id	sid	tid	token	lemma	pos
cord-310748-ao29zx1u	1	1	key	key	JJ
cord-310748-ao29zx1u	2	1	:	:	:
cord-310748-ao29zx1u	2	2	cord-310748-ao29zx1u	cord-310748-ao29zx1u	CD
cord-310748-ao29zx1u	2	3	authors	author	NNS
cord-310748-ao29zx1u	2	4	:	:	:
cord-310748-ao29zx1u	3	1	Banner	Banner	NNP
cord-310748-ao29zx1u	3	2	,	,	,
cord-310748-ao29zx1u	3	3	Lisa	Lisa	NNP
cord-310748-ao29zx1u	3	4	R.	R.	NNP
cord-310748-ao29zx1u	3	5	;	;	:
cord-310748-ao29zx1u	3	6	Mc	Mc	NNP
cord-310748-ao29zx1u	3	7	Lai	Lai	NNP
cord-310748-ao29zx1u	3	8	,	,	,
cord-310748-ao29zx1u	4	1	Michael	Michael	NNP
cord-310748-ao29zx1u	4	2	title	title	NN
cord-310748-ao29zx1u	4	3	:	:	:
cord-310748-ao29zx1u	5	1	Random	random	JJ
cord-310748-ao29zx1u	5	2	nature	nature	NN
cord-310748-ao29zx1u	5	3	of	of	IN
cord-310748-ao29zx1u	5	4	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	5	5	RNA	RNA	NNP
cord-310748-ao29zx1u	5	6	recombination	recombination	NN
cord-310748-ao29zx1u	5	7	in	in	IN
cord-310748-ao29zx1u	5	8	the	the	DT
cord-310748-ao29zx1u	5	9	absence	absence	NN
cord-310748-ao29zx1u	5	10	of	of	IN
cord-310748-ao29zx1u	5	11	selection	selection	NN
cord-310748-ao29zx1u	5	12	pressure	pressure	NN
cord-310748-ao29zx1u	5	13	date	date	NN
cord-310748-ao29zx1u	5	14	:	:	:
cord-310748-ao29zx1u	5	15	1991	1991	CD
cord-310748-ao29zx1u	5	16	-	-	SYM
cord-310748-ao29zx1u	5	17	11	11	CD
cord-310748-ao29zx1u	5	18	-	-	SYM
cord-310748-ao29zx1u	5	19	30	30	CD
cord-310748-ao29zx1u	5	20	journal	journal	NN
cord-310748-ao29zx1u	5	21	:	:	:
cord-310748-ao29zx1u	6	1	Virology	virology	NN
cord-310748-ao29zx1u	6	2	DOI	DOI	NNP
cord-310748-ao29zx1u	6	3	:	:	:
cord-310748-ao29zx1u	6	4	10.1016/0042	10.1016/0042	CD
cord-310748-ao29zx1u	6	5	-	-	SYM
cord-310748-ao29zx1u	6	6	6822(91)90795-d	6822(91)90795-d	CD
cord-310748-ao29zx1u	6	7	sha	sha	NN
cord-310748-ao29zx1u	6	8	:	:	:
cord-310748-ao29zx1u	6	9	4ae77ea67b2f20f2e875c8ac9bde01d13bf2b992	4ae77ea67b2f20f2e875c8ac9bde01d13bf2b992	CD
cord-310748-ao29zx1u	6	10	doc_id	doc_id	CD
cord-310748-ao29zx1u	6	11	:	:	:
cord-310748-ao29zx1u	6	12	310748	310748	CD
cord-310748-ao29zx1u	6	13	cord_uid	cord_uid	NN
cord-310748-ao29zx1u	6	14	:	:	:
cord-310748-ao29zx1u	7	1	ao29zx1u	ao29zx1u	NNP
cord-310748-ao29zx1u	7	2	Abstract	Abstract	NNP
cord-310748-ao29zx1u	7	3	RNA	RNA	NNP
cord-310748-ao29zx1u	7	4	-	-	HYPH
cord-310748-ao29zx1u	7	5	RNA	RNA	NNP
cord-310748-ao29zx1u	7	6	recombination	recombination	NN
cord-310748-ao29zx1u	7	7	is	be	VBZ
cord-310748-ao29zx1u	7	8	thought	think	VBN
cord-310748-ao29zx1u	7	9	to	to	TO
cord-310748-ao29zx1u	7	10	occur	occur	VB
cord-310748-ao29zx1u	7	11	preferentially	preferentially	RB
cord-310748-ao29zx1u	7	12	at	at	IN
cord-310748-ao29zx1u	7	13	certain	certain	JJ
cord-310748-ao29zx1u	7	14	selected	select	VBN
cord-310748-ao29zx1u	7	15	sites	site	NNS
cord-310748-ao29zx1u	7	16	and	and	CC
cord-310748-ao29zx1u	7	17	in	in	IN
cord-310748-ao29zx1u	7	18	only	only	RB
cord-310748-ao29zx1u	7	19	a	a	DT
cord-310748-ao29zx1u	7	20	few	few	JJ
cord-310748-ao29zx1u	7	21	RNA	RNA	NNP
cord-310748-ao29zx1u	7	22	viruses	virus	NNS
cord-310748-ao29zx1u	7	23	;	;	:
cord-310748-ao29zx1u	7	24	the	the	DT
cord-310748-ao29zx1u	7	25	mechanism	mechanism	NN
cord-310748-ao29zx1u	7	26	for	for	IN
cord-310748-ao29zx1u	7	27	these	these	DT
cord-310748-ao29zx1u	7	28	restrictions	restriction	NNS
cord-310748-ao29zx1u	7	29	is	be	VBZ
cord-310748-ao29zx1u	7	30	unknown	unknown	JJ
cord-310748-ao29zx1u	7	31	.	.	.
cord-310748-ao29zx1u	8	1	In	in	IN
cord-310748-ao29zx1u	8	2	this	this	DT
cord-310748-ao29zx1u	8	3	paper	paper	NN
cord-310748-ao29zx1u	8	4	we	-PRON-	PRP
cord-310748-ao29zx1u	8	5	report	report	VBP
cord-310748-ao29zx1u	8	6	the	the	DT
cord-310748-ao29zx1u	8	7	development	development	NN
cord-310748-ao29zx1u	8	8	of	of	IN
cord-310748-ao29zx1u	8	9	a	a	DT
cord-310748-ao29zx1u	8	10	recombination	recombination	NN
cord-310748-ao29zx1u	8	11	assay	assay	NN
cord-310748-ao29zx1u	8	12	for	for	IN
cord-310748-ao29zx1u	8	13	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	8	14	,	,	,
cord-310748-ao29zx1u	8	15	using	use	VBG
cord-310748-ao29zx1u	8	16	polymerase	polymerase	NN
cord-310748-ao29zx1u	8	17	chain	chain	NN
cord-310748-ao29zx1u	8	18	reaction	reaction	NN
cord-310748-ao29zx1u	8	19	,	,	,
cord-310748-ao29zx1u	8	20	in	in	IN
cord-310748-ao29zx1u	8	21	the	the	DT
cord-310748-ao29zx1u	8	22	absence	absence	NN
cord-310748-ao29zx1u	8	23	of	of	IN
cord-310748-ao29zx1u	8	24	selection	selection	NN
cord-310748-ao29zx1u	8	25	pressure	pressure	NN
cord-310748-ao29zx1u	8	26	.	.	.
cord-310748-ao29zx1u	9	1	Our	-PRON-	PRP$
cord-310748-ao29zx1u	9	2	results	result	NNS
cord-310748-ao29zx1u	9	3	showed	show	VBD
cord-310748-ao29zx1u	9	4	that	that	IN
cord-310748-ao29zx1u	9	5	within	within	IN
cord-310748-ao29zx1u	9	6	a	a	DT
cord-310748-ao29zx1u	9	7	1-kb	1-kb	CD
cord-310748-ao29zx1u	9	8	region	region	NN
cord-310748-ao29zx1u	9	9	of	of	IN
cord-310748-ao29zx1u	9	10	the	the	DT
cord-310748-ao29zx1u	9	11	peplomer	peplomer	NNP
cord-310748-ao29zx1u	9	12	gene	gene	NN
cord-310748-ao29zx1u	9	13	,	,	,
cord-310748-ao29zx1u	9	14	RNA	RNA	NNP
cord-310748-ao29zx1u	9	15	recombination	recombination	NN
cord-310748-ao29zx1u	9	16	occurred	occur	VBD
cord-310748-ao29zx1u	9	17	at	at	IN
cord-310748-ao29zx1u	9	18	almost	almost	RB
cord-310748-ao29zx1u	9	19	every	every	DT
cord-310748-ao29zx1u	9	20	potential	potential	JJ
cord-310748-ao29zx1u	9	21	crossover	crossover	NN
cord-310748-ao29zx1u	9	22	site	site	NN
cord-310748-ao29zx1u	9	23	.	.	.
cord-310748-ao29zx1u	10	1	Thus	thus	RB
cord-310748-ao29zx1u	10	2	,	,	,
cord-310748-ao29zx1u	10	3	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	10	4	RNA	RNA	NNP
cord-310748-ao29zx1u	10	5	recombination	recombination	NN
cord-310748-ao29zx1u	10	6	appears	appear	VBZ
cord-310748-ao29zx1u	10	7	to	to	TO
cord-310748-ao29zx1u	10	8	be	be	VB
cord-310748-ao29zx1u	10	9	more	more	RBR
cord-310748-ao29zx1u	10	10	random	random	JJ
cord-310748-ao29zx1u	10	11	than	than	IN
cord-310748-ao29zx1u	10	12	previously	previously	RB
cord-310748-ao29zx1u	10	13	realized	realize	VBN
cord-310748-ao29zx1u	10	14	.	.	.
cord-310748-ao29zx1u	11	1	However	however	RB
cord-310748-ao29zx1u	11	2	,	,	,
cord-310748-ao29zx1u	11	3	after	after	IN
cord-310748-ao29zx1u	11	4	serial	serial	JJ
cord-310748-ao29zx1u	11	5	passages	passage	NNS
cord-310748-ao29zx1u	11	6	of	of	IN
cord-310748-ao29zx1u	11	7	the	the	DT
cord-310748-ao29zx1u	11	8	recombinant	recombinant	JJ
cord-310748-ao29zx1u	11	9	viruses	virus	NNS
cord-310748-ao29zx1u	11	10	in	in	IN
cord-310748-ao29zx1u	11	11	tissue	tissue	NN
cord-310748-ao29zx1u	11	12	culture	culture	NN
cord-310748-ao29zx1u	11	13	,	,	,
cord-310748-ao29zx1u	11	14	the	the	DT
cord-310748-ao29zx1u	11	15	recombination	recombination	NN
cord-310748-ao29zx1u	11	16	sites	site	NNS
cord-310748-ao29zx1u	11	17	among	among	IN
cord-310748-ao29zx1u	11	18	the	the	DT
cord-310748-ao29zx1u	11	19	progeny	progeny	NN
cord-310748-ao29zx1u	11	20	viruses	virus	NNS
cord-310748-ao29zx1u	11	21	became	become	VBD
cord-310748-ao29zx1u	11	22	clustered	cluster	VBN
cord-310748-ao29zx1u	11	23	in	in	IN
cord-310748-ao29zx1u	11	24	the	the	DT
cord-310748-ao29zx1u	11	25	region	region	NN
cord-310748-ao29zx1u	11	26	which	which	WDT
cord-310748-ao29zx1u	11	27	contains	contain	VBZ
cord-310748-ao29zx1u	11	28	the	the	DT
cord-310748-ao29zx1u	11	29	previously	previously	RB
cord-310748-ao29zx1u	11	30	reported	report	VBN
cord-310748-ao29zx1u	11	31	“	"	``
cord-310748-ao29zx1u	11	32	hot	hot	JJ
cord-310748-ao29zx1u	11	33	spot	spot	NN
cord-310748-ao29zx1u	11	34	”	"	''
cord-310748-ao29zx1u	11	35	for	for	IN
cord-310748-ao29zx1u	11	36	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	11	37	recombination	recombination	NN
cord-310748-ao29zx1u	11	38	.	.	.
cord-310748-ao29zx1u	12	1	These	these	DT
cord-310748-ao29zx1u	12	2	results	result	NNS
cord-310748-ao29zx1u	12	3	suggest	suggest	VBP
cord-310748-ao29zx1u	12	4	that	that	IN
cord-310748-ao29zx1u	12	5	RNA	RNA	NNP
cord-310748-ao29zx1u	12	6	recombination	recombination	NN
cord-310748-ao29zx1u	12	7	is	be	VBZ
cord-310748-ao29zx1u	12	8	common	common	JJ
cord-310748-ao29zx1u	12	9	and	and	CC
cord-310748-ao29zx1u	12	10	random	random	JJ
cord-310748-ao29zx1u	12	11	in	in	IN
cord-310748-ao29zx1u	12	12	nature	nature	NN
cord-310748-ao29zx1u	12	13	,	,	,
cord-310748-ao29zx1u	12	14	but	but	CC
cord-310748-ao29zx1u	12	15	only	only	RB
cord-310748-ao29zx1u	12	16	certain	certain	JJ
cord-310748-ao29zx1u	12	17	recombinants	recombinant	NNS
cord-310748-ao29zx1u	12	18	can	can	MD
cord-310748-ao29zx1u	12	19	be	be	VB
cord-310748-ao29zx1u	12	20	selected	select	VBN
cord-310748-ao29zx1u	12	21	.	.	.
cord-310748-ao29zx1u	13	1	Thus	thus	RB
cord-310748-ao29zx1u	13	2	,	,	,
cord-310748-ao29zx1u	13	3	the	the	DT
cord-310748-ao29zx1u	13	4	presence	presence	NN
cord-310748-ao29zx1u	13	5	of	of	IN
cord-310748-ao29zx1u	13	6	recombinational	recombinational	JJ
cord-310748-ao29zx1u	13	7	“	"	``
cord-310748-ao29zx1u	13	8	hot	hot	JJ
cord-310748-ao29zx1u	13	9	spots	spot	NNS
cord-310748-ao29zx1u	13	10	”	"	''
cord-310748-ao29zx1u	13	11	for	for	IN
cord-310748-ao29zx1u	13	12	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	13	13	or	or	CC
cord-310748-ao29zx1u	13	14	other	other	JJ
cord-310748-ao29zx1u	13	15	RNA	RNA	NNP
cord-310748-ao29zx1u	13	16	viruses	virus	NNS
cord-310748-ao29zx1u	13	17	most	most	RBS
cord-310748-ao29zx1u	13	18	likely	likely	RB
cord-310748-ao29zx1u	13	19	resulted	result	VBD
cord-310748-ao29zx1u	13	20	from	from	IN
cord-310748-ao29zx1u	13	21	selection	selection	NN
cord-310748-ao29zx1u	13	22	of	of	IN
cord-310748-ao29zx1u	13	23	certain	certain	JJ
cord-310748-ao29zx1u	13	24	recombinant	recombinant	JJ
cord-310748-ao29zx1u	13	25	viruses	virus	NNS
cord-310748-ao29zx1u	13	26	and	and	CC
cord-310748-ao29zx1u	13	27	not	not	RB
cord-310748-ao29zx1u	13	28	restriction	restriction	NN
cord-310748-ao29zx1u	13	29	on	on	IN
cord-310748-ao29zx1u	13	30	the	the	DT
cord-310748-ao29zx1u	13	31	occurrence	occurrence	NN
cord-310748-ao29zx1u	13	32	of	of	IN
cord-310748-ao29zx1u	13	33	RNA	RNA	NNP
cord-310748-ao29zx1u	13	34	recombination	recombination	NN
cord-310748-ao29zx1u	13	35	.	.	.
cord-310748-ao29zx1u	14	1	The	the	DT
cord-310748-ao29zx1u	14	2	failure	failure	NN
cord-310748-ao29zx1u	14	3	to	to	TO
cord-310748-ao29zx1u	14	4	detect	detect	VB
cord-310748-ao29zx1u	14	5	recombinants	recombinant	NNS
cord-310748-ao29zx1u	14	6	in	in	IN
cord-310748-ao29zx1u	14	7	other	other	JJ
cord-310748-ao29zx1u	14	8	RNA	RNA	NNP
cord-310748-ao29zx1u	14	9	viruses	virus	NNS
cord-310748-ao29zx1u	14	10	may	may	MD
cord-310748-ao29zx1u	14	11	therefore	therefore	RB
cord-310748-ao29zx1u	14	12	be	be	VB
cord-310748-ao29zx1u	14	13	due	due	JJ
cord-310748-ao29zx1u	14	14	to	to	IN
cord-310748-ao29zx1u	14	15	unfavorable	unfavorable	JJ
cord-310748-ao29zx1u	14	16	properties	property	NNS
cord-310748-ao29zx1u	14	17	of	of	IN
cord-310748-ao29zx1u	14	18	recombinant	recombinant	JJ
cord-310748-ao29zx1u	14	19	viruses	virus	NNS
cord-310748-ao29zx1u	14	20	.	.	.
cord-310748-ao29zx1u	15	1	This	this	DT
cord-310748-ao29zx1u	15	2	approach	approach	NN
cord-310748-ao29zx1u	15	3	can	can	MD
cord-310748-ao29zx1u	15	4	be	be	VB
cord-310748-ao29zx1u	15	5	used	use	VBN
cord-310748-ao29zx1u	15	6	to	to	TO
cord-310748-ao29zx1u	15	7	detect	detect	VB
cord-310748-ao29zx1u	15	8	recombinants	recombinant	NNS
cord-310748-ao29zx1u	15	9	in	in	IN
cord-310748-ao29zx1u	15	10	these	these	DT
cord-310748-ao29zx1u	15	11	viruses	virus	NNS
cord-310748-ao29zx1u	15	12	.	.	.
cord-310748-ao29zx1u	16	1	The	the	DT
cord-310748-ao29zx1u	16	2	ability	ability	NN
cord-310748-ao29zx1u	16	3	to	to	TO
cord-310748-ao29zx1u	16	4	exchange	exchange	VB
cord-310748-ao29zx1u	16	5	genetic	genetic	JJ
cord-310748-ao29zx1u	16	6	information	information	NN
cord-310748-ao29zx1u	16	7	may	may	MD
cord-310748-ao29zx1u	16	8	allow	allow	VB
cord-310748-ao29zx1u	16	9	RNA	RNA	NNP
cord-310748-ao29zx1u	16	10	viruses	virus	NNS
cord-310748-ao29zx1u	16	11	to	to	TO
cord-310748-ao29zx1u	16	12	adapt	adapt	VB
cord-310748-ao29zx1u	16	13	to	to	IN
cord-310748-ao29zx1u	16	14	a	a	DT
cord-310748-ao29zx1u	16	15	changing	change	VBG
cord-310748-ao29zx1u	16	16	environment	environment	NN
cord-310748-ao29zx1u	16	17	and	and	CC
cord-310748-ao29zx1u	16	18	to	to	TO
cord-310748-ao29zx1u	16	19	overcome	overcome	VB
cord-310748-ao29zx1u	16	20	potential	potential	JJ
cord-310748-ao29zx1u	16	21	deleterious	deleterious	JJ
cord-310748-ao29zx1u	16	22	effects	effect	NNS
cord-310748-ao29zx1u	16	23	caused	cause	VBN
cord-310748-ao29zx1u	16	24	by	by	IN
cord-310748-ao29zx1u	16	25	the	the	DT
cord-310748-ao29zx1u	16	26	high	high	JJ
cord-310748-ao29zx1u	16	27	error	error	NN
cord-310748-ao29zx1u	16	28	frequency	frequency	NN
cord-310748-ao29zx1u	16	29	of	of	IN
cord-310748-ao29zx1u	16	30	the	the	DT
cord-310748-ao29zx1u	16	31	RNA	RNA	NNP
cord-310748-ao29zx1u	16	32	polymerase	polymerase	NN
cord-310748-ao29zx1u	16	33	.	.	.
cord-310748-ao29zx1u	17	1	Viruses	virus	NNS
cord-310748-ao29zx1u	17	2	with	with	IN
cord-310748-ao29zx1u	17	3	segmented	segmented	JJ
cord-310748-ao29zx1u	17	4	genomes	genome	NNS
cord-310748-ao29zx1u	17	5	can	can	MD
cord-310748-ao29zx1u	17	6	undergo	undergo	VB
cord-310748-ao29zx1u	17	7	RNA	RNA	NNP
cord-310748-ao29zx1u	17	8	reassortment	reassortment	NN
cord-310748-ao29zx1u	17	9	.	.	.
cord-310748-ao29zx1u	18	1	However	however	RB
cord-310748-ao29zx1u	18	2	,	,	,
cord-310748-ao29zx1u	18	3	the	the	DT
cord-310748-ao29zx1u	18	4	ability	ability	NN
cord-310748-ao29zx1u	18	5	of	of	IN
cord-310748-ao29zx1u	18	6	RNA	RNA	NNP
cord-310748-ao29zx1u	18	7	viruses	virus	NNS
cord-310748-ao29zx1u	18	8	with	with	IN
cord-310748-ao29zx1u	18	9	nonsegmented	nonsegmente	VBN
cord-310748-ao29zx1u	18	10	genomes	genome	NNS
cord-310748-ao29zx1u	18	11	to	to	TO
cord-310748-ao29zx1u	18	12	exchange	exchange	VB
cord-310748-ao29zx1u	18	13	genetic	genetic	JJ
cord-310748-ao29zx1u	18	14	elements	element	NNS
cord-310748-ao29zx1u	18	15	is	be	VBZ
cord-310748-ao29zx1u	18	16	more	more	RBR
cord-310748-ao29zx1u	18	17	limited	limited	JJ
cord-310748-ao29zx1u	18	18	.	.	.
cord-310748-ao29zx1u	19	1	Only	only	RB
cord-310748-ao29zx1u	19	2	a	a	DT
cord-310748-ao29zx1u	19	3	few	few	JJ
cord-310748-ao29zx1u	19	4	RNA	RNA	NNP
cord-310748-ao29zx1u	19	5	viruses	virus	NNS
cord-310748-ao29zx1u	19	6	,	,	,
cord-310748-ao29zx1u	19	7	including	include	VBG
cord-310748-ao29zx1u	19	8	picornaviruses	picornavirus	NNS
cord-310748-ao29zx1u	19	9	,	,	,
cord-310748-ao29zx1u	19	10	coronaviruses	coronaviruse	NNS
cord-310748-ao29zx1u	19	11	,	,	,
cord-310748-ao29zx1u	19	12	and	and	CC
cord-310748-ao29zx1u	19	13	a	a	DT
cord-310748-ao29zx1u	19	14	few	few	JJ
cord-310748-ao29zx1u	19	15	plant	plant	NN
cord-310748-ao29zx1u	19	16	viruses	virus	NNS
cord-310748-ao29zx1u	19	17	have	have	VBP
cord-310748-ao29zx1u	19	18	been	be	VBN
cord-310748-ao29zx1u	19	19	shown	show	VBN
cord-310748-ao29zx1u	19	20	to	to	TO
cord-310748-ao29zx1u	19	21	undergo	undergo	VB
cord-310748-ao29zx1u	19	22	RNA	RNA	NNP
cord-310748-ao29zx1u	19	23	-	-	HYPH
cord-310748-ao29zx1u	19	24	RNA	RNA	NNP
cord-310748-ao29zx1u	19	25	recombination	recombination	NN
cord-310748-ao29zx1u	19	26	at	at	IN
cord-310748-ao29zx1u	19	27	various	various	JJ
cord-310748-ao29zx1u	19	28	efficiencies	efficiency	NNS
cord-310748-ao29zx1u	19	29	(	(	-LRB-
cord-310748-ao29zx1u	19	30	I-7	I-7	NNP
cord-310748-ao29zx1u	19	31	)	)	-RRB-
cord-310748-ao29zx1u	19	32	.	.	.
cord-310748-ao29zx1u	20	1	The	the	DT
cord-310748-ao29zx1u	20	2	failure	failure	NN
cord-310748-ao29zx1u	20	3	of	of	IN
cord-310748-ao29zx1u	20	4	many	many	JJ
cord-310748-ao29zx1u	20	5	other	other	JJ
cord-310748-ao29zx1u	20	6	RNA	RNA	NNP
cord-310748-ao29zx1u	20	7	viruses	virus	NNS
cord-310748-ao29zx1u	20	8	and	and	CC
cord-310748-ao29zx1u	20	9	RNA	RNA	NNP
cord-310748-ao29zx1u	20	10	phages	phage	NNS
cord-310748-ao29zx1u	20	11	to	to	TO
cord-310748-ao29zx1u	20	12	recombine	recombine	VB
cord-310748-ao29zx1u	20	13	has	have	VBZ
cord-310748-ao29zx1u	20	14	been	be	VBN
cord-310748-ao29zx1u	20	15	well	well	RB
cord-310748-ao29zx1u	20	16	documented	document	VBN
cord-310748-ao29zx1u	20	17	(	(	-LRB-
cord-310748-ao29zx1u	20	18	8	8	CD
cord-310748-ao29zx1u	20	19	,	,	,
cord-310748-ao29zx1u	20	20	9	9	CD
cord-310748-ao29zx1u	20	21	)	)	-RRB-
cord-310748-ao29zx1u	20	22	although	although	IN
cord-310748-ao29zx1u	20	23	recent	recent	JJ
cord-310748-ao29zx1u	20	24	studies	study	NNS
cord-310748-ao29zx1u	20	25	have	have	VBP
cord-310748-ao29zx1u	20	26	identified	identify	VBN
cord-310748-ao29zx1u	20	27	additional	additional	JJ
cord-310748-ao29zx1u	20	28	viruses	virus	NNS
cord-310748-ao29zx1u	20	29	which	which	WDT
cord-310748-ao29zx1u	20	30	undergo	undergo	VBP
cord-310748-ao29zx1u	20	31	nonhomologous	nonhomologous	NNP
cord-310748-ao29zx1u	20	32	RNA	RNA	NNP
cord-310748-ao29zx1u	20	33	recombination	recombination	NN
cord-310748-ao29zx1u	20	34	under	under	IN
cord-310748-ao29zx1u	20	35	special	special	JJ
cord-310748-ao29zx1u	20	36	circumstances	circumstance	NNS
cord-310748-ao29zx1u	20	37	(	(	-LRB-
cord-310748-ao29zx1u	20	38	70	70	CD
cord-310748-ao29zx1u	20	39	,	,	,
cord-310748-ao29zx1u	20	40	1	1	CD
cord-310748-ao29zx1u	20	41	I	i	NN
cord-310748-ao29zx1u	20	42	)	)	-RRB-
cord-310748-ao29zx1u	20	43	.	.	.
