-w5ynbewh	256	21	efficient	efficient	JJ
cord-289152-w5ynbewh	256	22	viral	viral	JJ
cord-289152-w5ynbewh	256	23	replication	replication	NN
cord-289152-w5ynbewh	256	24	(	(	-LRB-
cord-289152-w5ynbewh	256	25	Benedict	Benedict	NNP
cord-289152-w5ynbewh	256	26	et	et	NNP
cord-289152-w5ynbewh	256	27	al	al	NNP
cord-289152-w5ynbewh	256	28	.	.	NNP
cord-289152-w5ynbewh	256	29	,	,	,
cord-289152-w5ynbewh	256	30	2004	2004	CD
cord-289152-w5ynbewh	256	31	;	;	:
cord-289152-w5ynbewh	257	1	Liao	Liao	NNP
cord-289152-w5ynbewh	257	2	et	et	NNP
cord-289152-w5ynbewh	257	3	al	al	NNP
cord-289152-w5ynbewh	257	4	.	.	NNP
cord-289152-w5ynbewh	257	5	,	,	,
cord-289152-w5ynbewh	257	6	2001	2001	CD
cord-289152-w5ynbewh	257	7	)	)	-RRB-
cord-289152-w5ynbewh	257	8	.	.	.
cord-289152-w5ynbewh	258	1	Although	although	IN
cord-289152-w5ynbewh	258	2	NF	nf	NN
cord-289152-w5ynbewh	258	3	-	-	HYPH
cord-289152-w5ynbewh	258	4	nB	nB	NNP
cord-289152-w5ynbewh	258	5	activation	activation	NN
cord-289152-w5ynbewh	258	6	does	do	VBZ
cord-289152-w5ynbewh	258	7	not	not	RB
cord-289152-w5ynbewh	258	8	play	play	VB
cord-289152-w5ynbewh	258	9	an	an	DT
cord-289152-w5ynbewh	258	10	essential	essential	JJ
cord-289152-w5ynbewh	258	11	role	role	NN
cord-289152-w5ynbewh	258	12	in	in	IN
cord-289152-w5ynbewh	258	13	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	258	14	replication	replication	NN
cord-289152-w5ynbewh	258	15	in	in	IN
cord-289152-w5ynbewh	258	16	vitro	vitro	FW
cord-289152-w5ynbewh	258	17	,	,	,
cord-289152-w5ynbewh	258	18	it	-PRON-	PRP
cord-289152-w5ynbewh	258	19	does	do	VBZ
cord-289152-w5ynbewh	258	20	not	not	RB
cord-289152-w5ynbewh	258	21	mean	mean	VB
cord-289152-w5ynbewh	258	22	that	that	IN
cord-289152-w5ynbewh	258	23	NF	nf	NN
cord-289152-w5ynbewh	258	24	-	-	HYPH
cord-289152-w5ynbewh	258	25	nB	nB	NNP
cord-289152-w5ynbewh	258	26	has	have	VBZ
cord-289152-w5ynbewh	258	27	no	no	DT
cord-289152-w5ynbewh	258	28	contribution	contribution	NN
cord-289152-w5ynbewh	258	29	to	to	IN
cord-289152-w5ynbewh	258	30	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	258	31	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	258	32	in	in	IN
cord-289152-w5ynbewh	258	33	vivo	vivo	NN
cord-289152-w5ynbewh	258	34	.	.	.
cord-289152-w5ynbewh	259	1	Macrophages	macrophage	NNS
cord-289152-w5ynbewh	259	2	represent	represent	VBP
cord-289152-w5ynbewh	259	3	an	an	DT
cord-289152-w5ynbewh	259	4	important	important	JJ
cord-289152-w5ynbewh	259	5	source	source	NN
cord-289152-w5ynbewh	259	6	for	for	IN
cord-289152-w5ynbewh	259	7	a	a	DT
cord-289152-w5ynbewh	259	8	variety	variety	NN
cord-289152-w5ynbewh	259	9	of	of	IN
cord-289152-w5ynbewh	259	10	soluble	soluble	JJ
cord-289152-w5ynbewh	259	11	immune	immune	JJ
cord-289152-w5ynbewh	259	12	mediators	mediator	NNS
cord-289152-w5ynbewh	259	13	,	,	,
cord-289152-w5ynbewh	259	14	including	include	VBG
cord-289152-w5ynbewh	259	15	cytokines	cytokine	NNS
cord-289152-w5ynbewh	259	16	,	,	,
cord-289152-w5ynbewh	259	17	chemokines	chemokine	NNS
cord-289152-w5ynbewh	259	18	,	,	,
cord-289152-w5ynbewh	259	19	MMPs	mmp	NNS
cord-289152-w5ynbewh	259	20	,	,	,
cord-289152-w5ynbewh	259	21	and	and	CC
cord-289152-w5ynbewh	259	22	adhesion	adhesion	NN
cord-289152-w5ynbewh	259	23	molecules	molecule	NNS
cord-289152-w5ynbewh	259	24	which	which	WDT
cord-289152-w5ynbewh	259	25	often	often	RB
cord-289152-w5ynbewh	259	26	contain	contain	VBP
cord-289152-w5ynbewh	259	27	NF	nf	NN
cord-289152-w5ynbewh	259	28	-	-	HYPH
cord-289152-w5ynbewh	259	29	nB	nb	NN
cord-289152-w5ynbewh	259	30	binding	bind	VBG
cord-289152-w5ynbewh	259	31	sites	site	NNS
cord-289152-w5ynbewh	259	32	in	in	IN
cord-289152-w5ynbewh	259	33	their	-PRON-	PRP$
cord-289152-w5ynbewh	259	34	promoters	promoter	NNS
cord-289152-w5ynbewh	259	35	(	(	-LRB-
cord-289152-w5ynbewh	259	36	Caamano	Caamano	NNP
cord-289152-w5ynbewh	259	37	and	and	CC
cord-289152-w5ynbewh	259	38	Hunter	Hunter	NNP
cord-289152-w5ynbewh	259	39	,	,	,
cord-289152-w5ynbewh	259	40	2002	2002	CD
cord-289152-w5ynbewh	259	41	;	;	:
cord-289152-w5ynbewh	259	42	Kim	Kim	NNP
cord-289152-w5ynbewh	259	43	and	and	CC
cord-289152-w5ynbewh	259	44	Koh	Koh	NNP
cord-289152-w5ynbewh	259	45	,	,	,
cord-289152-w5ynbewh	259	46	2000	2000	CD
cord-289152-w5ynbewh	259	47	;	;	:
cord-289152-w5ynbewh	259	48	Li	Li	NNP
cord-289152-w5ynbewh	259	49	and	and	CC
cord-289152-w5ynbewh	259	50	Verma	Verma	NNP
cord-289152-w5ynbewh	259	51	,	,	,
cord-289152-w5ynbewh	259	52	2002	2002	CD
cord-289152-w5ynbewh	259	53	;	;	:
cord-289152-w5ynbewh	259	54	Mogensen	Mogensen	NNP
cord-289152-w5ynbewh	259	55	and	and	CC
cord-289152-w5ynbewh	259	56	Paludan	Paludan	NNP
cord-289152-w5ynbewh	259	57	,	,	,
cord-289152-w5ynbewh	259	58	2001	2001	CD
cord-289152-w5ynbewh	259	59	)	)	-RRB-
cord-289152-w5ynbewh	259	60	.	.	.
cord-289152-w5ynbewh	260	1	The	the	DT
cord-289152-w5ynbewh	260	2	MMPs	mmp	NNS
cord-289152-w5ynbewh	260	3	are	be	VBP
cord-289152-w5ynbewh	260	4	a	a	DT
cord-289152-w5ynbewh	260	5	group	group	NN
cord-289152-w5ynbewh	260	6	of	of	IN
cord-289152-w5ynbewh	260	7	zinc	zinc	NN
cord-289152-w5ynbewh	260	8	-	-	HYPH
cord-289152-w5ynbewh	260	9	and	and	CC
cord-289152-w5ynbewh	260	10	calcium	calcium	NN
cord-289152-w5ynbewh	260	11	-	-	HYPH
cord-289152-w5ynbewh	260	12	dependent	dependent	JJ
cord-289152-w5ynbewh	260	13	endopeptidases	endopeptidase	NNS
cord-289152-w5ynbewh	260	14	that	that	WDT
cord-289152-w5ynbewh	260	15	degrade	degrade	VBP
cord-289152-w5ynbewh	260	16	an	an	DT
cord-289152-w5ynbewh	260	17	extracellular	extracellular	JJ
cord-289152-w5ynbewh	260	18	matrix	matrix	NN
cord-289152-w5ynbewh	260	19	implicated	implicate	VBN
cord-289152-w5ynbewh	260	20	in	in	IN
cord-289152-w5ynbewh	260	21	tissue	tissue	NN
cord-289152-w5ynbewh	260	22	remodeling	remodeling	NN
cord-289152-w5ynbewh	260	23	and	and	CC
cord-289152-w5ynbewh	260	24	chronic	chronic	JJ
cord-289152-w5ynbewh	260	25	inflammation	inflammation	NN
cord-289152-w5ynbewh	260	26	.	.	.
cord-289152-w5ynbewh	261	1	MMPs	MMPs	NNP
cord-289152-w5ynbewh	261	2	,	,	,
cord-289152-w5ynbewh	261	3	especially	especially	RB
cord-289152-w5ynbewh	261	4	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	261	5	and	and	CC
cord-289152-w5ynbewh	261	6	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	261	7	,	,	,
cord-289152-w5ynbewh	261	8	play	play	VB
cord-289152-w5ynbewh	261	9	a	a	DT
cord-289152-w5ynbewh	261	10	role	role	NN
cord-289152-w5ynbewh	261	11	in	in	IN
cord-289152-w5ynbewh	261	12	immune	immune	JJ
cord-289152-w5ynbewh	261	13	responses	response	NNS
cord-289152-w5ynbewh	261	14	by	by	IN
cord-289152-w5ynbewh	261	15	promoting	promote	VBG
cord-289152-w5ynbewh	261	16	infiltration	infiltration	NN
cord-289152-w5ynbewh	261	17	of	of	IN
cord-289152-w5ynbewh	261	18	inflammatory	inflammatory	JJ
cord-289152-w5ynbewh	261	19	cells	cell	NNS
cord-289152-w5ynbewh	261	20	(	(	-LRB-
cord-289152-w5ynbewh	261	21	Kumagai	Kumagai	NNP
cord-289152-w5ynbewh	261	22	et	et	NNP
cord-289152-w5ynbewh	261	23	al	al	NNP
cord-289152-w5ynbewh	261	24	.	.	NNP
cord-289152-w5ynbewh	261	25	,	,	,
cord-289152-w5ynbewh	261	26	1999	1999	CD
cord-289152-w5ynbewh	261	27	)	)	-RRB-
cord-289152-w5ynbewh	261	28	.	.	.
cord-289152-w5ynbewh	262	1	A	a	DT
cord-289152-w5ynbewh	262	2	previous	previous	JJ
cord-289152-w5ynbewh	262	3	study	study	NN
cord-289152-w5ynbewh	262	4	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	262	5	that	that	IN
cord-289152-w5ynbewh	262	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	262	7	infection	infection	NN
cord-289152-w5ynbewh	262	8	significantly	significantly	RB
cord-289152-w5ynbewh	262	9	increased	increase	VBD
cord-289152-w5ynbewh	262	10	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	262	11	and	and	CC
cord-289152-w5ynbewh	262	12	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	262	13	which	which	WDT
cord-289152-w5ynbewh	262	14	correlated	correlate	VBD
cord-289152-w5ynbewh	262	15	with	with	IN
cord-289152-w5ynbewh	262	16	the	the	DT
cord-289152-w5ynbewh	262	17	appearance	appearance	NN
cord-289152-w5ynbewh	262	18	of	of	IN
cord-289152-w5ynbewh	262	19	severe	severe	JJ
cord-289152-w5ynbewh	262	20	histological	histological	JJ
cord-289152-w5ynbewh	262	21	lung	lung	NN
cord-289152-w5ynbewh	262	22	lesions	lesion	NNS
cord-289152-w5ynbewh	262	23	characterized	characterize	VBN
cord-289152-w5ynbewh	262	24	by	by	IN
cord-289152-w5ynbewh	262	25	massive	massive	JJ
cord-289152-w5ynbewh	262	26	lymphomononuclear	lymphomononuclear	NN
cord-289152-w5ynbewh	262	27	cell	cell	NN
cord-289152-w5ynbewh	262	28	infiltration	infiltration	NN
cord-289152-w5ynbewh	262	29	and	and	CC
cord-289152-w5ynbewh	262	30	possible	possible	JJ
cord-289152-w5ynbewh	262	31	local	local	JJ
cord-289152-w5ynbewh	262	32	immunosuppression	immunosuppression	NN
cord-289152-w5ynbewh	262	33	in	in	IN
cord-289152-w5ynbewh	262	34	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	262	35	-	-	HYPH
cord-289152-w5ynbewh	262	36	infected	infect	VBN
cord-289152-w5ynbewh	262	37	pigs	pig	NNS
cord-289152-w5ynbewh	262	38	.	.	.
cord-289152-w5ynbewh	263	1	Therefore	therefore	RB
cord-289152-w5ynbewh	263	2	,	,	,
cord-289152-w5ynbewh	263	3	it	-PRON-	PRP
cord-289152-w5ynbewh	263	4	is	be	VBZ
cord-289152-w5ynbewh	263	5	possible	possible	JJ
cord-289152-w5ynbewh	263	6	that	that	IN
cord-289152-w5ynbewh	263	7	MMPs	mmp	NNS
cord-289152-w5ynbewh	263	8	produced	produce	VBN
cord-289152-w5ynbewh	263	9	in	in	IN
cord-289152-w5ynbewh	263	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	263	11	-	-	HYPH
cord-289152-w5ynbewh	263	12	infected	infect	VBN
cord-289152-w5ynbewh	263	13	cells	cell	NNS
cord-289152-w5ynbewh	263	14	by	by	IN
cord-289152-w5ynbewh	263	15	NF	nf	NN
cord-289152-w5ynbewh	263	16	-	-	HYPH
cord-289152-w5ynbewh	263	17	nB	nB	NNP
cord-289152-w5ynbewh	263	18	activation	activation	NN
cord-289152-w5ynbewh	263	19	could	could	MD
cord-289152-w5ynbewh	263	20	mediate	mediate	VB
cord-289152-w5ynbewh	263	21	the	the	DT
cord-289152-w5ynbewh	263	22	influx	influx	NN
cord-289152-w5ynbewh	263	23	of	of	IN
cord-289152-w5ynbewh	263	24	new	new	JJ
cord-289152-w5ynbewh	263	25	cells	cell	NNS
cord-289152-w5ynbewh	263	26	of	of	IN
cord-289152-w5ynbewh	263	27	the	the	DT
cord-289152-w5ynbewh	263	28	monocyte	monocyte	NNP
cord-289152-w5ynbewh	263	29	/	/	SYM
cord-289152-w5ynbewh	263	30	macrophage	macrophage	NN
cord-289152-w5ynbewh	263	31	lineage	lineage	NN
cord-289152-w5ynbewh	263	32	.	.	.
cord-289152-w5ynbewh	264	1	It	-PRON-	PRP
cord-289152-w5ynbewh	264	2	is	be	VBZ
cord-289152-w5ynbewh	264	3	well	well	RB
cord-289152-w5ynbewh	264	4	established	establish	VBN
cord-289152-w5ynbewh	264	5	that	that	IN
cord-289152-w5ynbewh	264	6	NF	nf	NN
cord-289152-w5ynbewh	264	7	-	-	HYPH
cord-289152-w5ynbewh	264	8	nB	nB	NNP
cord-289152-w5ynbewh	264	9	may	may	MD
cord-289152-w5ynbewh	264	10	play	play	VB
cord-289152-w5ynbewh	264	11	a	a	DT
cord-289152-w5ynbewh	264	12	pivotal	pivotal	JJ
cord-289152-w5ynbewh	264	13	role	role	NN
cord-289152-w5ynbewh	264	14	in	in	IN
cord-289152-w5ynbewh	264	15	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	264	16	of	of	IN
cord-289152-w5ynbewh	264	17	virus	virus	NN
cord-289152-w5ynbewh	264	18	-	-	HYPH
cord-289152-w5ynbewh	264	19	infected	infect	VBN
cord-289152-w5ynbewh	264	20	cells	cell	NNS
cord-289152-w5ynbewh	264	21	.	.	.
cord-289152-w5ynbewh	265	1	The	the	DT
cord-289152-w5ynbewh	265	2	NF	nf	NN
cord-289152-w5ynbewh	265	3	-	-	HYPH
cord-289152-w5ynbewh	265	4	nB	nB	NNP
cord-289152-w5ynbewh	265	5	activation	activation	NN
cord-289152-w5ynbewh	265	6	by	by	IN
cord-289152-w5ynbewh	265	7	viruses	virus	NNS
cord-289152-w5ynbewh	265	8	could	could	MD
cord-289152-w5ynbewh	265	9	be	be	VB
cord-289152-w5ynbewh	265	10	either	either	CC
cord-289152-w5ynbewh	265	11	an	an	DT
cord-289152-w5ynbewh	265	12	anti	anti	JJ
cord-289152-w5ynbewh	265	13	-	-	JJ
cord-289152-w5ynbewh	265	14	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	265	15	response	response	NN
cord-289152-w5ynbewh	265	16	to	to	TO
cord-289152-w5ynbewh	265	17	maximize	maximize	VB
cord-289152-w5ynbewh	265	18	viral	viral	JJ
cord-289152-w5ynbewh	265	19	replication	replication	NN
cord-289152-w5ynbewh	265	20	by	by	IN
cord-289152-w5ynbewh	265	21	prolonging	prolong	VBG
cord-289152-w5ynbewh	265	22	host	host	NN
cord-289152-w5ynbewh	265	23	cell	cell	NN
cord-289152-w5ynbewh	265	24	survival	survival	NN
cord-289152-w5ynbewh	265	25	or	or	CC
cord-289152-w5ynbewh	265	26	pro	pro	JJ
cord-289152-w5ynbewh	265	27	-	-	JJ
cord-289152-w5ynbewh	265	28	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	265	29	response	response	NN
cord-289152-w5ynbewh	265	30	as	as	IN
cord-289152-w5ynbewh	265	31	a	a	DT
cord-289152-w5ynbewh	265	32	mechanism	mechanism	NN
cord-289152-w5ynbewh	265	33	to	to	TO
cord-289152-w5ynbewh	265	34	increase	increase	VB
cord-289152-w5ynbewh	265	35	virus	virus	NN
cord-289152-w5ynbewh	265	36	spread	spread	NN
cord-289152-w5ynbewh	265	37	(	(	-LRB-
cord-289152-w5ynbewh	265	38	Bowie	Bowie	NNP
cord-289152-w5ynbewh	265	39	et	et	NNP
cord-289152-w5ynbewh	265	40	al	al	NNP
cord-289152-w5ynbewh	265	41	.	.	NNP
cord-289152-w5ynbewh	265	42	,	,	,
cord-289152-w5ynbewh	265	43	2004	2004	CD
cord-289152-w5ynbewh	265	44	;	;	:
cord-289152-w5ynbewh	266	1	Mi	Mi	NNP
cord-289152-w5ynbewh	266	2	et	et	NNP
cord-289152-w5ynbewh	266	3	al	al	NNP
cord-289152-w5ynbewh	266	4	.	.	NNP
cord-289152-w5ynbewh	266	5	,	,	,
cord-289152-w5ynbewh	266	6	2001	2001	CD
cord-289152-w5ynbewh	266	7	)	)	-RRB-
cord-289152-w5ynbewh	266	8	.	.	.
cord-289152-w5ynbewh	267	1	In	in	IN
cord-289152-w5ynbewh	267	2	cells	cell	NNS
cord-289152-w5ynbewh	267	3	infected	infect	VBN
cord-289152-w5ynbewh	267	4	with	with	IN
cord-289152-w5ynbewh	267	5	viruses	virus	NNS
cord-289152-w5ynbewh	267	6	such	such	JJ
cord-289152-w5ynbewh	267	7	as	as	IN
cord-289152-w5ynbewh	267	8	Sindbis	Sindbis	NNP
cord-289152-w5ynbewh	267	9	virus	virus	NN
cord-289152-w5ynbewh	267	10	,	,	,
cord-289152-w5ynbewh	267	11	reovirus	reovirus	NNP
cord-289152-w5ynbewh	267	12	,	,	,
cord-289152-w5ynbewh	267	13	or	or	CC
cord-289152-w5ynbewh	267	14	dengue	dengue	NN
cord-289152-w5ynbewh	267	15	virus	virus	NN
cord-289152-w5ynbewh	267	16	,	,	,
cord-289152-w5ynbewh	267	17	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	267	18	is	be	VBZ
cord-289152-w5ynbewh	267	19	facilitated	facilitate	VBN
cord-289152-w5ynbewh	267	20	by	by	IN
cord-289152-w5ynbewh	267	21	the	the	DT
cord-289152-w5ynbewh	267	22	activation	activation	NN
cord-289152-w5ynbewh	267	23	of	of	IN
cord-289152-w5ynbewh	267	24	NF	nf	NN
cord-289152-w5ynbewh	267	25	-	-	HYPH
cord-289152-w5ynbewh	267	26	nB	nB	NNP
cord-289152-w5ynbewh	267	27	which	which	WDT
cord-289152-w5ynbewh	267	28	was	be	VBD
cord-289152-w5ynbewh	267	29	triggered	trigger	VBN
cord-289152-w5ynbewh	267	30	by	by	IN
cord-289152-w5ynbewh	267	31	viral	viral	JJ
cord-289152-w5ynbewh	267	32	infection	infection	NN
cord-289152-w5ynbewh	267	33	(	(	-LRB-
cord-289152-w5ynbewh	267	34	Connolly	Connolly	NNP
cord-289152-w5ynbewh	267	35	et	et	NNP
cord-289152-w5ynbewh	267	36	al	al	NNP
cord-289152-w5ynbewh	267	37	.	.	NNP
cord-289152-w5ynbewh	267	38	,	,	,
cord-289152-w5ynbewh	267	39	2000	2000	CD
cord-289152-w5ynbewh	267	40	;	;	:
cord-289152-w5ynbewh	267	41	Jan	Jan	NNP
cord-289152-w5ynbewh	267	42	et	et	NNP
cord-289152-w5ynbewh	267	43	al	al	NNP
cord-289152-w5ynbewh	267	44	.	.	NNP
cord-289152-w5ynbewh	267	45	,	,	,
cord-289152-w5ynbewh	267	46	2000	2000	CD
cord-289152-w5ynbewh	267	47	;	;	:
cord-289152-w5ynbewh	267	48	Lin	Lin	NNP
cord-289152-w5ynbewh	267	49	et	et	NNP
cord-289152-w5ynbewh	267	50	al	al	NNP
cord-289152-w5ynbewh	267	51	.	.	.
cord-289152-w5ynbewh	268	1	,	,	,
cord-289152-w5ynbewh	268	2	1995	1995	CD
cord-289152-w5ynbewh	268	3	Lin	Lin	NNP
cord-289152-w5ynbewh	268	4	et	et	NNP
cord-289152-w5ynbewh	268	5	al	al	NNP
cord-289152-w5ynbewh	268	6	.	.	NNP
cord-289152-w5ynbewh	268	7	,	,	,
cord-289152-w5ynbewh	268	8	,	,	,
cord-289152-w5ynbewh	268	9	1998	1998	CD
cord-289152-w5ynbewh	268	10	.	.	.
cord-289152-w5ynbewh	269	1	In	in	IN
cord-289152-w5ynbewh	269	2	others	other	NNS
cord-289152-w5ynbewh	269	3	,	,	,
cord-289152-w5ynbewh	269	4	activated	activate	VBN
cord-289152-w5ynbewh	269	5	NF	nf	NN
cord-289152-w5ynbewh	269	6	-	-	HYPH
cord-289152-w5ynbewh	269	7	nB	nB	NNP
cord-289152-w5ynbewh	269	8	prevents	prevent	VBZ
cord-289152-w5ynbewh	269	9	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	269	10	and	and	CC
cord-289152-w5ynbewh	269	11	prolongs	prolong	VBZ
cord-289152-w5ynbewh	269	12	cell	cell	NN
cord-289152-w5ynbewh	269	13	survival	survival	NN
cord-289152-w5ynbewh	269	14	(	(	-LRB-
cord-289152-w5ynbewh	269	15	Bowie	Bowie	NNP
cord-289152-w5ynbewh	269	16	et	et	NNP
cord-289152-w5ynbewh	269	17	al	al	NNP
cord-289152-w5ynbewh	269	18	.	.	NNP
cord-289152-w5ynbewh	269	19	,	,	,
cord-289152-w5ynbewh	269	20	2004	2004	CD
cord-289152-w5ynbewh	269	21	;	;	:
cord-289152-w5ynbewh	269	22	Goodkin	Goodkin	NNP
cord-289152-w5ynbewh	269	23	et	et	FW
cord-289152-w5ynbewh	269	24	al	al	NNP
cord-289152-w5ynbewh	269	25	.	.	NNP
cord-289152-w5ynbewh	269	26	,	,	,
cord-289152-w5ynbewh	269	27	2003	2003	CD
cord-289152-w5ynbewh	269	28	;	;	:
cord-289152-w5ynbewh	269	29	Grimm	Grimm	NNP
cord-289152-w5ynbewh	269	30	et	et	NNP
cord-289152-w5ynbewh	269	31	al	al	NNP
cord-289152-w5ynbewh	269	32	.	.	.
cord-289152-w5ynbewh	270	1	,	,	,
cord-289152-w5ynbewh	270	2	2005	2005	CD
cord-289152-w5ynbewh	270	3	;	;	:
cord-289152-w5ynbewh	270	4	Su	Su	NNP
cord-289152-w5ynbewh	270	5	et	et	FW
cord-289152-w5ynbewh	270	6	al	al	NNP
cord-289152-w5ynbewh	270	7	.	.	.
cord-289152-w5ynbewh	271	1	,	,	,
cord-289152-w5ynbewh	271	2	2001	2001	CD
cord-289152-w5ynbewh	271	3	;	;	:
cord-289152-w5ynbewh	271	4	Thomas	Thomas	NNP
cord-289152-w5ynbewh	271	5	et	et	NNP
cord-289152-w5ynbewh	271	6	al	al	NNP
cord-289152-w5ynbewh	271	7	.	.	NNP
cord-289152-w5ynbewh	271	8	,	,	,
cord-289152-w5ynbewh	271	9	2002	2002	CD
cord-289152-w5ynbewh	271	10	)	)	-RRB-
cord-289152-w5ynbewh	271	11	.	.	.
cord-289152-w5ynbewh	272	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	272	2	has	have	VBZ
cord-289152-w5ynbewh	272	3	been	be	VBN
cord-289152-w5ynbewh	272	4	known	know	VBN
cord-289152-w5ynbewh	272	5	to	to	TO
cord-289152-w5ynbewh	272	6	induce	induce	VB
cord-289152-w5ynbewh	272	7	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	272	8	mostly	mostly	RB
cord-289152-w5ynbewh	272	9	in	in	IN
cord-289152-w5ynbewh	272	10	bystander	bystander	NN
cord-289152-w5ynbewh	272	11	cells	cell	NNS
cord-289152-w5ynbewh	272	12	in	in	IN
cord-289152-w5ynbewh	272	13	vivo	vivo	NN
cord-289152-w5ynbewh	273	1	(	(	-LRB-
cord-289152-w5ynbewh	273	2	Sirinarumitr	Sirinarumitr	NNP
cord-289152-w5ynbewh	273	3	et	et	NNP
cord-289152-w5ynbewh	273	4	al	al	NNP
cord-289152-w5ynbewh	273	5	.	.	NNP
cord-289152-w5ynbewh	273	6	,	,	,
cord-289152-w5ynbewh	273	7	1998	1998	CD
cord-289152-w5ynbewh	273	8	)	)	-RRB-
cord-289152-w5ynbewh	273	9	.	.	.
cord-289152-w5ynbewh	274	1	It	-PRON-	PRP
cord-289152-w5ynbewh	274	2	is	be	VBZ
cord-289152-w5ynbewh	274	3	not	not	RB
cord-289152-w5ynbewh	274	4	known	know	VBN
cord-289152-w5ynbewh	274	5	yet	yet	RB
cord-289152-w5ynbewh	274	6	whether	whether	IN
cord-289152-w5ynbewh	274	7	the	the	DT
cord-289152-w5ynbewh	274	8	activation	activation	NN
cord-289152-w5ynbewh	274	9	of	of	IN
cord-289152-w5ynbewh	274	10	NF	nf	NN
cord-289152-w5ynbewh	274	11	-	-	HYPH
cord-289152-w5ynbewh	274	12	nB	nB	NNP
cord-289152-w5ynbewh	274	13	in	in	IN
cord-289152-w5ynbewh	274	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	274	15	infection	infection	NN
cord-289152-w5ynbewh	274	16	plays	play	VBZ
cord-289152-w5ynbewh	274	17	an	an	DT
cord-289152-w5ynbewh	274	18	anti	anti	JJ
cord-289152-w5ynbewh	274	19	-	-	JJ
cord-289152-w5ynbewh	274	20	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	274	21	role	role	NN
cord-289152-w5ynbewh	274	22	or	or	CC
cord-289152-w5ynbewh	274	23	pro	pro	JJ
cord-289152-w5ynbewh	274	24	-	-	JJ
cord-289152-w5ynbewh	274	25	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	274	26	role	role	NN
cord-289152-w5ynbewh	274	27	.	.	.
cord-289152-w5ynbewh	275	1	In	in	IN
cord-289152-w5ynbewh	275	2	summary	summary	NN
cord-289152-w5ynbewh	275	3	,	,	,
cord-289152-w5ynbewh	275	4	the	the	DT
cord-289152-w5ynbewh	275	5	present	present	JJ
cord-289152-w5ynbewh	275	6	study	study	NN
cord-289152-w5ynbewh	275	7	demonstrated	demonstrate	VBD
cord-289152-w5ynbewh	275	8	that	that	IN
cord-289152-w5ynbewh	275	9	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	275	10	activates	activate	VBZ
cord-289152-w5ynbewh	275	11	NF	NF	NNP
cord-289152-w5ynbewh	275	12	-	-	HYPH
cord-289152-w5ynbewh	275	13	nB	nb	NN
cord-289152-w5ynbewh	275	14	via	via	IN
cord-289152-w5ynbewh	275	15	InB	inb	NN
cord-289152-w5ynbewh	275	16	degradation	degradation	NN
cord-289152-w5ynbewh	275	17	in	in	IN
cord-289152-w5ynbewh	275	18	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	275	19	cells	cell	NNS
cord-289152-w5ynbewh	275	20	and	and	CC
cord-289152-w5ynbewh	275	21	PAM	PAM	NNP
cord-289152-w5ynbewh	275	22	cultures	culture	NNS
cord-289152-w5ynbewh	275	23	and	and	CC
cord-289152-w5ynbewh	275	24	that	that	IN
cord-289152-w5ynbewh	275	25	NF	nf	NN
cord-289152-w5ynbewh	275	26	-	-	HYPH
cord-289152-w5ynbewh	275	27	nB	nB	NNP
cord-289152-w5ynbewh	275	28	activation	activation	NN
cord-289152-w5ynbewh	275	29	is	be	VBZ
cord-289152-w5ynbewh	275	30	not	not	RB
cord-289152-w5ynbewh	275	31	required	require	VBN
cord-289152-w5ynbewh	275	32	for	for	IN
cord-289152-w5ynbewh	275	33	efficient	efficient	JJ
cord-289152-w5ynbewh	275	34	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	275	35	replication	replication	NN
cord-289152-w5ynbewh	275	36	in	in	IN
cord-289152-w5ynbewh	275	37	vitro	vitro	FW
cord-289152-w5ynbewh	275	38	.	.	.
cord-289152-w5ynbewh	276	1	ROS	ROS	NNP
cord-289152-w5ynbewh	276	2	induction	induction	NN
cord-289152-w5ynbewh	276	3	likely	likely	RB
cord-289152-w5ynbewh	276	4	contributes	contribute	VBZ
cord-289152-w5ynbewh	276	5	to	to	IN
cord-289152-w5ynbewh	276	6	activation	activation	NN
cord-289152-w5ynbewh	276	7	of	of	IN
cord-289152-w5ynbewh	276	8	the	the	DT
cord-289152-w5ynbewh	276	9	NF	nf	NN
cord-289152-w5ynbewh	276	10	-	-	HYPH
cord-289152-w5ynbewh	276	11	nB	nB	NNP
cord-289152-w5ynbewh	276	12	pathway	pathway	NN
cord-289152-w5ynbewh	276	13	in	in	IN
cord-289152-w5ynbewh	276	14	PRRSVinfected	prrsvinfected	JJ
cord-289152-w5ynbewh	276	15	cells	cell	NNS
cord-289152-w5ynbewh	276	16	.	.	.
cord-289152-w5ynbewh	277	1	However	however	RB
cord-289152-w5ynbewh	277	2	,	,	,
cord-289152-w5ynbewh	277	3	the	the	DT
cord-289152-w5ynbewh	277	4	detailed	detailed	JJ
cord-289152-w5ynbewh	277	5	molecular	molecular	JJ
cord-289152-w5ynbewh	277	6	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	277	7	and	and	CC
cord-289152-w5ynbewh	277	8	viral	viral	JJ
cord-289152-w5ynbewh	277	9	components	component	NNS
cord-289152-w5ynbewh	277	10	underlying	underlie	VBG
cord-289152-w5ynbewh	277	11	NF	nf	NN
cord-289152-w5ynbewh	277	12	-	-	HYPH
cord-289152-w5ynbewh	277	13	nB	nB	NNP
cord-289152-w5ynbewh	277	14	activation	activation	NN
cord-289152-w5ynbewh	277	15	remain	remain	VBP
cord-289152-w5ynbewh	277	16	to	to	TO
cord-289152-w5ynbewh	277	17	be	be	VB
cord-289152-w5ynbewh	277	18	elucidated	elucidate	VBN
cord-289152-w5ynbewh	277	19	.	.	.
