id	sid	tid	token	lemma	pos
cord-301755-fxfsr9bj	1	1	key	key	NN
cord-301755-fxfsr9bj	1	2	:	:	:
cord-301755-fxfsr9bj	1	3	cord-301755-fxfsr9bj	cord-301755-fxfsr9bj	NNP
cord-301755-fxfsr9bj	1	4	authors	author	NNS
cord-301755-fxfsr9bj	1	5	:	:	:
cord-301755-fxfsr9bj	1	6	Wang	Wang	NNP
cord-301755-fxfsr9bj	1	7	,	,	,
cord-301755-fxfsr9bj	1	8	F.-I.	F.-I.	NNP
cord-301755-fxfsr9bj	1	9	;	;	:
cord-301755-fxfsr9bj	1	10	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	1	11	,	,	,
cord-301755-fxfsr9bj	1	12	John	John	NNP
cord-301755-fxfsr9bj	1	13	O.	O.	NNP
cord-301755-fxfsr9bj	1	14	;	;	:
cord-301755-fxfsr9bj	1	15	Lai	Lai	NNP
cord-301755-fxfsr9bj	1	16	,	,	,
cord-301755-fxfsr9bj	1	17	Michael	Michael	NNP
cord-301755-fxfsr9bj	1	18	M.C.	M.C.	NNP
cord-301755-fxfsr9bj	1	19	title	title	NN
cord-301755-fxfsr9bj	1	20	:	:	:
cord-301755-fxfsr9bj	2	1	Sequence	sequence	NN
cord-301755-fxfsr9bj	2	2	analysis	analysis	NN
cord-301755-fxfsr9bj	2	3	of	of	IN
cord-301755-fxfsr9bj	2	4	the	the	DT
cord-301755-fxfsr9bj	2	5	spike	spike	NN
cord-301755-fxfsr9bj	2	6	protein	protein	NN
cord-301755-fxfsr9bj	2	7	gene	gene	NN
cord-301755-fxfsr9bj	2	8	of	of	IN
cord-301755-fxfsr9bj	2	9	murine	murine	JJ
cord-301755-fxfsr9bj	2	10	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	2	11	variants	variant	NNS
cord-301755-fxfsr9bj	2	12	:	:	:
cord-301755-fxfsr9bj	2	13	Study	study	NN
cord-301755-fxfsr9bj	2	14	of	of	IN
cord-301755-fxfsr9bj	2	15	genetic	genetic	JJ
cord-301755-fxfsr9bj	2	16	sites	site	NNS
cord-301755-fxfsr9bj	2	17	affecting	affect	VBG
cord-301755-fxfsr9bj	2	18	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	2	19	date	date	NN
cord-301755-fxfsr9bj	2	20	:	:	:
cord-301755-fxfsr9bj	2	21	1992	1992	CD
cord-301755-fxfsr9bj	2	22	-	-	HYPH
cord-301755-fxfsr9bj	2	23	02	02	CD
cord-301755-fxfsr9bj	2	24	-	-	HYPH
cord-301755-fxfsr9bj	2	25	29	29	CD
cord-301755-fxfsr9bj	2	26	journal	journal	NN
cord-301755-fxfsr9bj	2	27	:	:	:
cord-301755-fxfsr9bj	3	1	Virology	virology	NN
cord-301755-fxfsr9bj	3	2	DOI	DOI	NNP
cord-301755-fxfsr9bj	3	3	:	:	:
cord-301755-fxfsr9bj	3	4	10.1016/0042	10.1016/0042	CD
cord-301755-fxfsr9bj	3	5	-	-	HYPH
cord-301755-fxfsr9bj	3	6	6822(92)90041-m	6822(92)90041-m	CD
cord-301755-fxfsr9bj	3	7	sha	sha	NNP
cord-301755-fxfsr9bj	3	8	:	:	:
cord-301755-fxfsr9bj	4	1	8e3516329587d358addc1db03585110e303971dc	8e3516329587d358addc1db03585110e303971dc	CD
cord-301755-fxfsr9bj	4	2	doc_id	doc_id	CD
cord-301755-fxfsr9bj	4	3	:	:	:
cord-301755-fxfsr9bj	5	1	301755	301755	CD
cord-301755-fxfsr9bj	5	2	cord_uid	cord_uid	NNS
cord-301755-fxfsr9bj	5	3	:	:	:
cord-301755-fxfsr9bj	6	1	fxfsr9bj	fxfsr9bj	NNP
cord-301755-fxfsr9bj	6	2	Abstract	Abstract	NNP
cord-301755-fxfsr9bj	6	3	Mouse	Mouse	NNP
cord-301755-fxfsr9bj	6	4	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	6	5	virus	virus	NN
cord-301755-fxfsr9bj	6	6	(	(	-LRB-
cord-301755-fxfsr9bj	6	7	MHV	MHV	NNP
cord-301755-fxfsr9bj	6	8	)	)	-RRB-
cord-301755-fxfsr9bj	6	9	,	,	,
cord-301755-fxfsr9bj	6	10	a	a	DT
cord-301755-fxfsr9bj	6	11	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	6	12	,	,	,
cord-301755-fxfsr9bj	6	13	causes	cause	VBZ
cord-301755-fxfsr9bj	6	14	encephalitis	encephalitis	NN
cord-301755-fxfsr9bj	6	15	and	and	CC
cord-301755-fxfsr9bj	6	16	demyelination	demyelination	NN
cord-301755-fxfsr9bj	6	17	in	in	IN
cord-301755-fxfsr9bj	6	18	susceptible	susceptible	JJ
cord-301755-fxfsr9bj	6	19	rodents	rodent	NNS
cord-301755-fxfsr9bj	6	20	.	.	.
cord-301755-fxfsr9bj	7	1	Previous	previous	JJ
cord-301755-fxfsr9bj	7	2	investigations	investigation	NNS
cord-301755-fxfsr9bj	7	3	have	have	VBP
cord-301755-fxfsr9bj	7	4	shown	show	VBN
cord-301755-fxfsr9bj	7	5	that	that	IN
cord-301755-fxfsr9bj	7	6	the	the	DT
cord-301755-fxfsr9bj	7	7	MHV	MHV	NNP
cord-301755-fxfsr9bj	7	8	spike	spike	NN
cord-301755-fxfsr9bj	7	9	(	(	-LRB-
cord-301755-fxfsr9bj	7	10	S	s	NN
cord-301755-fxfsr9bj	7	11	)	)	-RRB-
cord-301755-fxfsr9bj	7	12	protein	protein	NN
cord-301755-fxfsr9bj	7	13	is	be	VBZ
cord-301755-fxfsr9bj	7	14	a	a	DT
cord-301755-fxfsr9bj	7	15	critical	critical	JJ
cord-301755-fxfsr9bj	7	16	determinant	determinant	NN
cord-301755-fxfsr9bj	7	17	of	of	IN
cord-301755-fxfsr9bj	7	18	viral	viral	JJ
cord-301755-fxfsr9bj	7	19	tropism	tropism	NN
cord-301755-fxfsr9bj	7	20	and	and	CC
cord-301755-fxfsr9bj	7	21	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	7	22	in	in	IN
cord-301755-fxfsr9bj	7	23	mice	mouse	NNS
cord-301755-fxfsr9bj	7	24	and	and	CC
cord-301755-fxfsr9bj	7	25	rats	rat	NNS
cord-301755-fxfsr9bj	7	26	.	.	.
cord-301755-fxfsr9bj	8	1	To	to	TO
cord-301755-fxfsr9bj	8	2	understand	understand	VB
cord-301755-fxfsr9bj	8	3	the	the	DT
cord-301755-fxfsr9bj	8	4	molecular	molecular	JJ
cord-301755-fxfsr9bj	8	5	basis	basis	NN
cord-301755-fxfsr9bj	8	6	of	of	IN
cord-301755-fxfsr9bj	8	7	MHV	MHV	NNP
cord-301755-fxfsr9bj	8	8	neuropathogenesis	neuropathogenesis	NN
cord-301755-fxfsr9bj	8	9	,	,	,
cord-301755-fxfsr9bj	8	10	we	-PRON-	PRP
cord-301755-fxfsr9bj	8	11	studied	study	VBD
cord-301755-fxfsr9bj	8	12	the	the	DT
cord-301755-fxfsr9bj	8	13	spike	spike	NN
cord-301755-fxfsr9bj	8	14	protein	protein	NN
cord-301755-fxfsr9bj	8	15	gene	gene	NN
cord-301755-fxfsr9bj	8	16	sequences	sequence	NNS
cord-301755-fxfsr9bj	8	17	of	of	IN
cord-301755-fxfsr9bj	8	18	several	several	JJ
cord-301755-fxfsr9bj	8	19	neutralization	neutralization	NN
cord-301755-fxfsr9bj	8	20	-	-	HYPH
cord-301755-fxfsr9bj	8	21	resistant	resistant	JJ
cord-301755-fxfsr9bj	8	22	variants	variant	NNS
cord-301755-fxfsr9bj	8	23	of	of	IN
cord-301755-fxfsr9bj	8	24	the	the	DT
cord-301755-fxfsr9bj	8	25	JHM	JHM	NNP
cord-301755-fxfsr9bj	8	26	strain	strain	NN
cord-301755-fxfsr9bj	8	27	of	of	IN
cord-301755-fxfsr9bj	8	28	MHV	MHV	NNP
cord-301755-fxfsr9bj	8	29	,	,	,
cord-301755-fxfsr9bj	8	30	which	which	WDT
cord-301755-fxfsr9bj	8	31	were	be	VBD
cord-301755-fxfsr9bj	8	32	selected	select	VBN
cord-301755-fxfsr9bj	8	33	with	with	IN
cord-301755-fxfsr9bj	8	34	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	8	35	antibodies	antibody	NNS
cord-301755-fxfsr9bj	8	36	(	(	-LRB-
cord-301755-fxfsr9bj	8	37	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	8	38	)	)	-RRB-
cord-301755-fxfsr9bj	8	39	specific	specific	JJ
cord-301755-fxfsr9bj	8	40	for	for	IN
cord-301755-fxfsr9bj	8	41	the	the	DT
cord-301755-fxfsr9bj	8	42	S	S	NNP
cord-301755-fxfsr9bj	8	43	protein	protein	NN
cord-301755-fxfsr9bj	8	44	.	.	.
cord-301755-fxfsr9bj	9	1	We	-PRON-	PRP
cord-301755-fxfsr9bj	9	2	found	find	VBD
cord-301755-fxfsr9bj	9	3	that	that	IN
cord-301755-fxfsr9bj	9	4	variant	variant	NN
cord-301755-fxfsr9bj	9	5	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	9	6	,	,	,
cord-301755-fxfsr9bj	9	7	which	which	WDT
cord-301755-fxfsr9bj	9	8	was	be	VBD
cord-301755-fxfsr9bj	9	9	selected	select	VBN
cord-301755-fxfsr9bj	9	10	with	with	IN
cord-301755-fxfsr9bj	9	11	MAb	MAb	NNPS
cord-301755-fxfsr9bj	9	12	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	9	13	and	and	CC
cord-301755-fxfsr9bj	9	14	primarily	primarily	RB
cord-301755-fxfsr9bj	9	15	caused	cause	VBD
cord-301755-fxfsr9bj	9	16	demyelination	demyelination	NN
cord-301755-fxfsr9bj	9	17	,	,	,
cord-301755-fxfsr9bj	9	18	had	have	VBD
cord-301755-fxfsr9bj	9	19	a	a	DT
cord-301755-fxfsr9bj	9	20	single	single	JJ
cord-301755-fxfsr9bj	9	21	point	point	NN
cord-301755-fxfsr9bj	9	22	mutation	mutation	NN
cord-301755-fxfsr9bj	9	23	at	at	IN
cord-301755-fxfsr9bj	9	24	nucleotide	nucleotide	NN
cord-301755-fxfsr9bj	9	25	(	(	-LRB-
cord-301755-fxfsr9bj	9	26	NT	NT	NNP
cord-301755-fxfsr9bj	9	27	)	)	-RRB-
cord-301755-fxfsr9bj	9	28	3340	3340	CD
cord-301755-fxfsr9bj	9	29	,	,	,
cord-301755-fxfsr9bj	9	30	as	as	IN
cord-301755-fxfsr9bj	9	31	compared	compare	VBN
cord-301755-fxfsr9bj	9	32	to	to	IN
cord-301755-fxfsr9bj	9	33	the	the	DT
cord-301755-fxfsr9bj	9	34	parental	parental	JJ
cord-301755-fxfsr9bj	9	35	JHM	JHM	NNP
cord-301755-fxfsr9bj	9	36	virus	virus	NN
cord-301755-fxfsr9bj	9	37	,	,	,
cord-301755-fxfsr9bj	9	38	which	which	WDT
cord-301755-fxfsr9bj	9	39	predominantly	predominantly	RB
cord-301755-fxfsr9bj	9	40	caused	cause	VBD
cord-301755-fxfsr9bj	9	41	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	9	42	.	.	.
cord-301755-fxfsr9bj	10	1	This	this	DT
cord-301755-fxfsr9bj	10	2	site	site	NN
cord-301755-fxfsr9bj	10	3	was	be	VBD
cord-301755-fxfsr9bj	10	4	in	in	IN
cord-301755-fxfsr9bj	10	5	the	the	DT
cord-301755-fxfsr9bj	10	6	S2	S2	NNP
cord-301755-fxfsr9bj	10	7	subunit	subunit	NN
cord-301755-fxfsr9bj	10	8	of	of	IN
cord-301755-fxfsr9bj	10	9	the	the	DT
cord-301755-fxfsr9bj	10	10	S	S	NNP
cord-301755-fxfsr9bj	10	11	protein	protein	NN
cord-301755-fxfsr9bj	10	12	.	.	.
cord-301755-fxfsr9bj	11	1	In	in	IN
cord-301755-fxfsr9bj	11	2	contrast	contrast	NN
cord-301755-fxfsr9bj	11	3	,	,	,
cord-301755-fxfsr9bj	11	4	variant	variant	NN
cord-301755-fxfsr9bj	11	5	7.2-V-1	7.2-v-1	CD
cord-301755-fxfsr9bj	11	6	,	,	,
cord-301755-fxfsr9bj	11	7	which	which	WDT
cord-301755-fxfsr9bj	11	8	was	be	VBD
cord-301755-fxfsr9bj	11	9	selected	select	VBN
cord-301755-fxfsr9bj	11	10	with	with	IN
cord-301755-fxfsr9bj	11	11	MAb	MAb	NNS
cord-301755-fxfsr9bj	11	12	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	11	13	and	and	CC
cord-301755-fxfsr9bj	11	14	primarily	primarily	RB
cord-301755-fxfsr9bj	11	15	caused	cause	VBD
cord-301755-fxfsr9bj	11	16	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	11	17	,	,	,
cord-301755-fxfsr9bj	11	18	had	have	VBD
cord-301755-fxfsr9bj	11	19	two	two	CD
cord-301755-fxfsr9bj	11	20	point	point	NN
cord-301755-fxfsr9bj	11	21	mutations	mutation	NNS
cord-301755-fxfsr9bj	11	22	at	at	IN
cord-301755-fxfsr9bj	11	23	NT	NT	NNP
cord-301755-fxfsr9bj	11	24	1766	1766	CD
cord-301755-fxfsr9bj	11	25	and	and	CC
cord-301755-fxfsr9bj	11	26	1950	1950	CD
cord-301755-fxfsr9bj	11	27	,	,	,
cord-301755-fxfsr9bj	11	28	which	which	WDT
cord-301755-fxfsr9bj	11	29	were	be	VBD
cord-301755-fxfsr9bj	11	30	in	in	IN
cord-301755-fxfsr9bj	11	31	the	the	DT
cord-301755-fxfsr9bj	11	32	S1	S1	NNP
cord-301755-fxfsr9bj	11	33	subunit	subunit	NN
cord-301755-fxfsr9bj	11	34	.	.	.
cord-301755-fxfsr9bj	12	1	Finally	finally	RB
cord-301755-fxfsr9bj	12	2	,	,	,
cord-301755-fxfsr9bj	12	3	the	the	DT
cord-301755-fxfsr9bj	12	4	double	double	JJ
cord-301755-fxfsr9bj	12	5	mutant	mutant	NN
cord-301755-fxfsr9bj	12	6	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	12	7	,	,	,
cord-301755-fxfsr9bj	12	8	which	which	WDT
cord-301755-fxfsr9bj	12	9	was	be	VBD
cord-301755-fxfsr9bj	12	10	selected	select	VBN
cord-301755-fxfsr9bj	12	11	with	with	IN
cord-301755-fxfsr9bj	12	12	both	both	DT
cord-301755-fxfsr9bj	12	13	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	12	14	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	12	15	and	and	CC
cord-301755-fxfsr9bj	12	16	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	12	17	,	,	,
cord-301755-fxfsr9bj	12	18	and	and	CC
cord-301755-fxfsr9bj	12	19	was	be	VBD
cord-301755-fxfsr9bj	12	20	attenuated	attenuate	VBN
cord-301755-fxfsr9bj	12	21	with	with	IN
cord-301755-fxfsr9bj	12	22	respect	respect	NN
cord-301755-fxfsr9bj	12	23	to	to	IN
cord-301755-fxfsr9bj	12	24	both	both	DT
cord-301755-fxfsr9bj	12	25	virulence	virulence	NN
cord-301755-fxfsr9bj	12	26	and	and	CC
cord-301755-fxfsr9bj	12	27	the	the	DT
cord-301755-fxfsr9bj	12	28	ability	ability	NN
cord-301755-fxfsr9bj	12	29	to	to	TO
cord-301755-fxfsr9bj	12	30	cause	cause	VB
cord-301755-fxfsr9bj	12	31	demyelination	demyelination	NN
cord-301755-fxfsr9bj	12	32	,	,	,
cord-301755-fxfsr9bj	12	33	had	have	VBD
cord-301755-fxfsr9bj	12	34	a	a	DT
cord-301755-fxfsr9bj	12	35	deletion	deletion	NN
cord-301755-fxfsr9bj	12	36	spanning	span	VBG
cord-301755-fxfsr9bj	12	37	from	from	IN
cord-301755-fxfsr9bj	12	38	NT	NT	NNP
cord-301755-fxfsr9bj	12	39	1523	1523	CD
cord-301755-fxfsr9bj	12	40	to	to	IN
cord-301755-fxfsr9bj	12	41	1624	1624	CD
cord-301755-fxfsr9bj	12	42	in	in	IN
cord-301755-fxfsr9bj	12	43	the	the	DT
cord-301755-fxfsr9bj	12	44	S1	s1	NN
cord-301755-fxfsr9bj	12	45	and	and	CC
cord-301755-fxfsr9bj	12	46	a	a	DT
cord-301755-fxfsr9bj	12	47	point	point	NN
cord-301755-fxfsr9bj	12	48	mutation	mutation	NN
cord-301755-fxfsr9bj	12	49	at	at	IN
cord-301755-fxfsr9bj	12	50	NT	NT	NNP
cord-301755-fxfsr9bj	12	51	3340	3340	CD
cord-301755-fxfsr9bj	12	52	in	in	IN
cord-301755-fxfsr9bj	12	53	the	the	DT
cord-301755-fxfsr9bj	12	54	S2	s2	NN
cord-301755-fxfsr9bj	12	55	.	.	.
cord-301755-fxfsr9bj	13	1	We	-PRON-	PRP
cord-301755-fxfsr9bj	13	2	conclude	conclude	VBP
cord-301755-fxfsr9bj	13	3	that	that	IN
cord-301755-fxfsr9bj	13	4	at	at	RB
cord-301755-fxfsr9bj	13	5	least	least	RBS
cord-301755-fxfsr9bj	13	6	two	two	CD
cord-301755-fxfsr9bj	13	7	regions	region	NNS
cord-301755-fxfsr9bj	13	8	of	of	IN
cord-301755-fxfsr9bj	13	9	the	the	DT
cord-301755-fxfsr9bj	13	10	S	S	NNP
cord-301755-fxfsr9bj	13	11	protein	protein	NN
cord-301755-fxfsr9bj	13	12	contribute	contribute	VBP
cord-301755-fxfsr9bj	13	13	to	to	IN
cord-301755-fxfsr9bj	13	14	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	13	15	of	of	IN
cord-301755-fxfsr9bj	13	16	MHV	MHV	NNP
cord-301755-fxfsr9bj	13	17	.	.	.
cord-301755-fxfsr9bj	14	1	We	-PRON-	PRP
cord-301755-fxfsr9bj	14	2	have	have	VBP
cord-301755-fxfsr9bj	14	3	also	also	RB
cord-301755-fxfsr9bj	14	4	isolated	isolate	VBN
cord-301755-fxfsr9bj	14	5	a	a	DT
cord-301755-fxfsr9bj	14	6	partial	partial	JJ
cord-301755-fxfsr9bj	14	7	revertant	revertant	NN
cord-301755-fxfsr9bj	14	8	of	of	IN
cord-301755-fxfsr9bj	14	9	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	14	10	,	,	,
cord-301755-fxfsr9bj	14	11	which	which	WDT
cord-301755-fxfsr9bj	14	12	was	be	VBD
cord-301755-fxfsr9bj	14	13	partially	partially	RB
cord-301755-fxfsr9bj	14	14	resistant	resistant	JJ
cord-301755-fxfsr9bj	14	15	to	to	IN
cord-301755-fxfsr9bj	14	16	MAb	MAb	NNS
cord-301755-fxfsr9bj	14	17	1.2.2	1.2.2	CD
cord-301755-fxfsr9bj	14	18	but	but	CC
cord-301755-fxfsr9bj	14	19	retained	retain	VBD
cord-301755-fxfsr9bj	14	20	the	the	DT
cord-301755-fxfsr9bj	14	21	same	same	JJ
cord-301755-fxfsr9bj	14	22	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	14	23	as	as	IN
cord-301755-fxfsr9bj	14	24	the	the	DT
cord-301755-fxfsr9bj	14	25	variant	variant	JJ
cord-301755-fxfsr9bj	14	26	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	14	27	.	.	.
cord-301755-fxfsr9bj	15	1	This	this	DT
cord-301755-fxfsr9bj	15	2	revenant	revenant	NN
cord-301755-fxfsr9bj	15	3	retained	retain	VBD
cord-301755-fxfsr9bj	15	4	the	the	DT
cord-301755-fxfsr9bj	15	5	mutation	mutation	NN
cord-301755-fxfsr9bj	15	6	at	at	IN
cord-301755-fxfsr9bj	15	7	NT	NT	NNP
cord-301755-fxfsr9bj	15	8	3340	3340	CD
cord-301755-fxfsr9bj	15	9	,	,	,
cord-301755-fxfsr9bj	15	10	but	but	CC
cord-301755-fxfsr9bj	15	11	had	have	VBD
cord-301755-fxfsr9bj	15	12	a	a	DT
cord-301755-fxfsr9bj	15	13	second	second	JJ
cord-301755-fxfsr9bj	15	14	-	-	HYPH
cord-301755-fxfsr9bj	15	15	site	site	NN
cord-301755-fxfsr9bj	15	16	mutation	mutation	NN
cord-301755-fxfsr9bj	15	17	at	at	IN
cord-301755-fxfsr9bj	15	18	NT	NT	NNP
cord-301755-fxfsr9bj	15	19	1994	1994	CD
cord-301755-fxfsr9bj	15	20	,	,	,
cord-301755-fxfsr9bj	15	21	further	further	RB
cord-301755-fxfsr9bj	15	22	confirming	confirm	VBG
cord-301755-fxfsr9bj	15	23	that	that	IN
cord-301755-fxfsr9bj	15	24	NT	NT	NNP
cord-301755-fxfsr9bj	15	25	3340	3340	CD
cord-301755-fxfsr9bj	15	26	contributed	contribute	VBD
cord-301755-fxfsr9bj	15	27	to	to	IN
cord-301755-fxfsr9bj	15	28	the	the	DT
cord-301755-fxfsr9bj	15	29	pathogenic	pathogenic	JJ
cord-301755-fxfsr9bj	15	30	phenotype	phenotype	NN
cord-301755-fxfsr9bj	15	31	of	of	IN
cord-301755-fxfsr9bj	15	32	MHV	MHV	NNP
cord-301755-fxfsr9bj	15	33	.	.	.
cord-301755-fxfsr9bj	16	1	By	by	IN
cord-301755-fxfsr9bj	16	2	comparing	compare	VBG
cord-301755-fxfsr9bj	16	3	these	these	DT
cord-301755-fxfsr9bj	16	4	results	result	NNS
cord-301755-fxfsr9bj	16	5	with	with	IN
cord-301755-fxfsr9bj	16	6	MHV	MHV	NNP
cord-301755-fxfsr9bj	16	7	variants	variant	NNS
cord-301755-fxfsr9bj	16	8	isolated	isolate	VBN
cord-301755-fxfsr9bj	16	9	in	in	IN
cord-301755-fxfsr9bj	16	10	other	other	JJ
cord-301755-fxfsr9bj	16	11	laboratories	laboratory	NNS
cord-301755-fxfsr9bj	16	12	,	,	,
cord-301755-fxfsr9bj	16	13	which	which	WDT
cord-301755-fxfsr9bj	16	14	had	have	VBD
cord-301755-fxfsr9bj	16	15	mutations	mutation	NNS
cord-301755-fxfsr9bj	16	16	in	in	IN
cord-301755-fxfsr9bj	16	17	other	other	JJ
cord-301755-fxfsr9bj	16	18	sites	site	NNS
cord-301755-fxfsr9bj	16	19	on	on	IN
cord-301755-fxfsr9bj	16	20	the	the	DT
cord-301755-fxfsr9bj	16	21	S	S	NNP
cord-301755-fxfsr9bj	16	22	gene	gene	NN
cord-301755-fxfsr9bj	16	23	and	and	CC
cord-301755-fxfsr9bj	16	24	yet	yet	RB
cord-301755-fxfsr9bj	16	25	retained	retain	VBD
cord-301755-fxfsr9bj	16	26	the	the	DT
cord-301755-fxfsr9bj	16	27	demyelinating	demyelinating	JJ
cord-301755-fxfsr9bj	16	28	ability	ability	NN
cord-301755-fxfsr9bj	16	29	,	,	,
cord-301755-fxfsr9bj	16	30	we	-PRON-	PRP
cord-301755-fxfsr9bj	16	31	suggest	suggest	VBP
cord-301755-fxfsr9bj	16	32	that	that	IN
cord-301755-fxfsr9bj	16	33	the	the	DT
cord-301755-fxfsr9bj	16	34	ability	ability	NN
cord-301755-fxfsr9bj	16	35	of	of	IN
cord-301755-fxfsr9bj	16	36	JHM	JHM	NNP
cord-301755-fxfsr9bj	16	37	viruses	virus	NNS
cord-301755-fxfsr9bj	16	38	to	to	TO
cord-301755-fxfsr9bj	16	39	induce	induce	VB
cord-301755-fxfsr9bj	16	40	demyelination	demyelination	NN
cord-301755-fxfsr9bj	16	41	is	be	VBZ
cord-301755-fxfsr9bj	16	42	determined	determine	VBN
cord-301755-fxfsr9bj	16	43	by	by	IN
cord-301755-fxfsr9bj	16	44	the	the	DT
cord-301755-fxfsr9bj	16	45	interaction	interaction	NN
cord-301755-fxfsr9bj	16	46	of	of	IN
cord-301755-fxfsr9bj	16	47	multiple	multiple	JJ
cord-301755-fxfsr9bj	16	48	sites	site	NNS
cord-301755-fxfsr9bj	16	49	on	on	IN
cord-301755-fxfsr9bj	16	50	the	the	DT
cord-301755-fxfsr9bj	16	51	S	S	NNP
cord-301755-fxfsr9bj	16	52	gene	gene	NN
cord-301755-fxfsr9bj	16	53	,	,	,
cord-301755-fxfsr9bj	16	54	rather	rather	RB
cord-301755-fxfsr9bj	16	55	than	than	IN
cord-301755-fxfsr9bj	16	56	the	the	DT
cord-301755-fxfsr9bj	16	57	characteristics	characteristic	NNS
cord-301755-fxfsr9bj	16	58	of	of	IN
cord-301755-fxfsr9bj	16	59	a	a	DT
cord-301755-fxfsr9bj	16	60	single	single	JJ
cord-301755-fxfsr9bj	16	61	,	,	,
cord-301755-fxfsr9bj	16	62	unique	unique	JJ
cord-301755-fxfsr9bj	16	63	site	site	NN
cord-301755-fxfsr9bj	16	64	.	.	.
cord-301755-fxfsr9bj	17	1	Our	-PRON-	PRP$
cord-301755-fxfsr9bj	17	2	study	study	NN
cord-301755-fxfsr9bj	17	3	also	also	RB
cord-301755-fxfsr9bj	17	4	revealed	reveal	VBD
cord-301755-fxfsr9bj	17	5	the	the	DT
cord-301755-fxfsr9bj	17	6	possible	possible	JJ
cord-301755-fxfsr9bj	17	7	presence	presence	NN
cord-301755-fxfsr9bj	17	8	of	of	IN
cord-301755-fxfsr9bj	17	9	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	17	10	of	of	IN
cord-301755-fxfsr9bj	17	11	S	S	NNP
cord-301755-fxfsr9bj	17	12	gene	gene	NN
cord-301755-fxfsr9bj	17	13	sequence	sequence	NN
cord-301755-fxfsr9bj	17	14	,	,	,
cord-301755-fxfsr9bj	17	15	particularly	particularly	RB
cord-301755-fxfsr9bj	17	16	in	in	IN
cord-301755-fxfsr9bj	17	17	the	the	DT
cord-301755-fxfsr9bj	17	18	S1	S1	NNP
cord-301755-fxfsr9bj	17	19	region	region	NN
cord-301755-fxfsr9bj	17	20	,	,	,
cord-301755-fxfsr9bj	17	21	in	in	IN
cord-301755-fxfsr9bj	17	22	these	these	DT
cord-301755-fxfsr9bj	17	23	viruses	virus	NNS
cord-301755-fxfsr9bj	17	24	.	.	.
cord-301755-fxfsr9bj	18	1	The	the	DT
cord-301755-fxfsr9bj	18	2	sequence	sequence	NN
cord-301755-fxfsr9bj	18	3	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	18	4	may	may	MD
cord-301755-fxfsr9bj	18	5	also	also	RB
cord-301755-fxfsr9bj	18	6	contribute	contribute	VB
cord-301755-fxfsr9bj	18	7	to	to	IN
cord-301755-fxfsr9bj	18	8	the	the	DT
cord-301755-fxfsr9bj	18	9	differences	difference	NNS
cord-301755-fxfsr9bj	18	10	in	in	IN
cord-301755-fxfsr9bj	18	11	their	-PRON-	PRP$
cord-301755-fxfsr9bj	18	12	biological	biological	JJ
cord-301755-fxfsr9bj	18	13	properties	property	NNS
cord-301755-fxfsr9bj	18	14	.	.	.
cord-301755-fxfsr9bj	19	1	Mouse	Mouse	NNP
cord-301755-fxfsr9bj	19	2	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	19	3	virus	virus	NN
cord-301755-fxfsr9bj	19	4	(	(	-LRB-
cord-301755-fxfsr9bj	19	5	MHV	MHV	NNP
cord-301755-fxfsr9bj	19	6	)	)	-RRB-
cord-301755-fxfsr9bj	19	7	is	be	VBZ
cord-301755-fxfsr9bj	19	8	a	a	DT
cord-301755-fxfsr9bj	19	9	prototypic	prototypic	JJ
cord-301755-fxfsr9bj	19	10	member	member	NN
cord-301755-fxfsr9bj	19	11	of	of	IN
cord-301755-fxfsr9bj	19	12	the	the	DT
cord-301755-fxfsr9bj	19	13	Coronaviridae	Coronaviridae	NNP
cord-301755-fxfsr9bj	19	14	.	.	.
cord-301755-fxfsr9bj	20	1	The	the	DT
cord-301755-fxfsr9bj	20	2	virus	virus	NN
cord-301755-fxfsr9bj	20	3	is	be	VBZ
cord-301755-fxfsr9bj	20	4	enveloped	envelop	VBN
cord-301755-fxfsr9bj	20	5	and	and	CC
cord-301755-fxfsr9bj	20	6	contains	contain	VBZ
cord-301755-fxfsr9bj	20	7	a	a	DT
cord-301755-fxfsr9bj	20	8	single	single	JJ
cord-301755-fxfsr9bj	20	9	-	-	HYPH
cord-301755-fxfsr9bj	20	10	stranded	stranded	JJ
cord-301755-fxfsr9bj	20	11	,	,	,
cord-301755-fxfsr9bj	20	12	positive	positive	JJ
cord-301755-fxfsr9bj	20	13	-	-	HYPH
cord-301755-fxfsr9bj	20	14	sensed	sensed	JJ
cord-301755-fxfsr9bj	20	15	,	,	,
cord-301755-fxfsr9bj	20	16	and	and	CC
cord-301755-fxfsr9bj	20	17	nonsegmented	nonsegmente	VBD
cord-301755-fxfsr9bj	20	18	RNA	RNA	NNP
cord-301755-fxfsr9bj	20	19	genome	genome	NN
cord-301755-fxfsr9bj	20	20	of	of	IN
cord-301755-fxfsr9bj	20	21	31	31	CD
cord-301755-fxfsr9bj	20	22	kb	kb	NNS
cord-301755-fxfsr9bj	20	23	in	in	IN
cord-301755-fxfsr9bj	20	24	length	length	NN
cord-301755-fxfsr9bj	21	1	(	(	-LRB-
cord-301755-fxfsr9bj	21	2	Lai	Lai	NNP
cord-301755-fxfsr9bj	21	3	and	and	CC
cord-301755-fxfsr9bj	21	4	Stohlman	Stohlman	NNP
cord-301755-fxfsr9bj	21	5	,	,	,
cord-301755-fxfsr9bj	21	6	1978	1978	CD
cord-301755-fxfsr9bj	21	7	;	;	:
cord-301755-fxfsr9bj	21	8	Pachuk	Pachuk	NNP
cord-301755-fxfsr9bj	21	9	et	et	NNP
cord-301755-fxfsr9bj	21	10	al	al	NNP
cord-301755-fxfsr9bj	21	11	.	.	NNP
cord-301755-fxfsr9bj	21	12	,	,	,
cord-301755-fxfsr9bj	21	13	1989	1989	CD
cord-301755-fxfsr9bj	21	14	;	;	:
cord-301755-fxfsr9bj	21	15	Lee	Lee	NNP
cord-301755-fxfsr9bj	21	16	er	er	UH
cord-301755-fxfsr9bj	21	17	al	al	NNP
cord-301755-fxfsr9bj	21	18	.	.	NNP
cord-301755-fxfsr9bj	21	19	,	,	,
cord-301755-fxfsr9bj	21	20	1991	1991	CD
cord-301755-fxfsr9bj	21	21	)	)	-RRB-
cord-301755-fxfsr9bj	21	22	.	.	.
cord-301755-fxfsr9bj	22	1	The	the	DT
cord-301755-fxfsr9bj	22	2	virus	virus	NN
cord-301755-fxfsr9bj	22	3	particle	particle	NN
cord-301755-fxfsr9bj	22	4	contains	contain	VBZ
cord-301755-fxfsr9bj	22	5	three	three	CD
cord-301755-fxfsr9bj	22	6	envelope	envelope	NN
cord-301755-fxfsr9bj	22	7	glycoproteins	glycoprotein	NNS
cord-301755-fxfsr9bj	22	8	(	(	-LRB-
cord-301755-fxfsr9bj	22	9	S	S	NNP
cord-301755-fxfsr9bj	22	10	,	,	,
cord-301755-fxfsr9bj	22	11	M	M	NNP
cord-301755-fxfsr9bj	22	12	,	,	,
cord-301755-fxfsr9bj	22	13	and	and	CC
cord-301755-fxfsr9bj	22	14	HE	HE	NNP
cord-301755-fxfsr9bj	22	15	)	)	-RRB-
cord-301755-fxfsr9bj	22	16	and	and	CC
cord-301755-fxfsr9bj	22	17	an	an	DT
cord-301755-fxfsr9bj	22	18	internal	internal	JJ
cord-301755-fxfsr9bj	22	19	nucleocapsid	nucleocapsid	NN
cord-301755-fxfsr9bj	22	20	protein	protein	NNP
cord-301755-fxfsr9bj	22	21	(	(	-LRB-
cord-301755-fxfsr9bj	22	22	N	N	NNP
cord-301755-fxfsr9bj	22	23	)	)	-RRB-
cord-301755-fxfsr9bj	22	24	.	.	.
cord-301755-fxfsr9bj	23	1	The	the	DT
cord-301755-fxfsr9bj	23	2	S	S	NNP
cord-301755-fxfsr9bj	23	3	(	(	-LRB-
cord-301755-fxfsr9bj	23	4	spike	spike	NN
cord-301755-fxfsr9bj	23	5	)	)	-RRB-
cord-301755-fxfsr9bj	23	6	protein	protein	NN
cord-301755-fxfsr9bj	23	7	of	of	IN
cord-301755-fxfsr9bj	23	8	180	180	CD
cord-301755-fxfsr9bj	23	9	kDa	kDa	NNPS
cord-301755-fxfsr9bj	23	10	forms	form	VBZ
cord-301755-fxfsr9bj	23	11	peplomers	peplomer	NNS
cord-301755-fxfsr9bj	23	12	on	on	IN
cord-301755-fxfsr9bj	23	13	the	the	DT
cord-301755-fxfsr9bj	23	14	virion	virion	NN
cord-301755-fxfsr9bj	23	15	surface	surface	NN
cord-301755-fxfsr9bj	23	16	and	and	CC
cord-301755-fxfsr9bj	23	17	is	be	VBZ
cord-301755-fxfsr9bj	23	18	responsible	responsible	JJ
cord-301755-fxfsr9bj	23	19	for	for	IN
cord-301755-fxfsr9bj	23	20	the	the	DT
cord-301755-fxfsr9bj	23	21	viral	viral	JJ
cord-301755-fxfsr9bj	23	22	attachment	attachment	NN
cord-301755-fxfsr9bj	23	23	to	to	IN
cord-301755-fxfsr9bj	23	24	cellular	cellular	JJ
cord-301755-fxfsr9bj	23	25	receptors	receptor	NNS
cord-301755-fxfsr9bj	23	26	,	,	,
cord-301755-fxfsr9bj	23	27	the	the	DT
cord-301755-fxfsr9bj	23	28	elicitation	elicitation	NN
cord-301755-fxfsr9bj	23	29	of	of	IN
cord-301755-fxfsr9bj	23	30	neutralizing	neutralize	VBG
cord-301755-fxfsr9bj	23	31	antibodies	antibody	NNS
cord-301755-fxfsr9bj	23	32	,	,	,
cord-301755-fxfsr9bj	23	33	and	and	CC
cord-301755-fxfsr9bj	23	34	the	the	DT
cord-301755-fxfsr9bj	23	35	induction	induction	NN
cord-301755-fxfsr9bj	23	36	of	of	IN
cord-301755-fxfsr9bj	23	37	cell	cell	NN
cord-301755-fxfsr9bj	23	38	-	-	HYPH
cord-301755-fxfsr9bj	23	39	to	to	IN
cord-301755-fxfsr9bj	23	40	-	-	HYPH
cord-301755-fxfsr9bj	23	41	cell	cell	NN
cord-301755-fxfsr9bj	23	42	fusion	fusion	NN
cord-301755-fxfsr9bj	23	43	(	(	-LRB-
cord-301755-fxfsr9bj	23	44	Collins	Collins	NNP
cord-301755-fxfsr9bj	23	45	eta/.	eta/.	CD
cord-301755-fxfsr9bj	23	46	,	,	,
cord-301755-fxfsr9bj	23	47	1982	1982	CD
cord-301755-fxfsr9bj	23	48	;	;	:
cord-301755-fxfsr9bj	23	49	Sturman	Sturman	NNP
cord-301755-fxfsr9bj	23	50	eta/.	eta/.	NNP
cord-301755-fxfsr9bj	23	51	,	,	,
cord-301755-fxfsr9bj	23	52	1985	1985	CD
cord-301755-fxfsr9bj	23	53	)	)	-RRB-
cord-301755-fxfsr9bj	23	54	.	.	.
cord-301755-fxfsr9bj	24	1	Alterations	alteration	NNS
cord-301755-fxfsr9bj	24	2	in	in	IN
cord-301755-fxfsr9bj	24	3	the	the	DT
cord-301755-fxfsr9bj	24	4	S	S	NNP
cord-301755-fxfsr9bj	24	5	protein	protein	NN
cord-301755-fxfsr9bj	24	6	resulted	result	VBD
cord-301755-fxfsr9bj	24	7	in	in	IN
cord-301755-fxfsr9bj	24	8	changes	change	NNS
cord-301755-fxfsr9bj	24	9	in	in	IN
cord-301755-fxfsr9bj	24	10	viral	viral	JJ
cord-301755-fxfsr9bj	24	11	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	24	12	,	,	,
cord-301755-fxfsr9bj	24	13	as	as	IN
cord-301755-fxfsr9bj	24	14	demonstrated	demonstrate	VBN
cord-301755-fxfsr9bj	24	15	by	by	IN
cord-301755-fxfsr9bj	24	16	neutralization	neutralization	NN
cord-301755-fxfsr9bj	24	17	-	-	HYPH
cord-301755-fxfsr9bj	24	18	escape	escape	NN
cord-301755-fxfsr9bj	24	19	mutants	mutant	NNS
cord-301755-fxfsr9bj	24	20	se-	se-	VBP
cord-301755-fxfsr9bj	24	21	'	'	''
cord-301755-fxfsr9bj	24	22	Current	current	JJ
cord-301755-fxfsr9bj	24	23	address	address	NN
cord-301755-fxfsr9bj	24	24	:	:	:
cord-301755-fxfsr9bj	24	25	Departments	department	NNS
cord-301755-fxfsr9bj	24	26	of	of	IN
cord-301755-fxfsr9bj	24	27	Neurology	Neurology	NNP
cord-301755-fxfsr9bj	24	28	and	and	CC
cord-301755-fxfsr9bj	24	29	Medical	Medical	NNP
cord-301755-fxfsr9bj	24	30	Microbiology	Microbiology	NNP
cord-301755-fxfsr9bj	24	31	and	and	CC
cord-301755-fxfsr9bj	24	32	Immunology	Immunology	NNP
cord-301755-fxfsr9bj	24	33	,	,	,
cord-301755-fxfsr9bj	24	34	School	School	NNP
cord-301755-fxfsr9bj	24	35	of	of	IN
cord-301755-fxfsr9bj	24	36	Medicine	Medicine	NNP
cord-301755-fxfsr9bj	24	37	,	,	,
cord-301755-fxfsr9bj	24	38	University	University	NNP
cord-301755-fxfsr9bj	24	39	of	of	IN
cord-301755-fxfsr9bj	24	40	Wisconsin	Wisconsin	NNP
cord-301755-fxfsr9bj	24	41	at	at	IN
cord-301755-fxfsr9bj	24	42	Madison	Madison	NNP
cord-301755-fxfsr9bj	24	43	,	,	,
cord-301755-fxfsr9bj	24	44	Madison	Madison	NNP
cord-301755-fxfsr9bj	24	45	,	,	,
cord-301755-fxfsr9bj	24	46	WI	WI	NNP
cord-301755-fxfsr9bj	24	47	53792	53792	CD
cord-301755-fxfsr9bj	24	48	.	.	.
cord-301755-fxfsr9bj	24	49	'	'	''
cord-301755-fxfsr9bj	25	1	To	to	TO
cord-301755-fxfsr9bj	25	2	whom	whom	WP
cord-301755-fxfsr9bj	25	3	correspondence	correspondence	NN
cord-301755-fxfsr9bj	25	4	and	and	CC
cord-301755-fxfsr9bj	25	5	reprint	reprint	NN
cord-301755-fxfsr9bj	25	6	requests	request	NNS
cord-301755-fxfsr9bj	25	7	should	should	MD
cord-301755-fxfsr9bj	25	8	be	be	VB
cord-301755-fxfsr9bj	25	9	addressed	address	VBN
cord-301755-fxfsr9bj	25	10	.	.	.
cord-301755-fxfsr9bj	26	1	Q	Q	NNP
cord-301755-fxfsr9bj	26	2	1992	1992	CD
cord-301755-fxfsr9bj	26	3	Academic	Academic	NNP
cord-301755-fxfsr9bj	26	4	Press	Press	NNP
cord-301755-fxfsr9bj	26	5	,	,	,
cord-301755-fxfsr9bj	26	6	Inc.	Inc.	NNP
cord-301755-fxfsr9bj	26	7	lected	lecte	VBD
cord-301755-fxfsr9bj	26	8	with	with	IN
cord-301755-fxfsr9bj	26	9	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	26	10	antibodies	antibody	NNS
cord-301755-fxfsr9bj	26	11	(	(	-LRB-
cord-301755-fxfsr9bj	26	12	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	26	13	)	)	-RRB-
cord-301755-fxfsr9bj	26	14	specific	specific	JJ
cord-301755-fxfsr9bj	26	15	for	for	IN
cord-301755-fxfsr9bj	26	16	the	the	DT
cord-301755-fxfsr9bj	26	17	S	S	NNP
cord-301755-fxfsr9bj	26	18	protein	protein	NN
cord-301755-fxfsr9bj	26	19	(	(	-LRB-
cord-301755-fxfsr9bj	26	20	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	26	21	et	et	NNP
cord-301755-fxfsr9bj	26	22	a/.	a/.	NNP
cord-301755-fxfsr9bj	26	23	,	,	,
cord-301755-fxfsr9bj	26	24	1986	1986	CD
cord-301755-fxfsr9bj	27	1	(	(	-LRB-
cord-301755-fxfsr9bj	27	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	27	3	et	et	NNP
cord-301755-fxfsr9bj	27	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	27	5	,	,	,
cord-301755-fxfsr9bj	27	6	,	,	,
cord-301755-fxfsr9bj	27	7	1987	1987	CD
cord-301755-fxfsr9bj	28	1	Dalziel	Dalziel	NNP
cord-301755-fxfsr9bj	28	2	et	et	NNP
cord-301755-fxfsr9bj	28	3	al	al	NNP
cord-301755-fxfsr9bj	28	4	.	.	.
cord-301755-fxfsr9bj	29	1	,	,	,
cord-301755-fxfsr9bj	29	2	1986	1986	CD
cord-301755-fxfsr9bj	29	3	;	;	:
cord-301755-fxfsr9bj	29	4	Wege	Wege	NNP
cord-301755-fxfsr9bj	29	5	et	et	NNP
cord-301755-fxfsr9bj	29	6	a/.	a/.	NNP
cord-301755-fxfsr9bj	29	7	,	,	,
cord-301755-fxfsr9bj	29	8	1988	1988	CD
cord-301755-fxfsr9bj	29	9	)	)	-RRB-
cord-301755-fxfsr9bj	29	10	.	.	.
cord-301755-fxfsr9bj	30	1	Furthermore	furthermore	RB
cord-301755-fxfsr9bj	30	2	,	,	,
cord-301755-fxfsr9bj	30	3	passive	passive	JJ
cord-301755-fxfsr9bj	30	4	immunization	immunization	NN
cord-301755-fxfsr9bj	30	5	with	with	IN
cord-301755-fxfsr9bj	30	6	S	s	NN
cord-301755-fxfsr9bj	30	7	-	-	HYPH
cord-301755-fxfsr9bj	30	8	specific	specific	JJ
cord-301755-fxfsr9bj	30	9	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	30	10	antibodies	antibody	NNS
cord-301755-fxfsr9bj	30	11	also	also	RB
cord-301755-fxfsr9bj	30	12	altered	alter	VBD
cord-301755-fxfsr9bj	30	13	viral	viral	JJ
cord-301755-fxfsr9bj	30	14	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	30	15	(	(	-LRB-
cord-301755-fxfsr9bj	30	16	Buchmeier	Buchmeier	NNP
cord-301755-fxfsr9bj	30	17	et	et	NNP
cord-301755-fxfsr9bj	30	18	a/.	a/.	NN
cord-301755-fxfsr9bj	30	19	,	,	,
cord-301755-fxfsr9bj	30	20	1984	1984	CD
cord-301755-fxfsr9bj	30	21	)	)	-RRB-
cord-301755-fxfsr9bj	30	22	.	.	.
cord-301755-fxfsr9bj	31	1	The	the	DT
cord-301755-fxfsr9bj	31	2	S	S	NNP
cord-301755-fxfsr9bj	31	3	protein	protein	NN
cord-301755-fxfsr9bj	31	4	is	be	VBZ
cord-301755-fxfsr9bj	31	5	cleaved	cleave	VBN
cord-301755-fxfsr9bj	31	6	into	into	IN
cord-301755-fxfsr9bj	31	7	two	two	CD
cord-301755-fxfsr9bj	31	8	90-kDa	90-kda	CD
cord-301755-fxfsr9bj	31	9	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	31	10	subunits	subunit	NNS
cord-301755-fxfsr9bj	31	11	(	(	-LRB-
cord-301755-fxfsr9bj	31	12	Sl	Sl	NNP
cord-301755-fxfsr9bj	31	13	and	and	CC
cord-301755-fxfsr9bj	31	14	S2	S2	NNP
cord-301755-fxfsr9bj	31	15	)	)	-RRB-
cord-301755-fxfsr9bj	31	16	.	.	.
cord-301755-fxfsr9bj	32	1	Its	-PRON-	PRP$
cord-301755-fxfsr9bj	32	2	cleavage	cleavage	NN
cord-301755-fxfsr9bj	32	3	is	be	VBZ
cord-301755-fxfsr9bj	32	4	carried	carry	VBN
cord-301755-fxfsr9bj	32	5	out	out	RP
cord-301755-fxfsr9bj	32	6	by	by	IN
cord-301755-fxfsr9bj	32	7	a	a	DT
cord-301755-fxfsr9bj	32	8	cellular	cellular	JJ
cord-301755-fxfsr9bj	32	9	protease	protease	NN
cord-301755-fxfsr9bj	32	10	and	and	CC
cord-301755-fxfsr9bj	32	11	is	be	VBZ
cord-301755-fxfsr9bj	32	12	probably	probably	RB
cord-301755-fxfsr9bj	32	13	required	require	VBN
cord-301755-fxfsr9bj	32	14	for	for	IN
cord-301755-fxfsr9bj	32	15	the	the	DT
cord-301755-fxfsr9bj	32	16	virusinduced	virusinduced	JJ
cord-301755-fxfsr9bj	32	17	cell	cell	NN
cord-301755-fxfsr9bj	32	18	fusion	fusion	NN
cord-301755-fxfsr9bj	32	19	(	(	-LRB-
cord-301755-fxfsr9bj	32	20	Storz	Storz	NNP
cord-301755-fxfsr9bj	32	21	et	et	NNP
cord-301755-fxfsr9bj	32	22	a/.	a/.	NNP
cord-301755-fxfsr9bj	32	23	,	,	,
cord-301755-fxfsr9bj	32	24	1981	1981	CD
cord-301755-fxfsr9bj	32	25	;	;	:
cord-301755-fxfsr9bj	33	1	Yoshikura	Yoshikura	NNP
cord-301755-fxfsr9bj	33	2	and	and	CC
cord-301755-fxfsr9bj	33	3	Tajima	Tajima	NNP
cord-301755-fxfsr9bj	33	4	,	,	,
cord-301755-fxfsr9bj	33	5	1981	1981	CD
cord-301755-fxfsr9bj	33	6	;	;	:
cord-301755-fxfsr9bj	33	7	Sturman	Sturman	NNP
cord-301755-fxfsr9bj	33	8	et	et	NNP
cord-301755-fxfsr9bj	33	9	al	al	NNP
cord-301755-fxfsr9bj	33	10	.	.	NNP
cord-301755-fxfsr9bj	33	11	,	,	,
cord-301755-fxfsr9bj	33	12	1985	1985	CD
cord-301755-fxfsr9bj	33	13	)	)	-RRB-
cord-301755-fxfsr9bj	33	14	.	.	.
cord-301755-fxfsr9bj	34	1	The	the	DT
cord-301755-fxfsr9bj	34	2	S	S	NNP
cord-301755-fxfsr9bj	34	3	protein	protein	NN
cord-301755-fxfsr9bj	34	4	is	be	VBZ
cord-301755-fxfsr9bj	34	5	translated	translate	VBN
cord-301755-fxfsr9bj	34	6	from	from	IN
cord-301755-fxfsr9bj	34	7	mRNA	mRNA	NNP
cord-301755-fxfsr9bj	34	8	3	3	CD
cord-301755-fxfsr9bj	34	9	,	,	,
cord-301755-fxfsr9bj	34	10	which	which	WDT
cord-301755-fxfsr9bj	34	11	represents	represent	VBZ
cord-301755-fxfsr9bj	34	12	the	the	DT
cord-301755-fxfsr9bj	34	13	transcript	transcript	NN
cord-301755-fxfsr9bj	34	14	of	of	IN
cord-301755-fxfsr9bj	34	15	the	the	DT
cord-301755-fxfsr9bj	34	16	4.2-kb	4.2-kb	CD
cord-301755-fxfsr9bj	34	17	gene	gene	NN
cord-301755-fxfsr9bj	34	18	(	(	-LRB-
cord-301755-fxfsr9bj	34	19	S	S	NNP
cord-301755-fxfsr9bj	34	20	gene	gene	NN
cord-301755-fxfsr9bj	34	21	)	)	-RRB-
cord-301755-fxfsr9bj	34	22	,	,	,
cord-301755-fxfsr9bj	34	23	located	locate	VBN
cord-301755-fxfsr9bj	34	24	at	at	IN
cord-301755-fxfsr9bj	34	25	roughly	roughly	RB
cord-301755-fxfsr9bj	34	26	6	6	CD
cord-301755-fxfsr9bj	34	27	-	-	SYM
cord-301755-fxfsr9bj	34	28	10	10	CD
cord-301755-fxfsr9bj	34	29	kb	kb	NNS
cord-301755-fxfsr9bj	34	30	from	from	IN
cord-301755-fxfsr9bj	34	31	the	the	DT
cord-301755-fxfsr9bj	34	32	3'-end	3'-end	CD
cord-301755-fxfsr9bj	34	33	of	of	IN
cord-301755-fxfsr9bj	34	34	the	the	DT
cord-301755-fxfsr9bj	34	35	RNA	RNA	NNP
cord-301755-fxfsr9bj	34	36	genome	genome	NN
cord-301755-fxfsr9bj	34	37	(	(	-LRB-
cord-301755-fxfsr9bj	34	38	Lai	Lai	NNP
cord-301755-fxfsr9bj	34	39	,	,	,
cord-301755-fxfsr9bj	34	40	1990	1990	CD
cord-301755-fxfsr9bj	34	41	)	)	-RRB-
cord-301755-fxfsr9bj	34	42	.	.	.
