id sid tid token lemma pos cord-296075-8axbkyyz 1 1 key key JJ cord-296075-8axbkyyz 1 2 : : : cord-296075-8axbkyyz 1 3 cord-296075 cord-296075 CD cord-296075-8axbkyyz 1 4 - - HYPH cord-296075-8axbkyyz 1 5 8axbkyyz 8axbkyyz CD cord-296075-8axbkyyz 1 6 authors author NNS cord-296075-8axbkyyz 1 7 : : : cord-296075-8axbkyyz 1 8 Castro Castro NNP cord-296075-8axbkyyz 1 9 , , , cord-296075-8axbkyyz 1 10 Raymond Raymond NNP cord-296075-8axbkyyz 1 11 F. F. NNP cord-296075-8axbkyyz 1 12 ; ; : cord-296075-8axbkyyz 1 13 Perlman Perlman NNP cord-296075-8axbkyyz 1 14 , , , cord-296075-8axbkyyz 1 15 Stanley Stanley NNP cord-296075-8axbkyyz 1 16 title title NN cord-296075-8axbkyyz 1 17 : : : cord-296075-8axbkyyz 1 18 Differential Differential NNP cord-296075-8axbkyyz 1 19 Antigen Antigen NNP cord-296075-8axbkyyz 1 20 Recognition Recognition NNP cord-296075-8axbkyyz 1 21 by by IN cord-296075-8axbkyyz 1 22 T T NNP cord-296075-8axbkyyz 1 23 Cells cell NNS cord-296075-8axbkyyz 1 24 from from IN cord-296075-8axbkyyz 1 25 the the DT cord-296075-8axbkyyz 1 26 Spleen Spleen NNP cord-296075-8axbkyyz 1 27 and and CC cord-296075-8axbkyyz 1 28 Central Central NNP cord-296075-8axbkyyz 1 29 Nervous Nervous NNP cord-296075-8axbkyyz 1 30 System System NNP cord-296075-8axbkyyz 1 31 of of IN cord-296075-8axbkyyz 1 32 Coronavirus Coronavirus NNP cord-296075-8axbkyyz 1 33 - - HYPH cord-296075-8axbkyyz 1 34 Infected infect VBN cord-296075-8axbkyyz 1 35 Mice Mice NNP cord-296075-8axbkyyz 1 36 date date NN cord-296075-8axbkyyz 1 37 : : : cord-296075-8axbkyyz 1 38 1996 1996 CD cord-296075-8axbkyyz 1 39 - - SYM cord-296075-8axbkyyz 1 40 08 08 CD cord-296075-8axbkyyz 1 41 - - HYPH cord-296075-8axbkyyz 1 42 01 01 CD cord-296075-8axbkyyz 1 43 journal journal NN cord-296075-8axbkyyz 1 44 : : : cord-296075-8axbkyyz 2 1 Virology virology NN cord-296075-8axbkyyz 2 2 DOI DOI NNP cord-296075-8axbkyyz 2 3 : : : cord-296075-8axbkyyz 3 1 10.1006/ 10.1006/ LS cord-296075-8axbkyyz 4 1 viro.1996.0415 viro.1996.0415 ADD cord-296075-8axbkyyz 5 1 sha sha NNP cord-296075-8axbkyyz 5 2 : : : cord-296075-8axbkyyz 5 3 2e699e438bfb69f8000218de4a10ca6f29ed68be 2e699e438bfb69f8000218de4a10ca6f29ed68be CD cord-296075-8axbkyyz 6 1 doc_id doc_id CD cord-296075-8axbkyyz 6 2 : : : cord-296075-8axbkyyz 6 3 296075 296075 CD cord-296075-8axbkyyz 6 4 cord_uid cord_uid NNS cord-296075-8axbkyyz 6 5 : : : cord-296075-8axbkyyz 7 1 8axbkyyz 8axbkyyz LS cord-296075-8axbkyyz 7 2 Abstract Abstract NNP cord-296075-8axbkyyz 7 3 CD8+cytotoxic cd8+cytotoxic NN cord-296075-8axbkyyz 7 4 T t NN cord-296075-8axbkyyz 7 5 lymphocytes lymphocyte NNS cord-296075-8axbkyyz 7 6 ( ( -LRB- cord-296075-8axbkyyz 7 7 CTLs CTLs NNP cord-296075-8axbkyyz 7 8 ) ) -RRB- cord-296075-8axbkyyz 7 9 isolated isolate VBN cord-296075-8axbkyyz 7 10 from from IN cord-296075-8axbkyyz 7 11 the the DT cord-296075-8axbkyyz 7 12 central central JJ cord-296075-8axbkyyz 7 13 nervous nervous JJ cord-296075-8axbkyyz 7 14 system system NN cord-296075-8axbkyyz 7 15 ( ( -LRB- cord-296075-8axbkyyz 7 16 CNS CNS NNP cord-296075-8axbkyyz 7 17 ) ) -RRB- cord-296075-8axbkyyz 7 18 of of IN cord-296075-8axbkyyz 7 19 C57Bl/6 C57Bl/6 NNP cord-296075-8axbkyyz 7 20 mice mouse NNS cord-296075-8axbkyyz 7 21 acutely acutely RB cord-296075-8axbkyyz 7 22 infected infect VBN cord-296075-8axbkyyz 7 23 with with IN cord-296075-8axbkyyz 7 24 mouse mouse NN cord-296075-8axbkyyz 7 25 hepatitis hepatitis NNP cord-296075-8axbkyyz 7 26 virus virus NN cord-296075-8axbkyyz 7 27 , , , cord-296075-8axbkyyz 7 28 strain strain VB cord-296075-8axbkyyz 7 29 JHM JHM NNP cord-296075-8axbkyyz 7 30 ( ( -LRB- cord-296075-8axbkyyz 7 31 MHV MHV NNP cord-296075-8axbkyyz 7 32 - - HYPH cord-296075-8axbkyyz 7 33 JHM JHM NNP cord-296075-8axbkyyz 7 34 ) ) -RRB- cord-296075-8axbkyyz 7 35 , , , cord-296075-8axbkyyz 7 36 and and CC cord-296075-8axbkyyz 7 37 analyzed analyze VBD cord-296075-8axbkyyz 7 38 in in IN cord-296075-8axbkyyz 7 39 a a DT cord-296075-8axbkyyz 7 40 directex directex NN cord-296075-8axbkyyz 7 41 vivocytotoxicity vivocytotoxicity NN cord-296075-8axbkyyz 7 42 assay assay NN cord-296075-8axbkyyz 7 43 recognize recognize VB cord-296075-8axbkyyz 7 44 two two CD cord-296075-8axbkyyz 7 45 epitopes epitope NNS cord-296075-8axbkyyz 7 46 ( ( -LRB- cord-296075-8axbkyyz 7 47 H-2Db- H-2Db- NNS cord-296075-8axbkyyz 7 48 and and CC cord-296075-8axbkyyz 7 49 H-2Kb h-2kb RB cord-296075-8axbkyyz 7 50 - - HYPH cord-296075-8axbkyyz 7 51 restricted restrict VBN cord-296075-8axbkyyz 7 52 encompassing encompassing JJ cord-296075-8axbkyyz 7 53 amino amino NN cord-296075-8axbkyyz 7 54 acids acid NNS cord-296075-8axbkyyz 7 55 510–518 510–518 CD cord-296075-8axbkyyz 7 56 and and CC cord-296075-8axbkyyz 7 57 598–605 598–605 CD cord-296075-8axbkyyz 7 58 , , , cord-296075-8axbkyyz 7 59 respectively respectively RB cord-296075-8axbkyyz 7 60 ) ) -RRB- cord-296075-8axbkyyz 7 61 within within IN cord-296075-8axbkyyz 7 62 the the DT cord-296075-8axbkyyz 7 63 surface surface NN cord-296075-8axbkyyz 7 64 ( ( -LRB- cord-296075-8axbkyyz 7 65 S s NN cord-296075-8axbkyyz 7 66 ) ) -RRB- cord-296075-8axbkyyz 7 67 glycoprotein glycoprotein NN cord-296075-8axbkyyz 7 68 . . . cord-296075-8axbkyyz 8 1 In in IN cord-296075-8axbkyyz 8 2 contrast contrast NN cord-296075-8axbkyyz 8 3 , , , cord-296075-8axbkyyz 8 4 CD8+T cd8+t JJ cord-296075-8axbkyyz 8 5 cells cell NNS cord-296075-8axbkyyz 8 6 isolated isolate VBN cord-296075-8axbkyyz 8 7 from from IN cord-296075-8axbkyyz 8 8 the the DT cord-296075-8axbkyyz 8 9 spleens spleen NNS cord-296075-8axbkyyz 8 10 of of IN cord-296075-8axbkyyz 8 11 mice mouse NNS cord-296075-8axbkyyz 8 12 inoculated inoculate VBD cord-296075-8axbkyyz 8 13 intraperitoneally intraperitoneally RB cord-296075-8axbkyyz 8 14 with with IN cord-296075-8axbkyyz 8 15 MHV MHV NNP cord-296075-8axbkyyz 8 16 - - HYPH cord-296075-8axbkyyz 8 17 JHM JHM NNP cord-296075-8axbkyyz 8 18 and and CC cord-296075-8axbkyyz 8 19 restimulatedin restimulatedin NNP cord-296075-8axbkyyz 8 20 vitroonly vitroonly RB cord-296075-8axbkyyz 8 21 respond respond VBP cord-296075-8axbkyyz 8 22 to to IN cord-296075-8axbkyyz 8 23 the the DT cord-296075-8axbkyyz 8 24 H-2Db h-2db NN cord-296075-8axbkyyz 8 25 - - HYPH cord-296075-8axbkyyz 8 26 restricted restrict VBN cord-296075-8axbkyyz 8 27 epitope epitope NN cord-296075-8axbkyyz 8 28 . . . cord-296075-8axbkyyz 9 1 In in IN cord-296075-8axbkyyz 9 2 this this DT cord-296075-8axbkyyz 9 3 report report NN cord-296075-8axbkyyz 9 4 , , , cord-296075-8axbkyyz 9 5 the the DT cord-296075-8axbkyyz 9 6 preferential preferential JJ cord-296075-8axbkyyz 9 7 recognition recognition NN cord-296075-8axbkyyz 9 8 of of IN cord-296075-8axbkyyz 9 9 the the DT cord-296075-8axbkyyz 9 10 H-2Db h-2db RB cord-296075-8axbkyyz 9 11 - - HYPH cord-296075-8axbkyyz 9 12 restricted restrict VBN cord-296075-8axbkyyz 9 13 epitope epitope NN cord-296075-8axbkyyz 9 14 is be VBZ cord-296075-8axbkyyz 9 15 confirmed confirm VBN cord-296075-8axbkyyz 9 16 using use VBG cord-296075-8axbkyyz 9 17 splenocytes splenocytes NNP cord-296075-8axbkyyz 9 18 stimulatedin stimulatedin NNP cord-296075-8axbkyyz 9 19 vitrowith vitrowith NNP cord-296075-8axbkyyz 10 1 either either CC cord-296075-8axbkyyz 10 2 MHV MHV NNP cord-296075-8axbkyyz 10 3 - - HYPH cord-296075-8axbkyyz 10 4 JHM JHM NNP cord-296075-8axbkyyz 10 5 - - HYPH cord-296075-8axbkyyz 10 6 infected infect VBN cord-296075-8axbkyyz 10 7 MC57 MC57 NNP cord-296075-8axbkyyz 10 8 cells cell NNS cord-296075-8axbkyyz 10 9 or or CC cord-296075-8axbkyyz 10 10 with with IN cord-296075-8axbkyyz 10 11 a a DT cord-296075-8axbkyyz 10 12 cell cell NN cord-296075-8axbkyyz 10 13 line line NN cord-296075-8axbkyyz 10 14 expressing express VBG cord-296075-8axbkyyz 10 15 the the DT cord-296075-8axbkyyz 10 16 S S NNP cord-296075-8axbkyyz 10 17 protein protein NN cord-296075-8axbkyyz 10 18 and and CC cord-296075-8axbkyyz 10 19 analyzed analyze VBD cord-296075-8axbkyyz 10 20 in in IN cord-296075-8axbkyyz 10 21 secondary secondary JJ cord-296075-8axbkyyz 10 22 CTL CTL NNP cord-296075-8axbkyyz 10 23 assays assay NNS cord-296075-8axbkyyz 10 24 . . . cord-296075-8axbkyyz 11 1 To to TO cord-296075-8axbkyyz 11 2 determine determine VB cord-296075-8axbkyyz 11 3 whether whether IN cord-296075-8axbkyyz 11 4 these these DT cord-296075-8axbkyyz 11 5 results result NNS cord-296075-8axbkyyz 11 6 represent represent VBP cord-296075-8axbkyyz 11 7 a a DT cord-296075-8axbkyyz 11 8 difference difference NN cord-296075-8axbkyyz 11 9 in in IN cord-296075-8axbkyyz 11 10 epitope epitope NN cord-296075-8axbkyyz 11 11 recognition recognition NN cord-296075-8axbkyyz 11 12 between between IN cord-296075-8axbkyyz 11 13 the the DT cord-296075-8axbkyyz 11 14 spleen spleen NNS cord-296075-8axbkyyz 11 15 and and CC cord-296075-8axbkyyz 11 16 CNS CNS NNP cord-296075-8axbkyyz 11 17 , , , cord-296075-8axbkyyz 11 18 secondary secondary JJ cord-296075-8axbkyyz 11 19 CTL CTL NNP cord-296075-8axbkyyz 11 20 assays assay NNS cord-296075-8axbkyyz 11 21 were be VBD cord-296075-8axbkyyz 11 22 performed perform VBN cord-296075-8axbkyyz 11 23 using use VBG cord-296075-8axbkyyz 11 24 spleen spleen NN cord-296075-8axbkyyz 11 25 cells cell NNS cord-296075-8axbkyyz 11 26 coated coat VBN cord-296075-8axbkyyz 11 27 with with IN cord-296075-8axbkyyz 11 28 peptides peptide NNS cord-296075-8axbkyyz 11 29 encompassing encompass VBG cord-296075-8axbkyyz 11 30 the the DT cord-296075-8axbkyyz 11 31 CTL CTL NNP cord-296075-8axbkyyz 11 32 epitopes epitope NNS cord-296075-8axbkyyz 11 33 as as IN cord-296075-8axbkyyz 11 34 stimulators stimulator NNS cord-296075-8axbkyyz 11 35 . . . cord-296075-8axbkyyz 12 1 Under under IN cord-296075-8axbkyyz 12 2 these these DT cord-296075-8axbkyyz 12 3 conditions condition NNS cord-296075-8axbkyyz 12 4 , , , cord-296075-8axbkyyz 12 5 both both DT cord-296075-8axbkyyz 12 6 epitopes epitope NNS cord-296075-8axbkyyz 12 7 sensitized sensitize VBN cord-296075-8axbkyyz 12 8 cells cell NNS cord-296075-8axbkyyz 12 9 for for IN cord-296075-8axbkyyz 12 10 lysis lysis NN cord-296075-8axbkyyz 12 11 by by IN cord-296075-8axbkyyz 12 12 spleen spleen NN cord-296075-8axbkyyz 12 13 - - HYPH cord-296075-8axbkyyz 12 14 derived derive VBN cord-296075-8axbkyyz 12 15 CTLs ctl NNS cord-296075-8axbkyyz 12 16 , , , cord-296075-8axbkyyz 12 17 suggesting suggest VBG cord-296075-8axbkyyz 12 18 that that IN cord-296075-8axbkyyz 12 19 both both DT cord-296075-8axbkyyz 12 20 epitopes epitope NNS cord-296075-8axbkyyz 12 21 were be VBD cord-296075-8axbkyyz 12 22 recognized recognize VBN cord-296075-8axbkyyz 12 23 by by IN cord-296075-8axbkyyz 12 24 