cord-310748-ao29zx1u	21	1	Nevertheless	nevertheless	RB
cord-310748-ao29zx1u	21	2	,	,	,
cord-310748-ao29zx1u	21	3	homologous	homologous	JJ
cord-310748-ao29zx1u	21	4	RNA	RNA	NNP
cord-310748-ao29zx1u	21	5	recombination	recombination	NN
cord-310748-ao29zx1u	21	6	remains	remain	VBZ
cord-310748-ao29zx1u	21	7	rare	rare	JJ
cord-310748-ao29zx1u	21	8	despite	despite	IN
cord-310748-ao29zx1u	21	9	the	the	DT
cord-310748-ao29zx1u	21	10	fact	fact	NN
cord-310748-ao29zx1u	21	11	that	that	IN
cord-310748-ao29zx1u	21	12	nonhomologous	nonhomologous	NNP
cord-310748-ao29zx1u	21	13	RNA	RNA	NNP
cord-310748-ao29zx1u	21	14	rearrangement	rearrangement	NN
cord-310748-ao29zx1u	21	15	,	,	,
cord-310748-ao29zx1u	21	16	in	in	IN
cord-310748-ao29zx1u	21	17	the	the	DT
cord-310748-ao29zx1u	21	18	form	form	NN
cord-310748-ao29zx1u	21	19	of	of	IN
cord-310748-ao29zx1u	21	20	defective	defective	JJ
cord-310748-ao29zx1u	21	21	-	-	HYPH
cord-310748-ao29zx1u	21	22	interfering	interfere	VBG
cord-310748-ao29zx1u	21	23	(	(	-LRB-
cord-310748-ao29zx1u	21	24	DI	DI	NNP
cord-310748-ao29zx1u	21	25	)	)	-RRB-
cord-310748-ao29zx1u	21	26	RNA	RNA	NNP
cord-310748-ao29zx1u	21	27	,	,	,
cord-310748-ao29zx1u	21	28	has	have	VBZ
cord-310748-ao29zx1u	21	29	been	be	VBN
cord-310748-ao29zx1u	21	30	widely	widely	RB
cord-310748-ao29zx1u	21	31	demonstrated	demonstrate	VBN
cord-310748-ao29zx1u	21	32	for	for	IN
cord-310748-ao29zx1u	21	33	most	most	JJS
cord-310748-ao29zx1u	21	34	RNA	RNA	NNP
cord-310748-ao29zx1u	21	35	viruses	virus	NNS
cord-310748-ao29zx1u	21	36	.	.	.
cord-310748-ao29zx1u	22	1	The	the	DT
cord-310748-ao29zx1u	22	2	attempted	attempt	VBN
cord-310748-ao29zx1u	22	3	isolation	isolation	NN
cord-310748-ao29zx1u	22	4	of	of	IN
cord-310748-ao29zx1u	22	5	recombinants	recombinant	NNS
cord-310748-ao29zx1u	22	6	in	in	IN
cord-310748-ao29zx1u	22	7	RNA	RNA	NNP
cord-310748-ao29zx1u	22	8	viruses	virus	NNS
cord-310748-ao29zx1u	22	9	has	have	VBZ
cord-310748-ao29zx1u	22	10	usually	usually	RB
cord-310748-ao29zx1u	22	11	been	be	VBN
cord-310748-ao29zx1u	22	12	carried	carry	VBN
cord-310748-ao29zx1u	22	13	out	out	RP
cord-310748-ao29zx1u	22	14	by	by	IN
cord-310748-ao29zx1u	22	15	applying	apply	VBG
cord-310748-ao29zx1u	22	16	certain	certain	JJ
cord-310748-ao29zx1u	22	17	selection	selection	NN
cord-310748-ao29zx1u	22	18	pressures	pressure	NNS
cord-310748-ao29zx1u	22	19	and	and	CC
cord-310748-ao29zx1u	22	20	assaying	assay	VBG
cord-310748-ao29zx1u	22	21	the	the	DT
cord-310748-ao29zx1u	22	22	progeny	progeny	JJ
cord-310748-ao29zx1u	22	23	virus	virus	NN
cord-310748-ao29zx1u	22	24	harvested	harvest	VBN
cord-310748-ao29zx1u	22	25	.	.	.
cord-310748-ao29zx1u	23	1	This	this	DT
cord-310748-ao29zx1u	23	2	approach	approach	NN
cord-310748-ao29zx1u	23	3	most	most	RBS
cord-310748-ao29zx1u	23	4	likely	likely	RB
cord-310748-ao29zx1u	23	5	detects	detect	VBZ
cord-310748-ao29zx1u	23	6	only	only	RB
cord-310748-ao29zx1u	23	7	those	those	DT
cord-310748-ao29zx1u	23	8	recombinant	recombinant	JJ
cord-310748-ao29zx1u	23	9	viruses	virus	NNS
cord-310748-ao29zx1u	23	10	which	which	WDT
cord-310748-ao29zx1u	23	11	do	do	VBP
cord-310748-ao29zx1u	23	12	not	not	RB
cord-310748-ao29zx1u	23	13	lose	lose	VB
cord-310748-ao29zx1u	23	14	their	-PRON-	PRP$
cord-310748-ao29zx1u	23	15	survival	survival	NN
cord-310748-ao29zx1u	23	16	fitness	fitness	NN
cord-310748-ao29zx1u	23	17	under	under	IN
cord-310748-ao29zx1u	23	18	the	the	DT
cord-310748-ao29zx1u	23	19	selection	selection	NN
cord-310748-ao29zx1u	23	20	pressures	pressure	NNS
cord-310748-ao29zx1u	23	21	.	.	.
cord-310748-ao29zx1u	24	1	By	by	IN
cord-310748-ao29zx1u	24	2	this	this	DT
cord-310748-ao29zx1u	24	3	approach	approach	NN
cord-310748-ao29zx1u	24	4	,	,	,
cord-310748-ao29zx1u	24	5	it	-PRON-	PRP
cord-310748-ao29zx1u	24	6	has	have	VBZ
cord-310748-ao29zx1u	24	7	been	be	VBN
cord-310748-ao29zx1u	24	8	shown	show	VBN
cord-310748-ao29zx1u	24	9	that	that	IN
cord-310748-ao29zx1u	24	10	foot	foot	NN
cord-310748-ao29zx1u	24	11	-	-	HYPH
cord-310748-ao29zx1u	24	12	and	and	CC
cord-310748-ao29zx1u	24	13	-	-	HYPH
cord-310748-ao29zx1u	24	14	mouth	mouth	NN
cord-310748-ao29zx1u	24	15	disease	disease	NN
cord-310748-ao29zx1u	24	16	virus	virus	NN
cord-310748-ao29zx1u	24	17	(	(	-LRB-
cord-310748-ao29zx1u	24	18	FMDV	FMDV	NNP
cord-310748-ao29zx1u	24	19	)	)	-RRB-
cord-310748-ao29zx1u	24	20	recombines	recombine	VBZ
cord-310748-ao29zx1u	24	21	in	in	IN
cord-310748-ao29zx1u	24	22	most	most	JJS
cord-310748-ao29zx1u	24	23	genetic	genetic	JJ
cord-310748-ao29zx1u	24	24	regions	region	NNS
cord-310748-ao29zx1u	24	25	'	'	''
cord-310748-ao29zx1u	24	26	To	to	IN
cord-310748-ao29zx1u	24	27	whom	whom	WP
cord-310748-ao29zx1u	24	28	requests	request	VBZ
cord-310748-ao29zx1u	24	29	for	for	IN
cord-310748-ao29zx1u	24	30	reprints	reprint	NNS
cord-310748-ao29zx1u	24	31	should	should	MD
cord-310748-ao29zx1u	24	32	be	be	VB
cord-310748-ao29zx1u	24	33	addressed	address	VBN
cord-310748-ao29zx1u	24	34	except	except	IN
cord-310748-ao29zx1u	24	35	the	the	DT
cord-310748-ao29zx1u	24	36	viral	viral	JJ
cord-310748-ao29zx1u	24	37	capsid	capsid	NN
cord-310748-ao29zx1u	24	38	protein	protein	NN
cord-310748-ao29zx1u	24	39	VP1	VP1	NNP
cord-310748-ao29zx1u	24	40	and	and	CC
cord-310748-ao29zx1u	24	41	VP3	VP3	NNP
cord-310748-ao29zx1u	24	42	genes	gene	NNS
cord-310748-ao29zx1u	24	43	(	(	-LRB-
cord-310748-ao29zx1u	24	44	1	1	CD
cord-310748-ao29zx1u	24	45	)	)	-RRB-
cord-310748-ao29zx1u	24	46	.	.	.
cord-310748-ao29zx1u	25	1	Similarly	similarly	RB
cord-310748-ao29zx1u	25	2	,	,	,
cord-310748-ao29zx1u	25	3	mouse	mouse	NNP
cord-310748-ao29zx1u	25	4	hepatitis	hepatitis	NN
cord-310748-ao29zx1u	25	5	virus	virus	NN
cord-310748-ao29zx1u	25	6	(	(	-LRB-
cord-310748-ao29zx1u	25	7	MHV	MHV	NNP
cord-310748-ao29zx1u	25	8	)	)	-RRB-
cord-310748-ao29zx1u	25	9	and	and	CC
cord-310748-ao29zx1u	25	10	poliovirus	poliovirus	NN
cord-310748-ao29zx1u	25	11	have	have	VBP
cord-310748-ao29zx1u	25	12	some	some	DT
cord-310748-ao29zx1u	25	13	apparent	apparent	JJ
cord-310748-ao29zx1u	25	14	recombinational	recombinational	JJ
cord-310748-ao29zx1u	25	15	hot	hot	JJ
cord-310748-ao29zx1u	25	16	spots	spot	NNS
cord-310748-ao29zx1u	25	17	(	(	-LRB-
cord-310748-ao29zx1u	25	18	72	72	CD
cord-310748-ao29zx1u	25	19	,	,	,
cord-310748-ao29zx1u	25	20	13	13	CD
cord-310748-ao29zx1u	25	21	)	)	-RRB-
cord-310748-ao29zx1u	25	22	.	.	.
cord-310748-ao29zx1u	26	1	Conceivably	conceivably	RB
cord-310748-ao29zx1u	26	2	,	,	,
cord-310748-ao29zx1u	26	3	the	the	DT
cord-310748-ao29zx1u	26	4	limitation	limitation	NN
cord-310748-ao29zx1u	26	5	andclusteringof	andclusteringof	NNP
cord-310748-ao29zx1u	26	6	recombination	recombination	NN
cord-310748-ao29zx1u	26	7	sites	site	NNS
cord-310748-ao29zx1u	26	8	in	in	IN
cord-310748-ao29zx1u	26	9	these	these	DT
cord-310748-ao29zx1u	26	10	viruses	virus	NNS
cord-310748-ao29zx1u	26	11	and	and	CC
cord-310748-ao29zx1u	26	12	the	the	DT
cord-310748-ao29zx1u	26	13	#	#	$
cord-310748-ao29zx1u	26	14	ailure	ailure	NN
cord-310748-ao29zx1u	26	15	to	to	TO
cord-310748-ao29zx1u	26	16	detect	detect	VB
cord-310748-ao29zx1u	26	17	recombinants	recombinant	NNS
cord-310748-ao29zx1u	26	18	in	in	IN
cord-310748-ao29zx1u	26	19	other	other	JJ
cord-310748-ao29zx1u	26	20	RNA	RNA	NNP
cord-310748-ao29zx1u	26	21	viruses	virus	NNS
cord-310748-ao29zx1u	26	22	coufd	coufd	NNP
cord-310748-ao29zx1u	26	23	very	very	RB
cord-310748-ao29zx1u	26	24	welt	welt	NN
cord-310748-ao29zx1u	26	25	be	be	VBP
cord-310748-ao29zx1u	26	26	the	the	DT
cord-310748-ao29zx1u	26	27	result	result	NN
cord-310748-ao29zx1u	26	28	of	of	IN
cord-310748-ao29zx1u	26	29	selection	selection	NN
cord-310748-ao29zx1u	26	30	for	for	IN
cord-310748-ao29zx1u	26	31	or	or	CC
cord-310748-ao29zx1u	26	32	against	against	IN
cord-310748-ao29zx1u	26	33	oertain	oertain	JJ
cord-310748-ao29zx1u	26	34	recombinants	recombinant	NNS
cord-310748-ao29zx1u	26	35	,	,	,
cord-310748-ao29zx1u	26	36	and	and	CC
cord-310748-ao29zx1u	26	37	may	may	MD
cord-310748-ao29zx1u	26	38	not	not	RB
cord-310748-ao29zx1u	26	39	necessarily	necessarily	RB
cord-310748-ao29zx1u	26	40	reflect	reflect	VB
cord-310748-ao29zx1u	26	41	the	the	DT
cord-310748-ao29zx1u	26	42	actual	actual	JJ
cord-310748-ao29zx1u	26	43	mechanism	mechanism	NN
cord-310748-ao29zx1u	26	44	of	of	IN
cord-310748-ao29zx1u	26	45	RNA	RNA	NNP
cord-310748-ao29zx1u	26	46	recombination	recombination	NN
cord-310748-ao29zx1u	26	47	or	or	CC
cord-310748-ao29zx1u	26	48	the	the	DT
cord-310748-ao29zx1u	26	49	lack	lack	NN
cord-310748-ao29zx1u	26	50	thereof	thereof	RB
cord-310748-ao29zx1u	26	51	.	.	.
cord-310748-ao29zx1u	27	1	To	to	TO
cord-310748-ao29zx1u	27	2	examine	examine	VB
cord-310748-ao29zx1u	27	3	this	this	DT
cord-310748-ao29zx1u	27	4	issue	issue	NN
cord-310748-ao29zx1u	27	5	,	,	,
cord-310748-ao29zx1u	27	6	we	-PRON-	PRP
cord-310748-ao29zx1u	27	7	initiated	initiate	VBD
cord-310748-ao29zx1u	27	8	a	a	DT
cord-310748-ao29zx1u	27	9	study	study	NN
cord-310748-ao29zx1u	27	10	of	of	IN
cord-310748-ao29zx1u	27	11	RNA	RNA	NNP
cord-310748-ao29zx1u	27	12	recombination	recombination	NN
cord-310748-ao29zx1u	27	13	in	in	IN
cord-310748-ao29zx1u	27	14	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	27	15	,	,	,
cord-310748-ao29zx1u	27	16	in	in	IN
cord-310748-ao29zx1u	27	17	the	the	DT
cord-310748-ao29zx1u	27	18	absence	absence	NN
cord-310748-ao29zx1u	27	19	of	of	IN
cord-310748-ao29zx1u	27	20	selection	selection	NN
cord-310748-ao29zx1u	27	21	pressure	pressure	NN
cord-310748-ao29zx1u	27	22	.	.	.
cord-310748-ao29zx1u	28	1	Surprisingly	surprisingly	RB
cord-310748-ao29zx1u	28	2	,	,	,
cord-310748-ao29zx1u	28	3	we	-PRON-	PRP
cord-310748-ao29zx1u	28	4	found	find	VBD
cord-310748-ao29zx1u	28	5	that	that	IN
cord-310748-ao29zx1u	28	6	the	the	DT
cord-310748-ao29zx1u	28	7	initial	initial	JJ
cord-310748-ao29zx1u	28	8	recombination	recombination	NN
cord-310748-ao29zx1u	28	9	events	event	NNS
cord-310748-ao29zx1u	28	10	within	within	IN
cord-310748-ao29zx1u	28	11	a	a	DT
cord-310748-ao29zx1u	28	12	1-kb	1-kb	CD
cord-310748-ao29zx1u	28	13	region	region	NN
cord-310748-ao29zx1u	28	14	of	of	IN
cord-310748-ao29zx1u	28	15	the	the	DT
cord-310748-ao29zx1u	28	16	peplomer	peplomer	JJ
cord-310748-ao29zx1u	28	17	gene	gene	NN
cord-310748-ao29zx1u	28	18	were	be	VBD
cord-310748-ao29zx1u	28	19	almost	almost	RB
cord-310748-ao29zx1u	28	20	entirely	entirely	RB
cord-310748-ao29zx1u	28	21	random	random	JJ
cord-310748-ao29zx1u	28	22	.	.	.
cord-310748-ao29zx1u	29	1	Howevar	Howevar	NNP
cord-310748-ao29zx1u	29	2	,	,	,
cord-310748-ao29zx1u	29	3	after	after	IN
cord-310748-ao29zx1u	29	4	only	only	RB
cord-310748-ao29zx1u	29	5	a	a	DT
cord-310748-ao29zx1u	29	6	few	few	JJ
cord-310748-ao29zx1u	29	7	passages	passage	NNS
cord-310748-ao29zx1u	29	8	,	,	,
cord-310748-ao29zx1u	29	9	the	the	DT
cord-310748-ao29zx1u	29	10	region	region	NN
cord-310748-ao29zx1u	29	11	in	in	IN
cord-310748-ao29zx1u	29	12	which	which	WDT
cord-310748-ao29zx1u	29	13	recombination	recombination	NN
cord-310748-ao29zx1u	29	14	could	could	MD
cord-310748-ao29zx1u	29	15	be	be	VB
cord-310748-ao29zx1u	29	16	detected	detect	VBN
cord-310748-ao29zx1u	29	17	became	become	VBD
cord-310748-ao29zx1u	29	18	restricted	restrict	VBN
cord-310748-ao29zx1u	29	19	,	,	,
cord-310748-ao29zx1u	29	20	such	such	JJ
cord-310748-ao29zx1u	29	21	that	that	IN
cord-310748-ao29zx1u	29	22	the	the	DT
cord-310748-ao29zx1u	29	23	majority	majority	NN
cord-310748-ao29zx1u	29	24	of	of	IN
cord-310748-ao29zx1u	29	25	crossover	crossover	NN
cord-310748-ao29zx1u	29	26	sites	site	NNS
cord-310748-ao29zx1u	29	27	were	be	VBD
cord-310748-ao29zx1u	29	28	locatized	locatize	VBN
cord-310748-ao29zx1u	29	29	to	to	IN
cord-310748-ao29zx1u	29	30	a	a	DT
cord-310748-ao29zx1u	29	31	small	small	JJ
cord-310748-ao29zx1u	29	32	area	area	NN
cord-310748-ao29zx1u	29	33	of	of	IN
cord-310748-ao29zx1u	29	34	the	the	DT
cord-310748-ao29zx1u	29	35	region	region	NN
cord-310748-ao29zx1u	29	36	examined	examine	VBD
cord-310748-ao29zx1u	29	37	.	.	.
cord-310748-ao29zx1u	30	1	Eventually	eventually	RB
cord-310748-ao29zx1u	30	2	,	,	,
cord-310748-ao29zx1u	30	3	all	all	PDT
cord-310748-ao29zx1u	30	4	the	the	DT
cord-310748-ao29zx1u	30	5	recombinants	recombinant	NNS
cord-310748-ao29zx1u	30	6	became	become	VBD
cord-310748-ao29zx1u	30	7	undetectable	undetectable	JJ
cord-310748-ao29zx1u	30	8	.	.	.
cord-310748-ao29zx1u	31	1	Our	-PRON-	PRP$
cord-310748-ao29zx1u	31	2	results	result	NNS
cord-310748-ao29zx1u	31	3	suggest	suggest	VBP
cord-310748-ao29zx1u	31	4	that	that	IN
cord-310748-ao29zx1u	31	5	RNA	RNA	NNP
cord-310748-ao29zx1u	31	6	recombination	recombination	NN
cord-310748-ao29zx1u	31	7	is	be	VBZ
cord-310748-ao29zx1u	31	8	more	more	RBR
cord-310748-ao29zx1u	31	9	common	common	JJ
cord-310748-ao29zx1u	31	10	than	than	IN
cord-310748-ao29zx1u	31	11	previously	previously	RB
cord-310748-ao29zx1u	31	12	recognized	recognize	VBN
cord-310748-ao29zx1u	31	13	and	and	CC
cord-310748-ao29zx1u	31	14	that	that	IN
cord-310748-ao29zx1u	31	15	the	the	DT
cord-310748-ao29zx1u	31	16	failure	failure	NN
cord-310748-ao29zx1u	31	17	to	to	TO
cord-310748-ao29zx1u	31	18	detect	detect	VB
cord-310748-ao29zx1u	31	19	recombinants	recombinant	NNS
cord-310748-ao29zx1u	31	20	in	in	IN
cord-310748-ao29zx1u	31	21	certain	certain	JJ
cord-310748-ao29zx1u	31	22	RNA	RNA	NNP
cord-310748-ao29zx1u	31	23	viruses	virus	NNS
cord-310748-ao29zx1u	31	24	may	may	MD
cord-310748-ao29zx1u	31	25	be	be	VB
cord-310748-ao29zx1u	31	26	due	due	JJ
cord-310748-ao29zx1u	31	27	to	to	IN
cord-310748-ao29zx1u	31	28	a	a	DT
cord-310748-ao29zx1u	31	29	negative	negative	JJ
cord-310748-ao29zx1u	31	30	selection	selection	NN
cord-310748-ao29zx1u	31	31	against	against	IN
cord-310748-ao29zx1u	31	32	recombinant	recombinant	JJ
cord-310748-ao29zx1u	31	33	viruses	virus	NNS
cord-310748-ao29zx1u	31	34	.	.	.
cord-310748-ao29zx1u	32	1	MHV	MHV	NNP
cord-310748-ao29zx1u	32	2	,	,	,
cord-310748-ao29zx1u	32	3	a	a	DT
cord-310748-ao29zx1u	32	4	prototypic	prototypic	JJ
cord-310748-ao29zx1u	32	5	member	member	NN
cord-310748-ao29zx1u	32	6	of	of	IN
cord-310748-ao29zx1u	32	7	the	the	DT
cord-310748-ao29zx1u	32	8	Coronaviridae	Coronaviridae	NNP
cord-310748-ao29zx1u	32	9	,	,	,
cord-310748-ao29zx1u	32	10	was	be	VBD
cord-310748-ao29zx1u	32	11	used	use	VBN
cord-310748-ao29zx1u	32	12	as	as	IN
cord-310748-ao29zx1u	32	13	a	a	DT
cord-310748-ao29zx1u	32	14	model	model	NN
cord-310748-ao29zx1u	32	15	system	system	NN
cord-310748-ao29zx1u	32	16	for	for	IN
cord-310748-ao29zx1u	32	17	the	the	DT
cord-310748-ao29zx1u	32	18	study	study	NN
cord-310748-ao29zx1u	32	19	of	of	IN
cord-310748-ao29zx1u	32	20	RNA	RNA	NNP
cord-310748-ao29zx1u	32	21	recombination	recombination	NN
cord-310748-ao29zx1u	32	22	.	.	.
cord-310748-ao29zx1u	33	1	MHV	MHV	NNP
cord-310748-ao29zx1u	33	2	contains	contain	VBZ
cord-310748-ao29zx1u	33	3	a	a	DT
cord-310748-ao29zx1u	33	4	positive	positive	JJ
cord-310748-ao29zx1u	33	5	-	-	HYPH
cord-310748-ao29zx1u	33	6	sense	sense	NN
cord-310748-ao29zx1u	33	7	RNA	RNA	NNP
cord-310748-ao29zx1u	33	8	genome	genome	NN
cord-310748-ao29zx1u	33	9	of	of	IN
cord-310748-ao29zx1u	33	10	31	31	CD
cord-310748-ao29zx1u	33	11	kb	kb	NNP
cord-310748-ao29zx1u	33	12	(	(	-LRB-
cord-310748-ao29zx1u	33	13	14	14	CD
cord-310748-ao29zx1u	33	14	,	,	,
cord-310748-ao29zx1u	33	15	16	16	CD
cord-310748-ao29zx1u	33	16	)	)	-RRB-
cord-310748-ao29zx1u	33	17	which	which	WDT
cord-310748-ao29zx1u	33	18	has	have	VBZ
cord-310748-ao29zx1u	33	19	been	be	VBN
cord-310748-ao29zx1u	33	20	shown	show	VBN
cord-310748-ao29zx1u	33	21	to	to	TO
cord-310748-ao29zx1u	33	22	undergo	undergo	VB
cord-310748-ao29zx1u	33	23	recombination	recombination	NN
cord-310748-ao29zx1u	33	24	both	both	DT
cord-310748-ao29zx1u	33	25	in	in	IN
cord-310748-ao29zx1u	33	26	vitro	vitro	FW
cord-310748-ao29zx1u	33	27	(	(	-LRB-
cord-310748-ao29zx1u	33	28	#	#	$
cord-310748-ao29zx1u	33	29	,	,	,
cord-310748-ao29zx1u	33	30	5	5	CD
cord-310748-ao29zx1u	33	31	,	,	,
cord-310748-ao29zx1u	33	32	17	17	CD
cord-310748-ao29zx1u	33	33	,	,	,
cord-310748-ao29zx1u	33	34	18	18	CD
cord-310748-ao29zx1u	33	35	)	)	-RRB-
cord-310748-ao29zx1u	33	36	and	and	CC
cord-310748-ao29zx1u	33	37	in	in	IN
cord-310748-ao29zx1u	33	38	viva	viva	FW
cord-310748-ao29zx1u	33	39	(	(	-LRB-
cord-310748-ao29zx1u	33	40	16	16	CD
cord-310748-ao29zx1u	33	41	)	)	-RRB-
cord-310748-ao29zx1u	33	42	at	at	IN
cord-310748-ao29zx1u	33	43	a	a	DT
cord-310748-ao29zx1u	33	44	frequency	frequency	NN
cord-310748-ao29zx1u	33	45	approaching	approach	VBG
cord-310748-ao29zx1u	33	46	25	25	CD
cord-310748-ao29zx1u	33	47	%	%	NN
cord-310748-ao29zx1u	33	48	for	for	IN
cord-310748-ao29zx1u	33	49	the	the	DT
cord-310748-ao29zx1u	33	50	entire	entire	JJ
cord-310748-ao29zx1u	33	51	genome	genome	NN
cord-310748-ao29zx1u	33	52	(	(	-LRB-
cord-310748-ao29zx1u	33	53	79	79	CD
cord-310748-ao29zx1u	33	54	)	)	-RRB-
cord-310748-ao29zx1u	33	55	.	.	.