cord-289152-w5ynbewh	278	1	This	this	DT
cord-289152-w5ynbewh	278	2	study	study	NN
cord-289152-w5ynbewh	278	3	also	also	RB
cord-289152-w5ynbewh	278	4	suggested	suggest	VBD
cord-289152-w5ynbewh	278	5	a	a	DT
cord-289152-w5ynbewh	278	6	possible	possible	JJ
cord-289152-w5ynbewh	278	7	role	role	NN
cord-289152-w5ynbewh	278	8	of	of	IN
cord-289152-w5ynbewh	278	9	NF	nf	NN
cord-289152-w5ynbewh	278	10	-	-	HYPH
cord-289152-w5ynbewh	278	11	nB	nB	NNP
cord-289152-w5ynbewh	278	12	activation	activation	NN
cord-289152-w5ynbewh	278	13	in	in	IN
cord-289152-w5ynbewh	278	14	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	278	15	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	278	16	by	by	IN
cord-289152-w5ynbewh	278	17	showing	show	VBG
cord-289152-w5ynbewh	278	18	that	that	IN
cord-289152-w5ynbewh	278	19	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	278	20	increased	increase	VBD
cord-289152-w5ynbewh	278	21	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	278	22	and	and	CC
cord-289152-w5ynbewh	278	23	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	278	24	mRNA	mRNA	NNP
cord-289152-w5ynbewh	278	25	expression	expression	NN
cord-289152-w5ynbewh	278	26	through	through	IN
cord-289152-w5ynbewh	278	27	the	the	DT
cord-289152-w5ynbewh	278	28	NF	nf	NN
cord-289152-w5ynbewh	278	29	-	-	HYPH
cord-289152-w5ynbewh	278	30	nB	nB	NNP
cord-289152-w5ynbewh	278	31	pathway	pathway	NN
cord-289152-w5ynbewh	278	32	.	.	.
cord-289152-w5ynbewh	279	1	Future	future	JJ
cord-289152-w5ynbewh	279	2	studies	study	NNS
cord-289152-w5ynbewh	279	3	will	will	MD
cord-289152-w5ynbewh	279	4	confirm	confirm	VB
cord-289152-w5ynbewh	279	5	if	if	IN
cord-289152-w5ynbewh	279	6	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	279	7	activates	activate	VBZ
cord-289152-w5ynbewh	279	8	the	the	DT
cord-289152-w5ynbewh	279	9	NF	nf	NN
cord-289152-w5ynbewh	279	10	-	-	HYPH
cord-289152-w5ynbewh	279	11	nB	nB	NNP
cord-289152-w5ynbewh	279	12	pathway	pathway	NN
cord-289152-w5ynbewh	279	13	in	in	IN
cord-289152-w5ynbewh	279	14	vivo	vivo	NNP
cord-289152-w5ynbewh	279	15	.	.	.
cord-289152-w5ynbewh	280	1	Understanding	understand	VBG
cord-289152-w5ynbewh	280	2	the	the	DT
cord-289152-w5ynbewh	280	3	role	role	NN
cord-289152-w5ynbewh	280	4	of	of	IN
cord-289152-w5ynbewh	280	5	NF	nf	NN
cord-289152-w5ynbewh	280	6	-	-	HYPH
cord-289152-w5ynbewh	280	7	nB	nB	NNP
cord-289152-w5ynbewh	280	8	activation	activation	NN
cord-289152-w5ynbewh	280	9	following	follow	VBG
cord-289152-w5ynbewh	280	10	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	280	11	infection	infection	NN
cord-289152-w5ynbewh	280	12	will	will	MD
cord-289152-w5ynbewh	280	13	contribute	contribute	VB
cord-289152-w5ynbewh	280	14	important	important	JJ
cord-289152-w5ynbewh	280	15	information	information	NN
cord-289152-w5ynbewh	280	16	about	about	IN
cord-289152-w5ynbewh	280	17	the	the	DT
cord-289152-w5ynbewh	280	18	molecular	molecular	JJ
cord-289152-w5ynbewh	280	19	pathogenesis	pathogenesis	NN
cord-289152-w5ynbewh	280	20	of	of	IN
cord-289152-w5ynbewh	280	21	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	280	22	infection	infection	NN
cord-289152-w5ynbewh	280	23	.	.	.
cord-289152-w5ynbewh	281	1	The	the	DT
cord-289152-w5ynbewh	281	2	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	281	3	cell	cell	NN
cord-289152-w5ynbewh	281	4	line	line	NN
cord-289152-w5ynbewh	281	5	,	,	,
cord-289152-w5ynbewh	281	6	which	which	WDT
cord-289152-w5ynbewh	281	7	is	be	VBZ
cord-289152-w5ynbewh	281	8	a	a	DT
cord-289152-w5ynbewh	281	9	clone	clone	NN
cord-289152-w5ynbewh	281	10	of	of	IN
cord-289152-w5ynbewh	281	11	the	the	DT
cord-289152-w5ynbewh	281	12	African	african	JJ
cord-289152-w5ynbewh	281	13	green	green	JJ
cord-289152-w5ynbewh	281	14	monkey	monkey	NN
cord-289152-w5ynbewh	281	15	kidney	kidney	NN
cord-289152-w5ynbewh	281	16	cell	cell	NN
cord-289152-w5ynbewh	281	17	line	line	NN
cord-289152-w5ynbewh	281	18	MA-104	ma-104	NN
cord-289152-w5ynbewh	281	19	,	,	,
cord-289152-w5ynbewh	281	20	and	and	CC
cord-289152-w5ynbewh	281	21	the	the	DT
cord-289152-w5ynbewh	281	22	HEK-293	HEK-293	NNP
cord-289152-w5ynbewh	281	23	cell	cell	NN
cord-289152-w5ynbewh	281	24	line	line	NN
cord-289152-w5ynbewh	281	25	,	,	,
cord-289152-w5ynbewh	281	26	which	which	WDT
cord-289152-w5ynbewh	281	27	is	be	VBZ
cord-289152-w5ynbewh	281	28	derived	derive	VBN
cord-289152-w5ynbewh	281	29	from	from	IN
cord-289152-w5ynbewh	281	30	human	human	JJ
cord-289152-w5ynbewh	281	31	embryonic	embryonic	JJ
cord-289152-w5ynbewh	281	32	kidney	kidney	NN
cord-289152-w5ynbewh	281	33	cells	cell	NNS
cord-289152-w5ynbewh	281	34	were	be	VBD
cord-289152-w5ynbewh	281	35	cultured	cultured	JJ
cord-289152-w5ynbewh	281	36	and	and	CC
cord-289152-w5ynbewh	281	37	maintained	maintain	VBN
cord-289152-w5ynbewh	281	38	in	in	IN
cord-289152-w5ynbewh	281	39	Dulbecco	Dulbecco	NNP
cord-289152-w5ynbewh	281	40	's	's	POS
cord-289152-w5ynbewh	281	41	Modified	modify	VBN
cord-289152-w5ynbewh	281	42	Eagle	Eagle	NNP
cord-289152-w5ynbewh	281	43	medium	medium	NN
cord-289152-w5ynbewh	281	44	(	(	-LRB-
cord-289152-w5ynbewh	281	45	DMEM	DMEM	NNP
cord-289152-w5ynbewh	281	46	)	)	-RRB-
cord-289152-w5ynbewh	281	47	supplemented	supplement	VBD
cord-289152-w5ynbewh	281	48	with	with	IN
cord-289152-w5ynbewh	281	49	10	10	CD
cord-289152-w5ynbewh	281	50	%	%	NN
cord-289152-w5ynbewh	281	51	FBS	FBS	NNP
cord-289152-w5ynbewh	281	52	,	,	,
cord-289152-w5ynbewh	281	53	0.25	0.25	CD
cord-289152-w5ynbewh	281	54	Ag	Ag	NNP
cord-289152-w5ynbewh	281	55	/	/	SYM
cord-289152-w5ynbewh	281	56	ml	ml	NN
cord-289152-w5ynbewh	281	57	fungizone	fungizone	NN
cord-289152-w5ynbewh	281	58	,	,	,
cord-289152-w5ynbewh	281	59	100	100	CD
cord-289152-w5ynbewh	281	60	U	U	NNP
cord-289152-w5ynbewh	281	61	/	/	SYM
cord-289152-w5ynbewh	281	62	ml	ml	NN
cord-289152-w5ynbewh	281	63	penicillin	penicillin	NN
cord-289152-w5ynbewh	281	64	,	,	,
cord-289152-w5ynbewh	281	65	10	10	CD
cord-289152-w5ynbewh	281	66	Ag	Ag	NNP
cord-289152-w5ynbewh	281	67	/	/	SYM
cord-289152-w5ynbewh	281	68	ml	ml	NN
cord-289152-w5ynbewh	281	69	streptomycin	streptomycin	NN
cord-289152-w5ynbewh	281	70	sulfate	sulfate	NN
cord-289152-w5ynbewh	281	71	,	,	,
cord-289152-w5ynbewh	281	72	and	and	CC
cord-289152-w5ynbewh	282	1	5	5	CD
cord-289152-w5ynbewh	282	2	Ag	Ag	NNP
cord-289152-w5ynbewh	282	3	/	/	SYM
cord-289152-w5ynbewh	282	4	ml	ml	NN
cord-289152-w5ynbewh	282	5	gentamicin	gentamicin	NNP
cord-289152-w5ynbewh	282	6	(	(	-LRB-
cord-289152-w5ynbewh	282	7	BioWhittaker	BioWhittaker	NNP
cord-289152-w5ynbewh	282	8	Inc.	Inc.	NNP
cord-289152-w5ynbewh	282	9	,	,	,
cord-289152-w5ynbewh	282	10	Walkersville	Walkersville	NNP
cord-289152-w5ynbewh	282	11	,	,	,
cord-289152-w5ynbewh	282	12	MD	MD	NNP
cord-289152-w5ynbewh	282	13	)	)	-RRB-
cord-289152-w5ynbewh	283	1	and	and	CC
cord-289152-w5ynbewh	283	2	then	then	RB
cord-289152-w5ynbewh	283	3	held	hold	VBD
cord-289152-w5ynbewh	283	4	at	at	IN
cord-289152-w5ynbewh	283	5	37	37	CD
cord-289152-w5ynbewh	283	6	-C	-C	NNS
cord-289152-w5ynbewh	283	7	in	in	IN
cord-289152-w5ynbewh	283	8	a	a	DT
cord-289152-w5ynbewh	283	9	humidified	humidify	VBN
cord-289152-w5ynbewh	283	10	5	5	CD
cord-289152-w5ynbewh	283	11	%	%	NN
cord-289152-w5ynbewh	283	12	CO	co	NN
cord-289152-w5ynbewh	283	13	2	2	CD
cord-289152-w5ynbewh	283	14	incubator	incubator	NN
cord-289152-w5ynbewh	283	15	.	.	.
cord-289152-w5ynbewh	284	1	The	the	DT
cord-289152-w5ynbewh	284	2	PAM	PAM	NNP
cord-289152-w5ynbewh	284	3	cultures	culture	NNS
cord-289152-w5ynbewh	284	4	were	be	VBD
cord-289152-w5ynbewh	284	5	obtained	obtain	VBN
cord-289152-w5ynbewh	284	6	by	by	IN
cord-289152-w5ynbewh	284	7	bronchoalveolar	bronchoalveolar	NNP
cord-289152-w5ynbewh	284	8	lavage	lavage	NN
cord-289152-w5ynbewh	284	9	of	of	IN
cord-289152-w5ynbewh	284	10	2-to	2-to	CD
cord-289152-w5ynbewh	284	11	3-week	3-week	JJ
cord-289152-w5ynbewh	284	12	-	-	HYPH
cord-289152-w5ynbewh	284	13	old	old	JJ
cord-289152-w5ynbewh	284	14	domestic	domestic	JJ
cord-289152-w5ynbewh	284	15	piglets	piglet	NNS
cord-289152-w5ynbewh	284	16	from	from	IN
cord-289152-w5ynbewh	284	17	a	a	DT
cord-289152-w5ynbewh	284	18	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	284	19	negative	negative	JJ
cord-289152-w5ynbewh	284	20	herd	herd	NN
cord-289152-w5ynbewh	284	21	.	.	.
cord-289152-w5ynbewh	285	1	The	the	DT
cord-289152-w5ynbewh	285	2	lungs	lung	NNS
cord-289152-w5ynbewh	285	3	were	be	VBD
cord-289152-w5ynbewh	285	4	removed	remove	VBN
cord-289152-w5ynbewh	285	5	from	from	IN
cord-289152-w5ynbewh	285	6	the	the	DT
cord-289152-w5ynbewh	285	7	piglets	piglet	NNS
cord-289152-w5ynbewh	285	8	immediately	immediately	RB
cord-289152-w5ynbewh	285	9	after	after	IN
cord-289152-w5ynbewh	285	10	euthanizing	euthanize	VBG
cord-289152-w5ynbewh	285	11	by	by	IN
cord-289152-w5ynbewh	285	12	electrocution	electrocution	NN
cord-289152-w5ynbewh	285	13	,	,	,
cord-289152-w5ynbewh	285	14	and	and	CC
cord-289152-w5ynbewh	285	15	RPMI-1640	rpmi-1640	NN
cord-289152-w5ynbewh	285	16	medium	medium	NN
cord-289152-w5ynbewh	285	17	(	(	-LRB-
cord-289152-w5ynbewh	286	1	Life	Life	NNP
cord-289152-w5ynbewh	286	2	Technologies	Technologies	NNPS
cord-289152-w5ynbewh	286	3	,	,	,
cord-289152-w5ynbewh	286	4	Grand	Grand	NNP
cord-289152-w5ynbewh	286	5	Island	Island	NNP
cord-289152-w5ynbewh	286	6	,	,	,
cord-289152-w5ynbewh	286	7	NY	NY	NNP
cord-289152-w5ynbewh	286	8	)	)	-RRB-
cord-289152-w5ynbewh	286	9	was	be	VBD
cord-289152-w5ynbewh	286	10	introduced	introduce	VBN
cord-289152-w5ynbewh	286	11	through	through	IN
cord-289152-w5ynbewh	286	12	the	the	DT
cord-289152-w5ynbewh	286	13	main	main	JJ
cord-289152-w5ynbewh	286	14	stem	stem	NN
cord-289152-w5ynbewh	286	15	bronchi	bronchi	NN
cord-289152-w5ynbewh	286	16	.	.	.
cord-289152-w5ynbewh	287	1	Bronchoalveolar	Bronchoalveolar	NNP
cord-289152-w5ynbewh	287	2	lavage	lavage	NN
cord-289152-w5ynbewh	287	3	fluid	fluid	NN
cord-289152-w5ynbewh	287	4	was	be	VBD
cord-289152-w5ynbewh	287	5	centrifuged	centrifuge	VBN
cord-289152-w5ynbewh	287	6	at	at	IN
cord-289152-w5ynbewh	287	7	400	400	CD
cord-289152-w5ynbewh	287	8	Â	â	NN
cord-289152-w5ynbewh	287	9	g	g	NN
cord-289152-w5ynbewh	287	10	for	for	IN
cord-289152-w5ynbewh	287	11	7	7	CD
cord-289152-w5ynbewh	287	12	min	min	NN
cord-289152-w5ynbewh	287	13	.	.	.
cord-289152-w5ynbewh	288	1	After	after	IN
cord-289152-w5ynbewh	288	2	centrifugation	centrifugation	NN
cord-289152-w5ynbewh	288	3	,	,	,
cord-289152-w5ynbewh	288	4	cell	cell	NN
cord-289152-w5ynbewh	288	5	pellets	pellet	NNS
cord-289152-w5ynbewh	288	6	were	be	VBD
cord-289152-w5ynbewh	288	7	resuspended	resuspend	VBN
cord-289152-w5ynbewh	288	8	in	in	IN
cord-289152-w5ynbewh	288	9	RPMI-1640	RPMI-1640	NNP
cord-289152-w5ynbewh	288	10	medium	medium	NN
cord-289152-w5ynbewh	288	11	supplemented	supplement	VBN
cord-289152-w5ynbewh	288	12	with	with	IN
cord-289152-w5ynbewh	288	13	10	10	CD
cord-289152-w5ynbewh	288	14	%	%	NN
cord-289152-w5ynbewh	288	15	fetal	fetal	JJ
cord-289152-w5ynbewh	288	16	bovine	bovine	JJ
cord-289152-w5ynbewh	288	17	serum	serum	NN
cord-289152-w5ynbewh	288	18	(	(	-LRB-
cord-289152-w5ynbewh	288	19	FBS	FBS	NNP
cord-289152-w5ynbewh	288	20	)	)	-RRB-
cord-289152-w5ynbewh	288	21	,	,	,
cord-289152-w5ynbewh	288	22	2	2	CD
cord-289152-w5ynbewh	288	23	mM	mm	CD
cord-289152-w5ynbewh	288	24	l	l	NN
cord-289152-w5ynbewh	288	25	-	-	HYPH
cord-289152-w5ynbewh	288	26	glutamine	glutamine	NN
cord-289152-w5ynbewh	288	27	,	,	,
cord-289152-w5ynbewh	288	28	0.25	0.25	CD
cord-289152-w5ynbewh	288	29	Ag	Ag	NNP
cord-289152-w5ynbewh	288	30	/	/	SYM
cord-289152-w5ynbewh	288	31	ml	ml	NN
cord-289152-w5ynbewh	288	32	fungizone	fungizone	NN
cord-289152-w5ynbewh	288	33	,	,	,
cord-289152-w5ynbewh	288	34	100	100	CD
cord-289152-w5ynbewh	288	35	U	U	NNP
cord-289152-w5ynbewh	288	36	/	/	SYM
cord-289152-w5ynbewh	288	37	ml	ml	NN
cord-289152-w5ynbewh	288	38	penicillin	penicillin	NN
cord-289152-w5ynbewh	288	39	,	,	,
cord-289152-w5ynbewh	288	40	10	10	CD
cord-289152-w5ynbewh	288	41	Ag	Ag	NNP
cord-289152-w5ynbewh	288	42	/	/	SYM
cord-289152-w5ynbewh	288	43	ml	ml	NN
cord-289152-w5ynbewh	288	44	streptomycin	streptomycin	NN
cord-289152-w5ynbewh	288	45	sulfate	sulfate	NN
cord-289152-w5ynbewh	288	46	,	,	,
cord-289152-w5ynbewh	288	47	and	and	CC
cord-289152-w5ynbewh	289	1	5	5	CD
cord-289152-w5ynbewh	289	2	Ag	Ag	NNP
cord-289152-w5ynbewh	289	3	/	/	SYM
cord-289152-w5ynbewh	289	4	ml	ml	NN
cord-289152-w5ynbewh	289	5	gentamicin	gentamicin	NNP
cord-289152-w5ynbewh	289	6	(	(	-LRB-
cord-289152-w5ynbewh	289	7	BioWhittaker	BioWhittaker	NNP
cord-289152-w5ynbewh	289	8	,	,	,
cord-289152-w5ynbewh	289	9	Walkersville	Walkersville	NNP
cord-289152-w5ynbewh	289	10	,	,	,
cord-289152-w5ynbewh	289	11	MD	MD	NNP
cord-289152-w5ynbewh	289	12	)	)	-RRB-
cord-289152-w5ynbewh	289	13	and	and	CC
cord-289152-w5ynbewh	289	14	plated	plate	VBD
cord-289152-w5ynbewh	289	15	at	at	IN
cord-289152-w5ynbewh	289	16	a	a	DT
cord-289152-w5ynbewh	289	17	density	density	NN
cord-289152-w5ynbewh	289	18	of	of	IN
cord-289152-w5ynbewh	289	19	2	2	CD
cord-289152-w5ynbewh	289	20	-4	-4	CD
cord-289152-w5ynbewh	289	21	Â	â	CD
cord-289152-w5ynbewh	289	22	10	10	CD
cord-289152-w5ynbewh	289	23	5	5	CD
cord-289152-w5ynbewh	289	24	cells	cell	NNS
cord-289152-w5ynbewh	289	25	/	/	SYM
cord-289152-w5ynbewh	289	26	well	well	RB
cord-289152-w5ynbewh	289	27	in	in	IN
cord-289152-w5ynbewh	289	28	a	a	DT
cord-289152-w5ynbewh	289	29	24-well	24-well	CD
cord-289152-w5ynbewh	289	30	Primaria	Primaria	NNP
cord-289152-w5ynbewh	289	31	plate	plate	NN
cord-289152-w5ynbewh	289	32	(	(	-LRB-
cord-289152-w5ynbewh	289	33	Becton	Becton	NNP
cord-289152-w5ynbewh	289	34	Dickinson	Dickinson	NNP
cord-289152-w5ynbewh	289	35	and	and	CC
cord-289152-w5ynbewh	289	36	Company	Company	NNP
cord-289152-w5ynbewh	289	37	,	,	,
cord-289152-w5ynbewh	289	38	Franklin	Franklin	NNP
cord-289152-w5ynbewh	289	39	Lakes	Lakes	NNP
cord-289152-w5ynbewh	289	40	,	,	,
cord-289152-w5ynbewh	289	41	NJ	NJ	NNP
cord-289152-w5ynbewh	289	42	)	)	-RRB-
cord-289152-w5ynbewh	289	43	.	.	.
cord-289152-w5ynbewh	290	1	The	the	DT
cord-289152-w5ynbewh	290	2	PAM	PAM	NNP
cord-289152-w5ynbewh	290	3	cultures	culture	NNS
cord-289152-w5ynbewh	290	4	were	be	VBD
cord-289152-w5ynbewh	290	5	confirmed	confirm	VBN
cord-289152-w5ynbewh	290	6	to	to	TO
cord-289152-w5ynbewh	290	7	be	be	VB
cord-289152-w5ynbewh	290	8	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	290	9	-	-	HYPH
cord-289152-w5ynbewh	290	10	negative	negative	JJ
cord-289152-w5ynbewh	290	11	by	by	IN
cord-289152-w5ynbewh	290	12	RT	RT	NNP
cord-289152-w5ynbewh	290	13	-	-	HYPH
cord-289152-w5ynbewh	290	14	PCR	PCR	NNP
cord-289152-w5ynbewh	290	15	before	before	IN
cord-289152-w5ynbewh	290	16	used	use	VBN
cord-289152-w5ynbewh	290	17	in	in	IN
cord-289152-w5ynbewh	290	18	subsequent	subsequent	JJ
cord-289152-w5ynbewh	290	19	experiments	experiment	NNS
cord-289152-w5ynbewh	290	20	.	.	.
cord-289152-w5ynbewh	291	1	PAM	PAM	NNP
cord-289152-w5ynbewh	291	2	cultures	culture	NNS
cord-289152-w5ynbewh	291	3	were	be	VBD
cord-289152-w5ynbewh	291	4	incubated	incubate	VBN
cord-289152-w5ynbewh	291	5	for	for	IN
cord-289152-w5ynbewh	291	6	24	24	CD
cord-289152-w5ynbewh	291	7	h	h	NN
cord-289152-w5ynbewh	291	8	at	at	IN
cord-289152-w5ynbewh	291	9	37	37	CD
cord-289152-w5ynbewh	291	10	-C	-C	NNS
cord-289152-w5ynbewh	291	11	in	in	IN
cord-289152-w5ynbewh	291	12	a	a	DT
cord-289152-w5ynbewh	291	13	humidified	humidify	VBN
cord-289152-w5ynbewh	291	14	5	5	CD
cord-289152-w5ynbewh	291	15	%	%	NN
cord-289152-w5ynbewh	291	16	CO	co	NN
cord-289152-w5ynbewh	291	17	2	2	CD
cord-289152-w5ynbewh	291	18	incubator	incubator	NN
cord-289152-w5ynbewh	291	19	and	and	CC
cord-289152-w5ynbewh	291	20	washed	wash	VBD
cord-289152-w5ynbewh	291	21	once	once	RB
cord-289152-w5ynbewh	291	22	with	with	IN
cord-289152-w5ynbewh	291	23	complete	complete	JJ
cord-289152-w5ynbewh	291	24	RPMI-1640	rpmi-1640	NN
cord-289152-w5ynbewh	291	25	media	medium	NNS
cord-289152-w5ynbewh	291	26	before	before	IN
cord-289152-w5ynbewh	291	27	use	use	NN
cord-289152-w5ynbewh	291	28	.	.	.
cord-289152-w5ynbewh	292	1	All	all	DT
cord-289152-w5ynbewh	292	2	cells	cell	NNS
cord-289152-w5ynbewh	292	3	were	be	VBD
cord-289152-w5ynbewh	292	4	maintained	maintain	VBN
cord-289152-w5ynbewh	292	5	at	at	IN
cord-289152-w5ynbewh	292	6	37	37	CD
cord-289152-w5ynbewh	292	7	-C	-C	NNS
cord-289152-w5ynbewh	292	8	in	in	IN
cord-289152-w5ynbewh	292	9	a	a	DT
cord-289152-w5ynbewh	292	10	humidified	humidify	VBN
cord-289152-w5ynbewh	292	11	5	5	CD
cord-289152-w5ynbewh	292	12	%	%	NN
cord-289152-w5ynbewh	292	13	CO	co	NN
cord-289152-w5ynbewh	292	14	2	2	CD
cord-289152-w5ynbewh	292	15	incubator	incubator	NN
cord-289152-w5ynbewh	292	16	.	.	.
cord-289152-w5ynbewh	293	1	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	293	2	isolate	isolate	VBP
cord-289152-w5ynbewh	293	3	25544	25544	CD
cord-289152-w5ynbewh	293	4	was	be	VBD
cord-289152-w5ynbewh	293	5	obtained	obtain	VBN
cord-289152-w5ynbewh	293	6	from	from	IN
cord-289152-w5ynbewh	293	7	clinical	clinical	JJ
cord-289152-w5ynbewh	293	8	cases	case	NNS
cord-289152-w5ynbewh	293	9	submitted	submit	VBN
cord-289152-w5ynbewh	293	10	to	to	IN
cord-289152-w5ynbewh	293	11	the	the	DT
cord-289152-w5ynbewh	293	12	University	University	NNP
cord-289152-w5ynbewh	293	13	of	of	IN
cord-289152-w5ynbewh	293	14	Missouri	Missouri	NNP
cord-289152-w5ynbewh	293	15	's	's	POS
cord-289152-w5ynbewh	293	16	Veterinary	Veterinary	NNP
cord-289152-w5ynbewh	293	17	Medicine	Medicine	NNP
cord-289152-w5ynbewh	293	18	Diagnostic	Diagnostic	NNP
cord-289152-w5ynbewh	293	19	Laboratory	Laboratory	NNP
cord-289152-w5ynbewh	293	20	.	.	.
cord-289152-w5ynbewh	294	1	Virus	virus	NN
cord-289152-w5ynbewh	294	2	stocks	stock	NNS
cord-289152-w5ynbewh	294	3	of	of	IN
cord-289152-w5ynbewh	294	4	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	294	5	were	be	VBD
cord-289152-w5ynbewh	294	6	prepared	prepare	VBN
cord-289152-w5ynbewh	294	7	in	in	IN
cord-289152-w5ynbewh	294	8	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	294	9	cells	cell	NNS
cord-289152-w5ynbewh	294	10	.	.	.
cord-289152-w5ynbewh	295	1	A	a	DT
cord-289152-w5ynbewh	295	2	low	low	JJ
cord-289152-w5ynbewh	295	3	multiplicity	multiplicity	NN
cord-289152-w5ynbewh	295	4	of	of	IN
cord-289152-w5ynbewh	295	5	infection	infection	NN
cord-289152-w5ynbewh	295	6	(	(	-LRB-
cord-289152-w5ynbewh	295	7	MOI	MOI	NNP
cord-289152-w5ynbewh	295	8	<	<	XX
cord-289152-w5ynbewh	295	9	0.05	0.05	CD
cord-289152-w5ynbewh	295	10	)	)	-RRB-
cord-289152-w5ynbewh	295	11	was	be	VBD
cord-289152-w5ynbewh	295	12	used	use	VBN
cord-289152-w5ynbewh	295	13	to	to	TO
cord-289152-w5ynbewh	295	14	prepare	prepare	VB
cord-289152-w5ynbewh	295	15	viral	viral	JJ
cord-289152-w5ynbewh	295	16	stocks	stock	NNS
cord-289152-w5ynbewh	295	17	.	.	.
cord-289152-w5ynbewh	296	1	For	for	IN
cord-289152-w5ynbewh	296	2	virus	virus	NN
cord-289152-w5ynbewh	296	3	infection	infection	NN
cord-289152-w5ynbewh	296	4	,	,	,
cord-289152-w5ynbewh	296	5	cells	cell	NNS
cord-289152-w5ynbewh	296	6	were	be	VBD
cord-289152-w5ynbewh	296	7	initially	initially	RB
cord-289152-w5ynbewh	296	8	adsorbed	adsorb	VBN
cord-289152-w5ynbewh	296	9	with	with	IN
cord-289152-w5ynbewh	296	10	virus	virus	NN
cord-289152-w5ynbewh	296	11	at	at	IN
cord-289152-w5ynbewh	296	12	the	the	DT
cord-289152-w5ynbewh	296	13	indicated	indicate	VBN
cord-289152-w5ynbewh	296	14	MOI	MOI	NNP
cord-289152-w5ynbewh	296	15	for	for	IN
cord-289152-w5ynbewh	296	16	1	1	CD
cord-289152-w5ynbewh	296	17	h	h	NN
cord-289152-w5ynbewh	296	18	at	at	IN
cord-289152-w5ynbewh	296	19	37	37	CD
cord-289152-w5ynbewh	296	20	-C.	-c.	NN
cord-289152-w5ynbewh	297	1	After	after	IN
cord-289152-w5ynbewh	297	2	1	1	CD
cord-289152-w5ynbewh	297	3	h	h	NN
cord-289152-w5ynbewh	297	4	of	of	IN
cord-289152-w5ynbewh	297	5	adsorption	adsorption	NN
cord-289152-w5ynbewh	297	6	,	,	,
cord-289152-w5ynbewh	297	7	cells	cell	NNS
cord-289152-w5ynbewh	297	8	were	be	VBD
cord-289152-w5ynbewh	297	9	gently	gently	RB
cord-289152-w5ynbewh	297	10	washed	wash	VBN
cord-289152-w5ynbewh	297	11	with	with	IN
cord-289152-w5ynbewh	297	12	medium	medium	NN
cord-289152-w5ynbewh	297	13	.	.	.
cord-289152-w5ynbewh	298	1	At	at	IN
cord-289152-w5ynbewh	298	2	indicated	indicate	VBN
cord-289152-w5ynbewh	298	3	time	time	NN
cord-289152-w5ynbewh	298	4	points	point	NNS
cord-289152-w5ynbewh	298	5	post	post	NN
cord-289152-w5ynbewh	298	6	-	-	NN
cord-289152-w5ynbewh	298	7	infection	infection	JJ
cord-289152-w5ynbewh	298	8	(	(	-LRB-
cord-289152-w5ynbewh	298	9	p.i	p.i	NNP
cord-289152-w5ynbewh	298	10	.	.	NNP
cord-289152-w5ynbewh	298	11	)	)	-RRB-
cord-289152-w5ynbewh	298	12	,	,	,
cord-289152-w5ynbewh	298	13	culture	culture	NN
cord-289152-w5ynbewh	298	14	media	medium	NNS
cord-289152-w5ynbewh	298	15	were	be	VBD
cord-289152-w5ynbewh	298	16	harvested	harvest	VBN
cord-289152-w5ynbewh	298	17	for	for	IN
cord-289152-w5ynbewh	298	18	the	the	DT
cord-289152-w5ynbewh	298	19	virus	virus	NN
cord-289152-w5ynbewh	298	20	titration	titration	NN
cord-289152-w5ynbewh	298	21	,	,	,
cord-289152-w5ynbewh	298	22	and	and	CC
cord-289152-w5ynbewh	298	23	cells	cell	NNS
cord-289152-w5ynbewh	298	24	were	be	VBD
cord-289152-w5ynbewh	298	25	lysed	lyse	VBN
cord-289152-w5ynbewh	298	26	to	to	TO
cord-289152-w5ynbewh	298	27	prepare	prepare	VB
cord-289152-w5ynbewh	298	28	cellular	cellular	JJ
cord-289152-w5ynbewh	298	29	extracts	extract	NNS
cord-289152-w5ynbewh	298	30	.	.	.
cord-289152-w5ynbewh	299	1	Adenovirus	Adenovirus	NNP
cord-289152-w5ynbewh	299	2	vectors	vector	NNS
cord-289152-w5ynbewh	299	3	expressing	express	VBG
cord-289152-w5ynbewh	299	4	a	a	DT
cord-289152-w5ynbewh	299	5	dominant	dominant	JJ
cord-289152-w5ynbewh	299	6	negative	negative	JJ
cord-289152-w5ynbewh	299	7	InBa	InBa	NNS
cord-289152-w5ynbewh	299	8	or	or	CC
cord-289152-w5ynbewh	299	9	green	green	JJ
cord-289152-w5ynbewh	299	10	fluorescent	fluorescent	NN
cord-289152-w5ynbewh	299	11	protein	protein	NN
cord-289152-w5ynbewh	299	12	(	(	-LRB-
cord-289152-w5ynbewh	299	13	GFP	GFP	NNP
cord-289152-w5ynbewh	299	14	)	)	-RRB-
cord-289152-w5ynbewh	299	15	were	be	VBD
cord-289152-w5ynbewh	299	16	kind	kind	JJ
cord-289152-w5ynbewh	299	17	gifts	gift	NNS
cord-289152-w5ynbewh	299	18	from	from	IN
cord-289152-w5ynbewh	299	19	Dr.	Dr.	NNP
cord-289152-w5ynbewh	299	20	Steven	Steven	NNP
cord-289152-w5ynbewh	299	21	L.	L.	NNP
cord-289152-w5ynbewh	299	22	Bachenheimer	Bachenheimer	NNP
cord-289152-w5ynbewh	299	23	(	(	-LRB-
cord-289152-w5ynbewh	299	24	University	University	NNP
cord-289152-w5ynbewh	299	25	of	of	IN
cord-289152-w5ynbewh	299	26	North	North	NNP
cord-289152-w5ynbewh	299	27	Carolina	Carolina	NNP
cord-289152-w5ynbewh	299	28	,	,	,
cord-289152-w5ynbewh	299	29	USA	USA	NNP
cord-289152-w5ynbewh	299	30	)	)	-RRB-
cord-289152-w5ynbewh	299	31	.	.	.