splenic splenic JJ cord-296075-8axbkyyz 12 25 CD8+T cd8+t IN cord-296075-8axbkyyz 12 26 cells cell NNS cord-296075-8axbkyyz 12 27 after after IN cord-296075-8axbkyyz 12 28 infectionin infectionin NNP cord-296075-8axbkyyz 12 29 vivo vivo NNP cord-296075-8axbkyyz 12 30 . . . cord-296075-8axbkyyz 13 1 Furthermore furthermore RB cord-296075-8axbkyyz 13 2 , , , cord-296075-8axbkyyz 13 3 limiting limit VBG cord-296075-8axbkyyz 13 4 dilution dilution NN cord-296075-8axbkyyz 13 5 analysis analysis NN cord-296075-8axbkyyz 13 6 indicated indicate VBD cord-296075-8axbkyyz 13 7 that that IN cord-296075-8axbkyyz 13 8 the the DT cord-296075-8axbkyyz 13 9 precursor precursor NN cord-296075-8axbkyyz 13 10 frequency frequency NN cord-296075-8axbkyyz 13 11 of of IN cord-296075-8axbkyyz 13 12 splenic splenic JJ cord-296075-8axbkyyz 13 13 CD8+T cd8+t IN cord-296075-8axbkyyz 13 14 cells cell NNS cord-296075-8axbkyyz 13 15 specific specific JJ cord-296075-8axbkyyz 13 16 for for IN cord-296075-8axbkyyz 13 17 both both CC cord-296075-8axbkyyz 13 18 the the DT cord-296075-8axbkyyz 13 19 H-2Kb- H-2Kb- NNS cord-296075-8axbkyyz 13 20 and and CC cord-296075-8axbkyyz 13 21 H-2Db H-2Db NNS cord-296075-8axbkyyz 13 22 - - HYPH cord-296075-8axbkyyz 13 23 restricted restrict VBN cord-296075-8axbkyyz 13 24 epitopes epitope NNS cord-296075-8axbkyyz 13 25 were be VBD cord-296075-8axbkyyz 13 26 not not RB cord-296075-8axbkyyz 13 27 significantly significantly RB cord-296075-8axbkyyz 13 28 different different JJ cord-296075-8axbkyyz 13 29 . . . cord-296075-8axbkyyz 14 1 Thus thus RB cord-296075-8axbkyyz 14 2 , , , cord-296075-8axbkyyz 14 3 the the DT cord-296075-8axbkyyz 14 4 results result NNS cord-296075-8axbkyyz 14 5 suggest suggest VBP cord-296075-8axbkyyz 14 6 thatin thatin NNP cord-296075-8axbkyyz 14 7 vitrostimulation vitrostimulation NN cord-296075-8axbkyyz 14 8 of of IN cord-296075-8axbkyyz 14 9 splenocytes splenocytes NNP cord-296075-8axbkyyz 14 10 specific specific JJ cord-296075-8axbkyyz 14 11 for for IN cord-296075-8axbkyyz 14 12 the the DT cord-296075-8axbkyyz 14 13 H-2Kb h-2kb RB cord-296075-8axbkyyz 14 14 - - HYPH cord-296075-8axbkyyz 14 15 restricted restrict VBN cord-296075-8axbkyyz 14 16 epitope epitope NN cord-296075-8axbkyyz 14 17 is be VBZ cord-296075-8axbkyyz 14 18 inefficient inefficient JJ cord-296075-8axbkyyz 14 19 after after IN cord-296075-8axbkyyz 14 20 endogenous endogenous JJ cord-296075-8axbkyyz 14 21 processing processing NN cord-296075-8axbkyyz 14 22 but but CC cord-296075-8axbkyyz 14 23 that that IN cord-296075-8axbkyyz 14 24 this this DT cord-296075-8axbkyyz 14 25 inefficiency inefficiency NN cord-296075-8axbkyyz 14 26 can can MD cord-296075-8axbkyyz 14 27 be be VB cord-296075-8axbkyyz 14 28 corrected correct VBN cord-296075-8axbkyyz 14 29 if if IN cord-296075-8axbkyyz 14 30 peptide peptide NN cord-296075-8axbkyyz 14 31 is be VBZ cord-296075-8axbkyyz 14 32 provided provide VBN cord-296075-8axbkyyz 14 33 exogenously exogenously RB cord-296075-8axbkyyz 14 34 at at IN cord-296075-8axbkyyz 14 35 sufficiently sufficiently RB cord-296075-8axbkyyz 14 36 high high JJ cord-296075-8axbkyyz 14 37 concentrations concentration NNS cord-296075-8axbkyyz 14 38 . . . cord-296075-8axbkyyz 15 1 As as IN cord-296075-8axbkyyz 15 2 a a DT cord-296075-8axbkyyz 15 3 consequence consequence NN cord-296075-8axbkyyz 15 4 , , , cord-296075-8axbkyyz 15 5 the the DT cord-296075-8axbkyyz 15 6 results result NNS cord-296075-8axbkyyz 15 7 also also RB cord-296075-8axbkyyz 15 8 show show VBP cord-296075-8axbkyyz 15 9 that that IN cord-296075-8axbkyyz 15 10 cells cell NNS cord-296075-8axbkyyz 15 11 responsive responsive JJ cord-296075-8axbkyyz 15 12 to to IN cord-296075-8axbkyyz 15 13 both both DT cord-296075-8axbkyyz 15 14 of of IN cord-296075-8axbkyyz 15 15 the the DT cord-296075-8axbkyyz 15 16 previously previously RB cord-296075-8axbkyyz 15 17 identified identify VBN cord-296075-8axbkyyz 15 18 CNS CNS NNP cord-296075-8axbkyyz 15 19 - - HYPH cord-296075-8axbkyyz 15 20 derived derive VBN cord-296075-8axbkyyz 15 21 CD8+T cd8+t JJ cord-296075-8axbkyyz 15 22 cell cell NN cord-296075-8axbkyyz 15 23 epitopes epitope NNS cord-296075-8axbkyyz 15 24 are be VBP cord-296075-8axbkyyz 15 25 present present JJ cord-296075-8axbkyyz 15 26 in in IN cord-296075-8axbkyyz 15 27 the the DT cord-296075-8axbkyyz 15 28 infected infected JJ cord-296075-8axbkyyz 15 29 spleen spleen NN cord-296075-8axbkyyz 15 30 at at IN cord-296075-8axbkyyz 15 31 nearly nearly RB cord-296075-8axbkyyz 15 32 the the DT cord-296075-8axbkyyz 15 33 same same JJ cord-296075-8axbkyyz 15 34 frequency frequency NN cord-296075-8axbkyyz 15 35 . . . cord-296075-8axbkyyz 16 1 ( ( -LRB- cord-296075-8axbkyyz 16 2 26 26 CD cord-296075-8axbkyyz 16 3 ) ) -RRB- cord-296075-8axbkyyz 16 4 or or CC cord-296075-8axbkyyz 16 5 S s NN cord-296075-8axbkyyz 16 6 - - HYPH cord-296075-8axbkyyz 16 7 specific specific JJ cord-296075-8axbkyyz 16 8 immunogenic immunogenic JJ cord-296075-8axbkyyz 16 9 peptides peptide NNS cord-296075-8axbkyyz 16 10 S510 S510 NNP cord-296075-8axbkyyz 16 11 - - HYPH cord-296075-8axbkyyz 16 12 518 518 CD cord-296075-8axbkyyz 16 13 or or CC cord-296075-8axbkyyz 16 14 S598 S598 NNP cord-296075-8axbkyyz 16 15 - - HYPH cord-296075-8axbkyyz 16 16 605 605 CD cord-296075-8axbkyyz 17 1 ( ( -LRB- cord-296075-8axbkyyz 17 2 unpublished unpublished JJ cord-296075-8axbkyyz 17 3 observations observation NNS cord-296075-8axbkyyz 17 4 ) ) -RRB- cord-296075-8axbkyyz 17 5 in in IN cord-296075-8axbkyyz 17 6 direct direct JJ cord-296075-8axbkyyz 17 7 ex ex FW cord-296075-8axbkyyz 17 8 vivo vivo NN cord-296075-8axbkyyz 17 9 chronic chronic JJ cord-296075-8axbkyyz 17 10 demyelinating demyelinate VBG cord-296075-8axbkyyz 17 11 encephalomyelitis encephalomyelitis NN cord-296075-8axbkyyz 17 12 in in IN cord-296075-8axbkyyz 17 13 susceptible susceptible JJ cord-296075-8axbkyyz 17 14 CTL CTL NNP cord-296075-8axbkyyz 17 15 assays assay NNS cord-296075-8axbkyyz 17 16 using use VBG cord-296075-8axbkyyz 17 17 cells cell NNS cord-296075-8axbkyyz 17 18 isolated isolate VBN cord-296075-8axbkyyz 17 19 from from IN cord-296075-8axbkyyz 17 20 the the DT cord-296075-8axbkyyz 17 21 spleens spleen NNS cord-296075-8axbkyyz 17 22 of of IN cord-296075-8axbkyyz 17 23 mice mouse NNS cord-296075-8axbkyyz 17 24 mice mouse NNS cord-296075-8axbkyyz 17 25 and and CC cord-296075-8axbkyyz 17 26 rats rat NNS cord-296075-8axbkyyz 17 27 ( ( -LRB- cord-296075-8axbkyyz 17 28 3 3 CD cord-296075-8axbkyyz 17 29 - - SYM cord-296075-8axbkyyz 17 30 8 8 CD cord-296075-8axbkyyz 17 31 ) ) -RRB- cord-296075-8axbkyyz 17 32 . . . cord-296075-8axbkyyz 18 1 The the DT cord-296075-8axbkyyz 18 2 chronic chronic JJ cord-296075-8axbkyyz 18 3 disease disease NN cord-296075-8axbkyyz 18 4 results result VBZ cord-296075-8axbkyyz 18 5 either either CC cord-296075-8axbkyyz 18 6 with with IN cord-296075-8axbkyyz 18 7 acute acute JJ cord-296075-8axbkyyz 18 8 encephalitis encephalitis RB cord-296075-8axbkyyz 18 9 . . . cord-296075-8axbkyyz 19 1 Bergmann Bergmann NNP cord-296075-8axbkyyz 19 2 et et NNP cord-296075-8axbkyyz 19 3 al al NNP cord-296075-8axbkyyz 19 4 . . NNP cord-296075-8axbkyyz 19 5 , , , cord-296075-8axbkyyz 19 6 however however RB cord-296075-8axbkyyz 19 7 , , , cord-296075-8axbkyyz 19 8 were be VBD cord-296075-8axbkyyz 19 9 if if IN cord-296075-8axbkyyz 19 10 mice mouse NNS cord-296075-8axbkyyz 19 11 are be VBP cord-296075-8axbkyyz 19 12 infected infect VBN cord-296075-8axbkyyz 19 13 with with IN cord-296075-8axbkyyz 19 14 an an DT cord-296075-8axbkyyz 19 15 attenuated attenuated JJ cord-296075-8axbkyyz 19 16 variant variant NN cord-296075-8axbkyyz 19 17 of of IN cord-296075-8axbkyyz 19 18 MHV MHV NNP cord-296075-8axbkyyz 19 19 able able JJ cord-296075-8axbkyyz 19 20 to to TO cord-296075-8axbkyyz 19 21 isolate isolate VB cord-296075-8axbkyyz 19 22 S S NNP cord-296075-8axbkyyz 19 23 protein protein NN cord-296075-8axbkyyz 19 24 - - HYPH cord-296075-8axbkyyz 19 25 specific specific JJ cord-296075-8axbkyyz 19 26 CD8 CD8 NNP cord-296075-8axbkyyz 19 27 / / SYM cord-296075-8axbkyyz 19 28 T T NNP cord-296075-8axbkyyz 19 29 cell cell NN cord-296075-8axbkyyz 19 30 clones clone NNS cord-296075-8axbkyyz 19 31 from from IN cord-296075-8axbkyyz 19 32 or or CC cord-296075-8axbkyyz 19 33 if if IN cord-296075-8axbkyyz 19 34 they -PRON- PRP cord-296075-8axbkyyz 19 35 are be VBP cord-296075-8axbkyyz 19 36 protected protect VBN cord-296075-8axbkyyz 19 37 from from IN cord-296075-8axbkyyz 19 38 the the DT cord-296075-8axbkyyz 19 39 acute acute JJ cord-296075-8axbkyyz 19 40 encephalitis encephalitis RB cord-296075-8axbkyyz 19 41 by by IN cord-296075-8axbkyyz 19 42 a a DT cord-296075-8axbkyyz 19 43 the the DT cord-296075-8axbkyyz 19 44 spleens spleen NNS cord-296075-8axbkyyz 19 45 of of IN cord-296075-8axbkyyz 19 46 B6 b6 NN cord-296075-8axbkyyz 19 47 mice mouse NNS cord-296075-8axbkyyz 19 48 infected infect VBN cord-296075-8axbkyyz 19 49 intraperitoneally intraperitoneally RB cord-296075-8axbkyyz 19 50 with with IN cord-296075-8axbkyyz 19 51 a a DT cord-296075-8axbkyyz 19 52 passive passive JJ cord-296075-8axbkyyz 19 53 infusion infusion NN cord-296075-8axbkyyz 19 54 of of IN cord-296075-8axbkyyz 19 55 anti anti JJ cord-296075-8axbkyyz 19 56 - - JJ cord-296075-8axbkyyz 19 57 viral viral JJ cord-296075-8axbkyyz 19 58 antibodies antibody NNS cord-296075-8axbkyyz 19 59 , , , cord-296075-8axbkyyz 19 60 CD4 CD4 NNP cord-296075-8axbkyyz 19 61 / / SYM cord-296075-8axbkyyz 19 62 T T NNP cord-296075-8axbkyyz 19 63 cells cell NNS cord-296075-8axbkyyz 19 64 or or CC cord-296075-8axbkyyz 19 65 sublethal sublethal JJ cord-296075-8axbkyyz 19 66 dose dose NN cord-296075-8axbkyyz 19 67 of of IN cord-296075-8axbkyyz 19 68 virus virus NN cord-296075-8axbkyyz 19 69 . . . cord-296075-8axbkyyz 20 1 These these DT cord-296075-8axbkyyz 20 2 clones clone NNS cord-296075-8axbkyyz 20 3 only only RB cord-296075-8axbkyyz 20 4 recognized recognize VBD cord-296075-8axbkyyz 20 5 CD8 CD8 NNP cord-296075-8axbkyyz 20 6 / / SYM cord-296075-8axbkyyz 20 7 T T NNP cord-296075-8axbkyyz 20 8 cells cell NNS cord-296075-8axbkyyz 20 9 ( ( -LRB- cord-296075-8axbkyyz 20 10 6 6 CD cord-296075-8axbkyyz 20 11 , , , cord-296075-8axbkyyz 20 12 ( ( -LRB- cord-296075-8axbkyyz 20 13 9 9 LS cord-296075-8axbkyyz 20 14 ) ) -RRB- cord-296075-8axbkyyz 20 15 ( ( -LRB- cord-296075-8axbkyyz 20 16 10 10 CD cord-296075-8axbkyyz 20 17 ) ) -RRB- cord-296075-8axbkyyz 20 18 ( ( -LRB- cord-296075-8axbkyyz 20 19 11 11 CD cord-296075-8axbkyyz 20 20 ) ) -RRB- cord-296075-8axbkyyz 20 21 ( ( -LRB- cord-296075-8axbkyyz 20 22 12 12 CD