cord-310748-ao29zx1u	34	1	To	to	TO
cord-310748-ao29zx1u	34	2	study	study	VB
cord-310748-ao29zx1u	34	3	RNA	RNA	NNP
cord-310748-ao29zx1u	34	4	recombination	recombination	NN
cord-310748-ao29zx1u	34	5	in	in	IN
cord-310748-ao29zx1u	34	6	the	the	DT
cord-310748-ao29zx1u	34	7	absence	absence	NN
cord-310748-ao29zx1u	34	8	of	of	IN
cord-310748-ao29zx1u	34	9	selection	selection	NN
cord-310748-ao29zx1u	34	10	pressure	pressure	NN
cord-310748-ao29zx1u	34	11	,	,	,
cord-310748-ao29zx1u	34	12	we	-PRON-	PRP
cord-310748-ao29zx1u	34	13	developed	develop	VBD
cord-310748-ao29zx1u	34	14	a	a	DT
cord-310748-ao29zx1u	34	15	polymer	polymer	NN
cord-310748-ao29zx1u	34	16	-	-	HYPH
cord-310748-ao29zx1u	34	17	ase	ase	NN
cord-310748-ao29zx1u	34	18	chain	chain	NN
cord-310748-ao29zx1u	34	19	reaction	reaction	NN
cord-310748-ao29zx1u	34	20	(	(	-LRB-
cord-310748-ao29zx1u	34	21	PCR	PCR	NNP
cord-310748-ao29zx1u	34	22	)	)	-RRB-
cord-310748-ao29zx1u	34	23	assay	assay	NN
cord-310748-ao29zx1u	34	24	using	use	VBG
cord-310748-ao29zx1u	34	25	two	two	CD
cord-310748-ao29zx1u	34	26	primers	primer	NNS
cord-310748-ao29zx1u	34	27	specific	specific	JJ
cord-310748-ao29zx1u	34	28	for	for	IN
cord-310748-ao29zx1u	34	29	the	the	DT
cord-310748-ao29zx1u	34	30	potential	potential	JJ
cord-310748-ao29zx1u	34	31	recombinant	recombinant	JJ
cord-310748-ao29zx1u	34	32	viruses	virus	NNS
cord-310748-ao29zx1u	34	33	which	which	WDT
cord-310748-ao29zx1u	34	34	have	have	VBP
cord-310748-ao29zx1u	34	35	a	a	DT
cord-310748-ao29zx1u	34	36	crossover	crossover	NN
cord-310748-ao29zx1u	34	37	site	site	NN
cord-310748-ao29zx1u	34	38	between	between	IN
cord-310748-ao29zx1u	34	39	the	the	DT
cord-310748-ao29zx1u	34	40	two	two	CD
cord-310748-ao29zx1u	34	41	primers	primer	NNS
cord-310748-ao29zx1u	34	42	.	.	.
cord-310748-ao29zx1u	35	1	We	-PRON-	PRP
cord-310748-ao29zx1u	35	2	first	first	RB
cord-310748-ao29zx1u	35	3	attempted	attempt	VBD
cord-310748-ao29zx1u	35	4	to	to	TO
cord-310748-ao29zx1u	35	5	detect	detect	VB
cord-310748-ao29zx1u	35	6	recombinant	recombinant	JJ
cord-310748-ao29zx1u	35	7	RNA	rna	NN
cord-310748-ao29zx1u	35	8	among	among	IN
cord-310748-ao29zx1u	35	9	the	the	DT
cord-310748-ao29zx1u	35	10	intracellular	intracellular	JJ
cord-310748-ao29zx1u	35	11	viral	viral	JJ
cord-310748-ao29zx1u	35	12	RNAs	rna	NNS
cord-310748-ao29zx1u	35	13	in	in	IN
cord-310748-ao29zx1u	35	14	cells	cell	NNS
cord-310748-ao29zx1u	35	15	coinfected	coinfecte	VBD
cord-310748-ao29zx1u	35	16	with	with	IN
cord-310748-ao29zx1u	35	17	two	two	CD
cord-310748-ao29zx1u	35	18	MHV	MHV	NNP
cord-310748-ao29zx1u	35	19	strains	strain	NNS
cord-310748-ao29zx1u	35	20	.	.	.
cord-310748-ao29zx1u	36	1	DBT	DBT	NNP
cord-310748-ao29zx1u	36	2	cells	cell	NNS
cord-310748-ao29zx1u	36	3	,	,	,
cord-310748-ao29zx1u	36	4	a	a	DT
cord-310748-ao29zx1u	36	5	murine	murine	JJ
cord-310748-ao29zx1u	36	6	astrocytoma	astrocytoma	NN
cord-310748-ao29zx1u	36	7	cell	cell	NN
cord-310748-ao29zx1u	36	8	line	line	NN
cord-310748-ao29zx1u	36	9	(	(	-LRB-
cord-310748-ao29zx1u	36	10	20	20	CD
cord-310748-ao29zx1u	36	11	)	)	-RRB-
cord-310748-ao29zx1u	36	12	were	be	VBD
cord-310748-ao29zx1u	36	13	coinfected	coinfecte	VBN
cord-310748-ao29zx1u	36	14	with	with	IN
cord-310748-ao29zx1u	36	15	the	the	DT
cord-310748-ao29zx1u	36	16	A59	A59	NNP
cord-310748-ao29zx1u	36	17	and	and	CC
cord-310748-ao29zx1u	36	18	JHM	JHM	NNP
cord-310748-ao29zx1u	36	19	-	-	HYPH
cord-310748-ao29zx1u	36	20	DL	DL	NNP
cord-310748-ao29zx1u	36	21	(	(	-LRB-
cord-310748-ao29zx1u	36	22	21	21	CD
cord-310748-ao29zx1u	36	23	)	)	-RRB-
cord-310748-ao29zx1u	36	24	strains	strain	NNS
cord-310748-ao29zx1u	36	25	of	of	IN
cord-310748-ao29zx1u	36	26	MHV	MHV	NNP
cord-310748-ao29zx1u	36	27	at	at	IN
cord-310748-ao29zx1u	36	28	a	a	DT
cord-310748-ao29zx1u	36	29	multiplicity	multiplicity	NN
cord-310748-ao29zx1u	36	30	of	of	IN
cord-310748-ao29zx1u	36	31	infection	infection	NN
cord-310748-ao29zx1u	36	32	(	(	-LRB-
cord-310748-ao29zx1u	36	33	m.0.i	m.0.i	NNP
cord-310748-ao29zx1u	36	34	.	.	.
cord-310748-ao29zx1u	36	35	)	)	-RRB-
cord-310748-ao29zx1u	37	1	of	of	IN
cord-310748-ao29zx1u	37	2	5	5	CD
cord-310748-ao29zx1u	37	3	.	.	.
cord-310748-ao29zx1u	38	1	At	at	IN
cord-310748-ao29zx1u	38	2	7	7	CD
cord-310748-ao29zx1u	38	3	hr	hr	NN
cord-310748-ao29zx1u	38	4	postinfection	postinfection	NN
cord-310748-ao29zx1u	38	5	,	,	,
cord-310748-ao29zx1u	38	6	cells	cell	NNS
cord-310748-ao29zx1u	38	7	were	be	VBD
cord-310748-ao29zx1u	38	8	lysed	lyse	VBN
cord-310748-ao29zx1u	38	9	with	with	IN
cord-310748-ao29zx1u	38	10	0.5	0.5	CD
cord-310748-ao29zx1u	38	11	%	%	NN
cord-310748-ao29zx1u	38	12	NP-40	NP-40	NNP
cord-310748-ao29zx1u	38	13	;	;	:
cord-310748-ao29zx1u	38	14	total	total	JJ
cord-310748-ao29zx1u	38	15	RNA	RNA	NNP
cord-310748-ao29zx1u	38	16	was	be	VBD
cord-310748-ao29zx1u	38	17	extracted	extract	VBN
cord-310748-ao29zx1u	38	18	and	and	CC
cord-310748-ao29zx1u	38	19	treated	treat	VBN
cord-310748-ao29zx1u	38	20	with	with	IN
cord-310748-ao29zx1u	38	21	proteinase	proteinase	NN
cord-310748-ao29zx1u	38	22	K	K	NNP
cord-310748-ao29zx1u	38	23	,	,	,
cord-310748-ao29zx1u	38	24	and	and	CC
cord-310748-ao29zx1u	38	25	polyA	polyA	NNP
cord-310748-ao29zx1u	38	26	-	-	HYPH
cord-310748-ao29zx1u	38	27	containing	contain	VBG
cord-310748-ao29zx1u	38	28	RNA	RNA	NNP
cord-310748-ao29zx1u	38	29	was	be	VBD
cord-310748-ao29zx1u	38	30	selected	select	VBN
cord-310748-ao29zx1u	38	31	.	.	.
cord-310748-ao29zx1u	39	1	We	-PRON-	PRP
cord-310748-ao29zx1u	39	2	chose	choose	VBD
cord-310748-ao29zx1u	39	3	the	the	DT
cord-310748-ao29zx1u	39	4	peplomer	peplomer	NNP
cord-310748-ao29zx1u	39	5	(	(	-LRB-
cord-310748-ao29zx1u	39	6	S	S	NNP
cord-310748-ao29zx1u	39	7	)	)	-RRB-
cord-310748-ao29zx1u	39	8	gene	gene	NN
cord-310748-ao29zx1u	39	9	for	for	IN
cord-310748-ao29zx1u	39	10	this	this	DT
cord-310748-ao29zx1u	39	11	study	study	NN
cord-310748-ao29zx1u	39	12	,	,	,
cord-310748-ao29zx1u	39	13	since	since	IN
cord-310748-ao29zx1u	39	14	several	several	JJ
cord-310748-ao29zx1u	39	15	recombinants	recombinant	NNS
cord-310748-ao29zx1u	39	16	isolated	isolate	VBN
cord-310748-ao29zx1u	39	17	using	use	VBG
cord-310748-ao29zx1u	39	18	selection	selection	NN
cord-310748-ao29zx1u	39	19	markers	marker	NNS
cord-310748-ao29zx1u	39	20	have	have	VBP
cord-310748-ao29zx1u	39	21	been	be	VBN
cord-310748-ao29zx1u	39	22	shown	show	VBN
cord-310748-ao29zx1u	39	23	to	to	TO
cord-310748-ao29zx1u	39	24	contain	contain	VB
cord-310748-ao29zx1u	39	25	crossover	crossover	NN
cord-310748-ao29zx1u	39	26	sites	site	NNS
cord-310748-ao29zx1u	39	27	within	within	IN
cord-310748-ao29zx1u	39	28	this	this	DT
cord-310748-ao29zx1u	39	29	gene	gene	NN
cord-310748-ao29zx1u	39	30	(	(	-LRB-
cord-310748-ao29zx1u	39	31	12	12	CD
cord-310748-ao29zx1u	39	32	)	)	-RRB-
cord-310748-ao29zx1u	39	33	.	.	.
cord-310748-ao29zx1u	40	1	Two	two	CD
cord-310748-ao29zx1u	40	2	synthetic	synthetic	JJ
cord-310748-ao29zx1u	40	3	oligonucleotides	oligonucleotide	NNS
cord-310748-ao29zx1u	40	4	specific	specific	JJ
cord-310748-ao29zx1u	40	5	for	for	IN
cord-310748-ao29zx1u	40	6	the	the	DT
cord-310748-ao29zx1u	40	7	recombinants	recombinant	NNS
cord-310748-ao29zx1u	40	8	were	be	VBD
cord-310748-ao29zx1u	40	9	used	use	VBN
cord-310748-ao29zx1u	40	10	as	as	IN
cord-310748-ao29zx1u	40	11	primers	primer	NNS
cord-310748-ao29zx1u	40	12	.	.	.
cord-310748-ao29zx1u	41	1	A	a	DT
cord-310748-ao29zx1u	41	2	JHM	JHM	NNP
cord-310748-ao29zx1u	41	3	-	-	HYPH
cord-310748-ao29zx1u	41	4	DL	dl	NN
cord-310748-ao29zx1u	41	5	-	-	HYPH
cord-310748-ao29zx1u	41	6	specific	specific	JJ
cord-310748-ao29zx1u	41	7	primer	primer	NN
cord-310748-ao29zx1u	41	8	(	(	-LRB-
cord-310748-ao29zx1u	41	9	5'-CGCGATCCGTGCACATCCAAGG-3	5'-cgcgatccgtgcacatccaagg-3	CD
cord-310748-ao29zx1u	41	10	'	'	''
cord-310748-ao29zx1u	41	11	)	)	-RRB-
cord-310748-ao29zx1u	41	12	which	which	WDT
cord-310748-ao29zx1u	41	13	bound	bind	VBN
cord-310748-ao29zx1u	41	14	to	to	TO
cord-310748-ao29zx1u	41	15	position	position	VB
cord-310748-ao29zx1u	41	16	1554	1554	CD
cord-310748-ao29zx1u	41	17	-	-	SYM
cord-310748-ao29zx1u	41	18	1575	1575	CD
cord-310748-ao29zx1u	41	19	from	from	IN
cord-310748-ao29zx1u	41	20	the	the	DT
cord-310748-ao29zx1u	41	21	5'-end	5'-end	CD
cord-310748-ao29zx1u	41	22	of	of	IN
cord-310748-ao29zx1u	41	23	the	the	DT
cord-310748-ao29zx1u	41	24	peplomer	peplomer	NNP
cord-310748-ao29zx1u	41	25	gene	gene	NN
cord-310748-ao29zx1u	41	26	,	,	,
cord-310748-ao29zx1u	41	27	was	be	VBD
cord-310748-ao29zx1u	41	28	used	use	VBN
cord-310748-ao29zx1u	41	29	for	for	IN
cord-310748-ao29zx1u	41	30	first	first	JJ
cord-310748-ao29zx1u	41	31	-	-	HYPH
cord-310748-ao29zx1u	41	32	strand	strand	NN
cord-310748-ao29zx1u	41	33	cDNA	cdna	NN
cord-310748-ao29zx1u	41	34	synthesis	synthesis	NN
cord-310748-ao29zx1u	41	35	.	.	.
cord-310748-ao29zx1u	42	1	This	this	DT
cord-310748-ao29zx1u	42	2	primer	primer	NN
cord-310748-ao29zx1u	42	3	corresponds	correspond	VBZ
cord-310748-ao29zx1u	42	4	to	to	IN
cord-310748-ao29zx1u	42	5	a	a	DT
cord-310748-ao29zx1u	42	6	region	region	NN
cord-310748-ao29zx1u	42	7	which	which	WDT
cord-310748-ao29zx1u	42	8	is	be	VBZ
cord-310748-ao29zx1u	42	9	deleted	delete	VBN
cord-310748-ao29zx1u	42	10	in	in	IN
cord-310748-ao29zx1u	42	11	A59	A59	NNP
cord-310748-ao29zx1u	42	12	(	(	-LRB-
cord-310748-ao29zx1u	42	13	12	12	CD
cord-310748-ao29zx1u	42	14	,	,	,
cord-310748-ao29zx1u	42	15	22	22	CD
cord-310748-ao29zx1u	42	16	)	)	-RRB-
cord-310748-ao29zx1u	42	17	and	and	CC
cord-310748-ao29zx1u	42	18	,	,	,
cord-310748-ao29zx1u	42	19	thus	thus	RB
cord-310748-ao29zx1u	42	20	,	,	,
cord-310748-ao29zx1u	42	21	does	do	VBZ
cord-310748-ao29zx1u	42	22	not	not	RB
cord-310748-ao29zx1u	42	23	bind	bind	VB
cord-310748-ao29zx1u	42	24	to	to	IN
cord-310748-ao29zx1u	42	25	A59	A59	NNP
cord-310748-ao29zx1u	42	26	.	.	.
cord-310748-ao29zx1u	43	1	The	the	DT
cord-310748-ao29zx1u	43	2	cDNA	cdna	NN
cord-310748-ao29zx1u	43	3	was	be	VBD
cord-310748-ao29zx1u	43	4	then	then	RB
cord-310748-ao29zx1u	43	5	used	use	VBN
cord-310748-ao29zx1u	43	6	as	as	IN
cord-310748-ao29zx1u	43	7	template	template	NN
cord-310748-ao29zx1u	43	8	for	for	IN
cord-310748-ao29zx1u	43	9	amplification	amplification	NN
cord-310748-ao29zx1u	43	10	by	by	IN
cord-310748-ao29zx1u	43	11	PCR	PCR	NNP
cord-310748-ao29zx1u	43	12	,	,	,
cord-310748-ao29zx1u	43	13	along	along	IN
cord-310748-ao29zx1u	43	14	with	with	IN
cord-310748-ao29zx1u	43	15	an	an	DT
cord-310748-ao29zx1u	43	16	A59-specific	A59-specific	NNP
cord-310748-ao29zx1u	43	17	second	second	JJ
cord-310748-ao29zx1u	43	18	primer	primer	NN
cord-310748-ao29zx1u	43	19	(	(	-LRB-
cord-310748-ao29zx1u	43	20	5'-GGACTGAGCTCCGCT	5'-ggactgagctccgct	CD
cord-310748-ao29zx1u	43	21	-	-	HYPH
cord-310748-ao29zx1u	43	22	TAATGTTAATGGCTGATG	TAATGTTAATGGCTGATG	NNP
cord-310748-ao29zx1u	43	23	-	-	HYPH
cord-310748-ao29zx1u	43	24	CAT-3	CAT-3	NNP
cord-310748-ao29zx1u	43	25	'	'	''
cord-310748-ao29zx1u	43	26	)	)	-RRB-
cord-310748-ao29zx1u	43	27	which	which	WDT
cord-310748-ao29zx1u	43	28	bound	bind	VBN
cord-310748-ao29zx1u	43	29	at	at	IN
cord-310748-ao29zx1u	43	30	position	position	NN
cord-310748-ao29zx1u	43	31	581	581	CD
cord-310748-ao29zx1u	43	32	-	-	SYM
cord-310748-ao29zx1u	43	33	604	604	CD
cord-310748-ao29zx1u	43	34	of	of	IN
cord-310748-ao29zx1u	43	35	the	the	DT
cord-310748-ao29zx1u	43	36	peplomer	peplomer	NNP
cord-310748-ao29zx1u	43	37	gene	gene	NN
cord-310748-ao29zx1u	43	38	.	.	.
cord-310748-ao29zx1u	44	1	Seven	seven	CD
cord-310748-ao29zx1u	44	2	of	of	IN
cord-310748-ao29zx1u	44	3	eight	eight	CD
cord-310748-ao29zx1u	44	4	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	44	5	at	at	IN
cord-310748-ao29zx1u	44	6	the	the	DT
cord-310748-ao29zx1u	44	7	3'-end	3'-end	CD
cord-310748-ao29zx1u	44	8	of	of	IN
cord-310748-ao29zx1u	44	9	this	this	DT
cord-310748-ao29zx1u	44	10	primer	primer	NN
cord-310748-ao29zx1u	44	11	differ	differ	VBP
cord-310748-ao29zx1u	44	12	from	from	IN
cord-310748-ao29zx1u	44	13	the	the	DT
cord-310748-ao29zx1u	44	14	corresponding	correspond	VBG
cord-310748-ao29zx1u	44	15	region	region	NN
cord-310748-ao29zx1u	44	16	of	of	IN
cord-310748-ao29zx1u	44	17	JHM	JHM	NNP
cord-310748-ao29zx1u	44	18	-	-	HYPH
cord-310748-ao29zx1u	44	19	DL	DL	NNP
cord-310748-ao29zx1u	44	20	.	.	.
cord-310748-ao29zx1u	45	1	The	the	DT
cord-310748-ao29zx1u	45	2	region	region	NN
cord-310748-ao29zx1u	45	3	between	between	IN
cord-310748-ao29zx1u	45	4	these	these	DT
cord-310748-ao29zx1u	45	5	two	two	CD
cord-310748-ao29zx1u	45	6	primers	primer	NNS
cord-310748-ao29zx1u	45	7	spanned	span	VBD
cord-310748-ao29zx1u	45	8	950	950	CD
cord-310748-ao29zx1u	45	9	nt	nt	RB
cord-310748-ao29zx1u	45	10	and	and	CC
cord-310748-ao29zx1u	45	11	included	include	VBD
cord-310748-ao29zx1u	45	12	a	a	DT
cord-310748-ao29zx1u	45	13	hypervariable	hypervariable	JJ
cord-310748-ao29zx1u	45	14	area	area	NN
cord-310748-ao29zx1u	45	15	which	which	WDT
cord-310748-ao29zx1u	45	16	is	be	VBZ
cord-310748-ao29zx1u	45	17	subject	subject	JJ
cord-310748-ao29zx1u	45	18	to	to	IN
cord-310748-ao29zx1u	45	19	frequent	frequent	JJ
cord-310748-ao29zx1u	45	20	deletions	deletion	NNS
cord-310748-ao29zx1u	45	21	(	(	-LRB-
cord-310748-ao29zx1u	45	22	72	72	CD
cord-310748-ao29zx1u	45	23	,	,	,
cord-310748-ao29zx1u	45	24	22	22	CD
cord-310748-ao29zx1u	45	25	)	)	-RRB-
cord-310748-ao29zx1u	45	26	and	and	CC
cord-310748-ao29zx1u	45	27	a	a	DT
cord-310748-ao29zx1u	45	28	previously	previously	RB
cord-310748-ao29zx1u	45	29	identified	identify	VBN
cord-310748-ao29zx1u	45	30	recombinational	recombinational	JJ
cord-310748-ao29zx1u	45	31	"	"	``
cord-310748-ao29zx1u	45	32	hot	hot	JJ
cord-310748-ao29zx1u	45	33	spot	spot	NN
cord-310748-ao29zx1u	45	34	"	"	''
cord-310748-ao29zx1u	45	35	between	between	IN
cord-310748-ao29zx1u	45	36	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	45	37	1148	1148	CD
cord-310748-ao29zx1u	45	38	and	and	CC
cord-310748-ao29zx1u	45	39	1426	1426	CD
cord-310748-ao29zx1u	45	40	(	(	-LRB-
cord-310748-ao29zx1u	45	41	12	12	CD
cord-310748-ao29zx1u	45	42	)	)	-RRB-
cord-310748-ao29zx1u	45	43	.	.	.
cord-310748-ao29zx1u	46	1	Only	only	RB
cord-310748-ao29zx1u	46	2	recombinant	recombinant	JJ
cord-310748-ao29zx1u	46	3	RNAs	rna	NNS
cord-310748-ao29zx1u	46	4	which	which	WDT
cord-310748-ao29zx1u	46	5	had	have	VBD
cord-310748-ao29zx1u	46	6	a	a	DT
cord-310748-ao29zx1u	46	7	crossover	crossover	NN
cord-310748-ao29zx1u	46	8	between	between	IN
cord-310748-ao29zx1u	46	9	the	the	DT
cord-310748-ao29zx1u	46	10	two	two	CD
cord-310748-ao29zx1u	46	11	primers	primer	NNS
cord-310748-ao29zx1u	46	12	and	and	CC
cord-310748-ao29zx1u	46	13	contained	contain	VBD
cord-310748-ao29zx1u	46	14	A59-specific	A59-specific	NNP
cord-310748-ao29zx1u	46	15	sequences	sequence	NNS
cord-310748-ao29zx1u	46	16	on	on	IN
cord-310748-ao29zx1u	46	17	the	the	DT
cord-310748-ao29zx1u	46	18	5'-side	5'-side	JJ
cord-310748-ao29zx1u	46	19	and	and	CC
cord-310748-ao29zx1u	46	20	JHM	JHM	NNP
cord-310748-ao29zx1u	46	21	-	-	HYPH
cord-310748-ao29zx1u	46	22	DL	dl	NN
cord-310748-ao29zx1u	46	23	-	-	HYPH
cord-310748-ao29zx1u	46	24	specific	specific	JJ
cord-310748-ao29zx1u	46	25	sequences	sequence	NNS
cord-310748-ao29zx1u	46	26	on	on	IN
cord-310748-ao29zx1u	46	27	the	the	DT
cord-310748-ao29zx1u	46	28	3'-side	3'-side	CD
cord-310748-ao29zx1u	46	29	could	could	MD
cord-310748-ao29zx1u	46	30	be	be	VB
cord-310748-ao29zx1u	46	31	detected	detect	VBN
cord-310748-ao29zx1u	46	32	by	by	IN
cord-310748-ao29zx1u	46	33	this	this	DT
cord-310748-ao29zx1u	46	34	PCR	PCR	NNP
cord-310748-ao29zx1u	46	35	approach	approach	NN
cord-310748-ao29zx1u	46	36	.	.	.
cord-310748-ao29zx1u	47	1	PCR	PCR	NNP
cord-310748-ao29zx1u	47	2	conditions	condition	NNS
cord-310748-ao29zx1u	47	3	were	be	VBD
cord-310748-ao29zx1u	47	4	chosen	choose	VBN
cord-310748-ao29zx1u	47	5	so	so	IN
cord-310748-ao29zx1u	47	6	that	that	IN
cord-310748-ao29zx1u	47	7	these	these	DT
cord-310748-ao29zx1u	47	8	two	two	CD
cord-310748-ao29zx1u	47	9	primers	primer	NNS
cord-310748-ao29zx1u	47	10	would	would	MD
cord-310748-ao29zx1u	47	11	bind	bind	VB
cord-310748-ao29zx1u	47	12	only	only	RB
cord-310748-ao29zx1u	47	13	to	to	IN
cord-310748-ao29zx1u	47	14	recombinant	recombinant	JJ
cord-310748-ao29zx1u	47	15	RNAs	rna	NNS
cord-310748-ao29zx1u	47	16	and	and	CC
cord-310748-ao29zx1u	47	17	would	would	MD
cord-310748-ao29zx1u	47	18	not	not	RB
cord-310748-ao29zx1u	47	19	generate	generate	VB
cord-310748-ao29zx1u	47	20	nonspecific	nonspecific	JJ
cord-310748-ao29zx1u	47	21	PCR	PCR	NNP
cord-310748-ao29zx1u	47	22	products	product	NNS
cord-310748-ao29zx1u	47	23	by	by	IN
cord-310748-ao29zx1u	47	24	reverse	reverse	JJ
cord-310748-ao29zx1u	47	25	transcriptase	transcriptase	NN
cord-310748-ao29zx1u	47	26	or	or	CC
cord-310748-ao29zx1u	47	27	Taq	taq	NN
cord-310748-ao29zx1u	47	28	polymerase	polymerase	NN
cord-310748-ao29zx1u	47	29	jumping	jumping	NN
cord-310748-ao29zx1u	47	30	.	.	.
cord-310748-ao29zx1u	48	1	RNA	RNA	NNP
cord-310748-ao29zx1u	48	2	was	be	VBD
cord-310748-ao29zx1u	48	3	amplified	amplify	VBN
cord-310748-ao29zx1u	48	4	by	by	IN
cord-310748-ao29zx1u	48	5	a	a	DT
cord-310748-ao29zx1u	48	6	slight	slight	JJ
cord-310748-ao29zx1u	48	7	modification	modification	NN
cord-310748-ao29zx1u	48	8	of	of	IN
cord-310748-ao29zx1u	48	9	the	the	DT
cord-310748-ao29zx1u	48	10	procedure	procedure	NN
cord-310748-ao29zx1u	48	11	of	of	IN
cord-310748-ao29zx1u	48	12	Fugue	Fugue	NNP
cord-310748-ao29zx1u	48	13	et	et	FW
cord-310748-ao29zx1u	48	14	a/.	a/.	NN
cord-310748-ao29zx1u	48	15	(	(	-LRB-
cord-310748-ao29zx1u	48	16	23	23	CD
cord-310748-ao29zx1u	48	17	)	)	-RRB-
cord-310748-ao29zx1u	48	18	.	.	.