cord-289152-w5ynbewh	300	1	Adenovirus	Adenovirus	NNP
cord-289152-w5ynbewh	300	2	stocks	stock	NNS
cord-289152-w5ynbewh	300	3	were	be	VBD
cord-289152-w5ynbewh	300	4	prepared	prepare	VBN
cord-289152-w5ynbewh	300	5	in	in	IN
cord-289152-w5ynbewh	300	6	HEK-293	HEK-293	NNP
cord-289152-w5ynbewh	300	7	cells	cell	NNS
cord-289152-w5ynbewh	300	8	.	.	.
cord-289152-w5ynbewh	301	1	Subconfluent	Subconfluent	NNP
cord-289152-w5ynbewh	301	2	monolayers	monolayer	NNS
cord-289152-w5ynbewh	301	3	of	of	IN
cord-289152-w5ynbewh	301	4	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	301	5	cells	cell	NNS
cord-289152-w5ynbewh	301	6	in	in	IN
cord-289152-w5ynbewh	301	7	a	a	DT
cord-289152-w5ynbewh	301	8	24well	24well	CD
cord-289152-w5ynbewh	301	9	plate	plate	NN
cord-289152-w5ynbewh	301	10	were	be	VBD
cord-289152-w5ynbewh	301	11	transfected	transfecte	VBN
cord-289152-w5ynbewh	301	12	with	with	IN
cord-289152-w5ynbewh	301	13	10	10	CD
cord-289152-w5ynbewh	301	14	ng	ng	NN
cord-289152-w5ynbewh	301	15	of	of	IN
cord-289152-w5ynbewh	301	16	pRL	pRL	NNP
cord-289152-w5ynbewh	301	17	-	-	HYPH
cord-289152-w5ynbewh	301	18	TK	TK	NNP
cord-289152-w5ynbewh	301	19	(	(	-LRB-
cord-289152-w5ynbewh	301	20	Promega	Promega	NNP
cord-289152-w5ynbewh	301	21	,	,	,
cord-289152-w5ynbewh	301	22	Madison	Madison	NNP
cord-289152-w5ynbewh	301	23	,	,	,
cord-289152-w5ynbewh	301	24	WI	WI	NNP
cord-289152-w5ynbewh	301	25	)	)	-RRB-
cord-289152-w5ynbewh	301	26	and	and	CC
cord-289152-w5ynbewh	301	27	100	100	CD
cord-289152-w5ynbewh	301	28	ng	ng	NN
cord-289152-w5ynbewh	301	29	of	of	IN
cord-289152-w5ynbewh	301	30	pNF	pNF	NNP
cord-289152-w5ynbewh	301	31	-	-	HYPH
cord-289152-w5ynbewh	301	32	nBluc	nBluc	NNP
cord-289152-w5ynbewh	301	33	(	(	-LRB-
cord-289152-w5ynbewh	301	34	Stratagene	Stratagene	NNP
cord-289152-w5ynbewh	301	35	,	,	,
cord-289152-w5ynbewh	301	36	La	La	NNP
cord-289152-w5ynbewh	301	37	Jolla	Jolla	NNP
cord-289152-w5ynbewh	301	38	,	,	,
cord-289152-w5ynbewh	301	39	CA	CA	NNP
cord-289152-w5ynbewh	301	40	)	)	-RRB-
cord-289152-w5ynbewh	301	41	using	use	VBG
cord-289152-w5ynbewh	301	42	the	the	DT
cord-289152-w5ynbewh	301	43	Lipofectamine	Lipofectamine	NNP
cord-289152-w5ynbewh	301	44	transfection	transfection	NN
cord-289152-w5ynbewh	301	45	reagent	reagent	NN
cord-289152-w5ynbewh	301	46	(	(	-LRB-
cord-289152-w5ynbewh	301	47	Invitrogen	Invitrogen	NNP
cord-289152-w5ynbewh	301	48	Carlsbad	Carlsbad	NNP
cord-289152-w5ynbewh	301	49	,	,	,
cord-289152-w5ynbewh	301	50	CA	CA	NNP
cord-289152-w5ynbewh	301	51	)	)	-RRB-
cord-289152-w5ynbewh	301	52	.	.	.
cord-289152-w5ynbewh	302	1	The	the	DT
cord-289152-w5ynbewh	302	2	pRL	prl	NN
cord-289152-w5ynbewh	302	3	-	-	HYPH
cord-289152-w5ynbewh	302	4	TK	tk	NN
cord-289152-w5ynbewh	302	5	plasmid	plasmid	NN
cord-289152-w5ynbewh	302	6	contains	contain	VBZ
cord-289152-w5ynbewh	302	7	the	the	DT
cord-289152-w5ynbewh	302	8	Renilla	Renilla	NNP
cord-289152-w5ynbewh	302	9	reniformis	reniformis	NNP
cord-289152-w5ynbewh	302	10	(	(	-LRB-
cord-289152-w5ynbewh	302	11	sea	sea	NN
cord-289152-w5ynbewh	302	12	pansy	pansy	NN
cord-289152-w5ynbewh	302	13	)	)	-RRB-
cord-289152-w5ynbewh	302	14	luciferase	luciferase	NN
cord-289152-w5ynbewh	302	15	gene	gene	NN
cord-289152-w5ynbewh	302	16	under	under	IN
cord-289152-w5ynbewh	302	17	the	the	DT
cord-289152-w5ynbewh	302	18	transcriptional	transcriptional	JJ
cord-289152-w5ynbewh	302	19	control	control	NN
cord-289152-w5ynbewh	302	20	of	of	IN
cord-289152-w5ynbewh	302	21	the	the	DT
cord-289152-w5ynbewh	302	22	herpesvirus	herpesvirus	NN
cord-289152-w5ynbewh	302	23	thymidine	thymidine	NN
cord-289152-w5ynbewh	302	24	kinase	kinase	NN
cord-289152-w5ynbewh	302	25	promoter	promoter	NN
cord-289152-w5ynbewh	302	26	and	and	CC
cord-289152-w5ynbewh	302	27	constitutively	constitutively	RB
cord-289152-w5ynbewh	302	28	expresses	express	VBZ
cord-289152-w5ynbewh	302	29	low	low	JJ
cord-289152-w5ynbewh	302	30	levels	level	NNS
cord-289152-w5ynbewh	302	31	of	of	IN
cord-289152-w5ynbewh	302	32	renillar	renillar	JJ
cord-289152-w5ynbewh	302	33	luciferase	luciferase	NN
cord-289152-w5ynbewh	302	34	.	.	.
cord-289152-w5ynbewh	303	1	The	the	DT
cord-289152-w5ynbewh	303	2	pNF	pNF	NNP
cord-289152-w5ynbewh	303	3	-	-	HYPH
cord-289152-w5ynbewh	303	4	nBluc	nBluc	NNP
cord-289152-w5ynbewh	303	5	plasmid	plasmid	NN
cord-289152-w5ynbewh	303	6	contains	contain	VBZ
cord-289152-w5ynbewh	303	7	the	the	DT
cord-289152-w5ynbewh	303	8	firefly	firefly	NN
cord-289152-w5ynbewh	303	9	luciferase	luciferase	NN
cord-289152-w5ynbewh	303	10	gene	gene	NN
cord-289152-w5ynbewh	303	11	under	under	IN
cord-289152-w5ynbewh	303	12	the	the	DT
cord-289152-w5ynbewh	303	13	transcriptional	transcriptional	JJ
cord-289152-w5ynbewh	303	14	control	control	NN
cord-289152-w5ynbewh	303	15	of	of	IN
cord-289152-w5ynbewh	303	16	a	a	DT
cord-289152-w5ynbewh	303	17	synthetic	synthetic	JJ
cord-289152-w5ynbewh	303	18	promoter	promoter	NN
cord-289152-w5ynbewh	303	19	containing	contain	VBG
cord-289152-w5ynbewh	303	20	five	five	CD
cord-289152-w5ynbewh	303	21	direct	direct	JJ
cord-289152-w5ynbewh	303	22	repeats	repeat	NNS
cord-289152-w5ynbewh	303	23	of	of	IN
cord-289152-w5ynbewh	303	24	the	the	DT
cord-289152-w5ynbewh	303	25	NF	nf	NN
cord-289152-w5ynbewh	303	26	-	-	HYPH
cord-289152-w5ynbewh	303	27	nB	nb	NN
cord-289152-w5ynbewh	303	28	binding	bind	VBG
cord-289152-w5ynbewh	303	29	element	element	NN
cord-289152-w5ynbewh	303	30	.	.	.
cord-289152-w5ynbewh	304	1	After	after	IN
cord-289152-w5ynbewh	304	2	transfection	transfection	NN
cord-289152-w5ynbewh	304	3	,	,	,
cord-289152-w5ynbewh	304	4	cells	cell	NNS
cord-289152-w5ynbewh	304	5	were	be	VBD
cord-289152-w5ynbewh	304	6	mock	mock	JJ
cord-289152-w5ynbewh	304	7	-	-	HYPH
cord-289152-w5ynbewh	304	8	infected	infect	VBN
cord-289152-w5ynbewh	304	9	or	or	CC
cord-289152-w5ynbewh	304	10	infected	infect	VBN
cord-289152-w5ynbewh	304	11	with	with	IN
cord-289152-w5ynbewh	304	12	viruses	virus	NNS
cord-289152-w5ynbewh	304	13	at	at	IN
cord-289152-w5ynbewh	304	14	the	the	DT
cord-289152-w5ynbewh	304	15	indicated	indicate	VBN
cord-289152-w5ynbewh	304	16	MOI	MOI	NNP
cord-289152-w5ynbewh	304	17	.	.	.
cord-289152-w5ynbewh	305	1	At	at	IN
cord-289152-w5ynbewh	305	2	various	various	JJ
cord-289152-w5ynbewh	305	3	time	time	NN
cord-289152-w5ynbewh	305	4	points	point	NNS
cord-289152-w5ynbewh	305	5	post	post	NN
cord-289152-w5ynbewh	305	6	-	-	NN
cord-289152-w5ynbewh	305	7	infection	infection	NN
cord-289152-w5ynbewh	305	8	,	,	,
cord-289152-w5ynbewh	305	9	cell	cell	NN
cord-289152-w5ynbewh	305	10	monolayers	monolayer	NNS
cord-289152-w5ynbewh	305	11	were	be	VBD
cord-289152-w5ynbewh	305	12	lysed	lyse	VBN
cord-289152-w5ynbewh	305	13	in	in	IN
cord-289152-w5ynbewh	305	14	150	150	CD
cord-289152-w5ynbewh	305	15	Al	Al	NNP
cord-289152-w5ynbewh	305	16	of	of	IN
cord-289152-w5ynbewh	305	17	passive	passive	JJ
cord-289152-w5ynbewh	305	18	lysis	lysis	NN
cord-289152-w5ynbewh	305	19	buffer	buffer	NN
cord-289152-w5ynbewh	305	20	(	(	-LRB-
cord-289152-w5ynbewh	305	21	Promega	Promega	NNP
cord-289152-w5ynbewh	305	22	,	,	,
cord-289152-w5ynbewh	305	23	Madison	Madison	NNP
cord-289152-w5ynbewh	305	24	,	,	,
cord-289152-w5ynbewh	305	25	WI	WI	NNP
cord-289152-w5ynbewh	305	26	)	)	-RRB-
cord-289152-w5ynbewh	305	27	followed	follow	VBN
cord-289152-w5ynbewh	305	28	by	by	IN
cord-289152-w5ynbewh	305	29	cell	cell	NN
cord-289152-w5ynbewh	305	30	lysate	lysate	NN
cord-289152-w5ynbewh	305	31	analysis	analysis	NN
cord-289152-w5ynbewh	305	32	for	for	IN
cord-289152-w5ynbewh	305	33	both	both	CC
cord-289152-w5ynbewh	305	34	luciferase	luciferase	NN
cord-289152-w5ynbewh	305	35	activities	activity	NNS
cord-289152-w5ynbewh	305	36	by	by	IN
cord-289152-w5ynbewh	305	37	using	use	VBG
cord-289152-w5ynbewh	305	38	the	the	DT
cord-289152-w5ynbewh	305	39	Dual	Dual	NNP
cord-289152-w5ynbewh	305	40	Luciferase	Luciferase	NNP
cord-289152-w5ynbewh	305	41	Reporter	reporter	NN
cord-289152-w5ynbewh	305	42	assay	assay	NN
cord-289152-w5ynbewh	305	43	(	(	-LRB-
cord-289152-w5ynbewh	305	44	Promega	Promega	NNP
cord-289152-w5ynbewh	305	45	,	,	,
cord-289152-w5ynbewh	305	46	Madison	Madison	NNP
cord-289152-w5ynbewh	305	47	,	,	,
cord-289152-w5ynbewh	305	48	WI	WI	NNP
cord-289152-w5ynbewh	305	49	)	)	-RRB-
cord-289152-w5ynbewh	305	50	.	.	.
cord-289152-w5ynbewh	306	1	Luciferase	luciferase	NN
cord-289152-w5ynbewh	306	2	activity	activity	NN
cord-289152-w5ynbewh	306	3	was	be	VBD
cord-289152-w5ynbewh	306	4	measured	measure	VBN
cord-289152-w5ynbewh	306	5	as	as	IN
cord-289152-w5ynbewh	306	6	relative	relative	JJ
cord-289152-w5ynbewh	306	7	light	light	JJ
cord-289152-w5ynbewh	306	8	units	unit	NNS
cord-289152-w5ynbewh	306	9	(	(	-LRB-
cord-289152-w5ynbewh	306	10	RLUs	rlu	NNS
cord-289152-w5ynbewh	306	11	)	)	-RRB-
cord-289152-w5ynbewh	306	12	using	use	VBG
cord-289152-w5ynbewh	306	13	a	a	DT
cord-289152-w5ynbewh	306	14	luminometer	luminometer	NN
cord-289152-w5ynbewh	306	15	(	(	-LRB-
cord-289152-w5ynbewh	306	16	Turner	Turner	NNP
cord-289152-w5ynbewh	306	17	BioSystems	BioSystems	NNP
cord-289152-w5ynbewh	306	18	,	,	,
cord-289152-w5ynbewh	306	19	Inc.	Inc.	NNP
cord-289152-w5ynbewh	306	20	Sunnyvale	Sunnyvale	NNP
cord-289152-w5ynbewh	306	21	,	,	,
cord-289152-w5ynbewh	306	22	CA	CA	NNP
cord-289152-w5ynbewh	306	23	)	)	-RRB-
cord-289152-w5ynbewh	306	24	.	.	.
cord-289152-w5ynbewh	307	1	For	for	IN
cord-289152-w5ynbewh	307	2	all	all	DT
cord-289152-w5ynbewh	307	3	assays	assay	NNS
cord-289152-w5ynbewh	307	4	,	,	,
cord-289152-w5ynbewh	307	5	experiments	experiment	NNS
cord-289152-w5ynbewh	307	6	were	be	VBD
cord-289152-w5ynbewh	307	7	performed	perform	VBN
cord-289152-w5ynbewh	307	8	in	in	IN
cord-289152-w5ynbewh	307	9	triplicate	triplicate	NN
cord-289152-w5ynbewh	307	10	.	.	.
cord-289152-w5ynbewh	308	1	For	for	IN
cord-289152-w5ynbewh	308	2	each	each	DT
cord-289152-w5ynbewh	308	3	experimental	experimental	JJ
cord-289152-w5ynbewh	308	4	point	point	NN
cord-289152-w5ynbewh	308	5	,	,	,
cord-289152-w5ynbewh	308	6	the	the	DT
cord-289152-w5ynbewh	308	7	average	average	NN
cord-289152-w5ynbewh	308	8	of	of	IN
cord-289152-w5ynbewh	308	9	the	the	DT
cord-289152-w5ynbewh	308	10	firefly	firefly	NN
cord-289152-w5ynbewh	308	11	luciferase	luciferase	NN
cord-289152-w5ynbewh	308	12	activity	activity	NN
cord-289152-w5ynbewh	308	13	was	be	VBD
cord-289152-w5ynbewh	308	14	divided	divide	VBN
cord-289152-w5ynbewh	308	15	by	by	IN
cord-289152-w5ynbewh	308	16	the	the	DT
cord-289152-w5ynbewh	308	17	average	average	NN
cord-289152-w5ynbewh	308	18	of	of	IN
cord-289152-w5ynbewh	308	19	sea	sea	NN
cord-289152-w5ynbewh	308	20	pansy	pansy	NN
cord-289152-w5ynbewh	308	21	luciferase	luciferase	NN
cord-289152-w5ynbewh	308	22	activity	activity	NN
cord-289152-w5ynbewh	308	23	to	to	TO
cord-289152-w5ynbewh	308	24	correct	correct	VB
cord-289152-w5ynbewh	308	25	for	for	IN
cord-289152-w5ynbewh	308	26	differences	difference	NNS
cord-289152-w5ynbewh	308	27	in	in	IN
cord-289152-w5ynbewh	308	28	transfection	transfection	NN
cord-289152-w5ynbewh	308	29	efficiencies	efficiency	NNS
cord-289152-w5ynbewh	308	30	.	.	.
cord-289152-w5ynbewh	309	1	The	the	DT
cord-289152-w5ynbewh	309	2	resulting	result	VBG
cord-289152-w5ynbewh	309	3	ratios	ratio	NNS
cord-289152-w5ynbewh	309	4	were	be	VBD
cord-289152-w5ynbewh	309	5	used	use	VBN
cord-289152-w5ynbewh	309	6	to	to	TO
cord-289152-w5ynbewh	309	7	compare	compare	VB
cord-289152-w5ynbewh	309	8	the	the	DT
cord-289152-w5ynbewh	309	9	expression	expression	NN
cord-289152-w5ynbewh	309	10	of	of	IN
cord-289152-w5ynbewh	309	11	the	the	DT
cord-289152-w5ynbewh	309	12	firefly	firefly	NN
cord-289152-w5ynbewh	309	13	luciferase	luciferase	NN
cord-289152-w5ynbewh	309	14	gene	gene	NN
cord-289152-w5ynbewh	309	15	in	in	IN
cord-289152-w5ynbewh	309	16	virus	virus	NN
cord-289152-w5ynbewh	309	17	-	-	HYPH
cord-289152-w5ynbewh	309	18	infected	infect	VBN
cord-289152-w5ynbewh	309	19	cells	cell	NNS
cord-289152-w5ynbewh	309	20	to	to	IN
cord-289152-w5ynbewh	309	21	that	that	DT
cord-289152-w5ynbewh	309	22	present	present	JJ
cord-289152-w5ynbewh	309	23	in	in	IN
cord-289152-w5ynbewh	309	24	uninfected	uninfected	JJ
cord-289152-w5ynbewh	309	25	(	(	-LRB-
cord-289152-w5ynbewh	309	26	mock	mock	JJ
cord-289152-w5ynbewh	309	27	)	)	-RRB-
cord-289152-w5ynbewh	309	28	cells	cell	NNS
cord-289152-w5ynbewh	309	29	.	.	.
cord-289152-w5ynbewh	310	1	Cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	310	2	and	and	CC
cord-289152-w5ynbewh	310	3	nuclear	nuclear	JJ
cord-289152-w5ynbewh	310	4	protein	protein	NN
cord-289152-w5ynbewh	310	5	extracts	extract	NNS
cord-289152-w5ynbewh	310	6	from	from	IN
cord-289152-w5ynbewh	310	7	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	310	8	cells	cell	NNS
cord-289152-w5ynbewh	310	9	and	and	CC
cord-289152-w5ynbewh	310	10	PAM	PAM	NNP
cord-289152-w5ynbewh	310	11	cultures	culture	NNS
cord-289152-w5ynbewh	310	12	were	be	VBD
cord-289152-w5ynbewh	310	13	prepared	prepare	VBN
cord-289152-w5ynbewh	310	14	with	with	IN
cord-289152-w5ynbewh	310	15	the	the	DT
cord-289152-w5ynbewh	310	16	nuclear	nuclear	JJ
cord-289152-w5ynbewh	310	17	extraction	extraction	NN
cord-289152-w5ynbewh	310	18	kit	kit	NN
cord-289152-w5ynbewh	310	19	(	(	-LRB-
cord-289152-w5ynbewh	310	20	Active	active	JJ
cord-289152-w5ynbewh	310	21	Motif	Motif	NNP
cord-289152-w5ynbewh	310	22	,	,	,
cord-289152-w5ynbewh	310	23	Inc.	Inc.	NNP
cord-289152-w5ynbewh	310	24	,	,	,
cord-289152-w5ynbewh	310	25	Carlsbad	Carlsbad	NNP
cord-289152-w5ynbewh	310	26	,	,	,
cord-289152-w5ynbewh	310	27	CA	CA	NNP
cord-289152-w5ynbewh	310	28	)	)	-RRB-
cord-289152-w5ynbewh	310	29	according	accord	VBG
cord-289152-w5ynbewh	310	30	to	to	IN
cord-289152-w5ynbewh	310	31	the	the	DT
cord-289152-w5ynbewh	310	32	manufacturer	manufacturer	NN
cord-289152-w5ynbewh	310	33	's	's	POS
cord-289152-w5ynbewh	310	34	protocol	protocol	NN
cord-289152-w5ynbewh	310	35	.	.	.
cord-289152-w5ynbewh	311	1	Protein	protein	NN
cord-289152-w5ynbewh	311	2	concentration	concentration	NN
cord-289152-w5ynbewh	311	3	was	be	VBD
cord-289152-w5ynbewh	311	4	determined	determine	VBN
cord-289152-w5ynbewh	311	5	by	by	IN
cord-289152-w5ynbewh	311	6	the	the	DT
cord-289152-w5ynbewh	311	7	Bio	Bio	NNP
cord-289152-w5ynbewh	311	8	-	-	HYPH
cord-289152-w5ynbewh	311	9	Rad	Rad	NNP
cord-289152-w5ynbewh	311	10	protein	protein	NN
cord-289152-w5ynbewh	311	11	assay	assay	NN
cord-289152-w5ynbewh	311	12	(	(	-LRB-
cord-289152-w5ynbewh	311	13	Bio	Bio	NNP
cord-289152-w5ynbewh	311	14	-	-	HYPH
cord-289152-w5ynbewh	311	15	Rad	Rad	NNP
cord-289152-w5ynbewh	311	16	,	,	,
cord-289152-w5ynbewh	311	17	Hercules	Hercules	NNP
cord-289152-w5ynbewh	311	18	,	,	,
cord-289152-w5ynbewh	311	19	CA	CA	NNP
cord-289152-w5ynbewh	311	20	)	)	-RRB-
cord-289152-w5ynbewh	311	21	with	with	IN
cord-289152-w5ynbewh	311	22	bovine	bovine	JJ
cord-289152-w5ynbewh	311	23	serum	serum	NN
cord-289152-w5ynbewh	311	24	albumin	albumin	NN
cord-289152-w5ynbewh	311	25	as	as	IN
cord-289152-w5ynbewh	311	26	a	a	DT
cord-289152-w5ynbewh	311	27	standard	standard	NN
cord-289152-w5ynbewh	311	28	.	.	.
cord-289152-w5ynbewh	312	1	NF	nf	NN
cord-289152-w5ynbewh	312	2	-	-	HYPH
cord-289152-w5ynbewh	312	3	jB	jb	NN
cord-289152-w5ynbewh	313	1	p65	p65	NN
cord-289152-w5ynbewh	313	2	transcription	transcription	NN
cord-289152-w5ynbewh	313	3	factor	factor	NN
cord-289152-w5ynbewh	313	4	assay	assay	NN
cord-289152-w5ynbewh	313	5	NF	nf	NN
cord-289152-w5ynbewh	313	6	-	-	HYPH
cord-289152-w5ynbewh	313	7	nB	nB	NNP
cord-289152-w5ynbewh	313	8	binding	bind	VBG
cord-289152-w5ynbewh	313	9	to	to	IN
cord-289152-w5ynbewh	313	10	nB	nB	NNP
cord-289152-w5ynbewh	313	11	sites	site	NNS
cord-289152-w5ynbewh	313	12	was	be	VBD
cord-289152-w5ynbewh	313	13	assessed	assess	VBN
cord-289152-w5ynbewh	313	14	using	use	VBG
cord-289152-w5ynbewh	313	15	the	the	DT
cord-289152-w5ynbewh	313	16	Trans	Trans	NNP
cord-289152-w5ynbewh	313	17	-	-	NNP
cord-289152-w5ynbewh	313	18	AM	AM	NNP
cord-289152-w5ynbewh	313	19	NF	nf	NN
cord-289152-w5ynbewh	313	20	-	-	HYPH
cord-289152-w5ynbewh	313	21	nB	nB	NNP
cord-289152-w5ynbewh	313	22	p65	p65	NN
cord-289152-w5ynbewh	313	23	transcription	transcription	NN
cord-289152-w5ynbewh	313	24	factor	factor	NN
cord-289152-w5ynbewh	313	25	assay	assay	NN
cord-289152-w5ynbewh	313	26	kit	kit	NN
cord-289152-w5ynbewh	313	27	(	(	-LRB-
cord-289152-w5ynbewh	313	28	Active	active	JJ
cord-289152-w5ynbewh	313	29	Motif	Motif	NNP
cord-289152-w5ynbewh	313	30	,	,	,
cord-289152-w5ynbewh	313	31	Inc.	Inc.	NNP
cord-289152-w5ynbewh	313	32	,	,	,
cord-289152-w5ynbewh	313	33	Carlsbad	Carlsbad	NNP
cord-289152-w5ynbewh	313	34	,	,	,
cord-289152-w5ynbewh	313	35	CA	CA	NNP
cord-289152-w5ynbewh	313	36	)	)	-RRB-
cord-289152-w5ynbewh	313	37	.	.	.
cord-289152-w5ynbewh	314	1	In	in	IN
cord-289152-w5ynbewh	314	2	this	this	DT
cord-289152-w5ynbewh	314	3	assay	assay	NN
cord-289152-w5ynbewh	314	4	,	,	,
cord-289152-w5ynbewh	314	5	an	an	DT
cord-289152-w5ynbewh	314	6	oligonucleotide	oligonucleotide	NN
cord-289152-w5ynbewh	314	7	containing	contain	VBG
cord-289152-w5ynbewh	314	8	the	the	DT
cord-289152-w5ynbewh	314	9	NF	NF	NNP
cord-289152-w5ynbewh	314	10	-	-	HYPH
cord-289152-w5ynbewh	314	11	nB	nB	NNP
cord-289152-w5ynbewh	314	12	consensus	consensus	NN
cord-289152-w5ynbewh	314	13	site	site	NN
cord-289152-w5ynbewh	314	14	is	be	VBZ
cord-289152-w5ynbewh	314	15	attached	attach	VBN
cord-289152-w5ynbewh	314	16	to	to	IN
cord-289152-w5ynbewh	314	17	a	a	DT
cord-289152-w5ynbewh	314	18	96-well	96-well	CD
cord-289152-w5ynbewh	314	19	plate	plate	NN
cord-289152-w5ynbewh	314	20	.	.	.
cord-289152-w5ynbewh	315	1	The	the	DT
cord-289152-w5ynbewh	315	2	active	active	JJ
cord-289152-w5ynbewh	315	3	form	form	NN
cord-289152-w5ynbewh	315	4	of	of	IN
cord-289152-w5ynbewh	315	5	NF	nf	NN
cord-289152-w5ynbewh	315	6	-	-	HYPH
cord-289152-w5ynbewh	315	7	nB	nB	NNP
cord-289152-w5ynbewh	315	8	contained	contain	VBN
cord-289152-w5ynbewh	315	9	in	in	IN
cord-289152-w5ynbewh	315	10	cell	cell	NN
cord-289152-w5ynbewh	315	11	extracts	extract	NNS
cord-289152-w5ynbewh	315	12	specifically	specifically	RB
cord-289152-w5ynbewh	315	13	binds	bind	VBZ
cord-289152-w5ynbewh	315	14	to	to	IN
cord-289152-w5ynbewh	315	15	this	this	DT
cord-289152-w5ynbewh	315	16	oligonucleotide	oligonucleotide	NN
cord-289152-w5ynbewh	315	17	and	and	CC
cord-289152-w5ynbewh	315	18	can	can	MD
cord-289152-w5ynbewh	315	19	be	be	VB
cord-289152-w5ynbewh	315	20	revealed	reveal	VBN
cord-289152-w5ynbewh	315	21	by	by	IN
cord-289152-w5ynbewh	315	22	incubation	incubation	NN
cord-289152-w5ynbewh	315	23	with	with	IN
cord-289152-w5ynbewh	315	24	antibodies	antibody	NNS
cord-289152-w5ynbewh	315	25	using	use	VBG
cord-289152-w5ynbewh	315	26	enzyme	enzyme	NN
cord-289152-w5ynbewh	315	27	-	-	HYPH
cord-289152-w5ynbewh	315	28	linked	link	VBN
cord-289152-w5ynbewh	315	29	immunosorbent	immunosorbent	JJ
cord-289152-w5ynbewh	315	30	assay	assay	NN
cord-289152-w5ynbewh	315	31	technology	technology	NN
cord-289152-w5ynbewh	315	32	with	with	IN
cord-289152-w5ynbewh	315	33	absorbance	absorbance	NN
cord-289152-w5ynbewh	315	34	reading	reading	NN
cord-289152-w5ynbewh	315	35	.	.	.
cord-289152-w5ynbewh	316	1	Ten	ten	CD
cord-289152-w5ynbewh	316	2	microgram	microgram	NN
cord-289152-w5ynbewh	316	3	of	of	IN
cord-289152-w5ynbewh	316	4	nuclear	nuclear	JJ
cord-289152-w5ynbewh	316	5	proteins	protein	NNS
cord-289152-w5ynbewh	316	6	was	be	VBD
cord-289152-w5ynbewh	316	7	analyzed	analyze	VBN
cord-289152-w5ynbewh	316	8	for	for	IN
cord-289152-w5ynbewh	316	9	p65	p65	NN
cord-289152-w5ynbewh	316	10	binding	bind	VBG
cord-289152-w5ynbewh	316	11	to	to	IN
cord-289152-w5ynbewh	316	12	nB	nB	NNP
cord-289152-w5ynbewh	316	13	oligonucleotide	oligonucleotide	JJ
cord-289152-w5ynbewh	316	14	according	accord	VBG
cord-289152-w5ynbewh	316	15	to	to	IN
cord-289152-w5ynbewh	316	16	the	the	DT
cord-289152-w5ynbewh	316	17	manufacturer	manufacturer	NN
cord-289152-w5ynbewh	316	18	's	's	POS
cord-289152-w5ynbewh	316	19	instructions	instruction	NNS
cord-289152-w5ynbewh	316	20	.	.	.
cord-289152-w5ynbewh	317	1	The	the	DT
cord-289152-w5ynbewh	317	2	specificity	specificity	NN
cord-289152-w5ynbewh	317	3	of	of	IN
cord-289152-w5ynbewh	317	4	the	the	DT
cord-289152-w5ynbewh	317	5	assay	assay	NN
cord-289152-w5ynbewh	317	6	was	be	VBD
cord-289152-w5ynbewh	317	7	monitored	monitor	VBN
cord-289152-w5ynbewh	317	8	by	by	IN
cord-289152-w5ynbewh	317	9	competition	competition	NN
cord-289152-w5ynbewh	317	10	with	with	IN
cord-289152-w5ynbewh	317	11	free	free	JJ
cord-289152-w5ynbewh	317	12	wild	wild	JJ
cord-289152-w5ynbewh	317	13	-	-	HYPH
cord-289152-w5ynbewh	317	14	type	type	NN
cord-289152-w5ynbewh	317	15	nB	nB	NNP
cord-289152-w5ynbewh	317	16	consensus	consensus	NN
cord-289152-w5ynbewh	317	17	oligonucleotide	oligonucleotide	JJ
cord-289152-w5ynbewh	317	18	or	or	CC
cord-289152-w5ynbewh	317	19	mutated	mutate	VBN
cord-289152-w5ynbewh	317	20	nB	nB	NNP
cord-289152-w5ynbewh	317	21	consensus	consensus	NN
cord-289152-w5ynbewh	317	22	oligonucleotide	oligonucleotide	NN
cord-289152-w5ynbewh	317	23	.	.	.
cord-289152-w5ynbewh	318	1	MARC-145	marc-145	JJ
cord-289152-w5ynbewh	318	2	cells	cell	NNS
cord-289152-w5ynbewh	318	3	were	be	VBD
cord-289152-w5ynbewh	318	4	washed	wash	VBN
cord-289152-w5ynbewh	318	5	three	three	CD
cord-289152-w5ynbewh	318	6	times	time	NNS
cord-289152-w5ynbewh	318	7	with	with	IN
cord-289152-w5ynbewh	318	8	PBS	PBS	NNP
cord-289152-w5ynbewh	318	9	,	,	,
cord-289152-w5ynbewh	318	10	fixed	fix	VBN
cord-289152-w5ynbewh	318	11	and	and	CC
cord-289152-w5ynbewh	318	12	permeabilized	permeabilize	VBN
cord-289152-w5ynbewh	318	13	in	in	IN
cord-289152-w5ynbewh	318	14	cold	cold	JJ
cord-289152-w5ynbewh	318	15	methanol	methanol	NN
cord-289152-w5ynbewh	318	16	for	for	IN
cord-289152-w5ynbewh	318	17	10	10	CD
cord-289152-w5ynbewh	318	18	min	min	NN
cord-289152-w5ynbewh	318	19	at	at	IN
cord-289152-w5ynbewh	318	20	4	4	CD
cord-289152-w5ynbewh	318	21	-C	-C	NNS
cord-289152-w5ynbewh	318	22	,	,	,
cord-289152-w5ynbewh	318	23	and	and	CC
cord-289152-w5ynbewh	318	24	washed	wash	VBD
cord-289152-w5ynbewh	318	25	three	three	CD
cord-289152-w5ynbewh	318	26	times	time	NNS
cord-289152-w5ynbewh	318	27	with	with	IN
cord-289152-w5ynbewh	318	28	PBS	PBS	NNP
cord-289152-w5ynbewh	318	29	.	.	.