cord-301755-fxfsr9bj	35	1	The	the	DT
cord-301755-fxfsr9bj	35	2	complete	complete	JJ
cord-301755-fxfsr9bj	35	3	sequence	sequence	NN
cord-301755-fxfsr9bj	35	4	of	of	IN
cord-301755-fxfsr9bj	35	5	the	the	DT
cord-301755-fxfsr9bj	35	6	S	S	NNP
cord-301755-fxfsr9bj	35	7	gene	gene	NN
cord-301755-fxfsr9bj	35	8	has	have	VBZ
cord-301755-fxfsr9bj	35	9	been	be	VBN
cord-301755-fxfsr9bj	35	10	reported	report	VBN
cord-301755-fxfsr9bj	35	11	for	for	IN
cord-301755-fxfsr9bj	35	12	three	three	CD
cord-301755-fxfsr9bj	35	13	strains	strain	NNS
cord-301755-fxfsr9bj	35	14	of	of	IN
cord-301755-fxfsr9bj	35	15	MHV	MHV	NNP
cord-301755-fxfsr9bj	35	16	,	,	,
cord-301755-fxfsr9bj	35	17	namely	namely	RB
cord-301755-fxfsr9bj	35	18	,	,	,
cord-301755-fxfsr9bj	35	19	A59	A59	NNP
cord-301755-fxfsr9bj	35	20	(	(	-LRB-
cord-301755-fxfsr9bj	35	21	Luytjes	Luytjes	NNP
cord-301755-fxfsr9bj	35	22	et	et	NNP
cord-301755-fxfsr9bj	35	23	a/.	a/.	NN
cord-301755-fxfsr9bj	35	24	,	,	,
cord-301755-fxfsr9bj	35	25	1987	1987	CD
cord-301755-fxfsr9bj	35	26	)	)	-RRB-
cord-301755-fxfsr9bj	36	1	JHM	JHM	NNP
cord-301755-fxfsr9bj	36	2	(	(	-LRB-
cord-301755-fxfsr9bj	36	3	Schmidt	Schmidt	NNP
cord-301755-fxfsr9bj	36	4	et	et	NNP
cord-301755-fxfsr9bj	36	5	a/.	a/.	NNP
cord-301755-fxfsr9bj	36	6	,	,	,
cord-301755-fxfsr9bj	36	7	1987	1987	CD
cord-301755-fxfsr9bj	36	8	)	)	-RRB-
cord-301755-fxfsr9bj	36	9	,	,	,
cord-301755-fxfsr9bj	36	10	and	and	CC
cord-301755-fxfsr9bj	36	11	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	36	12	(	(	-LRB-
cord-301755-fxfsr9bj	36	13	equivalent	equivalent	JJ
cord-301755-fxfsr9bj	36	14	to	to	IN
cord-301755-fxfsr9bj	36	15	JHM	JHM	NNP
cord-301755-fxfsr9bj	36	16	used	use	VBN
cord-301755-fxfsr9bj	36	17	in	in	IN
cord-301755-fxfsr9bj	36	18	our	-PRON-	PRP$
cord-301755-fxfsr9bj	36	19	laboratory	laboratory	NN
cord-301755-fxfsr9bj	36	20	)	)	-RRB-
cord-301755-fxfsr9bj	37	1	(	(	-LRB-
cord-301755-fxfsr9bj	37	2	Parker	Parker	NNP
cord-301755-fxfsr9bj	37	3	et	et	NNP
cord-301755-fxfsr9bj	37	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	37	5	,	,	,
cord-301755-fxfsr9bj	37	6	1989	1989	CD
cord-301755-fxfsr9bj	37	7	)	)	-RRB-
cord-301755-fxfsr9bj	37	8	.	.	.
cord-301755-fxfsr9bj	38	1	It	-PRON-	PRP
cord-301755-fxfsr9bj	38	2	appears	appear	VBZ
cord-301755-fxfsr9bj	38	3	that	that	IN
cord-301755-fxfsr9bj	38	4	the	the	DT
cord-301755-fxfsr9bj	38	5	S	S	NNP
cord-301755-fxfsr9bj	38	6	gene	gene	NN
cord-301755-fxfsr9bj	38	7	sequences	sequence	NNS
cord-301755-fxfsr9bj	38	8	of	of	IN
cord-301755-fxfsr9bj	38	9	different	different	JJ
cord-301755-fxfsr9bj	38	10	MHV	MHV	NNP
cord-301755-fxfsr9bj	38	11	strains	strain	NNS
cord-301755-fxfsr9bj	38	12	differ	differ	VBP
cord-301755-fxfsr9bj	38	13	significantly	significantly	RB
cord-301755-fxfsr9bj	38	14	,	,	,
cord-301755-fxfsr9bj	38	15	with	with	IN
cord-301755-fxfsr9bj	38	16	various	various	JJ
cord-301755-fxfsr9bj	38	17	degrees	degree	NNS
cord-301755-fxfsr9bj	38	18	of	of	IN
cord-301755-fxfsr9bj	38	19	deletion	deletion	NN
cord-301755-fxfsr9bj	38	20	and	and	CC
cord-301755-fxfsr9bj	38	21	substitutions	substitution	NNS
cord-301755-fxfsr9bj	38	22	.	.	.
cord-301755-fxfsr9bj	39	1	Infection	infection	NN
cord-301755-fxfsr9bj	39	2	of	of	IN
cord-301755-fxfsr9bj	39	3	the	the	DT
cord-301755-fxfsr9bj	39	4	central	central	JJ
cord-301755-fxfsr9bj	39	5	nervous	nervous	JJ
cord-301755-fxfsr9bj	39	6	system	system	NN
cord-301755-fxfsr9bj	39	7	(	(	-LRB-
cord-301755-fxfsr9bj	39	8	CNS	CNS	NNP
cord-301755-fxfsr9bj	39	9	)	)	-RRB-
cord-301755-fxfsr9bj	39	10	of	of	IN
cord-301755-fxfsr9bj	39	11	rodents	rodent	NNS
cord-301755-fxfsr9bj	39	12	by	by	IN
cord-301755-fxfsr9bj	39	13	MHV	MHV	NNP
cord-301755-fxfsr9bj	39	14	,	,	,
cord-301755-fxfsr9bj	39	15	particularly	particularly	RB
cord-301755-fxfsr9bj	39	16	the	the	DT
cord-301755-fxfsr9bj	39	17	JHM	JHM	NNP
cord-301755-fxfsr9bj	39	18	strain	strain	NN
cord-301755-fxfsr9bj	39	19	,	,	,
cord-301755-fxfsr9bj	39	20	has	have	VBZ
cord-301755-fxfsr9bj	39	21	been	be	VBN
cord-301755-fxfsr9bj	39	22	used	use	VBN
cord-301755-fxfsr9bj	39	23	as	as	IN
cord-301755-fxfsr9bj	39	24	a	a	DT
cord-301755-fxfsr9bj	39	25	model	model	NN
cord-301755-fxfsr9bj	39	26	system	system	NN
cord-301755-fxfsr9bj	39	27	for	for	IN
cord-301755-fxfsr9bj	39	28	studying	study	VBG
cord-301755-fxfsr9bj	39	29	human	human	JJ
cord-301755-fxfsr9bj	39	30	demyelinating	demyelinate	VBG
cord-301755-fxfsr9bj	39	31	diseases	disease	NNS
cord-301755-fxfsr9bj	39	32	,	,	,
cord-301755-fxfsr9bj	39	33	such	such	JJ
cord-301755-fxfsr9bj	39	34	as	as	IN
cord-301755-fxfsr9bj	39	35	multiple	multiple	JJ
cord-301755-fxfsr9bj	39	36	sclerosis	sclerosis	NN
cord-301755-fxfsr9bj	39	37	.	.	.
cord-301755-fxfsr9bj	40	1	Parental	parental	JJ
cord-301755-fxfsr9bj	40	2	JHM	JHM	NNP
cord-301755-fxfsr9bj	40	3	strain	strain	NN
cord-301755-fxfsr9bj	40	4	shows	show	VBZ
cord-301755-fxfsr9bj	40	5	tropism	tropism	NN
cord-301755-fxfsr9bj	40	6	for	for	IN
cord-301755-fxfsr9bj	40	7	both	both	DT
cord-301755-fxfsr9bj	40	8	neurons	neuron	NNS
cord-301755-fxfsr9bj	40	9	and	and	CC
cord-301755-fxfsr9bj	40	10	glial	glial	JJ
cord-301755-fxfsr9bj	40	11	cells	cell	NNS
cord-301755-fxfsr9bj	40	12	,	,	,
cord-301755-fxfsr9bj	40	13	causing	cause	VBG
cord-301755-fxfsr9bj	40	14	both	both	CC
cord-301755-fxfsr9bj	40	15	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	40	16	and	and	CC
cord-301755-fxfsr9bj	40	17	chronic	chronic	JJ
cord-301755-fxfsr9bj	40	18	demyelination	demyelination	NN
cord-301755-fxfsr9bj	40	19	(	(	-LRB-
cord-301755-fxfsr9bj	40	20	Weiner	Weiner	NNP
cord-301755-fxfsr9bj	40	21	,	,	,
cord-301755-fxfsr9bj	40	22	1973	1973	CD
cord-301755-fxfsr9bj	40	23	)	)	-RRB-
cord-301755-fxfsr9bj	40	24	.	.	.
cord-301755-fxfsr9bj	41	1	The	the	DT
cord-301755-fxfsr9bj	41	2	tropism	tropism	NN
cord-301755-fxfsr9bj	41	3	of	of	IN
cord-301755-fxfsr9bj	41	4	MHV	MHV	NNP
cord-301755-fxfsr9bj	41	5	is	be	VBZ
cord-301755-fxfsr9bj	41	6	mainly	mainly	RB
cord-301755-fxfsr9bj	41	7	determined	determine	VBN
cord-301755-fxfsr9bj	41	8	by	by	IN
cord-301755-fxfsr9bj	41	9	the	the	DT
cord-301755-fxfsr9bj	41	10	properties	property	NNS
cord-301755-fxfsr9bj	41	11	of	of	IN
cord-301755-fxfsr9bj	41	12	the	the	DT
cord-301755-fxfsr9bj	41	13	S	S	NNP
cord-301755-fxfsr9bj	41	14	protein	protein	NN
cord-301755-fxfsr9bj	41	15	,	,	,
cord-301755-fxfsr9bj	41	16	since	since	IN
cord-301755-fxfsr9bj	41	17	it	-PRON-	PRP
cord-301755-fxfsr9bj	41	18	is	be	VBZ
cord-301755-fxfsr9bj	41	19	the	the	DT
cord-301755-fxfsr9bj	41	20	outermost	outermost	JJS
cord-301755-fxfsr9bj	41	21	component	component	NN
cord-301755-fxfsr9bj	41	22	of	of	IN
cord-301755-fxfsr9bj	41	23	the	the	DT
cord-301755-fxfsr9bj	41	24	viral	viral	JJ
cord-301755-fxfsr9bj	41	25	envelope	envelope	NN
cord-301755-fxfsr9bj	41	26	,	,	,
cord-301755-fxfsr9bj	41	27	which	which	WDT
cord-301755-fxfsr9bj	41	28	interacts	interact	VBZ
cord-301755-fxfsr9bj	41	29	with	with	IN
cord-301755-fxfsr9bj	41	30	the	the	DT
cord-301755-fxfsr9bj	41	31	cellular	cellular	JJ
cord-301755-fxfsr9bj	41	32	receptors	receptor	NNS
cord-301755-fxfsr9bj	41	33	,	,	,
cord-301755-fxfsr9bj	41	34	and	and	CC
cord-301755-fxfsr9bj	41	35	it	-PRON-	PRP
cord-301755-fxfsr9bj	41	36	is	be	VBZ
cord-301755-fxfsr9bj	41	37	also	also	RB
cord-301755-fxfsr9bj	41	38	the	the	DT
cord-301755-fxfsr9bj	41	39	immunodominant	immunodominant	JJ
cord-301755-fxfsr9bj	41	40	component	component	NN
cord-301755-fxfsr9bj	41	41	which	which	WDT
cord-301755-fxfsr9bj	41	42	interacts	interact	VBZ
cord-301755-fxfsr9bj	41	43	with	with	IN
cord-301755-fxfsr9bj	41	44	the	the	DT
cord-301755-fxfsr9bj	41	45	host	host	NN
cord-301755-fxfsr9bj	41	46	immune	immune	JJ
cord-301755-fxfsr9bj	41	47	system	system	NN
cord-301755-fxfsr9bj	41	48	(	(	-LRB-
cord-301755-fxfsr9bj	41	49	Sturman	Sturman	NNP
cord-301755-fxfsr9bj	41	50	and	and	CC
cord-301755-fxfsr9bj	41	51	Holmes	Holmes	NNP
cord-301755-fxfsr9bj	41	52	,	,	,
cord-301755-fxfsr9bj	41	53	1983	1983	CD
cord-301755-fxfsr9bj	41	54	)	)	-RRB-
cord-301755-fxfsr9bj	41	55	.	.	.
cord-301755-fxfsr9bj	42	1	The	the	DT
cord-301755-fxfsr9bj	42	2	role	role	NN
cord-301755-fxfsr9bj	42	3	of	of	IN
cord-301755-fxfsr9bj	42	4	the	the	DT
cord-301755-fxfsr9bj	42	5	other	other	JJ
cord-301755-fxfsr9bj	42	6	structural	structural	JJ
cord-301755-fxfsr9bj	42	7	proteins	protein	NNS
cord-301755-fxfsr9bj	42	8	in	in	IN
cord-301755-fxfsr9bj	42	9	viral	viral	JJ
cord-301755-fxfsr9bj	42	10	pathogenesis	pathogenesis	NN
cord-301755-fxfsr9bj	42	11	is	be	VBZ
cord-301755-fxfsr9bj	42	12	less	less	RBR
cord-301755-fxfsr9bj	42	13	well	well	RB
cord-301755-fxfsr9bj	42	14	understood	understand	VBN
cord-301755-fxfsr9bj	42	15	;	;	:
cord-301755-fxfsr9bj	42	16	passive	passive	JJ
cord-301755-fxfsr9bj	42	17	immunization	immunization	NN
cord-301755-fxfsr9bj	42	18	with	with	IN
cord-301755-fxfsr9bj	42	19	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	42	20	specific	specific	JJ
cord-301755-fxfsr9bj	42	21	for	for	IN
cord-301755-fxfsr9bj	42	22	N	N	NNP
cord-301755-fxfsr9bj	42	23	and	and	CC
cord-301755-fxfsr9bj	42	24	M	M	NNP
cord-301755-fxfsr9bj	42	25	(	(	-LRB-
cord-301755-fxfsr9bj	42	26	membrane	membrane	NN
cord-301755-fxfsr9bj	42	27	)	)	-RRB-
cord-301755-fxfsr9bj	42	28	proteins	protein	NNS
cord-301755-fxfsr9bj	42	29	also	also	RB
cord-301755-fxfsr9bj	42	30	changed	change	VBD
cord-301755-fxfsr9bj	42	31	viral	viral	JJ
cord-301755-fxfsr9bj	42	32	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	42	33	(	(	-LRB-
cord-301755-fxfsr9bj	42	34	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	42	35	et	et	NNP
cord-301755-fxfsr9bj	42	36	a/.	a/.	NN
cord-301755-fxfsr9bj	42	37	,	,	,
cord-301755-fxfsr9bj	42	38	1989	1989	CD
cord-301755-fxfsr9bj	42	39	;	;	:
cord-301755-fxfsr9bj	43	1	Nakanaga	Nakanaga	NNP
cord-301755-fxfsr9bj	43	2	et	et	NNP
cord-301755-fxfsr9bj	43	3	a/.	a/.	NNP
cord-301755-fxfsr9bj	43	4	,	,	,
cord-301755-fxfsr9bj	43	5	1986	1986	CD
cord-301755-fxfsr9bj	43	6	)	)	-RRB-
cord-301755-fxfsr9bj	43	7	.	.	.
cord-301755-fxfsr9bj	44	1	Previously	previously	RB
cord-301755-fxfsr9bj	44	2	,	,	,
cord-301755-fxfsr9bj	44	3	we	-PRON-	PRP
cord-301755-fxfsr9bj	44	4	have	have	VBP
cord-301755-fxfsr9bj	44	5	isolated	isolate	VBN
cord-301755-fxfsr9bj	44	6	several	several	JJ
cord-301755-fxfsr9bj	44	7	neutralizationresistant	neutralizationresistant	JJ
cord-301755-fxfsr9bj	44	8	variants	variant	NNS
cord-301755-fxfsr9bj	44	9	of	of	IN
cord-301755-fxfsr9bj	44	10	JHM	JHM	NNP
cord-301755-fxfsr9bj	44	11	using	use	VBG
cord-301755-fxfsr9bj	44	12	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	44	13	specific	specific	JJ
cord-301755-fxfsr9bj	44	14	for	for	IN
cord-301755-fxfsr9bj	44	15	the	the	DT
cord-301755-fxfsr9bj	44	16	S	S	NNP
cord-301755-fxfsr9bj	44	17	protein	protein	NN
cord-301755-fxfsr9bj	44	18	(	(	-LRB-
cord-301755-fxfsr9bj	44	19	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	44	20	et	et	NNP
cord-301755-fxfsr9bj	44	21	a/.	a/.	NN
cord-301755-fxfsr9bj	44	22	,	,	,
cord-301755-fxfsr9bj	44	23	1983	1983	CD
cord-301755-fxfsr9bj	44	24	)	)	-RRB-
cord-301755-fxfsr9bj	44	25	.	.	.
cord-301755-fxfsr9bj	45	1	These	these	DT
cord-301755-fxfsr9bj	45	2	variants	variant	NNS
cord-301755-fxfsr9bj	45	3	showed	show	VBD
cord-301755-fxfsr9bj	45	4	strikingly	strikingly	RB
cord-301755-fxfsr9bj	45	5	different	different	JJ
cord-301755-fxfsr9bj	45	6	capabilities	capability	NNS
cord-301755-fxfsr9bj	45	7	from	from	IN
cord-301755-fxfsr9bj	45	8	that	that	DT
cord-301755-fxfsr9bj	45	9	of	of	IN
cord-301755-fxfsr9bj	45	10	the	the	DT
cord-301755-fxfsr9bj	45	11	parental	parental	JJ
cord-301755-fxfsr9bj	45	12	JHM	JHM	NNP
cord-301755-fxfsr9bj	45	13	virus	virus	NN
cord-301755-fxfsr9bj	45	14	in	in	IN
cord-301755-fxfsr9bj	45	15	causing	cause	VBG
cord-301755-fxfsr9bj	45	16	demyelination	demyelination	NN
cord-301755-fxfsr9bj	45	17	or	or	CC
cord-301755-fxfsr9bj	45	18	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	45	19	in	in	IN
cord-301755-fxfsr9bj	45	20	rodents	rodent	NNS
cord-301755-fxfsr9bj	45	21	(	(	-LRB-
cord-301755-fxfsr9bj	45	22	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	45	23	eta/.	eta/.	CD
cord-301755-fxfsr9bj	45	24	,	,	,
cord-301755-fxfsr9bj	46	1	1986	1986	CD
cord-301755-fxfsr9bj	46	2	(	(	-LRB-
cord-301755-fxfsr9bj	46	3	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	46	4	eta/.	eta/.	NNP
cord-301755-fxfsr9bj	46	5	,	,	,
cord-301755-fxfsr9bj	46	6	,	,	,
cord-301755-fxfsr9bj	46	7	1987	1987	CD
cord-301755-fxfsr9bj	46	8	.	.	.
cord-301755-fxfsr9bj	47	1	While	while	IN
cord-301755-fxfsr9bj	47	2	the	the	DT
cord-301755-fxfsr9bj	47	3	parental	parental	JJ
cord-301755-fxfsr9bj	47	4	virus	virus	NN
cord-301755-fxfsr9bj	47	5	caused	cause	VBD
cord-301755-fxfsr9bj	47	6	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	47	7	,	,	,
cord-301755-fxfsr9bj	47	8	the	the	DT
cord-301755-fxfsr9bj	47	9	variants	variant	NNS
cord-301755-fxfsr9bj	47	10	selected	select	VBN
cord-301755-fxfsr9bj	47	11	with	with	IN
cord-301755-fxfsr9bj	47	12	one	one	CD
cord-301755-fxfsr9bj	47	13	neutralizing	neutralize	VBG
cord-301755-fxfsr9bj	47	14	MAb	MAb	NNS
cord-301755-fxfsr9bj	47	15	(	(	-LRB-
cord-301755-fxfsr9bj	47	16	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	47	17	)	)	-RRB-
cord-301755-fxfsr9bj	47	18	had	have	VBD
cord-301755-fxfsr9bj	47	19	lower	low	JJR
cord-301755-fxfsr9bj	47	20	virulence	virulence	NN
cord-301755-fxfsr9bj	47	21	and	and	CC
cord-301755-fxfsr9bj	47	22	caused	cause	VBN
cord-301755-fxfsr9bj	47	23	demyelination	demyelination	NN
cord-301755-fxfsr9bj	47	24	,	,	,
cord-301755-fxfsr9bj	47	25	and	and	CC
cord-301755-fxfsr9bj	47	26	the	the	DT
cord-301755-fxfsr9bj	47	27	variants	variant	NNS
cord-301755-fxfsr9bj	47	28	selected	select	VBN
cord-301755-fxfsr9bj	47	29	with	with	IN
cord-301755-fxfsr9bj	47	30	two	two	CD
cord-301755-fxfsr9bj	47	31	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	47	32	(	(	-LRB-
cord-301755-fxfsr9bj	47	33	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	47	34	and	and	CC
cord-301755-fxfsr9bj	47	35	1.7.2	1.7.2	NNP
cord-301755-fxfsr9bj	47	36	)	)	-RRB-
cord-301755-fxfsr9bj	47	37	caused	cause	VBD
cord-301755-fxfsr9bj	47	38	neither	neither	CC
cord-301755-fxfsr9bj	47	39	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	47	40	nor	nor	CC
cord-301755-fxfsr9bj	47	41	demyelination	demyelination	NN
cord-301755-fxfsr9bj	47	42	(	(	-LRB-
cord-301755-fxfsr9bj	47	43	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	47	44	et	et	NNP
cord-301755-fxfsr9bj	47	45	al	al	NNP
cord-301755-fxfsr9bj	47	46	.	.	NNP
cord-301755-fxfsr9bj	47	47	,	,	,
cord-301755-fxfsr9bj	47	48	1986	1986	CD
cord-301755-fxfsr9bj	48	1	(	(	-LRB-
cord-301755-fxfsr9bj	48	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	48	3	et	et	NNP
cord-301755-fxfsr9bj	48	4	al	al	NNP
cord-301755-fxfsr9bj	48	5	.	.	NNP
cord-301755-fxfsr9bj	48	6	,	,	,
cord-301755-fxfsr9bj	48	7	,	,	,
cord-301755-fxfsr9bj	48	8	1987	1987	CD
cord-301755-fxfsr9bj	48	9	.	.	.
cord-301755-fxfsr9bj	49	1	Based	base	VBN
cord-301755-fxfsr9bj	49	2	on	on	IN
cord-301755-fxfsr9bj	49	3	these	these	DT
cord-301755-fxfsr9bj	49	4	studies	study	NNS
cord-301755-fxfsr9bj	49	5	,	,	,
cord-301755-fxfsr9bj	49	6	we	-PRON-	PRP
cord-301755-fxfsr9bj	49	7	hypothesized	hypothesize	VBD
cord-301755-fxfsr9bj	49	8	that	that	IN
cord-301755-fxfsr9bj	49	9	MAb	MAb	NNPS
cord-301755-fxfsr9bj	49	10	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	49	11	identified	identify	VBD
cord-301755-fxfsr9bj	49	12	a	a	DT
cord-301755-fxfsr9bj	49	13	specific	specific	JJ
cord-301755-fxfsr9bj	49	14	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	49	15	-	-	HYPH
cord-301755-fxfsr9bj	49	16	determining	determine	VBG
cord-301755-fxfsr9bj	49	17	site	site	NN
cord-301755-fxfsr9bj	49	18	and	and	CC
cord-301755-fxfsr9bj	49	19	MAb	MAb	NNPS
cord-301755-fxfsr9bj	49	20	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	49	21	identified	identify	VBD
cord-301755-fxfsr9bj	49	22	a	a	DT
cord-301755-fxfsr9bj	49	23	specificdemyelination	specificdemyelination	NN
cord-301755-fxfsr9bj	49	24	-	-	HYPH
cord-301755-fxfsr9bj	49	25	determining	determine	VBG
cord-301755-fxfsr9bj	49	26	site	site	NN
cord-301755-fxfsr9bj	49	27	on	on	IN
cord-301755-fxfsr9bj	49	28	the	the	DT
cord-301755-fxfsr9bj	49	29	S	S	NNP
cord-301755-fxfsr9bj	49	30	protein	protein	NN
cord-301755-fxfsr9bj	49	31	.	.	.
cord-301755-fxfsr9bj	50	1	Alternatively	alternatively	RB
cord-301755-fxfsr9bj	50	2	,	,	,
cord-301755-fxfsr9bj	50	3	we	-PRON-	PRP
cord-301755-fxfsr9bj	50	4	considered	consider	VBD
cord-301755-fxfsr9bj	50	5	the	the	DT
cord-301755-fxfsr9bj	50	6	possibility	possibility	NN
cord-301755-fxfsr9bj	50	7	that	that	IN
cord-301755-fxfsr9bj	50	8	a	a	DT
cord-301755-fxfsr9bj	50	9	single	single	JJ
cord-301755-fxfsr9bj	50	10	linear	linear	JJ
cord-301755-fxfsr9bj	50	11	determinant	determinant	NN
cord-301755-fxfsr9bj	50	12	might	may	MD
cord-301755-fxfsr9bj	50	13	not	not	RB
cord-301755-fxfsr9bj	50	14	be	be	VB
cord-301755-fxfsr9bj	50	15	the	the	DT
cord-301755-fxfsr9bj	50	16	necessary	necessary	JJ
cord-301755-fxfsr9bj	50	17	and	and	CC
cord-301755-fxfsr9bj	50	18	sufficient	sufficient	JJ
cord-301755-fxfsr9bj	50	19	cause	cause	NN
cord-301755-fxfsr9bj	50	20	of	of	IN
cord-301755-fxfsr9bj	50	21	JHM	JHM	NNP
cord-301755-fxfsr9bj	50	22	-	-	HYPH
cord-301755-fxfsr9bj	50	23	induced	induce	VBN
cord-301755-fxfsr9bj	50	24	demyelination	demyelination	NN
cord-301755-fxfsr9bj	50	25	,	,	,
cord-301755-fxfsr9bj	50	26	and	and	CC
cord-301755-fxfsr9bj	50	27	that	that	IN
cord-301755-fxfsr9bj	50	28	demyelination	demyelination	NN
cord-301755-fxfsr9bj	50	29	would	would	MD
cord-301755-fxfsr9bj	50	30	depend	depend	VB
cord-301755-fxfsr9bj	50	31	on	on	IN
cord-301755-fxfsr9bj	50	32	several	several	JJ
cord-301755-fxfsr9bj	50	33	regions	region	NNS
cord-301755-fxfsr9bj	50	34	of	of	IN
cord-301755-fxfsr9bj	50	35	S	S	NNP
cord-301755-fxfsr9bj	50	36	or	or	CC
cord-301755-fxfsr9bj	50	37	even	even	RB
cord-301755-fxfsr9bj	50	38	on	on	IN
cord-301755-fxfsr9bj	50	39	other	other	JJ
cord-301755-fxfsr9bj	50	40	viral	viral	JJ
cord-301755-fxfsr9bj	50	41	genes	gene	NNS
cord-301755-fxfsr9bj	50	42	(	(	-LRB-
cord-301755-fxfsr9bj	50	43	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	50	44	et	et	NNP
cord-301755-fxfsr9bj	50	45	a/.	a/.	NNP
cord-301755-fxfsr9bj	50	46	,	,	,
cord-301755-fxfsr9bj	50	47	1987	1987	CD
cord-301755-fxfsr9bj	50	48	)	)	-RRB-
cord-301755-fxfsr9bj	50	49	.	.	.
cord-301755-fxfsr9bj	51	1	Our	-PRON-	PRP$
cord-301755-fxfsr9bj	51	2	present	present	JJ
cord-301755-fxfsr9bj	51	3	sequence	sequence	NN
cord-301755-fxfsr9bj	51	4	analysis	analysis	NN
cord-301755-fxfsr9bj	51	5	indicates	indicate	VBZ
cord-301755-fxfsr9bj	51	6	that	that	IN
cord-301755-fxfsr9bj	51	7	the	the	DT
cord-301755-fxfsr9bj	51	8	latter	latter	JJ
cord-301755-fxfsr9bj	51	9	hypothesis	hypothesis	NN
cord-301755-fxfsr9bj	51	10	is	be	VBZ
cord-301755-fxfsr9bj	51	11	correct	correct	JJ
cord-301755-fxfsr9bj	51	12	;	;	:
cord-301755-fxfsr9bj	51	13	that	that	RB
cord-301755-fxfsr9bj	51	14	is	is	RB
cord-301755-fxfsr9bj	51	15	,	,	,
cord-301755-fxfsr9bj	51	16	the	the	DT
cord-301755-fxfsr9bj	51	17	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	51	18	of	of	IN
cord-301755-fxfsr9bj	51	19	JHM	JHM	NNP
cord-301755-fxfsr9bj	51	20	depends	depend	VBZ
cord-301755-fxfsr9bj	51	21	on	on	IN
cord-301755-fxfsr9bj	51	22	the	the	DT
cord-301755-fxfsr9bj	51	23	characteristics	characteristic	NNS
cord-301755-fxfsr9bj	51	24	of	of	IN
cord-301755-fxfsr9bj	51	25	at	at	RB
cord-301755-fxfsr9bj	51	26	least	least	RBS
cord-301755-fxfsr9bj	51	27	two	two	CD
cord-301755-fxfsr9bj	51	28	sites	site	NNS
cord-301755-fxfsr9bj	51	29	on	on	IN
cord-301755-fxfsr9bj	51	30	the	the	DT
cord-301755-fxfsr9bj	51	31	S	S	NNP
cord-301755-fxfsr9bj	51	32	gene	gene	NN
cord-301755-fxfsr9bj	51	33	.	.	.
cord-301755-fxfsr9bj	52	1	Complex	complex	JJ
cord-301755-fxfsr9bj	52	2	interaction	interaction	NN
cord-301755-fxfsr9bj	52	3	of	of	IN
cord-301755-fxfsr9bj	52	4	different	different	JJ
cord-301755-fxfsr9bj	52	5	regions	region	NNS
cord-301755-fxfsr9bj	52	6	of	of	IN
cord-301755-fxfsr9bj	52	7	S	S	NNP
cord-301755-fxfsr9bj	52	8	protein	protein	NN
cord-301755-fxfsr9bj	52	9	likely	likely	JJ
cord-301755-fxfsr9bj	52	10	influences	influence	VBZ
cord-301755-fxfsr9bj	52	11	viral	viral	JJ
cord-301755-fxfsr9bj	52	12	pathogenesis	pathogenesis	NN
cord-301755-fxfsr9bj	52	13	by	by	IN
cord-301755-fxfsr9bj	52	14	changing	change	VBG
cord-301755-fxfsr9bj	52	15	the	the	DT
cord-301755-fxfsr9bj	52	16	degree	degree	NN
cord-301755-fxfsr9bj	52	17	of	of	IN
cord-301755-fxfsr9bj	52	18	viral	viral	JJ
cord-301755-fxfsr9bj	52	19	attenuation	attenuation	NN
cord-301755-fxfsr9bj	52	20	in	in	IN
cord-301755-fxfsr9bj	52	21	viva	viva	NNP
cord-301755-fxfsr9bj	52	22	.	.	.
cord-301755-fxfsr9bj	53	1	The	the	DT
cord-301755-fxfsr9bj	53	2	viruses	virus	NNS
cord-301755-fxfsr9bj	53	3	used	use	VBN
cord-301755-fxfsr9bj	53	4	in	in	IN
cord-301755-fxfsr9bj	53	5	this	this	DT
cord-301755-fxfsr9bj	53	6	study	study	NN
cord-301755-fxfsr9bj	53	7	included	include	VBD
cord-301755-fxfsr9bj	53	8	several	several	JJ
cord-301755-fxfsr9bj	53	9	JHM	JHM	NNP
cord-301755-fxfsr9bj	53	10	variants	variant	NNS
cord-301755-fxfsr9bj	53	11	which	which	WDT
cord-301755-fxfsr9bj	53	12	were	be	VBD
cord-301755-fxfsr9bj	53	13	selected	select	VBN
cord-301755-fxfsr9bj	53	14	for	for	IN
cord-301755-fxfsr9bj	53	15	their	-PRON-	PRP$
cord-301755-fxfsr9bj	53	16	resistance	resistance	NN
cord-301755-fxfsr9bj	53	17	to	to	IN
cord-301755-fxfsr9bj	53	18	neutralizing	neutralize	VBG
cord-301755-fxfsr9bj	53	19	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	53	20	specific	specific	JJ
cord-301755-fxfsr9bj	53	21	for	for	IN
cord-301755-fxfsr9bj	53	22	the	the	DT
cord-301755-fxfsr9bj	53	23	S	S	NNP
cord-301755-fxfsr9bj	53	24	protein	protein	NN
cord-301755-fxfsr9bj	53	25	(	(	-LRB-
cord-301755-fxfsr9bj	53	26	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	53	27	et	et	NNP
cord-301755-fxfsr9bj	53	28	a/.	a/.	NN
cord-301755-fxfsr9bj	53	29	,	,	,
cord-301755-fxfsr9bj	53	30	1983	1983	CD
cord-301755-fxfsr9bj	53	31	)	)	-RRB-
cord-301755-fxfsr9bj	53	32	.	.	.
cord-301755-fxfsr9bj	54	1	Their	-PRON-	PRP$
cord-301755-fxfsr9bj	54	2	virulence	virulence	NN
cord-301755-fxfsr9bj	54	3	and	and	CC
cord-301755-fxfsr9bj	54	4	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	54	5	in	in	IN
cord-301755-fxfsr9bj	54	6	mice	mouse	NNS
cord-301755-fxfsr9bj	54	7	are	be	VBP
cord-301755-fxfsr9bj	54	8	listed	list	VBN
cord-301755-fxfsr9bj	54	9	in	in	IN
cord-301755-fxfsr9bj	54	10	Table	Table	NNP
cord-301755-fxfsr9bj	54	11	1	1	CD
cord-301755-fxfsr9bj	54	12	.	.	.
cord-301755-fxfsr9bj	55	1	The	the	DT
cord-301755-fxfsr9bj	55	2	parental	parental	JJ
cord-301755-fxfsr9bj	55	3	virus	virus	NN
cord-301755-fxfsr9bj	55	4	JHM	JHM	NNP
cord-301755-fxfsr9bj	55	5	-	-	HYPH
cord-301755-fxfsr9bj	55	6	DL	DL	NNP
cord-301755-fxfsr9bj	55	7	was	be	VBD
cord-301755-fxfsr9bj	55	8	a	a	DT
cord-301755-fxfsr9bj	55	9	large	large	JJ
cord-301755-fxfsr9bj	55	10	-	-	HYPH
cord-301755-fxfsr9bj	55	11	plaque	plaque	NN
cord-301755-fxfsr9bj	55	12	isolate	isolate	NN
cord-301755-fxfsr9bj	55	13	of	of	IN
cord-301755-fxfsr9bj	55	14	wild	wild	JJ
cord-301755-fxfsr9bj	55	15	-	-	HYPH
cord-301755-fxfsr9bj	55	16	type	type	NN
cord-301755-fxfsr9bj	55	17	JHM	JHM	NNP
cord-301755-fxfsr9bj	55	18	strain	strain	NN
cord-301755-fxfsr9bj	55	19	and	and	CC
cord-301755-fxfsr9bj	55	20	caused	cause	VBD
cord-301755-fxfsr9bj	55	21	marked	mark	VBN
cord-301755-fxfsr9bj	55	22	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	55	23	with	with	IN
cord-301755-fxfsr9bj	55	24	chronic	chronic	JJ
cord-301755-fxfsr9bj	55	25	demyelination	demyelination	NN
cord-301755-fxfsr9bj	55	26	in	in	IN
cord-301755-fxfsr9bj	55	27	survivors	survivor	NNS
cord-301755-fxfsr9bj	55	28	(	(	-LRB-
cord-301755-fxfsr9bj	55	29	Stohlman	Stohlman	NNP
cord-301755-fxfsr9bj	55	30	et	et	NNP
cord-301755-fxfsr9bj	55	31	al	al	NNP
cord-301755-fxfsr9bj	55	32	.	.	NNP
cord-301755-fxfsr9bj	55	33	,	,	,
cord-301755-fxfsr9bj	55	34	1982	1982	CD
cord-301755-fxfsr9bj	55	35	)	)	-RRB-
cord-301755-fxfsr9bj	55	36	.	.	.
cord-301755-fxfsr9bj	56	1	The	the	DT
cord-301755-fxfsr9bj	56	2	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	56	3	-	-	HYPH
cord-301755-fxfsr9bj	56	4	l	l	NN
cord-301755-fxfsr9bj	56	5	Note	note	NN
cord-301755-fxfsr9bj	56	6	.	.	.
cord-301755-fxfsr9bj	57	1	MAb	MAb	NNS
cord-301755-fxfsr9bj	57	2	,	,	,
cord-301755-fxfsr9bj	57	3	Monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	57	4	antibody	antibody	NN
cord-301755-fxfsr9bj	57	5	;	;	:
cord-301755-fxfsr9bj	57	6	LD	LD	NNP
cord-301755-fxfsr9bj	57	7	,	,	,
cord-301755-fxfsr9bj	57	8	,	,	,
cord-301755-fxfsr9bj	57	9	,	,	,
cord-301755-fxfsr9bj	57	10	50	50	CD
cord-301755-fxfsr9bj	57	11	%	%	NN
cord-301755-fxfsr9bj	57	12	lethal	lethal	JJ
cord-301755-fxfsr9bj	57	13	dose	dose	NN
cord-301755-fxfsr9bj	57	14	in	in	IN
cord-301755-fxfsr9bj	57	15	C57/	c57/	NN
cord-301755-fxfsr9bj	57	16	B6	b6	NN
cord-301755-fxfsr9bj	57	17	mice	mouse	NNS
cord-301755-fxfsr9bj	57	18	on	on	IN
cord-301755-fxfsr9bj	57	19	day	day	NN
cord-301755-fxfsr9bj	57	20	7	7	CD
cord-301755-fxfsr9bj	57	21	after	after	IN
cord-301755-fxfsr9bj	57	22	intracerebral	intracerebral	JJ
cord-301755-fxfsr9bj	57	23	inoculation	inoculation	NN
cord-301755-fxfsr9bj	57	24	;	;	:
cord-301755-fxfsr9bj	58	1	PFU	pfu	NN
cord-301755-fxfsr9bj	58	2	,	,	,
cord-301755-fxfsr9bj	58	3	plaque	plaque	NN
cord-301755-fxfsr9bj	58	4	forming	form	VBG
cord-301755-fxfsr9bj	58	5	units	unit	NNS
cord-301755-fxfsr9bj	58	6	;	;	:
cord-301755-fxfsr9bj	58	7	E	e	UH
cord-301755-fxfsr9bj	58	8	,	,	,
cord-301755-fxfsr9bj	58	9	predominantly	predominantly	RB
cord-301755-fxfsr9bj	58	10	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	58	11	;	;	:
cord-301755-fxfsr9bj	58	12	D.	D.	NNP
cord-301755-fxfsr9bj	58	13	predominantly	predominantly	RB
cord-301755-fxfsr9bj	58	14	demyelination	demyelination	NN
cord-301755-fxfsr9bj	58	15	.	.	.
cord-301755-fxfsr9bj	59	1	(	(	-LRB-
cord-301755-fxfsr9bj	59	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	59	3	et	et	NNP
cord-301755-fxfsr9bj	59	4	al	al	NNP
cord-301755-fxfsr9bj	59	5	.	.	NNP
cord-301755-fxfsr9bj	59	6	,	,	,
cord-301755-fxfsr9bj	59	7	1986	1986	CD
cord-301755-fxfsr9bj	60	1	(	(	-LRB-
cord-301755-fxfsr9bj	60	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	60	3	et	et	NNP
cord-301755-fxfsr9bj	60	4	al	al	NNP
cord-301755-fxfsr9bj	60	5	.	.	NNP
cord-301755-fxfsr9bj	60	6	,	,	,
cord-301755-fxfsr9bj	60	7	,	,	,
cord-301755-fxfsr9bj	60	8	1987	1987	CD
cord-301755-fxfsr9bj	60	9	.	.	.
cord-301755-fxfsr9bj	61	1	variant	variant	NN
cord-301755-fxfsr9bj	61	2	was	be	VBD
cord-301755-fxfsr9bj	61	3	selected	select	VBN
cord-301755-fxfsr9bj	61	4	from	from	IN
cord-301755-fxfsr9bj	61	5	JHM	JHM	NNP
cord-301755-fxfsr9bj	61	6	-	-	HYPH
cord-301755-fxfsr9bj	61	7	DLwith	DLwith	NNP
cord-301755-fxfsr9bj	61	8	MAb	MAb	NNPS
cord-301755-fxfsr9bj	61	9	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	61	10	,	,	,
cord-301755-fxfsr9bj	61	11	and	and	CC
cord-301755-fxfsr9bj	61	12	caused	cause	VBD
cord-301755-fxfsr9bj	61	13	marked	mark	VBN
cord-301755-fxfsr9bj	61	14	demyelination	demyelination	NN
cord-301755-fxfsr9bj	61	15	with	with	IN
cord-301755-fxfsr9bj	61	16	little	little	JJ
cord-301755-fxfsr9bj	61	17	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	61	18	(	(	-LRB-
cord-301755-fxfsr9bj	61	19	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	61	20	et	et	NNP
cord-301755-fxfsr9bj	61	21	al	al	NNP
cord-301755-fxfsr9bj	61	22	.	.	NNP
cord-301755-fxfsr9bj	61	23	,	,	,
cord-301755-fxfsr9bj	61	24	1986	1986	CD
cord-301755-fxfsr9bj	61	25	)	)	-RRB-
cord-301755-fxfsr9bj	61	26	.	.	.
cord-301755-fxfsr9bj	62	1	The	the	DT
cord-301755-fxfsr9bj	62	2	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	62	3	variant	variant	NN
cord-301755-fxfsr9bj	62	4	was	be	VBD
cord-301755-fxfsr9bj	62	5	selected	select	VBN
cord-301755-fxfsr9bj	62	6	from	from	IN
cord-301755-fxfsr9bj	62	7	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	62	8	-	-	HYPH
cord-301755-fxfsr9bj	62	9	l	l	NN
cord-301755-fxfsr9bj	62	10	with	with	IN
cord-301755-fxfsr9bj	62	11	another	another	DT
cord-301755-fxfsr9bj	62	12	MAb	MAb	NNPS
cord-301755-fxfsr9bj	62	13	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	62	14	and	and	CC
cord-301755-fxfsr9bj	62	15	was	be	VBD
cord-301755-fxfsr9bj	62	16	nonpathogenic	nonpathogenic	JJ
cord-301755-fxfsr9bj	62	17	,	,	,
cord-301755-fxfsr9bj	62	18	causing	cause	VBG
cord-301755-fxfsr9bj	62	19	only	only	RB
cord-301755-fxfsr9bj	62	20	minimal	minimal	JJ
cord-301755-fxfsr9bj	62	21	neuropathology	neuropathology	NN
cord-301755-fxfsr9bj	62	22	(	(	-LRB-
cord-301755-fxfsr9bj	62	23	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	62	24	eta/.	eta/.	CD
cord-301755-fxfsr9bj	62	25	,	,	,
cord-301755-fxfsr9bj	62	26	1987	1987	CD
cord-301755-fxfsr9bj	62	27	)	)	-RRB-
cord-301755-fxfsr9bj	62	28	.	.	.
cord-301755-fxfsr9bj	63	1	The	the	DT
cord-301755-fxfsr9bj	63	2	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	63	3	-	-	HYPH
cord-301755-fxfsr9bj	63	4	l	l	NN
cord-301755-fxfsr9bj	63	5	variant	variant	NN
cord-301755-fxfsr9bj	63	6	was	be	VBD
cord-301755-fxfsr9bj	63	7	selected	select	VBN
cord-301755-fxfsr9bj	63	8	directly	directly	RB
cord-301755-fxfsr9bj	63	9	from	from	IN
cord-301755-fxfsr9bj	63	10	JHM	JHM	NNP
cord-301755-fxfsr9bj	63	11	-	-	HYPH
cord-301755-fxfsr9bj	63	12	DL	DL	NNP
cord-301755-fxfsr9bj	63	13	with	with	IN
cord-301755-fxfsr9bj	63	14	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	63	15	and	and	CC
cord-301755-fxfsr9bj	63	16	remained	remain	VBD
cord-301755-fxfsr9bj	63	17	encephalitic	encephalitic	JJ
cord-301755-fxfsr9bj	63	18	(	(	-LRB-
cord-301755-fxfsr9bj	63	19	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	63	20	et	et	NNP
cord-301755-fxfsr9bj	63	21	a/.	a/.	NNP
cord-301755-fxfsr9bj	63	22	,	,	,
cord-301755-fxfsr9bj	63	23	1986	1986	CD
cord-301755-fxfsr9bj	63	24	)	)	-RRB-
cord-301755-fxfsr9bj	63	25	.	.	.
cord-301755-fxfsr9bj	64	1	An	an	DT
cord-301755-fxfsr9bj	64	2	astrocytoma	astrocytoma	NN
cord-301755-fxfsr9bj	64	3	cell	cell	NN
cord-301755-fxfsr9bj	64	4	line	line	NN
cord-301755-fxfsr9bj	64	5	(	(	-LRB-
cord-301755-fxfsr9bj	64	6	DBT	DBT	NNP
cord-301755-fxfsr9bj	64	7	cell	cell	NN
cord-301755-fxfsr9bj	64	8	)	)	-RRB-
cord-301755-fxfsr9bj	64	9	derived	derive	VBN
cord-301755-fxfsr9bj	64	10	from	from	IN
cord-301755-fxfsr9bj	64	11	mice	mouse	NNS
cord-301755-fxfsr9bj	64	12	(	(	-LRB-
cord-301755-fxfsr9bj	64	13	Hirano	Hirano	NNP
cord-301755-fxfsr9bj	64	14	et	et	NNP
cord-301755-fxfsr9bj	64	15	a/.	a/.	NN
cord-301755-fxfsr9bj	64	16	,	,	,
cord-301755-fxfsr9bj	64	17	1974	1974	CD
cord-301755-fxfsr9bj	64	18	)	)	-RRB-
cord-301755-fxfsr9bj	64	19	was	be	VBD
cord-301755-fxfsr9bj	64	20	used	use	VBN
cord-301755-fxfsr9bj	64	21	throughout	throughout	IN
cord-301755-fxfsr9bj	64	22	the	the	DT
cord-301755-fxfsr9bj	64	23	experiment	experiment	NN
cord-301755-fxfsr9bj	64	24	.	.	.
cord-301755-fxfsr9bj	65	1	All	all	DT
cord-301755-fxfsr9bj	65	2	of	of	IN
cord-301755-fxfsr9bj	65	3	these	these	DT
cord-301755-fxfsr9bj	65	4	viruses	virus	NNS
cord-301755-fxfsr9bj	65	5	were	be	VBD
cord-301755-fxfsr9bj	65	6	initially	initially	RB
cord-301755-fxfsr9bj	65	7	plaque	plaque	NN
cord-301755-fxfsr9bj	65	8	-	-	HYPH
cord-301755-fxfsr9bj	65	9	purified	purify	VBN
cord-301755-fxfsr9bj	65	10	three	three	CD
cord-301755-fxfsr9bj	65	11	times	time	NNS
cord-301755-fxfsr9bj	65	12	before	before	IN
cord-301755-fxfsr9bj	65	13	propagation	propagation	NN
cord-301755-fxfsr9bj	65	14	as	as	IN
cord-301755-fxfsr9bj	65	15	virus	virus	NN
cord-301755-fxfsr9bj	65	16	stock	stock	NN
cord-301755-fxfsr9bj	65	17	.	.	.
cord-301755-fxfsr9bj	66	1	Early	early	JJ
cord-301755-fxfsr9bj	66	2	passage	passage	NN
cord-301755-fxfsr9bj	66	3	viruses	virus	NNS
cord-301755-fxfsr9bj	66	4	(	(	-LRB-
cord-301755-fxfsr9bj	66	5	before	before	IN
cord-301755-fxfsr9bj	66	6	passage	passage	NN
cord-301755-fxfsr9bj	66	7	3	3	CD
cord-301755-fxfsr9bj	66	8	)	)	-RRB-
cord-301755-fxfsr9bj	66	9	were	be	VBD
cord-301755-fxfsr9bj	66	10	used	use	VBN
cord-301755-fxfsr9bj	66	11	for	for	IN
cord-301755-fxfsr9bj	66	12	preparing	prepare	VBG
cord-301755-fxfsr9bj	66	13	large	large	JJ
cord-301755-fxfsr9bj	66	14	amounts	amount	NNS
cord-301755-fxfsr9bj	66	15	of	of	IN
cord-301755-fxfsr9bj	66	16	virus	virus	NN
cord-301755-fxfsr9bj	66	17	for	for	IN
cord-301755-fxfsr9bj	66	18	biochemical	biochemical	JJ
cord-301755-fxfsr9bj	66	19	studies	study	NNS
cord-301755-fxfsr9bj	66	20	.	.	.
cord-301755-fxfsr9bj	67	1	The	the	DT
cord-301755-fxfsr9bj	67	2	viruses	virus	NNS
cord-301755-fxfsr9bj	67	3	of	of	IN
cord-301755-fxfsr9bj	67	4	the	the	DT
cord-301755-fxfsr9bj	67	5	same	same	JJ
cord-301755-fxfsr9bj	67	6	passage	passage	NN
cord-301755-fxfsr9bj	67	7	level	level	NN
cord-301755-fxfsr9bj	67	8	were	be	VBD
cord-301755-fxfsr9bj	67	9	previously	previously	RB
cord-301755-fxfsr9bj	67	10	used	use	VBN
cord-301755-fxfsr9bj	67	11	for	for	IN
cord-301755-fxfsr9bj	67	12	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	67	13	studies	study	NNS
cord-301755-fxfsr9bj	67	14	(	(	-LRB-
cord-301755-fxfsr9bj	67	15	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	67	16	et	et	NNP
cord-301755-fxfsr9bj	67	17	a/.	a/.	NNP
cord-301755-fxfsr9bj	67	18	,	,	,
cord-301755-fxfsr9bj	67	19	1986	1986	CD
cord-301755-fxfsr9bj	67	20	(	(	-LRB-
cord-301755-fxfsr9bj	67	21	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	67	22	et	et	NNP
cord-301755-fxfsr9bj	67	23	a/.	a/.	NNP
cord-301755-fxfsr9bj	67	24	,	,	,
cord-301755-fxfsr9bj	67	25	,	,	,
cord-301755-fxfsr9bj	67	26	1987	1987	CD
cord-301755-fxfsr9bj	67	27	.	.	.
cord-301755-fxfsr9bj	68	1	Variant	variant	NN
cord-301755-fxfsr9bj	68	2	viruses	virus	NNS
cord-301755-fxfsr9bj	68	3	were	be	VBD
cord-301755-fxfsr9bj	68	4	grown	grow	VBN
cord-301755-fxfsr9bj	68	5	in	in	IN
cord-301755-fxfsr9bj	68	6	the	the	DT
cord-301755-fxfsr9bj	68	7	presence	presence	NN
cord-301755-fxfsr9bj	68	8	of	of	IN
cord-301755-fxfsr9bj	68	9	the	the	DT
cord-301755-fxfsr9bj	68	10	respective	respective	JJ
cord-301755-fxfsr9bj	68	11	MAb	MAb	NNS
cord-301755-fxfsr9bj	68	12	used	use	VBN
cord-301755-fxfsr9bj	68	13	for	for	IN
cord-301755-fxfsr9bj	68	14	their	-PRON-	PRP$
cord-301755-fxfsr9bj	68	15	selection	selection	NN
cord-301755-fxfsr9bj	68	16	.	.	.
cord-301755-fxfsr9bj	69	1	Viruses	virus	NNS
cord-301755-fxfsr9bj	69	2	were	be	VBD
cord-301755-fxfsr9bj	69	3	mixed	mix	VBN
cord-301755-fxfsr9bj	69	4	with	with	IN
cord-301755-fxfsr9bj	69	5	an	an	DT
cord-301755-fxfsr9bj	69	6	equal	equal	JJ
cord-301755-fxfsr9bj	69	7	amount	amount	NN
cord-301755-fxfsr9bj	69	8	of	of	IN
cord-301755-fxfsr9bj	69	9	MAb	MAb	NNS
cord-301755-fxfsr9bj	69	10	tissue	tissue	NN
cord-301755-fxfsr9bj	69	11	culture	culture	NN
cord-301755-fxfsr9bj	69	12	supernatants	supernatant	NNS
cord-301755-fxfsr9bj	69	13	and	and	CC
cord-301755-fxfsr9bj	69	14	incubated	incubate	VBN
cord-301755-fxfsr9bj	69	15	for	for	IN
cord-301755-fxfsr9bj	69	16	45	45	CD
cord-301755-fxfsr9bj	69	17	to	to	TO
cord-301755-fxfsr9bj	69	18	60	60	CD
cord-301755-fxfsr9bj	69	19	min	min	NN
cord-301755-fxfsr9bj	69	20	at	at	IN
cord-301755-fxfsr9bj	69	21	37	37	CD
cord-301755-fxfsr9bj	69	22	"	"	``
cord-301755-fxfsr9bj	69	23	before	before	IN
cord-301755-fxfsr9bj	69	24	inoculating	inoculate	VBG
cord-301755-fxfsr9bj	69	25	onto	onto	IN
cord-301755-fxfsr9bj	69	26	confluent	confluent	JJ
cord-301755-fxfsr9bj	69	27	DBT	dbt	NN
cord-301755-fxfsr9bj	69	28	cell	cell	NN
cord-301755-fxfsr9bj	69	29	monolayer	monolayer	NN
cord-301755-fxfsr9bj	69	30	.	.	.
