id	sid	tid	token	lemma	pos
cord-334133-61om170g	1	1	key	key	JJ
cord-334133-61om170g	1	2	:	:	:
cord-334133-61om170g	1	3	cord-334133	cord-334133	CD
cord-334133-61om170g	1	4	-	-	HYPH
cord-334133-61om170g	1	5	61om170	61om170	CD
cord-334133-61om170g	2	1	g	g	NNP
cord-334133-61om170g	2	2	authors	author	NNS
cord-334133-61om170g	2	3	:	:	:
cord-334133-61om170g	2	4	Hollier	Hollier	NNP
cord-334133-61om170g	2	5	,	,	,
cord-334133-61om170g	2	6	Mark	Mark	NNP
cord-334133-61om170g	2	7	J.	J.	NNP
cord-334133-61om170g	2	8	;	;	:
cord-334133-61om170g	2	9	Dimmock	Dimmock	NNP
cord-334133-61om170g	2	10	,	,	,
cord-334133-61om170g	2	11	Nigel	Nigel	NNP
cord-334133-61om170g	2	12	J.	J.	NNP
cord-334133-61om170g	2	13	title	title	NN
cord-334133-61om170g	2	14	:	:	:
cord-334133-61om170g	2	15	The	the	DT
cord-334133-61om170g	2	16	C	c	NN
cord-334133-61om170g	2	17	-	-	HYPH
cord-334133-61om170g	2	18	terminal	terminal	NN
cord-334133-61om170g	2	19	tail	tail	NN
cord-334133-61om170g	2	20	of	of	IN
cord-334133-61om170g	2	21	the	the	DT
cord-334133-61om170g	2	22	gp41	gp41	NNP
cord-334133-61om170g	2	23	transmembrane	transmembrane	NN
cord-334133-61om170g	2	24	envelope	envelope	NN
cord-334133-61om170g	2	25	glycoprotein	glycoprotein	NN
cord-334133-61om170g	2	26	of	of	IN
cord-334133-61om170g	3	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	3	2	clades	clade	NNS
cord-334133-61om170g	3	3	A	A	NNP
cord-334133-61om170g	3	4	,	,	,
cord-334133-61om170g	3	5	B	b	NN
cord-334133-61om170g	3	6	,	,	,
cord-334133-61om170g	3	7	C	C	NNP
cord-334133-61om170g	3	8	,	,	,
cord-334133-61om170g	3	9	and	and	CC
cord-334133-61om170g	3	10	D	D	NNP
cord-334133-61om170g	3	11	may	may	MD
cord-334133-61om170g	3	12	exist	exist	VB
cord-334133-61om170g	3	13	in	in	IN
cord-334133-61om170g	3	14	two	two	CD
cord-334133-61om170g	3	15	conformations	conformation	NNS
cord-334133-61om170g	3	16	:	:	:
cord-334133-61om170g	3	17	an	an	DT
cord-334133-61om170g	3	18	analysis	analysis	NN
cord-334133-61om170g	3	19	of	of	IN
cord-334133-61om170g	3	20	sequence	sequence	NN
cord-334133-61om170g	3	21	,	,	,
cord-334133-61om170g	3	22	structure	structure	NN
cord-334133-61om170g	3	23	,	,	,
cord-334133-61om170g	3	24	and	and	CC
cord-334133-61om170g	3	25	function	function	NN
cord-334133-61om170g	3	26	date	date	NN
cord-334133-61om170g	3	27	:	:	:
cord-334133-61om170g	3	28	2005	2005	CD
cord-334133-61om170g	3	29	-	-	HYPH
cord-334133-61om170g	3	30	07	07	CD
cord-334133-61om170g	3	31	-	-	HYPH
cord-334133-61om170g	3	32	05	05	CD
cord-334133-61om170g	3	33	journal	journal	NN
cord-334133-61om170g	3	34	:	:	:
cord-334133-61om170g	3	35	Virology	Virology	NNP
cord-334133-61om170g	3	36	DOI	DOI	NNP
cord-334133-61om170g	3	37	:	:	:
cord-334133-61om170g	3	38	10.1016	10.1016	CD
cord-334133-61om170g	3	39	/	/	SYM
cord-334133-61om170g	3	40	j.virol.2005.04.015	j.virol.2005.04.015	NNP
cord-334133-61om170g	3	41	sha	sha	NN
cord-334133-61om170g	3	42	:	:	:
cord-334133-61om170g	3	43	253c5b15ac4288e8a239ae6c93b8f0d3a7baa6cd	253c5b15ac4288e8a239ae6c93b8f0d3a7baa6cd	NNP
cord-334133-61om170g	3	44	doc_id	doc_id	CD
cord-334133-61om170g	3	45	:	:	:
cord-334133-61om170g	3	46	334133	334133	CD
cord-334133-61om170g	3	47	cord_uid	cord_uid	NNS
cord-334133-61om170g	3	48	:	:	:
cord-334133-61om170g	4	1	61om170	61om170	CD
cord-334133-61om170g	5	1	g	g	NNP
cord-334133-61om170g	6	1	In	in	IN
cord-334133-61om170g	6	2	addition	addition	NN
cord-334133-61om170g	6	3	to	to	IN
cord-334133-61om170g	6	4	the	the	DT
cord-334133-61om170g	6	5	major	major	JJ
cord-334133-61om170g	6	6	ectodomain	ectodomain	NN
cord-334133-61om170g	6	7	,	,	,
cord-334133-61om170g	6	8	the	the	DT
cord-334133-61om170g	6	9	gp41	gp41	NNP
cord-334133-61om170g	6	10	transmembrane	transmembrane	NN
cord-334133-61om170g	6	11	glycoprotein	glycoprotein	NN
cord-334133-61om170g	6	12	of	of	IN
cord-334133-61om170g	6	13	HIV-1	HIV-1	NNP
cord-334133-61om170g	6	14	is	be	VBZ
cord-334133-61om170g	6	15	now	now	RB
cord-334133-61om170g	6	16	known	know	VBN
cord-334133-61om170g	6	17	to	to	TO
cord-334133-61om170g	6	18	have	have	VB
cord-334133-61om170g	6	19	a	a	DT
cord-334133-61om170g	6	20	minor	minor	JJ
cord-334133-61om170g	6	21	ectodomain	ectodomain	NN
cord-334133-61om170g	6	22	that	that	WDT
cord-334133-61om170g	6	23	is	be	VBZ
cord-334133-61om170g	6	24	part	part	NN
cord-334133-61om170g	6	25	of	of	IN
cord-334133-61om170g	6	26	the	the	DT
cord-334133-61om170g	6	27	long	long	JJ
cord-334133-61om170g	6	28	C	c	NN
cord-334133-61om170g	6	29	-	-	HYPH
cord-334133-61om170g	6	30	terminal	terminal	NN
cord-334133-61om170g	6	31	tail	tail	NN
cord-334133-61om170g	6	32	.	.	.
cord-334133-61om170g	7	1	Both	both	DT
cord-334133-61om170g	7	2	ectodomains	ectodomain	NNS
cord-334133-61om170g	7	3	are	be	VBP
cord-334133-61om170g	7	4	highly	highly	RB
cord-334133-61om170g	7	5	antigenic	antigenic	JJ
cord-334133-61om170g	7	6	,	,	,
cord-334133-61om170g	7	7	carry	carry	VBP
cord-334133-61om170g	7	8	neutralizing	neutralize	VBG
cord-334133-61om170g	7	9	and	and	CC
cord-334133-61om170g	7	10	non	non	JJ
cord-334133-61om170g	7	11	-	-	JJ
cord-334133-61om170g	7	12	neutralizing	neutralizing	JJ
cord-334133-61om170g	7	13	epitopes	epitope	NNS
cord-334133-61om170g	7	14	,	,	,
cord-334133-61om170g	7	15	and	and	CC
cord-334133-61om170g	7	16	are	be	VBP
cord-334133-61om170g	7	17	involved	involve	VBN
cord-334133-61om170g	7	18	in	in	IN
cord-334133-61om170g	7	19	virus	virus	NN
cord-334133-61om170g	7	20	-	-	HYPH
cord-334133-61om170g	7	21	mediated	mediate	VBN
cord-334133-61om170g	7	22	fusion	fusion	NN
cord-334133-61om170g	7	23	activity	activity	NN
cord-334133-61om170g	7	24	.	.	.
cord-334133-61om170g	8	1	However	however	RB
cord-334133-61om170g	8	2	,	,	,
cord-334133-61om170g	8	3	data	datum	NNS
cord-334133-61om170g	8	4	have	have	VBP
cord-334133-61om170g	8	5	so	so	RB
cord-334133-61om170g	8	6	far	far	RB
cord-334133-61om170g	8	7	been	be	VBN
cord-334133-61om170g	8	8	biologically	biologically	RB
cord-334133-61om170g	8	9	based	base	VBN
cord-334133-61om170g	8	10	,	,	,
cord-334133-61om170g	8	11	and	and	CC
cord-334133-61om170g	8	12	derived	derive	VBN
cord-334133-61om170g	8	13	solely	solely	RB
cord-334133-61om170g	8	14	from	from	IN
cord-334133-61om170g	8	15	T	T	NNP
cord-334133-61om170g	8	16	cell	cell	NN
cord-334133-61om170g	8	17	line	line	NN
cord-334133-61om170g	8	18	-	-	HYPH
cord-334133-61om170g	8	19	adapted	adapt	VBN
cord-334133-61om170g	8	20	(	(	-LRB-
cord-334133-61om170g	8	21	TCLA	TCLA	NNP
cord-334133-61om170g	8	22	)	)	-RRB-
cord-334133-61om170g	8	23	,	,	,
cord-334133-61om170g	8	24	B	b	NN
cord-334133-61om170g	8	25	clade	clade	NN
cord-334133-61om170g	8	26	viruses	virus	NNS
cord-334133-61om170g	8	27	.	.	.
cord-334133-61om170g	9	1	Here	here	RB
cord-334133-61om170g	9	2	we	-PRON-	PRP
cord-334133-61om170g	9	3	have	have	VBP
cord-334133-61om170g	9	4	carried	carry	VBN
cord-334133-61om170g	9	5	out	out	RP
cord-334133-61om170g	9	6	sequence	sequence	NN
cord-334133-61om170g	9	7	and	and	CC
cord-334133-61om170g	9	8	theoretically	theoretically	RB
cord-334133-61om170g	9	9	based	base	VBN
cord-334133-61om170g	9	10	structural	structural	JJ
cord-334133-61om170g	9	11	analyses	analysis	NNS
cord-334133-61om170g	9	12	of	of	IN
cord-334133-61om170g	9	13	357	357	CD
cord-334133-61om170g	9	14	gp41	gp41	NNP
cord-334133-61om170g	9	15	C	c	NN
cord-334133-61om170g	9	16	-	-	HYPH
cord-334133-61om170g	9	17	terminal	terminal	NN
cord-334133-61om170g	9	18	sequences	sequence	NNS
cord-334133-61om170g	9	19	of	of	IN
cord-334133-61om170g	9	20	mainly	mainly	RB
cord-334133-61om170g	9	21	primary	primary	JJ
cord-334133-61om170g	9	22	isolates	isolate	NNS
cord-334133-61om170g	9	23	of	of	IN
cord-334133-61om170g	10	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	10	2	clades	clade	NNS
cord-334133-61om170g	10	3	A	A	NNP
cord-334133-61om170g	10	4	,	,	,
cord-334133-61om170g	10	5	B	b	NN
cord-334133-61om170g	10	6	,	,	,
cord-334133-61om170g	10	7	C	C	NNP
cord-334133-61om170g	10	8	,	,	,
cord-334133-61om170g	10	9	and	and	CC
cord-334133-61om170g	10	10	D.	D.	NNP
cord-334133-61om170g	10	11	Data	Data	NNP
cord-334133-61om170g	10	12	show	show	VBP
cord-334133-61om170g	10	13	that	that	IN
cord-334133-61om170g	10	14	all	all	PDT
cord-334133-61om170g	10	15	these	these	DT
cord-334133-61om170g	10	16	viruses	virus	NNS
cord-334133-61om170g	10	17	have	have	VBP
cord-334133-61om170g	10	18	the	the	DT
cord-334133-61om170g	10	19	potential	potential	NN
cord-334133-61om170g	10	20	to	to	TO
cord-334133-61om170g	10	21	form	form	VB
cord-334133-61om170g	10	22	a	a	DT
cord-334133-61om170g	10	23	tail	tail	NN
cord-334133-61om170g	10	24	loop	loop	NN
cord-334133-61om170g	10	25	structure	structure	NN
cord-334133-61om170g	10	26	(	(	-LRB-
cord-334133-61om170g	10	27	the	the	DT
cord-334133-61om170g	10	28	minor	minor	JJ
cord-334133-61om170g	10	29	ectodomain	ectodomain	NN
cord-334133-61om170g	10	30	)	)	-RRB-
cord-334133-61om170g	10	31	supported	support	VBN
cord-334133-61om170g	10	32	by	by	IN
cord-334133-61om170g	10	33	three	three	CD
cord-334133-61om170g	10	34	,	,	,
cord-334133-61om170g	10	35	β	β	NN
cord-334133-61om170g	10	36	-	-	HYPH
cord-334133-61om170g	10	37	sheet	sheet	NN
cord-334133-61om170g	10	38	,	,	,
cord-334133-61om170g	10	39	membrane	membrane	NN
cord-334133-61om170g	10	40	-	-	HYPH
cord-334133-61om170g	10	41	spanning	span	VBG
cord-334133-61om170g	10	42	domains	domain	NNS
cord-334133-61om170g	10	43	(	(	-LRB-
cord-334133-61om170g	10	44	MSDs	MSDs	NNP
cord-334133-61om170g	10	45	)	)	-RRB-
cord-334133-61om170g	10	46	.	.	.
cord-334133-61om170g	11	1	This	this	DT
cord-334133-61om170g	11	2	means	mean	VBZ
cord-334133-61om170g	11	3	that	that	IN
cord-334133-61om170g	11	4	the	the	DT
cord-334133-61om170g	11	5	first	first	JJ
cord-334133-61om170g	11	6	(	(	-LRB-
cord-334133-61om170g	11	7	N	n	CD
cord-334133-61om170g	11	8	-	-	HYPH
cord-334133-61om170g	11	9	terminal	terminal	NN
cord-334133-61om170g	11	10	)	)	-RRB-
cord-334133-61om170g	11	11	tyrosine	tyrosine	NN
cord-334133-61om170g	11	12	-	-	HYPH
cord-334133-61om170g	11	13	based	base	VBN
cord-334133-61om170g	11	14	sorting	sorting	NN
cord-334133-61om170g	11	15	signal	signal	NN
cord-334133-61om170g	11	16	of	of	IN
cord-334133-61om170g	11	17	the	the	DT
cord-334133-61om170g	11	18	gp41	gp41	NNP
cord-334133-61om170g	11	19	tail	tail	NN
cord-334133-61om170g	11	20	is	be	VBZ
cord-334133-61om170g	11	21	situated	situate	VBN
cord-334133-61om170g	11	22	outside	outside	IN
cord-334133-61om170g	11	23	the	the	DT
cord-334133-61om170g	11	24	cell	cell	NN
cord-334133-61om170g	11	25	membrane	membrane	NN
cord-334133-61om170g	11	26	and	and	CC
cord-334133-61om170g	11	27	is	be	VBZ
cord-334133-61om170g	11	28	non	non	JJ
cord-334133-61om170g	11	29	-	-	JJ
cord-334133-61om170g	11	30	functional	functional	JJ
cord-334133-61om170g	11	31	,	,	,
cord-334133-61om170g	11	32	and	and	CC
cord-334133-61om170g	11	33	that	that	DT
cord-334133-61om170g	11	34	gp41	gp41	NNP
cord-334133-61om170g	11	35	that	that	WDT
cord-334133-61om170g	11	36	reaches	reach	VBZ
cord-334133-61om170g	11	37	the	the	DT
cord-334133-61om170g	11	38	cell	cell	NN
cord-334133-61om170g	11	39	surface	surface	NN
cord-334133-61om170g	11	40	may	may	MD
cord-334133-61om170g	11	41	be	be	VB
cord-334133-61om170g	11	42	recycled	recycle	VBN
cord-334133-61om170g	11	43	back	back	RB
cord-334133-61om170g	11	44	into	into	IN
cord-334133-61om170g	11	45	the	the	DT
cord-334133-61om170g	11	46	cytoplasm	cytoplasm	NN
cord-334133-61om170g	11	47	through	through	IN
cord-334133-61om170g	11	48	the	the	DT
cord-334133-61om170g	11	49	activity	activity	NN
cord-334133-61om170g	11	50	of	of	IN
cord-334133-61om170g	11	51	the	the	DT
cord-334133-61om170g	11	52	second	second	JJ
cord-334133-61om170g	11	53	tyrosine	tyrosine	NN
cord-334133-61om170g	11	54	-	-	HYPH
cord-334133-61om170g	11	55	sorting	sort	VBG
cord-334133-61om170g	11	56	signal	signal	NN
cord-334133-61om170g	11	57	.	.	.
cord-334133-61om170g	12	1	However	however	RB
cord-334133-61om170g	12	2	,	,	,
cord-334133-61om170g	12	3	we	-PRON-	PRP
cord-334133-61om170g	12	4	suggest	suggest	VBP
cord-334133-61om170g	12	5	that	that	IN
cord-334133-61om170g	12	6	only	only	RB
cord-334133-61om170g	12	7	a	a	DT
cord-334133-61om170g	12	8	minority	minority	NN
cord-334133-61om170g	12	9	of	of	IN
cord-334133-61om170g	12	10	cell	cell	NN
cord-334133-61om170g	12	11	-	-	HYPH
cord-334133-61om170g	12	12	associated	associate	VBN
cord-334133-61om170g	12	13	gp41	gp41	NNP
cord-334133-61om170g	12	14	molecules	molecule	NNS
cord-334133-61om170g	12	15	–	–	:
cord-334133-61om170g	12	16	those	those	DT
cord-334133-61om170g	12	17	destined	destine	VBN
cord-334133-61om170g	12	18	for	for	IN
cord-334133-61om170g	12	19	incorporation	incorporation	NN
cord-334133-61om170g	12	20	into	into	IN
cord-334133-61om170g	12	21	virions	virion	NNS
cord-334133-61om170g	12	22	–	–	:
cord-334133-61om170g	12	23	has	have	VBZ
cord-334133-61om170g	12	24	3	3	CD
cord-334133-61om170g	12	25	MSDs	msd	NNS
cord-334133-61om170g	12	26	and	and	CC
cord-334133-61om170g	12	27	the	the	DT
cord-334133-61om170g	12	28	minor	minor	JJ
cord-334133-61om170g	12	29	ectodomain	ectodomain	NN
cord-334133-61om170g	12	30	.	.	.
cord-334133-61om170g	13	1	Most	most	RBS
cord-334133-61om170g	13	2	intracellular	intracellular	JJ
cord-334133-61om170g	13	3	gp41	gp41	NNP
cord-334133-61om170g	13	4	has	have	VBZ
cord-334133-61om170g	13	5	the	the	DT
cord-334133-61om170g	13	6	conventional	conventional	JJ
cord-334133-61om170g	13	7	single	single	JJ
cord-334133-61om170g	13	8	MSD	msd	NN
cord-334133-61om170g	13	9	,	,	,
cord-334133-61om170g	13	10	no	no	DT
cord-334133-61om170g	13	11	minor	minor	JJ
cord-334133-61om170g	13	12	ectodomain	ectodomain	NN
cord-334133-61om170g	13	13	,	,	,
cord-334133-61om170g	13	14	a	a	DT
cord-334133-61om170g	13	15	functional	functional	JJ
cord-334133-61om170g	13	16	first	first	JJ
cord-334133-61om170g	13	17	tyrosine	tyrosine	NN
cord-334133-61om170g	13	18	-	-	HYPH
cord-334133-61om170g	13	19	based	base	VBN
cord-334133-61om170g	13	20	sorting	sorting	NN
cord-334133-61om170g	13	21	signal	signal	NN
cord-334133-61om170g	13	22	,	,	,
cord-334133-61om170g	13	23	and	and	CC
cord-334133-61om170g	13	24	in	in	IN
cord-334133-61om170g	13	25	line	line	NN
cord-334133-61om170g	13	26	with	with	IN
cord-334133-61om170g	13	27	current	current	JJ
cord-334133-61om170g	13	28	thinking	thinking	NN
cord-334133-61om170g	13	29	is	be	VBZ
cord-334133-61om170g	13	30	degraded	degrade	VBN
cord-334133-61om170g	13	31	intracellularly	intracellularly	RB
cord-334133-61om170g	13	32	.	.	.
cord-334133-61om170g	14	1	The	the	DT
cord-334133-61om170g	14	2	gp41	gp41	NNP
cord-334133-61om170g	14	3	structural	structural	JJ
cord-334133-61om170g	14	4	diversity	diversity	NN
cord-334133-61om170g	14	5	suggested	suggest	VBD
cord-334133-61om170g	14	6	here	here	RB
cord-334133-61om170g	14	7	can	can	MD
cord-334133-61om170g	14	8	be	be	VB
cord-334133-61om170g	14	9	viewed	view	VBN
cord-334133-61om170g	14	10	as	as	IN
cord-334133-61om170g	14	11	an	an	DT
cord-334133-61om170g	14	12	evolutionary	evolutionary	JJ
cord-334133-61om170g	14	13	strategy	strategy	NN
cord-334133-61om170g	14	14	to	to	TO
cord-334133-61om170g	14	15	minimize	minimize	VB
cord-334133-61om170g	14	16	HIV-1	HIV-1	NNP
cord-334133-61om170g	14	17	envelope	envelope	NN
cord-334133-61om170g	14	18	glycoprotein	glycoprotein	NN
cord-334133-61om170g	14	19	expression	expression	NN
cord-334133-61om170g	14	20	on	on	IN
cord-334133-61om170g	14	21	the	the	DT
cord-334133-61om170g	14	22	cell	cell	NN
cord-334133-61om170g	14	23	surface	surface	NN
cord-334133-61om170g	14	24	,	,	,
cord-334133-61om170g	14	25	and	and	CC
cord-334133-61om170g	14	26	hence	hence	RB
cord-334133-61om170g	14	27	possible	possible	JJ
cord-334133-61om170g	14	28	cytotoxicity	cytotoxicity	NN
cord-334133-61om170g	14	29	and	and	CC
cord-334133-61om170g	14	30	immune	immune	JJ
cord-334133-61om170g	14	31	attack	attack	NN
cord-334133-61om170g	14	32	on	on	IN
cord-334133-61om170g	14	33	the	the	DT
cord-334133-61om170g	14	34	infected	infected	JJ
cord-334133-61om170g	14	35	cell	cell	NN
cord-334133-61om170g	14	36	.	.	.
cord-334133-61om170g	15	1	Viruses	virus	NNS
cord-334133-61om170g	15	2	of	of	IN
cord-334133-61om170g	15	3	the	the	DT
cord-334133-61om170g	15	4	Lentivirus	Lentivirus	NNP
cord-334133-61om170g	15	5	genus	genus	NN
cord-334133-61om170g	15	6	of	of	IN
cord-334133-61om170g	15	7	the	the	DT
cord-334133-61om170g	15	8	Retroviridae	Retroviridae	NNP
cord-334133-61om170g	15	9	have	have	VBP
cord-334133-61om170g	15	10	a	a	DT
cord-334133-61om170g	15	11	single	single	JJ
cord-334133-61om170g	15	12	virus	virus	NN
cord-334133-61om170g	15	13	-	-	HYPH
cord-334133-61om170g	15	14	encoded	encode	VBN
cord-334133-61om170g	15	15	,	,	,
cord-334133-61om170g	15	16	envelope	envelope	NN
cord-334133-61om170g	15	17	glycoprotein	glycoprotein	NN
cord-334133-61om170g	15	18	(	(	-LRB-
cord-334133-61om170g	15	19	Env	Env	NNP
cord-334133-61om170g	15	20	)	)	-RRB-
cord-334133-61om170g	15	21	.	.	.
cord-334133-61om170g	16	1	This	this	DT
cord-334133-61om170g	16	2	is	be	VBZ
cord-334133-61om170g	16	3	a	a	DT
cord-334133-61om170g	16	4	type	type	NN
cord-334133-61om170g	16	5	I	-PRON-	PRP
cord-334133-61om170g	16	6	membrane	membrane	VBP
cord-334133-61om170g	16	7	protein	protein	NN
cord-334133-61om170g	16	8	with	with	IN
cord-334133-61om170g	16	9	the	the	DT
cord-334133-61om170g	16	10	N	n	CD
cord-334133-61om170g	16	11	-	-	HYPH
cord-334133-61om170g	16	12	terminus	terminus	NN
cord-334133-61om170g	16	13	on	on	IN
cord-334133-61om170g	16	14	the	the	DT
cord-334133-61om170g	16	15	outside	outside	NN
cord-334133-61om170g	16	16	of	of	IN
cord-334133-61om170g	16	17	the	the	DT
cord-334133-61om170g	16	18	cell	cell	NN
cord-334133-61om170g	16	19	.	.	.
cord-334133-61om170g	17	1	Env	Env	NNP
cord-334133-61om170g	17	2	mRNA	mRNA	NNP
cord-334133-61om170g	17	3	is	be	VBZ
cord-334133-61om170g	17	4	synthesized	synthesize	VBN
cord-334133-61om170g	17	5	in	in	IN
cord-334133-61om170g	17	6	the	the	DT
cord-334133-61om170g	17	7	nucleus	nucleus	NN
cord-334133-61om170g	17	8	,	,	,
cord-334133-61om170g	17	9	and	and	CC
cord-334133-61om170g	17	10	exported	export	VBN
cord-334133-61om170g	17	11	with	with	IN
cord-334133-61om170g	17	12	the	the	DT
cord-334133-61om170g	17	13	help	help	NN
cord-334133-61om170g	17	14	of	of	IN
cord-334133-61om170g	17	15	the	the	DT
cord-334133-61om170g	17	16	viral	viral	JJ
cord-334133-61om170g	17	17	Rev	Rev	NNP
cord-334133-61om170g	17	18	protein	protein	NN
cord-334133-61om170g	17	19	to	to	IN
cord-334133-61om170g	17	20	the	the	DT
cord-334133-61om170g	17	21	cytoplasm	cytoplasm	NN
cord-334133-61om170g	17	22	where	where	WRB
cord-334133-61om170g	17	23	it	-PRON-	PRP
cord-334133-61om170g	17	24	is	be	VBZ
cord-334133-61om170g	17	25	translated	translate	VBN
cord-334133-61om170g	17	26	as	as	IN
cord-334133-61om170g	17	27	a	a	DT
cord-334133-61om170g	17	28	gp160	gp160	NNP
cord-334133-61om170g	17	29	precursor	precursor	NN
cord-334133-61om170g	17	30	.	.	.
cord-334133-61om170g	18	1	Gp160	Gp160	NNP
cord-334133-61om170g	18	2	is	be	VBZ
cord-334133-61om170g	18	3	then	then	RB
cord-334133-61om170g	18	4	translocated	translocate	VBN
cord-334133-61om170g	18	5	through	through	IN
cord-334133-61om170g	18	6	the	the	DT
cord-334133-61om170g	18	7	rough	rough	JJ
cord-334133-61om170g	18	8	endoplasmic	endoplasmic	NN
cord-334133-61om170g	18	9	reticulum	reticulum	NN
cord-334133-61om170g	18	10	(	(	-LRB-
cord-334133-61om170g	18	11	ER	ER	NNP
cord-334133-61om170g	18	12	)	)	-RRB-
cord-334133-61om170g	18	13	(	(	-LRB-
cord-334133-61om170g	18	14	Dettenhofer	Dettenhofer	NNP
cord-334133-61om170g	18	15	and	and	CC
cord-334133-61om170g	18	16	Yu	Yu	NNP
cord-334133-61om170g	18	17	,	,	,
cord-334133-61om170g	18	18	2001	2001	CD
cord-334133-61om170g	18	19	)	)	-RRB-
cord-334133-61om170g	18	20	,	,	,
cord-334133-61om170g	18	21	and	and	CC
cord-334133-61om170g	18	22	folded	fold	VBN
cord-334133-61om170g	18	23	with	with	IN
cord-334133-61om170g	18	24	the	the	DT
cord-334133-61om170g	18	25	assistance	assistance	NN
cord-334133-61om170g	18	26	of	of	IN
cord-334133-61om170g	18	27	the	the	DT
cord-334133-61om170g	18	28	chaperone	chaperone	NN
cord-334133-61om170g	18	29	proteins	protein	NNS
cord-334133-61om170g	18	30	,	,	,
cord-334133-61om170g	18	31	calreticulin	calreticulin	NNP
cord-334133-61om170g	18	32	,	,	,
cord-334133-61om170g	18	33	and	and	CC
cord-334133-61om170g	18	34	calnexin	calnexin	NNP
cord-334133-61om170g	18	35	(	(	-LRB-
cord-334133-61om170g	18	36	Otteken	Otteken	NNP
cord-334133-61om170g	18	37	et	et	NNP
cord-334133-61om170g	18	38	al	al	NNP
cord-334133-61om170g	18	39	.	.	NNP
cord-334133-61om170g	18	40	,	,	,
cord-334133-61om170g	18	41	1996	1996	CD
cord-334133-61om170g	18	42	)	)	-RRB-
cord-334133-61om170g	18	43	.	.	.
cord-334133-61om170g	19	1	Glycans	glycan	NNS
cord-334133-61om170g	19	2	are	be	VBP
cord-334133-61om170g	19	3	added	add	VBN
cord-334133-61om170g	19	4	in	in	IN
cord-334133-61om170g	19	5	the	the	DT
cord-334133-61om170g	19	6	Golgi	Golgi	NNP
cord-334133-61om170g	19	7	,	,	,
cord-334133-61om170g	19	8	and	and	CC
cord-334133-61om170g	19	9	subsequently	subsequently	RB
cord-334133-61om170g	19	10	trimmed	trim	VBN
cord-334133-61om170g	20	1	(	(	-LRB-
cord-334133-61om170g	20	2	Dash	Dash	NNP
cord-334133-61om170g	20	3	et	et	FW
cord-334133-61om170g	20	4	al	al	NNP
cord-334133-61om170g	20	5	.	.	NNP
cord-334133-61om170g	20	6	,	,	,
cord-334133-61om170g	20	7	1994	1994	CD
cord-334133-61om170g	20	8	;	;	:
cord-334133-61om170g	20	9	Fenouillet	Fenouillet	NNP
cord-334133-61om170g	20	10	and	and	CC
cord-334133-61om170g	20	11	Jones	Jones	NNP
cord-334133-61om170g	20	12	,	,	,
cord-334133-61om170g	20	13	1995	1995	CD
cord-334133-61om170g	20	14	)	)	-RRB-
cord-334133-61om170g	20	15	.	.	.
cord-334133-61om170g	21	1	Gp160	Gp160	NNP
cord-334133-61om170g	21	2	oligomerizes	oligomerizes	NNP
cord-334133-61om170g	21	3	in	in	IN
cord-334133-61om170g	21	4	the	the	DT
cord-334133-61om170g	21	5	ER	ER	NNP
cord-334133-61om170g	21	6	,	,	,
cord-334133-61om170g	21	7	forming	form	VBG
cord-334133-61om170g	21	8	a	a	DT
cord-334133-61om170g	21	9	non	non	NN
cord-334133-61om170g	21	10	-	-	JJ
cord-334133-61om170g	21	11	covalently	covalently	RB
cord-334133-61om170g	21	12	linked	link	VBN
cord-334133-61om170g	21	13	trimer	trimer	NN
cord-334133-61om170g	21	14	(	(	-LRB-
cord-334133-61om170g	21	15	Earl	Earl	NNP
cord-334133-61om170g	21	16	et	et	NNP
cord-334133-61om170g	21	17	al	al	NNP
cord-334133-61om170g	21	18	.	.	NNP
cord-334133-61om170g	21	19	,	,	,
cord-334133-61om170g	21	20	1991	1991	CD
cord-334133-61om170g	21	21	;	;	:
cord-334133-61om170g	22	1	Willey	Willey	NNP
cord-334133-61om170g	22	2	et	et	NNP
cord-334133-61om170g	22	3	al	al	NNP
cord-334133-61om170g	22	4	.	.	NNP
cord-334133-61om170g	22	5	,	,	,
cord-334133-61om170g	22	6	1988	1988	CD
cord-334133-61om170g	22	7	)	)	-RRB-
cord-334133-61om170g	22	8	.	.	.
cord-334133-61om170g	23	1	Most	Most	JJS
cord-334133-61om170g	23	2	gp160	gp160	NNP
cord-334133-61om170g	23	3	is	be	VBZ
cord-334133-61om170g	23	4	degraded	degrade	VBN
cord-334133-61om170g	23	5	,	,	,
cord-334133-61om170g	23	6	but	but	CC
cord-334133-61om170g	23	7	about	about	RB
cord-334133-61om170g	23	8	5	5	CD
cord-334133-61om170g	23	9	-	-	SYM
cord-334133-61om170g	23	10	15	15	CD
cord-334133-61om170g	23	11	%	%	NN
cord-334133-61om170g	23	12	is	be	VBZ
cord-334133-61om170g	23	13	cleaved	cleave	VBN
cord-334133-61om170g	23	14	into	into	IN
cord-334133-61om170g	23	15	gp120	gp120	NNP
cord-334133-61om170g	23	16	(	(	-LRB-
cord-334133-61om170g	23	17	distal	distal	JJ
cord-334133-61om170g	23	18	)	)	-RRB-
cord-334133-61om170g	23	19	and	and	CC
cord-334133-61om170g	23	20	gp41	gp41	NNP
cord-334133-61om170g	23	21	(	(	-LRB-
cord-334133-61om170g	23	22	membrane	membrane	NN
cord-334133-61om170g	23	23	anchor	anchor	NN
cord-334133-61om170g	23	24	)	)	-RRB-
cord-334133-61om170g	23	25	components	component	NNS
cord-334133-61om170g	23	26	.	.	.
cord-334133-61om170g	24	1	These	these	DT
cord-334133-61om170g	24	2	remain	remain	VBP
cord-334133-61om170g	24	3	associated	associated	JJ
cord-334133-61om170g	24	4	non	non	AFX
cord-334133-61om170g	24	5	-	-	JJ
cord-334133-61om170g	24	6	covalently	covalently	RB
cord-334133-61om170g	24	7	and	and	CC
cord-334133-61om170g	24	8	are	be	VBP
cord-334133-61om170g	24	9	targeted	target	VBN
cord-334133-61om170g	24	10	to	to	IN
cord-334133-61om170g	24	11	the	the	DT
cord-334133-61om170g	24	12	cell	cell	NN
cord-334133-61om170g	24	13	surface	surface	NN
cord-334133-61om170g	24	14	(	(	-LRB-
cord-334133-61om170g	24	15	see	see	VB
cord-334133-61om170g	24	16	below	below	RB
cord-334133-61om170g	24	17	)	)	-RRB-
cord-334133-61om170g	24	18	.	.	.
cord-334133-61om170g	25	1	Gp120-gp41	Gp120-gp41	NNP
cord-334133-61om170g	25	2	trimers	trimers	NNP
cord-334133-61om170g	25	3	are	be	VBP
cord-334133-61om170g	25	4	incorporated	incorporate	VBN
cord-334133-61om170g	25	5	into	into	IN
cord-334133-61om170g	25	6	progeny	progeny	JJ
cord-334133-61om170g	25	7	virions	virion	NNS
cord-334133-61om170g	25	8	.	.	.
cord-334133-61om170g	26	1	Gp120	Gp120	NNP
cord-334133-61om170g	26	2	can	can	MD
cord-334133-61om170g	26	3	be	be	VB
cord-334133-61om170g	26	4	shed	shed	VBN
cord-334133-61om170g	26	5	from	from	IN
cord-334133-61om170g	26	6	the	the	DT
cord-334133-61om170g	26	7	surface	surface	NN
cord-334133-61om170g	26	8	of	of	IN
cord-334133-61om170g	26	9	cells	cell	NNS
cord-334133-61om170g	26	10	and	and	CC
cord-334133-61om170g	26	11	virions	virion	NNS
cord-334133-61om170g	26	12	(	(	-LRB-
cord-334133-61om170g	26	13	Willey	Willey	NNP
cord-334133-61om170g	26	14	et	et	NNP
cord-334133-61om170g	26	15	al	al	NNP
cord-334133-61om170g	26	16	.	.	.
cord-334133-61om170g	27	1	,	,	,
cord-334133-61om170g	27	2	1988	1988	CD
cord-334133-61om170g	27	3	(	(	-LRB-
cord-334133-61om170g	27	4	Willey	Willey	NNP
cord-334133-61om170g	27	5	et	et	NNP
cord-334133-61om170g	27	6	al	al	NNP
cord-334133-61om170g	27	7	.	.	NNP
cord-334133-61om170g	27	8	,	,	,
cord-334133-61om170g	27	9	,	,	,
cord-334133-61om170g	27	10	1991	1991	CD
cord-334133-61om170g	27	11	.	.	.
cord-334133-61om170g	28	1	Enzymatic	enzymatic	JJ
cord-334133-61om170g	28	2	cleavage	cleavage	NN
cord-334133-61om170g	28	3	of	of	IN
cord-334133-61om170g	28	4	gp160	gp160	NN
cord-334133-61om170g	28	5	to	to	IN
cord-334133-61om170g	28	6	gp120-gp41	gp120-gp41	NNP
cord-334133-61om170g	28	7	is	be	VBZ
cord-334133-61om170g	28	8	essential	essential	JJ
cord-334133-61om170g	28	9	for	for	IN
cord-334133-61om170g	28	10	Env	Env	NNP
cord-334133-61om170g	28	11	function	function	NN
cord-334133-61om170g	28	12	.	.	.
cord-334133-61om170g	29	1	Uncleaved	uncleaved	JJ
cord-334133-61om170g	29	2	gp160	gp160	NNP
cord-334133-61om170g	29	3	can	can	MD
cord-334133-61om170g	29	4	not	not	RB
cord-334133-61om170g	29	5	induce	induce	VB
cord-334133-61om170g	29	6	syncytium	syncytium	NN
cord-334133-61om170g	29	7	formation	formation	NN
cord-334133-61om170g	29	8	,	,	,
cord-334133-61om170g	29	9	and	and	CC
cord-334133-61om170g	29	10	virions	virion	NNS
cord-334133-61om170g	29	11	with	with	IN
cord-334133-61om170g	29	12	uncleaved	uncleaved	JJ
cord-334133-61om170g	29	13	gp160	gp160	NNP
cord-334133-61om170g	29	14	are	be	VBP
cord-334133-61om170g	29	15	not	not	RB
cord-334133-61om170g	29	16	infectious	infectious	JJ
cord-334133-61om170g	29	17	.	.	.
cord-334133-61om170g	30	1	Gp160	Gp160	NNP
cord-334133-61om170g	30	2	is	be	VBZ
cord-334133-61om170g	30	3	rarely	rarely	RB
cord-334133-61om170g	30	4	incorporated	incorporate	VBN
cord-334133-61om170g	30	5	into	into	IN
cord-334133-61om170g	30	6	virions	virion	NNS
cord-334133-61om170g	30	7	,	,	,
cord-334133-61om170g	30	8	probably	probably	RB
cord-334133-61om170g	30	9	because	because	IN
cord-334133-61om170g	30	10	so	so	RB
cord-334133-61om170g	30	11	little	little	JJ
cord-334133-61om170g	30	12	reaches	reach	VBZ
cord-334133-61om170g	30	13	the	the	DT
cord-334133-61om170g	30	14	cell	cell	NN
cord-334133-61om170g	30	15	surface	surface	NN
cord-334133-61om170g	30	16	(	(	-LRB-
cord-334133-61om170g	30	17	Duensing	duensing	FW
cord-334133-61om170g	30	18	et	et	FW
cord-334133-61om170g	30	19	al	al	NNP
cord-334133-61om170g	30	20	.	.	NNP
cord-334133-61om170g	30	21	,	,	,
cord-334133-61om170g	30	22	1995	1995	CD
cord-334133-61om170g	30	23	;	;	:
cord-334133-61om170g	30	24	Pal	Pal	NNP
cord-334133-61om170g	30	25	et	et	FW
cord-334133-61om170g	30	26	al	al	NNP
cord-334133-61om170g	30	27	.	.	NNP
cord-334133-61om170g	30	28	,	,	,
cord-334133-61om170g	30	29	1991	1991	CD
cord-334133-61om170g	30	30	;	;	:
cord-334133-61om170g	30	31	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	30	32	et	et	NNP
cord-334133-61om170g	30	33	al	al	NNP
cord-334133-61om170g	30	34	.	.	NNP
cord-334133-61om170g	30	35	,	,	,
cord-334133-61om170g	30	36	1997	1997	CD
cord-334133-61om170g	30	37	;	;	:
cord-334133-61om170g	30	38	Willey	Willey	NNP
cord-334133-61om170g	30	39	et	et	NNP
cord-334133-61om170g	30	40	al	al	NNP
cord-334133-61om170g	30	41	.	.	NNP
cord-334133-61om170g	30	42	,	,	,
cord-334133-61om170g	30	43	1988	1988	CD
cord-334133-61om170g	30	44	)	)	-RRB-
cord-334133-61om170g	30	45	.	.	.
cord-334133-61om170g	31	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	31	2	gp160	gp160	NNP
cord-334133-61om170g	31	3	is	be	VBZ
cord-334133-61om170g	31	4	cleaved	cleave	VBN
cord-334133-61om170g	31	5	between	between	IN
cord-334133-61om170g	31	6	residues	residue	NNS
cord-334133-61om170g	31	7	518	518	CD
cord-334133-61om170g	31	8	R	r	NN
cord-334133-61om170g	31	9	and	and	CC
cord-334133-61om170g	31	10	519	519	CD
cord-334133-61om170g	31	11	A	a	NN
cord-334133-61om170g	31	12	by	by	IN
cord-334133-61om170g	31	13	the	the	DT
cord-334133-61om170g	31	14	subtilisin	subtilisin	NNP
cord-334133-61om170g	31	15	/	/	SYM
cord-334133-61om170g	31	16	kexin	kexin	NN
cord-334133-61om170g	31	17	-	-	HYPH
cord-334133-61om170g	31	18	like	like	JJ
cord-334133-61om170g	31	19	Ca	Ca	NNP
cord-334133-61om170g	31	20	2	2	CD
cord-334133-61om170g	32	1	+	+	CC
cord-334133-61om170g	33	1	-dependent	-dependent	JJ
cord-334133-61om170g	33	2	convertases	convertases	NNP
cord-334133-61om170g	33	3	such	such	JJ
cord-334133-61om170g	33	4	as	as	IN
cord-334133-61om170g	33	5	furin	furin	NN
cord-334133-61om170g	33	6	,	,	,
cord-334133-61om170g	33	7	PACE4	PACE4	NNP
cord-334133-61om170g	33	8	,	,	,
cord-334133-61om170g	33	9	PC5/6-B	PC5/6-B	NNP
cord-334133-61om170g	33	10	,	,	,
cord-334133-61om170g	33	11	and	and	CC
cord-334133-61om170g	33	12	PC1	PC1	NNP
cord-334133-61om170g	33	13	(	(	-LRB-
cord-334133-61om170g	33	14	Morikawa	Morikawa	NNP
cord-334133-61om170g	33	15	et	et	NNP
cord-334133-61om170g	33	16	al	al	NNP
cord-334133-61om170g	33	17	.	.	NNP
cord-334133-61om170g	33	18	,	,	,
cord-334133-61om170g	33	19	1993	1993	CD
cord-334133-61om170g	33	20	;	;	:
cord-334133-61om170g	33	21	Moulard	Moulard	NNP
cord-334133-61om170g	33	22	et	et	FW
cord-334133-61om170g	33	23	al	al	NNP
cord-334133-61om170g	33	24	.	.	.