cord-289152-w5ynbewh	319	1	Cells	cell	NNS
cord-289152-w5ynbewh	319	2	were	be	VBD
cord-289152-w5ynbewh	319	3	incubated	incubate	VBN
cord-289152-w5ynbewh	319	4	for	for	IN
cord-289152-w5ynbewh	319	5	1	1	CD
cord-289152-w5ynbewh	319	6	h	h	NN
cord-289152-w5ynbewh	319	7	at	at	IN
cord-289152-w5ynbewh	319	8	room	room	NN
cord-289152-w5ynbewh	319	9	temperature	temperature	NN
cord-289152-w5ynbewh	319	10	(	(	-LRB-
cord-289152-w5ynbewh	319	11	RT	RT	NNP
cord-289152-w5ynbewh	319	12	)	)	-RRB-
cord-289152-w5ynbewh	319	13	with	with	IN
cord-289152-w5ynbewh	319	14	a	a	DT
cord-289152-w5ynbewh	319	15	1:500	1:500	CD
cord-289152-w5ynbewh	319	16	dilution	dilution	NN
cord-289152-w5ynbewh	319	17	of	of	IN
cord-289152-w5ynbewh	319	18	primary	primary	JJ
cord-289152-w5ynbewh	319	19	mouse	mouse	NN
cord-289152-w5ynbewh	319	20	anti	anti	JJ
cord-289152-w5ynbewh	319	21	-	-	JJ
cord-289152-w5ynbewh	319	22	NF	nf	NN
cord-289152-w5ynbewh	319	23	-	-	HYPH
cord-289152-w5ynbewh	319	24	nB	nb	NN
cord-289152-w5ynbewh	319	25	p65	p65	NN
cord-289152-w5ynbewh	319	26	antibody	antibody	NN
cord-289152-w5ynbewh	319	27	(	(	-LRB-
cord-289152-w5ynbewh	319	28	Santa	Santa	NNP
cord-289152-w5ynbewh	319	29	Cruz	Cruz	NNP
cord-289152-w5ynbewh	319	30	Biotechnology	Biotechnology	NNP
cord-289152-w5ynbewh	319	31	,	,	,
cord-289152-w5ynbewh	319	32	Santa	Santa	NNP
cord-289152-w5ynbewh	319	33	Cruz	Cruz	NNP
cord-289152-w5ynbewh	319	34	,	,	,
cord-289152-w5ynbewh	319	35	CA	CA	NNP
cord-289152-w5ynbewh	319	36	)	)	-RRB-
cord-289152-w5ynbewh	319	37	.	.	.
cord-289152-w5ynbewh	320	1	The	the	DT
cord-289152-w5ynbewh	320	2	cells	cell	NNS
cord-289152-w5ynbewh	320	3	were	be	VBD
cord-289152-w5ynbewh	320	4	then	then	RB
cord-289152-w5ynbewh	320	5	washed	wash	VBN
cord-289152-w5ynbewh	320	6	five	five	CD
cord-289152-w5ynbewh	320	7	times	time	NNS
cord-289152-w5ynbewh	320	8	in	in	IN
cord-289152-w5ynbewh	320	9	PBS	PBS	NNP
cord-289152-w5ynbewh	320	10	followed	follow	VBN
cord-289152-w5ynbewh	320	11	by	by	IN
cord-289152-w5ynbewh	320	12	incubation	incubation	NN
cord-289152-w5ynbewh	320	13	for	for	IN
cord-289152-w5ynbewh	320	14	1	1	CD
cord-289152-w5ynbewh	320	15	h	h	NN
cord-289152-w5ynbewh	320	16	with	with	IN
cord-289152-w5ynbewh	320	17	the	the	DT
cord-289152-w5ynbewh	320	18	anti	anti	JJ
cord-289152-w5ynbewh	320	19	-	-	JJ
cord-289152-w5ynbewh	320	20	mouse	mouse	JJ
cord-289152-w5ynbewh	320	21	IgG	IgG	NNP
cord-289152-w5ynbewh	320	22	secondary	secondary	JJ
cord-289152-w5ynbewh	320	23	antibody	antibody	NN
cord-289152-w5ynbewh	320	24	conjugated	conjugate	VBN
cord-289152-w5ynbewh	320	25	with	with	IN
cord-289152-w5ynbewh	320	26	FITC	FITC	NNP
cord-289152-w5ynbewh	320	27	(	(	-LRB-
cord-289152-w5ynbewh	320	28	Sigma	Sigma	NNP
cord-289152-w5ynbewh	320	29	,	,	,
cord-289152-w5ynbewh	320	30	St.	St.	NNP
cord-289152-w5ynbewh	320	31	Louis	Louis	NNP
cord-289152-w5ynbewh	320	32	,	,	,
cord-289152-w5ynbewh	320	33	MO	MO	NNP
cord-289152-w5ynbewh	320	34	)	)	-RRB-
cord-289152-w5ynbewh	320	35	.	.	.
cord-289152-w5ynbewh	321	1	The	the	DT
cord-289152-w5ynbewh	321	2	cells	cell	NNS
cord-289152-w5ynbewh	321	3	were	be	VBD
cord-289152-w5ynbewh	321	4	washed	wash	VBN
cord-289152-w5ynbewh	321	5	again	again	RB
cord-289152-w5ynbewh	321	6	with	with	IN
cord-289152-w5ynbewh	321	7	PBS	PBS	NNP
cord-289152-w5ynbewh	321	8	and	and	CC
cord-289152-w5ynbewh	321	9	then	then	RB
cord-289152-w5ynbewh	321	10	examined	examine	VBD
cord-289152-w5ynbewh	321	11	with	with	IN
cord-289152-w5ynbewh	321	12	an	an	DT
cord-289152-w5ynbewh	321	13	Olympus	Olympus	NNP
cord-289152-w5ynbewh	321	14	1X70	1x70	CD
cord-289152-w5ynbewh	321	15	microscope	microscope	NN
cord-289152-w5ynbewh	321	16	fitted	fit	VBN
cord-289152-w5ynbewh	321	17	with	with	IN
cord-289152-w5ynbewh	321	18	a	a	DT
cord-289152-w5ynbewh	321	19	Bio	Bio	NNP
cord-289152-w5ynbewh	321	20	-	-	HYPH
cord-289152-w5ynbewh	321	21	Rad	Rad	NNP
cord-289152-w5ynbewh	321	22	MRC-600	MRC-600	NNP
cord-289152-w5ynbewh	321	23	confocal	confocal	JJ
cord-289152-w5ynbewh	321	24	laser	laser	NN
cord-289152-w5ynbewh	321	25	(	(	-LRB-
cord-289152-w5ynbewh	321	26	Bio	Bio	NNP
cord-289152-w5ynbewh	321	27	-	-	HYPH
cord-289152-w5ynbewh	321	28	Rad	Rad	NNP
cord-289152-w5ynbewh	321	29	,	,	,
cord-289152-w5ynbewh	321	30	Hercules	Hercules	NNP
cord-289152-w5ynbewh	321	31	,	,	,
cord-289152-w5ynbewh	321	32	CA	CA	NNP
cord-289152-w5ynbewh	321	33	)	)	-RRB-
cord-289152-w5ynbewh	321	34	.	.	.
cord-289152-w5ynbewh	322	1	Western	western	JJ
cord-289152-w5ynbewh	322	2	blotting	blotting	NN
cord-289152-w5ynbewh	322	3	was	be	VBD
cord-289152-w5ynbewh	322	4	performed	perform	VBN
cord-289152-w5ynbewh	322	5	by	by	IN
cord-289152-w5ynbewh	322	6	utilizing	utilize	VBG
cord-289152-w5ynbewh	322	7	a	a	DT
cord-289152-w5ynbewh	322	8	standard	standard	JJ
cord-289152-w5ynbewh	322	9	protocol	protocol	NN
cord-289152-w5ynbewh	322	10	(	(	-LRB-
cord-289152-w5ynbewh	322	11	Davis	Davis	NNP
cord-289152-w5ynbewh	322	12	et	et	NNP
cord-289152-w5ynbewh	322	13	al	al	NNP
cord-289152-w5ynbewh	322	14	.	.	NNP
cord-289152-w5ynbewh	322	15	,	,	,
cord-289152-w5ynbewh	322	16	1994	1994	CD
cord-289152-w5ynbewh	322	17	)	)	-RRB-
cord-289152-w5ynbewh	322	18	.	.	.
cord-289152-w5ynbewh	323	1	Briefly	briefly	RB
cord-289152-w5ynbewh	323	2	,	,	,
cord-289152-w5ynbewh	323	3	cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	323	4	or	or	CC
cord-289152-w5ynbewh	323	5	nuclear	nuclear	JJ
cord-289152-w5ynbewh	323	6	extracts	extract	NNS
cord-289152-w5ynbewh	323	7	were	be	VBD
cord-289152-w5ynbewh	323	8	diluted	dilute	VBN
cord-289152-w5ynbewh	323	9	(	(	-LRB-
cord-289152-w5ynbewh	323	10	2:1	2:1	CD
cord-289152-w5ynbewh	323	11	)	)	-RRB-
cord-289152-w5ynbewh	323	12	in	in	IN
cord-289152-w5ynbewh	323	13	2Â	2â	CD
cord-289152-w5ynbewh	323	14	sample	sample	NN
cord-289152-w5ynbewh	323	15	buffer	buffer	NN
cord-289152-w5ynbewh	323	16	and	and	CC
cord-289152-w5ynbewh	323	17	boiled	boil	VBN
cord-289152-w5ynbewh	323	18	for	for	IN
cord-289152-w5ynbewh	323	19	5	5	CD
cord-289152-w5ynbewh	323	20	min	min	NN
cord-289152-w5ynbewh	323	21	.	.	.
cord-289152-w5ynbewh	324	1	Twenty	twenty	CD
cord-289152-w5ynbewh	324	2	micrograms	microgram	NNS
cord-289152-w5ynbewh	324	3	of	of	IN
cord-289152-w5ynbewh	324	4	each	each	DT
cord-289152-w5ynbewh	324	5	extract	extract	NN
cord-289152-w5ynbewh	324	6	was	be	VBD
cord-289152-w5ynbewh	324	7	subjected	subject	VBN
cord-289152-w5ynbewh	324	8	to	to	IN
cord-289152-w5ynbewh	324	9	sodium	sodium	NN
cord-289152-w5ynbewh	324	10	dodecyl	dodecyl	NNP
cord-289152-w5ynbewh	324	11	sulfate	sulfate	NN
cord-289152-w5ynbewh	324	12	-	-	HYPH
cord-289152-w5ynbewh	324	13	polyacrylamide	polyacrylamide	NN
cord-289152-w5ynbewh	324	14	gel	gel	NN
cord-289152-w5ynbewh	324	15	electrophoresis	electrophoresis	NN
cord-289152-w5ynbewh	324	16	(	(	-LRB-
cord-289152-w5ynbewh	324	17	SDS	SDS	NNP
cord-289152-w5ynbewh	324	18	-	-	HYPH
cord-289152-w5ynbewh	324	19	PAGE	PAGE	NNP
cord-289152-w5ynbewh	324	20	)	)	-RRB-
cord-289152-w5ynbewh	324	21	and	and	CC
cord-289152-w5ynbewh	324	22	transferred	transfer	VBN
cord-289152-w5ynbewh	324	23	to	to	IN
cord-289152-w5ynbewh	324	24	a	a	DT
cord-289152-w5ynbewh	324	25	nitrocellulose	nitrocellulose	JJ
cord-289152-w5ynbewh	324	26	membrane	membrane	NN
cord-289152-w5ynbewh	324	27	(	(	-LRB-
cord-289152-w5ynbewh	324	28	Amersham	Amersham	NNP
cord-289152-w5ynbewh	324	29	Biosciences	Biosciences	NNP
cord-289152-w5ynbewh	324	30	,	,	,
cord-289152-w5ynbewh	324	31	Piscataway	Piscataway	NNP
cord-289152-w5ynbewh	324	32	,	,	,
cord-289152-w5ynbewh	324	33	NJ	NJ	NNP
cord-289152-w5ynbewh	324	34	)	)	-RRB-
cord-289152-w5ynbewh	324	35	.	.	.
cord-289152-w5ynbewh	325	1	The	the	DT
cord-289152-w5ynbewh	325	2	membrane	membrane	NN
cord-289152-w5ynbewh	325	3	was	be	VBD
cord-289152-w5ynbewh	325	4	washed	wash	VBN
cord-289152-w5ynbewh	325	5	with	with	IN
cord-289152-w5ynbewh	325	6	phosphate	phosphate	NN
cord-289152-w5ynbewh	325	7	-	-	HYPH
cord-289152-w5ynbewh	325	8	buffered	buffer	VBN
cord-289152-w5ynbewh	325	9	saline	saline	NN
cord-289152-w5ynbewh	325	10	-	-	HYPH
cord-289152-w5ynbewh	325	11	Tween	Tween	NNP
cord-289152-w5ynbewh	325	12	20	20	CD
cord-289152-w5ynbewh	325	13	(	(	-LRB-
cord-289152-w5ynbewh	325	14	TPBS	TPBS	NNP
cord-289152-w5ynbewh	325	15	)	)	-RRB-
cord-289152-w5ynbewh	325	16	,	,	,
cord-289152-w5ynbewh	325	17	blocked	block	VBN
cord-289152-w5ynbewh	325	18	in	in	IN
cord-289152-w5ynbewh	325	19	a	a	DT
cord-289152-w5ynbewh	325	20	solution	solution	NN
cord-289152-w5ynbewh	325	21	of	of	IN
cord-289152-w5ynbewh	325	22	TPBS	TPBS	NNP
cord-289152-w5ynbewh	325	23	containing	contain	VBG
cord-289152-w5ynbewh	325	24	5	5	CD
cord-289152-w5ynbewh	325	25	%	%	NN
cord-289152-w5ynbewh	325	26	nonfat	nonfat	JJ
cord-289152-w5ynbewh	325	27	dry	dry	JJ
cord-289152-w5ynbewh	325	28	milk	milk	NN
cord-289152-w5ynbewh	325	29	,	,	,
cord-289152-w5ynbewh	325	30	and	and	CC
cord-289152-w5ynbewh	325	31	then	then	RB
cord-289152-w5ynbewh	325	32	washed	wash	VBD
cord-289152-w5ynbewh	325	33	three	three	CD
cord-289152-w5ynbewh	325	34	times	time	NNS
cord-289152-w5ynbewh	325	35	.	.	.
cord-289152-w5ynbewh	326	1	The	the	DT
cord-289152-w5ynbewh	326	2	membrane	membrane	NN
cord-289152-w5ynbewh	326	3	was	be	VBD
cord-289152-w5ynbewh	326	4	then	then	RB
cord-289152-w5ynbewh	326	5	incubated	incubate	VBN
cord-289152-w5ynbewh	326	6	with	with	IN
cord-289152-w5ynbewh	326	7	primary	primary	JJ
cord-289152-w5ynbewh	326	8	antibody	antibody	NN
cord-289152-w5ynbewh	326	9	overnight	overnight	RB
cord-289152-w5ynbewh	326	10	at	at	IN
cord-289152-w5ynbewh	326	11	4	4	CD
cord-289152-w5ynbewh	326	12	-C	-C	NNS
cord-289152-w5ynbewh	326	13	or	or	CC
cord-289152-w5ynbewh	326	14	1	1	CD
cord-289152-w5ynbewh	326	15	h	h	NN
cord-289152-w5ynbewh	326	16	at	at	IN
cord-289152-w5ynbewh	326	17	RT	RT	NNP
cord-289152-w5ynbewh	326	18	,	,	,
cord-289152-w5ynbewh	326	19	washed	wash	VBD
cord-289152-w5ynbewh	326	20	three	three	CD
cord-289152-w5ynbewh	326	21	times	time	NNS
cord-289152-w5ynbewh	326	22	with	with	IN
cord-289152-w5ynbewh	326	23	TPBS	TPBS	NNP
cord-289152-w5ynbewh	326	24	,	,	,
cord-289152-w5ynbewh	326	25	and	and	CC
cord-289152-w5ynbewh	326	26	incubated	incubate	VBN
cord-289152-w5ynbewh	326	27	with	with	IN
cord-289152-w5ynbewh	326	28	the	the	DT
cord-289152-w5ynbewh	326	29	secondary	secondary	JJ
cord-289152-w5ynbewh	326	30	antibody	antibody	NN
cord-289152-w5ynbewh	326	31	horseradish	horseradish	NN
cord-289152-w5ynbewh	326	32	peroxidase	peroxidase	NN
cord-289152-w5ynbewh	326	33	(	(	-LRB-
cord-289152-w5ynbewh	326	34	HRP	HRP	NNP
cord-289152-w5ynbewh	326	35	)	)	-RRB-
cord-289152-w5ynbewh	326	36	conjugate	conjugate	NN
cord-289152-w5ynbewh	326	37	solution	solution	NN
cord-289152-w5ynbewh	326	38	for	for	IN
cord-289152-w5ynbewh	326	39	1	1	CD
cord-289152-w5ynbewh	326	40	h	h	NN
cord-289152-w5ynbewh	326	41	at	at	IN
cord-289152-w5ynbewh	326	42	RT	RT	NNP
cord-289152-w5ynbewh	326	43	.	.	.
cord-289152-w5ynbewh	327	1	Samples	sample	NNS
cord-289152-w5ynbewh	327	2	were	be	VBD
cord-289152-w5ynbewh	327	3	washed	wash	VBN
cord-289152-w5ynbewh	327	4	three	three	CD
cord-289152-w5ynbewh	327	5	times	time	NNS
cord-289152-w5ynbewh	327	6	with	with	IN
cord-289152-w5ynbewh	327	7	TPBS	TPBS	NNP
cord-289152-w5ynbewh	327	8	,	,	,
cord-289152-w5ynbewh	327	9	and	and	CC
cord-289152-w5ynbewh	327	10	then	then	RB
cord-289152-w5ynbewh	327	11	the	the	DT
cord-289152-w5ynbewh	327	12	signal	signal	NN
cord-289152-w5ynbewh	327	13	was	be	VBD
cord-289152-w5ynbewh	327	14	detected	detect	VBN
cord-289152-w5ynbewh	327	15	with	with	IN
cord-289152-w5ynbewh	327	16	the	the	DT
cord-289152-w5ynbewh	327	17	chemiluminescent	chemiluminescent	NN
cord-289152-w5ynbewh	327	18	protein	protein	NN
cord-289152-w5ynbewh	327	19	detection	detection	NN
cord-289152-w5ynbewh	327	20	system	system	NN
cord-289152-w5ynbewh	327	21	(	(	-LRB-
cord-289152-w5ynbewh	327	22	Amersham	Amersham	NNP
cord-289152-w5ynbewh	327	23	Biosciences	Biosciences	NNP
cord-289152-w5ynbewh	327	24	,	,	,
cord-289152-w5ynbewh	327	25	Piscataway	Piscataway	NNP
cord-289152-w5ynbewh	327	26	,	,	,
cord-289152-w5ynbewh	327	27	NJ	NJ	NNP
cord-289152-w5ynbewh	327	28	)	)	-RRB-
cord-289152-w5ynbewh	327	29	.	.	.
cord-289152-w5ynbewh	328	1	Antibodies	antibody	NNS
cord-289152-w5ynbewh	328	2	used	use	VBN
cord-289152-w5ynbewh	328	3	for	for	IN
cord-289152-w5ynbewh	328	4	Western	western	JJ
cord-289152-w5ynbewh	328	5	blot	blot	NN
cord-289152-w5ynbewh	328	6	are	be	VBP
cord-289152-w5ynbewh	328	7	anti	anti	JJ
cord-289152-w5ynbewh	328	8	-	-	JJ
cord-289152-w5ynbewh	328	9	NF	nf	NN
cord-289152-w5ynbewh	328	10	-	-	HYPH
cord-289152-w5ynbewh	328	11	nB	nb	NN
cord-289152-w5ynbewh	328	12	p65	p65	ADD
cord-289152-w5ynbewh	328	13	(	(	-LRB-
cord-289152-w5ynbewh	328	14	Santa	Santa	NNP
cord-289152-w5ynbewh	328	15	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	16	Biotechnology	Biotechnology	NNP
cord-289152-w5ynbewh	328	17	,	,	,
cord-289152-w5ynbewh	328	18	Santa	Santa	NNP
cord-289152-w5ynbewh	328	19	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	20	,	,	,
cord-289152-w5ynbewh	328	21	CA	CA	NNP
cord-289152-w5ynbewh	328	22	)	)	-RRB-
cord-289152-w5ynbewh	328	23	,	,	,
cord-289152-w5ynbewh	328	24	anti	anti	JJ
cord-289152-w5ynbewh	328	25	-	-	NNS
cord-289152-w5ynbewh	328	26	InBa	inba	JJ
cord-289152-w5ynbewh	328	27	(	(	-LRB-
cord-289152-w5ynbewh	328	28	Cell	cell	NN
cord-289152-w5ynbewh	328	29	Signaling	Signaling	NNP
cord-289152-w5ynbewh	328	30	,	,	,
cord-289152-w5ynbewh	328	31	Beverly	Beverly	NNP
cord-289152-w5ynbewh	328	32	,	,	,
cord-289152-w5ynbewh	328	33	MA	MA	NNP
cord-289152-w5ynbewh	328	34	)	)	-RRB-
cord-289152-w5ynbewh	328	35	,	,	,
cord-289152-w5ynbewh	328	36	anti	anti	NNP
cord-289152-w5ynbewh	328	37	-	-	JJ
cord-289152-w5ynbewh	328	38	InBh	inbh	JJ
cord-289152-w5ynbewh	328	39	(	(	-LRB-
cord-289152-w5ynbewh	328	40	Santa	Santa	NNP
cord-289152-w5ynbewh	328	41	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	42	Biotechnology	Biotechnology	NNP
cord-289152-w5ynbewh	328	43	,	,	,
cord-289152-w5ynbewh	328	44	Santa	Santa	NNP
cord-289152-w5ynbewh	328	45	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	46	,	,	,
cord-289152-w5ynbewh	328	47	CA	CA	NNP
cord-289152-w5ynbewh	328	48	)	)	-RRB-
cord-289152-w5ynbewh	328	49	,	,	,
cord-289152-w5ynbewh	328	50	anti	anti	JJ
cord-289152-w5ynbewh	328	51	-	-	JJ
cord-289152-w5ynbewh	328	52	InBq	inbq	JJ
cord-289152-w5ynbewh	328	53	(	(	-LRB-
cord-289152-w5ynbewh	328	54	Santa	Santa	NNP
cord-289152-w5ynbewh	328	55	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	56	Biotechnology	Biotechnology	NNP
cord-289152-w5ynbewh	328	57	,	,	,
cord-289152-w5ynbewh	328	58	Santa	Santa	NNP
cord-289152-w5ynbewh	328	59	Cruz	Cruz	NNP
cord-289152-w5ynbewh	328	60	,	,	,
cord-289152-w5ynbewh	328	61	CA	CA	NNP
cord-289152-w5ynbewh	328	62	)	)	-RRB-
cord-289152-w5ynbewh	328	63	,	,	,
cord-289152-w5ynbewh	328	64	anti	anti	JJ
cord-289152-w5ynbewh	328	65	-	-	JJ
cord-289152-w5ynbewh	328	66	rabbit	rabbit	JJ
cord-289152-w5ynbewh	328	67	IgG	IgG	NNP
cord-289152-w5ynbewh	328	68	-	-	HYPH
cord-289152-w5ynbewh	328	69	HRP	HRP	NNP
cord-289152-w5ynbewh	328	70	(	(	-LRB-
cord-289152-w5ynbewh	328	71	Amersham	Amersham	NNP
cord-289152-w5ynbewh	328	72	Biosciences	Biosciences	NNP
cord-289152-w5ynbewh	328	73	,	,	,
cord-289152-w5ynbewh	328	74	Piscataway	Piscataway	NNP
cord-289152-w5ynbewh	328	75	,	,	,
cord-289152-w5ynbewh	328	76	NJ	NJ	NNP
cord-289152-w5ynbewh	328	77	)	)	-RRB-
cord-289152-w5ynbewh	328	78	,	,	,
cord-289152-w5ynbewh	328	79	and	and	CC
cord-289152-w5ynbewh	328	80	anti	anti	JJ
cord-289152-w5ynbewh	328	81	-	-	JJ
cord-289152-w5ynbewh	328	82	actin	actin	JJ
cord-289152-w5ynbewh	328	83	(	(	-LRB-
cord-289152-w5ynbewh	328	84	Sigma	Sigma	NNP
cord-289152-w5ynbewh	328	85	,	,	,
cord-289152-w5ynbewh	328	86	St.	St.	NNP
cord-289152-w5ynbewh	328	87	Louis	Louis	NNP
cord-289152-w5ynbewh	328	88	,	,	,
cord-289152-w5ynbewh	328	89	MO	MO	NNP
cord-289152-w5ynbewh	328	90	)	)	-RRB-
cord-289152-w5ynbewh	328	91	.	.	.
cord-289152-w5ynbewh	329	1	Cells	cell	NNS
cord-289152-w5ynbewh	329	2	were	be	VBD
cord-289152-w5ynbewh	329	3	treated	treat	VBN
cord-289152-w5ynbewh	329	4	with	with	IN
cord-289152-w5ynbewh	329	5	2V,7V	2v,7v	CD
cord-289152-w5ynbewh	329	6	-	-	HYPH
cord-289152-w5ynbewh	329	7	dichlorofluorescein	dichlorofluorescein	NN
cord-289152-w5ynbewh	329	8	diacetate	diacetate	NN
cord-289152-w5ynbewh	329	9	(	(	-LRB-
cord-289152-w5ynbewh	329	10	DCFH	DCFH	NNP
cord-289152-w5ynbewh	329	11	-	-	HYPH
cord-289152-w5ynbewh	329	12	DA	DA	NNP
cord-289152-w5ynbewh	329	13	,	,	,
cord-289152-w5ynbewh	329	14	Calbiochem	Calbiochem	NNP
cord-289152-w5ynbewh	329	15	,	,	,
cord-289152-w5ynbewh	329	16	La	La	NNP
cord-289152-w5ynbewh	329	17	Jolla	Jolla	NNP
cord-289152-w5ynbewh	329	18	,	,	,
cord-289152-w5ynbewh	329	19	CA	CA	NNP
cord-289152-w5ynbewh	329	20	)	)	-RRB-
cord-289152-w5ynbewh	329	21	for	for	IN
cord-289152-w5ynbewh	329	22	15	15	CD
cord-289152-w5ynbewh	329	23	min	min	NN
cord-289152-w5ynbewh	329	24	and	and	CC
cord-289152-w5ynbewh	329	25	washed	wash	VBD
cord-289152-w5ynbewh	329	26	twice	twice	RB
cord-289152-w5ynbewh	329	27	with	with	IN
cord-289152-w5ynbewh	329	28	PBS	PBS	NNP
cord-289152-w5ynbewh	329	29	.	.	.
cord-289152-w5ynbewh	330	1	The	the	DT
cord-289152-w5ynbewh	330	2	cells	cell	NNS
cord-289152-w5ynbewh	330	3	were	be	VBD
cord-289152-w5ynbewh	330	4	observed	observe	VBN
cord-289152-w5ynbewh	330	5	under	under	IN
cord-289152-w5ynbewh	330	6	a	a	DT
cord-289152-w5ynbewh	330	7	fluorescence	fluorescence	NN
cord-289152-w5ynbewh	330	8	microscope	microscope	NN
cord-289152-w5ynbewh	330	9	.	.	.
cord-289152-w5ynbewh	331	1	The	the	DT
cord-289152-w5ynbewh	331	2	antioxidants	antioxidant	NNS
cord-289152-w5ynbewh	331	3	used	use	VBN
cord-289152-w5ynbewh	331	4	in	in	IN
cord-289152-w5ynbewh	331	5	this	this	DT
cord-289152-w5ynbewh	331	6	study	study	NN
cord-289152-w5ynbewh	331	7	were	be	VBD
cord-289152-w5ynbewh	331	8	N	n	NN
cord-289152-w5ynbewh	331	9	-	-	HYPH
cord-289152-w5ynbewh	331	10	acetyl	acetyl	NNP
cord-289152-w5ynbewh	331	11	-	-	HYPH
cord-289152-w5ynbewh	331	12	lcysteine	lcysteine	NNP
cord-289152-w5ynbewh	331	13	(	(	-LRB-
cord-289152-w5ynbewh	331	14	NAC	NAC	NNP
cord-289152-w5ynbewh	331	15	;	;	:
cord-289152-w5ynbewh	331	16	Calbiochem	Calbiochem	NNP
cord-289152-w5ynbewh	331	17	,	,	,
cord-289152-w5ynbewh	331	18	La	La	NNP
cord-289152-w5ynbewh	331	19	Jolla	Jolla	NNP
cord-289152-w5ynbewh	331	20	,	,	,
cord-289152-w5ynbewh	331	21	CA	CA	NNP
cord-289152-w5ynbewh	331	22	)	)	-RRB-
cord-289152-w5ynbewh	331	23	in	in	IN
cord-289152-w5ynbewh	331	24	PBS	PBS	NNP
cord-289152-w5ynbewh	331	25	and	and	CC
cord-289152-w5ynbewh	331	26	pyrollidine	pyrollidine	NN
cord-289152-w5ynbewh	331	27	dithiocarbamate	dithiocarbamate	NNP
cord-289152-w5ynbewh	331	28	(	(	-LRB-
cord-289152-w5ynbewh	331	29	PDTC	PDTC	NNP
cord-289152-w5ynbewh	331	30	;	;	:
cord-289152-w5ynbewh	331	31	Sigma	Sigma	NNP
cord-289152-w5ynbewh	331	32	,	,	,
cord-289152-w5ynbewh	331	33	St.	St.	NNP
cord-289152-w5ynbewh	331	34	Louis	Louis	NNP
cord-289152-w5ynbewh	331	35	,	,	,
cord-289152-w5ynbewh	331	36	MO	MO	NNP
cord-289152-w5ynbewh	331	37	)	)	-RRB-
cord-289152-w5ynbewh	331	38	in	in	IN
cord-289152-w5ynbewh	331	39	PBS	PBS	NNP
cord-289152-w5ynbewh	331	40	.	.	.
cord-289152-w5ynbewh	332	1	Concentrations	concentration	NNS
cord-289152-w5ynbewh	332	2	which	which	WDT
cord-289152-w5ynbewh	332	3	did	do	VBD
cord-289152-w5ynbewh	332	4	not	not	RB
cord-289152-w5ynbewh	332	5	show	show	VB
cord-289152-w5ynbewh	332	6	cytotoxicity	cytotoxicity	NN
cord-289152-w5ynbewh	332	7	were	be	VBD
cord-289152-w5ynbewh	332	8	used	use	VBN
cord-289152-w5ynbewh	332	9	in	in	IN
cord-289152-w5ynbewh	332	10	this	this	DT
cord-289152-w5ynbewh	332	11	study	study	NN
cord-289152-w5ynbewh	332	12	.	.	.
cord-289152-w5ynbewh	333	1	None	none	NN
cord-289152-w5ynbewh	333	2	of	of	IN
cord-289152-w5ynbewh	333	3	the	the	DT
cord-289152-w5ynbewh	333	4	solvents	solvent	NNS
cord-289152-w5ynbewh	333	5	alone	alone	RB
cord-289152-w5ynbewh	333	6	affected	affect	VBD
cord-289152-w5ynbewh	333	7	NF	nf	NN
cord-289152-w5ynbewh	333	8	-	-	HYPH
cord-289152-w5ynbewh	333	9	nB	nB	NNP
cord-289152-w5ynbewh	333	10	activation	activation	NN
cord-289152-w5ynbewh	333	11	in	in	IN
cord-289152-w5ynbewh	333	12	the	the	DT
cord-289152-w5ynbewh	333	13	concentrations	concentration	NNS
cord-289152-w5ynbewh	333	14	used	use	VBN
cord-289152-w5ynbewh	333	15	in	in	IN
cord-289152-w5ynbewh	333	16	this	this	DT
cord-289152-w5ynbewh	333	17	study	study	NN
cord-289152-w5ynbewh	333	18	(	(	-LRB-
cord-289152-w5ynbewh	333	19	data	datum	NNS
cord-289152-w5ynbewh	333	20	not	not	RB
cord-289152-w5ynbewh	333	21	shown	show	VBN
cord-289152-w5ynbewh	333	22	)	)	-RRB-
cord-289152-w5ynbewh	333	23	.	.	.