cord-301755-fxfsr9bj	70	1	After	after	IN
cord-301755-fxfsr9bj	70	2	virus	virus	NN
cord-301755-fxfsr9bj	70	3	adsorption	adsorption	NN
cord-301755-fxfsr9bj	70	4	for	for	IN
cord-301755-fxfsr9bj	70	5	1	1	CD
cord-301755-fxfsr9bj	70	6	hr	hr	NN
cord-301755-fxfsr9bj	70	7	at	at	IN
cord-301755-fxfsr9bj	70	8	37	37	CD
cord-301755-fxfsr9bj	70	9	"	"	''
cord-301755-fxfsr9bj	70	10	,	,	,
cord-301755-fxfsr9bj	70	11	Dulbecco	Dulbecco	NNP
cord-301755-fxfsr9bj	70	12	's	's	POS
cord-301755-fxfsr9bj	70	13	minimal	minimal	JJ
cord-301755-fxfsr9bj	70	14	essential	essential	JJ
cord-301755-fxfsr9bj	70	15	medium	medium	NN
cord-301755-fxfsr9bj	70	16	containing	contain	VBG
cord-301755-fxfsr9bj	70	17	1	1	CD
cord-301755-fxfsr9bj	70	18	%	%	NN
cord-301755-fxfsr9bj	70	19	fetal	fetal	JJ
cord-301755-fxfsr9bj	70	20	calf	calf	NN
cord-301755-fxfsr9bj	70	21	serum	serum	NN
cord-301755-fxfsr9bj	70	22	was	be	VBD
cord-301755-fxfsr9bj	70	23	added	add	VBN
cord-301755-fxfsr9bj	70	24	.	.	.
cord-301755-fxfsr9bj	71	1	The	the	DT
cord-301755-fxfsr9bj	71	2	supernatants	supernatant	NNS
cord-301755-fxfsr9bj	71	3	from	from	IN
cord-301755-fxfsr9bj	71	4	infected	infected	JJ
cord-301755-fxfsr9bj	71	5	cell	cell	NN
cord-301755-fxfsr9bj	71	6	cultures	culture	NNS
cord-301755-fxfsr9bj	71	7	were	be	VBD
cord-301755-fxfsr9bj	71	8	harvested	harvest	VBN
cord-301755-fxfsr9bj	71	9	when	when	WRB
cord-301755-fxfsr9bj	71	10	the	the	DT
cord-301755-fxfsr9bj	71	11	cytopathic	cytopathic	JJ
cord-301755-fxfsr9bj	71	12	effects	effect	NNS
cord-301755-fxfsr9bj	71	13	reached	reach	VBD
cord-301755-fxfsr9bj	71	14	90-l	90-l	CD
cord-301755-fxfsr9bj	71	15	00	00	CD
cord-301755-fxfsr9bj	71	16	%	%	NN
cord-301755-fxfsr9bj	71	17	.	.	.
cord-301755-fxfsr9bj	72	1	The	the	DT
cord-301755-fxfsr9bj	72	2	harvested	harvest	VBN
cord-301755-fxfsr9bj	72	3	viruses	virus	NNS
cord-301755-fxfsr9bj	72	4	were	be	VBD
cord-301755-fxfsr9bj	72	5	examined	examine	VBN
cord-301755-fxfsr9bj	72	6	for	for	IN
cord-301755-fxfsr9bj	72	7	their	-PRON-	PRP$
cord-301755-fxfsr9bj	72	8	resistance	resistance	NN
cord-301755-fxfsr9bj	72	9	to	to	IN
cord-301755-fxfsr9bj	72	10	the	the	DT
cord-301755-fxfsr9bj	72	11	selecting	select	VBG
cord-301755-fxfsr9bj	72	12	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	72	13	to	to	TO
cord-301755-fxfsr9bj	72	14	ensure	ensure	VB
cord-301755-fxfsr9bj	72	15	that	that	IN
cord-301755-fxfsr9bj	72	16	the	the	DT
cord-301755-fxfsr9bj	72	17	viruses	virus	NNS
cord-301755-fxfsr9bj	72	18	used	use	VBN
cord-301755-fxfsr9bj	72	19	for	for	IN
cord-301755-fxfsr9bj	72	20	biochemical	biochemical	JJ
cord-301755-fxfsr9bj	72	21	studies	study	NNS
cord-301755-fxfsr9bj	72	22	maintained	maintain	VBD
cord-301755-fxfsr9bj	72	23	the	the	DT
cord-301755-fxfsr9bj	72	24	original	original	JJ
cord-301755-fxfsr9bj	72	25	phenotype	phenotype	NN
cord-301755-fxfsr9bj	72	26	.	.	.
cord-301755-fxfsr9bj	73	1	The	the	DT
cord-301755-fxfsr9bj	73	2	JHM	JHM	NNP
cord-301755-fxfsr9bj	73	3	-	-	HYPH
cord-301755-fxfsr9bj	73	4	DL	dl	NN
cord-301755-fxfsr9bj	73	5	virus	virus	NN
cord-301755-fxfsr9bj	73	6	was	be	VBD
cord-301755-fxfsr9bj	73	7	grown	grow	VBN
cord-301755-fxfsr9bj	73	8	in	in	IN
cord-301755-fxfsr9bj	73	9	the	the	DT
cord-301755-fxfsr9bj	73	10	same	same	JJ
cord-301755-fxfsr9bj	73	11	way	way	NN
cord-301755-fxfsr9bj	73	12	except	except	IN
cord-301755-fxfsr9bj	73	13	that	that	IN
cord-301755-fxfsr9bj	73	14	no	no	DT
cord-301755-fxfsr9bj	73	15	antibodies	antibody	NNS
cord-301755-fxfsr9bj	73	16	were	be	VBD
cord-301755-fxfsr9bj	73	17	used	use	VBN
cord-301755-fxfsr9bj	73	18	.	.	.
cord-301755-fxfsr9bj	74	1	Viruses	virus	NNS
cord-301755-fxfsr9bj	74	2	were	be	VBD
cord-301755-fxfsr9bj	74	3	purified	purify	VBN
cord-301755-fxfsr9bj	74	4	according	accord	VBG
cord-301755-fxfsr9bj	74	5	to	to	IN
cord-301755-fxfsr9bj	74	6	a	a	DT
cord-301755-fxfsr9bj	74	7	procedure	procedure	NN
cord-301755-fxfsr9bj	74	8	modified	modify	VBN
cord-301755-fxfsr9bj	74	9	from	from	IN
cord-301755-fxfsr9bj	74	10	Makino	Makino	NNP
cord-301755-fxfsr9bj	74	11	et	et	NNP
cord-301755-fxfsr9bj	74	12	a/.	a/.	NN
cord-301755-fxfsr9bj	74	13	(	(	-LRB-
cord-301755-fxfsr9bj	74	14	1983	1983	CD
cord-301755-fxfsr9bj	74	15	)	)	-RRB-
cord-301755-fxfsr9bj	74	16	.	.	.
cord-301755-fxfsr9bj	75	1	Briefly	briefly	RB
cord-301755-fxfsr9bj	75	2	,	,	,
cord-301755-fxfsr9bj	75	3	the	the	DT
cord-301755-fxfsr9bj	75	4	supernatants	supernatant	NNS
cord-301755-fxfsr9bj	75	5	were	be	VBD
cord-301755-fxfsr9bj	75	6	centrifuged	centrifuge	VBN
cord-301755-fxfsr9bj	75	7	at	at	IN
cord-301755-fxfsr9bj	75	8	8000	8000	CD
cord-301755-fxfsr9bj	75	9	rpm	rpm	NN
cord-301755-fxfsr9bj	75	10	for	for	IN
cord-301755-fxfsr9bj	75	11	30	30	CD
cord-301755-fxfsr9bj	75	12	min	min	NN
cord-301755-fxfsr9bj	75	13	to	to	TO
cord-301755-fxfsr9bj	75	14	clear	clear	JJ
cord-301755-fxfsr9bj	75	15	cell	cell	NN
cord-301755-fxfsr9bj	75	16	debris	debris	NN
cord-301755-fxfsr9bj	75	17	and	and	CC
cord-301755-fxfsr9bj	75	18	were	be	VBD
cord-301755-fxfsr9bj	75	19	precipitated	precipitate	VBN
cord-301755-fxfsr9bj	75	20	with	with	IN
cord-301755-fxfsr9bj	75	21	50	50	CD
cord-301755-fxfsr9bj	75	22	%	%	NN
cord-301755-fxfsr9bj	75	23	saturated	saturated	JJ
cord-301755-fxfsr9bj	75	24	am	am	NN
cord-301755-fxfsr9bj	75	25	-	-	HYPH
cord-301755-fxfsr9bj	75	26	monium	monium	NN
cord-301755-fxfsr9bj	75	27	sulfate	sulfate	NN
cord-301755-fxfsr9bj	75	28	for	for	IN
cord-301755-fxfsr9bj	75	29	at	at	RB
cord-301755-fxfsr9bj	75	30	least	least	JJS
cord-301755-fxfsr9bj	75	31	1.5	1.5	CD
cord-301755-fxfsr9bj	75	32	hr	hr	NN
cord-301755-fxfsr9bj	75	33	at	at	IN
cord-301755-fxfsr9bj	75	34	4	4	CD
cord-301755-fxfsr9bj	75	35	"	"	''
cord-301755-fxfsr9bj	75	36	,	,	,
cord-301755-fxfsr9bj	75	37	followed	follow	VBN
cord-301755-fxfsr9bj	75	38	by	by	IN
cord-301755-fxfsr9bj	75	39	centrifugation	centrifugation	NN
cord-301755-fxfsr9bj	75	40	at	at	IN
cord-301755-fxfsr9bj	75	41	8000	8000	CD
cord-301755-fxfsr9bj	75	42	rpm	rpm	NN
cord-301755-fxfsr9bj	75	43	for	for	IN
cord-301755-fxfsr9bj	75	44	20	20	CD
cord-301755-fxfsr9bj	75	45	min	min	NN
cord-301755-fxfsr9bj	75	46	.	.	.
cord-301755-fxfsr9bj	76	1	The	the	DT
cord-301755-fxfsr9bj	76	2	pellets	pellet	NNS
cord-301755-fxfsr9bj	76	3	were	be	VBD
cord-301755-fxfsr9bj	76	4	suspended	suspend	VBN
cord-301755-fxfsr9bj	76	5	in	in	IN
cord-301755-fxfsr9bj	76	6	NTE	NTE	NNP
cord-301755-fxfsr9bj	76	7	(	(	-LRB-
cord-301755-fxfsr9bj	76	8	0.1	0.1	CD
cord-301755-fxfsr9bj	76	9	M	M	NNP
cord-301755-fxfsr9bj	76	10	NaCI	NaCI	NNP
cord-301755-fxfsr9bj	76	11	,	,	,
cord-301755-fxfsr9bj	76	12	0.01	0.01	CD
cord-301755-fxfsr9bj	76	13	MTris	MTris	NNP
cord-301755-fxfsr9bj	76	14	-	-	HYPH
cord-301755-fxfsr9bj	76	15	HCI	HCI	NNP
cord-301755-fxfsr9bj	76	16	,	,	,
cord-301755-fxfsr9bj	76	17	pH	pH	NNP
cord-301755-fxfsr9bj	76	18	7.4	7.4	CD
cord-301755-fxfsr9bj	76	19	,	,	,
cord-301755-fxfsr9bj	76	20	and	and	CC
cord-301755-fxfsr9bj	76	21	1	1	CD
cord-301755-fxfsr9bj	76	22	mM	mm	CD
cord-301755-fxfsr9bj	76	23	EDTA	EDTA	NNP
cord-301755-fxfsr9bj	76	24	)	)	-RRB-
cord-301755-fxfsr9bj	76	25	,	,	,
cord-301755-fxfsr9bj	76	26	and	and	CC
cord-301755-fxfsr9bj	76	27	the	the	DT
cord-301755-fxfsr9bj	76	28	suspensions	suspension	NNS
cord-301755-fxfsr9bj	76	29	were	be	VBD
cord-301755-fxfsr9bj	76	30	centrifuged	centrifuge	VBN
cord-301755-fxfsr9bj	76	31	at	at	IN
cord-301755-fxfsr9bj	76	32	2000	2000	CD
cord-301755-fxfsr9bj	76	33	rpm	rpm	NN
cord-301755-fxfsr9bj	76	34	for	for	IN
cord-301755-fxfsr9bj	76	35	10	10	CD
cord-301755-fxfsr9bj	76	36	min	min	NN
cord-301755-fxfsr9bj	76	37	to	to	TO
cord-301755-fxfsr9bj	76	38	remove	remove	VB
cord-301755-fxfsr9bj	76	39	undissolved	undissolved	JJ
cord-301755-fxfsr9bj	76	40	debris	debris	NN
cord-301755-fxfsr9bj	76	41	.	.	.
cord-301755-fxfsr9bj	77	1	The	the	DT
cord-301755-fxfsr9bj	77	2	supernatants	supernatant	NNS
cord-301755-fxfsr9bj	77	3	were	be	VBD
cord-301755-fxfsr9bj	77	4	then	then	RB
cord-301755-fxfsr9bj	77	5	subjected	subject	VBN
cord-301755-fxfsr9bj	77	6	to	to	IN
cord-301755-fxfsr9bj	77	7	two	two	CD
cord-301755-fxfsr9bj	77	8	rounds	round	NNS
cord-301755-fxfsr9bj	77	9	of	of	IN
cord-301755-fxfsr9bj	77	10	centrifugation	centrifugation	NN
cord-301755-fxfsr9bj	77	11	in	in	IN
cord-301755-fxfsr9bj	77	12	discontinuous	discontinuous	JJ
cord-301755-fxfsr9bj	77	13	sucrose	sucrose	NN
cord-301755-fxfsr9bj	77	14	gradient	gradient	NN
cord-301755-fxfsr9bj	77	15	consisting	consist	VBG
cord-301755-fxfsr9bj	77	16	of	of	IN
cord-301755-fxfsr9bj	77	17	20	20	CD
cord-301755-fxfsr9bj	77	18	,	,	,
cord-301755-fxfsr9bj	77	19	30	30	CD
cord-301755-fxfsr9bj	77	20	,	,	,
cord-301755-fxfsr9bj	77	21	50	50	CD
cord-301755-fxfsr9bj	77	22	,	,	,
cord-301755-fxfsr9bj	77	23	and	and	CC
cord-301755-fxfsr9bj	77	24	60	60	CD
cord-301755-fxfsr9bj	77	25	%	%	NN
cord-301755-fxfsr9bj	77	26	sucrose	sucrose	NN
cord-301755-fxfsr9bj	77	27	in	in	IN
cord-301755-fxfsr9bj	77	28	NTE	NTE	NNP
cord-301755-fxfsr9bj	77	29	at	at	IN
cord-301755-fxfsr9bj	77	30	26,000	26,000	CD
cord-301755-fxfsr9bj	77	31	rpm	rpm	NN
cord-301755-fxfsr9bj	77	32	for	for	IN
cord-301755-fxfsr9bj	77	33	3.5	3.5	CD
cord-301755-fxfsr9bj	77	34	hr	hr	NN
cord-301755-fxfsr9bj	77	35	at	at	IN
cord-301755-fxfsr9bj	77	36	4	4	CD
cord-301755-fxfsr9bj	77	37	"	"	``
cord-301755-fxfsr9bj	77	38	in	in	IN
cord-301755-fxfsr9bj	77	39	a	a	DT
cord-301755-fxfsr9bj	77	40	Beckman	Beckman	NNP
cord-301755-fxfsr9bj	77	41	SW28	SW28	NNP
cord-301755-fxfsr9bj	77	42	rotor	rotor	NN
cord-301755-fxfsr9bj	77	43	.	.	.
cord-301755-fxfsr9bj	78	1	Viruses	virus	NNS
cord-301755-fxfsr9bj	78	2	at	at	IN
cord-301755-fxfsr9bj	78	3	the	the	DT
cord-301755-fxfsr9bj	78	4	30	30	CD
cord-301755-fxfsr9bj	78	5	-	-	SYM
cord-301755-fxfsr9bj	78	6	500	500	CD
cord-301755-fxfsr9bj	79	1	/o	/o	NNP
cord-301755-fxfsr9bj	79	2	interface	interface	NN
cord-301755-fxfsr9bj	79	3	were	be	VBD
cord-301755-fxfsr9bj	79	4	harvested	harvest	VBN
cord-301755-fxfsr9bj	79	5	and	and	CC
cord-301755-fxfsr9bj	79	6	diluted	dilute	VBN
cord-301755-fxfsr9bj	79	7	with	with	IN
cord-301755-fxfsr9bj	79	8	NTE	NTE	NNP
cord-301755-fxfsr9bj	79	9	and	and	CC
cord-301755-fxfsr9bj	79	10	pelleted	pellete	VBN
cord-301755-fxfsr9bj	79	11	by	by	IN
cord-301755-fxfsr9bj	79	12	centrifugation	centrifugation	NN
cord-301755-fxfsr9bj	79	13	at	at	IN
cord-301755-fxfsr9bj	79	14	40,000	40,000	CD
cord-301755-fxfsr9bj	79	15	rpm	rpm	NN
cord-301755-fxfsr9bj	79	16	for	for	IN
cord-301755-fxfsr9bj	79	17	90	90	CD
cord-301755-fxfsr9bj	79	18	min	min	NN
cord-301755-fxfsr9bj	79	19	in	in	IN
cord-301755-fxfsr9bj	79	20	a	a	DT
cord-301755-fxfsr9bj	79	21	Beckman	Beckman	NNP
cord-301755-fxfsr9bj	79	22	SW41	SW41	NNP
cord-301755-fxfsr9bj	79	23	rotor	rotor	NN
cord-301755-fxfsr9bj	79	24	.	.	.
cord-301755-fxfsr9bj	80	1	The	the	DT
cord-301755-fxfsr9bj	80	2	virus	virus	NN
cord-301755-fxfsr9bj	80	3	pellets	pellet	NNS
cord-301755-fxfsr9bj	80	4	were	be	VBD
cord-301755-fxfsr9bj	80	5	resuspended	resuspend	VBN
cord-301755-fxfsr9bj	80	6	in	in	IN
cord-301755-fxfsr9bj	80	7	NTE	NTE	NNP
cord-301755-fxfsr9bj	80	8	.	.	.
cord-301755-fxfsr9bj	81	1	Isolation	isolation	NN
cord-301755-fxfsr9bj	81	2	of	of	IN
cord-301755-fxfsr9bj	81	3	partial	partial	JJ
cord-301755-fxfsr9bj	81	4	revertants	revertant	NNS
cord-301755-fxfsr9bj	81	5	of	of	IN
cord-301755-fxfsr9bj	81	6	neutralizationescape	neutralizationescape	NNP
cord-301755-fxfsr9bj	81	7	variant	variant	NN
cord-301755-fxfsr9bj	82	1	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	82	2	-	-	HYPH
cord-301755-fxfsr9bj	82	3	l	l	NN
cord-301755-fxfsr9bj	82	4	Variant	Variant	NNP
cord-301755-fxfsr9bj	82	5	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	82	6	-	-	HYPH
cord-301755-fxfsr9bj	82	7	l	l	NN
cord-301755-fxfsr9bj	82	8	was	be	VBD
cord-301755-fxfsr9bj	82	9	passaged	passage	VBN
cord-301755-fxfsr9bj	82	10	in	in	IN
cord-301755-fxfsr9bj	82	11	DBT	DBT	NNP
cord-301755-fxfsr9bj	82	12	cells	cell	NNS
cord-301755-fxfsr9bj	82	13	for	for	IN
cord-301755-fxfsr9bj	82	14	10	10	CD
cord-301755-fxfsr9bj	82	15	times	time	NNS
cord-301755-fxfsr9bj	82	16	in	in	IN
cord-301755-fxfsr9bj	82	17	the	the	DT
cord-301755-fxfsr9bj	82	18	absence	absence	NN
cord-301755-fxfsr9bj	82	19	of	of	IN
cord-301755-fxfsr9bj	82	20	any	any	DT
cord-301755-fxfsr9bj	82	21	antibodies	antibody	NNS
cord-301755-fxfsr9bj	82	22	.	.	.
cord-301755-fxfsr9bj	83	1	These	these	DT
cord-301755-fxfsr9bj	83	2	viruses	virus	NNS
cord-301755-fxfsr9bj	83	3	were	be	VBD
cord-301755-fxfsr9bj	83	4	plaque	plaque	NN
cord-301755-fxfsr9bj	83	5	-	-	HYPH
cord-301755-fxfsr9bj	83	6	assayed	assay	VBN
cord-301755-fxfsr9bj	83	7	,	,	,
cord-301755-fxfsr9bj	83	8	and	and	CC
cord-301755-fxfsr9bj	83	9	plaques	plaque	NNS
cord-301755-fxfsr9bj	83	10	were	be	VBD
cord-301755-fxfsr9bj	83	11	randomly	randomly	RB
cord-301755-fxfsr9bj	83	12	picked	pick	VBN
cord-301755-fxfsr9bj	83	13	and	and	CC
cord-301755-fxfsr9bj	83	14	further	further	RB
cord-301755-fxfsr9bj	83	15	purified	purify	VBN
cord-301755-fxfsr9bj	83	16	by	by	IN
cord-301755-fxfsr9bj	83	17	three	three	CD
cord-301755-fxfsr9bj	83	18	rounds	round	NNS
cord-301755-fxfsr9bj	83	19	of	of	IN
cord-301755-fxfsr9bj	83	20	plaque	plaque	NN
cord-301755-fxfsr9bj	83	21	purification	purification	NN
cord-301755-fxfsr9bj	83	22	.	.	.
cord-301755-fxfsr9bj	84	1	Several	several	JJ
cord-301755-fxfsr9bj	84	2	plaques	plaque	NNS
cord-301755-fxfsr9bj	84	3	were	be	VBD
cord-301755-fxfsr9bj	84	4	examined	examine	VBN
cord-301755-fxfsr9bj	84	5	for	for	IN
cord-301755-fxfsr9bj	84	6	their	-PRON-	PRP$
cord-301755-fxfsr9bj	84	7	sensitivity	sensitivity	NN
cord-301755-fxfsr9bj	84	8	to	to	IN
cord-301755-fxfsr9bj	84	9	MAb	MAb	NNPS
cord-301755-fxfsr9bj	84	10	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	84	11	.	.	.
cord-301755-fxfsr9bj	85	1	Large	large	JJ
cord-301755-fxfsr9bj	85	2	pools	pool	NNS
cord-301755-fxfsr9bj	85	3	of	of	IN
cord-301755-fxfsr9bj	85	4	revertants	revertant	NNS
cord-301755-fxfsr9bj	85	5	were	be	VBD
cord-301755-fxfsr9bj	85	6	prepared	prepare	VBN
cord-301755-fxfsr9bj	85	7	and	and	CC
cord-301755-fxfsr9bj	85	8	purified	purify	VBN
cord-301755-fxfsr9bj	85	9	following	follow	VBG
cord-301755-fxfsr9bj	85	10	the	the	DT
cord-301755-fxfsr9bj	85	11	same	same	JJ
cord-301755-fxfsr9bj	85	12	procedure	procedure	NN
cord-301755-fxfsr9bj	85	13	as	as	IN
cord-301755-fxfsr9bj	85	14	described	describe	VBN
cord-301755-fxfsr9bj	85	15	above	above	RB
cord-301755-fxfsr9bj	85	16	.	.	.
cord-301755-fxfsr9bj	86	1	These	these	DT
cord-301755-fxfsr9bj	86	2	plaque	plaque	NN
cord-301755-fxfsr9bj	86	3	-	-	HYPH
cord-301755-fxfsr9bj	86	4	purified	purify	VBN
cord-301755-fxfsr9bj	86	5	revertants	revertant	NNS
cord-301755-fxfsr9bj	86	6	were	be	VBD
cord-301755-fxfsr9bj	86	7	designated	designate	VBN
cord-301755-fxfsr9bj	86	8	as	as	IN
cord-301755-fxfsr9bj	86	9	Vl	Vl	NNP
cord-301755-fxfsr9bj	86	10	0	0	CD
cord-301755-fxfsr9bj	86	11	.	.	.
cord-301755-fxfsr9bj	87	1	cDNA	cdna	NN
cord-301755-fxfsr9bj	87	2	cloning	clone	VBG
cord-301755-fxfsr9bj	87	3	For	for	IN
cord-301755-fxfsr9bj	87	4	viral	viral	JJ
cord-301755-fxfsr9bj	87	5	RNA	RNA	NNP
cord-301755-fxfsr9bj	87	6	extraction	extraction	NN
cord-301755-fxfsr9bj	87	7	,	,	,
cord-301755-fxfsr9bj	87	8	the	the	DT
cord-301755-fxfsr9bj	87	9	virus	virus	NN
cord-301755-fxfsr9bj	87	10	suspension	suspension	NN
cord-301755-fxfsr9bj	87	11	in	in	IN
cord-301755-fxfsr9bj	87	12	NTE	NTE	NNP
cord-301755-fxfsr9bj	87	13	was	be	VBD
cord-301755-fxfsr9bj	87	14	mixed	mix	VBN
cord-301755-fxfsr9bj	87	15	with	with	IN
cord-301755-fxfsr9bj	87	16	an	an	DT
cord-301755-fxfsr9bj	87	17	equal	equal	JJ
cord-301755-fxfsr9bj	87	18	volume	volume	NN
cord-301755-fxfsr9bj	87	19	of	of	IN
cord-301755-fxfsr9bj	87	20	proteinase	proteinase	NN
cord-301755-fxfsr9bj	87	21	K	k	NN
cord-301755-fxfsr9bj	87	22	buffer	buffer	NN
cord-301755-fxfsr9bj	87	23	(	(	-LRB-
cord-301755-fxfsr9bj	87	24	2	2	CD
cord-301755-fxfsr9bj	87	25	%	%	NN
cord-301755-fxfsr9bj	87	26	SDS	SDS	NNP
cord-301755-fxfsr9bj	87	27	,	,	,
cord-301755-fxfsr9bj	87	28	0.025	0.025	CD
cord-301755-fxfsr9bj	87	29	M	M	NNP
cord-301755-fxfsr9bj	87	30	EDTA	EDTA	NNP
cord-301755-fxfsr9bj	87	31	,	,	,
cord-301755-fxfsr9bj	87	32	0.2	0.2	CD
cord-301755-fxfsr9bj	87	33	M	M	NNP
cord-301755-fxfsr9bj	87	34	Tris	Tris	NNP
cord-301755-fxfsr9bj	87	35	-	-	HYPH
cord-301755-fxfsr9bj	87	36	HCI	HCI	NNP
cord-301755-fxfsr9bj	87	37	,	,	,
cord-301755-fxfsr9bj	87	38	pH	pH	NNP
cord-301755-fxfsr9bj	87	39	7.5	7.5	CD
cord-301755-fxfsr9bj	87	40	,	,	,
cord-301755-fxfsr9bj	87	41	and	and	CC
cord-301755-fxfsr9bj	87	42	0.3	0.3	CD
cord-301755-fxfsr9bj	87	43	M	M	NNP
cord-301755-fxfsr9bj	87	44	NaCI	NaCI	NNP
cord-301755-fxfsr9bj	87	45	)	)	-RRB-
cord-301755-fxfsr9bj	87	46	and	and	CC
cord-301755-fxfsr9bj	88	1	proteinase	proteinase	NNP
cord-301755-fxfsr9bj	88	2	K	K	NNP
cord-301755-fxfsr9bj	88	3	(	(	-LRB-
cord-301755-fxfsr9bj	88	4	200	200	CD
cord-301755-fxfsr9bj	88	5	pg	pg	NNP
cord-301755-fxfsr9bj	88	6	/	/	SYM
cord-301755-fxfsr9bj	88	7	mI	mI	NNP
cord-301755-fxfsr9bj	88	8	)	)	-RRB-
cord-301755-fxfsr9bj	88	9	,	,	,
cord-301755-fxfsr9bj	88	10	and	and	CC
cord-301755-fxfsr9bj	88	11	incubated	incubate	VBN
cord-301755-fxfsr9bj	88	12	for	for	IN
cord-301755-fxfsr9bj	88	13	45	45	CD
cord-301755-fxfsr9bj	88	14	min	min	NN
cord-301755-fxfsr9bj	88	15	at	at	IN
cord-301755-fxfsr9bj	88	16	37	37	CD
cord-301755-fxfsr9bj	88	17	"	"	''
cord-301755-fxfsr9bj	88	18	.	.	.
cord-301755-fxfsr9bj	89	1	RNA	RNA	NNP
cord-301755-fxfsr9bj	89	2	was	be	VBD
cord-301755-fxfsr9bj	89	3	extracted	extract	VBN
cord-301755-fxfsr9bj	89	4	twice	twice	RB
cord-301755-fxfsr9bj	89	5	with	with	IN
cord-301755-fxfsr9bj	89	6	phenol	phenol	NN
cord-301755-fxfsr9bj	89	7	/	/	SYM
cord-301755-fxfsr9bj	89	8	chloroform	chloroform	NN
cord-301755-fxfsr9bj	89	9	(	(	-LRB-
cord-301755-fxfsr9bj	89	10	1	1	CD
cord-301755-fxfsr9bj	89	11	:	:	:
cord-301755-fxfsr9bj	89	12	l	l	NN
cord-301755-fxfsr9bj	89	13	)	)	-RRB-
cord-301755-fxfsr9bj	89	14	and	and	CC
cord-301755-fxfsr9bj	89	15	precipitated	precipitate	VBN
cord-301755-fxfsr9bj	89	16	with	with	IN
cord-301755-fxfsr9bj	89	17	ethanol	ethanol	NN
cord-301755-fxfsr9bj	89	18	.	.	.
cord-301755-fxfsr9bj	90	1	The	the	DT
cord-301755-fxfsr9bj	90	2	pelleted	pellete	VBN
cord-301755-fxfsr9bj	90	3	RNA	RNA	NNP
cord-301755-fxfsr9bj	90	4	was	be	VBD
cord-301755-fxfsr9bj	90	5	resuspended	resuspend	VBN
cord-301755-fxfsr9bj	90	6	in	in	IN
cord-301755-fxfsr9bj	90	7	distilled	distilled	JJ
cord-301755-fxfsr9bj	90	8	H	h	NN
cord-301755-fxfsr9bj	90	9	,	,	,
cord-301755-fxfsr9bj	90	10	O	o	UH
cord-301755-fxfsr9bj	90	11	,	,	,
cord-301755-fxfsr9bj	90	12	and	and	CC
cord-301755-fxfsr9bj	90	13	stored	store	VBN
cord-301755-fxfsr9bj	90	14	at	at	IN
cord-301755-fxfsr9bj	90	15	-70	-70	NN
cord-301755-fxfsr9bj	90	16	"	"	''
cord-301755-fxfsr9bj	90	17	.	.	.
cord-301755-fxfsr9bj	91	1	For	for	IN
cord-301755-fxfsr9bj	91	2	cDNA	cdna	NN
cord-301755-fxfsr9bj	91	3	synthesis	synthesis	NN
cord-301755-fxfsr9bj	91	4	,	,	,
cord-301755-fxfsr9bj	91	5	viral	viral	JJ
cord-301755-fxfsr9bj	91	6	RNA	RNA	NNP
cord-301755-fxfsr9bj	91	7	was	be	VBD
cord-301755-fxfsr9bj	91	8	first	first	RB
cord-301755-fxfsr9bj	91	9	denatured	denature	VBN
cord-301755-fxfsr9bj	91	10	with	with	IN
cord-301755-fxfsr9bj	91	11	10	10	CD
cord-301755-fxfsr9bj	91	12	mM	mm	CD
cord-301755-fxfsr9bj	91	13	methylmercury	methylmercury	NN
cord-301755-fxfsr9bj	91	14	at	at	IN
cord-301755-fxfsr9bj	91	15	room	room	NN
cord-301755-fxfsr9bj	91	16	temperature	temperature	NN
cord-301755-fxfsr9bj	91	17	for	for	IN
cord-301755-fxfsr9bj	91	18	10	10	CD
cord-301755-fxfsr9bj	91	19	min	min	NN
cord-301755-fxfsr9bj	91	20	and	and	CC
cord-301755-fxfsr9bj	91	21	then	then	RB
cord-301755-fxfsr9bj	91	22	incubated	incubate	VBD
cord-301755-fxfsr9bj	91	23	at	at	IN
cord-301755-fxfsr9bj	91	24	42	42	CD
cord-301755-fxfsr9bj	91	25	"	"	``
cord-301755-fxfsr9bj	91	26	for	for	IN
cord-301755-fxfsr9bj	91	27	45	45	CD
cord-301755-fxfsr9bj	91	28	to	to	TO
cord-301755-fxfsr9bj	91	29	60	60	CD
cord-301755-fxfsr9bj	91	30	min	min	NN
cord-301755-fxfsr9bj	91	31	in	in	IN
cord-301755-fxfsr9bj	91	32	50	50	CD
cord-301755-fxfsr9bj	91	33	~1	~1	.
cord-301755-fxfsr9bj	92	1	pM	pm	NN
cord-301755-fxfsr9bj	92	2	of	of	IN
cord-301755-fxfsr9bj	92	3	dNTPs	dNTPs	NNP
cord-301755-fxfsr9bj	92	4	,	,	,
cord-301755-fxfsr9bj	92	5	l-3	l-3	NNP
cord-301755-fxfsr9bj	92	6	units	unit	NNS
cord-301755-fxfsr9bj	92	7	of	of	IN
cord-301755-fxfsr9bj	92	8	Taq	Taq	NNP
cord-301755-fxfsr9bj	92	9	polymerase	polymerase	NN
cord-301755-fxfsr9bj	92	10	(	(	-LRB-
cord-301755-fxfsr9bj	92	11	Cetus	Cetus	NNP
cord-301755-fxfsr9bj	92	12	)	)	-RRB-
cord-301755-fxfsr9bj	92	13	,	,	,
cord-301755-fxfsr9bj	92	14	and	and	CC
cord-301755-fxfsr9bj	92	15	0.1-l	0.1-l	CD
cord-301755-fxfsr9bj	92	16	pM	pm	NN
cord-301755-fxfsr9bj	92	17	of	of	IN
cord-301755-fxfsr9bj	92	18	synthetic	synthetic	JJ
cord-301755-fxfsr9bj	92	19	oligonucleotide	oligonucleotide	JJ
cord-301755-fxfsr9bj	92	20	primers	primer	NNS
cord-301755-fxfsr9bj	92	21	(	(	-LRB-
cord-301755-fxfsr9bj	92	22	first	first	JJ
cord-301755-fxfsr9bj	92	23	and	and	CC
cord-301755-fxfsr9bj	92	24	second	second	JJ
cord-301755-fxfsr9bj	92	25	primers	primer	NNS
cord-301755-fxfsr9bj	92	26	)	)	-RRB-
cord-301755-fxfsr9bj	92	27	.	.	.
cord-301755-fxfsr9bj	93	1	The	the	DT
cord-301755-fxfsr9bj	93	2	reaction	reaction	NN
cord-301755-fxfsr9bj	93	3	mixture	mixture	NN
cord-301755-fxfsr9bj	93	4	was	be	VBD
cord-301755-fxfsr9bj	93	5	overlaid	overlay	VBN
cord-301755-fxfsr9bj	93	6	with	with	IN
cord-301755-fxfsr9bj	93	7	60	60	CD
cord-301755-fxfsr9bj	93	8	~1	~1	CD
cord-301755-fxfsr9bj	93	9	of	of	IN
cord-301755-fxfsr9bj	93	10	mineral	mineral	NN
cord-301755-fxfsr9bj	93	11	oil	oil	NN
cord-301755-fxfsr9bj	93	12	and	and	CC
cord-301755-fxfsr9bj	93	13	subjected	subject	VBN
cord-301755-fxfsr9bj	93	14	to	to	IN
cord-301755-fxfsr9bj	93	15	20	20	CD
cord-301755-fxfsr9bj	93	16	-	-	SYM
cord-301755-fxfsr9bj	93	17	40	40	CD
cord-301755-fxfsr9bj	93	18	cycles	cycle	NNS
cord-301755-fxfsr9bj	93	19	of	of	IN
cord-301755-fxfsr9bj	93	20	amplification	amplification	NN
cord-301755-fxfsr9bj	93	21	,	,	,
cord-301755-fxfsr9bj	93	22	each	each	DT
cord-301755-fxfsr9bj	93	23	cycle	cycle	NN
cord-301755-fxfsr9bj	93	24	consisting	consist	VBG
cord-301755-fxfsr9bj	93	25	of	of	IN
cord-301755-fxfsr9bj	93	26	94	94	CD
cord-301755-fxfsr9bj	93	27	"	"	''
cord-301755-fxfsr9bj	93	28	for	for	IN
cord-301755-fxfsr9bj	93	29	1	1	CD
cord-301755-fxfsr9bj	93	30	min	min	NN
cord-301755-fxfsr9bj	93	31	,	,	,
cord-301755-fxfsr9bj	93	32	37	37	CD
cord-301755-fxfsr9bj	93	33	-	-	SYM
cord-301755-fxfsr9bj	93	34	42	42	CD
cord-301755-fxfsr9bj	93	35	"	"	''
cord-301755-fxfsr9bj	93	36	for	for	IN
cord-301755-fxfsr9bj	93	37	l-2	l-2	NNP
cord-301755-fxfsr9bj	93	38	min	min	NNP
cord-301755-fxfsr9bj	93	39	,	,	,
cord-301755-fxfsr9bj	93	40	and	and	CC
cord-301755-fxfsr9bj	93	41	72	72	CD
cord-301755-fxfsr9bj	93	42	"	"	``
cord-301755-fxfsr9bj	93	43	for	for	IN
cord-301755-fxfsr9bj	93	44	2	2	CD
cord-301755-fxfsr9bj	93	45	-	-	SYM
cord-301755-fxfsr9bj	93	46	3	3	CD
cord-301755-fxfsr9bj	93	47	min	min	NN
cord-301755-fxfsr9bj	93	48	.	.	.
cord-301755-fxfsr9bj	94	1	These	these	DT
cord-301755-fxfsr9bj	94	2	PCR	PCR	NNP
cord-301755-fxfsr9bj	94	3	conditions	condition	NNS
cord-301755-fxfsr9bj	94	4	were	be	VBD
cord-301755-fxfsr9bj	94	5	adjusted	adjust	VBN
cord-301755-fxfsr9bj	94	6	slightly	slightly	RB
cord-301755-fxfsr9bj	94	7	for	for	IN
cord-301755-fxfsr9bj	94	8	different	different	JJ
cord-301755-fxfsr9bj	94	9	reactions	reaction	NNS
cord-301755-fxfsr9bj	94	10	,	,	,
cord-301755-fxfsr9bj	94	11	depending	depend	VBG
cord-301755-fxfsr9bj	94	12	on	on	IN
cord-301755-fxfsr9bj	94	13	the	the	DT
cord-301755-fxfsr9bj	94	14	size	size	NN
cord-301755-fxfsr9bj	94	15	of	of	IN
cord-301755-fxfsr9bj	94	16	target	target	NN
cord-301755-fxfsr9bj	94	17	sequence	sequence	NN
cord-301755-fxfsr9bj	94	18	to	to	TO
cord-301755-fxfsr9bj	94	19	be	be	VB
cord-301755-fxfsr9bj	94	20	amplified	amplify	VBN
cord-301755-fxfsr9bj	94	21	and	and	CC
cord-301755-fxfsr9bj	94	22	the	the	DT
cord-301755-fxfsr9bj	94	23	pair	pair	NN
cord-301755-fxfsr9bj	94	24	of	of	IN
cord-301755-fxfsr9bj	94	25	primers	primer	NNS
cord-301755-fxfsr9bj	94	26	used	use	VBN
cord-301755-fxfsr9bj	94	27	.	.	.
cord-301755-fxfsr9bj	95	1	The	the	DT
cord-301755-fxfsr9bj	95	2	PCR	PCR	NNP
cord-301755-fxfsr9bj	95	3	product	product	NN
cord-301755-fxfsr9bj	95	4	was	be	VBD
cord-301755-fxfsr9bj	95	5	resolved	resolve	VBN
cord-301755-fxfsr9bj	95	6	on	on	IN
cord-301755-fxfsr9bj	95	7	a	a	DT
cord-301755-fxfsr9bj	95	8	1	1	CD
cord-301755-fxfsr9bj	95	9	Oh	oh	UH
cord-301755-fxfsr9bj	95	10	agarose	agarose	NN
cord-301755-fxfsr9bj	95	11	gel	gel	NN
cord-301755-fxfsr9bj	95	12	in	in	IN
cord-301755-fxfsr9bj	95	13	1X	1x	JJ
cord-301755-fxfsr9bj	95	14	TBE	TBE	NNP
cord-301755-fxfsr9bj	95	15	buffer	buffer	NN
cord-301755-fxfsr9bj	95	16	(	(	-LRB-
cord-301755-fxfsr9bj	95	17	0.089	0.089	CD
cord-301755-fxfsr9bj	95	18	MlTris	MlTris	NNP
cord-301755-fxfsr9bj	95	19	-	-	HYPH
cord-301755-fxfsr9bj	95	20	HCI	HCI	NNP
cord-301755-fxfsr9bj	95	21	,	,	,
cord-301755-fxfsr9bj	95	22	pH	pH	NNP
cord-301755-fxfsr9bj	95	23	8.3	8.3	CD
cord-301755-fxfsr9bj	95	24	,	,	,
cord-301755-fxfsr9bj	95	25	0.089	0.089	CD
cord-301755-fxfsr9bj	95	26	M	m	CD
cord-301755-fxfsr9bj	95	27	boric	boric	NN
cord-301755-fxfsr9bj	95	28	acid	acid	NN
cord-301755-fxfsr9bj	95	29	,	,	,
cord-301755-fxfsr9bj	95	30	and	and	CC
cord-301755-fxfsr9bj	95	31	2	2	CD
cord-301755-fxfsr9bj	95	32	mM	mm	CD
cord-301755-fxfsr9bj	95	33	EDTA	EDTA	NNP
cord-301755-fxfsr9bj	95	34	)	)	-RRB-
cord-301755-fxfsr9bj	95	35	and	and	CC
cord-301755-fxfsr9bj	95	36	stained	stain	VBN
cord-301755-fxfsr9bj	95	37	with	with	IN
cord-301755-fxfsr9bj	95	38	ethidium	ethidium	NN
cord-301755-fxfsr9bj	95	39	bromide	bromide	NN
cord-301755-fxfsr9bj	95	40	.	.	.
cord-301755-fxfsr9bj	96	1	The	the	DT
cord-301755-fxfsr9bj	96	2	specific	specific	JJ
cord-301755-fxfsr9bj	96	3	product	product	NN
cord-301755-fxfsr9bj	96	4	band	band	NN
cord-301755-fxfsr9bj	96	5	was	be	VBD
cord-301755-fxfsr9bj	96	6	cut	cut	VBN
cord-301755-fxfsr9bj	96	7	out	out	RP
cord-301755-fxfsr9bj	96	8	,	,	,
cord-301755-fxfsr9bj	96	9	and	and	CC
cord-301755-fxfsr9bj	96	10	the	the	DT
cord-301755-fxfsr9bj	96	11	DNA	dna	NN
cord-301755-fxfsr9bj	96	12	was	be	VBD
cord-301755-fxfsr9bj	96	13	extracted	extract	VBN
cord-301755-fxfsr9bj	96	14	from	from	IN
cord-301755-fxfsr9bj	96	15	the	the	DT
cord-301755-fxfsr9bj	96	16	gel	gel	NN
cord-301755-fxfsr9bj	96	17	with	with	IN
cord-301755-fxfsr9bj	96	18	phenol	phenol	NN
cord-301755-fxfsr9bj	96	19	and	and	CC
cord-301755-fxfsr9bj	96	20	chloroform	chloroform	NN
cord-301755-fxfsr9bj	96	21	,	,	,
cord-301755-fxfsr9bj	96	22	precipitated	precipitate	VBN
cord-301755-fxfsr9bj	96	23	with	with	IN
cord-301755-fxfsr9bj	96	24	ethanol	ethanol	NN
cord-301755-fxfsr9bj	96	25	,	,	,
cord-301755-fxfsr9bj	96	26	and	and	CC
cord-301755-fxfsr9bj	96	27	the	the	DT
cord-301755-fxfsr9bj	96	28	pellet	pellet	NN
cord-301755-fxfsr9bj	96	29	suspended	suspend	VBN
cord-301755-fxfsr9bj	96	30	in	in	IN
cord-301755-fxfsr9bj	96	31	distilled	distilled	JJ
cord-301755-fxfsr9bj	96	32	H	h	NN
cord-301755-fxfsr9bj	96	33	,	,	,
cord-301755-fxfsr9bj	96	34	O.	O.	NNP
cord-301755-fxfsr9bj	96	35	The	the	DT
cord-301755-fxfsr9bj	96	36	PCR	PCR	NNP
cord-301755-fxfsr9bj	96	37	product	product	NN
cord-301755-fxfsr9bj	96	38	was	be	VBD
cord-301755-fxfsr9bj	96	39	treated	treat	VBN
cord-301755-fxfsr9bj	96	40	with	with	IN
cord-301755-fxfsr9bj	96	41	10	10	CD
cord-301755-fxfsr9bj	96	42	units	unit	NNS
cord-301755-fxfsr9bj	96	43	of	of	IN
cord-301755-fxfsr9bj	96	44	polynucleotide	polynucleotide	JJ
cord-301755-fxfsr9bj	96	45	kinase	kinase	NNP
cord-301755-fxfsr9bj	96	46	(	(	-LRB-
cord-301755-fxfsr9bj	96	47	Boehringer	Boehringer	NNP
cord-301755-fxfsr9bj	96	48	-	-	HYPH
cord-301755-fxfsr9bj	96	49	Manheim	Manheim	NNP
cord-301755-fxfsr9bj	96	50	)	)	-RRB-
cord-301755-fxfsr9bj	96	51	in	in	IN
cord-301755-fxfsr9bj	96	52	buffer	buffer	NN
cord-301755-fxfsr9bj	96	53	containing	contain	VBG
cord-301755-fxfsr9bj	96	54	0.07	0.07	CD
cord-301755-fxfsr9bj	96	55	M	M	NNP
cord-301755-fxfsr9bj	96	56	Tris	Tris	NNP
cord-301755-fxfsr9bj	96	57	-	-	HYPH
cord-301755-fxfsr9bj	96	58	HCI	HCI	NNP
cord-301755-fxfsr9bj	96	59	,	,	,
cord-301755-fxfsr9bj	96	60	pH	pH	NNP
cord-301755-fxfsr9bj	96	61	8.0	8.0	CD
cord-301755-fxfsr9bj	96	62	,	,	,
cord-301755-fxfsr9bj	96	63	0.01	0.01	CD
cord-301755-fxfsr9bj	96	64	M	M	NNP
cord-301755-fxfsr9bj	96	65	MgCI	MgCI	NNP
cord-301755-fxfsr9bj	96	66	,	,	,
cord-301755-fxfsr9bj	96	67	,	,	,
cord-301755-fxfsr9bj	96	68	5	5	CD
cord-301755-fxfsr9bj	96	69	mM	mm	CD
cord-301755-fxfsr9bj	96	70	DlT	dlt	NN
cord-301755-fxfsr9bj	96	71	,	,	,
cord-301755-fxfsr9bj	96	72	0.1	0.1	CD
cord-301755-fxfsr9bj	96	73	mM	mm	CD
cord-301755-fxfsr9bj	96	74	spermidine	spermidine	NN
cord-301755-fxfsr9bj	96	75	,	,	,
cord-301755-fxfsr9bj	96	76	and	and	CC
cord-301755-fxfsr9bj	96	77	1	1	CD
cord-301755-fxfsr9bj	96	78	mM	mm	CD
cord-301755-fxfsr9bj	96	79	ATP	ATP	NNP
cord-301755-fxfsr9bj	96	80	and	and	CC
cord-301755-fxfsr9bj	96	81	incubated	incubate	VBD
cord-301755-fxfsr9bj	96	82	at	at	IN
cord-301755-fxfsr9bj	96	83	42	42	CD
cord-301755-fxfsr9bj	96	84	"	"	``
cord-301755-fxfsr9bj	96	85	for	for	IN
cord-301755-fxfsr9bj	96	86	45	45	CD
cord-301755-fxfsr9bj	96	87	min	min	NN
cord-301755-fxfsr9bj	96	88	.	.	.
cord-301755-fxfsr9bj	97	1	After	after	IN
cord-301755-fxfsr9bj	97	2	phenol	phenol	NN
cord-301755-fxfsr9bj	97	3	/	/	SYM
cord-301755-fxfsr9bj	97	4	chloroform	chloroform	NN
cord-301755-fxfsr9bj	97	5	extraction	extraction	NN
cord-301755-fxfsr9bj	97	6	and	and	CC
cord-301755-fxfsr9bj	97	7	ethanol	ethanol	NN
cord-301755-fxfsr9bj	97	8	precipitation	precipitation	NN
cord-301755-fxfsr9bj	97	9	,	,	,
cord-301755-fxfsr9bj	97	10	the	the	DT
cord-301755-fxfsr9bj	97	11	PCR	PCR	NNP
cord-301755-fxfsr9bj	97	12	product	product	NN
cord-301755-fxfsr9bj	97	13	was	be	VBD
cord-301755-fxfsr9bj	97	14	blunt	blunt	JJ
cord-301755-fxfsr9bj	97	15	-	-	HYPH
cord-301755-fxfsr9bj	97	16	ended	end	VBN
cord-301755-fxfsr9bj	97	17	with	with	IN
cord-301755-fxfsr9bj	97	18	1	1	CD
cord-301755-fxfsr9bj	97	19	unit	unit	NN
cord-301755-fxfsr9bj	97	20	of	of	IN
cord-301755-fxfsr9bj	97	21	T4	T4	NNP
cord-301755-fxfsr9bj	97	22	DNA	DNA	NNP
cord-301755-fxfsr9bj	97	23	polymerase	polymerase	NN
cord-301755-fxfsr9bj	97	24	(	(	-LRB-
cord-301755-fxfsr9bj	97	25	Boehringer	Boehringer	NNP
cord-301755-fxfsr9bj	97	26	-	-	HYPH
cord-301755-fxfsr9bj	97	27	Manheim	Manheim	NNP
cord-301755-fxfsr9bj	97	28	)	)	-RRB-
cord-301755-fxfsr9bj	97	29	at	at	IN
cord-301755-fxfsr9bj	97	30	37	37	CD
cord-301755-fxfsr9bj	97	31	"	"	``
cord-301755-fxfsr9bj	97	32	for	for	IN
cord-301755-fxfsr9bj	97	33	30	30	CD
cord-301755-fxfsr9bj	97	34	min	min	NN
cord-301755-fxfsr9bj	97	35	in	in	IN
cord-301755-fxfsr9bj	97	36	buffer	buffer	NN
cord-301755-fxfsr9bj	97	37	containing	contain	VBG
cord-301755-fxfsr9bj	97	38	0.05	0.05	CD
cord-301755-fxfsr9bj	97	39	MTris	MTris	NNP
cord-301755-fxfsr9bj	97	40	-	-	HYPH
cord-301755-fxfsr9bj	97	41	HCI	HCI	NNP
cord-301755-fxfsr9bj	97	42	,	,	,
cord-301755-fxfsr9bj	97	43	pH	pH	NNP
cord-301755-fxfsr9bj	97	44	7.5	7.5	CD
cord-301755-fxfsr9bj	97	45	,	,	,
cord-301755-fxfsr9bj	97	46	7	7	CD
cord-301755-fxfsr9bj	97	47	mM	mm	CD
cord-301755-fxfsr9bj	97	48	MgCI	MgCI	NNP
cord-301755-fxfsr9bj	97	49	,	,	,
cord-301755-fxfsr9bj	97	50	,	,	,
cord-301755-fxfsr9bj	97	51	1	1	CD
cord-301755-fxfsr9bj	97	52	mM	mm	CD
cord-301755-fxfsr9bj	97	53	DlT	dlt	NN
cord-301755-fxfsr9bj	97	54	,	,	,
cord-301755-fxfsr9bj	97	55	0.25	0.25	CD
cord-301755-fxfsr9bj	97	56	mM	mm	CD
cord-301755-fxfsr9bj	97	57	of	of	IN
cord-301755-fxfsr9bj	97	58	dNTPs	dntps	CD
cord-301755-fxfsr9bj	97	59	,	,	,
cord-301755-fxfsr9bj	97	60	followed	follow	VBN
cord-301755-fxfsr9bj	97	61	by	by	IN
cord-301755-fxfsr9bj	97	62	a	a	DT
cord-301755-fxfsr9bj	97	63	booster	booster	NN
cord-301755-fxfsr9bj	97	64	reaction	reaction	NN
cord-301755-fxfsr9bj	97	65	with	with	IN
cord-301755-fxfsr9bj	97	66	an	an	DT
cord-301755-fxfsr9bj	97	67	additional	additional	JJ
cord-301755-fxfsr9bj	97	68	0.5	0.5	CD
cord-301755-fxfsr9bj	97	69	unit	unit	NN
cord-301755-fxfsr9bj	97	70	of	of	IN
cord-301755-fxfsr9bj	97	71	T4	T4	NNP
cord-301755-fxfsr9bj	97	72	DNA	DNA	NNP
cord-301755-fxfsr9bj	97	73	polymerase	polymerase	NN
cord-301755-fxfsr9bj	97	74	and	and	CC
cord-301755-fxfsr9bj	97	75	0.05	0.05	CD
cord-301755-fxfsr9bj	97	76	mM	mm	CD
cord-301755-fxfsr9bj	97	77	of	of	IN
cord-301755-fxfsr9bj	97	78	dNTPs	dntps	CD
cord-301755-fxfsr9bj	97	79	at	at	IN
cord-301755-fxfsr9bj	97	80	37	37	CD
cord-301755-fxfsr9bj	97	81	"	"	``
cord-301755-fxfsr9bj	97	82	for	for	IN
cord-301755-fxfsr9bj	97	83	another	another	DT
cord-301755-fxfsr9bj	97	84	30	30	CD
cord-301755-fxfsr9bj	97	85	min	min	NN
cord-301755-fxfsr9bj	97	86	.	.	.
