id sid tid token lemma pos cord-324054-d71rj29o 1 1 key key JJ cord-324054-d71rj29o 2 1 : : : cord-324054-d71rj29o 2 2 cord-324054-d71rj29o cord-324054-d71rj29o NNP cord-324054-d71rj29o 2 3 authors author NNS cord-324054-d71rj29o 2 4 : : : cord-324054-d71rj29o 2 5 Zhang Zhang NNP cord-324054-d71rj29o 2 6 , , , cord-324054-d71rj29o 2 7 Xuming xuming NN cord-324054-d71rj29o 2 8 ; ; : cord-324054-d71rj29o 3 1 Kousoulas Kousoulas NNP cord-324054-d71rj29o 3 2 , , , cord-324054-d71rj29o 3 3 Konstantin Konstantin NNP cord-324054-d71rj29o 3 4 G. G. NNP cord-324054-d71rj29o 3 5 ; ; : cord-324054-d71rj29o 3 6 Storz Storz NNP cord-324054-d71rj29o 3 7 , , , cord-324054-d71rj29o 3 8 Johannes Johannes NNP cord-324054-d71rj29o 3 9 title title NN cord-324054-d71rj29o 3 10 : : : cord-324054-d71rj29o 3 11 The the DT cord-324054-d71rj29o 3 12 hemagglutinin hemagglutinin NN cord-324054-d71rj29o 3 13 / / SYM cord-324054-d71rj29o 3 14 esterase esterase NN cord-324054-d71rj29o 3 15 gene gene NN cord-324054-d71rj29o 3 16 of of IN cord-324054-d71rj29o 3 17 human human JJ cord-324054-d71rj29o 3 18 coronavirus coronavirus NN cord-324054-d71rj29o 3 19 strain strain VBP cord-324054-d71rj29o 3 20 OC43 OC43 NNP cord-324054-d71rj29o 3 21 : : : cord-324054-d71rj29o 4 1 Phylogenetic phylogenetic JJ cord-324054-d71rj29o 4 2 relationships relationship NNS cord-324054-d71rj29o 4 3 to to IN cord-324054-d71rj29o 4 4 bovine bovine JJ cord-324054-d71rj29o 4 5 and and CC cord-324054-d71rj29o 4 6 murine murine JJ cord-324054-d71rj29o 4 7 coronaviruses coronaviruse NNS cord-324054-d71rj29o 4 8 and and CC cord-324054-d71rj29o 4 9 influenza influenza NN cord-324054-d71rj29o 4 10 C c NN cord-324054-d71rj29o 4 11 virus virus NN cord-324054-d71rj29o 4 12 date date NN cord-324054-d71rj29o 4 13 : : : cord-324054-d71rj29o 4 14 1992 1992 CD cord-324054-d71rj29o 4 15 - - HYPH cord-324054-d71rj29o 4 16 01 01 CD cord-324054-d71rj29o 4 17 - - HYPH cord-324054-d71rj29o 4 18 31 31 CD cord-324054-d71rj29o 4 19 journal journal NN cord-324054-d71rj29o 4 20 : : : cord-324054-d71rj29o 5 1 Virology virology NN cord-324054-d71rj29o 5 2 DOI DOI NNP cord-324054-d71rj29o 5 3 : : : cord-324054-d71rj29o 5 4 10.1016/0042 10.1016/0042 CD cord-324054-d71rj29o 5 5 - - HYPH cord-324054-d71rj29o 5 6 6822(92)90089 6822(92)90089 CD cord-324054-d71rj29o 5 7 - - HYPH cord-324054-d71rj29o 5 8 8 8 CD cord-324054-d71rj29o 5 9 sha sha NN cord-324054-d71rj29o 5 10 : : : cord-324054-d71rj29o 6 1 f0383dfc986d198dd48125704827db59270605f0 f0383dfc986d198dd48125704827db59270605f0 NNP cord-324054-d71rj29o 6 2 doc_id doc_id NNP cord-324054-d71rj29o 6 3 : : : cord-324054-d71rj29o 6 4 324054 324054 CD cord-324054-d71rj29o 6 5 cord_uid cord_uid NN cord-324054-d71rj29o 6 6 : : : cord-324054-d71rj29o 7 1 d71rj29o d71rj29o NNP cord-324054-d71rj29o 7 2 Abstract Abstract NNP cord-324054-d71rj29o 7 3 The the DT cord-324054-d71rj29o 7 4 complete complete JJ cord-324054-d71rj29o 7 5 nucleotide nucleotide JJ cord-324054-d71rj29o 7 6 sequences sequence NNS cord-324054-d71rj29o 7 7 of of IN cord-324054-d71rj29o 7 8 the the DT cord-324054-d71rj29o 7 9 hemagglutinin hemagglutinin NN cord-324054-d71rj29o 7 10 / / SYM cord-324054-d71rj29o 7 11 esterase esterase NN cord-324054-d71rj29o 7 12 ( ( -LRB- cord-324054-d71rj29o 7 13 HE he NN cord-324054-d71rj29o 7 14 ) ) -RRB- cord-324054-d71rj29o 7 15 genes gene NNS cord-324054-d71rj29o 7 16 of of IN cord-324054-d71rj29o 7 17 human human JJ cord-324054-d71rj29o 7 18 coronavirus coronavirus NN cord-324054-d71rj29o 7 19 ( ( -LRB- cord-324054-d71rj29o 7 20 HCV HCV NNP cord-324054-d71rj29o 7 21 ) ) -RRB- cord-324054-d71rj29o 7 22 strain strain VBP cord-324054-d71rj29o 7 23 OC43 OC43 NNP cord-324054-d71rj29o 7 24 and and CC cord-324054-d71rj29o 7 25 bovine bovine JJ cord-324054-d71rj29o 7 26 respiratory respiratory JJ cord-324054-d71rj29o 7 27 coronavirus coronavirus NN cord-324054-d71rj29o 7 28 ( ( -LRB- cord-324054-d71rj29o 7 29 BRCV BRCV NNP cord-324054-d71rj29o 7 30 ) ) -RRB- cord-324054-d71rj29o 8 1 strain strain VB cord-324054-d71rj29o 8 2 G95 G95 NNP cord-324054-d71rj29o 8 3 were be VBD cord-324054-d71rj29o 8 4 determined determine VBN cord-324054-d71rj29o 8 5 from from IN cord-324054-d71rj29o 8 6 single single RB cord-324054-d71rj29o 8 7 - - HYPH cord-324054-d71rj29o 8 8 stranded strand VBN cord-324054-d71rj29o 8 9 cDNA cdna NN cord-324054-d71rj29o 8 10 fragments fragment NNS cord-324054-d71rj29o 8 11 generated generate VBN cord-324054-d71rj29o 8 12 by by IN cord-324054-d71rj29o 8 13 reverse reverse JJ cord-324054-d71rj29o 8 14 transcription transcription NN cord-324054-d71rj29o 8 15 of of IN cord-324054-d71rj29o 8 16 virus virus NN cord-324054-d71rj29o 8 17 - - HYPH cord-324054-d71rj29o 8 18 specific specific JJ cord-324054-d71rj29o 8 19 mRNAs mrna NNS cord-324054-d71rj29o 8 20 and and CC cord-324054-d71rj29o 8 21 amplified amplify VBN cord-324054-d71rj29o 8 22 by by IN cord-324054-d71rj29o 8 23 polymerase polymerase NN cord-324054-d71rj29o 8 24 chain chain NN cord-324054-d71rj29o 8 25 reaction reaction NN cord-324054-d71rj29o 8 26 . . . cord-324054-d71rj29o 9 1 An an DT cord-324054-d71rj29o 9 2 open open JJ cord-324054-d71rj29o 9 3 reading reading NN cord-324054-d71rj29o 9 4 frame frame NN cord-324054-d71rj29o 9 5 of of IN cord-324054-d71rj29o 9 6 1272 1272 CD cord-324054-d71rj29o 9 7 nucleotides nucleotide NNS cord-324054-d71rj29o 9 8 was be VBD cord-324054-d71rj29o 9 9 identified identify VBN cord-324054-d71rj29o 9 10 as as IN cord-324054-d71rj29o 9 11 the the DT cord-324054-d71rj29o 9 12 putative putative JJ cord-324054-d71rj29o 9 13 HE HE NNP cord-324054-d71rj29o 9 14 gene gene NN cord-324054-d71rj29o 9 15 by by IN cord-324054-d71rj29o 9 16 homology homology NN cord-324054-d71rj29o 9 17 to to IN cord-324054-d71rj29o 9 18 the the DT cord-324054-d71rj29o 9 19 bovine bovine JJ cord-324054-d71rj29o 9 20 coronavirus coronavirus NN cord-324054-d71rj29o 9 21 HE HE NNP cord-324054-d71rj29o 9 22 gene gene NN cord-324054-d71rj29o 9 23 . . . cord-324054-d71rj29o 10 1 This this DT cord-324054-d71rj29o 10 2 open open JJ cord-324054-d71rj29o 10 3 reading reading NN cord-324054-d71rj29o 10 4 frame frame NN cord-324054-d71rj29o 10 5 encodes encode VBZ cord-324054-d71rj29o 10 6 a a DT cord-324054-d71rj29o 10 7 protein protein NN cord-324054-d71rj29o 10 8 of of IN cord-324054-d71rj29o 10 9 424 424 CD cord-324054-d71rj29o 10 10 amino amino JJ cord-324054-d71rj29o 10 11 acids acid NNS cord-324054-d71rj29o 10 12 with with IN cord-324054-d71rj29o 10 13 an an DT cord-324054-d71rj29o 10 14 estimated estimate VBN cord-324054-d71rj29o 10 15 molecular molecular JJ cord-324054-d71rj29o 10 16 weight weight NN cord-324054-d71rj29o 10 17 of of IN cord-324054-d71rj29o 10 18 47.7 47.7 CD cord-324054-d71rj29o 10 19 kDa kDa NNS cord-324054-d71rj29o 10 20 . . . cord-324054-d71rj29o 11 1 Ten ten CD cord-324054-d71rj29o 11 2 potential potential JJ cord-324054-d71rj29o 11 3 N n CD cord-324054-d71rj29o 11 4 - - HYPH cord-324054-d71rj29o 11 5 linked link VBN cord-324054-d71rj29o 11 6 glycosylation glycosylation NN cord-324054-d71rj29o 11 7 sites site NNS cord-324054-d71rj29o 11 8 were be VBD cord-324054-d71rj29o 11 9 predicted predict VBN cord-324054-d71rj29o 11 10 in in IN cord-324054-d71rj29o 11 11 the the DT cord-324054-d71rj29o 11 12 HE HE NNP cord-324054-d71rj29o 11 13 protein protein NN cord-324054-d71rj29o 11 14 of of IN cord-324054-d71rj29o 11 15 HCV HCV NNP cord-324054-d71rj29o 11 16 - - HYPH cord-324054-d71rj29o 11 17 OC43 OC43 NNP cord-324054-d71rj29o 11 18 while while IN cord-324054-d71rj29o 11 19 nine nine CD cord-324054-d71rj29o 11 20 of of IN cord-324054-d71rj29o 11 21 them -PRON- PRP cord-324054-d71rj29o 11 22 were be VBD cord-324054-d71rj29o 11 23 present present JJ cord-324054-d71rj29o 11 24 in in IN cord-324054-d71rj29o 11 25 BRCV BRCV NNP cord-324054-d71rj29o 11 26 - - HYPH cord-324054-d71rj29o 11 27 G95 G95 NNP cord-324054-d71rj29o 11 28 . . . cord-324054-d71rj29o 12 1 Fourteen fourteen CD cord-324054-d71rj29o 12 2 cysteine cysteine NN cord-324054-d71rj29o 12 3 residues residue NNS cord-324054-d71rj29o 12 4 were be VBD cord-324054-d71rj29o 12 5 conserved conserve VBN cord-324054-d71rj29o 12 6 in in IN cord-324054-d71rj29o 12 7 the the DT cord-324054-d71rj29o 12 8 HE HE NNP cord-324054-d71rj29o 12 9 proteins protein NNS cord-324054-d71rj29o 12 10 of of IN cord-324054-d71rj29o 12 11 both both DT cord-324054-d71rj29o 12 12 viruses virus NNS cord-324054-d71rj29o 12 13 . . . cord-324054-d71rj29o 13 1 Two two CD cord-324054-d71rj29o 13 2 hydrophobic hydrophobic JJ cord-324054-d71rj29o 13 3 sequences sequence NNS cord-324054-d71rj29o 13 4 at at IN cord-324054-d71rj29o 13 5 the the DT cord-324054-d71rj29o 13 6 N n CD cord-324054-d71rj29o 13 7 - - HYPH cord-324054-d71rj29o 13 8 terminus terminus NN cord-324054-d71rj29o 13 9 and and CC cord-324054-d71rj29o 13 10 the the DT cord-324054-d71rj29o 13 11 C C NNP cord-324054-d71rj29o 13 12 - - HYPH cord-324054-d71rj29o 13 13 terminus terminus NN cord-324054-d71rj29o 13 14 may may MD cord-324054-d71rj29o 13 15 serve serve VB cord-324054-d71rj29o 13 16 as as IN cord-324054-d71rj29o 13 17 signal signal NN cord-324054-d71rj29o 13 18 peptide peptide NN cord-324054-d71rj29o 13 19 and and CC cord-324054-d71rj29o 13 20 transmembrane transmembrane NN cord-324054-d71rj29o 13 21 anchoring anchoring NN cord-324054-d71rj29o 13 22 domain domain NN cord-324054-d71rj29o 13 23 , , , cord-324054-d71rj29o 13 24 respectively respectively RB cord-324054-d71rj29o 13 25 . . . cord-324054-d71rj29o 14 1 The the DT cord-324054-d71rj29o 14 2 predicted predict VBN cord-324054-d71rj29o 14 3 HE HE NNP cord-324054-d71rj29o 14 4 protein protein NN cord-324054-d71rj29o 14 5 of of IN cord-324054-d71rj29o 14 6 HCV HCV NNP cord-324054-d71rj29o 14 7 - - HYPH cord-324054-d71rj29o 14 8 OC43 OC43 NNP cord-324054-d71rj29o 14 9 was be VBD cord-324054-d71rj29o 14 10 95 95 CD cord-324054-d71rj29o 14 11 % % NN cord-324054-d71rj29o 14 12 identical identical JJ cord-324054-d71rj29o 14 13 to to IN cord-324054-d71rj29o 14 14 the the DT cord-324054-d71rj29o 14 15 HEs he NNS cord-324054-d71rj29o 14 16 of of IN cord-324054-d71rj29o 14 17 BRCV BRCV NNP cord-324054-d71rj29o 14 18 - - HYPH cord-324054-d71rj29o 14 19 G95 G95 NNP cord-324054-d71rj29o 14 20 and and CC cord-324054-d71rj29o 14 21 other other JJ cord-324054-d71rj29o 14 22 bovine bovine JJ cord-324054-d71rj29o 14 23 coronaviruses coronaviruse NNS cord-324054-d71rj29o 14 24 , , , cord-324054-d71rj29o 14 25 and and CC cord-324054-d71rj29o 14 26 60 60 CD cord-324054-d71rj29o 14 27 % % NN cord-324054-d71rj29o 14 28 identical identical JJ cord-324054-d71rj29o 14 29 to to IN cord-324054-d71rj29o 14 30 the the DT cord-324054-d71rj29o 14 31 HEs HEs NNPS cord-324054-d71rj29o 14 32 of of IN cord-324054-d71rj29o 14 33 mouse mouse NN cord-324054-d71rj29o 14 34 hepatitis hepatitis NN cord-324054-d71rj29o 14 35 viruses virus NNS cord-324054-d71rj29o 14 36 . . . cord-324054-d71rj29o 15 1 Phylogenetic phylogenetic JJ cord-324054-d71rj29o 15 2 analysis analysis NN cord-324054-d71rj29o 15 3 suggests suggest VBZ cord-324054-d71rj29o 15 4 that that IN cord-324054-d71rj29o 15 5 the the DT cord-324054-d71rj29o 15 6 HE HE NNP cord-324054-d71rj29o 15 7 genes gene NNS cord-324054-d71rj29o 15 8 of of IN cord-324054-d71rj29o 15 9 coronaviruses coronaviruse NNS cord-324054-d71rj29o 15 10 and and CC cord-324054-d71rj29o 15 11 influenza influenza NN cord-324054-d71rj29o 15 12 C c NN cord-324054-d71rj29o 15 13 virus virus NN cord-324054-d71rj29o 15 14 have have VBP cord-324054-d71rj29o 15 15 a a DT cord-324054-d71rj29o 15 16 common common JJ cord-324054-d71rj29o 15 17 ancestral ancestral JJ cord-324054-d71rj29o 15 18 origin origin NN cord-324054-d71rj29o 15 19 , , , cord-324054-d71rj29o 15 20 and and CC cord-324054-d71rj29o 15 21 that that IN cord-324054-d71rj29o 15 22 bovine bovine JJ cord-324054-d71rj29o 15 23 coronaviruses coronaviruse NNS cord-324054-d71rj29o 15 24 and and CC cord-324054-d71rj29o 15 25 HCV HCV NNP cord-324054-d71rj29o 15 26 - - HYPH cord-324054-d71rj29o 15 27 OC43 OC43 NNP cord-324054-d71rj29o 15 28 are be VBP cord-324054-d71rj29o 15 29 closely closely RB cord-324054-d71rj29o 15 30 related relate VBN cord-324054-d71rj29o 15 31 . . . cord-324054-d71rj29o 16 1 Coronaviruses coronaviruse NNS cord-324054-d71rj29o 16 2 possess possess VBP cord-324054-d71rj29o 16 3 a a DT cord-324054-d71rj29o 16 4 single single RB cord-324054-d71rj29o 16 5 - - HYPH cord-324054-d71rj29o 16 6 stranded stranded JJ cord-324054-d71rj29o 16 7 , , , cord-324054-d71rj29o 16 8 nonsegmented nonsegmente VBD cord-324054-d71rj29o 16 9 RNA RNA NNP cord-324054-d71rj29o 16 10 genome genome NN cord-324054-d71rj29o 16 11 of of IN cord-324054-d71rj29o 16 12 positive positive JJ cord-324054-d71rj29o 16 13 polarity polarity NN cord-324054-d71rj29o 16 14 ( ( -LRB- cord-324054-d71rj29o 16 15 1 1 CD cord-324054-d71rj29o 16 16 , , , cord-324054-d71rj29o 16 17 2 2 CD cord-324054-d71rj29o 16 18 ) ) -RRB- cord-324054-d71rj29o 16 19 and and CC cord-324054-d71rj29o 16 20 are be VBP cord-324054-d71rj29o 16 21 associated associate VBN cord-324054-d71rj29o 16 22 with with IN cord-324054-d71rj29o 16 23 a a DT cord-324054-d71rj29o 16 24 variety variety NN cord-324054-d71rj29o 16 25 of of IN cord-324054-d71rj29o 16 26 diseases disease NNS cord-324054-d71rj29o 16 27 in in IN cord-324054-d71rj29o 16 28 man man NN cord-324054-d71rj29o 16 29 and and CC cord-324054-d71rj29o 16 30 animals animal NNS cord-324054-d71rj29o 16 31 ( ( -LRB- cord-324054-d71rj29o 16 32 3 3 CD cord-324054-d71rj29o 16 33 - - SYM cord-324054-d71rj29o 16 34 5 5 CD cord-324054-d71rj29o 16 35 ) ) -RRB- cord-324054-d71rj29o 16 36 . . . cord-324054-d71rj29o 17 1 Coronaviruses coronaviruse NNS cord-324054-d71rj29o 17 2 are be VBP cord-324054-d71rj29o 17 3 divided divide VBN cord-324054-d71rj29o 17 4 into into IN cord-324054-d71rj29o 17 5 two two CD cord-324054-d71rj29o 17 6 major major JJ cord-324054-d71rj29o 17 7 antigenic antigenic JJ cord-324054-d71rj29o 17 8 groups group NNS cord-324054-d71rj29o 17 9 . . . cord-324054-d71rj29o 18 1 The the DT cord-324054-d71rj29o 18 2 first first JJ cord-324054-d71rj29o 18 3 group group NN cord-324054-d71rj29o 18 4 includes include VBZ cord-324054-d71rj29o 18 5 human human JJ cord-324054-d71rj29o 18 6 coronavirus coronavirus NN cord-324054-d71rj29o 18 7 strain strain VB cord-324054-d71rj29o 18 8 OC43 OC43 NNP cord-324054-d71rj29o 18 9 ( ( -LRB- cord-324054-d71rj29o 18 10 HCV HCV NNP cord-324054-d71rj29o 18 11 - - HYPH cord-324054-d71rj29o 18 12 OC43 OC43 NNP cord-324054-d71rj29o 18 13 ) ) -RRB- cord-324054-d71rj29o 18 14 , , , cord-324054-d71rj29o 18 15 bovine bovine JJ cord-324054-d71rj29o 18 16 coronavirus coronavirus NN cord-324054-d71rj29o 18 17 ( ( -LRB- cord-324054-d71rj29o 18 18 BCV BCV NNP cord-324054-d71rj29o 18 19 ) ) -RRB- cord-324054-d71rj29o 18 20 , , , cord-324054-d71rj29o 18 21 mouse mouse NNP cord-324054-d71rj29o 18 22 hepatitis hepatitis NN cord-324054-d71rj29o 18 23 virus virus NN cord-324054-d71rj29o 18 24 ( ( -LRB- cord-324054-d71rj29o 18 25 MHV MHV NNP cord-324054-d71rj29o 18 26 ) ) -RRB- cord-324054-d71rj29o 