cord-289152-w5ynbewh	334	1	Extraction	extraction	NN
cord-289152-w5ynbewh	334	2	of	of	IN
cord-289152-w5ynbewh	334	3	RNA	RNA	NNP
cord-289152-w5ynbewh	334	4	was	be	VBD
cord-289152-w5ynbewh	334	5	performed	perform	VBN
cord-289152-w5ynbewh	334	6	using	use	VBG
cord-289152-w5ynbewh	334	7	Trizol	Trizol	NNP
cord-289152-w5ynbewh	334	8	(	(	-LRB-
cord-289152-w5ynbewh	334	9	Invitrogen	Invitrogen	NNP
cord-289152-w5ynbewh	334	10	,	,	,
cord-289152-w5ynbewh	334	11	Carlsbad	Carlsbad	NNP
cord-289152-w5ynbewh	334	12	,	,	,
cord-289152-w5ynbewh	334	13	CA	CA	NNP
cord-289152-w5ynbewh	334	14	)	)	-RRB-
cord-289152-w5ynbewh	334	15	,	,	,
cord-289152-w5ynbewh	334	16	and	and	CC
cord-289152-w5ynbewh	334	17	the	the	DT
cord-289152-w5ynbewh	334	18	Nucleospin	Nucleospin	NNP
cord-289152-w5ynbewh	334	19	RNA	RNA	NNP
cord-289152-w5ynbewh	334	20	II	II	NNP
cord-289152-w5ynbewh	334	21	kit	kit	NN
cord-289152-w5ynbewh	334	22	(	(	-LRB-
cord-289152-w5ynbewh	334	23	BD	BD	NNP
cord-289152-w5ynbewh	334	24	Biosciences	Biosciences	NNP
cord-289152-w5ynbewh	334	25	Inc.	Inc.	NNP
cord-289152-w5ynbewh	334	26	,	,	,
cord-289152-w5ynbewh	334	27	Palo	Palo	NNP
cord-289152-w5ynbewh	334	28	Alto	Alto	NNP
cord-289152-w5ynbewh	334	29	,	,	,
cord-289152-w5ynbewh	334	30	CA	CA	NNP
cord-289152-w5ynbewh	334	31	)	)	-RRB-
cord-289152-w5ynbewh	335	1	with	with	IN
cord-289152-w5ynbewh	335	2	DNase	DNase	NNP
cord-289152-w5ynbewh	335	3	I	-PRON-	PRP
cord-289152-w5ynbewh	335	4	digestion	digestion	NN
cord-289152-w5ynbewh	335	5	performed	perform	VBN
cord-289152-w5ynbewh	335	6	directly	directly	RB
cord-289152-w5ynbewh	335	7	on	on	IN
cord-289152-w5ynbewh	335	8	the	the	DT
cord-289152-w5ynbewh	335	9	spin	spin	NN
cord-289152-w5ynbewh	335	10	column	column	NN
cord-289152-w5ynbewh	335	11	according	accord	VBG
cord-289152-w5ynbewh	335	12	to	to	IN
cord-289152-w5ynbewh	335	13	the	the	DT
cord-289152-w5ynbewh	335	14	manufacturer	manufacturer	NN
cord-289152-w5ynbewh	335	15	's	's	POS
cord-289152-w5ynbewh	335	16	instructions	instruction	NNS
cord-289152-w5ynbewh	335	17	.	.	.
cord-289152-w5ynbewh	336	1	Heterologous	Heterologous	NNP
cord-289152-w5ynbewh	336	2	competitor	competitor	NN
cord-289152-w5ynbewh	336	3	RNA	RNA	NNP
cord-289152-w5ynbewh	336	4	for	for	IN
cord-289152-w5ynbewh	336	5	quantification	quantification	NN
cord-289152-w5ynbewh	336	6	of	of	IN
cord-289152-w5ynbewh	336	7	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	336	8	,	,	,
cord-289152-w5ynbewh	336	9	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	336	10	,	,	,
cord-289152-w5ynbewh	336	11	or	or	CC
cord-289152-w5ynbewh	336	12	cyclophilin	cyclophilin	NNP
cord-289152-w5ynbewh	336	13	was	be	VBD
cord-289152-w5ynbewh	336	14	synthesized	synthesize	VBN
cord-289152-w5ynbewh	336	15	using	use	VBG
cord-289152-w5ynbewh	336	16	the	the	DT
cord-289152-w5ynbewh	336	17	respective	respective	JJ
cord-289152-w5ynbewh	336	18	real	real	JJ
cord-289152-w5ynbewh	336	19	-	-	HYPH
cord-289152-w5ynbewh	336	20	time	time	NN
cord-289152-w5ynbewh	336	21	RT	RT	NNP
cord-289152-w5ynbewh	336	22	-	-	HYPH
cord-289152-w5ynbewh	336	23	PCR	PCR	NNP
cord-289152-w5ynbewh	336	24	primer	primer	NN
cord-289152-w5ynbewh	336	25	sequences	sequence	NNS
cord-289152-w5ynbewh	336	26	in	in	IN
cord-289152-w5ynbewh	336	27	a	a	DT
cord-289152-w5ynbewh	336	28	methodology	methodology	NN
cord-289152-w5ynbewh	336	29	previously	previously	RB
cord-289152-w5ynbewh	336	30	described	describe	VBN
cord-289152-w5ynbewh	336	31	(	(	-LRB-
cord-289152-w5ynbewh	336	32	Kleiboeker	Kleiboeker	NNP
cord-289152-w5ynbewh	336	33	,	,	,
cord-289152-w5ynbewh	336	34	2003	2003	CD
cord-289152-w5ynbewh	336	35	)	)	-RRB-
cord-289152-w5ynbewh	336	36	.	.	.
cord-289152-w5ynbewh	337	1	The	the	DT
cord-289152-w5ynbewh	337	2	concentration	concentration	NN
cord-289152-w5ynbewh	337	3	of	of	IN
cord-289152-w5ynbewh	337	4	purified	purify	VBN
cord-289152-w5ynbewh	337	5	competitor	competitor	NN
cord-289152-w5ynbewh	337	6	RNA	RNA	NNP
cord-289152-w5ynbewh	337	7	was	be	VBD
cord-289152-w5ynbewh	337	8	estimated	estimate	VBN
cord-289152-w5ynbewh	337	9	by	by	IN
cord-289152-w5ynbewh	337	10	measuring	measure	VBG
cord-289152-w5ynbewh	337	11	the	the	DT
cord-289152-w5ynbewh	337	12	absorbance	absorbance	NN
cord-289152-w5ynbewh	337	13	at	at	IN
cord-289152-w5ynbewh	337	14	260	260	CD
cord-289152-w5ynbewh	337	15	nm	nm	NN
cord-289152-w5ynbewh	337	16	,	,	,
cord-289152-w5ynbewh	337	17	and	and	CC
cord-289152-w5ynbewh	337	18	the	the	DT
cord-289152-w5ynbewh	337	19	purity	purity	NN
cord-289152-w5ynbewh	337	20	was	be	VBD
cord-289152-w5ynbewh	337	21	assessed	assess	VBN
cord-289152-w5ynbewh	337	22	by	by	IN
cord-289152-w5ynbewh	337	23	determining	determine	VBG
cord-289152-w5ynbewh	337	24	the	the	DT
cord-289152-w5ynbewh	337	25	ratio	ratio	NN
cord-289152-w5ynbewh	337	26	of	of	IN
cord-289152-w5ynbewh	337	27	absorbance	absorbance	NN
cord-289152-w5ynbewh	337	28	at	at	IN
cord-289152-w5ynbewh	337	29	260	260	CD
cord-289152-w5ynbewh	337	30	nm	nm	NN
cord-289152-w5ynbewh	337	31	to	to	IN
cord-289152-w5ynbewh	337	32	the	the	DT
cord-289152-w5ynbewh	337	33	absorbance	absorbance	NN
cord-289152-w5ynbewh	337	34	at	at	IN
cord-289152-w5ynbewh	337	35	280	280	CD
cord-289152-w5ynbewh	337	36	nm	nm	NN
cord-289152-w5ynbewh	337	37	.	.	.
cord-289152-w5ynbewh	338	1	Samples	sample	NNS
cord-289152-w5ynbewh	338	2	were	be	VBD
cord-289152-w5ynbewh	338	3	considered	consider	VBN
cord-289152-w5ynbewh	338	4	to	to	TO
cord-289152-w5ynbewh	338	5	be	be	VB
cord-289152-w5ynbewh	338	6	relatively	relatively	RB
cord-289152-w5ynbewh	338	7	pure	pure	JJ
cord-289152-w5ynbewh	338	8	and	and	CC
cord-289152-w5ynbewh	338	9	suitable	suitable	JJ
cord-289152-w5ynbewh	338	10	for	for	IN
cord-289152-w5ynbewh	338	11	use	use	NN
cord-289152-w5ynbewh	338	12	as	as	IN
cord-289152-w5ynbewh	338	13	quantification	quantification	NN
cord-289152-w5ynbewh	338	14	standards	standard	NNS
cord-289152-w5ynbewh	338	15	if	if	IN
cord-289152-w5ynbewh	338	16	the	the	DT
cord-289152-w5ynbewh	338	17	ratio	ratio	NN
cord-289152-w5ynbewh	338	18	was	be	VBD
cord-289152-w5ynbewh	338	19	!	!	.
cord-289152-w5ynbewh	339	1	2.0	2.0	CD
cord-289152-w5ynbewh	339	2	.	.	.
cord-289152-w5ynbewh	340	1	Following	follow	VBG
cord-289152-w5ynbewh	340	2	purification	purification	NN
cord-289152-w5ynbewh	340	3	,	,	,
cord-289152-w5ynbewh	340	4	the	the	DT
cord-289152-w5ynbewh	340	5	RNA	RNA	NNP
cord-289152-w5ynbewh	340	6	was	be	VBD
cord-289152-w5ynbewh	340	7	serially	serially	RB
cord-289152-w5ynbewh	340	8	diluted	dilute	VBN
cord-289152-w5ynbewh	340	9	in	in	IN
cord-289152-w5ynbewh	340	10	RNase	rnase	NN
cord-289152-w5ynbewh	340	11	-	-	HYPH
cord-289152-w5ynbewh	340	12	free	free	JJ
cord-289152-w5ynbewh	340	13	dH	dh	NN
cord-289152-w5ynbewh	340	14	2	2	CD
cord-289152-w5ynbewh	340	15	O	o	NN
cord-289152-w5ynbewh	340	16	and	and	CC
cord-289152-w5ynbewh	340	17	stored	store	VBN
cord-289152-w5ynbewh	340	18	as	as	IN
cord-289152-w5ynbewh	340	19	aliquots	aliquot	NNS
cord-289152-w5ynbewh	340	20	at	at	IN
cord-289152-w5ynbewh	340	21	À80	À80	NNP
cord-289152-w5ynbewh	340	22	-C.	-c.	NN
cord-289152-w5ynbewh	341	1	The	the	DT
cord-289152-w5ynbewh	341	2	number	number	NN
cord-289152-w5ynbewh	341	3	of	of	IN
cord-289152-w5ynbewh	341	4	molecules	molecule	NNS
cord-289152-w5ynbewh	341	5	of	of	IN
cord-289152-w5ynbewh	341	6	competitor	competitor	NN
cord-289152-w5ynbewh	341	7	RNA	RNA	NNP
cord-289152-w5ynbewh	341	8	/	/	SYM
cord-289152-w5ynbewh	341	9	Al	Al	NNP
cord-289152-w5ynbewh	341	10	was	be	VBD
cord-289152-w5ynbewh	341	11	estimated	estimate	VBN
cord-289152-w5ynbewh	341	12	based	base	VBN
cord-289152-w5ynbewh	341	13	on	on	IN
cord-289152-w5ynbewh	341	14	the	the	DT
cord-289152-w5ynbewh	341	15	RNA	RNA	NNP
cord-289152-w5ynbewh	341	16	concentration	concentration	NN
cord-289152-w5ynbewh	341	17	and	and	CC
cord-289152-w5ynbewh	341	18	the	the	DT
cord-289152-w5ynbewh	341	19	molecular	molecular	JJ
cord-289152-w5ynbewh	341	20	weight	weight	NN
cord-289152-w5ynbewh	341	21	of	of	IN
cord-289152-w5ynbewh	341	22	the	the	DT
cord-289152-w5ynbewh	341	23	transcript	transcript	NN
cord-289152-w5ynbewh	341	24	.	.	.
cord-289152-w5ynbewh	342	1	Amplification	amplification	NN
cord-289152-w5ynbewh	342	2	of	of	IN
cord-289152-w5ynbewh	342	3	2	2	CD
cord-289152-w5ynbewh	342	4	Al	Al	NNP
cord-289152-w5ynbewh	342	5	RNA	RNA	NNP
cord-289152-w5ynbewh	342	6	was	be	VBD
cord-289152-w5ynbewh	342	7	performed	perform	VBN
cord-289152-w5ynbewh	342	8	using	use	VBG
cord-289152-w5ynbewh	342	9	the	the	DT
cord-289152-w5ynbewh	342	10	Qiagen	Qiagen	NNP
cord-289152-w5ynbewh	342	11	QuantiTect	QuantiTect	NNP
cord-289152-w5ynbewh	342	12	Probe	Probe	NNP
cord-289152-w5ynbewh	342	13	RT	RT	NNP
cord-289152-w5ynbewh	342	14	-	-	HYPH
cord-289152-w5ynbewh	342	15	PCR	PCR	NNP
cord-289152-w5ynbewh	342	16	kit	kit	NN
cord-289152-w5ynbewh	342	17	(	(	-LRB-
cord-289152-w5ynbewh	342	18	Qiagen	Qiagen	NNP
cord-289152-w5ynbewh	342	19	Inc.	Inc.	NNP
cord-289152-w5ynbewh	342	20	,	,	,
cord-289152-w5ynbewh	342	21	Valencia	Valencia	NNP
cord-289152-w5ynbewh	342	22	,	,	,
cord-289152-w5ynbewh	342	23	CA	CA	NNP
cord-289152-w5ynbewh	342	24	)	)	-RRB-
cord-289152-w5ynbewh	342	25	with	with	IN
cord-289152-w5ynbewh	342	26	thermocycling	thermocycling	NN
cord-289152-w5ynbewh	342	27	,	,	,
cord-289152-w5ynbewh	342	28	and	and	CC
cord-289152-w5ynbewh	342	29	detection	detection	NN
cord-289152-w5ynbewh	342	30	was	be	VBD
cord-289152-w5ynbewh	342	31	performed	perform	VBN
cord-289152-w5ynbewh	342	32	in	in	IN
cord-289152-w5ynbewh	342	33	a	a	DT
cord-289152-w5ynbewh	342	34	Stratagene	Stratagene	NNP
cord-289152-w5ynbewh	342	35	Mx4000	Mx4000	NNP
cord-289152-w5ynbewh	342	36	(	(	-LRB-
cord-289152-w5ynbewh	342	37	Stratagene	Stratagene	NNP
cord-289152-w5ynbewh	342	38	Inc.	Inc.	NNP
cord-289152-w5ynbewh	342	39	,	,	,
cord-289152-w5ynbewh	342	40	La	La	NNP
cord-289152-w5ynbewh	342	41	Jolla	Jolla	NNP
cord-289152-w5ynbewh	342	42	,	,	,
cord-289152-w5ynbewh	342	43	CA	CA	NNP
cord-289152-w5ynbewh	342	44	)	)	-RRB-
cord-289152-w5ynbewh	342	45	.	.	.
cord-289152-w5ynbewh	343	1	Samples	sample	NNS
cord-289152-w5ynbewh	343	2	were	be	VBD
cord-289152-w5ynbewh	343	3	analyzed	analyze	VBN
cord-289152-w5ynbewh	343	4	in	in	IN
cord-289152-w5ynbewh	343	5	triplicate	triplicate	NN
cord-289152-w5ynbewh	343	6	.	.	.
cord-289152-w5ynbewh	344	1	Thermocycling	thermocycling	NN
cord-289152-w5ynbewh	344	2	conditions	condition	NNS
cord-289152-w5ynbewh	344	3	were	be	VBD
cord-289152-w5ynbewh	344	4	:	:	:
cord-289152-w5ynbewh	344	5	50	50	CD
cord-289152-w5ynbewh	344	6	-C	-C	NNS
cord-289152-w5ynbewh	344	7	(	(	-LRB-
cord-289152-w5ynbewh	344	8	30	30	CD
cord-289152-w5ynbewh	344	9	min	min	NN
cord-289152-w5ynbewh	344	10	)	)	-RRB-
cord-289152-w5ynbewh	344	11	,	,	.
cord-289152-w5ynbewh	345	1	95	95	CD
cord-289152-w5ynbewh	345	2	-C	-C	:
cord-289152-w5ynbewh	345	3	(	(	-LRB-
cord-289152-w5ynbewh	345	4	15	15	CD
cord-289152-w5ynbewh	345	5	min	min	NN
cord-289152-w5ynbewh	345	6	)	)	-RRB-
cord-289152-w5ynbewh	345	7	,	,	.
cord-289152-w5ynbewh	346	1	followed	follow	VBN
cord-289152-w5ynbewh	346	2	by	by	IN
cord-289152-w5ynbewh	346	3	40	40	CD
cord-289152-w5ynbewh	346	4	cycles	cycle	NNS
cord-289152-w5ynbewh	346	5	of	of	IN
cord-289152-w5ynbewh	346	6	denaturation	denaturation	NN
cord-289152-w5ynbewh	346	7	(	(	-LRB-
cord-289152-w5ynbewh	346	8	94	94	CD
cord-289152-w5ynbewh	346	9	-C	-C	NNS
cord-289152-w5ynbewh	346	10	,	,	,
cord-289152-w5ynbewh	346	11	15	15	CD
cord-289152-w5ynbewh	346	12	s	s	NNPS
cord-289152-w5ynbewh	346	13	)	)	-RRB-
cord-289152-w5ynbewh	346	14	and	and	CC
cord-289152-w5ynbewh	346	15	annealing/	annealing/	NNP
cord-289152-w5ynbewh	346	16	extension	extension	NN
cord-289152-w5ynbewh	346	17	(	(	-LRB-
cord-289152-w5ynbewh	346	18	60	60	CD
cord-289152-w5ynbewh	346	19	-C	-C	NNS
cord-289152-w5ynbewh	346	20	,	,	,
cord-289152-w5ynbewh	346	21	60	60	CD
cord-289152-w5ynbewh	346	22	s	s	NN
cord-289152-w5ynbewh	346	23	)	)	-RRB-
cord-289152-w5ynbewh	346	24	.	.	.
cord-289152-w5ynbewh	347	1	The	the	DT
cord-289152-w5ynbewh	347	2	primers	primer	NNS
cord-289152-w5ynbewh	347	3	and	and	CC
cord-289152-w5ynbewh	347	4	probe	probe	NN
cord-289152-w5ynbewh	347	5	used	use	VBN
cord-289152-w5ynbewh	347	6	for	for	IN
cord-289152-w5ynbewh	347	7	5	5	CD
cord-289152-w5ynbewh	347	8	exonuclease	exonuclease	NN
cord-289152-w5ynbewh	347	9	(	(	-LRB-
cord-289152-w5ynbewh	347	10	TaqMan	TaqMan	NNP
cord-289152-w5ynbewh	347	11	)	)	-RRB-
cord-289152-w5ynbewh	347	12	amplification	amplification	NN
cord-289152-w5ynbewh	347	13	of	of	IN
cord-289152-w5ynbewh	347	14	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	347	15	were	be	VBD
cord-289152-w5ynbewh	347	16	5V	5v	JJ
cord-289152-w5ynbewh	347	17	-	-	HYPH
cord-289152-w5ynbewh	347	18	CCACCACAACATCACCTATTGG-3V	ccaccacaacatcacctattgg-3v	NN
cord-289152-w5ynbewh	347	19	(	(	-LRB-
cord-289152-w5ynbewh	347	20	forward	forward	RB
cord-289152-w5ynbewh	347	21	)	)	-RRB-
cord-289152-w5ynbewh	347	22	,	,	,
cord-289152-w5ynbewh	347	23	5V	5V	NNP
cord-289152-w5ynbewh	347	24	-	-	HYPH
cord-289152-w5ynbewh	347	25	GAA	GAA	NNP
cord-289152-w5ynbewh	347	26	-	-	HYPH
cord-289152-w5ynbewh	347	27	GGCGCGGGCAAA-3V	GGCGCGGGCAAA-3V	NNP
cord-289152-w5ynbewh	347	28	(	(	-LRB-
cord-289152-w5ynbewh	347	29	reverse	reverse	NN
cord-289152-w5ynbewh	347	30	)	)	-RRB-
cord-289152-w5ynbewh	347	31	,	,	,
cord-289152-w5ynbewh	347	32	and	and	CC
cord-289152-w5ynbewh	347	33	6-FAM	6-fam	CD
cord-289152-w5ynbewh	347	34	-	-	HYPH
cord-289152-w5ynbewh	347	35	TCCAAAA	TCCAAAA	NNP
cord-289152-w5ynbewh	347	36	-	-	HYPH
cord-289152-w5ynbewh	347	37	CTACTCGGAAGACTTGCCGC	CTACTCGGAAGACTTGCCGC	NNP
cord-289152-w5ynbewh	347	38	-	-	HYPH
cord-289152-w5ynbewh	347	39	BHQ1	BHQ1	NNP
cord-289152-w5ynbewh	347	40	-	-	HYPH
cord-289152-w5ynbewh	347	41	3V	3V	NNP
cord-289152-w5ynbewh	347	42	(	(	-LRB-
cord-289152-w5ynbewh	347	43	probe	probe	NN
cord-289152-w5ynbewh	347	44	)	)	-RRB-
cord-289152-w5ynbewh	347	45	.	.	.
cord-289152-w5ynbewh	348	1	The	the	DT
cord-289152-w5ynbewh	348	2	primers	primer	NNS
cord-289152-w5ynbewh	348	3	and	and	CC
cord-289152-w5ynbewh	348	4	probe	probe	NN
cord-289152-w5ynbewh	348	5	used	use	VBN
cord-289152-w5ynbewh	348	6	for	for	IN
cord-289152-w5ynbewh	348	7	5V	5v	JJ
cord-289152-w5ynbewh	348	8	exonuclease	exonuclease	NN
cord-289152-w5ynbewh	348	9	(	(	-LRB-
cord-289152-w5ynbewh	348	10	TaqMan	TaqMan	NNP
cord-289152-w5ynbewh	348	11	)	)	-RRB-
cord-289152-w5ynbewh	348	12	amplification	amplification	NN
cord-289152-w5ynbewh	348	13	of	of	IN
cord-289152-w5ynbewh	348	14	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	348	15	were	be	VBD
cord-289152-w5ynbewh	348	16	5V	5v	JJ
cord-289152-w5ynbewh	348	17	-	-	HYPH
cord-289152-w5ynbewh	348	18	CCGTCGCCCATCAT	ccgtcgcccatcat	NN
cord-289152-w5ynbewh	348	19	-	-	,
cord-289152-w5ynbewh	348	20	CAA-3V	CAA-3V	NNP
cord-289152-w5ynbewh	348	21	(	(	-LRB-
cord-289152-w5ynbewh	348	22	forward	forward	RB
cord-289152-w5ynbewh	348	23	)	)	-RRB-
cord-289152-w5ynbewh	348	24	,	,	.
cord-289152-w5ynbewh	349	1	5V	5V	NNP
cord-289152-w5ynbewh	349	2	-	-	HYPH
cord-289152-w5ynbewh	349	3	CAGGTATTGCACTGCCAACTCT-3V	CAGGTATTGCACTGCCAACTCT-3V	NNP
cord-289152-w5ynbewh	349	4	(	(	-LRB-
cord-289152-w5ynbewh	349	5	reverse	reverse	VB
cord-289152-w5ynbewh	349	6	)	)	-RRB-
cord-289152-w5ynbewh	349	7	,	,	,
cord-289152-w5ynbewh	349	8	and	and	CC
cord-289152-w5ynbewh	349	9	6-FAM	6-fam	CD
cord-289152-w5ynbewh	349	10	-	-	HYPH
cord-289152-w5ynbewh	349	11	CGATGTCGCCCCCAAAACGGA	CGATGTCGCCCCCAAAACGGA	NNP
cord-289152-w5ynbewh	349	12	-	-	HYPH
cord-289152-w5ynbewh	349	13	BHQ1	BHQ1	NNP
cord-289152-w5ynbewh	349	14	-	-	HYPH
cord-289152-w5ynbewh	349	15	3	3	NNP
cord-289152-w5ynbewh	349	16	(	(	-LRB-
cord-289152-w5ynbewh	349	17	probe	probe	NN
cord-289152-w5ynbewh	349	18	)	)	-RRB-
cord-289152-w5ynbewh	349	19	.	.	.
cord-289152-w5ynbewh	350	1	Amplification	amplification	NN
cord-289152-w5ynbewh	350	2	of	of	IN
cord-289152-w5ynbewh	350	3	cyclophilin	cyclophilin	NNP
cord-289152-w5ynbewh	350	4	was	be	VBD
cord-289152-w5ynbewh	350	5	performed	perform	VBN
cord-289152-w5ynbewh	350	6	as	as	IN
cord-289152-w5ynbewh	350	7	previously	previously	RB
cord-289152-w5ynbewh	350	8	described	describe	VBN
cord-289152-w5ynbewh	350	9	(	(	-LRB-
cord-289152-w5ynbewh	350	10	Miller	Miller	NNP
cord-289152-w5ynbewh	350	11	et	et	NNP
cord-289152-w5ynbewh	350	12	al	al	NNP
cord-289152-w5ynbewh	350	13	.	.	NNP
cord-289152-w5ynbewh	350	14	,	,	,
cord-289152-w5ynbewh	350	15	2004	2004	CD
cord-289152-w5ynbewh	350	16	)	)	-RRB-
cord-289152-w5ynbewh	350	17	and	and	CC
cord-289152-w5ynbewh	350	18	was	be	VBD
cord-289152-w5ynbewh	350	19	used	use	VBN
cord-289152-w5ynbewh	350	20	for	for	IN
cord-289152-w5ynbewh	350	21	normalization	normalization	NN
cord-289152-w5ynbewh	350	22	of	of	IN
cord-289152-w5ynbewh	350	23	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	350	24	and	and	CC
cord-289152-w5ynbewh	350	25	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	350	26	transcript	transcript	NN
cord-289152-w5ynbewh	350	27	quantities	quantity	NNS
cord-289152-w5ynbewh	350	28	.	.	.
cord-289152-w5ynbewh	351	1	All	all	DT
cord-289152-w5ynbewh	351	2	oligonucleotide	oligonucleotide	JJ
cord-289152-w5ynbewh	351	3	primers	primer	NNS
cord-289152-w5ynbewh	351	4	were	be	VBD
cord-289152-w5ynbewh	351	5	used	use	VBN
cord-289152-w5ynbewh	351	6	at	at	IN
cord-289152-w5ynbewh	351	7	a	a	DT
cord-289152-w5ynbewh	351	8	final	final	JJ
cord-289152-w5ynbewh	351	9	concentration	concentration	NN
cord-289152-w5ynbewh	351	10	of	of	IN
cord-289152-w5ynbewh	351	11	0.3	0.3	CD
cord-289152-w5ynbewh	351	12	AM	am	NN
cord-289152-w5ynbewh	351	13	,	,	,
cord-289152-w5ynbewh	351	14	and	and	CC
cord-289152-w5ynbewh	351	15	the	the	DT
cord-289152-w5ynbewh	351	16	dual	dual	RB
cord-289152-w5ynbewh	351	17	-	-	HYPH
cord-289152-w5ynbewh	351	18	labeled	label	VBN
cord-289152-w5ynbewh	351	19	probes	probe	NNS
cord-289152-w5ynbewh	351	20	were	be	VBD
cord-289152-w5ynbewh	351	21	used	use	VBN
cord-289152-w5ynbewh	351	22	at	at	IN
cord-289152-w5ynbewh	351	23	a	a	DT
cord-289152-w5ynbewh	351	24	final	final	JJ
cord-289152-w5ynbewh	351	25	concentration	concentration	NN
cord-289152-w5ynbewh	351	26	of	of	IN
cord-289152-w5ynbewh	351	27	0.2	0.2	CD
cord-289152-w5ynbewh	351	28	AM	am	NN
cord-289152-w5ynbewh	351	29	.	.	.
cord-289152-w5ynbewh	352	1	All	all	DT
cord-289152-w5ynbewh	352	2	oligonucleotide	oligonucleotide	JJ
cord-289152-w5ynbewh	352	3	primers	primer	NNS
cord-289152-w5ynbewh	352	4	and	and	CC
cord-289152-w5ynbewh	352	5	probes	probe	NNS
cord-289152-w5ynbewh	352	6	were	be	VBD
cord-289152-w5ynbewh	352	7	synthesized	synthesize	VBN
cord-289152-w5ynbewh	352	8	by	by	IN
cord-289152-w5ynbewh	352	9	Integrated	Integrated	NNP
cord-289152-w5ynbewh	352	10	DNA	DNA	NNP
cord-289152-w5ynbewh	352	11	Technologies	Technologies	NNP
cord-289152-w5ynbewh	352	12	,	,	,
cord-289152-w5ynbewh	353	1	Inc.	Inc.	NNP
cord-289152-w5ynbewh	353	2	(	(	-LRB-
cord-289152-w5ynbewh	353	3	Coralville	Coralville	NNP
cord-289152-w5ynbewh	353	4	,	,	,
cord-289152-w5ynbewh	353	5	IA	IA	NNP
cord-289152-w5ynbewh	353	6	)	)	-RRB-
cord-289152-w5ynbewh	353	7	.	.	.
cord-289152-w5ynbewh	354	1	The	the	DT
cord-289152-w5ynbewh	354	2	relative	relative	JJ
cord-289152-w5ynbewh	354	3	copy	copy	NN
cord-289152-w5ynbewh	354	4	numbers	number	NNS
cord-289152-w5ynbewh	354	5	of	of	IN
cord-289152-w5ynbewh	354	6	MMP-2	MMP-2	NNP
cord-289152-w5ynbewh	354	7	and	and	CC
cord-289152-w5ynbewh	354	8	MMP-9	MMP-9	NNP
cord-289152-w5ynbewh	355	1	compared	compare	VBN
cord-289152-w5ynbewh	355	2	to	to	IN
cord-289152-w5ynbewh	355	3	cyclophilin	cyclophilin	NNP
cord-289152-w5ynbewh	355	4	were	be	VBD
cord-289152-w5ynbewh	355	5	determined	determine	VBN
cord-289152-w5ynbewh	355	6	as	as	IN
cord-289152-w5ynbewh	355	7	previously	previously	RB
cord-289152-w5ynbewh	355	8	described	describe	VBN
cord-289152-w5ynbewh	355	9	(	(	-LRB-
cord-289152-w5ynbewh	355	10	Pfaffl	Pfaffl	NNP
cord-289152-w5ynbewh	355	11	,	,	,
cord-289152-w5ynbewh	355	12	2001	2001	CD
cord-289152-w5ynbewh	355	13	)	)	-RRB-
cord-289152-w5ynbewh	355	14	.	.	.
cord-289152-w5ynbewh	356	1	The	the	DT
cord-289152-w5ynbewh	356	2	Student	Student	NNP
cord-289152-w5ynbewh	356	3	's	's	POS
cord-289152-w5ynbewh	356	4	t	t	NN
cord-289152-w5ynbewh	356	5	test	test	NN
cord-289152-w5ynbewh	356	6	was	be	VBD
cord-289152-w5ynbewh	356	7	used	use	VBN
cord-289152-w5ynbewh	356	8	for	for	IN
cord-289152-w5ynbewh	356	9	the	the	DT
cord-289152-w5ynbewh	356	10	statistical	statistical	JJ
cord-289152-w5ynbewh	356	11	analyses	analysis	NNS
cord-289152-w5ynbewh	356	12	.	.	.
cord-289152-w5ynbewh	357	1	P	p	NN
cord-289152-w5ynbewh	357	2	values	value	NNS
cord-289152-w5ynbewh	357	3	of	of	IN
cord-289152-w5ynbewh	357	4	less	less	JJR
cord-289152-w5ynbewh	357	5	than	than	IN
cord-289152-w5ynbewh	357	6	0.05	0.05	CD
cord-289152-w5ynbewh	357	7	were	be	VBD
cord-289152-w5ynbewh	357	8	considered	consider	VBN
cord-289152-w5ynbewh	357	9	statistically	statistically	RB
cord-289152-w5ynbewh	357	10	significant	significant	JJ
cord-289152-w5ynbewh	357	11	.	.	.