cord-296075-8axbkyyz 20 23 ) ) -RRB- cord-296075-8axbkyyz 20 24 ( ( -LRB- cord-296075-8axbkyyz 20 25 13 13 CD cord-296075-8axbkyyz 20 26 ) ) -RRB- cord-296075-8axbkyyz 20 27 ( ( -LRB- cord-296075-8axbkyyz 20 28 14 14 CD cord-296075-8axbkyyz 20 29 ) ) -RRB- cord-296075-8axbkyyz 20 30 ( ( -LRB- cord-296075-8axbkyyz 20 31 15 15 CD cord-296075-8axbkyyz 20 32 ) ) -RRB- cord-296075-8axbkyyz 20 33 ( ( -LRB- cord-296075-8axbkyyz 20 34 16 16 CD cord-296075-8axbkyyz 20 35 ) ) -RRB- cord-296075-8axbkyyz 20 36 ( ( -LRB- cord-296075-8axbkyyz 20 37 17 17 CD cord-296075-8axbkyyz 20 38 ) ) -RRB- cord-296075-8axbkyyz 20 39 ( ( -LRB- cord-296075-8axbkyyz 20 40 18 18 CD cord-296075-8axbkyyz 20 41 ) ) -RRB- cord-296075-8axbkyyz 20 42 ( ( -LRB- cord-296075-8axbkyyz 20 43 19 19 CD cord-296075-8axbkyyz 20 44 ) ) -RRB- cord-296075-8axbkyyz 20 45 ( ( -LRB- cord-296075-8axbkyyz 20 46 20 20 CD cord-296075-8axbkyyz 20 47 ) ) -RRB- cord-296075-8axbkyyz 20 48 ( ( -LRB- cord-296075-8axbkyyz 20 49 21 21 CD cord-296075-8axbkyyz 20 50 ) ) -RRB- cord-296075-8axbkyyz 20 51 ( ( -LRB- cord-296075-8axbkyyz 20 52 22 22 CD cord-296075-8axbkyyz 20 53 ) ) -RRB- cord-296075-8axbkyyz 20 54 . . . cord-296075-8axbkyyz 21 1 This this DT cord-296075-8axbkyyz 21 2 chronic chronic JJ cord-296075-8axbkyyz 21 3 neurological neurological JJ cord-296075-8axbkyyz 21 4 disease disease NN cord-296075-8axbkyyz 21 5 one one CD cord-296075-8axbkyyz 21 6 of of IN cord-296075-8axbkyyz 21 7 the the DT cord-296075-8axbkyyz 21 8 two two CD cord-296075-8axbkyyz 21 9 epitopes epitope NNS cord-296075-8axbkyyz 21 10 which which WDT cord-296075-8axbkyyz 21 11 we -PRON- PRP cord-296075-8axbkyyz 21 12 identified identify VBD cord-296075-8axbkyyz 21 13 in in IN cord-296075-8axbkyyz 21 14 the the DT cord-296075-8axbkyyz 21 15 direct direct JJ cord-296075-8axbkyyz 21 16 has have VBZ cord-296075-8axbkyyz 21 17 been be VBN cord-296075-8axbkyyz 21 18 studied study VBN cord-296075-8axbkyyz 21 19 as as IN cord-296075-8axbkyyz 21 20 an an DT cord-296075-8axbkyyz 21 21 animal animal NN cord-296075-8axbkyyz 21 22 model model NN cord-296075-8axbkyyz 21 23 of of IN cord-296075-8axbkyyz 21 24 human human JJ cord-296075-8axbkyyz 21 25 demyex demyex NNP cord-296075-8axbkyyz 21 26 vivo vivo NNP cord-296075-8axbkyyz 21 27 CTL CTL NNP cord-296075-8axbkyyz 21 28 assays assay NNS cord-296075-8axbkyyz 21 29 . . . cord-296075-8axbkyyz 22 1 The the DT cord-296075-8axbkyyz 22 2 same same JJ cord-296075-8axbkyyz 22 3 results result NNS cord-296075-8axbkyyz 22 4 were be VBD cord-296075-8axbkyyz 22 5 obtained obtain VBN cord-296075-8axbkyyz 22 6 elinating elinate VBG cord-296075-8axbkyyz 22 7 disease disease NN cord-296075-8axbkyyz 22 8 , , , cord-296075-8axbkyyz 22 9 including include VBG cord-296075-8axbkyyz 22 10 multiple multiple JJ cord-296075-8axbkyyz 22 11 sclerosis sclerosis NN cord-296075-8axbkyyz 22 12 . . . cord-296075-8axbkyyz 23 1 when when WRB cord-296075-8axbkyyz 23 2 spleen spleen NN cord-296075-8axbkyyz 23 3 cells cell NNS cord-296075-8axbkyyz 23 4 were be VBD cord-296075-8axbkyyz 23 5 analyzed analyze VBN cord-296075-8axbkyyz 23 6 in in IN cord-296075-8axbkyyz 23 7 CTL CTL NNP cord-296075-8axbkyyz 23 8 assays assay NNS cord-296075-8axbkyyz 23 9 after after IN cord-296075-8axbkyyz 23 10 Both Both NNP cord-296075-8axbkyyz 23 11 CD4 CD4 NNP cord-296075-8axbkyyz 23 12 / / , cord-296075-8axbkyyz 23 13 and and CC cord-296075-8axbkyyz 23 14 CD8 CD8 NNP cord-296075-8axbkyyz 23 15 / / SYM cord-296075-8axbkyyz 23 16 T T NNP cord-296075-8axbkyyz 23 17 cells cell NNS cord-296075-8axbkyyz 23 18 are be VBP cord-296075-8axbkyyz 23 19 required require VBN cord-296075-8axbkyyz 23 20 for for IN cord-296075-8axbkyyz 23 21 virus virus NN cord-296075-8axbkyyz 23 22 secondary secondary JJ cord-296075-8axbkyyz 23 23 stimulation stimulation NN cord-296075-8axbkyyz 23 24 in in IN cord-296075-8axbkyyz 23 25 vitro vitro FW cord-296075-8axbkyyz 23 26 with with IN cord-296075-8axbkyyz 23 27 MHV mhv NN cord-296075-8axbkyyz 23 28 - - HYPH cord-296075-8axbkyyz 23 29 infected infect VBN cord-296075-8axbkyyz 23 30 spleen spleen NN cord-296075-8axbkyyz 23 31 clearance clearance NN cord-296075-8axbkyyz 23 32 ( ( -LRB- cord-296075-8axbkyyz 23 33 23 23 CD cord-296075-8axbkyyz 23 34 - - SYM cord-296075-8axbkyyz 23 35 25 25 CD cord-296075-8axbkyyz 23 36 ) ) -RRB- cord-296075-8axbkyyz 23 37 . . . cord-296075-8axbkyyz 24 1 Target target NN cord-296075-8axbkyyz 24 2 proteins protein NNS cord-296075-8axbkyyz 24 3 for for IN cord-296075-8axbkyyz 24 4 CD8 CD8 NNP cord-296075-8axbkyyz 24 5 / / SYM cord-296075-8axbkyyz 24 6 T T NNP cord-296075-8axbkyyz 24 7 cell cell NN cord-296075-8axbkyyz 24 8 cytocells cytocell NNS cord-296075-8axbkyyz 24 9 ( ( -LRB- cord-296075-8axbkyyz 24 10 2 2 CD cord-296075-8axbkyyz 24 11 ) ) -RRB- cord-296075-8axbkyyz 24 12 . . . cord-296075-8axbkyyz 25 1 toxicity toxicity NN cord-296075-8axbkyyz 25 2 have have VBP cord-296075-8axbkyyz 25 3 been be VBN cord-296075-8axbkyyz 25 4 identified identify VBN cord-296075-8axbkyyz 25 5 in in IN cord-296075-8axbkyyz 25 6 MHV MHV NNP cord-296075-8axbkyyz 25 7 - - HYPH cord-296075-8axbkyyz 25 8 JHM JHM NNP cord-296075-8axbkyyz 25 9 - - HYPH cord-296075-8axbkyyz 25 10 infected infect VBN cord-296075-8axbkyyz 25 11 BALB/ BALB/ NNP cord-296075-8axbkyyz 26 1 In in IN cord-296075-8axbkyyz 26 2 many many JJ cord-296075-8axbkyyz 26 3 cases case NNS cord-296075-8axbkyyz 26 4 , , , cord-296075-8axbkyyz 26 5 antigen antigen NN cord-296075-8axbkyyz 26 6 - - HYPH cord-296075-8axbkyyz 26 7 specific specific JJ cord-296075-8axbkyyz 26 8 cytotoxicity cytotoxicity NN cord-296075-8axbkyyz 26 9 by by IN cord-296075-8axbkyyz 26 10 cells cell NNS cord-296075-8axbkyyz 26 11 c c NN cord-296075-8axbkyyz 27 1 and and CC cord-296075-8axbkyyz 27 2 C57Bl/6 C57Bl/6 NNP cord-296075-8axbkyyz 27 3 ( ( -LRB- cord-296075-8axbkyyz 27 4 B6 b6 NN cord-296075-8axbkyyz 27 5 ) ) -RRB- cord-296075-8axbkyyz 27 6 mice mouse NNS cord-296075-8axbkyyz 27 7 . . . cord-296075-8axbkyyz 28 1 In in IN cord-296075-8axbkyyz 28 2 BALB BALB NNP cord-296075-8axbkyyz 28 3 / / SYM cord-296075-8axbkyyz 28 4 c c NN cord-296075-8axbkyyz 28 5 mice mouse NNS cord-296075-8axbkyyz 28 6 , , , cord-296075-8axbkyyz 28 7 the the DT cord-296075-8axbkyyz 28 8 majority majority NN cord-296075-8axbkyyz 28 9 of of IN cord-296075-8axbkyyz 28 10 primed prime VBN cord-296075-8axbkyyz 28 11 in in IN cord-296075-8axbkyyz 28 12 vivo vivo NN cord-296075-8axbkyyz 28 13 can can MD cord-296075-8axbkyyz 28 14 only only RB cord-296075-8axbkyyz 28 15 be be VB cord-296075-8axbkyyz 28 16 demonstrated demonstrate VBN cord-296075-8axbkyyz 28 17 after after IN cord-296075-8axbkyyz 28 18 secondary secondary JJ cord-296075-8axbkyyz 28 19 the the DT cord-296075-8axbkyyz 28 20 CTL CTL NNP cord-296075-8axbkyyz 28 21 activity activity NN cord-296075-8axbkyyz 28 22 is be VBZ cord-296075-8axbkyyz 28 23 directed direct VBN cord-296075-8axbkyyz 28 24 against against IN cord-296075-8axbkyyz 28 25 the the DT cord-296075-8axbkyyz 28 26 nucleocapsid nucleocapsid NN cord-296075-8axbkyyz 28 27 ( ( -LRB- cord-296075-8axbkyyz 28 28 N N NNP cord-296075-8axbkyyz 28 29 ) ) -RRB- cord-296075-8axbkyyz 28 30 in in IN cord-296075-8axbkyyz 28 31 vitro vitro FW cord-296075-8axbkyyz 28 32 stimulation stimulation NN cord-296075-8axbkyyz 28 33 with with IN cord-296075-8axbkyyz 28 34 antigen antigen NN cord-296075-8axbkyyz 28 35 . . . cord-296075-8axbkyyz 29 1 Conversely conversely RB cord-296075-8axbkyyz 29 2 , , , cord-296075-8axbkyyz 29 3 there there EX cord-296075-8axbkyyz 29 4 are be VBP cord-296075-8axbkyyz 29 5 protein protein NN cord-296075-8axbkyyz 29 6 , , , cord-296075-8axbkyyz 29 7 whereas whereas IN cord-296075-8axbkyyz 29 8 in in IN cord-296075-8axbkyyz 29 9 B6 b6 NN cord-296075-8axbkyyz 29 10 mice mouse NNS cord-296075-8axbkyyz 29 11 , , , cord-296075-8axbkyyz 29 12 the the DT cord-296075-8axbkyyz 29 13 S S NNP cord-296075-8axbkyyz 29 14 glycoprotein glycoprotein NN cord-296075-8axbkyyz 29 15 is be VBZ cord-296075-8axbkyyz 29 16 the the DT cord-296075-8axbkyyz 29 17 no no DT cord-296075-8axbkyyz 29 18 reports report NNS cord-296075-8axbkyyz 29 19 identifying identify VBG cord-296075-8axbkyyz 29 20 epitopes epitope NNS cord-296075-8axbkyyz 29 21 which which WDT cord-296075-8axbkyyz 29 22 are be VBP cord-296075-8axbkyyz 29 23 observed observe VBN cord-296075-8axbkyyz 29 24 in in IN cord-296075-8axbkyyz 29 25 predominant predominant JJ cord-296075-8axbkyyz 29 26 target target NN cord-296075-8axbkyyz 29 27 ( ( -LRB- cord-296075-8axbkyyz 29 28 26 26 CD cord-296075-8axbkyyz 29 29 , , , cord-296075-8axbkyyz 29 30 27 27 CD cord-296075-8axbkyyz 29 31 ) ) -RRB- cord-296075-8axbkyyz 29 32 . . . cord-296075-8axbkyyz 30 1 Using use VBG cord-296075-8axbkyyz 30 2 cells cell NNS cord-296075-8axbkyyz 30 3 isolated isolate VBN cord-296075-8axbkyyz 30 4 from from IN cord-296075-8axbkyyz 30 5 the the DT cord-296075-8axbkyyz 30 6 primary primary JJ cord-296075-8axbkyyz 30 7 but but CC cord-296075-8axbkyyz 30 8 not not RB cord-296075-8axbkyyz 30 9 secondary secondary JJ cord-296075-8axbkyyz 30 10 cytotoxic cytotoxic JJ cord-296075-8axbkyyz 30 11 T t NN cord-296075-8axbkyyz 30 12 cell cell NN cord-296075-8axbkyyz 30 13 assays assay NNS cord-296075-8axbkyyz 30 14 . . . cord-296075-8axbkyyz 31 1 The the DT cord-296075-8axbkyyz 31 2 CNS CNS NNP cord-296075-8axbkyyz 31 3 of of IN cord-296075-8axbkyyz 31 4 B6 b6 NN cord-296075-8axbkyyz 31 5 mice mouse NNS cord-296075-8axbkyyz 31 6 with with IN cord-296075-8axbkyyz 31 7 acute acute JJ cord-296075-8axbkyyz 31 8 encephalitis encephalitis RB cord-296075-8axbkyyz 31 9 and and CC cord-296075-8axbkyyz 31 10 analyzed analyze VBD cord-296075-8axbkyyz 31 11 results result NNS cord-296075-8axbkyyz 31 12 described describe VBN cord-296075-8axbkyyz 31 13 above above RB cord-296075-8axbkyyz 31 14 , , , cord-296075-8axbkyyz 31 15 therefore therefore RB cord-296075-8axbkyyz 31 16 , , , cord-296075-8axbkyyz 31 17 would would MD cord-296075-8axbkyyz 31 18 be be VB cord-296075-8axbkyyz 31 19 most most RBS cord-296075-8axbkyyz 31 20 condirectly condirectly RB cord-296075-8axbkyyz 31 21 ex ex NN cord-296075-8axbkyyz 31 22 vivo vivo NN cord-296075-8axbkyyz 31 23 in in IN cord-296075-8axbkyyz 31 24 cytotoxicity cytotoxicity NN cord-296075-8axbkyyz 31 25 assays assay NNS cord-296075-8axbkyyz 31 26 , , , cord-296075-8axbkyyz 31 27 we -PRON- PRP cord-296075-8axbkyyz 31 28 identified identify VBD cord-296075-8axbkyyz 31 29 two two CD cord-296075-8axbkyyz 31 30 sistent sistent NN cord-296075-8axbkyyz 31 31 with with IN cord-296075-8axbkyyz 31 32 different different JJ cord-296075-8axbkyyz 