18 27 , , , cord-324054-d71rj29o 18 28 and and CC cord-324054-d71rj29o 18 29 hemagglutinating hemagglutinate VBG cord-324054-d71rj29o 18 30 encephalomyelitis encephalomyelitis NN cord-324054-d71rj29o 18 31 virus virus NN cord-324054-d71rj29o 18 32 of of IN cord-324054-d71rj29o 18 33 swine swine NN cord-324054-d71rj29o 18 34 ( ( -LRB- cord-324054-d71rj29o 18 35 HEV HEV NNP cord-324054-d71rj29o 18 36 ) ) -RRB- cord-324054-d71rj29o 18 37 ( ( -LRB- cord-324054-d71rj29o 18 38 2 2 CD cord-324054-d71rj29o 18 39 , , , cord-324054-d71rj29o 18 40 5 5 CD cord-324054-d71rj29o 18 41 ) ) -RRB- cord-324054-d71rj29o 18 42 . . . cord-324054-d71rj29o 19 1 HCV HCV NNP cord-324054-d71rj29o 19 2 - - HYPH cord-324054-d71rj29o 19 3 OC43 OC43 NNP cord-324054-d71rj29o 19 4 causes cause VBZ cord-324054-d71rj29o 19 5 respiratory respiratory JJ cord-324054-d71rj29o 19 6 infection infection NN cord-324054-d71rj29o 19 7 of of IN cord-324054-d71rj29o 19 8 man man NN cord-324054-d71rj29o 19 9 similar similar JJ cord-324054-d71rj29o 19 10 to to IN cord-324054-d71rj29o 19 11 those those DT cord-324054-d71rj29o 19 12 of of IN cord-324054-d71rj29o 19 13 influenza influenza NN cord-324054-d71rj29o 19 14 viruses virus NNS cord-324054-d71rj29o 19 15 ( ( -LRB- cord-324054-d71rj29o 19 16 6 6 CD cord-324054-d71rj29o 19 17 ) ) -RRB- cord-324054-d71rj29o 19 18 . . . cord-324054-d71rj29o 20 1 BCV BCV NNP cord-324054-d71rj29o 20 2 causes cause VBZ cord-324054-d71rj29o 20 3 enteritis enteritis NN cord-324054-d71rj29o 20 4 of of IN cord-324054-d71rj29o 20 5 newborn newborn JJ cord-324054-d71rj29o 20 6 calves calf NNS cord-324054-d71rj29o 20 7 and and CC cord-324054-d71rj29o 20 8 is be VBZ cord-324054-d71rj29o 20 9 also also RB cord-324054-d71rj29o 20 10 considered consider VBN cord-324054-d71rj29o 20 11 to to TO cord-324054-d71rj29o 20 12 be be VB cord-324054-d71rj29o 20 13 an an DT cord-324054-d71rj29o 20 14 etiological etiological JJ cord-324054-d71rj29o 20 15 factor factor NN cord-324054-d71rj29o 20 16 of of IN cord-324054-d71rj29o 20 17 respiratory respiratory JJ cord-324054-d71rj29o 20 18 diseases disease NNS cord-324054-d71rj29o 20 19 of of IN cord-324054-d71rj29o 20 20 calves calf NNS cord-324054-d71rj29o 20 21 ( ( -LRB- cord-324054-d71rj29o 20 22 7 7 CD cord-324054-d71rj29o 20 23 , , , cord-324054-d71rj29o 20 24 8) 8) NN cord-324054-d71rj29o 20 25 . . . cord-324054-d71rj29o 21 1 MHV MHV NNP cord-324054-d71rj29o 21 2 can can MD cord-324054-d71rj29o 21 3 infect infect VB cord-324054-d71rj29o 21 4 different different JJ cord-324054-d71rj29o 21 5 organs organ NNS cord-324054-d71rj29o 21 6 , , , cord-324054-d71rj29o 21 7 causing cause VBG cord-324054-d71rj29o 21 8 enteric enteric JJ cord-324054-d71rj29o 21 9 , , , cord-324054-d71rj29o 21 10 respiratory respiratory JJ cord-324054-d71rj29o 21 11 , , , cord-324054-d71rj29o 21 12 and and CC cord-324054-d71rj29o 21 13 neurological neurological JJ cord-324054-d71rj29o 21 14 diseases disease NNS cord-324054-d71rj29o 21 15 ( ( -LRB- cord-324054-d71rj29o 21 16 5 5 CD cord-324054-d71rj29o 21 17 , , , cord-324054-d71rj29o 21 18 9 9 CD cord-324054-d71rj29o 21 19 ) ) -RRB- cord-324054-d71rj29o 21 20 . . . cord-324054-d71rj29o 22 1 A a DT cord-324054-d71rj29o 22 2 unique unique JJ cord-324054-d71rj29o 22 3 property property NN cord-324054-d71rj29o 22 4 of of IN cord-324054-d71rj29o 22 5 coronaviruses coronaviruse NNS cord-324054-d71rj29o 22 6 within within IN cord-324054-d71rj29o 22 7 this this DT cord-324054-d71rj29o 22 8 antigenic antigenic JJ cord-324054-d71rj29o 22 9 cluster cluster NN cord-324054-d71rj29o 22 10 is be VBZ cord-324054-d71rj29o 22 11 the the DT cord-324054-d71rj29o 22 12 presence presence NN cord-324054-d71rj29o 22 13 of of IN cord-324054-d71rj29o 22 14 the the DT cord-324054-d71rj29o 22 15 hemagglutinin hemagglutinin NN cord-324054-d71rj29o 22 16 / / SYM cord-324054-d71rj29o 22 17 esterase esterase NN cord-324054-d71rj29o 22 18 ( ( -LRB- cord-324054-d71rj29o 22 19 HE he NN cord-324054-d71rj29o 22 20 ) ) -RRB- cord-324054-d71rj29o 22 21 gene gene NN cord-324054-d71rj29o 22 22 . . . cord-324054-d71rj29o 23 1 The the DT cord-324054-d71rj29o 23 2 genome genome NN cord-324054-d71rj29o 23 3 of of IN cord-324054-d71rj29o 23 4 MHV MHV NNP cord-324054-d71rj29o 23 5 - - HYPH cord-324054-d71rj29o 23 6 A59 A59 NNP cord-324054-d71rj29o 23 7 contains contain VBZ cord-324054-d71rj29o 23 8 an an DT cord-324054-d71rj29o 23 9 open open JJ cord-324054-d71rj29o 23 10 reading reading NN cord-324054-d71rj29o 23 11 frame frame NN cord-324054-d71rj29o 23 12 ( ( -LRB- cord-324054-d71rj29o 23 13 ORF ORF NNP cord-324054-d71rj29o 23 14 ) ) -RRB- cord-324054-d71rj29o 23 15 , , , cord-324054-d71rj29o 23 16 which which WDT cord-324054-d71rj29o 23 17 may may MD cord-324054-d71rj29o 23 18 code code VB cord-324054-d71rj29o 23 19 for for IN cord-324054-d71rj29o 23 20 an an DT cord-324054-d71rj29o 23 21 HE HE NNP cord-324054-d71rj29o 23 22 protein protein NN cord-324054-d71rj29o 23 23 . . . cord-324054-d71rj29o 24 1 However however RB cord-324054-d71rj29o 24 2 , , , cord-324054-d71rj29o 24 3 the the DT cord-324054-d71rj29o 24 4 HE HE NNP cord-324054-d71rj29o 24 5 is be VBZ cord-324054-d71rj29o 24 6 not not RB cord-324054-d71rj29o 24 7 expressed express VBN cord-324054-d71rj29o 24 8 in in IN cord-324054-d71rj29o 24 9 infected infected JJ cord-324054-d71rj29o 24 10 cells cell NNS cord-324054-d71rj29o 24 11 ( ( -LRB- cord-324054-d71rj29o 24 12 10 10 CD cord-324054-d71rj29o 24 13 , , , cord-324054-d71rj29o 24 14 11 11 CD cord-324054-d71rj29o 24 15 , , , cord-324054-d71rj29o 24 16 23 23 CD cord-324054-d71rj29o 24 17 binding binding NN cord-324054-d71rj29o 24 18 ) ) -RRB- cord-324054-d71rj29o 24 19 and and CC cord-324054-d71rj29o 24 20 acetylesterase acetylesterase NN cord-324054-d71rj29o 24 21 ( ( -LRB- cord-324054-d71rj29o 24 22 receptor receptor NN cord-324054-d71rj29o 24 23 - - HYPH cord-324054-d71rj29o 24 24 destroying destroy VBG cord-324054-d71rj29o 24 25 ) ) -RRB- cord-324054-d71rj29o 24 26 activities activity NNS cord-324054-d71rj29o 24 27 similar similar JJ cord-324054-d71rj29o 24 28 to to IN cord-324054-d71rj29o 24 29 the the DT cord-324054-d71rj29o 24 30 HE HE NNP cord-324054-d71rj29o 24 31 ( ( -LRB- cord-324054-d71rj29o 24 32 or or CC cord-324054-d71rj29o 24 33 HEF HEF NNP cord-324054-d71rj29o 24 34 ) ) -RRB- cord-324054-d71rj29o 24 35 glycoprotein glycoprotein NN cord-324054-d71rj29o 24 36 of of IN cord-324054-d71rj29o 24 37 influenza influenza NN cord-324054-d71rj29o 24 38 C c NN cord-324054-d71rj29o 24 39 virus virus NN cord-324054-d71rj29o 24 40 ( ( -LRB- cord-324054-d71rj29o 24 41 ICV ICV NNP cord-324054-d71rj29o 24 42 ) ) -RRB- cord-324054-d71rj29o 24 43 ( ( -LRB- cord-324054-d71rj29o 24 44 12 12 CD cord-324054-d71rj29o 24 45 ) ) -RRB- cord-324054-d71rj29o 24 46 ( ( -LRB- cord-324054-d71rj29o 24 47 13 13 CD cord-324054-d71rj29o 24 48 ) ) -RRB- cord-324054-d71rj29o 25 1 ( ( -LRB- cord-324054-d71rj29o 25 2 14 14 CD cord-324054-d71rj29o 25 3 ) ) -RRB- cord-324054-d71rj29o 26 1 ( ( -LRB- cord-324054-d71rj29o 26 2 15 15 CD cord-324054-d71rj29o 26 3 ) ) -RRB- cord-324054-d71rj29o 26 4 ( ( -LRB- cord-324054-d71rj29o 26 5 16 16 CD cord-324054-d71rj29o 26 6 ) ) -RRB- cord-324054-d71rj29o 26 7 ( ( -LRB- cord-324054-d71rj29o 26 8 17 17 CD cord-324054-d71rj29o 26 9 ) ) -RRB- cord-324054-d71rj29o 26 10 ( ( -LRB- cord-324054-d71rj29o 26 11 18 18 CD cord-324054-d71rj29o 26 12 ) ) -RRB- cord-324054-d71rj29o 26 13 ( ( -LRB- cord-324054-d71rj29o 26 14 19 19 CD cord-324054-d71rj29o 26 15 ) ) -RRB- cord-324054-d71rj29o 26 16 ( ( -LRB- cord-324054-d71rj29o 26 17 20 20 CD cord-324054-d71rj29o 26 18 ) ) -RRB- cord-324054-d71rj29o 26 19 . . . cord-324054-d71rj29o 27 1 It -PRON- PRP cord-324054-d71rj29o 27 2 was be VBD cord-324054-d71rj29o 27 3 shown show VBN cord-324054-d71rj29o 27 4 that that IN cord-324054-d71rj29o 27 5 the the DT cord-324054-d71rj29o 27 6 HE HE NNP cord-324054-d71rj29o 27 7 glycoprotein glycoprotein NN cord-324054-d71rj29o 27 8 of of IN cord-324054-d71rj29o 27 9 BCV BCV NNP cord-324054-d71rj29o 27 10 strain strain VBP cord-324054-d71rj29o 27 11 Quebec Quebec NNP cord-324054-d71rj29o 27 12 induces induce VBZ cord-324054-d71rj29o 27 13 neutralizing neutralize VBG cord-324054-d71rj29o 27 14 antibodies antibody NNS cord-324054-d71rj29o 27 15 both both DT cord-324054-d71rj29o 27 16 in in IN cord-324054-d71rj29o 27 17 vitro vitro FW cord-324054-d71rj29o 27 18 and and CC cord-324054-d71rj29o 27 19 in in IN cord-324054-d71rj29o 27 20 viva viva NNP cord-324054-d71rj29o 27 21 and and CC cord-324054-d71rj29o 27 22 thus thus RB cord-324054-d71rj29o 27 23 , , , cord-324054-d71rj29o 27 24 is be VBZ cord-324054-d71rj29o 27 25 important important JJ cord-324054-d71rj29o 27 26 in in IN cord-324054-d71rj29o 27 27 viral viral JJ cord-324054-d71rj29o 27 28 infectivity infectivity NN cord-324054-d71rj29o 27 29 ( ( -LRB- cord-324054-d71rj29o 27 30 21 21 CD cord-324054-d71rj29o 27 31 , , , cord-324054-d71rj29o 27 32 22 22 CD cord-324054-d71rj29o 27 33 ) ) -RRB- cord-324054-d71rj29o 27 34 . . . cord-324054-d71rj29o 28 1 It -PRON- PRP cord-324054-d71rj29o 28 2 is be VBZ cord-324054-d71rj29o 28 3 evidently evidently RB cord-324054-d71rj29o 28 4 not not RB cord-324054-d71rj29o 28 5 required require VBN cord-324054-d71rj29o 28 6 for for IN cord-324054-d71rj29o 28 7 viral viral JJ cord-324054-d71rj29o 28 8 infectivity infectivity NN cord-324054-d71rj29o 28 9 in in IN cord-324054-d71rj29o 28 10 MHV MHV NNP cord-324054-d71rj29o 28 11 - - HYPH cord-324054-d71rj29o 28 12 A59 A59 NNP cord-324054-d71rj29o 28 13 and and CC cord-324054-d71rj29o 28 14 MHV MHV NNP cord-324054-d71rj29o 28 15 - - HYPH cord-324054-d71rj29o 28 16 JHM JHM NNP cord-324054-d71rj29o 28 17 ( ( -LRB- cord-324054-d71rj29o 28 18 11 11 CD cord-324054-d71rj29o 28 19 ) ) -RRB- cord-324054-d71rj29o 28 20 . . . cord-324054-d71rj29o 29 1 The the DT cord-324054-d71rj29o 29 2 role role NN cord-324054-d71rj29o 29 3 of of IN cord-324054-d71rj29o 29 4 the the DT cord-324054-d71rj29o 29 5 HE HE NNP cord-324054-d71rj29o 29 6 gene gene NN cord-324054-d71rj29o 29 7 and and CC cord-324054-d71rj29o 29 8 its -PRON- PRP$ cord-324054-d71rj29o 29 9 protein protein NN cord-324054-d71rj29o 29 10 in in IN cord-324054-d71rj29o 29 11 coronavirus coronavirus NN cord-324054-d71rj29o 29 12 evolution evolution NN cord-324054-d71rj29o 29 13 , , , cord-324054-d71rj29o 29 14 replication replication NN cord-324054-d71rj29o 29 15 , , , cord-324054-d71rj29o 29 16 and and CC cord-324054-d71rj29o 29 17 pathogenesis pathogenesis NN cord-324054-d71rj29o 29 18 remains remain VBZ cord-324054-d71rj29o 29 19 unclear unclear JJ cord-324054-d71rj29o 29 20 . . . cord-324054-d71rj29o 30 1 The the DT cord-324054-d71rj29o 30 2 exact exact JJ cord-324054-d71rj29o 30 3 genomic genomic JJ cord-324054-d71rj29o 30 4 organization organization NN cord-324054-d71rj29o 30 5 of of IN cord-324054-d71rj29o 30 6 HCV HCV NNP cord-324054-d71rj29o 30 7 - - HYPH cord-324054-d71rj29o 30 8 OC43 OC43 NNP cord-324054-d71rj29o 30 9 is be VBZ cord-324054-d71rj29o 30 10 not not RB cord-324054-d71rj29o 30 11 known know VBN cord-324054-d71rj29o 30 12 . . . cord-324054-d71rj29o 31 1 Antigenic antigenic JJ cord-324054-d71rj29o 31 2 and and CC cord-324054-d71rj29o 31 3 nucleic nucleic JJ cord-324054-d71rj29o 31 4 acid acid NN cord-324054-d71rj29o 31 5 hybridization hybridization NN cord-324054-d71rj29o 31 6 studies study NNS cord-324054-d71rj29o 31 7 indicate indicate VBP cord-324054-d71rj29o 31 8 that that IN cord-324054-d71rj29o 31 9 the the DT cord-324054-d71rj29o 31 10 HCV HCV NNP cord-324054-d71rj29o 31 11 - - HYPH cord-324054-d71rj29o 31 12 OC43 OC43 NNP cord-324054-d71rj29o 31 13 is be VBZ cord-324054-d71rj29o 31 14 closely closely RB cord-324054-d71rj29o 31 15 related related JJ cord-324054-d71rj29o 31 16 to to IN cord-324054-d71rj29o 31 17 BCV BCV NNP cord-324054-d71rj29o 31 18 ( ( -LRB- cord-324054-d71rj29o 31 19 23 23 CD cord-324054-d71rj29o 31 20 - - SYM cord-324054-d71rj29o 31 21 25 25 CD cord-324054-d71rj29o 31 22 ) ) -RRB- cord-324054-d71rj29o 31 23 . . . cord-324054-d71rj29o 32 1 By by IN cord-324054-d71rj29o 32 2 analogy analogy NN cord-324054-d71rj29o 32 3 to to IN cord-324054-d71rj29o 32 4 BCV BCV NNP cord-324054-d71rj29o 32 5 , , , cord-324054-d71rj29o 32 6 the the DT cord-324054-d71rj29o 32 7 order order NN cord-324054-d71rj29o 32 8 of of IN cord-324054-d71rj29o 32 9 the the DT cord-324054-d71rj29o 32 10 genes gene NNS cord-324054-d71rj29o 32 11 coding code VBG cord-324054-d71rj29o 32 12 for for IN cord-324054-d71rj29o 32 13 the the DT cord-324054-d71rj29o 32 14 structural structural JJ cord-324054-d71rj29o 32 15 proteins protein NNS cord-324054-d71rj29o 32 16 probably probably RB cord-324054-d71rj29o 32 17 is be VBZ cord-324054-d71rj29o 32 18 5'-HE 5'-he CD cord-324054-d71rj29o 32 19 - - HYPH cord-324054-d71rj29o 32 20 S s NN cord-324054-d71rj29o 32 21 - - HYPH cord-324054-d71rj29o 32 22 M M NNP cord-324054-d71rj29o 32 23 - - HYPH cord-324054-d71rj29o 32 24 N-3 N-3 NNP cord-324054-d71rj29o 32 25 ' ' '' cord-324054-d71rj29o 32 26 . . . cord-324054-d71rj29o 33 1 Recently recently RB cord-324054-d71rj29o 33 2 , , , cord-324054-d71rj29o 33 3 the the DT cord-324054-d71rj29o 33 4 N n CD cord-324054-d71rj29o 33 5 gene gene NN cord-324054-d71rj29o 33 6 of of IN cord-324054-d71rj29o 33 7 HCV HCV NNP cord-324054-d71rj29o 33 8 - - HYPH cord-324054-d71rj29o 33 9 OC43 OC43 NNP cord-324054-d71rj29o 33 10 was be VBD cord-324054-d71rj29o 33 11 sequenced sequence VBN cord-324054-d71rj29o 33 12 , , , cord-324054-d71rj29o 33 13 and and CC cord-324054-d71rj29o 33 14 it -PRON- PRP cord-324054-d71rj29o 33 15 was be VBD cord-324054-d71rj29o 33 16 found find VBN cord-324054-d71rj29o 33 17 to to TO cord-324054-d71rj29o 33 18 be be VB cord-324054-d71rj29o 33 19 similar similar JJ cord-324054-d71rj29o 33 20 to to IN cord-324054-d71rj29o 33 21 BCV BCV NNP cord-324054-d71rj29o 33 22 N N NNP cord-324054-d71rj29o 33 23 gene gene NN cord-324054-d71rj29o 33 24 ( ( -LRB- cord-324054-d71rj29o 33 25 97.59 97.59 CD cord-324054-d71rj29o 33 26 / / SYM cord-324054-d71rj29o 33 27 o o NN cord-324054-d71rj29o 33 28 amino amino NN cord-324054-d71rj29o 33 29 acid acid NN cord-324054-d71rj29o 33 30 sequence sequence NN cord-324054-d71rj29o 33 31 homology homology NN cord-324054-d71rj29o 33 32 ) ) -RRB- cord-324054-d71rj29o 33 33 ( ( -LRB- cord-324054-d71rj29o 33 34 26 26 CD cord-324054-d71rj29o 33 35 ) ) -RRB- cord-324054-d71rj29o 33 36 . . . cord-324054-d71rj29o 34 1 The the DT cord-324054-d71rj29o 34 2 origin origin NN cord-324054-d71rj29o 34 3 and and CC cord-324054-d71rj29o 34 4 evolutionary evolutionary JJ cord-324054-d71rj29o 34 5 relationships relationship NNS cord-324054-d71rj29o 34 6 among among IN cord-324054-d71rj29o 34 7 the the DT cord-324054-d71rj29o 34 8 HE HE NNP cord-324054-d71rj29o 34 9 genes gene NNS cord-324054-d71rj29o 34 10 of of IN cord-324054-d71rj29o 34 11 hemagglutinating hemagglutinate VBG cord-324054-d71rj29o 34 12 coronaviruses coronaviruse NNS cord-324054-d71rj29o 34 13 isolated isolate VBN cord-324054-d71rj29o 34 14 from from IN cord-324054-d71rj29o 34 