cord-334133-61om170g	34	1	,	,	,
cord-334133-61om170g	34	2	1994	1994	CD
cord-334133-61om170g	34	3	;	;	:
cord-334133-61om170g	34	4	Vollenweider	Vollenweider	NNP
cord-334133-61om170g	34	5	et	et	NNP
cord-334133-61om170g	34	6	al	al	NNP
cord-334133-61om170g	34	7	.	.	NNP
cord-334133-61om170g	34	8	,	,	,
cord-334133-61om170g	34	9	1996	1996	CD
cord-334133-61om170g	34	10	)	)	-RRB-
cord-334133-61om170g	34	11	.	.	.
cord-334133-61om170g	35	1	Gp160	Gp160	NNP
cord-334133-61om170g	35	2	is	be	VBZ
cord-334133-61om170g	35	3	probably	probably	RB
cord-334133-61om170g	35	4	cleaved	cleave	VBN
cord-334133-61om170g	35	5	by	by	IN
cord-334133-61om170g	35	6	more	more	JJR
cord-334133-61om170g	35	7	than	than	IN
cord-334133-61om170g	35	8	one	one	CD
cord-334133-61om170g	35	9	cellular	cellular	JJ
cord-334133-61om170g	35	10	protease	protease	NN
cord-334133-61om170g	35	11	.	.	.
cord-334133-61om170g	36	1	Gp160	Gp160	NNP
cord-334133-61om170g	36	2	cleavage	cleavage	NN
cord-334133-61om170g	36	3	occurs	occur	VBZ
cord-334133-61om170g	36	4	in	in	IN
cord-334133-61om170g	36	5	the	the	DT
cord-334133-61om170g	36	6	trans	trans	NNP
cord-334133-61om170g	36	7	-	-	NNP
cord-334133-61om170g	36	8	Golgi	Golgi	NNP
cord-334133-61om170g	36	9	network	network	NN
cord-334133-61om170g	36	10	(	(	-LRB-
cord-334133-61om170g	36	11	TGN	TGN	NNP
cord-334133-61om170g	36	12	)	)	-RRB-
cord-334133-61om170g	36	13	or	or	CC
cord-334133-61om170g	36	14	after	after	IN
cord-334133-61om170g	36	15	it	-PRON-	PRP
cord-334133-61om170g	36	16	exits	exit	VBZ
cord-334133-61om170g	36	17	the	the	DT
cord-334133-61om170g	36	18	TGN	TGN	NNP
cord-334133-61om170g	36	19	(	(	-LRB-
cord-334133-61om170g	36	20	Bultmann	Bultmann	NNP
cord-334133-61om170g	36	21	et	et	NNP
cord-334133-61om170g	36	22	al	al	NNP
cord-334133-61om170g	36	23	.	.	NNP
cord-334133-61om170g	36	24	,	,	,
cord-334133-61om170g	36	25	2000	2000	CD
cord-334133-61om170g	36	26	;	;	:
cord-334133-61om170g	36	27	Pal	Pal	NNP
cord-334133-61om170g	36	28	et	et	FW
cord-334133-61om170g	36	29	al	al	NNP
cord-334133-61om170g	36	30	.	.	NNP
cord-334133-61om170g	36	31	,	,	,
cord-334133-61om170g	36	32	1991	1991	CD
cord-334133-61om170g	36	33	;	;	:
cord-334133-61om170g	36	34	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	36	35	et	et	NNP
cord-334133-61om170g	36	36	al	al	NNP
cord-334133-61om170g	36	37	.	.	NNP
cord-334133-61om170g	36	38	,	,	,
cord-334133-61om170g	36	39	1997	1997	CD
cord-334133-61om170g	36	40	;	;	:
cord-334133-61om170g	36	41	Stein	Stein	NNP
cord-334133-61om170g	36	42	and	and	CC
cord-334133-61om170g	36	43	Engelman	Engelman	NNP
cord-334133-61om170g	36	44	,	,	,
cord-334133-61om170g	36	45	1990	1990	CD
cord-334133-61om170g	36	46	)	)	-RRB-
cord-334133-61om170g	36	47	.	.	.
cord-334133-61om170g	37	1	Brefeldin	Brefeldin	NNP
cord-334133-61om170g	37	2	A	A	NNP
cord-334133-61om170g	37	3	,	,	,
cord-334133-61om170g	37	4	A1Fn	A1Fn	NNP
cord-334133-61om170g	37	5	,	,	,
cord-334133-61om170g	37	6	monensin	monensin	NNP
cord-334133-61om170g	37	7	,	,	,
cord-334133-61om170g	37	8	and	and	CC
cord-334133-61om170g	37	9	tunicamycin	tunicamycin	NNS
cord-334133-61om170g	37	10	inhibit	inhibit	VBP
cord-334133-61om170g	37	11	gp160	gp160	NNP
cord-334133-61om170g	37	12	cleavage	cleavage	NN
cord-334133-61om170g	37	13	even	even	RB
cord-334133-61om170g	37	14	when	when	WRB
cord-334133-61om170g	37	15	gp160	gp160	NNP
cord-334133-61om170g	37	16	is	be	VBZ
cord-334133-61om170g	37	17	allowed	allow	VBN
cord-334133-61om170g	37	18	to	to	TO
cord-334133-61om170g	37	19	accumulate	accumulate	VB
cord-334133-61om170g	37	20	in	in	IN
cord-334133-61om170g	37	21	the	the	DT
cord-334133-61om170g	37	22	TGN	TGN	NNP
cord-334133-61om170g	37	23	,	,	,
cord-334133-61om170g	37	24	suggesting	suggest	VBG
cord-334133-61om170g	37	25	that	that	IN
cord-334133-61om170g	37	26	cleavage	cleavage	NN
cord-334133-61om170g	37	27	occurs	occur	VBZ
cord-334133-61om170g	37	28	in	in	IN
cord-334133-61om170g	37	29	the	the	DT
cord-334133-61om170g	37	30	late	late	JJ
cord-334133-61om170g	37	31	compartment	compartment	NN
cord-334133-61om170g	37	32	of	of	IN
cord-334133-61om170g	37	33	the	the	DT
cord-334133-61om170g	37	34	Golgi	Golgi	NNP
cord-334133-61om170g	37	35	or	or	CC
cord-334133-61om170g	37	36	after	after	IN
cord-334133-61om170g	37	37	gp160	gp160	NNP
cord-334133-61om170g	37	38	has	have	VBZ
cord-334133-61om170g	37	39	exited	exit	VBN
cord-334133-61om170g	37	40	from	from	IN
cord-334133-61om170g	37	41	the	the	DT
cord-334133-61om170g	37	42	Golgi	Golgi	NNP
cord-334133-61om170g	37	43	(	(	-LRB-
cord-334133-61om170g	37	44	Dewar	Dewar	NNP
cord-334133-61om170g	37	45	et	et	FW
cord-334133-61om170g	37	46	al	al	NNP
cord-334133-61om170g	37	47	.	.	.
cord-334133-61om170g	38	1	,	,	,
cord-334133-61om170g	38	2	1989	1989	CD
cord-334133-61om170g	38	3	;	;	:
cord-334133-61om170g	38	4	Kantanen	Kantanen	NNP
cord-334133-61om170g	38	5	et	et	NNP
cord-334133-61om170g	38	6	al	al	NNP
cord-334133-61om170g	38	7	.	.	NNP
cord-334133-61om170g	38	8	,	,	,
cord-334133-61om170g	38	9	1995	1995	CD
cord-334133-61om170g	38	10	;	;	:
cord-334133-61om170g	38	11	Pal	Pal	NNP
cord-334133-61om170g	38	12	et	et	FW
cord-334133-61om170g	38	13	al	al	NNP
cord-334133-61om170g	38	14	.	.	NNP
cord-334133-61om170g	38	15	,	,	,
cord-334133-61om170g	39	1	1991	1991	CD
cord-334133-61om170g	39	2	Pal	Pal	NNP
cord-334133-61om170g	39	3	et	et	NNP
cord-334133-61om170g	39	4	al	al	NNP
cord-334133-61om170g	39	5	.	.	.
cord-334133-61om170g	40	1	,	,	,
cord-334133-61om170g	40	2	,	,	,
cord-334133-61om170g	40	3	1988	1988	CD
cord-334133-61om170g	40	4	.	.	.
cord-334133-61om170g	41	1	Cleavage	cleavage	NN
cord-334133-61om170g	41	2	may	may	MD
cord-334133-61om170g	41	3	occur	occur	VB
cord-334133-61om170g	41	4	in	in	IN
cord-334133-61om170g	41	5	an	an	DT
cord-334133-61om170g	41	6	acidic	acidic	JJ
cord-334133-61om170g	41	7	compartment	compartment	NN
cord-334133-61om170g	41	8	,	,	,
cord-334133-61om170g	41	9	as	as	IN
cord-334133-61om170g	41	10	it	-PRON-	PRP
cord-334133-61om170g	41	11	was	be	VBD
cord-334133-61om170g	41	12	inhibited	inhibit	VBN
cord-334133-61om170g	41	13	by	by	IN
cord-334133-61om170g	41	14	NH	NH	NNP
cord-334133-61om170g	41	15	4	4	CD
cord-334133-61om170g	41	16	Cl	Cl	NNP
cord-334133-61om170g	41	17	and	and	CC
cord-334133-61om170g	41	18	partially	partially	RB
cord-334133-61om170g	41	19	inhibited	inhibit	VBN
cord-334133-61om170g	41	20	by	by	IN
cord-334133-61om170g	41	21	chloroquine	chloroquine	NN
cord-334133-61om170g	41	22	(	(	-LRB-
cord-334133-61om170g	41	23	Courageot	Courageot	NNP
cord-334133-61om170g	41	24	et	et	NNP
cord-334133-61om170g	41	25	al	al	NNP
cord-334133-61om170g	41	26	.	.	NNP
cord-334133-61om170g	41	27	,	,	,
cord-334133-61om170g	41	28	1999	1999	CD
cord-334133-61om170g	41	29	;	;	:
cord-334133-61om170g	41	30	Willey	Willey	NNP
cord-334133-61om170g	41	31	et	et	NNP
cord-334133-61om170g	41	32	al	al	NNP
cord-334133-61om170g	41	33	.	.	NNP
cord-334133-61om170g	41	34	,	,	,
cord-334133-61om170g	41	35	1988	1988	CD
cord-334133-61om170g	41	36	)	)	-RRB-
cord-334133-61om170g	41	37	.	.	.
cord-334133-61om170g	42	1	However	however	RB
cord-334133-61om170g	42	2	,	,	,
cord-334133-61om170g	42	3	these	these	DT
cord-334133-61om170g	42	4	inhibitors	inhibitor	NNS
cord-334133-61om170g	42	5	may	may	MD
cord-334133-61om170g	42	6	prevent	prevent	VB
cord-334133-61om170g	42	7	gp160	gp160	NNP
cord-334133-61om170g	42	8	from	from	IN
cord-334133-61om170g	42	9	reaching	reach	VBG
cord-334133-61om170g	42	10	the	the	DT
cord-334133-61om170g	42	11	correct	correct	JJ
cord-334133-61om170g	42	12	intracellular	intracellular	JJ
cord-334133-61om170g	42	13	site	site	NN
cord-334133-61om170g	42	14	for	for	IN
cord-334133-61om170g	42	15	cleavage	cleavage	NN
cord-334133-61om170g	42	16	.	.	.
cord-334133-61om170g	43	1	Methionine	methionine	NN
cord-334133-61om170g	43	2	methyl	methyl	NN
cord-334133-61om170g	43	3	ester	ester	NN
cord-334133-61om170g	43	4	failed	fail	VBD
cord-334133-61om170g	43	5	to	to	TO
cord-334133-61om170g	43	6	inhibit	inhibit	VB
cord-334133-61om170g	43	7	gp160	gp160	NNP
cord-334133-61om170g	43	8	cleavage	cleavage	NN
cord-334133-61om170g	43	9	,	,	,
cord-334133-61om170g	43	10	indicating	indicate	VBG
cord-334133-61om170g	43	11	that	that	IN
cord-334133-61om170g	43	12	cleavage	cleavage	NN
cord-334133-61om170g	43	13	may	may	MD
cord-334133-61om170g	43	14	occur	occur	VB
cord-334133-61om170g	43	15	in	in	IN
cord-334133-61om170g	43	16	a	a	DT
cord-334133-61om170g	43	17	non	non	JJ
cord-334133-61om170g	43	18	-	-	JJ
cord-334133-61om170g	43	19	lysosomal	lysosomal	JJ
cord-334133-61om170g	43	20	compartment	compartment	NN
cord-334133-61om170g	43	21	(	(	-LRB-
cord-334133-61om170g	43	22	Willey	Willey	NNP
cord-334133-61om170g	43	23	et	et	NNP
cord-334133-61om170g	43	24	al	al	NNP
cord-334133-61om170g	43	25	.	.	NNP
cord-334133-61om170g	43	26	,	,	,
cord-334133-61om170g	43	27	1988	1988	CD
cord-334133-61om170g	43	28	)	)	-RRB-
cord-334133-61om170g	43	29	.	.	.
cord-334133-61om170g	44	1	Only	only	RB
cord-334133-61om170g	44	2	a	a	DT
cord-334133-61om170g	44	3	small	small	JJ
cord-334133-61om170g	44	4	proportion	proportion	NN
cord-334133-61om170g	44	5	of	of	IN
cord-334133-61om170g	44	6	gp160	gp160	NNP
cord-334133-61om170g	44	7	(	(	-LRB-
cord-334133-61om170g	44	8	5	5	CD
cord-334133-61om170g	44	9	-	-	SYM
cord-334133-61om170g	44	10	40	40	CD
cord-334133-61om170g	44	11	%	%	NN
cord-334133-61om170g	44	12	)	)	-RRB-
cord-334133-61om170g	44	13	is	be	VBZ
cord-334133-61om170g	44	14	cleaved	cleave	VBN
cord-334133-61om170g	44	15	into	into	IN
cord-334133-61om170g	44	16	gp120-gp41	gp120-gp41	NNP
cord-334133-61om170g	44	17	,	,	,
cord-334133-61om170g	44	18	and	and	CC
cord-334133-61om170g	44	19	this	this	DT
cord-334133-61om170g	44	20	depends	depend	VBZ
cord-334133-61om170g	44	21	on	on	IN
cord-334133-61om170g	44	22	the	the	DT
cord-334133-61om170g	44	23	host	host	NN
cord-334133-61om170g	44	24	cell	cell	NN
cord-334133-61om170g	44	25	(	(	-LRB-
cord-334133-61om170g	44	26	Bird	Bird	NNP
cord-334133-61om170g	44	27	et	et	NNP
cord-334133-61om170g	44	28	al	al	NNP
cord-334133-61om170g	44	29	.	.	NNP
cord-334133-61om170g	44	30	,	,	,
cord-334133-61om170g	44	31	1990	1990	CD
cord-334133-61om170g	44	32	;	;	:
cord-334133-61om170g	44	33	Hallenberger	Hallenberger	NNP
cord-334133-61om170g	44	34	et	et	NNP
cord-334133-61om170g	44	35	al	al	NNP
cord-334133-61om170g	44	36	.	.	NNP
cord-334133-61om170g	44	37	,	,	,
cord-334133-61om170g	44	38	1993	1993	CD
cord-334133-61om170g	44	39	;	;	:
cord-334133-61om170g	45	1	Jose	Jose	NNP
cord-334133-61om170g	45	2	et	et	NNP
cord-334133-61om170g	45	3	al	al	NNP
cord-334133-61om170g	45	4	.	.	NNP
cord-334133-61om170g	45	5	,	,	,
cord-334133-61om170g	45	6	1997	1997	CD
cord-334133-61om170g	45	7	;	;	:
cord-334133-61om170g	45	8	Kimura	Kimura	NNP
cord-334133-61om170g	45	9	et	et	NNP
cord-334133-61om170g	45	10	al	al	NNP
cord-334133-61om170g	45	11	.	.	NNP
cord-334133-61om170g	45	12	,	,	,
cord-334133-61om170g	45	13	1996	1996	CD
cord-334133-61om170g	46	1	;	;	:
cord-334133-61om170g	46	2	Kozarsky	Kozarsky	NNP
cord-334133-61om170g	46	3	et	et	NNP
cord-334133-61om170g	46	4	al	al	NNP
cord-334133-61om170g	46	5	.	.	.
cord-334133-61om170g	47	1	,	,	,
cord-334133-61om170g	47	2	1989	1989	CD
cord-334133-61om170g	47	3	;	;	:
cord-334133-61om170g	47	4	Moulard	Moulard	NNP
cord-334133-61om170g	47	5	et	et	FW
cord-334133-61om170g	47	6	al	al	NNP
cord-334133-61om170g	47	7	.	.	.
cord-334133-61om170g	48	1	,	,	,
cord-334133-61om170g	48	2	1999	1999	CD
cord-334133-61om170g	48	3	;	;	:
cord-334133-61om170g	48	4	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	48	5	et	et	NNP
cord-334133-61om170g	48	6	al	al	NNP
cord-334133-61om170g	48	7	.	.	NNP
cord-334133-61om170g	48	8	,	,	,
cord-334133-61om170g	48	9	1997	1997	CD
cord-334133-61om170g	48	10	;	;	:
cord-334133-61om170g	48	11	Willey	Willey	NNP
cord-334133-61om170g	48	12	et	et	NNP
cord-334133-61om170g	48	13	al	al	NNP
cord-334133-61om170g	48	14	.	.	NNP
cord-334133-61om170g	48	15	,	,	,
cord-334133-61om170g	48	16	1988	1988	CD
cord-334133-61om170g	49	1	Willey	Willey	NNP
cord-334133-61om170g	49	2	et	et	NNP
cord-334133-61om170g	49	3	al	al	NNP
cord-334133-61om170g	49	4	.	.	NNP
cord-334133-61om170g	49	5	,	,	,
cord-334133-61om170g	49	6	,	,	,
cord-334133-61om170g	49	7	1991	1991	CD
cord-334133-61om170g	49	8	.	.	.
cord-334133-61om170g	50	1	For	for	IN
cord-334133-61om170g	50	2	example	example	NN
cord-334133-61om170g	50	3	,	,	,
cord-334133-61om170g	50	4	10	10	CD
cord-334133-61om170g	50	5	-20	-20	CD
cord-334133-61om170g	50	6	%	%	NN
cord-334133-61om170g	50	7	of	of	IN
cord-334133-61om170g	50	8	gp160	gp160	NNP
cord-334133-61om170g	50	9	is	be	VBZ
cord-334133-61om170g	50	10	cleaved	cleave	VBN
cord-334133-61om170g	50	11	in	in	IN
cord-334133-61om170g	50	12	peripheral	peripheral	JJ
cord-334133-61om170g	50	13	blood	blood	NN
cord-334133-61om170g	50	14	lymphocytes	lymphocyte	NNS
cord-334133-61om170g	50	15	(	(	-LRB-
cord-334133-61om170g	50	16	Willey	Willey	NNP
cord-334133-61om170g	50	17	et	et	NNP
cord-334133-61om170g	50	18	al	al	NNP
cord-334133-61om170g	50	19	.	.	NNP
cord-334133-61om170g	50	20	,	,	,
cord-334133-61om170g	50	21	1988	1988	CD
cord-334133-61om170g	50	22	)	)	-RRB-
cord-334133-61om170g	50	23	.	.	.
cord-334133-61om170g	51	1	Uncleaved	uncleaved	JJ
cord-334133-61om170g	51	2	,	,	,
cord-334133-61om170g	51	3	trimeric	trimeric	NNP
cord-334133-61om170g	51	4	gp160	gp160	NNP
cord-334133-61om170g	51	5	is	be	VBZ
cord-334133-61om170g	51	6	degraded	degrade	VBN
cord-334133-61om170g	51	7	in	in	IN
cord-334133-61om170g	51	8	the	the	DT
cord-334133-61om170g	51	9	ER	er	NN
cord-334133-61om170g	51	10	and	and	CC
cord-334133-61om170g	51	11	lysosomes	lysosome	NNS
cord-334133-61om170g	51	12	.	.	.
cord-334133-61om170g	52	1	However	however	RB
cord-334133-61om170g	52	2	,	,	,
cord-334133-61om170g	52	3	the	the	DT
cord-334133-61om170g	52	4	proportion	proportion	NN
cord-334133-61om170g	52	5	degraded	degrade	VBN
cord-334133-61om170g	52	6	in	in	IN
cord-334133-61om170g	52	7	each	each	DT
cord-334133-61om170g	52	8	location	location	NN
cord-334133-61om170g	52	9	is	be	VBZ
cord-334133-61om170g	52	10	not	not	RB
cord-334133-61om170g	52	11	known	know	VBN
cord-334133-61om170g	52	12	.	.	.
cord-334133-61om170g	53	1	According	accord	VBG
cord-334133-61om170g	53	2	to	to	IN
cord-334133-61om170g	53	3	Willey	Willey	NNP
cord-334133-61om170g	53	4	et	et	NNP
cord-334133-61om170g	53	5	al	al	NNP
cord-334133-61om170g	53	6	.	.	NNP
cord-334133-61om170g	53	7	,	,	,
cord-334133-61om170g	53	8	most	most	JJS
cord-334133-61om170g	53	9	gp160	gp160	NNP
cord-334133-61om170g	53	10	leaves	leave	VBZ
cord-334133-61om170g	53	11	the	the	DT
cord-334133-61om170g	53	12	ER	er	NN
cord-334133-61om170g	53	13	and	and	CC
cord-334133-61om170g	53	14	reaches	reach	VBZ
cord-334133-61om170g	53	15	the	the	DT
cord-334133-61om170g	53	16	Golgi	Golgi	NNP
cord-334133-61om170g	53	17	,	,	,
cord-334133-61om170g	53	18	and	and	CC
cord-334133-61om170g	53	19	the	the	DT
cord-334133-61om170g	53	20	minority	minority	NN
cord-334133-61om170g	53	21	that	that	WDT
cord-334133-61om170g	53	22	remains	remain	VBZ
cord-334133-61om170g	53	23	in	in	IN
cord-334133-61om170g	53	24	the	the	DT
cord-334133-61om170g	53	25	ER	ER	NNP
cord-334133-61om170g	53	26	is	be	VBZ
cord-334133-61om170g	53	27	degraded	degrade	VBN
cord-334133-61om170g	53	28	there	there	RB
cord-334133-61om170g	54	1	(	(	-LRB-
cord-334133-61om170g	54	2	Willey	Willey	NNP
cord-334133-61om170g	54	3	et	et	NNP
cord-334133-61om170g	54	4	al	al	NNP
cord-334133-61om170g	54	5	.	.	NNP
cord-334133-61om170g	54	6	,	,	,
cord-334133-61om170g	54	7	1988	1988	CD
cord-334133-61om170g	54	8	)	)	-RRB-
cord-334133-61om170g	54	9	.	.	.
cord-334133-61om170g	55	1	However	however	RB
cord-334133-61om170g	55	2	,	,	,
cord-334133-61om170g	55	3	others	other	NNS
cord-334133-61om170g	55	4	find	find	VBP
cord-334133-61om170g	55	5	that	that	IN
cord-334133-61om170g	55	6	most	most	JJS
cord-334133-61om170g	55	7	gp160	gp160	NNP
cord-334133-61om170g	55	8	remains	remain	VBZ
cord-334133-61om170g	55	9	in	in	IN
cord-334133-61om170g	55	10	the	the	DT
cord-334133-61om170g	55	11	ER	er	NN
cord-334133-61om170g	55	12	and	and	CC
cord-334133-61om170g	55	13	is	be	VBZ
cord-334133-61om170g	55	14	degraded	degrade	VBN
cord-334133-61om170g	55	15	(	(	-LRB-
cord-334133-61om170g	56	1	Bultmann	Bultmann	NNP
cord-334133-61om170g	56	2	et	et	NNP
cord-334133-61om170g	56	3	al	al	NNP
cord-334133-61om170g	56	4	.	.	NNP
cord-334133-61om170g	56	5	,	,	,
cord-334133-61om170g	56	6	2000	2000	CD
cord-334133-61om170g	57	1	;	;	:
cord-334133-61om170g	57	2	Courageot	Courageot	NNP
cord-334133-61om170g	57	3	et	et	NNP
cord-334133-61om170g	57	4	al	al	NNP
cord-334133-61om170g	57	5	.	.	NNP
cord-334133-61om170g	57	6	,	,	,
cord-334133-61om170g	57	7	1999	1999	CD
cord-334133-61om170g	57	8	;	;	:
cord-334133-61om170g	57	9	Hallenberger	Hallenberger	NNP
cord-334133-61om170g	57	10	et	et	NNP
cord-334133-61om170g	57	11	al	al	NNP
cord-334133-61om170g	57	12	.	.	.
cord-334133-61om170g	58	1	,	,	,
cord-334133-61om170g	58	2	1993	1993	CD
cord-334133-61om170g	58	3	;	;	:
cord-334133-61om170g	58	4	Jabbar	Jabbar	NNP
cord-334133-61om170g	58	5	and	and	CC
cord-334133-61om170g	58	6	Nayak	Nayak	NNP
cord-334133-61om170g	58	7	,	,	,
cord-334133-61om170g	58	8	1990	1990	CD
cord-334133-61om170g	58	9	;	;	:
cord-334133-61om170g	58	10	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	58	11	et	et	NNP
cord-334133-61om170g	58	12	al	al	NNP
cord-334133-61om170g	58	13	.	.	NNP
cord-334133-61om170g	58	14	,	,	,
cord-334133-61om170g	58	15	1997	1997	CD
cord-334133-61om170g	58	16	)	)	-RRB-
cord-334133-61om170g	58	17	,	,	,
cord-334133-61om170g	58	18	or	or	CC
cord-334133-61om170g	58	19	is	be	VBZ
cord-334133-61om170g	58	20	rapidly	rapidly	RB
cord-334133-61om170g	58	21	sent	send	VBN
cord-334133-61om170g	58	22	to	to	IN
cord-334133-61om170g	58	23	lysosomes	lysosome	NNS
cord-334133-61om170g	58	24	and	and	CC
cord-334133-61om170g	58	25	degraded	degrade	VBN
cord-334133-61om170g	58	26	(	(	-LRB-
cord-334133-61om170g	58	27	Jabbar	Jabbar	NNP
cord-334133-61om170g	58	28	and	and	CC
cord-334133-61om170g	58	29	Nayak	Nayak	NNP
cord-334133-61om170g	58	30	,	,	,
cord-334133-61om170g	58	31	1990	1990	CD
cord-334133-61om170g	58	32	;	;	:
cord-334133-61om170g	58	33	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	58	34	et	et	NNP
cord-334133-61om170g	58	35	al	al	NNP
cord-334133-61om170g	58	36	.	.	NNP
cord-334133-61om170g	58	37	,	,	,
cord-334133-61om170g	58	38	1997	1997	CD
cord-334133-61om170g	58	39	)	)	-RRB-
cord-334133-61om170g	58	40	.	.	.
cord-334133-61om170g	59	1	Whichever	whichever	WDT
cord-334133-61om170g	59	2	the	the	DT
cord-334133-61om170g	59	3	location	location	NN
cord-334133-61om170g	59	4	,	,	,
cord-334133-61om170g	59	5	degradation	degradation	NN
cord-334133-61om170g	59	6	is	be	VBZ
cord-334133-61om170g	59	7	relatively	relatively	RB
cord-334133-61om170g	59	8	rapid	rapid	JJ
cord-334133-61om170g	59	9	,	,	,
cord-334133-61om170g	59	10	and	and	CC
cord-334133-61om170g	59	11	only	only	RB
cord-334133-61om170g	59	12	10	10	CD
cord-334133-61om170g	59	13	-20	-20	CD
cord-334133-61om170g	59	14	%	%	NN
cord-334133-61om170g	59	15	of	of	IN
cord-334133-61om170g	59	16	gp160	gp160	NNP
cord-334133-61om170g	59	17	remains	remain	VBZ
cord-334133-61om170g	59	18	after	after	IN
cord-334133-61om170g	59	19	8	8	CD
cord-334133-61om170g	59	20	h	h	NN
cord-334133-61om170g	59	21	(	(	-LRB-
cord-334133-61om170g	59	22	Willey	Willey	NNP
cord-334133-61om170g	59	23	et	et	NNP
cord-334133-61om170g	59	24	al	al	NNP
cord-334133-61om170g	59	25	.	.	NNP
cord-334133-61om170g	59	26	,	,	,
cord-334133-61om170g	59	27	1988	1988	CD
cord-334133-61om170g	59	28	)	)	-RRB-
cord-334133-61om170g	59	29	.	.	.
cord-334133-61om170g	60	1	When	when	WRB
cord-334133-61om170g	60	2	prevented	prevent	VBN
cord-334133-61om170g	60	3	from	from	IN
cord-334133-61om170g	60	4	leaving	leave	VBG
cord-334133-61om170g	60	5	the	the	DT
cord-334133-61om170g	60	6	ER	ER	NNP
cord-334133-61om170g	60	7	,	,	,
cord-334133-61om170g	60	8	gp160	gp160	NNP
cord-334133-61om170g	60	9	accumulates	accumulate	VBZ
cord-334133-61om170g	60	10	there	there	RB
cord-334133-61om170g	60	11	and	and	CC
cord-334133-61om170g	60	12	is	be	VBZ
cord-334133-61om170g	60	13	degraded	degrade	VBN
cord-334133-61om170g	60	14	(	(	-LRB-
cord-334133-61om170g	61	1	Courageot	Courageot	NNP
cord-334133-61om170g	61	2	et	et	NNP
cord-334133-61om170g	61	3	al	al	NNP
cord-334133-61om170g	61	4	.	.	.
cord-334133-61om170g	62	1	,	,	,
cord-334133-61om170g	62	2	1999	1999	CD
cord-334133-61om170g	62	3	;	;	:
cord-334133-61om170g	62	4	Pal	Pal	NNP
cord-334133-61om170g	62	5	et	et	FW
cord-334133-61om170g	62	6	al	al	NNP
cord-334133-61om170g	62	7	.	.	NNP
cord-334133-61om170g	62	8	,	,	,
cord-334133-61om170g	62	9	1991	1991	CD
cord-334133-61om170g	62	10	;	;	:
cord-334133-61om170g	62	11	Willey	Willey	NNP
cord-334133-61om170g	62	12	et	et	NNP
cord-334133-61om170g	62	13	al	al	NNP
cord-334133-61om170g	62	14	.	.	NNP
cord-334133-61om170g	62	15	,	,	,
cord-334133-61om170g	62	16	1991	1991	CD
cord-334133-61om170g	62	17	)	)	-RRB-
cord-334133-61om170g	62	18	.	.	.
cord-334133-61om170g	63	1	Gp160	Gp160	NNP
cord-334133-61om170g	63	2	degradation	degradation	NN
cord-334133-61om170g	63	3	has	have	VBZ
cord-334133-61om170g	63	4	also	also	RB
cord-334133-61om170g	63	5	been	be	VBN
cord-334133-61om170g	63	6	observed	observe	VBN
cord-334133-61om170g	63	7	in	in	IN
cord-334133-61om170g	63	8	proteosomes	proteosome	NNS
cord-334133-61om170g	63	9	(	(	-LRB-
cord-334133-61om170g	63	10	Bultmann	Bultmann	NNP
cord-334133-61om170g	63	11	et	et	NNP
cord-334133-61om170g	63	12	al	al	NNP
cord-334133-61om170g	63	13	.	.	NNP
cord-334133-61om170g	63	14	,	,	,
cord-334133-61om170g	63	15	2000	2000	CD
cord-334133-61om170g	63	16	)	)	-RRB-
cord-334133-61om170g	63	17	.	.	.
cord-334133-61om170g	64	1	The	the	DT
cord-334133-61om170g	64	2	consensus	consensus	NN
cord-334133-61om170g	64	3	view	view	NN
cord-334133-61om170g	64	4	is	be	VBZ
cord-334133-61om170g	64	5	that	that	IN
cord-334133-61om170g	64	6	most	most	JJS
cord-334133-61om170g	64	7	gp160	gp160	NNP
cord-334133-61om170g	64	8	is	be	VBZ
cord-334133-61om170g	64	9	degraded	degrade	VBN
cord-334133-61om170g	64	10	in	in	IN
cord-334133-61om170g	64	11	the	the	DT
cord-334133-61om170g	64	12	ER	er	NN
cord-334133-61om170g	64	13	,	,	,
cord-334133-61om170g	64	14	and	and	CC
cord-334133-61om170g	64	15	only	only	RB
cord-334133-61om170g	64	16	a	a	DT
cord-334133-61om170g	64	17	minority	minority	NN
cord-334133-61om170g	64	18	reaches	reach	VBZ
cord-334133-61om170g	64	19	the	the	DT
cord-334133-61om170g	64	20	Golgi	Golgi	NNP
cord-334133-61om170g	64	21	.	.	.
cord-334133-61om170g	65	1	Of	of	IN
cord-334133-61om170g	65	2	the	the	DT
cord-334133-61om170g	65	3	latter	latter	JJ
cord-334133-61om170g	65	4	,	,	,
cord-334133-61om170g	65	5	most	most	JJS
cord-334133-61om170g	65	6	(	(	-LRB-
cord-334133-61om170g	65	7	85	85	CD
cord-334133-61om170g	65	8	-95	-95	NN
cord-334133-61om170g	65	9	%	%	NN
cord-334133-61om170g	65	10	)	)	-RRB-
cord-334133-61om170g	65	11	is	be	VBZ
cord-334133-61om170g	65	12	degraded	degrade	VBN
cord-334133-61om170g	65	13	in	in	IN
cord-334133-61om170g	65	14	lysosomes	lysosome	NNS
cord-334133-61om170g	65	15	,	,	,
cord-334133-61om170g	65	16	and	and	CC
cord-334133-61om170g	65	17	the	the	DT
cord-334133-61om170g	65	18	remainder	remainder	NN
cord-334133-61om170g	65	19	is	be	VBZ
cord-334133-61om170g	65	20	targeted	target	VBN
cord-334133-61om170g	65	21	as	as	IN
cord-334133-61om170g	65	22	gp120-gp41	gp120-gp41	NNP
cord-334133-61om170g	65	23	to	to	IN
cord-334133-61om170g	65	24	the	the	DT
cord-334133-61om170g	65	25	cell	cell	NN
cord-334133-61om170g	65	26	surface	surface	NN
cord-334133-61om170g	65	27	(	(	-LRB-
cord-334133-61om170g	65	28	Willey	Willey	NNP
cord-334133-61om170g	65	29	et	et	NNP
cord-334133-61om170g	65	30	al	al	NNP
cord-334133-61om170g	65	31	.	.	NNP
cord-334133-61om170g	65	32	,	,	,
cord-334133-61om170g	65	33	1988	1988	CD
cord-334133-61om170g	65	34	)	)	-RRB-
cord-334133-61om170g	65	35	.	.	.
cord-334133-61om170g	66	1	Gp120	Gp120	NNP
cord-334133-61om170g	66	2	is	be	VBZ
cord-334133-61om170g	66	3	relatively	relatively	RB
cord-334133-61om170g	66	4	stable	stable	JJ
cord-334133-61om170g	66	5	,	,	,
cord-334133-61om170g	66	6	and	and	CC
cord-334133-61om170g	66	7	30	30	CD
cord-334133-61om170g	66	8	-50	-50	NN
cord-334133-61om170g	66	9	%	%	NN
cord-334133-61om170g	66	10	can	can	MD
cord-334133-61om170g	66	11	be	be	VB
cord-334133-61om170g	66	12	detected	detect	VBN
cord-334133-61om170g	66	13	as	as	IN
cord-334133-61om170g	66	14	secreted	secrete	VBN
cord-334133-61om170g	66	15	or	or	CC
cord-334133-61om170g	66	16	intracellular	intracellular	JJ
cord-334133-61om170g	66	17	protein	protein	NN
cord-334133-61om170g	66	18	24	24	CD
cord-334133-61om170g	66	19	h	h	NN
cord-334133-61om170g	66	20	later	later	RB
cord-334133-61om170g	67	1	(	(	-LRB-
cord-334133-61om170g	67	2	Bird	Bird	NNP
cord-334133-61om170g	67	3	et	et	NNP
cord-334133-61om170g	67	4	al	al	NNP
cord-334133-61om170g	67	5	.	.	NNP
cord-334133-61om170g	67	6	,	,	,
cord-334133-61om170g	67	7	1990	1990	CD
cord-334133-61om170g	67	8	;	;	:
cord-334133-61om170g	67	9	Willey	Willey	NNP
cord-334133-61om170g	67	10	et	et	NNP
cord-334133-61om170g	67	11	al	al	NNP
cord-334133-61om170g	67	12	.	.	NNP
cord-334133-61om170g	67	13	,	,	,
cord-334133-61om170g	67	14	1988	1988	CD
cord-334133-61om170g	67	15	Willey	Willey	NNP
cord-334133-61om170g	67	16	et	et	NNP
cord-334133-61om170g	67	17	al	al	NNP
cord-334133-61om170g	67	18	.	.	NNP
cord-334133-61om170g	67	19	,	,	,
cord-334133-61om170g	67	20	,	,	,
cord-334133-61om170g	67	21	1991	1991	CD
cord-334133-61om170g	67	22	.	.	.
cord-334133-61om170g	68	1	The	the	DT
cord-334133-61om170g	68	2	amount	amount	NN
cord-334133-61om170g	68	3	of	of	IN
cord-334133-61om170g	68	4	gp160	gp160	NNP
cord-334133-61om170g	68	5	secreted	secrete	VBN
cord-334133-61om170g	68	6	from	from	IN
cord-334133-61om170g	68	7	the	the	DT
cord-334133-61om170g	68	8	cell	cell	NN
cord-334133-61om170g	68	9	is	be	VBZ
cord-334133-61om170g	68	10	less	less	JJR
cord-334133-61om170g	68	11	than	than	IN
cord-334133-61om170g	68	12	10	10	CD
cord-334133-61om170g	68	13	%	%	NN
cord-334133-61om170g	68	14	of	of	IN
cord-334133-61om170g	68	15	the	the	DT
cord-334133-61om170g	68	16	gp120	gp120	NNP
cord-334133-61om170g	68	17	secreted	secrete	VBN
cord-334133-61om170g	68	18	(	(	-LRB-
cord-334133-61om170g	68	19	Willey	Willey	NNP
cord-334133-61om170g	68	20	et	et	NNP
cord-334133-61om170g	68	21	al	al	NNP
cord-334133-61om170g	68	22	.	.	NNP
cord-334133-61om170g	68	23	,	,	,
cord-334133-61om170g	68	24	1988	1988	CD
cord-334133-61om170g	68	25	)	)	-RRB-
cord-334133-61om170g	68	26	,	,	,
cord-334133-61om170g	68	27	although	although	IN
cord-334133-61om170g	68	28	the	the	DT
cord-334133-61om170g	68	29	amount	amount	NN
cord-334133-61om170g	68	30	varies	vary	VBZ
cord-334133-61om170g	68	31	with	with	IN
cord-334133-61om170g	68	32	the	the	DT
cord-334133-61om170g	68	33	type	type	NN
cord-334133-61om170g	68	34	of	of	IN
cord-334133-61om170g	68	35	host	host	NN
cord-334133-61om170g	68	36	cell	cell	NN
cord-334133-61om170g	69	1	(	(	-LRB-
cord-334133-61om170g	69	2	Moulard	Moulard	NNP
cord-334133-61om170g	69	3	et	et	FW
cord-334133-61om170g	69	4	al	al	NNP
cord-334133-61om170g	69	5	.	.	NNP
cord-334133-61om170g	69	6	,	,	,
cord-334133-61om170g	69	7	1999	1999	CD
cord-334133-61om170g	69	8	)	)	-RRB-
cord-334133-61om170g	69	9	.	.	.