cord-301755-fxfsr9bj	98	1	After	after	IN
cord-301755-fxfsr9bj	98	2	phenol	phenol	NN
cord-301755-fxfsr9bj	98	3	/	/	SYM
cord-301755-fxfsr9bj	98	4	chloroform	chloroform	NN
cord-301755-fxfsr9bj	98	5	extraction	extraction	NN
cord-301755-fxfsr9bj	98	6	,	,	,
cord-301755-fxfsr9bj	98	7	the	the	DT
cord-301755-fxfsr9bj	98	8	PCR	PCR	NNP
cord-301755-fxfsr9bj	98	9	product	product	NN
cord-301755-fxfsr9bj	98	10	was	be	VBD
cord-301755-fxfsr9bj	98	11	ligated	ligate	VBN
cord-301755-fxfsr9bj	98	12	using	use	VBG
cord-301755-fxfsr9bj	98	13	1	1	CD
cord-301755-fxfsr9bj	98	14	unit	unit	NN
cord-301755-fxfsr9bj	98	15	of	of	IN
cord-301755-fxfsr9bj	98	16	T4	T4	NNP
cord-301755-fxfsr9bj	98	17	DNA	DNA	NNP
cord-301755-fxfsr9bj	98	18	ligase	ligase	NN
cord-301755-fxfsr9bj	98	19	(	(	-LRB-
cord-301755-fxfsr9bj	98	20	Boehringer	Boehringer	NNP
cord-301755-fxfsr9bj	98	21	-	-	HYPH
cord-301755-fxfsr9bj	98	22	Manheim	Manheim	NNP
cord-301755-fxfsr9bj	98	23	)	)	-RRB-
cord-301755-fxfsr9bj	98	24	into	into	IN
cord-301755-fxfsr9bj	98	25	the	the	DT
cord-301755-fxfsr9bj	98	26	Smal	Smal	NNP
cord-301755-fxfsr9bj	98	27	site	site	NN
cord-301755-fxfsr9bj	98	28	of	of	IN
cord-301755-fxfsr9bj	98	29	plasmid	plasmid	NN
cord-301755-fxfsr9bj	98	30	pTZ18U	pTZ18U	VBN
cord-301755-fxfsr9bj	98	31	(	(	-LRB-
cord-301755-fxfsr9bj	98	32	U.S.	U.S.	NNP
cord-301755-fxfsr9bj	98	33	Biochemicals	Biochemicals	NNPS
cord-301755-fxfsr9bj	98	34	)	)	-RRB-
cord-301755-fxfsr9bj	98	35	.	.	.
cord-301755-fxfsr9bj	99	1	The	the	DT
cord-301755-fxfsr9bj	99	2	ligation	ligation	NN
cord-301755-fxfsr9bj	99	3	buffer	buffer	NN
cord-301755-fxfsr9bj	99	4	contained	contain	VBD
cord-301755-fxfsr9bj	99	5	0.05	0.05	CD
cord-301755-fxfsr9bj	99	6	M	M	NNP
cord-301755-fxfsr9bj	99	7	Tris	Tris	NNP
cord-301755-fxfsr9bj	99	8	-	-	HYPH
cord-301755-fxfsr9bj	99	9	HCI	HCI	NNP
cord-301755-fxfsr9bj	99	10	,	,	,
cord-301755-fxfsr9bj	99	11	pH	pH	NNP
cord-301755-fxfsr9bj	99	12	7.5	7.5	CD
cord-301755-fxfsr9bj	99	13	,	,	,
cord-301755-fxfsr9bj	99	14	0.01	0.01	CD
cord-301755-fxfsr9bj	99	15	M	M	NNP
cord-301755-fxfsr9bj	99	16	MgCI	MgCI	NNP
cord-301755-fxfsr9bj	99	17	,	,	,
cord-301755-fxfsr9bj	99	18	,	,	,
cord-301755-fxfsr9bj	99	19	2	2	CD
cord-301755-fxfsr9bj	99	20	mM	mm	CD
cord-301755-fxfsr9bj	99	21	DTT	DTT	NNP
cord-301755-fxfsr9bj	99	22	,	,	,
cord-301755-fxfsr9bj	99	23	and	and	CC
cord-301755-fxfsr9bj	99	24	1	1	CD
cord-301755-fxfsr9bj	99	25	mM	mm	CD
cord-301755-fxfsr9bj	99	26	ATP	ATP	NNP
cord-301755-fxfsr9bj	99	27	.	.	.
cord-301755-fxfsr9bj	100	1	The	the	DT
cord-301755-fxfsr9bj	100	2	ligation	ligation	NN
cord-301755-fxfsr9bj	100	3	mixture	mixture	NN
cord-301755-fxfsr9bj	100	4	was	be	VBD
cord-301755-fxfsr9bj	100	5	used	use	VBN
cord-301755-fxfsr9bj	100	6	to	to	TO
cord-301755-fxfsr9bj	100	7	transform	transform	VB
cord-301755-fxfsr9bj	100	8	competent	competent	JJ
cord-301755-fxfsr9bj	100	9	cell	cell	NN
cord-301755-fxfsr9bj	100	10	DH5a	DH5a	NNP
cord-301755-fxfsr9bj	100	11	(	(	-LRB-
cord-301755-fxfsr9bj	100	12	BRL	BRL	NNP
cord-301755-fxfsr9bj	100	13	)	)	-RRB-
cord-301755-fxfsr9bj	100	14	following	follow	VBG
cord-301755-fxfsr9bj	100	15	the	the	DT
cord-301755-fxfsr9bj	100	16	manufacturer	manufacturer	NN
cord-301755-fxfsr9bj	100	17	's	's	POS
cord-301755-fxfsr9bj	100	18	direction	direction	NN
cord-301755-fxfsr9bj	100	19	.	.	.
cord-301755-fxfsr9bj	101	1	DNA	dna	NN
cord-301755-fxfsr9bj	101	2	sequencing	sequencing	NN
cord-301755-fxfsr9bj	101	3	DNA	dna	NN
cord-301755-fxfsr9bj	101	4	sequencing	sequencing	NN
cord-301755-fxfsr9bj	101	5	was	be	VBD
cord-301755-fxfsr9bj	101	6	performed	perform	VBN
cord-301755-fxfsr9bj	101	7	using	use	VBG
cord-301755-fxfsr9bj	101	8	doublestranded	doublestranded	NNP
cord-301755-fxfsr9bj	101	9	DNAof	dnaof	POS
cord-301755-fxfsr9bj	101	10	plasmid	plasmid	NN
cord-301755-fxfsr9bj	101	11	pTZ18U.	pTZ18U.	``
cord-301755-fxfsr9bj	101	12	Dideoxychain	Dideoxychain	NNP
cord-301755-fxfsr9bj	101	13	termination	termination	NN
cord-301755-fxfsr9bj	101	14	sequencing	sequencing	NN
cord-301755-fxfsr9bj	101	15	was	be	VBD
cord-301755-fxfsr9bj	101	16	performed	perform	VBN
cord-301755-fxfsr9bj	101	17	following	follow	VBG
cord-301755-fxfsr9bj	101	18	the	the	DT
cord-301755-fxfsr9bj	101	19	procedure	procedure	NN
cord-301755-fxfsr9bj	101	20	outlined	outline	VBN
cord-301755-fxfsr9bj	101	21	in	in	IN
cord-301755-fxfsr9bj	101	22	the	the	DT
cord-301755-fxfsr9bj	101	23	Sequenase	Sequenase	NNP
cord-301755-fxfsr9bj	101	24	version	version	NN
cord-301755-fxfsr9bj	101	25	2.0	2.0	CD
cord-301755-fxfsr9bj	101	26	DNA	dna	NN
cord-301755-fxfsr9bj	101	27	sequencing	sequencing	NN
cord-301755-fxfsr9bj	101	28	kit	kit	NN
cord-301755-fxfsr9bj	101	29	from	from	IN
cord-301755-fxfsr9bj	101	30	U.S.	U.S.	NNP
cord-301755-fxfsr9bj	101	31	Biochemical	Biochemical	NNP
cord-301755-fxfsr9bj	101	32	.	.	.
cord-301755-fxfsr9bj	102	1	The	the	DT
cord-301755-fxfsr9bj	102	2	reaction	reaction	NN
cord-301755-fxfsr9bj	102	3	product	product	NN
cord-301755-fxfsr9bj	102	4	was	be	VBD
cord-301755-fxfsr9bj	102	5	analyzed	analyze	VBN
cord-301755-fxfsr9bj	102	6	in	in	IN
cord-301755-fxfsr9bj	102	7	69	69	CD
cord-301755-fxfsr9bj	102	8	/	/	SYM
cord-301755-fxfsr9bj	102	9	o	o	NN
cord-301755-fxfsr9bj	102	10	polyacrylamide	polyacrylamide	NN
cord-301755-fxfsr9bj	102	11	gel	gel	NN
cord-301755-fxfsr9bj	102	12	containing	contain	VBG
cord-301755-fxfsr9bj	102	13	7	7	CD
cord-301755-fxfsr9bj	102	14	M	M	NNP
cord-301755-fxfsr9bj	102	15	urea	urea	NN
cord-301755-fxfsr9bj	102	16	.	.	.
cord-301755-fxfsr9bj	103	1	The	the	DT
cord-301755-fxfsr9bj	103	2	whole	whole	JJ
cord-301755-fxfsr9bj	103	3	S	S	NNP
cord-301755-fxfsr9bj	103	4	gene	gene	NN
cord-301755-fxfsr9bj	103	5	,	,	,
cord-301755-fxfsr9bj	103	6	approximately	approximately	RB
cord-301755-fxfsr9bj	103	7	4.2	4.2	CD
cord-301755-fxfsr9bj	103	8	kb	kb	NNS
cord-301755-fxfsr9bj	103	9	in	in	IN
cord-301755-fxfsr9bj	103	10	length	length	NN
cord-301755-fxfsr9bj	103	11	,	,	,
cord-301755-fxfsr9bj	103	12	was	be	VBD
cord-301755-fxfsr9bj	103	13	cloned	clone	VBN
cord-301755-fxfsr9bj	103	14	into	into	IN
cord-301755-fxfsr9bj	103	15	2	2	CD
cord-301755-fxfsr9bj	103	16	to	to	TO
cord-301755-fxfsr9bj	103	17	3	3	CD
cord-301755-fxfsr9bj	103	18	overlapping	overlap	VBG
cord-301755-fxfsr9bj	103	19	fragments	fragment	NNS
cord-301755-fxfsr9bj	103	20	after	after	IN
cord-301755-fxfsr9bj	103	21	amplification	amplification	NN
cord-301755-fxfsr9bj	103	22	by	by	IN
cord-301755-fxfsr9bj	103	23	PCR	PCR	NNP
cord-301755-fxfsr9bj	103	24	using	use	VBG
cord-301755-fxfsr9bj	103	25	appropriate	appropriate	JJ
cord-301755-fxfsr9bj	103	26	synthetic	synthetic	JJ
cord-301755-fxfsr9bj	103	27	primers	primer	NNS
cord-301755-fxfsr9bj	103	28	.	.	.
cord-301755-fxfsr9bj	104	1	Since	since	IN
cord-301755-fxfsr9bj	104	2	we	-PRON-	PRP
cord-301755-fxfsr9bj	104	3	were	be	VBD
cord-301755-fxfsr9bj	104	4	dealing	deal	VBG
cord-301755-fxfsr9bj	104	5	with	with	IN
cord-301755-fxfsr9bj	104	6	several	several	JJ
cord-301755-fxfsr9bj	104	7	viral	viral	JJ
cord-301755-fxfsr9bj	104	8	isolates	isolate	NNS
cord-301755-fxfsr9bj	104	9	with	with	IN
cord-301755-fxfsr9bj	104	10	presumably	presumably	RB
cord-301755-fxfsr9bj	104	11	only	only	RB
cord-301755-fxfsr9bj	104	12	minor	minor	JJ
cord-301755-fxfsr9bj	104	13	differences	difference	NNS
cord-301755-fxfsr9bj	104	14	in	in	IN
cord-301755-fxfsr9bj	104	15	S	S	NNP
cord-301755-fxfsr9bj	104	16	gene	gene	NN
cord-301755-fxfsr9bj	104	17	,	,	,
cord-301755-fxfsr9bj	104	18	crosscontamination	crosscontamination	NN
cord-301755-fxfsr9bj	104	19	was	be	VBD
cord-301755-fxfsr9bj	104	20	a	a	DT
cord-301755-fxfsr9bj	104	21	major	major	JJ
cord-301755-fxfsr9bj	104	22	concern	concern	NN
cord-301755-fxfsr9bj	104	23	.	.	.
cord-301755-fxfsr9bj	105	1	To	to	TO
cord-301755-fxfsr9bj	105	2	avoid	avoid	VB
cord-301755-fxfsr9bj	105	3	this	this	DT
cord-301755-fxfsr9bj	105	4	problem	problem	NN
cord-301755-fxfsr9bj	105	5	,	,	,
cord-301755-fxfsr9bj	105	6	whenever	whenever	WRB
cord-301755-fxfsr9bj	105	7	possible	possible	JJ
cord-301755-fxfsr9bj	105	8	,	,	,
cord-301755-fxfsr9bj	105	9	different	different	JJ
cord-301755-fxfsr9bj	105	10	pairs	pair	NNS
cord-301755-fxfsr9bj	105	11	of	of	IN
cord-301755-fxfsr9bj	105	12	primers	primer	NNS
cord-301755-fxfsr9bj	105	13	were	be	VBD
cord-301755-fxfsr9bj	105	14	used	use	VBN
cord-301755-fxfsr9bj	105	15	in	in	IN
cord-301755-fxfsr9bj	105	16	the	the	DT
cord-301755-fxfsr9bj	105	17	cloning	cloning	NN
cord-301755-fxfsr9bj	105	18	of	of	IN
cord-301755-fxfsr9bj	105	19	different	different	JJ
cord-301755-fxfsr9bj	105	20	viral	viral	JJ
cord-301755-fxfsr9bj	105	21	RNAs	rna	NNS
cord-301755-fxfsr9bj	105	22	so	so	IN
cord-301755-fxfsr9bj	105	23	that	that	IN
cord-301755-fxfsr9bj	105	24	distinguishable	distinguishable	JJ
cord-301755-fxfsr9bj	105	25	gene	gene	NN
cord-301755-fxfsr9bj	105	26	fragments	fragment	NNS
cord-301755-fxfsr9bj	105	27	were	be	VBD
cord-301755-fxfsr9bj	105	28	obtained	obtain	VBN
cord-301755-fxfsr9bj	105	29	for	for	IN
cord-301755-fxfsr9bj	105	30	each	each	DT
cord-301755-fxfsr9bj	105	31	viral	viral	JJ
cord-301755-fxfsr9bj	105	32	isolate	isolate	NN
cord-301755-fxfsr9bj	105	33	.	.	.
cord-301755-fxfsr9bj	106	1	In	in	IN
cord-301755-fxfsr9bj	106	2	cases	case	NNS
cord-301755-fxfsr9bj	106	3	where	where	WRB
cord-301755-fxfsr9bj	106	4	alternative	alternative	JJ
cord-301755-fxfsr9bj	106	5	primers	primer	NNS
cord-301755-fxfsr9bj	106	6	were	be	VBD
cord-301755-fxfsr9bj	106	7	not	not	RB
cord-301755-fxfsr9bj	106	8	available	available	JJ
cord-301755-fxfsr9bj	106	9	,	,	,
cord-301755-fxfsr9bj	106	10	new	new	JJ
cord-301755-fxfsr9bj	106	11	aliquots	aliquot	NNS
cord-301755-fxfsr9bj	106	12	of	of	IN
cord-301755-fxfsr9bj	106	13	reagents	reagent	NNS
cord-301755-fxfsr9bj	106	14	were	be	VBD
cord-301755-fxfsr9bj	106	15	used	use	VBN
cord-301755-fxfsr9bj	106	16	for	for	IN
cord-301755-fxfsr9bj	106	17	each	each	DT
cord-301755-fxfsr9bj	106	18	isolate	isolate	NN
cord-301755-fxfsr9bj	106	19	.	.	.
cord-301755-fxfsr9bj	107	1	Another	another	DT
cord-301755-fxfsr9bj	107	2	concern	concern	NN
cord-301755-fxfsr9bj	107	3	was	be	VBD
cord-301755-fxfsr9bj	107	4	that	that	IN
cord-301755-fxfsr9bj	107	5	the	the	DT
cord-301755-fxfsr9bj	107	6	enzymes	enzyme	NNS
cord-301755-fxfsr9bj	107	7	used	use	VBN
cord-301755-fxfsr9bj	107	8	,	,	,
cord-301755-fxfsr9bj	107	9	namely	namely	RB
cord-301755-fxfsr9bj	107	10	,	,	,
cord-301755-fxfsr9bj	107	11	reverse	reverse	JJ
cord-301755-fxfsr9bj	107	12	transcriptase	transcriptase	NN
cord-301755-fxfsr9bj	107	13	,	,	,
cord-301755-fxfsr9bj	107	14	Taq	taq	NN
cord-301755-fxfsr9bj	107	15	polymerase	polymerase	NN
cord-301755-fxfsr9bj	107	16	,	,	,
cord-301755-fxfsr9bj	107	17	and	and	CC
cord-301755-fxfsr9bj	107	18	Sequenase	Sequenase	NNP
cord-301755-fxfsr9bj	107	19	may	may	MD
cord-301755-fxfsr9bj	107	20	generate	generate	VB
cord-301755-fxfsr9bj	107	21	errors	error	NNS
cord-301755-fxfsr9bj	107	22	.	.	.
cord-301755-fxfsr9bj	108	1	To	to	TO
cord-301755-fxfsr9bj	108	2	avoid	avoid	VB
cord-301755-fxfsr9bj	108	3	this	this	DT
cord-301755-fxfsr9bj	108	4	problem	problem	NN
cord-301755-fxfsr9bj	108	5	,	,	,
cord-301755-fxfsr9bj	108	6	clones	clone	NNS
cord-301755-fxfsr9bj	108	7	from	from	IN
cord-301755-fxfsr9bj	108	8	different	different	JJ
cord-301755-fxfsr9bj	108	9	cDNA	cdna	NN
cord-301755-fxfsr9bj	108	10	synthesis	synthesis	NN
cord-301755-fxfsr9bj	108	11	events	event	NNS
cord-301755-fxfsr9bj	108	12	,	,	,
cord-301755-fxfsr9bj	108	13	different	different	JJ
cord-301755-fxfsr9bj	108	14	PCR	PCR	NNP
cord-301755-fxfsr9bj	108	15	events	event	NNS
cord-301755-fxfsr9bj	108	16	,	,	,
cord-301755-fxfsr9bj	108	17	and	and	CC
cord-301755-fxfsr9bj	108	18	multiple	multiple	JJ
cord-301755-fxfsr9bj	108	19	clones	clone	NNS
cord-301755-fxfsr9bj	108	20	were	be	VBD
cord-301755-fxfsr9bj	108	21	sequenced	sequence	VBN
cord-301755-fxfsr9bj	108	22	.	.	.
cord-301755-fxfsr9bj	109	1	For	for	IN
cord-301755-fxfsr9bj	109	2	each	each	DT
cord-301755-fxfsr9bj	109	3	isolate	isolate	NN
cord-301755-fxfsr9bj	109	4	,	,	,
cord-301755-fxfsr9bj	109	5	the	the	DT
cord-301755-fxfsr9bj	109	6	full	full	JJ
cord-301755-fxfsr9bj	109	7	-	-	HYPH
cord-301755-fxfsr9bj	109	8	length	length	NN
cord-301755-fxfsr9bj	109	9	sequence	sequence	NN
cord-301755-fxfsr9bj	109	10	was	be	VBD
cord-301755-fxfsr9bj	109	11	initially	initially	RB
cord-301755-fxfsr9bj	109	12	obtained	obtain	VBN
cord-301755-fxfsr9bj	109	13	from	from	IN
cord-301755-fxfsr9bj	109	14	two	two	CD
cord-301755-fxfsr9bj	109	15	different	different	JJ
cord-301755-fxfsr9bj	109	16	DNA	dna	NN
cord-301755-fxfsr9bj	109	17	clones	clone	NNS
cord-301755-fxfsr9bj	109	18	.	.	.
cord-301755-fxfsr9bj	110	1	Differences	difference	NNS
cord-301755-fxfsr9bj	110	2	in	in	IN
cord-301755-fxfsr9bj	110	3	sequence	sequence	NN
cord-301755-fxfsr9bj	110	4	identified	identify	VBN
cord-301755-fxfsr9bj	110	5	by	by	IN
cord-301755-fxfsr9bj	110	6	this	this	DT
cord-301755-fxfsr9bj	110	7	initial	initial	JJ
cord-301755-fxfsr9bj	110	8	sequencing	sequencing	NN
cord-301755-fxfsr9bj	110	9	were	be	VBD
cord-301755-fxfsr9bj	110	10	further	further	RB
cord-301755-fxfsr9bj	110	11	studied	study	VBN
cord-301755-fxfsr9bj	110	12	by	by	IN
cord-301755-fxfsr9bj	110	13	sequencing	sequence	VBG
cord-301755-fxfsr9bj	110	14	more	more	JJR
cord-301755-fxfsr9bj	110	15	clones	clone	NNS
cord-301755-fxfsr9bj	110	16	.	.	.
cord-301755-fxfsr9bj	111	1	Only	only	RB
cord-301755-fxfsr9bj	111	2	consistent	consistent	JJ
cord-301755-fxfsr9bj	111	3	changes	change	NNS
cord-301755-fxfsr9bj	111	4	were	be	VBD
cord-301755-fxfsr9bj	111	5	considered	consider	VBN
cord-301755-fxfsr9bj	111	6	as	as	IN
cord-301755-fxfsr9bj	111	7	bona	bona	JJ
cord-301755-fxfsr9bj	111	8	fide	fide	JJ
cord-301755-fxfsr9bj	111	9	mutations	mutation	NNS
cord-301755-fxfsr9bj	111	10	.	.	.
cord-301755-fxfsr9bj	112	1	Some	some	DT
cord-301755-fxfsr9bj	112	2	of	of	IN
cord-301755-fxfsr9bj	112	3	the	the	DT
cord-301755-fxfsr9bj	112	4	sequence	sequence	NN
cord-301755-fxfsr9bj	112	5	variations	variation	NNS
cord-301755-fxfsr9bj	112	6	were	be	VBD
cord-301755-fxfsr9bj	112	7	confirmed	confirm	VBN
cord-301755-fxfsr9bj	112	8	by	by	IN
cord-301755-fxfsr9bj	112	9	direct	direct	JJ
cord-301755-fxfsr9bj	112	10	RNA	RNA	NNP
cord-301755-fxfsr9bj	112	11	sequencing	sequencing	NN
cord-301755-fxfsr9bj	112	12	using	use	VBG
cord-301755-fxfsr9bj	112	13	purified	purify	VBN
cord-301755-fxfsr9bj	112	14	virion	virion	NN
cord-301755-fxfsr9bj	112	15	RNA	RNA	NNP
cord-301755-fxfsr9bj	112	16	(	(	-LRB-
cord-301755-fxfsr9bj	112	17	Banner	Banner	NNP
cord-301755-fxfsr9bj	112	18	et	et	NNP
cord-301755-fxfsr9bj	112	19	a/.	a/.	NNP
cord-301755-fxfsr9bj	112	20	,	,	,
cord-301755-fxfsr9bj	112	21	1990	1990	CD
cord-301755-fxfsr9bj	112	22	)	)	-RRB-
cord-301755-fxfsr9bj	112	23	.	.	.
cord-301755-fxfsr9bj	113	1	The	the	DT
cord-301755-fxfsr9bj	113	2	complete	complete	JJ
cord-301755-fxfsr9bj	113	3	sequences	sequence	NNS
cord-301755-fxfsr9bj	113	4	of	of	IN
cord-301755-fxfsr9bj	113	5	S	S	NNP
cord-301755-fxfsr9bj	113	6	gene	gene	NN
cord-301755-fxfsr9bj	113	7	of	of	IN
cord-301755-fxfsr9bj	113	8	the	the	DT
cord-301755-fxfsr9bj	113	9	parental	parental	JJ
cord-301755-fxfsr9bj	113	10	JHM	JHM	NNP
cord-301755-fxfsr9bj	113	11	-	-	HYPH
cord-301755-fxfsr9bj	113	12	DL	DL	NNP
cord-301755-fxfsr9bj	113	13	and	and	CC
cord-301755-fxfsr9bj	113	14	their	-PRON-	PRP$
cord-301755-fxfsr9bj	113	15	neutralization	neutralization	NN
cord-301755-fxfsr9bj	113	16	-	-	HYPH
cord-301755-fxfsr9bj	113	17	escape	escape	NN
cord-301755-fxfsr9bj	113	18	variants	variant	NNS
cord-301755-fxfsr9bj	113	19	are	be	VBP
cord-301755-fxfsr9bj	113	20	summarized	summarize	VBN
cord-301755-fxfsr9bj	113	21	schematically	schematically	RB
cord-301755-fxfsr9bj	113	22	in	in	IN
cord-301755-fxfsr9bj	113	23	Fig	Fig	NNP
cord-301755-fxfsr9bj	113	24	.	.	.
cord-301755-fxfsr9bj	114	1	1	1	LS
cord-301755-fxfsr9bj	114	2	.	.	.
cord-301755-fxfsr9bj	115	1	The	the	DT
cord-301755-fxfsr9bj	115	2	S	S	NNP
cord-301755-fxfsr9bj	115	3	gene	gene	NN
cord-301755-fxfsr9bj	115	4	of	of	IN
cord-301755-fxfsr9bj	115	5	JHM	JHM	NNP
cord-301755-fxfsr9bj	115	6	-	-	HYPH
cord-301755-fxfsr9bj	115	7	DL	DL	NNP
cord-301755-fxfsr9bj	115	8	is	be	VBZ
cord-301755-fxfsr9bj	115	9	nearly	nearly	RB
cord-301755-fxfsr9bj	115	10	identical	identical	JJ
cord-301755-fxfsr9bj	115	11	to	to	IN
cord-301755-fxfsr9bj	115	12	that	that	DT
cord-301755-fxfsr9bj	115	13	of	of	IN
cord-301755-fxfsr9bj	115	14	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	116	1	(	(	-LRB-
cord-301755-fxfsr9bj	116	2	Parker	Parker	NNP
cord-301755-fxfsr9bj	116	3	et	et	NNP
cord-301755-fxfsr9bj	116	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	116	5	,	,	,
cord-301755-fxfsr9bj	116	6	1989	1989	CD
cord-301755-fxfsr9bj	116	7	)	)	-RRB-
cord-301755-fxfsr9bj	116	8	with	with	IN
cord-301755-fxfsr9bj	116	9	only	only	RB
cord-301755-fxfsr9bj	116	10	6	6	CD
cord-301755-fxfsr9bj	116	11	nucleotide	nucleotide	JJ
cord-301755-fxfsr9bj	116	12	differences	difference	NNS
cord-301755-fxfsr9bj	116	13	(	(	-LRB-
cord-301755-fxfsr9bj	116	14	3	3	CD
cord-301755-fxfsr9bj	116	15	amino	amino	NN
cord-301755-fxfsr9bj	116	16	acid	acid	JJ
cord-301755-fxfsr9bj	116	17	differences	difference	NNS
cord-301755-fxfsr9bj	116	18	)	)	-RRB-
cord-301755-fxfsr9bj	117	1	(	(	-LRB-
cord-301755-fxfsr9bj	117	2	Table	table	NN
cord-301755-fxfsr9bj	117	3	2	2	CD
cord-301755-fxfsr9bj	117	4	)	)	-RRB-
cord-301755-fxfsr9bj	117	5	.	.	.
cord-301755-fxfsr9bj	118	1	It	-PRON-	PRP
cord-301755-fxfsr9bj	118	2	has	have	VBZ
cord-301755-fxfsr9bj	118	3	a	a	DT
cord-301755-fxfsr9bj	118	4	coding	code	VBG
cord-301755-fxfsr9bj	118	5	capacity	capacity	NN
cord-301755-fxfsr9bj	118	6	of	of	IN
cord-301755-fxfsr9bj	118	7	1376	1376	CD
cord-301755-fxfsr9bj	118	8	amino	amino	JJ
cord-301755-fxfsr9bj	118	9	acids	acid	NNS
cord-301755-fxfsr9bj	118	10	.	.	.
cord-301755-fxfsr9bj	119	1	Identical	identical	JJ
cord-301755-fxfsr9bj	119	2	to	to	IN
cord-301755-fxfsr9bj	119	3	those	those	DT
cord-301755-fxfsr9bj	119	4	in	in	IN
cord-301755-fxfsr9bj	119	5	other	other	JJ
cord-301755-fxfsr9bj	119	6	MHVs	mhv	NNS
cord-301755-fxfsr9bj	119	7	(	(	-LRB-
cord-301755-fxfsr9bj	119	8	Schmidt	Schmidt	NNP
cord-301755-fxfsr9bj	119	9	et	et	NNP
cord-301755-fxfsr9bj	119	10	al	al	NNP
cord-301755-fxfsr9bj	119	11	.	.	.
cord-301755-fxfsr9bj	120	1	,	,	,
cord-301755-fxfsr9bj	120	2	1987	1987	CD
cord-301755-fxfsr9bj	120	3	;	;	:
cord-301755-fxfsr9bj	120	4	Luytjes	Luytjes	NNP
cord-301755-fxfsr9bj	120	5	et	et	NNP
cord-301755-fxfsr9bj	120	6	al	al	NNP
cord-301755-fxfsr9bj	120	7	.	.	NNP
cord-301755-fxfsr9bj	120	8	,	,	,
cord-301755-fxfsr9bj	120	9	1987	1987	CD
cord-301755-fxfsr9bj	120	10	)	)	-RRB-
cord-301755-fxfsr9bj	120	11	,	,	,
cord-301755-fxfsr9bj	120	12	the	the	DT
cord-301755-fxfsr9bj	120	13	predicted	predict	VBN
cord-301755-fxfsr9bj	120	14	proteolytic	proteolytic	JJ
cord-301755-fxfsr9bj	120	15	cleavage	cleavage	NN
cord-301755-fxfsr9bj	120	16	site	site	NN
cord-301755-fxfsr9bj	120	17	is	be	VBZ
cord-301755-fxfsr9bj	120	18	between	between	IN
cord-301755-fxfsr9bj	120	19	amino	amino	NN
cord-301755-fxfsr9bj	120	20	acid	acid	NN
cord-301755-fxfsr9bj	120	21	769	769	CD
cord-301755-fxfsr9bj	121	1	(	(	-LRB-
cord-301755-fxfsr9bj	121	2	Arg	Arg	NNP
cord-301755-fxfsr9bj	121	3	)	)	-RRB-
cord-301755-fxfsr9bj	121	4	and	and	CC
cord-301755-fxfsr9bj	121	5	770	770	CD
cord-301755-fxfsr9bj	121	6	(	(	-LRB-
cord-301755-fxfsr9bj	121	7	Ser	Ser	NNP
cord-301755-fxfsr9bj	121	8	)	)	-RRB-
cord-301755-fxfsr9bj	121	9	.	.	.
cord-301755-fxfsr9bj	122	1	The	the	DT
cord-301755-fxfsr9bj	122	2	S	S	NNP
cord-301755-fxfsr9bj	122	3	gene	gene	NN
cord-301755-fxfsr9bj	122	4	of	of	IN
cord-301755-fxfsr9bj	122	5	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	122	6	,	,	,
cord-301755-fxfsr9bj	122	7	which	which	WDT
cord-301755-fxfsr9bj	122	8	was	be	VBD
cord-301755-fxfsr9bj	122	9	derived	derive	VBN
cord-301755-fxfsr9bj	122	10	from	from	IN
cord-301755-fxfsr9bj	122	11	JHM	JHM	NNP
cord-301755-fxfsr9bj	122	12	-	-	HYPH
cord-301755-fxfsr9bj	122	13	DL	DL	NNP
cord-301755-fxfsr9bj	122	14	by	by	IN
cord-301755-fxfsr9bj	122	15	selection	selection	NN
cord-301755-fxfsr9bj	122	16	with	with	IN
cord-301755-fxfsr9bj	122	17	MAb	MAb	NNPS
cord-301755-fxfsr9bj	122	18	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	122	19	,	,	,
cord-301755-fxfsr9bj	122	20	appeared	appear	VBD
cord-301755-fxfsr9bj	122	21	to	to	TO
cord-301755-fxfsr9bj	122	22	consist	consist	VB
cord-301755-fxfsr9bj	122	23	of	of	IN
cord-301755-fxfsr9bj	122	24	two	two	CD
cord-301755-fxfsr9bj	122	25	populations	population	NNS
cord-301755-fxfsr9bj	122	26	.	.	.
cord-301755-fxfsr9bj	123	1	All	all	DT
cord-301755-fxfsr9bj	123	2	of	of	IN
cord-301755-fxfsr9bj	123	3	the	the	DT
cord-301755-fxfsr9bj	123	4	clones	clone	NNS
cord-301755-fxfsr9bj	123	5	contained	contain	VBD
cord-301755-fxfsr9bj	123	6	a	a	DT
cord-301755-fxfsr9bj	123	7	nucleotide	nucleotide	JJ
cord-301755-fxfsr9bj	123	8	difference	difference	NN
cord-301755-fxfsr9bj	123	9	between	between	IN
cord-301755-fxfsr9bj	123	10	JHM	JHM	NNP
cord-301755-fxfsr9bj	123	11	-	-	HYPH
cord-301755-fxfsr9bj	123	12	DL	DL	NNP
cord-301755-fxfsr9bj	123	13	and	and	CC
cord-301755-fxfsr9bj	123	14	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	123	15	,	,	,
cord-301755-fxfsr9bj	123	16	which	which	WDT
cord-301755-fxfsr9bj	123	17	was	be	VBD
cord-301755-fxfsr9bj	123	18	located	locate	VBN
cord-301755-fxfsr9bj	123	19	at	at	IN
cord-301755-fxfsr9bj	123	20	nucleotide	nucleotide	NN
cord-301755-fxfsr9bj	123	21	(	(	-LRB-
cord-301755-fxfsr9bj	123	22	NT	NT	NNP
cord-301755-fxfsr9bj	123	23	)	)	-RRB-
cord-301755-fxfsr9bj	123	24	3340	3340	CD
cord-301755-fxfsr9bj	123	25	,	,	,
cord-301755-fxfsr9bj	123	26	changing	change	VBG
cord-301755-fxfsr9bj	123	27	the	the	DT
cord-301755-fxfsr9bj	123	28	codon	codon	NN
cord-301755-fxfsr9bj	123	29	from	from	IN
cord-301755-fxfsr9bj	123	30	CTC	CTC	NNP
cord-301755-fxfsr9bj	123	31	to	to	IN
cord-301755-fxfsr9bj	123	32	TX	TX	NNP
cord-301755-fxfsr9bj	123	33	(	(	-LRB-
cord-301755-fxfsr9bj	123	34	Leu	Leu	NNP
cord-301755-fxfsr9bj	123	35	to	to	IN
cord-301755-fxfsr9bj	123	36	Phe	Phe	NNP
cord-301755-fxfsr9bj	123	37	)	)	-RRB-
cord-301755-fxfsr9bj	123	38	.	.	.
cord-301755-fxfsr9bj	124	1	Besides	besides	IN
cord-301755-fxfsr9bj	124	2	this	this	DT
cord-301755-fxfsr9bj	124	3	mutation	mutation	NN
cord-301755-fxfsr9bj	124	4	,	,	,
cord-301755-fxfsr9bj	124	5	a	a	DT
cord-301755-fxfsr9bj	124	6	minority	minority	NN
cord-301755-fxfsr9bj	124	7	of	of	IN
cord-301755-fxfsr9bj	124	8	clones	clone	NNS
cord-301755-fxfsr9bj	124	9	contained	contain	VBD
cord-301755-fxfsr9bj	124	10	four	four	CD
cord-301755-fxfsr9bj	124	11	additional	additional	JJ
cord-301755-fxfsr9bj	124	12	mutations	mutation	NNS
cord-301755-fxfsr9bj	124	13	at	at	IN
cord-301755-fxfsr9bj	124	14	the	the	DT
cord-301755-fxfsr9bj	124	15	N	n	CD
cord-301755-fxfsr9bj	124	16	-	-	HYPH
cord-301755-fxfsr9bj	124	17	terminal	terminal	NN
cord-301755-fxfsr9bj	124	18	 	 	_SP
cord-301755-fxfsr9bj	124	19	Note	Note	NNP
cord-301755-fxfsr9bj	124	20	.	.	.
cord-301755-fxfsr9bj	125	1	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	125	2	sequence	sequence	NN
cord-301755-fxfsr9bj	125	3	was	be	VBD
cord-301755-fxfsr9bj	125	4	from	from	IN
cord-301755-fxfsr9bj	125	5	Parker	Parker	NNP
cord-301755-fxfsr9bj	125	6	et	et	NNP
cord-301755-fxfsr9bj	125	7	al	al	NNP
cord-301755-fxfsr9bj	125	8	.	.	.
cord-301755-fxfsr9bj	126	1	(	(	-LRB-
cord-301755-fxfsr9bj	126	2	1989	1989	CD
cord-301755-fxfsr9bj	126	3	)	)	-RRB-
cord-301755-fxfsr9bj	126	4	.	.	.
cord-301755-fxfsr9bj	127	1	Note	note	VB
cord-301755-fxfsr9bj	127	2	.	.	.
cord-301755-fxfsr9bj	128	1	Sequence	sequence	NN
cord-301755-fxfsr9bj	128	2	variations	variation	NNS
cord-301755-fxfsr9bj	128	3	in	in	IN
cord-301755-fxfsr9bj	128	4	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	128	5	-	-	HYPH
cord-301755-fxfsr9bj	128	6	l	l	NN
cord-301755-fxfsr9bj	128	7	were	be	VBD
cord-301755-fxfsr9bj	128	8	found	find	VBN
cord-301755-fxfsr9bj	128	9	consistently	consistently	RB
cord-301755-fxfsr9bj	128	10	in	in	IN
cord-301755-fxfsr9bj	128	11	two	two	CD
cord-301755-fxfsr9bj	128	12	cDNA	cdna	NN
cord-301755-fxfsr9bj	128	13	clones	clone	NNS
cord-301755-fxfsr9bj	128	14	,	,	,
cord-301755-fxfsr9bj	128	15	which	which	WDT
cord-301755-fxfsr9bj	128	16	were	be	VBD
cord-301755-fxfsr9bj	128	17	derived	derive	VBN
cord-301755-fxfsr9bj	128	18	from	from	IN
cord-301755-fxfsr9bj	128	19	different	different	JJ
cord-301755-fxfsr9bj	128	20	reverse	reverse	NN
cord-301755-fxfsr9bj	128	21	transcription	transcription	NN
cord-301755-fxfsr9bj	128	22	events	event	NNS
cord-301755-fxfsr9bj	128	23	and	and	CC
cord-301755-fxfsr9bj	128	24	polymerase	polymerase	NN
cord-301755-fxfsr9bj	128	25	chain	chain	NN
cord-301755-fxfsr9bj	128	26	reactions	reaction	NNS
cord-301755-fxfsr9bj	128	27	.	.	.
cord-301755-fxfsr9bj	129	1	In	in	IN
cord-301755-fxfsr9bj	129	2	contrast	contrast	NN
cord-301755-fxfsr9bj	129	3	,	,	,
cord-301755-fxfsr9bj	129	4	sequence	sequence	NN
cord-301755-fxfsr9bj	129	5	variations	variation	NNS
cord-301755-fxfsr9bj	129	6	in	in	IN
cord-301755-fxfsr9bj	129	7	JHM	JHM	NNP
cord-301755-fxfsr9bj	129	8	-	-	HYPH
cord-301755-fxfsr9bj	129	9	DL	DL	NNP
cord-301755-fxfsr9bj	129	10	were	be	VBD
cord-301755-fxfsr9bj	129	11	found	find	VBN
cord-301755-fxfsr9bj	129	12	randomly	randomly	RB
cord-301755-fxfsr9bj	129	13	in	in	IN
cord-301755-fxfsr9bj	129	14	different	different	JJ
cord-301755-fxfsr9bj	129	15	clones	clone	NNS
cord-301755-fxfsr9bj	129	16	.	.	.
cord-301755-fxfsr9bj	130	1	Frequency	frequency	NN
cord-301755-fxfsr9bj	130	2	indicates	indicate	VBZ
cord-301755-fxfsr9bj	130	3	the	the	DT
cord-301755-fxfsr9bj	130	4	number	number	NN
cord-301755-fxfsr9bj	130	5	of	of	IN
cord-301755-fxfsr9bj	130	6	clones	clone	NNS
cord-301755-fxfsr9bj	130	7	showing	show	VBG
cord-301755-fxfsr9bj	130	8	the	the	DT
cord-301755-fxfsr9bj	130	9	alternative	alternative	JJ
cord-301755-fxfsr9bj	130	10	nucleotide	nucleotide	NN
cord-301755-fxfsr9bj	130	11	out	out	IN
cord-301755-fxfsr9bj	130	12	of	of	IN
cord-301755-fxfsr9bj	130	13	the	the	DT
cord-301755-fxfsr9bj	130	14	total	total	JJ
cord-301755-fxfsr9bj	130	15	number	number	NN
cord-301755-fxfsr9bj	130	16	of	of	IN
cord-301755-fxfsr9bj	130	17	clones	clone	NNS
cord-301755-fxfsr9bj	130	18	that	that	WDT
cord-301755-fxfsr9bj	130	19	were	be	VBD
cord-301755-fxfsr9bj	130	20	sequenced	sequence	VBN
cord-301755-fxfsr9bj	130	21	.	.	.
cord-301755-fxfsr9bj	131	1	end	end	NN
cord-301755-fxfsr9bj	131	2	of	of	IN
cord-301755-fxfsr9bj	131	3	the	the	DT
cord-301755-fxfsr9bj	131	4	S	S	NNP
cord-301755-fxfsr9bj	131	5	gene	gene	NN
cord-301755-fxfsr9bj	131	6	(	(	-LRB-
cord-301755-fxfsr9bj	131	7	Table	Table	NNP
cord-301755-fxfsr9bj	131	8	3	3	CD
cord-301755-fxfsr9bj	131	9	)	)	-RRB-
cord-301755-fxfsr9bj	131	10	.	.	.
cord-301755-fxfsr9bj	132	1	These	these	DT
cord-301755-fxfsr9bj	132	2	were	be	VBD
cord-301755-fxfsr9bj	132	3	located	locate	VBN
cord-301755-fxfsr9bj	132	4	at	at	IN
cord-301755-fxfsr9bj	132	5	NT	NT	NNP
cord-301755-fxfsr9bj	132	6	731	731	CD
cord-301755-fxfsr9bj	132	7	,	,	,
cord-301755-fxfsr9bj	132	8	901	901	CD
cord-301755-fxfsr9bj	132	9	,	,	,
cord-301755-fxfsr9bj	132	10	950	950	CD
cord-301755-fxfsr9bj	132	11	,	,	,
cord-301755-fxfsr9bj	132	12	and	and	CC
cord-301755-fxfsr9bj	132	13	1439	1439	CD
cord-301755-fxfsr9bj	132	14	,	,	,
cord-301755-fxfsr9bj	132	15	changing	change	VBG
cord-301755-fxfsr9bj	132	16	the	the	DT
cord-301755-fxfsr9bj	132	17	codon	codon	NN
cord-301755-fxfsr9bj	132	18	from	from	IN
cord-301755-fxfsr9bj	132	19	lTT	lTT	NNP
cord-301755-fxfsr9bj	132	20	to	to	IN
cord-301755-fxfsr9bj	132	21	TCT	TCT	NNP
cord-301755-fxfsr9bj	132	22	(	(	-LRB-
cord-301755-fxfsr9bj	132	23	Phe	Phe	NNP
cord-301755-fxfsr9bj	132	24	to	to	IN
cord-301755-fxfsr9bj	132	25	Ser	Ser	NNP
cord-301755-fxfsr9bj	132	26	)	)	-RRB-
cord-301755-fxfsr9bj	132	27	,	,	,
cord-301755-fxfsr9bj	132	28	from	from	IN
cord-301755-fxfsr9bj	132	29	CCG	CCG	NNP
cord-301755-fxfsr9bj	132	30	to	to	IN
cord-301755-fxfsr9bj	132	31	TCG	TCG	NNP
cord-301755-fxfsr9bj	132	32	(	(	-LRB-
cord-301755-fxfsr9bj	132	33	Pro	pro	JJ
cord-301755-fxfsr9bj	132	34	to	to	IN
cord-301755-fxfsr9bj	132	35	Ser	Ser	NNP
cord-301755-fxfsr9bj	132	36	)	)	-RRB-
cord-301755-fxfsr9bj	132	37	,	,	,
cord-301755-fxfsr9bj	132	38	from	from	IN
cord-301755-fxfsr9bj	132	39	GGA	GGA	NNP
cord-301755-fxfsr9bj	132	40	to	to	IN
cord-301755-fxfsr9bj	132	41	GAA	GAA	NNP
cord-301755-fxfsr9bj	132	42	(	(	-LRB-
cord-301755-fxfsr9bj	132	43	Gly	Gly	NNP
cord-301755-fxfsr9bj	132	44	to	to	IN
cord-301755-fxfsr9bj	132	45	Glu	Glu	NNP
cord-301755-fxfsr9bj	132	46	)	)	-RRB-
cord-301755-fxfsr9bj	132	47	,	,	,
cord-301755-fxfsr9bj	132	48	and	and	CC
cord-301755-fxfsr9bj	132	49	from	from	IN
cord-301755-fxfsr9bj	132	50	CCG	CCG	NNP
cord-301755-fxfsr9bj	132	51	to	to	IN
cord-301755-fxfsr9bj	132	52	CTG	CTG	NNP
cord-301755-fxfsr9bj	132	53	(	(	-LRB-
cord-301755-fxfsr9bj	132	54	Pro	Pro	NNP
cord-301755-fxfsr9bj	132	55	to	to	IN
cord-301755-fxfsr9bj	132	56	Leu	Leu	NNP
cord-301755-fxfsr9bj	132	57	)	)	-RRB-
cord-301755-fxfsr9bj	132	58	,	,	,
cord-301755-fxfsr9bj	132	59	respectively	respectively	RB
cord-301755-fxfsr9bj	132	60	.	.	.
cord-301755-fxfsr9bj	133	1	These	these	DT
cord-301755-fxfsr9bj	133	2	mutations	mutation	NNS
cord-301755-fxfsr9bj	133	3	were	be	VBD
cord-301755-fxfsr9bj	133	4	not	not	RB
cord-301755-fxfsr9bj	133	5	likely	likely	JJ
cord-301755-fxfsr9bj	133	6	to	to	TO
cord-301755-fxfsr9bj	133	7	be	be	VB
cord-301755-fxfsr9bj	133	8	due	due	JJ
cord-301755-fxfsr9bj	133	9	to	to	IN
cord-301755-fxfsr9bj	133	10	enzyme	enzyme	NN
cord-301755-fxfsr9bj	133	11	errors	error	NNS
cord-301755-fxfsr9bj	133	12	,	,	,
cord-301755-fxfsr9bj	133	13	because	because	IN
cord-301755-fxfsr9bj	133	14	these	these	DT
cord-301755-fxfsr9bj	133	15	mutations	mutation	NNS
cord-301755-fxfsr9bj	133	16	were	be	VBD
cord-301755-fxfsr9bj	133	17	observed	observe	VBN
cord-301755-fxfsr9bj	133	18	on	on	IN
cord-301755-fxfsr9bj	133	19	two	two	CD
cord-301755-fxfsr9bj	133	20	clones	clone	NNS
cord-301755-fxfsr9bj	133	21	derived	derive	VBN
cord-301755-fxfsr9bj	133	22	from	from	IN
cord-301755-fxfsr9bj	133	23	different	different	JJ
cord-301755-fxfsr9bj	133	24	reverse	reverse	NN
cord-301755-fxfsr9bj	133	25	transcription	transcription	NN
cord-301755-fxfsr9bj	133	26	and	and	CC
cord-301755-fxfsr9bj	133	27	PCR	PCR	NNP
cord-301755-fxfsr9bj	133	28	events	event	NNS
cord-301755-fxfsr9bj	133	29	.	.	.
cord-301755-fxfsr9bj	134	1	Sequencing	sequencing	NN
cord-301755-fxfsr9bj	134	2	of	of	IN
cord-301755-fxfsr9bj	134	3	multiple	multiple	JJ
cord-301755-fxfsr9bj	134	4	JHM	JHM	NNP
cord-301755-fxfsr9bj	134	5	-	-	HYPH
cord-301755-fxfsr9bj	134	6	DL	dl	NN
cord-301755-fxfsr9bj	134	7	-	-	HYPH
cord-301755-fxfsr9bj	134	8	derived	derive	VBN
cord-301755-fxfsr9bj	134	9	clones	clone	NNS
cord-301755-fxfsr9bj	134	10	also	also	RB
cord-301755-fxfsr9bj	134	11	showed	show	VBD
cord-301755-fxfsr9bj	134	12	heterogeneity	heterogeneity	NN
cord-301755-fxfsr9bj	134	13	at	at	IN
cord-301755-fxfsr9bj	134	14	several	several	JJ
cord-301755-fxfsr9bj	134	15	different	different	JJ
cord-301755-fxfsr9bj	134	16	nucleotide	nucleotide	JJ
cord-301755-fxfsr9bj	134	17	positions	position	NNS
cord-301755-fxfsr9bj	134	18	(	(	-LRB-
cord-301755-fxfsr9bj	134	19	Table	Table	NNP
cord-301755-fxfsr9bj	134	20	 	 	_SP
cord-301755-fxfsr9bj	134	21	3	3	CD
cord-301755-fxfsr9bj	134	22	)	)	-RRB-
cord-301755-fxfsr9bj	134	23	,	,	,
cord-301755-fxfsr9bj	134	24	which	which	WDT
cord-301755-fxfsr9bj	134	25	were	be	VBD
cord-301755-fxfsr9bj	134	26	different	different	JJ
cord-301755-fxfsr9bj	134	27	from	from	IN
cord-301755-fxfsr9bj	134	28	the	the	DT
cord-301755-fxfsr9bj	134	29	sequence	sequence	NN
cord-301755-fxfsr9bj	134	30	variations	variation	NNS
cord-301755-fxfsr9bj	134	31	observed	observe	VBN
cord-301755-fxfsr9bj	134	32	in	in	IN
cord-301755-fxfsr9bj	134	33	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	134	34	-	-	HYPH
cord-301755-fxfsr9bj	134	35	l	l	NN
cord-301755-fxfsr9bj	134	36	.	.	.
cord-301755-fxfsr9bj	135	1	Since	since	IN
cord-301755-fxfsr9bj	135	2	the	the	DT
cord-301755-fxfsr9bj	135	3	only	only	JJ
cord-301755-fxfsr9bj	135	4	consistent	consistent	JJ
cord-301755-fxfsr9bj	135	5	difference	difference	NN
cord-301755-fxfsr9bj	135	6	between	between	IN
cord-301755-fxfsr9bj	135	7	JHM	JHM	NNP
cord-301755-fxfsr9bj	135	8	-	-	HYPH
cord-301755-fxfsr9bj	135	9	DL	DL	NNP
cord-301755-fxfsr9bj	135	10	and	and	CC
cord-301755-fxfsr9bj	135	11	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	135	12	-	-	HYPH
cord-301755-fxfsr9bj	135	13	l	l	NN
cord-301755-fxfsr9bj	135	14	was	be	VBD
cord-301755-fxfsr9bj	135	15	NT	NT	NNP
cord-301755-fxfsr9bj	135	16	3340	3340	CD
cord-301755-fxfsr9bj	135	17	,	,	,
cord-301755-fxfsr9bj	135	18	this	this	DT
cord-301755-fxfsr9bj	135	19	mutation	mutation	NN
cord-301755-fxfsr9bj	135	20	was	be	VBD
cord-301755-fxfsr9bj	135	21	most	most	RBS
cord-301755-fxfsr9bj	135	22	likely	likely	RB
cord-301755-fxfsr9bj	135	23	responsible	responsible	JJ
cord-301755-fxfsr9bj	135	24	for	for	IN
cord-301755-fxfsr9bj	135	25	the	the	DT
cord-301755-fxfsr9bj	135	26	resistance	resistance	NN
cord-301755-fxfsr9bj	135	27	of	of	IN
cord-301755-fxfsr9bj	135	28	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	135	29	-	-	HYPH
cord-301755-fxfsr9bj	135	30	l	l	NN
cord-301755-fxfsr9bj	135	31	to	to	IN
cord-301755-fxfsr9bj	135	32	MAb	MAb	NNPS
cord-301755-fxfsr9bj	135	33	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	135	34	.	.	.
cord-301755-fxfsr9bj	136	1	However	however	RB
cord-301755-fxfsr9bj	136	2	,	,	,
cord-301755-fxfsr9bj	136	3	the	the	DT
cord-301755-fxfsr9bj	136	4	contribution	contribution	NN
cord-301755-fxfsr9bj	136	5	of	of	IN
cord-301755-fxfsr9bj	136	6	sequence	sequence	NN
cord-301755-fxfsr9bj	136	7	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	136	8	(	(	-LRB-
cord-301755-fxfsr9bj	136	9	Table	table	NN
cord-301755-fxfsr9bj	136	10	3	3	CD
cord-301755-fxfsr9bj	136	11	)	)	-RRB-
cord-301755-fxfsr9bj	136	12	to	to	IN
cord-301755-fxfsr9bj	136	13	the	the	DT
cord-301755-fxfsr9bj	136	14	phenotype	phenotype	NN
cord-301755-fxfsr9bj	136	15	of	of	IN
cord-301755-fxfsr9bj	136	16	viruses	virus	NNS
cord-301755-fxfsr9bj	136	17	could	could	MD
cord-301755-fxfsr9bj	136	18	not	not	RB
cord-301755-fxfsr9bj	136	19	be	be	VB
cord-301755-fxfsr9bj	136	20	ruled	rule	VBN
cord-301755-fxfsr9bj	136	21	out	out	RP
cord-301755-fxfsr9bj	136	22	.	.	.
cord-301755-fxfsr9bj	137	1	It	-PRON-	PRP
cord-301755-fxfsr9bj	137	2	should	should	MD
cord-301755-fxfsr9bj	137	3	be	be	VB
cord-301755-fxfsr9bj	137	4	noted	note	VBN
cord-301755-fxfsr9bj	137	5	that	that	IN
cord-301755-fxfsr9bj	137	6	most	most	JJS
cord-301755-fxfsr9bj	137	7	of	of	IN
cord-301755-fxfsr9bj	137	8	the	the	DT
cord-301755-fxfsr9bj	137	9	minor	minor	JJ
cord-301755-fxfsr9bj	137	10	sequence	sequence	NN
cord-301755-fxfsr9bj	137	11	variations	variation	NNS
cord-301755-fxfsr9bj	137	12	were	be	VBD
cord-301755-fxfsr9bj	137	13	in	in	IN
cord-301755-fxfsr9bj	137	14	the	the	DT
cord-301755-fxfsr9bj	137	15	N	n	CD
cord-301755-fxfsr9bj	137	16	-	-	HYPH
cord-301755-fxfsr9bj	137	17	terminal	terminal	NN
cord-301755-fxfsr9bj	137	18	half	half	NN
cord-301755-fxfsr9bj	137	19	,	,	,
cord-301755-fxfsr9bj	137	20	which	which	WDT
cord-301755-fxfsr9bj	137	21	was	be	VBD
cord-301755-fxfsr9bj	137	22	the	the	DT
cord-301755-fxfsr9bj	137	23	more	more	RBR
cord-301755-fxfsr9bj	137	24	divergent	divergent	JJ
cord-301755-fxfsr9bj	137	25	part	part	NN
cord-301755-fxfsr9bj	137	26	of	of	IN
cord-301755-fxfsr9bj	137	27	the	the	DT
cord-301755-fxfsr9bj	137	28	S	S	NNP
cord-301755-fxfsr9bj	137	29	gene	gene	NN
cord-301755-fxfsr9bj	137	30	(	(	-LRB-
cord-301755-fxfsr9bj	137	31	de	de	FW
cord-301755-fxfsr9bj	137	32	Groot	Groot	NNP
cord-301755-fxfsr9bj	137	33	et	et	NNP
cord-301755-fxfsr9bj	137	34	a/.	a/.	NN
cord-301755-fxfsr9bj	137	35	,	,	,
cord-301755-fxfsr9bj	137	36	1987	1987	CD
cord-301755-fxfsr9bj	137	37	)	)	-RRB-
cord-301755-fxfsr9bj	137	38	.	.	.