15 different different JJ cord-324054-d71rj29o 34 16 species specie NNS cord-324054-d71rj29o 34 17 are be VBP cord-324054-d71rj29o 34 18 poorly poorly RB cord-324054-d71rj29o 34 19 understood understand VBN cord-324054-d71rj29o 34 20 . . . cord-324054-d71rj29o 35 1 To to TO cord-324054-d71rj29o 35 2 elucidate elucidate VB cord-324054-d71rj29o 35 3 the the DT cord-324054-d71rj29o 35 4 molecular molecular JJ cord-324054-d71rj29o 35 5 evolution evolution NN cord-324054-d71rj29o 35 6 of of IN cord-324054-d71rj29o 35 7 the the DT cord-324054-d71rj29o 35 8 coronavirus coronavirus NN cord-324054-d71rj29o 35 9 HE HE NNP cord-324054-d71rj29o 35 10 genes gene NNS cord-324054-d71rj29o 35 11 , , , cord-324054-d71rj29o 35 12 we -PRON- PRP cord-324054-d71rj29o 35 13 sequenced sequence VBD cord-324054-d71rj29o 35 14 the the DT cord-324054-d71rj29o 35 15 HE HE NNP cord-324054-d71rj29o 35 16 genes gene NNS cord-324054-d71rj29o 35 17 of of IN cord-324054-d71rj29o 35 18 HCV HCV NNP cord-324054-d71rj29o 35 19 - - HYPH cord-324054-d71rj29o 35 20 OC43 OC43 NNP cord-324054-d71rj29o 35 21 , , , cord-324054-d71rj29o 35 22 a a DT cord-324054-d71rj29o 35 23 bovine bovine JJ cord-324054-d71rj29o 35 24 respiratory respiratory JJ cord-324054-d71rj29o 35 25 coronavirus coronavirus NN cord-324054-d71rj29o 35 26 ( ( -LRB- cord-324054-d71rj29o 35 27 BRCV BRCV NNP cord-324054-d71rj29o 35 28 ) ) -RRB- cord-324054-d71rj29o 35 29 , , , cord-324054-d71rj29o 35 30 a a DT cord-324054-d71rj29o 35 31 virulent virulent JJ cord-324054-d71rj29o 35 32 , , , cord-324054-d71rj29o 35 33 and and CC cord-324054-d71rj29o 35 34 an an DT cord-324054-d71rj29o 35 35 avirulent avirulent NN cord-324054-d71rj29o 35 36 BCV BCV NNP cord-324054-d71rj29o 35 37 strains strain NNS cord-324054-d71rj29o 35 38 . . . cord-324054-d71rj29o 36 1 We -PRON- PRP cord-324054-d71rj29o 36 2 report report VBP cord-324054-d71rj29o 36 3 here here RB cord-324054-d71rj29o 36 4 the the DT cord-324054-d71rj29o 36 5 complete complete JJ cord-324054-d71rj29o 36 6 nucleotide nucleotide JJ cord-324054-d71rj29o 36 7 sequence sequence NN cord-324054-d71rj29o 36 8 of of IN cord-324054-d71rj29o 36 9 the the DT cord-324054-d71rj29o 36 10 HE HE NNP cord-324054-d71rj29o 36 11 genes gene NNS cord-324054-d71rj29o 36 12 of of IN cord-324054-d71rj29o 36 13 HCV HCV NNP cord-324054-d71rj29o 36 14 - - HYPH cord-324054-d71rj29o 36 15 OC43 OC43 NNP cord-324054-d71rj29o 36 16 and and CC cord-324054-d71rj29o 36 17 BRCV BRCV NNP cord-324054-d71rj29o 36 18 - - HYPH cord-324054-d71rj29o 36 19 G95 G95 NNP cord-324054-d71rj29o 36 20 , , , cord-324054-d71rj29o 36 21 and and CC cord-324054-d71rj29o 36 22 their -PRON- PRP$ cord-324054-d71rj29o 36 23 phylogenetic phylogenetic JJ cord-324054-d71rj29o 36 24 relatedness relatedness NN cord-324054-d71rj29o 36 25 to to IN cord-324054-d71rj29o 36 26 BCVs bcv NNS cord-324054-d71rj29o 36 27 , , , cord-324054-d71rj29o 36 28 MHV MHV NNP cord-324054-d71rj29o 36 29 , , , cord-324054-d71rj29o 36 30 and and CC cord-324054-d71rj29o 36 31 ICV ICV NNP cord-324054-d71rj29o 36 32 . . . cord-324054-d71rj29o 37 1 HCV HCV NNP cord-324054-d71rj29o 37 2 - - HYPH cord-324054-d71rj29o 37 3 OC43 OC43 NNP cord-324054-d71rj29o 37 4 was be VBD cord-324054-d71rj29o 37 5 obtained obtain VBN cord-324054-d71rj29o 37 6 from from IN cord-324054-d71rj29o 37 7 the the DT cord-324054-d71rj29o 37 8 American American NNP cord-324054-d71rj29o 37 9 Type Type NNP cord-324054-d71rj29o 37 10 Culture Culture NNP cord-324054-d71rj29o 37 11 Collection Collection NNP cord-324054-d71rj29o 37 12 ( ( -LRB- cord-324054-d71rj29o 37 13 ATCC ATCC NNP cord-324054-d71rj29o 37 14 , , , cord-324054-d71rj29o 37 15 759-VR 759-vr CD cord-324054-d71rj29o 37 16 ) ) -RRB- cord-324054-d71rj29o 37 17 and and CC cord-324054-d71rj29o 37 18 propagated propagate VBD cord-324054-d71rj29o 37 19 in in IN cord-324054-d71rj29o 37 20 human human JJ cord-324054-d71rj29o 37 21 rectal rectal JJ cord-324054-d71rj29o 37 22 tumor tumor NN cord-324054-d71rj29o 37 23 ( ( -LRB- cord-324054-d71rj29o 37 24 HRT-18 HRT-18 NNP cord-324054-d71rj29o 37 25 ) ) -RRB- cord-324054-d71rj29o 37 26 cells cell NNS cord-324054-d71rj29o 37 27 as as IN cord-324054-d71rj29o 37 28 described describe VBN cord-324054-d71rj29o 37 29 previ previ NNP cord-324054-d71rj29o 37 30 - - HYPH cord-324054-d71rj29o 37 31 ously ously NNP cord-324054-d71rj29o 37 32 ( ( -LRB- cord-324054-d71rj29o 37 33 27 27 CD cord-324054-d71rj29o 37 34 ) ) -RRB- cord-324054-d71rj29o 37 35 . . . cord-324054-d71rj29o 38 1 A a DT cord-324054-d71rj29o 38 2 bovine bovine JJ cord-324054-d71rj29o 38 3 respiratory respiratory JJ cord-324054-d71rj29o 38 4 coronavirus coronavirus NN cord-324054-d71rj29o 38 5 strain strain VB cord-324054-d71rj29o 38 6 Giessen Giessen NNP cord-324054-d71rj29o 38 7 89 89 CD cord-324054-d71rj29o 38 8 - - HYPH cord-324054-d71rj29o 38 9 4595 4595 CD cord-324054-d71rj29o 39 1 ( ( -LRB- cord-324054-d71rj29o 39 2 G95 G95 NNP cord-324054-d71rj29o 39 3 ) ) -RRB- cord-324054-d71rj29o 39 4 was be VBD cord-324054-d71rj29o 39 5 kindly kindly RB cord-324054-d71rj29o 39 6 provided provide VBN cord-324054-d71rj29o 39 7 by by IN cord-324054-d71rj29o 39 8 Dr. Dr. NNP cord-324054-d71rj29o 39 9 W. W. NNP cord-324054-d71rj29o 39 10 Herbst Herbst NNP cord-324054-d71rj29o 39 11 , , , cord-324054-d71rj29o 39 12 Institute Institute NNP cord-324054-d71rj29o 39 13 of of IN cord-324054-d71rj29o 39 14 Hygiene Hygiene NNP cord-324054-d71rj29o 39 15 and and CC cord-324054-d71rj29o 39 16 Infectious infectious JJ cord-324054-d71rj29o 39 17 Diseases Diseases NNPS cord-324054-d71rj29o 39 18 of of IN cord-324054-d71rj29o 39 19 Animals Animals NNPS cord-324054-d71rj29o 39 20 , , , cord-324054-d71rj29o 39 21 Justus Justus NNP cord-324054-d71rj29o 39 22 Liebig Liebig NNP cord-324054-d71rj29o 39 23 University University NNP cord-324054-d71rj29o 39 24 Giessen Giessen NNP cord-324054-d71rj29o 39 25 , , , cord-324054-d71rj29o 39 26 Germany Germany NNP cord-324054-d71rj29o 39 27 . . . cord-324054-d71rj29o 40 1 This this DT cord-324054-d71rj29o 40 2 virus virus NN cord-324054-d71rj29o 40 3 was be VBD cord-324054-d71rj29o 40 4 originally originally RB cord-324054-d71rj29o 40 5 isolated isolate VBN cord-324054-d71rj29o 40 6 from from IN cord-324054-d71rj29o 40 7 nasal nasal NN cord-324054-d71rj29o 40 8 swabs swab NNS cord-324054-d71rj29o 40 9 of of IN cord-324054-d71rj29o 40 10 a a DT cord-324054-d71rj29o 40 11 calf calf NN cord-324054-d71rj29o 40 12 suffering suffer VBG cord-324054-d71rj29o 40 13 from from IN cord-324054-d71rj29o 40 14 respiratory respiratory JJ cord-324054-d71rj29o 40 15 disorder disorder NN cord-324054-d71rj29o 40 16 , , , cord-324054-d71rj29o 40 17 and and CC cord-324054-d71rj29o 40 18 propagated propagate VBD cord-324054-d71rj29o 40 19 in in IN cord-324054-d71rj29o 40 20 HRT-18 HRT-18 NNP cord-324054-d71rj29o 40 21 cells cell NNS cord-324054-d71rj29o 40 22 . . . cord-324054-d71rj29o 41 1 Isolation isolation NN cord-324054-d71rj29o 41 2 and and CC cord-324054-d71rj29o 41 3 purification purification NN cord-324054-d71rj29o 41 4 of of IN cord-324054-d71rj29o 41 5 viral viral JJ cord-324054-d71rj29o 41 6 RNA RNA NNP cord-324054-d71rj29o 41 7 , , , cord-324054-d71rj29o 41 8 cDNA cdna NN cord-324054-d71rj29o 41 9 synthesis synthesis NN cord-324054-d71rj29o 41 10 , , , cord-324054-d71rj29o 41 11 double double RB cord-324054-d71rj29o 41 12 - - HYPH cord-324054-d71rj29o 41 13 stranded stranded JJ cord-324054-d71rj29o 41 14 ( ( -LRB- cord-324054-d71rj29o 41 15 ds ds NNP cord-324054-d71rj29o 41 16 ) ) -RRB- cord-324054-d71rj29o 41 17 cDNA cdna NN cord-324054-d71rj29o 41 18 amplification amplification NN cord-324054-d71rj29o 41 19 and and CC cord-324054-d71rj29o 41 20 single single RB cord-324054-d71rj29o 41 21 - - HYPH cord-324054-d71rj29o 41 22 stranded stranded JJ cord-324054-d71rj29o 41 23 ( ( -LRB- cord-324054-d71rj29o 41 24 ss ss NNP cord-324054-d71rj29o 41 25 ) ) -RRB- cord-324054-d71rj29o 41 26 cDNA cdna NN cord-324054-d71rj29o 41 27 production production NN cord-324054-d71rj29o 41 28 by by IN cord-324054-d71rj29o 41 29 polymerase polymerase NN cord-324054-d71rj29o 41 30 chain chain NN cord-324054-d71rj29o 41 31 reaction reaction NN cord-324054-d71rj29o 41 32 ( ( -LRB- cord-324054-d71rj29o 41 33 PCR PCR NNP cord-324054-d71rj29o 41 34 ) ) -RRB- cord-324054-d71rj29o 41 35 , , , cord-324054-d71rj29o 41 36 as as RB cord-324054-d71rj29o 41 37 well well RB cord-324054-d71rj29o 41 38 as as IN cord-324054-d71rj29o 41 39 DNA dna NN cord-324054-d71rj29o 41 40 sequencing sequencing NN cord-324054-d71rj29o 41 41 were be VBD cord-324054-d71rj29o 41 42 performed perform VBN cord-324054-d71rj29o 41 43 as as IN cord-324054-d71rj29o 41 44 described describe VBN cord-324054-d71rj29o 41 45 previously previously RB cord-324054-d71rj29o 41 46 ( ( -LRB- cord-324054-d71rj29o 41 47 28 28 CD cord-324054-d71rj29o 41 48 , , , cord-324054-d71rj29o 41 49 44 44 CD cord-324054-d71rj29o 41 50 ) ) -RRB- cord-324054-d71rj29o 41 51 . . . cord-324054-d71rj29o 42 1 Primers primer NNS cord-324054-d71rj29o 42 2 were be VBD cord-324054-d71rj29o 42 3 designed design VBN cord-324054-d71rj29o 42 4 to to TO cord-324054-d71rj29o 42 5 generate generate VB cord-324054-d71rj29o 42 6 cDNA cdna NN cord-324054-d71rj29o 42 7 fragments fragment NNS cord-324054-d71rj29o 42 8 from from IN cord-324054-d71rj29o 42 9 virus virus NN cord-324054-d71rj29o 42 10 - - HYPH cord-324054-d71rj29o 42 11 specific specific JJ cord-324054-d71rj29o 42 12 mRNAs mRNAs NNPS cord-324054-d71rj29o 42 13 by by IN cord-324054-d71rj29o 42 14 reverse reverse JJ cord-324054-d71rj29o 42 15 transcription transcription NN cord-324054-d71rj29o 42 16 and and CC cord-324054-d71rj29o 42 17 PCR PCR NNP cord-324054-d71rj29o 42 18 amplification amplification NN cord-324054-d71rj29o 42 19 , , , cord-324054-d71rj29o 42 20 based base VBN cord-324054-d71rj29o 42 21 on on IN cord-324054-d71rj29o 42 22 the the DT cord-324054-d71rj29o 42 23 high high JJ cord-324054-d71rj29o 42 24 degree degree NN cord-324054-d71rj29o 42 25 of of IN cord-324054-d71rj29o 42 26 genomic genomic JJ cord-324054-d71rj29o 42 27 similarity similarity NN cord-324054-d71rj29o 42 28 between between IN cord-324054-d71rj29o 42 29 HCV HCV NNP cord-324054-d71rj29o 42 30 - - HYPH cord-324054-d71rj29o 42 31 OC43 OC43 NNP cord-324054-d71rj29o 42 32 and and CC cord-324054-d71rj29o 42 33 BCVs BCVs NNP cord-324054-d71rj29o 42 34 ( ( -LRB- cord-324054-d71rj29o 42 35 25 25 CD cord-324054-d71rj29o 42 36 , , , cord-324054-d71rj29o 42 37 26 26 CD cord-324054-d71rj29o 42 38 ) ) -RRB- cord-324054-d71rj29o 42 39 . . . cord-324054-d71rj29o 43 1 These these DT cord-324054-d71rj29o 43 2 primers primer NNS cord-324054-d71rj29o 43 3 were be VBD cord-324054-d71rj29o 43 4 previously previously RB cord-324054-d71rj29o 43 5 used use VBN cord-324054-d71rj29o 43 6 for for IN cord-324054-d71rj29o 43 7 amplification amplification NN cord-324054-d71rj29o 43 8 and and CC cord-324054-d71rj29o 43 9 sequencing sequencing NN cord-324054-d71rj29o 43 10 of of IN cord-324054-d71rj29o 43 11 BCV BCV NNP cord-324054-d71rj29o 43 12 S S NNP cord-324054-d71rj29o 43 13 and and CC cord-324054-d71rj29o 43 14 HE HE NNP cord-324054-d71rj29o 43 15 genes gene VBZ cord-324054-d71rj29o 43 16 ( ( -LRB- cord-324054-d71rj29o 43 17 28,44 28,44 CD cord-324054-d71rj29o 43 18 ) ) -RRB- cord-324054-d71rj29o 43 19 . . . cord-324054-d71rj29o 44 1 PCRgenerated pcrgenerate VBN cord-324054-d71rj29o 44 2 cDNA cdna NN cord-324054-d71rj29o 44 3 fragments fragment NNS cord-324054-d71rj29o 44 4 were be VBD cord-324054-d71rj29o 44 5 directly directly RB cord-324054-d71rj29o 44 6 sequenced sequence VBN cord-324054-d71rj29o 44 7 in in IN cord-324054-d71rj29o 44 8 both both DT cord-324054-d71rj29o 44 9 directions direction NNS cord-324054-d71rj29o 44 10 . . . cord-324054-d71rj29o 45 1 Analysis analysis NN cord-324054-d71rj29o 45 2 of of IN cord-324054-d71rj29o 45 3 the the DT cord-324054-d71rj29o 45 4 sequences sequence NNS cord-324054-d71rj29o 45 5 revealed reveal VBD cord-324054-d71rj29o 45 6 that that IN cord-324054-d71rj29o 45 7 a a DT cord-324054-d71rj29o 45 8 large large JJ cord-324054-d71rj29o 45 9 ORF orf NN cord-324054-d71rj29o 45 10 of of IN cord-324054-d71rj29o 45 11 1272 1272 CD cord-324054-d71rj29o 45 12 nucleotides nucleotide NNS cord-324054-d71rj29o 45 13 was be VBD cord-324054-d71rj29o 45 14 identical identical JJ cord-324054-d71rj29o 45 15 in in IN cord-324054-d71rj29o 45 16 size size NN cord-324054-d71rj29o 45 17 to to IN cord-324054-d71rj29o 45 18 the the DT cord-324054-d71rj29o 45 19 HE HE NNP cord-324054-d71rj29o 45 20 genes gene NNS cord-324054-d71rj29o 45 21 of of IN cord-324054-d71rj29o 45 22 BCVs bcv NNS cord-324054-d71rj29o 45 23 ( ( -LRB- cord-324054-d71rj29o 45 24 29 29 CD cord-324054-d71rj29o 45 25 , , , cord-324054-d71rj29o 45 26 30 30 CD cord-324054-d71rj29o 45 27 , , , cord-324054-d71rj29o 45 28 44 44 CD cord-324054-d71rj29o 45 29 ) ) -RRB- cord-324054-d71rj29o 45 30 . . . cord-324054-d71rj29o 46 1 This this DT cord-324054-d71rj29o 46 2 ORF ORF NNP cord-324054-d71rj29o 46 3 terminated terminate VBD cord-324054-d71rj29o 46 4 14 14 CD cord-324054-d71rj29o 46 5 nucleotides nucleotide NNS cord-324054-d71rj29o 46 6 upstream upstream RB cord-324054-d71rj29o 46 7 from from IN cord-324054-d71rj29o 46 8 the the DT cord-324054-d71rj29o 46 9 S S NNP cord-324054-d71rj29o 46 10 gene gene NN cord-324054-d71rj29o 46 11 ( ( -LRB- cord-324054-d71rj29o 46 12 Zhang Zhang NNP cord-324054-d71rj29o 46 13 eta/. eta/. CD cord-324054-d71rj29o 46 14 , , , cord-324054-d71rj29o 46 15 unpublished unpublished JJ cord-324054-d71rj29o 46 16 data datum NNS cord-324054-d71rj29o 46 17 ) ) -RRB- cord-324054-d71rj29o 46 18 , , , cord-324054-d71rj29o 46 19 and and CC cord-324054-d71rj29o 46 20 encoded encode VBD cord-324054-d71rj29o 46 21 a a DT cord-324054-d71rj29o 46 22 protein protein NN cord-324054-d71rj29o 46 23 of of IN cord-324054-d71rj29o 46 24 424 424 CD cord-324054-d71rj29o 46 25 amino amino NN cord-324054-d71rj29o 46 26 acid acid NN cord-324054-d71rj29o 46 27 residues residue NNS cord-324054-d71rj29o 46 28 with with IN cord-324054-d71rj29o 46 29 an an DT cord-324054-d71rj29o 46 30 estimated estimate VBN cord-324054-d71rj29o 46 31 molecular molecular JJ cord-324054-d71rj29o 46 32 weight weight NN cord-324054-d71rj29o 46 33 of of IN cord-324054-d71rj29o 46 34 47.7 47.7 CD cord-324054-d71rj29o 46 35 kDa kDa NNS cord-324054-d71rj29o 46 36 ( ( -LRB- cord-324054-d71rj29o 46 37 Figs Figs NNP cord-324054-d71rj29o 46 38 . . . cord-324054-d71rj29o 47 1 1 1 CD cord-324054-d71rj29o 47 2 and and CC cord-324054-d71rj29o 47 3 2 2 CD cord-324054-d71rj29o 47 4 ) ) -RRB- cord-324054-d71rj29o 47 5 . . . cord-324054-d71rj29o 48 1 Two two CD cord-324054-d71rj29o 48 2 identical identical JJ cord-324054-d71rj29o 48 3 sequences sequence NNS cord-324054-d71rj29o 48 4 ( ( -LRB- cord-324054-d71rj29o 48 5 CTAAAC CTAAAC NNP cord-324054-d71rj29o 48 6 ) ) -RRB- cord-324054-d71rj29o 48 7 , , , cord-324054-d71rj29o 48 8 similar similar JJ cord-324054-d71rj29o 48 9 to to IN cord-324054-d71rj29o 48 10 the the DT cord-324054-d71rj29o 48 11 consensus consensus