31 33 epitope epitope NN cord-296075-8axbkyyz 31 34 recognition recognition NN cord-296075-8axbkyyz 31 35 between between IN cord-296075-8axbkyyz 31 36 efimmunogenic efimmunogenic NNP cord-296075-8axbkyyz 31 37 CD8 CD8 NNP cord-296075-8axbkyyz 31 38 / / SYM cord-296075-8axbkyyz 31 39 T T NNP cord-296075-8axbkyyz 31 40 cell cell NN cord-296075-8axbkyyz 31 41 epitopes epitope NNS cord-296075-8axbkyyz 31 42 within within IN cord-296075-8axbkyyz 31 43 the the DT cord-296075-8axbkyyz 31 44 S S NNP cord-296075-8axbkyyz 31 45 protein protein NN cord-296075-8axbkyyz 31 46 fectors fector NNS cord-296075-8axbkyyz 31 47 harvested harvest VBN cord-296075-8axbkyyz 31 48 from from IN cord-296075-8axbkyyz 31 49 peripheral peripheral JJ cord-296075-8axbkyyz 31 50 lymphoid lymphoid JJ cord-296075-8axbkyyz 31 51 tissue tissue NN cord-296075-8axbkyyz 31 52 and and CC cord-296075-8axbkyyz 31 53 ( ( -LRB- cord-296075-8axbkyyz 31 54 1 1 CD cord-296075-8axbkyyz 31 55 ) ) -RRB- cord-296075-8axbkyyz 31 56 . . . cord-296075-8axbkyyz 32 1 In in IN cord-296075-8axbkyyz 32 2 contrast contrast NN cord-296075-8axbkyyz 32 3 to to IN cord-296075-8axbkyyz 32 4 these these DT cord-296075-8axbkyyz 32 5 results result NNS cord-296075-8axbkyyz 32 6 , , , cord-296075-8axbkyyz 32 7 we -PRON- PRP cord-296075-8axbkyyz 32 8 could could MD cord-296075-8axbkyyz 32 9 not not RB cord-296075-8axbkyyz 32 10 identify identify VB cord-296075-8axbkyyz 32 11 a a DT cord-296075-8axbkyyz 32 12 those those DT cord-296075-8axbkyyz 32 13 harvested harvest VBN cord-296075-8axbkyyz 32 14 from from IN cord-296075-8axbkyyz 32 15 the the DT cord-296075-8axbkyyz 32 16 site site NN cord-296075-8axbkyyz 32 17 of of IN cord-296075-8axbkyyz 32 18 inflammation inflammation NN cord-296075-8axbkyyz 32 19 , , , cord-296075-8axbkyyz 32 20 the the DT cord-296075-8axbkyyz 32 21 brain brain NN cord-296075-8axbkyyz 32 22 . . . cord-296075-8axbkyyz 33 1 significant significant JJ cord-296075-8axbkyyz 33 2 amount amount NN cord-296075-8axbkyyz 33 3 of of IN cord-296075-8axbkyyz 33 4 CTL CTL NNP cord-296075-8axbkyyz 33 5 activity activity NN cord-296075-8axbkyyz 33 6 against against IN cord-296075-8axbkyyz 33 7 the the DT cord-296075-8axbkyyz 33 8 S S NNP cord-296075-8axbkyyz 33 9 protein protein NN cord-296075-8axbkyyz 34 1 Alternatively alternatively RB cord-296075-8axbkyyz 34 2 , , , cord-296075-8axbkyyz 34 3 insufficient insufficient JJ cord-296075-8axbkyyz 34 4 presentation presentation NN cord-296075-8axbkyyz 34 5 of of IN cord-296075-8axbkyyz 34 6 the the DT cord-296075-8axbkyyz 34 7 H-2 H-2 NNP cord-296075-8axbkyyz 34 8 K K NNP cord-296075-8axbkyyz 34 9 b b NN cord-296075-8axbkyyz 34 10 -restricted -restricted JJ cord-296075-8axbkyyz 34 11 epitope epitope NN cord-296075-8axbkyyz 34 12 in in IN cord-296075-8axbkyyz 34 13 vitro vitro FW cord-296075-8axbkyyz 34 14 and and CC cord-296075-8axbkyyz 34 15 consequent consequent JJ cord-296075-8axbkyyz 34 16 inefficient inefficient JJ cord-296075-8axbkyyz 34 17 expansion expansion NN cord-296075-8axbkyyz 34 18 of of IN cord-296075-8axbkyyz 34 19 lymphocytes lymphocyte NNS cord-296075-8axbkyyz 34 20 primed prime VBN cord-296075-8axbkyyz 34 21 in in IN cord-296075-8axbkyyz 34 22 vivo vivo NN cord-296075-8axbkyyz 34 23 to to TO cord-296075-8axbkyyz 34 24 respond respond VB cord-296075-8axbkyyz 34 25 to to IN cord-296075-8axbkyyz 34 26 this this DT cord-296075-8axbkyyz 34 27 To to TO cord-296075-8axbkyyz 34 28 determine determine VB cord-296075-8axbkyyz 34 29 if if IN cord-296075-8axbkyyz 34 30 inadequate inadequate JJ cord-296075-8axbkyyz 34 31 presentation presentation NN cord-296075-8axbkyyz 34 32 of of IN cord-296075-8axbkyyz 34 33 the the DT cord-296075-8axbkyyz 34 34 H-2 H-2 NNP cord-296075-8axbkyyz 34 35 K K NNP cord-296075-8axbkyyz 34 36 brestricted brestricte VBN cord-296075-8axbkyyz 34 37 epitope epitope NN cord-296075-8axbkyyz 34 38 could could MD cord-296075-8axbkyyz 34 39 be be VB cord-296075-8axbkyyz 34 40 overcome overcome VBN cord-296075-8axbkyyz 34 41 by by IN cord-296075-8axbkyyz 34 42 using use VBG cord-296075-8axbkyyz 34 43 a a DT cord-296075-8axbkyyz 34 44 different different JJ cord-296075-8axbkyyz 34 45 source source NN cord-296075-8axbkyyz 34 46 of of IN cord-296075-8axbkyyz 34 47 antigen antigen NN cord-296075-8axbkyyz 34 48 for for IN cord-296075-8axbkyyz 34 49 stimulation stimulation NN cord-296075-8axbkyyz 34 50 , , , cord-296075-8axbkyyz 34 51 two two CD cord-296075-8axbkyyz 34 52 alternative alternative JJ cord-296075-8axbkyyz 34 53 approaches approach NNS cord-296075-8axbkyyz 34 54 were be VBD cord-296075-8axbkyyz 34 55 tried try VBN cord-296075-8axbkyyz 34 56 . . . cord-296075-8axbkyyz 35 1 First first RB cord-296075-8axbkyyz 35 2 , , , cord-296075-8axbkyyz 35 3 irradiated irradiate VBN cord-296075-8axbkyyz 35 4 ( ( -LRB- cord-296075-8axbkyyz 35 5 9000 9000 CD cord-296075-8axbkyyz 35 6 rad rad NN cord-296075-8axbkyyz 35 7 ) ) -RRB- cord-296075-8axbkyyz 35 8 , , , cord-296075-8axbkyyz 35 9 MHVinfected MHVinfected NNP cord-296075-8axbkyyz 35 10 MC57 MC57 NNP cord-296075-8axbkyyz 35 11 cells cell NNS cord-296075-8axbkyyz 35 12 ( ( -LRB- cord-296075-8axbkyyz 35 13 H-2 H-2 NNP cord-296075-8axbkyyz 35 14 b b NN cord-296075-8axbkyyz 35 15 ) ) -RRB- cord-296075-8axbkyyz 35 16 were be VBD cord-296075-8axbkyyz 35 17 used use VBN cord-296075-8axbkyyz 35 18 as as IN cord-296075-8axbkyyz 35 19 stimulators stimulator NNS cord-296075-8axbkyyz 35 20 . . . cord-296075-8axbkyyz 36 1 MC57 MC57 NNP cord-296075-8axbkyyz 36 2 cells cell NNS cord-296075-8axbkyyz 36 3 in in IN cord-296075-8axbkyyz 36 4 general general JJ cord-296075-8axbkyyz 36 5 are be VBP cord-296075-8axbkyyz 36 6 not not RB cord-296075-8axbkyyz 36 7 readily readily RB cord-296075-8axbkyyz 36 8 infected infect VBN cord-296075-8axbkyyz 36 9 by by IN cord-296075-8axbkyyz 36 10 MHV MHV NNP cord-296075-8axbkyyz 36 11 - - HYPH cord-296075-8axbkyyz 36 12 JHM JHM NNP cord-296075-8axbkyyz 36 13 ( ( -LRB- cord-296075-8axbkyyz 36 14 28 28 CD cord-296075-8axbkyyz 36 15 ) ) -RRB- cord-296075-8axbkyyz 36 16 , , , cord-296075-8axbkyyz 36 17 but but CC cord-296075-8axbkyyz 36 18 a a DT cord-296075-8axbkyyz 36 19 line line NN cord-296075-8axbkyyz 36 20 which which WDT cord-296075-8axbkyyz 36 21 was be VBD cord-296075-8axbkyyz 36 22 partially partially RB cord-296075-8axbkyyz 36 23 susceptible susceptible JJ cord-296075-8axbkyyz 36 24 to to IN cord-296075-8axbkyyz 36 25 the the DT cord-296075-8axbkyyz 36 26 virus virus NN cord-296075-8axbkyyz 36 27 ( ( -LRB- cord-296075-8axbkyyz 36 28 approximately approximately RB cord-296075-8axbkyyz 36 29 10 10 CD cord-296075-8axbkyyz 36 30 - - SYM cord-296075-8axbkyyz 36 31 20 20 CD cord-296075-8axbkyyz 36 32 % % NN cord-296075-8axbkyyz 36 33 of of IN cord-296075-8axbkyyz 36 34 the the DT cord-296075-8axbkyyz 36 35 cells cell NNS cord-296075-8axbkyyz 36 36 were be VBD cord-296075-8axbkyyz 36 37 positive positive JJ cord-296075-8axbkyyz 36 38 for for IN cord-296075-8axbkyyz 36 39 viral viral JJ cord-296075-8axbkyyz 36 40 antigen antigen NN cord-296075-8axbkyyz 36 41 in in IN cord-296075-8axbkyyz 36 42 an an DT cord-296075-8axbkyyz 36 43 immunofluorescence immunofluorescence NN cord-296075-8axbkyyz 36 44 assay assay NN cord-296075-8axbkyyz 36 45 ) ) -RRB- cord-296075-8axbkyyz 36 46 was be VBD cord-296075-8axbkyyz 36 47 developed develop VBN cord-296075-8axbkyyz 36 48 . . . cord-296075-8axbkyyz 37 1 When when WRB cord-296075-8axbkyyz 37 2 these these DT cord-296075-8axbkyyz 37 3 cells cell NNS cord-296075-8axbkyyz 37 4 were be VBD cord-296075-8axbkyyz 37 5 used use VBN cord-296075-8axbkyyz 37 6 to to TO cord-296075-8axbkyyz 37 7 stimulate stimulate VB cord-296075-8axbkyyz 37 8 control control NN cord-296075-8axbkyyz 37 9 ( ( -LRB- cord-296075-8axbkyyz 37 10 EL-4 EL-4 NNP cord-296075-8axbkyyz 37 11 ) ) -RRB- cord-296075-8axbkyyz 37 12 . . . cord-296075-8axbkyyz 38 1 The the DT cord-296075-8axbkyyz 38 2 average average JJ cord-296075-8axbkyyz 38 3 spontaneous spontaneous JJ cord-296075-8axbkyyz 38 4 release release NN cord-296075-8axbkyyz 38 5 for for IN cord-296075-8axbkyyz 38 6 EL-4 EL-4 NNP cord-296075-8axbkyyz 38 7 targets target NNS cord-296075-8axbkyyz 38 8 corresponded correspond VBD cord-296075-8axbkyyz 38 9 to to IN cord-296075-8axbkyyz 38 10 õ13 õ13 CD cord-296075-8axbkyyz 38 11 % % NN cord-296075-8axbkyyz 38 12 and and CC cord-296075-8axbkyyz 38 13 for for IN cord-296075-8axbkyyz 38 14 MC57 MC57 NNP cord-296075-8axbkyyz 38 15 cells cell NNS cord-296075-8axbkyyz 38 16 õ25 õ25 CD cord-296075-8axbkyyz 38 17 % % NN cord-296075-8axbkyyz 38 18 . . . cord-296075-8axbkyyz 39 1 Percentage percentage NN cord-296075-8axbkyyz 39 2 of of IN cord-296075-8axbkyyz 39 3 specific specific NN cord-296075-8axbkyyz 39 4 For for IN cord-296075-8axbkyyz 39 5 this this DT cord-296075-8axbkyyz 39 6 purpose purpose NN cord-296075-8axbkyyz 39 7 , , , cord-296075-8axbkyyz 39 8 splenocytes splenocytes NNP cord-296075-8axbkyyz 39 9 were be VBD cord-296075-8axbkyyz 39 10 harvested harvest VBN cord-296075-8axbkyyz 39 11 8 8 CD cord-296075-8axbkyyz 39 12 days day NNS cord-296075-8axbkyyz 39 13 release release NN cord-296075-8axbkyyz 39 14 was be VBD cord-296075-8axbkyyz 39 15 calculated calculate VBN cord-296075-8axbkyyz 39 16 as as IN cord-296075-8axbkyyz 39 17 described describe VBN cord-296075-8axbkyyz 39 18 previously previously RB cord-296075-8axbkyyz 39 19 ( ( -LRB- cord-296075-8axbkyyz 39 20 26 26 CD cord-296075-8axbkyyz 39 21 ) ) -RRB- cord-296075-8axbkyyz 39 22 . . . cord-296075-8axbkyyz 40 1 after after IN cord-296075-8axbkyyz 40 2 intraperitoneal intraperitoneal JJ cord-296075-8axbkyyz 40 3 inoculation inoculation NN cord-296075-8axbkyyz 40 4 and and CC cord-296075-8axbkyyz 40 5 restimulated restimulate VBN cord-296075-8axbkyyz 40 6 in in IN cord-296075-8axbkyyz 40 7 vitro vitro FW cord-296075-8axbkyyz 40 8 with with IN cord-296075-8axbkyyz 40 9 EL-4-S35 el-4-s35 NN cord-296075-8axbkyyz 40 10 cells cell NNS cord-296075-8axbkyyz 40 11 . . . cord-296075-8axbkyyz 41 1 When when WRB cord-296075-8axbkyyz 41 2 analyzed analyze VBN cord-296075-8axbkyyz 41 3 in in IN cord-296075-8axbkyyz 41 4 CTL CTL NNP cord-296075-8axbkyyz 41 5 assays assay NNS cord-296075-8axbkyyz 41 6 , , , cord-296075-8axbkyyz 41 7 these these DT cord-296075-8axbkyyz 41 8 cells cell NNS cord-296075-8axbkyyz 41 9 recognized recognize VBD cord-296075-8axbkyyz 41 10 the the DT cord-296075-8axbkyyz 41 11 H-2D H-2D NNP cord-296075-8axbkyyz 41 12 b b NN cord-296075-8axbkyyz 41 13 , , , cord-296075-8axbkyyz 41 14 but but CC cord-296075-8axbkyyz 41 15 not not RB cord-296075-8axbkyyz 41 16 the