cord-301755-fxfsr9bj	138	1	The	the	DT
cord-301755-fxfsr9bj	138	2	variant	variant	NN
cord-301755-fxfsr9bj	138	3	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	138	4	was	be	VBD
cord-301755-fxfsr9bj	138	5	derived	derive	VBN
cord-301755-fxfsr9bj	138	6	from	from	IN
cord-301755-fxfsr9bj	138	7	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	138	8	-	-	HYPH
cord-301755-fxfsr9bj	138	9	l	l	NN
cord-301755-fxfsr9bj	138	10	by	by	IN
cord-301755-fxfsr9bj	138	11	selection	selection	NN
cord-301755-fxfsr9bj	138	12	with	with	IN
cord-301755-fxfsr9bj	138	13	MAb	MAb	NNS
cord-301755-fxfsr9bj	138	14	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	139	1	(	(	-LRB-
cord-301755-fxfsr9bj	139	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	139	3	et	et	NNP
cord-301755-fxfsr9bj	139	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	139	5	,	,	,
cord-301755-fxfsr9bj	139	6	1987	1987	CD
cord-301755-fxfsr9bj	139	7	)	)	-RRB-
cord-301755-fxfsr9bj	139	8	.	.	.
cord-301755-fxfsr9bj	140	1	Sequence	sequence	NN
cord-301755-fxfsr9bj	140	2	analysis	analysis	NN
cord-301755-fxfsr9bj	140	3	showed	show	VBD
cord-301755-fxfsr9bj	140	4	that	that	IN
cord-301755-fxfsr9bj	140	5	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	140	6	had	have	VBD
cord-301755-fxfsr9bj	140	7	a	a	DT
cord-301755-fxfsr9bj	140	8	102nucleotide	102nucleotide	JJ
cord-301755-fxfsr9bj	140	9	deletion	deletion	NN
cord-301755-fxfsr9bj	140	10	at	at	IN
cord-301755-fxfsr9bj	140	11	the	the	DT
cord-301755-fxfsr9bj	140	12	N	n	CD
cord-301755-fxfsr9bj	140	13	-	-	HYPH
cord-301755-fxfsr9bj	140	14	terminal	terminal	NN
cord-301755-fxfsr9bj	140	15	half	half	NN
cord-301755-fxfsr9bj	140	16	between	between	IN
cord-301755-fxfsr9bj	140	17	NT	NT	NNP
cord-301755-fxfsr9bj	140	18	1523	1523	CD
cord-301755-fxfsr9bj	140	19	and	and	CC
cord-301755-fxfsr9bj	140	20	1624	1624	CD
cord-301755-fxfsr9bj	140	21	,	,	,
cord-301755-fxfsr9bj	140	22	corresponding	correspond	VBG
cord-301755-fxfsr9bj	140	23	to	to	IN
cord-301755-fxfsr9bj	140	24	a	a	DT
cord-301755-fxfsr9bj	140	25	34-amino	34-amino	CD
cord-301755-fxfsr9bj	140	26	acid	acid	NN
cord-301755-fxfsr9bj	140	27	deletion	deletion	NN
cord-301755-fxfsr9bj	140	28	.	.	.
cord-301755-fxfsr9bj	141	1	Accompanying	accompany	VBG
cord-301755-fxfsr9bj	141	2	the	the	DT
cord-301755-fxfsr9bj	141	3	deletion	deletion	NN
cord-301755-fxfsr9bj	141	4	,	,	,
cord-301755-fxfsr9bj	141	5	the	the	DT
cord-301755-fxfsr9bj	141	6	two	two	CD
cord-301755-fxfsr9bj	141	7	amino	amino	NN
cord-301755-fxfsr9bj	141	8	acids	acid	NNS
cord-301755-fxfsr9bj	141	9	arginine	arginine	NN
cord-301755-fxfsr9bj	141	10	and	and	CC
cord-301755-fxfsr9bj	141	11	tyrosine	tyrosine	NN
cord-301755-fxfsr9bj	141	12	at	at	IN
cord-301755-fxfsr9bj	141	13	the	the	DT
cord-301755-fxfsr9bj	141	14	junction	junction	NN
cord-301755-fxfsr9bj	141	15	of	of	IN
cord-301755-fxfsr9bj	141	16	deletion	deletion	NN
cord-301755-fxfsr9bj	141	17	were	be	VBD
cord-301755-fxfsr9bj	141	18	converted	convert	VBN
cord-301755-fxfsr9bj	141	19	into	into	IN
cord-301755-fxfsr9bj	141	20	histidine	histidine	NN
cord-301755-fxfsr9bj	141	21	.	.	.
cord-301755-fxfsr9bj	142	1	As	as	IN
cord-301755-fxfsr9bj	142	2	expected	expect	VBN
cord-301755-fxfsr9bj	142	3	,	,	,
cord-301755-fxfsr9bj	142	4	NT	NT	NNP
cord-301755-fxfsr9bj	142	5	3340	3340	CD
cord-301755-fxfsr9bj	142	6	in	in	IN
cord-301755-fxfsr9bj	142	7	this	this	DT
cord-301755-fxfsr9bj	142	8	variant	variant	NN
cord-301755-fxfsr9bj	142	9	remained	remain	VBD
cord-301755-fxfsr9bj	142	10	as	as	IN
cord-301755-fxfsr9bj	142	11	TTC	TTC	NNP
cord-301755-fxfsr9bj	142	12	,	,	,
cord-301755-fxfsr9bj	142	13	similar	similar	JJ
cord-301755-fxfsr9bj	142	14	to	to	IN
cord-301755-fxfsr9bj	142	15	that	that	DT
cord-301755-fxfsr9bj	142	16	in	in	IN
cord-301755-fxfsr9bj	142	17	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	142	18	-	-	HYPH
cord-301755-fxfsr9bj	142	19	l	l	NN
cord-301755-fxfsr9bj	142	20	.	.	.
cord-301755-fxfsr9bj	143	1	Also	also	RB
cord-301755-fxfsr9bj	143	2	,	,	,
cord-301755-fxfsr9bj	143	3	similar	similar	JJ
cord-301755-fxfsr9bj	143	4	to	to	IN
cord-301755-fxfsr9bj	143	5	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	143	6	,	,	,
cord-301755-fxfsr9bj	143	7	a	a	DT
cord-301755-fxfsr9bj	143	8	small	small	JJ
cord-301755-fxfsr9bj	143	9	number	number	NN
cord-301755-fxfsr9bj	143	10	of	of	IN
cord-301755-fxfsr9bj	143	11	clones	clone	NNS
cord-301755-fxfsr9bj	143	12	contained	contain	VBD
cord-301755-fxfsr9bj	143	13	several	several	JJ
cord-301755-fxfsr9bj	143	14	additional	additional	JJ
cord-301755-fxfsr9bj	143	15	point	point	NN
cord-301755-fxfsr9bj	143	16	mutations	mutation	NNS
cord-301755-fxfsr9bj	143	17	at	at	IN
cord-301755-fxfsr9bj	143	18	the	the	DT
cord-301755-fxfsr9bj	143	19	up	up	JJ
cord-301755-fxfsr9bj	143	20	-	-	HYPH
cord-301755-fxfsr9bj	143	21	stream	stream	NN
cord-301755-fxfsr9bj	143	22	and	and	CC
cord-301755-fxfsr9bj	143	23	downstream	downstream	JJ
cord-301755-fxfsr9bj	143	24	regions	region	NNS
cord-301755-fxfsr9bj	143	25	of	of	IN
cord-301755-fxfsr9bj	143	26	the	the	DT
cord-301755-fxfsr9bj	143	27	deletion	deletion	NN
cord-301755-fxfsr9bj	143	28	(	(	-LRB-
cord-301755-fxfsr9bj	143	29	data	datum	NNS
cord-301755-fxfsr9bj	143	30	not	not	RB
cord-301755-fxfsr9bj	143	31	shown	show	VBN
cord-301755-fxfsr9bj	143	32	)	)	-RRB-
cord-301755-fxfsr9bj	143	33	.	.	.
cord-301755-fxfsr9bj	144	1	These	these	DT
cord-301755-fxfsr9bj	144	2	sequence	sequence	NN
cord-301755-fxfsr9bj	144	3	variations	variation	NNS
cord-301755-fxfsr9bj	144	4	were	be	VBD
cord-301755-fxfsr9bj	144	5	different	different	JJ
cord-301755-fxfsr9bj	144	6	from	from	IN
cord-301755-fxfsr9bj	144	7	those	those	DT
cord-301755-fxfsr9bj	144	8	observed	observe	VBN
cord-301755-fxfsr9bj	144	9	in	in	IN
cord-301755-fxfsr9bj	144	10	the	the	DT
cord-301755-fxfsr9bj	144	11	variant	variant	JJ
cord-301755-fxfsr9bj	144	12	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	144	13	-	-	HYPH
cord-301755-fxfsr9bj	144	14	l	l	NN
cord-301755-fxfsr9bj	144	15	.	.	.
cord-301755-fxfsr9bj	145	1	Since	since	IN
cord-301755-fxfsr9bj	145	2	the	the	DT
cord-301755-fxfsr9bj	145	3	102-nucleotide	102-nucleotide	CD
cord-301755-fxfsr9bj	145	4	deletion	deletion	NN
cord-301755-fxfsr9bj	145	5	was	be	VBD
cord-301755-fxfsr9bj	145	6	the	the	DT
cord-301755-fxfsr9bj	145	7	only	only	JJ
cord-301755-fxfsr9bj	145	8	consistent	consistent	JJ
cord-301755-fxfsr9bj	145	9	change	change	NN
cord-301755-fxfsr9bj	145	10	observed	observe	VBN
cord-301755-fxfsr9bj	145	11	in	in	IN
cord-301755-fxfsr9bj	145	12	all	all	DT
cord-301755-fxfsr9bj	145	13	clones	clone	NNS
cord-301755-fxfsr9bj	145	14	of	of	IN
cord-301755-fxfsr9bj	145	15	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	145	16	,	,	,
cord-301755-fxfsr9bj	145	17	it	-PRON-	PRP
cord-301755-fxfsr9bj	145	18	was	be	VBD
cord-301755-fxfsr9bj	145	19	most	most	RBS
cord-301755-fxfsr9bj	145	20	likely	likely	RB
cord-301755-fxfsr9bj	145	21	responsible	responsible	JJ
cord-301755-fxfsr9bj	145	22	for	for	IN
cord-301755-fxfsr9bj	145	23	the	the	DT
cord-301755-fxfsr9bj	145	24	phenotype	phenotype	NN
cord-301755-fxfsr9bj	145	25	differences	difference	NNS
cord-301755-fxfsr9bj	145	26	.	.	.
cord-301755-fxfsr9bj	146	1	To	to	TO
cord-301755-fxfsr9bj	146	2	confirm	confirm	VB
cord-301755-fxfsr9bj	146	3	that	that	IN
cord-301755-fxfsr9bj	146	4	the	the	DT
cord-301755-fxfsr9bj	146	5	deletion	deletion	NN
cord-301755-fxfsr9bj	146	6	in	in	IN
cord-301755-fxfsr9bj	146	7	the	the	DT
cord-301755-fxfsr9bj	146	8	N	n	CD
cord-301755-fxfsr9bj	146	9	-	-	HYPH
cord-301755-fxfsr9bj	146	10	terminal	terminal	JJ
cord-301755-fxfsr9bj	146	11	half	half	NN
cord-301755-fxfsr9bj	146	12	of	of	IN
cord-301755-fxfsr9bj	146	13	S	S	NNP
cord-301755-fxfsr9bj	146	14	was	be	VBD
cord-301755-fxfsr9bj	146	15	responsible	responsible	JJ
cord-301755-fxfsr9bj	146	16	for	for	IN
cord-301755-fxfsr9bj	146	17	the	the	DT
cord-301755-fxfsr9bj	146	18	viral	viral	JJ
cord-301755-fxfsr9bj	146	19	resistance	resistance	NN
cord-301755-fxfsr9bj	146	20	to	to	IN
cord-301755-fxfsr9bj	146	21	MAb	MAb	NNP
cord-301755-fxfsr9bj	146	22	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	146	23	,	,	,
cord-301755-fxfsr9bj	146	24	we	-PRON-	PRP
cord-301755-fxfsr9bj	146	25	sequenced	sequence	VBD
cord-301755-fxfsr9bj	146	26	the	the	DT
cord-301755-fxfsr9bj	146	27	S	S	NNP
cord-301755-fxfsr9bj	146	28	gene	gene	NN
cord-301755-fxfsr9bj	146	29	of	of	IN
cord-301755-fxfsr9bj	146	30	7.2-V-1	7.2-v-1	CD
cord-301755-fxfsr9bj	146	31	,	,	,
cord-301755-fxfsr9bj	146	32	which	which	WDT
cord-301755-fxfsr9bj	146	33	was	be	VBD
cord-301755-fxfsr9bj	146	34	derived	derive	VBN
cord-301755-fxfsr9bj	146	35	directly	directly	RB
cord-301755-fxfsr9bj	146	36	from	from	IN
cord-301755-fxfsr9bj	146	37	JHM	JHM	NNP
cord-301755-fxfsr9bj	146	38	-	-	HYPH
cord-301755-fxfsr9bj	146	39	DL	DL	NNP
cord-301755-fxfsr9bj	146	40	by	by	IN
cord-301755-fxfsr9bj	146	41	selection	selection	NN
cord-301755-fxfsr9bj	146	42	with	with	IN
cord-301755-fxfsr9bj	146	43	MAb	MAb	NNS
cord-301755-fxfsr9bj	146	44	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	147	1	(	(	-LRB-
cord-301755-fxfsr9bj	147	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	147	3	et	et	NNP
cord-301755-fxfsr9bj	147	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	147	5	,	,	,
cord-301755-fxfsr9bj	147	6	1986	1986	CD
cord-301755-fxfsr9bj	147	7	)	)	-RRB-
cord-301755-fxfsr9bj	147	8	.	.	.
cord-301755-fxfsr9bj	148	1	To	to	IN
cord-301755-fxfsr9bj	148	2	our	-PRON-	PRP$
cord-301755-fxfsr9bj	148	3	surprise	surprise	NN
cord-301755-fxfsr9bj	148	4	,	,	,
cord-301755-fxfsr9bj	148	5	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	148	6	-	-	HYPH
cord-301755-fxfsr9bj	148	7	l	l	NNP
cord-301755-fxfsr9bj	148	8	did	do	VBD
cord-301755-fxfsr9bj	148	9	not	not	RB
cord-301755-fxfsr9bj	148	10	have	have	VB
cord-301755-fxfsr9bj	148	11	a	a	DT
cord-301755-fxfsr9bj	148	12	deletion	deletion	NN
cord-301755-fxfsr9bj	148	13	.	.	.
cord-301755-fxfsr9bj	149	1	Instead	instead	RB
cord-301755-fxfsr9bj	149	2	,	,	,
cord-301755-fxfsr9bj	149	3	there	there	EX
cord-301755-fxfsr9bj	149	4	were	be	VBD
cord-301755-fxfsr9bj	149	5	two	two	CD
cord-301755-fxfsr9bj	149	6	point	point	NN
cord-301755-fxfsr9bj	149	7	mutations	mutation	NNS
cord-301755-fxfsr9bj	149	8	consistently	consistently	RB
cord-301755-fxfsr9bj	149	9	detected	detect	VBD
cord-301755-fxfsr9bj	149	10	downstream	downstream	RB
cord-301755-fxfsr9bj	149	11	of	of	IN
cord-301755-fxfsr9bj	149	12	the	the	DT
cord-301755-fxfsr9bj	149	13	2.2/	2.2/	CD
cord-301755-fxfsr9bj	149	14	7.2-V-2	7.2-v-2	CD
cord-301755-fxfsr9bj	149	15	deletion	deletion	NN
cord-301755-fxfsr9bj	149	16	site	site	NN
cord-301755-fxfsr9bj	149	17	,	,	,
cord-301755-fxfsr9bj	149	18	one	one	CD
cord-301755-fxfsr9bj	149	19	at	at	IN
cord-301755-fxfsr9bj	149	20	NT	NT	NNP
cord-301755-fxfsr9bj	149	21	1766	1766	CD
cord-301755-fxfsr9bj	149	22	,	,	,
cord-301755-fxfsr9bj	149	23	changing	change	VBG
cord-301755-fxfsr9bj	149	24	the	the	DT
cord-301755-fxfsr9bj	149	25	codon	codon	NN
cord-301755-fxfsr9bj	149	26	from	from	IN
cord-301755-fxfsr9bj	149	27	TCA	TCA	NNP
cord-301755-fxfsr9bj	149	28	to	to	IN
cord-301755-fxfsr9bj	149	29	TTA	TTA	NNP
cord-301755-fxfsr9bj	149	30	(	(	-LRB-
cord-301755-fxfsr9bj	149	31	Ser	Ser	NNP
cord-301755-fxfsr9bj	149	32	to	to	IN
cord-301755-fxfsr9bj	149	33	Leu	Leu	NNP
cord-301755-fxfsr9bj	149	34	)	)	-RRB-
cord-301755-fxfsr9bj	149	35	and	and	CC
cord-301755-fxfsr9bj	149	36	the	the	DT
cord-301755-fxfsr9bj	149	37	other	other	JJ
cord-301755-fxfsr9bj	149	38	one	one	NN
cord-301755-fxfsr9bj	149	39	at	at	IN
cord-301755-fxfsr9bj	149	40	NT	NT	NNP
cord-301755-fxfsr9bj	149	41	1950	1950	CD
cord-301755-fxfsr9bj	149	42	,	,	,
cord-301755-fxfsr9bj	149	43	changing	change	VBG
cord-301755-fxfsr9bj	149	44	the	the	DT
cord-301755-fxfsr9bj	149	45	codon	codon	NN
cord-301755-fxfsr9bj	149	46	from	from	IN
cord-301755-fxfsr9bj	149	47	AAG	AAG	NNP
cord-301755-fxfsr9bj	149	48	to	to	IN
cord-301755-fxfsr9bj	149	49	AAT	AAT	NNP
cord-301755-fxfsr9bj	149	50	(	(	-LRB-
cord-301755-fxfsr9bj	149	51	Lys	Lys	NNP
cord-301755-fxfsr9bj	149	52	to	to	IN
cord-301755-fxfsr9bj	149	53	Asn	Asn	NNP
cord-301755-fxfsr9bj	149	54	)	)	-RRB-
cord-301755-fxfsr9bj	149	55	.	.	.
cord-301755-fxfsr9bj	150	1	All	all	DT
cord-301755-fxfsr9bj	150	2	of	of	IN
cord-301755-fxfsr9bj	150	3	these	these	DT
cord-301755-fxfsr9bj	150	4	changes	change	NNS
cord-301755-fxfsr9bj	150	5	were	be	VBD
cord-301755-fxfsr9bj	150	6	localized	localize	VBN
cord-301755-fxfsr9bj	150	7	around	around	IN
cord-301755-fxfsr9bj	150	8	the	the	DT
cord-301755-fxfsr9bj	150	9	hypetvariable	hypetvariable	JJ
cord-301755-fxfsr9bj	150	10	region	region	NN
cord-301755-fxfsr9bj	150	11	(	(	-LRB-
cord-301755-fxfsr9bj	150	12	de	de	FW
cord-301755-fxfsr9bj	150	13	Groot	Groot	NNP
cord-301755-fxfsr9bj	150	14	et	et	FW
cord-301755-fxfsr9bj	150	15	al	al	NNP
cord-301755-fxfsr9bj	150	16	.	.	NNP
cord-301755-fxfsr9bj	150	17	,	,	,
cord-301755-fxfsr9bj	150	18	1987	1987	CD
cord-301755-fxfsr9bj	150	19	;	;	:
cord-301755-fxfsr9bj	150	20	Parker	Parker	NNP
cord-301755-fxfsr9bj	150	21	et	et	NNP
cord-301755-fxfsr9bj	150	22	a/.	a/.	NNP
cord-301755-fxfsr9bj	150	23	,	,	,
cord-301755-fxfsr9bj	150	24	1989	1989	CD
cord-301755-fxfsr9bj	150	25	;	;	:
cord-301755-fxfsr9bj	150	26	Banner	Banner	NNP
cord-301755-fxfsr9bj	150	27	et	et	NNP
cord-301755-fxfsr9bj	150	28	a/.	a/.	NNP
cord-301755-fxfsr9bj	150	29	,	,	,
cord-301755-fxfsr9bj	150	30	1990	1990	CD
cord-301755-fxfsr9bj	150	31	)	)	-RRB-
cord-301755-fxfsr9bj	150	32	of	of	IN
cord-301755-fxfsr9bj	150	33	the	the	DT
cord-301755-fxfsr9bj	150	34	S	S	NNP
cord-301755-fxfsr9bj	150	35	protein	protein	NN
cord-301755-fxfsr9bj	150	36	.	.	.
cord-301755-fxfsr9bj	151	1	These	these	DT
cord-301755-fxfsr9bj	151	2	results	result	NNS
cord-301755-fxfsr9bj	151	3	suggested	suggest	VBD
cord-301755-fxfsr9bj	151	4	that	that	IN
cord-301755-fxfsr9bj	151	5	the	the	DT
cord-301755-fxfsr9bj	151	6	mutations	mutation	NNS
cord-301755-fxfsr9bj	151	7	,	,	,
cord-301755-fxfsr9bj	151	8	including	include	VBG
cord-301755-fxfsr9bj	151	9	deletions	deletion	NNS
cord-301755-fxfsr9bj	151	10	and	and	CC
cord-301755-fxfsr9bj	151	11	point	point	NN
cord-301755-fxfsr9bj	151	12	mutations	mutation	NNS
cord-301755-fxfsr9bj	151	13	,	,	,
cord-301755-fxfsr9bj	151	14	in	in	IN
cord-301755-fxfsr9bj	151	15	this	this	DT
cord-301755-fxfsr9bj	151	16	region	region	NN
cord-301755-fxfsr9bj	151	17	were	be	VBD
cord-301755-fxfsr9bj	151	18	most	most	RBS
cord-301755-fxfsr9bj	151	19	likely	likely	RB
cord-301755-fxfsr9bj	151	20	responsible	responsible	JJ
cord-301755-fxfsr9bj	151	21	for	for	IN
cord-301755-fxfsr9bj	151	22	the	the	DT
cord-301755-fxfsr9bj	151	23	viral	viral	JJ
cord-301755-fxfsr9bj	151	24	resistance	resistance	NN
cord-301755-fxfsr9bj	151	25	to	to	IN
cord-301755-fxfsr9bj	151	26	MAb	MAb	NNP
cord-301755-fxfsr9bj	151	27	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	151	28	.	.	.
cord-301755-fxfsr9bj	152	1	NT	NT	NNP
cord-301755-fxfsr9bj	152	2	3340	3340	CD
cord-301755-fxfsr9bj	152	3	of	of	IN
cord-301755-fxfsr9bj	152	4	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	152	5	-	-	HYPH
cord-301755-fxfsr9bj	152	6	l	l	NNP
cord-301755-fxfsr9bj	152	7	remained	remain	VBD
cord-301755-fxfsr9bj	152	8	as	as	IN
cord-301755-fxfsr9bj	152	9	CTC	CTC	NNP
cord-301755-fxfsr9bj	152	10	,	,	,
cord-301755-fxfsr9bj	152	11	similar	similar	JJ
cord-301755-fxfsr9bj	152	12	to	to	IN
cord-301755-fxfsr9bj	152	13	that	that	DT
cord-301755-fxfsr9bj	152	14	in	in	IN
cord-301755-fxfsr9bj	152	15	JHM	JHM	NNP
cord-301755-fxfsr9bj	152	16	-	-	HYPH
cord-301755-fxfsr9bj	152	17	DL	DL	NNP
cord-301755-fxfsr9bj	152	18	,	,	,
cord-301755-fxfsr9bj	152	19	consistent	consistent	JJ
cord-301755-fxfsr9bj	152	20	with	with	IN
cord-301755-fxfsr9bj	152	21	the	the	DT
cord-301755-fxfsr9bj	152	22	fact	fact	NN
cord-301755-fxfsr9bj	152	23	that	that	IN
cord-301755-fxfsr9bj	152	24	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	152	25	-	-	HYPH
cord-301755-fxfsr9bj	152	26	l	l	NNP
cord-301755-fxfsr9bj	152	27	was	be	VBD
cord-301755-fxfsr9bj	152	28	directly	directly	RB
cord-301755-fxfsr9bj	152	29	derived	derive	VBN
cord-301755-fxfsr9bj	152	30	from	from	IN
cord-301755-fxfsr9bj	152	31	JHM	JHM	NNP
cord-301755-fxfsr9bj	152	32	-	-	HYPH
cord-301755-fxfsr9bj	152	33	DL	DL	NNP
cord-301755-fxfsr9bj	152	34	.	.	.
cord-301755-fxfsr9bj	153	1	To	to	TO
cord-301755-fxfsr9bj	153	2	determine	determine	VB
cord-301755-fxfsr9bj	153	3	whether	whether	IN
cord-301755-fxfsr9bj	153	4	the	the	DT
cord-301755-fxfsr9bj	153	5	mutation	mutation	NN
cord-301755-fxfsr9bj	153	6	at	at	IN
cord-301755-fxfsr9bj	153	7	NT	NT	NNP
cord-301755-fxfsr9bj	153	8	3340	3340	CD
cord-301755-fxfsr9bj	153	9	or	or	CC
cord-301755-fxfsr9bj	153	10	the	the	DT
cord-301755-fxfsr9bj	153	11	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	153	12	in	in	IN
cord-301755-fxfsr9bj	153	13	Sl	Sl	NNP
cord-301755-fxfsr9bj	153	14	was	be	VBD
cord-301755-fxfsr9bj	153	15	responsible	responsible	JJ
cord-301755-fxfsr9bj	153	16	for	for	IN
cord-301755-fxfsr9bj	153	17	the	the	DT
cord-301755-fxfsr9bj	153	18	viral	viral	JJ
cord-301755-fxfsr9bj	153	19	resistance	resistance	NN
cord-301755-fxfsr9bj	153	20	to	to	IN
cord-301755-fxfsr9bj	153	21	MAb	MAb	NNS
cord-301755-fxfsr9bj	153	22	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	153	23	and	and	CC
cord-301755-fxfsr9bj	153	24	for	for	IN
cord-301755-fxfsr9bj	153	25	the	the	DT
cord-301755-fxfsr9bj	153	26	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	153	27	of	of	IN
cord-301755-fxfsr9bj	153	28	the	the	DT
cord-301755-fxfsr9bj	153	29	virus	virus	NN
cord-301755-fxfsr9bj	153	30	,	,	,
cord-301755-fxfsr9bj	153	31	we	-PRON-	PRP
cord-301755-fxfsr9bj	153	32	attempted	attempt	VBD
cord-301755-fxfsr9bj	153	33	to	to	TO
cord-301755-fxfsr9bj	153	34	isolate	isolate	VB
cord-301755-fxfsr9bj	153	35	revertants	revertant	NNS
cord-301755-fxfsr9bj	153	36	of	of	IN
cord-301755-fxfsr9bj	153	37	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	153	38	-	-	HYPH
cord-301755-fxfsr9bj	153	39	l	l	NN
cord-301755-fxfsr9bj	153	40	.	.	.
cord-301755-fxfsr9bj	154	1	Variant	variant	NN
cord-301755-fxfsr9bj	154	2	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	154	3	-	-	HYPH
cord-301755-fxfsr9bj	154	4	l	l	NN
cord-301755-fxfsr9bj	154	5	was	be	VBD
cord-301755-fxfsr9bj	154	6	passaged	passage	VBN
cord-301755-fxfsr9bj	154	7	in	in	IN
cord-301755-fxfsr9bj	154	8	DBT	DBT	NNP
cord-301755-fxfsr9bj	154	9	cells	cell	NNS
cord-301755-fxfsr9bj	154	10	in	in	IN
cord-301755-fxfsr9bj	154	11	the	the	DT
cord-301755-fxfsr9bj	154	12	absence	absence	NN
cord-301755-fxfsr9bj	154	13	of	of	IN
cord-301755-fxfsr9bj	154	14	any	any	DT
cord-301755-fxfsr9bj	154	15	MAb	MAb	NNS
cord-301755-fxfsr9bj	154	16	,	,	,
cord-301755-fxfsr9bj	154	17	and	and	CC
cord-301755-fxfsr9bj	154	18	viruses	virus	NNS
cord-301755-fxfsr9bj	154	19	were	be	VBD
cord-301755-fxfsr9bj	154	20	randomly	randomly	RB
cord-301755-fxfsr9bj	154	21	selected	select	VBN
cord-301755-fxfsr9bj	154	22	from	from	IN
cord-301755-fxfsr9bj	154	23	plaques	plaque	NNS
cord-301755-fxfsr9bj	154	24	.	.	.
cord-301755-fxfsr9bj	155	1	Since	since	IN
cord-301755-fxfsr9bj	155	2	the	the	DT
cord-301755-fxfsr9bj	155	3	parental	parental	JJ
cord-301755-fxfsr9bj	155	4	JHM	JHM	NNP
cord-301755-fxfsr9bj	155	5	-	-	HYPH
cord-301755-fxfsr9bj	155	6	DL	DL	NNP
cord-301755-fxfsr9bj	155	7	grew	grow	VBD
cord-301755-fxfsr9bj	155	8	better	well	RBR
cord-301755-fxfsr9bj	155	9	than	than	IN
cord-301755-fxfsr9bj	155	10	the	the	DT
cord-301755-fxfsr9bj	155	11	neutralization	neutralization	NN
cord-301755-fxfsr9bj	155	12	-	-	HYPH
cord-301755-fxfsr9bj	155	13	resistant	resistant	JJ
cord-301755-fxfsr9bj	155	14	variants	variant	NNS
cord-301755-fxfsr9bj	155	15	(	(	-LRB-
cord-301755-fxfsr9bj	155	16	unpublished	unpublished	JJ
cord-301755-fxfsr9bj	155	17	observations	observation	NNS
cord-301755-fxfsr9bj	155	18	)	)	-RRB-
cord-301755-fxfsr9bj	155	19	,	,	,
cord-301755-fxfsr9bj	155	20	we	-PRON-	PRP
cord-301755-fxfsr9bj	155	21	reasoned	reason	VBD
cord-301755-fxfsr9bj	155	22	that	that	IN
cord-301755-fxfsr9bj	155	23	the	the	DT
cord-301755-fxfsr9bj	155	24	revertants	revertant	NNS
cord-301755-fxfsr9bj	155	25	would	would	MD
cord-301755-fxfsr9bj	155	26	become	become	VB
cord-301755-fxfsr9bj	155	27	a	a	DT
cord-301755-fxfsr9bj	155	28	predominant	predominant	JJ
cord-301755-fxfsr9bj	155	29	population	population	NN
cord-301755-fxfsr9bj	155	30	during	during	IN
cord-301755-fxfsr9bj	155	31	serial	serial	JJ
cord-301755-fxfsr9bj	155	32	viral	viral	JJ
cord-301755-fxfsr9bj	155	33	passages	passage	NNS
cord-301755-fxfsr9bj	155	34	in	in	IN
cord-301755-fxfsr9bj	155	35	the	the	DT
cord-301755-fxfsr9bj	155	36	absence	absence	NN
cord-301755-fxfsr9bj	155	37	of	of	IN
cord-301755-fxfsr9bj	155	38	selection	selection	NN
cord-301755-fxfsr9bj	155	39	pressure	pressure	NN
cord-301755-fxfsr9bj	155	40	.	.	.
cord-301755-fxfsr9bj	156	1	Indeed	indeed	RB
cord-301755-fxfsr9bj	156	2	,	,	,
cord-301755-fxfsr9bj	156	3	most	most	JJS
cord-301755-fxfsr9bj	156	4	of	of	IN
cord-301755-fxfsr9bj	156	5	the	the	DT
cord-301755-fxfsr9bj	156	6	plaque	plaque	NN
cord-301755-fxfsr9bj	156	7	-	-	HYPH
cord-301755-fxfsr9bj	156	8	purified	purify	VBN
cord-301755-fxfsr9bj	156	9	viruses	virus	NNS
cord-301755-fxfsr9bj	156	10	isolated	isolate	VBN
cord-301755-fxfsr9bj	156	11	this	this	DT
cord-301755-fxfsr9bj	156	12	way	way	NN
cord-301755-fxfsr9bj	156	13	were	be	VBD
cord-301755-fxfsr9bj	156	14	partially	partially	RB
cord-301755-fxfsr9bj	156	15	sensitive	sensitive	JJ
cord-301755-fxfsr9bj	156	16	to	to	IN
cord-301755-fxfsr9bj	156	17	MAb	MAb	NNS
cord-301755-fxfsr9bj	156	18	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	157	1	(	(	-LRB-
cord-301755-fxfsr9bj	157	2	data	datum	NNS
cord-301755-fxfsr9bj	157	3	not	not	RB
cord-301755-fxfsr9bj	157	4	shown	show	VBN
cord-301755-fxfsr9bj	157	5	)	)	-RRB-
cord-301755-fxfsr9bj	157	6	.	.	.
cord-301755-fxfsr9bj	158	1	Their	-PRON-	PRP$
cord-301755-fxfsr9bj	158	2	titers	titer	NNS
cord-301755-fxfsr9bj	158	3	were	be	VBD
cord-301755-fxfsr9bj	158	4	reduced	reduce	VBN
cord-301755-fxfsr9bj	158	5	by	by	IN
cord-301755-fxfsr9bj	158	6	MAb	MAb	NNS
cord-301755-fxfsr9bj	158	7	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	158	8	by	by	IN
cord-301755-fxfsr9bj	158	9	approximately	approximately	RB
cord-301755-fxfsr9bj	158	10	2.7	2.7	CD
cord-301755-fxfsr9bj	158	11	log	log	NN
cord-301755-fxfsr9bj	158	12	,	,	,
cord-301755-fxfsr9bj	158	13	,	,	,
cord-301755-fxfsr9bj	158	14	,	,	,
cord-301755-fxfsr9bj	158	15	.	.	.
cord-301755-fxfsr9bj	159	1	However	however	RB
cord-301755-fxfsr9bj	159	2	,	,	,
cord-301755-fxfsr9bj	159	3	none	none	NN
cord-301755-fxfsr9bj	159	4	of	of	IN
cord-301755-fxfsr9bj	159	5	the	the	DT
cord-301755-fxfsr9bj	159	6	viruses	virus	NNS
cord-301755-fxfsr9bj	159	7	examined	examine	VBN
cord-301755-fxfsr9bj	159	8	(	(	-LRB-
cord-301755-fxfsr9bj	159	9	N	n	NN
cord-301755-fxfsr9bj	159	10	=	=	SYM
cord-301755-fxfsr9bj	159	11	7	7	CD
cord-301755-fxfsr9bj	159	12	)	)	-RRB-
cord-301755-fxfsr9bj	159	13	completely	completely	RB
cord-301755-fxfsr9bj	159	14	reverted	revert	VBN
cord-301755-fxfsr9bj	159	15	to	to	IN
cord-301755-fxfsr9bj	159	16	the	the	DT
cord-301755-fxfsr9bj	159	17	level	level	NN
cord-301755-fxfsr9bj	159	18	seen	see	VBN
cord-301755-fxfsr9bj	159	19	in	in	IN
cord-301755-fxfsr9bj	159	20	parental	parental	JJ
cord-301755-fxfsr9bj	159	21	JHM	JHM	NNP
cord-301755-fxfsr9bj	159	22	-	-	HYPH
cord-301755-fxfsr9bj	159	23	DL	DL	NNP
cord-301755-fxfsr9bj	159	24	,	,	,
cord-301755-fxfsr9bj	159	25	whose	whose	WP$
cord-301755-fxfsr9bj	159	26	titer	titer	NN
cord-301755-fxfsr9bj	159	27	was	be	VBD
cord-301755-fxfsr9bj	159	28	reduced	reduce	VBN
cord-301755-fxfsr9bj	159	29	by	by	IN
cord-301755-fxfsr9bj	159	30	MAb	MAb	NNS
cord-301755-fxfsr9bj	159	31	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	159	32	by	by	IN
cord-301755-fxfsr9bj	159	33	approximately	approximately	RB
cord-301755-fxfsr9bj	159	34	4	4	CD
cord-301755-fxfsr9bj	159	35	loglo	loglo	NNP
cord-301755-fxfsr9bj	159	36	(	(	-LRB-
cord-301755-fxfsr9bj	160	1	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	160	2	et	et	NNP
cord-301755-fxfsr9bj	160	3	al	al	NNP
cord-301755-fxfsr9bj	160	4	.	.	.
cord-301755-fxfsr9bj	161	1	,	,	,
cord-301755-fxfsr9bj	161	2	1986	1986	CD
cord-301755-fxfsr9bj	161	3	(	(	-LRB-
cord-301755-fxfsr9bj	161	4	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	161	5	et	et	NNP
cord-301755-fxfsr9bj	161	6	al	al	NNP
cord-301755-fxfsr9bj	161	7	.	.	NNP
cord-301755-fxfsr9bj	161	8	,	,	,
cord-301755-fxfsr9bj	161	9	,	,	,
cord-301755-fxfsr9bj	161	10	1987	1987	CD
cord-301755-fxfsr9bj	161	11	.	.	.
cord-301755-fxfsr9bj	162	1	Sequence	sequence	NN
cord-301755-fxfsr9bj	162	2	analysis	analysis	NN
cord-301755-fxfsr9bj	162	3	of	of	IN
cord-301755-fxfsr9bj	162	4	multiple	multiple	JJ
cord-301755-fxfsr9bj	162	5	clones	clone	NNS
cord-301755-fxfsr9bj	162	6	from	from	IN
cord-301755-fxfsr9bj	162	7	all	all	DT
cord-301755-fxfsr9bj	162	8	seven	seven	CD
cord-301755-fxfsr9bj	162	9	partial	partial	JJ
cord-301755-fxfsr9bj	162	10	revertants	revertant	NNS
cord-301755-fxfsr9bj	162	11	showed	show	VBD
cord-301755-fxfsr9bj	162	12	that	that	IN
cord-301755-fxfsr9bj	162	13	all	all	DT
cord-301755-fxfsr9bj	162	14	of	of	IN
cord-301755-fxfsr9bj	162	15	them	-PRON-	PRP
cord-301755-fxfsr9bj	162	16	have	have	VBP
cord-301755-fxfsr9bj	162	17	retained	retain	VBN
cord-301755-fxfsr9bj	162	18	the	the	DT
cord-301755-fxfsr9bj	162	19	sequence	sequence	NN
cord-301755-fxfsr9bj	162	20	of	of	IN
cord-301755-fxfsr9bj	162	21	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	162	22	-	-	HYPH
cord-301755-fxfsr9bj	162	23	l	l	NN
cord-301755-fxfsr9bj	162	24	at	at	IN
cord-301755-fxfsr9bj	162	25	NT	NT	NNP
cord-301755-fxfsr9bj	162	26	3340	3340	CD
cord-301755-fxfsr9bj	162	27	,	,	,
cord-301755-fxfsr9bj	162	28	which	which	WDT
cord-301755-fxfsr9bj	162	29	was	be	VBD
cord-301755-fxfsr9bj	162	30	the	the	DT
cord-301755-fxfsr9bj	162	31	only	only	JJ
cord-301755-fxfsr9bj	162	32	consistent	consistent	JJ
cord-301755-fxfsr9bj	162	33	difference	difference	NN
cord-301755-fxfsr9bj	162	34	observed	observe	VBN
cord-301755-fxfsr9bj	162	35	between	between	IN
cord-301755-fxfsr9bj	162	36	JHM	JHM	NNP
cord-301755-fxfsr9bj	162	37	-	-	HYPH
cord-301755-fxfsr9bj	162	38	DL	DL	NNP
cord-301755-fxfsr9bj	162	39	and	and	CC
cord-301755-fxfsr9bj	162	40	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	162	41	-	-	HYPH
cord-301755-fxfsr9bj	162	42	l	l	NN
cord-301755-fxfsr9bj	162	43	.	.	.
cord-301755-fxfsr9bj	163	1	One	one	CD
cord-301755-fxfsr9bj	163	2	of	of	IN
cord-301755-fxfsr9bj	163	3	these	these	DT
cord-301755-fxfsr9bj	163	4	revertants	revertant	NNS
cord-301755-fxfsr9bj	163	5	was	be	VBD
cord-301755-fxfsr9bj	163	6	chosen	choose	VBN
cord-301755-fxfsr9bj	163	7	for	for	IN
cord-301755-fxfsr9bj	163	8	complete	complete	JJ
cord-301755-fxfsr9bj	163	9	sequencing	sequencing	NN
cord-301755-fxfsr9bj	163	10	;	;	:
cord-301755-fxfsr9bj	163	11	this	this	DT
cord-301755-fxfsr9bj	163	12	virus	virus	NN
cord-301755-fxfsr9bj	163	13	had	have	VBD
cord-301755-fxfsr9bj	163	14	a	a	DT
cord-301755-fxfsr9bj	163	15	consistent	consistent	JJ
cord-301755-fxfsr9bj	163	16	change	change	NN
cord-301755-fxfsr9bj	163	17	at	at	IN
cord-301755-fxfsr9bj	163	18	a	a	DT
cord-301755-fxfsr9bj	163	19	second	second	JJ
cord-301755-fxfsr9bj	163	20	site	site	NN
cord-301755-fxfsr9bj	163	21	at	at	IN
cord-301755-fxfsr9bj	163	22	NT	NT	NNP
cord-301755-fxfsr9bj	163	23	1994	1994	CD
cord-301755-fxfsr9bj	163	24	,	,	,
cord-301755-fxfsr9bj	163	25	changing	change	VBG
cord-301755-fxfsr9bj	163	26	the	the	DT
cord-301755-fxfsr9bj	163	27	codon	codon	NN
cord-301755-fxfsr9bj	163	28	from	from	IN
cord-301755-fxfsr9bj	163	29	AAT	AAT	NNP
cord-301755-fxfsr9bj	163	30	(	(	-LRB-
cord-301755-fxfsr9bj	163	31	Asn	Asn	NNP
cord-301755-fxfsr9bj	163	32	)	)	-RRB-
cord-301755-fxfsr9bj	163	33	to	to	IN
cord-301755-fxfsr9bj	163	34	AGT	AGT	NNP
cord-301755-fxfsr9bj	163	35	(	(	-LRB-
cord-301755-fxfsr9bj	163	36	Ser	Ser	NNP
cord-301755-fxfsr9bj	163	37	)	)	-RRB-
cord-301755-fxfsr9bj	163	38	.	.	.
cord-301755-fxfsr9bj	164	1	Since	since	IN
cord-301755-fxfsr9bj	164	2	none	none	NN
cord-301755-fxfsr9bj	164	3	of	of	IN
cord-301755-fxfsr9bj	164	4	the	the	DT
cord-301755-fxfsr9bj	164	5	revertants	revertant	NNS
cord-301755-fxfsr9bj	164	6	completely	completely	RB
cord-301755-fxfsr9bj	164	7	restored	restore	VBD
cord-301755-fxfsr9bj	164	8	the	the	DT
cord-301755-fxfsr9bj	164	9	phenotype	phenotype	NN
cord-301755-fxfsr9bj	164	10	to	to	IN
cord-301755-fxfsr9bj	164	11	that	that	DT
cord-301755-fxfsr9bj	164	12	of	of	IN
cord-301755-fxfsr9bj	164	13	the	the	DT
cord-301755-fxfsr9bj	164	14	parental	parental	JJ
cord-301755-fxfsr9bj	164	15	JHM	JHM	NNP
cord-301755-fxfsr9bj	164	16	-	-	HYPH
cord-301755-fxfsr9bj	164	17	DL	DL	NNP
cord-301755-fxfsr9bj	164	18	,	,	,
cord-301755-fxfsr9bj	164	19	the	the	DT
cord-301755-fxfsr9bj	164	20	most	most	RBS
cord-301755-fxfsr9bj	164	21	logical	logical	JJ
cord-301755-fxfsr9bj	164	22	explanation	explanation	NN
cord-301755-fxfsr9bj	164	23	was	be	VBD
cord-301755-fxfsr9bj	164	24	that	that	IN
cord-301755-fxfsr9bj	164	25	different	different	JJ
cord-301755-fxfsr9bj	164	26	regions	region	NNS
cord-301755-fxfsr9bj	164	27	of	of	IN
cord-301755-fxfsr9bj	164	28	the	the	DT
cord-301755-fxfsr9bj	164	29	S	S	NNP
cord-301755-fxfsr9bj	164	30	protein	protein	NN
cord-301755-fxfsr9bj	164	31	may	may	MD
cord-301755-fxfsr9bj	164	32	cooperate	cooperate	VB
cord-301755-fxfsr9bj	164	33	to	to	TO
cord-301755-fxfsr9bj	164	34	contribute	contribute	VB
cord-301755-fxfsr9bj	164	35	to	to	IN
cord-301755-fxfsr9bj	164	36	the	the	DT
cord-301755-fxfsr9bj	164	37	resistance	resistance	NN
cord-301755-fxfsr9bj	164	38	of	of	IN
cord-301755-fxfsr9bj	164	39	the	the	DT
cord-301755-fxfsr9bj	164	40	virus	virus	NN
cord-301755-fxfsr9bj	164	41	to	to	IN
cord-301755-fxfsr9bj	164	42	neutralization	neutralization	NN
cord-301755-fxfsr9bj	164	43	by	by	IN
cord-301755-fxfsr9bj	164	44	MAb	MAb	NNPS
cord-301755-fxfsr9bj	164	45	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	164	46	.	.	.
cord-301755-fxfsr9bj	165	1	The	the	DT
cord-301755-fxfsr9bj	165	2	finding	finding	NN
cord-301755-fxfsr9bj	165	3	that	that	IN
cord-301755-fxfsr9bj	165	4	NT	NT	NNP
cord-301755-fxfsr9bj	165	5	3340	3340	CD
cord-301755-fxfsr9bj	165	6	mutation	mutation	NN
cord-301755-fxfsr9bj	165	7	was	be	VBD
cord-301755-fxfsr9bj	165	8	retained	retain	VBN
cord-301755-fxfsr9bj	165	9	in	in	IN
cord-301755-fxfsr9bj	165	10	all	all	DT
cord-301755-fxfsr9bj	165	11	of	of	IN
cord-301755-fxfsr9bj	165	12	the	the	DT
cord-301755-fxfsr9bj	165	13	partial	partial	JJ
cord-301755-fxfsr9bj	165	14	revet	revet	NNS
cord-301755-fxfsr9bj	165	15	-	-	HYPH
cord-301755-fxfsr9bj	165	16	tants	tants	NNP
cord-301755-fxfsr9bj	165	17	suggested	suggest	VBD
cord-301755-fxfsr9bj	165	18	that	that	IN
cord-301755-fxfsr9bj	165	19	this	this	DT
cord-301755-fxfsr9bj	165	20	site	site	NN
cord-301755-fxfsr9bj	165	21	had	have	VBD
cord-301755-fxfsr9bj	165	22	a	a	DT
cord-301755-fxfsr9bj	165	23	major	major	JJ
cord-301755-fxfsr9bj	165	24	contribution	contribution	NN
cord-301755-fxfsr9bj	165	25	to	to	IN
cord-301755-fxfsr9bj	165	26	the	the	DT
cord-301755-fxfsr9bj	165	27	resistance	resistance	NN
cord-301755-fxfsr9bj	165	28	to	to	IN
cord-301755-fxfsr9bj	165	29	MAb	MAb	NNPS
cord-301755-fxfsr9bj	165	30	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	165	31	.	.	.
cord-301755-fxfsr9bj	166	1	Preliminary	preliminary	JJ
cord-301755-fxfsr9bj	166	2	viral	viral	JJ
cord-301755-fxfsr9bj	166	3	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	166	4	study	study	NN
cord-301755-fxfsr9bj	166	5	by	by	IN
cord-301755-fxfsr9bj	166	6	intracerebral	intracerebral	JJ
cord-301755-fxfsr9bj	166	7	inoculation	inoculation	NN
cord-301755-fxfsr9bj	166	8	in	in	IN
cord-301755-fxfsr9bj	166	9	mice	mouse	NNS
cord-301755-fxfsr9bj	166	10	revealed	reveal	VBD
cord-301755-fxfsr9bj	166	11	that	that	IN
cord-301755-fxfsr9bj	166	12	VlO	vlo	NN
cord-301755-fxfsr9bj	166	13	had	have	VBD
cord-301755-fxfsr9bj	166	14	an	an	DT
cord-301755-fxfsr9bj	166	15	LD	LD	NNP
cord-301755-fxfsr9bj	166	16	,	,	,
cord-301755-fxfsr9bj	166	17	,	,	,
cord-301755-fxfsr9bj	166	18	of	of	IN
cord-301755-fxfsr9bj	166	19	approximately	approximately	RB
cord-301755-fxfsr9bj	166	20	1	1	CD
cord-301755-fxfsr9bj	166	21	O3	o3	NN
cord-301755-fxfsr9bj	166	22	PFU	PFU	NNP
cord-301755-fxfsr9bj	166	23	,	,	,
cord-301755-fxfsr9bj	166	24	similar	similar	JJ
cord-301755-fxfsr9bj	166	25	to	to	IN
cord-301755-fxfsr9bj	166	26	that	that	DT
cord-301755-fxfsr9bj	166	27	of	of	IN
cord-301755-fxfsr9bj	166	28	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	166	29	,	,	,
cord-301755-fxfsr9bj	166	30	but	but	CC
cord-301755-fxfsr9bj	166	31	in	in	IN
cord-301755-fxfsr9bj	166	32	contrast	contrast	NN
cord-301755-fxfsr9bj	166	33	to	to	IN
cord-301755-fxfsr9bj	166	34	JHM	JHM	NNP
cord-301755-fxfsr9bj	166	35	-	-	HYPH
cord-301755-fxfsr9bj	166	36	DL	DL	NNP
cord-301755-fxfsr9bj	166	37	,	,	,
cord-301755-fxfsr9bj	166	38	which	which	WDT
cord-301755-fxfsr9bj	166	39	had	have	VBD
cord-301755-fxfsr9bj	166	40	an	an	DT
cord-301755-fxfsr9bj	166	41	LD	LD	NNP
cord-301755-fxfsr9bj	166	42	,	,	,
cord-301755-fxfsr9bj	166	43	,	,	,
cord-301755-fxfsr9bj	166	44	of	of	IN
cord-301755-fxfsr9bj	166	45	4	4	CD
cord-301755-fxfsr9bj	166	46	PFU	pfu	NN
cord-301755-fxfsr9bj	166	47	(	(	-LRB-
cord-301755-fxfsr9bj	166	48	Table	table	NN
cord-301755-fxfsr9bj	166	49	1	1	CD
cord-301755-fxfsr9bj	166	50	)	)	-RRB-
cord-301755-fxfsr9bj	166	51	(	(	-LRB-
cord-301755-fxfsr9bj	166	52	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	166	53	et	et	NNP
cord-301755-fxfsr9bj	166	54	a/.	a/.	NNP
cord-301755-fxfsr9bj	166	55	,	,	,
cord-301755-fxfsr9bj	166	56	1986	1986	CD
cord-301755-fxfsr9bj	166	57	)	)	-RRB-
cord-301755-fxfsr9bj	166	58	.	.	.
cord-301755-fxfsr9bj	167	1	Similar	similar	JJ
cord-301755-fxfsr9bj	167	2	to	to	IN
cord-301755-fxfsr9bj	167	3	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	167	4	,	,	,
cord-301755-fxfsr9bj	167	5	the	the	DT
cord-301755-fxfsr9bj	167	6	partially	partially	RB
cord-301755-fxfsr9bj	167	7	revertant	revertant	JJ
cord-301755-fxfsr9bj	167	8	virus	virus	NN
cord-301755-fxfsr9bj	167	9	primarily	primarily	RB
cord-301755-fxfsr9bj	167	10	caused	cause	VBD
cord-301755-fxfsr9bj	167	11	demyelination	demyelination	NN
cord-301755-fxfsr9bj	167	12	with	with	IN
cord-301755-fxfsr9bj	167	13	little	little	JJ
cord-301755-fxfsr9bj	167	14	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	167	15	.	.	.
cord-301755-fxfsr9bj	168	1	These	these	DT
cord-301755-fxfsr9bj	168	2	results	result	NNS
cord-301755-fxfsr9bj	168	3	suggested	suggest	VBD
cord-301755-fxfsr9bj	168	4	that	that	IN
cord-301755-fxfsr9bj	168	5	the	the	DT
cord-301755-fxfsr9bj	168	6	second	second	JJ
cord-301755-fxfsr9bj	168	7	site	site	NN
cord-301755-fxfsr9bj	168	8	mutation	mutation	NN
cord-301755-fxfsr9bj	168	9	in	in	IN
cord-301755-fxfsr9bj	168	10	the	the	DT
cord-301755-fxfsr9bj	168	11	Sl	Sl	NNP
cord-301755-fxfsr9bj	168	12	region	region	NN
cord-301755-fxfsr9bj	168	13	did	do	VBD
cord-301755-fxfsr9bj	168	14	not	not	RB
cord-301755-fxfsr9bj	168	15	alter	alter	VB
cord-301755-fxfsr9bj	168	16	the	the	DT
cord-301755-fxfsr9bj	168	17	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	168	18	of	of	IN
cord-301755-fxfsr9bj	168	19	the	the	DT
cord-301755-fxfsr9bj	168	20	virus	virus	NN
cord-301755-fxfsr9bj	168	21	and	and	CC
cord-301755-fxfsr9bj	168	22	that	that	IN
cord-301755-fxfsr9bj	168	23	the	the	DT
cord-301755-fxfsr9bj	168	24	mutation	mutation	NN
cord-301755-fxfsr9bj	168	25	at	at	IN
cord-301755-fxfsr9bj	168	26	NT	NT	NNP
cord-301755-fxfsr9bj	168	27	3340	3340	CD
cord-301755-fxfsr9bj	168	28	was	be	VBD
cord-301755-fxfsr9bj	168	29	most	most	RBS
cord-301755-fxfsr9bj	168	30	responsible	responsible	JJ
cord-301755-fxfsr9bj	168	31	for	for	IN
cord-301755-fxfsr9bj	168	32	the	the	DT
cord-301755-fxfsr9bj	168	33	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	168	34	of	of	IN
cord-301755-fxfsr9bj	168	35	the	the	DT
cord-301755-fxfsr9bj	168	36	JHM	JHM	NNP
cord-301755-fxfsr9bj	168	37	viruses	virus	NNS
cord-301755-fxfsr9bj	168	38	.	.	.