NN cord-324054-d71rj29o 48 12 intergenie intergenie NN cord-324054-d71rj29o 48 13 sequence sequence NN cord-324054-d71rj29o 48 14 upstream upstream RB cord-324054-d71rj29o 48 15 of of IN cord-324054-d71rj29o 48 16 the the DT cord-324054-d71rj29o 48 17 HCV HCV NNP cord-324054-d71rj29o 48 18 - - HYPH cord-324054-d71rj29o 48 19 OC43 OC43 NNP cord-324054-d71rj29o 48 20 N n CD cord-324054-d71rj29o 48 21 gene gene NN cord-324054-d71rj29o 48 22 ( ( -LRB- cord-324054-d71rj29o 48 23 CTAAAT CTAAAT NNP cord-324054-d71rj29o 48 24 ) ) -RRB- cord-324054-d71rj29o 48 25 ( ( -LRB- cord-324054-d71rj29o 48 26 26 26 CD cord-324054-d71rj29o 48 27 ) ) -RRB- cord-324054-d71rj29o 48 28 and and CC cord-324054-d71rj29o 48 29 identical identical JJ cord-324054-d71rj29o 48 30 to to IN cord-324054-d71rj29o 48 31 the the DT cord-324054-d71rj29o 48 32 consensus consensus NN cord-324054-d71rj29o 48 33 sequence sequence NN cord-324054-d71rj29o 48 34 upstream upstream RB cord-324054-d71rj29o 48 35 of of IN cord-324054-d71rj29o 48 36 BCV BCV NNP cord-324054-d71rj29o 48 37 HE HE NNP cord-324054-d71rj29o 48 38 and and CC cord-324054-d71rj29o 48 39 S S NNP cord-324054-d71rj29o 48 40 genes gene NNS cord-324054-d71rj29o 48 41 , , , cord-324054-d71rj29o 48 42 were be VBD cord-324054-d71rj29o 48 43 found find VBN cord-324054-d71rj29o 48 44 16 16 CD cord-324054-d71rj29o 48 45 nt nt RB cord-324054-d71rj29o 48 46 upstream upstream RB cord-324054-d71rj29o 48 47 of of IN cord-324054-d71rj29o 48 48 the the DT cord-324054-d71rj29o 48 49 predicted predict VBN cord-324054-d71rj29o 48 50 initiation initiation NN cord-324054-d71rj29o 48 51 codon codon NN cord-324054-d71rj29o 48 52 ( ( -LRB- cord-324054-d71rj29o 48 53 at at IN cord-324054-d71rj29o 48 54 nucleotides nucleotide NNS cord-324054-d71rj29o 48 55 16 16 CD cord-324054-d71rj29o 48 56 to to TO cord-324054-d71rj29o 48 57 18 18 CD cord-324054-d71rj29o 48 58 ) ) -RRB- cord-324054-d71rj29o 48 59 for for IN cord-324054-d71rj29o 48 60 the the DT cord-324054-d71rj29o 48 61 HE HE NNP cord-324054-d71rj29o 48 62 protein protein NN cord-324054-d71rj29o 48 63 and and CC cord-324054-d71rj29o 48 64 8 8 CD cord-324054-d71rj29o 48 65 nt nt RB cord-324054-d71rj29o 48 66 downstream downstream RB cord-324054-d71rj29o 48 67 from from IN cord-324054-d71rj29o 48 68 the the DT cord-324054-d71rj29o 48 69 termination termination NN cord-324054-d71rj29o 48 70 codon codon NN cord-324054-d71rj29o 48 71 , , , cord-324054-d71rj29o 48 72 respectively respectively RB cord-324054-d71rj29o 48 73 . . . cord-324054-d71rj29o 49 1 Hydropathic Hydropathic NNP cord-324054-d71rj29o 49 2 analysis analysis NN cord-324054-d71rj29o 49 3 of of IN cord-324054-d71rj29o 49 4 the the DT cord-324054-d71rj29o 49 5 predicted predict VBN cord-324054-d71rj29o 49 6 amino amino NN cord-324054-d71rj29o 49 7 acid acid NN cord-324054-d71rj29o 49 8 sequence sequence NN cord-324054-d71rj29o 49 9 indicated indicate VBD cord-324054-d71rj29o 49 10 that that IN cord-324054-d71rj29o 49 11 the the DT cord-324054-d71rj29o 49 12 putative putative JJ cord-324054-d71rj29o 49 13 HE HE NNP cord-324054-d71rj29o 49 14 protein protein NN cord-324054-d71rj29o 49 15 possessed possess VBD cord-324054-d71rj29o 49 16 the the DT cord-324054-d71rj29o 49 17 characteristics characteristic NNS cord-324054-d71rj29o 49 18 of of IN cord-324054-d71rj29o 49 19 a a DT cord-324054-d71rj29o 49 20 membrane membrane NN cord-324054-d71rj29o 49 21 protein protein NN cord-324054-d71rj29o 49 22 . . . cord-324054-d71rj29o 50 1 Specifically specifically RB cord-324054-d71rj29o 50 2 , , , cord-324054-d71rj29o 50 3 a a DT cord-324054-d71rj29o 50 4 hydrophobic hydrophobic JJ cord-324054-d71rj29o 50 5 stretch stretch NN cord-324054-d71rj29o 50 6 of of IN cord-324054-d71rj29o 50 7 15 15 CD cord-324054-d71rj29o 50 8 amino amino NN cord-324054-d71rj29o 50 9 acids acid NNS cord-324054-d71rj29o 50 10 at at IN cord-324054-d71rj29o 50 11 the the DT cord-324054-d71rj29o 50 12 N n CD cord-324054-d71rj29o 50 13 - - HYPH cord-324054-d71rj29o 50 14 terminus terminus NN cord-324054-d71rj29o 50 15 may may MD cord-324054-d71rj29o 50 16 serve serve VB cord-324054-d71rj29o 50 17 as as IN cord-324054-d71rj29o 50 18 signal signal NN cord-324054-d71rj29o 50 19 peptide peptide NN cord-324054-d71rj29o 50 20 with with IN cord-324054-d71rj29o 50 21 a a DT cord-324054-d71rj29o 50 22 cleavage cleavage NN cord-324054-d71rj29o 50 23 site site NN cord-324054-d71rj29o 50 24 between between IN cord-324054-d71rj29o 50 25 amino amino JJ cord-324054-d71rj29o 50 26 acids acid NNS cord-324054-d71rj29o 50 27 15 15 CD cord-324054-d71rj29o 50 28 and and CC cord-324054-d71rj29o 50 29 16 16 CD cord-324054-d71rj29o 50 30 ( ( -LRB- cord-324054-d71rj29o 50 31 30 30 CD cord-324054-d71rj29o 50 32 , , , cord-324054-d71rj29o 50 33 31 31 CD cord-324054-d71rj29o 50 34 , , , cord-324054-d71rj29o 50 35 44 44 CD cord-324054-d71rj29o 50 36 ) ) -RRB- cord-324054-d71rj29o 50 37 . . . cord-324054-d71rj29o 51 1 Another another DT cord-324054-d71rj29o 51 2 hydrophobic hydrophobic JJ cord-324054-d71rj29o 51 3 amino amino NN cord-324054-d71rj29o 51 4 acid acid NN cord-324054-d71rj29o 51 5 sequence sequence NN cord-324054-d71rj29o 51 6 near near IN cord-324054-d71rj29o 51 7 the the DT cord-324054-d71rj29o 51 8 C C NNP cord-324054-d71rj29o 51 9 - - HYPH cord-324054-d71rj29o 51 10 terminus terminus NN cord-324054-d71rj29o 51 11 ( ( -LRB- cord-324054-d71rj29o 51 12 amino amino JJ cord-324054-d71rj29o 51 13 acids acid NNS cord-324054-d71rj29o 51 14 389 389 CD cord-324054-d71rj29o 51 15 to to TO cord-324054-d71rj29o 51 16 414 414 CD cord-324054-d71rj29o 51 17 ) ) -RRB- cord-324054-d71rj29o 51 18 may may MD cord-324054-d71rj29o 51 19 serve serve VB cord-324054-d71rj29o 51 20 as as IN cord-324054-d71rj29o 51 21 the the DT cord-324054-d71rj29o 51 22 transmembrane transmembrane NN cord-324054-d71rj29o 51 23 domain domain NN cord-324054-d71rj29o 51 24 anchoring anchor VBG cord-324054-d71rj29o 51 25 the the DT cord-324054-d71rj29o 51 26 protein protein NN cord-324054-d71rj29o 51 27 in in IN cord-324054-d71rj29o 51 28 the the DT cord-324054-d71rj29o 51 29 viral viral JJ cord-324054-d71rj29o 51 30 envelope envelope NN cord-324054-d71rj29o 51 31 . . . cord-324054-d71rj29o 52 1 A a DT cord-324054-d71rj29o 52 2 hydrophilic hydrophilic JJ cord-324054-d71rj29o 52 3 sequence sequence NN cord-324054-d71rj29o 52 4 of of IN cord-324054-d71rj29o 52 5 10 10 CD cord-324054-d71rj29o 52 6 amino amino NN cord-324054-d71rj29o 52 7 acids acid NNS cord-324054-d71rj29o 52 8 at at IN cord-324054-d71rj29o 52 9 the the DT cord-324054-d71rj29o 52 10 C C NNP cord-324054-d71rj29o 52 11 - - HYPH cord-324054-d71rj29o 52 12 terminus terminus NN cord-324054-d71rj29o 52 13 may may MD cord-324054-d71rj29o 52 14 serve serve VB cord-324054-d71rj29o 52 15 as as IN cord-324054-d71rj29o 52 16 an an DT cord-324054-d71rj29o 52 17 intravirion intravirion NN cord-324054-d71rj29o 52 18 - - HYPH cord-324054-d71rj29o 52 19 domain domain NN cord-324054-d71rj29o 52 20 . . . cord-324054-d71rj29o 53 1 Ten ten CD cord-324054-d71rj29o 53 2 potential potential JJ cord-324054-d71rj29o 53 3 A/-linked a/-linked JJ cord-324054-d71rj29o 53 4 glycosylation glycosylation NN cord-324054-d71rj29o 53 5 sites site NNS cord-324054-d71rj29o 53 6 were be VBD cord-324054-d71rj29o 53 7 predicted predict VBN cord-324054-d71rj29o 53 8 in in IN cord-324054-d71rj29o 53 9 the the DT cord-324054-d71rj29o 53 10 HE HE NNP cord-324054-d71rj29o 53 11 protein protein NN cord-324054-d71rj29o 53 12 of of IN cord-324054-d71rj29o 53 13 HCV HCV NNP cord-324054-d71rj29o 53 14 - - HYPH cord-324054-d71rj29o 53 15 OC43 OC43 NNP cord-324054-d71rj29o 53 16 while while IN cord-324054-d71rj29o 53 17 nine nine CD cord-324054-d71rj29o 53 18 of of IN cord-324054-d71rj29o 53 19 them -PRON- PRP cord-324054-d71rj29o 53 20 were be VBD cord-324054-d71rj29o 53 21 present present JJ cord-324054-d71rj29o 53 22 in in IN cord-324054-d71rj29o 53 23 that that DT cord-324054-d71rj29o 53 24 of of IN cord-324054-d71rj29o 53 25 BRCV BRCV NNP cord-324054-d71rj29o 53 26 - - HYPH cord-324054-d71rj29o 53 27 G95 G95 NNP cord-324054-d71rj29o 53 28 . . . cord-324054-d71rj29o 54 1 Two two CD cord-324054-d71rj29o 54 2 internal internal JJ cord-324054-d71rj29o 54 3 ORFs orf NNS cord-324054-d71rj29o 54 4 were be VBD cord-324054-d71rj29o 54 5 predicted predict VBN cord-324054-d71rj29o 54 6 within within IN cord-324054-d71rj29o 54 7 the the DT cord-324054-d71rj29o 54 8 large large JJ cord-324054-d71rj29o 54 9 ORF ORF NNP cord-324054-d71rj29o 54 10 extending extend VBG cord-324054-d71rj29o 54 11 from from IN cord-324054-d71rj29o 54 12 nt nt RB cord-324054-d71rj29o 54 13 107 107 CD cord-324054-d71rj29o 54 14 to to IN cord-324054-d71rj29o 54 15 517 517 CD cord-324054-d71rj29o 54 16 and and CC cord-324054-d71rj29o 54 17 from from IN cord-324054-d71rj29o 54 18 976 976 CD cord-324054-d71rj29o 54 19 to to IN cord-324054-d71rj29o 54 20 1228 1228 CD cord-324054-d71rj29o 54 21 . . . cord-324054-d71rj29o 55 1 By by IN cord-324054-d71rj29o 55 2 analogy analogy NN cord-324054-d71rj29o 55 3 to to IN cord-324054-d71rj29o 55 4 BCV BCV NNP cord-324054-d71rj29o 55 5 HE HE NNP cord-324054-d71rj29o 55 6 gene gene NN cord-324054-d71rj29o 55 7 , , , cord-324054-d71rj29o 55 8 these these DT cord-324054-d71rj29o 55 9 results result NNS cord-324054-d71rj29o 55 10 suggest suggest VBP cord-324054-d71rj29o 55 11 that that IN cord-324054-d71rj29o 55 12 the the DT cord-324054-d71rj29o 55 13 predicted predict VBN cord-324054-d71rj29o 55 14 large large JJ cord-324054-d71rj29o 55 15 ORF ORF NNP cord-324054-d71rj29o 55 16 2b 2b CD cord-324054-d71rj29o 55 17 represents represent VBZ cord-324054-d71rj29o 55 18 mRNA mRNA NNP cord-324054-d71rj29o 55 19 2-l 2-l CD cord-324054-d71rj29o 55 20 of of IN cord-324054-d71rj29o 55 21 HCV HCV NNP cord-324054-d71rj29o 55 22 - - HYPH cord-324054-d71rj29o 55 23 OC43 OC43 NNP cord-324054-d71rj29o 55 24 and and CC cord-324054-d71rj29o 55 25 BRCV BRCV NNP cord-324054-d71rj29o 55 26 - - HYPH cord-324054-d71rj29o 55 27 G95 G95 NNP cord-324054-d71rj29o 55 28 , , , cord-324054-d71rj29o 55 29 encoding encode VBG cord-324054-d71rj29o 55 30 the the DT cord-324054-d71rj29o 55 31 HE HE NNP cord-324054-d71rj29o 55 32 glycoprotein glycoprotein NN cord-324054-d71rj29o 55 33 . . . cord-324054-d71rj29o 56 1 The the DT cord-324054-d71rj29o 56 2 predicted predict VBN cord-324054-d71rj29o 56 3 amino amino NN cord-324054-d71rj29o 56 4 acid acid NN cord-324054-d71rj29o 56 5 sequences sequence NNS cord-324054-d71rj29o 56 6 of of IN cord-324054-d71rj29o 56 7 the the DT cord-324054-d71rj29o 56 8 HE HE NNP cord-324054-d71rj29o 56 9 genes gene VBZ cord-324054-d71rj29o 56 10 from from IN cord-324054-d71rj29o 56 11 HCV HCV NNP cord-324054-d71rj29o 56 12 - - HYPH cord-324054-d71rj29o 56 13 OC43 OC43 NNP cord-324054-d71rj29o 56 14 and and CC cord-324054-d71rj29o 56 15 BRCV BRCV NNP cord-324054-d71rj29o 56 16 - - HYPH cord-324054-d71rj29o 56 17 G95 G95 NNP cord-324054-d71rj29o 56 18 ( ( -LRB- cord-324054-d71rj29o 56 19 Fig Fig NNP cord-324054-d71rj29o 56 20 . . . cord-324054-d71rj29o 56 21 l l NNP cord-324054-d71rj29o 56 22 ) ) -RRB- cord-324054-d71rj29o 56 23 , , , cord-324054-d71rj29o 56 24 BCV- BCV- NNP cord-324054-d71rj29o 56 25 ( ( -LRB- cord-324054-d71rj29o 56 26 29 29 CD cord-324054-d71rj29o 56 27 ) ) -RRB- cord-324054-d71rj29o 56 28 , , , cord-324054-d71rj29o 56 29 BCV BCV NNP cord-324054-d71rj29o 56 30 - - HYPH cord-324054-d71rj29o 56 31 L9 L9 NNP cord-324054-d71rj29o 56 32 , , , cord-324054-d71rj29o 56 33 BCV BCV NNP cord-324054-d71rj29o 56 34 - - HYPH cord-324054-d71rj29o 56 35 LY138 LY138 NNP cord-324054-d71rj29o 56 36 ( ( -LRB- cord-324054-d71rj29o 56 37 44 44 CD cord-324054-d71rj29o 56 38 ) ) -RRB- cord-324054-d71rj29o 56 39 , , , cord-324054-d71rj29o 56 40 MHV MHV NNP cord-324054-d71rj29o 56 41 - - HYPH cord-324054-d71rj29o 56 42 A59 A59 NNP cord-324054-d71rj29o 56 43 ( ( -LRB- cord-324054-d71rj29o 56 44 IO IO NNP cord-324054-d71rj29o 56 45 ) ) -RRB- cord-324054-d71rj29o 56 46 , , , cord-324054-d71rj29o 56 47 MHV MHV NNP cord-324054-d71rj29o 56 48 - - HYPH cord-324054-d71rj29o 56 49 JHM JHM NNP cord-324054-d71rj29o 56 50 ( ( -LRB- cord-324054-d71rj29o 56 51 11 11 CD cord-324054-d71rj29o 56 52 ) ) -RRB- cord-324054-d71rj29o 56 53 were be VBD cord-324054-d71rj29o 56 54 aligned align VBN cord-324054-d71rj29o 56 55 using use VBG cord-324054-d71rj29o 56 56 the the DT cord-324054-d71rj29o 56 57 programs program NNS cord-324054-d71rj29o 56 58 of of IN cord-324054-d71rj29o 56 59 the the DT cord-324054-d71rj29o 56 60 University University NNP cord-324054-d71rj29o 56 61 of of IN cord-324054-d71rj29o 56 62 Wisconsin Wisconsin NNP cord-324054-d71rj29o 56 63 Genetic Genetic NNP cord-324054-d71rj29o 56 64 Computer Computer NNP cord-324054-d71rj29o 56 65 Group Group NNP cord-324054-d71rj29o 56 66 software software NN cord-324054-d71rj29o 56 67 package package NN cord-324054-d71rj29o 56 68 , , , cord-324054-d71rj29o 56 69 version version NN cord-324054-d71rj29o 56 70 6.1 6.1 CD cord-324054-d71rj29o 56 71 . . . cord-324054-d71rj29o 57 1 The the DT cord-324054-d71rj29o 57 2 alignment alignment NN cord-324054-d71rj29o 57 3 revealed reveal VBD cord-324054-d71rj29o 57 4 that that IN cord-324054-d71rj29o 57 5 the the DT cord-324054-d71rj29o 57 6 HE HE NNP cord-324054-d71rj29o 57 7 gene gene NN cord-324054-d71rj29o 57 8 of of IN cord-324054-d71rj29o 57 9 HCV HCV NNP cord-324054-d71rj29o 57 10 - - HYPH cord-324054-d71rj29o 57 11 OC43 OC43 NNP cord-324054-d71rj29o 57 12 was be VBD cord-324054-d71rj29o 57 13 more more RBR cord-324054-d71rj29o 57 14 closely closely RB cord-324054-d71rj29o 57 15 related relate VBN cord-324054-d71rj29o 57 16 to to IN cord-324054-d71rj29o 57 17 BRCV-95 BRCV-95 NNP cord-324054-d71rj29o 57 18 and and CC cord-324054-d71rj29o 57 19 BCVs bcv NNS cord-324054-d71rj29o 57 20 than than IN cord-324054-d71rj29o 57 21 to to IN cord-324054-d71rj29o 57 22 MHVs MHVs NNP cord-324054-d71rj29o 57 23 . . . cord-324054-d71rj29o 58 1 Nucleotide nucleotide JJ cord-324054-d71rj29o 58 2 and and CC cord-324054-d71rj29o 58 3 amino amino NN cord-324054-d71rj29o 58 4 acid acid NN cord-324054-d71rj29o 58 5 sequences sequence NNS cord-324054-d71rj29o 58 6 among among IN cord-324054-d71rj29o 58 7 HCV HCV NNP cord-324054-d71rj29o 58 8 - - HYPH cord-324054-d71rj29o 58 9 OC43 OC43 NNP cord-324054-d71rj29o 58 10 , , , cord-324054-d71rj29o 58 11 BRCV BRCV NNP cord-324054-d71rj29o 58 12 - - HYPH cord-324054-d71rj29o 58 13 G95 G95 NNP cord-324054-d71rj29o 58 14 , , , cord-324054-d71rj29o 58 15 and and CC cord-324054-d71rj29o 58 16 BCVs bcv NNS cord-324054-d71rj29o 58 17 were be VBD cord-324054-d71rj29o 58 18 95.8 95.8 CD cord-324054-d71rj29o 58 19 to to IN cord-324054-d71rj29o 58 20 96.3 96.3 CD cord-324054-d71rj29o 58 21 % % NN cord-324054-d71rj29o 58 22 and and CC cord-324054-d71rj29o 58 23 94.1 94.1 CD cord-324054-d71rj29o 58 24 to to IN cord-324054-d71rj29o 58 25 94.8 94.8 CD cord-324054-d71rj29o 58 26 % % NN cord-324054-d71rj29o 58 27 identical identical JJ cord-324054-d71rj29o 58 28 , , , cord-324054-d71rj29o 58 29 respectively respectively RB