cord-310748-ao29zx1u	49	1	Briefly	briefly	RB
cord-310748-ao29zx1u	49	2	,	,	,
cord-310748-ao29zx1u	49	3	1	1	CD
cord-310748-ao29zx1u	49	4	pg	pg	CD
cord-310748-ao29zx1u	49	5	of	of	IN
cord-310748-ao29zx1u	49	6	RNA	RNA	NNP
cord-310748-ao29zx1u	49	7	was	be	VBD
cord-310748-ao29zx1u	49	8	mixed	mix	VBN
cord-310748-ao29zx1u	49	9	with	with	IN
cord-310748-ao29zx1u	49	10	50	50	CD
cord-310748-ao29zx1u	49	11	ng	ng	NN
cord-310748-ao29zx1u	49	12	of	of	IN
cord-310748-ao29zx1u	49	13	the	the	DT
cord-310748-ao29zx1u	49	14	two	two	CD
cord-310748-ao29zx1u	49	15	appropriate	appropriate	JJ
cord-310748-ao29zx1u	49	16	primers	primer	NNS
cord-310748-ao29zx1u	49	17	in	in	IN
cord-310748-ao29zx1u	49	18	a	a	DT
cord-310748-ao29zx1u	49	19	1	1	CD
cord-310748-ao29zx1u	49	20	00-~1	00-~1	CD
cord-310748-ao29zx1u	49	21	reaction	reaction	NN
cord-310748-ao29zx1u	49	22	mixture	mixture	NN
cord-310748-ao29zx1u	49	23	containing	contain	VBG
cord-310748-ao29zx1u	49	24	10	10	CD
cord-310748-ao29zx1u	49	25	mM	mM	NNP
cord-310748-ao29zx1u	49	26	Tris	Tris	NNP
cord-310748-ao29zx1u	49	27	-	-	HYPH
cord-310748-ao29zx1u	49	28	HCI	HCI	NNP
cord-310748-ao29zx1u	49	29	(	(	-LRB-
cord-310748-ao29zx1u	49	30	pH	pH	NNP
cord-310748-ao29zx1u	49	31	8.0	8.0	CD
cord-310748-ao29zx1u	49	32	)	)	-RRB-
cord-310748-ao29zx1u	49	33	50	50	CD
cord-310748-ao29zx1u	49	34	mlM	mlM	NNP
cord-310748-ao29zx1u	49	35	KCI	KCI	NNP
cord-310748-ao29zx1u	49	36	,	,	,
cord-310748-ao29zx1u	49	37	3	3	CD
cord-310748-ao29zx1u	49	38	mM	mm	CD
cord-310748-ao29zx1u	49	39	MgCI	MgCI	NNP
cord-310748-ao29zx1u	49	40	,	,	,
cord-310748-ao29zx1u	49	41	,	,	,
cord-310748-ao29zx1u	49	42	0.01	0.01	CD
cord-310748-ao29zx1u	49	43	Oh	oh	UH
cord-310748-ao29zx1u	49	44	gelatin	gelatin	NN
cord-310748-ao29zx1u	49	45	,	,	,
cord-310748-ao29zx1u	49	46	500	500	CD
cord-310748-ao29zx1u	49	47	PM	pm	NN
cord-310748-ao29zx1u	49	48	each	each	DT
cord-310748-ao29zx1u	49	49	of	of	IN
cord-310748-ao29zx1u	49	50	the	the	DT
cord-310748-ao29zx1u	49	51	four	four	CD
cord-310748-ao29zx1u	49	52	deoxyribonucleoside	deoxyribonucleoside	JJ
cord-310748-ao29zx1u	49	53	triphosphates	triphosphate	NNS
cord-310748-ao29zx1u	49	54	,	,	,
cord-310748-ao29zx1u	49	55	and	and	CC
cord-310748-ao29zx1u	49	56	1	1	CD
cord-310748-ao29zx1u	49	57	pg	pg	NNP
cord-310748-ao29zx1u	49	58	tRNA	tRNA	NNP
cord-310748-ao29zx1u	49	59	as	as	IN
cord-310748-ao29zx1u	49	60	a	a	DT
cord-310748-ao29zx1u	49	61	nonspecific	nonspecific	JJ
cord-310748-ao29zx1u	49	62	competitor	competitor	NN
cord-310748-ao29zx1u	49	63	.	.	.
cord-310748-ao29zx1u	50	1	The	the	DT
cord-310748-ao29zx1u	50	2	RNA	RNA	NNP
cord-310748-ao29zx1u	50	3	was	be	VBD
cord-310748-ao29zx1u	50	4	denatured	denature	VBN
cord-310748-ao29zx1u	50	5	for	for	IN
cord-310748-ao29zx1u	50	6	2	2	CD
cord-310748-ao29zx1u	50	7	min	min	NN
cord-310748-ao29zx1u	50	8	at	at	IN
cord-310748-ao29zx1u	50	9	94	94	CD
cord-310748-ao29zx1u	50	10	"	"	''
cord-310748-ao29zx1u	50	11	and	and	CC
cord-310748-ao29zx1u	50	12	chilled	chill	VBD
cord-310748-ao29zx1u	50	13	quickly	quickly	RB
cord-310748-ao29zx1u	50	14	on	on	IN
cord-310748-ao29zx1u	50	15	ice	ice	NN
cord-310748-ao29zx1u	50	16	.	.	.
cord-310748-ao29zx1u	51	1	Two	two	CD
cord-310748-ao29zx1u	51	2	units	unit	NNS
cord-310748-ao29zx1u	51	3	of	of	IN
cord-310748-ao29zx1u	51	4	AMV	AMV	NNP
cord-310748-ao29zx1u	51	5	reverse	reverse	NN
cord-310748-ao29zx1u	51	6	transcriptase	transcriptase	NN
cord-310748-ao29zx1u	51	7	(	(	-LRB-
cord-310748-ao29zx1u	51	8	Seikagaku	Seikagaku	NNP
cord-310748-ao29zx1u	51	9	,	,	,
cord-310748-ao29zx1u	51	10	Rockville	Rockville	NNP
cord-310748-ao29zx1u	51	11	,	,	,
cord-310748-ao29zx1u	51	12	MD	MD	NNP
cord-310748-ao29zx1u	51	13	)	)	-RRB-
cord-310748-ao29zx1u	51	14	was	be	VBD
cord-310748-ao29zx1u	51	15	added	add	VBN
cord-310748-ao29zx1u	51	16	and	and	CC
cord-310748-ao29zx1u	51	17	the	the	DT
cord-310748-ao29zx1u	51	18	reaction	reaction	NN
cord-310748-ao29zx1u	51	19	incubated	incubate	VBD
cord-310748-ao29zx1u	51	20	for	for	IN
cord-310748-ao29zx1u	51	21	30	30	CD
cord-310748-ao29zx1u	51	22	min	min	NN
cord-310748-ao29zx1u	51	23	at	at	IN
cord-310748-ao29zx1u	51	24	42	42	CD
cord-310748-ao29zx1u	51	25	"	"	''
cord-310748-ao29zx1u	51	26	.	.	.
cord-310748-ao29zx1u	52	1	After	after	IN
cord-310748-ao29zx1u	52	2	the	the	DT
cord-310748-ao29zx1u	52	3	addition	addition	NN
cord-310748-ao29zx1u	52	4	of	of	IN
cord-310748-ao29zx1u	52	5	2	2	CD
cord-310748-ao29zx1u	52	6	units	unit	NNS
cord-310748-ao29zx1u	52	7	of	of	IN
cord-310748-ao29zx1u	52	8	Taq	Taq	NNP
cord-310748-ao29zx1u	52	9	DNA	dna	NN
cord-310748-ao29zx1u	52	10	polymerase	polymerase	NN
cord-310748-ao29zx1u	52	11	(	(	-LRB-
cord-310748-ao29zx1u	52	12	Perkin	Perkin	NNP
cord-310748-ao29zx1u	52	13	-	-	HYPH
cord-310748-ao29zx1u	52	14	Elmer	Elmer	NNP
cord-310748-ao29zx1u	52	15	Cetus	Cetus	NNP
cord-310748-ao29zx1u	52	16	,	,	,
cord-310748-ao29zx1u	52	17	Norwalk	Norwalk	NNP
cord-310748-ao29zx1u	52	18	,	,	,
cord-310748-ao29zx1u	52	19	CT	CT	NNP
cord-310748-ao29zx1u	52	20	)	)	-RRB-
cord-310748-ao29zx1u	52	21	,	,	,
cord-310748-ao29zx1u	52	22	the	the	DT
cord-310748-ao29zx1u	52	23	resulting	result	VBG
cord-310748-ao29zx1u	52	24	cDNA	cdna	NN
cord-310748-ao29zx1u	52	25	was	be	VBD
cord-310748-ao29zx1u	52	26	amplified	amplify	VBN
cord-310748-ao29zx1u	52	27	for	for	IN
cord-310748-ao29zx1u	52	28	35	35	CD
cord-310748-ao29zx1u	52	29	cycles	cycle	NNS
cord-310748-ao29zx1u	52	30	,	,	,
cord-310748-ao29zx1u	52	31	with	with	IN
cord-310748-ao29zx1u	52	32	each	each	DT
cord-310748-ao29zx1u	52	33	which	which	WDT
cord-310748-ao29zx1u	52	34	binds	bind	VBZ
cord-310748-ao29zx1u	52	35	at	at	IN
cord-310748-ao29zx1u	52	36	nucleotide	nucleotide	JJ
cord-310748-ao29zx1u	52	37	58	58	CD
cord-310748-ao29zx1u	52	38	l-604	l-604	NNS
cord-310748-ao29zx1u	52	39	.	.	.
cord-310748-ao29zx1u	53	1	Both	both	DT
cord-310748-ao29zx1u	53	2	primers	primer	NNS
cord-310748-ao29zx1u	53	3	were	be	VBD
cord-310748-ao29zx1u	53	4	specific	specific	JJ
cord-310748-ao29zx1u	53	5	for	for	IN
cord-310748-ao29zx1u	53	6	JHM	JHM	NNP
cord-310748-ao29zx1u	53	7	-	-	HYPH
cord-310748-ao29zx1u	53	8	DL	DL	NNP
cord-310748-ao29zx1u	53	9	.	.	.
cord-310748-ao29zx1u	54	1	Lane	lane	NN
cord-310748-ao29zx1u	54	2	3	3	CD
cord-310748-ao29zx1u	54	3	:	:	:
cord-310748-ao29zx1u	55	1	A59	A59	NNP
cord-310748-ao29zx1u	55	2	RNA	RNA	NNP
cord-310748-ao29zx1u	55	3	from	from	IN
cord-310748-ao29zx1u	55	4	a	a	DT
cord-310748-ao29zx1u	55	5	single	single	JJ
cord-310748-ao29zx1u	55	6	infection	infection	NN
cord-310748-ao29zx1u	55	7	was	be	VBD
cord-310748-ao29zx1u	55	8	used	use	VBN
cord-310748-ao29zx1u	55	9	as	as	IN
cord-310748-ao29zx1u	55	10	template	template	NN
cord-310748-ao29zx1u	55	11	for	for	IN
cord-310748-ao29zx1u	55	12	PCR	PCR	NNP
cord-310748-ao29zx1u	55	13	with	with	IN
cord-310748-ao29zx1u	55	14	primers	primer	NNS
cord-310748-ao29zx1u	55	15	109	109	CD
cord-310748-ao29zx1u	55	16	,	,	,
cord-310748-ao29zx1u	55	17	which	which	WDT
cord-310748-ao29zx1u	55	18	bound	bind	VBN
cord-310748-ao29zx1u	55	19	to	to	IN
cord-310748-ao29zx1u	55	20	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	55	21	1554	1554	CD
cord-310748-ao29zx1u	55	22	-	-	SYM
cord-310748-ao29zx1u	55	23	1575	1575	CD
cord-310748-ao29zx1u	55	24	,	,	,
cord-310748-ao29zx1u	55	25	and	and	CC
cord-310748-ao29zx1u	55	26	152	152	CD
cord-310748-ao29zx1u	55	27	,	,	,
cord-310748-ao29zx1u	55	28	which	which	WDT
cord-310748-ao29zx1u	55	29	were	be	VBD
cord-310748-ao29zx1u	55	30	specific	specific	JJ
cord-310748-ao29zx1u	55	31	for	for	IN
cord-310748-ao29zx1u	55	32	recombinants	recombinant	NNS
cord-310748-ao29zx1u	55	33	.	.	.
cord-310748-ao29zx1u	56	1	Lane	lane	NN
cord-310748-ao29zx1u	56	2	4	4	CD
cord-310748-ao29zx1u	56	3	:	:	:
cord-310748-ao29zx1u	56	4	JHM	JHM	NNP
cord-310748-ao29zx1u	56	5	-	-	HYPH
cord-310748-ao29zx1u	56	6	DL	DL	NNP
cord-310748-ao29zx1u	56	7	RNA	RNA	NNP
cord-310748-ao29zx1u	56	8	was	be	VBD
cord-310748-ao29zx1u	56	9	used	use	VBN
cord-310748-ao29zx1u	56	10	as	as	IN
cord-310748-ao29zx1u	56	11	template	template	NN
cord-310748-ao29zx1u	56	12	for	for	IN
cord-310748-ao29zx1u	56	13	PCR	PCR	NNP
cord-310748-ao29zx1u	56	14	with	with	IN
cord-310748-ao29zx1u	56	15	primers	primer	NNS
cord-310748-ao29zx1u	56	16	109	109	CD
cord-310748-ao29zx1u	56	17	and	and	CC
cord-310748-ao29zx1u	56	18	152	152	CD
cord-310748-ao29zx1u	56	19	.	.	.
cord-310748-ao29zx1u	57	1	Lane	lane	NN
cord-310748-ao29zx1u	57	2	5	5	CD
cord-310748-ao29zx1u	57	3	:	:	:
cord-310748-ao29zx1u	58	1	Equal	equal	JJ
cord-310748-ao29zx1u	58	2	amounts	amount	NNS
cord-310748-ao29zx1u	58	3	(	(	-LRB-
cord-310748-ao29zx1u	58	4	0.5	0.5	CD
cord-310748-ao29zx1u	58	5	ag	ag	NNP
cord-310748-ao29zx1u	58	6	)	)	-RRB-
cord-310748-ao29zx1u	58	7	of	of	IN
cord-310748-ao29zx1u	58	8	A59	A59	NNP
cord-310748-ao29zx1u	58	9	and	and	CC
cord-310748-ao29zx1u	58	10	JHM	JHM	NNP
cord-310748-ao29zx1u	58	11	-	-	HYPH
cord-310748-ao29zx1u	58	12	DL	DL	NNP
cord-310748-ao29zx1u	58	13	RNA	RNA	NNP
cord-310748-ao29zx1u	58	14	were	be	VBD
cord-310748-ao29zx1u	58	15	mixed	mix	VBN
cord-310748-ao29zx1u	58	16	together	together	RB
cord-310748-ao29zx1u	58	17	and	and	CC
cord-310748-ao29zx1u	58	18	amplified	amplify	VBN
cord-310748-ao29zx1u	58	19	by	by	IN
cord-310748-ao29zx1u	58	20	PCR	PCR	NNP
cord-310748-ao29zx1u	58	21	with	with	IN
cord-310748-ao29zx1u	58	22	primers	primer	NNS
cord-310748-ao29zx1u	58	23	109	109	CD
cord-310748-ao29zx1u	58	24	and	and	CC
cord-310748-ao29zx1u	58	25	152	152	CD
cord-310748-ao29zx1u	58	26	.	.	.
cord-310748-ao29zx1u	59	1	Lane	lane	NN
cord-310748-ao29zx1u	59	2	6	6	CD
cord-310748-ao29zx1u	59	3	:	:	:
cord-310748-ao29zx1u	60	1	Intracellular	Intracellular	NNP
cord-310748-ao29zx1u	60	2	RNA	RNA	NNP
cord-310748-ao29zx1u	60	3	from	from	IN
cord-310748-ao29zx1u	60	4	coinfected	coinfected	JJ
cord-310748-ao29zx1u	60	5	cells	cell	NNS
cord-310748-ao29zx1u	60	6	was	be	VBD
cord-310748-ao29zx1u	60	7	amplified	amplify	VBN
cord-310748-ao29zx1u	60	8	using	use	VBG
cord-310748-ao29zx1u	60	9	primers	primer	NNS
cord-310748-ao29zx1u	60	10	109	109	CD
cord-310748-ao29zx1u	60	11	and	and	CC
cord-310748-ao29zx1u	60	12	152	152	CD
cord-310748-ao29zx1u	60	13	.	.	.
cord-310748-ao29zx1u	61	1	The	the	DT
cord-310748-ao29zx1u	61	2	lower	low	JJR
cord-310748-ao29zx1u	61	3	800~nt	800~nt	CD
cord-310748-ao29zx1u	61	4	band	band	NN
cord-310748-ao29zx1u	61	5	was	be	VBD
cord-310748-ao29zx1u	61	6	caused	cause	VBN
cord-310748-ao29zx1u	61	7	by	by	IN
cord-310748-ao29zx1u	61	8	incorrect	incorrect	JJ
cord-310748-ao29zx1u	61	9	binding	binding	NN
cord-310748-ao29zx1u	61	10	of	of	IN
cord-310748-ao29zx1u	61	11	primer	primer	NN
cord-310748-ao29zx1u	61	12	109	109	CD
cord-310748-ao29zx1u	61	13	at	at	IN
cord-310748-ao29zx1u	61	14	nucleotide	nucleotide	JJ
cord-310748-ao29zx1u	61	15	140	140	CD
cord-310748-ao29zx1u	61	16	1	1	CD
cord-310748-ao29zx1u	61	17	of	of	IN
cord-310748-ao29zx1u	61	18	the	the	DT
cord-310748-ao29zx1u	61	19	S	S	NNP
cord-310748-ao29zx1u	61	20	gene	gene	NN
cord-310748-ao29zx1u	61	21	on	on	IN
cord-310748-ao29zx1u	61	22	the	the	DT
cord-310748-ao29zx1u	61	23	A59	A59	NNP
cord-310748-ao29zx1u	61	24	RNA	RNA	NNP
cord-310748-ao29zx1u	61	25	.	.	.
cord-310748-ao29zx1u	62	1	Lane	lane	NN
cord-310748-ao29zx1u	62	2	7	7	CD
cord-310748-ao29zx1u	62	3	:	:	:
cord-310748-ao29zx1u	63	1	Same	same	JJ
cord-310748-ao29zx1u	63	2	as	as	IN
cord-310748-ao29zx1u	63	3	lane	lane	NN
cord-310748-ao29zx1u	63	4	5	5	CD
cord-310748-ao29zx1u	63	5	,	,	,
cord-310748-ao29zx1u	63	6	except	except	IN
cord-310748-ao29zx1u	63	7	that	that	IN
cord-310748-ao29zx1u	63	8	the	the	DT
cord-310748-ao29zx1u	63	9	RNA	RNA	NNP
cord-310748-ao29zx1u	63	10	mixture	mixture	NN
cord-310748-ao29zx1u	63	11	was	be	VBD
cord-310748-ao29zx1u	63	12	from	from	IN
cord-310748-ao29zx1u	63	13	purified	purify	VBN
cord-310748-ao29zx1u	63	14	virions	virion	NNS
cord-310748-ao29zx1u	63	15	derived	derive	VBN
cord-310748-ao29zx1u	63	16	from	from	IN
cord-310748-ao29zx1u	63	17	single	single	JJ
cord-310748-ao29zx1u	63	18	infections	infection	NNS
cord-310748-ao29zx1u	63	19	.	.	.
cord-310748-ao29zx1u	64	1	Lane	lane	NN
cord-310748-ao29zx1u	64	2	8	8	CD
cord-310748-ao29zx1u	64	3	:	:	:
cord-310748-ao29zx1u	64	4	Same	same	JJ
cord-310748-ao29zx1u	64	5	as	as	IN
cord-310748-ao29zx1u	64	6	lane	lane	NN
cord-310748-ao29zx1u	64	7	6	6	CD
cord-310748-ao29zx1u	64	8	.	.	.
cord-310748-ao29zx1u	65	1	except	except	IN
cord-310748-ao29zx1u	65	2	that	that	DT
cord-310748-ao29zx1u	65	3	purified	purify	VBN
cord-310748-ao29zx1u	65	4	virion	virion	NN
cord-310748-ao29zx1u	65	5	RNA	RNA	NNP
cord-310748-ao29zx1u	65	6	released	release	VBN
cord-310748-ao29zx1u	65	7	from	from	IN
cord-310748-ao29zx1u	65	8	the	the	DT
cord-310748-ao29zx1u	65	9	coinfected	coinfected	JJ
cord-310748-ao29zx1u	65	10	cells	cell	NNS
cord-310748-ao29zx1u	65	11	was	be	VBD
cord-310748-ao29zx1u	65	12	used	use	VBN
cord-310748-ao29zx1u	65	13	.	.	.
cord-310748-ao29zx1u	66	1	cycle	cycle	NN
cord-310748-ao29zx1u	66	2	consisting	consist	VBG
cord-310748-ao29zx1u	66	3	of	of	IN
cord-310748-ao29zx1u	66	4	94	94	CD
cord-310748-ao29zx1u	66	5	"	"	''
cord-310748-ao29zx1u	66	6	for	for	IN
cord-310748-ao29zx1u	66	7	1'30	1'30	CD
cord-310748-ao29zx1u	66	8	"	"	''
cord-310748-ao29zx1u	66	9	,	,	,
cord-310748-ao29zx1u	66	10	58	58	CD
cord-310748-ao29zx1u	66	11	"	"	``
cord-310748-ao29zx1u	66	12	for	for	IN
cord-310748-ao29zx1u	66	13	2	2	CD
cord-310748-ao29zx1u	66	14	'	'	''
cord-310748-ao29zx1u	66	15	,	,	,
cord-310748-ao29zx1u	66	16	and	and	CC
cord-310748-ao29zx1u	66	17	72	72	CD
cord-310748-ao29zx1u	66	18	"	"	``
cord-310748-ao29zx1u	66	19	for	for	IN
cord-310748-ao29zx1u	66	20	3	3	CD
cord-310748-ao29zx1u	66	21	'	'	''
cord-310748-ao29zx1u	66	22	.	.	.
cord-310748-ao29zx1u	67	1	To	to	TO
cord-310748-ao29zx1u	67	2	confirm	confirm	VB
cord-310748-ao29zx1u	67	3	that	that	IN
cord-310748-ao29zx1u	67	4	the	the	DT
cord-310748-ao29zx1u	67	5	two	two	CD
cord-310748-ao29zx1u	67	6	primers	primer	NNS
cord-310748-ao29zx1u	67	7	were	be	VBD
cord-310748-ao29zx1u	67	8	specific	specific	JJ
cord-310748-ao29zx1u	67	9	for	for	IN
cord-310748-ao29zx1u	67	10	the	the	DT
cord-310748-ao29zx1u	67	11	recombinants	recombinant	NNS
cord-310748-ao29zx1u	67	12	,	,	,
cord-310748-ao29zx1u	67	13	each	each	DT
cord-310748-ao29zx1u	67	14	virus	virus	NN
cord-310748-ao29zx1u	67	15	was	be	VBD
cord-310748-ao29zx1u	67	16	grown	grow	VBN
cord-310748-ao29zx1u	67	17	separately	separately	RB
cord-310748-ao29zx1u	67	18	,	,	,
cord-310748-ao29zx1u	67	19	and	and	CC
cord-310748-ao29zx1u	67	20	the	the	DT
cord-310748-ao29zx1u	67	21	RNA	RNA	NNP
cord-310748-ao29zx1u	67	22	extracted	extract	VBD
cord-310748-ao29zx1u	67	23	and	and	CC
cord-310748-ao29zx1u	67	24	amplified	amplify	VBN
cord-310748-ao29zx1u	67	25	by	by	IN
cord-310748-ao29zx1u	67	26	PCR	PCR	NNP
cord-310748-ao29zx1u	67	27	using	use	VBG
cord-310748-ao29zx1u	67	28	the	the	DT
cord-310748-ao29zx1u	67	29	pair	pair	NN
cord-310748-ao29zx1u	67	30	of	of	IN
cord-310748-ao29zx1u	67	31	primers	primer	NNS
cord-310748-ao29zx1u	67	32	described	describe	VBN
cord-310748-ao29zx1u	67	33	.	.	.
cord-310748-ao29zx1u	68	1	No	no	DT
cord-310748-ao29zx1u	68	2	product	product	NN
cord-310748-ao29zx1u	68	3	of	of	IN
cord-310748-ao29zx1u	68	4	expected	expect	VBN
cord-310748-ao29zx1u	68	5	size	size	NN
cord-310748-ao29zx1u	68	6	(	(	-LRB-
cord-310748-ao29zx1u	68	7	950	950	CD
cord-310748-ao29zx1u	68	8	bp	bp	NNP
cord-310748-ao29zx1u	68	9	)	)	-RRB-
cord-310748-ao29zx1u	68	10	was	be	VBD
cord-310748-ao29zx1u	68	11	detected	detect	VBN
cord-310748-ao29zx1u	68	12	(	(	-LRB-
cord-310748-ao29zx1u	68	13	Fig	Fig	NNP
cord-310748-ao29zx1u	68	14	.	.	NNP
cord-310748-ao29zx1u	68	15	1	1	CD
cord-310748-ao29zx1u	68	16	,	,	,
cord-310748-ao29zx1u	68	17	lanes	lane	VBZ
cord-310748-ao29zx1u	68	18	3	3	CD
cord-310748-ao29zx1u	68	19	and	and	CC
cord-310748-ao29zx1u	68	20	4	4	CD
cord-310748-ao29zx1u	68	21	)	)	-RRB-
cord-310748-ao29zx1u	68	22	.	.	.
cord-310748-ao29zx1u	69	1	However	however	RB
cord-310748-ao29zx1u	69	2	,	,	,
cord-310748-ao29zx1u	69	3	when	when	WRB
cord-310748-ao29zx1u	69	4	RNA	RNA	NNP
cord-310748-ao29zx1u	69	5	from	from	IN
cord-310748-ao29zx1u	69	6	the	the	DT
cord-310748-ao29zx1u	69	7	coinfected	coinfected	JJ
cord-310748-ao29zx1u	69	8	cells	cell	NNS
cord-310748-ao29zx1u	69	9	was	be	VBD
cord-310748-ao29zx1u	69	10	used	use	VBN
cord-310748-ao29zx1u	69	11	,	,	,
cord-310748-ao29zx1u	69	12	a	a	DT
cord-310748-ao29zx1u	69	13	specific	specific	JJ
cord-310748-ao29zx1u	69	14	product	product	NN
cord-310748-ao29zx1u	69	15	of	of	IN
cord-310748-ao29zx1u	69	16	950	950	CD
cord-310748-ao29zx1u	69	17	bp	bp	NNP
cord-310748-ao29zx1u	69	18	(	(	-LRB-
cord-310748-ao29zx1u	69	19	Fig	Fig	NNP
cord-310748-ao29zx1u	69	20	.	.	NNP
cord-310748-ao29zx1u	69	21	1	1	CD
cord-310748-ao29zx1u	69	22	,	,	,
cord-310748-ao29zx1u	69	23	lane	lane	NN
cord-310748-ao29zx1u	69	24	6	6	CD
cord-310748-ao29zx1u	69	25	)	)	-RRB-
cord-310748-ao29zx1u	69	26	most	most	RBS
cord-310748-ao29zx1u	69	27	likely	likely	RB
cord-310748-ao29zx1u	69	28	derived	derive	VBN
cord-310748-ao29zx1u	69	29	from	from	IN
cord-310748-ao29zx1u	69	30	the	the	DT
cord-310748-ao29zx1u	69	31	recombinant	recombinant	JJ
cord-310748-ao29zx1u	69	32	RNA	RNA	NNP
cord-310748-ao29zx1u	69	33	,	,	,
cord-310748-ao29zx1u	69	34	was	be	VBD
cord-310748-ao29zx1u	69	35	detected	detect	VBN
cord-310748-ao29zx1u	69	36	.	.	.