cord-301755-fxfsr9bj	169	1	Our	-PRON-	PRP$
cord-301755-fxfsr9bj	169	2	sequence	sequence	NN
cord-301755-fxfsr9bj	169	3	analysis	analysis	NN
cord-301755-fxfsr9bj	169	4	of	of	IN
cord-301755-fxfsr9bj	169	5	MAb	MAb	NNS
cord-301755-fxfsr9bj	169	6	-	-	HYPH
cord-301755-fxfsr9bj	169	7	escape	escape	NN
cord-301755-fxfsr9bj	169	8	mutants	mutant	NNS
cord-301755-fxfsr9bj	169	9	of	of	IN
cord-301755-fxfsr9bj	169	10	JHM	JHM	NNP
cord-301755-fxfsr9bj	169	11	indicated	indicate	VBD
cord-301755-fxfsr9bj	169	12	that	that	IN
cord-301755-fxfsr9bj	169	13	a	a	DT
cord-301755-fxfsr9bj	169	14	mutant	mutant	JJ
cord-301755-fxfsr9bj	169	15	selected	select	VBN
cord-301755-fxfsr9bj	169	16	with	with	IN
cord-301755-fxfsr9bj	169	17	MAb	MAb	NNPS
cord-301755-fxfsr9bj	169	18	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	169	19	had	have	VBD
cord-301755-fxfsr9bj	169	20	a	a	DT
cord-301755-fxfsr9bj	169	21	point	point	NN
cord-301755-fxfsr9bj	169	22	mutation	mutation	NN
cord-301755-fxfsr9bj	169	23	in	in	IN
cord-301755-fxfsr9bj	169	24	the	the	DT
cord-301755-fxfsr9bj	169	25	S2	S2	NNP
cord-301755-fxfsr9bj	169	26	region	region	NN
cord-301755-fxfsr9bj	169	27	of	of	IN
cord-301755-fxfsr9bj	169	28	the	the	DT
cord-301755-fxfsr9bj	169	29	spike	spike	NN
cord-301755-fxfsr9bj	169	30	protein	protein	NN
cord-301755-fxfsr9bj	169	31	.	.	.
cord-301755-fxfsr9bj	170	1	By	by	IN
cord-301755-fxfsr9bj	170	2	contrast	contrast	NN
cord-301755-fxfsr9bj	170	3	,	,	,
cord-301755-fxfsr9bj	170	4	when	when	WRB
cord-301755-fxfsr9bj	170	5	MAb	MAb	NNS
cord-301755-fxfsr9bj	170	6	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	170	7	was	be	VBD
cord-301755-fxfsr9bj	170	8	used	use	VBN
cord-301755-fxfsr9bj	170	9	to	to	TO
cord-301755-fxfsr9bj	170	10	select	select	VB
cord-301755-fxfsr9bj	170	11	mutants	mutant	NNS
cord-301755-fxfsr9bj	170	12	,	,	,
cord-301755-fxfsr9bj	170	13	point	point	NN
cord-301755-fxfsr9bj	170	14	mutations	mutation	NNS
cord-301755-fxfsr9bj	170	15	or	or	CC
cord-301755-fxfsr9bj	170	16	a	a	DT
cord-301755-fxfsr9bj	170	17	deletion	deletion	NN
cord-301755-fxfsr9bj	170	18	in	in	IN
cord-301755-fxfsr9bj	170	19	Sl	sl	NN
cord-301755-fxfsr9bj	170	20	within	within	IN
cord-301755-fxfsr9bj	170	21	NT	NT	NNP
cord-301755-fxfsr9bj	171	1	1500-l	1500-l	LS
cord-301755-fxfsr9bj	171	2	950	950	CD
cord-301755-fxfsr9bj	171	3	were	be	VBD
cord-301755-fxfsr9bj	171	4	observed	observe	VBN
cord-301755-fxfsr9bj	171	5	.	.	.
cord-301755-fxfsr9bj	172	1	Previous	previous	JJ
cord-301755-fxfsr9bj	172	2	attempts	attempt	NNS
cord-301755-fxfsr9bj	172	3	at	at	IN
cord-301755-fxfsr9bj	172	4	mapping	map	VBG
cord-301755-fxfsr9bj	172	5	the	the	DT
cord-301755-fxfsr9bj	172	6	binding	bind	VBG
cord-301755-fxfsr9bj	172	7	sites	site	NNS
cord-301755-fxfsr9bj	172	8	of	of	IN
cord-301755-fxfsr9bj	172	9	these	these	DT
cord-301755-fxfsr9bj	172	10	MAbs	MAbs	NNP
cord-301755-fxfsr9bj	172	11	have	have	VBP
cord-301755-fxfsr9bj	172	12	failed	fail	VBN
cord-301755-fxfsr9bj	172	13	(	(	-LRB-
cord-301755-fxfsr9bj	172	14	Weismiller	Weismiller	NNP
cord-301755-fxfsr9bj	172	15	eta/.	eta/.	CD
cord-301755-fxfsr9bj	172	16	,	,	,
cord-301755-fxfsr9bj	172	17	1990	1990	CD
cord-301755-fxfsr9bj	172	18	)	)	-RRB-
cord-301755-fxfsr9bj	172	19	.	.	.
cord-301755-fxfsr9bj	173	1	Our	-PRON-	PRP$
cord-301755-fxfsr9bj	173	2	study	study	NN
cord-301755-fxfsr9bj	173	3	suggested	suggest	VBD
cord-301755-fxfsr9bj	173	4	that	that	IN
cord-301755-fxfsr9bj	173	5	MAb	MAb	NNS
cord-301755-fxfsr9bj	173	6	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	173	7	would	would	MD
cord-301755-fxfsr9bj	173	8	bind	bind	VB
cord-301755-fxfsr9bj	173	9	to	to	IN
cord-301755-fxfsr9bj	173	10	Sl	Sl	NNS
cord-301755-fxfsr9bj	173	11	while	while	IN
cord-301755-fxfsr9bj	173	12	MAb	MAb	NNS
cord-301755-fxfsr9bj	173	13	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	173	14	would	would	MD
cord-301755-fxfsr9bj	173	15	bind	bind	VB
cord-301755-fxfsr9bj	173	16	to	to	IN
cord-301755-fxfsr9bj	173	17	S2	S2	NNP
cord-301755-fxfsr9bj	173	18	.	.	.
cord-301755-fxfsr9bj	174	1	These	these	DT
cord-301755-fxfsr9bj	174	2	findings	finding	NNS
cord-301755-fxfsr9bj	174	3	are	be	VBP
cord-301755-fxfsr9bj	174	4	consistent	consistent	JJ
cord-301755-fxfsr9bj	174	5	with	with	IN
cord-301755-fxfsr9bj	174	6	a	a	DT
cord-301755-fxfsr9bj	174	7	recent	recent	JJ
cord-301755-fxfsr9bj	174	8	study	study	NN
cord-301755-fxfsr9bj	174	9	measuring	measure	VBG
cord-301755-fxfsr9bj	174	10	the	the	DT
cord-301755-fxfsr9bj	174	11	direct	direct	JJ
cord-301755-fxfsr9bj	174	12	binding	binding	NN
cord-301755-fxfsr9bj	174	13	of	of	IN
cord-301755-fxfsr9bj	174	14	the	the	DT
cord-301755-fxfsr9bj	174	15	MHV	mhv	NN
cord-301755-fxfsr9bj	174	16	-	-	HYPH
cord-301755-fxfsr9bj	174	17	specific	specific	JJ
cord-301755-fxfsr9bj	174	18	MAb	MAb	NNS
cord-301755-fxfsr9bj	174	19	,	,	,
cord-301755-fxfsr9bj	174	20	which	which	WDT
cord-301755-fxfsr9bj	174	21	also	also	RB
cord-301755-fxfsr9bj	174	22	indicated	indicate	VBD
cord-301755-fxfsr9bj	174	23	that	that	IN
cord-301755-fxfsr9bj	174	24	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	174	25	bound	bind	VBN
cord-301755-fxfsr9bj	174	26	to	to	IN
cord-301755-fxfsr9bj	174	27	S2	s2	NN
cord-301755-fxfsr9bj	174	28	(	(	-LRB-
cord-301755-fxfsr9bj	174	29	P.	P.	NNP
cord-301755-fxfsr9bj	174	30	Talbot	Talbot	NNP
cord-301755-fxfsr9bj	174	31	,	,	,
cord-301755-fxfsr9bj	174	32	personal	personal	JJ
cord-301755-fxfsr9bj	174	33	communication	communication	NN
cord-301755-fxfsr9bj	174	34	)	)	-RRB-
cord-301755-fxfsr9bj	174	35	.	.	.
cord-301755-fxfsr9bj	175	1	The	the	DT
cord-301755-fxfsr9bj	175	2	binding	binding	NN
cord-301755-fxfsr9bj	175	3	site	site	NN
cord-301755-fxfsr9bj	175	4	of	of	IN
cord-301755-fxfsr9bj	175	5	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	175	6	is	be	VBZ
cord-301755-fxfsr9bj	175	7	close	close	JJ
cord-301755-fxfsr9bj	175	8	to	to	IN
cord-301755-fxfsr9bj	175	9	other	other	JJ
cord-301755-fxfsr9bj	175	10	52	52	CD
cord-301755-fxfsr9bj	175	11	neutralizing	neutralize	VBG
cord-301755-fxfsr9bj	175	12	epitopes	epitope	NNS
cord-301755-fxfsr9bj	175	13	identified	identify	VBN
cord-301755-fxfsr9bj	175	14	in	in	IN
cord-301755-fxfsr9bj	175	15	other	other	JJ
cord-301755-fxfsr9bj	175	16	laboratories	laboratory	NNS
cord-301755-fxfsr9bj	175	17	(	(	-LRB-
cord-301755-fxfsr9bj	175	18	Luytjes	Luytjes	NNP
cord-301755-fxfsr9bj	175	19	et	et	NNP
cord-301755-fxfsr9bj	175	20	al	al	NNP
cord-301755-fxfsr9bj	175	21	.	.	.
cord-301755-fxfsr9bj	176	1	,	,	,
cord-301755-fxfsr9bj	176	2	1989	1989	CD
cord-301755-fxfsr9bj	176	3	;	;	:
cord-301755-fxfsr9bj	176	4	Routledge	Routledge	NNP
cord-301755-fxfsr9bj	176	5	et	et	NNP
cord-301755-fxfsr9bj	176	6	al	al	NNP
cord-301755-fxfsr9bj	176	7	.	.	NNP
cord-301755-fxfsr9bj	176	8	,	,	,
cord-301755-fxfsr9bj	176	9	1991	1991	CD
cord-301755-fxfsr9bj	176	10	)	)	-RRB-
cord-301755-fxfsr9bj	176	11	.	.	.
cord-301755-fxfsr9bj	177	1	Interestingly	interestingly	RB
cord-301755-fxfsr9bj	177	2	,	,	,
cord-301755-fxfsr9bj	177	3	the	the	DT
cord-301755-fxfsr9bj	177	4	mutation	mutation	NN
cord-301755-fxfsr9bj	177	5	at	at	IN
cord-301755-fxfsr9bj	177	6	NT	NT	NNP
cord-301755-fxfsr9bj	177	7	3340	3340	CD
cord-301755-fxfsr9bj	177	8	,	,	,
cord-301755-fxfsr9bj	177	9	which	which	WDT
cord-301755-fxfsr9bj	177	10	changed	change	VBD
cord-301755-fxfsr9bj	177	11	the	the	DT
cord-301755-fxfsr9bj	177	12	coded	code	VBN
cord-301755-fxfsr9bj	177	13	amino	amino	NN
cord-301755-fxfsr9bj	177	14	acid	acid	NN
cord-301755-fxfsr9bj	177	15	from	from	IN
cord-301755-fxfsr9bj	177	16	leu	leu	NNP
cord-301755-fxfsr9bj	177	17	to	to	IN
cord-301755-fxfsr9bj	177	18	phe	phe	NNP
cord-301755-fxfsr9bj	177	19	affected	affect	VBD
cord-301755-fxfsr9bj	177	20	one	one	CD
cord-301755-fxfsr9bj	177	21	of	of	IN
cord-301755-fxfsr9bj	177	22	the	the	DT
cord-301755-fxfsr9bj	177	23	three	three	CD
cord-301755-fxfsr9bj	177	24	amino	amino	NN
cord-301755-fxfsr9bj	177	25	acids	acid	NNS
cord-301755-fxfsr9bj	177	26	which	which	WDT
cord-301755-fxfsr9bj	177	27	are	be	VBP
cord-301755-fxfsr9bj	177	28	critical	critical	JJ
cord-301755-fxfsr9bj	177	29	for	for	IN
cord-301755-fxfsr9bj	177	30	the	the	DT
cord-301755-fxfsr9bj	177	31	fusion	fusion	NN
cord-301755-fxfsr9bj	177	32	function	function	NN
cord-301755-fxfsr9bj	177	33	of	of	IN
cord-301755-fxfsr9bj	177	34	the	the	DT
cord-301755-fxfsr9bj	177	35	S	S	NNP
cord-301755-fxfsr9bj	177	36	protein	protein	NN
cord-301755-fxfsr9bj	177	37	(	(	-LRB-
cord-301755-fxfsr9bj	177	38	Gallagher	Gallagher	NNP
cord-301755-fxfsr9bj	177	39	et	et	NNP
cord-301755-fxfsr9bj	177	40	al	al	NNP
cord-301755-fxfsr9bj	177	41	.	.	NNP
cord-301755-fxfsr9bj	177	42	,	,	,
cord-301755-fxfsr9bj	177	43	1991	1991	CD
cord-301755-fxfsr9bj	177	44	)	)	-RRB-
cord-301755-fxfsr9bj	177	45	.	.	.
cord-301755-fxfsr9bj	178	1	However	however	RB
cord-301755-fxfsr9bj	178	2	,	,	,
cord-301755-fxfsr9bj	178	3	the	the	DT
cord-301755-fxfsr9bj	178	4	variant	variant	JJ
cord-301755-fxfsr9bj	178	5	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	178	6	-	-	HYPH
cord-301755-fxfsr9bj	178	7	l	l	NN
cord-301755-fxfsr9bj	178	8	induced	induce	VBN
cord-301755-fxfsr9bj	178	9	fusion	fusion	NN
cord-301755-fxfsr9bj	178	10	when	when	WRB
cord-301755-fxfsr9bj	178	11	grown	grow	VBN
cord-301755-fxfsr9bj	178	12	on	on	IN
cord-301755-fxfsr9bj	178	13	DBT	DBT	NNP
cord-301755-fxfsr9bj	178	14	cells	cell	NNS
cord-301755-fxfsr9bj	178	15	(	(	-LRB-
cord-301755-fxfsr9bj	178	16	data	datum	NNS
cord-301755-fxfsr9bj	178	17	not	not	RB
cord-301755-fxfsr9bj	178	18	shown	show	VBN
cord-301755-fxfsr9bj	178	19	)	)	-RRB-
cord-301755-fxfsr9bj	178	20	;	;	:
cord-301755-fxfsr9bj	178	21	this	this	DT
cord-301755-fxfsr9bj	178	22	was	be	VBD
cord-301755-fxfsr9bj	178	23	expected	expect	VBN
cord-301755-fxfsr9bj	178	24	since	since	IN
cord-301755-fxfsr9bj	178	25	the	the	DT
cord-301755-fxfsr9bj	178	26	loss	loss	NN
cord-301755-fxfsr9bj	178	27	of	of	IN
cord-301755-fxfsr9bj	178	28	the	the	DT
cord-301755-fxfsr9bj	178	29	fusion	fusion	NN
cord-301755-fxfsr9bj	178	30	activity	activity	NN
cord-301755-fxfsr9bj	178	31	required	require	VBD
cord-301755-fxfsr9bj	178	32	the	the	DT
cord-301755-fxfsr9bj	178	33	simultaneous	simultaneous	JJ
cord-301755-fxfsr9bj	178	34	mutations	mutation	NNS
cord-301755-fxfsr9bj	178	35	of	of	IN
cord-301755-fxfsr9bj	178	36	all	all	PDT
cord-301755-fxfsr9bj	178	37	the	the	DT
cord-301755-fxfsr9bj	178	38	three	three	CD
cord-301755-fxfsr9bj	178	39	amino	amino	NN
cord-301755-fxfsr9bj	178	40	acids	acid	NNS
cord-301755-fxfsr9bj	178	41	(	(	-LRB-
cord-301755-fxfsr9bj	178	42	Gallagher	Gallagher	NNP
cord-301755-fxfsr9bj	178	43	er	er	UH
cord-301755-fxfsr9bj	178	44	al	al	NNP
cord-301755-fxfsr9bj	178	45	.	.	NNP
cord-301755-fxfsr9bj	178	46	,	,	,
cord-301755-fxfsr9bj	178	47	199	199	CD
cord-301755-fxfsr9bj	178	48	1	1	CD
cord-301755-fxfsr9bj	178	49	)	)	-RRB-
cord-301755-fxfsr9bj	178	50	.	.	.
cord-301755-fxfsr9bj	179	1	Nevertheless	nevertheless	RB
cord-301755-fxfsr9bj	179	2	,	,	,
cord-301755-fxfsr9bj	179	3	these	these	DT
cord-301755-fxfsr9bj	179	4	findings	finding	NNS
cord-301755-fxfsr9bj	179	5	show	show	VBP
cord-301755-fxfsr9bj	179	6	that	that	IN
cord-301755-fxfsr9bj	179	7	this	this	DT
cord-301755-fxfsr9bj	179	8	amino	amino	NN
cord-301755-fxfsr9bj	179	9	acid	acid	NN
cord-301755-fxfsr9bj	179	10	plays	play	VBZ
cord-301755-fxfsr9bj	179	11	an	an	DT
cord-301755-fxfsr9bj	179	12	important	important	JJ
cord-301755-fxfsr9bj	179	13	role	role	NN
cord-301755-fxfsr9bj	179	14	in	in	IN
cord-301755-fxfsr9bj	179	15	both	both	DT
cord-301755-fxfsr9bj	179	16	fusion	fusion	NN
cord-301755-fxfsr9bj	179	17	activity	activity	NN
cord-301755-fxfsr9bj	179	18	and	and	CC
cord-301755-fxfsr9bj	179	19	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	179	20	of	of	IN
cord-301755-fxfsr9bj	179	21	MHV	MHV	NNP
cord-301755-fxfsr9bj	179	22	.	.	.
cord-301755-fxfsr9bj	180	1	The	the	DT
cord-301755-fxfsr9bj	180	2	region	region	NN
cord-301755-fxfsr9bj	180	3	of	of	IN
cord-301755-fxfsr9bj	180	4	Sl	Sl	NNP
cord-301755-fxfsr9bj	180	5	with	with	IN
cord-301755-fxfsr9bj	180	6	deletion	deletion	NN
cord-301755-fxfsr9bj	180	7	or	or	CC
cord-301755-fxfsr9bj	180	8	point	point	NN
cord-301755-fxfsr9bj	180	9	mutations	mutation	NNS
cord-301755-fxfsr9bj	180	10	in	in	IN
cord-301755-fxfsr9bj	180	11	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	180	12	or	or	CC
cord-301755-fxfsr9bj	180	13	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	180	14	-	-	HYPH
cord-301755-fxfsr9bj	180	15	l	l	NN
cord-301755-fxfsr9bj	180	16	mutants	mutant	NNS
cord-301755-fxfsr9bj	180	17	corresponds	correspond	VBZ
cord-301755-fxfsr9bj	180	18	to	to	IN
cord-301755-fxfsr9bj	180	19	a	a	DT
cord-301755-fxfsr9bj	180	20	previously	previously	RB
cord-301755-fxfsr9bj	180	21	identified	identify	VBN
cord-301755-fxfsr9bj	180	22	hypervariable	hypervariable	JJ
cord-301755-fxfsr9bj	180	23	site	site	NN
cord-301755-fxfsr9bj	180	24	on	on	IN
cord-301755-fxfsr9bj	180	25	Sl	Sl	NNP
cord-301755-fxfsr9bj	180	26	(	(	-LRB-
cord-301755-fxfsr9bj	180	27	Parker	Parker	NNP
cord-301755-fxfsr9bj	180	28	et	et	NNP
cord-301755-fxfsr9bj	180	29	a/.	a/.	NNP
cord-301755-fxfsr9bj	180	30	,	,	,
cord-301755-fxfsr9bj	180	31	1989	1989	CD
cord-301755-fxfsr9bj	180	32	;	;	:
cord-301755-fxfsr9bj	180	33	Banner	Banner	NNP
cord-301755-fxfsr9bj	180	34	et	et	NNP
cord-301755-fxfsr9bj	180	35	a/.	a/.	NNP
cord-301755-fxfsr9bj	180	36	,	,	,
cord-301755-fxfsr9bj	180	37	1990	1990	CD
cord-301755-fxfsr9bj	180	38	)	)	-RRB-
cord-301755-fxfsr9bj	180	39	.	.	.
cord-301755-fxfsr9bj	181	1	This	this	DT
cord-301755-fxfsr9bj	181	2	site	site	NN
cord-301755-fxfsr9bj	181	3	underwent	undergo	VBD
cord-301755-fxfsr9bj	181	4	frequent	frequent	JJ
cord-301755-fxfsr9bj	181	5	deletions	deletion	NNS
cord-301755-fxfsr9bj	181	6	or	or	CC
cord-301755-fxfsr9bj	181	7	point	point	NN
cord-301755-fxfsr9bj	181	8	mutations	mutation	NNS
cord-301755-fxfsr9bj	181	9	upon	upon	IN
cord-301755-fxfsr9bj	181	10	viral	viral	JJ
cord-301755-fxfsr9bj	181	11	passages	passage	NNS
cord-301755-fxfsr9bj	181	12	in	in	IN
cord-301755-fxfsr9bj	181	13	tissue	tissue	NN
cord-301755-fxfsr9bj	181	14	culture	culture	NN
cord-301755-fxfsr9bj	181	15	or	or	CC
cord-301755-fxfsr9bj	181	16	animals	animal	NNS
cord-301755-fxfsr9bj	181	17	(	(	-LRB-
cord-301755-fxfsr9bj	181	18	Dalziel	Dalziel	NNP
cord-301755-fxfsr9bj	181	19	eta/.	eta/.	CD
cord-301755-fxfsr9bj	181	20	,	,	,
cord-301755-fxfsr9bj	181	21	1986	1986	CD
cord-301755-fxfsr9bj	181	22	;	;	:
cord-301755-fxfsr9bj	181	23	Banner	Banner	NNP
cord-301755-fxfsr9bj	181	24	et	et	NNP
cord-301755-fxfsr9bj	181	25	a/.	a/.	NNP
cord-301755-fxfsr9bj	181	26	,	,	,
cord-301755-fxfsr9bj	181	27	1990	1990	CD
cord-301755-fxfsr9bj	181	28	;	;	:
cord-301755-fxfsr9bj	181	29	Gallagher	Gallagher	NNP
cord-301755-fxfsr9bj	181	30	et	et	NNP
cord-301755-fxfsr9bj	181	31	a/.	a/.	NNP
cord-301755-fxfsr9bj	181	32	,	,	,
cord-301755-fxfsr9bj	181	33	1990	1990	CD
cord-301755-fxfsr9bj	181	34	)	)	-RRB-
cord-301755-fxfsr9bj	181	35	.	.	.
cord-301755-fxfsr9bj	182	1	Although	although	IN
cord-301755-fxfsr9bj	182	2	the	the	DT
cord-301755-fxfsr9bj	182	3	precise	precise	JJ
cord-301755-fxfsr9bj	182	4	sites	site	NNS
cord-301755-fxfsr9bj	182	5	of	of	IN
cord-301755-fxfsr9bj	182	6	deletion	deletion	NN
cord-301755-fxfsr9bj	182	7	or	or	CC
cord-301755-fxfsr9bj	182	8	point	point	NN
cord-301755-fxfsr9bj	182	9	mutations	mutation	NNS
cord-301755-fxfsr9bj	182	10	were	be	VBD
cord-301755-fxfsr9bj	182	11	different	different	JJ
cord-301755-fxfsr9bj	182	12	among	among	IN
cord-301755-fxfsr9bj	182	13	these	these	DT
cord-301755-fxfsr9bj	182	14	variants	variant	NNS
cord-301755-fxfsr9bj	182	15	,	,	,
cord-301755-fxfsr9bj	182	16	they	-PRON-	PRP
cord-301755-fxfsr9bj	182	17	were	be	VBD
cord-301755-fxfsr9bj	182	18	in	in	IN
cord-301755-fxfsr9bj	182	19	the	the	DT
cord-301755-fxfsr9bj	182	20	same	same	JJ
cord-301755-fxfsr9bj	182	21	general	general	JJ
cord-301755-fxfsr9bj	182	22	area	area	NN
cord-301755-fxfsr9bj	182	23	,	,	,
cord-301755-fxfsr9bj	182	24	i.e.	i.e.	FW
cord-301755-fxfsr9bj	182	25	,	,	,
cord-301755-fxfsr9bj	182	26	near	near	IN
cord-301755-fxfsr9bj	182	27	the	the	DT
cord-301755-fxfsr9bj	182	28	C	c	NN
cord-301755-fxfsr9bj	182	29	-	-	HYPH
cord-301755-fxfsr9bj	182	30	terminus	terminus	NN
cord-301755-fxfsr9bj	182	31	of	of	IN
cord-301755-fxfsr9bj	183	1	Sl	Sl	NNP
cord-301755-fxfsr9bj	183	2	Previously	previously	RB
cord-301755-fxfsr9bj	183	3	,	,	,
cord-301755-fxfsr9bj	183	4	Buchmeier	Buchmeier	NNP
cord-301755-fxfsr9bj	183	5	's	's	POS
cord-301755-fxfsr9bj	183	6	laboratory	laboratory	NN
cord-301755-fxfsr9bj	183	7	also	also	RB
cord-301755-fxfsr9bj	183	8	has	have	VBZ
cord-301755-fxfsr9bj	183	9	reported	report	VBN
cord-301755-fxfsr9bj	183	10	different	different	JJ
cord-301755-fxfsr9bj	183	11	types	type	NNS
cord-301755-fxfsr9bj	183	12	of	of	IN
cord-301755-fxfsr9bj	183	13	mutation	mutation	NN
cord-301755-fxfsr9bj	183	14	among	among	IN
cord-301755-fxfsr9bj	183	15	the	the	DT
cord-301755-fxfsr9bj	183	16	neutralization	neutralization	NN
cord-301755-fxfsr9bj	183	17	-	-	HYPH
cord-301755-fxfsr9bj	183	18	escape	escape	NN
cord-301755-fxfsr9bj	183	19	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	183	20	variants	variant	NNS
cord-301755-fxfsr9bj	183	21	,	,	,
cord-301755-fxfsr9bj	183	22	which	which	WDT
cord-301755-fxfsr9bj	183	23	were	be	VBD
cord-301755-fxfsr9bj	183	24	derived	derive	VBN
cord-301755-fxfsr9bj	183	25	by	by	IN
cord-301755-fxfsr9bj	183	26	use	use	NN
cord-301755-fxfsr9bj	183	27	of	of	IN
cord-301755-fxfsr9bj	183	28	a	a	DT
cord-301755-fxfsr9bj	183	29	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	183	30	antibody	antibody	NN
cord-301755-fxfsr9bj	183	31	different	different	JJ
cord-301755-fxfsr9bj	183	32	from	from	IN
cord-301755-fxfsr9bj	183	33	the	the	DT
cord-301755-fxfsr9bj	183	34	one	one	NN
cord-301755-fxfsr9bj	183	35	used	use	VBN
cord-301755-fxfsr9bj	183	36	in	in	IN
cord-301755-fxfsr9bj	183	37	our	-PRON-	PRP$
cord-301755-fxfsr9bj	183	38	study	study	NN
cord-301755-fxfsr9bj	183	39	(	(	-LRB-
cord-301755-fxfsr9bj	183	40	Parker	Parker	NNP
cord-301755-fxfsr9bj	183	41	er	er	UH
cord-301755-fxfsr9bj	183	42	a/.	a/.	NNP
cord-301755-fxfsr9bj	183	43	,	,	,
cord-301755-fxfsr9bj	183	44	1989	1989	CD
cord-301755-fxfsr9bj	183	45	;	;	:
cord-301755-fxfsr9bj	183	46	Gallagher	Gallagher	NNP
cord-301755-fxfsr9bj	183	47	et	et	NNP
cord-301755-fxfsr9bj	183	48	al	al	NNP
cord-301755-fxfsr9bj	183	49	.	.	NNP
cord-301755-fxfsr9bj	183	50	,	,	,
cord-301755-fxfsr9bj	183	51	1990	1990	CD
cord-301755-fxfsr9bj	183	52	)	)	-RRB-
cord-301755-fxfsr9bj	183	53	.	.	.
cord-301755-fxfsr9bj	184	1	All	all	DT
cord-301755-fxfsr9bj	184	2	of	of	IN
cord-301755-fxfsr9bj	184	3	these	these	DT
cord-301755-fxfsr9bj	184	4	variants	variant	NNS
cord-301755-fxfsr9bj	184	5	have	have	VBP
cord-301755-fxfsr9bj	184	6	either	either	CC
cord-301755-fxfsr9bj	184	7	deletion	deletion	NN
cord-301755-fxfsr9bj	184	8	or	or	CC
cord-301755-fxfsr9bj	184	9	point	point	NN
cord-301755-fxfsr9bj	184	10	mutations	mutation	NNS
cord-301755-fxfsr9bj	184	11	in	in	IN
cord-301755-fxfsr9bj	184	12	this	this	DT
cord-301755-fxfsr9bj	184	13	area	area	NN
cord-301755-fxfsr9bj	184	14	of	of	IN
cord-301755-fxfsr9bj	184	15	Sl	sl	NN
cord-301755-fxfsr9bj	185	1	These	these	DT
cord-301755-fxfsr9bj	185	2	results	result	NNS
cord-301755-fxfsr9bj	185	3	together	together	RB
cord-301755-fxfsr9bj	185	4	suggested	suggest	VBD
cord-301755-fxfsr9bj	185	5	that	that	IN
cord-301755-fxfsr9bj	185	6	this	this	DT
cord-301755-fxfsr9bj	185	7	region	region	NN
cord-301755-fxfsr9bj	185	8	represented	represent	VBD
cord-301755-fxfsr9bj	185	9	an	an	DT
cord-301755-fxfsr9bj	185	10	immunodominant	immunodominant	JJ
cord-301755-fxfsr9bj	185	11	and	and	CC
cord-301755-fxfsr9bj	185	12	highly	highly	RB
cord-301755-fxfsr9bj	185	13	variable	variable	JJ
cord-301755-fxfsr9bj	185	14	site	site	NN
cord-301755-fxfsr9bj	185	15	,	,	,
cord-301755-fxfsr9bj	185	16	although	although	IN
cord-301755-fxfsr9bj	185	17	the	the	DT
cord-301755-fxfsr9bj	185	18	binding	binding	NN
cord-301755-fxfsr9bj	185	19	site	site	NN
cord-301755-fxfsr9bj	185	20	of	of	IN
cord-301755-fxfsr9bj	185	21	MAb	MAb	NNPS
cord-301755-fxfsr9bj	185	22	J.7.2	J.7.2	NNP
cord-301755-fxfsr9bj	185	23	has	have	VBZ
cord-301755-fxfsr9bj	185	24	not	not	RB
cord-301755-fxfsr9bj	185	25	been	be	VBN
cord-301755-fxfsr9bj	185	26	directly	directly	RB
cord-301755-fxfsr9bj	185	27	determined	determine	VBN
cord-301755-fxfsr9bj	185	28	.	.	.
cord-301755-fxfsr9bj	186	1	Taken	take	VBN
cord-301755-fxfsr9bj	186	2	together	together	RB
cord-301755-fxfsr9bj	186	3	with	with	IN
cord-301755-fxfsr9bj	186	4	previous	previous	JJ
cord-301755-fxfsr9bj	186	5	studies	study	NNS
cord-301755-fxfsr9bj	186	6	,	,	,
cord-301755-fxfsr9bj	186	7	our	-PRON-	PRP$
cord-301755-fxfsr9bj	186	8	analysis	analysis	NN
cord-301755-fxfsr9bj	186	9	indicates	indicate	VBZ
cord-301755-fxfsr9bj	186	10	that	that	IN
cord-301755-fxfsr9bj	186	11	at	at	RB
cord-301755-fxfsr9bj	186	12	least	least	RBS
cord-301755-fxfsr9bj	186	13	two	two	CD
cord-301755-fxfsr9bj	186	14	sites	site	NNS
cord-301755-fxfsr9bj	186	15	on	on	IN
cord-301755-fxfsr9bj	186	16	S	S	NNP
cord-301755-fxfsr9bj	186	17	play	play	VBP
cord-301755-fxfsr9bj	186	18	critical	critical	JJ
cord-301755-fxfsr9bj	186	19	roles	role	NNS
cord-301755-fxfsr9bj	186	20	in	in	IN
cord-301755-fxfsr9bj	186	21	MHV	MHV	NNP
cord-301755-fxfsr9bj	186	22	neuropathogenesis	neuropathogenesis	JJ
cord-301755-fxfsr9bj	186	23	:	:	:
cord-301755-fxfsr9bj	186	24	(	(	-LRB-
cord-301755-fxfsr9bj	186	25	1	1	LS
cord-301755-fxfsr9bj	186	26	)	)	-RRB-
cord-301755-fxfsr9bj	186	27	the	the	DT
cord-301755-fxfsr9bj	186	28	hypervariable	hypervariable	JJ
cord-301755-fxfsr9bj	186	29	Sl	Sl	NNP
cord-301755-fxfsr9bj	186	30	region	region	NN
cord-301755-fxfsr9bj	186	31	within	within	IN
cord-301755-fxfsr9bj	186	32	NT	NT	NNP
cord-301755-fxfsr9bj	186	33	1500-l	1500-l	CD
cord-301755-fxfsr9bj	186	34	950	950	CD
cord-301755-fxfsr9bj	186	35	and	and	CC
cord-301755-fxfsr9bj	186	36	(	(	-LRB-
cord-301755-fxfsr9bj	186	37	2	2	LS
cord-301755-fxfsr9bj	186	38	)	)	-RRB-
cord-301755-fxfsr9bj	186	39	a	a	DT
cord-301755-fxfsr9bj	186	40	second	second	JJ
cord-301755-fxfsr9bj	186	41	region	region	NN
cord-301755-fxfsr9bj	186	42	on	on	IN
cord-301755-fxfsr9bj	186	43	S2	s2	NN
cord-301755-fxfsr9bj	186	44	around	around	IN
cord-301755-fxfsr9bj	186	45	NT	NT	NNP
cord-301755-fxfsr9bj	186	46	3340	3340	CD
cord-301755-fxfsr9bj	186	47	.	.	.
cord-301755-fxfsr9bj	187	1	Preservation	preservation	NN
cord-301755-fxfsr9bj	187	2	of	of	IN
cord-301755-fxfsr9bj	187	3	the	the	DT
cord-301755-fxfsr9bj	187	4	parental	parental	JJ
cord-301755-fxfsr9bj	187	5	(	(	-LRB-
cord-301755-fxfsr9bj	187	6	wildtype	wildtype	NN
cord-301755-fxfsr9bj	187	7	)	)	-RRB-
cord-301755-fxfsr9bj	187	8	sequences	sequence	NNS
cord-301755-fxfsr9bj	187	9	at	at	IN
cord-301755-fxfsr9bj	187	10	both	both	DT
cord-301755-fxfsr9bj	187	11	of	of	IN
cord-301755-fxfsr9bj	187	12	these	these	DT
cord-301755-fxfsr9bj	187	13	regions	region	NNS
cord-301755-fxfsr9bj	187	14	appears	appear	VBZ
cord-301755-fxfsr9bj	187	15	to	to	TO
cord-301755-fxfsr9bj	187	16	be	be	VB
cord-301755-fxfsr9bj	187	17	required	require	VBN
cord-301755-fxfsr9bj	187	18	for	for	IN
cord-301755-fxfsr9bj	187	19	the	the	DT
cord-301755-fxfsr9bj	187	20	ability	ability	NN
cord-301755-fxfsr9bj	187	21	of	of	IN
cord-301755-fxfsr9bj	187	22	virus	virus	NN
cord-301755-fxfsr9bj	187	23	to	to	TO
cord-301755-fxfsr9bj	187	24	cause	cause	VB
cord-301755-fxfsr9bj	187	25	fatal	fatal	JJ
cord-301755-fxfsr9bj	187	26	encephalitis	encephalitis	RB
cord-301755-fxfsr9bj	187	27	,	,	,
cord-301755-fxfsr9bj	187	28	since	since	IN
cord-301755-fxfsr9bj	187	29	mutations	mutation	NNS
cord-301755-fxfsr9bj	187	30	at	at	IN
cord-301755-fxfsr9bj	187	31	either	either	DT
cord-301755-fxfsr9bj	187	32	site	site	NN
cord-301755-fxfsr9bj	187	33	reduced	reduce	VBN
cord-301755-fxfsr9bj	187	34	neurovirulence	neurovirulence	NN
cord-301755-fxfsr9bj	187	35	.	.	.
cord-301755-fxfsr9bj	188	1	The	the	DT
cord-301755-fxfsr9bj	188	2	mutation	mutation	NN
cord-301755-fxfsr9bj	188	3	in	in	IN
cord-301755-fxfsr9bj	188	4	S2	S2	NNP
cord-301755-fxfsr9bj	188	5	(	(	-LRB-
cord-301755-fxfsr9bj	188	6	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	188	7	-	-	HYPH
cord-301755-fxfsr9bj	188	8	l	l	NN
cord-301755-fxfsr9bj	188	9	)	)	-RRB-
cord-301755-fxfsr9bj	188	10	converted	convert	VBD
cord-301755-fxfsr9bj	188	11	the	the	DT
cord-301755-fxfsr9bj	188	12	parental	parental	JJ
cord-301755-fxfsr9bj	188	13	JHM	JHM	NNP
cord-301755-fxfsr9bj	188	14	virus	virus	NN
cord-301755-fxfsr9bj	188	15	,	,	,
cord-301755-fxfsr9bj	188	16	which	which	WDT
cord-301755-fxfsr9bj	188	17	was	be	VBD
cord-301755-fxfsr9bj	188	18	highly	highly	RB
cord-301755-fxfsr9bj	188	19	encephalitic	encephalitic	JJ
cord-301755-fxfsr9bj	188	20	,	,	,
cord-301755-fxfsr9bj	188	21	into	into	IN
cord-301755-fxfsr9bj	188	22	a	a	DT
cord-301755-fxfsr9bj	188	23	highly	highly	RB
cord-301755-fxfsr9bj	188	24	demyelinating	demyelinating	JJ
cord-301755-fxfsr9bj	188	25	virus	virus	NN
cord-301755-fxfsr9bj	188	26	,	,	,
cord-301755-fxfsr9bj	188	27	and	and	CC
cord-301755-fxfsr9bj	188	28	an	an	DT
cord-301755-fxfsr9bj	188	29	additional	additional	JJ
cord-301755-fxfsr9bj	188	30	mutation	mutation	NN
cord-301755-fxfsr9bj	188	31	(	(	-LRB-
cord-301755-fxfsr9bj	188	32	deletion	deletion	NN
cord-301755-fxfsr9bj	188	33	)	)	-RRB-
cord-301755-fxfsr9bj	188	34	in	in	IN
cord-301755-fxfsr9bj	188	35	Sl	Sl	NNP
cord-301755-fxfsr9bj	188	36	(	(	-LRB-
cord-301755-fxfsr9bj	188	37	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	188	38	)	)	-RRB-
cord-301755-fxfsr9bj	188	39	led	lead	VBD
cord-301755-fxfsr9bj	188	40	to	to	IN
cord-301755-fxfsr9bj	188	41	an	an	DT
cord-301755-fxfsr9bj	188	42	essentially	essentially	RB
cord-301755-fxfsr9bj	188	43	non	non	JJ
cord-301755-fxfsr9bj	188	44	-	-	JJ
cord-301755-fxfsr9bj	188	45	demyelinating	demyelinating	JJ
cord-301755-fxfsr9bj	188	46	virus	virus	NN
cord-301755-fxfsr9bj	188	47	(	(	-LRB-
cord-301755-fxfsr9bj	188	48	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	188	49	et	et	NNP
cord-301755-fxfsr9bj	188	50	al	al	NNP
cord-301755-fxfsr9bj	188	51	.	.	NNP
cord-301755-fxfsr9bj	188	52	,	,	,
cord-301755-fxfsr9bj	188	53	1987	1987	CD
cord-301755-fxfsr9bj	188	54	)	)	-RRB-
cord-301755-fxfsr9bj	189	1	(	(	-LRB-
cord-301755-fxfsr9bj	189	2	Table	table	NN
cord-301755-fxfsr9bj	189	3	1	1	CD
cord-301755-fxfsr9bj	189	4	)	)	-RRB-
cord-301755-fxfsr9bj	189	5	.	.	.
cord-301755-fxfsr9bj	190	1	This	this	DT
cord-301755-fxfsr9bj	190	2	result	result	NN
cord-301755-fxfsr9bj	190	3	was	be	VBD
cord-301755-fxfsr9bj	190	4	consistent	consistent	JJ
cord-301755-fxfsr9bj	190	5	with	with	IN
cord-301755-fxfsr9bj	190	6	the	the	DT
cord-301755-fxfsr9bj	190	7	interpretation	interpretation	NN
cord-301755-fxfsr9bj	190	8	that	that	IN
cord-301755-fxfsr9bj	190	9	the	the	DT
cord-301755-fxfsr9bj	190	10	site	site	NN
cord-301755-fxfsr9bj	190	11	on	on	IN
cord-301755-fxfsr9bj	190	12	Sl	Sl	NNP
cord-301755-fxfsr9bj	190	13	was	be	VBD
cord-301755-fxfsr9bj	190	14	tightly	tightly	RB
cord-301755-fxfsr9bj	190	15	associated	associate	VBN
cord-301755-fxfsr9bj	190	16	with	with	IN
cord-301755-fxfsr9bj	190	17	demyelination	demyelination	NN
cord-301755-fxfsr9bj	190	18	,	,	,
cord-301755-fxfsr9bj	190	19	while	while	IN
cord-301755-fxfsr9bj	190	20	the	the	DT
cord-301755-fxfsr9bj	190	21	site	site	NN
cord-301755-fxfsr9bj	190	22	on	on	IN
cord-301755-fxfsr9bj	190	23	S2	S2	NNP
cord-301755-fxfsr9bj	190	24	was	be	VBD
cord-301755-fxfsr9bj	190	25	responsible	responsible	JJ
cord-301755-fxfsr9bj	190	26	for	for	IN
cord-301755-fxfsr9bj	190	27	encephalitis	encephalitis	NN
cord-301755-fxfsr9bj	190	28	.	.	.
cord-301755-fxfsr9bj	191	1	However	however	RB
cord-301755-fxfsr9bj	191	2	,	,	,
cord-301755-fxfsr9bj	191	3	this	this	DT
cord-301755-fxfsr9bj	191	4	interpretation	interpretation	NN
cord-301755-fxfsr9bj	191	5	is	be	VBZ
cord-301755-fxfsr9bj	191	6	unlikely	unlikely	JJ
cord-301755-fxfsr9bj	191	7	,	,	,
cord-301755-fxfsr9bj	191	8	since	since	IN
cord-301755-fxfsr9bj	191	9	other	other	JJ
cord-301755-fxfsr9bj	191	10	neutralization	neutralization	NN
cord-301755-fxfsr9bj	191	11	-	-	HYPH
cord-301755-fxfsr9bj	191	12	resistant	resistant	JJ
cord-301755-fxfsr9bj	191	13	mutants	mutant	NNS
cord-301755-fxfsr9bj	191	14	with	with	IN
cord-301755-fxfsr9bj	191	15	deletions	deletion	NNS
cord-301755-fxfsr9bj	191	16	in	in	IN
cord-301755-fxfsr9bj	191	17	the	the	DT
cord-301755-fxfsr9bj	191	18	same	same	JJ
cord-301755-fxfsr9bj	191	19	domain	domain	NN
cord-301755-fxfsr9bj	191	20	of	of	IN
cord-301755-fxfsr9bj	191	21	Sl	sl	NN
cord-301755-fxfsr9bj	191	22	still	still	RB
cord-301755-fxfsr9bj	191	23	caused	cause	VBD
cord-301755-fxfsr9bj	191	24	demyelination	demyelination	NN
cord-301755-fxfsr9bj	191	25	(	(	-LRB-
cord-301755-fxfsr9bj	191	26	Dalziel	Dalziel	NNP
cord-301755-fxfsr9bj	191	27	et	et	NNP
cord-301755-fxfsr9bj	191	28	al	al	NNP
cord-301755-fxfsr9bj	191	29	.	.	NNP
cord-301755-fxfsr9bj	191	30	,	,	,
cord-301755-fxfsr9bj	191	31	1986	1986	CD
cord-301755-fxfsr9bj	191	32	;	;	:
cord-301755-fxfsr9bj	191	33	Gallagher	Gallagher	NNP
cord-301755-fxfsr9bj	191	34	et	et	NNP
cord-301755-fxfsr9bj	191	35	a/.	a/.	NNP
cord-301755-fxfsr9bj	191	36	,	,	,
cord-301755-fxfsr9bj	191	37	1990	1990	CD
cord-301755-fxfsr9bj	191	38	)	)	-RRB-
cord-301755-fxfsr9bj	191	39	.	.	.
cord-301755-fxfsr9bj	192	1	Thus	thus	RB
cord-301755-fxfsr9bj	192	2	,	,	,
cord-301755-fxfsr9bj	192	3	we	-PRON-	PRP
cord-301755-fxfsr9bj	192	4	hypothesize	hypothesize	VBP
cord-301755-fxfsr9bj	192	5	that	that	IN
cord-301755-fxfsr9bj	192	6	the	the	DT
cord-301755-fxfsr9bj	192	7	virtual	virtual	JJ
cord-301755-fxfsr9bj	192	8	inability	inability	NN
cord-301755-fxfsr9bj	192	9	of	of	IN
cord-301755-fxfsr9bj	192	10	2.217.2-V-2	2.217.2-v-2	CD
cord-301755-fxfsr9bj	192	11	to	to	TO
cord-301755-fxfsr9bj	192	12	cause	cause	VB
cord-301755-fxfsr9bj	192	13	demyelination	demyelination	NN
cord-301755-fxfsr9bj	192	14	or	or	CC
cord-301755-fxfsr9bj	192	15	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	193	1	(	(	-LRB-
cord-301755-fxfsr9bj	193	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	193	3	et	et	NNP
cord-301755-fxfsr9bj	193	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	193	5	,	,	,
cord-301755-fxfsr9bj	193	6	1987	1987	CD
cord-301755-fxfsr9bj	193	7	)	)	-RRB-
cord-301755-fxfsr9bj	193	8	was	be	VBD
cord-301755-fxfsr9bj	193	9	due	due	JJ
cord-301755-fxfsr9bj	193	10	to	to	IN
cord-301755-fxfsr9bj	193	11	viral	viral	JJ
cord-301755-fxfsr9bj	193	12	attenuation	attenuation	NN
cord-301755-fxfsr9bj	193	13	that	that	WDT
cord-301755-fxfsr9bj	193	14	occurred	occur	VBD
cord-301755-fxfsr9bj	193	15	when	when	WRB
cord-301755-fxfsr9bj	193	16	both	both	CC
cord-301755-fxfsr9bj	193	17	the	the	DT
cord-301755-fxfsr9bj	193	18	Sl	Sl	NNP
cord-301755-fxfsr9bj	193	19	and	and	CC
cord-301755-fxfsr9bj	193	20	S2	s2	NN
cord-301755-fxfsr9bj	193	21	determinants	determinant	NNS
cord-301755-fxfsr9bj	193	22	were	be	VBD
cord-301755-fxfsr9bj	193	23	lost	lose	VBN
cord-301755-fxfsr9bj	193	24	or	or	CC
cord-301755-fxfsr9bj	193	25	mutated	mutate	VBN
cord-301755-fxfsr9bj	193	26	.	.	.
cord-301755-fxfsr9bj	194	1	Such	such	PDT
cord-301755-fxfsr9bj	194	2	an	an	DT
cord-301755-fxfsr9bj	194	3	interpretation	interpretation	NN
cord-301755-fxfsr9bj	194	4	is	be	VBZ
cord-301755-fxfsr9bj	194	5	consistent	consistent	JJ
cord-301755-fxfsr9bj	194	6	with	with	IN
cord-301755-fxfsr9bj	194	7	the	the	DT
cord-301755-fxfsr9bj	194	8	finding	finding	NN
cord-301755-fxfsr9bj	194	9	that	that	IN
cord-301755-fxfsr9bj	194	10	the	the	DT
cord-301755-fxfsr9bj	194	11	mutation	mutation	NN
cord-301755-fxfsr9bj	194	12	in	in	IN
cord-301755-fxfsr9bj	194	13	S2	S2	NNP
cord-301755-fxfsr9bj	194	14	of	of	IN
cord-301755-fxfsr9bj	194	15	the	the	DT
cord-301755-fxfsr9bj	194	16	variant	variant	JJ
cord-301755-fxfsr9bj	194	17	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	194	18	-	-	HYPH
cord-301755-fxfsr9bj	194	19	l	l	NN
cord-301755-fxfsr9bj	194	20	and	and	CC
cord-301755-fxfsr9bj	194	21	the	the	DT
cord-301755-fxfsr9bj	194	22	mutation	mutation	NN
cord-301755-fxfsr9bj	194	23	in	in	IN
cord-301755-fxfsr9bj	194	24	Sl	Sl	NNP
cord-301755-fxfsr9bj	194	25	of	of	IN
cord-301755-fxfsr9bj	194	26	other	other	JJ
cord-301755-fxfsr9bj	194	27	mutants	mutant	NNS
cord-301755-fxfsr9bj	194	28	(	(	-LRB-
cord-301755-fxfsr9bj	194	29	Dalziel	Dalziel	NNP
cord-301755-fxfsr9bj	194	30	et	et	NNP
cord-301755-fxfsr9bj	194	31	al	al	NNP
cord-301755-fxfsr9bj	194	32	.	.	NNP
cord-301755-fxfsr9bj	194	33	,	,	,
cord-301755-fxfsr9bj	194	34	1986	1986	CD
cord-301755-fxfsr9bj	194	35	)	)	-RRB-
cord-301755-fxfsr9bj	194	36	all	all	DT
cord-301755-fxfsr9bj	194	37	led	lead	VBD
cord-301755-fxfsr9bj	194	38	to	to	IN
cord-301755-fxfsr9bj	194	39	a	a	DT
cord-301755-fxfsr9bj	194	40	similar	similar	JJ
cord-301755-fxfsr9bj	194	41	demyelinating	demyelinating	JJ
cord-301755-fxfsr9bj	194	42	phenotype	phenotype	NN
cord-301755-fxfsr9bj	194	43	.	.	.
cord-301755-fxfsr9bj	195	1	This	this	DT
cord-301755-fxfsr9bj	195	2	is	be	VBZ
cord-301755-fxfsr9bj	195	3	also	also	RB
cord-301755-fxfsr9bj	195	4	consistent	consistent	JJ
cord-301755-fxfsr9bj	195	5	with	with	IN
cord-301755-fxfsr9bj	195	6	our	-PRON-	PRP$
cord-301755-fxfsr9bj	195	7	current	current	JJ
cord-301755-fxfsr9bj	195	8	understanding	understanding	NN
cord-301755-fxfsr9bj	195	9	of	of	IN
cord-301755-fxfsr9bj	195	10	the	the	DT
cord-301755-fxfsr9bj	195	11	biological	biological	JJ
cord-301755-fxfsr9bj	195	12	activities	activity	NNS
cord-301755-fxfsr9bj	195	13	of	of	IN
cord-301755-fxfsr9bj	195	14	the	the	DT
cord-301755-fxfsr9bj	195	15	S	S	NNP
cord-301755-fxfsr9bj	195	16	protein	protein	NN
cord-301755-fxfsr9bj	195	17	.	.	.