cord-324054-d71rj29o 58 30 , , , cord-324054-d71rj29o 58 31 while while IN cord-324054-d71rj29o 58 32 the the DT cord-324054-d71rj29o 58 33 amino amino NN cord-324054-d71rj29o 58 34 acid acid NN cord-324054-d71rj29o 58 35 sequence sequence NN cord-324054-d71rj29o 58 36 identity identity NN cord-324054-d71rj29o 58 37 between between IN cord-324054-d71rj29o 58 38 HCV HCV NNP cord-324054-d71rj29o 58 39 - - HYPH cord-324054-d71rj29o 58 40 OC43 OC43 NNP cord-324054-d71rj29o 58 41 and and CC cord-324054-d71rj29o 58 42 MHVs MHVs NNP cord-324054-d71rj29o 58 43 was be VBD cord-324054-d71rj29o 58 44 approximately approximately RB cord-324054-d71rj29o 58 45 60 60 CD cord-324054-d71rj29o 58 46 % % NN cord-324054-d71rj29o 58 47 . . . cord-324054-d71rj29o 59 1 Fourteen fourteen CD cord-324054-d71rj29o 59 2 cysteine cysteine NN cord-324054-d71rj29o 59 3 residues residue NNS cord-324054-d71rj29o 59 4 were be VBD cord-324054-d71rj29o 59 5 strictly strictly RB cord-324054-d71rj29o 59 6 conserved conserve VBN cord-324054-d71rj29o 59 7 in in IN cord-324054-d71rj29o 59 8 the the DT cord-324054-d71rj29o 59 9 HE HE NNP cord-324054-d71rj29o 59 10 proteins protein NNS cord-324054-d71rj29o 59 11 of of IN cord-324054-d71rj29o 59 12 HCV HCV NNP cord-324054-d71rj29o 59 13 - - HYPH cord-324054-d71rj29o 59 14 OC43 OC43 NNP cord-324054-d71rj29o 59 15 , , , cord-324054-d71rj29o 59 16 BRCV BRCV NNP cord-324054-d71rj29o 59 17 - - HYPH cord-324054-d71rj29o 59 18 G95 G95 NNP cord-324054-d71rj29o 59 19 , , , cord-324054-d71rj29o 59 20 BCVs bcv NNS cord-324054-d71rj29o 59 21 , , , cord-324054-d71rj29o 59 22 and and CC cord-324054-d71rj29o 59 23 MHVs MHVs NNP cord-324054-d71rj29o 59 24 . . . cord-324054-d71rj29o 60 1 The the DT cord-324054-d71rj29o 60 2 MHV MHV NNP cord-324054-d71rj29o 60 3 - - HYPH cord-324054-d71rj29o 60 4 JHM JHM NNP cord-324054-d71rj29o 60 5 had have VBD cord-324054-d71rj29o 60 6 15 15 CD cord-324054-d71rj29o 60 7 amino amino NN cord-324054-d71rj29o 60 8 acids acid NNS cord-324054-d71rj29o 60 9 and and CC cord-324054-d71rj29o 60 10 two two CD cord-324054-d71rj29o 60 11 cysteine cysteine NN cord-324054-d71rj29o 60 12 residues residue NNS cord-324054-d71rj29o 60 13 more more JJR cord-324054-d71rj29o 60 14 than than IN cord-324054-d71rj29o 60 15 HCV HCV NNP cord-324054-d71rj29o 60 16 - - HYPH cord-324054-d71rj29o 60 17 OC43 OC43 NNP cord-324054-d71rj29o 60 18 and and CC cord-324054-d71rj29o 60 19 BRCV BRCV NNP cord-324054-d71rj29o 60 20 - - HYPH cord-324054-d71rj29o 60 21 G95 G95 NNP cord-324054-d71rj29o 60 22 . . . cord-324054-d71rj29o 61 1 The the DT cord-324054-d71rj29o 61 2 alignment alignment NN cord-324054-d71rj29o 61 3 indicated indicate VBD cord-324054-d71rj29o 61 4 that that IN cord-324054-d71rj29o 61 5 the the DT cord-324054-d71rj29o 61 6 eight eight CD cord-324054-d71rj29o 61 7 HE HE NNP cord-324054-d71rj29o 61 8 genes gene VBZ cord-324054-d71rj29o 61 9 among among IN cord-324054-d71rj29o 61 10 coronaviruses coronaviruse NNS cord-324054-d71rj29o 61 11 can can MD cord-324054-d71rj29o 61 12 be be VB cord-324054-d71rj29o 61 13 divided divide VBN cord-324054-d71rj29o 61 14 into into IN cord-324054-d71rj29o 61 15 two two CD cord-324054-d71rj29o 61 16 groups group NNS cord-324054-d71rj29o 61 17 . . . cord-324054-d71rj29o 62 1 The the DT cord-324054-d71rj29o 62 2 first first JJ cord-324054-d71rj29o 62 3 group group NN cord-324054-d71rj29o 62 4 includes include VBZ cord-324054-d71rj29o 62 5 HCV HCV NNP cord-324054-d71rj29o 62 6 - - HYPH cord-324054-d71rj29o 62 7 OC43 OC43 NNP cord-324054-d71rj29o 62 8 , , , cord-324054-d71rj29o 62 9 BRCV BRCV NNP cord-324054-d71rj29o 62 10 - - HYPH cord-324054-d71rj29o 62 11 G95 G95 NNP cord-324054-d71rj29o 62 12 , , , cord-324054-d71rj29o 62 13 and and CC cord-324054-d71rj29o 62 14 all all DT cord-324054-d71rj29o 62 15 BCVs bcv NNS cord-324054-d71rj29o 62 16 , , , cord-324054-d71rj29o 62 17 and and CC cord-324054-d71rj29o 62 18 the the DT cord-324054-d71rj29o 62 19 second second JJ cord-324054-d71rj29o 62 20 group group NN cord-324054-d71rj29o 62 21 includes include VBZ cord-324054-d71rj29o 62 22 MHV MHV NNP cord-324054-d71rj29o 62 23 - - HYPH cord-324054-d71rj29o 62 24 JHM JHM NNP cord-324054-d71rj29o 62 25 and and CC cord-324054-d71rj29o 62 26 MHV MHV NNP cord-324054-d71rj29o 62 27 - - HYPH cord-324054-d71rj29o 62 28 A59 A59 NNP cord-324054-d71rj29o 62 29 . . . cord-324054-d71rj29o 63 1 To to TO cord-324054-d71rj29o 63 2 identify identify VB cord-324054-d71rj29o 63 3 a a DT cord-324054-d71rj29o 63 4 possible possible JJ cord-324054-d71rj29o 63 5 evolutionary evolutionary JJ cord-324054-d71rj29o 63 6 pathway pathway NN cord-324054-d71rj29o 63 7 for for IN cord-324054-d71rj29o 63 8 the the DT cord-324054-d71rj29o 63 9 HE HE NNP cord-324054-d71rj29o 63 10 gene gene NN cord-324054-d71rj29o 63 11 of of IN cord-324054-d71rj29o 63 12 coronaviruses coronaviruse NNS cord-324054-d71rj29o 63 13 , , , cord-324054-d71rj29o 63 14 we -PRON- PRP cord-324054-d71rj29o 63 15 compared compare VBD cord-324054-d71rj29o 63 16 the the DT cord-324054-d71rj29o 63 17 coronavirus coronavirus NN cord-324054-d71rj29o 63 18 HE he PRP cord-324054-d71rj29o 63 19 genes gene VBZ cord-324054-d71rj29o 63 20 with with IN cord-324054-d71rj29o 63 21 the the DT cord-324054-d71rj29o 63 22 ICV ICV NNP cord-324054-d71rj29o 63 23 HE HE NNP cord-324054-d71rj29o 63 24 gene gene NN cord-324054-d71rj29o 63 25 . . . cord-324054-d71rj29o 64 1 An an DT cord-324054-d71rj29o 64 2 alignment alignment NN cord-324054-d71rj29o 64 3 of of IN cord-324054-d71rj29o 64 4 the the DT cord-324054-d71rj29o 64 5 predicted predict VBN cord-324054-d71rj29o 64 6 amino amino NN cord-324054-d71rj29o 64 7 acid acid NN cord-324054-d71rj29o 64 8 sequences sequence NNS cord-324054-d71rj29o 64 9 is be VBZ cord-324054-d71rj29o 64 10 shown show VBN cord-324054-d71rj29o 64 11 in in IN cord-324054-d71rj29o 64 12 Fig Fig NNP cord-324054-d71rj29o 64 13 . . . cord-324054-d71rj29o 65 1 2 2 LS cord-324054-d71rj29o 65 2 . . . cord-324054-d71rj29o 66 1 In in IN cord-324054-d71rj29o 66 2 this this DT cord-324054-d71rj29o 66 3 alignment alignment NN cord-324054-d71rj29o 66 4 , , , cord-324054-d71rj29o 66 5 the the DT cord-324054-d71rj29o 66 6 ICV ICV NNP cord-324054-d71rj29o 66 7 HE1 HE1 NNP cord-324054-d71rj29o 66 8 subunit subunit NN cord-324054-d71rj29o 66 9 shows show VBZ cord-324054-d71rj29o 66 10 a a DT cord-324054-d71rj29o 66 11 sequence sequence NN cord-324054-d71rj29o 66 12 identity identity NN cord-324054-d71rj29o 66 13 of of IN cord-324054-d71rj29o 66 14 approximate approximate JJ cord-324054-d71rj29o 66 15 28.2 28.2 CD cord-324054-d71rj29o 66 16 % % NN cord-324054-d71rj29o 66 17 with with IN cord-324054-d71rj29o 66 18 the the DT cord-324054-d71rj29o 66 19 HE HE NNP cord-324054-d71rj29o 66 20 protein protein NN cord-324054-d71rj29o 66 21 of of IN cord-324054-d71rj29o 66 22 HCV HCV NNP cord-324054-d71rj29o 66 23 - - HYPH cord-324054-d71rj29o 66 24 OC43 OC43 NNP cord-324054-d71rj29o 66 25 , , , cord-324054-d71rj29o 66 26 BRCV BRCV NNP cord-324054-d71rj29o 66 27 - - HYPH cord-324054-d71rj29o 66 28 G95 G95 NNP cord-324054-d71rj29o 66 29 , , , cord-324054-d71rj29o 66 30 and and CC cord-324054-d71rj29o 66 31 BCVs bcv NNS cord-324054-d71rj29o 66 32 , , , cord-324054-d71rj29o 66 33 and and CC cord-324054-d71rj29o 66 34 26.3 26.3 CD cord-324054-d71rj29o 66 35 % % NN cord-324054-d71rj29o 66 36 with with IN cord-324054-d71rj29o 66 37 the the DT cord-324054-d71rj29o 66 38 HE HE NNP cord-324054-d71rj29o 66 39 protein protein NN cord-324054-d71rj29o 66 40 of of IN cord-324054-d71rj29o 66 41 MHVs MHVs NNP cord-324054-d71rj29o 66 42 . . . cord-324054-d71rj29o 67 1 The the DT cord-324054-d71rj29o 67 2 alignment alignment NN cord-324054-d71rj29o 67 3 shows show VBZ cord-324054-d71rj29o 67 4 that that IN cord-324054-d71rj29o 67 5 several several JJ cord-324054-d71rj29o 67 6 regions region NNS cord-324054-d71rj29o 67 7 are be VBP cord-324054-d71rj29o 67 8 completely completely RB cord-324054-d71rj29o 67 9 identical identical JJ cord-324054-d71rj29o 67 10 . . . cord-324054-d71rj29o 68 1 Most most RBS cord-324054-d71rj29o 68 2 importantly importantly RB cord-324054-d71rj29o 68 3 , , , cord-324054-d71rj29o 68 4 the the DT cord-324054-d71rj29o 68 5 putative putative JJ cord-324054-d71rj29o 68 6 acetylesterase acetylesterase NN cord-324054-d71rj29o 68 7 active active JJ cord-324054-d71rj29o 68 8 site site NN cord-324054-d71rj29o 68 9 ( ( -LRB- cord-324054-d71rj29o 68 10 F F NNP cord-324054-d71rj29o 68 11 - - HYPH cord-324054-d71rj29o 68 12 G G NNP cord-324054-d71rj29o 68 13 - - HYPH cord-324054-d71rj29o 68 14 D D NNP cord-324054-d71rj29o 68 15 - - HYPH cord-324054-d71rj29o 68 16 S s NN cord-324054-d71rj29o 68 17 ) ) -RRB- cord-324054-d71rj29o 68 18 ( ( -LRB- cord-324054-d71rj29o 68 19 at at IN cord-324054-d71rj29o 68 20 amino amino NN cord-324054-d71rj29o 68 21 acids acid NNS cord-324054-d71rj29o 68 22 72 72 CD cord-324054-d71rj29o 68 23 to to TO cord-324054-d71rj29o 68 24 75 75 CD cord-324054-d71rj29o 68 25 in in IN cord-324054-d71rj29o 68 26 Fig Fig NNP cord-324054-d71rj29o 68 27 . . . cord-324054-d71rj29o 69 1 2 2 LS cord-324054-d71rj29o 69 2 ) ) -RRB- cord-324054-d71rj29o 69 3 is be VBZ cord-324054-d71rj29o 69 4 conserved conserve VBN cord-324054-d71rj29o 69 5 in in IN cord-324054-d71rj29o 69 6 all all DT cord-324054-d71rj29o 69 7 HE HE NNP cord-324054-d71rj29o 69 8 proteins protein NNS cord-324054-d71rj29o 69 9 of of IN cord-324054-d71rj29o 69 10 human human JJ cord-324054-d71rj29o 69 11 , , , cord-324054-d71rj29o 69 12 bovine bovine JJ cord-324054-d71rj29o 69 13 , , , cord-324054-d71rj29o 69 14 and and CC cord-324054-d71rj29o 69 15 murine murine JJ cord-324054-d71rj29o 69 16 coronaviruses coronaviruse NNS cord-324054-d71rj29o 69 17 and and CC cord-324054-d71rj29o 69 18 ICV ICV NNP cord-324054-d71rj29o 69 19 . . . cord-324054-d71rj29o 70 1 Ten ten CD cord-324054-d71rj29o 70 2 of of IN cord-324054-d71rj29o 70 3 the the DT cord-324054-d71rj29o 70 4 14 14 CD cord-324054-d71rj29o 70 5 cysteine cysteine NN cord-324054-d71rj29o 70 6 residue residue NN cord-324054-d71rj29o 70 7 positions position NNS cord-324054-d71rj29o 70 8 of of IN cord-324054-d71rj29o 70 9 HCV HCV NNP cord-324054-d71rj29o 70 10 - - HYPH cord-324054-d71rj29o 70 11 OC43 OC43 NNP cord-324054-d71rj29o 70 12 are be VBP cord-324054-d71rj29o 70 13 conserved conserve VBN cord-324054-d71rj29o 70 14 among among IN cord-324054-d71rj29o 70 15 all all DT cord-324054-d71rj29o 70 16 HE HE NNP cord-324054-d71rj29o 70 17 proteins protein NNS cord-324054-d71rj29o 70 18 compared compare VBN cord-324054-d71rj29o 70 19 . . . cord-324054-d71rj29o 71 1 These these DT cord-324054-d71rj29o 71 2 data datum NNS cord-324054-d71rj29o 71 3 suggest suggest VBP cord-324054-d71rj29o 71 4 that that IN cord-324054-d71rj29o 71 5 these these DT cord-324054-d71rj29o 71 6 proteins protein NNS cord-324054-d71rj29o 71 7 may may MD cord-324054-d71rj29o 71 8 be be VB cord-324054-d71rj29o 71 9 evolutionarily evolutionarily RB cord-324054-d71rj29o 71 10 related related JJ cord-324054-d71rj29o 71 11 to to IN cord-324054-d71rj29o 71 12 each each DT cord-324054-d71rj29o 71 13 other other JJ cord-324054-d71rj29o 71 14 . . . cord-324054-d71rj29o 72 1 DNA dna NN cord-324054-d71rj29o 72 2 sequences sequence NNS cord-324054-d71rj29o 72 3 for for IN cord-324054-d71rj29o 72 4 each each DT cord-324054-d71rj29o 72 5 gene gene NN cord-324054-d71rj29o 72 6 were be VBD cord-324054-d71rj29o 72 7 optimally optimally RB cord-324054-d71rj29o 72 8 aligned align VBN cord-324054-d71rj29o 72 9 based base VBN cord-324054-d71rj29o 72 10 on on IN cord-324054-d71rj29o 72 11 the the DT cord-324054-d71rj29o 72 12 alignment alignment NN cord-324054-d71rj29o 72 13 of of IN cord-324054-d71rj29o 72 14 their -PRON- PRP$ cord-324054-d71rj29o 72 15 respective respective JJ cord-324054-d71rj29o 72 16 amino amino NN cord-324054-d71rj29o 72 17 acid acid NN cord-324054-d71rj29o 72 18 sequences sequence NNS cord-324054-d71rj29o 72 19 ( ( -LRB- cord-324054-d71rj29o 72 20 Fig Fig NNP cord-324054-d71rj29o 72 21 . . NNP cord-324054-d71rj29o 72 22 2 2 CD cord-324054-d71rj29o 72 23 ) ) -RRB- cord-324054-d71rj29o 72 24 . . . cord-324054-d71rj29o 73 1 A a DT cord-324054-d71rj29o 73 2 maximum maximum JJ cord-324054-d71rj29o 73 3 parsimony parsimony NN cord-324054-d71rj29o 73 4 analysis analysis NN cord-324054-d71rj29o 73 5 was be VBD cord-324054-d71rj29o 73 6 per per IN cord-324054-d71rj29o 73 7 - - HYPH cord-324054-d71rj29o 73 8 formed form VBN cord-324054-d71rj29o 73 9 on on IN cord-324054-d71rj29o 73 10 the the DT cord-324054-d71rj29o 73 11 aligned align VBN cord-324054-d71rj29o 73 12 DNA dna NN cord-324054-d71rj29o 73 13 sequences sequence NNS cord-324054-d71rj29o 73 14 to to TO cord-324054-d71rj29o 73 15 predict predict VB cord-324054-d71rj29o 73 16 possible possible JJ cord-324054-d71rj29o 73 17 phylogenetic phylogenetic JJ cord-324054-d71rj29o 73 18 relationships relationship NNS cord-324054-d71rj29o 73 19 among among IN cord-324054-d71rj29o 73 20 coronaviruses coronaviruse NNS cord-324054-d71rj29o 74 1 ( ( -LRB- cord-324054-d71rj29o 74 2 detailed detailed JJ cord-324054-d71rj29o 74 3 methodology methodology NN cord-324054-d71rj29o 74 4 for for IN cord-324054-d71rj29o 74 5 the the DT cord-324054-d71rj29o 74 6 phylogenetic phylogenetic NN cord-324054-d71rj29o 74 7 , , , cord-324054-d71rj29o 74 8 computer computer NN cord-324054-d71rj29o 74 9 - - HYPH cord-324054-d71rj29o 74 10 assisted assist VBN cord-324054-d71rj29o 74 11 analysis analysis NN cord-324054-d71rj29o 74 12 is be VBZ cord-324054-d71rj29o 74 13 described describe VBN cord-324054-d71rj29o 74 14 in in IN cord-324054-d71rj29o 74 15 the the DT cord-324054-d71rj29o 74 16 legend legend NN cord-324054-d71rj29o 74 17 of of IN cord-324054-d71rj29o 74 18 Fig Fig NNP cord-324054-d71rj29o 74 19 . . . cord-324054-d71rj29o 74 20 3 3 CD cord-324054-d71rj29o 74 21 ) ) -RRB- cord-324054-d71rj29o 74 22 . . . cord-324054-d71rj29o 75 1 Cladistic cladistic JJ cord-324054-d71rj29o 75 2 analysis analysis NN cord-324054-d71rj29o 75 3 of of IN cord-324054-d71rj29o 75 4 the the DT cord-324054-d71rj29o 75 5 DNA dna NN cord-324054-d71rj29o 75 6 sequence sequence NN cord-324054-d71rj29o 75 7 data datum NNS cord-324054-d71rj29o 75 8 resulted result VBD cord-324054-d71rj29o 75 9 in in IN cord-324054-d71rj29o 75 10 a a DT cord-324054-d71rj29o 75 11 single single JJ cord-324054-d71rj29o 75 12 phylogenetic phylogenetic JJ cord-324054-d71rj29o 75 13 hypothesis hypothesis NN cord-324054-d71rj29o 75 14 ( ( -LRB- cord-324054-d71rj29o 75 15 phylogram phylogram NNP cord-324054-d71rj29o 75 16 ) ) -RRB- cord-324054-d71rj29o 75 17 with with IN cord-324054-d71rj29o 75 18 a a DT cord-324054-d71rj29o 75 19 total total JJ cord-324054-d71rj29o 75 20 length length NN cord-324054-d71rj29o 75 21 of of IN cord-324054-d71rj29o 75 22 1503 1503 CD cord-324054-d71rj29o 75 23 steps step NNS cord-324054-d71rj29o 75 24 and and CC cord-324054-d71rj29o 75 25 a a DT cord-324054-d71rj29o 75 26 resealed reseal VBN cord-324054-d71rj29o 75 27 consistency consistency NN cord-324054-d71rj29o 75 28 index index NN cord-324054-d71rj29o 