cord-334133-61om170g	70	1	Tyrosine	tyrosine	NN
cord-334133-61om170g	70	2	-	-	HYPH
cord-334133-61om170g	70	3	dependent	dependent	JJ
cord-334133-61om170g	70	4	sorting	sorting	NN
cord-334133-61om170g	70	5	signals	signal	NNS
cord-334133-61om170g	70	6	(	(	-LRB-
cord-334133-61om170g	70	7	YxxB	YxxB	NNP
cord-334133-61om170g	70	8	,	,	,
cord-334133-61om170g	70	9	where	where	WRB
cord-334133-61om170g	70	10	x	x	NN
cord-334133-61om170g	70	11	represents	represent	VBZ
cord-334133-61om170g	70	12	any	any	DT
cord-334133-61om170g	70	13	amino	amino	NN
cord-334133-61om170g	70	14	acid	acid	NN
cord-334133-61om170g	70	15	residue	residue	NN
cord-334133-61om170g	70	16	and	and	CC
cord-334133-61om170g	70	17	B	B	NNP
cord-334133-61om170g	70	18	represents	represent	VBZ
cord-334133-61om170g	70	19	a	a	DT
cord-334133-61om170g	70	20	bulky	bulky	JJ
cord-334133-61om170g	70	21	hydrophobic	hydrophobic	JJ
cord-334133-61om170g	70	22	residue	residue	NN
cord-334133-61om170g	70	23	)	)	-RRB-
cord-334133-61om170g	70	24	,	,	,
cord-334133-61om170g	70	25	and	and	CC
cord-334133-61om170g	70	26	possibly	possibly	RB
cord-334133-61om170g	70	27	di	di	NN
cord-334133-61om170g	70	28	-	-	HYPH
cord-334133-61om170g	70	29	leucine	leucine	NN
cord-334133-61om170g	70	30	-	-	HYPH
cord-334133-61om170g	70	31	sorting	sorting	NN
cord-334133-61om170g	70	32	signals	signal	NNS
cord-334133-61om170g	70	33	are	be	VBP
cord-334133-61om170g	70	34	found	find	VBN
cord-334133-61om170g	70	35	in	in	IN
cord-334133-61om170g	70	36	the	the	DT
cord-334133-61om170g	70	37	C	c	NN
cord-334133-61om170g	70	38	-	-	HYPH
cord-334133-61om170g	70	39	terminal	terminal	NN
cord-334133-61om170g	70	40	tail	tail	NN
cord-334133-61om170g	70	41	of	of	IN
cord-334133-61om170g	70	42	gp41	gp41	NN
cord-334133-61om170g	70	43	,	,	,
cord-334133-61om170g	70	44	and	and	CC
cord-334133-61om170g	70	45	have	have	VBP
cord-334133-61om170g	70	46	been	be	VBN
cord-334133-61om170g	70	47	implicated	implicate	VBN
cord-334133-61om170g	70	48	in	in	IN
cord-334133-61om170g	70	49	transport	transport	NN
cord-334133-61om170g	70	50	of	of	IN
cord-334133-61om170g	70	51	gp160	gp160	NNP
cord-334133-61om170g	70	52	and	and	CC
cord-334133-61om170g	70	53	gp120-gp41	gp120-gp41	NNP
cord-334133-61om170g	71	1	(	(	-LRB-
cord-334133-61om170g	71	2	see	see	VB
cord-334133-61om170g	71	3	Results	result	NNS
cord-334133-61om170g	71	4	and	and	CC
cord-334133-61om170g	71	5	discussion	discussion	NN
cord-334133-61om170g	71	6	section	section	NN
cord-334133-61om170g	71	7	and	and	CC
cord-334133-61om170g	71	8	Berlioz	Berlioz	NNP
cord-334133-61om170g	71	9	-	-	HYPH
cord-334133-61om170g	71	10	Torrent	Torrent	NNP
cord-334133-61om170g	71	11	et	et	FW
cord-334133-61om170g	71	12	al	al	NNP
cord-334133-61om170g	71	13	.	.	NNP
cord-334133-61om170g	71	14	,	,	,
cord-334133-61om170g	71	15	1999	1999	CD
cord-334133-61om170g	71	16	;	;	:
cord-334133-61om170g	72	1	Boge	Boge	NNP
cord-334133-61om170g	72	2	et	et	NNP
cord-334133-61om170g	72	3	al	al	NNP
cord-334133-61om170g	72	4	.	.	NNP
cord-334133-61om170g	72	5	,	,	,
cord-334133-61om170g	72	6	1998	1998	CD
cord-334133-61om170g	72	7	;	;	:
cord-334133-61om170g	72	8	Bu	Bu	NNP
cord-334133-61om170g	72	9	et	et	NNP
cord-334133-61om170g	72	10	al	al	NNP
cord-334133-61om170g	72	11	.	.	NNP
cord-334133-61om170g	72	12	,	,	,
cord-334133-61om170g	72	13	2004	2004	CD
cord-334133-61om170g	73	1	;	;	:
cord-334133-61om170g	73	2	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	73	3	et	et	FW
cord-334133-61om170g	73	4	al	al	NNP
cord-334133-61om170g	73	5	.	.	NNP
cord-334133-61om170g	73	6	,	,	,
cord-334133-61om170g	73	7	1999	1999	CD
cord-334133-61om170g	73	8	;	;	:
cord-334133-61om170g	73	9	Egan	Egan	NNP
cord-334133-61om170g	73	10	et	et	NNP
cord-334133-61om170g	73	11	al	al	NNP
cord-334133-61om170g	73	12	.	.	.
cord-334133-61om170g	74	1	,	,	,
cord-334133-61om170g	74	2	1996	1996	CD
cord-334133-61om170g	74	3	;	;	:
cord-334133-61om170g	74	4	Lodge	Lodge	NNP
cord-334133-61om170g	74	5	et	et	NNP
cord-334133-61om170g	74	6	al	al	NNP
cord-334133-61om170g	74	7	.	.	NNP
cord-334133-61om170g	74	8	,	,	,
cord-334133-61om170g	74	9	1997	1997	CD
cord-334133-61om170g	74	10	;	;	:
cord-334133-61om170g	74	11	Ohno	Ohno	NNP
cord-334133-61om170g	74	12	et	et	NNP
cord-334133-61om170g	74	13	al	al	NNP
cord-334133-61om170g	74	14	.	.	NNP
cord-334133-61om170g	74	15	,	,	,
cord-334133-61om170g	74	16	1997	1997	CD
cord-334133-61om170g	74	17	;	;	:
cord-334133-61om170g	74	18	Owens	Owens	NNP
cord-334133-61om170g	74	19	et	et	NNP
cord-334133-61om170g	74	20	al	al	NNP
cord-334133-61om170g	74	21	.	.	NNP
cord-334133-61om170g	74	22	,	,	,
cord-334133-61om170g	74	23	1991	1991	CD
cord-334133-61om170g	74	24	;	;	:
cord-334133-61om170g	75	1	Rowell	Rowell	NNP
cord-334133-61om170g	75	2	et	et	NNP
cord-334133-61om170g	75	3	al	al	NNP
cord-334133-61om170g	75	4	.	.	.
cord-334133-61om170g	76	1	,	,	,
cord-334133-61om170g	76	2	1995	1995	CD
cord-334133-61om170g	76	3	;	;	:
cord-334133-61om170g	76	4	West	West	NNP
cord-334133-61om170g	76	5	et	et	NNP
cord-334133-61om170g	76	6	al	al	NNP
cord-334133-61om170g	76	7	.	.	.
cord-334133-61om170g	77	1	,	,	,
cord-334133-61om170g	77	2	2002	2002	CD
cord-334133-61om170g	77	3	;	;	:
cord-334133-61om170g	77	4	Wyss	Wyss	NNP
cord-334133-61om170g	77	5	et	et	NNP
cord-334133-61om170g	77	6	al	al	NNP
cord-334133-61om170g	77	7	.	.	NNP
cord-334133-61om170g	77	8	,	,	,
cord-334133-61om170g	77	9	2001	2001	CD
cord-334133-61om170g	77	10	)	)	-RRB-
cord-334133-61om170g	77	11	.	.	.
cord-334133-61om170g	78	1	Gp120	Gp120	NNP
cord-334133-61om170g	78	2	is	be	VBZ
cord-334133-61om170g	78	3	the	the	DT
cord-334133-61om170g	78	4	distal	distal	JJ
cord-334133-61om170g	78	5	part	part	NN
cord-334133-61om170g	78	6	of	of	IN
cord-334133-61om170g	78	7	the	the	DT
cord-334133-61om170g	78	8	envelope	envelope	NN
cord-334133-61om170g	78	9	glycoprotein	glycoprotein	NN
cord-334133-61om170g	78	10	trimer	trimer	NN
cord-334133-61om170g	78	11	,	,	,
cord-334133-61om170g	78	12	and	and	CC
cord-334133-61om170g	78	13	recognizes	recognize	VBZ
cord-334133-61om170g	78	14	the	the	DT
cord-334133-61om170g	78	15	primary	primary	JJ
cord-334133-61om170g	78	16	CD4	CD4	NNP
cord-334133-61om170g	78	17	receptor	receptor	NN
cord-334133-61om170g	78	18	,	,	,
cord-334133-61om170g	78	19	and	and	CC
cord-334133-61om170g	78	20	coreceptors	coreceptor	NNS
cord-334133-61om170g	78	21	on	on	IN
cord-334133-61om170g	78	22	the	the	DT
cord-334133-61om170g	78	23	target	target	NN
cord-334133-61om170g	78	24	cell	cell	NN
cord-334133-61om170g	78	25	.	.	.
cord-334133-61om170g	79	1	Gp41	Gp41	NNP
cord-334133-61om170g	79	2	anchors	anchor	NNS
cord-334133-61om170g	79	3	the	the	DT
cord-334133-61om170g	79	4	envelope	envelope	NN
cord-334133-61om170g	79	5	glycoprotein	glycoprotein	NN
cord-334133-61om170g	79	6	in	in	IN
cord-334133-61om170g	79	7	the	the	DT
cord-334133-61om170g	79	8	cell	cell	NN
cord-334133-61om170g	79	9	or	or	CC
cord-334133-61om170g	79	10	virion	virion	NN
cord-334133-61om170g	79	11	membrane	membrane	NN
cord-334133-61om170g	79	12	,	,	,
cord-334133-61om170g	79	13	and	and	CC
cord-334133-61om170g	79	14	mediates	mediate	VBZ
cord-334133-61om170g	79	15	the	the	DT
cord-334133-61om170g	79	16	virion	virion	NN
cord-334133-61om170g	79	17	fusion	fusion	NN
cord-334133-61om170g	79	18	entry	entry	NN
cord-334133-61om170g	79	19	process	process	NN
cord-334133-61om170g	79	20	that	that	WDT
cord-334133-61om170g	79	21	is	be	VBZ
cord-334133-61om170g	79	22	activated	activate	VBN
cord-334133-61om170g	79	23	by	by	IN
cord-334133-61om170g	79	24	receptor	receptor	NN
cord-334133-61om170g	79	25	binding	binding	NN
cord-334133-61om170g	79	26	.	.	.
cord-334133-61om170g	80	1	The	the	DT
cord-334133-61om170g	80	2	N	n	CD
cord-334133-61om170g	80	3	-	-	HYPH
cord-334133-61om170g	80	4	terminal	terminal	NN
cord-334133-61om170g	80	5	peptide	peptide	NN
cord-334133-61om170g	80	6	of	of	IN
cord-334133-61om170g	80	7	gp41	gp41	NNP
cord-334133-61om170g	80	8	is	be	VBZ
cord-334133-61om170g	80	9	inserted	insert	VBN
cord-334133-61om170g	80	10	into	into	IN
cord-334133-61om170g	80	11	the	the	DT
cord-334133-61om170g	80	12	membrane	membrane	NN
cord-334133-61om170g	80	13	of	of	IN
cord-334133-61om170g	80	14	the	the	DT
cord-334133-61om170g	80	15	target	target	NN
cord-334133-61om170g	80	16	cell	cell	NN
cord-334133-61om170g	80	17	and	and	CC
cord-334133-61om170g	80	18	leads	lead	VBZ
cord-334133-61om170g	80	19	to	to	IN
cord-334133-61om170g	80	20	fusion	fusion	NN
cord-334133-61om170g	80	21	of	of	IN
cord-334133-61om170g	80	22	the	the	DT
cord-334133-61om170g	80	23	virion	virion	NN
cord-334133-61om170g	80	24	and	and	CC
cord-334133-61om170g	80	25	cell	cell	NN
cord-334133-61om170g	80	26	membranes	membrane	NNS
cord-334133-61om170g	80	27	,	,	,
cord-334133-61om170g	80	28	entry	entry	NN
cord-334133-61om170g	80	29	of	of	IN
cord-334133-61om170g	80	30	the	the	DT
cord-334133-61om170g	80	31	virus	virus	NN
cord-334133-61om170g	80	32	genome	genome	NN
cord-334133-61om170g	80	33	and	and	CC
cord-334133-61om170g	80	34	associated	associate	VBD
cord-334133-61om170g	80	35	proteins	protein	NNS
cord-334133-61om170g	80	36	into	into	IN
cord-334133-61om170g	80	37	the	the	DT
cord-334133-61om170g	80	38	cell	cell	NN
cord-334133-61om170g	80	39	,	,	,
cord-334133-61om170g	80	40	and	and	CC
cord-334133-61om170g	80	41	infection	infection	NN
cord-334133-61om170g	80	42	.	.	.
cord-334133-61om170g	81	1	Gp41	Gp41	NNP
cord-334133-61om170g	81	2	comprises	comprise	VBZ
cord-334133-61om170g	81	3	an	an	DT
cord-334133-61om170g	81	4	ectodomain	ectodomain	NN
cord-334133-61om170g	81	5	,	,	,
cord-334133-61om170g	81	6	a	a	DT
cord-334133-61om170g	81	7	single	single	JJ
cord-334133-61om170g	81	8	membrane	membrane	NN
cord-334133-61om170g	81	9	-	-	HYPH
cord-334133-61om170g	81	10	spanning	span	VBG
cord-334133-61om170g	81	11	domain	domain	NN
cord-334133-61om170g	81	12	(	(	-LRB-
cord-334133-61om170g	81	13	MSD	MSD	NNP
cord-334133-61om170g	81	14	)	)	-RRB-
cord-334133-61om170g	81	15	,	,	,
cord-334133-61om170g	81	16	and	and	CC
cord-334133-61om170g	81	17	a	a	DT
cord-334133-61om170g	81	18	long	long	JJ
cord-334133-61om170g	81	19	C	c	NN
cord-334133-61om170g	81	20	-	-	HYPH
cord-334133-61om170g	81	21	terminal	terminal	NN
cord-334133-61om170g	81	22	tail	tail	NN
cord-334133-61om170g	81	23	that	that	IN
cord-334133-61om170g	81	24	in	in	IN
cord-334133-61om170g	81	25	the	the	DT
cord-334133-61om170g	81	26	past	past	NN
cord-334133-61om170g	81	27	has	have	VBZ
cord-334133-61om170g	81	28	been	be	VBN
cord-334133-61om170g	81	29	viewed	view	VBN
cord-334133-61om170g	81	30	as	as	IN
cord-334133-61om170g	81	31	being	be	VBG
cord-334133-61om170g	81	32	entirely	entirely	RB
cord-334133-61om170g	81	33	contained	contain	VBN
cord-334133-61om170g	81	34	inside	inside	IN
cord-334133-61om170g	81	35	the	the	DT
cord-334133-61om170g	81	36	cell	cell	NN
cord-334133-61om170g	81	37	or	or	CC
cord-334133-61om170g	81	38	virion	virion	NN
cord-334133-61om170g	81	39	(	(	-LRB-
cord-334133-61om170g	81	40	Gallaher	Gallaher	NNP
cord-334133-61om170g	81	41	,	,	,
cord-334133-61om170g	81	42	1987	1987	CD
cord-334133-61om170g	81	43	;	;	:
cord-334133-61om170g	81	44	Gallaher	Gallaher	NNP
cord-334133-61om170g	81	45	et	et	NNP
cord-334133-61om170g	81	46	al	al	NNP
cord-334133-61om170g	81	47	.	.	NNP
cord-334133-61om170g	81	48	,	,	,
cord-334133-61om170g	81	49	1989	1989	CD
cord-334133-61om170g	81	50	;	;	:
cord-334133-61om170g	81	51	Gonzalez	Gonzalez	NNP
cord-334133-61om170g	81	52	-	-	HYPH
cord-334133-61om170g	81	53	Scarano	Scarano	NNP
cord-334133-61om170g	81	54	et	et	NNP
cord-334133-61om170g	81	55	al	al	NNP
cord-334133-61om170g	81	56	.	.	NNP
cord-334133-61om170g	81	57	,	,	,
cord-334133-61om170g	81	58	1987	1987	CD
cord-334133-61om170g	81	59	;	;	:
cord-334133-61om170g	81	60	Levy	Levy	NNP
cord-334133-61om170g	81	61	,	,	,
cord-334133-61om170g	81	62	1998	1998	CD
cord-334133-61om170g	81	63	;	;	:
cord-334133-61om170g	81	64	White	White	NNP
cord-334133-61om170g	81	65	,	,	,
cord-334133-61om170g	81	66	1990	1990	CD
cord-334133-61om170g	81	67	)	)	-RRB-
cord-334133-61om170g	81	68	.	.	.
cord-334133-61om170g	82	1	However	however	RB
cord-334133-61om170g	82	2	,	,	,
cord-334133-61om170g	82	3	there	there	EX
cord-334133-61om170g	82	4	is	be	VBZ
cord-334133-61om170g	82	5	abundant	abundant	JJ
cord-334133-61om170g	82	6	evidence	evidence	NN
cord-334133-61om170g	82	7	that	that	IN
cord-334133-61om170g	82	8	HIV-1	HIV-1	NNP
cord-334133-61om170g	82	9	virions	virion	NNS
cord-334133-61om170g	82	10	can	can	MD
cord-334133-61om170g	82	11	be	be	VB
cord-334133-61om170g	82	12	neutralized	neutralize	VBN
cord-334133-61om170g	82	13	by	by	IN
cord-334133-61om170g	82	14	antibodies	antibody	NNS
cord-334133-61om170g	82	15	directed	direct	VBN
cord-334133-61om170g	82	16	to	to	IN
cord-334133-61om170g	82	17	an	an	DT
cord-334133-61om170g	82	18	epitope	epitope	NN
cord-334133-61om170g	82	19	in	in	IN
cord-334133-61om170g	82	20	the	the	DT
cord-334133-61om170g	82	21	Cterminal	Cterminal	NNP
cord-334133-61om170g	82	22	tail	tail	NN
cord-334133-61om170g	83	1	(	(	-LRB-
cord-334133-61om170g	83	2	Buratti	Buratti	NNP
cord-334133-61om170g	83	3	et	et	NNP
cord-334133-61om170g	83	4	al	al	NNP
cord-334133-61om170g	83	5	.	.	NNP
cord-334133-61om170g	83	6	,	,	,
cord-334133-61om170g	83	7	1998	1998	CD
cord-334133-61om170g	83	8	;	;	:
cord-334133-61om170g	83	9	Chanh	Chanh	NNP
cord-334133-61om170g	83	10	et	et	NNP
cord-334133-61om170g	83	11	al	al	NNP
cord-334133-61om170g	83	12	.	.	NNP
cord-334133-61om170g	83	13	,	,	,
cord-334133-61om170g	83	14	1986	1986	CD
cord-334133-61om170g	83	15	;	;	:
cord-334133-61om170g	83	16	Cleveland	Cleveland	NNP
cord-334133-61om170g	83	17	et	et	NNP
cord-334133-61om170g	83	18	al	al	NNP
cord-334133-61om170g	83	19	.	.	.
cord-334133-61om170g	84	1	,	,	,
cord-334133-61om170g	84	2	2000a	2000a	CD
cord-334133-61om170g	85	1	Cleveland	Cleveland	NNP
cord-334133-61om170g	85	2	et	et	NNP
cord-334133-61om170g	85	3	al	al	NNP
cord-334133-61om170g	85	4	.	.	.
cord-334133-61om170g	86	1	,	,	,
cord-334133-61om170g	86	2	,	,	,
cord-334133-61om170g	86	3	b	b	NN
cord-334133-61om170g	86	4	,	,	,
cord-334133-61om170g	86	5	2003	2003	CD
cord-334133-61om170g	86	6	Dalgleish	Dalgleish	NNP
cord-334133-61om170g	86	7	et	et	FW
cord-334133-61om170g	86	8	al	al	NNP
cord-334133-61om170g	86	9	.	.	.
cord-334133-61om170g	87	1	,	,	,
cord-334133-61om170g	87	2	1988	1988	CD
cord-334133-61om170g	87	3	;	;	:
cord-334133-61om170g	87	4	Durrani	Durrani	NNP
cord-334133-61om170g	87	5	et	et	NNP
cord-334133-61om170g	87	6	al	al	NNP
cord-334133-61om170g	87	7	.	.	NNP
cord-334133-61om170g	87	8	,	,	,
cord-334133-61om170g	87	9	1998	1998	CD
cord-334133-61om170g	87	10	;	;	:
cord-334133-61om170g	88	1	Ho	Ho	NNP
cord-334133-61om170g	88	2	et	et	FW
cord-334133-61om170g	88	3	al	al	NNP
cord-334133-61om170g	88	4	.	.	NNP
cord-334133-61om170g	88	5	,	,	,
cord-334133-61om170g	88	6	1987	1987	CD
cord-334133-61om170g	88	7	;	;	:
cord-334133-61om170g	88	8	McInerney	McInerney	NNP
cord-334133-61om170g	88	9	et	et	NNP
cord-334133-61om170g	88	10	al	al	NNP
cord-334133-61om170g	88	11	.	.	NNP
cord-334133-61om170g	88	12	,	,	,
cord-334133-61om170g	88	13	1999	1999	CD
cord-334133-61om170g	89	1	;	;	:
cord-334133-61om170g	89	2	McLain	McLain	NNP
cord-334133-61om170g	89	3	et	et	NNP
cord-334133-61om170g	89	4	al	al	NNP
cord-334133-61om170g	89	5	.	.	.
cord-334133-61om170g	90	1	,	,	,
cord-334133-61om170g	90	2	1995	1995	CD
cord-334133-61om170g	91	1	McLain	McLain	NNP
cord-334133-61om170g	91	2	et	et	NNP
cord-334133-61om170g	91	3	al	al	NNP
cord-334133-61om170g	91	4	.	.	.
cord-334133-61om170g	92	1	,	,	,
cord-334133-61om170g	92	2	,	,	,
cord-334133-61om170g	92	3	1996	1996	CD
cord-334133-61om170g	92	4	McLain	McLain	NNP
cord-334133-61om170g	92	5	et	et	NNP
cord-334133-61om170g	92	6	al	al	NNP
cord-334133-61om170g	92	7	.	.	.
cord-334133-61om170g	93	1	,	,	,
cord-334133-61om170g	93	2	,	,	,
cord-334133-61om170g	93	3	2001	2001	CD
cord-334133-61om170g	93	4	Newton	Newton	NNP
cord-334133-61om170g	93	5	et	et	NNP
cord-334133-61om170g	93	6	al	al	NNP
cord-334133-61om170g	93	7	.	.	NNP
cord-334133-61om170g	93	8	,	,	,
cord-334133-61om170g	93	9	1995	1995	CD
cord-334133-61om170g	93	10	;	;	:
cord-334133-61om170g	93	11	Reading	read	VBG
cord-334133-61om170g	93	12	et	et	FW
cord-334133-61om170g	93	13	al	al	NNP
cord-334133-61om170g	93	14	.	.	NNP
cord-334133-61om170g	93	15	,	,	,
cord-334133-61om170g	93	16	2003	2003	CD
cord-334133-61om170g	93	17	)	)	-RRB-
cord-334133-61om170g	93	18	.	.	.
cord-334133-61om170g	94	1	Since	since	IN
cord-334133-61om170g	94	2	antibodies	antibody	NNS
cord-334133-61om170g	94	3	do	do	VBP
cord-334133-61om170g	94	4	not	not	RB
cord-334133-61om170g	94	5	cross	cross	VB
cord-334133-61om170g	94	6	lipid	lipid	NN
cord-334133-61om170g	94	7	bilayers	bilayer	NNS
cord-334133-61om170g	94	8	,	,	,
cord-334133-61om170g	94	9	this	this	DT
cord-334133-61om170g	94	10	means	mean	VBZ
cord-334133-61om170g	94	11	that	that	IN
cord-334133-61om170g	94	12	part	part	NN
cord-334133-61om170g	94	13	of	of	IN
cord-334133-61om170g	94	14	the	the	DT
cord-334133-61om170g	94	15	tail	tail	NN
cord-334133-61om170g	94	16	is	be	VBZ
cord-334133-61om170g	94	17	exposed	expose	VBN
cord-334133-61om170g	94	18	on	on	IN
cord-334133-61om170g	94	19	the	the	DT
cord-334133-61om170g	94	20	virion	virion	NN
cord-334133-61om170g	94	21	surface	surface	NN
cord-334133-61om170g	94	22	.	.	.
cord-334133-61om170g	95	1	We	-PRON-	PRP
cord-334133-61om170g	95	2	have	have	VBP
cord-334133-61om170g	95	3	called	call	VBN
cord-334133-61om170g	95	4	this	this	DT
cord-334133-61om170g	95	5	exposed	expose	VBN
cord-334133-61om170g	95	6	region	region	NN
cord-334133-61om170g	95	7	of	of	IN
cord-334133-61om170g	95	8	the	the	DT
cord-334133-61om170g	95	9	gp41	gp41	NNP
cord-334133-61om170g	95	10	tail	tail	VB
cord-334133-61om170g	95	11	the	the	DT
cord-334133-61om170g	95	12	minor	minor	JJ
cord-334133-61om170g	95	13	ectodomain	ectodomain	NN
cord-334133-61om170g	95	14	,	,	,
cord-334133-61om170g	95	15	to	to	TO
cord-334133-61om170g	95	16	distinguish	distinguish	VB
cord-334133-61om170g	95	17	it	-PRON-	PRP
cord-334133-61om170g	95	18	from	from	IN
cord-334133-61om170g	95	19	the	the	DT
cord-334133-61om170g	95	20	better	well	RBR
cord-334133-61om170g	95	21	known	know	VBN
cord-334133-61om170g	95	22	,	,	,
cord-334133-61om170g	95	23	and	and	CC
cord-334133-61om170g	95	24	larger	large	JJR
cord-334133-61om170g	95	25	,	,	,
cord-334133-61om170g	95	26	major	major	JJ
cord-334133-61om170g	95	27	ectodomain	ectodomain	NN
cord-334133-61om170g	95	28	.	.	.
cord-334133-61om170g	96	1	Non	non	JJ
cord-334133-61om170g	96	2	-	-	JJ
cord-334133-61om170g	96	3	neutralizing	neutralize	VBG
cord-334133-61om170g	96	4	antibodies	antibody	NNS
cord-334133-61om170g	96	5	specific	specific	JJ
cord-334133-61om170g	96	6	for	for	IN
cord-334133-61om170g	96	7	the	the	DT
cord-334133-61om170g	96	8	minor	minor	JJ
cord-334133-61om170g	96	9	ectodomain	ectodomain	NN
cord-334133-61om170g	96	10	have	have	VBP
cord-334133-61om170g	96	11	also	also	RB
cord-334133-61om170g	96	12	been	be	VBN
cord-334133-61om170g	96	13	shown	show	VBN
cord-334133-61om170g	96	14	to	to	TO
cord-334133-61om170g	96	15	bind	bind	VB
cord-334133-61om170g	96	16	virions	virion	NNS
cord-334133-61om170g	96	17	(	(	-LRB-
cord-334133-61om170g	96	18	Cleveland	Cleveland	NNP
cord-334133-61om170g	96	19	et	et	NNP
cord-334133-61om170g	96	20	al	al	NNP
cord-334133-61om170g	96	21	.	.	NNP
cord-334133-61om170g	96	22	,	,	,
cord-334133-61om170g	96	23	2003	2003	CD
cord-334133-61om170g	96	24	;	;	:
cord-334133-61om170g	96	25	McLain	McLain	NNP
cord-334133-61om170g	96	26	et	et	NNP
cord-334133-61om170g	96	27	al	al	NNP
cord-334133-61om170g	96	28	.	.	NNP
cord-334133-61om170g	96	29	,	,	,
cord-334133-61om170g	96	30	2001	2001	CD
cord-334133-61om170g	96	31	)	)	-RRB-
cord-334133-61om170g	96	32	,	,	,
cord-334133-61om170g	96	33	providing	provide	VBG
cord-334133-61om170g	96	34	further	further	JJ
cord-334133-61om170g	96	35	evidence	evidence	NN
cord-334133-61om170g	96	36	of	of	IN
cord-334133-61om170g	96	37	the	the	DT
cord-334133-61om170g	96	38	externalization	externalization	NN
cord-334133-61om170g	96	39	of	of	IN
cord-334133-61om170g	96	40	the	the	DT
cord-334133-61om170g	96	41	minor	minor	JJ
cord-334133-61om170g	96	42	ectodomain	ectodomain	NN
cord-334133-61om170g	96	43	.	.	.
cord-334133-61om170g	97	1	Binding	bind	VBG
cord-334133-61om170g	97	2	of	of	IN
cord-334133-61om170g	97	3	antibody	antibody	NN
cord-334133-61om170g	97	4	is	be	VBZ
cord-334133-61om170g	97	5	abrogated	abrogate	VBN
cord-334133-61om170g	97	6	by	by	IN
cord-334133-61om170g	97	7	pre	pre	JJ
cord-334133-61om170g	97	8	-	-	NN
cord-334133-61om170g	97	9	treatment	treatment	NN
cord-334133-61om170g	97	10	of	of	IN
cord-334133-61om170g	97	11	virions	virion	NNS
cord-334133-61om170g	97	12	with	with	IN
cord-334133-61om170g	97	13	protease	protease	NN
cord-334133-61om170g	97	14	,	,	,
cord-334133-61om170g	97	15	again	again	RB
cord-334133-61om170g	97	16	supporting	support	VBG
cord-334133-61om170g	97	17	the	the	DT
cord-334133-61om170g	97	18	external	external	JJ
cord-334133-61om170g	97	19	location	location	NN
cord-334133-61om170g	97	20	of	of	IN
cord-334133-61om170g	97	21	this	this	DT
cord-334133-61om170g	97	22	part	part	NN
cord-334133-61om170g	97	23	of	of	IN
cord-334133-61om170g	97	24	the	the	DT
cord-334133-61om170g	97	25	tail	tail	NN
cord-334133-61om170g	98	1	(	(	-LRB-
cord-334133-61om170g	98	2	Cleveland	Cleveland	NNP
cord-334133-61om170g	98	3	et	et	NNP
cord-334133-61om170g	98	4	al	al	NNP
cord-334133-61om170g	98	5	.	.	NNP
cord-334133-61om170g	98	6	,	,	,
cord-334133-61om170g	98	7	2003	2003	CD
cord-334133-61om170g	98	8	)	)	-RRB-
cord-334133-61om170g	98	9	.	.	.
cord-334133-61om170g	99	1	More	more	RBR
cord-334133-61om170g	99	2	recently	recently	RB
cord-334133-61om170g	99	3	,	,	,
cord-334133-61om170g	99	4	we	-PRON-	PRP
cord-334133-61om170g	99	5	demonstrated	demonstrate	VBD
cord-334133-61om170g	99	6	for	for	IN
cord-334133-61om170g	99	7	the	the	DT
cord-334133-61om170g	99	8	first	first	JJ
cord-334133-61om170g	99	9	time	time	NN
cord-334133-61om170g	99	10	that	that	IN
cord-334133-61om170g	99	11	neutralizing	neutralize	VBG
cord-334133-61om170g	99	12	and	and	CC
cord-334133-61om170g	99	13	non	non	JJ
cord-334133-61om170g	99	14	-	-	JJ
cord-334133-61om170g	99	15	neutralizing	neutralize	VBG
cord-334133-61om170g	99	16	antibodies	antibody	NNS
cord-334133-61om170g	99	17	to	to	IN
cord-334133-61om170g	99	18	the	the	DT
cord-334133-61om170g	99	19	minor	minor	JJ
cord-334133-61om170g	99	20	ectodomain	ectodomain	NN
cord-334133-61om170g	99	21	bind	bind	NN
cord-334133-61om170g	99	22	to	to	IN
cord-334133-61om170g	99	23	infected	infected	JJ
cord-334133-61om170g	99	24	cells	cell	NNS
cord-334133-61om170g	99	25	and	and	CC
cord-334133-61om170g	99	26	that	that	IN
cord-334133-61om170g	99	27	the	the	DT
cord-334133-61om170g	99	28	neutralizing	neutralize	VBG
cord-334133-61om170g	99	29	antibodies	antibody	NNS
cord-334133-61om170g	99	30	inhibit	inhibit	VBP
cord-334133-61om170g	99	31	fusion	fusion	NN
cord-334133-61om170g	99	32	of	of	IN
cord-334133-61om170g	99	33	infected	infected	JJ
cord-334133-61om170g	99	34	and	and	CC
cord-334133-61om170g	99	35	non	non	JJ
cord-334133-61om170g	99	36	-	-	JJ
cord-334133-61om170g	99	37	infected	infected	JJ
cord-334133-61om170g	99	38	cells	cell	NNS
cord-334133-61om170g	99	39	(	(	-LRB-
cord-334133-61om170g	99	40	Cheung	Cheung	NNP
cord-334133-61om170g	99	41	et	et	NNP
cord-334133-61om170g	99	42	al	al	NNP
cord-334133-61om170g	99	43	.	.	NNP
cord-334133-61om170g	99	44	,	,	,
cord-334133-61om170g	99	45	2005	2005	CD
cord-334133-61om170g	99	46	;	;	:
cord-334133-61om170g	99	47	Heap	Heap	NNP
cord-334133-61om170g	99	48	et	et	NNP
cord-334133-61om170g	99	49	al	al	NNP
cord-334133-61om170g	99	50	.	.	NNP
cord-334133-61om170g	99	51	,	,	,
cord-334133-61om170g	99	52	2005	2005	CD
cord-334133-61om170g	99	53	)	)	-RRB-
cord-334133-61om170g	99	54	.	.	.
cord-334133-61om170g	100	1	Thus	thus	RB
cord-334133-61om170g	100	2	,	,	,
cord-334133-61om170g	100	3	part	part	NN
cord-334133-61om170g	100	4	of	of	IN
cord-334133-61om170g	100	5	the	the	DT
cord-334133-61om170g	100	6	gp41	gp41	NNP
cord-334133-61om170g	100	7	C	c	NN
cord-334133-61om170g	100	8	-	-	HYPH
cord-334133-61om170g	100	9	terminal	terminal	NN
cord-334133-61om170g	100	10	tail	tail	NN
cord-334133-61om170g	100	11	is	be	VBZ
cord-334133-61om170g	100	12	exposed	expose	VBN
cord-334133-61om170g	100	13	on	on	IN
cord-334133-61om170g	100	14	the	the	DT
cord-334133-61om170g	100	15	surface	surface	NN
cord-334133-61om170g	100	16	of	of	IN
cord-334133-61om170g	100	17	both	both	DT
cord-334133-61om170g	100	18	infected	infected	JJ
cord-334133-61om170g	100	19	cells	cell	NNS
cord-334133-61om170g	100	20	and	and	CC
cord-334133-61om170g	100	21	virions	virion	NNS
cord-334133-61om170g	100	22	.	.	.
cord-334133-61om170g	101	1	Until	until	IN
cord-334133-61om170g	101	2	now	now	RB
cord-334133-61om170g	101	3	,	,	,
cord-334133-61om170g	101	4	evidence	evidence	NN
cord-334133-61om170g	101	5	for	for	IN
cord-334133-61om170g	101	6	the	the	DT
cord-334133-61om170g	101	7	exposure	exposure	NN
cord-334133-61om170g	101	8	of	of	IN
cord-334133-61om170g	101	9	part	part	NN
cord-334133-61om170g	101	10	of	of	IN
cord-334133-61om170g	101	11	the	the	DT
cord-334133-61om170g	101	12	gp41	gp41	NNP
cord-334133-61om170g	101	13	C	c	NN
cord-334133-61om170g	101	14	-	-	HYPH
cord-334133-61om170g	101	15	terminal	terminal	NN
cord-334133-61om170g	101	16	tail	tail	NN
cord-334133-61om170g	101	17	has	have	VBZ
cord-334133-61om170g	101	18	been	be	VBN
cord-334133-61om170g	101	19	based	base	VBN
cord-334133-61om170g	101	20	on	on	IN
cord-334133-61om170g	101	21	the	the	DT
cord-334133-61om170g	101	22	study	study	NN
cord-334133-61om170g	101	23	of	of	IN
cord-334133-61om170g	101	24	HIV-1	HIV-1	NNP
cord-334133-61om170g	101	25	B	B	NNP
cord-334133-61om170g	101	26	clade	clade	NN
cord-334133-61om170g	101	27	,	,	,
cord-334133-61om170g	101	28	T	t	NN
cord-334133-61om170g	101	29	cell	cell	NN
cord-334133-61om170g	101	30	line	line	NN
cord-334133-61om170g	101	31	-	-	HYPH
cord-334133-61om170g	101	32	adapted	adapt	VBN
cord-334133-61om170g	101	33	(	(	-LRB-
cord-334133-61om170g	101	34	TCLA	TCLA	NNP
cord-334133-61om170g	101	35	)	)	-RRB-
cord-334133-61om170g	101	36	viruses	virus	NNS
cord-334133-61om170g	101	37	,	,	,
cord-334133-61om170g	101	38	and	and	CC
cord-334133-61om170g	101	39	the	the	DT
cord-334133-61om170g	101	40	generality	generality	NN
cord-334133-61om170g	101	41	of	of	IN
cord-334133-61om170g	101	42	the	the	DT
cord-334133-61om170g	101	43	existence	existence	NN
cord-334133-61om170g	101	44	of	of	IN
cord-334133-61om170g	101	45	the	the	DT
cord-334133-61om170g	101	46	minor	minor	JJ
cord-334133-61om170g	101	47	ectodomain	ectodomain	NN
cord-334133-61om170g	101	48	,	,	,
cord-334133-61om170g	101	49	and	and	CC
cord-334133-61om170g	101	50	its	-PRON-	PRP$
cord-334133-61om170g	101	51	structural	structural	JJ
cord-334133-61om170g	101	52	basis	basis	NN
cord-334133-61om170g	101	53	,	,	,
cord-334133-61om170g	101	54	have	have	VBP
cord-334133-61om170g	101	55	not	not	RB
cord-334133-61om170g	101	56	been	be	VBN
cord-334133-61om170g	101	57	explored	explore	VBN
cord-334133-61om170g	101	58	.	.	.
cord-334133-61om170g	102	1	To	to	TO
cord-334133-61om170g	102	2	remedy	remedy	VB
cord-334133-61om170g	102	3	this	this	DT
cord-334133-61om170g	102	4	,	,	,
cord-334133-61om170g	102	5	we	-PRON-	PRP
cord-334133-61om170g	102	6	have	have	VBP
cord-334133-61om170g	102	7	here	here	RB
cord-334133-61om170g	102	8	analyzed	analyze	VBN
cord-334133-61om170g	102	9	357	357	CD
cord-334133-61om170g	102	10	gp41	gp41	NN
cord-334133-61om170g	102	11	C	c	NN
cord-334133-61om170g	102	12	-	-	HYPH
cord-334133-61om170g	102	13	terminal	terminal	NN
cord-334133-61om170g	102	14	tail	tail	NN
cord-334133-61om170g	102	15	database	database	NN
cord-334133-61om170g	102	16	sequences	sequence	NNS
cord-334133-61om170g	102	17	from	from	IN
cord-334133-61om170g	102	18	clades	clade	NNS
cord-334133-61om170g	102	19	A	A	NNP
cord-334133-61om170g	102	20	,	,	,
cord-334133-61om170g	102	21	B	b	NN
cord-334133-61om170g	102	22	,	,	,
cord-334133-61om170g	102	23	C	C	NNP
cord-334133-61om170g	102	24	,	,	,
cord-334133-61om170g	102	25	and	and	CC
cord-334133-61om170g	103	1	D.	D.	NNP
cord-334133-61om170g	103	2	This	this	DT
cord-334133-61om170g	103	3	analysis	analysis	NN
cord-334133-61om170g	103	4	shows	show	VBZ
cord-334133-61om170g	103	5	that	that	IN
cord-334133-61om170g	103	6	all	all	PDT
cord-334133-61om170g	103	7	these	these	DT
cord-334133-61om170g	103	8	could	could	MD
cord-334133-61om170g	103	9	potentially	potentially	RB
cord-334133-61om170g	103	10	have	have	VB
cord-334133-61om170g	103	11	a	a	DT
cord-334133-61om170g	103	12	minor	minor	JJ
cord-334133-61om170g	103	13	ectodomain	ectodomain	NN
cord-334133-61om170g	103	14	of	of	IN
cord-334133-61om170g	103	15	approximately	approximately	RB
cord-334133-61om170g	103	16	40	40	CD
cord-334133-61om170g	103	17	residues	residue	NNS
cord-334133-61om170g	103	18	,	,	,
cord-334133-61om170g	103	19	supported	support	VBN
cord-334133-61om170g	103	20	by	by	IN
cord-334133-61om170g	103	21	three	three	CD
cord-334133-61om170g	103	22	MSDs	msd	NNS
cord-334133-61om170g	103	23	,	,	,
cord-334133-61om170g	103	24	and	and	CC
cord-334133-61om170g	103	25	an	an	DT
cord-334133-61om170g	103	26	internal	internal	JJ
cord-334133-61om170g	103	27	tail	tail	NN
cord-334133-61om170g	103	28	of	of	IN
cord-334133-61om170g	103	29	approximately	approximately	RB
cord-334133-61om170g	103	30	100	100	CD
cord-334133-61om170g	103	31	residues	residue	NNS
cord-334133-61om170g	103	32	.	.	.
cord-334133-61om170g	104	1	We	-PRON-	PRP
cord-334133-61om170g	104	2	shall	shall	MD
cord-334133-61om170g	104	3	further	further	RB
cord-334133-61om170g	104	4	suggest	suggest	VB
cord-334133-61om170g	104	5	that	that	IN
cord-334133-61om170g	104	6	this	this	DT
cord-334133-61om170g	104	7	3-MSD	3-msd	CD
cord-334133-61om170g	104	8	form	form	NN
cord-334133-61om170g	104	9	of	of	IN
cord-334133-61om170g	104	10	gp41	gp41	NN
cord-334133-61om170g	104	11	coexists	coexist	VBZ
cord-334133-61om170g	104	12	with	with	IN
cord-334133-61om170g	104	13	the	the	DT
cord-334133-61om170g	104	14	accepted	accept	VBN
cord-334133-61om170g	104	15	1-MSD	1-msd	CD
cord-334133-61om170g	104	16	form	form	NN
cord-334133-61om170g	104	17	of	of	IN
cord-334133-61om170g	104	18	gp41	gp41	NNP
cord-334133-61om170g	104	19	,	,	,
cord-334133-61om170g	104	20	and	and	CC
cord-334133-61om170g	104	21	that	that	IN
cord-334133-61om170g	104	22	the	the	DT
cord-334133-61om170g	104	23	3-MSD	3-msd	CD
cord-334133-61om170g	104	24	form	form	NN
cord-334133-61om170g	104	25	represents	represent	VBZ
cord-334133-61om170g	104	26	a	a	DT
cord-334133-61om170g	104	27	minor	minor	JJ
cord-334133-61om170g	104	28	population	population	NN
cord-334133-61om170g	104	29	of	of	IN
cord-334133-61om170g	104	30	intracellular	intracellular	JJ
cord-334133-61om170g	104	31	gp41	gp41	NN
cord-334133-61om170g	104	32	that	that	WDT
cord-334133-61om170g	104	33	is	be	VBZ
cord-334133-61om170g	104	34	destined	destine	VBN
cord-334133-61om170g	104	35	for	for	IN
cord-334133-61om170g	104	36	incorporation	incorporation	NN
cord-334133-61om170g	104	37	into	into	IN
cord-334133-61om170g	104	38	virions	virion	NNS
cord-334133-61om170g	104	39	.	.	.