cord-301755-fxfsr9bj	196	1	The	the	DT
cord-301755-fxfsr9bj	196	2	S	S	NNP
cord-301755-fxfsr9bj	196	3	protein	protein	NN
cord-301755-fxfsr9bj	196	4	forms	form	NNS
cord-301755-fxfsr9bj	196	5	peplomers	peplomer	NNS
cord-301755-fxfsr9bj	196	6	which	which	WDT
cord-301755-fxfsr9bj	196	7	project	project	VBP
cord-301755-fxfsr9bj	196	8	from	from	IN
cord-301755-fxfsr9bj	196	9	the	the	DT
cord-301755-fxfsr9bj	196	10	surface	surface	NN
cord-301755-fxfsr9bj	196	11	of	of	IN
cord-301755-fxfsr9bj	196	12	the	the	DT
cord-301755-fxfsr9bj	196	13	MHV	MHV	NNP
cord-301755-fxfsr9bj	196	14	virion	virion	NN
cord-301755-fxfsr9bj	196	15	,	,	,
cord-301755-fxfsr9bj	196	16	and	and	CC
cord-301755-fxfsr9bj	196	17	is	be	VBZ
cord-301755-fxfsr9bj	196	18	thus	thus	RB
cord-301755-fxfsr9bj	196	19	in	in	IN
cord-301755-fxfsr9bj	196	20	an	an	DT
cord-301755-fxfsr9bj	196	21	ideal	ideal	JJ
cord-301755-fxfsr9bj	196	22	position	position	NN
cord-301755-fxfsr9bj	196	23	to	to	TO
cord-301755-fxfsr9bj	196	24	influence	influence	VB
cord-301755-fxfsr9bj	196	25	pathogenesis	pathogenesis	NN
cord-301755-fxfsr9bj	196	26	by	by	IN
cord-301755-fxfsr9bj	196	27	altering	alter	VBG
cord-301755-fxfsr9bj	196	28	viral	viral	JJ
cord-301755-fxfsr9bj	196	29	attachment	attachment	NN
cord-301755-fxfsr9bj	196	30	to	to	IN
cord-301755-fxfsr9bj	196	31	cellular	cellular	JJ
cord-301755-fxfsr9bj	196	32	receptors	receptor	NNS
cord-301755-fxfsr9bj	196	33	,	,	,
cord-301755-fxfsr9bj	196	34	by	by	IN
cord-301755-fxfsr9bj	196	35	interaction	interaction	NN
cord-301755-fxfsr9bj	196	36	with	with	IN
cord-301755-fxfsr9bj	196	37	the	the	DT
cord-301755-fxfsr9bj	196	38	immune	immune	JJ
cord-301755-fxfsr9bj	196	39	system	system	NN
cord-301755-fxfsr9bj	196	40	,	,	,
cord-301755-fxfsr9bj	196	41	by	by	IN
cord-301755-fxfsr9bj	196	42	fusion	fusion	NN
cord-301755-fxfsr9bj	196	43	of	of	IN
cord-301755-fxfsr9bj	196	44	cellular	cellular	JJ
cord-301755-fxfsr9bj	196	45	membranes	membrane	NNS
cord-301755-fxfsr9bj	196	46	(	(	-LRB-
cord-301755-fxfsr9bj	196	47	Collins	Collins	NNP
cord-301755-fxfsr9bj	196	48	et	et	NNP
cord-301755-fxfsr9bj	196	49	a/.	a/.	NN
cord-301755-fxfsr9bj	196	50	,	,	,
cord-301755-fxfsr9bj	196	51	1982	1982	CD
cord-301755-fxfsr9bj	196	52	;	;	:
cord-301755-fxfsr9bj	196	53	Sturman	Sturman	NNP
cord-301755-fxfsr9bj	196	54	et	et	NNP
cord-301755-fxfsr9bj	196	55	a/.	a/.	NNP
cord-301755-fxfsr9bj	196	56	,	,	,
cord-301755-fxfsr9bj	196	57	1985	1985	CD
cord-301755-fxfsr9bj	196	58	)	)	-RRB-
cord-301755-fxfsr9bj	196	59	and	and	CC
cord-301755-fxfsr9bj	196	60	perhaps	perhaps	RB
cord-301755-fxfsr9bj	196	61	by	by	IN
cord-301755-fxfsr9bj	196	62	other	other	JJ
cord-301755-fxfsr9bj	196	63	mechanisms	mechanism	NNS
cord-301755-fxfsr9bj	196	64	,	,	,
cord-301755-fxfsr9bj	196	65	such	such	JJ
cord-301755-fxfsr9bj	196	66	as	as	IN
cord-301755-fxfsr9bj	196	67	influencing	influence	VBG
cord-301755-fxfsr9bj	196	68	viral	viral	JJ
cord-301755-fxfsr9bj	196	69	stability	stability	NN
cord-301755-fxfsr9bj	196	70	,	,	,
cord-301755-fxfsr9bj	196	71	uncoating	uncoating	NN
cord-301755-fxfsr9bj	196	72	,	,	,
cord-301755-fxfsr9bj	196	73	or	or	CC
cord-301755-fxfsr9bj	196	74	spread	spread	VB
cord-301755-fxfsr9bj	196	75	.	.	.
cord-301755-fxfsr9bj	197	1	After	after	IN
cord-301755-fxfsr9bj	197	2	intracerebral	intracerebral	JJ
cord-301755-fxfsr9bj	197	3	inoculation	inoculation	NN
cord-301755-fxfsr9bj	197	4	,	,	,
cord-301755-fxfsr9bj	197	5	parental	parental	JJ
cord-301755-fxfsr9bj	197	6	JHM	JHM	NNP
cord-301755-fxfsr9bj	197	7	-	-	HYPH
cord-301755-fxfsr9bj	197	8	DL	DL	NNP
cord-301755-fxfsr9bj	197	9	rapidly	rapidly	RB
cord-301755-fxfsr9bj	197	10	gains	gain	VBZ
cord-301755-fxfsr9bj	197	11	entry	entry	NN
cord-301755-fxfsr9bj	197	12	to	to	IN
cord-301755-fxfsr9bj	197	13	glia	glia	NNS
cord-301755-fxfsr9bj	197	14	and	and	CC
cord-301755-fxfsr9bj	197	15	neurons	neuron	NNS
cord-301755-fxfsr9bj	197	16	throughout	throughout	IN
cord-301755-fxfsr9bj	197	17	the	the	DT
cord-301755-fxfsr9bj	197	18	CNS	CNS	NNP
cord-301755-fxfsr9bj	197	19	and	and	CC
cord-301755-fxfsr9bj	197	20	thus	thus	RB
cord-301755-fxfsr9bj	197	21	is	be	VBZ
cord-301755-fxfsr9bj	197	22	able	able	JJ
cord-301755-fxfsr9bj	197	23	to	to	TO
cord-301755-fxfsr9bj	197	24	cause	cause	VB
cord-301755-fxfsr9bj	197	25	fatal	fatal	JJ
cord-301755-fxfsr9bj	197	26	panencephalitis	panencephalitis	NN
cord-301755-fxfsr9bj	197	27	(	(	-LRB-
cord-301755-fxfsr9bj	197	28	Weiner	Weiner	NNP
cord-301755-fxfsr9bj	197	29	,	,	,
cord-301755-fxfsr9bj	197	30	1973	1973	CD
cord-301755-fxfsr9bj	197	31	;	;	:
cord-301755-fxfsr9bj	197	32	Knobler	Knobler	NNP
cord-301755-fxfsr9bj	197	33	et	et	NNP
cord-301755-fxfsr9bj	197	34	a/.	a/.	NNP
cord-301755-fxfsr9bj	197	35	,	,	,
cord-301755-fxfsr9bj	197	36	1981	1981	CD
cord-301755-fxfsr9bj	197	37	)	)	-RRB-
cord-301755-fxfsr9bj	197	38	.	.	.
cord-301755-fxfsr9bj	198	1	By	by	IN
cord-301755-fxfsr9bj	198	2	contrast	contrast	NN
cord-301755-fxfsr9bj	198	3	,	,	,
cord-301755-fxfsr9bj	198	4	MAb	MAb	NNS
cord-301755-fxfsr9bj	198	5	-	-	HYPH
cord-301755-fxfsr9bj	198	6	selected	select	VBN
cord-301755-fxfsr9bj	198	7	JHM	JHM	NNP
cord-301755-fxfsr9bj	198	8	mutants	mutant	NNS
cord-301755-fxfsr9bj	198	9	(	(	-LRB-
cord-301755-fxfsr9bj	198	10	2.2-V-1	2.2-v-1	CD
cord-301755-fxfsr9bj	198	11	and	and	CC
cord-301755-fxfsr9bj	198	12	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	198	13	)	)	-RRB-
cord-301755-fxfsr9bj	198	14	are	be	VBP
cord-301755-fxfsr9bj	198	15	less	less	RBR
cord-301755-fxfsr9bj	198	16	able	able	JJ
cord-301755-fxfsr9bj	198	17	to	to	TO
cord-301755-fxfsr9bj	198	18	spread	spread	VB
cord-301755-fxfsr9bj	198	19	to	to	IN
cord-301755-fxfsr9bj	198	20	neurons	neuron	NNS
cord-301755-fxfsr9bj	198	21	,	,	,
cord-301755-fxfsr9bj	198	22	and	and	CC
cord-301755-fxfsr9bj	198	23	virulence	virulence	NN
cord-301755-fxfsr9bj	198	24	is	be	VBZ
cord-301755-fxfsr9bj	198	25	thus	thus	RB
cord-301755-fxfsr9bj	198	26	drastically	drastically	RB
cord-301755-fxfsr9bj	198	27	reduced	reduce	VBN
cord-301755-fxfsr9bj	198	28	(	(	-LRB-
cord-301755-fxfsr9bj	198	29	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	198	30	et	et	NNP
cord-301755-fxfsr9bj	198	31	a/	a/	NNP
cord-301755-fxfsr9bj	198	32	,	,	,
cord-301755-fxfsr9bj	198	33	,	,	,
cord-301755-fxfsr9bj	198	34	1986	1986	CD
cord-301755-fxfsr9bj	198	35	)	)	-RRB-
cord-301755-fxfsr9bj	198	36	.	.	.
cord-301755-fxfsr9bj	199	1	However	however	RB
cord-301755-fxfsr9bj	199	2	,	,	,
cord-301755-fxfsr9bj	199	3	these	these	DT
cord-301755-fxfsr9bj	199	4	viruses	virus	NNS
cord-301755-fxfsr9bj	199	5	are	be	VBP
cord-301755-fxfsr9bj	199	6	able	able	JJ
cord-301755-fxfsr9bj	199	7	to	to	TO
cord-301755-fxfsr9bj	199	8	infect	infect	VB
cord-301755-fxfsr9bj	199	9	glial	glial	JJ
cord-301755-fxfsr9bj	199	10	cells	cell	NNS
cord-301755-fxfsr9bj	199	11	of	of	IN
cord-301755-fxfsr9bj	199	12	the	the	DT
cord-301755-fxfsr9bj	199	13	white	white	JJ
cord-301755-fxfsr9bj	199	14	matter	matter	NN
cord-301755-fxfsr9bj	199	15	of	of	IN
cord-301755-fxfsr9bj	199	16	the	the	DT
cord-301755-fxfsr9bj	199	17	brain	brain	NN
cord-301755-fxfsr9bj	199	18	and	and	CC
cord-301755-fxfsr9bj	199	19	spinal	spinal	JJ
cord-301755-fxfsr9bj	199	20	cord	cord	NN
cord-301755-fxfsr9bj	199	21	.	.	.
cord-301755-fxfsr9bj	200	1	Presumably	presumably	RB
cord-301755-fxfsr9bj	200	2	the	the	DT
cord-301755-fxfsr9bj	200	3	requirements	requirement	NNS
cord-301755-fxfsr9bj	200	4	of	of	IN
cord-301755-fxfsr9bj	200	5	viral	viral	JJ
cord-301755-fxfsr9bj	200	6	entry	entry	NN
cord-301755-fxfsr9bj	200	7	or	or	CC
cord-301755-fxfsr9bj	200	8	replication	replication	NN
cord-301755-fxfsr9bj	200	9	in	in	IN
cord-301755-fxfsr9bj	200	10	glial	glial	JJ
cord-301755-fxfsr9bj	200	11	cells	cell	NNS
cord-301755-fxfsr9bj	200	12	are	be	VBP
cord-301755-fxfsr9bj	200	13	less	less	RBR
cord-301755-fxfsr9bj	200	14	stringent	stringent	JJ
cord-301755-fxfsr9bj	200	15	than	than	IN
cord-301755-fxfsr9bj	200	16	those	those	DT
cord-301755-fxfsr9bj	200	17	for	for	IN
cord-301755-fxfsr9bj	200	18	neuronal	neuronal	JJ
cord-301755-fxfsr9bj	200	19	infection	infection	NN
cord-301755-fxfsr9bj	200	20	.	.	.
cord-301755-fxfsr9bj	201	1	This	this	DT
cord-301755-fxfsr9bj	201	2	differential	differential	JJ
cord-301755-fxfsr9bj	201	3	entry	entry	NN
cord-301755-fxfsr9bj	201	4	may	may	MD
cord-301755-fxfsr9bj	201	5	reflect	reflect	VB
cord-301755-fxfsr9bj	201	6	the	the	DT
cord-301755-fxfsr9bj	201	7	presence	presence	NN
cord-301755-fxfsr9bj	201	8	of	of	IN
cord-301755-fxfsr9bj	201	9	different	different	JJ
cord-301755-fxfsr9bj	201	10	receptors	receptor	NNS
cord-301755-fxfsr9bj	201	11	utilized	utilize	VBN
cord-301755-fxfsr9bj	201	12	by	by	IN
cord-301755-fxfsr9bj	201	13	wild	wild	JJ
cord-301755-fxfsr9bj	201	14	-	-	HYPH
cord-301755-fxfsr9bj	201	15	type	type	NN
cord-301755-fxfsr9bj	201	16	virus	virus	NN
cord-301755-fxfsr9bj	201	17	versus	versus	IN
cord-301755-fxfsr9bj	201	18	selected	select	VBN
cord-301755-fxfsr9bj	201	19	variants	variant	NNS
cord-301755-fxfsr9bj	201	20	.	.	.
cord-301755-fxfsr9bj	202	1	In	in	IN
cord-301755-fxfsr9bj	202	2	addition	addition	NN
cord-301755-fxfsr9bj	202	3	,	,	,
cord-301755-fxfsr9bj	202	4	the	the	DT
cord-301755-fxfsr9bj	202	5	susceptibility	susceptibility	NN
cord-301755-fxfsr9bj	202	6	of	of	IN
cord-301755-fxfsr9bj	202	7	different	different	JJ
cord-301755-fxfsr9bj	202	8	neural	neural	JJ
cord-301755-fxfsr9bj	202	9	cells	cell	NNS
cord-301755-fxfsr9bj	202	10	to	to	IN
cord-301755-fxfsr9bj	202	11	JHM	JHM	NNP
cord-301755-fxfsr9bj	202	12	is	be	VBZ
cord-301755-fxfsr9bj	202	13	known	know	VBN
cord-301755-fxfsr9bj	202	14	to	to	TO
cord-301755-fxfsr9bj	202	15	be	be	VB
cord-301755-fxfsr9bj	202	16	affected	affect	VBN
cord-301755-fxfsr9bj	202	17	by	by	IN
cord-301755-fxfsr9bj	202	18	the	the	DT
cord-301755-fxfsr9bj	202	19	developmental	developmental	JJ
cord-301755-fxfsr9bj	202	20	stages	stage	NNS
cord-301755-fxfsr9bj	202	21	of	of	IN
cord-301755-fxfsr9bj	202	22	different	different	JJ
cord-301755-fxfsr9bj	202	23	cell	cell	NN
cord-301755-fxfsr9bj	202	24	species	specie	NNS
cord-301755-fxfsr9bj	202	25	and	and	CC
cord-301755-fxfsr9bj	202	26	host	host	NN
cord-301755-fxfsr9bj	202	27	factors	factor	NNS
cord-301755-fxfsr9bj	202	28	(	(	-LRB-
cord-301755-fxfsr9bj	202	29	Pasick	Pasick	NNP
cord-301755-fxfsr9bj	202	30	and	and	CC
cord-301755-fxfsr9bj	202	31	Dales	Dales	NNP
cord-301755-fxfsr9bj	202	32	,	,	,
cord-301755-fxfsr9bj	202	33	1991	1991	CD
cord-301755-fxfsr9bj	202	34	)	)	-RRB-
cord-301755-fxfsr9bj	202	35	.	.	.
cord-301755-fxfsr9bj	203	1	In	in	IN
cord-301755-fxfsr9bj	203	2	the	the	DT
cord-301755-fxfsr9bj	203	3	case	case	NN
cord-301755-fxfsr9bj	203	4	of	of	IN
cord-301755-fxfsr9bj	203	5	infection	infection	NN
cord-301755-fxfsr9bj	203	6	by	by	IN
cord-301755-fxfsr9bj	203	7	JHM	JHM	NNP
cord-301755-fxfsr9bj	203	8	mutants	mutant	NNS
cord-301755-fxfsr9bj	203	9	,	,	,
cord-301755-fxfsr9bj	203	10	the	the	DT
cord-301755-fxfsr9bj	203	11	immune	immune	JJ
cord-301755-fxfsr9bj	203	12	response	response	NN
cord-301755-fxfsr9bj	203	13	clears	clear	VBZ
cord-301755-fxfsr9bj	203	14	virus	virus	NN
cord-301755-fxfsr9bj	203	15	from	from	IN
cord-301755-fxfsr9bj	203	16	the	the	DT
cord-301755-fxfsr9bj	203	17	white	white	JJ
cord-301755-fxfsr9bj	203	18	matter	matter	NN
cord-301755-fxfsr9bj	203	19	by	by	IN
cord-301755-fxfsr9bj	203	20	12	12	CD
cord-301755-fxfsr9bj	203	21	days	day	NNS
cord-301755-fxfsr9bj	203	22	postinoculation	postinoculation	NN
cord-301755-fxfsr9bj	203	23	but	but	CC
cord-301755-fxfsr9bj	203	24	has	have	VBZ
cord-301755-fxfsr9bj	203	25	the	the	DT
cord-301755-fxfsr9bj	203	26	deleterious	deleterious	JJ
cord-301755-fxfsr9bj	203	27	consequence	consequence	NN
cord-301755-fxfsr9bj	203	28	of	of	IN
cord-301755-fxfsr9bj	203	29	inducing	induce	VBG
cord-301755-fxfsr9bj	203	30	myelin	myelin	JJ
cord-301755-fxfsr9bj	203	31	loss	loss	NN
cord-301755-fxfsr9bj	203	32	(	(	-LRB-
cord-301755-fxfsr9bj	203	33	Wang	Wang	NNP
cord-301755-fxfsr9bj	203	34	eT	eT	NNP
cord-301755-fxfsr9bj	203	35	al	al	NNP
cord-301755-fxfsr9bj	203	36	.	.	NNP
cord-301755-fxfsr9bj	203	37	,	,	,
cord-301755-fxfsr9bj	203	38	1990	1990	CD
cord-301755-fxfsr9bj	203	39	)	)	-RRB-
cord-301755-fxfsr9bj	203	40	.	.	.
cord-301755-fxfsr9bj	204	1	Thus	thus	RB
cord-301755-fxfsr9bj	204	2	,	,	,
cord-301755-fxfsr9bj	204	3	the	the	DT
cord-301755-fxfsr9bj	204	4	apparent	apparent	JJ
cord-301755-fxfsr9bj	204	5	increase	increase	NN
cord-301755-fxfsr9bj	204	6	in	in	IN
cord-301755-fxfsr9bj	204	7	ability	ability	NN
cord-301755-fxfsr9bj	204	8	to	to	TO
cord-301755-fxfsr9bj	204	9	cause	cause	VB
cord-301755-fxfsr9bj	204	10	demyelination	demyelination	NN
cord-301755-fxfsr9bj	204	11	shown	show	VBN
cord-301755-fxfsr9bj	204	12	by	by	IN
cord-301755-fxfsr9bj	204	13	these	these	DT
cord-301755-fxfsr9bj	204	14	and	and	CC
cord-301755-fxfsr9bj	204	15	similar	similar	JJ
cord-301755-fxfsr9bj	204	16	variants	variant	NNS
cord-301755-fxfsr9bj	205	1	(	(	-LRB-
cord-301755-fxfsr9bj	205	2	Dalziel	Dalziel	NNP
cord-301755-fxfsr9bj	205	3	et	et	NNP
cord-301755-fxfsr9bj	205	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	205	5	,	,	,
cord-301755-fxfsr9bj	205	6	1986	1986	CD
cord-301755-fxfsr9bj	205	7	;	;	:
cord-301755-fxfsr9bj	205	8	Wege	Wege	NNP
cord-301755-fxfsr9bj	205	9	et	et	NNP
cord-301755-fxfsr9bj	205	10	a/.	a/.	NNP
cord-301755-fxfsr9bj	205	11	,	,	,
cord-301755-fxfsr9bj	205	12	1988	1988	CD
cord-301755-fxfsr9bj	205	13	)	)	-RRB-
cord-301755-fxfsr9bj	205	14	is	be	VBZ
cord-301755-fxfsr9bj	205	15	probably	probably	RB
cord-301755-fxfsr9bj	205	16	due	due	JJ
cord-301755-fxfsr9bj	205	17	to	to	IN
cord-301755-fxfsr9bj	205	18	the	the	DT
cord-301755-fxfsr9bj	205	19	unmasking	unmasking	NN
cord-301755-fxfsr9bj	205	20	of	of	IN
cord-301755-fxfsr9bj	205	21	potentialities	potentiality	NNS
cord-301755-fxfsr9bj	205	22	of	of	IN
cord-301755-fxfsr9bj	205	23	the	the	DT
cord-301755-fxfsr9bj	205	24	parental	parental	JJ
cord-301755-fxfsr9bj	205	25	virus	virus	NN
cord-301755-fxfsr9bj	205	26	which	which	WDT
cord-301755-fxfsr9bj	205	27	are	be	VBP
cord-301755-fxfsr9bj	205	28	usually	usually	RB
cord-301755-fxfsr9bj	205	29	hidden	hide	VBN
cord-301755-fxfsr9bj	205	30	by	by	IN
cord-301755-fxfsr9bj	205	31	its	-PRON-	PRP$
cord-301755-fxfsr9bj	205	32	virulence	virulence	NN
cord-301755-fxfsr9bj	205	33	.	.	.
cord-301755-fxfsr9bj	206	1	The	the	DT
cord-301755-fxfsr9bj	206	2	ability	ability	NN
cord-301755-fxfsr9bj	206	3	of	of	IN
cord-301755-fxfsr9bj	206	4	mutations	mutation	NNS
cord-301755-fxfsr9bj	206	5	at	at	IN
cord-301755-fxfsr9bj	206	6	different	different	JJ
cord-301755-fxfsr9bj	206	7	sites	site	NNS
cord-301755-fxfsr9bj	206	8	to	to	TO
cord-301755-fxfsr9bj	206	9	affect	affect	VB
cord-301755-fxfsr9bj	206	10	the	the	DT
cord-301755-fxfsr9bj	206	11	same	same	JJ
cord-301755-fxfsr9bj	206	12	biological	biological	JJ
cord-301755-fxfsr9bj	206	13	properties	property	NNS
cord-301755-fxfsr9bj	206	14	of	of	IN
cord-301755-fxfsr9bj	206	15	the	the	DT
cord-301755-fxfsr9bj	206	16	S	S	NNP
cord-301755-fxfsr9bj	206	17	protein	protein	NN
cord-301755-fxfsr9bj	206	18	was	be	VBD
cord-301755-fxfsr9bj	206	19	further	further	RB
cord-301755-fxfsr9bj	206	20	demonstrated	demonstrate	VBN
cord-301755-fxfsr9bj	206	21	by	by	IN
cord-301755-fxfsr9bj	206	22	the	the	DT
cord-301755-fxfsr9bj	206	23	sequence	sequence	NN
cord-301755-fxfsr9bj	206	24	analysis	analysis	NN
cord-301755-fxfsr9bj	206	25	of	of	IN
cord-301755-fxfsr9bj	206	26	a	a	DT
cord-301755-fxfsr9bj	206	27	partial	partial	JJ
cord-301755-fxfsr9bj	206	28	revertant	revertant	NN
cord-301755-fxfsr9bj	206	29	of	of	IN
cord-301755-fxfsr9bj	206	30	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	206	31	-	-	HYPH
cord-301755-fxfsr9bj	206	32	l	l	NN
cord-301755-fxfsr9bj	206	33	.	.	.
cord-301755-fxfsr9bj	207	1	The	the	DT
cord-301755-fxfsr9bj	207	2	second	second	JJ
cord-301755-fxfsr9bj	207	3	site	site	NN
cord-301755-fxfsr9bj	207	4	mutation	mutation	NN
cord-301755-fxfsr9bj	207	5	which	which	WDT
cord-301755-fxfsr9bj	207	6	partially	partially	RB
cord-301755-fxfsr9bj	207	7	restored	restore	VBD
cord-301755-fxfsr9bj	207	8	the	the	DT
cord-301755-fxfsr9bj	207	9	MAb	MAb	NNS
cord-301755-fxfsr9bj	207	10	sensitivity	sensitivity	NN
cord-301755-fxfsr9bj	207	11	of	of	IN
cord-301755-fxfsr9bj	207	12	this	this	DT
cord-301755-fxfsr9bj	207	13	virus	virus	NN
cord-301755-fxfsr9bj	207	14	was	be	VBD
cord-301755-fxfsr9bj	207	15	localized	localize	VBN
cord-301755-fxfsr9bj	207	16	on	on	IN
cord-301755-fxfsr9bj	207	17	Sl	Sl	NNP
cord-301755-fxfsr9bj	207	18	,	,	,
cord-301755-fxfsr9bj	207	19	in	in	IN
cord-301755-fxfsr9bj	207	20	contrast	contrast	NN
cord-301755-fxfsr9bj	207	21	to	to	IN
cord-301755-fxfsr9bj	207	22	the	the	DT
cord-301755-fxfsr9bj	207	23	original	original	JJ
cord-301755-fxfsr9bj	207	24	mutation	mutation	NN
cord-301755-fxfsr9bj	207	25	on	on	IN
cord-301755-fxfsr9bj	207	26	S2	S2	NNP
cord-301755-fxfsr9bj	207	27	.	.	.
cord-301755-fxfsr9bj	208	1	This	this	DT
cord-301755-fxfsr9bj	208	2	study	study	NN
cord-301755-fxfsr9bj	208	3	suggested	suggest	VBD
cord-301755-fxfsr9bj	208	4	that	that	IN
cord-301755-fxfsr9bj	208	5	two	two	CD
cord-301755-fxfsr9bj	208	6	sterically	sterically	RB
cord-301755-fxfsr9bj	208	7	separated	separate	VBN
cord-301755-fxfsr9bj	208	8	sites	site	NNS
cord-301755-fxfsr9bj	208	9	(	(	-LRB-
cord-301755-fxfsr9bj	208	10	one	one	CD
cord-301755-fxfsr9bj	208	11	in	in	IN
cord-301755-fxfsr9bj	208	12	the	the	DT
cord-301755-fxfsr9bj	208	13	globular	globular	JJ
cord-301755-fxfsr9bj	208	14	portion	portion	NN
cord-301755-fxfsr9bj	208	15	,	,	,
cord-301755-fxfsr9bj	208	16	and	and	CC
cord-301755-fxfsr9bj	208	17	the	the	DT
cord-301755-fxfsr9bj	208	18	other	other	JJ
cord-301755-fxfsr9bj	208	19	in	in	IN
cord-301755-fxfsr9bj	208	20	the	the	DT
cord-301755-fxfsr9bj	208	21	heptad	heptad	NN
cord-301755-fxfsr9bj	208	22	repeat	repeat	NN
cord-301755-fxfsr9bj	208	23	region	region	NN
cord-301755-fxfsr9bj	208	24	of	of	IN
cord-301755-fxfsr9bj	208	25	the	the	DT
cord-301755-fxfsr9bj	208	26	stalk	stalk	NN
cord-301755-fxfsr9bj	208	27	portion	portion	NN
cord-301755-fxfsr9bj	208	28	according	accord	VBG
cord-301755-fxfsr9bj	208	29	to	to	IN
cord-301755-fxfsr9bj	208	30	the	the	DT
cord-301755-fxfsr9bj	208	31	computer	computer	NN
cord-301755-fxfsr9bj	208	32	modeling	modeling	NN
cord-301755-fxfsr9bj	208	33	[	[	-LRB-
cord-301755-fxfsr9bj	208	34	de	de	FW
cord-301755-fxfsr9bj	208	35	Groot	Groot	NNP
cord-301755-fxfsr9bj	208	36	et	et	FW
cord-301755-fxfsr9bj	208	37	al	al	NNP
cord-301755-fxfsr9bj	208	38	.	.	NNP
cord-301755-fxfsr9bj	208	39	,	,	,
cord-301755-fxfsr9bj	208	40	19871	19871	CD
cord-301755-fxfsr9bj	208	41	)	)	-RRB-
cord-301755-fxfsr9bj	208	42	on	on	IN
cord-301755-fxfsr9bj	208	43	the	the	DT
cord-301755-fxfsr9bj	208	44	two	two	CD
cord-301755-fxfsr9bj	208	45	different	different	JJ
cord-301755-fxfsr9bj	208	46	S	s	NN
cord-301755-fxfsr9bj	208	47	subunits	subunit	NNS
cord-301755-fxfsr9bj	208	48	could	could	MD
cord-301755-fxfsr9bj	208	49	interact	interact	VB
cord-301755-fxfsr9bj	208	50	with	with	IN
cord-301755-fxfsr9bj	208	51	each	each	DT
cord-301755-fxfsr9bj	208	52	other	other	JJ
cord-301755-fxfsr9bj	208	53	.	.	.
cord-301755-fxfsr9bj	209	1	This	this	DT
cord-301755-fxfsr9bj	209	2	effect	effect	NN
cord-301755-fxfsr9bj	209	3	has	have	VBZ
cord-301755-fxfsr9bj	209	4	also	also	RB
cord-301755-fxfsr9bj	209	5	been	be	VBN
cord-301755-fxfsr9bj	209	6	illustrated	illustrate	VBN
cord-301755-fxfsr9bj	209	7	by	by	IN
cord-301755-fxfsr9bj	209	8	the	the	DT
cord-301755-fxfsr9bj	209	9	antibody	antibody	NN
cord-301755-fxfsr9bj	209	10	sensitivity	sensitivity	NN
cord-301755-fxfsr9bj	209	11	of	of	IN
cord-301755-fxfsr9bj	209	12	2.2/7.2-V-2	2.2/7.2-v-2	CD
cord-301755-fxfsr9bj	209	13	and	and	CC
cord-301755-fxfsr9bj	209	14	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	209	15	-	-	HYPH
cord-301755-fxfsr9bj	209	16	l	l	NN
cord-301755-fxfsr9bj	209	17	.	.	.
cord-301755-fxfsr9bj	210	1	The	the	DT
cord-301755-fxfsr9bj	210	2	former	former	JJ
cord-301755-fxfsr9bj	210	3	was	be	VBD
cord-301755-fxfsr9bj	210	4	roughly	roughly	RB
cord-301755-fxfsr9bj	210	5	one	one	CD
cord-301755-fxfsr9bj	210	6	loglo	loglo	NNP
cord-301755-fxfsr9bj	210	7	more	more	RBR
cord-301755-fxfsr9bj	210	8	resistant	resistant	JJ
cord-301755-fxfsr9bj	210	9	than	than	IN
cord-301755-fxfsr9bj	210	10	the	the	DT
cord-301755-fxfsr9bj	210	11	latter	latter	JJ
cord-301755-fxfsr9bj	210	12	to	to	IN
cord-301755-fxfsr9bj	210	13	MAb	MAb	NNS
cord-301755-fxfsr9bj	210	14	J.2.2	J.2.2	NNP
cord-301755-fxfsr9bj	211	1	(	(	-LRB-
cord-301755-fxfsr9bj	211	2	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	211	3	eta/.	eta/.	CD
cord-301755-fxfsr9bj	211	4	,	,	,
cord-301755-fxfsr9bj	211	5	1987	1987	CD
cord-301755-fxfsr9bj	211	6	)	)	-RRB-
cord-301755-fxfsr9bj	211	7	,	,	,
cord-301755-fxfsr9bj	211	8	suggesting	suggest	VBG
cord-301755-fxfsr9bj	211	9	that	that	IN
cord-301755-fxfsr9bj	211	10	the	the	DT
cord-301755-fxfsr9bj	211	11	second	second	JJ
cord-301755-fxfsr9bj	211	12	mutation	mutation	NN
cord-301755-fxfsr9bj	211	13	further	further	RB
cord-301755-fxfsr9bj	211	14	altered	alter	VBD
cord-301755-fxfsr9bj	211	15	the	the	DT
cord-301755-fxfsr9bj	211	16	conformation	conformation	NN
cord-301755-fxfsr9bj	211	17	at	at	IN
cord-301755-fxfsr9bj	211	18	the	the	DT
cord-301755-fxfsr9bj	211	19	first	first	JJ
cord-301755-fxfsr9bj	211	20	site	site	NN
cord-301755-fxfsr9bj	211	21	(	(	-LRB-
cord-301755-fxfsr9bj	211	22	in	in	IN
cord-301755-fxfsr9bj	211	23	S2	S2	NNP
cord-301755-fxfsr9bj	211	24	)	)	-RRB-
cord-301755-fxfsr9bj	211	25	.	.	.
cord-301755-fxfsr9bj	212	1	Interestingly	interestingly	RB
cord-301755-fxfsr9bj	212	2	,	,	,
cord-301755-fxfsr9bj	212	3	the	the	DT
cord-301755-fxfsr9bj	212	4	partial	partial	JJ
cord-301755-fxfsr9bj	212	5	revertant	revertant	NN
cord-301755-fxfsr9bj	212	6	of	of	IN
cord-301755-fxfsr9bj	212	7	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	212	8	-	-	HYPH
cord-301755-fxfsr9bj	212	9	l	l	NN
cord-301755-fxfsr9bj	212	10	retained	retain	VBD
cord-301755-fxfsr9bj	212	11	the	the	DT
cord-301755-fxfsr9bj	212	12	same	same	JJ
cord-301755-fxfsr9bj	212	13	pathogenic	pathogenic	JJ
cord-301755-fxfsr9bj	212	14	properties	property	NNS
cord-301755-fxfsr9bj	212	15	of	of	IN
cord-301755-fxfsr9bj	212	16	the	the	DT
cord-301755-fxfsr9bj	212	17	parent	parent	NN
cord-301755-fxfsr9bj	212	18	variant	variant	NN
cord-301755-fxfsr9bj	212	19	2.2-V	2.2-v	CD
cord-301755-fxfsr9bj	212	20	-	-	HYPH
cord-301755-fxfsr9bj	212	21	l	l	NN
cord-301755-fxfsr9bj	212	22	.	.	.
cord-301755-fxfsr9bj	213	1	Furthermore	furthermore	RB
cord-301755-fxfsr9bj	213	2	,	,	,
cord-301755-fxfsr9bj	213	3	7.2-V	7.2-v	CD
cord-301755-fxfsr9bj	213	4	-	-	HYPH
cord-301755-fxfsr9bj	213	5	l	l	NN
cord-301755-fxfsr9bj	213	6	variant	variant	NN
cord-301755-fxfsr9bj	213	7	retained	retain	VBD
cord-301755-fxfsr9bj	213	8	the	the	DT
cord-301755-fxfsr9bj	213	9	ability	ability	NN
cord-301755-fxfsr9bj	213	10	to	to	TO
cord-301755-fxfsr9bj	213	11	cause	cause	VB
cord-301755-fxfsr9bj	213	12	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	213	13	(	(	-LRB-
cord-301755-fxfsr9bj	213	14	Table	table	NN
cord-301755-fxfsr9bj	213	15	1	1	CD
cord-301755-fxfsr9bj	213	16	)	)	-RRB-
cord-301755-fxfsr9bj	213	17	.	.	.
cord-301755-fxfsr9bj	214	1	These	these	DT
cord-301755-fxfsr9bj	214	2	results	result	NNS
cord-301755-fxfsr9bj	214	3	suggest	suggest	VBP
cord-301755-fxfsr9bj	214	4	that	that	IN
cord-301755-fxfsr9bj	214	5	the	the	DT
cord-301755-fxfsr9bj	214	6	antibody	antibody	NN
cord-301755-fxfsr9bj	214	7	binding	bind	VBG
cord-301755-fxfsr9bj	214	8	and	and	CC
cord-301755-fxfsr9bj	214	9	pathogenic	pathogenic	JJ
cord-301755-fxfsr9bj	214	10	properties	property	NNS
cord-301755-fxfsr9bj	214	11	of	of	IN
cord-301755-fxfsr9bj	214	12	the	the	DT
cord-301755-fxfsr9bj	214	13	S	S	NNP
cord-301755-fxfsr9bj	214	14	protein	protein	NN
cord-301755-fxfsr9bj	214	15	can	can	MD
cord-301755-fxfsr9bj	214	16	be	be	VB
cord-301755-fxfsr9bj	214	17	dissociated	dissociate	VBN
cord-301755-fxfsr9bj	214	18	.	.	.
cord-301755-fxfsr9bj	215	1	Our	-PRON-	PRP$
cord-301755-fxfsr9bj	215	2	study	study	NN
cord-301755-fxfsr9bj	215	3	also	also	RB
cord-301755-fxfsr9bj	215	4	suggested	suggest	VBD
cord-301755-fxfsr9bj	215	5	the	the	DT
cord-301755-fxfsr9bj	215	6	possible	possible	JJ
cord-301755-fxfsr9bj	215	7	presence	presence	NN
cord-301755-fxfsr9bj	215	8	of	of	IN
cord-301755-fxfsr9bj	215	9	sequence	sequence	NN
cord-301755-fxfsr9bj	215	10	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	215	11	in	in	IN
cord-301755-fxfsr9bj	215	12	the	the	DT
cord-301755-fxfsr9bj	215	13	MHVs	MHVs	NNP
cord-301755-fxfsr9bj	215	14	(	(	-LRB-
cord-301755-fxfsr9bj	215	15	Table	Table	NNP
cord-301755-fxfsr9bj	215	16	3	3	CD
cord-301755-fxfsr9bj	215	17	and	and	CC
cord-301755-fxfsr9bj	215	18	data	datum	NNS
cord-301755-fxfsr9bj	215	19	not	not	RB
cord-301755-fxfsr9bj	215	20	shown	show	VBN
cord-301755-fxfsr9bj	215	21	)	)	-RRB-
cord-301755-fxfsr9bj	215	22	.	.	.
cord-301755-fxfsr9bj	216	1	All	all	DT
cord-301755-fxfsr9bj	216	2	of	of	IN
cord-301755-fxfsr9bj	216	3	these	these	DT
cord-301755-fxfsr9bj	216	4	viruses	virus	NNS
cord-301755-fxfsr9bj	216	5	were	be	VBD
cord-301755-fxfsr9bj	216	6	initially	initially	RB
cord-301755-fxfsr9bj	216	7	plaque	plaque	NN
cord-301755-fxfsr9bj	216	8	-	-	HYPH
cord-301755-fxfsr9bj	216	9	purified	purify	VBN
cord-301755-fxfsr9bj	216	10	but	but	CC
cord-301755-fxfsr9bj	216	11	had	have	VBD
cord-301755-fxfsr9bj	216	12	been	be	VBN
cord-301755-fxfsr9bj	216	13	amplified	amplify	VBN
cord-301755-fxfsr9bj	216	14	by	by	IN
cord-301755-fxfsr9bj	216	15	limited	limited	JJ
cord-301755-fxfsr9bj	216	16	passages	passage	NNS
cord-301755-fxfsr9bj	216	17	to	to	TO
cord-301755-fxfsr9bj	216	18	obtain	obtain	VB
cord-301755-fxfsr9bj	216	19	sufficient	sufficient	JJ
cord-301755-fxfsr9bj	216	20	virus	virus	NN
cord-301755-fxfsr9bj	216	21	titer	titer	NN
cord-301755-fxfsr9bj	216	22	before	before	IN
cord-301755-fxfsr9bj	216	23	molecular	molecular	JJ
cord-301755-fxfsr9bj	216	24	cloning	cloning	NN
cord-301755-fxfsr9bj	216	25	and	and	CC
cord-301755-fxfsr9bj	216	26	sequencing	sequencing	NN
cord-301755-fxfsr9bj	216	27	.	.	.
cord-301755-fxfsr9bj	217	1	Some	some	DT
cord-301755-fxfsr9bj	217	2	of	of	IN
cord-301755-fxfsr9bj	217	3	these	these	DT
cord-301755-fxfsr9bj	217	4	sequence	sequence	NN
cord-301755-fxfsr9bj	217	5	variations	variation	NNS
cord-301755-fxfsr9bj	217	6	were	be	VBD
cord-301755-fxfsr9bj	217	7	likely	likely	RB
cord-301755-fxfsr9bj	217	8	the	the	DT
cord-301755-fxfsr9bj	217	9	results	result	NNS
cord-301755-fxfsr9bj	217	10	of	of	IN
cord-301755-fxfsr9bj	217	11	PCR	PCR	NNP
cord-301755-fxfsr9bj	217	12	and	and	CC
cord-301755-fxfsr9bj	217	13	cloning	cloning	NN
cord-301755-fxfsr9bj	217	14	errors	error	NNS
cord-301755-fxfsr9bj	217	15	.	.	.
cord-301755-fxfsr9bj	218	1	However	however	RB
cord-301755-fxfsr9bj	218	2	,	,	,
cord-301755-fxfsr9bj	218	3	several	several	JJ
cord-301755-fxfsr9bj	218	4	nucleotide	nucleotide	JJ
cord-301755-fxfsr9bj	218	5	variations	variation	NNS
cord-301755-fxfsr9bj	218	6	were	be	VBD
cord-301755-fxfsr9bj	218	7	consis	consis	NN
cord-301755-fxfsr9bj	218	8	-	-	HYPH
cord-301755-fxfsr9bj	218	9	tently	tently	RB
cord-301755-fxfsr9bj	218	10	noted	note	VBN
cord-301755-fxfsr9bj	218	11	in	in	IN
cord-301755-fxfsr9bj	218	12	repeated	repeat	VBN
cord-301755-fxfsr9bj	218	13	PCR	PCR	NNP
cord-301755-fxfsr9bj	218	14	products	product	NNS
cord-301755-fxfsr9bj	218	15	.	.	.
cord-301755-fxfsr9bj	219	1	Furthermore	furthermore	RB
cord-301755-fxfsr9bj	219	2	,	,	,
cord-301755-fxfsr9bj	219	3	the	the	DT
cord-301755-fxfsr9bj	219	4	sequence	sequence	NN
cord-301755-fxfsr9bj	219	5	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	219	6	was	be	VBD
cord-301755-fxfsr9bj	219	7	located	locate	VBN
cord-301755-fxfsr9bj	219	8	mostly	mostly	RB
cord-301755-fxfsr9bj	219	9	in	in	IN
cord-301755-fxfsr9bj	219	10	the	the	DT
cord-301755-fxfsr9bj	219	11	Sl	Sl	NNP
cord-301755-fxfsr9bj	219	12	hypervariable	hypervariable	NN
cord-301755-fxfsr9bj	219	13	region	region	NN
cord-301755-fxfsr9bj	220	1	(	(	-LRB-
cord-301755-fxfsr9bj	220	2	Banner	Banner	NNP
cord-301755-fxfsr9bj	220	3	et	et	NNP
cord-301755-fxfsr9bj	220	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	220	5	,	,	,
cord-301755-fxfsr9bj	220	6	1990	1990	CD
cord-301755-fxfsr9bj	220	7	;	;	:
cord-301755-fxfsr9bj	220	8	de	de	NNP
cord-301755-fxfsr9bj	220	9	Groot	Groot	NNP
cord-301755-fxfsr9bj	220	10	et	et	NNP
cord-301755-fxfsr9bj	220	11	a/.	a/.	NNP
cord-301755-fxfsr9bj	220	12	,	,	,
cord-301755-fxfsr9bj	220	13	1987	1987	CD
cord-301755-fxfsr9bj	220	14	)	)	-RRB-
cord-301755-fxfsr9bj	220	15	,	,	.
cord-301755-fxfsr9bj	221	1	suggesting	suggest	VBG
cord-301755-fxfsr9bj	221	2	that	that	IN
cord-301755-fxfsr9bj	221	3	the	the	DT
cord-301755-fxfsr9bj	221	4	observed	observed	JJ
cord-301755-fxfsr9bj	221	5	sequence	sequence	NN
cord-301755-fxfsr9bj	221	6	variations	variation	NNS
cord-301755-fxfsr9bj	221	7	represented	represent	VBD
cord-301755-fxfsr9bj	221	8	variations	variation	NNS
cord-301755-fxfsr9bj	221	9	in	in	IN
cord-301755-fxfsr9bj	221	10	the	the	DT
cord-301755-fxfsr9bj	221	11	RNA	RNA	NNP
cord-301755-fxfsr9bj	221	12	.	.	.
cord-301755-fxfsr9bj	222	1	Since	since	IN
cord-301755-fxfsr9bj	222	2	the	the	DT
cord-301755-fxfsr9bj	222	3	plaque	plaque	NN
cord-301755-fxfsr9bj	222	4	-	-	HYPH
cord-301755-fxfsr9bj	222	5	purified	purify	VBN
cord-301755-fxfsr9bj	222	6	viruses	virus	NNS
cord-301755-fxfsr9bj	222	7	need	need	VBP
cord-301755-fxfsr9bj	222	8	to	to	TO
cord-301755-fxfsr9bj	222	9	be	be	VB
cord-301755-fxfsr9bj	222	10	propagated	propagate	VBN
cord-301755-fxfsr9bj	222	11	for	for	IN
cord-301755-fxfsr9bj	222	12	either	either	CC
cord-301755-fxfsr9bj	222	13	biochemical	biochemical	JJ
cord-301755-fxfsr9bj	222	14	or	or	CC
cord-301755-fxfsr9bj	222	15	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	222	16	studies	study	NNS
cord-301755-fxfsr9bj	222	17	,	,	,
cord-301755-fxfsr9bj	222	18	this	this	DT
cord-301755-fxfsr9bj	222	19	sequence	sequence	NN
cord-301755-fxfsr9bj	222	20	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	222	21	is	be	VBZ
cord-301755-fxfsr9bj	222	22	likely	likely	RB
cord-301755-fxfsr9bj	222	23	an	an	DT
cord-301755-fxfsr9bj	222	24	inherent	inherent	JJ
cord-301755-fxfsr9bj	222	25	property	property	NN
cord-301755-fxfsr9bj	222	26	of	of	IN
cord-301755-fxfsr9bj	222	27	any	any	DT
cord-301755-fxfsr9bj	222	28	virus	virus	NN
cord-301755-fxfsr9bj	222	29	population	population	NN
cord-301755-fxfsr9bj	222	30	.	.	.
cord-301755-fxfsr9bj	223	1	The	the	DT
cord-301755-fxfsr9bj	223	2	possible	possible	JJ
cord-301755-fxfsr9bj	223	3	contribution	contribution	NN
cord-301755-fxfsr9bj	223	4	of	of	IN
cord-301755-fxfsr9bj	223	5	the	the	DT
cord-301755-fxfsr9bj	223	6	sequence	sequence	NN
cord-301755-fxfsr9bj	223	7	microheterogeneity	microheterogeneity	NN
cord-301755-fxfsr9bj	223	8	to	to	IN
cord-301755-fxfsr9bj	223	9	viral	viral	JJ
cord-301755-fxfsr9bj	223	10	neuropathogenicity	neuropathogenicity	NN
cord-301755-fxfsr9bj	223	11	is	be	VBZ
cord-301755-fxfsr9bj	223	12	not	not	RB
cord-301755-fxfsr9bj	223	13	clear	clear	JJ
cord-301755-fxfsr9bj	223	14	at	at	IN
cord-301755-fxfsr9bj	223	15	the	the	DT
cord-301755-fxfsr9bj	223	16	present	present	JJ
cord-301755-fxfsr9bj	223	17	time	time	NN
cord-301755-fxfsr9bj	223	18	.	.	.
cord-301755-fxfsr9bj	224	1	In	in	IN
cord-301755-fxfsr9bj	224	2	conclusion	conclusion	NN
cord-301755-fxfsr9bj	224	3	,	,	,
cord-301755-fxfsr9bj	224	4	our	-PRON-	PRP$
cord-301755-fxfsr9bj	224	5	studies	study	NNS
cord-301755-fxfsr9bj	224	6	suggest	suggest	VBP
cord-301755-fxfsr9bj	224	7	that	that	IN
cord-301755-fxfsr9bj	224	8	at	at	RB
cord-301755-fxfsr9bj	224	9	least	least	RBS
cord-301755-fxfsr9bj	224	10	two	two	CD
cord-301755-fxfsr9bj	224	11	regions	region	NNS
cord-301755-fxfsr9bj	224	12	of	of	IN
cord-301755-fxfsr9bj	224	13	the	the	DT
cord-301755-fxfsr9bj	224	14	S	S	NNP
cord-301755-fxfsr9bj	224	15	gene	gene	NN
cord-301755-fxfsr9bj	224	16	play	play	VBP
cord-301755-fxfsr9bj	224	17	critical	critical	JJ
cord-301755-fxfsr9bj	224	18	roles	role	NNS
cord-301755-fxfsr9bj	224	19	in	in	IN
cord-301755-fxfsr9bj	224	20	JHM	JHM	NNP
cord-301755-fxfsr9bj	224	21	neuropathogenesis	neuropathogenesis	NNP
cord-301755-fxfsr9bj	224	22	.	.	.
cord-301755-fxfsr9bj	225	1	These	these	DT
cord-301755-fxfsr9bj	225	2	regions	region	NNS
cord-301755-fxfsr9bj	225	3	are	be	VBP
cord-301755-fxfsr9bj	225	4	near	near	IN
cord-301755-fxfsr9bj	225	5	NT	NT	NNP
cord-301755-fxfsr9bj	225	6	1500-l	1500-l	CD
cord-301755-fxfsr9bj	225	7	950	950	CD
cord-301755-fxfsr9bj	225	8	(	(	-LRB-
cord-301755-fxfsr9bj	225	9	Sl	sl	NN
cord-301755-fxfsr9bj	225	10	segment	segment	NN
cord-301755-fxfsr9bj	225	11	)	)	-RRB-
cord-301755-fxfsr9bj	225	12	and	and	CC
cord-301755-fxfsr9bj	225	13	NT	NT	NNP
cord-301755-fxfsr9bj	225	14	3340	3340	CD
cord-301755-fxfsr9bj	225	15	(	(	-LRB-
cord-301755-fxfsr9bj	225	16	S2	s2	NN
cord-301755-fxfsr9bj	225	17	segment	segment	NN
cord-301755-fxfsr9bj	225	18	)	)	-RRB-
cord-301755-fxfsr9bj	225	19	.	.	.
cord-301755-fxfsr9bj	226	1	Antigenic	antigenic	JJ
cord-301755-fxfsr9bj	226	2	studies	study	NNS
cord-301755-fxfsr9bj	226	3	indicate	indicate	VBP
cord-301755-fxfsr9bj	226	4	that	that	IN
cord-301755-fxfsr9bj	226	5	these	these	DT
cord-301755-fxfsr9bj	226	6	sites	site	NNS
cord-301755-fxfsr9bj	226	7	may	may	MD
cord-301755-fxfsr9bj	226	8	be	be	VB
cord-301755-fxfsr9bj	226	9	closely	closely	RB
cord-301755-fxfsr9bj	226	10	linked	link	VBN
cord-301755-fxfsr9bj	226	11	on	on	IN
cord-301755-fxfsr9bj	226	12	the	the	DT
cord-301755-fxfsr9bj	226	13	S	S	NNP
cord-301755-fxfsr9bj	226	14	protein	protein	NN
cord-301755-fxfsr9bj	226	15	and	and	CC
cord-301755-fxfsr9bj	226	16	may	may	MD
cord-301755-fxfsr9bj	226	17	influence	influence	VB
cord-301755-fxfsr9bj	226	18	each	each	DT
cord-301755-fxfsr9bj	226	19	other	other	JJ
cord-301755-fxfsr9bj	226	20	by	by	IN
cord-301755-fxfsr9bj	226	21	spatial	spatial	JJ
cord-301755-fxfsr9bj	226	22	proximity	proximity	NN
cord-301755-fxfsr9bj	226	23	or	or	CC
cord-301755-fxfsr9bj	226	24	steric	steric	JJ
cord-301755-fxfsr9bj	226	25	effects	effect	NNS
cord-301755-fxfsr9bj	226	26	(	(	-LRB-
cord-301755-fxfsr9bj	226	27	Fleming	Fleming	NNP
cord-301755-fxfsr9bj	226	28	et	et	NNP
cord-301755-fxfsr9bj	226	29	al	al	NNP
cord-301755-fxfsr9bj	226	30	.	.	NNP
cord-301755-fxfsr9bj	226	31	,	,	,
cord-301755-fxfsr9bj	226	32	1986	1986	CD
cord-301755-fxfsr9bj	226	33	)	)	-RRB-
cord-301755-fxfsr9bj	226	34	.	.	.
cord-301755-fxfsr9bj	227	1	Viruses	virus	NNS
cord-301755-fxfsr9bj	227	2	with	with	IN
cord-301755-fxfsr9bj	227	3	the	the	DT
cord-301755-fxfsr9bj	227	4	parental	parental	JJ
cord-301755-fxfsr9bj	227	5	JHM	JHM	NNP
cord-301755-fxfsr9bj	227	6	sequences	sequence	NNS
cord-301755-fxfsr9bj	227	7	may	may	MD
cord-301755-fxfsr9bj	227	8	infect	infect	VB
cord-301755-fxfsr9bj	227	9	all	all	DT
cord-301755-fxfsr9bj	227	10	cell	cell	NN
cord-301755-fxfsr9bj	227	11	types	type	NNS
cord-301755-fxfsr9bj	227	12	and	and	CC
cord-301755-fxfsr9bj	227	13	regions	region	NNS
cord-301755-fxfsr9bj	227	14	of	of	IN
cord-301755-fxfsr9bj	227	15	the	the	DT
cord-301755-fxfsr9bj	227	16	CNS	CNS	NNP
cord-301755-fxfsr9bj	227	17	,	,	,
cord-301755-fxfsr9bj	227	18	resulting	result	VBG
cord-301755-fxfsr9bj	227	19	in	in	IN
cord-301755-fxfsr9bj	227	20	fatal	fatal	JJ
cord-301755-fxfsr9bj	227	21	panencephalitis	panencephalitis	NN
cord-301755-fxfsr9bj	227	22	.	.	.
cord-301755-fxfsr9bj	228	1	When	when	WRB
cord-301755-fxfsr9bj	228	2	either	either	DT
cord-301755-fxfsr9bj	228	3	site	site	NN
cord-301755-fxfsr9bj	228	4	is	be	VBZ
cord-301755-fxfsr9bj	228	5	altered	alter	VBN
cord-301755-fxfsr9bj	228	6	,	,	,
cord-301755-fxfsr9bj	228	7	viral	viral	JJ
cord-301755-fxfsr9bj	228	8	infection	infection	NN
cord-301755-fxfsr9bj	228	9	is	be	VBZ
cord-301755-fxfsr9bj	228	10	limited	limit	VBN
cord-301755-fxfsr9bj	228	11	to	to	IN
cord-301755-fxfsr9bj	228	12	glial	glial	JJ
cord-301755-fxfsr9bj	228	13	cells	cell	NNS
cord-301755-fxfsr9bj	228	14	of	of	IN
cord-301755-fxfsr9bj	228	15	the	the	DT
cord-301755-fxfsr9bj	228	16	white	white	JJ
cord-301755-fxfsr9bj	228	17	matter	matter	NN
cord-301755-fxfsr9bj	228	18	,	,	,
cord-301755-fxfsr9bj	228	19	and	and	CC
cord-301755-fxfsr9bj	228	20	subsequent	subsequent	JJ
cord-301755-fxfsr9bj	228	21	immune	immune	JJ
cord-301755-fxfsr9bj	228	22	attack	attack	NN
cord-301755-fxfsr9bj	228	23	(	(	-LRB-
cord-301755-fxfsr9bj	228	24	Wang	Wang	NNP
cord-301755-fxfsr9bj	228	25	et	et	NNP
cord-301755-fxfsr9bj	228	26	al	al	NNP
cord-301755-fxfsr9bj	228	27	.	.	NNP
cord-301755-fxfsr9bj	228	28	,	,	,
cord-301755-fxfsr9bj	228	29	1990	1990	CD
cord-301755-fxfsr9bj	228	30	)	)	-RRB-
cord-301755-fxfsr9bj	228	31	or	or	CC
cord-301755-fxfsr9bj	228	32	virus	virus	NN
cord-301755-fxfsr9bj	228	33	-	-	HYPH
cord-301755-fxfsr9bj	228	34	induced	induce	VBN
cord-301755-fxfsr9bj	228	35	cytolysis	cytolysis	NN
cord-301755-fxfsr9bj	228	36	will	will	MD
cord-301755-fxfsr9bj	228	37	lead	lead	VB
cord-301755-fxfsr9bj	228	38	to	to	IN
cord-301755-fxfsr9bj	228	39	demyelination	demyelination	NN
cord-301755-fxfsr9bj	228	40	.	.	.