cord-310748-ao29zx1u	70	1	Several	several	JJ
cord-310748-ao29zx1u	70	2	smaller	small	JJR
cord-310748-ao29zx1u	70	3	bands	band	NNS
cord-310748-ao29zx1u	70	4	were	be	VBD
cord-310748-ao29zx1u	70	5	observed	observe	VBN
cord-310748-ao29zx1u	70	6	,	,	,
cord-310748-ao29zx1u	70	7	but	but	CC
cord-310748-ao29zx1u	70	8	these	these	DT
cord-310748-ao29zx1u	70	9	represented	represent	VBD
cord-310748-ao29zx1u	70	10	nonspecific	nonspecific	JJ
cord-310748-ao29zx1u	70	11	PCR	PCR	NNP
cord-310748-ao29zx1u	70	12	products	product	NNS
cord-310748-ao29zx1u	70	13	since	since	IN
cord-310748-ao29zx1u	70	14	they	-PRON-	PRP
cord-310748-ao29zx1u	70	15	also	also	RB
cord-310748-ao29zx1u	70	16	were	be	VBD
cord-310748-ao29zx1u	70	17	seen	see	VBN
cord-310748-ao29zx1u	70	18	in	in	IN
cord-310748-ao29zx1u	70	19	control	control	NN
cord-310748-ao29zx1u	70	20	lanes	lane	NNS
cord-310748-ao29zx1u	70	21	.	.	.
cord-310748-ao29zx1u	71	1	The	the	DT
cord-310748-ao29zx1u	71	2	presence	presence	NN
cord-310748-ao29zx1u	71	3	of	of	IN
cord-310748-ao29zx1u	71	4	each	each	DT
cord-310748-ao29zx1u	71	5	parental	parental	JJ
cord-310748-ao29zx1u	71	6	RNA	RNA	NNP
cord-310748-ao29zx1u	71	7	in	in	IN
cord-310748-ao29zx1u	71	8	the	the	DT
cord-310748-ao29zx1u	71	9	coinfected	coinfected	JJ
cord-310748-ao29zx1u	71	10	cells	cell	NNS
cord-310748-ao29zx1u	71	11	was	be	VBD
cord-310748-ao29zx1u	71	12	confirmed	confirm	VBN
cord-310748-ao29zx1u	71	13	by	by	IN
cord-310748-ao29zx1u	71	14	using	use	VBG
cord-310748-ao29zx1u	71	15	different	different	JJ
cord-310748-ao29zx1u	71	16	primer	primer	NN
cord-310748-ao29zx1u	71	17	pairs	pair	NNS
cord-310748-ao29zx1u	71	18	specific	specific	JJ
cord-310748-ao29zx1u	71	19	for	for	IN
cord-310748-ao29zx1u	71	20	each	each	DT
cord-310748-ao29zx1u	71	21	parent	parent	NN
cord-310748-ao29zx1u	71	22	(	(	-LRB-
cord-310748-ao29zx1u	71	23	Fig	Fig	NNP
cord-310748-ao29zx1u	71	24	.	.	NNP
cord-310748-ao29zx1u	71	25	1	1	CD
cord-310748-ao29zx1u	71	26	,	,	,
cord-310748-ao29zx1u	71	27	 	 	_SP
cord-310748-ao29zx1u	71	28	lanes	lane	NNS
cord-310748-ao29zx1u	71	29	1	1	CD
cord-310748-ao29zx1u	71	30	and	and	CC
cord-310748-ao29zx1u	71	31	2	2	CD
cord-310748-ao29zx1u	71	32	)	)	-RRB-
cord-310748-ao29zx1u	71	33	.	.	.
cord-310748-ao29zx1u	72	1	To	to	TO
cord-310748-ao29zx1u	72	2	rule	rule	VB
cord-310748-ao29zx1u	72	3	out	out	RP
cord-310748-ao29zx1u	72	4	the	the	DT
cord-310748-ao29zx1u	72	5	possibility	possibility	NN
cord-310748-ao29zx1u	72	6	that	that	IN
cord-310748-ao29zx1u	72	7	this	this	DT
cord-310748-ao29zx1u	72	8	PCR	PCR	NNP
cord-310748-ao29zx1u	72	9	product	product	NN
cord-310748-ao29zx1u	72	10	was	be	VBD
cord-310748-ao29zx1u	72	11	generated	generate	VBN
cord-310748-ao29zx1u	72	12	by	by	IN
cord-310748-ao29zx1u	72	13	transcriptional	transcriptional	JJ
cord-310748-ao29zx1u	72	14	jumping	jumping	NN
cord-310748-ao29zx1u	72	15	of	of	IN
cord-310748-ao29zx1u	72	16	reverse	reverse	JJ
cord-310748-ao29zx1u	72	17	transcriptase	transcriptase	NN
cord-310748-ao29zx1u	72	18	or	or	CC
cord-310748-ao29zx1u	72	19	Taq	taq	NN
cord-310748-ao29zx1u	72	20	polymerase	polymerase	NN
cord-310748-ao29zx1u	72	21	,	,	,
cord-310748-ao29zx1u	72	22	RNA	RNA	NNP
cord-310748-ao29zx1u	72	23	from	from	IN
cord-310748-ao29zx1u	72	24	separate	separate	JJ
cord-310748-ao29zx1u	72	25	A59	A59	NNP
cord-310748-ao29zx1u	72	26	and	and	CC
cord-310748-ao29zx1u	72	27	JHM	JHM	NNP
cord-310748-ao29zx1u	72	28	-	-	HYPH
cord-310748-ao29zx1u	72	29	DL	DL	NNP
cord-310748-ao29zx1u	72	30	infections	infection	NNS
cord-310748-ao29zx1u	72	31	was	be	VBD
cord-310748-ao29zx1u	72	32	mixed	mix	VBN
cord-310748-ao29zx1u	72	33	to	to	IN
cord-310748-ao29zx1u	72	34	-	-	HYPH
cord-310748-ao29zx1u	72	35	gether	gether	XX
cord-310748-ao29zx1u	72	36	in	in	IN
cord-310748-ao29zx1u	72	37	equal	equal	JJ
cord-310748-ao29zx1u	72	38	amounts	amount	NNS
cord-310748-ao29zx1u	72	39	such	such	JJ
cord-310748-ao29zx1u	72	40	that	that	IN
cord-310748-ao29zx1u	72	41	the	the	DT
cord-310748-ao29zx1u	72	42	total	total	JJ
cord-310748-ao29zx1u	72	43	amount	amount	NN
cord-310748-ao29zx1u	72	44	equaled	equal	VBD
cord-310748-ao29zx1u	72	45	that	that	DT
cord-310748-ao29zx1u	72	46	of	of	IN
cord-310748-ao29zx1u	72	47	the	the	DT
cord-310748-ao29zx1u	72	48	RNA	RNA	NNP
cord-310748-ao29zx1u	72	49	from	from	IN
cord-310748-ao29zx1u	72	50	the	the	DT
cord-310748-ao29zx1u	72	51	coinfection	coinfection	NN
cord-310748-ao29zx1u	72	52	.	.	.
cord-310748-ao29zx1u	73	1	When	when	WRB
cord-310748-ao29zx1u	73	2	the	the	DT
cord-310748-ao29zx1u	73	3	RNA	RNA	NNP
cord-310748-ao29zx1u	73	4	mixture	mixture	NN
cord-310748-ao29zx1u	73	5	was	be	VBD
cord-310748-ao29zx1u	73	6	used	use	VBN
cord-310748-ao29zx1u	73	7	as	as	IN
cord-310748-ao29zx1u	73	8	a	a	DT
cord-310748-ao29zx1u	73	9	template	template	NN
cord-310748-ao29zx1u	73	10	for	for	IN
cord-310748-ao29zx1u	73	11	reverse	reverse	JJ
cord-310748-ao29zx1u	73	12	transcription	transcription	NN
cord-310748-ao29zx1u	73	13	and	and	CC
cord-310748-ao29zx1u	73	14	PCR	PCR	NNP
cord-310748-ao29zx1u	73	15	,	,	,
cord-310748-ao29zx1u	73	16	the	the	DT
cord-310748-ao29zx1u	73	17	specific	specific	JJ
cord-310748-ao29zx1u	73	18	950-bp	950-bp	CD
cord-310748-ao29zx1u	73	19	product	product	NN
cord-310748-ao29zx1u	73	20	was	be	VBD
cord-310748-ao29zx1u	73	21	not	not	RB
cord-310748-ao29zx1u	73	22	detected	detect	VBN
cord-310748-ao29zx1u	74	1	(	(	-LRB-
cord-310748-ao29zx1u	74	2	Fig	Fig	NNP
cord-310748-ao29zx1u	74	3	.	.	NNP
cord-310748-ao29zx1u	74	4	1	1	CD
cord-310748-ao29zx1u	74	5	,	,	,
cord-310748-ao29zx1u	74	6	lane	lane	NN
cord-310748-ao29zx1u	74	7	5	5	CD
cord-310748-ao29zx1u	74	8	)	)	-RRB-
cord-310748-ao29zx1u	74	9	.	.	.
cord-310748-ao29zx1u	75	1	Thus	thus	RB
cord-310748-ao29zx1u	75	2	,	,	,
cord-310748-ao29zx1u	75	3	the	the	DT
cord-310748-ao29zx1u	75	4	PCR	PCR	NNP
cord-310748-ao29zx1u	75	5	product	product	NN
cord-310748-ao29zx1u	75	6	present	present	JJ
cord-310748-ao29zx1u	75	7	in	in	IN
cord-310748-ao29zx1u	75	8	lane	lane	NN
cord-310748-ao29zx1u	75	9	6	6	CD
cord-310748-ao29zx1u	76	1	(	(	-LRB-
cord-310748-ao29zx1u	76	2	Fig	Fig	NNP
cord-310748-ao29zx1u	76	3	.	.	NNP
cord-310748-ao29zx1u	76	4	1	1	CD
cord-310748-ao29zx1u	76	5	)	)	-RRB-
cord-310748-ao29zx1u	76	6	resulted	result	VBD
cord-310748-ao29zx1u	76	7	from	from	IN
cord-310748-ao29zx1u	76	8	recombination	recombination	NN
cord-310748-ao29zx1u	76	9	events	event	NNS
cord-310748-ao29zx1u	76	10	which	which	WDT
cord-310748-ao29zx1u	76	11	occurred	occur	VBD
cord-310748-ao29zx1u	76	12	during	during	IN
cord-310748-ao29zx1u	76	13	the	the	DT
cord-310748-ao29zx1u	76	14	coinfection	coinfection	NN
cord-310748-ao29zx1u	76	15	.	.	.
cord-310748-ao29zx1u	77	1	To	to	TO
cord-310748-ao29zx1u	77	2	examine	examine	VB
cord-310748-ao29zx1u	77	3	the	the	DT
cord-310748-ao29zx1u	77	4	possible	possible	JJ
cord-310748-ao29zx1u	77	5	sites	site	NNS
cord-310748-ao29zx1u	77	6	of	of	IN
cord-310748-ao29zx1u	77	7	recombination	recombination	NN
cord-310748-ao29zx1u	77	8	,	,	,
cord-310748-ao29zx1u	77	9	the	the	DT
cord-310748-ao29zx1u	77	10	PCR	PCR	NNP
cord-310748-ao29zx1u	77	11	product	product	NN
cord-310748-ao29zx1u	77	12	was	be	VBD
cord-310748-ao29zx1u	77	13	purified	purify	VBN
cord-310748-ao29zx1u	77	14	from	from	IN
cord-310748-ao29zx1u	77	15	low	low	JJ
cord-310748-ao29zx1u	77	16	-	-	HYPH
cord-310748-ao29zx1u	77	17	melt	melt	NN
cord-310748-ao29zx1u	77	18	agarose	agarose	NN
cord-310748-ao29zx1u	77	19	and	and	CC
cord-310748-ao29zx1u	77	20	directionally	directionally	RB
cord-310748-ao29zx1u	77	21	cloned	clone	VBN
cord-310748-ao29zx1u	77	22	into	into	IN
cord-310748-ao29zx1u	77	23	the	the	DT
cord-310748-ao29zx1u	77	24	vector	vector	NN
cord-310748-ao29zx1u	77	25	pTZ18U	ptz18u	JJ
cord-310748-ao29zx1u	77	26	(	(	-LRB-
cord-310748-ao29zx1u	77	27	U.S.	U.S.	NNP
cord-310748-ao29zx1u	77	28	Biochemicals	Biochemicals	NNPS
cord-310748-ao29zx1u	77	29	,	,	,
cord-310748-ao29zx1u	77	30	Cleveland	Cleveland	NNP
cord-310748-ao29zx1u	77	31	,	,	,
cord-310748-ao29zx1u	77	32	OH	OH	NNP
cord-310748-ao29zx1u	77	33	)	)	-RRB-
cord-310748-ao29zx1u	77	34	through	through	IN
cord-310748-ao29zx1u	77	35	a	a	DT
cord-310748-ao29zx1u	77	36	Sac1	Sac1	NNP
cord-310748-ao29zx1u	77	37	restriction	restriction	NN
cord-310748-ao29zx1u	77	38	site	site	NN
cord-310748-ao29zx1u	77	39	present	present	JJ
cord-310748-ao29zx1u	77	40	on	on	IN
cord-310748-ao29zx1u	77	41	the	the	DT
cord-310748-ao29zx1u	77	42	5'-end	5'-end	CD
cord-310748-ao29zx1u	77	43	primer	primer	NN
cord-310748-ao29zx1u	77	44	and	and	CC
cord-310748-ao29zx1u	77	45	Smal	Smal	NNP
cord-310748-ao29zx1u	77	46	on	on	IN
cord-310748-ao29zx1u	77	47	the	the	DT
cord-310748-ao29zx1u	77	48	3'-side	3'-side	NN
cord-310748-ao29zx1u	77	49	.	.	.
cord-310748-ao29zx1u	78	1	DNA	dna	NN
cord-310748-ao29zx1u	78	2	sequence	sequence	NN
cord-310748-ao29zx1u	78	3	analysis	analysis	NN
cord-310748-ao29zx1u	78	4	of	of	IN
cord-310748-ao29zx1u	78	5	35	35	CD
cord-310748-ao29zx1u	78	6	cloned	clone	VBN
cord-310748-ao29zx1u	78	7	PCR	PCR	NNP
cord-310748-ao29zx1u	78	8	products	product	NNS
cord-310748-ao29zx1u	78	9	showed	show	VBD
cord-310748-ao29zx1u	78	10	that	that	IN
cord-310748-ao29zx1u	78	11	the	the	DT
cord-310748-ao29zx1u	78	12	crossover	crossover	NN
cord-310748-ao29zx1u	78	13	sites	site	NNS
cord-310748-ao29zx1u	78	14	were	be	VBD
cord-310748-ao29zx1u	78	15	almost	almost	RB
cord-310748-ao29zx1u	78	16	randomly	randomly	RB
cord-310748-ao29zx1u	78	17	distributed	distribute	VBN
cord-310748-ao29zx1u	78	18	throughout	throughout	IN
cord-310748-ao29zx1u	78	19	the	the	DT
cord-310748-ao29zx1u	78	20	nearly	nearly	RB
cord-310748-ao29zx1u	78	21	1-kb	1-kb	CD
cord-310748-ao29zx1u	78	22	region	region	NN
cord-310748-ao29zx1u	78	23	of	of	IN
cord-310748-ao29zx1u	78	24	the	the	DT
cord-310748-ao29zx1u	78	25	peplomer	peplomer	NNP
cord-310748-ao29zx1u	78	26	gene	gene	NN
cord-310748-ao29zx1u	78	27	studied	study	VBD
cord-310748-ao29zx1u	78	28	(	(	-LRB-
cord-310748-ao29zx1u	78	29	Fig	Fig	NNP
cord-310748-ao29zx1u	78	30	.	.	.
cord-310748-ao29zx1u	78	31	2A	2a	CD
cord-310748-ao29zx1u	78	32	)	)	-RRB-
cord-310748-ao29zx1u	78	33	.	.	.
cord-310748-ao29zx1u	79	1	Two	two	CD
cord-310748-ao29zx1u	79	2	additional	additional	JJ
cord-310748-ao29zx1u	79	3	recombinants	recombinant	NNS
cord-310748-ao29zx1u	79	4	had	have	VBD
cord-310748-ao29zx1u	79	5	triple	triple	JJ
cord-310748-ao29zx1u	79	6	crossovers	crossover	NNS
cord-310748-ao29zx1u	79	7	;	;	:
cord-310748-ao29zx1u	79	8	one	one	PRP
cord-310748-ao29zx1u	79	9	had	have	VBD
cord-310748-ao29zx1u	79	10	three	three	CD
cord-310748-ao29zx1u	79	11	crossovers	crossover	NNS
cord-310748-ao29zx1u	79	12	which	which	WDT
cord-310748-ao29zx1u	79	13	occurred	occur	VBD
cord-310748-ao29zx1u	79	14	within	within	IN
cord-310748-ao29zx1u	79	15	a	a	DT
cord-310748-ao29zx1u	79	16	span	span	NN
cord-310748-ao29zx1u	79	17	of	of	IN
cord-310748-ao29zx1u	79	18	98	98	CD
cord-310748-ao29zx1u	79	19	nt	nt	NN
cord-310748-ao29zx1u	79	20	(	(	-LRB-
cord-310748-ao29zx1u	79	21	from	from	IN
cord-310748-ao29zx1u	79	22	986	986	CD
cord-310748-ao29zx1u	79	23	to	to	IN
cord-310748-ao29zx1u	79	24	1084	1084	CD
cord-310748-ao29zx1u	79	25	)	)	-RRB-
cord-310748-ao29zx1u	79	26	and	and	CC
cord-310748-ao29zx1u	79	27	the	the	DT
cord-310748-ao29zx1u	79	28	other	other	JJ
cord-310748-ao29zx1u	79	29	within	within	IN
cord-310748-ao29zx1u	79	30	249	249	CD
cord-310748-ao29zx1u	79	31	nt	nt	NN
cord-310748-ao29zx1u	79	32	(	(	-LRB-
cord-310748-ao29zx1u	79	33	from	from	IN
cord-310748-ao29zx1u	79	34	897	897	CD
cord-310748-ao29zx1u	79	35	to	to	IN
cord-310748-ao29zx1u	79	36	1146	1146	CD
cord-310748-ao29zx1u	79	37	)	)	-RRB-
cord-310748-ao29zx1u	79	38	.	.	.
cord-310748-ao29zx1u	80	1	One	one	CD
cord-310748-ao29zx1u	80	2	recombinant	recombinant	JJ
cord-310748-ao29zx1u	80	3	RNA	RNA	NNP
cord-310748-ao29zx1u	80	4	had	have	VBD
cord-310748-ao29zx1u	80	5	a	a	DT
cord-310748-ao29zx1u	80	6	30-nt	30-nt	CD
cord-310748-ao29zx1u	80	7	deletion	deletion	NN
cord-310748-ao29zx1u	80	8	,	,	,
cord-310748-ao29zx1u	80	9	with	with	IN
cord-310748-ao29zx1u	80	10	each	each	DT
cord-310748-ao29zx1u	80	11	parental	parental	JJ
cord-310748-ao29zx1u	80	12	sequence	sequence	NN
cord-310748-ao29zx1u	80	13	flanking	flank	VBG
cord-310748-ao29zx1u	80	14	the	the	DT
cord-310748-ao29zx1u	80	15	deletion	deletion	NN
cord-310748-ao29zx1u	80	16	(	(	-LRB-
cord-310748-ao29zx1u	80	17	Fig	Fig	NNP
cord-310748-ao29zx1u	80	18	.	.	.
cord-310748-ao29zx1u	80	19	3	3	CD
cord-310748-ao29zx1u	80	20	)	)	-RRB-
cord-310748-ao29zx1u	80	21	.	.	.
cord-310748-ao29zx1u	81	1	It	-PRON-	PRP
cord-310748-ao29zx1u	81	2	is	be	VBZ
cord-310748-ao29zx1u	81	3	noteworthy	noteworthy	JJ
cord-310748-ao29zx1u	81	4	that	that	IN
cord-310748-ao29zx1u	81	5	the	the	DT
cord-310748-ao29zx1u	81	6	deleted	delete	VBN
cord-310748-ao29zx1u	81	7	site	site	NN
cord-310748-ao29zx1u	81	8	was	be	VBD
cord-310748-ao29zx1u	81	9	flanked	flank	VBN
cord-310748-ao29zx1u	81	10	by	by	IN
cord-310748-ao29zx1u	81	11	a	a	DT
cord-310748-ao29zx1u	81	12	6-nt	6-nt	CD
cord-310748-ao29zx1u	81	13	repeat	repeat	NN
cord-310748-ao29zx1u	81	14	,	,	,
cord-310748-ao29zx1u	81	15	but	but	CC
cord-310748-ao29zx1u	81	16	only	only	RB
cord-310748-ao29zx1u	81	17	one	one	CD
cord-310748-ao29zx1u	81	18	copy	copy	NN
cord-310748-ao29zx1u	81	19	of	of	IN
cord-310748-ao29zx1u	81	20	the	the	DT
cord-310748-ao29zx1u	81	21	repeat	repeat	NN
cord-310748-ao29zx1u	81	22	was	be	VBD
cord-310748-ao29zx1u	81	23	retained	retain	VBN
cord-310748-ao29zx1u	81	24	in	in	IN
cord-310748-ao29zx1u	81	25	the	the	DT
cord-310748-ao29zx1u	81	26	recombinant	recombinant	NN
cord-310748-ao29zx1u	81	27	.	.	.
cord-310748-ao29zx1u	82	1	The	the	DT
cord-310748-ao29zx1u	82	2	structure	structure	NN
cord-310748-ao29zx1u	82	3	of	of	IN
cord-310748-ao29zx1u	82	4	this	this	DT
cord-310748-ao29zx1u	82	5	recombinant	recombinant	NN
cord-310748-ao29zx1u	82	6	was	be	VBD
cord-310748-ao29zx1u	82	7	consistent	consistent	JJ
cord-310748-ao29zx1u	82	8	with	with	IN
cord-310748-ao29zx1u	82	9	the	the	DT
cord-310748-ao29zx1u	82	10	interpretation	interpretation	NN
cord-310748-ao29zx1u	82	11	that	that	WDT
cord-310748-ao29zx1u	82	12	RNA	RNA	NNP
cord-310748-ao29zx1u	82	13	recombination	recombination	NN
cord-310748-ao29zx1u	82	14	occurs	occur	VBZ
cord-310748-ao29zx1u	82	15	by	by	IN
cord-310748-ao29zx1u	82	16	a	a	DT
cord-310748-ao29zx1u	82	17	copy	copy	NN
cord-310748-ao29zx1u	82	18	-	-	HYPH
cord-310748-ao29zx1u	82	19	choice	choice	NN
cord-310748-ao29zx1u	82	20	mechanism	mechanism	NN
cord-310748-ao29zx1u	82	21	as	as	IN
cord-310748-ao29zx1u	82	22	a	a	DT
cord-310748-ao29zx1u	82	23	result	result	NN
cord-310748-ao29zx1u	82	24	of	of	IN
cord-310748-ao29zx1u	82	25	polymerase	polymerase	NN
cord-310748-ao29zx1u	82	26	jumping	jump	VBG
cord-310748-ao29zx1u	82	27	during	during	IN
cord-310748-ao29zx1u	82	28	transcription	transcription	NN
cord-310748-ao29zx1u	82	29	.	.	.
cord-310748-ao29zx1u	83	1	We	-PRON-	PRP
cord-310748-ao29zx1u	83	2	next	next	RB
cord-310748-ao29zx1u	83	3	sought	seek	VBD
cord-310748-ao29zx1u	83	4	to	to	TO
cord-310748-ao29zx1u	83	5	determine	determine	VB
cord-310748-ao29zx1u	83	6	whether	whether	IN
cord-310748-ao29zx1u	83	7	there	there	EX
cord-310748-ao29zx1u	83	8	were	be	VBD
cord-310748-ao29zx1u	83	9	any	any	DT
cord-310748-ao29zx1u	83	10	selection	selection	NN
cord-310748-ao29zx1u	83	11	advantages	advantage	NNS
cord-310748-ao29zx1u	83	12	or	or	CC
cord-310748-ao29zx1u	83	13	disadvantages	disadvantage	NNS
cord-310748-ao29zx1u	83	14	for	for	IN
cord-310748-ao29zx1u	83	15	certain	certain	JJ
cord-310748-ao29zx1u	83	16	recombination	recombination	NN
cord-310748-ao29zx1u	83	17	sites	site	NNS
cord-310748-ao29zx1u	83	18	once	once	IN
cord-310748-ao29zx1u	83	19	the	the	DT
cord-310748-ao29zx1u	83	20	RNA	RNA	NNP
cord-310748-ao29zx1u	83	21	was	be	VBD
cord-310748-ao29zx1u	83	22	packaged	package	VBN
cord-310748-ao29zx1u	83	23	into	into	IN
cord-310748-ao29zx1u	83	24	the	the	DT
cord-310748-ao29zx1u	83	25	virion	virion	NN
cord-310748-ao29zx1u	83	26	.	.	.
cord-310748-ao29zx1u	84	1	Cells	cell	NNS
cord-310748-ao29zx1u	84	2	were	be	VBD
cord-310748-ao29zx1u	84	3	coinfected	coinfecte	VBN
cord-310748-ao29zx1u	84	4	again	again	RB
cord-310748-ao29zx1u	84	5	with	with	IN
cord-310748-ao29zx1u	84	6	the	the	DT
cord-310748-ao29zx1u	84	7	same	same	JJ
cord-310748-ao29zx1u	84	8	virus	virus	NN
cord-310748-ao29zx1u	84	9	strains	strain	NNS
cord-310748-ao29zx1u	84	10	used	use	VBN
cord-310748-ao29zx1u	84	11	above	above	RB
cord-310748-ao29zx1u	84	12	.	.	.