the DT cord-296075-8axbkyyz 41 17 H-2 H-2 NNP cord-296075-8axbkyyz 41 18 K K NNP cord-296075-8axbkyyz 41 19 b b NNP cord-296075-8axbkyyz 41 20 -restricted -restricte VBD cord-296075-8axbkyyz 41 21 stricted stricted JJ cord-296075-8axbkyyz 41 22 epitopes epitope NNS cord-296075-8axbkyyz 41 23 . . . cord-296075-8axbkyyz 42 1 Irradiated irradiate VBN cord-296075-8axbkyyz 42 2 splenocytes splenocyte NNS cord-296075-8axbkyyz 42 3 were be VBD cord-296075-8axbkyyz 42 4 coated coat VBN cord-296075-8axbkyyz 42 5 with with IN cord-296075-8axbkyyz 42 6 both both DT cord-296075-8axbkyyz 42 7 peptides peptide NNS cord-296075-8axbkyyz 42 8 at at IN cord-296075-8axbkyyz 42 9 a a DT cord-296075-8axbkyyz 42 10 concentration concentration NN cord-296075-8axbkyyz 42 11 of of IN cord-296075-8axbkyyz 42 12 5 5 CD cord-296075-8axbkyyz 42 13 mM mm CD cord-296075-8axbkyyz 42 14 each each DT cord-296075-8axbkyyz 42 15 , , , cord-296075-8axbkyyz 42 16 epitope epitope NN cord-296075-8axbkyyz 42 17 ( ( -LRB- cord-296075-8axbkyyz 42 18 Fig Fig NNP cord-296075-8axbkyyz 42 19 . . . cord-296075-8axbkyyz 42 20 1B 1b CD cord-296075-8axbkyyz 42 21 ) ) -RRB- cord-296075-8axbkyyz 42 22 . . . cord-296075-8axbkyyz 43 1 The the DT cord-296075-8axbkyyz 43 2 results result NNS cord-296075-8axbkyyz 43 3 from from IN cord-296075-8axbkyyz 43 4 these these DT cord-296075-8axbkyyz 43 5 experiments experiment NNS cord-296075-8axbkyyz 43 6 using use VBG cord-296075-8axbkyyz 43 7 two two CD cord-296075-8axbkyyz 43 8 different different JJ cord-296075-8axbkyyz 43 9 types type NNS cord-296075-8axbkyyz 43 10 of of IN cord-296075-8axbkyyz 43 11 cells cell NNS cord-296075-8axbkyyz 43 12 expressing express VBG cord-296075-8axbkyyz 43 13 S S NNP cord-296075-8axbkyyz 43 14 protein protein NN cord-296075-8axbkyyz 43 15 washed wash VBD cord-296075-8axbkyyz 43 16 , , , cord-296075-8axbkyyz 43 17 and and CC cord-296075-8axbkyyz 43 18 added add VBD cord-296075-8axbkyyz 43 19 to to IN cord-296075-8axbkyyz 43 20 bulk bulk JJ cord-296075-8axbkyyz 43 21 cultures culture NNS cord-296075-8axbkyyz 43 22 of of IN cord-296075-8axbkyyz 43 23 spleen spleen NN cord-296075-8axbkyyz 43 24 cells cell NNS cord-296075-8axbkyyz 43 25 from from IN cord-296075-8axbkyyz 43 26 MHV mhv NN cord-296075-8axbkyyz 43 27 - - HYPH cord-296075-8axbkyyz 43 28 infected infect VBN cord-296075-8axbkyyz 43 29 mice mouse NNS cord-296075-8axbkyyz 43 30 . . . cord-296075-8axbkyyz 44 1 As as IN cord-296075-8axbkyyz 44 2 shown show VBN cord-296075-8axbkyyz 44 3 in in IN cord-296075-8axbkyyz 44 4 Fig Fig NNP cord-296075-8axbkyyz 44 5 . . NNP cord-296075-8axbkyyz 44 6 2 2 CD cord-296075-8axbkyyz 44 7 , , , cord-296075-8axbkyyz 44 8 splenocytes splenocytes NNP cord-296075-8axbkyyz 44 9 stim stim NN cord-296075-8axbkyyz 44 10 - - HYPH cord-296075-8axbkyyz 44 11 as as IN cord-296075-8axbkyyz 44 12 stimulators stimulator NNS cord-296075-8axbkyyz 44 13 are be VBP cord-296075-8axbkyyz 44 14 the the DT cord-296075-8axbkyyz 44 15 same same JJ cord-296075-8axbkyyz 44 16 as as IN cord-296075-8axbkyyz 44 17 those those DT cord-296075-8axbkyyz 44 18 obtained obtain VBN cord-296075-8axbkyyz 44 19 by by IN cord-296075-8axbkyyz 44 20 Bergmann Bergmann NNP cord-296075-8axbkyyz 44 21 et et NNP cord-296075-8axbkyyz 44 22 al al NNP cord-296075-8axbkyyz 44 23 . . . cord-296075-8axbkyyz 45 1 using use VBG cord-296075-8axbkyyz 45 2 MHV MHV NNP cord-296075-8axbkyyz 45 3 - - HYPH cord-296075-8axbkyyz 45 4 JHM JHM NNP cord-296075-8axbkyyz 45 5 - - HYPH cord-296075-8axbkyyz 45 6 infected infect VBN cord-296075-8axbkyyz 45 7 syngeneic syngeneic NNS cord-296075-8axbkyyz 45 8 spleen spleen NNS cord-296075-8axbkyyz 45 9 ulated ulate VBN cord-296075-8axbkyyz 45 10 in in IN cord-296075-8axbkyyz 45 11 vitro vitro FW cord-296075-8axbkyyz 45 12 with with IN cord-296075-8axbkyyz 45 13 both both DT cord-296075-8axbkyyz 45 14 peptides peptide NNS cord-296075-8axbkyyz 45 15 for for IN cord-296075-8axbkyyz 45 16 5 5 CD cord-296075-8axbkyyz 45 17 days day NNS cord-296075-8axbkyyz 45 18 were be VBD cord-296075-8axbkyyz 45 19 able able JJ cord-296075-8axbkyyz 45 20 to to TO cord-296075-8axbkyyz 45 21 efficiently efficiently RB cord-296075-8axbkyyz 45 22 lyse lyse VB cord-296075-8axbkyyz 45 23 targets target NNS cord-296075-8axbkyyz 45 24 coated coat VBN cord-296075-8axbkyyz 45 25 with with IN cord-296075-8axbkyyz 45 26 either either DT cord-296075-8axbkyyz 45 27 peptide peptide NN cord-296075-8axbkyyz 45 28 in in IN cord-296075-8axbkyyz 45 29 cells cell NNS cord-296075-8axbkyyz 45 30 . . . cord-296075-8axbkyyz 46 1 They -PRON- PRP cord-296075-8axbkyyz 46 2 showed show VBD cord-296075-8axbkyyz 46 3 that that IN cord-296075-8axbkyyz 46 4 when when WRB cord-296075-8axbkyyz 46 5 S S NNP cord-296075-8axbkyyz 46 6 protein protein NN cord-296075-8axbkyyz 46 7 was be VBD cord-296075-8axbkyyz 46 8 processed process VBN cord-296075-8axbkyyz 46 9 endogenously endogenously RB cord-296075-8axbkyyz 46 10 , , , cord-296075-8axbkyyz 46 11 the the DT cord-296075-8axbkyyz 46 12 H-2 H-2 NNP cord-296075-8axbkyyz 46 13 K K NNP cord-296075-8axbkyyz 46 14 b b NN cord-296075-8axbkyyz 46 15 -restricted -restricted JJ cord-296075-8axbkyyz 46 16 epitope epitope NN cord-296075-8axbkyyz 46 17 was be VBD cord-296075-8axbkyyz 46 18 not not RB cord-296075-8axbkyyz 46 19 rec rec NN cord-296075-8axbkyyz 46 20 - - JJ cord-296075-8axbkyyz 46 21 secondary secondary JJ cord-296075-8axbkyyz 46 22 cytotoxicity cytotoxicity NN cord-296075-8axbkyyz 46 23 assays assay NNS cord-296075-8axbkyyz 46 24 . . . cord-296075-8axbkyyz 47 1 These these DT cord-296075-8axbkyyz 47 2 results result NNS cord-296075-8axbkyyz 47 3 suggested suggest VBD cord-296075-8axbkyyz 47 4 that that IN cord-296075-8axbkyyz 47 5 both both DT cord-296075-8axbkyyz 47 6 epitopes epitope NNS cord-296075-8axbkyyz 47 7 were be VBD cord-296075-8axbkyyz 47 8 rec rec NN cord-296075-8axbkyyz 47 9 - - VBN cord-296075-8axbkyyz 47 10 ognized ognize VBN cord-296075-8axbkyyz 47 11 by by IN cord-296075-8axbkyyz 47 12 spleen spleen NN cord-296075-8axbkyyz 47 13 - - HYPH cord-296075-8axbkyyz 47 14 derived derive VBN cord-296075-8axbkyyz 47 15 lymphocytes lymphocyte NNS cord-296075-8axbkyyz 47 16 in in IN cord-296075-8axbkyyz 47 17 secondary secondary JJ cord-296075-8axbkyyz 47 18 CTL CTL NNP cord-296075-8axbkyyz 47 19 assays assay NNS cord-296075-8axbkyyz 47 20 . . . cord-296075-8axbkyyz 48 1 ognized ognize VBN cord-296075-8axbkyyz 48 2 efficiently efficiently RB cord-296075-8axbkyyz 48 3 in in IN cord-296075-8axbkyyz 48 4 the the DT cord-296075-8axbkyyz 48 5 mouse mouse NN cord-296075-8axbkyyz 48 6 and and CC cord-296075-8axbkyyz 48 7 that that IN cord-296075-8axbkyyz 48 8 stimulation stimulation NN cord-296075-8axbkyyz 48 9 in in IN cord-296075-8axbkyyz 48 10 vitro vitro FW cord-296075-8axbkyyz 48 11 was be VBD cord-296075-8axbkyyz 48 12 inefficient inefficient JJ cord-296075-8axbkyyz 48 13 in in IN cord-296075-8axbkyyz 48 14 the the DT cord-296075-8axbkyyz 48 15 case case NN cord-296075-8axbkyyz 48 16 of of IN cord-296075-8axbkyyz 48 17 the the DT cord-296075-8axbkyyz 48 18 H-2 H-2 NNP cord-296075-8axbkyyz 48 19 K K NNP cord-296075-8axbkyyz 48 20 b b NNP cord-296075-8axbkyyz 48 21 -restricted -restricte VBD cord-296075-8axbkyyz 49 1 The the DT cord-296075-8axbkyyz 49 2 results result NNS cord-296075-8axbkyyz 49 3 presented present VBN cord-296075-8axbkyyz 49 4 thus thus RB cord-296075-8axbkyyz 49 5 far far RB cord-296075-8axbkyyz 49 6 are be VBP cord-296075-8axbkyyz 49 7 consistent consistent JJ cord-296075-8axbkyyz 49 8 with with IN cord-296075-8axbkyyz 49 9 inefficient inefficient JJ cord-296075-8axbkyyz 49 10 presentation presentation NN cord-296075-8axbkyyz 49 11 of of IN cord-296075-8axbkyyz 49 12 the the DT cord-296075-8axbkyyz 49 13 H-2 H-2 NNP cord-296075-8axbkyyz 49 14 K K NNP cord-296075-8axbkyyz 49 15 b b NN cord-296075-8axbkyyz 49 16 -restricted -restricted JJ cord-296075-8axbkyyz 49 17 epitope epitope NN cord-296075-8axbkyyz 49 18 either either CC cord-296075-8axbkyyz 49 19 epitope epitope NN cord-296075-8axbkyyz 49 20 . . . cord-296075-8axbkyyz 50 1 It -PRON- PRP cord-296075-8axbkyyz 50 2 was be VBD cord-296075-8axbkyyz 50 3 not not RB cord-296075-8axbkyyz 50 4 possible possible JJ cord-296075-8axbkyyz 50 5 from from IN cord-296075-8axbkyyz 50 6 these these DT cord-296075-8axbkyyz 50 7 secondary secondary JJ cord-296075-8axbkyyz 50 8 CTL CTL NNP cord-296075-8axbkyyz 50 9 assays assay NNS cord-296075-8axbkyyz 50 10 using use VBG cord-296075-8axbkyyz 50 11 bulk bulk JJ cord-296075-8axbkyyz 50 12 cultures culture NNS cord-296075-8axbkyyz 50 13 to to TO cord-296075-8axbkyyz 50 14 determine determine VB cord-296075-8axbkyyz 50 15 if if IN cord-296075-8axbkyyz 50 16 there there EX cord-296075-8axbkyyz 50 17 were be VBD cord-296075-8axbkyyz 50 18 in in IN cord-296075-8axbkyyz 50 19 vivo vivo NN cord-296075-8axbkyyz 50 20 during during IN cord-296075-8axbkyyz 50 21 the the DT cord-296075-8axbkyyz 50 22 primary primary JJ cord-296075-8axbkyyz 50 23 response response NN cord-296075-8axbkyyz 50 24 or or CC cord-296075-8axbkyyz 50 25 later later RB cord-296075-8axbkyyz 50 26 in in IN cord-296075-8axbkyyz 50 27 vitro vitro FW cord-296075-8axbkyyz 50 28 . . . cord-296075-8axbkyyz 51 1 Stimulation stimulation NN cord-296075-8axbkyyz 51 2 with with IN cord-296075-8axbkyyz 51 3 exogenous exogenous JJ cord-296075-8axbkyyz 51 4 peptide peptide NN cord-296075-8axbkyyz 51 5 should should MD cord-296075-8axbkyyz 51 6 circumvent circumvent VB cord-296075-8axbkyyz 51 7 diffi diffi JJ cord-296075-8axbkyyz 51 8 - - HYPH cord-296075-8axbkyyz 51 9 quantitative quantitative JJ cord-296075-8axbkyyz 51 10 differences difference NNS cord-296075-8axbkyyz 51 11 in in IN cord-296075-8axbkyyz 51 12 the the DT cord-296075-8axbkyyz 51 13 number number NN cord-296075-8axbkyyz 51 14 of of IN cord-296075-8axbkyyz 51 15 CD8 CD8 NNP cord-296075-8axbkyyz 51 16 / / SYM cord-296075-8axbkyyz 51 17 T T NNP cord-296075-8axbkyyz 51 18 cells cell NNS cord-296075-8axbkyyz 51 19 responding respond VBG cord-296075-8axbkyyz 51 20 in in IN cord-296075-8axbkyyz 51 21 vivo vivo NN cord-296075-8axbkyyz 51 22 to to IN cord-296075-8axbkyyz 51 23 the the DT cord-296075-8axbkyyz 51 24 two two CD cord-296075-8axbkyyz 51 25 epitopes epitope NNS cord-296075-8axbkyyz 51 26 . . . cord-296075-8axbkyyz 52 1 Such such JJ cord-296075-8axbkyyz 52 2 quantitative quantitative JJ cord-296075-8axbkyyz 52 3 culties cultie NNS cord-296075-8axbkyyz 52 4 associated associate VBN cord-296075-8axbkyyz 52 5 with with IN cord-296075-8axbkyyz 52 6 presentation presentation NN cord-296075-8axbkyyz 52 7 of