75 29 of of IN cord-324054-d71rj29o 75 30 0.962 0.962 CD cord-324054-d71rj29o 75 31 . . . cord-324054-d71rj29o 76 1 This this DT cord-324054-d71rj29o 76 2 analysis analysis NN cord-324054-d71rj29o 76 3 suggested suggest VBD cord-324054-d71rj29o 76 4 that that IN cord-324054-d71rj29o 76 5 all all DT cord-324054-d71rj29o 76 6 coronaviruses coronaviruse NNS cord-324054-d71rj29o 76 7 were be VBD cord-324054-d71rj29o 76 8 divided divide VBN cord-324054-d71rj29o 76 9 in in IN cord-324054-d71rj29o 76 10 two two CD cord-324054-d71rj29o 76 11 clades clade NNS cord-324054-d71rj29o 76 12 . . . cord-324054-d71rj29o 77 1 One one CD cord-324054-d71rj29o 77 2 clade clade NN cord-324054-d71rj29o 77 3 included include VBD cord-324054-d71rj29o 77 4 HCV HCV NNP cord-324054-d71rj29o 77 5 - - HYPH cord-324054-d71rj29o 77 6 OC43 OC43 NNP cord-324054-d71rj29o 77 7 , , , cord-324054-d71rj29o 77 8 BRCV BRCV NNP cord-324054-d71rj29o 77 9 - - HYPH cord-324054-d71rj29o 77 10 G95 G95 NNP cord-324054-d71rj29o 77 11 , , , cord-324054-d71rj29o 77 12 and and CC cord-324054-d71rj29o 77 13 BCVs bcv NNS cord-324054-d71rj29o 77 14 . . . cord-324054-d71rj29o 78 1 The the DT cord-324054-d71rj29o 78 2 other other JJ cord-324054-d71rj29o 78 3 clade clade NN cord-324054-d71rj29o 78 4 consisted consist VBD cord-324054-d71rj29o 78 5 of of IN cord-324054-d71rj29o 78 6 MHV MHV NNP cord-324054-d71rj29o 78 7 - - HYPH cord-324054-d71rj29o 78 8 JHM JHM NNP cord-324054-d71rj29o 78 9 and and CC cord-324054-d71rj29o 78 10 MHV MHV NNP cord-324054-d71rj29o 78 11 - - HYPH cord-324054-d71rj29o 78 12 A59 A59 NNP cord-324054-d71rj29o 78 13 . . . cord-324054-d71rj29o 79 1 Neither neither DT cord-324054-d71rj29o 79 2 coronaviral coronaviral JJ cord-324054-d71rj29o 79 3 clade clade NN cord-324054-d71rj29o 79 4 is be VBZ cord-324054-d71rj29o 79 5 derived derive VBN cord-324054-d71rj29o 79 6 from from IN cord-324054-d71rj29o 79 7 the the DT cord-324054-d71rj29o 79 8 other other JJ cord-324054-d71rj29o 79 9 . . . cord-324054-d71rj29o 80 1 Within within IN cord-324054-d71rj29o 80 2 the the DT cord-324054-d71rj29o 80 3 clades clade NNS cord-324054-d71rj29o 80 4 , , , cord-324054-d71rj29o 80 5 all all DT cord-324054-d71rj29o 80 6 BCVs bcv NNS cord-324054-d71rj29o 80 7 were be VBD cord-324054-d71rj29o 80 8 closely closely RB cord-324054-d71rj29o 80 9 related relate VBN cord-324054-d71rj29o 80 10 taxa taxon NNS cord-324054-d71rj29o 80 11 to to IN cord-324054-d71rj29o 80 12 HCV HCV NNP cord-324054-d71rj29o 80 13 - - HYPH cord-324054-d71rj29o 80 14 OC43 OC43 NNP cord-324054-d71rj29o 80 15 , , , cord-324054-d71rj29o 80 16 and and CC cord-324054-d71rj29o 80 17 the the DT cord-324054-d71rj29o 80 18 MHV MHV NNP cord-324054-d71rj29o 80 19 - - HYPH cord-324054-d71rj29o 80 20 JHM JHM NNP cord-324054-d71rj29o 80 21 and and CC cord-324054-d71rj29o 80 22 MHV MHV NNP cord-324054-d71rj29o 80 23 - - HYPH cord-324054-d71rj29o 80 24 A59 A59 NNP cord-324054-d71rj29o 80 25 were be VBD cord-324054-d71rj29o 80 26 sister sister NN cord-324054-d71rj29o 80 27 taxa taxon NNS cord-324054-d71rj29o 80 28 . . . cord-324054-d71rj29o 81 1 The the DT cord-324054-d71rj29o 81 2 phylogram phylogram NN cord-324054-d71rj29o 81 3 sug sug NN cord-324054-d71rj29o 81 4 - - HYPH cord-324054-d71rj29o 81 5 G g NN cord-324054-d71rj29o 81 6 TC TC NNP cord-324054-d71rj29o 81 7 GA GA NNP cord-324054-d71rj29o 81 8 CTAAACTCAGTGAAAA CTAAACTCAGTGAAAA NNP cord-324054-d71rj29o 81 9 TGTTTITGCTl'CC!XGATlTATTCTAGTTAGCTGCATAATTGGTAGCITAGGTTlTTACAACCCKCTACCAATGTTG'llTCGC tgtttitgctl'cc!xgatltattctagttagctgcataattggtagcitaggttlttacaaccckctaccaatgttg'lltcgc NN cord-324054-d71rj29o 82 1 * * NFP cord-324054-d71rj29o 82 2 * * NFP cord-324054-d71rj29o 82 3 * * NFP cord-324054-d71rj29o 82 4 * * NFP cord-324054-d71rj29o 82 5 * * NFP cord-324054-d71rj29o 82 6 * * NFP cord-324054-d71rj29o 82 7 MetPheLeuLeuProArqPheIleLeuValSerCysIleIleGlySer~ MetPheLeuLeuProArqPheIleLeuValSerCysIleIleGlySer~ . cord-324054-d71rj29o 83 1 uGlyPhe uGlyPhe NNP cord-324054-d71rj29o 84 1 ~ ~ NFP cord-324054-d71rj29o 85 1 r r LS cord-324054-d71rj29o 85 2 ~ ~ NFP cord-324054-d71rj29o 85 3 nProP nprop ADD cord-324054-d71rj29o 86 1 ~o ~o NFP cord-324054-d71rj29o 86 2 ~ ~ NFP cord-324054-d71rj29o 86 3 rAsnValValserH rAsnValValserH NNP cord-324054-d71rj29o 86 4 " " '' cord-324054-d71rj29o 86 5 " " `` cord-324054-d71rj29o 86 6 " " '' cord-324054-d71rj29o 86 7 " " '' cord-324054-d71rj29o 86 8 " " '' cord-324054-d71rj29o 86 9 " " '' cord-324054-d71rj29o 86 10 " " '' cord-324054-d71rj29o 86 11 " " '' cord-324054-d71rj29o 86 12 " " '' cord-324054-d71rj29o 86 13 " " '' cord-324054-d71rj29o 86 14 " " '' cord-324054-d71rj29o 86 15 " " '' cord-324054-d71rj29o 86 16 " " '' cord-324054-d71rj29o 86 17 " " '' cord-324054-d71rj29o 86 18 " " '' cord-324054-d71rj29o 86 19 " " '' cord-324054-d71rj29o 86 20 " " '' cord-324054-d71rj29o 86 21 " " '' cord-324054-d71rj29o 86 22 " " '' cord-324054-d71rj29o 86 23 " " '' cord-324054-d71rj29o 86 24 " " '' cord-324054-d71rj29o 86 25 " " '' cord-324054-d71rj29o 86 26 " " '' cord-324054-d71rj29o 86 27 " " '' cord-324054-d71rj29o 86 28 " " '' cord-324054-d71rj29o 86 29 " " '' cord-324054-d71rj29o 86 30 " " '' cord-324054-d71rj29o 86 31 " " '' cord-324054-d71rj29o 86 32 " " '' cord-324054-d71rj29o 86 33 " " '' cord-324054-d71rj29o 86 34 " " '' cord-324054-d71rj29o 86 35 " " '' cord-324054-d71rj29o 86 36 " " '' cord-324054-d71rj29o 86 37 " " '' cord-324054-d71rj29o 86 38 " " '' cord-324054-d71rj29o 86 39 " " '' cord-324054-d71rj29o 86 40 " " '' cord-324054-d71rj29o 86 41 " " '' cord-324054-d71rj29o 86 42 " " '' cord-324054-d71rj29o 86 43 " " '' cord-324054-d71rj29o 86 44 " " '' cord-324054-d71rj29o 86 45 " " '' cord-324054-d71rj29o 86 46 " " '' cord-324054-d71rj29o 86 47 " " '' cord-324054-d71rj29o 86 48 " " '' cord-324054-d71rj29o 86 49 " " '' cord-324054-d71rj29o 86 50 " " '' cord-324054-d71rj29o 86 51 " " '' cord-324054-d71rj29o 86 52 " " '' cord-324054-d71rj29o 86 53 " " '' cord-324054-d71rj29o 86 54 " " '' cord-324054-d71rj29o 86 55 " " '' cord-324054-d71rj29o 86 56 " " '' cord-324054-d71rj29o 86 57 " " '' cord-324054-d71rj29o 86 58 -uAlaPhePheTrpAlaLeuArqLeu---__""____"_"""""""_""""""""""""""""""""""""""""""-"- -uAlaPhePheTrpAlaLeuArqLeu---__""____"_"""""""_""""""""""""""""""""""""""""""-"- : cord-324054-d71rj29o 86 59 " " '' cord-324054-d71rj29o 86 60 " " `` cord-324054-d71rj29o 86 61 " " '' cord-324054-d71rj29o 86 62 " " '' cord-324054-d71rj29o 86 63 " " '' cord-324054-d71rj29o 86 64 " " '' cord-324054-d71rj29o 86 65 " " '' cord-324054-d71rj29o 86 66 " " '' cord-324054-d71rj29o 86 67 " " `` cord-324054-d71rj29o 86 68 The the DT cord-324054-d71rj29o 86 69 sequences sequence NNS cord-324054-d71rj29o 86 70 for for IN cord-324054-d71rj29o 86 71 BCV BCV NNP cord-324054-d71rj29o 86 72 - - HYPH cord-324054-d71rj29o 86 73 L9 L9 NNP cord-324054-d71rj29o 86 74 , , , cord-324054-d71rj29o 86 75 BCVLY138 BCVLY138 NNP cord-324054-d71rj29o 86 76 were be VBD cord-324054-d71rj29o 86 77 obtained obtain VBN cord-324054-d71rj29o 86 78 from from IN cord-324054-d71rj29o 86 79 recent recent JJ cord-324054-d71rj29o 86 80 work work NN cord-324054-d71rj29o 86 81 ( ( -LRB- cord-324054-d71rj29o 86 82 44 44 CD cord-324054-d71rj29o 86 83 ) ) -RRB- cord-324054-d71rj29o 86 84 . . . cord-324054-d71rj29o 87 1 gested geste VBD cord-324054-d71rj29o 87 2 a a DT cord-324054-d71rj29o 87 3 common common JJ cord-324054-d71rj29o 87 4 ancestor ancestor NN cord-324054-d71rj29o 87 5 of of IN cord-324054-d71rj29o 87 6 this this DT cord-324054-d71rj29o 87 7 antigenic antigenic JJ cord-324054-d71rj29o 87 8 group group NN cord-324054-d71rj29o 87 9 of of IN cord-324054-d71rj29o 87 10 and and CC cord-324054-d71rj29o 87 11 assuming assume VBG cord-324054-d71rj29o 87 12 ICV ICV NNP cord-324054-d71rj29o 87 13 as as IN cord-324054-d71rj29o 87 14 outgroup outgroup NN cord-324054-d71rj29o 87 15 . . . cord-324054-d71rj29o 88 1 The the DT cord-324054-d71rj29o 88 2 highly highly RB cord-324054-d71rj29o 88 3 variable variable JJ cord-324054-d71rj29o 88 4 recoronaviruses recoronaviruse NNS cord-324054-d71rj29o 88 5 . . . cord-324054-d71rj29o 89 1 The the DT cord-324054-d71rj29o 89 2 highly highly JJ cord-324054-d71rj29o 89 3 cell cell NN cord-324054-d71rj29o 89 4 - - HYPH cord-324054-d71rj29o 89 5 adapted adapt VBN cord-324054-d71rj29o 89 6 strains strain NNS cord-324054-d71rj29o 89 7 BCV BCV NNP cord-324054-d71rj29o 89 8 - - HYPH cord-324054-d71rj29o 89 9 gions gion NNS cord-324054-d71rj29o 89 10 ( ( -LRB- cord-324054-d71rj29o 89 11 positions position NNS cord-324054-d71rj29o 89 12 19-l 19-l CD cord-324054-d71rj29o 89 13 85 85 CD cord-324054-d71rj29o 89 14 , , , cord-324054-d71rj29o 89 15 235 235 CD cord-324054-d71rj29o 89 16 - - SYM cord-324054-d71rj29o 89 17 365,451-l 365,451-l CD cord-324054-d71rj29o 89 18 046 046 CD cord-324054-d71rj29o 89 19 , , , cord-324054-d71rj29o 89 20 1255 1255 CD cord-324054-d71rj29o 89 21 -L9 -L9 : cord-324054-d71rj29o 89 22 , , , cord-324054-d71rj29o 89 23 BCV BCV NNP cord-324054-d71rj29o 89 24 - - HYPH cord-324054-d71rj29o 89 25 Quebec Quebec NNP cord-324054-d71rj29o 89 26 , , , cord-324054-d71rj29o 89 27 and and CC cord-324054-d71rj29o 89 28 BCV BCV NNP cord-324054-d71rj29o 89 29 - - HYPH cord-324054-d71rj29o 89 30 Mebus Mebus NNP cord-324054-d71rj29o 89 31 are be VBP cord-324054-d71rj29o 89 32 closely closely RB cord-324054-d71rj29o 89 33 related related JJ cord-324054-d71rj29o 89 34 1295 1295 CD cord-324054-d71rj29o 89 35 , , , cord-324054-d71rj29o 89 36 1351 1351 CD cord-324054-d71rj29o 89 37 -1430 -1430 SYM cord-324054-d71rj29o 89 38 , , , cord-324054-d71rj29o 89 39 and and CC cord-324054-d71rj29o 89 40 1459 1459 CD cord-324054-d71rj29o 89 41 -1503 -1503 , cord-324054-d71rj29o 89 42 were be VBD cord-324054-d71rj29o 89 43 excluded exclude VBN cord-324054-d71rj29o 89 44 to to IN cord-324054-d71rj29o 89 45 the the DT cord-324054-d71rj29o 89 46 wild wild JJ cord-324054-d71rj29o 89 47 - - HYPH cord-324054-d71rj29o 89 48 types type NNS cord-324054-d71rj29o 89 49 BCV BCV NNP cord-324054-d71rj29o 89 50 - - HYPH cord-324054-d71rj29o 89 51 LY138 LY138 NNP cord-324054-d71rj29o 89 52 and and CC cord-324054-d71rj29o 89 53 BRCV BRCV NNP cord-324054-d71rj29o 89 54 - - HYPH cord-324054-d71rj29o 89 55 G95 G95 NNP cord-324054-d71rj29o 89 56 . . . cord-324054-d71rj29o 90 1 We -PRON- PRP cord-324054-d71rj29o 90 2 ex ex NN cord-324054-d71rj29o 90 3 - - : cord-324054-d71rj29o 90 4 because because IN cord-324054-d71rj29o 90 5 they -PRON- PRP cord-324054-d71rj29o 90 6 were be VBD cord-324054-d71rj29o 90 7 not not RB cord-324054-d71rj29o 90 8 aligned align VBN cord-324054-d71rj29o 90 9 with with IN cord-324054-d71rj29o 90 10 confidence confidence NN cord-324054-d71rj29o 90 11 . . . cord-324054-d71rj29o 91 1 We -PRON- PRP cord-324054-d71rj29o 91 2 cluded clude VBD cord-324054-d71rj29o 91 3 these these DT cord-324054-d71rj29o 91 4 strains strain NNS cord-324054-d71rj29o 91 5 in in IN cord-324054-d71rj29o 91 6 the the DT cord-324054-d71rj29o 91 7 final final JJ cord-324054-d71rj29o 91 8 phylogenetic phylogenetic JJ cord-324054-d71rj29o 91 9 analysis analysis NN cord-324054-d71rj29o 91 10 , , , cord-324054-d71rj29o 91 11 identified identify VBD cord-324054-d71rj29o 91 12 125 125 CD cord-324054-d71rj29o 91 13 phylogenetically phylogenetically RB cord-324054-d71rj29o 91 14 informative informative JJ cord-324054-d71rj29o 91 15 sites site NNS cord-324054-d71rj29o 91 16 ( ( -LRB- cord-324054-d71rj29o 91 17 varibecause varibecause VBP cord-324054-d71rj29o 91 18 their -PRON- PRP$ cord-324054-d71rj29o 91 19 close close JJ cord-324054-d71rj29o 91 20 relationships relationship NNS cord-324054-d71rj29o 91 21 resulted result VBD cord-324054-d71rj29o 91 22 in in IN cord-324054-d71rj29o 91 23 collapsed collapse VBN cord-324054-d71rj29o 91 24 able able JJ cord-324054-d71rj29o 91 25 sites site NNS cord-324054-d71rj29o 91 26 with with IN cord-324054-d71rj29o 91 27 at at RB cord-324054-d71rj29o 91 28 least least RBS cord-324054-d71rj29o 91 29 two two CD cord-324054-d71rj29o 91 30 taxa taxon NNS cord-324054-d71rj29o 91 31 potentially potentially RB cord-324054-d71rj29o 91 32 sharing share VBG cord-324054-d71rj29o 91 33 a a DT cord-324054-d71rj29o 91 34 branches branch NNS cord-324054-d71rj29o 91 35 in in IN cord-324054-d71rj29o 91 36 the the DT cord-324054-d71rj29o 91 37 phylogenetic phylogenetic JJ cord-324054-d71rj29o 91 38 tree tree NN cord-324054-d71rj29o 91 39 . . . cord-324054-d71rj29o 92 1 We -PRON- PRP cord-324054-d71rj29o 92 2 further far RBR cord-324054-d71rj29o 92 3 at at RB cord-324054-d71rj29o 92 4 - - HYPH cord-324054-d71rj29o 92 5 derived derive VBN cord-324054-d71rj29o 92 6 base base NN cord-324054-d71rj29o 92 7 ) ) -RRB- cord-324054-d71rj29o 92 8 from from IN cord-324054-d71rj29o 92 9 439 439 CD cord-324054-d71rj29o 92 10 aligned align VBN cord-324054-d71rj29o 92 11 base base NN cord-324054-d71rj29o 92 12 positions position NNS cord-324054-d71rj29o 92 13 . . . cord-324054-d71rj29o 93 1 The the DT cord-324054-d71rj29o 93 2 tempted tempt VBN cord-324054-d71rj29o 93 3 to to TO cord-324054-d71rj29o 93 4 analyze analyze VB cord-324054-d71rj29o 93 5 the the DT cord-324054-d71rj29o 93 6 relationship relationship NN cord-324054-d71rj29o 93 7 among among IN cord-324054-d71rj29o 93 8 the the DT cord-324054-d71rj29o 93 9 HE HE NNP cord-324054-d71rj29o 93 10 phylogram phylogram NN cord-324054-d71rj29o 93 11 shows show VBZ cord-324054-d71rj29o 93 12 an an DT cord-324054-d71rj29o 93 13 almost almost RB cord-324054-d71rj29o 93 14 identical identical JJ cord-324054-d71rj29o 93 15 topology topology NN cord-324054-d71rj29o 93 16 for for IN cord-324054-d71rj29o 93 17 the the DT cord-324054-d71rj29o 93 18 genes gene NNS cord-324054-d71rj29o 93 19 of of IN cord-324054-d71rj29o 93 20 selected select VBN cord-324054-d71rj29o 93 21 coronaviruses coronaviruse NNS cord-324054-d71rj29o 93 22 and and CC cord-324054-d71rj29o 93 23 ICV ICV NNP cord-324054-d71rj29o 93 24 based base VBN cord-324054-d71rj29o 93 25 on on IN cord-324054-d71rj29o 93 26 coronaviral coronaviral NNP cord-324054-d71rj29o 93 27 ingroup ingroup NNP cord-324054-d71rj29o 93 28 obtained obtain VBN cord-324054-d71rj29o 93 29 by by IN cord-324054-d71rj29o 93 30 the the DT cord-324054-d71rj29o 93 31 previous previous JJ cord-324054-d71rj29o 93 32 analysis analysis NN cord-324054-d71rj29o 93 33 these these DT cord-324054-d71rj29o 93 34 results result NNS cord-324054-d71rj29o 93 35 using use VBG cord-324054-d71rj29o 93 36 limited limit VBN cord-324054-d71rj29o 93 37 DNA dna NN cord-324054-d71rj29o 93 38 sequence sequence NN cord-324054-d71rj29o 93 39 information information NN cord-324054-d71rj29o 93 40 , , , cord-324054-d71rj29o 93 41 ( ( -LRB- cord-324054-d71rj29o 93 42 Fig fig NN cord-324054-d71rj29o 93 43 . . . cord-324054-d71rj29o 93 44 3 3 CD cord-324054-d71rj29o 93 45 ) ) -RRB- cord-324054-d71rj29o 93 46 . . . cord-324054-d71rj29o 94 1 ( ( -LRB- cord-324054-d71rj29o 94 2 IO IO NNP cord-324054-d71rj29o 94 3 ) ) -RRB- cord-324054-d71rj29o 94 4 , , , cord-324054-d71rj29o 94 5 and and CC cord-324054-d71rj29o 94 6 BCV BCV NNP cord-324054-d71rj29o 94 7 - - HYPH