cord-334133-61om170g	105	1	In	in	IN
cord-334133-61om170g	105	2	contrast	contrast	NN
cord-334133-61om170g	105	3	,	,	,
cord-334133-61om170g	105	4	1-MSD	1-msd	CD
cord-334133-61om170g	105	5	gp41	gp41	NNP
cord-334133-61om170g	105	6	is	be	VBZ
cord-334133-61om170g	105	7	the	the	DT
cord-334133-61om170g	105	8	majority	majority	NN
cord-334133-61om170g	105	9	form	form	NN
cord-334133-61om170g	105	10	of	of	IN
cord-334133-61om170g	105	11	intracellular	intracellular	JJ
cord-334133-61om170g	105	12	gp41	gp41	NN
cord-334133-61om170g	105	13	,	,	,
cord-334133-61om170g	105	14	most	most	JJS
cord-334133-61om170g	105	15	of	of	IN
cord-334133-61om170g	105	16	which	which	WDT
cord-334133-61om170g	105	17	is	be	VBZ
cord-334133-61om170g	105	18	degraded	degrade	VBN
cord-334133-61om170g	105	19	.	.	.
cord-334133-61om170g	106	1	Regions	region	NNS
cord-334133-61om170g	106	2	of	of	IN
cord-334133-61om170g	106	3	conservation	conservation	NN
cord-334133-61om170g	106	4	in	in	IN
cord-334133-61om170g	106	5	the	the	DT
cord-334133-61om170g	106	6	gp41	gp41	NNP
cord-334133-61om170g	106	7	sequence	sequence	NN
cord-334133-61om170g	107	1	690	690	CD
cord-334133-61om170g	107	2	-793	-793	NN
cord-334133-61om170g	107	3	of	of	IN
cord-334133-61om170g	108	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	108	2	clades	clade	NNS
cord-334133-61om170g	108	3	A	a	DT
cord-334133-61om170g	108	4	to	to	IN
cord-334133-61om170g	108	5	D	D	NNP
cord-334133-61om170g	108	6	are	be	VBP
cord-334133-61om170g	108	7	summarized	summarize	VBN
cord-334133-61om170g	108	8	in	in	IN
cord-334133-61om170g	108	9	Fig	Fig	NNP
cord-334133-61om170g	108	10	.	.	.
cord-334133-61om170g	109	1	1	1	LS
cord-334133-61om170g	109	2	,	,	,
cord-334133-61om170g	109	3	with	with	IN
cord-334133-61om170g	109	4	residues	residue	NNS
cord-334133-61om170g	109	5	numbered	number	VBN
cord-334133-61om170g	109	6	according	accord	VBG
cord-334133-61om170g	109	7	to	to	IN
cord-334133-61om170g	109	8	Ratner	Ratner	NNP
cord-334133-61om170g	109	9	et	et	NNP
cord-334133-61om170g	109	10	al	al	NNP
cord-334133-61om170g	109	11	.	.	.
cord-334133-61om170g	110	1	(	(	-LRB-
cord-334133-61om170g	110	2	1985	1985	CD
cord-334133-61om170g	110	3	)	)	-RRB-
cord-334133-61om170g	110	4	.	.	.
cord-334133-61om170g	111	1	The	the	DT
cord-334133-61om170g	111	2	only	only	JJ
cord-334133-61om170g	111	3	very	very	RB
cord-334133-61om170g	111	4	highly	highly	RB
cord-334133-61om170g	111	5	conserved	conserve	VBN
cord-334133-61om170g	111	6	region	region	NN
cord-334133-61om170g	111	7	throughout	throughout	IN
cord-334133-61om170g	111	8	all	all	DT
cord-334133-61om170g	111	9	clades	clade	NNS
cord-334133-61om170g	111	10	is	be	VBZ
cord-334133-61om170g	111	11	713	713	CD
cord-334133-61om170g	111	12	NRVRQGYSPLSFQ	NRVRQGYSPLSFQ	NNP
cord-334133-61om170g	111	13	725	725	CD
cord-334133-61om170g	111	14	,	,	,
cord-334133-61om170g	111	15	which	which	WDT
cord-334133-61om170g	111	16	contains	contain	VBZ
cord-334133-61om170g	111	17	the	the	DT
cord-334133-61om170g	111	18	most	most	JJS
cord-334133-61om170g	111	19	N	n	CD
cord-334133-61om170g	111	20	-	-	HYPH
cord-334133-61om170g	111	21	terminal	terminal	NN
cord-334133-61om170g	111	22	(	(	-LRB-
cord-334133-61om170g	111	23	first	first	JJ
cord-334133-61om170g	111	24	)	)	-RRB-
cord-334133-61om170g	111	25	tyrosine	tyrosine	NN
cord-334133-61om170g	111	26	-	-	HYPH
cord-334133-61om170g	111	27	dependent	dependent	JJ
cord-334133-61om170g	111	28	sorting	sorting	NN
cord-334133-61om170g	111	29	signal	signal	NN
cord-334133-61om170g	111	30	(	(	-LRB-
cord-334133-61om170g	111	31	719	719	CD
cord-334133-61om170g	111	32	YSPL	YSPL	NNP
cord-334133-61om170g	111	33	722	722	CD
cord-334133-61om170g	111	34	)	)	-RRB-
cord-334133-61om170g	111	35	.	.	.
cord-334133-61om170g	112	1	As	as	IN
cord-334133-61om170g	112	2	expected	expect	VBN
cord-334133-61om170g	112	3	,	,	,
cord-334133-61om170g	112	4	the	the	DT
cord-334133-61om170g	112	5	region	region	NN
cord-334133-61om170g	112	6	comprising	comprise	VBG
cord-334133-61om170g	112	7	the	the	DT
cord-334133-61om170g	112	8	accepted	accept	VBN
cord-334133-61om170g	112	9	MSD	MSD	NNP
cord-334133-61om170g	112	10	,	,	,
cord-334133-61om170g	112	11	690	690	CD
cord-334133-61om170g	112	12	KIFIMIVGGLIGLRIVFAVLSIV	KIFIMIVGGLIGLRIVFAVLSIV	NNP
cord-334133-61om170g	112	13	712	712	CD
cord-334133-61om170g	112	14	,	,	,
cord-334133-61om170g	112	15	is	be	VBZ
cord-334133-61om170g	112	16	highly	highly	RB
cord-334133-61om170g	112	17	conserved	conserve	VBN
cord-334133-61om170g	112	18	and	and	CC
cord-334133-61om170g	112	19	forms	form	NNS
cord-334133-61om170g	112	20	part	part	NN
cord-334133-61om170g	112	21	of	of	IN
cord-334133-61om170g	112	22	a	a	DT
cord-334133-61om170g	112	23	larger	large	JJR
cord-334133-61om170g	112	24	highly	highly	RB
cord-334133-61om170g	112	25	conserved	conserve	VBN
cord-334133-61om170g	112	26	sequence	sequence	NN
cord-334133-61om170g	112	27	690	690	CD
cord-334133-61om170g	112	28	KIFIMIVGGLIGLRIVFAVLSIVNRVRQ	KIFIMIVGGLIGLRIVFAVLSIVNRVRQ	NNP
cord-334133-61om170g	112	29	-	-	HYPH
cord-334133-61om170g	112	30	GYSPLSFQ	GYSPLSFQ	NNP
cord-334133-61om170g	112	31	725	725	CD
cord-334133-61om170g	112	32	,	,	,
cord-334133-61om170g	112	33	which	which	WDT
cord-334133-61om170g	112	34	includes	include	VBZ
cord-334133-61om170g	112	35	the	the	DT
cord-334133-61om170g	112	36	region	region	NN
cord-334133-61om170g	112	37	surrounding	surround	VBG
cord-334133-61om170g	112	38	the	the	DT
cord-334133-61om170g	112	39	first	first	JJ
cord-334133-61om170g	112	40	tyrosine	tyrosine	NN
cord-334133-61om170g	112	41	-	-	HYPH
cord-334133-61om170g	112	42	dependent	dependent	JJ
cord-334133-61om170g	112	43	sorting	sorting	NN
cord-334133-61om170g	112	44	signal	signal	NN
cord-334133-61om170g	112	45	.	.	.
cord-334133-61om170g	113	1	However	however	RB
cord-334133-61om170g	113	2	,	,	,
cord-334133-61om170g	113	3	there	there	EX
cord-334133-61om170g	113	4	are	be	VBP
cord-334133-61om170g	113	5	conservative	conservative	JJ
cord-334133-61om170g	113	6	substitutions	substitution	NNS
cord-334133-61om170g	113	7	in	in	IN
cord-334133-61om170g	113	8	individual	individual	JJ
cord-334133-61om170g	113	9	clade	clade	NN
cord-334133-61om170g	113	10	consensus	consensus	NN
cord-334133-61om170g	113	11	sequences	sequence	NNS
cord-334133-61om170g	113	12	of	of	IN
cord-334133-61om170g	113	13	700	700	CD
cord-334133-61om170g	113	14	I	I	NNP
cord-334133-61om170g	113	15	-	-	HYPH
cord-334133-61om170g	113	16	V	v	NN
cord-334133-61om170g	113	17	(	(	-LRB-
cord-334133-61om170g	113	18	clade	clade	NN
cord-334133-61om170g	113	19	B	B	NNP
cord-334133-61om170g	113	20	)	)	-RRB-
cord-334133-61om170g	113	21	,	,	.
cord-334133-61om170g	114	1	705	705	CD
cord-334133-61om170g	114	2	V	v	NN
cord-334133-61om170g	114	3	-	-	:
cord-334133-61om170g	114	4	I	i	NN
cord-334133-61om170g	114	5	(	(	-LRB-
cord-334133-61om170g	114	6	clade	clade	NN
cord-334133-61om170g	114	7	C	C	NNP
cord-334133-61om170g	114	8	)	)	-RRB-
cord-334133-61om170g	114	9	,	,	,
cord-334133-61om170g	114	10	711	711	CD
cord-334133-61om170g	114	11	I	I	NNP
cord-334133-61om170g	114	12	-	-	HYPH
cord-334133-61om170g	114	13	L	L	NNP
cord-334133-61om170g	114	14	(	(	-LRB-
cord-334133-61om170g	114	15	clade	clade	NN
cord-334133-61om170g	114	16	D	D	NNP
cord-334133-61om170g	114	17	)	)	-RRB-
cord-334133-61om170g	114	18	,	,	,
cord-334133-61om170g	114	19	and	and	CC
cord-334133-61om170g	114	20	712	712	CD
cord-334133-61om170g	114	21	V	v	NN
cord-334133-61om170g	114	22	-	-	:
cord-334133-61om170g	114	23	I	i	NN
cord-334133-61om170g	114	24	(	(	-LRB-
cord-334133-61om170g	114	25	clade	clade	NN
cord-334133-61om170g	114	26	A	a	NN
cord-334133-61om170g	114	27	)	)	-RRB-
cord-334133-61om170g	114	28	.	.	.
cord-334133-61om170g	115	1	The	the	DT
cord-334133-61om170g	115	2	region	region	NN
cord-334133-61om170g	115	3	767	767	CD
cord-334133-61om170g	115	4	RSLCLFSYHRLR	RSLCLFSYHRLR	NNP
cord-334133-61om170g	115	5	779	779	NNP
cord-334133-61om170g	115	6	containing	contain	VBG
cord-334133-61om170g	115	7	the	the	DT
cord-334133-61om170g	115	8	second	second	JJ
cord-334133-61om170g	115	9	potential	potential	JJ
cord-334133-61om170g	115	10	tyrosine	tyrosine	NN
cord-334133-61om170g	115	11	-	-	HYPH
cord-334133-61om170g	115	12	dependent	dependent	JJ
cord-334133-61om170g	115	13	sorting	sorting	NN
cord-334133-61om170g	115	14	signal	signal	NN
cord-334133-61om170g	115	15	(	(	-LRB-
cord-334133-61om170g	115	16	775	775	CD
cord-334133-61om170g	115	17	YHRL	YHRL	NNP
cord-334133-61om170g	115	18	778	778	CD
cord-334133-61om170g	115	19	)	)	-RRB-
cord-334133-61om170g	115	20	is	be	VBZ
cord-334133-61om170g	115	21	highly	highly	RB
cord-334133-61om170g	115	22	conserved	conserve	VBN
cord-334133-61om170g	115	23	.	.	.
cord-334133-61om170g	116	1	The	the	DT
cord-334133-61om170g	116	2	highly	highly	RB
cord-334133-61om170g	116	3	conserved	conserved	JJ
cord-334133-61om170g	116	4	790	790	CD
cord-334133-61om170g	116	5	ELLG	ELLG	NNP
cord-334133-61om170g	116	6	793	793	CD
cord-334133-61om170g	116	7	contains	contain	VBZ
cord-334133-61om170g	116	8	a	a	DT
cord-334133-61om170g	116	9	potential	potential	JJ
cord-334133-61om170g	116	10	di	di	FW
cord-334133-61om170g	116	11	-	-	HYPH
cord-334133-61om170g	116	12	leucine	leucine	NN
cord-334133-61om170g	116	13	signal	signal	NN
cord-334133-61om170g	116	14	,	,	,
cord-334133-61om170g	116	15	but	but	CC
cord-334133-61om170g	116	16	the	the	DT
cord-334133-61om170g	116	17	only	only	JJ
cord-334133-61om170g	116	18	di	di	NN
cord-334133-61om170g	116	19	-	-	HYPH
cord-334133-61om170g	116	20	leucine	leucine	NN
cord-334133-61om170g	116	21	signal	signal	NN
cord-334133-61om170g	116	22	known	know	VBN
cord-334133-61om170g	116	23	to	to	TO
cord-334133-61om170g	116	24	be	be	VB
cord-334133-61om170g	116	25	functional	functional	JJ
cord-334133-61om170g	116	26	in	in	IN
cord-334133-61om170g	116	27	gp41	gp41	NNP
cord-334133-61om170g	116	28	is	be	VBZ
cord-334133-61om170g	116	29	862	862	CD
cord-334133-61om170g	116	30	LL	LL	NNP
cord-334133-61om170g	116	31	863	863	CD
cord-334133-61om170g	117	1	(	(	-LRB-
cord-334133-61om170g	117	2	Wyss	Wyss	NNP
cord-334133-61om170g	117	3	et	et	NNP
cord-334133-61om170g	117	4	al	al	NNP
cord-334133-61om170g	117	5	.	.	NNP
cord-334133-61om170g	117	6	,	,	,
cord-334133-61om170g	117	7	2001	2001	CD
cord-334133-61om170g	117	8	)	)	-RRB-
cord-334133-61om170g	117	9	.	.	.
cord-334133-61om170g	118	1	The	the	DT
cord-334133-61om170g	118	2	Kennedy	Kennedy	NNP
cord-334133-61om170g	118	3	sequence	sequence	NN
cord-334133-61om170g	118	4	(	(	-LRB-
cord-334133-61om170g	118	5	731	731	CD
cord-334133-61om170g	118	6	PRGPDRPGRIEEEG	PRGPDRPGRIEEEG	NNP
cord-334133-61om170g	118	7	-	-	HYPH
cord-334133-61om170g	118	8	GEQDRDRS	GEQDRDRS	NNP
cord-334133-61om170g	118	9	752	752	CD
cord-334133-61om170g	118	10	)	)	-RRB-
cord-334133-61om170g	118	11	in	in	IN
cord-334133-61om170g	118	12	clade	clade	NN
cord-334133-61om170g	118	13	B	b	NN
cord-334133-61om170g	118	14	viruses	virus	NNS
cord-334133-61om170g	118	15	contains	contain	VBZ
cord-334133-61om170g	118	16	the	the	DT
cord-334133-61om170g	118	17	neutralizing	neutralize	VBG
cord-334133-61om170g	118	18	epitope	epitope	NN
cord-334133-61om170g	118	19	core	core	NN
cord-334133-61om170g	118	20	sequence	sequence	NN
cord-334133-61om170g	118	21	746	746	CD
cord-334133-61om170g	118	22	ERDRD	ERDRD	NNP
cord-334133-61om170g	118	23	750	750	CD
cord-334133-61om170g	118	24	,	,	,
cord-334133-61om170g	118	25	and	and	CC
cord-334133-61om170g	118	26	two	two	CD
cord-334133-61om170g	118	27	non	non	JJ
cord-334133-61om170g	118	28	-	-	JJ
cord-334133-61om170g	118	29	neutralizing	neutralizing	JJ
cord-334133-61om170g	118	30	epitopes	epitope	NNS
cord-334133-61om170g	118	31	(	(	-LRB-
cord-334133-61om170g	118	32	734	734	CD
cord-334133-61om170g	118	33	PDRPEG	PDRPEG	NNP
cord-334133-61om170g	118	34	739	739	CD
cord-334133-61om170g	118	35	and	and	CC
cord-334133-61om170g	118	36	740	740	CD
cord-334133-61om170g	118	37	IEEE	IEEE	NNP
cord-334133-61om170g	118	38	743	743	CD
cord-334133-61om170g	118	39	)	)	-RRB-
cord-334133-61om170g	119	1	(	(	-LRB-
cord-334133-61om170g	119	2	Chanh	Chanh	NNP
cord-334133-61om170g	119	3	et	et	NNP
cord-334133-61om170g	119	4	al	al	NNP
cord-334133-61om170g	119	5	.	.	.
cord-334133-61om170g	120	1	,	,	,
cord-334133-61om170g	120	2	1986	1986	CD
cord-334133-61om170g	120	3	;	;	:
cord-334133-61om170g	120	4	Dalgleish	Dalgleish	NNP
cord-334133-61om170g	120	5	et	et	FW
cord-334133-61om170g	120	6	al	al	NNP
cord-334133-61om170g	120	7	.	.	NNP
cord-334133-61om170g	120	8	,	,	,
cord-334133-61om170g	120	9	1988	1988	CD
cord-334133-61om170g	120	10	;	;	:
cord-334133-61om170g	120	11	Evans	Evans	NNP
cord-334133-61om170g	120	12	et	et	NNP
cord-334133-61om170g	120	13	al	al	NNP
cord-334133-61om170g	120	14	.	.	NNP
cord-334133-61om170g	120	15	,	,	,
cord-334133-61om170g	120	16	1989	1989	CD
cord-334133-61om170g	120	17	;	;	:
cord-334133-61om170g	121	1	Ho	Ho	NNP
cord-334133-61om170g	121	2	et	et	FW
cord-334133-61om170g	121	3	al	al	NNP
cord-334133-61om170g	121	4	.	.	NNP
cord-334133-61om170g	121	5	,	,	,
cord-334133-61om170g	121	6	1987	1987	CD
cord-334133-61om170g	121	7	;	;	:
cord-334133-61om170g	121	8	Kennedy	Kennedy	NNP
cord-334133-61om170g	121	9	et	et	NNP
cord-334133-61om170g	121	10	al	al	NNP
cord-334133-61om170g	121	11	.	.	NNP
cord-334133-61om170g	121	12	,	,	,
cord-334133-61om170g	121	13	1986	1986	CD
cord-334133-61om170g	121	14	;	;	:
cord-334133-61om170g	121	15	Niedrig	Niedrig	NNP
cord-334133-61om170g	121	16	et	et	NNP
cord-334133-61om170g	121	17	al	al	NNP
cord-334133-61om170g	121	18	.	.	.
cord-334133-61om170g	122	1	,	,	,
cord-334133-61om170g	122	2	1992	1992	CD
cord-334133-61om170g	122	3	;	;	:
cord-334133-61om170g	122	4	Vella	Vella	NNP
cord-334133-61om170g	122	5	et	et	NNP
cord-334133-61om170g	122	6	al	al	NNP
cord-334133-61om170g	122	7	.	.	NNP
cord-334133-61om170g	122	8	,	,	,
cord-334133-61om170g	122	9	1993	1993	CD
cord-334133-61om170g	122	10	)	)	-RRB-
cord-334133-61om170g	122	11	.	.	.
cord-334133-61om170g	123	1	Overall	overall	RB
cord-334133-61om170g	123	2	the	the	DT
cord-334133-61om170g	123	3	Kennedy	Kennedy	NNP
cord-334133-61om170g	123	4	sequence	sequence	NN
cord-334133-61om170g	123	5	is	be	VBZ
cord-334133-61om170g	123	6	only	only	RB
cord-334133-61om170g	123	7	poorly	poorly	RB
cord-334133-61om170g	123	8	to	to	IN
cord-334133-61om170g	123	9	moderately	moderately	RB
cord-334133-61om170g	123	10	conserved	conserve	VBN
cord-334133-61om170g	123	11	.	.	.
cord-334133-61om170g	124	1	Specifically	specifically	RB
cord-334133-61om170g	124	2	731	731	CD
cord-334133-61om170g	124	3	PRGPDRPGRI	PRGPDRPGRI	NNP
cord-334133-61om170g	124	4	740	740	CD
cord-334133-61om170g	124	5	and	and	CC
cord-334133-61om170g	124	6	747	747	CD
cord-334133-61om170g	124	7	QDRDRS	QDRDRS	NNP
cord-334133-61om170g	124	8	752	752	CD
cord-334133-61om170g	124	9	are	be	VBP
cord-334133-61om170g	124	10	poorly	poorly	RB
cord-334133-61om170g	124	11	to	to	IN
cord-334133-61om170g	124	12	moderately	moderately	RB
cord-334133-61om170g	124	13	conserved	conserve	VBN
cord-334133-61om170g	124	14	,	,	,
cord-334133-61om170g	124	15	but	but	CC
cord-334133-61om170g	124	16	741	741	CD
cord-334133-61om170g	124	17	EEEGGE	EEEGGE	NNP
cord-334133-61om170g	124	18	746	746	NNP
cord-334133-61om170g	124	19	is	be	VBZ
cord-334133-61om170g	124	20	moderately	moderately	RB
cord-334133-61om170g	124	21	to	to	IN
cord-334133-61om170g	124	22	highly	highly	RB
cord-334133-61om170g	124	23	conserved	conserve	VBN
cord-334133-61om170g	124	24	.	.	.
cord-334133-61om170g	125	1	741	741	CD
cord-334133-61om170g	125	2	EEEGGE	EEEGGE	NNP
cord-334133-61om170g	125	3	746	746	NNP
cord-334133-61om170g	125	4	is	be	VBZ
cord-334133-61om170g	125	5	notable	notable	JJ
cord-334133-61om170g	125	6	in	in	IN
cord-334133-61om170g	125	7	having	have	VBG
cord-334133-61om170g	125	8	67	67	CD
cord-334133-61om170g	125	9	%	%	NN
cord-334133-61om170g	125	10	acidic	acidic	JJ
cord-334133-61om170g	125	11	residues	residue	NNS
cord-334133-61om170g	125	12	.	.	.
cord-334133-61om170g	126	1	746	746	CD
cord-334133-61om170g	126	2	ERDRD	ERDRD	NNP
cord-334133-61om170g	126	3	750	750	CD
cord-334133-61om170g	126	4	is	be	VBZ
cord-334133-61om170g	126	5	present	present	JJ
cord-334133-61om170g	126	6	only	only	RB
cord-334133-61om170g	126	7	in	in	IN
cord-334133-61om170g	126	8	clade	clade	NN
cord-334133-61om170g	126	9	B	b	NN
cord-334133-61om170g	126	10	and	and	CC
cord-334133-61om170g	126	11	the	the	DT
cord-334133-61om170g	126	12	recombinant	recombinant	JJ
cord-334133-61om170g	126	13	CRF03	CRF03	NNP
cord-334133-61om170g	126	14	_	_	NN
cord-334133-61om170g	126	15	AB	ab	NN
cord-334133-61om170g	126	16	clade	clade	NN
cord-334133-61om170g	126	17	.	.	.
cord-334133-61om170g	127	1	Clades	Clades	NNP
cord-334133-61om170g	127	2	A	A	NNP
cord-334133-61om170g	127	3	and	and	CC
cord-334133-61om170g	127	4	C	C	NNP
cord-334133-61om170g	127	5	have	have	VBP
cord-334133-61om170g	127	6	746	746	CD
cord-334133-61om170g	127	7	EQDRD	EQDRD	NNP
cord-334133-61om170g	127	8	750	750	CD
cord-334133-61om170g	127	9	and	and	CC
cord-334133-61om170g	127	10	clade	clade	NN
cord-334133-61om170g	127	11	D	D	NNP
cord-334133-61om170g	127	12	has	have	VBZ
cord-334133-61om170g	127	13	746	746	CD
cord-334133-61om170g	127	14	EQGRG	EQGRG	NNP
cord-334133-61om170g	127	15	750	750	CD
cord-334133-61om170g	127	16	.	.	.
cord-334133-61om170g	128	1	The	the	DT
cord-334133-61om170g	128	2	exchange	exchange	NN
cord-334133-61om170g	128	3	of	of	IN
cord-334133-61om170g	128	4	747	747	CD
cord-334133-61om170g	128	5	R	r	NN
cord-334133-61om170g	128	6	(	(	-LRB-
cord-334133-61om170g	128	7	basic	basic	JJ
cord-334133-61om170g	128	8	,	,	,
cord-334133-61om170g	128	9	ionizable	ionizable	JJ
cord-334133-61om170g	128	10	,	,	,
cord-334133-61om170g	128	11	hydrophilic	hydrophilic	JJ
cord-334133-61om170g	128	12	,	,	,
cord-334133-61om170g	128	13	with	with	IN
cord-334133-61om170g	128	14	a	a	DT
cord-334133-61om170g	128	15	long	long	JJ
cord-334133-61om170g	128	16	side	side	NN
cord-334133-61om170g	128	17	chain	chain	NN
cord-334133-61om170g	128	18	)	)	-RRB-
cord-334133-61om170g	128	19	for	for	IN
cord-334133-61om170g	128	20	Q	Q	NNP
cord-334133-61om170g	128	21	(	(	-LRB-
cord-334133-61om170g	128	22	polar	polar	JJ
cord-334133-61om170g	128	23	,	,	,
cord-334133-61om170g	128	24	hydrophilic	hydrophilic	JJ
cord-334133-61om170g	128	25	,	,	,
cord-334133-61om170g	128	26	amidic	amidic	UH
cord-334133-61om170g	128	27	,	,	,
cord-334133-61om170g	128	28	with	with	IN
cord-334133-61om170g	128	29	a	a	DT
cord-334133-61om170g	128	30	shorter	short	JJR
cord-334133-61om170g	128	31	side	side	NN
cord-334133-61om170g	128	32	chain	chain	NN
cord-334133-61om170g	128	33	)	)	-RRB-
cord-334133-61om170g	128	34	might	may	MD
cord-334133-61om170g	128	35	create	create	VB
cord-334133-61om170g	128	36	a	a	DT
cord-334133-61om170g	128	37	different	different	JJ
cord-334133-61om170g	128	38	epitope	epitope	NN
cord-334133-61om170g	128	39	,	,	,
cord-334133-61om170g	128	40	and	and	CC
cord-334133-61om170g	128	41	746	746	CD
cord-334133-61om170g	128	42	ERDRD	ERDRD	NNP
cord-334133-61om170g	128	43	750	750	CD
cord-334133-61om170g	128	44	-specific	-specific	JJ
cord-334133-61om170g	128	45	neutralizing	neutralize	VBG
cord-334133-61om170g	128	46	antibody	antibody	NN
cord-334133-61om170g	128	47	may	may	MD
cord-334133-61om170g	128	48	not	not	RB
cord-334133-61om170g	128	49	recognize	recognize	VB
cord-334133-61om170g	128	50	746	746	CD
cord-334133-61om170g	128	51	EQDRD	EQDRD	NNP
cord-334133-61om170g	128	52	750	750	CD
cord-334133-61om170g	128	53	.	.	.
cord-334133-61om170g	129	1	The	the	DT
cord-334133-61om170g	129	2	gp41	gp41	NNP
cord-334133-61om170g	129	3	tail	tail	NN
cord-334133-61om170g	129	4	reading	reading	NN
cord-334133-61om170g	129	5	frame	frame	NN
cord-334133-61om170g	129	6	overlaps	overlap	VBZ
cord-334133-61om170g	129	7	the	the	DT
cord-334133-61om170g	129	8	second	second	JJ
cord-334133-61om170g	129	9	exons	exon	NNS
cord-334133-61om170g	129	10	of	of	IN
cord-334133-61om170g	129	11	tat	tat	NN
cord-334133-61om170g	129	12	(	(	-LRB-
cord-334133-61om170g	129	13	+1	+1	NFP
cord-334133-61om170g	129	14	relative	relative	NN
cord-334133-61om170g	129	15	to	to	IN
cord-334133-61om170g	129	16	env	env	NN
cord-334133-61om170g	129	17	)	)	-RRB-
cord-334133-61om170g	129	18	and	and	CC
cord-334133-61om170g	129	19	rev	rev	NNP
cord-334133-61om170g	129	20	(	(	-LRB-
cord-334133-61om170g	129	21	+2	+2	NNP
cord-334133-61om170g	129	22	)	)	-RRB-
cord-334133-61om170g	129	23	.	.	.
cord-334133-61om170g	130	1	Both	both	DT
cord-334133-61om170g	130	2	of	of	IN
cord-334133-61om170g	130	3	the	the	DT
cord-334133-61om170g	130	4	latter	latter	JJ
cord-334133-61om170g	130	5	start	start	NN
cord-334133-61om170g	130	6	Fig	Fig	NNP
cord-334133-61om170g	130	7	.	.	.
cord-334133-61om170g	131	1	1	1	LS
cord-334133-61om170g	131	2	.	.	.
cord-334133-61om170g	132	1	Summary	summary	NN
cord-334133-61om170g	132	2	of	of	IN
cord-334133-61om170g	132	3	the	the	DT
cord-334133-61om170g	132	4	conservation	conservation	NN
cord-334133-61om170g	132	5	of	of	IN
cord-334133-61om170g	132	6	gp41	gp41	NNP
cord-334133-61om170g	132	7	C	c	NN
cord-334133-61om170g	132	8	-	-	HYPH
cord-334133-61om170g	132	9	terminal	terminal	NN
cord-334133-61om170g	132	10	amino	amino	NN
cord-334133-61om170g	132	11	acid	acid	NN
cord-334133-61om170g	132	12	residues	residue	NNS
cord-334133-61om170g	133	1	690	690	CD
cord-334133-61om170g	134	1	-793	-793	NNP
cord-334133-61om170g	134	2	of	of	IN
cord-334133-61om170g	135	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	135	2	clades	clade	NNS
cord-334133-61om170g	135	3	A	a	DT
cord-334133-61om170g	135	4	to	to	IN
cord-334133-61om170g	135	5	D	D	NNP
cord-334133-61om170g	135	6	,	,	,
cord-334133-61om170g	135	7	using	use	VBG
cord-334133-61om170g	135	8	a	a	DT
cord-334133-61om170g	135	9	7-residue	7-residue	CD
cord-334133-61om170g	135	10	moving	move	VBG
cord-334133-61om170g	135	11	window	window	NN
cord-334133-61om170g	135	12	.	.	.
cord-334133-61om170g	136	1	at	at	IN
cord-334133-61om170g	136	2	the	the	DT
cord-334133-61om170g	136	3	same	same	JJ
cord-334133-61om170g	136	4	position	position	NN
cord-334133-61om170g	136	5	,	,	,
cord-334133-61om170g	136	6	equivalent	equivalent	JJ
cord-334133-61om170g	136	7	to	to	IN
cord-334133-61om170g	136	8	the	the	DT
cord-334133-61om170g	136	9	codon	codon	NN
cord-334133-61om170g	136	10	for	for	IN
cord-334133-61om170g	136	11	residue	residue	NN
cord-334133-61om170g	136	12	725	725	CD
cord-334133-61om170g	136	13	of	of	IN
cord-334133-61om170g	136	14	Env	Env	NNP
cord-334133-61om170g	136	15	.	.	.
cord-334133-61om170g	137	1	Tat	Tat	NNP
cord-334133-61om170g	137	2	and	and	CC
cord-334133-61om170g	137	3	Rev	Rev	NNP
cord-334133-61om170g	137	4	stop	stop	VB
cord-334133-61om170g	137	5	at	at	IN
cord-334133-61om170g	137	6	the	the	DT
cord-334133-61om170g	137	7	equivalent	equivalent	NN
cord-334133-61om170g	137	8	of	of	IN
cord-334133-61om170g	137	9	the	the	DT
cord-334133-61om170g	137	10	codons	codon	NNS
cord-334133-61om170g	137	11	for	for	IN
cord-334133-61om170g	137	12	residues	residue	NNS
cord-334133-61om170g	137	13	740	740	CD
cord-334133-61om170g	137	14	and	and	CC
cord-334133-61om170g	137	15	816	816	CD
cord-334133-61om170g	137	16	of	of	IN
cord-334133-61om170g	137	17	Env	Env	NNP
cord-334133-61om170g	137	18	,	,	,
cord-334133-61om170g	137	19	respectively	respectively	RB
cord-334133-61om170g	137	20	.	.	.
cord-334133-61om170g	138	1	This	this	DT
cord-334133-61om170g	138	2	is	be	VBZ
cord-334133-61om170g	138	3	the	the	DT
cord-334133-61om170g	138	4	only	only	JJ
cord-334133-61om170g	138	5	part	part	NN
cord-334133-61om170g	138	6	of	of	IN
cord-334133-61om170g	138	7	the	the	DT
cord-334133-61om170g	138	8	env	env	NN
cord-334133-61om170g	138	9	sequence	sequence	NN
cord-334133-61om170g	138	10	where	where	WRB
cord-334133-61om170g	138	11	all	all	DT
cord-334133-61om170g	138	12	three	three	CD
cord-334133-61om170g	138	13	ORFs	orf	NNS
cord-334133-61om170g	138	14	are	be	VBP
cord-334133-61om170g	138	15	used	use	VBN
cord-334133-61om170g	138	16	,	,	,
cord-334133-61om170g	138	17	yet	yet	CC
cord-334133-61om170g	138	18	counter	counter	RB
cord-334133-61om170g	138	19	-	-	VBZ
cord-334133-61om170g	138	20	intuitively	intuitively	RB
cord-334133-61om170g	138	21	,	,	,
cord-334133-61om170g	138	22	conservation	conservation	NN
cord-334133-61om170g	138	23	of	of	IN
cord-334133-61om170g	138	24	725	725	CD
cord-334133-61om170g	138	25	-740	-740	NN
cord-334133-61om170g	138	26	of	of	IN
cord-334133-61om170g	138	27	Env	Env	NNP
cord-334133-61om170g	138	28	ranges	range	NNS
cord-334133-61om170g	138	29	from	from	IN
cord-334133-61om170g	138	30	poor	poor	JJ
cord-334133-61om170g	138	31	to	to	IN
cord-334133-61om170g	138	32	high	high	JJ
cord-334133-61om170g	138	33	.	.	.
cord-334133-61om170g	139	1	It	-PRON-	PRP
cord-334133-61om170g	139	2	may	may	MD
cord-334133-61om170g	139	3	be	be	VB
cord-334133-61om170g	139	4	that	that	IN
cord-334133-61om170g	139	5	the	the	DT
cord-334133-61om170g	139	6	tat	tat	NN
cord-334133-61om170g	140	1	and/or	and/or	CC
cord-334133-61om170g	140	2	rev	rev	NNP
cord-334133-61om170g	140	3	sequences	sequence	NNS
cord-334133-61om170g	140	4	are	be	VBP
cord-334133-61om170g	140	5	conserved	conserve	VBN
cord-334133-61om170g	140	6	at	at	IN
cord-334133-61om170g	140	7	the	the	DT
cord-334133-61om170g	140	8	expense	expense	NN
cord-334133-61om170g	140	9	of	of	IN
cord-334133-61om170g	140	10	env	env	NN
cord-334133-61om170g	140	11	.	.	.
cord-334133-61om170g	141	1	All	all	DT
cord-334133-61om170g	141	2	clades	clade	NNS
cord-334133-61om170g	141	3	have	have	VBP
cord-334133-61om170g	141	4	a	a	DT
cord-334133-61om170g	141	5	very	very	RB
cord-334133-61om170g	141	6	highly	highly	RB
cord-334133-61om170g	141	7	conserved	conserve	VBN
cord-334133-61om170g	141	8	745	745	CD
cord-334133-61om170g	141	9	G	g	NN
cord-334133-61om170g	141	10	(	(	-LRB-
cord-334133-61om170g	141	11	100	100	CD
cord-334133-61om170g	141	12	%	%	NN
cord-334133-61om170g	141	13	)	)	-RRB-
cord-334133-61om170g	141	14	,	,	,
cord-334133-61om170g	141	15	758	758	CD
cord-334133-61om170g	141	16	G	g	NN
cord-334133-61om170g	141	17	(	(	-LRB-
cord-334133-61om170g	141	18	99.9	99.9	CD
cord-334133-61om170g	141	19	%	%	NN
cord-334133-61om170g	141	20	)	)	-RRB-
cord-334133-61om170g	141	21	,	,	,
cord-334133-61om170g	141	22	and	and	CC
cord-334133-61om170g	141	23	764	764	CD
cord-334133-61om170g	141	24	W	w	NN
cord-334133-61om170g	141	25	(	(	-LRB-
cord-334133-61om170g	141	26	99.4	99.4	CD
cord-334133-61om170g	141	27	%	%	NN
cord-334133-61om170g	141	28	)	)	-RRB-
cord-334133-61om170g	141	29	.	.	.
cord-334133-61om170g	142	1	The	the	DT
cord-334133-61om170g	142	2	conservation	conservation	NN
cord-334133-61om170g	142	3	of	of	IN
cord-334133-61om170g	142	4	745	745	CD
cord-334133-61om170g	142	5	G	g	NN
cord-334133-61om170g	142	6	and	and	CC
cord-334133-61om170g	142	7	758	758	CD
cord-334133-61om170g	142	8	G	g	NN
cord-334133-61om170g	142	9	may	may	MD
cord-334133-61om170g	142	10	be	be	VB
cord-334133-61om170g	142	11	a	a	DT
cord-334133-61om170g	142	12	consequence	consequence	NN
cord-334133-61om170g	142	13	of	of	IN
cord-334133-61om170g	142	14	the	the	DT
cord-334133-61om170g	142	15	reading	reading	NN
cord-334133-61om170g	142	16	frame	frame	NN
cord-334133-61om170g	142	17	shared	share	VBN
cord-334133-61om170g	142	18	with	with	IN
cord-334133-61om170g	142	19	Rev.	Rev.	NNP
cord-334133-61om170g	143	1	The	the	DT
cord-334133-61om170g	143	2	last	last	JJ
cord-334133-61om170g	143	3	two	two	CD
cord-334133-61om170g	143	4	bases	basis	NNS
cord-334133-61om170g	143	5	of	of	IN
cord-334133-61om170g	143	6	a	a	DT
cord-334133-61om170g	143	7	rev	rev	NNP
cord-334133-61om170g	143	8	codon	codon	NN
cord-334133-61om170g	143	9	are	be	VBP
cord-334133-61om170g	143	10	the	the	DT
cord-334133-61om170g	143	11	first	first	JJ
cord-334133-61om170g	143	12	two	two	CD
cord-334133-61om170g	143	13	bases	basis	NNS
cord-334133-61om170g	143	14	of	of	IN
cord-334133-61om170g	143	15	the	the	DT
cord-334133-61om170g	143	16	env	env	NN
cord-334133-61om170g	143	17	codon	codon	NN
cord-334133-61om170g	143	18	.	.	.
cord-334133-61om170g	144	1	Thus	thus	RB
cord-334133-61om170g	144	2	,	,	,
cord-334133-61om170g	144	3	if	if	IN
cord-334133-61om170g	144	4	rev	rev	NNP
cord-334133-61om170g	144	5	requires	require	VBZ
cord-334133-61om170g	144	6	a	a	DT
cord-334133-61om170g	144	7	tryptophan	tryptophan	NN
cord-334133-61om170g	144	8	in	in	IN
cord-334133-61om170g	144	9	its	-PRON-	PRP$
cord-334133-61om170g	144	10	second	second	JJ
cord-334133-61om170g	144	11	exon	exon	NN
cord-334133-61om170g	144	12	,	,	,
cord-334133-61om170g	144	13	the	the	DT
cord-334133-61om170g	144	14	overlapping	overlap	VBG
cord-334133-61om170g	144	15	codon	codon	NN
cord-334133-61om170g	144	16	of	of	IN
cord-334133-61om170g	144	17	env	env	NN
cord-334133-61om170g	144	18	has	have	VBZ
cord-334133-61om170g	144	19	to	to	TO
cord-334133-61om170g	144	20	be	be	VB
cord-334133-61om170g	144	21	glycine	glycine	NN
cord-334133-61om170g	144	22	,	,	,
cord-334133-61om170g	144	23	since	since	IN
cord-334133-61om170g	144	24	tryptophan	tryptophan	NN
cord-334133-61om170g	144	25	is	be	VBZ
cord-334133-61om170g	144	26	only	only	RB
cord-334133-61om170g	144	27	encoded	encode	VBN
cord-334133-61om170g	144	28	by	by	IN
cord-334133-61om170g	144	29	UGG	UGG	NNP
cord-334133-61om170g	144	30	,	,	,
cord-334133-61om170g	144	31	while	while	IN
cord-334133-61om170g	144	32	the	the	DT
cord-334133-61om170g	144	33	codon	codon	NN
cord-334133-61om170g	144	34	for	for	IN
cord-334133-61om170g	144	35	glycine	glycine	NN
cord-334133-61om170g	144	36	is	be	VBZ
cord-334133-61om170g	144	37	GGx	GGx	NNS
cord-334133-61om170g	144	38	.	.	.