of IN cord-296075-8axbkyyz 52 8 a a DT cord-296075-8axbkyyz 52 9 suboptimal suboptimal JJ cord-296075-8axbkyyz 52 10 concentration concentration NN cord-296075-8axbkyyz 52 11 of of IN cord-296075-8axbkyyz 52 12 the the DT cord-296075-8axbkyyz 52 13 H-2 H-2 NNP cord-296075-8axbkyyz 52 14 K K NNP cord-296075-8axbkyyz 52 15 b b NN cord-296075-8axbkyyz 52 16 -restricted -restricted JJ cord-296075-8axbkyyz 52 17 epitope epitope NN cord-296075-8axbkyyz 52 18 in in IN cord-296075-8axbkyyz 52 19 vitro vitro FW cord-296075-8axbkyyz 52 20 after after IN cord-296075-8axbkyyz 52 21 differences difference NNS cord-296075-8axbkyyz 52 22 could could MD cord-296075-8axbkyyz 52 23 contribute contribute VB cord-296075-8axbkyyz 52 24 to to IN cord-296075-8axbkyyz 52 25 the the DT cord-296075-8axbkyyz 52 26 results result NNS cord-296075-8axbkyyz 52 27 shown show VBN cord-296075-8axbkyyz 52 28 in in IN cord-296075-8axbkyyz 52 29 Figs Figs NNPS cord-296075-8axbkyyz 52 30 . . . cord-296075-8axbkyyz 53 1 1 1 CD cord-296075-8axbkyyz 53 2 and and CC cord-296075-8axbkyyz 53 3 2 2 CD cord-296075-8axbkyyz 53 4 . . . cord-296075-8axbkyyz 54 1 If if IN cord-296075-8axbkyyz 54 2 in in IN cord-296075-8axbkyyz 54 3 vivo vivo NN cord-296075-8axbkyyz 54 4 priming prime VBG cord-296075-8axbkyyz 54 5 after after IN cord-296075-8axbkyyz 54 6 intraperitoneal intraperitoneal JJ cord-296075-8axbkyyz 54 7 inoculation inoculation NN cord-296075-8axbkyyz 54 8 endogenous endogenous JJ cord-296075-8axbkyyz 54 9 processing processing NN cord-296075-8axbkyyz 54 10 . . . cord-296075-8axbkyyz 55 1 To to TO cord-296075-8axbkyyz 55 2 determine determine VB cord-296075-8axbkyyz 55 3 if if IN cord-296075-8axbkyyz 55 4 this this DT cord-296075-8axbkyyz 55 5 in in IN cord-296075-8axbkyyz 55 6 fact fact NN cord-296075-8axbkyyz 55 7 occurred occur VBD cord-296075-8axbkyyz 55 8 , , , cord-296075-8axbkyyz 55 9 splenocytes splenocytes NNP cord-296075-8axbkyyz 55 10 from from IN cord-296075-8axbkyyz 55 11 intraperitoneally intraperitoneally RB cord-296075-8axbkyyz 55 12 infected infect VBN cord-296075-8axbkyyz 55 13 mice mouse NNS cord-296075-8axbkyyz 55 14 with with IN cord-296075-8axbkyyz 55 15 MHV MHV NNP cord-296075-8axbkyyz 55 16 - - HYPH cord-296075-8axbkyyz 55 17 JHM JHM NNP cord-296075-8axbkyyz 55 18 occurred occur VBD cord-296075-8axbkyyz 55 19 more more RBR cord-296075-8axbkyyz 55 20 efficiently efficiently RB cord-296075-8axbkyyz 55 21 with with IN cord-296075-8axbkyyz 55 22 the the DT cord-296075-8axbkyyz 55 23 H-2D H-2D NNP cord-296075-8axbkyyz 55 24 brestricted brestricte VBN cord-296075-8axbkyyz 55 25 epitope epitope NN cord-296075-8axbkyyz 55 26 , , , cord-296075-8axbkyyz 55 27 cells cell NNS cord-296075-8axbkyyz 55 28 responding respond VBG cord-296075-8axbkyyz 55 29 to to IN cord-296075-8axbkyyz 55 30 the the DT cord-296075-8axbkyyz 55 31 two two CD cord-296075-8axbkyyz 55 32 epitopes epitope NNS cord-296075-8axbkyyz 55 33 were be VBD cord-296075-8axbkyyz 55 34 stimulated stimulate VBN cord-296075-8axbkyyz 55 35 in in IN cord-296075-8axbkyyz 55 36 vitro vitro FW cord-296075-8axbkyyz 55 37 with with IN cord-296075-8axbkyyz 55 38 splenocytes splenocytes NNP cord-296075-8axbkyyz 55 39 coated coat VBN cord-296075-8axbkyyz 55 40 with with IN cord-296075-8axbkyyz 55 41 peptides peptide NNS cord-296075-8axbkyyz 55 42 corresponding correspond VBG cord-296075-8axbkyyz 55 43 to to IN cord-296075-8axbkyyz 56 1 the the DT cord-296075-8axbkyyz 56 2 H-2D H-2D NNP cord-296075-8axbkyyz 56 3 b b NN cord-296075-8axbkyyz 56 4 -and -and : cord-296075-8axbkyyz 56 5 H-2 h-2 NN cord-296075-8axbkyyz 56 6 K k NN cord-296075-8axbkyyz 56 7 b b NN cord-296075-8axbkyyz 56 8 -re -re : cord-296075-8axbkyyz 56 9 - - : cord-296075-8axbkyyz 56 10 should should MD cord-296075-8axbkyyz 56 11 be be VB cord-296075-8axbkyyz 56 12 present present JJ cord-296075-8axbkyyz 56 13 in in IN cord-296075-8axbkyyz 56 14 the the DT cord-296075-8axbkyyz 56 15 spleen spleen NNS cord-296075-8axbkyyz 56 16 at at IN cord-296075-8axbkyyz 56 17 different different JJ cord-296075-8axbkyyz 56 18 concentra concentra NNP cord-296075-8axbkyyz 56 19 - - : cord-296075-8axbkyyz 56 20 of of IN cord-296075-8axbkyyz 56 21 cultures culture NNS cord-296075-8axbkyyz 56 22 that that WDT cord-296075-8axbkyyz 56 23 contained contain VBD cord-296075-8axbkyyz 56 24 stimulators stimulator NNS cord-296075-8axbkyyz 56 25 alone alone RB cord-296075-8axbkyyz 56 26 without without IN cord-296075-8axbkyyz 56 27 responders responder NNS cord-296075-8axbkyyz 56 28 . . . cord-296075-8axbkyyz 57 1 These these DT cord-296075-8axbkyyz 57 2 assays assay NNS cord-296075-8axbkyyz 57 3 using use VBG cord-296075-8axbkyyz 57 4 peptide peptide NN cord-296075-8axbkyyz 57 5 - - HYPH cord-296075-8axbkyyz 57 6 coated coated JJ cord-296075-8axbkyyz 57 7 splenocytes splenocyte NNS cord-296075-8axbkyyz 57 8 as as IN cord-296075-8axbkyyz 57 9 stimulators stimulator NNS cord-296075-8axbkyyz 57 10 revealed reveal VBD cord-296075-8axbkyyz 57 11 comparable comparable JJ cord-296075-8axbkyyz 57 12 CTL CTL NNP cord-296075-8axbkyyz 57 13 precursor precursor NN cord-296075-8axbkyyz 57 14 / / SYM cord-296075-8axbkyyz 57 15 effector effector NN cord-296075-8axbkyyz 57 16 frequencies frequency NNS cord-296075-8axbkyyz 57 17 for for IN cord-296075-8axbkyyz 57 18 the the DT cord-296075-8axbkyyz 57 19 H-2 H-2 NNP cord-296075-8axbkyyz 57 20 K K NNP cord-296075-8axbkyyz 57 21 b b NNP cord-296075-8axbkyyz 57 22 -(average -(average CD cord-296075-8axbkyyz 57 23 1/1291 1/1291 CD cord-296075-8axbkyyz 57 24 , , , cord-296075-8axbkyyz 57 25 range range NNP cord-296075-8axbkyyz 57 26 1/927 1/927 CD cord-296075-8axbkyyz 57 27 - - HYPH cord-296075-8axbkyyz 57 28 1/1542 1/1542 CD cord-296075-8axbkyyz 57 29 spleen spleen NN cord-296075-8axbkyyz 57 30 cells cell NNS cord-296075-8axbkyyz 57 31 ) ) -RRB- cord-296075-8axbkyyz 57 32 and and CC cord-296075-8axbkyyz 57 33 H-2D H-2D NNP cord-296075-8axbkyyz 57 34 b b LS cord-296075-8axbkyyz 57 35 -restricted -restricted JJ cord-296075-8axbkyyz 57 36 ( ( -LRB- cord-296075-8axbkyyz 57 37 average average JJ cord-296075-8axbkyyz 57 38 1/987 1/987 CD cord-296075-8axbkyyz 57 39 , , , cord-296075-8axbkyyz 57 40 range range NNP cord-296075-8axbkyyz 57 41 1/380 1/380 CD cord-296075-8axbkyyz 57 42 - - HYPH cord-296075-8axbkyyz 57 43 1/1323 1/1323 NN cord-296075-8axbkyyz 57 44 spleen spleen NN cord-296075-8axbkyyz 57 45 cells cell NNS cord-296075-8axbkyyz 57 46 ) ) -RRB- cord-296075-8axbkyyz 57 47 epitopes epitope NNS cord-296075-8axbkyyz 57 48 in in IN cord-296075-8axbkyyz 57 49 these these DT cord-296075-8axbkyyz 57 50 mice mouse NNS cord-296075-8axbkyyz 57 51 . . . cord-296075-8axbkyyz 58 1 As as IN cord-296075-8axbkyyz 58 2 expected expect VBN cord-296075-8axbkyyz 58 3 , , , cord-296075-8axbkyyz 58 4 the the DT cord-296075-8axbkyyz 58 5 CTL CTL NNP cord-296075-8axbkyyz 58 6 precursor precursor NN cord-296075-8axbkyyz 58 7 / / SYM cord-296075-8axbkyyz 58 8 effector effector NN cord-296075-8axbkyyz 58 9 frequencies frequency NNS cord-296075-8axbkyyz 58 10 obtained obtain VBN cord-296075-8axbkyyz 58 11 from from IN cord-296075-8axbkyyz 58 12 infected infected JJ cord-296075-8axbkyyz 58 13 B6 b6 NN cord-296075-8axbkyyz 58 14 mice mouse NNS cord-296075-8axbkyyz 58 15 were be VBD cord-296075-8axbkyyz 58 16 significantly significantly RB cord-296075-8axbkyyz 58 17 higher high JJR cord-296075-8axbkyyz 58 18 than than IN cord-296075-8axbkyyz 58 19 those those DT cord-296075-8axbkyyz 58 20 obtained obtain VBN cord-296075-8axbkyyz 58 21 from from IN cord-296075-8axbkyyz 58 22 naive naive JJ cord-296075-8axbkyyz 58 23 B6 b6 NN cord-296075-8axbkyyz 58 24 mice mouse NNS cord-296075-8axbkyyz 58 25 ( ( -LRB- cord-296075-8axbkyyz 58 26 average average JJ cord-296075-8axbkyyz 58 27 1/171 1/171 CD cord-296075-8axbkyyz 58 28 , , , cord-296075-8axbkyyz 58 29 872 872 CD cord-296075-8axbkyyz 58 30 spleen spleen NN cord-296075-8axbkyyz 58 31 cells cell NNS cord-296075-8axbkyyz 58 32 and and CC cord-296075-8axbkyyz 58 33 1/660,803 1/660,803 CD cord-296075-8axbkyyz 58 34 spleen spleen NN cord-296075-8axbkyyz 58 35 cells cell NNS cord-296075-8axbkyyz 58 36 for for IN cord-296075-8axbkyyz 58 37 the the DT cord-296075-8axbkyyz 58 38 H-2 H-2 NNP cord-296075-8axbkyyz 58 39 K K NNP cord-296075-8axbkyyz 58 40 b b NNP cord-296075-8axbkyyz 58 41 -and -and : cord-296075-8axbkyyz 59 1 H-2D H-2D NNP cord-296075-8axbkyyz 59 2 b b LS cord-296075-8axbkyyz 60 1 -restricted -restricted JJ cord-296075-8axbkyyz 60 2 epitopes epitope NNS cord-296075-8axbkyyz 60 3 , , , cord-296075-8axbkyyz 60 4 respectively respectively RB cord-296075-8axbkyyz 60 5 ) ) -RRB- cord-296075-8axbkyyz 60 6 . . . cord-296075-8axbkyyz 61 1 Therefore therefore RB cord-296075-8axbkyyz 61 2 , , , cord-296075-8axbkyyz 61 3 in in IN cord-296075-8axbkyyz 61 4 vivo vivo FW cord-296075-8axbkyyz 61 5 priming priming NN cord-296075-8axbkyyz 61 6 was be VBD cord-296075-8axbkyyz 62 1 equally equally RB cord-296075-8axbkyyz 62 2 effec- effec- NN cord-296075-8axbkyyz 62 3 shown show VBN cord-296075-8axbkyyz 62 4 in in IN cord-296075-8axbkyyz 62 5 Fig Fig NNP cord-296075-8axbkyyz 62 6 . . . cord-296075-8axbkyyz 63 1 4 4 LS cord-296075-8axbkyyz 63 2 , , , cord-296075-8axbkyyz 63 3 similar similar JJ cord-296075-8axbkyyz 63 4 amounts amount NNS cord-296075-8axbkyyz 63 5 of of IN cord-296075-8axbkyyz 63 6 the the DT cord-296075-8axbkyyz 63 7 two two CD cord-296075-8axbkyyz 63 8 H-2 h-2 NN cord-296075-8axbkyyz 63 9 molecules molecule NNS cord-296075-8axbkyyz 63 10 were be VBD cord-296075-8axbkyyz 63 11 present present JJ cord-296075-8axbkyyz 63 12 on on IN cord-296075-8axbkyyz 63 13 EL-4-S35 el-4-s35 NN cord-296075-8axbkyyz 63 14 cells cell NNS cord-296075-8axbkyyz 63 15 , , , cord-296075-8axbkyyz 63 16 suggesting suggest VBG cord-296075-8axbkyyz 63 17 that that IN cord-296075-8axbkyyz 63 18 preferential preferential JJ cord-296075-8axbkyyz 63 19 down down JJ cord-296075-8axbkyyz 63 20 - - HYPH cord-296075-8axbkyyz 63 21 regulation regulation NN cord-296075-8axbkyyz 63 22 of of IN cord-296075-8axbkyyz 63 23 the the DT cord-296075-8axbkyyz 63 24 H-2 H-2 NNP cord-296075-8axbkyyz 63 25 K K NNP cord-296075-8axbkyyz 63 26 b b NN cord-296075-8axbkyyz 63 27 molecule molecule NN cord-296075-8axbkyyz 63 28 was be VBD cord-296075-8axbkyyz 63 29 not not RB cord-296075-8axbkyyz 63 30 the the DT cord-296075-8axbkyyz 63 31 tions tion NNS cord-296075-8axbkyyz 63 32 . . . cord-296075-8axbkyyz 64 1 On on IN cord-296075-8axbkyyz 64 2 the the DT cord-296075-8axbkyyz 64 3 other other JJ cord-296075-8axbkyyz 64 4 hand hand NN cord-296075-8axbkyyz 