cord-324054-d71rj29o 94 8 LY138 LY138 NNP cord-324054-d71rj29o 94 9 ( ( -LRB- cord-324054-d71rj29o 94 10 44 44 CD cord-324054-d71rj29o 94 11 ) ) -RRB- cord-324054-d71rj29o 94 12 and and CC cord-324054-d71rj29o 94 13 a a DT cord-324054-d71rj29o 94 14 partial partial JJ cord-324054-d71rj29o 94 15 HE HE NNP cord-324054-d71rj29o 94 16 gene gene NN cord-324054-d71rj29o 94 17 sequence sequence NN cord-324054-d71rj29o 94 18 of of IN cord-324054-d71rj29o 94 19 ICV ICV NNP cord-324054-d71rj29o 94 20 ( ( -LRB- cord-324054-d71rj29o 94 21 32 32 CD cord-324054-d71rj29o 94 22 ) ) -RRB- cord-324054-d71rj29o 94 23 were be VBD cord-324054-d71rj29o 94 24 used use VBN cord-324054-d71rj29o 94 25 for for IN cord-324054-d71rj29o 94 26 this this DT cord-324054-d71rj29o 94 27 phylogram phylogram NN cord-324054-d71rj29o 94 28 . . . cord-324054-d71rj29o 95 1 The the DT cord-324054-d71rj29o 95 2 DNA dna NN cord-324054-d71rj29o 95 3 sequences sequence NNS cord-324054-d71rj29o 95 4 were be VBD cord-324054-d71rj29o 95 5 aligned align VBN cord-324054-d71rj29o 95 6 based base VBN cord-324054-d71rj29o 95 7 on on IN cord-324054-d71rj29o 95 8 their -PRON- PRP$ cord-324054-d71rj29o 95 9 deduced deduce VBN cord-324054-d71rj29o 95 10 amino amino NN cord-324054-d71rj29o 95 11 acid acid NN cord-324054-d71rj29o 95 12 sequence sequence NN cord-324054-d71rj29o 95 13 alignment alignment NN cord-324054-d71rj29o 95 14 as as IN cord-324054-d71rj29o 95 15 shown show VBN cord-324054-d71rj29o 95 16 in in IN cord-324054-d71rj29o 95 17 Fig Fig NNP cord-324054-d71rj29o 95 18 . . . cord-324054-d71rj29o 95 19 2 2 CD cord-324054-d71rj29o 96 1 Since since IN cord-324054-d71rj29o 96 2 the the DT cord-324054-d71rj29o 96 3 HCV HCV NNP cord-324054-d71rj29o 96 4 - - HYPH cord-324054-d71rj29o 96 5 OC43 OC43 NNP cord-324054-d71rj29o 96 6 and and CC cord-324054-d71rj29o 96 7 ICV ICV NNP cord-324054-d71rj29o 96 8 infect infect VBP cord-324054-d71rj29o 96 9 similar similar JJ cord-324054-d71rj29o 96 10 tissues tissue NNS cord-324054-d71rj29o 96 11 in in IN cord-324054-d71rj29o 96 12 human human JJ cord-324054-d71rj29o 96 13 subjects subject NNS cord-324054-d71rj29o 96 14 , , , cord-324054-d71rj29o 96 15 the the DT cord-324054-d71rj29o 96 16 significant significant JJ cord-324054-d71rj29o 96 17 sequence sequence NN cord-324054-d71rj29o 96 18 homology homology NN cord-324054-d71rj29o 96 19 between between IN cord-324054-d71rj29o 96 20 the the DT cord-324054-d71rj29o 96 21 HE HE NNP cord-324054-d71rj29o 96 22 genes gene NNS cord-324054-d71rj29o 96 23 of of IN cord-324054-d71rj29o 96 24 the the DT cord-324054-d71rj29o 96 25 two two CD cord-324054-d71rj29o 96 26 viruses virus NNS cord-324054-d71rj29o 96 27 suggests suggest VBZ cord-324054-d71rj29o 96 28 that that IN cord-324054-d71rj29o 96 29 coinfection coinfection NN cord-324054-d71rj29o 96 30 of of IN cord-324054-d71rj29o 96 31 an an DT cord-324054-d71rj29o 96 32 ancestral ancestral JJ cord-324054-d71rj29o 96 33 coronavirus coronavirus NN cord-324054-d71rj29o 96 34 with with IN cord-324054-d71rj29o 96 35 ICV ICV NNP cord-324054-d71rj29o 96 36 followed follow VBN cord-324054-d71rj29o 96 37 by by IN cord-324054-d71rj29o 96 38 recombination recombination NN cord-324054-d71rj29o 96 39 may may MD cord-324054-d71rj29o 96 40 have have VB cord-324054-d71rj29o 96 41 given give VBN cord-324054-d71rj29o 96 42 rise rise NN cord-324054-d71rj29o 96 43 to to IN cord-324054-d71rj29o 96 44 HCV HCV NNP cord-324054-d71rj29o 96 45 - - HYPH cord-324054-d71rj29o 96 46 OC43 OC43 NNP cord-324054-d71rj29o 96 47 . . . cord-324054-d71rj29o 97 1 This this DT cord-324054-d71rj29o 97 2 was be VBD cord-324054-d71rj29o 97 3 also also RB cord-324054-d71rj29o 97 4 proposed propose VBN cord-324054-d71rj29o 97 5 by by IN cord-324054-d71rj29o 97 6 Luytjes Luytjes NNP cord-324054-d71rj29o 97 7 et et NNP cord-324054-d71rj29o 97 8 al al NNP cord-324054-d71rj29o 97 9 . . . cord-324054-d71rj29o 98 1 ( ( -LRB- cord-324054-d71rj29o 98 2 10 10 CD cord-324054-d71rj29o 98 3 ) ) -RRB- cord-324054-d71rj29o 98 4 . . . cord-324054-d71rj29o 99 1 Phylogenetic phylogenetic JJ cord-324054-d71rj29o 99 2 analysis analysis NN cord-324054-d71rj29o 99 3 also also RB cord-324054-d71rj29o 99 4 suggests suggest VBZ cord-324054-d71rj29o 99 5 that that IN cord-324054-d71rj29o 99 6 the the DT cord-324054-d71rj29o 99 7 HE HE NNP cord-324054-d71rj29o 99 8 genes gene NNS cord-324054-d71rj29o 99 9 of of IN cord-324054-d71rj29o 99 10 coronaviruses coronaviruse NNS cord-324054-d71rj29o 99 11 and and CC cord-324054-d71rj29o 99 12 ICV ICV NNP cord-324054-d71rj29o 99 13 may may MD cord-324054-d71rj29o 99 14 originate originate VB cord-324054-d71rj29o 99 15 from from IN cord-324054-d71rj29o 99 16 a a DT cord-324054-d71rj29o 99 17 common common JJ cord-324054-d71rj29o 99 18 ancestor ancestor NN cord-324054-d71rj29o 99 19 . . . cord-324054-d71rj29o 100 1 It -PRON- PRP cord-324054-d71rj29o 100 2 is be VBZ cord-324054-d71rj29o 100 3 worth worth JJ cord-324054-d71rj29o 100 4 noting note VBG cord-324054-d71rj29o 100 5 that that IN cord-324054-d71rj29o 100 6 the the DT cord-324054-d71rj29o 100 7 HE HE NNP cord-324054-d71rj29o 100 8 protein protein NN cord-324054-d71rj29o 100 9 of of IN cord-324054-d71rj29o 100 10 ICV ICV NNP cord-324054-d71rj29o 100 11 contains contain VBZ cord-324054-d71rj29o 100 12 receptor receptor NN cord-324054-d71rj29o 100 13 - - HYPH cord-324054-d71rj29o 100 14 binding binding NN cord-324054-d71rj29o 100 15 , , , cord-324054-d71rj29o 100 16 acetylesterase acetylesterase NN cord-324054-d71rj29o 100 17 and and CC cord-324054-d71rj29o 100 18 fusion fusion NN cord-324054-d71rj29o 100 19 activities activity NNS cord-324054-d71rj29o 100 20 while while IN cord-324054-d71rj29o 100 21 that that DT cord-324054-d71rj29o 100 22 of of IN cord-324054-d71rj29o 100 23 coronaviruses coronaviruse NNS cord-324054-d71rj29o 100 24 contains contain VBZ cord-324054-d71rj29o 100 25 only only RB cord-324054-d71rj29o 100 26 the the DT cord-324054-d71rj29o 100 27 receptor receptor NN cord-324054-d71rj29o 100 28 - - HYPH cord-324054-d71rj29o 100 29 binding bind VBG cord-324054-d71rj29o 100 30 and and CC cord-324054-d71rj29o 100 31 acetylesterase acetylesterase NN cord-324054-d71rj29o 100 32 activities activity NNS cord-324054-d71rj29o 100 33 . . . cord-324054-d71rj29o 101 1 The the DT cord-324054-d71rj29o 101 2 fusion fusion NN cord-324054-d71rj29o 101 3 function function NN cord-324054-d71rj29o 101 4 of of IN cord-324054-d71rj29o 101 5 ICV ICV NNP cord-324054-d71rj29o 101 6 is be VBZ cord-324054-d71rj29o 101 7 associated associate VBN cord-324054-d71rj29o 101 8 with with IN cord-324054-d71rj29o 101 9 the the DT cord-324054-d71rj29o 101 10 /V /v NN cord-324054-d71rj29o 101 11 - - HYPH cord-324054-d71rj29o 101 12 terminal terminal NN cord-324054-d71rj29o 101 13 hydrophobic hydrophobic JJ cord-324054-d71rj29o 101 14 region region NN cord-324054-d71rj29o 101 15 of of IN cord-324054-d71rj29o 101 16 the the DT cord-324054-d71rj29o 101 17 HE2 HE2 NNP cord-324054-d71rj29o 101 18 subunit subunit NN cord-324054-d71rj29o 101 19 of of IN cord-324054-d71rj29o 101 20 the the DT cord-324054-d71rj29o 101 21 HE HE NNP cord-324054-d71rj29o 101 22 protein protein NN cord-324054-d71rj29o 101 23 ( ( -LRB- cord-324054-d71rj29o 101 24 17 17 CD cord-324054-d71rj29o 101 25 ) ) -RRB- cord-324054-d71rj29o 101 26 ( ( -LRB- cord-324054-d71rj29o 101 27 18 18 CD cord-324054-d71rj29o 101 28 ) ) -RRB- cord-324054-d71rj29o 101 29 ( ( -LRB- cord-324054-d71rj29o 101 30 19 19 CD cord-324054-d71rj29o 101 31 ) ) -RRB- cord-324054-d71rj29o 101 32 32 32 CD cord-324054-d71rj29o 101 33 ) ) -RRB- cord-324054-d71rj29o 101 34 . . . cord-324054-d71rj29o 102 1 A a DT cord-324054-d71rj29o 102 2 similar similar JJ cord-324054-d71rj29o 102 3 hydrophobic hydrophobic JJ cord-324054-d71rj29o 102 4 domain domain NN cord-324054-d71rj29o 102 5 was be VBD cord-324054-d71rj29o 102 6 not not RB cord-324054-d71rj29o 102 7 found find VBN cord-324054-d71rj29o 102 8 in in IN cord-324054-d71rj29o 102 9 the the DT cord-324054-d71rj29o 102 10 coronavirus coronavirus NN cord-324054-d71rj29o 102 11 HE he PRP cord-324054-d71rj29o 102 12 protein protein NN cord-324054-d71rj29o 102 13 . . . cord-324054-d71rj29o 103 1 The the DT cord-324054-d71rj29o 103 2 high high JJ cord-324054-d71rj29o 103 3 similarity similarity NN cord-324054-d71rj29o 103 4 between between IN cord-324054-d71rj29o 103 5 the the DT cord-324054-d71rj29o 103 6 HE HE NNP cord-324054-d71rj29o 103 7 proteins protein NNS cord-324054-d71rj29o 103 8 of of IN cord-324054-d71rj29o 103 9 HCV HCV NNP cord-324054-d71rj29o 103 10 - - HYPH cord-324054-d71rj29o 103 11 OC43 OC43 NNP cord-324054-d71rj29o 103 12 and and CC cord-324054-d71rj29o 103 13 BCVs BCVs NNP cord-324054-d71rj29o 103 14 ( ( -LRB- cord-324054-d71rj29o 103 15 95 95 CD cord-324054-d71rj29o 103 16 % % NN cord-324054-d71rj29o 103 17 identity identity NN cord-324054-d71rj29o 103 18 on on IN cord-324054-d71rj29o 103 19 the the DT cord-324054-d71rj29o 103 20 average average NN cord-324054-d71rj29o 103 21 ) ) -RRB- cord-324054-d71rj29o 103 22 suggests suggest VBZ cord-324054-d71rj29o 103 23 that that IN cord-324054-d71rj29o 103 24 both both DT cord-324054-d71rj29o 103 25 viruses virus NNS cord-324054-d71rj29o 103 26 are be VBP cord-324054-d71rj29o 103 27 very very RB cord-324054-d71rj29o 103 28 closely closely RB cord-324054-d71rj29o 103 29 related related JJ cord-324054-d71rj29o 103 30 . . . cord-324054-d71rj29o 104 1 This this DT cord-324054-d71rj29o 104 2 hypothesis hypothesis NN cord-324054-d71rj29o 104 3 is be VBZ cord-324054-d71rj29o 104 4 also also RB cord-324054-d71rj29o 104 5 supported support VBN cord-324054-d71rj29o 104 6 by by IN cord-324054-d71rj29o 104 7 the the DT cord-324054-d71rj29o 104 8 tree tree NN cord-324054-d71rj29o 104 9 branch branch NN cord-324054-d71rj29o 104 10 distance distance NN cord-324054-d71rj29o 104 11 in in IN cord-324054-d71rj29o 104 12 the the DT cord-324054-d71rj29o 104 13 phylogenetic phylogenetic JJ cord-324054-d71rj29o 104 14 analysis analysis NN cord-324054-d71rj29o 104 15 shown show VBN cord-324054-d71rj29o 104 16 in in IN cord-324054-d71rj29o 104 17 Fig Fig NNP cord-324054-d71rj29o 104 18 . . . cord-324054-d71rj29o 105 1 3 3 LS cord-324054-d71rj29o 105 2 . . . cord-324054-d71rj29o 106 1 Interestingly interestingly RB cord-324054-d71rj29o 106 2 , , , cord-324054-d71rj29o 106 3 the the DT cord-324054-d71rj29o 106 4 HE HE NNP cord-324054-d71rj29o 106 5 of of IN cord-324054-d71rj29o 106 6 HCV HCV NNP cord-324054-d71rj29o 106 7 - - HYPH cord-324054-d71rj29o 106 8 OC43 OC43 NNP cord-324054-d71rj29o 106 9 is be VBZ cord-324054-d71rj29o 106 10 more more RBR cord-324054-d71rj29o 106 11 closely closely RB cord-324054-d71rj29o 106 12 related related JJ cord-324054-d71rj29o 106 13 to to IN cord-324054-d71rj29o 106 14 those those DT cord-324054-d71rj29o 106 15 of of IN cord-324054-d71rj29o 106 16 BRCVG95 BRCVG95 NNP cord-324054-d71rj29o 106 17 and and CC cord-324054-d71rj29o 106 18 the the DT cord-324054-d71rj29o 106 19 wild wild JJ cord-324054-d71rj29o 106 20 - - HYPH cord-324054-d71rj29o 106 21 type type NN cord-324054-d71rj29o 106 22 , , , cord-324054-d71rj29o 106 23 virulent virulent JJ cord-324054-d71rj29o 106 24 strain strain NN cord-324054-d71rj29o 106 25 BCV BCV NNP cord-324054-d71rj29o 106 26 - - HYPH cord-324054-d71rj29o 106 27 LY138 LY138 NNP cord-324054-d71rj29o 107 1 than than IN cord-324054-d71rj29o 107 2 to to IN cord-324054-d71rj29o 107 3 that that DT cord-324054-d71rj29o 107 4 of of IN cord-324054-d71rj29o 107 5 the the DT cord-324054-d71rj29o 107 6 cell cell NN cord-324054-d71rj29o 107 7 - - HYPH cord-324054-d71rj29o 107 8 culture culture NN cord-324054-d71rj29o 107 9 adapted adapt VBN cord-324054-d71rj29o 107 10 avirulent avirulent NN cord-324054-d71rj29o 107 11 strain strain NN cord-324054-d71rj29o 107 12 BCV BCV NNP cord-324054-d71rj29o 107 13 - - HYPH cord-324054-d71rj29o 107 14 L9 L9 NNP cord-324054-d71rj29o 107 15 . . . cord-324054-d71rj29o 108 1 The the DT cord-324054-d71rj29o 108 2 wild wild JJ cord-324054-d71rj29o 108 3 - - HYPH cord-324054-d71rj29o 108 4 type type NN cord-324054-d71rj29o 108 5 strain strain NN cord-324054-d71rj29o 109 1 BCV BCV NNP cord-324054-d71rj29o 109 2 - - HYPH cord-324054-d71rj29o 109 3 LY138 LY138 NNP cord-324054-d71rj29o 109 4 does do VBZ cord-324054-d71rj29o 109 5 not not RB cord-324054-d71rj29o 109 6 replicate replicate VB cord-324054-d71rj29o 109 7 in in IN cord-324054-d71rj29o 109 8 numerous numerous JJ cord-324054-d71rj29o 109 9 bovine bovine JJ cord-324054-d71rj29o 109 10 cells cell NNS cord-324054-d71rj29o 109 11 in in IN cord-324054-d71rj29o 109 12 vitro vitro FW cord-324054-d71rj29o 109 13 , , , cord-324054-d71rj29o 109 14 but but CC cord-324054-d71rj29o 109 15 it -PRON- PRP cord-324054-d71rj29o 109 16 grows grow VBZ cord-324054-d71rj29o 109 17 readily readily RB cord-324054-d71rj29o 109 18 in in IN cord-324054-d71rj29o 109 19 human human JJ cord-324054-d71rj29o 109 20 cells cell NNS cord-324054-d71rj29o 109 21 ( ( -LRB- cord-324054-d71rj29o 109 22 HRT-18 HRT-18 NNP cord-324054-d71rj29o 109 23 ) ) -RRB- cord-324054-d71rj29o 109 24 without without IN cord-324054-d71rj29o 109 25 requiring require VBG cord-324054-d71rj29o 109 26 prior prior JJ cord-324054-d71rj29o 109 27 adaptation adaptation NN cord-324054-d71rj29o 109 28 ( ( -LRB- cord-324054-d71rj29o 109 29 27 27 CD cord-324054-d71rj29o 109 30 , , , cord-324054-d71rj29o 109 31 33 33 CD cord-324054-d71rj29o 109 32 , , , cord-324054-d71rj29o 109 33 34 34 CD cord-324054-d71rj29o 109 34 ) ) -RRB- cord-324054-d71rj29o 109 35 . . . cord-324054-d71rj29o 110 1 Since since IN cord-324054-d71rj29o 110 2 these these DT cord-324054-d71rj29o 110 3 polarized polarize VBN cord-324054-d71rj29o 110 4 human human JJ cord-324054-d71rj29o 110 5 cells cell NNS cord-324054-d71rj29o 110 6 retain retain VBP cord-324054-d71rj29o 110 7 many many JJ cord-324054-d71rj29o 110 8 features feature NNS cord-324054-d71rj29o 110 9 of of IN cord-324054-d71rj29o 110 10 primary primary JJ cord-324054-d71rj29o 110 11 epithelial epithelial JJ cord-324054-d71rj29o 110 12 cells cell NNS cord-324054-d71rj29o 110 13 , , , cord-324054-d71rj29o 110 14 infection infection NN cord-324054-d71rj29o 110 15 by by IN cord-324054-d71rj29o 110 16 BCV BCV NNP cord-324054-d71rj29o 110 17 suggests suggest VBZ cord-324054-d71rj29o 110 18 that that IN cord-324054-d71rj29o 110 19 BCV BCV NNP cord-324054-d71rj29o 110 20 may may MD cord-324054-d71rj29o 110 21 also also RB cord-324054-d71rj29o 110 22 infect infect VB cord-324054-d71rj29o 110 23 humans human NNS cord-324054-d71rj29o 110 24 , , , cord-324054-d71rj29o 110 25 and and CC cord-324054-d71rj29o 110 26 therefore therefore RB cord-324054-d71rj29o 110 27 , , , cord-324054-d71rj29o 110 28 it -PRON- PRP cord-324054-d71rj29o 110 29 is be VBZ cord-324054-d71rj29o 110 30 a a DT cord-324054-d71rj29o 110 31 zoonotic zoonotic JJ cord-324054-d71rj29o 110 32 virus virus NN cord-324054-d71rj29o 110 33 ( ( -LRB- cord-324054-d71rj29o 110 34 23 23 CD cord-324054-d71rj29o 110 35 , , , cord-324054-d71rj29o 110 36 35 35 CD cord-324054-d71rj29o 110 37 ) ) -RRB- cord-324054-d71rj29o 110 38 . . . cord-324054-d71rj29o 111 1 We -PRON- PRP cord-324054-d71rj29o 111 2 previously previously RB cord-324054-d71rj29o 111 3 reported report VBD cord-324054-d71rj29o 111 4 a a DT cord-324054-d71rj29o 111 5 case case NN cord-324054-d71rj29o 111 6 of of IN cord-324054-d71rj29o 111 7 human human JJ cord-324054-d71rj29o 111 8 diarrhea diarrhea NN cord-324054-d71rj29o 111 9 caused cause VBN cord-324054-d71rj29o 111 10 by by IN cord-324054-d71rj29o 111 11 BCV BCV NNP cord-324054-d71rj29o 111 12 - - HYPH cord-324054-d71rj29o 111 13 LY LY NNP cord-324054-d71rj29o 111 14 138 138 CD cord-324054-d71rj29o 111 15 , , , cord-324054-d71rj29o 111 16 in in IN cord-324054-d71rj29o 111 17 which which WDT cord-324054-d71rj29o 111 18 the the DT cord-324054-d71rj29o 111 19 virus virus NN cord-324054-d71rj29o 111 20 was be VBD cord-324054-d71rj29o 111 21 identified identify VBN cord-324054-d71rj29o 111 22 from from IN cord-324054-d71rj29o 111 23 the the DT cord-324054-d71rj29o 111 24 infected infected JJ cord-324054-d71rj29o 111 25 patient patient NN cord-324054-d71rj29o 111 26 ( ( -LRB- cord-324054-d71rj29o 111 27 35 35 CD cord-324054-d71rj29o 111 28 ) ) -RRB- cord-324054-d71rj29o 111 29 . . . cord-324054-d71rj29o 112 1 Recently recently RB cord-324054-d71rj29o 112 2 , , , cord-324054-d71rj29o 112 3 we -PRON- PRP cord-324054-d71rj29o 112 4 found find VBD cord-324054-d71rj29o 112 5 that that IN cord-324054-d71rj29o 112 6 BRCV BRCV NNP cord-324054-d71rj29o 112 7 - - HYPH cord-324054-d71rj29o 112 8 G95 G95 NNP cord-324054-d71rj29o 112 9 exhibited exhibit VBD cord-324054-d71rj29o 112 10 almost almost RB cord-324054-d71rj29o 112 11 identical identical JJ cord-324054-d71rj29o 112 12 cytopathology cytopathology NN cord-324054-d71rj29o 112 13 in in IN cord-324054-d71rj29o 112 14 vitro vitro FW cord-324054-d71rj29o 112 15 to to IN cord-324054-d71rj29o 112 16 the the DT cord-324054-d71rj29o 112 17 wild wild JJ cord-324054-d71rj29o 112 18 - - HYPH cord-324054-d71rj29o 112 19 type type NN cord-324054-d71rj29o 112 20 virulent virulent JJ cord-324054-d71rj29o 112 21 strains strain NNS cord-324054-d71rj29o 112 22 BCV BCV NNP cord-324054-d71rj29o 112 23 - - HYPH cord-324054-d71rj29o 112 24 LY LY NNP cord-324054-d71rj29o 112 25 138 138 CD cord-324054-d71rj29o 113 1 ( ( -LRB- cord-324054-d71rj29o 113 2 data datum NNS cord-324054-d71rj29o 113 3 not not RB cord-324054-d71rj29o 113 4 shown show VBN cord-324054-d71rj29o 113 5 ) ) -RRB- cord-324054-d71rj29o 113 6 . . . cord-324054-d71rj29o 114 1 The the DT cord-324054-d71rj29o 114 2 HCV HCV NNP cord-324054-d71rj29o 114 3 - - HYPH cord-324054-d71rj29o 114 4 OC43 OC43 NNP cord-324054-d71rj29o 114 5 , , , cord-324054-d71rj29o 114 6 BCVs bcv NNS cord-324054-d71rj29o 114 7 , , , cord-324054-d71rj29o 114 8 and and CC cord-324054-d71rj29o 114 9 BRCV BRCV NNP cord-324054-d71rj29o 114 10 - - HYPH cord-324054-d71rj29o 114 11 G95 G95 NNP cord-324054-d71rj29o 114 12 differed differ VBD cord-324054-d71rj29o 114 13 only only RB cord-324054-d71rj29o 114 14 in in IN cord-324054-d71rj29o 114 15 few few JJ cord-324054-d71rj29o 114 16 amino amino NN cord-324054-d71rj29o 114 17 acids acid NNS cord-324054-d71rj29o 114 18 in in IN cord-324054-d71rj29o 114 19 the the DT cord-324054-d71rj29o 114 20 HE HE NNP cord-324054-d71rj29o 114 21 , , , cord-324054-d71rj29o 114 22 and and CC cord-324054-d71rj29o 114 23 their -PRON- PRP$ cord-324054-d71rj29o 114 24 putative putative JJ cord-324054-d71rj29o 114 25 acetylesterase acetylesterase NN cord-324054-d71rj29o 114 26 active active JJ cord-324054-d71rj29o 114 27 sites site NNS cord-324054-d71rj29o 114 28 were be VBD cord-324054-d71rj29o 114 29 conserved conserve VBN cord-324054-d71rj29o 114 30 ( ( -LRB- cord-324054-d71rj29o 114 31 see see VB cord-324054-d71rj29o 114 32 Fig Fig NNP cord-324054-d71rj29o 114 33 . . NNP cord-324054-d71rj29o 114 34 2 2 CD cord-324054-d71rj29o 114 35 ) ) -RRB- cord-324054-d71rj29o 114 36 . . . cord-324054-d71rj29o 115 1 0-acetylneuraminic 0-acetylneuraminic CD cord-324054-d71rj29o 116 1 acid acid NN cord-324054-d71rj29o 116 2 was be VBD cord-324054-d71rj29o 116 3 shown show VBN cord-324054-d71rj29o 116 4 to to TO cord-324054-d71rj29o 116 5 be be VB cord-324054-d71rj29o 116 6 the the DT cord-324054-d71rj29o 116 7 major major JJ cord-324054-d71rj29o 116 8 determinant determinant NN cord-324054-d71rj29o 116 9 for for IN cord-324054-d71rj29o 116 10 ICV ICV NNP cord-324054-d71rj29o 116 11 ( ( -LRB- cord-324054-d71rj29o 116 12 36 36 CD cord-324054-d71rj29o 116 13 - - SYM cord-324054-d71rj29o 116 14 38 38 CD cord-324054-d71rj29o 116 15 ) ) -RRB- cord-324054-d71rj29o 116 16 . . . cord-324054-d71rj29o 117 1 HCV HCV NNP cord-324054-d71rj29o 117 2 - - HYPH cord-324054-d71rj29o 117 3 OC43 OC43 NNP cord-324054-d71rj29o 117 4 , , , cord-324054-d71rj29o 117 5 BCVs bcv NNS cord-324054-d71rj29o 117 6 , , , cord-324054-d71rj29o 117 7 and and CC cord-324054-d71rj29o 117 8 BRCV BRCV NNP cord-324054-d71rj29o 117 9 - - HYPH cord-324054-d71rj29o 117 10 G95 G95 NNP cord-324054-d71rj29o 117 11 probably probably RB cord-324054-d71rj29o 117 12 recognize recognize VBP cord-324054-d71rj29o 117 13 this this DT cord-324054-d71rj29o 117 14 receptor receptor NN cord-324054-d71rj29o 117 15 on on IN cord-324054-d71rj29o 117 16 the the DT cord-324054-d71rj29o 117 17 surface surface NN cord-324054-d71rj29o 117 18 of of IN cord-324054-d71rj29o 117 19 many many JJ cord-324054-d71rj29o 117 20 different different JJ cord-324054-d71rj29o 117 21 epithelial epithelial JJ cord-324054-d71rj29o 117 22 cells cell NNS cord-324054-d71rj29o 117 23 . . . cord-324054-d71rj29o 118 1 They -PRON- PRP cord-324054-d71rj29o 118 2 may may MD cord-324054-d71rj29o 118 3 be be VB cord-324054-d71rj29o 118 4 able able JJ cord-324054-d71rj29o 118 5 to to TO cord-324054-d71rj29o 118 6 replicate replicate VB cord-324054-d71rj29o 118 7 in in IN cord-324054-d71rj29o 118 8 epithelial epithelial JJ cord-324054-d71rj29o 118 9 cells cell NNS cord-324054-d71rj29o 118 10 of of IN cord-324054-d71rj29o 118 11 both both CC cord-324054-d71rj29o 118 12 respiratory respiratory JJ cord-324054-d71rj29o 118 13 and and CC cord-324054-d71rj29o 118 14 intestinal intestinal JJ cord-324054-d71rj29o 118 15 tracts tract NNS cord-324054-d71rj29o 118 16 , , , cord-324054-d71rj29o 118 17 and and CC cord-324054-d71rj29o 118 18 to to TO cord-324054-d71rj29o 118 19 cross cross VB cord-324054-d71rj29o 118 20 species specie NNS cord-324054-d71rj29o 118 21 - - HYPH cord-324054-d71rj29o 118 22 barriers barrier NNS cord-324054-d71rj29o 118 23 causing cause VBG cord-324054-d71rj29o 118 24 diseases disease NNS cord-324054-d71rj29o 118 25 in in IN cord-324054-d71rj29o 118 26 heterologous heterologous JJ cord-324054-d71rj29o 118 27 hosts host NNS cord-324054-d71rj29o 118 28 . . . cord-324054-d71rj29o 119 1 However however RB cord-324054-d71rj29o 119 2 , , , cord-324054-d71rj29o 119 3 HCV HCV NNP cord-324054-d71rj29o 119 4 - - HYPH cord-324054-d71rj29o 119 5 OC43 OC43 NNP cord-324054-d71rj29o 119 6 primarily primarily RB cord-324054-d71rj29o 119 7 causes cause VBZ cord-324054-d71rj29o 119 8 respiratory respiratory JJ cord-324054-d71rj29o 119 9 diseases disease NNS cord-324054-d71rj29o 119 10 and and CC cord-324054-d71rj29o 119 11 BCVs bcv NNS cord-324054-d71rj29o 119 12 cause cause VBP cord-324054-d71rj29o 119 13 enteritis enteritis NN cord-324054-d71rj29o 119 14 . . . cord-324054-d71rj29o 120 1 The the DT cord-324054-d71rj29o 120 2 ability ability NN cord-324054-d71rj29o 120 3 of of IN cord-324054-d71rj29o 120 4 these these DT cord-324054-d71rj29o 120 5 viruses virus NNS cord-324054-d71rj29o 120 6 to to TO cord-324054-d71rj29o 120 7 replicate replicate VB cord-324054-d71rj29o 120 8 in in IN cord-324054-d71rj29o 120 9 different different JJ cord-324054-d71rj29o 120 10 organs organ NNS cord-324054-d71rj29o 120 11 and and CC cord-324054-d71rj29o 120 12 to to TO cord-324054-d71rj29o 120 13 cause cause VB cord-324054-d71rj29o 120 14 different different JJ cord-324054-d71rj29o 120 15 clinical clinical JJ cord-324054-d71rj29o 120 16 symptoms symptom NNS cord-324054-d71rj29o 120 17 is be VBZ cord-324054-d71rj29o 120 18 probably probably RB cord-324054-d71rj29o 120 19 due due JJ cord-324054-d71rj29o 120 20 to to IN cord-324054-d71rj29o 120 21 multiple multiple JJ cord-324054-d71rj29o 120 22 amino amino NN cord-324054-d71rj29o 120 23 acid acid NN cord-324054-d71rj29o 120 24 differences difference NNS cord-324054-d71rj29o 120 25 occurring occur VBG cord-324054-d71rj29o 120 26 within within IN cord-324054-d71rj29o 120 27 several several JJ cord-324054-d71rj29o 120 28 viral viral JJ cord-324054-d71rj29o 120 29 proteins protein NNS cord-324054-d71rj29o 120 30 . . . cord-324054-d71rj29o 121 1 The the DT cord-324054-d71rj29o 121 2 S S NNP cord-324054-d71rj29o 121 3 protein protein NN cord-324054-d71rj29o 121 4 of of IN cord-324054-d71rj29o 121 5 MHV MHV NNP cord-324054-d71rj29o 121 6 was be VBD cord-324054-d71rj29o 121 7 shown show VBN cord-324054-d71rj29o 121 8 to to TO cord-324054-d71rj29o 121 9 be be VB cord-324054-d71rj29o 121 10 important important JJ cord-324054-d71rj29o 121 11 in in IN cord-324054-d71rj29o 121 12 tissue tissue NN cord-324054-d71rj29o 121 13 tropism tropism NN cord-324054-d71rj29o 121 14 ( ( -LRB- cord-324054-d71rj29o 121 15 39 39 CD cord-324054-d71rj29o 121 16 ) ) -RRB- cord-324054-d71rj29o 121 17 . . . cord-324054-d71rj29o 122 1 Recently recently RB cord-324054-d71rj29o 122 2 , , , cord-324054-d71rj29o 122 3 it -PRON- PRP cord-324054-d71rj29o 122 4 was be VBD cord-324054-d71rj29o 122 5 reported report VBN cord-324054-d71rj29o 122 6 that that IN cord-324054-d71rj29o 122 7 turkey turkey NN cord-324054-d71rj29o 122 8 enteric enteric JJ cord-324054-d71rj29o 122 9 coronavirus coronavirus NN cord-324054-d71rj29o 122 10 is be VBZ cord-324054-d71rj29o 122 11 antigenically antigenically NN cord-324054-d71rj29o 122 12 and and CC cord-324054-d71rj29o 122 13 genomically genomically RB cord-324054-d71rj29o 122 14 closely closely RB cord-324054-d71rj29o 122 15 related relate VBN cord-324054-d71rj29o 122 16 to to IN cord-324054-d71rj29o 122 17 BCVs bcv NNS cord-324054-d71rj29o 122 18 ( ( -LRB- cord-324054-d71rj29o 122 19 40 40 CD cord-324054-d71rj29o 122 20 ) ) -RRB- cord-324054-d71rj29o 122 21 and and CC cord-324054-d71rj29o 122 22 similar similar JJ cord-324054-d71rj29o 122 23 functions function NNS cord-324054-d71rj29o 122 24 were be VBD cord-324054-d71rj29o 122 25 found find VBN cord-324054-d71rj29o 122 26 in in IN cord-324054-d71rj29o 122 27 the the DT cord-324054-d71rj29o 122 28 HE HE NNP cord-324054-d71rj29o 122 29 protein protein NN cord-324054-d71rj29o 122 30 of of IN cord-324054-d71rj29o 122 31 HEV HEV NNP cord-324054-d71rj29o 122 32 ( ( -LRB- cord-324054-d71rj29o 122 33 20 20 CD cord-324054-d71rj29o 122 34 ) ) -RRB- cord-324054-d71rj29o 122 35 . . . cord-324054-d71rj29o 123 1 Whether whether IN cord-324054-d71rj29o 123 2 swines swine NNS cord-324054-d71rj29o 123 3 or or CC cord-324054-d71rj29o 123 4 turkeys turkey NNS cord-324054-d71rj29o 123 5 may may MD cord-324054-d71rj29o 123 6 also also RB cord-324054-d71rj29o 123 7 serve serve VB cord-324054-d71rj29o 123 8 as as IN cord-324054-d71rj29o 123 9 reservoir reservoir NN cord-324054-d71rj29o 123 10 ( ( -LRB- cord-324054-d71rj29o 123 11 mixing mix VBG cord-324054-d71rj29o 123 12 - - HYPH cord-324054-d71rj29o 123 13 vessel vessel NN cord-324054-d71rj29o 123 14 ) ) -RRB- cord-324054-d71rj29o 123 15 for for IN cord-324054-d71rj29o 123 16 coronavirus coronavirus NN cord-324054-d71rj29o 123 17 recombination recombination NN cord-324054-d71rj29o 123 18 in in IN cord-324054-d71rj29o 123 19 nature nature NN cord-324054-d71rj29o 123 20 , , , cord-324054-d71rj29o 123 21 as as IN cord-324054-d71rj29o 123 22 it -PRON- PRP cord-324054-d71rj29o 123 23 was be VBD cord-324054-d71rj29o 123 24 proposed propose VBN cord-324054-d71rj29o 123 25 for for IN cord-324054-d71rj29o 123 26 influenza influenza NN cord-324054-d71rj29o 123 27 A a DT cord-324054-d71rj29o 123 28 viruses virus NNS cord-324054-d71rj29o 123 29 ( ( -LRB- cord-324054-d71rj29o 123 30 41 41 CD cord-324054-d71rj29o 123 31 ) ) -RRB- cord-324054-d71rj29o 123 32 remains remain VBZ cord-324054-d71rj29o 123 33 to to TO cord-324054-d71rj29o 123 34 be be VB cord-324054-d71rj29o 123 35 elucidated elucidate VBN cord-324054-d71rj29o 123 36 . . . cord-324054-d71rj29o 124 1 It -PRON- PRP cord-324054-d71rj29o 124 2 is be VBZ cord-324054-d71rj29o 124 3 worth worth JJ cord-324054-d71rj29o 124 4 noting note VBG cord-324054-d71rj29o 124 5 that that IN cord-324054-d71rj29o 124 6 ICV ICV NNP cord-324054-d71rj29o 124 7 was be VBD cord-324054-d71rj29o 124 8 also also RB cord-324054-d71rj29o 124 9 isolated isolate VBN cord-324054-d71rj29o 124 10 from from IN cord-324054-d71rj29o 124 11 pigs pig NNS cord-324054-d71rj29o 124 12 ( ( -LRB- cord-324054-d71rj29o 124 13 42 42 CD cord-324054-d71rj29o 124 14 ) ) -RRB- cord-324054-d71rj29o 124 15 . . . cord-324054-d71rj29o 125 1 It -PRON- PRP cord-324054-d71rj29o 125 2 will will MD cord-324054-d71rj29o 125 3 be be VB cord-324054-d71rj29o 125 4 worthwhile worthwhile JJ cord-324054-d71rj29o 125 5 to to TO cord-324054-d71rj29o 125 6 compare compare VB cord-324054-d71rj29o 125 7 the the DT cord-324054-d71rj29o 125 8 HE HE NNP cord-324054-d71rj29o 125 9 genes gene NNS cord-324054-d71rj29o 125 10 among among IN cord-324054-d71rj29o 125 11 these these DT cord-324054-d71rj29o 125 12 coronaviruses coronaviruse NNS cord-324054-d71rj29o 125 13 . . . cord-324054-d71rj29o 126 1 Comparison comparison NN cord-324054-d71rj29o 126 2 of of IN cord-324054-d71rj29o 126 3 the the DT cord-324054-d71rj29o 126 4 remaining remain VBG cord-324054-d71rj29o 126 5 genes gene NNS cord-324054-d71rj29o 126 6 with with IN cord-324054-d71rj29o 126 7 HCV HCV NNP cord-324054-d71rj29o 126 8 - - HYPH cord-324054-d71rj29o 126 9 OC43 OC43 NNP cord-324054-d71rj29o 126 10 and and CC cord-324054-d71rj29o 126 11 BCVs bcv NNS cord-324054-d71rj29o 126 12 will will MD cord-324054-d71rj29o 126 13 provide provide VB cord-324054-d71rj29o 126 14 further further JJ cord-324054-d71rj29o 126 15 insight insight NN cord-324054-d71rj29o 126 16 into into IN cord-324054-d71rj29o 126 17 their -PRON- PRP$ cord-324054-d71rj29o 126 18 evolution evolution NN cord-324054-d71rj29o 126 19 and and CC cord-324054-d71rj29o 126 20 host host NN cord-324054-d71rj29o 126 21 cell cell NN cord-324054-d71rj29o 126 22 tropism tropism NN cord-324054-d71rj29o 126 23 . . . cord-324054-d71rj29o 126 24 _SP cord-324054-d71rj29o 127 1 Proc proc VB cord-324054-d71rj29o 127 2 . . . cord-324054-d71rj29o 128 1 Nat/. Nat/. NNP cord-324054-d71rj29o 128 2 Acad Acad NNP cord-324054-d71rj29o 128 3 . . . cord-324054-d71rj29o 129 1 Sci Sci NNP cord-324054-d71rj29o 129 2 . . NNP cord-324054-d71rj29o 129 3 USA USA NNP cord-324054-d71rj29o 129 4 Proc Proc NNP cord-324054-d71rj29o 129 5 . . . cord-324054-d71rj29o 130 1 Nat/. Nat/. NNP cord-324054-d71rj29o 130 2 Acad Acad NNP cord-324054-d71rj29o 130 3 . . . cord-324054-d71rj29o 131 1 Sci Sci NNP cord-324054-d71rj29o 131 2 . . NNP cord-324054-d71rj29o 131 3 USA USA NNP