cord-334133-61om170g	145	1	The	the	DT
cord-334133-61om170g	145	2	reason	reason	NN
cord-334133-61om170g	145	3	why	why	WRB
cord-334133-61om170g	145	4	764	764	CD
cord-334133-61om170g	145	5	W	W	NNP
cord-334133-61om170g	145	6	is	be	VBZ
cord-334133-61om170g	145	7	very	very	RB
cord-334133-61om170g	145	8	highly	highly	RB
cord-334133-61om170g	145	9	conserved	conserved	JJ
cord-334133-61om170g	145	10	is	be	VBZ
cord-334133-61om170g	145	11	not	not	RB
cord-334133-61om170g	145	12	clear	clear	JJ
cord-334133-61om170g	145	13	,	,	,
cord-334133-61om170g	145	14	but	but	CC
cord-334133-61om170g	145	15	any	any	DT
cord-334133-61om170g	145	16	change	change	NN
cord-334133-61om170g	145	17	in	in	IN
cord-334133-61om170g	145	18	its	-PRON-	PRP$
cord-334133-61om170g	145	19	codon	codon	NN
cord-334133-61om170g	145	20	results	result	NNS
cord-334133-61om170g	145	21	in	in	IN
cord-334133-61om170g	145	22	a	a	DT
cord-334133-61om170g	145	23	different	different	JJ
cord-334133-61om170g	145	24	amino	amino	NN
cord-334133-61om170g	145	25	acid	acid	NN
cord-334133-61om170g	145	26	residue	residue	NN
cord-334133-61om170g	145	27	or	or	CC
cord-334133-61om170g	145	28	a	a	DT
cord-334133-61om170g	145	29	stop	stop	NN
cord-334133-61om170g	145	30	codon	codon	NN
cord-334133-61om170g	145	31	(	(	-LRB-
cord-334133-61om170g	145	32	UGA	UGA	NNP
cord-334133-61om170g	145	33	or	or	CC
cord-334133-61om170g	145	34	UAG	UAG	NNP
cord-334133-61om170g	145	35	)	)	-RRB-
cord-334133-61om170g	145	36	.	.	.
cord-334133-61om170g	146	1	Regions	region	NNS
cord-334133-61om170g	146	2	of	of	IN
cord-334133-61om170g	146	3	conservation	conservation	NN
cord-334133-61om170g	146	4	for	for	IN
cord-334133-61om170g	146	5	clades	clade	NNS
cord-334133-61om170g	147	1	A	a	DT
cord-334133-61om170g	147	2	to	to	IN
cord-334133-61om170g	147	3	D	d	NN
cord-334133-61om170g	147	4	consensus	consensus	NN
cord-334133-61om170g	147	5	sequences	sequence	NNS
cord-334133-61om170g	147	6	of	of	IN
cord-334133-61om170g	147	7	gp41	gp41	NNP
cord-334133-61om170g	147	8	residues	residue	NNS
cord-334133-61om170g	147	9	690	690	CD
cord-334133-61om170g	147	10	-793	-793	NN
cord-334133-61om170g	147	11	,	,	,
cord-334133-61om170g	147	12	and	and	CC
cord-334133-61om170g	147	13	an	an	DT
cord-334133-61om170g	147	14	overall	overall	JJ
cord-334133-61om170g	147	15	consensus	consensus	NN
cord-334133-61om170g	147	16	sequence	sequence	NN
cord-334133-61om170g	147	17	are	be	VBP
cord-334133-61om170g	147	18	summarized	summarize	VBN
cord-334133-61om170g	147	19	in	in	IN
cord-334133-61om170g	147	20	Fig	Fig	NNP
cord-334133-61om170g	147	21	.	.	.
cord-334133-61om170g	148	1	2	2	LS
cord-334133-61om170g	148	2	.	.	.
cord-334133-61om170g	149	1	The	the	DT
cord-334133-61om170g	149	2	consensus	consensus	NN
cord-334133-61om170g	149	3	sequences	sequence	NNS
cord-334133-61om170g	149	4	of	of	IN
cord-334133-61om170g	150	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	150	2	clades	clade	NNS
cord-334133-61om170g	150	3	A	a	DT
cord-334133-61om170g	150	4	to	to	IN
cord-334133-61om170g	150	5	D	d	NN
cord-334133-61om170g	150	6	derived	derive	VBN
cord-334133-61om170g	150	7	above	above	RB
cord-334133-61om170g	150	8	were	be	VBD
cord-334133-61om170g	150	9	analyzed	analyze	VBN
cord-334133-61om170g	150	10	individually	individually	RB
cord-334133-61om170g	150	11	(	(	-LRB-
cord-334133-61om170g	150	12	see	see	VB
cord-334133-61om170g	150	13	Materials	material	NNS
cord-334133-61om170g	150	14	and	and	CC
cord-334133-61om170g	150	15	methods	method	NNS
cord-334133-61om170g	150	16	)	)	-RRB-
cord-334133-61om170g	150	17	,	,	,
cord-334133-61om170g	150	18	but	but	CC
cord-334133-61om170g	150	19	as	as	IN
cord-334133-61om170g	150	20	the	the	DT
cord-334133-61om170g	150	21	predicted	predict	VBN
cord-334133-61om170g	150	22	structures	structure	NNS
cord-334133-61om170g	150	23	were	be	VBD
cord-334133-61om170g	150	24	virtually	virtually	RB
cord-334133-61om170g	150	25	identical	identical	JJ
cord-334133-61om170g	150	26	,	,	,
cord-334133-61om170g	150	27	only	only	RB
cord-334133-61om170g	150	28	clade	clade	NN
cord-334133-61om170g	150	29	A	a	DT
cord-334133-61om170g	150	30	data	datum	NNS
cord-334133-61om170g	150	31	are	be	VBP
cord-334133-61om170g	150	32	presented	present	VBN
cord-334133-61om170g	150	33	.	.	.
cord-334133-61om170g	151	1	According	accord	VBG
cord-334133-61om170g	151	2	to	to	IN
cord-334133-61om170g	151	3	Kyte	Kyte	NNP
cord-334133-61om170g	151	4	and	and	CC
cord-334133-61om170g	151	5	Doolittle	Doolittle	NNP
cord-334133-61om170g	151	6	(	(	-LRB-
cord-334133-61om170g	151	7	1982	1982	CD
cord-334133-61om170g	151	8	)	)	-RRB-
cord-334133-61om170g	151	9	,	,	,
cord-334133-61om170g	151	10	four	four	CD
cord-334133-61om170g	151	11	regions	region	NNS
cord-334133-61om170g	151	12	(	(	-LRB-
cord-334133-61om170g	151	13	690	690	CD
cord-334133-61om170g	151	14	-699	-699	NN
cord-334133-61om170g	151	15	,	,	,
cord-334133-61om170g	151	16	702	702	CD
cord-334133-61om170g	151	17	-	-	HYPH
cord-334133-61om170g	151	18	711	711	CD
cord-334133-61om170g	151	19	,	,	,
cord-334133-61om170g	151	20	758	758	CD
cord-334133-61om170g	151	21	-763	-763	NN
cord-334133-61om170g	151	22	,	,	,
cord-334133-61om170g	151	23	and	and	CC
cord-334133-61om170g	151	24	783	783	CD
cord-334133-61om170g	151	25	-	-	HYPH
cord-334133-61om170g	151	26	787	787	CD
cord-334133-61om170g	151	27	)	)	-RRB-
cord-334133-61om170g	151	28	have	have	VBP
cord-334133-61om170g	151	29	hydropathy	hydropathy	JJ
cord-334133-61om170g	151	30	values	value	NNS
cord-334133-61om170g	151	31	of	of	IN
cord-334133-61om170g	151	32	>	>	$
cord-334133-61om170g	151	33	1.6	1.6	CD
cord-334133-61om170g	151	34	,	,	,
cord-334133-61om170g	151	35	indicating	indicate	VBG
cord-334133-61om170g	151	36	that	that	IN
cord-334133-61om170g	151	37	they	-PRON-	PRP
cord-334133-61om170g	151	38	are	be	VBP
cord-334133-61om170g	151	39	potential	potential	JJ
cord-334133-61om170g	151	40	MSDs	msd	NNS
cord-334133-61om170g	151	41	(	(	-LRB-
cord-334133-61om170g	151	42	Fig	Fig	NNP
cord-334133-61om170g	151	43	.	.	.
cord-334133-61om170g	151	44	3a	3a	NNP
cord-334133-61om170g	151	45	)	)	-RRB-
cord-334133-61om170g	151	46	.	.	.
cord-334133-61om170g	152	1	There	there	EX
cord-334133-61om170g	152	2	are	be	VBP
cord-334133-61om170g	152	3	two	two	CD
cord-334133-61om170g	152	4	single	single	JJ
cord-334133-61om170g	152	5	point	point	NN
cord-334133-61om170g	152	6	peaks	peak	NNS
cord-334133-61om170g	152	7	of	of	IN
cord-334133-61om170g	152	8	1.6	1.6	CD
cord-334133-61om170g	152	9	at	at	IN
cord-334133-61om170g	152	10	residues	residue	NNS
cord-334133-61om170g	152	11	771	771	CD
cord-334133-61om170g	152	12	and	and	CC
cord-334133-61om170g	152	13	781	781	CD
cord-334133-61om170g	152	14	,	,	,
cord-334133-61om170g	152	15	but	but	CC
cord-334133-61om170g	152	16	the	the	DT
cord-334133-61om170g	152	17	values	value	NNS
cord-334133-61om170g	152	18	of	of	IN
cord-334133-61om170g	152	19	surrounding	surround	VBG
cord-334133-61om170g	152	20	residues	residue	NNS
cord-334133-61om170g	152	21	are	be	VBP
cord-334133-61om170g	152	22	too	too	RB
cord-334133-61om170g	152	23	low	low	JJ
cord-334133-61om170g	152	24	for	for	IN
cord-334133-61om170g	152	25	these	these	DT
cord-334133-61om170g	152	26	to	to	TO
cord-334133-61om170g	152	27	form	form	VB
cord-334133-61om170g	152	28	an	an	DT
cord-334133-61om170g	152	29	MSD	msd	NN
cord-334133-61om170g	152	30	.	.	.
cord-334133-61om170g	153	1	The	the	DT
cord-334133-61om170g	153	2	Kennedy	Kennedy	NNP
cord-334133-61om170g	153	3	region	region	NN
cord-334133-61om170g	153	4	(	(	-LRB-
cord-334133-61om170g	153	5	731	731	CD
cord-334133-61om170g	153	6	-752	-752	NNS
cord-334133-61om170g	153	7	)	)	-RRB-
cord-334133-61om170g	153	8	is	be	VBZ
cord-334133-61om170g	153	9	highly	highly	RB
cord-334133-61om170g	153	10	hydrophilic	hydrophilic	JJ
cord-334133-61om170g	153	11	,	,	,
cord-334133-61om170g	153	12	with	with	IN
cord-334133-61om170g	153	13	values	value	NNS
cord-334133-61om170g	153	14	of	of	IN
cord-334133-61om170g	153	15	mainly	mainly	RB
cord-334133-61om170g	153	16	À1	À1	NNP
cord-334133-61om170g	153	17	,	,	,
cord-334133-61om170g	153	18	suggesting	suggest	VBG
cord-334133-61om170g	153	19	that	that	IN
cord-334133-61om170g	153	20	it	-PRON-	PRP
cord-334133-61om170g	153	21	is	be	VBZ
cord-334133-61om170g	153	22	exposed	expose	VBN
cord-334133-61om170g	153	23	to	to	IN
cord-334133-61om170g	153	24	solvent	solvent	NN
cord-334133-61om170g	153	25	.	.	.
cord-334133-61om170g	154	1	Essentially	essentially	RB
cord-334133-61om170g	154	2	the	the	DT
cord-334133-61om170g	154	3	same	same	JJ
cord-334133-61om170g	154	4	conclusions	conclusion	NNS
cord-334133-61om170g	154	5	were	be	VBD
cord-334133-61om170g	154	6	reached	reach	VBN
cord-334133-61om170g	154	7	(	(	-LRB-
cord-334133-61om170g	154	8	data	datum	NNS
cord-334133-61om170g	154	9	not	not	RB
cord-334133-61om170g	154	10	shown	show	VBN
cord-334133-61om170g	154	11	)	)	-RRB-
cord-334133-61om170g	154	12	using	use	VBG
cord-334133-61om170g	154	13	other	other	JJ
cord-334133-61om170g	154	14	hydropathy	hydropathy	JJ
cord-334133-61om170g	154	15	prediction	prediction	NN
cord-334133-61om170g	154	16	algorithms	algorithm	NNS
cord-334133-61om170g	154	17	(	(	-LRB-
cord-334133-61om170g	154	18	Eisenberg	Eisenberg	NNP
cord-334133-61om170g	154	19	et	et	NNP
cord-334133-61om170g	154	20	al	al	NNP
cord-334133-61om170g	154	21	.	.	NNP
cord-334133-61om170g	154	22	,	,	,
cord-334133-61om170g	154	23	1984	1984	CD
cord-334133-61om170g	154	24	;	;	:
cord-334133-61om170g	154	25	Hopp	Hopp	NNP
cord-334133-61om170g	154	26	and	and	CC
cord-334133-61om170g	154	27	Woods	Woods	NNP
cord-334133-61om170g	154	28	,	,	,
cord-334133-61om170g	154	29	1981	1981	CD
cord-334133-61om170g	154	30	;	;	:
cord-334133-61om170g	154	31	Sweet	Sweet	NNP
cord-334133-61om170g	154	32	and	and	CC
cord-334133-61om170g	154	33	Eisenberg	Eisenberg	NNP
cord-334133-61om170g	154	34	,	,	,
cord-334133-61om170g	154	35	1983	1983	CD
cord-334133-61om170g	154	36	)	)	-RRB-
cord-334133-61om170g	154	37	.	.	.
cord-334133-61om170g	155	1	Five	five	CD
cord-334133-61om170g	155	2	regions	region	NNS
cord-334133-61om170g	155	3	(	(	-LRB-
cord-334133-61om170g	155	4	690	690	CD
cord-334133-61om170g	155	5	-694	-694	NN
cord-334133-61om170g	155	6	,	,	,
cord-334133-61om170g	155	7	704	704	CD
cord-334133-61om170g	155	8	-711	-711	JJ
cord-334133-61om170g	155	9	,	,	,
cord-334133-61om170g	155	10	740	740	CD
cord-334133-61om170g	155	11	-747	-747	NN
cord-334133-61om170g	155	12	,	,	,
cord-334133-61om170g	155	13	758	758	CD
cord-334133-61om170g	155	14	-766	-766	NN
cord-334133-61om170g	155	15	,	,	,
cord-334133-61om170g	155	16	and	and	CC
cord-334133-61om170g	155	17	779	779	CD
cord-334133-61om170g	155	18	-793	-793	NN
cord-334133-61om170g	155	19	)	)	-RRB-
cord-334133-61om170g	155	20	have	have	VBP
cord-334133-61om170g	155	21	a	a	DT
cord-334133-61om170g	155	22	-	-	HYPH
cord-334133-61om170g	155	23	helix	helix	NN
cord-334133-61om170g	155	24	potentials	potential	NNS
cord-334133-61om170g	155	25	of	of	IN
cord-334133-61om170g	155	26	>	>	XX
cord-334133-61om170g	155	27	1.03	1.03	CD
cord-334133-61om170g	155	28	(	(	-LRB-
cord-334133-61om170g	155	29	Fig	Fig	NNP
cord-334133-61om170g	155	30	.	.	.
cord-334133-61om170g	155	31	3b	3b	CD
cord-334133-61om170g	155	32	)	)	-RRB-
cord-334133-61om170g	155	33	,	,	,
cord-334133-61om170g	155	34	and	and	CC
cord-334133-61om170g	155	35	four	four	CD
cord-334133-61om170g	155	36	regions	region	NNS
cord-334133-61om170g	155	37	(	(	-LRB-
cord-334133-61om170g	155	38	690	690	CD
cord-334133-61om170g	155	39	-719	-719	NN
cord-334133-61om170g	155	40	,	,	,
cord-334133-61om170g	155	41	753	753	CD
cord-334133-61om170g	155	42	-	-	HYPH
cord-334133-61om170g	155	43	761	761	CD
cord-334133-61om170g	155	44	,	,	,
cord-334133-61om170g	155	45	770	770	CD
cord-334133-61om170g	155	46	-777	-777	NN
cord-334133-61om170g	155	47	,	,	,
cord-334133-61om170g	155	48	and	and	CC
cord-334133-61om170g	155	49	779	779	CD
cord-334133-61om170g	155	50	-	-	HYPH
cord-334133-61om170g	155	51	788	788	CD
cord-334133-61om170g	155	52	)	)	-RRB-
cord-334133-61om170g	155	53	have	have	VBP
cord-334133-61om170g	155	54	h	h	NN
cord-334133-61om170g	155	55	-	-	HYPH
cord-334133-61om170g	155	56	sheet	sheet	NN
cord-334133-61om170g	155	57	values	value	NNS
cord-334133-61om170g	155	58	of	of	IN
cord-334133-61om170g	155	59	>	>	XX
cord-334133-61om170g	155	60	1.05	1.05	CD
cord-334133-61om170g	155	61	(	(	-LRB-
cord-334133-61om170g	155	62	Fig	Fig	NNP
cord-334133-61om170g	155	63	.	.	.
cord-334133-61om170g	155	64	3c	3c	NNP
cord-334133-61om170g	155	65	)	)	-RRB-
cord-334133-61om170g	155	66	.	.	.
cord-334133-61om170g	156	1	The	the	DT
cord-334133-61om170g	156	2	most	most	RBS
cord-334133-61om170g	156	3	likely	likely	JJ
cord-334133-61om170g	156	4	conformation	conformation	NN
cord-334133-61om170g	156	5	is	be	VBZ
cord-334133-61om170g	156	6	that	that	IN
cord-334133-61om170g	156	7	with	with	IN
cord-334133-61om170g	156	8	the	the	DT
cord-334133-61om170g	156	9	highest	high	JJS
cord-334133-61om170g	156	10	predicted	predict	VBN
cord-334133-61om170g	156	11	value	value	NN
cord-334133-61om170g	156	12	(	(	-LRB-
cord-334133-61om170g	156	13	Chou	Chou	NNP
cord-334133-61om170g	156	14	and	and	CC
cord-334133-61om170g	156	15	Fasman	Fasman	NNP
cord-334133-61om170g	156	16	,	,	,
cord-334133-61om170g	156	17	1978	1978	CD
cord-334133-61om170g	156	18	)	)	-RRB-
cord-334133-61om170g	156	19	.	.	.
cord-334133-61om170g	157	1	Thus	thus	RB
cord-334133-61om170g	157	2	,	,	,
cord-334133-61om170g	157	3	690	690	CD
cord-334133-61om170g	157	4	-719	-719	NN
cord-334133-61om170g	157	5	(	(	-LRB-
cord-334133-61om170g	157	6	1.34	1.34	CD
cord-334133-61om170g	157	7	)	)	-RRB-
cord-334133-61om170g	157	8	is	be	VBZ
cord-334133-61om170g	157	9	likely	likely	JJ
cord-334133-61om170g	157	10	to	to	TO
cord-334133-61om170g	157	11	be	be	VB
cord-334133-61om170g	157	12	hsheet	hsheet	NNP
cord-334133-61om170g	157	13	.	.	.
cord-334133-61om170g	158	1	In	in	IN
cord-334133-61om170g	158	2	this	this	DT
cord-334133-61om170g	158	3	region	region	NN
cord-334133-61om170g	158	4	there	there	EX
cord-334133-61om170g	158	5	is	be	VBZ
cord-334133-61om170g	158	6	a	a	DT
cord-334133-61om170g	158	7	dip	dip	NN
cord-334133-61om170g	158	8	to	to	IN
cord-334133-61om170g	158	9	1.05	1.05	CD
cord-334133-61om170g	158	10	at	at	IN
cord-334133-61om170g	158	11	residue	residue	NN
cord-334133-61om170g	158	12	702	702	CD
cord-334133-61om170g	158	13	,	,	,
cord-334133-61om170g	158	14	suggesting	suggest	VBG
cord-334133-61om170g	158	15	that	that	IN
cord-334133-61om170g	158	16	690	690	CD
cord-334133-61om170g	158	17	-	-	SYM
cord-334133-61om170g	158	18	719	719	CD
cord-334133-61om170g	158	19	may	may	MD
cord-334133-61om170g	158	20	comprise	comprise	VB
cord-334133-61om170g	158	21	two	two	CD
cord-334133-61om170g	158	22	discrete	discrete	JJ
cord-334133-61om170g	158	23	regions	region	NNS
cord-334133-61om170g	158	24	(	(	-LRB-
cord-334133-61om170g	158	25	690	690	CD
cord-334133-61om170g	158	26	-701	-701	SYM
cord-334133-61om170g	158	27	and	and	CC
cord-334133-61om170g	158	28	703	703	CD
cord-334133-61om170g	158	29	-	-	SYM
cord-334133-61om170g	158	30	719	719	CD
cord-334133-61om170g	158	31	)	)	-RRB-
cord-334133-61om170g	158	32	.	.	.
cord-334133-61om170g	159	1	This	this	DT
cord-334133-61om170g	159	2	is	be	VBZ
cord-334133-61om170g	159	3	consistent	consistent	JJ
cord-334133-61om170g	159	4	with	with	IN
cord-334133-61om170g	159	5	the	the	DT
cord-334133-61om170g	159	6	two	two	CD
cord-334133-61om170g	159	7	hydropathic	hydropathic	JJ
cord-334133-61om170g	159	8	regions	region	NNS
cord-334133-61om170g	159	9	predicted	predict	VBN
cord-334133-61om170g	159	10	above	above	RB
cord-334133-61om170g	159	11	.	.	.
cord-334133-61om170g	160	1	There	there	EX
cord-334133-61om170g	160	2	are	be	VBP
cord-334133-61om170g	160	3	two	two	CD
cord-334133-61om170g	160	4	regions	region	NNS
cord-334133-61om170g	160	5	with	with	IN
cord-334133-61om170g	160	6	different	different	JJ
cord-334133-61om170g	160	7	conformations	conformation	NNS
cord-334133-61om170g	160	8	adjacent	adjacent	JJ
cord-334133-61om170g	160	9	to	to	IN
cord-334133-61om170g	160	10	each	each	DT
cord-334133-61om170g	160	11	other	other	JJ
cord-334133-61om170g	160	12	at	at	IN
cord-334133-61om170g	160	13	753	753	CD
cord-334133-61om170g	160	14	-	-	HYPH
cord-334133-61om170g	160	15	766	766	CD
cord-334133-61om170g	160	16	,	,	,
cord-334133-61om170g	160	17	with	with	IN
cord-334133-61om170g	160	18	753	753	CD
cord-334133-61om170g	160	19	-761	-761	NN
cord-334133-61om170g	160	20	showing	show	VBG
cord-334133-61om170g	160	21	higher	high	JJR
cord-334133-61om170g	160	22	h	h	NN
cord-334133-61om170g	160	23	-	-	HYPH
cord-334133-61om170g	160	24	sheet	sheet	NN
cord-334133-61om170g	160	25	potential	potential	NN
cord-334133-61om170g	160	26	and	and	CC
cord-334133-61om170g	160	27	761	761	CD
cord-334133-61om170g	160	28	-766	-766	NN
cord-334133-61om170g	160	29	showing	show	VBG
cord-334133-61om170g	160	30	greater	great	JJR
cord-334133-61om170g	160	31	a	a	DT
cord-334133-61om170g	160	32	-	-	HYPH
cord-334133-61om170g	160	33	helix	helix	NN
cord-334133-61om170g	160	34	potential	potential	NN
cord-334133-61om170g	160	35	.	.	.
cord-334133-61om170g	161	1	779	779	CD
cord-334133-61om170g	161	2	-	-	HYPH
cord-334133-61om170g	161	3	788	788	CD
cord-334133-61om170g	161	4	could	could	MD
cord-334133-61om170g	161	5	Fig	Fig	NNP
cord-334133-61om170g	161	6	.	.	.
cord-334133-61om170g	162	1	2	2	LS
cord-334133-61om170g	162	2	.	.	.
cord-334133-61om170g	163	1	Consensus	consensus	NN
cord-334133-61om170g	163	2	sequences	sequence	NNS
cord-334133-61om170g	163	3	for	for	IN
cord-334133-61om170g	163	4	gp41	gp41	NNP
cord-334133-61om170g	163	5	C	c	NN
cord-334133-61om170g	163	6	-	-	HYPH
cord-334133-61om170g	163	7	terminal	terminal	NN
cord-334133-61om170g	163	8	amino	amino	NN
cord-334133-61om170g	163	9	acid	acid	NN
cord-334133-61om170g	163	10	residues	residue	NNS
cord-334133-61om170g	164	1	690	690	CD
cord-334133-61om170g	165	1	-793	-793	NNP
cord-334133-61om170g	165	2	of	of	IN
cord-334133-61om170g	166	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	166	2	clades	clade	VBZ
cord-334133-61om170g	166	3	A	a	DT
cord-334133-61om170g	166	4	to	to	IN
cord-334133-61om170g	166	5	D	d	NN
cord-334133-61om170g	166	6	combined	combine	VBN
cord-334133-61om170g	166	7	(	(	-LRB-
cord-334133-61om170g	166	8	top	top	JJ
cord-334133-61om170g	166	9	line	line	NN
cord-334133-61om170g	166	10	)	)	-RRB-
cord-334133-61om170g	166	11	,	,	,
cord-334133-61om170g	166	12	and	and	CC
cord-334133-61om170g	166	13	for	for	IN
cord-334133-61om170g	166	14	clades	clade	NNS
cord-334133-61om170g	166	15	A	a	VBP
cord-334133-61om170g	166	16	to	to	IN
cord-334133-61om170g	166	17	D	d	NN
cord-334133-61om170g	166	18	individually	individually	RB
cord-334133-61om170g	166	19	.	.	.
cord-334133-61om170g	167	1	The	the	DT
cord-334133-61om170g	167	2	potential	potential	JJ
cord-334133-61om170g	167	3	tyrosine	tyrosine	NN
cord-334133-61om170g	167	4	-	-	HYPH
cord-334133-61om170g	167	5	dependent	dependent	JJ
cord-334133-61om170g	167	6	sorting	sorting	NN
cord-334133-61om170g	167	7	signals	signal	NNS
cord-334133-61om170g	167	8	are	be	VBP
cord-334133-61om170g	167	9	in	in	IN
cord-334133-61om170g	167	10	red	red	NN
cord-334133-61om170g	167	11	.	.	.
cord-334133-61om170g	168	1	A	a	DT
cord-334133-61om170g	168	2	potential	potential	JJ
cord-334133-61om170g	168	3	di	di	FW
cord-334133-61om170g	168	4	-	-	HYPH
cord-334133-61om170g	168	5	leucine	leucine	NN
cord-334133-61om170g	168	6	signal	signal	NN
cord-334133-61om170g	168	7	is	be	VBZ
cord-334133-61om170g	168	8	pink	pink	JJ
cord-334133-61om170g	168	9	.	.	.
cord-334133-61om170g	169	1	Residues	residue	NNS
cord-334133-61om170g	169	2	common	common	JJ
cord-334133-61om170g	169	3	to	to	IN
cord-334133-61om170g	169	4	the	the	DT
cord-334133-61om170g	169	5	majority	majority	NN
cord-334133-61om170g	169	6	of	of	IN
cord-334133-61om170g	169	7	sequences	sequence	NNS
cord-334133-61om170g	169	8	are	be	VBP
cord-334133-61om170g	169	9	in	in	IN
cord-334133-61om170g	169	10	black	black	JJ
cord-334133-61om170g	169	11	,	,	,
cord-334133-61om170g	169	12	while	while	IN
cord-334133-61om170g	169	13	residues	residue	NNS
cord-334133-61om170g	169	14	that	that	WDT
cord-334133-61om170g	169	15	vary	vary	VBP
cord-334133-61om170g	169	16	are	be	VBP
cord-334133-61om170g	169	17	in	in	IN
cord-334133-61om170g	169	18	green	green	JJ
cord-334133-61om170g	169	19	.	.	.
cord-334133-61om170g	170	1	Where	where	WRB
cord-334133-61om170g	170	2	two	two	CD
cord-334133-61om170g	170	3	residues	residue	NNS
cord-334133-61om170g	170	4	are	be	VBP
cord-334133-61om170g	170	5	equally	equally	RB
cord-334133-61om170g	170	6	represented	represent	VBN
cord-334133-61om170g	170	7	between	between	IN
cord-334133-61om170g	170	8	the	the	DT
cord-334133-61om170g	170	9	consensus	consensus	NN
cord-334133-61om170g	170	10	sequences	sequence	NNS
cord-334133-61om170g	170	11	of	of	IN
cord-334133-61om170g	170	12	the	the	DT
cord-334133-61om170g	170	13	four	four	CD
cord-334133-61om170g	170	14	clades	clade	NNS
cord-334133-61om170g	170	15	,	,	,
cord-334133-61om170g	170	16	the	the	DT
cord-334133-61om170g	170	17	overall	overall	JJ
cord-334133-61om170g	170	18	consensus	consensus	NN
cord-334133-61om170g	170	19	sequence	sequence	NN
cord-334133-61om170g	170	20	is	be	VBZ
cord-334133-61om170g	170	21	based	base	VBN
cord-334133-61om170g	170	22	on	on	IN
cord-334133-61om170g	170	23	the	the	DT
cord-334133-61om170g	170	24	larger	large	JJR
cord-334133-61om170g	170	25	number	number	NN
cord-334133-61om170g	170	26	of	of	IN
cord-334133-61om170g	170	27	sequences	sequence	NNS
cord-334133-61om170g	170	28	analyzed	analyze	VBN
cord-334133-61om170g	170	29	.	.	.
cord-334133-61om170g	171	1	The	the	DT
cord-334133-61om170g	171	2	proposed	propose	VBN
cord-334133-61om170g	171	3	first	first	RB
cord-334133-61om170g	171	4	,	,	,
cord-334133-61om170g	171	5	second	second	JJ
cord-334133-61om170g	171	6	,	,	,
cord-334133-61om170g	171	7	and	and	CC
cord-334133-61om170g	171	8	third	third	JJ
cord-334133-61om170g	171	9	MSDs	msd	NNS
cord-334133-61om170g	171	10	are	be	VBP
cord-334133-61om170g	171	11	overlined	overline	VBN
cord-334133-61om170g	171	12	.	.	.
cord-334133-61om170g	172	1	Underlined	Underlined	NNP
cord-334133-61om170g	172	2	is	be	VBZ
cord-334133-61om170g	172	3	the	the	DT
cord-334133-61om170g	172	4	antigenically	antigenically	RB
cord-334133-61om170g	172	5	active	active	JJ
cord-334133-61om170g	172	6	Kennedy	Kennedy	NNP
cord-334133-61om170g	172	7	sequence	sequence	NN
cord-334133-61om170g	172	8	.	.	.
cord-334133-61om170g	173	1	be	be	VB
cord-334133-61om170g	173	2	either	either	CC
cord-334133-61om170g	173	3	a	a	DT
cord-334133-61om170g	173	4	-	-	HYPH
cord-334133-61om170g	173	5	helix	helix	NN
cord-334133-61om170g	173	6	or	or	CC
cord-334133-61om170g	173	7	h	h	NN
cord-334133-61om170g	173	8	-	-	HYPH
cord-334133-61om170g	173	9	sheet	sheet	NN
cord-334133-61om170g	173	10	.	.	.
cord-334133-61om170g	174	1	The	the	DT
cord-334133-61om170g	174	2	shows	show	NNS
cord-334133-61om170g	174	3	no	no	DT
cord-334133-61om170g	174	4	potential	potential	NN
cord-334133-61om170g	174	5	for	for	IN
cord-334133-61om170g	174	6	h	h	NN
cord-334133-61om170g	174	7	-	-	HYPH
cord-334133-61om170g	174	8	sheet	sheet	NN
cord-334133-61om170g	174	9	formation	formation	NN
cord-334133-61om170g	174	10	with	with	IN
cord-334133-61om170g	174	11	values	value	NNS
cord-334133-61om170g	174	12	<	<	XX
cord-334133-61om170g	174	13	0.95	0.95	CD
cord-334133-61om170g	174	14	.	.	.
cord-334133-61om170g	175	1	However	however	RB
cord-334133-61om170g	175	2	,	,	,
cord-334133-61om170g	175	3	740	740	CD
cord-334133-61om170g	175	4	-747	-747	NN
cord-334133-61om170g	175	5	of	of	IN
cord-334133-61om170g	175	6	the	the	DT
cord-334133-61om170g	175	7	Kennedy	Kennedy	NNP
cord-334133-61om170g	175	8	region	region	NN
cord-334133-61om170g	176	1	that	that	IN
cord-334133-61om170g	176	2	in	in	IN
cord-334133-61om170g	176	3	clade	clade	NN
cord-334133-61om170g	176	4	B	b	NN
cord-334133-61om170g	176	5	TCLA	TCLA	NNP
cord-334133-61om170g	176	6	viruses	virus	NNS
cord-334133-61om170g	176	7	contains	contain	VBZ
cord-334133-61om170g	176	8	the	the	DT
cord-334133-61om170g	176	9	highly	highly	RB
cord-334133-61om170g	176	10	immunogenic	immunogenic	JJ
cord-334133-61om170g	176	11	and	and	CC
cord-334133-61om170g	176	12	anti	anti	JJ
cord-334133-61om170g	176	13	-	-	JJ
cord-334133-61om170g	176	14	genic	genic	JJ
cord-334133-61om170g	176	15	epitope	epitope	NN
cord-334133-61om170g	176	16	740	740	CD
cord-334133-61om170g	176	17	IEEE	IEEE	NNP
cord-334133-61om170g	176	18	743	743	CD
cord-334133-61om170g	177	1	(	(	-LRB-
cord-334133-61om170g	177	2	Cleveland	Cleveland	NNP
cord-334133-61om170g	177	3	et	et	NNP
cord-334133-61om170g	177	4	al	al	NNP
cord-334133-61om170g	177	5	.	.	NNP
cord-334133-61om170g	177	6	,	,	,
cord-334133-61om170g	177	7	2000a	2000a	CD
cord-334133-61om170g	177	8	)	)	-RRB-
cord-334133-61om170g	177	9	may	may	MD
cord-334133-61om170g	177	10	form	form	VB
cord-334133-61om170g	177	11	an	an	DT
cord-334133-61om170g	177	12	a	a	DT
cord-334133-61om170g	177	13	-	-	HYPH
cord-334133-61om170g	177	14	helix	helix	NN
cord-334133-61om170g	177	15	(	(	-LRB-
cord-334133-61om170g	177	16	>	>	NFP
cord-334133-61om170g	177	17	1.03	1.03	CD
cord-334133-61om170g	177	18	)	)	-RRB-
cord-334133-61om170g	177	19	.	.	.
cord-334133-61om170g	178	1	There	there	EX
cord-334133-61om170g	178	2	are	be	VBP
cord-334133-61om170g	178	3	potential	potential	JJ
cord-334133-61om170g	178	4	h	h	NN
cord-334133-61om170g	178	5	-	-	HYPH
cord-334133-61om170g	178	6	turns	turn	VBZ
cord-334133-61om170g	178	7	at	at	IN
cord-334133-61om170g	178	8	702	702	CD
cord-334133-61om170g	178	9	,	,	,
cord-334133-61om170g	178	10	721	721	CD
cord-334133-61om170g	178	11	,	,	,
cord-334133-61om170g	178	12	731	731	CD
cord-334133-61om170g	178	13	,	,	,
cord-334133-61om170g	178	14	733	733	CD
cord-334133-61om170g	178	15	,	,	,
cord-334133-61om170g	178	16	748	748	CD
cord-334133-61om170g	178	17	,	,	,
cord-334133-61om170g	178	18	768	768	CD
cord-334133-61om170g	178	19	,	,	,
cord-334133-61om170g	178	20	and	and	CC
cord-334133-61om170g	178	21	778	778	CD
cord-334133-61om170g	178	22	(	(	-LRB-
cord-334133-61om170g	178	23	Fig	Fig	NNP
cord-334133-61om170g	178	24	.	.	.
cord-334133-61om170g	178	25	3d	3d	NNP
cord-334133-61om170g	178	26	)	)	-RRB-
cord-334133-61om170g	178	27	.	.	.
cord-334133-61om170g	179	1	The	the	DT
cord-334133-61om170g	179	2	h	h	NN
cord-334133-61om170g	179	3	-	-	HYPH
cord-334133-61om170g	179	4	turn	turn	NN
cord-334133-61om170g	179	5	at	at	IN
cord-334133-61om170g	179	6	702	702	CD
cord-334133-61om170g	179	7	is	be	VBZ
cord-334133-61om170g	179	8	consistent	consistent	JJ
cord-334133-61om170g	179	9	with	with	IN
cord-334133-61om170g	179	10	the	the	DT
cord-334133-61om170g	179	11	hydropathy	hydropathy	NNP
cord-334133-61om170g	179	12	and	and	CC
cord-334133-61om170g	179	13	h	h	NN
cord-334133-61om170g	179	14	-	-	HYPH
cord-334133-61om170g	179	15	sheet	sheet	NN
cord-334133-61om170g	179	16	predictions	prediction	NNS
cord-334133-61om170g	179	17	that	that	IN
cord-334133-61om170g	179	18	this	this	DT
cord-334133-61om170g	179	19	links	link	VBZ
cord-334133-61om170g	179	20	two	two	CD
cord-334133-61om170g	179	21	discrete	discrete	JJ
cord-334133-61om170g	179	22	MSDs	msd	NNS
cord-334133-61om170g	179	23	.	.	.
cord-334133-61om170g	180	1	Residue	residue	NN
cord-334133-61om170g	180	2	721	721	CD
cord-334133-61om170g	180	3	P	p	NN
cord-334133-61om170g	180	4	is	be	VBZ
cord-334133-61om170g	180	5	present	present	JJ
cord-334133-61om170g	180	6	in	in	IN
cord-334133-61om170g	180	7	most	most	JJS
cord-334133-61om170g	180	8	of	of	IN
cord-334133-61om170g	180	9	the	the	DT
cord-334133-61om170g	180	10	first	first	JJ
cord-334133-61om170g	180	11	tyrosine	tyrosine	NN
cord-334133-61om170g	180	12	-	-	HYPH
cord-334133-61om170g	180	13	dependent	dependent	JJ
cord-334133-61om170g	180	14	sorting	sorting	NN
cord-334133-61om170g	180	15	signals	signal	NNS
cord-334133-61om170g	180	16	(	(	-LRB-
cord-334133-61om170g	180	17	719	719	CD
cord-334133-61om170g	180	18	YSPL	YSPL	NNP
cord-334133-61om170g	180	19	722	722	CD
cord-334133-61om170g	180	20	)	)	-RRB-
cord-334133-61om170g	180	21	and	and	CC
cord-334133-61om170g	180	22	is	be	VBZ
cord-334133-61om170g	180	23	discussed	discuss	VBN
cord-334133-61om170g	180	24	later	later	RB
cord-334133-61om170g	180	25	.	.	.
cord-334133-61om170g	181	1	The	the	DT
cord-334133-61om170g	181	2	Kennedy	Kennedy	NNP
cord-334133-61om170g	181	3	region	region	NN
cord-334133-61om170g	181	4	contains	contain	VBZ
cord-334133-61om170g	181	5	potential	potential	JJ
cord-334133-61om170g	181	6	hturns	hturn	NNS
cord-334133-61om170g	181	7	at	at	IN
cord-334133-61om170g	181	8	731	731	CD
cord-334133-61om170g	181	9	,	,	,
cord-334133-61om170g	181	10	733	733	CD
cord-334133-61om170g	181	11	,	,	,
cord-334133-61om170g	181	12	and	and	CC
cord-334133-61om170g	181	13	748	748	CD
cord-334133-61om170g	181	14	,	,	,
cord-334133-61om170g	181	15	and	and	CC
cord-334133-61om170g	181	16	with	with	IN
cord-334133-61om170g	181	17	the	the	DT
cord-334133-61om170g	181	18	prediction	prediction	NN
cord-334133-61om170g	181	19	of	of	IN
cord-334133-61om170g	181	20	only	only	RB
cord-334133-61om170g	181	21	one	one	CD
cord-334133-61om170g	181	22	short	short	JJ
cord-334133-61om170g	181	23	region	region	NN
cord-334133-61om170g	181	24	of	of	IN
cord-334133-61om170g	181	25	a	a	DT
cord-334133-61om170g	181	26	-	-	HYPH
cord-334133-61om170g	181	27	helix	helix	NN
cord-334133-61om170g	181	28	and	and	CC
cord-334133-61om170g	181	29	no	no	DT
cord-334133-61om170g	181	30	h	h	NN
cord-334133-61om170g	181	31	-	-	HYPH
cord-334133-61om170g	181	32	sheet	sheet	NN
cord-334133-61om170g	181	33	,	,	,
cord-334133-61om170g	181	34	the	the	DT
cord-334133-61om170g	181	35	region	region	NN
cord-334133-61om170g	181	36	is	be	VBZ
cord-334133-61om170g	181	37	probably	probably	RB
cord-334133-61om170g	181	38	unstructured	unstructured	JJ
cord-334133-61om170g	181	39	.	.	.
cord-334133-61om170g	182	1	The	the	DT
cord-334133-61om170g	182	2	potential	potential	JJ
cord-334133-61om170g	182	3	h	h	NN
cord-334133-61om170g	182	4	-	-	HYPH
cord-334133-61om170g	182	5	turn	turn	NN
cord-334133-61om170g	182	6	at	at	IN
cord-334133-61om170g	182	7	749	749	CD
cord-334133-61om170g	182	8	R	r	NN
cord-334133-61om170g	182	9	might	may	MD
cord-334133-61om170g	182	10	be	be	VB
cord-334133-61om170g	182	11	important	important	JJ
cord-334133-61om170g	182	12	for	for	IN
cord-334133-61om170g	182	13	maintaining	maintain	VBG
cord-334133-61om170g	182	14	the	the	DT
cord-334133-61om170g	182	15	complex	complex	JJ
cord-334133-61om170g	182	16	conformational	conformational	JJ
cord-334133-61om170g	182	17	neutralizing	neutralize	VBG
cord-334133-61om170g	182	18	epitope	epitope	NN
cord-334133-61om170g	182	19	746	746	CD
cord-334133-61om170g	182	20	ERDRD	ERDRD	NNP
cord-334133-61om170g	182	21	750	750	CD
cord-334133-61om170g	182	22	found	find	VBD
cord-334133-61om170g	182	23	in	in	IN
cord-334133-61om170g	182	24	clade	clade	NN
cord-334133-61om170g	182	25	B	b	NN
cord-334133-61om170g	182	26	virions	virion	NNS
cord-334133-61om170g	183	1	(	(	-LRB-
cord-334133-61om170g	183	2	Buratti	Buratti	NNP
cord-334133-61om170g	183	3	et	et	NNP
cord-334133-61om170g	183	4	al	al	NNP
cord-334133-61om170g	183	5	.	.	NNP
cord-334133-61om170g	183	6	,	,	,
cord-334133-61om170g	183	7	1998	1998	CD
cord-334133-61om170g	183	8	;	;	:
cord-334133-61om170g	183	9	Cheung	Cheung	NNP
cord-334133-61om170g	183	10	et	et	NNP
cord-334133-61om170g	183	11	al	al	NNP
cord-334133-61om170g	183	12	.	.	NNP
cord-334133-61om170g	183	13	,	,	,
cord-334133-61om170g	183	14	2005	2005	CD
cord-334133-61om170g	183	15	;	;	:
cord-334133-61om170g	183	16	Cleveland	Cleveland	NNP
cord-334133-61om170g	183	17	et	et	NNP
cord-334133-61om170g	183	18	al	al	NNP
cord-334133-61om170g	183	19	.	.	.