64 5 , , , cord-296075-8axbkyyz 64 6 if if IN cord-296075-8axbkyyz 64 7 inefficient inefficient JJ cord-296075-8axbkyyz 64 8 expansion expansion NN cord-296075-8axbkyyz 64 9 occurring occur VBG cord-296075-8axbkyyz 64 10 in in IN cord-296075-8axbkyyz 64 11 vitro vitro FW cord-296075-8axbkyyz 64 12 is be VBZ cord-296075-8axbkyyz 64 13 the the DT cord-296075-8axbkyyz 64 14 sole sole JJ cord-296075-8axbkyyz 64 15 explanation explanation NN cord-296075-8axbkyyz 64 16 for for IN cord-296075-8axbkyyz 64 17 the the DT cord-296075-8axbkyyz 64 18 different different JJ cord-296075-8axbkyyz 64 19 explanation explanation NN cord-296075-8axbkyyz 64 20 for for IN cord-296075-8axbkyyz 64 21 the the DT cord-296075-8axbkyyz 64 22 differences difference NNS cord-296075-8axbkyyz 64 23 in in IN cord-296075-8axbkyyz 64 24 recognition recognition NN cord-296075-8axbkyyz 64 25 between between IN cord-296075-8axbkyyz 64 26 the the DT cord-296075-8axbkyyz 64 27 H-2D H-2D NNP cord-296075-8axbkyyz 64 28 b b NN cord-296075-8axbkyyz 64 29 -and -and : cord-296075-8axbkyyz 64 30 H-2 h-2 NN cord-296075-8axbkyyz 64 31 K K NNP cord-296075-8axbkyyz 64 32 b b NN cord-296075-8axbkyyz 64 33 -restricted -restricted JJ cord-296075-8axbkyyz 64 34 epitopes epitope NNS cord-296075-8axbkyyz 64 35 . . . cord-296075-8axbkyyz 65 1 results result NNS cord-296075-8axbkyyz 65 2 presented present VBN cord-296075-8axbkyyz 65 3 above above RB cord-296075-8axbkyyz 65 4 , , , cord-296075-8axbkyyz 65 5 precursors precursor NNS cord-296075-8axbkyyz 65 6 to to IN cord-296075-8axbkyyz 65 7 the the DT cord-296075-8axbkyyz 65 8 two two CD cord-296075-8axbkyyz 65 9 epitopes epitope NNS cord-296075-8axbkyyz 65 10 should should MD cord-296075-8axbkyyz 65 11 be be VB cord-296075-8axbkyyz 65 12 present present JJ cord-296075-8axbkyyz 65 13 at at IN cord-296075-8axbkyyz 65 14 similar similar JJ cord-296075-8axbkyyz 65 15 concentrations concentration NNS cord-296075-8axbkyyz 65 16 in in IN cord-296075-8axbkyyz 65 17 the the DT cord-296075-8axbkyyz 65 18 spleen spleen NN cord-296075-8axbkyyz 65 19 . . . cord-296075-8axbkyyz 66 1 Three three CD cord-296075-8axbkyyz 66 2 independent independent JJ cord-296075-8axbkyyz 66 3 studies study NNS cord-296075-8axbkyyz 66 4 showed show VBD cord-296075-8axbkyyz 66 5 that that IN cord-296075-8axbkyyz 66 6 spleen spleen NN cord-296075-8axbkyyz 66 7 - - HYPH cord-296075-8axbkyyz 66 8 derived derive VBN cord-296075-8axbkyyz 66 9 CD8 CD8 NNP cord-296075-8axbkyyz 66 10 / / SYM cord-296075-8axbkyyz 66 11 cytotoxic cytotoxic JJ cord-296075-8axbkyyz 66 12 T t NN cord-296075-8axbkyyz 66 13 cells cell NNS cord-296075-8axbkyyz 66 14 from from IN cord-296075-8axbkyyz 66 15 intraperitoneally intraperitoneally RB cord-296075-8axbkyyz 66 16 in in IN cord-296075-8axbkyyz 66 17 - - HYPH cord-296075-8axbkyyz 66 18 To to TO cord-296075-8axbkyyz 66 19 compare compare VB cord-296075-8axbkyyz 66 20 the the DT cord-296075-8axbkyyz 66 21 CTL CTL NNP cord-296075-8axbkyyz 66 22 precursor precursor NN cord-296075-8axbkyyz 66 23 frequency frequency NN cord-296075-8axbkyyz 66 24 for for IN cord-296075-8axbkyyz 66 25 the the DT cord-296075-8axbkyyz 66 26 two two CD cord-296075-8axbkyyz 66 27 epitopes epitope NNS cord-296075-8axbkyyz 66 28 , , , cord-296075-8axbkyyz 66 29 limiting limit VBG cord-296075-8axbkyyz 66 30 dilution dilution NN cord-296075-8axbkyyz 66 31 analyses analysis NNS cord-296075-8axbkyyz 66 32 ( ( -LRB- cord-296075-8axbkyyz 66 33 LDA LDA NNP cord-296075-8axbkyyz 66 34 ) ) -RRB- cord-296075-8axbkyyz 66 35 using use VBG cord-296075-8axbkyyz 66 36 spleen spleen NN cord-296075-8axbkyyz 66 37 - - HYPH cord-296075-8axbkyyz 66 38 fected fecte VBN cord-296075-8axbkyyz 66 39 B6 b6 NN cord-296075-8axbkyyz 66 40 mice mouse NNS cord-296075-8axbkyyz 66 41 recognize recognize VBP cord-296075-8axbkyyz 66 42 the the DT cord-296075-8axbkyyz 66 43 H-2D H-2D NNP cord-296075-8axbkyyz 66 44 b b NN cord-296075-8axbkyyz 66 45 -but -but NFP cord-296075-8axbkyyz 66 46 not not RB cord-296075-8axbkyyz 66 47 the the DT cord-296075-8axbkyyz 66 48 H-2 H-2 NNP cord-296075-8axbkyyz 66 49 K K NNP cord-296075-8axbkyyz 66 50 brestricted brestricte VBN cord-296075-8axbkyyz 66 51 epitope epitope NN cord-296075-8axbkyyz 66 52 in in IN cord-296075-8axbkyyz 66 53 secondary secondary JJ cord-296075-8axbkyyz 66 54 CTL CTL NNP cord-296075-8axbkyyz 66 55 assays assay NNS cord-296075-8axbkyyz 66 56 . . . cord-296075-8axbkyyz 67 1 First first RB cord-296075-8axbkyyz 67 2 , , , cord-296075-8axbkyyz 67 3 Berg Berg NNP cord-296075-8axbkyyz 67 4 - - HYPH cord-296075-8axbkyyz 67 5 derived derive VBN cord-296075-8axbkyyz 67 6 lymphocytes lymphocyte NNS cord-296075-8axbkyyz 67 7 from from IN cord-296075-8axbkyyz 67 8 B6 b6 NN cord-296075-8axbkyyz 67 9 mice mouse NNS cord-296075-8axbkyyz 67 10 intraperitoneally intraperitoneally RB cord-296075-8axbkyyz 67 11 infected infect VBN cord-296075-8axbkyyz 67 12 with with IN cord-296075-8axbkyyz 67 13 MHV MHV NNP cord-296075-8axbkyyz 67 14 - - HYPH cord-296075-8axbkyyz 67 15 JHM JHM NNP cord-296075-8axbkyyz 67 16 8 8 CD cord-296075-8axbkyyz 67 17 days day NNS cord-296075-8axbkyyz 67 18 previously previously RB cord-296075-8axbkyyz 67 19 and and CC cord-296075-8axbkyyz 67 20 from from IN cord-296075-8axbkyyz 67 21 naive naive JJ cord-296075-8axbkyyz 67 22 B6 b6 NN cord-296075-8axbkyyz 67 23 mice mouse NNS cord-296075-8axbkyyz 67 24 were be VBD cord-296075-8axbkyyz 67 25 performed perform VBN cord-296075-8axbkyyz 67 26 ( ( -LRB- cord-296075-8axbkyyz 67 27 Fig Fig NNP cord-296075-8axbkyyz 67 28 . . . cord-296075-8axbkyyz 67 29 3 3 CD cord-296075-8axbkyyz 67 30 ) ) -RRB- cord-296075-8axbkyyz 67 31 . . . cord-296075-8axbkyyz 68 1 Both both DT cord-296075-8axbkyyz 68 2 virus virus NN cord-296075-8axbkyyz 68 3 - - HYPH cord-296075-8axbkyyz 68 4 specific specific JJ cord-296075-8axbkyyz 68 5 memory memory NN cord-296075-8axbkyyz 68 6 and and CC cord-296075-8axbkyyz 68 7 effector effector NN cord-296075-8axbkyyz 68 8 cells cell NNS cord-296075-8axbkyyz 68 9 should should MD cord-296075-8axbkyyz 68 10 be be VB cord-296075-8axbkyyz 68 11 present present JJ cord-296075-8axbkyyz 68 12 in in IN cord-296075-8axbkyyz 68 13 the the DT cord-296075-8axbkyyz 68 14 spleen spleen NNS cord-296075-8axbkyyz 68 15 at at IN cord-296075-8axbkyyz 68 16 this this DT cord-296075-8axbkyyz 68 17 time time NN cord-296075-8axbkyyz 68 18 ( ( -LRB- cord-296075-8axbkyyz 68 19 29 29 CD cord-296075-8axbkyyz 68 20 ) ) -RRB- cord-296075-8axbkyyz 68 21 , , , cord-296075-8axbkyyz 68 22 although although IN cord-296075-8axbkyyz 68 23 only only JJ cord-296075-8axbkyyz 68 24 memory memory NN cord-296075-8axbkyyz 68 25 cells cell NNS cord-296075-8axbkyyz 68 26 may may MD cord-296075-8axbkyyz 68 27 be be VB cord-296075-8axbkyyz 68 28 measured measure VBN cord-296075-8axbkyyz 68 29 in in IN cord-296075-8axbkyyz 68 30 this this DT cord-296075-8axbkyyz 68 31 secondary secondary JJ cord-296075-8axbkyyz 68 32 CTL CTL NNP cord-296075-8axbkyyz 68 33 assay assay NN cord-296075-8axbkyyz 68 34 ( ( -LRB- cord-296075-8axbkyyz 68 35 30 30 CD cord-296075-8axbkyyz 68 36 ) ) -RRB- cord-296075-8axbkyyz 68 37 . . . cord-296075-8axbkyyz 69 1 In in IN cord-296075-8axbkyyz 69 2 these these DT cord-296075-8axbkyyz 69 3 assays assay NNS cord-296075-8axbkyyz 69 4 , , , cord-296075-8axbkyyz 69 5 threefold threefold JJ cord-296075-8axbkyyz 69 6 serial serial JJ cord-296075-8axbkyyz 69 7 dilutions dilution NNS cord-296075-8axbkyyz 69 8 of of IN cord-296075-8axbkyyz 69 9 responder responder NN cord-296075-8axbkyyz 69 10 spleen spleen NN cord-296075-8axbkyyz 69 11 cells cell NNS cord-296075-8axbkyyz 69 12 from from IN cord-296075-8axbkyyz 69 13 individual individual JJ cord-296075-8axbkyyz 69 14 mice mouse NNS cord-296075-8axbkyyz 69 15 were be VBD cord-296075-8axbkyyz 69 16 plated plate VBN cord-296075-8axbkyyz 69 17 in in IN cord-296075-8axbkyyz 69 18 a a DT cord-296075-8axbkyyz 69 19 volume volume NN cord-296075-8axbkyyz 69 20 of of IN cord-296075-8axbkyyz 69 21 200 200 CD cord-296075-8axbkyyz 69 22 ml ml NNS cord-296075-8axbkyyz 69 23 in in IN cord-296075-8axbkyyz 69 24 the the DT cord-296075-8axbkyyz 69 25 wells well NNS cord-296075-8axbkyyz 69 26 of of IN cord-296075-8axbkyyz 69 27 96-well 96-well CD cord-296075-8axbkyyz 69 28 round round JJ cord-296075-8axbkyyz 69 29 bottom bottom JJ cord-296075-8axbkyyz 69 30 tissue tissue NN cord-296075-8axbkyyz 69 31 culture culture NN cord-296075-8axbkyyz 69 32 plates plate NNS cord-296075-8axbkyyz 69 33 ( ( -LRB- cord-296075-8axbkyyz 69 34 Costar Costar NNP cord-296075-8axbkyyz 69 35 , , , cord-296075-8axbkyyz 69 36 Cambridge Cambridge NNP cord-296075-8axbkyyz 69 37 , , , cord-296075-8axbkyyz 69 38 MA MA NNP cord-296075-8axbkyyz 69 39 ) ) -RRB- cord-296075-8axbkyyz 69 40 in in IN cord-296075-8axbkyyz 69 41 complete complete JJ cord-296075-8axbkyyz 69 42 RPMI RPMI NNP cord-296075-8axbkyyz 69 43 media medium NNS cord-296075-8axbkyyz 69 44 supplemented supplement VBN cord-296075-8axbkyyz 69 45 with with IN cord-296075-8axbkyyz 69 46 5 5 CD cord-296075-8axbkyyz 69 47 % % NN cord-296075-8axbkyyz 69 48 rat rat NN cord-296075-8axbkyyz 69 49 concanavalin concanavalin NNP cord-296075-8axbkyyz 69 50 A a DT cord-296075-8axbkyyz 69 51 supernatant supernatant NN cord-296075-8axbkyyz 69 52 containing contain VBG cord-296075-8axbkyyz 69 53 50 50 CD cord-296075-8axbkyyz 69 54 mM mm CD cord-296075-8axbkyyz 69 55 methyl methyl NN cord-296075-8axbkyyz 69 56 - - HYPH cord-296075-8axbkyyz 69 57 a a DT cord-296075-8axbkyyz 69 58 - - HYPH cord-296075-8axbkyyz 69 59 D d NN cord-296075-8axbkyyz 69 60 - - HYPH cord-296075-8axbkyyz 69 61 mannopyranoside mannopyranoside NN cord-296075-8axbkyyz 69 62 . . . cord-296075-8axbkyyz 70 1 In in IN cord-296075-8axbkyyz 70 2 addition addition NN cord-296075-8axbkyyz 70 3 to to IN cord-296075-8axbkyyz 70 4 immune immune JJ cord-296075-8axbkyyz 70 5 or or CC cord-296075-8axbkyyz 70 6 naive naive JJ cord-296075-8axbkyyz 70 7 responder responder NN cord-296075-8axbkyyz 70 8 splenocytes splenocytes NN cord-296075-8axbkyyz 70 9 , , , cord-296075-8axbkyyz 70 10 individual individual JJ cord-296075-8axbkyyz 70 11 wells well NNS cord-296075-8axbkyyz 70 12 received receive VBD cord-296075-8axbkyyz 70 13 5 5 CD cord-296075-8axbkyyz 70 14 1 1 CD cord-296075-8axbkyyz 70 15 10 10 CD cord-296075-8axbkyyz 70 16 5 5 CD cord-296075-8axbkyyz 70 17 irradiated irradiate VBN cord-296075-8axbkyyz 70 18 ( ( -LRB- cord-296075-8axbkyyz 70 19 3000 3000 CD cord-296075-8axbkyyz 70 20 rad rad NNP cord-296075-8axbkyyz 70 21 ) ) -RRB- cord-296075-8axbkyyz 70 22 syngeneic syngeneic NNS cord-296075-8axbkyyz 