cord-310748-ao29zx1u	85	1	After	after	IN
cord-310748-ao29zx1u	85	2	incubation	incubation	NN
cord-310748-ao29zx1u	85	3	for	for	IN
cord-310748-ao29zx1u	85	4	13	13	CD
cord-310748-ao29zx1u	85	5	hr	hr	NN
cord-310748-ao29zx1u	85	6	,	,	,
cord-310748-ao29zx1u	85	7	the	the	DT
cord-310748-ao29zx1u	85	8	medium	medium	NN
cord-310748-ao29zx1u	85	9	containing	contain	VBG
cord-310748-ao29zx1u	85	10	released	release	VBN
cord-310748-ao29zx1u	85	11	virus	virus	NN
cord-310748-ao29zx1u	85	12	particles	particle	NNS
cord-310748-ao29zx1u	85	13	was	be	VBD
cord-310748-ao29zx1u	85	14	harvested	harvest	VBN
cord-310748-ao29zx1u	85	15	and	and	CC
cord-310748-ao29zx1u	85	16	the	the	DT
cord-310748-ao29zx1u	85	17	virions	virion	NNS
cord-310748-ao29zx1u	85	18	were	be	VBD
cord-310748-ao29zx1u	85	19	pelleted	pellete	VBN
cord-310748-ao29zx1u	85	20	through	through	IN
cord-310748-ao29zx1u	85	21	a	a	DT
cord-310748-ao29zx1u	85	22	30	30	CD
cord-310748-ao29zx1u	85	23	%	%	NN
cord-310748-ao29zx1u	85	24	sucrose	sucrose	NN
cord-310748-ao29zx1u	85	25	cushion	cushion	NN
cord-310748-ao29zx1u	85	26	at	at	IN
cord-310748-ao29zx1u	85	27	26	26	CD
cord-310748-ao29zx1u	85	28	K	k	NN
cord-310748-ao29zx1u	85	29	in	in	IN
cord-310748-ao29zx1u	85	30	a	a	DT
cord-310748-ao29zx1u	85	31	Beckman	Beckman	NNP
cord-310748-ao29zx1u	85	32	SW	SW	NNP
cord-310748-ao29zx1u	85	33	28	28	CD
cord-310748-ao29zx1u	85	34	rotor	rotor	NN
cord-310748-ao29zx1u	85	35	for	for	IN
cord-310748-ao29zx1u	85	36	3.5	3.5	CD
cord-310748-ao29zx1u	85	37	hr	hr	NN
cord-310748-ao29zx1u	85	38	.	.	.
cord-310748-ao29zx1u	86	1	Viral	viral	JJ
cord-310748-ao29zx1u	86	2	genomic	genomic	NN
cord-310748-ao29zx1u	86	3	RNA	rna	NN
cord-310748-ao29zx1u	86	4	isolated	isolate	VBN
cord-310748-ao29zx1u	86	5	by	by	IN
cord-310748-ao29zx1u	86	6	proteinase	proteinase	NN
cord-310748-ao29zx1u	86	7	K	k	NN
cord-310748-ao29zx1u	86	8	treatment	treatment	NN
cord-310748-ao29zx1u	86	9	and	and	CC
cord-310748-ao29zx1u	86	10	phenol	phenol	NN
cord-310748-ao29zx1u	86	11	/	/	SYM
cord-310748-ao29zx1u	86	12	chloroform	chloroform	NN
cord-310748-ao29zx1u	86	13	extraction	extraction	NN
cord-310748-ao29zx1u	86	14	was	be	VBD
cord-310748-ao29zx1u	86	15	used	use	VBN
cord-310748-ao29zx1u	86	16	as	as	IN
cord-310748-ao29zx1u	86	17	a	a	DT
cord-310748-ao29zx1u	86	18	template	template	NN
cord-310748-ao29zx1u	86	19	for	for	IN
cord-310748-ao29zx1u	86	20	PCR	PCR	NNP
cord-310748-ao29zx1u	86	21	using	use	VBG
cord-310748-ao29zx1u	86	22	the	the	DT
cord-310748-ao29zx1u	86	23	same	same	JJ
cord-310748-ao29zx1u	86	24	primers	primer	NNS
cord-310748-ao29zx1u	86	25	described	describe	VBN
cord-310748-ao29zx1u	86	26	above	above	RB
cord-310748-ao29zx1u	86	27	.	.	.
cord-310748-ao29zx1u	87	1	Upon	upon	IN
cord-310748-ao29zx1u	87	2	applying	apply	VBG
cord-310748-ao29zx1u	87	3	the	the	DT
cord-310748-ao29zx1u	87	4	same	same	JJ
cord-310748-ao29zx1u	87	5	controls	control	NNS
cord-310748-ao29zx1u	87	6	as	as	IN
cord-310748-ao29zx1u	87	7	before	before	RB
cord-310748-ao29zx1u	87	8	,	,	,
cord-310748-ao29zx1u	87	9	the	the	DT
cord-310748-ao29zx1u	87	10	950-bp	950-bp	CD
cord-310748-ao29zx1u	87	11	recombinant	recombinant	JJ
cord-310748-ao29zx1u	87	12	product	product	NN
cord-310748-ao29zx1u	87	13	was	be	VBD
cord-310748-ao29zx1u	87	14	generated	generate	VBN
cord-310748-ao29zx1u	87	15	only	only	RB
cord-310748-ao29zx1u	87	16	from	from	IN
cord-310748-ao29zx1u	87	17	the	the	DT
cord-310748-ao29zx1u	87	18	viral	viral	JJ
cord-310748-ao29zx1u	87	19	RNA	RNA	NNP
cord-310748-ao29zx1u	87	20	derived	derive	VBN
cord-310748-ao29zx1u	87	21	from	from	IN
cord-310748-ao29zx1u	87	22	coinfection	coinfection	NN
cord-310748-ao29zx1u	87	23	(	(	-LRB-
cord-310748-ao29zx1u	87	24	Fig	Fig	NNP
cord-310748-ao29zx1u	87	25	.	.	NNP
cord-310748-ao29zx1u	87	26	1	1	CD
cord-310748-ao29zx1u	87	27	,	,	,
cord-310748-ao29zx1u	87	28	lane	lane	NN
cord-310748-ao29zx1u	87	29	8)	8)	NNP
cord-310748-ao29zx1u	87	30	.	.	.
cord-310748-ao29zx1u	88	1	The	the	DT
cord-310748-ao29zx1u	88	2	recombinant	recombinant	JJ
cord-310748-ao29zx1u	88	3	PCR	pcr	NN
cord-310748-ao29zx1u	88	4	product	product	NN
cord-310748-ao29zx1u	88	5	was	be	VBD
cord-310748-ao29zx1u	88	6	cloned	clone	VBN
cord-310748-ao29zx1u	88	7	into	into	IN
cord-310748-ao29zx1u	88	8	pliI18U	plii18u	NN
cord-310748-ao29zx1u	88	9	and	and	CC
cord-310748-ao29zx1u	88	10	DNA	dna	NN
cord-310748-ao29zx1u	88	11	from	from	IN
cord-310748-ao29zx1u	88	12	individual	individual	JJ
cord-310748-ao29zx1u	88	13	clones	clone	NNS
cord-310748-ao29zx1u	88	14	was	be	VBD
cord-310748-ao29zx1u	88	15	sequenced	sequence	VBN
cord-310748-ao29zx1u	88	16	.	.	.
cord-310748-ao29zx1u	89	1	Analysis	analysis	NN
cord-310748-ao29zx1u	89	2	of	of	IN
cord-310748-ao29zx1u	89	3	53	53	CD
cord-310748-ao29zx1u	89	4	recombinant	recombinant	JJ
cord-310748-ao29zx1u	89	5	clones	clone	NNS
cord-310748-ao29zx1u	89	6	revealed	reveal	VBD
cord-310748-ao29zx1u	89	7	that	that	IN
cord-310748-ao29zx1u	89	8	,	,	,
cord-310748-ao29zx1u	89	9	similar	similar	JJ
cord-310748-ao29zx1u	89	10	to	to	IN
cord-310748-ao29zx1u	89	11	the	the	DT
cord-310748-ao29zx1u	89	12	intracellular	intracellular	JJ
cord-310748-ao29zx1u	89	13	recombinants	recombinant	NNS
cord-310748-ao29zx1u	89	14	,	,	,
cord-310748-ao29zx1u	89	15	the	the	DT
cord-310748-ao29zx1u	89	16	crossover	crossover	NN
cord-310748-ao29zx1u	89	17	sites	site	NNS
cord-310748-ao29zx1u	89	18	in	in	IN
cord-310748-ao29zx1u	89	19	the	the	DT
cord-310748-ao29zx1u	89	20	viral	viral	JJ
cord-310748-ao29zx1u	89	21	recombinant	recombinant	JJ
cord-310748-ao29zx1u	89	22	RNAs	rna	NNS
cord-310748-ao29zx1u	89	23	were	be	VBD
cord-310748-ao29zx1u	89	24	almost	almost	RB
cord-310748-ao29zx1u	89	25	randomly	randomly	RB
cord-310748-ao29zx1u	89	26	distributed	distribute	VBN
cord-310748-ao29zx1u	89	27	over	over	IN
cord-310748-ao29zx1u	89	28	the	the	DT
cord-310748-ao29zx1u	89	29	1	1	CD
cord-310748-ao29zx1u	89	30	-kb	-kb	NNPS
cord-310748-ao29zx1u	89	31	region	region	NN
cord-310748-ao29zx1u	89	32	of	of	IN
cord-310748-ao29zx1u	89	33	the	the	DT
cord-310748-ao29zx1u	89	34	peplomer	peplomer	NNP
cord-310748-ao29zx1u	89	35	gene	gene	NN
cord-310748-ao29zx1u	89	36	(	(	-LRB-
cord-310748-ao29zx1u	89	37	Fig	Fig	NNP
cord-310748-ao29zx1u	89	38	.	.	.
cord-310748-ao29zx1u	89	39	2B	2b	CD
cord-310748-ao29zx1u	89	40	)	)	-RRB-
cord-310748-ao29zx1u	89	41	.	.	.
cord-310748-ao29zx1u	90	1	No	no	DT
cord-310748-ao29zx1u	90	2	triple	triple	JJ
cord-310748-ao29zx1u	90	3	crossovers	crossover	NNS
cord-310748-ao29zx1u	90	4	or	or	CC
cord-310748-ao29zx1u	90	5	deletions	deletion	NNS
cord-310748-ao29zx1u	90	6	were	be	VBD
cord-310748-ao29zx1u	90	7	detected	detect	VBN
cord-310748-ao29zx1u	90	8	.	.	.
cord-310748-ao29zx1u	91	1	We	-PRON-	PRP
cord-310748-ao29zx1u	91	2	then	then	RB
cord-310748-ao29zx1u	91	3	determined	determine	VBD
cord-310748-ao29zx1u	91	4	whether	whether	IN
cord-310748-ao29zx1u	91	5	the	the	DT
cord-310748-ao29zx1u	91	6	recombinant	recombinant	JJ
cord-310748-ao29zx1u	91	7	RNA	RNA	NNP
cord-310748-ao29zx1u	91	8	population	population	NN
cord-310748-ao29zx1u	91	9	could	could	MD
cord-310748-ao29zx1u	91	10	be	be	VB
cord-310748-ao29zx1u	91	11	altered	alter	VBN
cord-310748-ao29zx1u	91	12	by	by	IN
cord-310748-ao29zx1u	91	13	passage	passage	NN
cord-310748-ao29zx1u	91	14	in	in	IN
cord-310748-ao29zx1u	91	15	tissue	tissue	NN
cord-310748-ao29zx1u	91	16	culture	culture	NN
cord-310748-ao29zx1u	91	17	.	.	.
cord-310748-ao29zx1u	92	1	DBT	DBT	NNP
cord-310748-ao29zx1u	92	2	cells	cell	NNS
cord-310748-ao29zx1u	92	3	were	be	VBD
cord-310748-ao29zx1u	92	4	infected	infect	VBN
cord-310748-ao29zx1u	92	5	with	with	IN
cord-310748-ao29zx1u	92	6	the	the	DT
cord-310748-ao29zx1u	92	7	virus	virus	NN
cord-310748-ao29zx1u	92	8	harvested	harvest	VBN
cord-310748-ao29zx1u	92	9	from	from	IN
cord-310748-ao29zx1u	92	10	the	the	DT
cord-310748-ao29zx1u	92	11	coinfected	coinfected	JJ
cord-310748-ao29zx1u	92	12	cells	cell	NNS
cord-310748-ao29zx1u	92	13	as	as	IN
cord-310748-ao29zx1u	92	14	described	describe	VBN
cord-310748-ao29zx1u	92	15	above	above	RB
cord-310748-ao29zx1u	92	16	.	.	.
cord-310748-ao29zx1u	93	1	The	the	DT
cord-310748-ao29zx1u	93	2	su-	su-	JJ
cord-310748-ao29zx1u	93	3	pernatant	pernatant	NN
cord-310748-ao29zx1u	93	4	from	from	IN
cord-310748-ao29zx1u	93	5	this	this	DT
cord-310748-ao29zx1u	93	6	infection	infection	NN
cord-310748-ao29zx1u	93	7	,	,	,
cord-310748-ao29zx1u	93	8	termed	term	VBD
cord-310748-ao29zx1u	93	9	Passage	passage	NN
cord-310748-ao29zx1u	93	10	1	1	CD
cord-310748-ao29zx1u	93	11	,	,	,
cord-310748-ao29zx1u	93	12	was	be	VBD
cord-310748-ao29zx1u	93	13	harvested	harvest	VBN
cord-310748-ao29zx1u	93	14	and	and	CC
cord-310748-ao29zx1u	93	15	the	the	DT
cord-310748-ao29zx1u	93	16	progeny	progeny	JJ
cord-310748-ao29zx1u	93	17	virions	virion	NNS
cord-310748-ao29zx1u	93	18	were	be	VBD
cord-310748-ao29zx1u	93	19	purif&d	purif&d	VBN
cord-310748-ao29zx1u	93	20	.	.	.
cord-310748-ao29zx1u	94	1	Viral	viral	JJ
cord-310748-ao29zx1u	94	2	genomic	genomic	NN
cord-310748-ao29zx1u	94	3	RNA	RNA	NNP
cord-310748-ao29zx1u	94	4	was	be	VBD
cord-310748-ao29zx1u	94	5	isolated	isolate	VBN
cord-310748-ao29zx1u	94	6	and	and	CC
cord-310748-ao29zx1u	94	7	amp#ed	amp#ed	.
cord-310748-ao29zx1u	94	8	by	by	IN
cord-310748-ao29zx1u	94	9	PCR	PCR	NNP
cord-310748-ao29zx1u	94	10	using	use	VBG
cord-310748-ao29zx1u	94	11	the	the	DT
cord-310748-ao29zx1u	94	12	same	same	JJ
cord-310748-ao29zx1u	94	13	primers	primer	NNS
cord-310748-ao29zx1u	94	14	described	describe	VBN
cord-310748-ao29zx1u	94	15	previously	previously	RB
cord-310748-ao29zx1u	94	16	.	.	.
cord-310748-ao29zx1u	95	1	The	the	DT
cord-310748-ao29zx1u	95	2	specific	specific	JJ
cord-310748-ao29zx1u	95	3	950-bp	950-bp	CD
cord-310748-ao29zx1u	95	4	PCR	PCR	NNP
cord-310748-ao29zx1u	95	5	product	product	NN
cord-310748-ao29zx1u	95	6	representing	represent	VBG
cord-310748-ao29zx1u	95	7	the	the	DT
cord-310748-ao29zx1u	95	8	recombinant	recombinant	JJ
cord-310748-ao29zx1u	95	9	RNA	RNA	NNP
cord-310748-ao29zx1u	95	10	was	be	VBD
cord-310748-ao29zx1u	95	11	again	again	RB
cord-310748-ao29zx1u	95	12	detected	detect	VBN
cord-310748-ao29zx1u	95	13	(	(	-LRB-
cord-310748-ao29zx1u	95	14	data	datum	NNS
cord-310748-ao29zx1u	95	15	not	not	RB
cord-310748-ao29zx1u	95	16	shown	show	VBN
cord-310748-ao29zx1u	95	17	)	)	-RRB-
cord-310748-ao29zx1u	95	18	.	.	.
cord-310748-ao29zx1u	96	1	Sequence	sequence	NN
cord-310748-ao29zx1u	96	2	analysis	analysis	NN
cord-310748-ao29zx1u	96	3	of	of	IN
cord-310748-ao29zx1u	96	4	34	34	CD
cord-310748-ao29zx1u	96	5	recombinants	recombinant	NNS
cord-310748-ao29zx1u	96	6	showed	show	VBD
cord-310748-ao29zx1u	96	7	that	that	IN
cord-310748-ao29zx1u	96	8	crossover	crossover	NN
cord-310748-ao29zx1u	96	9	sites	site	NNS
cord-310748-ao29zx1u	96	10	were	be	VBD
cord-310748-ao29zx1u	96	11	detected	detect	VBN
cord-310748-ao29zx1u	96	12	throughout	throughout	IN
cord-310748-ao29zx1u	96	13	the	the	DT
cord-310748-ao29zx1u	96	14	1	1	CD
cord-310748-ao29zx1u	96	15	-kb	-kb	NNPS
cord-310748-ao29zx1u	96	16	region	region	NN
cord-310748-ao29zx1u	96	17	;	;	:
cord-310748-ao29zx1u	96	18	however	however	RB
cord-310748-ao29zx1u	96	19	,	,	,
cord-310748-ao29zx1u	96	20	a	a	DT
cord-310748-ao29zx1u	96	21	large	large	JJ
cord-310748-ao29zx1u	96	22	proportion	proportion	NN
cord-310748-ao29zx1u	96	23	(	(	-LRB-
cord-310748-ao29zx1u	96	24	67	67	CD
cord-310748-ao29zx1u	96	25	%	%	NN
cord-310748-ao29zx1u	96	26	)	)	-RRB-
cord-310748-ao29zx1u	96	27	were	be	VBD
cord-310748-ao29zx1u	96	28	clustered	cluster	VBN
cord-310748-ao29zx1u	96	29	within	within	IN
cord-310748-ao29zx1u	96	30	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	96	31	1000-l	1000-l	CD
cord-310748-ao29zx1u	96	32	350	350	CD
cord-310748-ao29zx1u	96	33	.	.	.
cord-310748-ao29zx1u	97	1	This	this	DT
cord-310748-ao29zx1u	97	2	is	be	VBZ
cord-310748-ao29zx1u	97	3	in	in	IN
cord-310748-ao29zx1u	97	4	contrast	contrast	NN
cord-310748-ao29zx1u	97	5	to	to	IN
cord-310748-ao29zx1u	97	6	40	40	CD
cord-310748-ao29zx1u	97	7	%	%	NN
cord-310748-ao29zx1u	97	8	in	in	IN
cord-310748-ao29zx1u	97	9	the	the	DT
cord-310748-ao29zx1u	97	10	same	same	JJ
cord-310748-ao29zx1u	97	11	region	region	NN
cord-310748-ao29zx1u	97	12	for	for	IN
cord-310748-ao29zx1u	97	13	intracellular	intracellular	JJ
cord-310748-ao29zx1u	97	14	recombinant	recombinant	JJ
cord-310748-ao29zx1u	97	15	RNA	RNA	NNP
cord-310748-ao29zx1u	97	16	and	and	CC
cord-310748-ao29zx1u	97	17	47.1	47.1	CD
cord-310748-ao29zx1u	97	18	%	%	NN
cord-310748-ao29zx1u	97	19	for	for	IN
cord-310748-ao29zx1u	97	20	the	the	DT
cord-310748-ao29zx1u	97	21	recombinants	recombinant	NNS
cord-310748-ao29zx1u	97	22	detected	detect	VBN
cord-310748-ao29zx1u	97	23	in	in	IN
cord-310748-ao29zx1u	97	24	&	&	CC
cord-310748-ao29zx1u	97	25	ion	ion	NNP
cord-310748-ao29zx1u	97	26	RNA	RNA	NNP
cord-310748-ao29zx1u	97	27	before	before	IN
cord-310748-ao29zx1u	97	28	passage	passage	NN
cord-310748-ao29zx1u	97	29	(	(	-LRB-
cord-310748-ao29zx1u	97	30	Fig	Fig	NNP
cord-310748-ao29zx1u	97	31	.	.	.
cord-310748-ao29zx1u	97	32	2C	2C	NNP
cord-310748-ao29zx1u	97	33	)	)	-RRB-
cord-310748-ao29zx1u	97	34	.	.	.
cord-310748-ao29zx1u	98	1	These	these	DT
cord-310748-ao29zx1u	98	2	data	datum	NNS
cord-310748-ao29zx1u	98	3	suggest	suggest	VBP
cord-310748-ao29zx1u	98	4	that	that	IN
cord-310748-ao29zx1u	98	5	some	some	DT
cord-310748-ao29zx1u	98	6	FIG	fig	NN
cord-310748-ao29zx1u	98	7	.	.	.
cord-310748-ao29zx1u	99	1	3	3	LS
cord-310748-ao29zx1u	99	2	.	.	.
cord-310748-ao29zx1u	100	1	Diagram	Diagram	NNP
cord-310748-ao29zx1u	100	2	of	of	IN
cord-310748-ao29zx1u	100	3	sequences	sequence	NNS
cord-310748-ao29zx1u	100	4	around	around	IN
cord-310748-ao29zx1u	100	5	the	the	DT
cord-310748-ao29zx1u	100	6	crossover	crossover	NN
cord-310748-ao29zx1u	100	7	site	site	NN
cord-310748-ao29zx1u	100	8	of	of	IN
cord-310748-ao29zx1u	100	9	the	the	DT
cord-310748-ao29zx1u	100	10	recombinant	recombinant	JJ
cord-310748-ao29zx1u	100	11	i	i	NNP
cord-310748-ao29zx1u	100	12	-	-	HYPH
cord-310748-ao29zx1u	100	13	l	l	NNP
cord-310748-ao29zx1u	100	14	4	4	CD
cord-310748-ao29zx1u	100	15	,	,	,
cord-310748-ao29zx1u	100	16	which	which	WDT
cord-310748-ao29zx1u	100	17	had	have	VBD
cord-310748-ao29zx1u	100	18	a	a	DT
cord-310748-ao29zx1u	100	19	deletion	deletion	NN
cord-310748-ao29zx1u	100	20	.	.	.
cord-310748-ao29zx1u	101	1	Both	both	DT
cord-310748-ao29zx1u	101	2	JHM	JHM	NNP
cord-310748-ao29zx1u	101	3	-	-	HYPH
cord-310748-ao29zx1u	101	4	DL	DL	NNP
cord-310748-ao29zx1u	101	5	and	and	CC
cord-310748-ao29zx1u	101	6	A59	A59	NNP
cord-310748-ao29zx1u	101	7	parental	parental	JJ
cord-310748-ao29zx1u	101	8	RNAs	rna	NNS
cord-310748-ao29zx1u	101	9	were	be	VBD
cord-310748-ao29zx1u	101	10	compared	compare	VBN
cord-310748-ao29zx1u	101	11	with	with	IN
cord-310748-ao29zx1u	101	12	clone	clone	NN
cord-310748-ao29zx1u	101	13	l	l	NNP
cord-310748-ao29zx1u	101	14	-	-	HYPH
cord-310748-ao29zx1u	101	15	l	l	NNP
cord-310748-ao29zx1u	101	16	4	4	CD
cord-310748-ao29zx1u	101	17	in	in	IN
cord-310748-ao29zx1u	101	18	the	the	DT
cord-310748-ao29zx1u	101	19	region	region	NN
cord-310748-ao29zx1u	101	20	from	from	IN
cord-310748-ao29zx1u	101	21	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	101	22	1346	1346	CD
cord-310748-ao29zx1u	101	23	to	to	IN
cord-310748-ao29zx1u	101	24	1407	1407	CD
cord-310748-ao29zx1u	101	25	from	from	IN
cord-310748-ao29zx1u	101	26	the	the	DT
cord-310748-ao29zx1u	101	27	5'-end	5'-end	CD
cord-310748-ao29zx1u	101	28	of	of	IN
cord-310748-ao29zx1u	101	29	the	the	DT
cord-310748-ao29zx1u	101	30	peplomer	peplomer	NNP
cord-310748-ao29zx1u	101	31	gene	gene	NN
cord-310748-ao29zx1u	101	32	.	.	.
cord-310748-ao29zx1u	102	1	Thick	thick	JJ
cord-310748-ao29zx1u	102	2	lines	line	NNS
cord-310748-ao29zx1u	102	3	underneath	underneath	IN
cord-310748-ao29zx1u	102	4	the	the	DT
cord-310748-ao29zx1u	102	5	sequences	sequence	NNS
cord-310748-ao29zx1u	102	6	represent	represent	VBP
cord-310748-ao29zx1u	102	7	JHM	JHM	NNP
cord-310748-ao29zx1u	102	8	-	-	HYPH
cord-310748-ao29zx1u	102	9	DL	dl	NN
cord-310748-ao29zx1u	102	10	-	-	HYPH
cord-310748-ao29zx1u	102	11	specific	specific	JJ
cord-310748-ao29zx1u	102	12	sequences	sequence	NNS
cord-310748-ao29zx1u	102	13	,	,	,
cord-310748-ao29zx1u	102	14	and	and	CC
cord-310748-ao29zx1u	102	15	thin	thin	JJ
cord-310748-ao29zx1u	102	16	lines	line	NNS
cord-310748-ao29zx1u	102	17	represent	represent	VBP
cord-310748-ao29zx1u	102	18	A59-specific	A59-specific	NNP
cord-310748-ao29zx1u	102	19	sequences	sequence	NNS
cord-310748-ao29zx1u	102	20	.	.	.
cord-310748-ao29zx1u	103	1	Boxed	boxed	JJ
cord-310748-ao29zx1u	103	2	areas	area	NNS
cord-310748-ao29zx1u	103	3	are	be	VBP
cord-310748-ao29zx1u	103	4	6-nt	6-nt	CD
cord-310748-ao29zx1u	103	5	repeats	repeat	NNS
cord-310748-ao29zx1u	103	6	flanking	flank	VBG
cord-310748-ao29zx1u	103	7	the	the	DT
cord-310748-ao29zx1u	103	8	deletion	deletion	NN
cord-310748-ao29zx1u	103	9	.	.	.
cord-310748-ao29zx1u	104	1	Placement	placement	NN
cord-310748-ao29zx1u	104	2	of	of	IN
cord-310748-ao29zx1u	104	3	the	the	DT
cord-310748-ao29zx1u	104	4	boxed	boxed	JJ
cord-310748-ao29zx1u	104	5	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	104	6	in	in	IN
cord-310748-ao29zx1u	104	7	l	l	NNP
cord-310748-ao29zx1u	104	8	-	-	HYPH
cord-310748-ao29zx1u	104	9	l	l	NNP
cord-310748-ao29zx1u	104	10	4	4	CD
cord-310748-ao29zx1u	104	11	is	be	VBZ
cord-310748-ao29zx1u	104	12	arbitrary	arbitrary	JJ
cord-310748-ao29zx1u	104	13	.	.	.
cord-310748-ao29zx1u	105	1	Dots	dot	NNS
cord-310748-ao29zx1u	105	2	in	in	IN
cord-310748-ao29zx1u	105	3	l-14	l-14	NNP
cord-310748-ao29zx1u	105	4	denote	denote	VBP
cord-310748-ao29zx1u	105	5	deleted	delete	VBN
cord-310748-ao29zx1u	105	6	area	area	NN
cord-310748-ao29zx1u	105	7	.	.	.