cord-334133-61om170g	184	1	,	,	,
cord-334133-61om170g	184	2	2000a	2000a	CD
cord-334133-61om170g	185	1	Cleveland	Cleveland	NNP
cord-334133-61om170g	185	2	et	et	NNP
cord-334133-61om170g	185	3	al	al	NNP
cord-334133-61om170g	185	4	.	.	.
cord-334133-61om170g	186	1	,	,	,
cord-334133-61om170g	186	2	,	,	,
cord-334133-61om170g	186	3	b	b	NN
cord-334133-61om170g	186	4	,	,	,
cord-334133-61om170g	186	5	2003	2003	CD
cord-334133-61om170g	186	6	Heap	Heap	NNP
cord-334133-61om170g	186	7	et	et	NNP
cord-334133-61om170g	186	8	al	al	NNP
cord-334133-61om170g	186	9	.	.	.
cord-334133-61om170g	187	1	,	,	,
cord-334133-61om170g	187	2	2005	2005	CD
cord-334133-61om170g	187	3	;	;	:
cord-334133-61om170g	187	4	McLain	McLain	NNP
cord-334133-61om170g	187	5	et	et	NNP
cord-334133-61om170g	187	6	al	al	NNP
cord-334133-61om170g	187	7	.	.	.
cord-334133-61om170g	188	1	,	,	,
cord-334133-61om170g	188	2	2001	2001	CD
cord-334133-61om170g	188	3	;	;	:
cord-334133-61om170g	188	4	Reading	read	VBG
cord-334133-61om170g	188	5	et	et	FW
cord-334133-61om170g	188	6	al	al	NNP
cord-334133-61om170g	188	7	.	.	NNP
cord-334133-61om170g	188	8	,	,	,
cord-334133-61om170g	188	9	2003	2003	CD
cord-334133-61om170g	189	1	;	;	:
cord-334133-61om170g	189	2	Vella	Vella	NNP
cord-334133-61om170g	189	3	et	et	NNP
cord-334133-61om170g	189	4	al	al	NNP
cord-334133-61om170g	189	5	.	.	NNP
cord-334133-61om170g	189	6	,	,	,
cord-334133-61om170g	189	7	1993	1993	CD
cord-334133-61om170g	189	8	)	)	-RRB-
cord-334133-61om170g	189	9	.	.	.
cord-334133-61om170g	190	1	h	h	LS
cord-334133-61om170g	190	2	-	-	HYPH
cord-334133-61om170g	190	3	turns	turn	VBZ
cord-334133-61om170g	190	4	at	at	IN
cord-334133-61om170g	190	5	768	768	CD
cord-334133-61om170g	190	6	and	and	CC
cord-334133-61om170g	190	7	778	778	CD
cord-334133-61om170g	190	8	would	would	MD
cord-334133-61om170g	190	9	occur	occur	VB
cord-334133-61om170g	190	10	after	after	IN
cord-334133-61om170g	190	11	the	the	DT
cord-334133-61om170g	190	12	putative	putative	JJ
cord-334133-61om170g	190	13	third	third	JJ
cord-334133-61om170g	190	14	MSD	MSD	NNP
cord-334133-61om170g	190	15	(	(	-LRB-
cord-334133-61om170g	190	16	see	see	VB
cord-334133-61om170g	190	17	below	below	RB
cord-334133-61om170g	190	18	)	)	-RRB-
cord-334133-61om170g	190	19	.	.	.
cord-334133-61om170g	191	1	There	there	EX
cord-334133-61om170g	191	2	are	be	VBP
cord-334133-61om170g	191	3	four	four	CD
cord-334133-61om170g	191	4	highly	highly	RB
cord-334133-61om170g	191	5	non	non	JJ
cord-334133-61om170g	191	6	-	-	JJ
cord-334133-61om170g	191	7	polar	polar	JJ
cord-334133-61om170g	191	8	regions	region	NNS
cord-334133-61om170g	191	9	(	(	-LRB-
cord-334133-61om170g	191	10	694	694	CD
cord-334133-61om170g	191	11	-699	-699	NN
cord-334133-61om170g	191	12	,	,	,
cord-334133-61om170g	191	13	708	708	CD
cord-334133-61om170g	191	14	-711	-711	JJ
cord-334133-61om170g	191	15	,	,	,
cord-334133-61om170g	191	16	720	720	CD
cord-334133-61om170g	191	17	-	-	SYM
cord-334133-61om170g	191	18	725	725	CD
cord-334133-61om170g	191	19	,	,	,
cord-334133-61om170g	191	20	and	and	CC
cord-334133-61om170g	191	21	759	759	CD
cord-334133-61om170g	191	22	-	-	HYPH
cord-334133-61om170g	191	23	762	762	CD
cord-334133-61om170g	191	24	)	)	-RRB-
cord-334133-61om170g	191	25	(	(	-LRB-
cord-334133-61om170g	191	26	Fig	Fig	NNP
cord-334133-61om170g	191	27	.	.	.
cord-334133-61om170g	191	28	3e	3e	NNP
cord-334133-61om170g	191	29	)	)	-RRB-
cord-334133-61om170g	191	30	.	.	.
cord-334133-61om170g	192	1	Regions	region	NNS
cord-334133-61om170g	192	2	694	694	CD
cord-334133-61om170g	192	3	-699	-699	NN
cord-334133-61om170g	192	4	and	and	CC
cord-334133-61om170g	192	5	708	708	CD
cord-334133-61om170g	192	6	-711	-711	JJ
cord-334133-61om170g	192	7	coincide	coincide	NN
cord-334133-61om170g	192	8	with	with	IN
cord-334133-61om170g	192	9	the	the	DT
cord-334133-61om170g	192	10	MSD	MSD	NNP
cord-334133-61om170g	192	11	1	1	CD
cord-334133-61om170g	192	12	and	and	CC
cord-334133-61om170g	192	13	2	2	CD
cord-334133-61om170g	192	14	predicted	predict	VBD
cord-334133-61om170g	192	15	above	above	RB
cord-334133-61om170g	192	16	.	.	.
cord-334133-61om170g	193	1	The	the	DT
cord-334133-61om170g	193	2	unequal	unequal	JJ
cord-334133-61om170g	193	3	polarity	polarity	NN
cord-334133-61om170g	193	4	of	of	IN
cord-334133-61om170g	193	5	these	these	DT
cord-334133-61om170g	193	6	two	two	CD
cord-334133-61om170g	193	7	domains	domain	NNS
cord-334133-61om170g	193	8	adds	add	VBZ
cord-334133-61om170g	193	9	to	to	IN
cord-334133-61om170g	193	10	the	the	DT
cord-334133-61om170g	193	11	suggestion	suggestion	NN
cord-334133-61om170g	193	12	that	that	IN
cord-334133-61om170g	193	13	they	-PRON-	PRP
cord-334133-61om170g	193	14	are	be	VBP
cord-334133-61om170g	193	15	separate	separate	JJ
cord-334133-61om170g	193	16	entities	entity	NNS
cord-334133-61om170g	193	17	.	.	.
cord-334133-61om170g	194	1	Residues	residue	NNS
cord-334133-61om170g	194	2	720	720	CD
cord-334133-61om170g	194	3	-725	-725	RB
cord-334133-61om170g	194	4	contain	contain	VBP
cord-334133-61om170g	194	5	the	the	DT
cord-334133-61om170g	194	6	first	first	JJ
cord-334133-61om170g	194	7	tyrosine	tyrosine	NN
cord-334133-61om170g	194	8	-	-	HYPH
cord-334133-61om170g	194	9	dependent	dependent	JJ
cord-334133-61om170g	194	10	sorting	sorting	NN
cord-334133-61om170g	194	11	signal	signal	NN
cord-334133-61om170g	194	12	,	,	,
cord-334133-61om170g	194	13	but	but	CC
cord-334133-61om170g	194	14	the	the	DT
cord-334133-61om170g	194	15	significance	significance	NN
cord-334133-61om170g	194	16	of	of	IN
cord-334133-61om170g	194	17	its	-PRON-	PRP$
cord-334133-61om170g	194	18	lack	lack	NN
cord-334133-61om170g	194	19	of	of	IN
cord-334133-61om170g	194	20	polarity	polarity	NN
cord-334133-61om170g	194	21	is	be	VBZ
cord-334133-61om170g	194	22	not	not	RB
cord-334133-61om170g	194	23	clear	clear	JJ
cord-334133-61om170g	194	24	.	.	.
cord-334133-61om170g	195	1	Residues	residue	NNS
cord-334133-61om170g	195	2	759	759	CD
cord-334133-61om170g	195	3	-762	-762	NNS
cord-334133-61om170g	195	4	coincide	coincide	VB
cord-334133-61om170g	195	5	with	with	IN
cord-334133-61om170g	195	6	the	the	DT
cord-334133-61om170g	195	7	possible	possible	JJ
cord-334133-61om170g	195	8	location	location	NN
cord-334133-61om170g	195	9	of	of	IN
cord-334133-61om170g	195	10	the	the	DT
cord-334133-61om170g	195	11	third	third	JJ
cord-334133-61om170g	195	12	MSD	MSD	NNP
cord-334133-61om170g	195	13	predicted	predict	VBN
cord-334133-61om170g	195	14	above	above	IN
cord-334133-61om170g	195	15	(	(	-LRB-
cord-334133-61om170g	195	16	754	754	CD
cord-334133-61om170g	195	17	-763	-763	NN
cord-334133-61om170g	195	18	)	)	-RRB-
cord-334133-61om170g	195	19	.	.	.
cord-334133-61om170g	196	1	Region	region	NN
cord-334133-61om170g	196	2	780	780	CD
cord-334133-61om170g	197	1	-793	-793	NNP
cord-334133-61om170g	197	2	is	be	VBZ
cord-334133-61om170g	197	3	moderately	moderately	RB
cord-334133-61om170g	197	4	polar	polar	JJ
cord-334133-61om170g	197	5	and	and	CC
cord-334133-61om170g	197	6	unlikely	unlikely	JJ
cord-334133-61om170g	197	7	to	to	TO
cord-334133-61om170g	197	8	form	form	VB
cord-334133-61om170g	197	9	an	an	DT
cord-334133-61om170g	197	10	MSD	msd	NN
cord-334133-61om170g	197	11	.	.	.
cord-334133-61om170g	198	1	The	the	DT
cord-334133-61om170g	198	2	Kennedy	Kennedy	NNP
cord-334133-61om170g	198	3	region	region	NN
cord-334133-61om170g	198	4	is	be	VBZ
cord-334133-61om170g	198	5	the	the	DT
cord-334133-61om170g	198	6	most	most	RBS
cord-334133-61om170g	198	7	polar	polar	JJ
cord-334133-61om170g	198	8	region	region	NN
cord-334133-61om170g	198	9	in	in	IN
cord-334133-61om170g	198	10	the	the	DT
cord-334133-61om170g	198	11	analyzed	analyze	VBN
cord-334133-61om170g	198	12	sequence	sequence	NN
cord-334133-61om170g	198	13	,	,	,
cord-334133-61om170g	198	14	consistent	consistent	JJ
cord-334133-61om170g	198	15	with	with	IN
cord-334133-61om170g	198	16	it	-PRON-	PRP
cord-334133-61om170g	198	17	being	be	VBG
cord-334133-61om170g	198	18	exposed	expose	VBN
cord-334133-61om170g	198	19	to	to	IN
cord-334133-61om170g	198	20	aqueous	aqueous	JJ
cord-334133-61om170g	198	21	solvent	solvent	NN
cord-334133-61om170g	198	22	and	and	CC
cord-334133-61om170g	198	23	with	with	IN
cord-334133-61om170g	198	24	its	-PRON-	PRP$
cord-334133-61om170g	198	25	antigenic	antigenic	JJ
cord-334133-61om170g	198	26	properties	property	NNS
cord-334133-61om170g	198	27	.	.	.
cord-334133-61om170g	199	1	Regions	region	NNS
cord-334133-61om170g	199	2	694	694	CD
cord-334133-61om170g	199	3	-712	-712	NN
cord-334133-61om170g	200	1	(	(	-LRB-
cord-334133-61om170g	200	2	containing	contain	VBG
cord-334133-61om170g	200	3	the	the	DT
cord-334133-61om170g	200	4	predicted	predict	VBN
cord-334133-61om170g	200	5	MSD	MSD	NNP
cord-334133-61om170g	200	6	1	1	CD
cord-334133-61om170g	200	7	and	and	CC
cord-334133-61om170g	200	8	2	2	CD
cord-334133-61om170g	200	9	at	at	IN
cord-334133-61om170g	200	10	691	691	CD
cord-334133-61om170g	200	11	-	-	SYM
cord-334133-61om170g	200	12	700	700	CD
cord-334133-61om170g	200	13	and	and	CC
cord-334133-61om170g	200	14	703	703	CD
cord-334133-61om170g	200	15	-712	-712	NN
cord-334133-61om170g	200	16	)	)	-RRB-
cord-334133-61om170g	200	17	and	and	CC
cord-334133-61om170g	200	18	755	755	CD
cord-334133-61om170g	200	19	-763	-763	NN
cord-334133-61om170g	200	20	are	be	VBP
cord-334133-61om170g	200	21	likely	likely	JJ
cord-334133-61om170g	200	22	to	to	TO
cord-334133-61om170g	200	23	be	be	VB
cord-334133-61om170g	200	24	inaccessible	inaccessible	JJ
cord-334133-61om170g	200	25	to	to	IN
cord-334133-61om170g	200	26	aqueous	aqueous	JJ
cord-334133-61om170g	200	27	solvent	solvent	NN
cord-334133-61om170g	200	28	(	(	-LRB-
cord-334133-61om170g	200	29	Fig	Fig	NNP
cord-334133-61om170g	200	30	.	.	.
cord-334133-61om170g	200	31	3f	3f	NNP
cord-334133-61om170g	200	32	)	)	-RRB-
cord-334133-61om170g	200	33	.	.	.
cord-334133-61om170g	201	1	The	the	DT
cord-334133-61om170g	201	2	dip	dip	NN
cord-334133-61om170g	201	3	at	at	IN
cord-334133-61om170g	201	4	the	the	DT
cord-334133-61om170g	201	5	center	center	NN
cord-334133-61om170g	201	6	of	of	IN
cord-334133-61om170g	201	7	694	694	CD
cord-334133-61om170g	201	8	-712	-712	JJ
cord-334133-61om170g	201	9	(	(	-LRB-
cord-334133-61om170g	201	10	residue	residue	NNP
cord-334133-61om170g	201	11	703	703	CD
cord-334133-61om170g	201	12	)	)	-RRB-
cord-334133-61om170g	201	13	supports	support	VBZ
cord-334133-61om170g	201	14	the	the	DT
cord-334133-61om170g	201	15	prediction	prediction	NN
cord-334133-61om170g	201	16	that	that	IN
cord-334133-61om170g	201	17	this	this	DT
cord-334133-61om170g	201	18	region	region	NN
cord-334133-61om170g	201	19	comprises	comprise	VBZ
cord-334133-61om170g	201	20	two	two	CD
cord-334133-61om170g	201	21	MSDs	msd	NNS
cord-334133-61om170g	201	22	.	.	.
cord-334133-61om170g	202	1	Region	region	NN
cord-334133-61om170g	202	2	755	755	CD
cord-334133-61om170g	202	3	-	-	HYPH
cord-334133-61om170g	202	4	763	763	CD
cord-334133-61om170g	202	5	coincides	coincide	VBZ
cord-334133-61om170g	202	6	with	with	IN
cord-334133-61om170g	202	7	the	the	DT
cord-334133-61om170g	202	8	predicted	predict	VBN
cord-334133-61om170g	202	9	third	third	JJ
cord-334133-61om170g	202	10	MSD	MSD	NNP
cord-334133-61om170g	202	11	(	(	-LRB-
cord-334133-61om170g	202	12	754	754	CD
cord-334133-61om170g	202	13	-763	-763	NN
cord-334133-61om170g	202	14	)	)	-RRB-
cord-334133-61om170g	202	15	.	.	.
cord-334133-61om170g	203	1	The	the	DT
cord-334133-61om170g	203	2	Kennedy	Kennedy	NNP
cord-334133-61om170g	203	3	region	region	NN
cord-334133-61om170g	203	4	is	be	VBZ
cord-334133-61om170g	203	5	accessible	accessible	JJ
cord-334133-61om170g	203	6	to	to	IN
cord-334133-61om170g	203	7	solvent	solvent	NN
cord-334133-61om170g	203	8	.	.	.
cord-334133-61om170g	204	1	Taken	take	VBN
cord-334133-61om170g	204	2	together	together	RB
cord-334133-61om170g	204	3	,	,	,
cord-334133-61om170g	204	4	these	these	DT
cord-334133-61om170g	204	5	data	datum	NNS
cord-334133-61om170g	204	6	suggest	suggest	VBP
cord-334133-61om170g	204	7	that	that	IN
cord-334133-61om170g	204	8	the	the	DT
cord-334133-61om170g	204	9	gp41	gp41	NNP
cord-334133-61om170g	204	10	of	of	IN
cord-334133-61om170g	204	11	HIV-1	HIV-1	NNP
cord-334133-61om170g	204	12	clades	clade	NNS
cord-334133-61om170g	204	13	A	A	NNP
cord-334133-61om170g	204	14	,	,	,
cord-334133-61om170g	204	15	B	b	NN
cord-334133-61om170g	204	16	,	,	,
cord-334133-61om170g	204	17	C	C	NNP
cord-334133-61om170g	204	18	,	,	,
cord-334133-61om170g	204	19	and	and	CC
cord-334133-61om170g	204	20	D	D	NNP
cord-334133-61om170g	204	21	all	all	DT
cord-334133-61om170g	204	22	have	have	VBP
cord-334133-61om170g	204	23	the	the	DT
cord-334133-61om170g	204	24	potential	potential	NN
cord-334133-61om170g	204	25	to	to	TO
cord-334133-61om170g	204	26	have	have	VB
cord-334133-61om170g	204	27	three	three	CD
cord-334133-61om170g	204	28	MSDs	msd	NNS
cord-334133-61om170g	204	29	in	in	IN
cord-334133-61om170g	204	30	a	a	DT
cord-334133-61om170g	204	31	h	h	NN
cord-334133-61om170g	204	32	-	-	HYPH
cord-334133-61om170g	204	33	sheet	sheet	NN
cord-334133-61om170g	204	34	conformation	conformation	NN
cord-334133-61om170g	204	35	.	.	.
cord-334133-61om170g	205	1	MSD	MSD	NNP
cord-334133-61om170g	205	2	1	1	CD
cord-334133-61om170g	205	3	and	and	CC
cord-334133-61om170g	205	4	2	2	CD
cord-334133-61om170g	205	5	are	be	VBP
cord-334133-61om170g	205	6	connected	connect	VBN
cord-334133-61om170g	205	7	by	by	IN
cord-334133-61om170g	205	8	a	a	DT
cord-334133-61om170g	205	9	short	short	JJ
cord-334133-61om170g	205	10	h	h	NN
cord-334133-61om170g	205	11	-	-	HYPH
cord-334133-61om170g	205	12	turn	turn	NN
cord-334133-61om170g	205	13	(	(	-LRB-
cord-334133-61om170g	205	14	701	701	CD
cord-334133-61om170g	205	15	GL	GL	NNP
cord-334133-61om170g	205	16	702	702	CD
cord-334133-61om170g	205	17	)	)	-RRB-
cord-334133-61om170g	205	18	,	,	,
cord-334133-61om170g	205	19	and	and	CC
cord-334133-61om170g	205	20	MSD	MSD	NNP
cord-334133-61om170g	205	21	2	2	CD
cord-334133-61om170g	205	22	and	and	CC
cord-334133-61om170g	205	23	3	3	CD
cord-334133-61om170g	205	24	support	support	VBP
cord-334133-61om170g	205	25	the	the	DT
cord-334133-61om170g	205	26	highly	highly	RB
cord-334133-61om170g	205	27	antigenic	antigenic	JJ
cord-334133-61om170g	205	28	Kennedy	Kennedy	NNP
cord-334133-61om170g	205	29	sequence	sequence	NN
cord-334133-61om170g	205	30	on	on	IN
cord-334133-61om170g	205	31	the	the	DT
cord-334133-61om170g	205	32	outside	outside	NN
cord-334133-61om170g	205	33	of	of	IN
cord-334133-61om170g	205	34	the	the	DT
cord-334133-61om170g	205	35	cell	cell	NN
cord-334133-61om170g	205	36	or	or	CC
cord-334133-61om170g	205	37	virion	virion	NN
cord-334133-61om170g	205	38	.	.	.
cord-334133-61om170g	206	1	Further	further	RB
cord-334133-61om170g	206	2	the	the	DT
cord-334133-61om170g	206	3	MSDs	msd	NNS
cord-334133-61om170g	206	4	all	all	DT
cord-334133-61om170g	206	5	have	have	VBP
cord-334133-61om170g	206	6	significant	significant	JJ
cord-334133-61om170g	206	7	parallel	parallel	NN
cord-334133-61om170g	206	8	and	and	CC
cord-334133-61om170g	206	9	anti	anti	JJ
cord-334133-61om170g	206	10	-	-	JJ
cord-334133-61om170g	206	11	parallel	parallel	JJ
cord-334133-61om170g	206	12	h	h	NN
cord-334133-61om170g	206	13	-	-	HYPH
cord-334133-61om170g	206	14	strand	strand	NN
cord-334133-61om170g	206	15	potential	potential	NN
cord-334133-61om170g	206	16	(	(	-LRB-
cord-334133-61om170g	206	17	Lifson	Lifson	NNP
cord-334133-61om170g	206	18	and	and	CC
cord-334133-61om170g	206	19	Sander	Sander	NNP
cord-334133-61om170g	206	20	,	,	,
cord-334133-61om170g	206	21	1979	1979	CD
cord-334133-61om170g	206	22	;	;	:
cord-334133-61om170g	206	23	data	datum	NNS
cord-334133-61om170g	206	24	not	not	RB
cord-334133-61om170g	206	25	shown	show	VBN
cord-334133-61om170g	206	26	)	)	-RRB-
cord-334133-61om170g	206	27	.	.	.
cord-334133-61om170g	207	1	The	the	DT
cord-334133-61om170g	207	2	1-and	1-and	CD
cord-334133-61om170g	207	3	3-MSD	3-msd	CD
cord-334133-61om170g	207	4	forms	form	NNS
cord-334133-61om170g	207	5	of	of	IN
cord-334133-61om170g	207	6	gp41	gp41	NNP
cord-334133-61om170g	207	7	are	be	VBP
cord-334133-61om170g	207	8	shown	show	VBN
cord-334133-61om170g	207	9	schematically	schematically	RB
cord-334133-61om170g	207	10	in	in	IN
cord-334133-61om170g	207	11	Figs	fig	NNS
cord-334133-61om170g	207	12	.	.	.
cord-334133-61om170g	208	1	4a	4a	NNP
cord-334133-61om170g	208	2	and	and	CC
cord-334133-61om170g	208	3	b.	b.	NNP
cord-334133-61om170g	209	1	The	the	DT
cord-334133-61om170g	209	2	significance	significance	NN
cord-334133-61om170g	209	3	of	of	IN
cord-334133-61om170g	209	4	the	the	DT
cord-334133-61om170g	209	5	new	new	JJ
cord-334133-61om170g	209	6	positioning	positioning	NN
cord-334133-61om170g	209	7	of	of	IN
cord-334133-61om170g	209	8	the	the	DT
cord-334133-61om170g	209	9	potential	potential	JJ
cord-334133-61om170g	209	10	tyrosine	tyrosine	NN
cord-334133-61om170g	209	11	-	-	HYPH
cord-334133-61om170g	209	12	sorting	sort	VBG
cord-334133-61om170g	209	13	signals	signal	NNS
cord-334133-61om170g	209	14	is	be	VBZ
cord-334133-61om170g	209	15	discussed	discuss	VBN
cord-334133-61om170g	209	16	below	below	RB
cord-334133-61om170g	209	17	.	.	.
cord-334133-61om170g	210	1	While	while	IN
cord-334133-61om170g	210	2	MSDs	msd	NNS
cord-334133-61om170g	210	3	are	be	VBP
cord-334133-61om170g	210	4	typically	typically	RB
cord-334133-61om170g	210	5	a	a	DT
cord-334133-61om170g	210	6	-	-	HYPH
cord-334133-61om170g	210	7	helical	helical	JJ
cord-334133-61om170g	210	8	and	and	CC
cord-334133-61om170g	210	9	approximately	approximately	RB
cord-334133-61om170g	210	10	20	20	CD
cord-334133-61om170g	210	11	residues	residue	NNS
cord-334133-61om170g	210	12	in	in	IN
cord-334133-61om170g	210	13	length	length	NN
cord-334133-61om170g	211	1	(	(	-LRB-
cord-334133-61om170g	211	2	Sabatini	Sabatini	NNP
cord-334133-61om170g	211	3	et	et	NNP
cord-334133-61om170g	211	4	al	al	NNP
cord-334133-61om170g	211	5	.	.	NNP
cord-334133-61om170g	211	6	,	,	,
cord-334133-61om170g	211	7	1982	1982	CD
cord-334133-61om170g	211	8	;	;	:
cord-334133-61om170g	211	9	Singer	singer	NN
cord-334133-61om170g	211	10	,	,	,
cord-334133-61om170g	211	11	1990	1990	CD
cord-334133-61om170g	211	12	)	)	-RRB-
cord-334133-61om170g	211	13	,	,	,
cord-334133-61om170g	211	14	h	h	NN
cord-334133-61om170g	211	15	-	-	HYPH
cord-334133-61om170g	211	16	sheets	sheet	NNS
cord-334133-61om170g	211	17	as	as	RB
cord-334133-61om170g	211	18	short	short	JJ
cord-334133-61om170g	211	19	as	as	IN
cord-334133-61om170g	211	20	7	7	CD
cord-334133-61om170g	211	21	residues	residue	NNS
cord-334133-61om170g	211	22	form	form	VBP
cord-334133-61om170g	211	23	MSDs	msds	NN
cord-334133-61om170g	211	24	as	as	IN
cord-334133-61om170g	211	25	part	part	NN
cord-334133-61om170g	211	26	of	of	IN
cord-334133-61om170g	211	27	transmembrane	transmembrane	NNP
cord-334133-61om170g	211	28	h	h	NN
cord-334133-61om170g	211	29	-	-	HYPH
cord-334133-61om170g	211	30	barrel	barrel	NN
cord-334133-61om170g	211	31	proteins	protein	NNS
cord-334133-61om170g	211	32	of	of	IN
cord-334133-61om170g	211	33	bacteria	bacteria	NNS
cord-334133-61om170g	211	34	,	,	,
cord-334133-61om170g	211	35	choroplasts	choroplast	NNS
cord-334133-61om170g	211	36	,	,	,
cord-334133-61om170g	211	37	and	and	CC
cord-334133-61om170g	211	38	mitochondria	mitochondrion	NNS
cord-334133-61om170g	211	39	(	(	-LRB-
cord-334133-61om170g	211	40	Schultz	Schultz	NNP
cord-334133-61om170g	211	41	,	,	,
cord-334133-61om170g	211	42	2003	2003	CD
cord-334133-61om170g	211	43	)	)	-RRB-
cord-334133-61om170g	211	44	.	.	.
cord-334133-61om170g	212	1	Short	Short	NNP
cord-334133-61om170g	212	2	h	h	NN
cord-334133-61om170g	212	3	-	-	HYPH
cord-334133-61om170g	212	4	turns	turn	NNS
cord-334133-61om170g	212	5	connect	connect	VBP
cord-334133-61om170g	212	6	sequential	sequential	JJ
cord-334133-61om170g	212	7	MSDs	msd	NNS
cord-334133-61om170g	212	8	and	and	CC
cord-334133-61om170g	212	9	do	do	VBP
cord-334133-61om170g	212	10	not	not	RB
cord-334133-61om170g	212	11	normally	normally	RB
cord-334133-61om170g	212	12	occur	occur	VB
cord-334133-61om170g	212	13	within	within	IN
cord-334133-61om170g	212	14	MSDs	msd	NNS
cord-334133-61om170g	212	15	(	(	-LRB-
cord-334133-61om170g	212	16	Jahnig	Jahnig	NNP
cord-334133-61om170g	212	17	,	,	,
cord-334133-61om170g	212	18	1990	1990	CD
cord-334133-61om170g	212	19	)	)	-RRB-
cord-334133-61om170g	212	20	,	,	,
cord-334133-61om170g	212	21	but	but	CC
cord-334133-61om170g	212	22	the	the	DT
cord-334133-61om170g	212	23	h	h	NN
cord-334133-61om170g	212	24	-	-	HYPH
cord-334133-61om170g	212	25	turn	turn	NN
cord-334133-61om170g	212	26	may	may	MD
cord-334133-61om170g	212	27	intrude	intrude	VB
cord-334133-61om170g	212	28	into	into	IN
cord-334133-61om170g	212	29	the	the	DT
cord-334133-61om170g	212	30	membrane	membrane	NN
cord-334133-61om170g	212	31	,	,	,
cord-334133-61om170g	212	32	as	as	IN
cord-334133-61om170g	212	33	suggested	suggest	VBN
cord-334133-61om170g	212	34	for	for	IN
cord-334133-61om170g	212	35	herpes	herpes	NNP
cord-334133-61om170g	212	36	simplex	simplex	NNP
cord-334133-61om170g	212	37	virus	virus	NN
cord-334133-61om170g	212	38	glycoprotein	glycoprotein	NN
cord-334133-61om170g	212	39	B	b	NN
cord-334133-61om170g	212	40	(	(	-LRB-
cord-334133-61om170g	212	41	Pellett	Pellett	NNP
cord-334133-61om170g	212	42	et	et	FW
cord-334133-61om170g	212	43	al	al	NNP
cord-334133-61om170g	212	44	.	.	NNP
cord-334133-61om170g	212	45	,	,	,
cord-334133-61om170g	212	46	1985	1985	CD
cord-334133-61om170g	212	47	)	)	-RRB-
cord-334133-61om170g	212	48	.	.	.
cord-334133-61om170g	213	1	An	an	DT
cord-334133-61om170g	213	2	arginine	arginine	NN
cord-334133-61om170g	213	3	residue	residue	NN
cord-334133-61om170g	213	4	is	be	VBZ
cord-334133-61om170g	213	5	unlikely	unlikely	JJ
cord-334133-61om170g	213	6	to	to	TO
cord-334133-61om170g	213	7	occur	occur	VB
cord-334133-61om170g	213	8	in	in	IN
cord-334133-61om170g	213	9	the	the	DT
cord-334133-61om170g	213	10	middle	middle	NN
cord-334133-61om170g	213	11	of	of	IN
cord-334133-61om170g	213	12	an	an	DT
cord-334133-61om170g	213	13	MSD	MSD	NNP
cord-334133-61om170g	213	14	(	(	-LRB-
cord-334133-61om170g	213	15	Singer	singer	NN
cord-334133-61om170g	213	16	,	,	,
cord-334133-61om170g	213	17	1990	1990	CD
cord-334133-61om170g	213	18	)	)	-RRB-
cord-334133-61om170g	213	19	,	,	,
cord-334133-61om170g	213	20	and	and	CC
cord-334133-61om170g	213	21	R703	r703	NN
cord-334133-61om170g	213	22	of	of	IN
cord-334133-61om170g	213	23	the	the	DT
cord-334133-61om170g	213	24	3-MSD	3-msd	CD
cord-334133-61om170g	213	25	form	form	NN
cord-334133-61om170g	213	26	of	of	IN
cord-334133-61om170g	213	27	gp41	gp41	NNP
cord-334133-61om170g	213	28	is	be	VBZ
cord-334133-61om170g	213	29	predicted	predict	VBN
cord-334133-61om170g	213	30	to	to	TO
cord-334133-61om170g	213	31	be	be	VB
cord-334133-61om170g	213	32	on	on	IN
cord-334133-61om170g	213	33	the	the	DT
cord-334133-61om170g	213	34	membrane	membrane	NN
cord-334133-61om170g	213	35	surface	surface	NN
cord-334133-61om170g	213	36	,	,	,
cord-334133-61om170g	213	37	where	where	WRB
cord-334133-61om170g	213	38	the	the	DT
cord-334133-61om170g	213	39	polar	polar	JJ
cord-334133-61om170g	213	40	head	head	NN
cord-334133-61om170g	213	41	groups	group	NNS
cord-334133-61om170g	213	42	of	of	IN
cord-334133-61om170g	213	43	membrane	membrane	NN
cord-334133-61om170g	213	44	lipids	lipid	NNS
cord-334133-61om170g	213	45	can	can	MD
cord-334133-61om170g	213	46	neutralize	neutralize	VB
cord-334133-61om170g	213	47	its	-PRON-	PRP$
cord-334133-61om170g	213	48	positive	positive	JJ
cord-334133-61om170g	213	49	charge	charge	NN
cord-334133-61om170g	213	50	.	.	.
cord-334133-61om170g	214	1	However	however	RB
cord-334133-61om170g	214	2	,	,	,
cord-334133-61om170g	214	3	we	-PRON-	PRP
cord-334133-61om170g	214	4	shall	shall	MD
cord-334133-61om170g	214	5	suggest	suggest	VB
cord-334133-61om170g	214	6	below	below	IN
cord-334133-61om170g	214	7	that	that	IN
cord-334133-61om170g	214	8	the	the	DT
cord-334133-61om170g	214	9	3-MSD	3-msd	CD
cord-334133-61om170g	214	10	gp41	gp41	NNP
cord-334133-61om170g	214	11	is	be	VBZ
cord-334133-61om170g	214	12	a	a	DT
cord-334133-61om170g	214	13	minority	minority	NN
cord-334133-61om170g	214	14	form	form	NN
cord-334133-61om170g	214	15	that	that	WDT
cord-334133-61om170g	214	16	is	be	VBZ
cord-334133-61om170g	214	17	selectively	selectively	RB
cord-334133-61om170g	214	18	incorporated	incorporate	VBN
cord-334133-61om170g	214	19	into	into	IN
cord-334133-61om170g	214	20	the	the	DT
cord-334133-61om170g	214	21	plasma	plasma	NN
cord-334133-61om170g	214	22	membrane	membrane	NN
cord-334133-61om170g	214	23	and	and	CC
cord-334133-61om170g	214	24	virions	virion	NNS
cord-334133-61om170g	214	25	,	,	,
cord-334133-61om170g	214	26	and	and	CC
cord-334133-61om170g	214	27	that	that	IN
cord-334133-61om170g	214	28	most	most	RBS
cord-334133-61om170g	214	29	intracellular	intracellular	JJ
cord-334133-61om170g	214	30	gp41	gp41	NN
cord-334133-61om170g	214	31	exists	exist	VBZ
cord-334133-61om170g	214	32	in	in	IN
cord-334133-61om170g	214	33	the	the	DT
cord-334133-61om170g	214	34	1-MSD	1-msd	CD
cord-334133-61om170g	214	35	conformation	conformation	NN
cord-334133-61om170g	214	36	.	.	.
cord-334133-61om170g	215	1	Finally	finally	RB
cord-334133-61om170g	215	2	preliminary	preliminary	JJ
cord-334133-61om170g	215	3	sequence	sequence	NN
cord-334133-61om170g	215	4	and	and	CC
cord-334133-61om170g	215	5	structural	structural	JJ
cord-334133-61om170g	215	6	analysis	analysis	NN
cord-334133-61om170g	215	7	suggests	suggest	VBZ
cord-334133-61om170g	215	8	that	that	IN
cord-334133-61om170g	215	9	other	other	JJ
cord-334133-61om170g	215	10	primate	primate	JJ
cord-334133-61om170g	215	11	lentiviruses	lentiviruse	NNS
cord-334133-61om170g	215	12	(	(	-LRB-
cord-334133-61om170g	215	13	HIV-2	HIV-2	NNP
cord-334133-61om170g	215	14	,	,	,
cord-334133-61om170g	215	15	SIV	SIV	NNP
cord-334133-61om170g	215	16	)	)	-RRB-
cord-334133-61om170g	215	17	have	have	VBP
cord-334133-61om170g	215	18	the	the	DT
cord-334133-61om170g	215	19	potential	potential	NN
cord-334133-61om170g	215	20	to	to	TO
cord-334133-61om170g	215	21	form	form	VB
cord-334133-61om170g	215	22	a	a	DT
cord-334133-61om170g	215	23	3-MSD	3-msd	CD
cord-334133-61om170g	215	24	structure	structure	NN
cord-334133-61om170g	215	25	(	(	-LRB-
cord-334133-61om170g	215	26	unpublished	unpublished	JJ
cord-334133-61om170g	215	27	data	datum	NNS
cord-334133-61om170g	215	28	)	)	-RRB-
cord-334133-61om170g	215	29	.	.	.
cord-334133-61om170g	216	1	Gp41	Gp41	NNP
cord-334133-61om170g	216	2	molecules	molecule	NNS
cord-334133-61om170g	216	3	of	of	IN
cord-334133-61om170g	217	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	217	2	clades	clade	VBZ
cord-334133-61om170g	217	3	A	a	VBP
cord-334133-61om170g	217	4	to	to	IN
cord-334133-61om170g	217	5	D	D	NNP
cord-334133-61om170g	217	6	all	all	DT
cord-334133-61om170g	217	7	have	have	VBP
cord-334133-61om170g	217	8	the	the	DT
cord-334133-61om170g	217	9	potential	potential	NN
cord-334133-61om170g	217	10	to	to	TO
cord-334133-61om170g	217	11	form	form	VB
cord-334133-61om170g	217	12	three	three	CD
cord-334133-61om170g	217	13	short	short	JJ
cord-334133-61om170g	217	14	MSDs	msd	NNS
cord-334133-61om170g	217	15	,	,	,
cord-334133-61om170g	217	16	which	which	WDT
cord-334133-61om170g	217	17	most	most	RBS
cord-334133-61om170g	217	18	likely	likely	RB
cord-334133-61om170g	217	19	have	have	VBP
cord-334133-61om170g	217	20	a	a	DT
cord-334133-61om170g	217	21	h	h	NN
cord-334133-61om170g	217	22	-	-	HYPH
cord-334133-61om170g	217	23	sheet	sheet	NN
cord-334133-61om170g	217	24	conformation	conformation	NN
cord-334133-61om170g	217	25	.	.	.
cord-334133-61om170g	218	1	The	the	DT
cord-334133-61om170g	218	2	position	position	NN
cord-334133-61om170g	218	3	of	of	IN
cord-334133-61om170g	218	4	the	the	DT
cord-334133-61om170g	218	5	third	third	JJ
cord-334133-61om170g	218	6	MSD	MSD	NNP
cord-334133-61om170g	218	7	places	place	VBZ
cord-334133-61om170g	218	8	the	the	DT
cord-334133-61om170g	218	9	first	first	JJ
cord-334133-61om170g	218	10	potential	potential	JJ
cord-334133-61om170g	218	11	tyrosine	tyrosine	NN
cord-334133-61om170g	218	12	-	-	HYPH
cord-334133-61om170g	218	13	dependent	dependent	JJ
cord-334133-61om170g	218	14	sorting	sorting	NN
cord-334133-61om170g	218	15	signal	signal	NN
cord-334133-61om170g	218	16	outside	outside	IN
cord-334133-61om170g	218	17	the	the	DT
cord-334133-61om170g	218	18	membrane	membrane	NN
cord-334133-61om170g	218	19	,	,	,
cord-334133-61om170g	218	20	where	where	WRB
cord-334133-61om170g	218	21	it	-PRON-	PRP
cord-334133-61om170g	218	22	is	be	VBZ
cord-334133-61om170g	218	23	non	non	JJ
cord-334133-61om170g	218	24	-	-	JJ
cord-334133-61om170g	218	25	functional	functional	JJ
cord-334133-61om170g	218	26	.	.	.
cord-334133-61om170g	219	1	All	all	DT
cord-334133-61om170g	219	2	viruses	virus	NNS
cord-334133-61om170g	219	3	have	have	VBP
cord-334133-61om170g	219	4	a	a	DT
cord-334133-61om170g	219	5	hydrophilic	hydrophilic	JJ
cord-334133-61om170g	219	6	,	,	,
cord-334133-61om170g	219	7	unstructured	unstructured	JJ
cord-334133-61om170g	219	8	region	region	NN
cord-334133-61om170g	219	9	of	of	IN
cord-334133-61om170g	219	10	41	41	CD
cord-334133-61om170g	219	11	residues	residue	NNS
cord-334133-61om170g	219	12	supported	support	VBN
cord-334133-61om170g	219	13	by	by	IN
cord-334133-61om170g	219	14	MSDs	msd	NNS
cord-334133-61om170g	219	15	2	2	CD
cord-334133-61om170g	219	16	and	and	CC
cord-334133-61om170g	219	17	3	3	CD
cord-334133-61om170g	219	18	that	that	WDT
cord-334133-61om170g	219	19	probably	probably	RB
cord-334133-61om170g	219	20	equates	equate	VBZ
cord-334133-61om170g	219	21	to	to	IN
cord-334133-61om170g	219	22	the	the	DT
cord-334133-61om170g	219	23	antigenically	antigenically	NN
cord-334133-61om170g	219	24	and	and	CC
cord-334133-61om170g	219	25	biologically	biologically	RB
cord-334133-61om170g	219	26	active	active	JJ
cord-334133-61om170g	219	27	minor	minor	JJ
cord-334133-61om170g	219	28	ectodomain	ectodomain	NN
cord-334133-61om170g	219	29	of	of	IN
cord-334133-61om170g	219	30	HIV-1	HIV-1	NNP
cord-334133-61om170g	219	31	clade	clade	NN
cord-334133-61om170g	219	32	B	B	NNP
cord-334133-61om170g	219	33	,	,	,
cord-334133-61om170g	219	34	TCLA	TCLA	NNP
cord-334133-61om170g	219	35	viruses	virus	NNS
cord-334133-61om170g	219	36	.	.	.