70 23 spleen spleen NN cord-296075-8axbkyyz 70 24 cells cell NNS cord-296075-8axbkyyz 70 25 which which WDT cord-296075-8axbkyyz 70 26 had have VBD cord-296075-8axbkyyz 70 27 been be VBN cord-296075-8axbkyyz 70 28 coated coat VBN cord-296075-8axbkyyz 70 29 with with IN cord-296075-8axbkyyz 70 30 peptide peptide NN cord-296075-8axbkyyz 70 31 ( ( -LRB- cord-296075-8axbkyyz 70 32 10 10 CD cord-296075-8axbkyyz 70 33 was be VBD cord-296075-8axbkyyz 70 34 greater great JJR cord-296075-8axbkyyz 70 35 than than IN cord-296075-8axbkyyz 70 36 3 3 CD cord-296075-8axbkyyz 70 37 standard standard JJ cord-296075-8axbkyyz 70 38 deviations deviation NNS cord-296075-8axbkyyz 70 39 above above IN cord-296075-8axbkyyz 70 40 the the DT cord-296075-8axbkyyz 70 41 mean mean NN cord-296075-8axbkyyz 70 42 suggested suggest VBD cord-296075-8axbkyyz 70 43 that that IN cord-296075-8axbkyyz 70 44 in in IN cord-296075-8axbkyyz 70 45 vivo vivo NN cord-296075-8axbkyyz 70 46 priming prime VBG cord-296075-8axbkyyz 70 47 in in IN cord-296075-8axbkyyz 70 48 the the DT cord-296075-8axbkyyz 70 49 spleen spleen NN cord-296075-8axbkyyz 70 50 was be VBD cord-296075-8axbkyyz 70 51 similarly similarly RB cord-296075-8axbkyyz 70 52 efficient efficient JJ cord-296075-8axbkyyz 70 53 for for IN cord-296075-8axbkyyz 70 54 both both DT cord-296075-8axbkyyz 70 55 epitopes epitope NNS cord-296075-8axbkyyz 70 56 . . . cord-296075-8axbkyyz 71 1 These these DT cord-296075-8axbkyyz 71 2 data datum NNS cord-296075-8axbkyyz 71 3 are be VBP cord-296075-8axbkyyz 71 4 most most RBS cord-296075-8axbkyyz 71 5 consistent consistent JJ cord-296075-8axbkyyz 71 6 with with IN cord-296075-8axbkyyz 71 7 inefficient inefficient JJ cord-296075-8axbkyyz 71 8 in in IN cord-296075-8axbkyyz 71 9 vitro vitro FW cord-296075-8axbkyyz 71 10 stimulation stimulation NN cord-296075-8axbkyyz 71 11 of of IN cord-296075-8axbkyyz 71 12 the the DT cord-296075-8axbkyyz 71 13 H-2 H-2 NNP cord-296075-8axbkyyz 71 14 K K NNP cord-296075-8axbkyyz 71 15 b b NNP cord-296075-8axbkyyz 71 16 -restricted -restricted JJ cord-296075-8axbkyyz 71 17 CD8 CD8 NNP cord-296075-8axbkyyz 71 18 / / SYM cord-296075-8axbkyyz 71 19 T T NNP cord-296075-8axbkyyz 71 20 cells cell NNS cord-296075-8axbkyyz 71 21 . . . cord-296075-8axbkyyz 72 1 Antigen Antigen NNP cord-296075-8axbkyyz 72 2 is be VBZ cord-296075-8axbkyyz 72 3 likely likely JJ cord-296075-8axbkyyz 72 4 to to TO cord-296075-8axbkyyz 72 5 be be VB cord-296075-8axbkyyz 72 6 processed process VBN cord-296075-8axbkyyz 72 7 by by IN cord-296075-8axbkyyz 72 8 different different JJ cord-296075-8axbkyyz 72 9 antigen antigen NN cord-296075-8axbkyyz 72 10 presenting present VBG cord-296075-8axbkyyz 72 11 cells cell NNS cord-296075-8axbkyyz 72 12 ( ( -LRB- cord-296075-8axbkyyz 72 13 APCs apc NNS cord-296075-8axbkyyz 72 14 ) ) -RRB- cord-296075-8axbkyyz 72 15 in in IN cord-296075-8axbkyyz 72 16 vivo vivo NN cord-296075-8axbkyyz 72 17 and and CC cord-296075-8axbkyyz 72 18 in in IN cord-296075-8axbkyyz 72 19 vitro vitro FW cord-296075-8axbkyyz 72 20 and and CC cord-296075-8axbkyyz 72 21 at at IN cord-296075-8axbkyyz 72 22 different different JJ cord-296075-8axbkyyz 72 23 sites site NNS cord-296075-8axbkyyz 72 24 in in IN cord-296075-8axbkyyz 72 25 vivo vivo NN cord-296075-8axbkyyz 72 26 . . . cord-296075-8axbkyyz 73 1 The the DT cord-296075-8axbkyyz 73 2 microenvironment microenvironment NN cord-296075-8axbkyyz 73 3 may may MD cord-296075-8axbkyyz 73 4 allow allow VB cord-296075-8axbkyyz 73 5 adequate adequate JJ cord-296075-8axbkyyz 73 6 presentation presentation NN cord-296075-8axbkyyz 73 7 of of IN cord-296075-8axbkyyz 73 8 the the DT cord-296075-8axbkyyz 73 9 H-2 H-2 NNP cord-296075-8axbkyyz 73 10 K K NNP cord-296075-8axbkyyz 73 11 b b NN cord-296075-8axbkyyz 73 12 -restricted -restricted JJ cord-296075-8axbkyyz 73 13 epitope epitope NN cord-296075-8axbkyyz 73 14 in in IN cord-296075-8axbkyyz 73 15 vivo vivo NN cord-296075-8axbkyyz 73 16 but but CC cord-296075-8axbkyyz 73 17 this this DT cord-296075-8axbkyyz 73 18 may may MD cord-296075-8axbkyyz 73 19 not not RB cord-296075-8axbkyyz 73 20 occur occur VB cord-296075-8axbkyyz 73 21 in in IN cord-296075-8axbkyyz 73 22 vitro vitro FW cord-296075-8axbkyyz 73 23 . . . cord-296075-8axbkyyz 74 1 Although although IN cord-296075-8axbkyyz 74 2 some some DT cord-296075-8axbkyyz 74 3 H-2 h-2 NN cord-296075-8axbkyyz 74 4 K K NNP cord-296075-8axbkyyz 74 5 b b NN cord-296075-8axbkyyz 74 6 -restricted -restricted JJ cord-296075-8axbkyyz 74 7 epitope epitope NN cord-296075-8axbkyyz 74 8 is be VBZ cord-296075-8axbkyyz 74 9 likely likely RB cord-296075-8axbkyyz 74 10 expressed express VBN cord-296075-8axbkyyz 74 11 on on IN cord-296075-8axbkyyz 74 12 the the DT cord-296075-8axbkyyz 74 13 cell cell NN cord-296075-8axbkyyz 74 14 surface surface NN cord-296075-8axbkyyz 74 15 of of IN cord-296075-8axbkyyz 74 16 APCs apc NNS cord-296075-8axbkyyz 74 17 in in IN cord-296075-8axbkyyz 74 18 vitro vitro FW cord-296075-8axbkyyz 74 19 , , , cord-296075-8axbkyyz 74 20 this this DT cord-296075-8axbkyyz 74 21 amount amount NN cord-296075-8axbkyyz 74 22 may may MD cord-296075-8axbkyyz 74 23 be be VB cord-296075-8axbkyyz 74 24 inadequate inadequate JJ cord-296075-8axbkyyz 74 25 to to TO cord-296075-8axbkyyz 74 26 stimulate stimulate VB cord-296075-8axbkyyz 74 27 in in IN cord-296075-8axbkyyz 74 28 vivo vivo NN cord-296075-8axbkyyz 74 29 primed prime VBN cord-296075-8axbkyyz 74 30 cells cell NNS cord-296075-8axbkyyz 74 31 , , , cord-296075-8axbkyyz 74 32 in in IN cord-296075-8axbkyyz 74 33 fected fecte VBN cord-296075-8axbkyyz 74 34 syngeneic syngeneic NNS cord-296075-8axbkyyz 74 35 spleen spleen NN cord-296075-8axbkyyz 74 36 cells cell NNS cord-296075-8axbkyyz 74 37 , , , cord-296075-8axbkyyz 74 38 a a DT cord-296075-8axbkyyz 74 39 step step NN cord-296075-8axbkyyz 74 40 which which WDT cord-296075-8axbkyyz 74 41 our -PRON- PRP$ cord-296075-8axbkyyz 74 42 study study NN cord-296075-8axbkyyz 74 43 24 24 CD cord-296075-8axbkyyz 74 44 , , , cord-296075-8axbkyyz 74 45 76 76 CD cord-296075-8axbkyyz 74 46 - - SYM cord-296075-8axbkyyz 74 47 85 85 CD cord-296075-8axbkyyz 74 48 ( ( -LRB- cord-296075-8axbkyyz 74 49 1973 1973 CD cord-296075-8axbkyyz 74 50 ) ) -RRB- cord-296075-8axbkyyz 74 51 . . . cord-296075-8axbkyyz 75 1 indicates indicate VBZ cord-296075-8axbkyyz 75 2 inadequately inadequately RB cord-296075-8axbkyyz 75 3 stimulates stimulate VBZ cord-296075-8axbkyyz 75 4 the the DT cord-296075-8axbkyyz 75 5 H-2 h-2 NN cord-296075-8axbkyyz 75 6 K K NNP cord-296075-8axbkyyz 75 7 b b NNP cord-296075-8axbkyyz 75 8 -restricted -restricted JJ cord-296075-8axbkyyz 75 9 5 5 CD cord-296075-8axbkyyz 75 10 . . . cord-296075-8axbkyyz 76 1 Nagashima Nagashima NNP cord-296075-8axbkyyz 76 2 , , , cord-296075-8axbkyyz 76 3 K. K. NNP cord-296075-8axbkyyz 76 4 , , , cord-296075-8axbkyyz 76 5 Wege Wege NNP cord-296075-8axbkyyz 76 6 , , , cord-296075-8axbkyyz 76 7 H. H. NNP cord-296075-8axbkyyz 76 8 , , , cord-296075-8axbkyyz 76 9 Meyermann Meyermann NNP cord-296075-8axbkyyz 76 10 , , , cord-296075-8axbkyyz 76 11 R. R. NNP cord-296075-8axbkyyz 76 12 , , , cord-296075-8axbkyyz 76 13 and and CC cord-296075-8axbkyyz 76 14 ter ter NNP cord-296075-8axbkyyz 76 15 Meulen Meulen NNP cord-296075-8axbkyyz 76 16 , , , cord-296075-8axbkyyz 76 17 V. V. NNP cord-296075-8axbkyyz 76 18 , , , cord-296075-8axbkyyz 76 19 Acta Acta NNP cord-296075-8axbkyyz 76 20 precursors precursor NNS cord-296075-8axbkyyz 76 21 , , , cord-296075-8axbkyyz 76 22 leading lead VBG cord-296075-8axbkyyz 76 23 to to IN cord-296075-8axbkyyz 76 24 a a DT cord-296075-8axbkyyz 76 25 skewed skewed JJ cord-296075-8axbkyyz 76 26 result result NN cord-296075-8axbkyyz 76 27 . . . cord-296075-8axbkyyz 77 1 Third third RB cord-296075-8axbkyyz 77 2 , , , cord-296075-8axbkyyz 77 3 the the DT cord-296075-8axbkyyz 77 4 data datum NNS cord-296075-8axbkyyz 77 5 H-2D H-2D NNP cord-296075-8axbkyyz 77 6 b b NNP cord-296075-8axbkyyz 77 7 -restricted -restricted JJ cord-296075-8axbkyyz 77 8 epitope epitope NN cord-296075-8axbkyyz 77 9 in in IN cord-296075-8axbkyyz 77 10 cytotoxicity cytotoxicity NN cord-296075-8axbkyyz 77 11 assays assay NNS cord-296075-8axbkyyz 77 12 . . . cord-296075-8axbkyyz 78 1 9 9 LS cord-296075-8axbkyyz 78 2 . . . cord-296075-8axbkyyz 79 1 Yamaguchi Yamaguchi NNP cord-296075-8axbkyyz 79 2 , , , cord-296075-8axbkyyz 79 3 K. K. NNP cord-296075-8axbkyyz 79 4 , , , cord-296075-8axbkyyz 79 5 Goto Goto NNP cord-296075-8axbkyyz 79 6 , , , cord-296075-8axbkyyz 79 7 N. N. NNP cord-296075-8axbkyyz 79 8 , , , cord-296075-8axbkyyz 79 9 Kyuwa Kyuwa NNP cord-296075-8axbkyyz 79 10 , , , cord-296075-8axbkyyz 79 11 S. S. NNP cord-296075-8axbkyyz 79 12 , , , cord-296075-8axbkyyz 79 13 Hayami Hayami NNP cord-296075-8axbkyyz 79 14 , , , cord-296075-8axbkyyz 79 15 M. M. NNP cord-296075-8axbkyyz 79 16 , , , cord-296075-8axbkyyz 79 17 and and CC cord-296075-8axbkyyz 79 18 Toyoda Toyoda NNP cord-296075-8axbkyyz 79 19 , , , cord-296075-8axbkyyz 79 20 Y. Y. NNP cord-296075-8axbkyyz 79 21 , , , cord-296075-8axbkyyz 79 22 J. J. NNP cord-296075-8axbkyyz 79 23 Neuroimmunol Neuroimmunol NNP cord-296075-8axbkyyz 79 24 . . . cord-296075-8axbkyyz 80 1 32 32 CD cord-296075-8axbkyyz 80 2 , , , cord-296075-8axbkyyz 80 3 1 1 CD cord-296075-8axbkyyz 80 4 - - SYM cord-296075-8axbkyyz 80 5 9 9 CD cord-296075-8axbkyyz 80 6 ( ( -LRB- cord-296075-8axbkyyz 80 7 1991 1991 CD cord-296075-8axbkyyz 80 8 ) ) -RRB- cord-296075-8axbkyyz 80 9 . . . cord-296075-8axbkyyz 81 1 In in IN cord-296075-8axbkyyz 81 2 contrast contrast NN cord-296075-8axbkyyz 81 3 to to IN cord-296075-8axbkyyz 81 4 these these DT cord-296075-8axbkyyz 81 5 data datum NNS cord-296075-8axbkyyz 81 6 , , , cord-296075-8axbkyyz 81 7 use use NN cord-296075-8axbkyyz 81 8 of of IN cord-296075-8axbkyyz 81 9 peptide peptide NN cord-296075-8axbkyyz 81 10 - - HYPH cord-296075-8axbkyyz 81 11 coated coated JJ cord-296075-8axbkyyz 81 12 sple- sple- NN cord-296075-8axbkyyz 81 13 frequencies frequency NNS cord-296075-8axbkyyz 81 14 were be VBD cord-296075-8axbkyyz 81 15 measured measure VBN cord-296075-8axbkyyz 81 16 for for IN cord-296075-8axbkyyz 81 17 the the DT cord-296075-8axbkyyz 81 18 two two CD cord-296075-8axbkyyz 81 19 epitopes epitope NNS cord-296075-8axbkyyz 81 20 and and CC cord-296075-8axbkyyz 81 21 Proc proc NN cord-296075-8axbkyyz 81 22 . . . cord-296075-8axbkyyz 82 1 Natl Natl NNP cord-296075-8axbkyyz 82 2 . . . cord-296075-8axbkyyz 83 1 Acad Acad NNP cord-296075-8axbkyyz 83 2 . . . cord-296075-8axbkyyz 84 1 Sci Sci NNP cord-296075-8axbkyyz 84 2 . . NNP cord-296075-8axbkyyz 84 3 USA USA NNP