cord-289152-w5ynbewh	358	1	Interferon	interferon	NN
cord-289152-w5ynbewh	358	2	-	-	HYPH
cord-289152-w5ynbewh	358	3	alpha	alpha	NN
cord-289152-w5ynbewh	358	4	response	response	NN
cord-289152-w5ynbewh	358	5	to	to	IN
cord-289152-w5ynbewh	358	6	swine	swine	NNP
cord-289152-w5ynbewh	358	7	arterivirus	arterivirus	NNP
cord-289152-w5ynbewh	358	8	(	(	-LRB-
cord-289152-w5ynbewh	358	9	PoAV	PoAV	NNP
cord-289152-w5ynbewh	358	10	)	)	-RRB-
cord-289152-w5ynbewh	358	11	,	,	,
cord-289152-w5ynbewh	358	12	the	the	DT
cord-289152-w5ynbewh	358	13	porcine	porcine	JJ
cord-289152-w5ynbewh	358	14	reproductive	reproductive	JJ
cord-289152-w5ynbewh	358	15	and	and	CC
cord-289152-w5ynbewh	358	16	respiratory	respiratory	JJ
cord-289152-w5ynbewh	358	17	syndrome	syndrome	NN
cord-289152-w5ynbewh	358	18	virus	virus	NN
cord-289152-w5ynbewh	358	19	Immune	immune	JJ
cord-289152-w5ynbewh	358	20	responses	response	NNS
cord-289152-w5ynbewh	358	21	in	in	IN
cord-289152-w5ynbewh	358	22	pigs	pig	NNS
cord-289152-w5ynbewh	358	23	infected	infect	VBN
cord-289152-w5ynbewh	358	24	with	with	IN
cord-289152-w5ynbewh	358	25	porcine	porcine	JJ
cord-289152-w5ynbewh	358	26	reproductive	reproductive	JJ
cord-289152-w5ynbewh	358	27	and	and	CC
cord-289152-w5ynbewh	358	28	respiratory	respiratory	JJ
cord-289152-w5ynbewh	358	29	syndrome	syndrome	NN
cord-289152-w5ynbewh	358	30	virus	virus	NN
cord-289152-w5ynbewh	358	31	(	(	-LRB-
cord-289152-w5ynbewh	358	32	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	358	33	)	)	-RRB-
cord-289152-w5ynbewh	359	1	Constitutive	constitutive	JJ
cord-289152-w5ynbewh	359	2	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	359	3	of	of	IN
cord-289152-w5ynbewh	359	4	I	I	NNP
cord-289152-w5ynbewh	359	5	kappa	kappa	NN
cord-289152-w5ynbewh	359	6	B	B	NNP
cord-289152-w5ynbewh	359	7	alpha	alpha	NN
cord-289152-w5ynbewh	359	8	by	by	IN
cord-289152-w5ynbewh	359	9	casein	casein	NN
cord-289152-w5ynbewh	359	10	kinase	kinase	NNP
cord-289152-w5ynbewh	359	11	II	ii	CD
cord-289152-w5ynbewh	359	12	Neutrality	neutrality	NN
cord-289152-w5ynbewh	359	13	of	of	IN
cord-289152-w5ynbewh	359	14	the	the	DT
cord-289152-w5ynbewh	359	15	canonical	canonical	JJ
cord-289152-w5ynbewh	359	16	NF	nf	NN
cord-289152-w5ynbewh	359	17	-	-	HYPH
cord-289152-w5ynbewh	359	18	kappaBdependent	kappabdependent	JJ
cord-289152-w5ynbewh	359	19	pathway	pathway	NN
cord-289152-w5ynbewh	359	20	for	for	IN
cord-289152-w5ynbewh	359	21	human	human	JJ
cord-289152-w5ynbewh	359	22	and	and	CC
cord-289152-w5ynbewh	359	23	murine	murine	JJ
cord-289152-w5ynbewh	359	24	cytomegalovirus	cytomegalovirus	NN
cord-289152-w5ynbewh	359	25	transcription	transcription	NN
cord-289152-w5ynbewh	359	26	and	and	CC
cord-289152-w5ynbewh	359	27	replication	replication	NN
cord-289152-w5ynbewh	359	28	in	in	IN
cord-289152-w5ynbewh	359	29	vitro	vitro	FW
cord-289152-w5ynbewh	359	30	Characterization	characterization	NN
cord-289152-w5ynbewh	359	31	of	of	IN
cord-289152-w5ynbewh	359	32	swine	swine	NN
cord-289152-w5ynbewh	359	33	infertility	infertility	NN
cord-289152-w5ynbewh	359	34	and	and	CC
cord-289152-w5ynbewh	359	35	respiratory	respiratory	JJ
cord-289152-w5ynbewh	359	36	syndrome	syndrome	NN
cord-289152-w5ynbewh	359	37	(	(	-LRB-
cord-289152-w5ynbewh	359	38	SIRS	SIRS	NNP
cord-289152-w5ynbewh	359	39	)	)	-RRB-
cord-289152-w5ynbewh	359	40	virus	virus	NN
cord-289152-w5ynbewh	359	41	(	(	-LRB-
cord-289152-w5ynbewh	359	42	isolate	isolate	VB
cord-289152-w5ynbewh	359	43	ATCC	ATCC	NNP
cord-289152-w5ynbewh	359	44	VR-2332	vr-2332	NN
cord-289152-w5ynbewh	359	45	)	)	-RRB-
cord-289152-w5ynbewh	360	1	Temporal	temporal	JJ
cord-289152-w5ynbewh	360	2	activation	activation	NN
cord-289152-w5ynbewh	360	3	of	of	IN
cord-289152-w5ynbewh	360	4	NF	NF	NNP
cord-289152-w5ynbewh	360	5	-	-	HYPH
cord-289152-w5ynbewh	360	6	kappaB	kappaB	NNP
cord-289152-w5ynbewh	360	7	regulates	regulate	VBZ
cord-289152-w5ynbewh	360	8	an	an	DT
cord-289152-w5ynbewh	360	9	interferon	interferon	NN
cord-289152-w5ynbewh	360	10	-	-	HYPH
cord-289152-w5ynbewh	360	11	independent	independent	JJ
cord-289152-w5ynbewh	360	12	innate	innate	JJ
cord-289152-w5ynbewh	360	13	antiviral	antiviral	JJ
cord-289152-w5ynbewh	360	14	response	response	NN
cord-289152-w5ynbewh	360	15	against	against	IN
cord-289152-w5ynbewh	360	16	cytoplasmic	cytoplasmic	JJ
cord-289152-w5ynbewh	360	17	RNA	RNA	NNP
cord-289152-w5ynbewh	360	18	viruses	virus	NNS
cord-289152-w5ynbewh	360	19	NF	NF	NNP
cord-289152-w5ynbewh	360	20	-	-	HYPH
cord-289152-w5ynbewh	360	21	kappaB	kappaB	NNP
cord-289152-w5ynbewh	360	22	activation	activation	NN
cord-289152-w5ynbewh	360	23	upon	upon	IN
cord-289152-w5ynbewh	360	24	interaction	interaction	NN
cord-289152-w5ynbewh	360	25	of	of	IN
cord-289152-w5ynbewh	360	26	HIV-1	HIV-1	NNP
cord-289152-w5ynbewh	360	27	envelope	envelope	NN
cord-289152-w5ynbewh	360	28	glycoproteins	glycoprotein	NNS
cord-289152-w5ynbewh	360	29	with	with	IN
cord-289152-w5ynbewh	360	30	cell	cell	NN
cord-289152-w5ynbewh	360	31	surface	surface	NN
cord-289152-w5ynbewh	360	32	CD4	CD4	NNP
cord-289152-w5ynbewh	360	33	involves	involve	VBZ
cord-289152-w5ynbewh	360	34	IkappaB	IkappaB	NNP
cord-289152-w5ynbewh	360	35	kinases	kinase	NNS
cord-289152-w5ynbewh	360	36	Viral	viral	JJ
cord-289152-w5ynbewh	360	37	appropriation	appropriation	NN
cord-289152-w5ynbewh	360	38	of	of	IN
cord-289152-w5ynbewh	360	39	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	360	40	and	and	CC
cord-289152-w5ynbewh	360	41	NF	nf	NN
cord-289152-w5ynbewh	360	42	-	-	HYPH
cord-289152-w5ynbewh	360	43	kappaB	kappaB	NNP
cord-289152-w5ynbewh	360	44	signaling	signal	VBG
cord-289152-w5ynbewh	360	45	pathways	pathway	NNS
cord-289152-w5ynbewh	361	1	Control	Control	NNP
cord-289152-w5ynbewh	361	2	of	of	IN
cord-289152-w5ynbewh	361	3	I	I	NNP
cord-289152-w5ynbewh	361	4	kappa	kappa	NN
cord-289152-w5ynbewh	361	5	B	b	NN
cord-289152-w5ynbewh	361	6	-	-	HYPH
cord-289152-w5ynbewh	361	7	alpha	alpha	NN
cord-289152-w5ynbewh	361	8	proteolysis	proteolysis	NN
cord-289152-w5ynbewh	361	9	by	by	IN
cord-289152-w5ynbewh	361	10	site	site	NN
cord-289152-w5ynbewh	361	11	-	-	HYPH
cord-289152-w5ynbewh	361	12	specific	specific	JJ
cord-289152-w5ynbewh	361	13	,	,	,
cord-289152-w5ynbewh	361	14	signal	signal	NN
cord-289152-w5ynbewh	361	15	-	-	HYPH
cord-289152-w5ynbewh	361	16	induced	induce	VBN
cord-289152-w5ynbewh	361	17	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	361	18	NF	nf	NN
cord-289152-w5ynbewh	361	19	-	-	HYPH
cord-289152-w5ynbewh	361	20	kappaB	kappaB	NNP
cord-289152-w5ynbewh	361	21	family	family	NN
cord-289152-w5ynbewh	361	22	of	of	IN
cord-289152-w5ynbewh	361	23	transcription	transcription	NN
cord-289152-w5ynbewh	361	24	factors	factor	NNS
cord-289152-w5ynbewh	361	25	:	:	:
cord-289152-w5ynbewh	362	1	central	central	JJ
cord-289152-w5ynbewh	362	2	regulators	regulator	NNS
cord-289152-w5ynbewh	362	3	of	of	IN
cord-289152-w5ynbewh	362	4	innate	innate	JJ
cord-289152-w5ynbewh	362	5	and	and	CC
cord-289152-w5ynbewh	362	6	adaptive	adaptive	JJ
cord-289152-w5ynbewh	362	7	immune	immune	JJ
cord-289152-w5ynbewh	362	8	functions	function	NNS
cord-289152-w5ynbewh	362	9	Reovirus	Reovirus	NNP
cord-289152-w5ynbewh	362	10	-	-	HYPH
cord-289152-w5ynbewh	362	11	induced	induce	VBN
cord-289152-w5ynbewh	362	12	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	362	13	requires	require	VBZ
cord-289152-w5ynbewh	362	14	activation	activation	NN
cord-289152-w5ynbewh	362	15	of	of	IN
cord-289152-w5ynbewh	362	16	transcription	transcription	NN
cord-289152-w5ynbewh	362	17	factor	factor	NN
cord-289152-w5ynbewh	362	18	NF	NF	NNP
cord-289152-w5ynbewh	362	19	-	-	HYPH
cord-289152-w5ynbewh	362	20	kappaB	kappaB	NNP
cord-289152-w5ynbewh	362	21	Epstein	Epstein	NNP
cord-289152-w5ynbewh	362	22	-Barr	-Barr	NNP
cord-289152-w5ynbewh	362	23	virus	virus	NN
cord-289152-w5ynbewh	362	24	envelope	envelope	NN
cord-289152-w5ynbewh	362	25	glycoprotein	glycoprotein	VBG
cord-289152-w5ynbewh	362	26	gp350	gp350	NN
cord-289152-w5ynbewh	362	27	induces	induce	VBZ
cord-289152-w5ynbewh	362	28	NF	NF	NNP
cord-289152-w5ynbewh	362	29	-	-	HYPH
cord-289152-w5ynbewh	362	30	kappaB	kappaB	NNP
cord-289152-w5ynbewh	362	31	activation	activation	NN
cord-289152-w5ynbewh	362	32	and	and	CC
cord-289152-w5ynbewh	362	33	IL-1beta	il-1beta	JJ
cord-289152-w5ynbewh	362	34	synthesis	synthesis	NN
cord-289152-w5ynbewh	362	35	in	in	IN
cord-289152-w5ynbewh	362	36	human	human	JJ
cord-289152-w5ynbewh	362	37	monocytes	monocyte	NNS
cord-289152-w5ynbewh	362	38	-macrophages	-macrophage	NNS
cord-289152-w5ynbewh	362	39	involving	involve	VBG
cord-289152-w5ynbewh	362	40	PKC	PKC	NNP
cord-289152-w5ynbewh	362	41	and	and	CC
cord-289152-w5ynbewh	362	42	PI3-K	PI3-K	NNP
cord-289152-w5ynbewh	363	1	Basic	basic	JJ
cord-289152-w5ynbewh	363	2	Methods	Methods	NNPS
cord-289152-w5ynbewh	363	3	in	in	IN
cord-289152-w5ynbewh	363	4	Molecular	Molecular	NNP
cord-289152-w5ynbewh	363	5	Biology	Biology	NNP
cord-289152-w5ynbewh	363	6	Association	Association	NNP
cord-289152-w5ynbewh	363	7	of	of	IN
cord-289152-w5ynbewh	363	8	TRAF1	TRAF1	NNP
cord-289152-w5ynbewh	363	9	,	,	,
cord-289152-w5ynbewh	364	1	TRAF2	TRAF2	NNP
cord-289152-w5ynbewh	364	2	,	,	,
cord-289152-w5ynbewh	364	3	and	and	CC
cord-289152-w5ynbewh	364	4	TRAF3	traf3	NN
cord-289152-w5ynbewh	364	5	with	with	IN
cord-289152-w5ynbewh	364	6	an	an	DT
cord-289152-w5ynbewh	364	7	Epstein	Epstein	NNP
cord-289152-w5ynbewh	364	8	-Barr	-Barr	NNP
cord-289152-w5ynbewh	364	9	virus	virus	NN
cord-289152-w5ynbewh	364	10	LMP1	LMP1	NNP
cord-289152-w5ynbewh	364	11	domain	domain	NN
cord-289152-w5ynbewh	364	12	important	important	JJ
cord-289152-w5ynbewh	364	13	for	for	IN
cord-289152-w5ynbewh	364	14	Blymphocyte	Blymphocyte	NNP
cord-289152-w5ynbewh	364	15	transformation	transformation	NN
cord-289152-w5ynbewh	364	16	:	:	:
cord-289152-w5ynbewh	364	17	role	role	NN
cord-289152-w5ynbewh	364	18	in	in	IN
cord-289152-w5ynbewh	364	19	NF	NF	NNP
cord-289152-w5ynbewh	364	20	-	-	HYPH
cord-289152-w5ynbewh	364	21	kappaB	kappaB	NNP
cord-289152-w5ynbewh	364	22	activation	activation	NN
cord-289152-w5ynbewh	364	23	Failure	failure	NN
cord-289152-w5ynbewh	364	24	of	of	IN
cord-289152-w5ynbewh	364	25	measles	measle	NNS
cord-289152-w5ynbewh	364	26	virus	virus	NN
cord-289152-w5ynbewh	364	27	to	to	TO
cord-289152-w5ynbewh	364	28	activate	activate	VB
cord-289152-w5ynbewh	364	29	nuclear	nuclear	JJ
cord-289152-w5ynbewh	364	30	factor	factor	NN
cord-289152-w5ynbewh	364	31	-	-	HYPH
cord-289152-w5ynbewh	364	32	kappa	kappa	NN
cord-289152-w5ynbewh	364	33	B	b	NN
cord-289152-w5ynbewh	364	34	in	in	IN
cord-289152-w5ynbewh	364	35	neuronal	neuronal	JJ
cord-289152-w5ynbewh	364	36	cells	cell	NNS
cord-289152-w5ynbewh	364	37	:	:	:
cord-289152-w5ynbewh	364	38	implications	implication	NNS
cord-289152-w5ynbewh	364	39	on	on	IN
cord-289152-w5ynbewh	364	40	the	the	DT
cord-289152-w5ynbewh	364	41	immune	immune	JJ
cord-289152-w5ynbewh	364	42	response	response	NN
cord-289152-w5ynbewh	364	43	to	to	IN
cord-289152-w5ynbewh	364	44	viral	viral	JJ
cord-289152-w5ynbewh	364	45	infections	infection	NNS
cord-289152-w5ynbewh	364	46	in	in	IN
cord-289152-w5ynbewh	364	47	the	the	DT
cord-289152-w5ynbewh	364	48	central	central	JJ
cord-289152-w5ynbewh	364	49	nervous	nervous	JJ
cord-289152-w5ynbewh	364	50	system	system	NN
cord-289152-w5ynbewh	364	51	Porcine	porcine	JJ
cord-289152-w5ynbewh	364	52	reproductive	reproductive	JJ
cord-289152-w5ynbewh	364	53	and	and	CC
cord-289152-w5ynbewh	364	54	respiratory	respiratory	JJ
cord-289152-w5ynbewh	364	55	syndrome	syndrome	NN
cord-289152-w5ynbewh	364	56	:	:	:
cord-289152-w5ynbewh	364	57	clinical	clinical	JJ
cord-289152-w5ynbewh	364	58	disease	disease	NN
cord-289152-w5ynbewh	364	59	,	,	,
cord-289152-w5ynbewh	364	60	pathology	pathology	NN
cord-289152-w5ynbewh	364	61	and	and	CC
cord-289152-w5ynbewh	364	62	immunosuppression	immunosuppression	NN
cord-289152-w5ynbewh	364	63	Inactivation	Inactivation	NNP
cord-289152-w5ynbewh	364	64	of	of	IN
cord-289152-w5ynbewh	364	65	NF	NF	NNP
cord-289152-w5ynbewh	364	66	-	-	HYPH
cord-289152-w5ynbewh	364	67	kappaB	kappaB	NNP
cord-289152-w5ynbewh	364	68	by	by	IN
cord-289152-w5ynbewh	364	69	EBV	EBV	NNP
cord-289152-w5ynbewh	364	70	BZLF-1-encoded	BZLF-1-encoded	NNP
cord-289152-w5ynbewh	364	71	ZEBRA	ZEBRA	NNP
cord-289152-w5ynbewh	364	72	protein	protein	NN
cord-289152-w5ynbewh	364	73	in	in	IN
cord-289152-w5ynbewh	364	74	human	human	JJ
cord-289152-w5ynbewh	364	75	T	T	NNP
cord-289152-w5ynbewh	364	76	cells	cell	NNS
cord-289152-w5ynbewh	364	77	Mechanism	Mechanism	NNP
cord-289152-w5ynbewh	364	78	of	of	IN
cord-289152-w5ynbewh	364	79	measles	measle	NNS
cord-289152-w5ynbewh	364	80	virus	virus	NN
cord-289152-w5ynbewh	364	81	failure	failure	NN
cord-289152-w5ynbewh	364	82	to	to	TO
cord-289152-w5ynbewh	364	83	activate	activate	VB
cord-289152-w5ynbewh	364	84	NF	NF	NNP
cord-289152-w5ynbewh	364	85	-	-	HYPH
cord-289152-w5ynbewh	364	86	kappaB	kappaB	NNP
cord-289152-w5ynbewh	364	87	in	in	IN
cord-289152-w5ynbewh	364	88	neuronal	neuronal	JJ
cord-289152-w5ynbewh	364	89	cells	cell	NNS
cord-289152-w5ynbewh	364	90	Influenza	Influenza	NNP
cord-289152-w5ynbewh	364	91	virus	virus	NN
cord-289152-w5ynbewh	364	92	-	-	HYPH
cord-289152-w5ynbewh	364	93	induced	induce	VBN
cord-289152-w5ynbewh	364	94	NF	nf	NN
cord-289152-w5ynbewh	364	95	-	-	HYPH
cord-289152-w5ynbewh	364	96	kappaB	kappaB	NNP
cord-289152-w5ynbewh	364	97	-	-	HYPH
cord-289152-w5ynbewh	364	98	dependent	dependent	JJ
cord-289152-w5ynbewh	364	99	gene	gene	NN
cord-289152-w5ynbewh	364	100	expression	expression	NN
cord-289152-w5ynbewh	364	101	is	be	VBZ
cord-289152-w5ynbewh	364	102	mediated	mediate	VBN
cord-289152-w5ynbewh	364	103	by	by	IN
cord-289152-w5ynbewh	364	104	overexpression	overexpression	NN
cord-289152-w5ynbewh	364	105	of	of	IN
cord-289152-w5ynbewh	364	106	viral	viral	JJ
cord-289152-w5ynbewh	364	107	proteins	protein	NNS
cord-289152-w5ynbewh	364	108	and	and	CC
cord-289152-w5ynbewh	364	109	involves	involve	VBZ
cord-289152-w5ynbewh	364	110	oxidative	oxidative	JJ
cord-289152-w5ynbewh	364	111	radicals	radical	NNS
cord-289152-w5ynbewh	364	112	and	and	CC
cord-289152-w5ynbewh	364	113	activation	activation	NN
cord-289152-w5ynbewh	364	114	of	of	IN
cord-289152-w5ynbewh	364	115	IkappaB	IkappaB	NNP
cord-289152-w5ynbewh	364	116	kinase	kinase	CC
cord-289152-w5ynbewh	364	117	Interaction	Interaction	NNP
cord-289152-w5ynbewh	364	118	between	between	IN
cord-289152-w5ynbewh	364	119	Streptococcus	Streptococcus	NNP
cord-289152-w5ynbewh	364	120	suis	suis	NN
cord-289152-w5ynbewh	364	121	serotype	serotype	NN
cord-289152-w5ynbewh	364	122	2	2	CD
cord-289152-w5ynbewh	364	123	and	and	CC
cord-289152-w5ynbewh	364	124	porcine	porcine	JJ
cord-289152-w5ynbewh	364	125	reproductive	reproductive	JJ
cord-289152-w5ynbewh	364	126	and	and	CC
cord-289152-w5ynbewh	364	127	respiratory	respiratory	JJ
cord-289152-w5ynbewh	364	128	syndrome	syndrome	NN
cord-289152-w5ynbewh	364	129	virus	virus	NN
cord-289152-w5ynbewh	364	130	in	in	IN
cord-289152-w5ynbewh	364	131	specific	specific	JJ
cord-289152-w5ynbewh	364	132	pathogen	pathogen	NN
cord-289152-w5ynbewh	364	133	-	-	HYPH
cord-289152-w5ynbewh	364	134	free	free	JJ
cord-289152-w5ynbewh	364	135	piglets	piglet	NNS
cord-289152-w5ynbewh	365	1	Missing	miss	VBG
cord-289152-w5ynbewh	365	2	pieces	piece	NNS
cord-289152-w5ynbewh	365	3	in	in	IN
cord-289152-w5ynbewh	365	4	the	the	DT
cord-289152-w5ynbewh	365	5	NF	NF	NNP
cord-289152-w5ynbewh	365	6	-	-	HYPH
cord-289152-w5ynbewh	365	7	kappaB	kappaB	NNP
cord-289152-w5ynbewh	365	8	puzzle	puzzle	NN
cord-289152-w5ynbewh	365	9	NF	nf	NN
cord-289152-w5ynbewh	365	10	-	-	HYPH
cord-289152-w5ynbewh	365	11	kappa	kappa	NN
cord-289152-w5ynbewh	365	12	B	B	NNP
cord-289152-w5ynbewh	365	13	and	and	CC
cord-289152-w5ynbewh	365	14	Rel	Rel	NNP
cord-289152-w5ynbewh	365	15	proteins	protein	NNS
cord-289152-w5ynbewh	365	16	:	:	:
cord-289152-w5ynbewh	365	17	evolutionarily	evolutionarily	RB
cord-289152-w5ynbewh	365	18	conserved	conserved	JJ
cord-289152-w5ynbewh	365	19	mediators	mediator	NNS
cord-289152-w5ynbewh	365	20	of	of	IN
cord-289152-w5ynbewh	365	21	immune	immune	JJ
cord-289152-w5ynbewh	365	22	responses	response	NNS
cord-289152-w5ynbewh	366	1	Human	human	JJ
cord-289152-w5ynbewh	366	2	hepatitis	hepatitis	NN
cord-289152-w5ynbewh	366	3	C	C	NNP
cord-289152-w5ynbewh	366	4	virus	virus	NN
cord-289152-w5ynbewh	367	1	NS5A	NS5A	NNP
cord-289152-w5ynbewh	368	1	protein	protein	NN
cord-289152-w5ynbewh	368	2	alters	alter	VBZ
cord-289152-w5ynbewh	368	3	intracellular	intracellular	JJ
cord-289152-w5ynbewh	368	4	calcium	calcium	NN
cord-289152-w5ynbewh	368	5	levels	level	NNS
cord-289152-w5ynbewh	368	6	,	,	,
cord-289152-w5ynbewh	368	7	induces	induce	VBZ
cord-289152-w5ynbewh	368	8	oxidative	oxidative	JJ
cord-289152-w5ynbewh	368	9	stress	stress	NN
cord-289152-w5ynbewh	368	10	,	,	,
cord-289152-w5ynbewh	368	11	and	and	CC
cord-289152-w5ynbewh	368	12	activates	activate	VBZ
cord-289152-w5ynbewh	368	13	STAT-3	STAT-3	NNP
cord-289152-w5ynbewh	368	14	and	and	CC
cord-289152-w5ynbewh	368	15	NF	nf	NN
cord-289152-w5ynbewh	368	16	-	-	HYPH
cord-289152-w5ynbewh	368	17	kappa	kappa	NN
cord-289152-w5ynbewh	368	18	B	B	NNP
cord-289152-w5ynbewh	368	19	NF	NF	NNP
cord-289152-w5ynbewh	368	20	-	-	HYPH
cord-289152-w5ynbewh	368	21	kappaB	kappaB	NNP
cord-289152-w5ynbewh	368	22	is	be	VBZ
cord-289152-w5ynbewh	368	23	required	require	VBN
cord-289152-w5ynbewh	368	24	for	for	IN
cord-289152-w5ynbewh	368	25	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	368	26	prevention	prevention	NN
cord-289152-w5ynbewh	368	27	during	during	IN
cord-289152-w5ynbewh	368	28	herpes	herpes	NNP
cord-289152-w5ynbewh	368	29	simplex	simplex	NNP
cord-289152-w5ynbewh	368	30	virus	virus	NN
cord-289152-w5ynbewh	368	31	type	type	NN
cord-289152-w5ynbewh	368	32	1	1	CD
cord-289152-w5ynbewh	368	33	infection	infection	NN
cord-289152-w5ynbewh	368	34	Efficient	efficient	JJ
cord-289152-w5ynbewh	368	35	replication	replication	NN
cord-289152-w5ynbewh	368	36	by	by	IN
cord-289152-w5ynbewh	368	37	herpes	herpes	NNP
cord-289152-w5ynbewh	368	38	simplex	simplex	NNP
cord-289152-w5ynbewh	368	39	virus	virus	NN
cord-289152-w5ynbewh	368	40	type	type	NN
cord-289152-w5ynbewh	368	41	1	1	CD
cord-289152-w5ynbewh	368	42	involves	involve	VBZ
cord-289152-w5ynbewh	368	43	activation	activation	NN
cord-289152-w5ynbewh	368	44	of	of	IN
cord-289152-w5ynbewh	368	45	the	the	DT
cord-289152-w5ynbewh	368	46	IkappaB	IkappaB	NNP
cord-289152-w5ynbewh	368	47	kinase	kinase	NN
cord-289152-w5ynbewh	368	48	-	-	HYPH
cord-289152-w5ynbewh	368	49	IkappaB	IkappaB	NNP
cord-289152-w5ynbewh	368	50	-	-	HYPH
cord-289152-w5ynbewh	368	51	p65	p65	NN
cord-289152-w5ynbewh	368	52	pathway	pathway	NN
cord-289152-w5ynbewh	368	53	EBV	EBV	NNP
cord-289152-w5ynbewh	368	54	latent	latent	NN
cord-289152-w5ynbewh	368	55	membrane	membrane	NN
cord-289152-w5ynbewh	368	56	protein-1	protein-1	NNP
cord-289152-w5ynbewh	368	57	protects	protect	VBZ
cord-289152-w5ynbewh	368	58	B	b	NN
cord-289152-w5ynbewh	368	59	-	-	HYPH
cord-289152-w5ynbewh	368	60	cells	cell	NNS
cord-289152-w5ynbewh	368	61	from	from	IN
cord-289152-w5ynbewh	368	62	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	368	63	by	by	IN
cord-289152-w5ynbewh	368	64	inhibition	inhibition	NN
cord-289152-w5ynbewh	368	65	of	of	IN
cord-289152-w5ynbewh	368	66	bax	bax	NNP
cord-289152-w5ynbewh	368	67	Serological	Serological	NNP
cord-289152-w5ynbewh	368	68	studies	study	NNS
cord-289152-w5ynbewh	368	69	on	on	IN
cord-289152-w5ynbewh	368	70	the	the	DT
cord-289152-w5ynbewh	368	71	potential	potential	JJ
cord-289152-w5ynbewh	368	72	synergism	synergism	NN
cord-289152-w5ynbewh	368	73	of	of	IN
cord-289152-w5ynbewh	368	74	porcine	porcine	JJ
cord-289152-w5ynbewh	368	75	reproductive	reproductive	JJ
cord-289152-w5ynbewh	368	76	and	and	CC
cord-289152-w5ynbewh	368	77	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	78	syndrome	syndrome	NN
cord-289152-w5ynbewh	368	79	virus	virus	NN
cord-289152-w5ynbewh	368	80	and	and	CC
cord-289152-w5ynbewh	368	81	influenza-	influenza-	NNP
cord-289152-w5ynbewh	368	82	,	,	,
cord-289152-w5ynbewh	368	83	corona	corona	NN
cord-289152-w5ynbewh	368	84	-	-	HYPH
cord-289152-w5ynbewh	368	85	and	and	CC
cord-289152-w5ynbewh	368	86	paramyxoviruses	paramyxovirus	NNS
cord-289152-w5ynbewh	368	87	in	in	IN
cord-289152-w5ynbewh	368	88	the	the	DT
cord-289152-w5ynbewh	368	89	induction	induction	NN
cord-289152-w5ynbewh	368	90	of	of	IN
cord-289152-w5ynbewh	368	91	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	92	symptoms	symptom	NNS
cord-289152-w5ynbewh	368	93	in	in	IN
cord-289152-w5ynbewh	368	94	swine	swine	NN
cord-289152-w5ynbewh	368	95	Comparison	comparison	NN
cord-289152-w5ynbewh	368	96	of	of	IN
cord-289152-w5ynbewh	368	97	the	the	DT
cord-289152-w5ynbewh	368	98	pathogenicity	pathogenicity	NN
cord-289152-w5ynbewh	368	99	of	of	IN
cord-289152-w5ynbewh	368	100	two	two	CD
cord-289152-w5ynbewh	368	101	US	US	NNP
cord-289152-w5ynbewh	368	102	porcine	porcine	JJ
cord-289152-w5ynbewh	368	103	reproductive	reproductive	JJ
cord-289152-w5ynbewh	368	104	and	and	CC
cord-289152-w5ynbewh	368	105	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	106	syndrome	syndrome	NN
cord-289152-w5ynbewh	368	107	virus	virus	NN
cord-289152-w5ynbewh	368	108	isolates	isolate	VBZ
cord-289152-w5ynbewh	368	109	with	with	IN
cord-289152-w5ynbewh	368	110	that	that	DT
cord-289152-w5ynbewh	368	111	of	of	IN
cord-289152-w5ynbewh	368	112	the	the	DT
cord-289152-w5ynbewh	368	113	Lelystad	Lelystad	NNP
cord-289152-w5ynbewh	368	114	virus	virus	NN
cord-289152-w5ynbewh	368	115	Signaling	signal	VBG
cord-289152-w5ynbewh	368	116	to	to	IN
cord-289152-w5ynbewh	368	117	NF	NF	NNP
cord-289152-w5ynbewh	368	118	-	-	HYPH
cord-289152-w5ynbewh	368	119	kappaB	kappaB	NNP
cord-289152-w5ynbewh	368	120	Measles	Measles	NNP
cord-289152-w5ynbewh	368	121	virus	virus	NN
cord-289152-w5ynbewh	368	122	activates	activate	VBZ
cord-289152-w5ynbewh	368	123	NF	nf	NN
cord-289152-w5ynbewh	368	124	-	-	HYPH
cord-289152-w5ynbewh	368	125	kappa	kappa	NN
cord-289152-w5ynbewh	368	126	B	b	NN
cord-289152-w5ynbewh	368	127	and	and	CC
cord-289152-w5ynbewh	368	128	STAT	stat	NN
cord-289152-w5ynbewh	368	129	transcription	transcription	NN
cord-289152-w5ynbewh	368	130	factors	factor	NNS
cord-289152-w5ynbewh	368	131	and	and	CC
cord-289152-w5ynbewh	368	132	production	production	NN
cord-289152-w5ynbewh	368	133	of	of	IN
cord-289152-w5ynbewh	368	134	IFN	IFN	NNP
cord-289152-w5ynbewh	368	135	-	-	HYPH
cord-289152-w5ynbewh	368	136	alpha	alpha	NN
cord-289152-w5ynbewh	368	137	/	/	SYM
cord-289152-w5ynbewh	368	138	beta	beta	NN
cord-289152-w5ynbewh	368	139	and	and	CC
cord-289152-w5ynbewh	368	140	IL-6	IL-6	NNP
cord-289152-w5ynbewh	368	141	in	in	IN
cord-289152-w5ynbewh	368	142	the	the	DT
cord-289152-w5ynbewh	368	143	human	human	JJ
cord-289152-w5ynbewh	368	144	lung	lung	NN
cord-289152-w5ynbewh	368	145	epithelial	epithelial	JJ
cord-289152-w5ynbewh	368	146	cell	cell	NN
cord-289152-w5ynbewh	368	147	line	line	NN
cord-289152-w5ynbewh	368	148	A549	A549	NNP
cord-289152-w5ynbewh	368	149	Convergence	Convergence	NNP
cord-289152-w5ynbewh	368	150	of	of	IN
cord-289152-w5ynbewh	368	151	the	the	DT
cord-289152-w5ynbewh	368	152	NF	NF	NNP
cord-289152-w5ynbewh	368	153	-	-	HYPH
cord-289152-w5ynbewh	368	154	kappaB	kappaB	NNP
cord-289152-w5ynbewh	368	155	and	and	CC
cord-289152-w5ynbewh	368	156	interferon	interferon	NN
cord-289152-w5ynbewh	368	157	signaling	signal	VBG
cord-289152-w5ynbewh	368	158	pathways	pathway	NNS
cord-289152-w5ynbewh	368	159	in	in	IN
cord-289152-w5ynbewh	368	160	the	the	DT
cord-289152-w5ynbewh	368	161	regulation	regulation	NN
cord-289152-w5ynbewh	368	162	of	of	IN
cord-289152-w5ynbewh	368	163	antiviral	antiviral	JJ
cord-289152-w5ynbewh	368	164	defense	defense	NN
cord-289152-w5ynbewh	368	165	and	and	CC
cord-289152-w5ynbewh	368	166	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	368	167	Characterization	characterization	NN
cord-289152-w5ynbewh	368	168	of	of	IN
cord-289152-w5ynbewh	368	169	the	the	DT
cord-289152-w5ynbewh	368	170	carrier	carrier	NN
cord-289152-w5ynbewh	368	171	state	state	NN
cord-289152-w5ynbewh	368	172	in	in	IN
cord-289152-w5ynbewh	368	173	porcine	porcine	JJ
cord-289152-w5ynbewh	368	174	reproductive	reproductive	JJ
cord-289152-w5ynbewh	368	175	and	and	CC
cord-289152-w5ynbewh	368	176	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	177	syndrome	syndrome	NN
cord-289152-w5ynbewh	368	178	virus	virus	NN
cord-289152-w5ynbewh	368	179	infection	infection	NN
cord-289152-w5ynbewh	368	180	Oxidative	oxidative	JJ
cord-289152-w5ynbewh	368	181	stress	stress	NN
cord-289152-w5ynbewh	368	182	in	in	IN
cord-289152-w5ynbewh	368	183	human	human	JJ
cord-289152-w5ynbewh	368	184	immunodeficiency	immunodeficiency	NN
cord-289152-w5ynbewh	368	185	virus	virus	NN
cord-289152-w5ynbewh	368	186	infection	infection	NN
cord-289152-w5ynbewh	368	187	Potential	potential	JJ
cord-289152-w5ynbewh	368	188	dengue	dengue	NN
cord-289152-w5ynbewh	368	189	virus	virus	NN
cord-289152-w5ynbewh	368	190	-	-	HYPH
cord-289152-w5ynbewh	368	191	triggered	trigger	VBN
cord-289152-w5ynbewh	368	192	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	368	193	pathway	pathway	NN
cord-289152-w5ynbewh	368	194	in	in	IN
cord-289152-w5ynbewh	368	195	human	human	JJ
cord-289152-w5ynbewh	368	196	neuroblastoma	neuroblastoma	NN
cord-289152-w5ynbewh	368	197	cells	cell	NNS
cord-289152-w5ynbewh	368	198	:	:	:
cord-289152-w5ynbewh	368	199	arachidonic	arachidonic	JJ
cord-289152-w5ynbewh	368	200	acid	acid	NN
cord-289152-w5ynbewh	368	201	,	,	,
cord-289152-w5ynbewh	368	202	superoxide	superoxide	NN
cord-289152-w5ynbewh	368	203	anion	anion	NN
cord-289152-w5ynbewh	368	204	,	,	,
cord-289152-w5ynbewh	368	205	and	and	CC
cord-289152-w5ynbewh	368	206	NF	NF	NNP
cord-289152-w5ynbewh	368	207	-	-	HYPH
cord-289152-w5ynbewh	368	208	kappaB	kappaB	NNP
cord-289152-w5ynbewh	368	209	are	be	VBP
cord-289152-w5ynbewh	368	210	sequentially	sequentially	RB
cord-289152-w5ynbewh	368	211	involved	involve	VBN
cord-289152-w5ynbewh	368	212	Recent	recent	JJ
cord-289152-w5ynbewh	368	213	advances	advance	NNS
cord-289152-w5ynbewh	368	214	towards	towards	IN
cord-289152-w5ynbewh	368	215	understanding	understand	VBG
cord-289152-w5ynbewh	368	216	redox	redox	NN
cord-289152-w5ynbewh	368	217	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	368	218	in	in	IN
cord-289152-w5ynbewh	368	219	the	the	DT
cord-289152-w5ynbewh	368	220	activation	activation	NN
cord-289152-w5ynbewh	368	221	of	of	IN
cord-289152-w5ynbewh	368	222	nuclear	nuclear	JJ
cord-289152-w5ynbewh	368	223	factor	factor	NN
cord-289152-w5ynbewh	368	224	kappaB	kappaB	NNP
cord-289152-w5ynbewh	368	225	Detection	Detection	NNP
cord-289152-w5ynbewh	368	226	of	of	IN
cord-289152-w5ynbewh	368	227	porcine	porcine	JJ
cord-289152-w5ynbewh	368	228	reproductive	reproductive	JJ
cord-289152-w5ynbewh	368	229	and	and	CC
cord-289152-w5ynbewh	368	230	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	231	syndrome	syndrome	NN
cord-289152-w5ynbewh	368	232	virus	virus	NN
cord-289152-w5ynbewh	368	233	and	and	CC
cord-289152-w5ynbewh	368	234	Mycoplasma	Mycoplasma	NNP
cord-289152-w5ynbewh	368	235	hyorhinis	hyorhinis	NNP
cord-289152-w5ynbewh	368	236	antigens	antigen	NNS
cord-289152-w5ynbewh	368	237	in	in	IN
cord-289152-w5ynbewh	368	238	pulmonary	pulmonary	JJ
cord-289152-w5ynbewh	368	239	lesions	lesion	NNS
cord-289152-w5ynbewh	368	240	of	of	IN
cord-289152-w5ynbewh	368	241	pigs	pig	NNS
cord-289152-w5ynbewh	368	242	suffering	suffer	VBG
cord-289152-w5ynbewh	368	243	from	from	IN
cord-289152-w5ynbewh	368	244	respiratory	respiratory	JJ
cord-289152-w5ynbewh	368	245	distress	distress	NN
cord-289152-w5ynbewh	369	1	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-289152-w5ynbewh	369	2	activates	activate	VBZ
cord-289152-w5ynbewh	369	3	matrix	matrix	NN
cord-289152-w5ynbewh	369	4	metalloproteinase-2	metalloproteinase-2	NNP
cord-289152-w5ynbewh	369	5	in	in	IN
cord-289152-w5ynbewh	369	6	endothelial	endothelial	JJ
cord-289152-w5ynbewh	369	7	cells	cell	NNS
cord-289152-w5ynbewh	369	8	through	through	IN
cord-289152-w5ynbewh	369	9	an	an	DT
cord-289152-w5ynbewh	369	10	NF	nf	NN
cord-289152-w5ynbewh	369	11	-	-	HYPH
cord-289152-w5ynbewh	369	12	kappaB	kappaB	NNP
cord-289152-w5ynbewh	369	13	-	-	HYPH
cord-289152-w5ynbewh	369	14	dependent	dependent	JJ
cord-289152-w5ynbewh	369	15	pathway	pathway	NN
cord-289152-w5ynbewh	369	16	Enhanced	enhance	VBN
cord-289152-w5ynbewh	369	17	replication	replication	NN
cord-289152-w5ynbewh	369	18	of	of	IN
cord-289152-w5ynbewh	369	19	porcine	porcine	JJ
cord-289152-w5ynbewh	369	20	reproductive	reproductive	JJ
cord-289152-w5ynbewh	369	21	and	and	CC
cord-289152-w5ynbewh	369	22	respiratory	respiratory	JJ
cord-289152-w5ynbewh	369	23	syndrome	syndrome	NN
cord-289152-w5ynbewh	369	24	(	(	-LRB-
cord-289152-w5ynbewh	369	25	PRRS	PRRS	NNP
cord-289152-w5ynbewh	369	26	)	)	-RRB-
cord-289152-w5ynbewh	369	27	virus	virus	NN
cord-289152-w5ynbewh	369	28	in	in	IN
cord-289152-w5ynbewh	369	29	a	a	DT
cord-289152-w5ynbewh	369	30	homogeneous	homogeneous	JJ
cord-289152-w5ynbewh	369	31	subpopulation	subpopulation	NN
cord-289152-w5ynbewh	369	32	of	of	IN
cord-289152-w5ynbewh	369	33	MA-104	MA-104	NNP
cord-289152-w5ynbewh	369	34	cell	cell	NN
cord-289152-w5ynbewh	369	35	line	line	NN
cord-289152-w5ynbewh	369	36	Signaling	signal	VBG
cord-289152-w5ynbewh	369	37	pathways	pathway	NNS
cord-289152-w5ynbewh	369	38	to	to	IN
cord-289152-w5ynbewh	369	39	the	the	DT
cord-289152-w5ynbewh	369	40	assembly	assembly	NN
cord-289152-w5ynbewh	369	41	of	of	IN
cord-289152-w5ynbewh	369	42	an	an	DT
cord-289152-w5ynbewh	369	43	interferon	interferon	NN
cord-289152-w5ynbewh	369	44	-	-	HYPH
cord-289152-w5ynbewh	369	45	beta	beta	NN
cord-289152-w5ynbewh	369	46	enhanceosome	enhanceosome	NN
cord-289152-w5ynbewh	369	47	.	.	.