cord-334133-61om170g	220	1	The	the	DT
cord-334133-61om170g	220	2	definition	definition	NN
cord-334133-61om170g	220	3	and	and	CC
cord-334133-61om170g	220	4	values	value	NNS
cord-334133-61om170g	220	5	of	of	IN
cord-334133-61om170g	220	6	the	the	DT
cord-334133-61om170g	220	7	peaks	peak	NNS
cord-334133-61om170g	220	8	obtained	obtain	VBN
cord-334133-61om170g	220	9	in	in	IN
cord-334133-61om170g	220	10	the	the	DT
cord-334133-61om170g	220	11	above	above	JJ
cord-334133-61om170g	220	12	analysis	analysis	NN
cord-334133-61om170g	220	13	make	make	VBP
cord-334133-61om170g	220	14	the	the	DT
cord-334133-61om170g	220	15	data	datum	NNS
cord-334133-61om170g	220	16	highly	highly	RB
cord-334133-61om170g	220	17	significant	significant	JJ
cord-334133-61om170g	220	18	.	.	.
cord-334133-61om170g	221	1	The	the	DT
cord-334133-61om170g	221	2	position	position	NN
cord-334133-61om170g	221	3	and	and	CC
cord-334133-61om170g	221	4	number	number	NN
cord-334133-61om170g	221	5	of	of	IN
cord-334133-61om170g	221	6	residues	residue	NNS
cord-334133-61om170g	221	7	in	in	IN
cord-334133-61om170g	221	8	the	the	DT
cord-334133-61om170g	221	9	MSDs	msd	NNS
cord-334133-61om170g	221	10	and	and	CC
cord-334133-61om170g	221	11	other	other	JJ
cord-334133-61om170g	221	12	regions	region	NNS
cord-334133-61om170g	221	13	of	of	IN
cord-334133-61om170g	221	14	interest	interest	NN
cord-334133-61om170g	221	15	are	be	VBP
cord-334133-61om170g	221	16	summarized	summarize	VBN
cord-334133-61om170g	221	17	in	in	IN
cord-334133-61om170g	221	18	Table	Table	NNP
cord-334133-61om170g	221	19	1	1	CD
cord-334133-61om170g	221	20	and	and	CC
cord-334133-61om170g	221	21	1999	1999	CD
cord-334133-61om170g	221	22	;	;	:
cord-334133-61om170g	221	23	Egan	Egan	NNP
cord-334133-61om170g	221	24	et	et	NNP
cord-334133-61om170g	221	25	al	al	NNP
cord-334133-61om170g	221	26	.	.	NNP
cord-334133-61om170g	221	27	,	,	,
cord-334133-61om170g	221	28	1996	1996	CD
cord-334133-61om170g	221	29	;	;	:
cord-334133-61om170g	221	30	Ohno	Ohno	NNP
cord-334133-61om170g	221	31	et	et	NNP
cord-334133-61om170g	221	32	al	al	NNP
cord-334133-61om170g	221	33	.	.	.
cord-334133-61om170g	222	1	,	,	,
cord-334133-61om170g	222	2	1997	1997	CD
cord-334133-61om170g	222	3	;	;	:
cord-334133-61om170g	222	4	Rowell	Rowell	NNP
cord-334133-61om170g	222	5	et	et	FW
cord-334133-61om170g	222	6	al	al	NNP
cord-334133-61om170g	222	7	.	.	.
cord-334133-61om170g	223	1	,	,	,
cord-334133-61om170g	223	2	1995	1995	CD
cord-334133-61om170g	223	3	;	;	:
cord-334133-61om170g	223	4	West	West	NNP
cord-334133-61om170g	223	5	et	et	NNP
cord-334133-61om170g	223	6	al	al	NNP
cord-334133-61om170g	223	7	.	.	NNP
cord-334133-61om170g	223	8	,	,	,
cord-334133-61om170g	223	9	2002	2002	CD
cord-334133-61om170g	223	10	)	)	-RRB-
cord-334133-61om170g	223	11	and	and	CC
cord-334133-61om170g	223	12	basolateral	basolateral	JJ
cord-334133-61om170g	223	13	sorting	sorting	NN
cord-334133-61om170g	224	1	(	(	-LRB-
cord-334133-61om170g	224	2	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	224	3	et	et	FW
cord-334133-61om170g	224	4	al	al	NNP
cord-334133-61om170g	224	5	.	.	NNP
cord-334133-61om170g	224	6	,	,	,
cord-334133-61om170g	224	7	1999	1999	CD
cord-334133-61om170g	224	8	;	;	:
cord-334133-61om170g	225	1	Lodge	Lodge	NNP
cord-334133-61om170g	225	2	et	et	NNP
cord-334133-61om170g	225	3	al	al	NNP
cord-334133-61om170g	225	4	.	.	NNP
cord-334133-61om170g	225	5	,	,	,
cord-334133-61om170g	225	6	1997	1997	CD
cord-334133-61om170g	225	7	;	;	:
cord-334133-61om170g	225	8	Owens	Owens	NNP
cord-334133-61om170g	225	9	et	et	NNP
cord-334133-61om170g	225	10	al	al	NNP
cord-334133-61om170g	225	11	.	.	NNP
cord-334133-61om170g	225	12	,	,	,
cord-334133-61om170g	225	13	1991	1991	CD
cord-334133-61om170g	225	14	)	)	-RRB-
cord-334133-61om170g	225	15	.	.	.
cord-334133-61om170g	226	1	The	the	DT
cord-334133-61om170g	226	2	signal	signal	NN
cord-334133-61om170g	226	3	sequence	sequence	NN
cord-334133-61om170g	226	4	and	and	CC
cord-334133-61om170g	226	5	upstream	upstream	JJ
cord-334133-61om170g	226	6	residues	residue	NNS
cord-334133-61om170g	226	7	are	be	VBP
cord-334133-61om170g	226	8	highly	highly	RB
cord-334133-61om170g	226	9	to	to	IN
cord-334133-61om170g	226	10	very	very	RB
cord-334133-61om170g	226	11	highly	highly	RB
cord-334133-61om170g	226	12	conserved	conserve	VBN
cord-334133-61om170g	226	13	in	in	IN
cord-334133-61om170g	226	14	clades	clade	NNS
cord-334133-61om170g	226	15	A	a	NN
cord-334133-61om170g	226	16	to	to	IN
cord-334133-61om170g	226	17	D	d	NN
cord-334133-61om170g	226	18	:	:	:
cord-334133-61om170g	226	19	716	716	CD
cord-334133-61om170g	226	20	R	r	NN
cord-334133-61om170g	226	21	=	=	SYM
cord-334133-61om170g	226	22	100	100	CD
cord-334133-61om170g	226	23	%	%	NN
cord-334133-61om170g	226	24	,	,	,
cord-334133-61om170g	226	25	717	717	CD
cord-334133-61om170g	226	26	Q	q	NN
cord-334133-61om170g	226	27	=	=	SYM
cord-334133-61om170g	226	28	96.4	96.4	CD
cord-334133-61om170g	226	29	%	%	NN
cord-334133-61om170g	226	30	,	,	,
cord-334133-61om170g	226	31	718	718	CD
cord-334133-61om170g	226	32	G	g	NN
cord-334133-61om170g	226	33	=	=	SYM
cord-334133-61om170g	226	34	99.95	99.95	CD
cord-334133-61om170g	226	35	%	%	NN
cord-334133-61om170g	226	36	,	,	,
cord-334133-61om170g	226	37	719	719	CD
cord-334133-61om170g	226	38	Y	y	NN
cord-334133-61om170g	226	39	=	=	SYM
cord-334133-61om170g	226	40	99.7	99.7	CD
cord-334133-61om170g	226	41	%	%	NN
cord-334133-61om170g	226	42	,	,	,
cord-334133-61om170g	226	43	720	720	CD
cord-334133-61om170g	226	44	S	s	NN
cord-334133-61om170g	226	45	=	=	SYM
cord-334133-61om170g	226	46	99.5	99.5	CD
cord-334133-61om170g	226	47	%	%	NN
cord-334133-61om170g	226	48	,	,	,
cord-334133-61om170g	226	49	721	721	CD
cord-334133-61om170g	226	50	P	p	NN
cord-334133-61om170g	226	51	=	=	SYM
cord-334133-61om170g	226	52	99.8	99.8	CD
cord-334133-61om170g	226	53	%	%	NN
cord-334133-61om170g	226	54	,	,	,
cord-334133-61om170g	226	55	722	722	CD
cord-334133-61om170g	226	56	L	l	NN
cord-334133-61om170g	226	57	=	=	SYM
cord-334133-61om170g	226	58	96.9	96.9	CD
cord-334133-61om170g	226	59	%	%	NN
cord-334133-61om170g	226	60	.	.	.
cord-334133-61om170g	227	1	The	the	DT
cord-334133-61om170g	227	2	glycine	glycine	NN
cord-334133-61om170g	227	3	immediately	immediately	RB
cord-334133-61om170g	227	4	before	before	IN
cord-334133-61om170g	227	5	a	a	DT
cord-334133-61om170g	227	6	tyrosine	tyrosine	NN
cord-334133-61om170g	227	7	signal	signal	NN
cord-334133-61om170g	227	8	signifies	signify	VBZ
cord-334133-61om170g	227	9	that	that	IN
cord-334133-61om170g	227	10	it	-PRON-	PRP
cord-334133-61om170g	227	11	can	can	MD
cord-334133-61om170g	227	12	function	function	VB
cord-334133-61om170g	227	13	in	in	IN
cord-334133-61om170g	227	14	the	the	DT
cord-334133-61om170g	227	15	TGN	TGN	NNP
cord-334133-61om170g	227	16	to	to	TO
cord-334133-61om170g	227	17	target	target	VB
cord-334133-61om170g	227	18	the	the	DT
cord-334133-61om170g	227	19	protein	protein	NN
cord-334133-61om170g	227	20	to	to	IN
cord-334133-61om170g	227	21	lysosomes	lysosome	NNS
cord-334133-61om170g	227	22	.	.	.
cord-334133-61om170g	228	1	Also	also	RB
cord-334133-61om170g	228	2	for	for	IN
cord-334133-61om170g	228	3	signal	signal	NN
cord-334133-61om170g	228	4	functionality	functionality	NN
cord-334133-61om170g	228	5	there	there	EX
cord-334133-61om170g	228	6	is	be	VBZ
cord-334133-61om170g	228	7	a	a	DT
cord-334133-61om170g	228	8	strict	strict	JJ
cord-334133-61om170g	228	9	requirement	requirement	NN
cord-334133-61om170g	228	10	that	that	IN
cord-334133-61om170g	228	11	the	the	DT
cord-334133-61om170g	228	12	tyrosine	tyrosine	NN
cord-334133-61om170g	228	13	residue	residue	NN
cord-334133-61om170g	228	14	is	be	VBZ
cord-334133-61om170g	228	15	the	the	DT
cord-334133-61om170g	228	16	7th	7th	JJ
cord-334133-61om170g	228	17	-11th	-11th	RB
cord-334133-61om170g	228	18	residue	residue	NN
cord-334133-61om170g	228	19	from	from	IN
cord-334133-61om170g	228	20	the	the	DT
cord-334133-61om170g	228	21	membrane	membrane	NN
cord-334133-61om170g	228	22	(	(	-LRB-
cord-334133-61om170g	228	23	Rohrer	Rohrer	NNP
cord-334133-61om170g	228	24	et	et	NNP
cord-334133-61om170g	228	25	al	al	NNP
cord-334133-61om170g	228	26	.	.	NNP
cord-334133-61om170g	228	27	,	,	,
cord-334133-61om170g	228	28	1996	1996	CD
cord-334133-61om170g	228	29	)	)	-RRB-
cord-334133-61om170g	228	30	.	.	.
cord-334133-61om170g	229	1	Gp41	Gp41	NNP
cord-334133-61om170g	229	2	is	be	VBZ
cord-334133-61om170g	229	3	also	also	RB
cord-334133-61om170g	229	4	involved	involve	VBN
cord-334133-61om170g	229	5	in	in	IN
cord-334133-61om170g	229	6	basolateral	basolateral	JJ
cord-334133-61om170g	229	7	localization	localization	NN
cord-334133-61om170g	229	8	of	of	IN
cord-334133-61om170g	229	9	envelope	envelope	NN
cord-334133-61om170g	229	10	protein	protein	NN
cord-334133-61om170g	229	11	in	in	IN
cord-334133-61om170g	229	12	the	the	DT
cord-334133-61om170g	229	13	plasma	plasma	NN
cord-334133-61om170g	229	14	membrane	membrane	NN
cord-334133-61om170g	229	15	of	of	IN
cord-334133-61om170g	229	16	polarized	polarized	JJ
cord-334133-61om170g	229	17	cells	cell	NNS
cord-334133-61om170g	229	18	(	(	-LRB-
cord-334133-61om170g	229	19	Owens	Owens	NNP
cord-334133-61om170g	229	20	et	et	NNP
cord-334133-61om170g	229	21	al	al	NNP
cord-334133-61om170g	229	22	.	.	NNP
cord-334133-61om170g	229	23	,	,	,
cord-334133-61om170g	229	24	1991	1991	CD
cord-334133-61om170g	229	25	)	)	-RRB-
cord-334133-61om170g	229	26	,	,	,
cord-334133-61om170g	229	27	a	a	DT
cord-334133-61om170g	229	28	property	property	NN
cord-334133-61om170g	229	29	that	that	WDT
cord-334133-61om170g	229	30	is	be	VBZ
cord-334133-61om170g	229	31	lost	lose	VBN
cord-334133-61om170g	229	32	when	when	WRB
cord-334133-61om170g	229	33	the	the	DT
cord-334133-61om170g	229	34	tyrosine	tyrosine	NN
cord-334133-61om170g	229	35	of	of	IN
cord-334133-61om170g	229	36	the	the	DT
cord-334133-61om170g	229	37	first	first	JJ
cord-334133-61om170g	229	38	signal	signal	NN
cord-334133-61om170g	229	39	is	be	VBZ
cord-334133-61om170g	229	40	substituted	substitute	VBN
cord-334133-61om170g	229	41	(	(	-LRB-
cord-334133-61om170g	229	42	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	229	43	et	et	FW
cord-334133-61om170g	229	44	al	al	NNP
cord-334133-61om170g	229	45	.	.	NNP
cord-334133-61om170g	229	46	,	,	,
cord-334133-61om170g	229	47	1999	1999	CD
cord-334133-61om170g	229	48	;	;	:
cord-334133-61om170g	229	49	Lodge	Lodge	NNP
cord-334133-61om170g	229	50	et	et	NNP
cord-334133-61om170g	229	51	al	al	NNP
cord-334133-61om170g	229	52	.	.	NNP
cord-334133-61om170g	229	53	,	,	,
cord-334133-61om170g	229	54	1997	1997	CD
cord-334133-61om170g	229	55	)	)	-RRB-
cord-334133-61om170g	229	56	.	.	.
cord-334133-61om170g	230	1	In	in	IN
cord-334133-61om170g	230	2	the	the	DT
cord-334133-61om170g	230	3	1-MSD	1-msd	CD
cord-334133-61om170g	230	4	model	model	NN
cord-334133-61om170g	230	5	of	of	IN
cord-334133-61om170g	230	6	gp41	gp41	NNP
cord-334133-61om170g	230	7	,	,	,
cord-334133-61om170g	230	8	Gallaher	Gallaher	NNP
cord-334133-61om170g	230	9	et	et	IN
cord-334133-61om170g	230	10	al	al	NNP
cord-334133-61om170g	230	11	.	.	.
cord-334133-61om170g	231	1	(	(	-LRB-
cord-334133-61om170g	231	2	1989	1989	CD
cord-334133-61om170g	231	3	)	)	-RRB-
cord-334133-61om170g	231	4	have	have	VBP
cord-334133-61om170g	231	5	proposed	propose	VBN
cord-334133-61om170g	231	6	that	that	IN
cord-334133-61om170g	231	7	the	the	DT
cord-334133-61om170g	231	8	MSD	MSD	NNP
cord-334133-61om170g	231	9	ends	end	VBZ
cord-334133-61om170g	231	10	at	at	IN
cord-334133-61om170g	231	11	residue	residue	NN
cord-334133-61om170g	231	12	712	712	CD
cord-334133-61om170g	231	13	V	v	NN
cord-334133-61om170g	231	14	,	,	,
cord-334133-61om170g	231	15	and	and	CC
cord-334133-61om170g	231	16	thus	thus	RB
cord-334133-61om170g	231	17	719	719	CD
cord-334133-61om170g	231	18	Y	Y	NNP
cord-334133-61om170g	231	19	will	will	MD
cord-334133-61om170g	231	20	be	be	VB
cord-334133-61om170g	231	21	the	the	DT
cord-334133-61om170g	231	22	7th	7th	JJ
cord-334133-61om170g	231	23	residue	residue	NN
cord-334133-61om170g	231	24	from	from	IN
cord-334133-61om170g	231	25	the	the	DT
cord-334133-61om170g	231	26	membrane	membrane	NN
cord-334133-61om170g	231	27	,	,	,
cord-334133-61om170g	231	28	and	and	CC
cord-334133-61om170g	231	29	.	.	.
cord-334133-61om170g	232	1	Only	only	RB
cord-334133-61om170g	232	2	a	a	DT
cord-334133-61om170g	232	3	monomer	monomer	NN
cord-334133-61om170g	232	4	is	be	VBZ
cord-334133-61om170g	232	5	represented	represent	VBN
cord-334133-61om170g	232	6	.	.	.
cord-334133-61om170g	233	1	There	there	EX
cord-334133-61om170g	233	2	may	may	MD
cord-334133-61om170g	233	3	be	be	VB
cord-334133-61om170g	233	4	interactions	interaction	NNS
cord-334133-61om170g	233	5	between	between	IN
cord-334133-61om170g	233	6	MSD	MSD	NNP
cord-334133-61om170g	233	7	1	1	CD
cord-334133-61om170g	233	8	,	,	,
cord-334133-61om170g	233	9	2	2	CD
cord-334133-61om170g	233	10	,	,	,
cord-334133-61om170g	233	11	and	and	CC
cord-334133-61om170g	233	12	3	3	CD
cord-334133-61om170g	233	13	,	,	,
cord-334133-61om170g	233	14	between	between	IN
cord-334133-61om170g	233	15	the	the	DT
cord-334133-61om170g	233	16	minor	minor	JJ
cord-334133-61om170g	233	17	ectodomain	ectodomain	NN
cord-334133-61om170g	233	18	and	and	CC
cord-334133-61om170g	233	19	the	the	DT
cord-334133-61om170g	233	20	gp41	gp41	NNP
cord-334133-61om170g	233	21	major	major	JJ
cord-334133-61om170g	233	22	ectodomain	ectodomain	NN
cord-334133-61om170g	233	23	,	,	,
cord-334133-61om170g	233	24	between	between	IN
cord-334133-61om170g	233	25	the	the	DT
cord-334133-61om170g	233	26	minor	minor	JJ
cord-334133-61om170g	233	27	ectodomain	ectodomain	NN
cord-334133-61om170g	233	28	and	and	CC
cord-334133-61om170g	233	29	elements	element	NNS
cord-334133-61om170g	233	30	of	of	IN
cord-334133-61om170g	233	31	gp120	gp120	NNP
cord-334133-61om170g	233	32	,	,	,
cord-334133-61om170g	233	33	or	or	CC
cord-334133-61om170g	233	34	with	with	IN
cord-334133-61om170g	233	35	the	the	DT
cord-334133-61om170g	233	36	other	other	JJ
cord-334133-61om170g	233	37	gp41	gp41	NNP
cord-334133-61om170g	233	38	monomers	monomer	NNS
cord-334133-61om170g	233	39	that	that	WDT
cord-334133-61om170g	233	40	form	form	VBP
cord-334133-61om170g	233	41	the	the	DT
cord-334133-61om170g	233	42	trimer	trimer	NN
cord-334133-61om170g	233	43	(	(	-LRB-
cord-334133-61om170g	233	44	arrows	arrow	NNS
cord-334133-61om170g	233	45	)	)	-RRB-
cord-334133-61om170g	233	46	.	.	.
cord-334133-61om170g	234	1	The	the	DT
cord-334133-61om170g	234	2	nine	nine	CD
cord-334133-61om170g	234	3	MSDs	msd	NNS
cord-334133-61om170g	234	4	of	of	IN
cord-334133-61om170g	234	5	the	the	DT
cord-334133-61om170g	234	6	trimer	trimer	NN
cord-334133-61om170g	234	7	could	could	MD
cord-334133-61om170g	234	8	also	also	RB
cord-334133-61om170g	234	9	interact	interact	VB
cord-334133-61om170g	234	10	with	with	IN
cord-334133-61om170g	234	11	each	each	DT
cord-334133-61om170g	234	12	other	other	JJ
cord-334133-61om170g	234	13	.	.	.
cord-334133-61om170g	235	1	The	the	DT
cord-334133-61om170g	235	2	antigenically	antigenically	RB
cord-334133-61om170g	235	3	active	active	JJ
cord-334133-61om170g	235	4	Kennedy	Kennedy	NNP
cord-334133-61om170g	235	5	sequence	sequence	NN
cord-334133-61om170g	235	6	(	(	-LRB-
cord-334133-61om170g	235	7	731	731	CD
cord-334133-61om170g	235	8	-752	-752	NNS
cord-334133-61om170g	235	9	)	)	-RRB-
cord-334133-61om170g	235	10	containing	contain	VBG
cord-334133-61om170g	235	11	neutralizing	neutralize	VBG
cord-334133-61om170g	235	12	and	and	CC
cord-334133-61om170g	235	13	non	non	JJ
cord-334133-61om170g	235	14	-	-	JJ
cord-334133-61om170g	235	15	neutralizing	neutralizing	JJ
cord-334133-61om170g	235	16	epitopes	epitope	NNS
cord-334133-61om170g	235	17	is	be	VBZ
cord-334133-61om170g	235	18	shown	show	VBN
cord-334133-61om170g	235	19	as	as	IN
cord-334133-61om170g	235	20	the	the	DT
cord-334133-61om170g	235	21	outer	outer	JJ
cord-334133-61om170g	235	22	face	face	NN
cord-334133-61om170g	235	23	of	of	IN
cord-334133-61om170g	235	24	the	the	DT
cord-334133-61om170g	235	25	minor	minor	JJ
cord-334133-61om170g	235	26	ectodomain	ectodomain	NN
cord-334133-61om170g	235	27	.	.	.
cord-334133-61om170g	236	1	Table	table	NN
cord-334133-61om170g	236	2	1	1	CD
cord-334133-61om170g	236	3	Predicted	predict	VBN
cord-334133-61om170g	236	4	location	location	NN
cord-334133-61om170g	236	5	of	of	IN
cord-334133-61om170g	236	6	residues	residue	NNS
cord-334133-61om170g	236	7	in	in	IN
cord-334133-61om170g	236	8	the	the	DT
cord-334133-61om170g	236	9	3-MSD	3-msd	CD
cord-334133-61om170g	236	10	conformation	conformation	NN
cord-334133-61om170g	236	11	of	of	IN
cord-334133-61om170g	236	12	the	the	DT
cord-334133-61om170g	236	13	gp41	gp41	NN
cord-334133-61om170g	236	14	of	of	IN
cord-334133-61om170g	236	15	HIV-1	HIV-1	NNP
cord-334133-61om170g	236	16	clades	clade	NNS
cord-334133-61om170g	236	17	A	a	DT
cord-334133-61om170g	236	18	to	to	IN
cord-334133-61om170g	236	19	D	d	NN
cord-334133-61om170g	236	20	in	in	IN
cord-334133-61om170g	236	21	the	the	DT
cord-334133-61om170g	236	22	virion	virion	NN
cord-334133-61om170g	236	23	or	or	CC
cord-334133-61om170g	236	24	cell	cell	NN
cord-334133-61om170g	236	25	membrane	membrane	NN
cord-334133-61om170g	236	26	within	within	IN
cord-334133-61om170g	236	27	the	the	DT
cord-334133-61om170g	236	28	required	require	VBN
cord-334133-61om170g	236	29	distance	distance	NN
cord-334133-61om170g	236	30	for	for	IN
cord-334133-61om170g	236	31	optimum	optimum	JJ
cord-334133-61om170g	236	32	function	function	NN
cord-334133-61om170g	236	33	.	.	.
cord-334133-61om170g	237	1	Much	much	JJ
cord-334133-61om170g	237	2	depends	depend	VBZ
cord-334133-61om170g	237	3	on	on	IN
cord-334133-61om170g	237	4	knowing	know	VBG
cord-334133-61om170g	237	5	precisely	precisely	RB
cord-334133-61om170g	237	6	which	which	WDT
cord-334133-61om170g	237	7	residue	residue	NN
cord-334133-61om170g	237	8	ends	end	VBZ
cord-334133-61om170g	237	9	the	the	DT
cord-334133-61om170g	237	10	MSD	MSD	NNP
cord-334133-61om170g	237	11	.	.	.
cord-334133-61om170g	238	1	Often	often	RB
cord-334133-61om170g	238	2	a	a	DT
cord-334133-61om170g	238	3	charged	charge	VBN
cord-334133-61om170g	238	4	residue	residue	NN
cord-334133-61om170g	238	5	that	that	WDT
cord-334133-61om170g	238	6	acts	act	VBZ
cord-334133-61om170g	238	7	as	as	IN
cord-334133-61om170g	238	8	a	a	DT
cord-334133-61om170g	238	9	stopper	stopper	NN
cord-334133-61om170g	238	10	defines	define	VBZ
cord-334133-61om170g	238	11	the	the	DT
cord-334133-61om170g	238	12	end	end	NN
cord-334133-61om170g	238	13	,	,	,
cord-334133-61om170g	238	14	and	and	CC
cord-334133-61om170g	238	15	it	-PRON-	PRP
cord-334133-61om170g	238	16	is	be	VBZ
cord-334133-61om170g	238	17	possible	possible	JJ
cord-334133-61om170g	238	18	that	that	IN
cord-334133-61om170g	238	19	the	the	DT
cord-334133-61om170g	238	20	gp41	gp41	NN
cord-334133-61om170g	238	21	MSD	MSD	NNP
cord-334133-61om170g	238	22	could	could	MD
cord-334133-61om170g	238	23	end	end	VB
cord-334133-61om170g	238	24	at	at	IN
cord-334133-61om170g	238	25	714	714	NNP
cord-334133-61om170g	238	26	R.	R.	NNP
cord-334133-61om170g	239	1	If	if	IN
cord-334133-61om170g	239	2	so	so	RB
cord-334133-61om170g	239	3	,	,	,
cord-334133-61om170g	239	4	719	719	CD
cord-334133-61om170g	239	5	Y	Y	NNP
cord-334133-61om170g	239	6	would	would	MD
cord-334133-61om170g	239	7	be	be	VB
cord-334133-61om170g	239	8	5	5	CD
cord-334133-61om170g	239	9	residues	residue	NNS
cord-334133-61om170g	239	10	from	from	IN
cord-334133-61om170g	239	11	the	the	DT
cord-334133-61om170g	239	12	membrane	membrane	NN
cord-334133-61om170g	239	13	,	,	,
cord-334133-61om170g	239	14	and	and	CC
cord-334133-61om170g	239	15	this	this	DT
cord-334133-61om170g	239	16	might	may	MD
cord-334133-61om170g	239	17	compromise	compromise	VB
cord-334133-61om170g	239	18	the	the	DT
cord-334133-61om170g	239	19	endocytosis	endocytosis	NN
cord-334133-61om170g	239	20	,	,	,
cord-334133-61om170g	239	21	basolateral	basolateral	JJ
cord-334133-61om170g	239	22	sorting	sorting	NN
cord-334133-61om170g	239	23	,	,	,
cord-334133-61om170g	239	24	and	and	CC
cord-334133-61om170g	239	25	lysosomal	lysosomal	JJ
cord-334133-61om170g	239	26	targeting	targeting	NN
cord-334133-61om170g	239	27	functions	function	NNS
cord-334133-61om170g	239	28	of	of	IN
cord-334133-61om170g	239	29	the	the	DT
cord-334133-61om170g	239	30	signal	signal	NN
cord-334133-61om170g	239	31	.	.	.
cord-334133-61om170g	240	1	The	the	DT
cord-334133-61om170g	240	2	minimum	minimum	JJ
cord-334133-61om170g	240	3	distance	distance	NN
cord-334133-61om170g	240	4	of	of	IN
cord-334133-61om170g	240	5	the	the	DT
cord-334133-61om170g	240	6	tyrosine	tyrosine	NN
cord-334133-61om170g	240	7	-	-	HYPH
cord-334133-61om170g	240	8	signal	signal	NN
cord-334133-61om170g	240	9	from	from	IN
cord-334133-61om170g	240	10	the	the	DT
cord-334133-61om170g	240	11	membrane	membrane	NN
cord-334133-61om170g	240	12	is	be	VBZ
cord-334133-61om170g	240	13	required	require	VBN
cord-334133-61om170g	240	14	for	for	IN
cord-334133-61om170g	240	15	both	both	DT
cord-334133-61om170g	240	16	direct	direct	JJ
cord-334133-61om170g	240	17	lysosomal	lysosomal	NN
cord-334133-61om170g	240	18	targeting	targeting	NN
cord-334133-61om170g	240	19	and	and	CC
cord-334133-61om170g	240	20	endocytosis	endocytosis	NN
cord-334133-61om170g	241	1	(	(	-LRB-
cord-334133-61om170g	241	2	Collawn	Collawn	NNP
cord-334133-61om170g	241	3	et	et	NNP
cord-334133-61om170g	241	4	al	al	NNP
cord-334133-61om170g	241	5	.	.	NNP
cord-334133-61om170g	241	6	,	,	,
cord-334133-61om170g	241	7	1990	1990	CD
cord-334133-61om170g	242	1	;	;	:
cord-334133-61om170g	242	2	Pytowski	Pytowski	NNP
cord-334133-61om170g	242	3	et	et	NNP
cord-334133-61om170g	242	4	al	al	NNP
cord-334133-61om170g	242	5	.	.	NNP
cord-334133-61om170g	242	6	,	,	,
cord-334133-61om170g	242	7	1995	1995	CD
cord-334133-61om170g	242	8	;	;	:
cord-334133-61om170g	243	1	Trowbridge	Trowbridge	NNP
cord-334133-61om170g	243	2	and	and	CC
cord-334133-61om170g	243	3	Collawn	Collawn	NNP
cord-334133-61om170g	243	4	,	,	,
cord-334133-61om170g	243	5	1992	1992	CD
cord-334133-61om170g	243	6	;	;	:
cord-334133-61om170g	243	7	Trowbridge	Trowbridge	NNP
cord-334133-61om170g	243	8	et	et	NNP
cord-334133-61om170g	243	9	al	al	NNP
cord-334133-61om170g	243	10	.	.	NNP
cord-334133-61om170g	243	11	,	,	,
cord-334133-61om170g	243	12	1993	1993	CD
cord-334133-61om170g	243	13	)	)	-RRB-
cord-334133-61om170g	243	14	.	.	.
cord-334133-61om170g	244	1	However	however	RB
cord-334133-61om170g	244	2	,	,	,
cord-334133-61om170g	244	3	only	only	RB
cord-334133-61om170g	244	4	lysosomal	lysosomal	JJ
cord-334133-61om170g	244	5	targeting	targeting	NN
cord-334133-61om170g	244	6	signals	signal	NNS
cord-334133-61om170g	244	7	have	have	VBP
cord-334133-61om170g	244	8	a	a	DT
cord-334133-61om170g	244	9	strict	strict	JJ
cord-334133-61om170g	244	10	maximum	maximum	JJ
cord-334133-61om170g	244	11	distance	distance	NN
cord-334133-61om170g	244	12	from	from	IN
cord-334133-61om170g	244	13	the	the	DT
cord-334133-61om170g	244	14	membrane	membrane	NN
cord-334133-61om170g	244	15	(	(	-LRB-
cord-334133-61om170g	244	16	Collawn	Collawn	NNP
cord-334133-61om170g	244	17	,	,	,
cord-334133-61om170g	244	18	1990	1990	CD
cord-334133-61om170g	244	19	;	;	:
cord-334133-61om170g	244	20	Rohrer	Rohrer	NNP
cord-334133-61om170g	244	21	et	et	NNP
cord-334133-61om170g	244	22	al	al	NNP
cord-334133-61om170g	244	23	.	.	.
cord-334133-61om170g	245	1	,	,	,
cord-334133-61om170g	245	2	1996	1996	CD
cord-334133-61om170g	245	3	;	;	:
cord-334133-61om170g	245	4	Trowbridge	Trowbridge	NNP
cord-334133-61om170g	245	5	and	and	CC
cord-334133-61om170g	245	6	Collawn	Collawn	NNP
cord-334133-61om170g	245	7	,	,	,
cord-334133-61om170g	245	8	1992	1992	CD
cord-334133-61om170g	245	9	;	;	:
cord-334133-61om170g	245	10	Trowbridge	Trowbridge	NNP
cord-334133-61om170g	245	11	et	et	NNP
cord-334133-61om170g	245	12	al	al	NNP
cord-334133-61om170g	245	13	.	.	NNP
cord-334133-61om170g	245	14	,	,	,
cord-334133-61om170g	245	15	1993	1993	CD
cord-334133-61om170g	245	16	)	)	-RRB-
cord-334133-61om170g	245	17	.	.	.
cord-334133-61om170g	246	1	The	the	DT
cord-334133-61om170g	246	2	fact	fact	NN
cord-334133-61om170g	246	3	that	that	IN
cord-334133-61om170g	246	4	the	the	DT
cord-334133-61om170g	246	5	first	first	JJ
cord-334133-61om170g	246	6	tyrosine	tyrosine	NN
cord-334133-61om170g	246	7	signal	signal	NN
cord-334133-61om170g	246	8	functions	function	NNS
cord-334133-61om170g	246	9	in	in	IN
cord-334133-61om170g	246	10	endocytosis	endocytosis	NN
cord-334133-61om170g	246	11	(	(	-LRB-
cord-334133-61om170g	246	12	as	as	IN
cord-334133-61om170g	246	13	referenced	reference	VBN
cord-334133-61om170g	246	14	above	above	RB
cord-334133-61om170g	246	15	)	)	-RRB-
cord-334133-61om170g	246	16	argues	argue	VBZ
cord-334133-61om170g	246	17	that	that	IN
cord-334133-61om170g	246	18	it	-PRON-	PRP
cord-334133-61om170g	246	19	is	be	VBZ
cord-334133-61om170g	246	20	indeed	indeed	RB
cord-334133-61om170g	246	21	at	at	IN
cord-334133-61om170g	246	22	the	the	DT
cord-334133-61om170g	246	23	required	require	VBN
cord-334133-61om170g	246	24	distance	distance	NN
cord-334133-61om170g	246	25	from	from	IN
cord-334133-61om170g	246	26	the	the	DT
cord-334133-61om170g	246	27	membrane	membrane	NN
cord-334133-61om170g	246	28	,	,	,
cord-334133-61om170g	246	29	but	but	CC
cord-334133-61om170g	246	30	at	at	IN
cord-334133-61om170g	246	31	the	the	DT
cord-334133-61om170g	246	32	time	time	NN
cord-334133-61om170g	246	33	of	of	IN
cord-334133-61om170g	246	34	writing	writing	NN
cord-334133-61om170g	246	35	there	there	EX
cord-334133-61om170g	246	36	are	be	VBP
cord-334133-61om170g	246	37	no	no	DT
cord-334133-61om170g	246	38	experimental	experimental	JJ
cord-334133-61om170g	246	39	data	datum	NNS
cord-334133-61om170g	246	40	to	to	TO
cord-334133-61om170g	246	41	show	show	VB
cord-334133-61om170g	246	42	if	if	IN
cord-334133-61om170g	246	43	the	the	DT
cord-334133-61om170g	246	44	signal	signal	NN
cord-334133-61om170g	246	45	is	be	VBZ
cord-334133-61om170g	246	46	active	active	JJ
cord-334133-61om170g	246	47	in	in	IN
cord-334133-61om170g	246	48	directing	direct	VBG
cord-334133-61om170g	246	49	gp41	gp41	NN
cord-334133-61om170g	246	50	to	to	IN
cord-334133-61om170g	246	51	lysosomes	lysosome	NNS
cord-334133-61om170g	246	52	.	.	.
cord-334133-61om170g	247	1	The	the	DT
cord-334133-61om170g	247	2	3-MSD	3-msd	CD
cord-334133-61om170g	247	3	model	model	NN
cord-334133-61om170g	247	4	,	,	,
cord-334133-61om170g	247	5	as	as	IN
cord-334133-61om170g	247	6	stated	state	VBN
cord-334133-61om170g	247	7	above	above	RB
cord-334133-61om170g	247	8	,	,	,
cord-334133-61om170g	247	9	puts	put	VBZ
cord-334133-61om170g	247	10	the	the	DT
cord-334133-61om170g	247	11	first	first	JJ
cord-334133-61om170g	247	12	tyrosine	tyrosine	NN
cord-334133-61om170g	247	13	signal	signal	NN
cord-334133-61om170g	247	14	outside	outside	IN
cord-334133-61om170g	247	15	the	the	DT
cord-334133-61om170g	247	16	membrane	membrane	NN
cord-334133-61om170g	247	17	where	where	WRB
cord-334133-61om170g	247	18	it	-PRON-	PRP
cord-334133-61om170g	247	19	is	be	VBZ
cord-334133-61om170g	247	20	non	non	JJ
cord-334133-61om170g	247	21	-	-	JJ
cord-334133-61om170g	247	22	functional	functional	JJ
cord-334133-61om170g	247	23	for	for	IN
cord-334133-61om170g	247	24	any	any	DT
cord-334133-61om170g	247	25	transport	transport	NN
cord-334133-61om170g	247	26	function	function	NN
cord-334133-61om170g	248	1	(	(	-LRB-
cord-334133-61om170g	248	2	Fig	Fig	NNP
cord-334133-61om170g	248	3	.	.	NNP
cord-334133-61om170g	248	4	5	5	CD
cord-334133-61om170g	248	5	)	)	-RRB-
cord-334133-61om170g	248	6	.	.	.
cord-334133-61om170g	249	1	Adaptor	adaptor	NN
cord-334133-61om170g	249	2	protein	protein	NN
cord-334133-61om170g	249	3	(	(	-LRB-
cord-334133-61om170g	249	4	AP	AP	NNP
cord-334133-61om170g	249	5	)	)	-RRB-
cord-334133-61om170g	249	6	complexes	complex	NNS
cord-334133-61om170g	249	7	interact	interact	VBP
cord-334133-61om170g	249	8	with	with	IN
cord-334133-61om170g	249	9	tyrosinesorting	tyrosinesorting	NN
cord-334133-61om170g	249	10	signals	signal	NNS
cord-334133-61om170g	249	11	.	.	.
cord-334133-61om170g	250	1	AP-1	AP-1	NNP
cord-334133-61om170g	251	1	and	and	CC
cord-334133-61om170g	251	2	AP-3	AP-3	NNP
cord-334133-61om170g	251	3	complexes	complex	NNS
cord-334133-61om170g	251	4	are	be	VBP
cord-334133-61om170g	251	5	mainly	mainly	RB
cord-334133-61om170g	251	6	found	find	VBN
cord-334133-61om170g	251	7	in	in	IN
cord-334133-61om170g	251	8	the	the	DT
cord-334133-61om170g	251	9	TGN	TGN	NNP
cord-334133-61om170g	251	10	and	and	CC
cord-334133-61om170g	251	11	function	function	NN
cord-334133-61om170g	251	12	in	in	IN
cord-334133-61om170g	251	13	lysosomal	lysosomal	JJ
cord-334133-61om170g	251	14	targeting	targeting	NN
cord-334133-61om170g	251	15	,	,	,
cord-334133-61om170g	251	16	while	while	IN
cord-334133-61om170g	251	17	AP-2	AP-2	NNP
cord-334133-61om170g	251	18	is	be	VBZ
cord-334133-61om170g	251	19	predominantly	predominantly	RB
cord-334133-61om170g	251	20	localized	localize	VBN
cord-334133-61om170g	251	21	to	to	IN
cord-334133-61om170g	251	22	the	the	DT
cord-334133-61om170g	251	23	plasma	plasma	NN
cord-334133-61om170g	251	24	membrane	membrane	NN
cord-334133-61om170g	251	25	and	and	CC
cord-334133-61om170g	251	26	functions	function	NNS
cord-334133-61om170g	251	27	in	in	IN
cord-334133-61om170g	251	28	endocytosis	endocytosis	NN
cord-334133-61om170g	251	29	.	.	.
cord-334133-61om170g	252	1	They	-PRON-	PRP
cord-334133-61om170g	252	2	have	have	VBP
cord-334133-61om170g	252	3	distinct	distinct	JJ
cord-334133-61om170g	252	4	preferences	preference	NNS
cord-334133-61om170g	252	5	for	for	IN
cord-334133-61om170g	252	6	specific	specific	JJ
cord-334133-61om170g	252	7	residues	residue	NNS
cord-334133-61om170g	252	8	or	or	CC
cord-334133-61om170g	252	9	combinations	combination	NNS
cord-334133-61om170g	252	10	of	of	IN
cord-334133-61om170g	252	11	residues	residue	NNS
cord-334133-61om170g	252	12	of	of	IN
cord-334133-61om170g	252	13	the	the	DT
cord-334133-61om170g	252	14	tyrosine	tyrosine	NN
cord-334133-61om170g	252	15	signals	signal	NNS
cord-334133-61om170g	252	16	,	,	,
cord-334133-61om170g	252	17	although	although	IN
cord-334133-61om170g	252	18	there	there	EX
cord-334133-61om170g	252	19	is	be	VBZ
cord-334133-61om170g	252	20	overlap	overlap	NN
cord-334133-61om170g	252	21	,	,	,
cord-334133-61om170g	252	22	particularly	particularly	RB
cord-334133-61om170g	252	23	with	with	IN
cord-334133-61om170g	252	24	AP-1	AP-1	NNP
cord-334133-61om170g	252	25	and	and	CC
cord-334133-61om170g	252	26	AP-3	AP-3	NNP
cord-334133-61om170g	252	27	complexes	complex	NNS
cord-334133-61om170g	252	28	(	(	-LRB-
cord-334133-61om170g	252	29	Table	table	NN
cord-334133-61om170g	252	30	2	2	CD
cord-334133-61om170g	252	31	)	)	-RRB-
cord-334133-61om170g	253	1	(	(	-LRB-
cord-334133-61om170g	253	2	Boll	Boll	NNP
cord-334133-61om170g	253	3	et	et	NNP
cord-334133-61om170g	253	4	al	al	NNP
cord-334133-61om170g	253	5	.	.	.
cord-334133-61om170g	254	1	,	,	,
cord-334133-61om170g	254	2	1996	1996	CD
cord-334133-61om170g	254	3	;	;	:
cord-334133-61om170g	254	4	Ohno	Ohno	NNP
cord-334133-61om170g	254	5	et	et	NNP
cord-334133-61om170g	254	6	al	al	NNP
cord-334133-61om170g	254	7	.	.	.