cord-301755-fxfsr9bj	229	1	When	when	WRB
cord-301755-fxfsr9bj	229	2	both	both	DT
cord-301755-fxfsr9bj	229	3	sites	site	NNS
cord-301755-fxfsr9bj	229	4	are	be	VBP
cord-301755-fxfsr9bj	229	5	affected	affect	VBN
cord-301755-fxfsr9bj	229	6	,	,	,
cord-301755-fxfsr9bj	229	7	the	the	DT
cord-301755-fxfsr9bj	229	8	virus	virus	NN
cord-301755-fxfsr9bj	229	9	shows	show	VBZ
cord-301755-fxfsr9bj	229	10	very	very	RB
cord-301755-fxfsr9bj	229	11	limited	limited	JJ
cord-301755-fxfsr9bj	229	12	distribution	distribution	NN
cord-301755-fxfsr9bj	229	13	and	and	CC
cord-301755-fxfsr9bj	229	14	presumably	presumably	RB
cord-301755-fxfsr9bj	229	15	is	be	VBZ
cord-301755-fxfsr9bj	229	16	contained	contain	VBN
cord-301755-fxfsr9bj	229	17	by	by	IN
cord-301755-fxfsr9bj	229	18	the	the	DT
cord-301755-fxfsr9bj	229	19	immune	immune	JJ
cord-301755-fxfsr9bj	229	20	system	system	NN
cord-301755-fxfsr9bj	229	21	at	at	IN
cord-301755-fxfsr9bj	229	22	an	an	DT
cord-301755-fxfsr9bj	229	23	early	early	JJ
cord-301755-fxfsr9bj	229	24	stage	stage	NN
cord-301755-fxfsr9bj	229	25	of	of	IN
cord-301755-fxfsr9bj	229	26	pathogenesis	pathogenesis	NN
cord-301755-fxfsr9bj	229	27	.	.	.
cord-301755-fxfsr9bj	230	1	It	-PRON-	PRP
cord-301755-fxfsr9bj	230	2	is	be	VBZ
cord-301755-fxfsr9bj	230	3	probable	probable	JJ
cord-301755-fxfsr9bj	230	4	that	that	IN
cord-301755-fxfsr9bj	230	5	other	other	JJ
cord-301755-fxfsr9bj	230	6	S	S	NNP
cord-301755-fxfsr9bj	230	7	domains	domain	NNS
cord-301755-fxfsr9bj	230	8	may	may	MD
cord-301755-fxfsr9bj	230	9	also	also	RB
cord-301755-fxfsr9bj	230	10	contribute	contribute	VB
cord-301755-fxfsr9bj	230	11	to	to	IN
cord-301755-fxfsr9bj	230	12	the	the	DT
cord-301755-fxfsr9bj	230	13	viral	viral	JJ
cord-301755-fxfsr9bj	230	14	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	230	15	.	.	.
cord-301755-fxfsr9bj	231	1	In	in	IN
cord-301755-fxfsr9bj	231	2	addition	addition	NN
cord-301755-fxfsr9bj	231	3	,	,	,
cord-301755-fxfsr9bj	231	4	although	although	IN
cord-301755-fxfsr9bj	231	5	the	the	DT
cord-301755-fxfsr9bj	231	6	S	S	NNP
cord-301755-fxfsr9bj	231	7	gene	gene	NN
cord-301755-fxfsr9bj	231	8	is	be	VBZ
cord-301755-fxfsr9bj	231	9	considered	consider	VBN
cord-301755-fxfsr9bj	231	10	to	to	TO
cord-301755-fxfsr9bj	231	11	be	be	VB
cord-301755-fxfsr9bj	231	12	the	the	DT
cord-301755-fxfsr9bj	231	13	most	most	RBS
cord-301755-fxfsr9bj	231	14	important	important	JJ
cord-301755-fxfsr9bj	231	15	in	in	IN
cord-301755-fxfsr9bj	231	16	influencing	influence	VBG
cord-301755-fxfsr9bj	231	17	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	231	18	,	,	,
cord-301755-fxfsr9bj	231	19	other	other	JJ
cord-301755-fxfsr9bj	231	20	viral	viral	JJ
cord-301755-fxfsr9bj	231	21	genes	gene	NNS
cord-301755-fxfsr9bj	231	22	such	such	JJ
cord-301755-fxfsr9bj	231	23	as	as	IN
cord-301755-fxfsr9bj	231	24	hemagglutinin	hemagglutinin	NN
cord-301755-fxfsr9bj	231	25	-	-	HYPH
cord-301755-fxfsr9bj	231	26	esterase	esterase	NN
cord-301755-fxfsr9bj	231	27	(	(	-LRB-
cord-301755-fxfsr9bj	231	28	HE	he	NN
cord-301755-fxfsr9bj	231	29	)	)	-RRB-
cord-301755-fxfsr9bj	231	30	(	(	-LRB-
cord-301755-fxfsr9bj	232	1	La	La	NNP
cord-301755-fxfsr9bj	232	2	Monica	Monica	NNP
cord-301755-fxfsr9bj	232	3	et	et	NNP
cord-301755-fxfsr9bj	232	4	a/.	a/.	NNP
cord-301755-fxfsr9bj	232	5	,	,	,
cord-301755-fxfsr9bj	232	6	1991	1991	CD
cord-301755-fxfsr9bj	232	7	,	,	,
cord-301755-fxfsr9bj	232	8	Yokomori	Yokomori	NNP
cord-301755-fxfsr9bj	232	9	et	et	NNP
cord-301755-fxfsr9bj	232	10	al	al	NNP
cord-301755-fxfsr9bj	232	11	.	.	NNP
cord-301755-fxfsr9bj	232	12	,	,	,
cord-301755-fxfsr9bj	232	13	1991	1991	CD
cord-301755-fxfsr9bj	232	14	)	)	-RRB-
cord-301755-fxfsr9bj	232	15	and	and	CC
cord-301755-fxfsr9bj	232	16	those	those	DT
cord-301755-fxfsr9bj	232	17	localized	localize	VBN
cord-301755-fxfsr9bj	232	18	to	to	IN
cord-301755-fxfsr9bj	232	19	the	the	DT
cord-301755-fxfsr9bj	232	20	3	3	CD
cord-301755-fxfsr9bj	232	21	'	'	POS
cord-301755-fxfsr9bj	232	22	portion	portion	NN
cord-301755-fxfsr9bj	232	23	of	of	IN
cord-301755-fxfsr9bj	232	24	the	the	DT
cord-301755-fxfsr9bj	232	25	genome	genome	NN
cord-301755-fxfsr9bj	233	1	(	(	-LRB-
cord-301755-fxfsr9bj	233	2	Lavi	Lavi	NNP
cord-301755-fxfsr9bj	233	3	et	et	NNP
cord-301755-fxfsr9bj	233	4	a/.	a/.	NN
cord-301755-fxfsr9bj	233	5	,	,	,
cord-301755-fxfsr9bj	233	6	1990	1990	CD
cord-301755-fxfsr9bj	233	7	)	)	-RRB-
cord-301755-fxfsr9bj	233	8	may	may	MD
cord-301755-fxfsr9bj	233	9	also	also	RB
cord-301755-fxfsr9bj	233	10	,	,	,
cord-301755-fxfsr9bj	233	11	to	to	IN
cord-301755-fxfsr9bj	233	12	some	some	DT
cord-301755-fxfsr9bj	233	13	extent	extent	NN
cord-301755-fxfsr9bj	233	14	,	,	,
cord-301755-fxfsr9bj	233	15	contribute	contribute	VB
cord-301755-fxfsr9bj	233	16	to	to	IN
cord-301755-fxfsr9bj	233	17	viral	viral	JJ
cord-301755-fxfsr9bj	233	18	pathogenicity	pathogenicity	NN
cord-301755-fxfsr9bj	233	19	.	.	.
cord-301755-fxfsr9bj	234	1	A	a	DT
cord-301755-fxfsr9bj	234	2	clustering	clustering	NN
cord-301755-fxfsr9bj	234	3	of	of	IN
cord-301755-fxfsr9bj	234	4	RNA	RNA	NNP
cord-301755-fxfsr9bj	234	5	recombination	recombination	NN
cord-301755-fxfsr9bj	234	6	sites	site	NNS
cord-301755-fxfsr9bj	234	7	adjacent	adjacent	JJ
cord-301755-fxfsr9bj	234	8	to	to	IN
cord-301755-fxfsr9bj	234	9	a	a	DT
cord-301755-fxfsr9bj	234	10	hypervariable	hypervariable	JJ
cord-301755-fxfsr9bj	234	11	region	region	NN
cord-301755-fxfsr9bj	234	12	of	of	IN
cord-301755-fxfsr9bj	234	13	the	the	DT
cord-301755-fxfsr9bj	234	14	peplomer	peplomer	JJ
cord-301755-fxfsr9bj	234	15	gene	gene	NN
cord-301755-fxfsr9bj	234	16	of	of	IN
cord-301755-fxfsr9bj	234	17	murine	murine	JJ
cord-301755-fxfsr9bj	234	18	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	235	1	Murine	murine	JJ
cord-301755-fxfsr9bj	235	2	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	235	3	virus-4	virus-4	NNP
cord-301755-fxfsr9bj	236	1	(	(	-LRB-
cord-301755-fxfsr9bj	236	2	strain	strain	NN
cord-301755-fxfsr9bj	236	3	JHM	JHM	NNP
cord-301755-fxfsr9bj	236	4	)	)	-RRB-
cord-301755-fxfsr9bj	236	5	induced	induce	VBN
cord-301755-fxfsr9bj	236	6	neurologic	neurologic	JJ
cord-301755-fxfsr9bj	236	7	disease	disease	NN
cord-301755-fxfsr9bj	236	8	is	be	VBZ
cord-301755-fxfsr9bj	236	9	modulated	modulate	VBN
cord-301755-fxfsr9bj	236	10	in	in	IN
cord-301755-fxfsr9bj	236	11	viva	viva	FW
cord-301755-fxfsr9bj	236	12	by	by	IN
cord-301755-fxfsr9bj	236	13	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	236	14	antibody	antibody	NN
cord-301755-fxfsr9bj	236	15	.	.	.
cord-301755-fxfsr9bj	237	1	I	I	NNP
cord-301755-fxfsr9bj	237	2	/	/	SYM
cord-301755-fxfsr9bj	237	3	iro	iro	NNP
cord-301755-fxfsr9bj	237	4	/	/	SYM
cord-301755-fxfsr9bj	237	5	ogy	ogy	NNP
cord-301755-fxfsr9bj	237	6	Monoclonal	Monoclonal	NNP
cord-301755-fxfsr9bj	237	7	antibodies	antibody	NNS
cord-301755-fxfsr9bj	237	8	to	to	IN
cord-301755-fxfsr9bj	237	9	murine	murine	JJ
cord-301755-fxfsr9bj	237	10	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	237	11	virus-4	virus-4	NNP
cord-301755-fxfsr9bj	238	1	(	(	-LRB-
cord-301755-fxfsr9bj	238	2	strain	strain	NN
cord-301755-fxfsr9bj	238	3	JHM	JHM	NNP
cord-301755-fxfsr9bj	238	4	)	)	-RRB-
cord-301755-fxfsr9bj	238	5	define	define	VB
cord-301755-fxfsr9bj	238	6	the	the	DT
cord-301755-fxfsr9bj	238	7	viral	viral	JJ
cord-301755-fxfsr9bj	238	8	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	238	9	responsible	responsible	JJ
cord-301755-fxfsr9bj	238	10	for	for	IN
cord-301755-fxfsr9bj	238	11	attachment	attachment	NN
cord-301755-fxfsr9bj	238	12	and	and	CC
cord-301755-fxfsr9bj	238	13	cell	cell	NN
cord-301755-fxfsr9bj	238	14	-	-	HYPH
cord-301755-fxfsr9bj	238	15	cell	cell	NN
cord-301755-fxfsr9bj	238	16	fusion	fusion	NN
cord-301755-fxfsr9bj	238	17	Site	site	NN
cord-301755-fxfsr9bj	238	18	-	-	HYPH
cord-301755-fxfsr9bj	238	19	specific	specific	JJ
cord-301755-fxfsr9bj	238	20	alteration	alteration	NN
cord-301755-fxfsr9bj	238	21	of	of	IN
cord-301755-fxfsr9bj	238	22	murine	murine	JJ
cord-301755-fxfsr9bj	238	23	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	238	24	virus	virus	NN
cord-301755-fxfsr9bj	238	25	type	type	NN
cord-301755-fxfsr9bj	238	26	4	4	CD
cord-301755-fxfsr9bj	238	27	peplomer	peplomer	NN
cord-301755-fxfsr9bj	238	28	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	238	29	E2	E2	NNP
cord-301755-fxfsr9bj	238	30	results	result	NNS
cord-301755-fxfsr9bj	238	31	in	in	IN
cord-301755-fxfsr9bj	238	32	reduced	reduce	VBN
cord-301755-fxfsr9bj	238	33	neurovirulence	neurovirulence	NN
cord-301755-fxfsr9bj	238	34	Evidence	evidence	NN
cord-301755-fxfsr9bj	238	35	for	for	IN
cord-301755-fxfsr9bj	238	36	a	a	DT
cord-301755-fxfsr9bj	238	37	coiled	coil	VBN
cord-301755-fxfsr9bj	238	38	-	-	HYPH
cord-301755-fxfsr9bj	238	39	coil	coil	NN
cord-301755-fxfsr9bj	238	40	structure	structure	NN
cord-301755-fxfsr9bj	238	41	in	in	IN
cord-301755-fxfsr9bj	238	42	the	the	DT
cord-301755-fxfsr9bj	238	43	spike	spike	NN
cord-301755-fxfsr9bj	238	44	proteins	protein	NNS
cord-301755-fxfsr9bj	238	45	of	of	IN
cord-301755-fxfsr9bj	238	46	coronaviruses	coronaviruse	NNS
cord-301755-fxfsr9bj	238	47	.	.	.
cord-301755-fxfsr9bj	239	1	1	1	CD
cord-301755-fxfsr9bj	239	2	Monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	239	3	antibodies	antibody	NNS
cord-301755-fxfsr9bj	239	4	to	to	IN
cord-301755-fxfsr9bj	239	5	the	the	DT
cord-301755-fxfsr9bj	239	6	matrix	matrix	NN
cord-301755-fxfsr9bj	239	7	(	(	-LRB-
cord-301755-fxfsr9bj	239	8	El	El	NNP
cord-301755-fxfsr9bj	239	9	)	)	-RRB-
cord-301755-fxfsr9bj	239	10	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	239	11	of	of	IN
cord-301755-fxfsr9bj	239	12	mouse	mouse	NNP
cord-301755-fxfsr9bj	239	13	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	239	14	virus	virus	NN
cord-301755-fxfsr9bj	239	15	protect	protect	VBP
cord-301755-fxfsr9bj	239	16	mice	mouse	NNS
cord-301755-fxfsr9bj	239	17	from	from	IN
cord-301755-fxfsr9bj	239	18	encephalitis	encephalitis	JJ
cord-301755-fxfsr9bj	239	19	Antigenic	antigenic	JJ
cord-301755-fxfsr9bj	239	20	relationships	relationship	NNS
cord-301755-fxfsr9bj	239	21	of	of	IN
cord-301755-fxfsr9bj	239	22	murine	murine	JJ
cord-301755-fxfsr9bj	239	23	coronaviruses	coronaviruse	NNS
cord-301755-fxfsr9bj	239	24	:	:	:
cord-301755-fxfsr9bj	239	25	Analysis	analysis	NN
cord-301755-fxfsr9bj	239	26	using	use	VBG
cord-301755-fxfsr9bj	239	27	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	239	28	antibodies	antibody	NNS
cord-301755-fxfsr9bj	239	29	to	to	IN
cord-301755-fxfsr9bj	240	1	JHM	JHM	NNP
cord-301755-fxfsr9bj	240	2	(	(	-LRB-
cord-301755-fxfsr9bj	240	3	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	240	4	)	)	-RRB-
cord-301755-fxfsr9bj	240	5	virus	virus	NN
cord-301755-fxfsr9bj	240	6	Pathogenicity	Pathogenicity	NNP
cord-301755-fxfsr9bj	240	7	of	of	IN
cord-301755-fxfsr9bj	240	8	antigenic	antigenic	JJ
cord-301755-fxfsr9bj	240	9	variants	variant	NNS
cord-301755-fxfsr9bj	240	10	of	of	IN
cord-301755-fxfsr9bj	240	11	murine	murine	JJ
cord-301755-fxfsr9bj	240	12	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	240	13	JHM	JHM	NNP
cord-301755-fxfsr9bj	240	14	selected	select	VBN
cord-301755-fxfsr9bj	240	15	with	with	IN
cord-301755-fxfsr9bj	240	16	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	240	17	antibodies	antibody	NNS
cord-301755-fxfsr9bj	240	18	Experimental	experimental	JJ
cord-301755-fxfsr9bj	240	19	demyelination	demyelination	NN
cord-301755-fxfsr9bj	240	20	induced	induce	VBN
cord-301755-fxfsr9bj	240	21	by	by	IN
cord-301755-fxfsr9bj	240	22	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	240	23	JHM	JHM	NNP
cord-301755-fxfsr9bj	240	24	(	(	-LRB-
cord-301755-fxfsr9bj	240	25	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	240	26	)	)	-RRB-
cord-301755-fxfsr9bj	241	1	:	:	:
cord-301755-fxfsr9bj	241	2	Molecular	molecular	JJ
cord-301755-fxfsr9bj	241	3	identification	identification	NN
cord-301755-fxfsr9bj	241	4	of	of	IN
cord-301755-fxfsr9bj	241	5	a	a	DT
cord-301755-fxfsr9bj	241	6	viral	viral	JJ
cord-301755-fxfsr9bj	241	7	determinant	determinant	NN
cord-301755-fxfsr9bj	241	8	of	of	IN
cord-301755-fxfsr9bj	241	9	paralytic	paralytic	JJ
cord-301755-fxfsr9bj	241	10	disease	disease	NN
cord-301755-fxfsr9bj	241	11	Alteration	Alteration	NNP
cord-301755-fxfsr9bj	241	12	of	of	IN
cord-301755-fxfsr9bj	241	13	the	the	DT
cord-301755-fxfsr9bj	241	14	pH	pH	NNP
cord-301755-fxfsr9bj	241	15	dependence	dependence	NN
cord-301755-fxfsr9bj	241	16	of	of	IN
cord-301755-fxfsr9bj	241	17	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	241	18	-	-	HYPH
cord-301755-fxfsr9bj	241	19	induced	induce	VBN
cord-301755-fxfsr9bj	241	20	cell	cell	NN
cord-301755-fxfsr9bj	241	21	fusion	fusion	NN
cord-301755-fxfsr9bj	241	22	:	:	:
cord-301755-fxfsr9bj	242	1	Effect	effect	NN
cord-301755-fxfsr9bj	242	2	of	of	IN
cord-301755-fxfsr9bj	242	3	mutations	mutation	NNS
cord-301755-fxfsr9bj	242	4	in	in	IN
cord-301755-fxfsr9bj	242	5	the	the	DT
cord-301755-fxfsr9bj	242	6	spike	spike	NN
cord-301755-fxfsr9bj	242	7	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	242	8	Neutralization	neutralization	NN
cord-301755-fxfsr9bj	242	9	-	-	HYPH
cord-301755-fxfsr9bj	242	10	resistant	resistant	JJ
cord-301755-fxfsr9bj	242	11	variants	variant	NNS
cord-301755-fxfsr9bj	242	12	of	of	IN
cord-301755-fxfsr9bj	242	13	a	a	DT
cord-301755-fxfsr9bj	242	14	neurotropic	neurotropic	NNP
cord-301755-fxfsr9bj	242	15	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	242	16	are	be	VBP
cord-301755-fxfsr9bj	242	17	generated	generate	VBN
cord-301755-fxfsr9bj	242	18	by	by	IN
cord-301755-fxfsr9bj	242	19	deletions	deletion	NNS
cord-301755-fxfsr9bj	242	20	within	within	IN
cord-301755-fxfsr9bj	242	21	the	the	DT
cord-301755-fxfsr9bj	242	22	amino	amino	NN
cord-301755-fxfsr9bj	242	23	-	-	HYPH
cord-301755-fxfsr9bj	242	24	terminal	terminal	NN
cord-301755-fxfsr9bj	242	25	half	half	NN
cord-301755-fxfsr9bj	242	26	of	of	IN
cord-301755-fxfsr9bj	242	27	the	the	DT
cord-301755-fxfsr9bj	242	28	spike	spike	NN
cord-301755-fxfsr9bj	242	29	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	242	30	.	.	.
cord-301755-fxfsr9bj	243	1	1	1	LS
cord-301755-fxfsr9bj	243	2	.	.	.
cord-301755-fxfsr9bj	244	1	viral	viral	JJ
cord-301755-fxfsr9bj	244	2	Replication	replication	NN
cord-301755-fxfsr9bj	244	3	and	and	CC
cord-301755-fxfsr9bj	244	4	plaque	plaque	NN
cord-301755-fxfsr9bj	244	5	formation	formation	NN
cord-301755-fxfsr9bj	244	6	of	of	IN
cord-301755-fxfsr9bj	244	7	mouse	mouse	NNP
cord-301755-fxfsr9bj	244	8	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	244	9	virus	virus	NN
cord-301755-fxfsr9bj	244	10	(	(	-LRB-
cord-301755-fxfsr9bj	244	11	MHV-2	mhv-2	NN
cord-301755-fxfsr9bj	244	12	)	)	-RRB-
cord-301755-fxfsr9bj	245	1	in	in	IN
cord-301755-fxfsr9bj	245	2	mouse	mouse	NN
cord-301755-fxfsr9bj	245	3	cell	cell	NN
cord-301755-fxfsr9bj	245	4	line	line	NN
cord-301755-fxfsr9bj	245	5	DBT	DBT	NNP
cord-301755-fxfsr9bj	245	6	culture	culture	NN
cord-301755-fxfsr9bj	245	7	Mouse	Mouse	NNP
cord-301755-fxfsr9bj	245	8	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	245	9	virus	virus	NN
cord-301755-fxfsr9bj	245	10	type	type	NN
cord-301755-fxfsr9bj	245	11	4	4	CD
cord-301755-fxfsr9bj	246	1	(	(	-LRB-
cord-301755-fxfsr9bj	246	2	JHM	JHM	NNP
cord-301755-fxfsr9bj	246	3	strain)-induced	strain)-induced	NNP
cord-301755-fxfsr9bj	246	4	fatal	fatal	JJ
cord-301755-fxfsr9bj	246	5	central	central	JJ
cord-301755-fxfsr9bj	246	6	nervous	nervous	JJ
cord-301755-fxfsr9bj	246	7	system	system	NN
cord-301755-fxfsr9bj	246	8	disease	disease	NN
cord-301755-fxfsr9bj	246	9	.	.	.
cord-301755-fxfsr9bj	247	1	I.	I.	NNP
cord-301755-fxfsr9bj	247	2	Genetic	genetic	JJ
cord-301755-fxfsr9bj	247	3	control	control	NN
cord-301755-fxfsr9bj	247	4	and	and	CC
cord-301755-fxfsr9bj	247	5	the	the	DT
cord-301755-fxfsr9bj	247	6	murine	murine	JJ
cord-301755-fxfsr9bj	247	7	neuron	neuron	NN
cord-301755-fxfsr9bj	247	8	as	as	IN
cord-301755-fxfsr9bj	247	9	the	the	DT
cord-301755-fxfsr9bj	247	10	susceptible	susceptible	JJ
cord-301755-fxfsr9bj	247	11	site	site	NN
cord-301755-fxfsr9bj	247	12	of	of	IN
cord-301755-fxfsr9bj	247	13	disease	disease	NN
cord-301755-fxfsr9bj	247	14	Coronavirus	Coronavirus	NNP
cord-301755-fxfsr9bj	247	15	:	:	:
cord-301755-fxfsr9bj	247	16	Organization	organization	NN
cord-301755-fxfsr9bj	247	17	,	,	,
cord-301755-fxfsr9bj	247	18	replication	replication	NN
cord-301755-fxfsr9bj	247	19	and	and	CC
cord-301755-fxfsr9bj	247	20	expression	expression	NN
cord-301755-fxfsr9bj	247	21	of	of	IN
cord-301755-fxfsr9bj	247	22	genome	genome	NN
cord-301755-fxfsr9bj	247	23	RNA	RNA	NNP
cord-301755-fxfsr9bj	247	24	of	of	IN
cord-301755-fxfsr9bj	247	25	mouse	mouse	NNP
cord-301755-fxfsr9bj	247	26	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	247	27	virus	virus	NN
cord-301755-fxfsr9bj	247	28	Localization	Localization	NNP
cord-301755-fxfsr9bj	247	29	of	of	IN
cord-301755-fxfsr9bj	247	30	extensive	extensive	JJ
cord-301755-fxfsr9bj	247	31	deletions	deletion	NNS
cord-301755-fxfsr9bj	247	32	in	in	IN
cord-301755-fxfsr9bj	247	33	the	the	DT
cord-301755-fxfsr9bj	247	34	structural	structural	JJ
cord-301755-fxfsr9bj	247	35	genes	gene	NNS
cord-301755-fxfsr9bj	247	36	of	of	IN
cord-301755-fxfsr9bj	247	37	two	two	CD
cord-301755-fxfsr9bj	247	38	neurotropic	neurotropic	NNP
cord-301755-fxfsr9bj	247	39	variants	variant	NNS
cord-301755-fxfsr9bj	247	40	of	of	IN
cord-301755-fxfsr9bj	247	41	murine	murine	JJ
cord-301755-fxfsr9bj	247	42	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	247	43	JHM	JHM	NNP
cord-301755-fxfsr9bj	247	44	Determinants	Determinants	NNP
cord-301755-fxfsr9bj	247	45	of	of	IN
cord-301755-fxfsr9bj	247	46	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	247	47	MHV	MHV	NNP
cord-301755-fxfsr9bj	247	48	pathogenesis	pathogenesis	NN
cord-301755-fxfsr9bj	247	49	are	be	VBP
cord-301755-fxfsr9bj	247	50	localized	localize	VBN
cord-301755-fxfsr9bj	247	51	to	to	IN
cord-301755-fxfsr9bj	247	52	3	3	CD
cord-301755-fxfsr9bj	247	53	'	'	POS
cord-301755-fxfsr9bj	247	54	portions	portion	NNS
cord-301755-fxfsr9bj	247	55	of	of	IN
cord-301755-fxfsr9bj	247	56	the	the	DT
cord-301755-fxfsr9bj	247	57	genome	genome	NN
cord-301755-fxfsr9bj	247	58	as	as	IN
cord-301755-fxfsr9bj	247	59	determined	determine	VBN
cord-301755-fxfsr9bj	247	60	by	by	IN
cord-301755-fxfsr9bj	247	61	ribonucleic	ribonucleic	JJ
cord-301755-fxfsr9bj	247	62	acid	acid	NN
cord-301755-fxfsr9bj	247	63	-	-	HYPH
cord-301755-fxfsr9bj	247	64	ribonucleic	ribonucleic	NN
cord-301755-fxfsr9bj	247	65	acid	acid	NN
cord-301755-fxfsr9bj	247	66	recombination	recombination	NN
cord-301755-fxfsr9bj	248	1	The	the	DT
cord-301755-fxfsr9bj	248	2	complete	complete	JJ
cord-301755-fxfsr9bj	248	3	sequence	sequence	NN
cord-301755-fxfsr9bj	248	4	(	(	-LRB-
cord-301755-fxfsr9bj	248	5	22	22	CD
cord-301755-fxfsr9bj	248	6	kilobases	kilobase	NNS
cord-301755-fxfsr9bj	248	7	)	)	-RRB-
cord-301755-fxfsr9bj	248	8	of	of	IN
cord-301755-fxfsr9bj	248	9	murine	murine	JJ
cord-301755-fxfsr9bj	248	10	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	248	11	gene	gene	NN
cord-301755-fxfsr9bj	248	12	1	1	CD
cord-301755-fxfsr9bj	248	13	encoding	encode	VBG
cord-301755-fxfsr9bj	248	14	the	the	DT
cord-301755-fxfsr9bj	248	15	putative	putative	JJ
cord-301755-fxfsr9bj	248	16	proteases	protease	NNS
cord-301755-fxfsr9bj	248	17	and	and	CC
cord-301755-fxfsr9bj	248	18	RNA	RNA	NNP
cord-301755-fxfsr9bj	248	19	polymerase	polymerase	NN
cord-301755-fxfsr9bj	248	20	Amino	amino	NN
cord-301755-fxfsr9bj	248	21	acid	acid	NN
cord-301755-fxfsr9bj	248	22	sequence	sequence	NN
cord-301755-fxfsr9bj	248	23	of	of	IN
cord-301755-fxfsr9bj	248	24	a	a	DT
cord-301755-fxfsr9bj	248	25	conserved	conserve	VBN
cord-301755-fxfsr9bj	248	26	neutralizing	neutralize	VBG
cord-301755-fxfsr9bj	248	27	epitope	epitope	NN
cord-301755-fxfsr9bj	248	28	of	of	IN
cord-301755-fxfsr9bj	248	29	murine	murine	JJ
cord-301755-fxfsr9bj	248	30	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	248	31	Primary	primary	JJ
cord-301755-fxfsr9bj	248	32	structure	structure	NN
cord-301755-fxfsr9bj	248	33	of	of	IN
cord-301755-fxfsr9bj	248	34	the	the	DT
cord-301755-fxfsr9bj	248	35	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	248	36	E2	e2	NN
cord-301755-fxfsr9bj	248	37	of	of	IN
cord-301755-fxfsr9bj	248	38	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	248	39	MHV	MHV	NNP
cord-301755-fxfsr9bj	248	40	-	-	HYPH
cord-301755-fxfsr9bj	248	41	A59	A59	NNP
cord-301755-fxfsr9bj	248	42	and	and	CC
cord-301755-fxfsr9bj	248	43	identification	identification	NN
cord-301755-fxfsr9bj	248	44	of	of	IN
cord-301755-fxfsr9bj	248	45	the	the	DT
cord-301755-fxfsr9bj	248	46	trypsin	trypsin	NN
cord-301755-fxfsr9bj	248	47	cleavage	cleavage	NN
cord-301755-fxfsr9bj	248	48	site	site	NN
cord-301755-fxfsr9bj	248	49	Characterization	characterization	NN
cord-301755-fxfsr9bj	248	50	of	of	IN
cord-301755-fxfsr9bj	248	51	small	small	JJ
cord-301755-fxfsr9bj	248	52	plaque	plaque	NN
cord-301755-fxfsr9bj	248	53	mutants	mutant	NNS
cord-301755-fxfsr9bj	248	54	of	of	IN
cord-301755-fxfsr9bj	248	55	mouse	mouse	NN
cord-301755-fxfsr9bj	248	56	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	248	57	virus	virus	NN
cord-301755-fxfsr9bj	248	58	Protective	protective	JJ
cord-301755-fxfsr9bj	248	59	effect	effect	NN
cord-301755-fxfsr9bj	248	60	of	of	IN
cord-301755-fxfsr9bj	248	61	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	248	62	antibodies	antibody	NNS
cord-301755-fxfsr9bj	248	63	on	on	IN
cord-301755-fxfsr9bj	248	64	lethal	lethal	JJ
cord-301755-fxfsr9bj	248	65	mouse	mouse	NN
cord-301755-fxfsr9bj	248	66	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	248	67	virus	virus	NN
cord-301755-fxfsr9bj	248	68	infection	infection	NN
cord-301755-fxfsr9bj	248	69	in	in	IN
cord-301755-fxfsr9bj	248	70	mice	mouse	NNS
cord-301755-fxfsr9bj	249	1	Molecular	molecular	JJ
cord-301755-fxfsr9bj	249	2	cloning	cloning	NN
cord-301755-fxfsr9bj	249	3	of	of	IN
cord-301755-fxfsr9bj	249	4	the	the	DT
cord-301755-fxfsr9bj	249	5	gene	gene	NN
cord-301755-fxfsr9bj	249	6	encoding	encode	VBG
cord-301755-fxfsr9bj	249	7	the	the	DT
cord-301755-fxfsr9bj	249	8	putative	putative	JJ
cord-301755-fxfsr9bj	249	9	polymerase	polymerase	NN
cord-301755-fxfsr9bj	249	10	of	of	IN
cord-301755-fxfsr9bj	249	11	mouse	mouse	NN
cord-301755-fxfsr9bj	249	12	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	249	13	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	249	14	strain	strain	NN
cord-301755-fxfsr9bj	250	1	A59	A59	NNP
cord-301755-fxfsr9bj	250	2	Sequence	Sequence	NNP
cord-301755-fxfsr9bj	250	3	analysis	analysis	NN
cord-301755-fxfsr9bj	250	4	reveals	reveal	VBZ
cord-301755-fxfsr9bj	250	5	extensive	extensive	JJ
cord-301755-fxfsr9bj	250	6	polymorphism	polymorphism	NN
cord-301755-fxfsr9bj	250	7	and	and	CC
cord-301755-fxfsr9bj	250	8	evidence	evidence	NN
cord-301755-fxfsr9bj	250	9	of	of	IN
cord-301755-fxfsr9bj	250	10	deletions	deletion	NNS
cord-301755-fxfsr9bj	250	11	within	within	IN
cord-301755-fxfsr9bj	250	12	the	the	DT
cord-301755-fxfsr9bj	250	13	E2	E2	NNP
cord-301755-fxfsr9bj	250	14	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	250	15	gene	gene	NN
cord-301755-fxfsr9bj	250	16	of	of	IN
cord-301755-fxfsr9bj	250	17	several	several	JJ
cord-301755-fxfsr9bj	250	18	strains	strain	NNS
cord-301755-fxfsr9bj	250	19	of	of	IN
cord-301755-fxfsr9bj	250	20	murine	murine	JJ
cord-301755-fxfsr9bj	250	21	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	250	22	virus	virus	NN
cord-301755-fxfsr9bj	250	23	Infection	infection	NN
cord-301755-fxfsr9bj	250	24	by	by	IN
cord-301755-fxfsr9bj	250	25	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	250	26	JHM	JHM	NNP
cord-301755-fxfsr9bj	250	27	of	of	IN
cord-301755-fxfsr9bj	250	28	rat	rat	NN
cord-301755-fxfsr9bj	250	29	neurons	neuron	NNS
cord-301755-fxfsr9bj	250	30	and	and	CC
cord-301755-fxfsr9bj	250	31	oligodendrocyte	oligodendrocyte	RB
cord-301755-fxfsr9bj	250	32	-	-	HYPH
cord-301755-fxfsr9bj	250	33	type-2-astrocyte	type-2-astrocyte	NNP
cord-301755-fxfsr9bj	250	34	lineage	lineage	NN
cord-301755-fxfsr9bj	250	35	cells	cell	NNS
cord-301755-fxfsr9bj	250	36	during	during	IN
cord-301755-fxfsr9bj	250	37	distinct	distinct	JJ
cord-301755-fxfsr9bj	250	38	developmental	developmental	JJ
cord-301755-fxfsr9bj	250	39	stages	stage	NNS
cord-301755-fxfsr9bj	250	40	.	.	.
cord-301755-fxfsr9bj	251	1	I.	I.	NNP
cord-301755-fxfsr9bj	251	2	viral	viral	JJ
cord-301755-fxfsr9bj	251	3	Analysis	Analysis	NNP
cord-301755-fxfsr9bj	251	4	of	of	IN
cord-301755-fxfsr9bj	251	5	murine	murine	JJ
cord-301755-fxfsr9bj	251	6	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	251	7	surface	surface	NN
cord-301755-fxfsr9bj	251	8	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	251	9	functions	function	NNS
cord-301755-fxfsr9bj	251	10	by	by	IN
cord-301755-fxfsr9bj	251	11	using	use	VBG
cord-301755-fxfsr9bj	251	12	monoclonal	monoclonal	JJ
cord-301755-fxfsr9bj	251	13	antibodies	antibody	NNS
cord-301755-fxfsr9bj	251	14	Primer	primer	NN
cord-301755-fxfsr9bj	251	15	-	-	HYPH
cord-301755-fxfsr9bj	251	16	directed	direct	VBN
cord-301755-fxfsr9bj	251	17	enzymatic	enzymatic	JJ
cord-301755-fxfsr9bj	251	18	amplification	amplification	NN
cord-301755-fxfsr9bj	251	19	of	of	IN
cord-301755-fxfsr9bj	251	20	DNA	dna	NN
cord-301755-fxfsr9bj	251	21	with	with	IN
cord-301755-fxfsr9bj	251	22	a	a	DT
cord-301755-fxfsr9bj	251	23	thermostable	thermostable	JJ
cord-301755-fxfsr9bj	251	24	DNA	dna	NN
cord-301755-fxfsr9bj	251	25	polymerase	polymerase	NN
cord-301755-fxfsr9bj	251	26	Nucleotide	nucleotide	JJ
cord-301755-fxfsr9bj	251	27	sequence	sequence	NN
cord-301755-fxfsr9bj	251	28	of	of	IN
cord-301755-fxfsr9bj	251	29	the	the	DT
cord-301755-fxfsr9bj	251	30	gene	gene	NN
cord-301755-fxfsr9bj	251	31	encoding	encode	VBG
cord-301755-fxfsr9bj	251	32	the	the	DT
cord-301755-fxfsr9bj	251	33	surface	surface	NN
cord-301755-fxfsr9bj	251	34	projection	projection	NN
cord-301755-fxfsr9bj	251	35	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	251	36	of	of	IN
cord-301755-fxfsr9bj	251	37	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	251	38	MHV	MHV	NNP
cord-301755-fxfsr9bj	251	39	-	-	HYPH
cord-301755-fxfsr9bj	251	40	JHM	JHM	NNP
cord-301755-fxfsr9bj	251	41	Murine	Murine	NNP
cord-301755-fxfsr9bj	251	42	coronaviruses	coronaviruse	NNS
cord-301755-fxfsr9bj	251	43	:	:	:
cord-301755-fxfsr9bj	251	44	isolation	isolation	NN
cord-301755-fxfsr9bj	251	45	and	and	CC
cord-301755-fxfsr9bj	251	46	characterization	characterization	NN
cord-301755-fxfsr9bj	251	47	of	of	IN
cord-301755-fxfsr9bj	251	48	two	two	CD
cord-301755-fxfsr9bj	251	49	plaque	plaque	NN
cord-301755-fxfsr9bj	251	50	morphology	morphology	NN
cord-301755-fxfsr9bj	251	51	variants	variant	NNS
cord-301755-fxfsr9bj	251	52	of	of	IN
cord-301755-fxfsr9bj	251	53	the	the	DT
cord-301755-fxfsr9bj	251	54	JHM	JHM	NNP
cord-301755-fxfsr9bj	251	55	neurotropit	neurotropit	NNP
cord-301755-fxfsr9bj	251	56	strain	strain	NN
cord-301755-fxfsr9bj	251	57	Enhancement	Enhancement	NNP
cord-301755-fxfsr9bj	251	58	of	of	IN
cord-301755-fxfsr9bj	251	59	plaque	plaque	NN
cord-301755-fxfsr9bj	251	60	formation	formation	NN
cord-301755-fxfsr9bj	251	61	and	and	CC
cord-301755-fxfsr9bj	251	62	cell	cell	NN
cord-301755-fxfsr9bj	251	63	fusion	fusion	NN
cord-301755-fxfsr9bj	251	64	of	of	IN
cord-301755-fxfsr9bj	251	65	an	an	DT
cord-301755-fxfsr9bj	251	66	enteropathogenic	enteropathogenic	JJ
cord-301755-fxfsr9bj	251	67	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	251	68	by	by	IN
cord-301755-fxfsr9bj	251	69	trypsin	trypsin	NN
cord-301755-fxfsr9bj	251	70	treatment	treatment	NN
cord-301755-fxfsr9bj	252	1	The	the	DT
cord-301755-fxfsr9bj	252	2	molecular	molecular	JJ
cord-301755-fxfsr9bj	252	3	biology	biology	NN
cord-301755-fxfsr9bj	252	4	of	of	IN
cord-301755-fxfsr9bj	252	5	coronaviruses	coronaviruse	NNS
cord-301755-fxfsr9bj	253	1	Proteolytic	proteolytic	JJ
cord-301755-fxfsr9bj	253	2	cleavage	cleavage	NN
cord-301755-fxfsr9bj	253	3	of	of	IN
cord-301755-fxfsr9bj	253	4	the	the	DT
cord-301755-fxfsr9bj	253	5	E2	E2	NNP
cord-301755-fxfsr9bj	253	6	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	253	7	of	of	IN
cord-301755-fxfsr9bj	253	8	murine	murine	JJ
cord-301755-fxfsr9bj	253	9	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	253	10	:	:	:
cord-301755-fxfsr9bj	253	11	Activation	activation	NN
cord-301755-fxfsr9bj	253	12	of	of	IN
cord-301755-fxfsr9bj	253	13	cell	cell	NN
cord-301755-fxfsr9bj	253	14	fusing	fusing	NN
cord-301755-fxfsr9bj	253	15	activity	activity	NN
cord-301755-fxfsr9bj	253	16	of	of	IN
cord-301755-fxfsr9bj	253	17	virions	virion	NNS
cord-301755-fxfsr9bj	253	18	by	by	IN
cord-301755-fxfsr9bj	253	19	trypsin	trypsin	NN
cord-301755-fxfsr9bj	253	20	and	and	CC
cord-301755-fxfsr9bj	253	21	separation	separation	NN
cord-301755-fxfsr9bj	253	22	of	of	IN
cord-301755-fxfsr9bj	253	23	two	two	CD
cord-301755-fxfsr9bj	253	24	different	different	JJ
cord-301755-fxfsr9bj	253	25	90	90	CD
cord-301755-fxfsr9bj	253	26	K	k	NN
cord-301755-fxfsr9bj	253	27	cleavage	cleavage	NN
cord-301755-fxfsr9bj	253	28	fragments	fragment	NNS
cord-301755-fxfsr9bj	253	29	Demyelination	Demyelination	NNP
cord-301755-fxfsr9bj	253	30	induced	induce	VBN
cord-301755-fxfsr9bj	253	31	by	by	IN
cord-301755-fxfsr9bj	253	32	murine	murine	JJ
cord-301755-fxfsr9bj	253	33	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	253	34	virus	virus	NN
cord-301755-fxfsr9bj	253	35	JHM	JHM	NNP
cord-301755-fxfsr9bj	253	36	strain	strain	NN
cord-301755-fxfsr9bj	253	37	(	(	-LRB-
cord-301755-fxfsr9bj	253	38	MHV-4	MHV-4	NNP
cord-301755-fxfsr9bj	253	39	)	)	-RRB-
cord-301755-fxfsr9bj	253	40	is	be	VBZ
cord-301755-fxfsr9bj	253	41	immunologically	immunologically	RB
cord-301755-fxfsr9bj	253	42	mediated	mediate	VBN
cord-301755-fxfsr9bj	253	43	The	the	DT
cord-301755-fxfsr9bj	253	44	peplomer	peplomer	JJ
cord-301755-fxfsr9bj	253	45	protein	protein	NN
cord-301755-fxfsr9bj	253	46	E2	E2	NNP
cord-301755-fxfsr9bj	253	47	of	of	IN
cord-301755-fxfsr9bj	253	48	coronavirus	coronavirus	NN
cord-301755-fxfsr9bj	253	49	JHM	JHM	NNP
cord-301755-fxfsr9bj	253	50	as	as	IN
cord-301755-fxfsr9bj	253	51	a	a	DT
cord-301755-fxfsr9bj	253	52	determinant	determinant	NN
cord-301755-fxfsr9bj	253	53	of	of	IN
cord-301755-fxfsr9bj	253	54	neurovirulence	neurovirulence	NN
cord-301755-fxfsr9bj	253	55	:	:	:
cord-301755-fxfsr9bj	254	1	definition	definition	NN
cord-301755-fxfsr9bj	254	2	of	of	IN
cord-301755-fxfsr9bj	254	3	critical	critical	JJ
cord-301755-fxfsr9bj	254	4	epitopes	epitope	NNS
cord-301755-fxfsr9bj	254	5	by	by	IN
cord-301755-fxfsr9bj	254	6	variant	variant	NN
cord-301755-fxfsr9bj	254	7	analysis	analysis	NN
cord-301755-fxfsr9bj	254	8	Pathogenesis	Pathogenesis	NNP
cord-301755-fxfsr9bj	254	9	of	of	IN
cord-301755-fxfsr9bj	254	10	demyelination	demyelination	NN
cord-301755-fxfsr9bj	254	11	induced	induce	VBN
cord-301755-fxfsr9bj	254	12	by	by	IN
cord-301755-fxfsr9bj	254	13	a	a	DT
cord-301755-fxfsr9bj	254	14	mouse	mouse	NN
cord-301755-fxfsr9bj	254	15	hepatitis	hepatitis	NN
cord-301755-fxfsr9bj	254	16	virus	virus	NN
cord-301755-fxfsr9bj	254	17	(	(	-LRB-
cord-301755-fxfsr9bj	254	18	JHM	JHM	NNP
cord-301755-fxfsr9bj	254	19	virus	virus	NN
cord-301755-fxfsr9bj	254	20	)	)	-RRB-
cord-301755-fxfsr9bj	254	21	.	.	.
cord-301755-fxfsr9bj	255	1	Acfa	Acfa	NNP
cord-301755-fxfsr9bj	255	2	Neural	Neural	NNP
cord-301755-fxfsr9bj	255	3	Monoclonal	Monoclonal	NNP
cord-301755-fxfsr9bj	255	4	antibodies	antibody	NNS
cord-301755-fxfsr9bj	255	5	to	to	IN
cord-301755-fxfsr9bj	255	6	the	the	DT
cord-301755-fxfsr9bj	255	7	peplomer	peplomer	JJ
cord-301755-fxfsr9bj	255	8	glycoprotein	glycoprotein	NN
cord-301755-fxfsr9bj	255	9	of	of	IN
cord-301755-fxfsr9bj	255	10	coronavlrus	coronavlrus	NNP
cord-301755-fxfsr9bj	255	11	mouse	mouse	NNP
cord-301755-fxfsr9bj	255	12	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	255	13	virus	virus	NN
cord-301755-fxfsr9bj	255	14	identify	identify	VB
cord-301755-fxfsr9bj	255	15	two	two	CD
cord-301755-fxfsr9bj	255	16	subunits	subunit	NNS
cord-301755-fxfsr9bj	255	17	and	and	CC
cord-301755-fxfsr9bj	255	18	detect	detect	VB
cord-301755-fxfsr9bj	255	19	a	a	DT
cord-301755-fxfsr9bj	255	20	conformational	conformational	JJ
cord-301755-fxfsr9bj	255	21	change	change	NN
cord-301755-fxfsr9bj	255	22	in	in	IN
cord-301755-fxfsr9bj	255	23	the	the	DT
cord-301755-fxfsr9bj	255	24	subunit	subunit	NN
cord-301755-fxfsr9bj	255	25	released	release	VBN
cord-301755-fxfsr9bj	255	26	under	under	IN
cord-301755-fxfsr9bj	255	27	mild	mild	JJ
cord-301755-fxfsr9bj	255	28	alkaline	alkaline	JJ
cord-301755-fxfsr9bj	255	29	conditions	condition	NNS
cord-301755-fxfsr9bj	255	30	Heterogeneity	heterogeneity	NN
cord-301755-fxfsr9bj	255	31	of	of	IN
cord-301755-fxfsr9bj	255	32	gene	gene	NN
cord-301755-fxfsr9bj	255	33	expression	expression	NN
cord-301755-fxfsr9bj	255	34	of	of	IN
cord-301755-fxfsr9bj	255	35	the	the	DT
cord-301755-fxfsr9bj	255	36	hemagglutinin	hemagglutinin	NN
cord-301755-fxfsr9bj	255	37	-	-	HYPH
cord-301755-fxfsr9bj	255	38	esterase	esterase	NN
cord-301755-fxfsr9bj	255	39	(	(	-LRB-
cord-301755-fxfsr9bj	255	40	HE	he	NN
cord-301755-fxfsr9bj	255	41	)	)	-RRB-
cord-301755-fxfsr9bj	255	42	protein	protein	NN
cord-301755-fxfsr9bj	255	43	of	of	IN
cord-301755-fxfsr9bj	255	44	murine	murine	JJ
cord-301755-fxfsr9bj	255	45	coronaviruses	coronaviruse	NNS
cord-301755-fxfsr9bj	255	46	Role	role	NN
cord-301755-fxfsr9bj	255	47	of	of	IN
cord-301755-fxfsr9bj	255	48	protease	protease	NN
cord-301755-fxfsr9bj	255	49	in	in	IN
cord-301755-fxfsr9bj	255	50	mouse	mouse	NN
cord-301755-fxfsr9bj	255	51	hepatitis	hepatitis	NNP
cord-301755-fxfsr9bj	255	52	virus	virus	NN
cord-301755-fxfsr9bj	255	53	-	-	HYPH
cord-301755-fxfsr9bj	255	54	induced	induce	VBN
cord-301755-fxfsr9bj	255	55	cell	cell	NN
cord-301755-fxfsr9bj	255	56	fusion	fusion	NN
cord-301755-fxfsr9bj	256	1	We	-PRON-	PRP
cord-301755-fxfsr9bj	256	2	thank	thank	VBP
cord-301755-fxfsr9bj	256	3	Drs	Drs	NNP
cord-301755-fxfsr9bj	256	4	.	.	.
cord-301755-fxfsr9bj	257	1	Y	Y	NNP
cord-301755-fxfsr9bj	257	2	-	-	HYPH
cord-301755-fxfsr9bj	257	3	C.	C.	NNP
cord-301755-fxfsr9bj	257	4	Chao	Chao	NNP
cord-301755-fxfsr9bj	257	5	and	and	CC
cord-301755-fxfsr9bj	257	6	C	C	NNP
cord-301755-fxfsr9bj	257	7	-	-	HYPH
cord-301755-fxfsr9bj	257	8	Z.	Z.	NNP
cord-301755-fxfsr9bj	257	9	Lee	Lee	NNP
cord-301755-fxfsr9bj	257	10	for	for	IN
cord-301755-fxfsr9bj	257	11	technical	technical	JJ
cord-301755-fxfsr9bj	257	12	advice	advice	NN
cord-301755-fxfsr9bj	257	13	.	.	.
cord-301755-fxfsr9bj	258	1	We	-PRON-	PRP
cord-301755-fxfsr9bj	258	2	also	also	RB
cord-301755-fxfsr9bj	258	3	thank	thank	VBP
cord-301755-fxfsr9bj	258	4	Daphne	Daphne	NNP
cord-301755-fxfsr9bj	258	5	Shimoda	Shimoda	NNP
cord-301755-fxfsr9bj	258	6	for	for	IN
cord-301755-fxfsr9bj	258	7	the	the	DT
cord-301755-fxfsr9bj	258	8	manuscript	manuscript	NN
cord-301755-fxfsr9bj	258	9	preparation	preparation	NN
cord-301755-fxfsr9bj	258	10	.	.	.
cord-301755-fxfsr9bj	259	1	This	this	DT
cord-301755-fxfsr9bj	259	2	work	work	NN
cord-301755-fxfsr9bj	259	3	was	be	VBD
cord-301755-fxfsr9bj	259	4	supported	support	VBN
cord-301755-fxfsr9bj	259	5	by	by	IN
cord-301755-fxfsr9bj	259	6	U.S.	U.S.	NNP
cord-301755-fxfsr9bj	259	7	Public	Public	NNP
cord-301755-fxfsr9bj	259	8	Health	Health	NNP
cord-301755-fxfsr9bj	259	9	Services	Services	NNPS
cord-301755-fxfsr9bj	259	10	Grants	Grants	NNPS
cord-301755-fxfsr9bj	259	11	NS1816	NS1816	NNP
cord-301755-fxfsr9bj	259	12	from	from	IN
cord-301755-fxfsr9bj	259	13	the	the	DT
cord-301755-fxfsr9bj	259	14	National	National	NNP
cord-301755-fxfsr9bj	259	15	Institutes	Institutes	NNPS
cord-301755-fxfsr9bj	259	16	of	of	IN
cord-301755-fxfsr9bj	259	17	Health	Health	NNP
cord-301755-fxfsr9bj	259	18	and	and	CC
cord-301755-fxfsr9bj	259	19	RG	RG	NNP
cord-301755-fxfsr9bj	259	20	2283-A-2	2283-a-2	CD
cord-301755-fxfsr9bj	259	21	of	of	IN
cord-301755-fxfsr9bj	259	22	the	the	DT
cord-301755-fxfsr9bj	259	23	National	National	NNP
cord-301755-fxfsr9bj	259	24	Multiple	Multiple	NNP
cord-301755-fxfsr9bj	259	25	Sclerosis	Sclerosis	NNP
cord-301755-fxfsr9bj	259	26	Society	Society	NNP
cord-301755-fxfsr9bj	259	27	.	.	.
cord-301755-fxfsr9bj	260	1	F.I.W.	F.I.W.	NNP
cord-301755-fxfsr9bj	260	2	is	be	VBZ
cord-301755-fxfsr9bj	260	3	a	a	DT
cord-301755-fxfsr9bj	260	4	recipient	recipient	NN
cord-301755-fxfsr9bj	260	5	of	of	IN
cord-301755-fxfsr9bj	260	6	postdoctoral	postdoctoral	JJ
cord-301755-fxfsr9bj	260	7	training	training	NN
cord-301755-fxfsr9bj	260	8	fellowship	fellowship	NN
cord-301755-fxfsr9bj	260	9	from	from	IN
cord-301755-fxfsr9bj	260	10	NIH	NIH	NNP
cord-301755-fxfsr9bj	260	11	.	.	.
cord-301755-fxfsr9bj	261	1	M.M.C.L.	M.M.C.L.	NNP
cord-301755-fxfsr9bj	261	2	is	be	VBZ
cord-301755-fxfsr9bj	261	3	an	an	DT
cord-301755-fxfsr9bj	261	4	Investigator	Investigator	NNP
cord-301755-fxfsr9bj	261	5	of	of	IN
cord-301755-fxfsr9bj	261	6	Howard	Howard	NNP
cord-301755-fxfsr9bj	261	7	Hughes	Hughes	NNP
cord-301755-fxfsr9bj	261	8	Medical	Medical	NNP
cord-301755-fxfsr9bj	261	9	Institute	Institute	NNP
cord-301755-fxfsr9bj	261	10	.	.	.