cord-289152-w5ynbewh	370	1	Chemical	chemical	JJ
cord-289152-w5ynbewh	370	2	genetic	genetic	JJ
cord-289152-w5ynbewh	370	3	studies	study	NNS
cord-289152-w5ynbewh	370	4	with	with	IN
cord-289152-w5ynbewh	370	5	a	a	DT
cord-289152-w5ynbewh	370	6	small	small	JJ
cord-289152-w5ynbewh	370	7	molecule	molecule	NN
cord-289152-w5ynbewh	370	8	Applications	application	NNS
cord-289152-w5ynbewh	370	9	of	of	IN
cord-289152-w5ynbewh	370	10	competitor	competitor	NN
cord-289152-w5ynbewh	370	11	RNA	RNA	NNP
cord-289152-w5ynbewh	370	12	in	in	IN
cord-289152-w5ynbewh	370	13	diagnostic	diagnostic	JJ
cord-289152-w5ynbewh	370	14	reverse	reverse	JJ
cord-289152-w5ynbewh	370	15	transcription	transcription	NN
cord-289152-w5ynbewh	370	16	-	-	HYPH
cord-289152-w5ynbewh	370	17	PCR	PCR	NNP
cord-289152-w5ynbewh	370	18	Inhibition	inhibition	NN
cord-289152-w5ynbewh	370	19	of	of	IN
cord-289152-w5ynbewh	370	20	matrix	matrix	NN
cord-289152-w5ynbewh	370	21	metalloproteinases	metalloproteinase	NNS
cord-289152-w5ynbewh	370	22	prevents	prevent	VBZ
cord-289152-w5ynbewh	370	23	allergen	allergen	NN
cord-289152-w5ynbewh	370	24	-	-	HYPH
cord-289152-w5ynbewh	370	25	induced	induce	VBN
cord-289152-w5ynbewh	370	26	airway	airway	JJ
cord-289152-w5ynbewh	370	27	inflammation	inflammation	NN
cord-289152-w5ynbewh	370	28	in	in	IN
cord-289152-w5ynbewh	370	29	a	a	DT
cord-289152-w5ynbewh	370	30	murine	murine	JJ
cord-289152-w5ynbewh	370	31	model	model	NN
cord-289152-w5ynbewh	370	32	of	of	IN
cord-289152-w5ynbewh	370	33	asthma	asthma	NN
cord-289152-w5ynbewh	370	34	Porcine	porcine	JJ
cord-289152-w5ynbewh	370	35	reproductive	reproductive	JJ
cord-289152-w5ynbewh	370	36	and	and	CC
cord-289152-w5ynbewh	370	37	respiratory	respiratory	JJ
cord-289152-w5ynbewh	370	38	syndrome	syndrome	NN
cord-289152-w5ynbewh	370	39	virus	virus	NN
cord-289152-w5ynbewh	370	40	field	field	NN
cord-289152-w5ynbewh	370	41	isolates	isolate	NNS
cord-289152-w5ynbewh	370	42	differ	differ	VBP
cord-289152-w5ynbewh	370	43	in	in	IN
cord-289152-w5ynbewh	370	44	in	in	FW
cord-289152-w5ynbewh	370	45	vitro	vitro	FW
cord-289152-w5ynbewh	370	46	interferon	interferon	NN
cord-289152-w5ynbewh	370	47	phenotypes	phenotype	NNS
cord-289152-w5ynbewh	371	1	The	the	DT
cord-289152-w5ynbewh	371	2	involvement	involvement	NN
cord-289152-w5ynbewh	371	3	of	of	IN
cord-289152-w5ynbewh	371	4	NF	nf	NN
cord-289152-w5ynbewh	371	5	-	-	HYPH
cord-289152-w5ynbewh	371	6	kappa	kappa	NN
cord-289152-w5ynbewh	371	7	B	b	NN
cord-289152-w5ynbewh	371	8	in	in	IN
cord-289152-w5ynbewh	371	9	beta	beta	NN
cord-289152-w5ynbewh	371	10	-	-	HYPH
cord-289152-w5ynbewh	371	11	interferon	interferon	NN
cord-289152-w5ynbewh	371	12	gene	gene	NN
cord-289152-w5ynbewh	371	13	regulation	regulation	NN
cord-289152-w5ynbewh	371	14	reveals	reveal	VBZ
cord-289152-w5ynbewh	371	15	its	-PRON-	PRP$
cord-289152-w5ynbewh	371	16	role	role	NN
cord-289152-w5ynbewh	371	17	as	as	RB
cord-289152-w5ynbewh	371	18	widely	widely	RB
cord-289152-w5ynbewh	371	19	inducible	inducible	JJ
cord-289152-w5ynbewh	371	20	mediator	mediator	NN
cord-289152-w5ynbewh	371	21	of	of	IN
cord-289152-w5ynbewh	371	22	signal	signal	NN
cord-289152-w5ynbewh	371	23	transduction	transduction	NN
cord-289152-w5ynbewh	371	24	NF	nf	NN
cord-289152-w5ynbewh	371	25	-	-	HYPH
cord-289152-w5ynbewh	371	26	kappaB	kappaB	NNP
cord-289152-w5ynbewh	371	27	regulation	regulation	NN
cord-289152-w5ynbewh	371	28	in	in	IN
cord-289152-w5ynbewh	371	29	the	the	DT
cord-289152-w5ynbewh	371	30	immune	immune	JJ
cord-289152-w5ynbewh	371	31	system	system	NN
cord-289152-w5ynbewh	372	1	Salicylates	salicylate	NNS
cord-289152-w5ynbewh	372	2	inhibit	inhibit	VBP
cord-289152-w5ynbewh	372	3	flavivirus	flavivirus	JJ
cord-289152-w5ynbewh	372	4	replication	replication	NN
cord-289152-w5ynbewh	372	5	independently	independently	RB
cord-289152-w5ynbewh	372	6	of	of	IN
cord-289152-w5ynbewh	372	7	blocking	block	VBG
cord-289152-w5ynbewh	372	8	nuclear	nuclear	JJ
cord-289152-w5ynbewh	372	9	factor	factor	NN
cord-289152-w5ynbewh	372	10	kappa	kappa	NNP
cord-289152-w5ynbewh	372	11	B	B	NNP
cord-289152-w5ynbewh	372	12	activation	activation	NN
cord-289152-w5ynbewh	372	13	Thiol	Thiol	NNP
cord-289152-w5ynbewh	372	14	agents	agent	NNS
cord-289152-w5ynbewh	372	15	and	and	CC
cord-289152-w5ynbewh	372	16	Bcl-2	Bcl-2	NNP
cord-289152-w5ynbewh	372	17	identify	identify	VB
cord-289152-w5ynbewh	372	18	an	an	DT
cord-289152-w5ynbewh	372	19	alphavirus	alphavirus	NN
cord-289152-w5ynbewh	372	20	-	-	HYPH
cord-289152-w5ynbewh	372	21	induced	induce	VBN
cord-289152-w5ynbewh	372	22	apoptotic	apoptotic	JJ
cord-289152-w5ynbewh	372	23	pathway	pathway	NN
cord-289152-w5ynbewh	372	24	that	that	WDT
cord-289152-w5ynbewh	372	25	requires	require	VBZ
cord-289152-w5ynbewh	372	26	activation	activation	NN
cord-289152-w5ynbewh	372	27	of	of	IN
cord-289152-w5ynbewh	372	28	the	the	DT
cord-289152-w5ynbewh	372	29	transcription	transcription	NN
cord-289152-w5ynbewh	372	30	factor	factor	NN
cord-289152-w5ynbewh	372	31	NF	nf	NN
cord-289152-w5ynbewh	372	32	-	-	HYPH
cord-289152-w5ynbewh	372	33	kappa	kappa	NN
cord-289152-w5ynbewh	372	34	B	B	NNP
cord-289152-w5ynbewh	372	35	Suppression	Suppression	NNP
cord-289152-w5ynbewh	372	36	of	of	IN
cord-289152-w5ynbewh	372	37	steady	steady	JJ
cord-289152-w5ynbewh	372	38	-	-	HYPH
cord-289152-w5ynbewh	372	39	state	state	NN
cord-289152-w5ynbewh	372	40	,	,	,
cord-289152-w5ynbewh	372	41	but	but	CC
cord-289152-w5ynbewh	373	1	not	not	RB
cord-289152-w5ynbewh	373	2	stimulus	stimulus	NN
cord-289152-w5ynbewh	373	3	-	-	HYPH
cord-289152-w5ynbewh	373	4	induced	induce	VBN
cord-289152-w5ynbewh	373	5	NF	nf	NN
cord-289152-w5ynbewh	373	6	-	-	HYPH
cord-289152-w5ynbewh	373	7	kappaB	kappaB	NNP
cord-289152-w5ynbewh	373	8	activity	activity	NN
cord-289152-w5ynbewh	373	9	inhibits	inhibit	VBZ
cord-289152-w5ynbewh	374	1	alphavirus	alphavirus	NNP
cord-289152-w5ynbewh	374	2	-	-	HYPH
cord-289152-w5ynbewh	374	3	induced	induce	VBN
cord-289152-w5ynbewh	374	4	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	374	5	Replication	replication	NN
cord-289152-w5ynbewh	374	6	-	-	HYPH
cord-289152-w5ynbewh	374	7	incompetent	incompetent	JJ
cord-289152-w5ynbewh	374	8	virions	virion	NNS
cord-289152-w5ynbewh	374	9	of	of	IN
cord-289152-w5ynbewh	374	10	Japanese	japanese	JJ
cord-289152-w5ynbewh	374	11	encephalitis	encephalitis	RB
cord-289152-w5ynbewh	374	12	virus	virus	NN
cord-289152-w5ynbewh	374	13	trigger	trigger	VBP
cord-289152-w5ynbewh	374	14	neuronal	neuronal	JJ
cord-289152-w5ynbewh	374	15	cell	cell	NN
cord-289152-w5ynbewh	374	16	death	death	NN
cord-289152-w5ynbewh	374	17	by	by	IN
cord-289152-w5ynbewh	374	18	oxidative	oxidative	JJ
cord-289152-w5ynbewh	374	19	stress	stress	NN
cord-289152-w5ynbewh	374	20	in	in	IN
cord-289152-w5ynbewh	374	21	a	a	DT
cord-289152-w5ynbewh	374	22	culture	culture	NN
cord-289152-w5ynbewh	374	23	system	system	NN
cord-289152-w5ynbewh	374	24	Signal	Signal	NNP
cord-289152-w5ynbewh	374	25	transduction	transduction	NN
cord-289152-w5ynbewh	374	26	through	through	IN
cord-289152-w5ynbewh	374	27	NF	nf	NN
cord-289152-w5ynbewh	374	28	-	-	HYPH
cord-289152-w5ynbewh	374	29	kappa	kappa	NN
cord-289152-w5ynbewh	374	30	B	B	NNP
cord-289152-w5ynbewh	374	31	Gradual	gradual	JJ
cord-289152-w5ynbewh	374	32	development	development	NN
cord-289152-w5ynbewh	374	33	of	of	IN
cord-289152-w5ynbewh	374	34	the	the	DT
cord-289152-w5ynbewh	374	35	interferon	interferon	NN
cord-289152-w5ynbewh	374	36	-	-	HYPH
cord-289152-w5ynbewh	374	37	gamma	gamma	NN
cord-289152-w5ynbewh	374	38	response	response	NN
cord-289152-w5ynbewh	374	39	of	of	IN
cord-289152-w5ynbewh	374	40	swine	swine	NN
cord-289152-w5ynbewh	374	41	to	to	IN
cord-289152-w5ynbewh	374	42	porcine	porcine	JJ
cord-289152-w5ynbewh	374	43	reproductive	reproductive	JJ
cord-289152-w5ynbewh	374	44	and	and	CC
cord-289152-w5ynbewh	374	45	respiratory	respiratory	JJ
cord-289152-w5ynbewh	374	46	syndrome	syndrome	NN
cord-289152-w5ynbewh	374	47	virus	virus	NN
cord-289152-w5ynbewh	374	48	infection	infection	NN
cord-289152-w5ynbewh	374	49	or	or	CC
cord-289152-w5ynbewh	375	1	vaccination	vaccination	NN
cord-289152-w5ynbewh	375	2	Induced	induce	VBN
cord-289152-w5ynbewh	375	3	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	375	4	supports	support	VBZ
cord-289152-w5ynbewh	375	5	spread	spread	NN
cord-289152-w5ynbewh	375	6	of	of	IN
cord-289152-w5ynbewh	375	7	adenovirus	adenovirus	NN
cord-289152-w5ynbewh	375	8	vectors	vector	NNS
cord-289152-w5ynbewh	375	9	in	in	IN
cord-289152-w5ynbewh	375	10	tumors	tumor	NNS
cord-289152-w5ynbewh	375	11	.	.	.
cord-289152-w5ynbewh	376	1	Hum	Hum	NNP
cord-289152-w5ynbewh	377	1	Interferon	interferon	NN
cord-289152-w5ynbewh	377	2	type	type	NN
cord-289152-w5ynbewh	378	1	I	-PRON-	PRP
cord-289152-w5ynbewh	378	2	response	response	VBP
cord-289152-w5ynbewh	378	3	in	in	IN
cord-289152-w5ynbewh	378	4	porcine	porcine	JJ
cord-289152-w5ynbewh	378	5	reproductive	reproductive	JJ
cord-289152-w5ynbewh	378	6	and	and	CC
cord-289152-w5ynbewh	378	7	respiratory	respiratory	JJ
cord-289152-w5ynbewh	378	8	syndrome	syndrome	NN
cord-289152-w5ynbewh	378	9	virus	virus	NN
cord-289152-w5ynbewh	378	10	-	-	HYPH
cord-289152-w5ynbewh	378	11	infected	infect	VBN
cord-289152-w5ynbewh	378	12	MARC-145	MARC-145	NNP
cord-289152-w5ynbewh	378	13	cells	cell	NNS
cord-289152-w5ynbewh	379	1	Molecular	molecular	JJ
cord-289152-w5ynbewh	379	2	pathways	pathway	NNS
cord-289152-w5ynbewh	379	3	in	in	IN
cord-289152-w5ynbewh	379	4	virus	virus	NN
cord-289152-w5ynbewh	379	5	-	-	HYPH
cord-289152-w5ynbewh	379	6	induced	induce	VBN
cord-289152-w5ynbewh	379	7	cytokine	cytokine	NN
cord-289152-w5ynbewh	379	8	production	production	NN
cord-289152-w5ynbewh	379	9	.	.	.
cord-289152-w5ynbewh	380	1	Microbiol	Microbiol	NNP
cord-289152-w5ynbewh	380	2	Activation	Activation	NNP
cord-289152-w5ynbewh	380	3	of	of	IN
cord-289152-w5ynbewh	380	4	NF	nf	NN
cord-289152-w5ynbewh	380	5	-	-	HYPH
cord-289152-w5ynbewh	380	6	kappa	kappa	NN
cord-289152-w5ynbewh	380	7	B	b	NN
cord-289152-w5ynbewh	380	8	in	in	IN
cord-289152-w5ynbewh	380	9	virus	virus	NN
cord-289152-w5ynbewh	380	10	-	-	HYPH
cord-289152-w5ynbewh	380	11	infected	infect	VBN
cord-289152-w5ynbewh	380	12	macrophages	macrophage	NNS
cord-289152-w5ynbewh	380	13	is	be	VBZ
cord-289152-w5ynbewh	380	14	dependent	dependent	JJ
cord-289152-w5ynbewh	380	15	on	on	IN
cord-289152-w5ynbewh	380	16	mitochondrial	mitochondrial	JJ
cord-289152-w5ynbewh	380	17	oxidative	oxidative	JJ
cord-289152-w5ynbewh	380	18	stress	stress	NN
cord-289152-w5ynbewh	380	19	and	and	CC
cord-289152-w5ynbewh	380	20	intracellular	intracellular	JJ
cord-289152-w5ynbewh	380	21	calcium	calcium	NN
cord-289152-w5ynbewh	380	22	:	:	:
cord-289152-w5ynbewh	380	23	downstream	downstream	JJ
cord-289152-w5ynbewh	380	24	involvement	involvement	NN
cord-289152-w5ynbewh	380	25	of	of	IN
cord-289152-w5ynbewh	380	26	the	the	DT
cord-289152-w5ynbewh	380	27	kinases	kinase	NNS
cord-289152-w5ynbewh	380	28	TGF	TGF	NNP
cord-289152-w5ynbewh	380	29	-	-	HYPH
cord-289152-w5ynbewh	380	30	beta	beta	NN
cord-289152-w5ynbewh	380	31	-	-	HYPH
cord-289152-w5ynbewh	380	32	activated	activate	VBN
cord-289152-w5ynbewh	380	33	kinase	kinase	NN
cord-289152-w5ynbewh	380	34	1	1	CD
cord-289152-w5ynbewh	380	35	,	,	,
cord-289152-w5ynbewh	380	36	mitogenactivated	mitogenactivated	JJ
cord-289152-w5ynbewh	380	37	kinase	kinase	NN
cord-289152-w5ynbewh	380	38	/	/	SYM
cord-289152-w5ynbewh	380	39	extracellular	extracellular	JJ
cord-289152-w5ynbewh	380	40	signal	signal	NN
cord-289152-w5ynbewh	380	41	-	-	HYPH
cord-289152-w5ynbewh	380	42	regulated	regulate	VBN
cord-289152-w5ynbewh	380	43	kinase	kinase	NN
cord-289152-w5ynbewh	380	44	kinase	kinase	NN
cord-289152-w5ynbewh	380	45	1	1	CD
cord-289152-w5ynbewh	380	46	,	,	,
cord-289152-w5ynbewh	380	47	and	and	CC
cord-289152-w5ynbewh	380	48	I	-PRON-	PRP
cord-289152-w5ynbewh	380	49	kappa	kappa	NN
cord-289152-w5ynbewh	380	50	B	B	NNP
cord-289152-w5ynbewh	380	51	kinase	kinase	VBZ
cord-289152-w5ynbewh	380	52	Immunity	immunity	NN
cord-289152-w5ynbewh	380	53	to	to	IN
cord-289152-w5ynbewh	380	54	PRRSV	PRRSV	NNP
cord-289152-w5ynbewh	380	55	:	:	:
cord-289152-w5ynbewh	380	56	double	double	RB
cord-289152-w5ynbewh	380	57	-	-	HYPH
cord-289152-w5ynbewh	380	58	edged	edge	VBN
cord-289152-w5ynbewh	380	59	sword	sword	NN
cord-289152-w5ynbewh	380	60	Immunological	immunological	JJ
cord-289152-w5ynbewh	380	61	responses	response	NNS
cord-289152-w5ynbewh	380	62	of	of	IN
cord-289152-w5ynbewh	380	63	swine	swine	NN
cord-289152-w5ynbewh	380	64	to	to	IN
cord-289152-w5ynbewh	380	65	porcine	porcine	JJ
cord-289152-w5ynbewh	380	66	reproductive	reproductive	JJ
cord-289152-w5ynbewh	380	67	and	and	CC
cord-289152-w5ynbewh	380	68	respiratory	respiratory	JJ
cord-289152-w5ynbewh	380	69	syndrome	syndrome	NN
cord-289152-w5ynbewh	380	70	virus	virus	NN
cord-289152-w5ynbewh	380	71	infection	infection	NN
cord-289152-w5ynbewh	380	72	Serum	serum	NN
cord-289152-w5ynbewh	380	73	immune	immune	JJ
cord-289152-w5ynbewh	380	74	responses	response	NNS
cord-289152-w5ynbewh	380	75	to	to	IN
cord-289152-w5ynbewh	380	76	the	the	DT
cord-289152-w5ynbewh	380	77	proteins	protein	NNS
cord-289152-w5ynbewh	380	78	of	of	IN
cord-289152-w5ynbewh	380	79	porcine	porcine	JJ
cord-289152-w5ynbewh	380	80	reproductive	reproductive	JJ
cord-289152-w5ynbewh	380	81	and	and	CC
cord-289152-w5ynbewh	380	82	respiratory	respiratory	JJ
cord-289152-w5ynbewh	380	83	syndrome	syndrome	NN
cord-289152-w5ynbewh	381	1	(	(	-LRB-
cord-289152-w5ynbewh	381	2	PRRS	PRRS	NNP
cord-289152-w5ynbewh	381	3	)	)	-RRB-
cord-289152-w5ynbewh	381	4	virus	virus	NN
cord-289152-w5ynbewh	381	5	Active	active	JJ
cord-289152-w5ynbewh	381	6	NF	NF	NNP
cord-289152-w5ynbewh	381	7	-	-	HYPH
cord-289152-w5ynbewh	381	8	kappaB	kappaB	NNP
cord-289152-w5ynbewh	381	9	signalling	signalling	NN
cord-289152-w5ynbewh	381	10	is	be	VBZ
cord-289152-w5ynbewh	381	11	a	a	DT
cord-289152-w5ynbewh	381	12	prerequisite	prerequisite	NN
cord-289152-w5ynbewh	381	13	for	for	IN
cord-289152-w5ynbewh	381	14	influenza	influenza	NN
cord-289152-w5ynbewh	381	15	virus	virus	NN
cord-289152-w5ynbewh	381	16	infection	infection	NN
cord-289152-w5ynbewh	382	1	Human	Human	NNP
cord-289152-w5ynbewh	382	2	T	t	NN
cord-289152-w5ynbewh	382	3	-	-	HYPH
cord-289152-w5ynbewh	382	4	cell	cell	NN
cord-289152-w5ynbewh	382	5	lymphotropic	lymphotropic	NNP
cord-289152-w5ynbewh	382	6	virus	virus	NN
cord-289152-w5ynbewh	382	7	type	type	NN
cord-289152-w5ynbewh	382	8	1	1	CD
cord-289152-w5ynbewh	382	9	tax	tax	NN
cord-289152-w5ynbewh	382	10	induction	induction	NN
cord-289152-w5ynbewh	382	11	of	of	IN
cord-289152-w5ynbewh	382	12	biologically	biologically	RB
cord-289152-w5ynbewh	382	13	active	active	JJ
cord-289152-w5ynbewh	382	14	NF	nf	NN
cord-289152-w5ynbewh	382	15	-	-	HYPH
cord-289152-w5ynbewh	382	16	kappaB	kappaB	NNP
cord-289152-w5ynbewh	382	17	requires	require	VBZ
cord-289152-w5ynbewh	382	18	IkappaB	ikappab	XX
cord-289152-w5ynbewh	382	19	kinase-1-mediated	kinase-1-mediate	VBN
cord-289152-w5ynbewh	382	20	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	382	21	of	of	IN
cord-289152-w5ynbewh	382	22	RelA	RelA	NNP
cord-289152-w5ynbewh	382	23	/	/	SYM
cord-289152-w5ynbewh	382	24	p65	p65	NN
cord-289152-w5ynbewh	382	25	Herpes	Herpes	NNP
cord-289152-w5ynbewh	382	26	simplex	simplex	NN
cord-289152-w5ynbewh	382	27	type	type	NN
cord-289152-w5ynbewh	382	28	1	1	CD
cord-289152-w5ynbewh	382	29	induction	induction	NN
cord-289152-w5ynbewh	382	30	of	of	IN
cord-289152-w5ynbewh	382	31	persistent	persistent	JJ
cord-289152-w5ynbewh	382	32	NF	nf	NN
cord-289152-w5ynbewh	382	33	-	-	HYPH
cord-289152-w5ynbewh	382	34	kappa	kappa	NNP
cord-289152-w5ynbewh	382	35	B	B	NNP
cord-289152-w5ynbewh	382	36	nuclear	nuclear	JJ
cord-289152-w5ynbewh	382	37	translocation	translocation	NN
cord-289152-w5ynbewh	382	38	increases	increase	VBZ
cord-289152-w5ynbewh	382	39	the	the	DT
cord-289152-w5ynbewh	382	40	efficiency	efficiency	NN
cord-289152-w5ynbewh	382	41	of	of	IN
cord-289152-w5ynbewh	382	42	virus	virus	NN
cord-289152-w5ynbewh	382	43	replication	replication	NN
cord-289152-w5ynbewh	382	44	Oxidants	oxidant	NNS
cord-289152-w5ynbewh	382	45	and	and	CC
cord-289152-w5ynbewh	382	46	antioxidants	antioxidant	NNS
cord-289152-w5ynbewh	382	47	in	in	IN
cord-289152-w5ynbewh	382	48	viral	viral	JJ
cord-289152-w5ynbewh	382	49	diseases	disease	NNS
cord-289152-w5ynbewh	382	50	:	:	:
cord-289152-w5ynbewh	382	51	disease	disease	NN
cord-289152-w5ynbewh	382	52	mechanisms	mechanism	NNS
cord-289152-w5ynbewh	382	53	and	and	CC
cord-289152-w5ynbewh	382	54	metabolic	metabolic	JJ
cord-289152-w5ynbewh	382	55	regulation	regulation	NN
cord-289152-w5ynbewh	383	1	A	a	DT
cord-289152-w5ynbewh	383	2	new	new	JJ
cord-289152-w5ynbewh	383	3	mathematical	mathematical	JJ
cord-289152-w5ynbewh	383	4	model	model	NN
cord-289152-w5ynbewh	383	5	for	for	IN
cord-289152-w5ynbewh	383	6	relative	relative	JJ
cord-289152-w5ynbewh	383	7	quantification	quantification	NN
cord-289152-w5ynbewh	383	8	in	in	IN
cord-289152-w5ynbewh	383	9	real	real	JJ
cord-289152-w5ynbewh	383	10	-	-	HYPH
cord-289152-w5ynbewh	383	11	time	time	NN
cord-289152-w5ynbewh	383	12	RT	rt	NN
cord-289152-w5ynbewh	383	13	-	-	HYPH
cord-289152-w5ynbewh	383	14	PCR	PCR	NNP
cord-289152-w5ynbewh	383	15	Lactate	Lactate	NNP
cord-289152-w5ynbewh	383	16	dehydrogenase	dehydrogenase	NN
cord-289152-w5ynbewh	383	17	-	-	HYPH
cord-289152-w5ynbewh	383	18	elevating	elevate	VBG
cord-289152-w5ynbewh	383	19	virus	virus	NN
cord-289152-w5ynbewh	383	20	and	and	CC
cord-289152-w5ynbewh	383	21	related	relate	VBN
cord-289152-w5ynbewh	383	22	viruses	virus	NNS
cord-289152-w5ynbewh	384	1	An	an	DT
cord-289152-w5ynbewh	384	2	IkappaB	IkappaB	NNP
cord-289152-w5ynbewh	384	3	homolog	homolog	NN
cord-289152-w5ynbewh	384	4	encoded	encode	VBN
cord-289152-w5ynbewh	384	5	by	by	IN
cord-289152-w5ynbewh	384	6	African	african	JJ
cord-289152-w5ynbewh	384	7	swine	swine	NN
cord-289152-w5ynbewh	384	8	fever	fever	NN
cord-289152-w5ynbewh	384	9	virus	virus	NN
cord-289152-w5ynbewh	384	10	provides	provide	VBZ
cord-289152-w5ynbewh	384	11	a	a	DT
cord-289152-w5ynbewh	384	12	novel	novel	JJ
cord-289152-w5ynbewh	384	13	mechanism	mechanism	NN
cord-289152-w5ynbewh	384	14	for	for	IN
cord-289152-w5ynbewh	384	15	downregulation	downregulation	NN
cord-289152-w5ynbewh	384	16	of	of	IN
cord-289152-w5ynbewh	384	17	proinflammatory	proinflammatory	JJ
cord-289152-w5ynbewh	384	18	cytokine	cytokine	NN
cord-289152-w5ynbewh	384	19	responses	response	NNS
cord-289152-w5ynbewh	384	20	in	in	IN
cord-289152-w5ynbewh	384	21	host	host	NN
cord-289152-w5ynbewh	384	22	macrophages	macrophage	NNS
cord-289152-w5ynbewh	384	23	Method	method	NN
cord-289152-w5ynbewh	384	24	of	of	IN
cord-289152-w5ynbewh	384	25	determining	determine	VBG
cord-289152-w5ynbewh	384	26	fifty	fifty	CD
cord-289152-w5ynbewh	384	27	percent	percent	NN
cord-289152-w5ynbewh	384	28	endpoints	endpoint	NNS
cord-289152-w5ynbewh	384	29	Pathogenesis	Pathogenesis	NNP
cord-289152-w5ynbewh	384	30	of	of	IN
cord-289152-w5ynbewh	384	31	porcine	porcine	JJ
cord-289152-w5ynbewh	384	32	reproductive	reproductive	JJ
cord-289152-w5ynbewh	384	33	and	and	CC
cord-289152-w5ynbewh	384	34	respiratory	respiratory	JJ
cord-289152-w5ynbewh	384	35	syndrome	syndrome	NN
cord-289152-w5ynbewh	384	36	virus	virus	NN
cord-289152-w5ynbewh	384	37	infection	infection	NN
cord-289152-w5ynbewh	384	38	in	in	IN
cord-289152-w5ynbewh	384	39	gnotobiotic	gnotobiotic	JJ
cord-289152-w5ynbewh	384	40	pigs	pig	NNS
cord-289152-w5ynbewh	384	41	Fetal	fetal	JJ
cord-289152-w5ynbewh	384	42	microscopic	microscopic	JJ
cord-289152-w5ynbewh	384	43	lesions	lesion	NNS
cord-289152-w5ynbewh	384	44	in	in	IN
cord-289152-w5ynbewh	384	45	porcine	porcine	JJ
cord-289152-w5ynbewh	384	46	reproductive	reproductive	JJ
cord-289152-w5ynbewh	384	47	and	and	CC
cord-289152-w5ynbewh	384	48	respiratory	respiratory	JJ
cord-289152-w5ynbewh	384	49	syndrome	syndrome	NN
cord-289152-w5ynbewh	384	50	virus	virus	NN
cord-289152-w5ynbewh	384	51	-	-	HYPH
cord-289152-w5ynbewh	384	52	induced	induce	VBN
cord-289152-w5ynbewh	384	53	abortion	abortion	NN
cord-289152-w5ynbewh	384	54	NF	nf	NN
cord-289152-w5ynbewh	384	55	-	-	HYPH
cord-289152-w5ynbewh	384	56	kappaB	kappaB	NNP
cord-289152-w5ynbewh	384	57	and	and	CC
cord-289152-w5ynbewh	384	58	virus	virus	NN
cord-289152-w5ynbewh	384	59	infection	infection	NN