cord-310748-ao29zx1u	106	1	recombinant	recombinant	JJ
cord-310748-ao29zx1u	106	2	RNA	RNA	NNP
cord-310748-ao29zx1u	106	3	molecules	molecule	NNS
cord-310748-ao29zx1u	106	4	may	may	MD
cord-310748-ao29zx1u	106	5	have	have	VB
cord-310748-ao29zx1u	106	6	selective	selective	JJ
cord-310748-ao29zx1u	106	7	disadvantages	disadvantage	NNS
cord-310748-ao29zx1u	106	8	during	during	IN
cord-310748-ao29zx1u	106	9	subsequent	subsequent	JJ
cord-310748-ao29zx1u	106	10	infection	infection	NN
cord-310748-ao29zx1u	106	11	.	.	.
cord-310748-ao29zx1u	107	1	After	after	IN
cord-310748-ao29zx1u	107	2	two	two	CD
cord-310748-ao29zx1u	107	3	additional	additional	JJ
cord-310748-ao29zx1u	107	4	passages	passage	NNS
cord-310748-ao29zx1u	107	5	,	,	,
cord-310748-ao29zx1u	107	6	an	an	DT
cord-310748-ao29zx1u	107	7	even	even	RB
cord-310748-ao29zx1u	107	8	greater	great	JJR
cord-310748-ao29zx1u	107	9	proportion	proportion	NN
cord-310748-ao29zx1u	107	10	(	(	-LRB-
cord-310748-ao29zx1u	107	11	79.2	79.2	CD
cord-310748-ao29zx1u	107	12	%	%	NN
cord-310748-ao29zx1u	107	13	)	)	-RRB-
cord-310748-ao29zx1u	107	14	of	of	IN
cord-310748-ao29zx1u	107	15	the	the	DT
cord-310748-ao29zx1u	107	16	crossover	crossover	NN
cord-310748-ao29zx1u	107	17	sites	site	NNS
cord-310748-ao29zx1u	107	18	were	be	VBD
cord-310748-ao29zx1u	107	19	localized	localize	VBN
cord-310748-ao29zx1u	107	20	within	within	IN
cord-310748-ao29zx1u	107	21	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	107	22	1000-l	1000-l	CD
cord-310748-ao29zx1u	107	23	350	350	CD
cord-310748-ao29zx1u	108	1	(	(	-LRB-
cord-310748-ao29zx1u	108	2	Fig	Fig	NNP
cord-310748-ao29zx1u	108	3	.	.	.
cord-310748-ao29zx1u	108	4	2D	2D	NNP
cord-310748-ao29zx1u	108	5	)	)	-RRB-
cord-310748-ao29zx1u	108	6	.	.	.
cord-310748-ao29zx1u	109	1	By	by	IN
cord-310748-ao29zx1u	109	2	the	the	DT
cord-310748-ao29zx1u	109	3	fourth	fourth	JJ
cord-310748-ao29zx1u	109	4	passage	passage	NN
cord-310748-ao29zx1u	109	5	,	,	,
cord-310748-ao29zx1u	109	6	no	no	DT
cord-310748-ao29zx1u	109	7	recombinant	recombinant	JJ
cord-310748-ao29zx1u	109	8	RNA	rna	NN
cord-310748-ao29zx1u	109	9	molecules	molecule	NNS
cord-310748-ao29zx1u	109	10	could	could	MD
cord-310748-ao29zx1u	109	11	be	be	VB
cord-310748-ao29zx1u	109	12	detected	detect	VBN
cord-310748-ao29zx1u	109	13	by	by	IN
cord-310748-ao29zx1u	109	14	PCR	PCR	NNP
cord-310748-ao29zx1u	109	15	amplification	amplification	NN
cord-310748-ao29zx1u	109	16	(	(	-LRB-
cord-310748-ao29zx1u	109	17	data	datum	NNS
cord-310748-ao29zx1u	109	18	not	not	RB
cord-310748-ao29zx1u	109	19	shown	show	VBN
cord-310748-ao29zx1u	109	20	)	)	-RRB-
cord-310748-ao29zx1u	109	21	.	.	.
cord-310748-ao29zx1u	110	1	This	this	DT
cord-310748-ao29zx1u	110	2	result	result	NN
cord-310748-ao29zx1u	110	3	suggests	suggest	VBZ
cord-310748-ao29zx1u	110	4	that	that	IN
cord-310748-ao29zx1u	110	5	the	the	DT
cord-310748-ao29zx1u	110	6	recombinant	recombinant	JJ
cord-310748-ao29zx1u	110	7	viral	viral	JJ
cord-310748-ao29zx1u	110	8	RNAs	rna	NNS
cord-310748-ao29zx1u	110	9	which	which	WDT
cord-310748-ao29zx1u	110	10	have	have	VBP
cord-310748-ao29zx1u	110	11	crossovers	crossover	NNS
cord-310748-ao29zx1u	110	12	within	within	IN
cord-310748-ao29zx1u	110	13	the	the	DT
cord-310748-ao29zx1u	110	14	peplomer	peplomer	JJ
cord-310748-ao29zx1u	110	15	gene	gene	NN
cord-310748-ao29zx1u	110	16	may	may	MD
cord-310748-ao29zx1u	110	17	have	have	VB
cord-310748-ao29zx1u	110	18	a	a	DT
cord-310748-ao29zx1u	110	19	growth	growth	NN
cord-310748-ao29zx1u	110	20	disadvantage	disadvantage	NN
cord-310748-ao29zx1u	110	21	under	under	IN
cord-310748-ao29zx1u	110	22	the	the	DT
cord-310748-ao29zx1u	110	23	culture	culture	NN
cord-310748-ao29zx1u	110	24	conditions	condition	NNS
cord-310748-ao29zx1u	110	25	.	.	.
cord-310748-ao29zx1u	111	1	One	one	CD
cord-310748-ao29zx1u	111	2	possible	possible	JJ
cord-310748-ao29zx1u	111	3	reason	reason	NN
cord-310748-ao29zx1u	111	4	may	may	MD
cord-310748-ao29zx1u	111	5	be	be	VB
cord-310748-ao29zx1u	111	6	that	that	IN
cord-310748-ao29zx1u	111	7	one	one	CD
cord-310748-ao29zx1u	111	8	of	of	IN
cord-310748-ao29zx1u	111	9	the	the	DT
cord-310748-ao29zx1u	111	10	parental	parental	JJ
cord-310748-ao29zx1u	111	11	viruses	virus	NNS
cord-310748-ao29zx1u	111	12	,	,	,
cord-310748-ao29zx1u	111	13	A59	A59	NNP
cord-310748-ao29zx1u	111	14	,	,	,
cord-310748-ao29zx1u	111	15	had	have	VBD
cord-310748-ao29zx1u	111	16	more	more	RBR
cord-310748-ao29zx1u	111	17	efficient	efficient	JJ
cord-310748-ao29zx1u	111	18	growth	growth	NN
cord-310748-ao29zx1u	111	19	properties	property	NNS
cord-310748-ao29zx1u	111	20	in	in	IN
cord-310748-ao29zx1u	111	21	cell	cell	NN
cord-310748-ao29zx1u	111	22	culture	culture	NN
cord-310748-ao29zx1u	111	23	.	.	.
cord-310748-ao29zx1u	112	1	The	the	DT
cord-310748-ao29zx1u	112	2	other	other	JJ
cord-310748-ao29zx1u	112	3	parental	parental	JJ
cord-310748-ao29zx1u	112	4	virus	virus	NN
cord-310748-ao29zx1u	112	5	,	,	,
cord-310748-ao29zx1u	112	6	JHM	JHM	NNP
cord-310748-ao29zx1u	112	7	-	-	HYPH
cord-310748-ao29zx1u	112	8	DL	DL	NNP
cord-310748-ao29zx1u	112	9	,	,	,
cord-310748-ao29zx1u	112	10	was	be	VBD
cord-310748-ao29zx1u	112	11	affected	affect	VBN
cord-310748-ao29zx1u	112	12	much	much	RB
cord-310748-ao29zx1u	112	13	like	like	IN
cord-310748-ao29zx1u	112	14	the	the	DT
cord-310748-ao29zx1u	112	15	recombinants	recombinant	NNS
cord-310748-ao29zx1u	112	16	,	,	,
cord-310748-ao29zx1u	112	17	in	in	IN
cord-310748-ao29zx1u	112	18	that	that	DT
cord-310748-ao29zx1u	112	19	no	no	DT
cord-310748-ao29zx1u	112	20	JHM	JHM	NNP
cord-310748-ao29zx1u	112	21	-	-	HYPH
cord-310748-ao29zx1u	112	22	DL	DL	NNP
cord-310748-ao29zx1u	112	23	RNA	RNA	NNP
cord-310748-ao29zx1u	112	24	could	could	MD
cord-310748-ao29zx1u	112	25	be	be	VB
cord-310748-ao29zx1u	112	26	detected	detect	VBN
cord-310748-ao29zx1u	112	27	after	after	IN
cord-310748-ao29zx1u	112	28	Passage	passage	NN
cord-310748-ao29zx1u	112	29	5	5	CD
cord-310748-ao29zx1u	112	30	.	.	.
cord-310748-ao29zx1u	113	1	This	this	DT
cord-310748-ao29zx1u	113	2	study	study	NN
cord-310748-ao29zx1u	113	3	examined	examine	VBD
cord-310748-ao29zx1u	113	4	,	,	,
cord-310748-ao29zx1u	113	5	for	for	IN
cord-310748-ao29zx1u	113	6	the	the	DT
cord-310748-ao29zx1u	113	7	first	first	JJ
cord-310748-ao29zx1u	113	8	time	time	NN
cord-310748-ao29zx1u	113	9	,	,	,
cord-310748-ao29zx1u	113	10	RNA	rna	NN
cord-310748-ao29zx1u	113	11	recombination	recombination	NN
cord-310748-ao29zx1u	113	12	occurring	occur	VBG
cord-310748-ao29zx1u	113	13	in	in	IN
cord-310748-ao29zx1u	113	14	the	the	DT
cord-310748-ao29zx1u	113	15	absence	absence	NN
cord-310748-ao29zx1u	113	16	of	of	IN
cord-310748-ao29zx1u	113	17	artificial	artificial	JJ
cord-310748-ao29zx1u	113	18	selection	selection	NN
cord-310748-ao29zx1u	113	19	pressures	pressure	NNS
cord-310748-ao29zx1u	113	20	.	.	.
cord-310748-ao29zx1u	114	1	It	-PRON-	PRP
cord-310748-ao29zx1u	114	2	was	be	VBD
cord-310748-ao29zx1u	114	3	surprising	surprising	JJ
cord-310748-ao29zx1u	114	4	that	that	IN
cord-310748-ao29zx1u	114	5	the	the	DT
cord-310748-ao29zx1u	114	6	recombination	recombination	NN
cord-310748-ao29zx1u	114	7	sites	site	NNS
cord-310748-ao29zx1u	114	8	within	within	IN
cord-310748-ao29zx1u	114	9	the	the	DT
cord-310748-ao29zx1u	114	10	l	l	NNP
cord-310748-ao29zx1u	114	11	-	-	HYPH
cord-310748-ao29zx1u	114	12	kb	kb	NNP
cord-310748-ao29zx1u	114	13	stretch	stretch	NN
cord-310748-ao29zx1u	114	14	of	of	IN
cord-310748-ao29zx1u	114	15	the	the	DT
cord-310748-ao29zx1u	114	16	peplomer	peplomer	JJ
cord-310748-ao29zx1u	114	17	gene	gene	NN
cord-310748-ao29zx1u	114	18	appeared	appear	VBD
cord-310748-ao29zx1u	114	19	to	to	TO
cord-310748-ao29zx1u	114	20	be	be	VB
cord-310748-ao29zx1u	114	21	almost	almost	RB
cord-310748-ao29zx1u	114	22	completely	completely	RB
cord-310748-ao29zx1u	114	23	random	random	JJ
cord-310748-ao29zx1u	114	24	under	under	IN
cord-310748-ao29zx1u	114	25	these	these	DT
cord-310748-ao29zx1u	114	26	conditions	condition	NNS
cord-310748-ao29zx1u	114	27	.	.	.
cord-310748-ao29zx1u	115	1	Recombination	recombination	NN
cord-310748-ao29zx1u	115	2	was	be	VBD
cord-310748-ao29zx1u	115	3	detected	detect	VBN
cord-310748-ao29zx1u	115	4	at	at	IN
cord-310748-ao29zx1u	115	5	the	the	DT
cord-310748-ao29zx1u	115	6	majority	majority	NN
cord-310748-ao29zx1u	115	7	of	of	IN
cord-310748-ao29zx1u	115	8	the	the	DT
cord-310748-ao29zx1u	115	9	potential	potential	JJ
cord-310748-ao29zx1u	115	10	crossover	crossover	NN
cord-310748-ao29zx1u	115	11	sites	site	NNS
cord-310748-ao29zx1u	115	12	;	;	:
cord-310748-ao29zx1u	115	13	thus	thus	RB
cord-310748-ao29zx1u	115	14	,	,	,
cord-310748-ao29zx1u	115	15	there	there	EX
cord-310748-ao29zx1u	115	16	were	be	VBD
cord-310748-ao29zx1u	115	17	no	no	DT
cord-310748-ao29zx1u	115	18	apparent	apparent	JJ
cord-310748-ao29zx1u	115	19	sequence	sequence	NN
cord-310748-ao29zx1u	115	20	motifs	motif	NNS
cord-310748-ao29zx1u	115	21	or	or	CC
cord-310748-ao29zx1u	115	22	repeated	repeat	VBN
cord-310748-ao29zx1u	115	23	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	115	24	required	require	VBN
cord-310748-ao29zx1u	115	25	for	for	IN
cord-310748-ao29zx1u	115	26	recombination	recombination	NN
cord-310748-ao29zx1u	115	27	,	,	,
cord-310748-ao29zx1u	115	28	except	except	IN
cord-310748-ao29zx1u	115	29	in	in	IN
cord-310748-ao29zx1u	115	30	the	the	DT
cord-310748-ao29zx1u	115	31	recombinant	recombinant	NN
cord-310748-ao29zx1u	115	32	noted	note	VBN
cord-310748-ao29zx1u	115	33	above	above	RB
cord-310748-ao29zx1u	115	34	,	,	,
cord-310748-ao29zx1u	115	35	which	which	WDT
cord-310748-ao29zx1u	115	36	had	have	VBD
cord-310748-ao29zx1u	115	37	a	a	DT
cord-310748-ao29zx1u	115	38	deletion	deletion	NN
cord-310748-ao29zx1u	115	39	accompanying	accompany	VBG
cord-310748-ao29zx1u	115	40	the	the	DT
cord-310748-ao29zx1u	115	41	crossover	crossover	NN
cord-310748-ao29zx1u	115	42	.	.	.
cord-310748-ao29zx1u	116	1	All	all	DT
cord-310748-ao29zx1u	116	2	of	of	IN
cord-310748-ao29zx1u	116	3	the	the	DT
cord-310748-ao29zx1u	116	4	recombination	recombination	NN
cord-310748-ao29zx1u	116	5	events	event	NNS
cord-310748-ao29zx1u	116	6	examined	examine	VBN
cord-310748-ao29zx1u	116	7	were	be	VBD
cord-310748-ao29zx1u	116	8	the	the	DT
cord-310748-ao29zx1u	116	9	result	result	NN
cord-310748-ao29zx1u	116	10	of	of	IN
cord-310748-ao29zx1u	116	11	homologous	homologous	JJ
cord-310748-ao29zx1u	116	12	recombination	recombination	NN
cord-310748-ao29zx1u	116	13	,	,	,
cord-310748-ao29zx1u	116	14	which	which	WDT
cord-310748-ao29zx1u	116	15	preserved	preserve	VBD
cord-310748-ao29zx1u	116	16	the	the	DT
cord-310748-ao29zx1u	116	17	open	open	JJ
cord-310748-ao29zx1u	116	18	reading	reading	NN
cord-310748-ao29zx1u	116	19	frame	frame	NN
cord-310748-ao29zx1u	116	20	of	of	IN
cord-310748-ao29zx1u	116	21	the	the	DT
cord-310748-ao29zx1u	116	22	peplomer	peplomer	JJ
cord-310748-ao29zx1u	116	23	gene	gene	NN
cord-310748-ao29zx1u	116	24	.	.	.
cord-310748-ao29zx1u	117	1	One	one	CD
cord-310748-ao29zx1u	117	2	particular	particular	JJ
cord-310748-ao29zx1u	117	3	recombinant	recombinant	NN
cord-310748-ao29zx1u	117	4	had	have	VBD
cord-310748-ao29zx1u	117	5	a	a	DT
cord-310748-ao29zx1u	117	6	crossover	crossover	NN
cord-310748-ao29zx1u	117	7	between	between	IN
cord-310748-ao29zx1u	117	8	two	two	CD
cord-310748-ao29zx1u	117	9	adjoining	adjoining	JJ
cord-310748-ao29zx1u	117	10	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	117	11	which	which	WDT
cord-310748-ao29zx1u	117	12	differ	differ	VBP
cord-310748-ao29zx1u	117	13	between	between	IN
cord-310748-ao29zx1u	117	14	the	the	DT
cord-310748-ao29zx1u	117	15	two	two	CD
cord-310748-ao29zx1u	117	16	parental	parental	JJ
cord-310748-ao29zx1u	117	17	RNAs	rna	NNS
cord-310748-ao29zx1u	117	18	(	(	-LRB-
cord-310748-ao29zx1u	117	19	Fig	Fig	NNP
cord-310748-ao29zx1u	117	20	.	.	.
cord-310748-ao29zx1u	117	21	4A	4a	CD
cord-310748-ao29zx1u	117	22	)	)	-RRB-
cord-310748-ao29zx1u	117	23	.	.	.
cord-310748-ao29zx1u	118	1	A	a	DT
cord-310748-ao29zx1u	118	2	few	few	JJ
cord-310748-ao29zx1u	118	3	more	more	JJR
cord-310748-ao29zx1u	118	4	had	have	VBD
cord-310748-ao29zx1u	118	5	crossover	crossover	NN
cord-310748-ao29zx1u	118	6	sites	site	NNS
cord-310748-ao29zx1u	118	7	with	with	IN
cord-310748-ao29zx1u	118	8	only	only	RB
cord-310748-ao29zx1u	118	9	1	1	CD
cord-310748-ao29zx1u	118	10	or	or	CC
cord-310748-ao29zx1u	118	11	2	2	CD
cord-310748-ao29zx1u	118	12	nt	nt	RB
cord-310748-ao29zx1u	118	13	separating	separate	VBG
cord-310748-ao29zx1u	118	14	the	the	DT
cord-310748-ao29zx1u	118	15	divergent	divergent	JJ
cord-310748-ao29zx1u	118	16	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	118	17	between	between	IN
cord-310748-ao29zx1u	118	18	the	the	DT
cord-310748-ao29zx1u	118	19	parental	parental	JJ
cord-310748-ao29zx1u	118	20	viruses	virus	NNS
cord-310748-ao29zx1u	118	21	(	(	-LRB-
cord-310748-ao29zx1u	118	22	Figs	fig	NNS
cord-310748-ao29zx1u	118	23	.	.	.
cord-310748-ao29zx1u	118	24	4B-4D	4b-4d	CD
cord-310748-ao29zx1u	118	25	)	)	-RRB-
cord-310748-ao29zx1u	118	26	.	.	.
cord-310748-ao29zx1u	119	1	Therefore	therefore	RB
cord-310748-ao29zx1u	119	2	,	,	,
cord-310748-ao29zx1u	119	3	extensive	extensive	JJ
cord-310748-ao29zx1u	119	4	sequence	sequence	NN
cord-310748-ao29zx1u	119	5	homology	homology	NN
cord-310748-ao29zx1u	119	6	between	between	IN
cord-310748-ao29zx1u	119	7	the	the	DT
cord-310748-ao29zx1u	119	8	two	two	CD
cord-310748-ao29zx1u	119	9	parental	parental	JJ
cord-310748-ao29zx1u	119	10	RNAs	rna	NNS
cord-310748-ao29zx1u	119	11	at	at	IN
cord-310748-ao29zx1u	119	12	the	the	DT
cord-310748-ao29zx1u	119	13	crossover	crossover	NN
cord-310748-ao29zx1u	119	14	sites	site	NNS
cord-310748-ao29zx1u	119	15	does	do	VBZ
cord-310748-ao29zx1u	119	16	not	not	RB
cord-310748-ao29zx1u	119	17	appear	appear	VB
cord-310748-ao29zx1u	119	18	to	to	TO
cord-310748-ao29zx1u	119	19	be	be	VB
cord-310748-ao29zx1u	119	20	required	require	VBN
cord-310748-ao29zx1u	119	21	for	for	IN
cord-310748-ao29zx1u	119	22	recombination	recombination	NN
cord-310748-ao29zx1u	119	23	.	.	.
cord-310748-ao29zx1u	120	1	The	the	DT
cord-310748-ao29zx1u	120	2	same	same	JJ
cord-310748-ao29zx1u	120	3	conclusion	conclusion	NN
cord-310748-ao29zx1u	120	4	has	have	VBZ
cord-310748-ao29zx1u	120	5	been	be	VBN
cord-310748-ao29zx1u	120	6	reached	reach	VBN
cord-310748-ao29zx1u	120	7	with	with	IN
cord-310748-ao29zx1u	120	8	poliovirus	poliovirus	NN
cord-310748-ao29zx1u	120	9	RNA	RNA	NNP
cord-310748-ao29zx1u	120	10	recombination	recombination	NN
cord-310748-ao29zx1u	120	11	(	(	-LRB-
cord-310748-ao29zx1u	120	12	3	3	CD
cord-310748-ao29zx1u	120	13	)	)	-RRB-
cord-310748-ao29zx1u	120	14	.	.	.
cord-310748-ao29zx1u	121	1	These	these	DT
cord-310748-ao29zx1u	121	2	results	result	NNS
cord-310748-ao29zx1u	121	3	further	further	RB
cord-310748-ao29zx1u	121	4	support	support	VBP
cord-310748-ao29zx1u	121	5	the	the	DT
cord-310748-ao29zx1u	121	6	observation	observation	NN
cord-310748-ao29zx1u	121	7	that	that	IN
cord-310748-ao29zx1u	121	8	coronavirus	coronavirus	NN
cord-310748-ao29zx1u	121	9	RNA	RNA	NNP
cord-310748-ao29zx1u	121	10	undergoes	undergo	VBZ
cord-310748-ao29zx1u	121	11	recombination	recombination	NN
cord-310748-ao29zx1u	121	12	at	at	IN
cord-310748-ao29zx1u	121	13	an	an	DT
cord-310748-ao29zx1u	121	14	extremely	extremely	RB
cord-310748-ao29zx1u	121	15	high	high	JJ
cord-310748-ao29zx1u	121	16	frequency	frequency	NN
cord-310748-ao29zx1u	121	17	(	(	-LRB-
cord-310748-ao29zx1u	121	18	5	5	CD
cord-310748-ao29zx1u	121	19	,	,	,
cord-310748-ao29zx1u	121	20	19	19	CD
cord-310748-ao29zx1u	121	21	)	)	-RRB-
cord-310748-ao29zx1u	121	22	.	.	.
cord-310748-ao29zx1u	122	1	However	however	RB
cord-310748-ao29zx1u	122	2	,	,	,
cord-310748-ao29zx1u	122	3	after	after	IN
cord-310748-ao29zx1u	122	4	only	only	RB
cord-310748-ao29zx1u	122	5	three	three	CD
cord-310748-ao29zx1u	122	6	virus	virus	NN
cord-310748-ao29zx1u	122	7	passages	passage	NNS
cord-310748-ao29zx1u	122	8	,	,	,
cord-310748-ao29zx1u	122	9	crossover	crossover	NN
cord-310748-ao29zx1u	122	10	sites	site	NNS
cord-310748-ao29zx1u	122	11	became	become	VBD
cord-310748-ao29zx1u	122	12	clustered	cluster	VBN
cord-310748-ao29zx1u	122	13	within	within	IN
cord-310748-ao29zx1u	122	14	a	a	DT
cord-310748-ao29zx1u	122	15	small	small	JJ
cord-310748-ao29zx1u	122	16	region	region	NN
cord-310748-ao29zx1u	122	17	,	,	,
cord-310748-ao29zx1u	122	18	suggesting	suggest	VBG
cord-310748-ao29zx1u	122	19	that	that	IN
cord-310748-ao29zx1u	122	20	certain	certain	JJ
cord-310748-ao29zx1u	122	21	RNA	RNA	NNP
cord-310748-ao29zx1u	122	22	crossover	crossover	NN
cord-310748-ao29zx1u	122	23	events	event	NNS
cord-310748-ao29zx1u	122	24	may	may	MD
cord-310748-ao29zx1u	122	25	lead	lead	VB
cord-310748-ao29zx1u	122	26	to	to	IN
cord-310748-ao29zx1u	122	27	more	more	RBR
cord-310748-ao29zx1u	122	28	favorable	favorable	JJ
cord-310748-ao29zx1u	122	29	recombinants	recombinant	NNS
cord-310748-ao29zx1u	122	30	.	.	.
cord-310748-ao29zx1u	123	1	This	this	DT
cord-310748-ao29zx1u	123	2	is	be	VBZ
cord-310748-ao29zx1u	123	3	consistent	consistent	JJ
cord-310748-ao29zx1u	123	4	with	with	IN
cord-310748-ao29zx1u	123	5	our	-PRON-	PRP$
cord-310748-ao29zx1u	123	6	previous	previous	JJ
cord-310748-ao29zx1u	123	7	finding	finding	NN
cord-310748-ao29zx1u	123	8	that	that	IN
cord-310748-ao29zx1u	123	9	,	,	,
cord-310748-ao29zx1u	123	10	when	when	WRB
cord-310748-ao29zx1u	123	11	selection	selection	NN
cord-310748-ao29zx1u	123	12	pressures	pressure	NNS
cord-310748-ao29zx1u	123	13	(	(	-LRB-
cord-310748-ao29zx1u	123	14	neutralization	neutralization	NN
cord-310748-ao29zx1u	123	15	by	by	IN
cord-310748-ao29zx1u	123	16	monoclonal	monoclonal	JJ
cord-310748-ao29zx1u	123	17	antibodies	antibody	NNS
cord-310748-ao29zx1u	123	18	and	and	CC
cord-310748-ao29zx1u	123	19	temperature	temperature	NN
cord-310748-ao29zx1u	123	20	-	-	HYPH
cord-310748-ao29zx1u	123	21	sensitivity	sensitivity	NN
cord-310748-ao29zx1u	123	22	in	in	IN
cord-310748-ao29zx1u	123	23	replication	replication	NN
cord-310748-ao29zx1u	123	24	)	)	-RRB-
cord-310748-ao29zx1u	123	25	were	be	VBD
cord-310748-ao29zx1u	123	26	used	use	VBN
cord-310748-ao29zx1u	123	27	,	,	,
cord-310748-ao29zx1u	123	28	all	all	DT
cord-310748-ao29zx1u	123	29	of	of	IN
cord-310748-ao29zx1u	123	30	the	the	DT
cord-310748-ao29zx1u	123	31	recombinants	recombinant	NNS
cord-310748-ao29zx1u	123	32	obtained	obtain	VBN
cord-310748-ao29zx1u	123	33	had	have	VBD
cord-310748-ao29zx1u	123	34	crossover	crossover	NN
cord-310748-ao29zx1u	123	35	sites	site	NNS
cord-310748-ao29zx1u	123	36	localized	localize	VBN
cord-310748-ao29zx1u	123	37	between	between	IN
cord-310748-ao29zx1u	123	38	nucleotides	nucleotide	NNS
cord-310748-ao29zx1u	123	39	1148	1148	CD
cord-310748-ao29zx1u	123	40	and	and	CC
cord-310748-ao29zx1u	123	41	1426	1426	CD
cord-310748-ao29zx1u	123	42	of	of	IN
cord-310748-ao29zx1u	123	43	the	the	DT
cord-310748-ao29zx1u	123	44	peplomer	peplomer	NNP
cord-310748-ao29zx1u	123	45	gene	gene	NN
cord-310748-ao29zx1u	123	46	,	,	,
cord-310748-ao29zx1u	123	47	even	even	RB
cord-310748-ao29zx1u	123	48	though	though	IN
cord-310748-ao29zx1u	123	49	the	the	DT
cord-310748-ao29zx1u	123	50	potential	potential	JJ
cord-310748-ao29zx1u	123	51	crossover	crossover	NN
cord-310748-ao29zx1u	123	52	region	region	NN
cord-310748-ao29zx1u	123	53	extended	extend	VBD
cord-310748-ao29zx1u	123	54	more	more	JJR
cord-310748-ao29zx1u	123	55	than	than	IN
cord-310748-ao29zx1u	123	56	1.5	1.5	CD
cord-310748-ao29zx1u	123	57	kb	kb	NNS
cord-310748-ao29zx1u	123	58	(	(	-LRB-
cord-310748-ao29zx1u	123	59	72	72	CD
cord-310748-ao29zx1u	123	60	)	)	-RRB-
cord-310748-ao29zx1u	123	61	.	.	.