cord-289152-w5ynbewh	384	60	:	:	:
cord-289152-w5ynbewh	384	61	who	who	WP
cord-289152-w5ynbewh	384	62	controls	control	VBZ
cord-289152-w5ynbewh	384	63	whom	whom	WP
cord-289152-w5ynbewh	384	64	Analytical	analytical	JJ
cord-289152-w5ynbewh	384	65	and	and	CC
cord-289152-w5ynbewh	384	66	numerical	numerical	JJ
cord-289152-w5ynbewh	384	67	techniques	technique	NNS
cord-289152-w5ynbewh	384	68	for	for	IN
cord-289152-w5ynbewh	384	69	the	the	DT
cord-289152-w5ynbewh	384	70	evaluation	evaluation	NN
cord-289152-w5ynbewh	384	71	of	of	IN
cord-289152-w5ynbewh	384	72	free	free	JJ
cord-289152-w5ynbewh	384	73	radical	radical	JJ
cord-289152-w5ynbewh	384	74	damage	damage	NN
cord-289152-w5ynbewh	384	75	in	in	IN
cord-289152-w5ynbewh	384	76	cultured	cultured	JJ
cord-289152-w5ynbewh	384	77	cells	cell	NNS
cord-289152-w5ynbewh	384	78	using	use	VBG
cord-289152-w5ynbewh	384	79	scanning	scan	VBG
cord-289152-w5ynbewh	384	80	laser	laser	NN
cord-289152-w5ynbewh	384	81	microscopy	microscopy	NN
cord-289152-w5ynbewh	384	82	Oxidative	oxidative	JJ
cord-289152-w5ynbewh	384	83	stress	stress	NN
cord-289152-w5ynbewh	384	84	during	during	IN
cord-289152-w5ynbewh	384	85	viral	viral	JJ
cord-289152-w5ynbewh	384	86	infection	infection	NN
cord-289152-w5ynbewh	384	87	:	:	:
cord-289152-w5ynbewh	384	88	a	a	DT
cord-289152-w5ynbewh	384	89	review	review	NN
cord-289152-w5ynbewh	384	90	NF	nf	NN
cord-289152-w5ynbewh	384	91	-	-	HYPH
cord-289152-w5ynbewh	384	92	kappaB	kappaB	NNP
cord-289152-w5ynbewh	384	93	-	-	HYPH
cord-289152-w5ynbewh	384	94	mediated	mediate	VBN
cord-289152-w5ynbewh	384	95	inhibition	inhibition	NN
cord-289152-w5ynbewh	384	96	of	of	IN
cord-289152-w5ynbewh	384	97	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	384	98	is	be	VBZ
cord-289152-w5ynbewh	384	99	required	require	VBN
cord-289152-w5ynbewh	384	100	for	for	IN
cord-289152-w5ynbewh	384	101	encephalomyocarditis	encephalomyocarditis	NNP
cord-289152-w5ynbewh	384	102	virus	virus	NN
cord-289152-w5ynbewh	384	103	virulence	virulence	NN
cord-289152-w5ynbewh	384	104	:	:	:
cord-289152-w5ynbewh	384	105	a	a	DT
cord-289152-w5ynbewh	384	106	mechanism	mechanism	NN
cord-289152-w5ynbewh	384	107	of	of	IN
cord-289152-w5ynbewh	384	108	resistance	resistance	NN
cord-289152-w5ynbewh	384	109	in	in	IN
cord-289152-w5ynbewh	384	110	p50	p50	NN
cord-289152-w5ynbewh	384	111	knockout	knockout	NN
cord-289152-w5ynbewh	384	112	mice	mouse	NNS
cord-289152-w5ynbewh	385	1	The	the	DT
cord-289152-w5ynbewh	385	2	vaccinia	vaccinia	NN
cord-289152-w5ynbewh	385	3	virus	virus	NN
cord-289152-w5ynbewh	385	4	K1L	k1l	CD
cord-289152-w5ynbewh	385	5	gene	gene	NN
cord-289152-w5ynbewh	385	6	product	product	NN
cord-289152-w5ynbewh	385	7	inhibits	inhibit	VBZ
cord-289152-w5ynbewh	385	8	host	host	NN
cord-289152-w5ynbewh	385	9	NF	NF	NNP
cord-289152-w5ynbewh	385	10	-	-	HYPH
cord-289152-w5ynbewh	385	11	kappaB	kappaB	NNP
cord-289152-w5ynbewh	385	12	activation	activation	NN
cord-289152-w5ynbewh	385	13	by	by	IN
cord-289152-w5ynbewh	385	14	preventing	prevent	VBG
cord-289152-w5ynbewh	385	15	IkappaBalpha	IkappaBalpha	NNP
cord-289152-w5ynbewh	385	16	degradation	degradation	NN
cord-289152-w5ynbewh	386	1	A	a	DT
cord-289152-w5ynbewh	386	2	pneumo	pneumo	NN
cord-289152-w5ynbewh	386	3	-	-	HYPH
cord-289152-w5ynbewh	386	4	virulent	virulent	JJ
cord-289152-w5ynbewh	386	5	United	United	NNP
cord-289152-w5ynbewh	386	6	States	States	NNP
cord-289152-w5ynbewh	386	7	isolate	isolate	VBP
cord-289152-w5ynbewh	386	8	of	of	IN
cord-289152-w5ynbewh	386	9	porcine	porcine	JJ
cord-289152-w5ynbewh	386	10	reproductive	reproductive	JJ
cord-289152-w5ynbewh	386	11	and	and	CC
cord-289152-w5ynbewh	386	12	respiratory	respiratory	JJ
cord-289152-w5ynbewh	386	13	syndrome	syndrome	NN
cord-289152-w5ynbewh	386	14	virus	virus	NN
cord-289152-w5ynbewh	386	15	induces	induce	VBZ
cord-289152-w5ynbewh	386	16	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	386	17	in	in	IN
cord-289152-w5ynbewh	386	18	bystander	bystander	NN
cord-289152-w5ynbewh	386	19	cells	cell	NNS
cord-289152-w5ynbewh	386	20	both	both	DT
cord-289152-w5ynbewh	386	21	in	in	IN
cord-289152-w5ynbewh	386	22	vitro	vitro	FW
cord-289152-w5ynbewh	386	23	and	and	CC
cord-289152-w5ynbewh	386	24	in	in	IN
cord-289152-w5ynbewh	386	25	vivo	vivo	NNP
cord-289152-w5ynbewh	386	26	Cytomegalovirus	Cytomegalovirus	NNP
cord-289152-w5ynbewh	386	27	gene	gene	NN
cord-289152-w5ynbewh	386	28	regulation	regulation	NN
cord-289152-w5ynbewh	386	29	by	by	IN
cord-289152-w5ynbewh	386	30	reactive	reactive	JJ
cord-289152-w5ynbewh	386	31	oxygen	oxygen	NN
cord-289152-w5ynbewh	386	32	species	specie	NNS
cord-289152-w5ynbewh	386	33	.	.	.
cord-289152-w5ynbewh	387	1	Agents	agent	NNS
cord-289152-w5ynbewh	387	2	in	in	IN
cord-289152-w5ynbewh	387	3	atherosclerosis	atherosclerosis	NN
cord-289152-w5ynbewh	387	4	Role	role	NN
cord-289152-w5ynbewh	387	5	of	of	IN
cord-289152-w5ynbewh	387	6	NF	NF	NNP
cord-289152-w5ynbewh	387	7	-	-	HYPH
cord-289152-w5ynbewh	387	8	kappaB	kappaB	NNP
cord-289152-w5ynbewh	387	9	and	and	CC
cord-289152-w5ynbewh	387	10	myc	myc	NNP
cord-289152-w5ynbewh	387	11	proteins	protein	NNS
cord-289152-w5ynbewh	387	12	in	in	IN
cord-289152-w5ynbewh	387	13	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	387	14	induced	induce	VBN
cord-289152-w5ynbewh	387	15	by	by	IN
cord-289152-w5ynbewh	387	16	hepatitis	hepatitis	NNP
cord-289152-w5ynbewh	387	17	B	B	NNP
cord-289152-w5ynbewh	387	18	virus	virus	NN
cord-289152-w5ynbewh	387	19	HBx	hbx	NN
cord-289152-w5ynbewh	387	20	protein	protein	NN
cord-289152-w5ynbewh	387	21	Epstein	Epstein	NNP
cord-289152-w5ynbewh	387	22	-Barr	-Barr	NNP
cord-289152-w5ynbewh	387	23	virus	virus	NN
cord-289152-w5ynbewh	387	24	binding	bind	VBG
cord-289152-w5ynbewh	387	25	to	to	IN
cord-289152-w5ynbewh	387	26	CD21	CD21	NNP
cord-289152-w5ynbewh	387	27	activates	activate	VBZ
cord-289152-w5ynbewh	387	28	the	the	DT
cord-289152-w5ynbewh	387	29	initial	initial	JJ
cord-289152-w5ynbewh	387	30	viral	viral	JJ
cord-289152-w5ynbewh	387	31	promoter	promoter	NN
cord-289152-w5ynbewh	387	32	via	via	IN
cord-289152-w5ynbewh	387	33	NF	NF	NNP
cord-289152-w5ynbewh	387	34	-	-	HYPH
cord-289152-w5ynbewh	387	35	kappaB	kappaB	NNP
cord-289152-w5ynbewh	387	36	induction	induction	NN
cord-289152-w5ynbewh	388	1	In	in	IN
cord-289152-w5ynbewh	388	2	vivo	vivo	NN
cord-289152-w5ynbewh	388	3	detection	detection	NN
cord-289152-w5ynbewh	388	4	of	of	IN
cord-289152-w5ynbewh	388	5	porcine	porcine	JJ
cord-289152-w5ynbewh	388	6	reproductive	reproductive	JJ
cord-289152-w5ynbewh	388	7	and	and	CC
cord-289152-w5ynbewh	388	8	respiratory	respiratory	JJ
cord-289152-w5ynbewh	388	9	syndrome	syndrome	NN
cord-289152-w5ynbewh	388	10	virus	virus	NN
cord-289152-w5ynbewh	388	11	RNA	RNA	NNP
cord-289152-w5ynbewh	388	12	by	by	IN
cord-289152-w5ynbewh	388	13	in	in	IN
cord-289152-w5ynbewh	388	14	situ	situ	NN
cord-289152-w5ynbewh	388	15	hybridization	hybridization	NN
cord-289152-w5ynbewh	388	16	at	at	IN
cord-289152-w5ynbewh	388	17	different	different	JJ
cord-289152-w5ynbewh	388	18	times	time	NNS
cord-289152-w5ynbewh	389	1	postinfection	postinfection	NNP
cord-289152-w5ynbewh	389	2	Porcine	porcine	JJ
cord-289152-w5ynbewh	389	3	reproductive	reproductive	JJ
cord-289152-w5ynbewh	389	4	and	and	CC
cord-289152-w5ynbewh	389	5	respiratory	respiratory	JJ
cord-289152-w5ynbewh	389	6	syndrome	syndrome	NN
cord-289152-w5ynbewh	389	7	virus	virus	NN
cord-289152-w5ynbewh	389	8	replicates	replicate	VBZ
cord-289152-w5ynbewh	389	9	in	in	IN
cord-289152-w5ynbewh	389	10	testicular	testicular	JJ
cord-289152-w5ynbewh	389	11	germ	germ	NN
cord-289152-w5ynbewh	389	12	cells	cell	NNS
cord-289152-w5ynbewh	389	13	,	,	,
cord-289152-w5ynbewh	389	14	alters	alter	VBZ
cord-289152-w5ynbewh	389	15	spermatogenesis	spermatogenesis	NN
cord-289152-w5ynbewh	389	16	,	,	,
cord-289152-w5ynbewh	389	17	and	and	CC
cord-289152-w5ynbewh	389	18	induces	induce	VBZ
cord-289152-w5ynbewh	389	19	germ	germ	NN
cord-289152-w5ynbewh	389	20	cell	cell	NN
cord-289152-w5ynbewh	389	21	death	death	NN
cord-289152-w5ynbewh	389	22	by	by	IN
cord-289152-w5ynbewh	389	23	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	390	1	The	the	DT
cord-289152-w5ynbewh	390	2	interferon	interferon	NN
cord-289152-w5ynbewh	390	3	-	-	HYPH
cord-289152-w5ynbewh	390	4	alpha	alpha	NN
cord-289152-w5ynbewh	390	5	/	/	SYM
cord-289152-w5ynbewh	390	6	beta	beta	NN
cord-289152-w5ynbewh	390	7	system	system	NN
cord-289152-w5ynbewh	390	8	in	in	IN
cord-289152-w5ynbewh	390	9	antiviral	antiviral	JJ
cord-289152-w5ynbewh	390	10	responses	response	NNS
cord-289152-w5ynbewh	390	11	:	:	:
cord-289152-w5ynbewh	391	1	a	a	DT
cord-289152-w5ynbewh	391	2	multimodal	multimodal	NN
cord-289152-w5ynbewh	391	3	machinery	machinery	NN
cord-289152-w5ynbewh	391	4	of	of	IN
cord-289152-w5ynbewh	391	5	gene	gene	NN
cord-289152-w5ynbewh	391	6	regulation	regulation	NN
cord-289152-w5ynbewh	391	7	by	by	IN
cord-289152-w5ynbewh	391	8	the	the	DT
cord-289152-w5ynbewh	391	9	IRF	IRF	NNP
cord-289152-w5ynbewh	391	10	family	family	NN
cord-289152-w5ynbewh	391	11	of	of	IN
cord-289152-w5ynbewh	391	12	transcription	transcription	NN
cord-289152-w5ynbewh	391	13	factors	factor	NNS
cord-289152-w5ynbewh	391	14	Respiratory	respiratory	JJ
cord-289152-w5ynbewh	391	15	syncytial	syncytial	JJ
cord-289152-w5ynbewh	391	16	virus	virus	NN
cord-289152-w5ynbewh	391	17	inhibits	inhibit	VBZ
cord-289152-w5ynbewh	391	18	apoptosis	apoptosis	NN
cord-289152-w5ynbewh	391	19	and	and	CC
cord-289152-w5ynbewh	391	20	induces	induce	VBZ
cord-289152-w5ynbewh	391	21	NF	nf	NN
cord-289152-w5ynbewh	391	22	-	-	HYPH
cord-289152-w5ynbewh	391	23	kappa	kappa	NN
cord-289152-w5ynbewh	391	24	B	b	NN
cord-289152-w5ynbewh	391	25	activity	activity	NN
cord-289152-w5ynbewh	391	26	through	through	IN
cord-289152-w5ynbewh	391	27	a	a	DT
cord-289152-w5ynbewh	391	28	phosphatidylinositol	phosphatidylinositol	JJ
cord-289152-w5ynbewh	391	29	3-kinase	3-kinase	CD
cord-289152-w5ynbewh	391	30	-	-	HYPH
cord-289152-w5ynbewh	391	31	dependent	dependent	JJ
cord-289152-w5ynbewh	391	32	pathway	pathway	NN
cord-289152-w5ynbewh	391	33	Proinflammatory	Proinflammatory	NNP
cord-289152-w5ynbewh	391	34	cytokines	cytokine	NNS
cord-289152-w5ynbewh	391	35	and	and	CC
cord-289152-w5ynbewh	391	36	viral	viral	JJ
cord-289152-w5ynbewh	391	37	respiratory	respiratory	JJ
cord-289152-w5ynbewh	391	38	disease	disease	NN
cord-289152-w5ynbewh	391	39	in	in	IN
cord-289152-w5ynbewh	391	40	pigs	pig	NNS
cord-289152-w5ynbewh	391	41	Differential	differential	JJ
cord-289152-w5ynbewh	391	42	production	production	NN
cord-289152-w5ynbewh	391	43	of	of	IN
cord-289152-w5ynbewh	391	44	proinflammatory	proinflammatory	JJ
cord-289152-w5ynbewh	391	45	cytokines	cytokine	NNS
cord-289152-w5ynbewh	391	46	in	in	IN
cord-289152-w5ynbewh	391	47	the	the	DT
cord-289152-w5ynbewh	391	48	pig	pig	NN
cord-289152-w5ynbewh	391	49	lung	lung	NN
cord-289152-w5ynbewh	391	50	during	during	IN
cord-289152-w5ynbewh	391	51	different	different	JJ
cord-289152-w5ynbewh	391	52	respiratory	respiratory	JJ
cord-289152-w5ynbewh	391	53	virus	virus	NN
cord-289152-w5ynbewh	391	54	infections	infection	NNS
cord-289152-w5ynbewh	391	55	:	:	:
cord-289152-w5ynbewh	391	56	correlations	correlation	NNS
cord-289152-w5ynbewh	391	57	with	with	IN
cord-289152-w5ynbewh	391	58	pathogenicity	pathogenicity	NN
cord-289152-w5ynbewh	391	59	In	in	IN
cord-289152-w5ynbewh	391	60	vivo	vivo	NN
cord-289152-w5ynbewh	391	61	studies	study	NNS
cord-289152-w5ynbewh	391	62	on	on	IN
cord-289152-w5ynbewh	391	63	cytokine	cytokine	JJ
cord-289152-w5ynbewh	391	64	involvement	involvement	NN
cord-289152-w5ynbewh	391	65	during	during	IN
cord-289152-w5ynbewh	391	66	acute	acute	JJ
cord-289152-w5ynbewh	391	67	viral	viral	JJ
cord-289152-w5ynbewh	391	68	respiratory	respiratory	JJ
cord-289152-w5ynbewh	391	69	disease	disease	NN
cord-289152-w5ynbewh	391	70	of	of	IN
cord-289152-w5ynbewh	391	71	swine	swine	NN
cord-289152-w5ynbewh	391	72	:	:	:
cord-289152-w5ynbewh	391	73	troublesome	troublesome	JJ
cord-289152-w5ynbewh	391	74	but	but	CC
cord-289152-w5ynbewh	391	75	rewarding	rewarding	JJ
cord-289152-w5ynbewh	392	1	Influenza	Influenza	NNP
cord-289152-w5ynbewh	392	2	A	a	DT
cord-289152-w5ynbewh	392	3	virus	virus	NN
cord-289152-w5ynbewh	392	4	NS1	ns1	NN
cord-289152-w5ynbewh	392	5	protein	protein	NN
cord-289152-w5ynbewh	392	6	prevents	prevent	VBZ
cord-289152-w5ynbewh	392	7	activation	activation	NN
cord-289152-w5ynbewh	392	8	of	of	IN
cord-289152-w5ynbewh	392	9	NF	NF	NNP
cord-289152-w5ynbewh	392	10	-	-	HYPH
cord-289152-w5ynbewh	392	11	kappaB	kappaB	NNP
cord-289152-w5ynbewh	392	12	and	and	CC
cord-289152-w5ynbewh	392	13	induction	induction	NN
cord-289152-w5ynbewh	392	14	of	of	IN
cord-289152-w5ynbewh	392	15	alpha	alpha	NN
cord-289152-w5ynbewh	392	16	/	/	SYM
cord-289152-w5ynbewh	392	17	beta	beta	NN
cord-289152-w5ynbewh	393	1	interferon	interferon	NNP
cord-289152-w5ynbewh	394	1	Mitochondrially	Mitochondrially	NNP
cord-289152-w5ynbewh	394	2	associated	associate	VBN
cord-289152-w5ynbewh	395	1	hepatitis	hepatitis	NNP
cord-289152-w5ynbewh	395	2	B	B	NNP
cord-289152-w5ynbewh	395	3	virus	virus	NN
cord-289152-w5ynbewh	395	4	X	x	NN
cord-289152-w5ynbewh	395	5	protein	protein	NN
cord-289152-w5ynbewh	395	6	constitutively	constitutively	RB
cord-289152-w5ynbewh	395	7	activates	activate	VBZ
cord-289152-w5ynbewh	395	8	transcription	transcription	NN
cord-289152-w5ynbewh	395	9	factors	factor	NNS
cord-289152-w5ynbewh	395	10	STAT-3	STAT-3	NNP
cord-289152-w5ynbewh	395	11	and	and	CC
cord-289152-w5ynbewh	395	12	NF	nf	NN
cord-289152-w5ynbewh	395	13	-	-	HYPH
cord-289152-w5ynbewh	395	14	kappa	kappa	NN
cord-289152-w5ynbewh	395	15	B	b	NN
cord-289152-w5ynbewh	395	16	via	via	IN
cord-289152-w5ynbewh	395	17	oxidative	oxidative	JJ
cord-289152-w5ynbewh	395	18	stress	stress	NN
cord-289152-w5ynbewh	395	19	Hepatitis	Hepatitis	NNP
cord-289152-w5ynbewh	395	20	C	C	NNP
cord-289152-w5ynbewh	395	21	virus	virus	NN
cord-289152-w5ynbewh	396	1	NS5A	NS5A	NNP
cord-289152-w5ynbewh	396	2	and	and	CC
cord-289152-w5ynbewh	397	1	subgenomic	subgenomic	NNP
cord-289152-w5ynbewh	397	2	replicon	replicon	NNP
cord-289152-w5ynbewh	397	3	activate	activate	VBP
cord-289152-w5ynbewh	397	4	NF	NF	NNP
cord-289152-w5ynbewh	397	5	-	-	HYPH
cord-289152-w5ynbewh	397	6	kappaB	kappaB	NNP
cord-289152-w5ynbewh	397	7	via	via	IN
cord-289152-w5ynbewh	397	8	tyrosine	tyrosine	NN
cord-289152-w5ynbewh	397	9	phosphorylation	phosphorylation	NN
cord-289152-w5ynbewh	397	10	of	of	IN
cord-289152-w5ynbewh	397	11	IkappaBalpha	IkappaBalpha	NNP
cord-289152-w5ynbewh	397	12	and	and	CC
cord-289152-w5ynbewh	397	13	its	-PRON-	PRP$
cord-289152-w5ynbewh	397	14	degradation	degradation	NN
cord-289152-w5ynbewh	397	15	by	by	IN
cord-289152-w5ynbewh	397	16	calpain	calpain	NN
cord-289152-w5ynbewh	397	17	protease	protease	NN
cord-289152-w5ynbewh	397	18	Virus	Virus	NNP
cord-289152-w5ynbewh	397	19	infection	infection	NN
cord-289152-w5ynbewh	397	20	induces	induce	VBZ
cord-289152-w5ynbewh	397	21	the	the	DT
cord-289152-w5ynbewh	397	22	assembly	assembly	NN
cord-289152-w5ynbewh	397	23	of	of	IN
cord-289152-w5ynbewh	397	24	coordinately	coordinately	NNP
cord-289152-w5ynbewh	397	25	activated	activate	VBD
cord-289152-w5ynbewh	397	26	transcription	transcription	NN
cord-289152-w5ynbewh	397	27	factors	factor	NNS
cord-289152-w5ynbewh	397	28	on	on	IN
cord-289152-w5ynbewh	397	29	the	the	DT
cord-289152-w5ynbewh	397	30	IFN	IFN	NNP
cord-289152-w5ynbewh	397	31	-	-	HYPH
cord-289152-w5ynbewh	397	32	beta	beta	NN
cord-289152-w5ynbewh	397	33	enhancer	enhancer	NN
cord-289152-w5ynbewh	397	34	in	in	IN
cord-289152-w5ynbewh	397	35	vivo	vivo	FW
cord-289152-w5ynbewh	397	36	Porcine	porcine	JJ
cord-289152-w5ynbewh	397	37	reproductive	reproductive	JJ
cord-289152-w5ynbewh	397	38	and	and	CC
cord-289152-w5ynbewh	397	39	respiratory	respiratory	JJ
cord-289152-w5ynbewh	397	40	syndrome	syndrome	NN
cord-289152-w5ynbewh	397	41	virus	virus	NN
cord-289152-w5ynbewh	397	42	:	:	:
cord-289152-w5ynbewh	398	1	a	a	DT
cord-289152-w5ynbewh	398	2	persistent	persistent	JJ
cord-289152-w5ynbewh	398	3	infection	infection	NN
cord-289152-w5ynbewh	398	4	Duration	duration	NN
cord-289152-w5ynbewh	398	5	of	of	IN
cord-289152-w5ynbewh	398	6	infection	infection	NN
cord-289152-w5ynbewh	398	7	and	and	CC
cord-289152-w5ynbewh	398	8	proportion	proportion	NN
cord-289152-w5ynbewh	398	9	of	of	IN
cord-289152-w5ynbewh	398	10	pigs	pig	NNS
cord-289152-w5ynbewh	398	11	persistently	persistently	RB
cord-289152-w5ynbewh	398	12	infected	infect	VBN
cord-289152-w5ynbewh	398	13	with	with	IN
cord-289152-w5ynbewh	398	14	porcine	porcine	JJ
cord-289152-w5ynbewh	398	15	reproductive	reproductive	JJ
cord-289152-w5ynbewh	398	16	and	and	CC
cord-289152-w5ynbewh	398	17	respiratory	respiratory	JJ
cord-289152-w5ynbewh	398	18	syndrome	syndrome	NN
cord-289152-w5ynbewh	398	19	virus	virus	NN
cord-289152-w5ynbewh	399	1	The	the	DT
cord-289152-w5ynbewh	399	2	level	level	NN
cord-289152-w5ynbewh	399	3	of	of	IN
cord-289152-w5ynbewh	399	4	virus	virus	NN
cord-289152-w5ynbewh	399	5	-	-	HYPH
cord-289152-w5ynbewh	399	6	specific	specific	JJ
cord-289152-w5ynbewh	399	7	T	t	NN
cord-289152-w5ynbewh	399	8	-	-	HYPH
cord-289152-w5ynbewh	399	9	cell	cell	NN
cord-289152-w5ynbewh	399	10	and	and	CC
cord-289152-w5ynbewh	399	11	macrophage	macrophage	NN
cord-289152-w5ynbewh	399	12	recruitment	recruitment	NN
cord-289152-w5ynbewh	399	13	in	in	IN
cord-289152-w5ynbewh	399	14	porcine	porcine	JJ
cord-289152-w5ynbewh	399	15	reproductive	reproductive	JJ
cord-289152-w5ynbewh	399	16	and	and	CC
cord-289152-w5ynbewh	399	17	respiratory	respiratory	JJ
cord-289152-w5ynbewh	399	18	syndrome	syndrome	NN
cord-289152-w5ynbewh	399	19	virus	virus	NN
cord-289152-w5ynbewh	399	20	infection	infection	NN
cord-289152-w5ynbewh	399	21	in	in	IN
cord-289152-w5ynbewh	399	22	pigs	pig	NNS
cord-289152-w5ynbewh	399	23	is	be	VBZ
cord-289152-w5ynbewh	399	24	independent	independent	JJ
cord-289152-w5ynbewh	399	25	of	of	IN
cord-289152-w5ynbewh	399	26	virus	virus	NN
cord-289152-w5ynbewh	399	27	load	load	NN
cord-289152-w5ynbewh	399	28	Characterization	characterization	NN
cord-289152-w5ynbewh	399	29	of	of	IN
cord-289152-w5ynbewh	399	30	the	the	DT
cord-289152-w5ynbewh	399	31	humoral	humoral	JJ
cord-289152-w5ynbewh	399	32	immune	immune	JJ
cord-289152-w5ynbewh	399	33	response	response	NN
cord-289152-w5ynbewh	399	34	to	to	IN
cord-289152-w5ynbewh	399	35	porcine	porcine	JJ
cord-289152-w5ynbewh	399	36	reproductive	reproductive	JJ
cord-289152-w5ynbewh	399	37	and	and	CC
cord-289152-w5ynbewh	399	38	respiratory	respiratory	JJ
cord-289152-w5ynbewh	399	39	syndrome	syndrome	NN
cord-289152-w5ynbewh	399	40	(	(	-LRB-
cord-289152-w5ynbewh	399	41	PRRS	PRRS	NNP
cord-289152-w5ynbewh	399	42	)	)	-RRB-
cord-289152-w5ynbewh	399	43	virus	virus	NN
cord-289152-w5ynbewh	399	44	infection	infection	NN
cord-289152-w5ynbewh	399	45	Laboratory	Laboratory	NNP
cord-289152-w5ynbewh	399	46	investigation	investigation	NN
cord-289152-w5ynbewh	399	47	of	of	IN
cord-289152-w5ynbewh	399	48	PRRS	PRRS	NNP
cord-289152-w5ynbewh	399	49	virus	virus	NN
cord-289152-w5ynbewh	399	50	infection	infection	NN
cord-289152-w5ynbewh	399	51	in	in	IN
cord-289152-w5ynbewh	399	52	three	three	CD
cord-289152-w5ynbewh	399	53	swine	swine	NN
cord-289152-w5ynbewh	399	54	herds	herd	NNS
cord-289152-w5ynbewh	400	1	The	the	DT
cord-289152-w5ynbewh	400	2	mengovirus	mengovirus	JJ
cord-289152-w5ynbewh	400	3	leader	leader	NN
cord-289152-w5ynbewh	400	4	protein	protein	NN
cord-289152-w5ynbewh	400	5	suppresses	suppress	VBZ
cord-289152-w5ynbewh	400	6	alpha	alpha	NN
cord-289152-w5ynbewh	400	7	/	/	SYM
cord-289152-w5ynbewh	400	8	beta	beta	NN
cord-289152-w5ynbewh	400	9	interferon	interferon	NN
cord-289152-w5ynbewh	400	10	production	production	NN
cord-289152-w5ynbewh	400	11	by	by	IN
cord-289152-w5ynbewh	400	12	inhibition	inhibition	NN
cord-289152-w5ynbewh	400	13	of	of	IN
cord-289152-w5ynbewh	400	14	the	the	DT
cord-289152-w5ynbewh	400	15	iron	iron	NN
cord-289152-w5ynbewh	400	16	/	/	SYM
cord-289152-w5ynbewh	400	17	ferritin	ferritin	NN
cord-289152-w5ynbewh	400	18	-	-	HYPH
cord-289152-w5ynbewh	400	19	mediated	mediate	VBN
cord-289152-w5ynbewh	400	20	activation	activation	NN
cord-289152-w5ynbewh	400	21	of	of	IN
cord-289152-w5ynbewh	400	22	NF	nf	NN
cord-289152-w5ynbewh	400	23	-	-	HYPH
cord-289152-w5ynbewh	400	24	kappa	kappa	NN
cord-289152-w5ynbewh	400	25	B	b	NN