cord-310748-ao29zx1u	124	1	One	one	CD
cord-310748-ao29zx1u	124	2	possible	possible	JJ
cord-310748-ao29zx1u	124	3	reason	reason	NN
cord-310748-ao29zx1u	124	4	for	for	IN
cord-310748-ao29zx1u	124	5	this	this	DT
cord-310748-ao29zx1u	124	6	selective	selective	JJ
cord-310748-ao29zx1u	124	7	localization	localization	NN
cord-310748-ao29zx1u	124	8	of	of	IN
cord-310748-ao29zx1u	124	9	crossover	crossover	NN
cord-310748-ao29zx1u	124	10	sites	site	NNS
cord-310748-ao29zx1u	124	11	is	be	VBZ
cord-310748-ao29zx1u	124	12	that	that	IN
cord-310748-ao29zx1u	124	13	certain	certain	JJ
cord-310748-ao29zx1u	124	14	regions	region	NNS
cord-310748-ao29zx1u	124	15	combining	combine	VBG
cord-310748-ao29zx1u	124	16	to	to	TO
cord-310748-ao29zx1u	124	17	make	make	VB
cord-310748-ao29zx1u	124	18	the	the	DT
cord-310748-ao29zx1u	124	19	hybrid	hybrid	JJ
cord-310748-ao29zx1u	124	20	peplomer	peplomer	JJ
cord-310748-ao29zx1u	124	21	protein	protein	NN
cord-310748-ao29zx1u	124	22	may	may	MD
cord-310748-ao29zx1u	124	23	be	be	VB
cord-310748-ao29zx1u	124	24	structurally	structurally	RB
cord-310748-ao29zx1u	124	25	incompatible	incompatible	JJ
cord-310748-ao29zx1u	124	26	so	so	IN
cord-310748-ao29zx1u	124	27	as	as	IN
cord-310748-ao29zx1u	124	28	to	to	TO
cord-310748-ao29zx1u	124	29	interfere	interfere	VB
cord-310748-ao29zx1u	124	30	with	with	IN
cord-310748-ao29zx1u	124	31	normal	normal	JJ
cord-310748-ao29zx1u	124	32	peplomer	peplomer	JJ
cord-310748-ao29zx1u	124	33	functions	function	NNS
cord-310748-ao29zx1u	124	34	,	,	,
cord-310748-ao29zx1u	124	35	such	such	JJ
cord-310748-ao29zx1u	124	36	as	as	IN
cord-310748-ao29zx1u	124	37	binding	bind	VBG
cord-310748-ao29zx1u	124	38	to	to	IN
cord-310748-ao29zx1u	124	39	cellular	cellular	JJ
cord-310748-ao29zx1u	124	40	receptors	receptor	NNS
cord-310748-ao29zx1u	124	41	.	.	.
cord-310748-ao29zx1u	125	1	Thus	thus	RB
cord-310748-ao29zx1u	125	2	,	,	,
cord-310748-ao29zx1u	125	3	the	the	DT
cord-310748-ao29zx1u	125	4	recombinational	recombinational	JJ
cord-310748-ao29zx1u	125	5	"	"	``
cord-310748-ao29zx1u	125	6	hot	hot	JJ
cord-310748-ao29zx1u	125	7	spot	spot	NN
cord-310748-ao29zx1u	125	8	"	"	''
cord-310748-ao29zx1u	125	9	observed	observe	VBD
cord-310748-ao29zx1u	125	10	previously	previously	RB
cord-310748-ao29zx1u	125	11	(	(	-LRB-
cord-310748-ao29zx1u	125	12	12	12	CD
cord-310748-ao29zx1u	125	13	)	)	-RRB-
cord-310748-ao29zx1u	125	14	most	most	RBS
cord-310748-ao29zx1u	125	15	likely	likely	RB
cord-310748-ao29zx1u	125	16	was	be	VBD
cord-310748-ao29zx1u	125	17	the	the	DT
cord-310748-ao29zx1u	125	18	result	result	NN
cord-310748-ao29zx1u	125	19	of	of	IN
cord-310748-ao29zx1u	125	20	functional	functional	JJ
cord-310748-ao29zx1u	125	21	constraints	constraint	NNS
cord-310748-ao29zx1u	125	22	on	on	IN
cord-310748-ao29zx1u	125	23	some	some	DT
cord-310748-ao29zx1u	125	24	of	of	IN
cord-310748-ao29zx1u	125	25	the	the	DT
cord-310748-ao29zx1u	125	26	recombinants	recombinant	NNS
cord-310748-ao29zx1u	125	27	,	,	,
cord-310748-ao29zx1u	125	28	rather	rather	RB
cord-310748-ao29zx1u	125	29	than	than	IN
cord-310748-ao29zx1u	125	30	a	a	DT
cord-310748-ao29zx1u	125	31	limitation	limitation	NN
cord-310748-ao29zx1u	125	32	of	of	IN
cord-310748-ao29zx1u	125	33	recombination	recombination	NN
cord-310748-ao29zx1u	125	34	events	event	NNS
cord-310748-ao29zx1u	125	35	caused	cause	VBN
cord-310748-ao29zx1u	125	36	by	by	IN
cord-310748-ao29zx1u	125	37	RNA	RNA	NNP
cord-310748-ao29zx1u	125	38	structure	structure	NN
cord-310748-ao29zx1u	125	39	.	.	.
cord-310748-ao29zx1u	126	1	Since	since	IN
cord-310748-ao29zx1u	126	2	the	the	DT
cord-310748-ao29zx1u	126	3	clustering	clustering	NN
cord-310748-ao29zx1u	126	4	site	site	NN
cord-310748-ao29zx1u	126	5	of	of	IN
cord-310748-ao29zx1u	126	6	recombination	recombination	NN
cord-310748-ao29zx1u	126	7	events	event	NNS
cord-310748-ao29zx1u	126	8	corresponded	correspond	VBD
cord-310748-ao29zx1u	126	9	to	to	IN
cord-310748-ao29zx1u	126	10	a	a	DT
cord-310748-ao29zx1u	126	11	hypervariable	hypervariable	JJ
cord-310748-ao29zx1u	126	12	region	region	NN
cord-310748-ao29zx1u	126	13	(	(	-LRB-
cord-310748-ao29zx1u	126	14	12	12	CD
cord-310748-ao29zx1u	126	15	,	,	,
cord-310748-ao29zx1u	126	16	22	22	CD
cord-310748-ao29zx1u	126	17	)	)	-RRB-
cord-310748-ao29zx1u	126	18	it	-PRON-	PRP
cord-310748-ao29zx1u	126	19	is	be	VBZ
cord-310748-ao29zx1u	126	20	logical	logical	JJ
cord-310748-ao29zx1u	126	21	to	to	TO
cord-310748-ao29zx1u	126	22	propose	propose	VB
cord-310748-ao29zx1u	126	23	that	that	IN
cord-310748-ao29zx1u	126	24	this	this	DT
cord-310748-ao29zx1u	126	25	protein	protein	NN
cord-310748-ao29zx1u	126	26	domain	domain	NN
cord-310748-ao29zx1u	126	27	is	be	VBZ
cord-310748-ao29zx1u	126	28	more	more	RBR
cord-310748-ao29zx1u	126	29	tolerant	tolerant	JJ
cord-310748-ao29zx1u	126	30	of	of	IN
cord-310748-ao29zx1u	126	31	structural	structural	JJ
cord-310748-ao29zx1u	126	32	modifications	modification	NNS
cord-310748-ao29zx1u	126	33	.	.	.
cord-310748-ao29zx1u	127	1	It	-PRON-	PRP
cord-310748-ao29zx1u	127	2	is	be	VBZ
cord-310748-ao29zx1u	127	3	interesting	interesting	JJ
cord-310748-ao29zx1u	127	4	that	that	IN
cord-310748-ao29zx1u	127	5	recombinant	recombinant	JJ
cord-310748-ao29zx1u	127	6	RNA	RNA	NNP
cord-310748-ao29zx1u	127	7	containing	contain	VBG
cord-310748-ao29zx1u	127	8	a	a	DT
cord-310748-ao29zx1u	127	9	deletion	deletion	NN
cord-310748-ao29zx1u	127	10	was	be	VBD
cord-310748-ao29zx1u	127	11	detected	detect	VBN
cord-310748-ao29zx1u	127	12	only	only	RB
cord-310748-ao29zx1u	127	13	in	in	IN
cord-310748-ao29zx1u	127	14	intracellular	intracellular	JJ
cord-310748-ao29zx1u	127	15	RNA	RNA	NNP
cord-310748-ao29zx1u	127	16	but	but	CC
cord-310748-ao29zx1u	127	17	not	not	RB
cord-310748-ao29zx1u	127	18	in	in	IN
cord-310748-ao29zx1u	127	19	RNA	RNA	NNP
cord-310748-ao29zx1u	127	20	isolated	isolate	VBN
cord-310748-ao29zx1u	127	21	from	from	IN
cord-310748-ao29zx1u	127	22	virions	virion	NNS
cord-310748-ao29zx1u	127	23	,	,	,
cord-310748-ao29zx1u	127	24	suggesting	suggest	VBG
cord-310748-ao29zx1u	127	25	that	that	IN
cord-310748-ao29zx1u	127	26	these	these	DT
cord-310748-ao29zx1u	127	27	recombinants	recombinant	NNS
cord-310748-ao29zx1u	127	28	could	could	MD
cord-310748-ao29zx1u	127	29	not	not	RB
cord-310748-ao29zx1u	127	30	replicate	replicate	VB
cord-310748-ao29zx1u	127	31	under	under	IN
cord-310748-ao29zx1u	127	32	the	the	DT
cord-310748-ao29zx1u	127	33	culture	culture	NN
cord-310748-ao29zx1u	127	34	conditions	condition	NNS
cord-310748-ao29zx1u	127	35	.	.	.
cord-310748-ao29zx1u	128	1	Also	also	RB
cord-310748-ao29zx1u	128	2	,	,	,
cord-310748-ao29zx1u	128	3	The	the	DT
cord-310748-ao29zx1u	128	4	brackets	bracket	NNS
cord-310748-ao29zx1u	128	5	indicate	indicate	VBP
cord-310748-ao29zx1u	128	6	the	the	DT
cord-310748-ao29zx1u	128	7	region	region	NN
cord-310748-ao29zx1u	128	8	in	in	IN
cord-310748-ao29zx1u	128	9	which	which	WDT
cord-310748-ao29zx1u	128	10	the	the	DT
cord-310748-ao29zx1u	128	11	crossovers	crossover	NNS
cord-310748-ao29zx1u	128	12	occurred	occur	VBD
cord-310748-ao29zx1u	128	13	.	.	.
cord-310748-ao29zx1u	129	1	Thick	thick	JJ
cord-310748-ao29zx1u	129	2	lines	line	NNS
cord-310748-ao29zx1u	129	3	underneath	underneath	IN
cord-310748-ao29zx1u	129	4	the	the	DT
cord-310748-ao29zx1u	129	5	sequences	sequence	NNS
cord-310748-ao29zx1u	129	6	represent	represent	VBP
cord-310748-ao29zx1u	129	7	JHM	JHM	NNP
cord-310748-ao29zx1u	129	8	-	-	HYPH
cord-310748-ao29zx1u	129	9	DL	dl	NN
cord-310748-ao29zx1u	129	10	-	-	HYPH
cord-310748-ao29zx1u	129	11	specific	specific	JJ
cord-310748-ao29zx1u	129	12	sequences	sequence	NNS
cord-310748-ao29zx1u	129	13	,	,	,
cord-310748-ao29zx1u	129	14	and	and	CC
cord-310748-ao29zx1u	129	15	thin	thin	JJ
cord-310748-ao29zx1u	129	16	lines	line	NNS
cord-310748-ao29zx1u	129	17	represent	represent	VBP
cord-310748-ao29zx1u	129	18	A59-specific	A59-specific	NNP
cord-310748-ao29zx1u	129	19	sequences	sequence	NNS
cord-310748-ao29zx1u	129	20	.	.	.
cord-310748-ao29zx1u	130	1	even	even	RB
cord-310748-ao29zx1u	130	2	at	at	IN
cord-310748-ao29zx1u	130	3	Passage	passage	NN
cord-310748-ao29zx1u	130	4	3	3	CD
cord-310748-ao29zx1u	130	5	,	,	,
cord-310748-ao29zx1u	130	6	approximately	approximately	RB
cord-310748-ao29zx1u	130	7	20	20	CD
cord-310748-ao29zx1u	130	8	%	%	NN
cord-310748-ao29zx1u	130	9	of	of	IN
cord-310748-ao29zx1u	130	10	the	the	DT
cord-310748-ao29zx1u	130	11	crossover	crossover	NN
cord-310748-ao29zx1u	130	12	sites	site	NNS
cord-310748-ao29zx1u	130	13	still	still	RB
cord-310748-ao29zx1u	130	14	fell	fall	VBD
cord-310748-ao29zx1u	130	15	outside	outside	IN
cord-310748-ao29zx1u	130	16	the	the	DT
cord-310748-ao29zx1u	130	17	nucleotide	nucleotide	JJ
cord-310748-ao29zx1u	130	18	1000-l	1000-l	NN
cord-310748-ao29zx1u	130	19	350	350	CD
cord-310748-ao29zx1u	130	20	region	region	NN
cord-310748-ao29zx1u	130	21	.	.	.
cord-310748-ao29zx1u	131	1	This	this	DT
cord-310748-ao29zx1u	131	2	was	be	VBD
cord-310748-ao29zx1u	131	3	to	to	TO
cord-310748-ao29zx1u	131	4	be	be	VB
cord-310748-ao29zx1u	131	5	expected	expect	VBN
cord-310748-ao29zx1u	131	6	since	since	IN
cord-310748-ao29zx1u	131	7	recombination	recombination	NN
cord-310748-ao29zx1u	131	8	could	could	MD
cord-310748-ao29zx1u	131	9	still	still	RB
cord-310748-ao29zx1u	131	10	occur	occur	VB
cord-310748-ao29zx1u	131	11	between	between	IN
cord-310748-ao29zx1u	131	12	the	the	DT
cord-310748-ao29zx1u	131	13	remaining	remain	VBG
cord-310748-ao29zx1u	131	14	parental	parental	JJ
cord-310748-ao29zx1u	131	15	A59	A59	NNP
cord-310748-ao29zx1u	131	16	and	and	CC
cord-310748-ao29zx1u	131	17	JHM	JHM	NNP
cord-310748-ao29zx1u	131	18	-	-	HYPH
cord-310748-ao29zx1u	131	19	DL	DL	NNP
cord-310748-ao29zx1u	131	20	RNA	RNA	NNP
cord-310748-ao29zx1u	131	21	upon	upon	IN
cord-310748-ao29zx1u	131	22	each	each	DT
cord-310748-ao29zx1u	131	23	reinfection	reinfection	NN
cord-310748-ao29zx1u	131	24	.	.	.
cord-310748-ao29zx1u	132	1	It	-PRON-	PRP
cord-310748-ao29zx1u	132	2	should	should	MD
cord-310748-ao29zx1u	132	3	be	be	VB
cord-310748-ao29zx1u	132	4	noted	note	VBN
cord-310748-ao29zx1u	132	5	that	that	IN
cord-310748-ao29zx1u	132	6	this	this	DT
cord-310748-ao29zx1u	132	7	study	study	NN
cord-310748-ao29zx1u	132	8	examined	examine	VBD
cord-310748-ao29zx1u	132	9	only	only	RB
cord-310748-ao29zx1u	132	10	a	a	DT
cord-310748-ao29zx1u	132	11	small	small	JJ
cord-310748-ao29zx1u	132	12	region	region	NN
cord-310748-ao29zx1u	132	13	of	of	IN
cord-310748-ao29zx1u	132	14	the	the	DT
cord-310748-ao29zx1u	132	15	MHV	MHV	NNP
cord-310748-ao29zx1u	132	16	genome	genome	NN
cord-310748-ao29zx1u	132	17	.	.	.
cord-310748-ao29zx1u	133	1	When	when	WRB
cord-310748-ao29zx1u	133	2	the	the	DT
cord-310748-ao29zx1u	133	3	entire	entire	JJ
cord-310748-ao29zx1u	133	4	MHV	MHV	NNP
cord-310748-ao29zx1u	133	5	RNA	RNA	NNP
cord-310748-ao29zx1u	133	6	is	be	VBZ
cord-310748-ao29zx1u	133	7	considered	consider	VBN
cord-310748-ao29zx1u	133	8	,	,	,
cord-310748-ao29zx1u	133	9	it	-PRON-	PRP
cord-310748-ao29zx1u	133	10	is	be	VBZ
cord-310748-ao29zx1u	133	11	possible	possible	JJ
cord-310748-ao29zx1u	133	12	that	that	IN
cord-310748-ao29zx1u	133	13	recombination	recombination	NN
cord-310748-ao29zx1u	133	14	may	may	MD
cord-310748-ao29zx1u	133	15	occur	occur	VB
cord-310748-ao29zx1u	133	16	at	at	IN
cord-310748-ao29zx1u	133	17	different	different	JJ
cord-310748-ao29zx1u	133	18	rates	rate	NNS
cord-310748-ao29zx1u	133	19	in	in	IN
cord-310748-ao29zx1u	133	20	different	different	JJ
cord-310748-ao29zx1u	133	21	regions	region	NNS
cord-310748-ao29zx1u	133	22	.	.	.
cord-310748-ao29zx1u	134	1	Nevertheless	nevertheless	RB
cord-310748-ao29zx1u	134	2	,	,	,
cord-310748-ao29zx1u	134	3	this	this	DT
cord-310748-ao29zx1u	134	4	study	study	NN
cord-310748-ao29zx1u	134	5	provided	provide	VBD
cord-310748-ao29zx1u	134	6	an	an	DT
cord-310748-ao29zx1u	134	7	interesting	interesting	JJ
cord-310748-ao29zx1u	134	8	implication	implication	NN
cord-310748-ao29zx1u	134	9	that	that	IN
cord-310748-ao29zx1u	134	10	the	the	DT
cord-310748-ao29zx1u	134	11	failure	failure	NN
cord-310748-ao29zx1u	134	12	to	to	TO
cord-310748-ao29zx1u	134	13	detect	detect	VB
cord-310748-ao29zx1u	134	14	homologous	homologous	JJ
cord-310748-ao29zx1u	134	15	RNA	RNA	NNP
cord-310748-ao29zx1u	134	16	recombination	recombination	NN
cord-310748-ao29zx1u	134	17	in	in	IN
cord-310748-ao29zx1u	134	18	other	other	JJ
cord-310748-ao29zx1u	134	19	RNAviruses	rnaviruse	NNS
cord-310748-ao29zx1u	134	20	may	may	MD
cord-310748-ao29zx1u	134	21	be	be	VB
cord-310748-ao29zx1u	134	22	due	due	JJ
cord-310748-ao29zx1u	134	23	to	to	IN
cord-310748-ao29zx1u	134	24	a	a	DT
cord-310748-ao29zx1u	134	25	stringent	stringent	JJ
cord-310748-ao29zx1u	134	26	structural	structural	JJ
cord-310748-ao29zx1u	134	27	requirement	requirement	NN
cord-310748-ao29zx1u	134	28	of	of	IN
cord-310748-ao29zx1u	134	29	the	the	DT
cord-310748-ao29zx1u	134	30	viral	viral	JJ
cord-310748-ao29zx1u	134	31	proteins	protein	NNS
cord-310748-ao29zx1u	134	32	such	such	JJ
cord-310748-ao29zx1u	134	33	that	that	IN
cord-310748-ao29zx1u	134	34	hybrid	hybrid	JJ
cord-310748-ao29zx1u	134	35	proteins	protein	NNS
cord-310748-ao29zx1u	134	36	have	have	VBP
cord-310748-ao29zx1u	134	37	an	an	DT
cord-310748-ao29zx1u	134	38	evolutionary	evolutionary	JJ
cord-310748-ao29zx1u	134	39	disadvantage	disadvantage	NN
cord-310748-ao29zx1u	134	40	.	.	.
cord-310748-ao29zx1u	135	1	This	this	DT
cord-310748-ao29zx1u	135	2	may	may	MD
cord-310748-ao29zx1u	135	3	explain	explain	VB
cord-310748-ao29zx1u	135	4	why	why	WRB
cord-310748-ao29zx1u	135	5	nonhomologous	nonhomologous	NNP
cord-310748-ao29zx1u	135	6	recombination	recombination	NN
cord-310748-ao29zx1u	135	7	(	(	-LRB-
cord-310748-ao29zx1u	135	8	as	as	IN
cord-310748-ao29zx1u	135	9	exemplified	exemplify	VBN
cord-310748-ao29zx1u	135	10	by	by	IN
cord-310748-ao29zx1u	135	11	DI	DI	NNP
cord-310748-ao29zx1u	135	12	RNA	RNA	NNP
cord-310748-ao29zx1u	135	13	generation	generation	NN
cord-310748-ao29zx1u	135	14	)	)	-RRB-
cord-310748-ao29zx1u	135	15	can	can	MD
cord-310748-ao29zx1u	135	16	be	be	VB
cord-310748-ao29zx1u	135	17	detected	detect	VBN
cord-310748-ao29zx1u	135	18	readily	readily	RB
cord-310748-ao29zx1u	135	19	,	,	,
cord-310748-ao29zx1u	135	20	whereas	whereas	IN
cord-310748-ao29zx1u	135	21	homologous	homologous	JJ
cord-310748-ao29zx1u	135	22	recombination	recombination	NN
cord-310748-ao29zx1u	135	23	has	have	VBZ
cord-310748-ao29zx1u	135	24	not	not	RB
cord-310748-ao29zx1u	135	25	been	be	VBN
cord-310748-ao29zx1u	135	26	demonstrated	demonstrate	VBN
cord-310748-ao29zx1u	135	27	for	for	IN
cord-310748-ao29zx1u	135	28	most	most	JJS
cord-310748-ao29zx1u	135	29	RNA	RNA	NNP
cord-310748-ao29zx1u	135	30	viruses	virus	NNS
cord-310748-ao29zx1u	135	31	.	.	.
cord-310748-ao29zx1u	136	1	In	in	IN
cord-310748-ao29zx1u	136	2	addition	addition	NN
cord-310748-ao29zx1u	136	3	,	,	,
cord-310748-ao29zx1u	136	4	it	-PRON-	PRP
cord-310748-ao29zx1u	136	5	explains	explain	VBZ
cord-310748-ao29zx1u	136	6	why	why	WRB
cord-310748-ao29zx1u	136	7	recombination	recombination	NN
cord-310748-ao29zx1u	136	8	events	event	NNS
cord-310748-ao29zx1u	136	9	have	have	VBP
cord-310748-ao29zx1u	136	10	not	not	RB
cord-310748-ao29zx1u	136	11	been	be	VBN
cord-310748-ao29zx1u	136	12	detected	detect	VBN
cord-310748-ao29zx1u	136	13	in	in	IN
cord-310748-ao29zx1u	136	14	the	the	DT
cord-310748-ao29zx1u	136	15	capsid	capsid	JJ
cord-310748-ao29zx1u	136	16	protein	protein	NN
cord-310748-ao29zx1u	136	17	region	region	NN
cord-310748-ao29zx1u	136	18	of	of	IN
cord-310748-ao29zx1u	136	19	FMDV	FMDV	NNP
cord-310748-ao29zx1u	136	20	(	(	-LRB-
cord-310748-ao29zx1u	136	21	1	1	CD
cord-310748-ao29zx1u	136	22	)	)	-RRB-
cord-310748-ao29zx1u	136	23	.	.	.
cord-310748-ao29zx1u	137	1	The	the	DT
cord-310748-ao29zx1u	137	2	approach	approach	NN
cord-310748-ao29zx1u	137	3	described	describe	VBN
cord-310748-ao29zx1u	137	4	in	in	IN
cord-310748-ao29zx1u	137	5	this	this	DT
cord-310748-ao29zx1u	137	6	report	report	NN
cord-310748-ao29zx1u	137	7	should	should	MD
cord-310748-ao29zx1u	137	8	provide	provide	VB
cord-310748-ao29zx1u	137	9	a	a	DT
cord-310748-ao29zx1u	137	10	useful	useful	JJ
cord-310748-ao29zx1u	137	11	tool	tool	NN
cord-310748-ao29zx1u	137	12	to	to	TO
cord-310748-ao29zx1u	137	13	study	study	VB
cord-310748-ao29zx1u	137	14	these	these	DT
cord-310748-ao29zx1u	137	15	possibilities	possibility	NNS
cord-310748-ao29zx1u	137	16	.	.	.
cord-310748-ao29zx1u	138	1	Proc	proc	VB
cord-310748-ao29zx1u	138	2	.	.	.
cord-310748-ao29zx1u	139	1	Natl	Natl	NNP
cord-310748-ao29zx1u	139	2	.	.	.
cord-310748-ao29zx1u	139	3	Acad	Acad	NNP
cord-310748-ao29zx1u	139	4	.	.	.
cord-310748-ao29zx1u	140	1	SC	SC	NNP
cord-310748-ao29zx1u	140	2	;	;	:
cord-310748-ao29zx1u	140	3	.	.	.
cord-310748-ao29zx1u	141	1	USA	USA	NNP
cord-310748-ao29zx1u	141	2	87	87	CD
cord-310748-ao29zx1u	141	3	Institute	Institute	NNP
cord-310748-ao29zx1u	141	4	.	.	.