cord-334133-61om170g	255	1	,	,	,
cord-334133-61om170g	255	2	1996	1996	CD
cord-334133-61om170g	256	1	Ohno	Ohno	NNP
cord-334133-61om170g	256	2	et	et	NNP
cord-334133-61om170g	256	3	al	al	NNP
cord-334133-61om170g	256	4	.	.	NNP
cord-334133-61om170g	256	5	,	,	,
cord-334133-61om170g	256	6	,	,	,
cord-334133-61om170g	256	7	1998	1998	CD
cord-334133-61om170g	256	8	.	.	.
cord-334133-61om170g	257	1	Table	table	NN
cord-334133-61om170g	257	2	2	2	CD
cord-334133-61om170g	257	3	shows	show	VBZ
cord-334133-61om170g	257	4	that	that	IN
cord-334133-61om170g	257	5	the	the	DT
cord-334133-61om170g	257	6	consensus	consensus	NN
cord-334133-61om170g	257	7	sequence	sequence	NN
cord-334133-61om170g	257	8	of	of	IN
cord-334133-61om170g	257	9	the	the	DT
cord-334133-61om170g	257	10	first	first	JJ
cord-334133-61om170g	257	11	tyrosine	tyrosine	NN
cord-334133-61om170g	257	12	-	-	HYPH
cord-334133-61om170g	257	13	sorting	sort	VBG
cord-334133-61om170g	257	14	signal	signal	NN
cord-334133-61om170g	257	15	of	of	IN
cord-334133-61om170g	257	16	the	the	DT
cord-334133-61om170g	257	17	gp41	gp41	NNP
cord-334133-61om170g	257	18	tail	tail	NN
cord-334133-61om170g	257	19	of	of	IN
cord-334133-61om170g	257	20	clades	clade	NNS
cord-334133-61om170g	257	21	A	a	VBP
cord-334133-61om170g	257	22	to	to	IN
cord-334133-61om170g	257	23	D	D	NNP
cord-334133-61om170g	257	24	most	most	RBS
cord-334133-61om170g	257	25	closely	closely	RB
cord-334133-61om170g	257	26	matches	match	VBZ
cord-334133-61om170g	257	27	the	the	DT
cord-334133-61om170g	257	28	preferences	preference	NNS
cord-334133-61om170g	257	29	of	of	IN
cord-334133-61om170g	257	30	AP-1	AP-1	NNP
cord-334133-61om170g	257	31	and	and	CC
cord-334133-61om170g	257	32	AP-3	AP-3	NNP
cord-334133-61om170g	257	33	complexes	complex	NNS
cord-334133-61om170g	257	34	.	.	.
cord-334133-61om170g	258	1	The	the	DT
cord-334133-61om170g	258	2	arginine	arginine	NN
cord-334133-61om170g	258	3	residue	residue	NN
cord-334133-61om170g	258	4	at	at	IN
cord-334133-61om170g	258	5	position	position	NN
cord-334133-61om170g	258	6	Y	Y	NNP
cord-334133-61om170g	258	7	À	À	NNP
cord-334133-61om170g	258	8	3	3	CD
cord-334133-61om170g	258	9	of	of	IN
cord-334133-61om170g	258	10	the	the	DT
cord-334133-61om170g	258	11	signal	signal	NN
cord-334133-61om170g	258	12	is	be	VBZ
cord-334133-61om170g	258	13	100	100	CD
cord-334133-61om170g	258	14	%	%	NN
cord-334133-61om170g	258	15	conserved	conserved	JJ
cord-334133-61om170g	258	16	,	,	,
cord-334133-61om170g	258	17	and	and	CC
cord-334133-61om170g	258	18	there	there	EX
cord-334133-61om170g	258	19	is	be	VBZ
cord-334133-61om170g	258	20	almost	almost	RB
cord-334133-61om170g	258	21	complete	complete	JJ
cord-334133-61om170g	258	22	conservation	conservation	NN
cord-334133-61om170g	258	23	of	of	IN
cord-334133-61om170g	258	24	the	the	DT
cord-334133-61om170g	258	25	glycine	glycine	NN
cord-334133-61om170g	258	26	at	at	IN
cord-334133-61om170g	258	27	Y	Y	NNP
cord-334133-61om170g	258	28	À	à	NN
cord-334133-61om170g	258	29	1	1	CD
cord-334133-61om170g	258	30	(	(	-LRB-
cord-334133-61om170g	258	31	99.95	99.95	CD
cord-334133-61om170g	258	32	%	%	NN
cord-334133-61om170g	258	33	)	)	-RRB-
cord-334133-61om170g	258	34	,	,	,
cord-334133-61om170g	258	35	the	the	DT
cord-334133-61om170g	258	36	tyrosine	tyrosine	NN
cord-334133-61om170g	258	37	itself	-PRON-	PRP
cord-334133-61om170g	258	38	(	(	-LRB-
cord-334133-61om170g	258	39	99.7	99.7	CD
cord-334133-61om170g	258	40	%	%	NN
cord-334133-61om170g	258	41	)	)	-RRB-
cord-334133-61om170g	258	42	,	,	,
cord-334133-61om170g	258	43	and	and	CC
cord-334133-61om170g	258	44	the	the	DT
cord-334133-61om170g	258	45	proline	proline	NN
cord-334133-61om170g	258	46	at	at	IN
cord-334133-61om170g	258	47	Y	Y	NNP
cord-334133-61om170g	259	1	+	+	SYM
cord-334133-61om170g	259	2	2	2	CD
cord-334133-61om170g	259	3	(	(	-LRB-
cord-334133-61om170g	259	4	99.8	99.8	CD
cord-334133-61om170g	259	5	%	%	NN
cord-334133-61om170g	259	6	)	)	-RRB-
cord-334133-61om170g	259	7	.	.	.
cord-334133-61om170g	260	1	The	the	DT
cord-334133-61om170g	260	2	leucine	leucine	NN
cord-334133-61om170g	260	3	residue	residue	NN
cord-334133-61om170g	260	4	at	at	IN
cord-334133-61om170g	260	5	Y	Y	NNP
cord-334133-61om170g	260	6	+	+	CC
cord-334133-61om170g	260	7	3	3	CD
cord-334133-61om170g	260	8	is	be	VBZ
cord-334133-61om170g	260	9	96.9	96.9	CD
cord-334133-61om170g	260	10	%	%	NN
cord-334133-61om170g	260	11	conserved	conserve	VBN
cord-334133-61om170g	260	12	,	,	,
cord-334133-61om170g	260	13	but	but	CC
cord-334133-61om170g	261	1	if	if	IN
cord-334133-61om170g	261	2	leucine	leucine	NN
cord-334133-61om170g	261	3	,	,	,
cord-334133-61om170g	261	4	isoleucine	isoleucine	NN
cord-334133-61om170g	261	5	,	,	,
cord-334133-61om170g	261	6	and	and	CC
cord-334133-61om170g	261	7	valine	valine	NN
cord-334133-61om170g	261	8	at	at	IN
cord-334133-61om170g	261	9	Y	Y	NNP
cord-334133-61om170g	261	10	+	+	CC
cord-334133-61om170g	261	11	3	3	CD
cord-334133-61om170g	262	1	(	(	-LRB-
cord-334133-61om170g	262	2	all	all	DT
cord-334133-61om170g	262	3	with	with	IN
cord-334133-61om170g	262	4	similar	similar	JJ
cord-334133-61om170g	262	5	properties	property	NNS
cord-334133-61om170g	262	6	and	and	CC
cord-334133-61om170g	262	7	tolerated	tolerate	VBD
cord-334133-61om170g	262	8	at	at	IN
cord-334133-61om170g	262	9	this	this	DT
cord-334133-61om170g	262	10	position	position	NN
cord-334133-61om170g	262	11	of	of	IN
cord-334133-61om170g	262	12	the	the	DT
cord-334133-61om170g	262	13	tyrosine	tyrosine	NN
cord-334133-61om170g	262	14	signal	signal	NN
cord-334133-61om170g	262	15	)	)	-RRB-
cord-334133-61om170g	262	16	are	be	VBP
cord-334133-61om170g	262	17	summed	sum	VBN
cord-334133-61om170g	262	18	,	,	,
cord-334133-61om170g	262	19	conservation	conservation	NN
cord-334133-61om170g	262	20	reaches	reach	VBZ
cord-334133-61om170g	262	21	98.4	98.4	CD
cord-334133-61om170g	262	22	%	%	NN
cord-334133-61om170g	262	23	.	.	.
cord-334133-61om170g	263	1	Thus	thus	RB
cord-334133-61om170g	263	2	,	,	,
cord-334133-61om170g	263	3	the	the	DT
cord-334133-61om170g	263	4	first	first	JJ
cord-334133-61om170g	263	5	tyrosine	tyrosine	NN
cord-334133-61om170g	263	6	-	-	HYPH
cord-334133-61om170g	263	7	sorting	sort	VBG
cord-334133-61om170g	263	8	signal	signal	NN
cord-334133-61om170g	263	9	(	(	-LRB-
cord-334133-61om170g	263	10	719	719	CD
cord-334133-61om170g	263	11	YSPL	YSPL	NNP
cord-334133-61om170g	263	12	722	722	CD
cord-334133-61om170g	263	13	)	)	-RRB-
cord-334133-61om170g	263	14	could	could	MD
cord-334133-61om170g	263	15	interact	interact	VB
cord-334133-61om170g	263	16	with	with	IN
cord-334133-61om170g	263	17	the	the	DT
cord-334133-61om170g	263	18	AP-1	AP-1	NNP
cord-334133-61om170g	263	19	and	and	CC
cord-334133-61om170g	263	20	AP-3	AP-3	NNP
cord-334133-61om170g	263	21	complexes	complex	NNS
cord-334133-61om170g	263	22	in	in	IN
cord-334133-61om170g	263	23	the	the	DT
cord-334133-61om170g	263	24	TGN	TGN	NNP
cord-334133-61om170g	263	25	and	and	CC
cord-334133-61om170g	263	26	target	target	NN
cord-334133-61om170g	263	27	gp41	gp41	NNP
cord-334133-61om170g	263	28	to	to	IN
cord-334133-61om170g	263	29	the	the	DT
cord-334133-61om170g	263	30	lysosomes	lysosome	NNS
cord-334133-61om170g	263	31	.	.	.
cord-334133-61om170g	264	1	However	however	RB
cord-334133-61om170g	264	2	,	,	,
cord-334133-61om170g	264	3	as	as	IN
cord-334133-61om170g	264	4	stated	state	VBN
cord-334133-61om170g	264	5	above	above	RB
cord-334133-61om170g	264	6	,	,	,
cord-334133-61om170g	264	7	this	this	DT
cord-334133-61om170g	264	8	signal	signal	NN
cord-334133-61om170g	264	9	functions	function	NNS
cord-334133-61om170g	264	10	at	at	IN
cord-334133-61om170g	264	11	the	the	DT
cord-334133-61om170g	264	12	plasma	plasma	NN
cord-334133-61om170g	264	13	membrane	membrane	NN
cord-334133-61om170g	264	14	(	(	-LRB-
cord-334133-61om170g	264	15	Berlioz	Berlioz	NNP
cord-334133-61om170g	264	16	-	-	HYPH
cord-334133-61om170g	264	17	Torrent	Torrent	NNP
cord-334133-61om170g	264	18	et	et	FW
cord-334133-61om170g	264	19	al	al	NNP
cord-334133-61om170g	264	20	.	.	NNP
cord-334133-61om170g	264	21	,	,	,
cord-334133-61om170g	264	22	1999	1999	CD
cord-334133-61om170g	264	23	;	;	:
cord-334133-61om170g	264	24	Boge	Boge	NNP
cord-334133-61om170g	264	25	et	et	NNP
cord-334133-61om170g	264	26	al	al	NNP
cord-334133-61om170g	264	27	.	.	NNP
cord-334133-61om170g	264	28	,	,	,
cord-334133-61om170g	264	29	1998	1998	CD
cord-334133-61om170g	264	30	;	;	:
cord-334133-61om170g	264	31	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	264	32	et	et	FW
cord-334133-61om170g	264	33	al	al	NNP
cord-334133-61om170g	264	34	.	.	NNP
cord-334133-61om170g	264	35	,	,	,
cord-334133-61om170g	264	36	1999	1999	CD
cord-334133-61om170g	264	37	;	;	:
cord-334133-61om170g	264	38	Egan	Egan	NNP
cord-334133-61om170g	264	39	et	et	NNP
cord-334133-61om170g	264	40	al	al	NNP
cord-334133-61om170g	264	41	.	.	NNP
cord-334133-61om170g	264	42	,	,	,
cord-334133-61om170g	264	43	1996	1996	CD
cord-334133-61om170g	264	44	;	;	:
cord-334133-61om170g	264	45	Ohno	Ohno	NNP
cord-334133-61om170g	264	46	et	et	NNP
cord-334133-61om170g	264	47	al	al	NNP
cord-334133-61om170g	264	48	.	.	NNP
cord-334133-61om170g	264	49	,	,	,
cord-334133-61om170g	264	50	1997	1997	CD
cord-334133-61om170g	264	51	;	;	:
cord-334133-61om170g	264	52	Rowell	Rowell	NNP
cord-334133-61om170g	264	53	et	et	NNP
cord-334133-61om170g	264	54	al	al	NNP
cord-334133-61om170g	264	55	.	.	NNP
cord-334133-61om170g	264	56	,	,	,
cord-334133-61om170g	264	57	1995	1995	CD
cord-334133-61om170g	265	1	;	;	:
cord-334133-61om170g	265	2	West	West	NNP
cord-334133-61om170g	265	3	et	et	NNP
cord-334133-61om170g	265	4	al	al	NNP
cord-334133-61om170g	265	5	.	.	NNP
cord-334133-61om170g	265	6	,	,	,
cord-334133-61om170g	265	7	2002	2002	CD
cord-334133-61om170g	265	8	)	)	-RRB-
cord-334133-61om170g	265	9	,	,	,
cord-334133-61om170g	265	10	and	and	CC
cord-334133-61om170g	265	11	is	be	VBZ
cord-334133-61om170g	265	12	not	not	RB
cord-334133-61om170g	265	13	known	know	VBN
cord-334133-61om170g	265	14	to	to	TO
cord-334133-61om170g	265	15	be	be	VB
cord-334133-61om170g	265	16	active	active	JJ
cord-334133-61om170g	265	17	in	in	IN
cord-334133-61om170g	265	18	the	the	DT
cord-334133-61om170g	265	19	TGN	TGN	NNP
cord-334133-61om170g	265	20	.	.	.
cord-334133-61om170g	266	1	It	-PRON-	PRP
cord-334133-61om170g	266	2	may	may	MD
cord-334133-61om170g	266	3	be	be	VB
cord-334133-61om170g	266	4	that	that	IN
cord-334133-61om170g	266	5	the	the	DT
cord-334133-61om170g	266	6	amount	amount	NN
cord-334133-61om170g	266	7	of	of	IN
cord-334133-61om170g	266	8	gp41	gp41	NNP
cord-334133-61om170g	266	9	synthesized	synthesize	VBN
cord-334133-61om170g	266	10	saturates	saturate	VBZ
cord-334133-61om170g	266	11	the	the	DT
cord-334133-61om170g	266	12	lysosomal	lysosomal	NN
cord-334133-61om170g	266	13	targeting	target	VBG
cord-334133-61om170g	266	14	system	system	NN
cord-334133-61om170g	266	15	in	in	IN
cord-334133-61om170g	266	16	the	the	DT
cord-334133-61om170g	266	17	TGN	TGN	NNP
cord-334133-61om170g	266	18	,	,	,
cord-334133-61om170g	266	19	allowing	allow	VBG
cord-334133-61om170g	266	20	gp41	gp41	NNP
cord-334133-61om170g	266	21	to	to	TO
cord-334133-61om170g	266	22	reach	reach	VB
cord-334133-61om170g	266	23	the	the	DT
cord-334133-61om170g	266	24	cell	cell	NN
cord-334133-61om170g	266	25	surface	surface	NN
cord-334133-61om170g	266	26	and	and	CC
cord-334133-61om170g	266	27	the	the	DT
cord-334133-61om170g	266	28	first	first	JJ
cord-334133-61om170g	266	29	tyrosine	tyrosine	NN
cord-334133-61om170g	266	30	-	-	HYPH
cord-334133-61om170g	266	31	sorting	sort	VBG
cord-334133-61om170g	266	32	signal	signal	NN
cord-334133-61om170g	266	33	to	to	TO
cord-334133-61om170g	266	34	function	function	VB
cord-334133-61om170g	266	35	as	as	IN
cord-334133-61om170g	266	36	an	an	DT
cord-334133-61om170g	266	37	endocytosis	endocytosis	NN
cord-334133-61om170g	266	38	signal	signal	NN
cord-334133-61om170g	266	39	.	.	.
cord-334133-61om170g	267	1	The	the	DT
cord-334133-61om170g	267	2	possibility	possibility	NN
cord-334133-61om170g	267	3	that	that	IN
cord-334133-61om170g	267	4	the	the	DT
cord-334133-61om170g	267	5	signal	signal	NN
cord-334133-61om170g	267	6	targets	target	NNS
cord-334133-61om170g	267	7	gp41	gp41	NNP
cord-334133-61om170g	267	8	to	to	IN
cord-334133-61om170g	267	9	the	the	DT
cord-334133-61om170g	267	10	lysosomes	lysosome	NNS
cord-334133-61om170g	267	11	is	be	VBZ
cord-334133-61om170g	267	12	consistent	consistent	JJ
cord-334133-61om170g	267	13	with	with	IN
cord-334133-61om170g	267	14	the	the	DT
cord-334133-61om170g	267	15	observation	observation	NN
cord-334133-61om170g	267	16	that	that	IN
cord-334133-61om170g	267	17	the	the	DT
cord-334133-61om170g	267	18	majority	majority	NN
cord-334133-61om170g	267	19	of	of	IN
cord-334133-61om170g	267	20	gp160	gp160	NNP
cord-334133-61om170g	267	21	that	that	WDT
cord-334133-61om170g	267	22	reaches	reach	VBZ
cord-334133-61om170g	267	23	the	the	DT
cord-334133-61om170g	267	24	Golgi	Golgi	NNP
cord-334133-61om170g	267	25	is	be	VBZ
cord-334133-61om170g	267	26	degraded	degrade	VBN
cord-334133-61om170g	267	27	in	in	IN
cord-334133-61om170g	267	28	the	the	DT
cord-334133-61om170g	267	29	lysosomes	lysosome	NNS
cord-334133-61om170g	267	30	(	(	-LRB-
cord-334133-61om170g	267	31	Willey	Willey	NNP
cord-334133-61om170g	267	32	et	et	NNP
cord-334133-61om170g	267	33	al	al	NNP
cord-334133-61om170g	267	34	.	.	NNP
cord-334133-61om170g	267	35	,	,	,
cord-334133-61om170g	267	36	1988	1988	CD
cord-334133-61om170g	267	37	)	)	-RRB-
cord-334133-61om170g	267	38	.	.	.
cord-334133-61om170g	268	1	AP-2	AP-2	NNP
cord-334133-61om170g	268	2	complexes	complex	NNS
cord-334133-61om170g	268	3	have	have	VBP
cord-334133-61om170g	268	4	the	the	DT
cord-334133-61om170g	268	5	broadest	broad	JJS
cord-334133-61om170g	268	6	specificity	specificity	NN
cord-334133-61om170g	268	7	range	range	NN
cord-334133-61om170g	268	8	and	and	CC
cord-334133-61om170g	268	9	associate	associate	VB
cord-334133-61om170g	268	10	with	with	IN
cord-334133-61om170g	268	11	the	the	DT
cord-334133-61om170g	268	12	same	same	JJ
cord-334133-61om170g	268	13	signals	signal	NNS
cord-334133-61om170g	268	14	as	as	IN
cord-334133-61om170g	268	15	AP-1	AP-1	NNP
cord-334133-61om170g	268	16	and	and	CC
cord-334133-61om170g	268	17	AP-3	AP-3	NNP
cord-334133-61om170g	268	18	complexes	complex	NNS
cord-334133-61om170g	269	1	(	(	-LRB-
cord-334133-61om170g	269	2	Ohno	Ohno	NNP
cord-334133-61om170g	269	3	et	et	NNP
cord-334133-61om170g	269	4	al	al	NNP
cord-334133-61om170g	269	5	.	.	NNP
cord-334133-61om170g	269	6	,	,	,
cord-334133-61om170g	269	7	1998	1998	CD
cord-334133-61om170g	269	8	)	)	-RRB-
cord-334133-61om170g	269	9	.	.	.
cord-334133-61om170g	270	1	The	the	DT
cord-334133-61om170g	270	2	endocytosis	endocytosis	NN
cord-334133-61om170g	270	3	function	function	NN
cord-334133-61om170g	270	4	of	of	IN
cord-334133-61om170g	270	5	the	the	DT
cord-334133-61om170g	270	6	first	first	JJ
cord-334133-61om170g	270	7	tyrosine	tyrosine	NN
cord-334133-61om170g	270	8	-	-	HYPH
cord-334133-61om170g	270	9	sorting	sort	VBG
cord-334133-61om170g	270	10	signal	signal	NN
cord-334133-61om170g	270	11	may	may	MD
cord-334133-61om170g	270	12	enable	enable	VB
cord-334133-61om170g	270	13	plasma	plasma	NN
cord-334133-61om170g	270	14	membrane	membrane	NN
cord-334133-61om170g	270	15	gp41	gp41	NNP
cord-334133-61om170g	270	16	to	to	TO
cord-334133-61om170g	270	17	be	be	VB
cord-334133-61om170g	270	18	re	re	VBN
cord-334133-61om170g	270	19	-	-	VBN
cord-334133-61om170g	270	20	directed	direct	VBN
cord-334133-61om170g	270	21	to	to	IN
cord-334133-61om170g	270	22	the	the	DT
cord-334133-61om170g	270	23	lysosomes	lysosome	NNS
cord-334133-61om170g	270	24	if	if	IN
cord-334133-61om170g	270	25	it	-PRON-	PRP
cord-334133-61om170g	270	26	escapes	escape	VBZ
cord-334133-61om170g	270	27	that	that	DT
cord-334133-61om170g	270	28	route	route	NN
cord-334133-61om170g	270	29	initially	initially	RB
cord-334133-61om170g	270	30	(	(	-LRB-
cord-334133-61om170g	270	31	Ohno	Ohno	NNP
cord-334133-61om170g	270	32	et	et	NNP
cord-334133-61om170g	270	33	al	al	NNP
cord-334133-61om170g	270	34	.	.	NNP
cord-334133-61om170g	270	35	,	,	,
cord-334133-61om170g	270	36	1998	1998	CD
cord-334133-61om170g	270	37	)	)	-RRB-
cord-334133-61om170g	270	38	.	.	.
cord-334133-61om170g	271	1	The	the	DT
cord-334133-61om170g	271	2	second	second	JJ
cord-334133-61om170g	271	3	tyrosine	tyrosine	NN
cord-334133-61om170g	271	4	-	-	HYPH
cord-334133-61om170g	271	5	dependent	dependent	JJ
cord-334133-61om170g	271	6	sorting	sorting	NN
cord-334133-61om170g	271	7	signal	signal	NN
cord-334133-61om170g	271	8	(	(	-LRB-
cord-334133-61om170g	271	9	775	775	CD
cord-334133-61om170g	271	10	YHRL	YHRL	NNP
cord-334133-61om170g	271	11	778	778	CD
cord-334133-61om170g	271	12	)	)	-RRB-
cord-334133-61om170g	271	13	has	have	VBZ
cord-334133-61om170g	271	14	no	no	DT
cord-334133-61om170g	271	15	preceding	precede	VBG
cord-334133-61om170g	271	16	glycine	glycine	NN
cord-334133-61om170g	271	17	,	,	,
cord-334133-61om170g	271	18	and	and	CC
cord-334133-61om170g	271	19	is	be	VBZ
cord-334133-61om170g	271	20	non	non	JJ
cord-334133-61om170g	271	21	-	-	JJ
cord-334133-61om170g	271	22	functional	functional	JJ
cord-334133-61om170g	271	23	in	in	IN
cord-334133-61om170g	271	24	the	the	DT
cord-334133-61om170g	271	25	context	context	NN
cord-334133-61om170g	271	26	of	of	IN
cord-334133-61om170g	271	27	the	the	DT
cord-334133-61om170g	271	28	1-MSD	1-msd	CD
cord-334133-61om170g	271	29	model	model	NN
cord-334133-61om170g	271	30	of	of	IN
cord-334133-61om170g	271	31	gp41	gp41	NNP
cord-334133-61om170g	271	32	(	(	-LRB-
cord-334133-61om170g	271	33	Boge	Boge	NNP
cord-334133-61om170g	271	34	et	et	NNP
cord-334133-61om170g	271	35	al	al	NNP
cord-334133-61om170g	271	36	.	.	NNP
cord-334133-61om170g	271	37	,	,	,
cord-334133-61om170g	271	38	1998	1998	CD
cord-334133-61om170g	271	39	;	;	:
cord-334133-61om170g	272	1	Rowell	Rowell	NNP
cord-334133-61om170g	272	2	et	et	NNP
cord-334133-61om170g	272	3	al	al	NNP
cord-334133-61om170g	272	4	.	.	NNP
cord-334133-61om170g	272	5	,	,	,
cord-334133-61om170g	272	6	1995	1995	CD
cord-334133-61om170g	272	7	)	)	-RRB-
cord-334133-61om170g	272	8	.	.	.
cord-334133-61om170g	273	1	It	-PRON-	PRP
cord-334133-61om170g	273	2	is	be	VBZ
cord-334133-61om170g	273	3	situated	situate	VBN
cord-334133-61om170g	273	4	63	63	CD
cord-334133-61om170g	273	5	and	and	CC
cord-334133-61om170g	273	6	12	12	CD
cord-334133-61om170g	273	7	residues	residue	NNS
cord-334133-61om170g	273	8	from	from	IN
cord-334133-61om170g	273	9	the	the	DT
cord-334133-61om170g	273	10	membrane	membrane	NN
cord-334133-61om170g	273	11	in	in	IN
cord-334133-61om170g	273	12	the	the	DT
cord-334133-61om170g	273	13	1-MSD	1-msd	CD
cord-334133-61om170g	273	14	and	and	CC
cord-334133-61om170g	273	15	3-MSD	3-msd	CD
cord-334133-61om170g	273	16	models	model	NNS
cord-334133-61om170g	273	17	,	,	,
cord-334133-61om170g	273	18	respectively	respectively	RB
cord-334133-61om170g	273	19	,	,	,
cord-334133-61om170g	273	20	the	the	DT
cord-334133-61om170g	273	21	latter	latter	JJ
cord-334133-61om170g	273	22	being	be	VBG
cord-334133-61om170g	273	23	close	close	JJ
cord-334133-61om170g	273	24	to	to	IN
cord-334133-61om170g	273	25	the	the	DT
cord-334133-61om170g	273	26	optimal	optimal	JJ
cord-334133-61om170g	273	27	7	7	CD
cord-334133-61om170g	273	28	-	-	SYM
cord-334133-61om170g	273	29	11	11	CD
cord-334133-61om170g	273	30	residue	residue	NN
cord-334133-61om170g	273	31	distance	distance	NN
cord-334133-61om170g	273	32	.	.	.
cord-334133-61om170g	274	1	The	the	DT
cord-334133-61om170g	274	2	residues	residue	NNS
cord-334133-61om170g	274	3	of	of	IN
cord-334133-61om170g	274	4	the	the	DT
cord-334133-61om170g	274	5	second	second	JJ
cord-334133-61om170g	274	6	signal	signal	NN
cord-334133-61om170g	274	7	are	be	VBP
cord-334133-61om170g	274	8	variably	variably	RB
cord-334133-61om170g	274	9	conserved	conserve	VBN
cord-334133-61om170g	274	10	:	:	:
cord-334133-61om170g	274	11	772	772	CD
cord-334133-61om170g	274	12	L	l	NN
cord-334133-61om170g	274	13	=	=	SYM
cord-334133-61om170g	274	14	94.5	94.5	CD
cord-334133-61om170g	274	15	%	%	NN
cord-334133-61om170g	274	16	,	,	,
cord-334133-61om170g	274	17	773	773	CD
cord-334133-61om170g	274	18	F	f	NN
cord-334133-61om170g	274	19	=	=	SYM
cord-334133-61om170g	274	20	96.8	96.8	CD
cord-334133-61om170g	274	21	%	%	NN
cord-334133-61om170g	274	22	,	,	,
cord-334133-61om170g	274	23	774	774	CD
cord-334133-61om170g	274	24	S	s	NN
cord-334133-61om170g	274	25	=	=	SYM
cord-334133-61om170g	274	26	86.0	86.0	CD
cord-334133-61om170g	274	27	%	%	NN
cord-334133-61om170g	274	28	,	,	,
cord-334133-61om170g	274	29	775	775	CD
cord-334133-61om170g	274	30	Y	y	NN
cord-334133-61om170g	274	31	=	=	SYM
cord-334133-61om170g	274	32	99.7	99.7	CD
cord-334133-61om170g	274	33	%	%	NN
cord-334133-61om170g	274	34	,	,	,
cord-334133-61om170g	274	35	776	776	CD
cord-334133-61om170g	274	36	H	h	NN
cord-334133-61om170g	274	37	=	=	SYM
cord-334133-61om170g	274	38	89.3	89.3	CD
cord-334133-61om170g	274	39	%	%	NN
cord-334133-61om170g	274	40	,	,	,
cord-334133-61om170g	274	41	777	777	CD
cord-334133-61om170g	274	42	R	r	NN
cord-334133-61om170g	274	43	=	=	SYM
cord-334133-61om170g	274	44	86.5	86.5	CD
cord-334133-61om170g	274	45	%	%	NN
cord-334133-61om170g	274	46	,	,	,
cord-334133-61om170g	274	47	and	and	CC
cord-334133-61om170g	274	48	778	778	CD
cord-334133-61om170g	274	49	L	l	NN
cord-334133-61om170g	274	50	=	=	SYM
cord-334133-61om170g	274	51	99.8	99.8	CD
cord-334133-61om170g	274	52	%	%	NN
cord-334133-61om170g	274	53	.	.	.
cord-334133-61om170g	275	1	The	the	DT
cord-334133-61om170g	275	2	F	F	NNP
cord-334133-61om170g	275	3	at	at	IN
cord-334133-61om170g	275	4	position	position	NN
cord-334133-61om170g	275	5	Y	Y	NNP
cord-334133-61om170g	275	6	À	à	NN
cord-334133-61om170g	275	7	2	2	CD
cord-334133-61om170g	275	8	,	,	,
cord-334133-61om170g	275	9	R	r	NN
cord-334133-61om170g	275	10	at	at	IN
cord-334133-61om170g	275	11	Y	y	NN
cord-334133-61om170g	276	1	+	+	SYM
cord-334133-61om170g	276	2	2	2	CD
cord-334133-61om170g	276	3	,	,	,
cord-334133-61om170g	276	4	and	and	CC
cord-334133-61om170g	276	5	L	l	NN
cord-334133-61om170g	276	6	at	at	IN
cord-334133-61om170g	276	7	Y	Y	NNP
cord-334133-61om170g	276	8	+	+	CC
cord-334133-61om170g	276	9	3	3	CD
cord-334133-61om170g	276	10	suggest	suggest	VBP
cord-334133-61om170g	276	11	that	that	IN
cord-334133-61om170g	276	12	the	the	DT
cord-334133-61om170g	276	13	signal	signal	NN
cord-334133-61om170g	276	14	interacts	interact	VBZ
cord-334133-61om170g	276	15	with	with	IN
cord-334133-61om170g	276	16	the	the	DT
cord-334133-61om170g	276	17	AP-2	AP-2	NNP
cord-334133-61om170g	276	18	complex	complex	NN
cord-334133-61om170g	276	19	(	(	-LRB-
cord-334133-61om170g	276	20	Table	table	NN
cord-334133-61om170g	276	21	2	2	CD
cord-334133-61om170g	276	22	)	)	-RRB-
cord-334133-61om170g	276	23	.	.	.
cord-334133-61om170g	277	1	The	the	DT
cord-334133-61om170g	277	2	lack	lack	NN
cord-334133-61om170g	277	3	of	of	IN
cord-334133-61om170g	277	4	an	an	DT
cord-334133-61om170g	277	5	R	r	NN
cord-334133-61om170g	277	6	at	at	IN
cord-334133-61om170g	277	7	Y	Y	NNP
cord-334133-61om170g	277	8	À	à	NN
cord-334133-61om170g	277	9	3	3	CD
cord-334133-61om170g	277	10	,	,	,
cord-334133-61om170g	277	11	glycine	glycine	NN
cord-334133-61om170g	277	12	at	at	IN
cord-334133-61om170g	277	13	Y	Y	NNP
cord-334133-61om170g	277	14	À	à	NN
cord-334133-61om170g	277	15	1	1	CD
cord-334133-61om170g	277	16	,	,	,
cord-334133-61om170g	277	17	and	and	CC
cord-334133-61om170g	277	18	proline	proline	NN
cord-334133-61om170g	277	19	at	at	IN
cord-334133-61om170g	277	20	Y	Y	NNP
cord-334133-61om170g	277	21	+	+	SYM
cord-334133-61om170g	277	22	2	2	CD
cord-334133-61om170g	277	23	,	,	,
cord-334133-61om170g	277	24	and	and	CC
cord-334133-61om170g	277	25	the	the	DT
cord-334133-61om170g	277	26	fact	fact	NN
cord-334133-61om170g	277	27	that	that	IN
cord-334133-61om170g	277	28	it	-PRON-	PRP
cord-334133-61om170g	277	29	is	be	VBZ
cord-334133-61om170g	277	30	not	not	RB
cord-334133-61om170g	277	31	within	within	IN
cord-334133-61om170g	277	32	the	the	DT
cord-334133-61om170g	277	33	favored	favor	VBN
cord-334133-61om170g	277	34	distance	distance	NN
cord-334133-61om170g	277	35	from	from	IN
cord-334133-61om170g	277	36	the	the	DT
cord-334133-61om170g	277	37	membrane	membrane	NN
cord-334133-61om170g	277	38	(	(	-LRB-
cord-334133-61om170g	277	39	Rohrer	Rohrer	NNP
cord-334133-61om170g	277	40	et	et	NNP
cord-334133-61om170g	277	41	al	al	NNP
cord-334133-61om170g	277	42	.	.	NNP
cord-334133-61om170g	277	43	,	,	,
cord-334133-61om170g	277	44	1996	1996	CD
cord-334133-61om170g	277	45	)	)	-RRB-
cord-334133-61om170g	277	46	,	,	,
cord-334133-61om170g	277	47	indicate	indicate	VBP
cord-334133-61om170g	277	48	that	that	IN
cord-334133-61om170g	277	49	this	this	DT
cord-334133-61om170g	277	50	signal	signal	NN
cord-334133-61om170g	277	51	is	be	VBZ
cord-334133-61om170g	277	52	not	not	RB
cord-334133-61om170g	277	53	optimal	optimal	JJ
cord-334133-61om170g	277	54	for	for	IN
cord-334133-61om170g	277	55	interacting	interact	VBG
cord-334133-61om170g	277	56	with	with	IN
cord-334133-61om170g	277	57	AP-1	AP-1	NNP
cord-334133-61om170g	277	58	or	or	CC
cord-334133-61om170g	277	59	AP-3	AP-3	NNP
cord-334133-61om170g	277	60	complexes	complex	NNS
cord-334133-61om170g	277	61	.	.	.
cord-334133-61om170g	278	1	AP-3	AP-3	NNP
cord-334133-61om170g	278	2	complexes	complex	NNS
cord-334133-61om170g	278	3	disfavor	disfavor	VBP
cord-334133-61om170g	278	4	serine	serine	NN
cord-334133-61om170g	278	5	at	at	IN
cord-334133-61om170g	278	6	position	position	NN
cord-334133-61om170g	278	7	Y	Y	NNP
cord-334133-61om170g	278	8	À	à	NN
cord-334133-61om170g	278	9	1	1	CD
cord-334133-61om170g	278	10	and	and	CC
cord-334133-61om170g	278	11	makes	make	VBZ
cord-334133-61om170g	278	12	this	this	DT
cord-334133-61om170g	278	13	interaction	interaction	NN
cord-334133-61om170g	278	14	less	less	RBR
cord-334133-61om170g	278	15	likely	likely	JJ
cord-334133-61om170g	278	16	(	(	-LRB-
cord-334133-61om170g	278	17	Ohno	Ohno	NNP
cord-334133-61om170g	278	18	et	et	NNP
cord-334133-61om170g	278	19	al	al	NNP
cord-334133-61om170g	278	20	.	.	NNP
cord-334133-61om170g	278	21	,	,	,
cord-334133-61om170g	278	22	,	,	,
cord-334133-61om170g	278	23	1998	1998	CD
cord-334133-61om170g	278	24	.	.	.
cord-334133-61om170g	279	1	As	as	IN
cord-334133-61om170g	279	2	yet	yet	RB
cord-334133-61om170g	279	3	there	there	EX
cord-334133-61om170g	279	4	is	be	VBZ
cord-334133-61om170g	279	5	no	no	DT
cord-334133-61om170g	279	6	evidence	evidence	NN
cord-334133-61om170g	279	7	that	that	IN
cord-334133-61om170g	279	8	this	this	DT
cord-334133-61om170g	279	9	signal	signal	NN
cord-334133-61om170g	279	10	is	be	VBZ
cord-334133-61om170g	279	11	functional	functional	JJ
cord-334133-61om170g	279	12	in	in	IN
cord-334133-61om170g	279	13	gp41	gp41	NNP
cord-334133-61om170g	279	14	(	(	-LRB-
cord-334133-61om170g	279	15	Boge	Boge	NNP
cord-334133-61om170g	279	16	et	et	NNP
cord-334133-61om170g	279	17	al	al	NNP
cord-334133-61om170g	279	18	.	.	NNP
cord-334133-61om170g	279	19	,	,	,
cord-334133-61om170g	279	20	1998	1998	CD
cord-334133-61om170g	279	21	;	;	:
cord-334133-61om170g	280	1	Rowell	Rowell	NNP
cord-334133-61om170g	280	2	et	et	NNP
cord-334133-61om170g	280	3	al	al	NNP
cord-334133-61om170g	280	4	.	.	NNP
cord-334133-61om170g	280	5	,	,	,
cord-334133-61om170g	280	6	1995	1995	CD
cord-334133-61om170g	280	7	)	)	-RRB-
cord-334133-61om170g	280	8	.	.	.
cord-334133-61om170g	281	1	A	a	DT
cord-334133-61om170g	281	2	peptide	peptide	NN
cord-334133-61om170g	281	3	containing	contain	VBG
cord-334133-61om170g	281	4	the	the	DT
cord-334133-61om170g	281	5	signal	signal	NN
cord-334133-61om170g	281	6	interacted	interact	VBN
cord-334133-61om170g	281	7	Table	Table	NNP
cord-334133-61om170g	281	8	2	2	CD
cord-334133-61om170g	281	9	Comparison	comparison	NN
cord-334133-61om170g	281	10	of	of	IN
cord-334133-61om170g	281	11	the	the	DT
cord-334133-61om170g	281	12	preferences	preference	NNS
cord-334133-61om170g	281	13	of	of	IN
cord-334133-61om170g	281	14	AP	AP	NNP
cord-334133-61om170g	281	15	complexes	complex	NNS
cord-334133-61om170g	281	16	for	for	IN
cord-334133-61om170g	281	17	cellular	cellular	JJ
cord-334133-61om170g	281	18	tyrosine	tyrosine	NN
cord-334133-61om170g	281	19	-	-	HYPH
cord-334133-61om170g	281	20	dependent	dependent	JJ
cord-334133-61om170g	281	21	sorting	sorting	NN
cord-334133-61om170g	281	22	signals	signal	NNS
cord-334133-61om170g	281	23	a	a	DT
cord-334133-61om170g	281	24	with	with	IN
cord-334133-61om170g	281	25	the	the	DT
cord-334133-61om170g	281	26	consensus	consensus	NN
cord-334133-61om170g	281	27	sequence	sequence	NN
cord-334133-61om170g	281	28	for	for	IN
cord-334133-61om170g	281	29	the	the	DT
cord-334133-61om170g	281	30	first	first	JJ
cord-334133-61om170g	281	31	and	and	CC
cord-334133-61om170g	281	32	second	second	JJ
cord-334133-61om170g	281	33	potential	potential	JJ
cord-334133-61om170g	281	34	tyrosine	tyrosine	NN
cord-334133-61om170g	281	35	-	-	HYPH
cord-334133-61om170g	281	36	dependent	dependent	JJ
cord-334133-61om170g	281	37	sorting	sorting	NN
cord-334133-61om170g	281	38	signals	signal	NNS
cord-334133-61om170g	281	39	of	of	IN
cord-334133-61om170g	281	40	the	the	DT
cord-334133-61om170g	281	41	gp41	gp41	NN
cord-334133-61om170g	281	42	of	of	IN
cord-334133-61om170g	281	43	HIV-1	HIV-1	NNP
cord-334133-61om170g	281	44	clades	clade	NNS
cord-334133-61om170g	281	45	A	a	DT
cord-334133-61om170g	281	46	to	to	IN
cord-334133-61om170g	281	47	D	D	NNP
cord-334133-61om170g	281	48	Position	position	NN
cord-334133-61om170g	281	49	(	(	-LRB-
cord-334133-61om170g	281	50	relative	relative	JJ
cord-334133-61om170g	281	51	to	to	IN
cord-334133-61om170g	281	52	Y	Y	NNP
cord-334133-61om170g	281	53	)	)	-RRB-
cord-334133-61om170g	282	1	AP-1	AP-1	NNP
cord-334133-61om170g	283	1	preferences	preference	NNS
cord-334133-61om170g	284	1	AP-2	AP-2	NNP
cord-334133-61om170g	284	2	preferences	preference	NNS
cord-334133-61om170g	285	1	AP-3	AP-3	NNP
cord-334133-61om170g	285	2	preferences	preference	NNS
cord-334133-61om170g	285	3	HIV-1	HIV-1	NNP
cord-334133-61om170g	285	4	tyrosine	tyrosine	NN
cord-334133-61om170g	285	5	-	-	HYPH
cord-334133-61om170g	285	6	dependent	dependent	JJ
cord-334133-61om170g	285	7	sorting	sorting	NN
cord-334133-61om170g	285	8	signal	signal	NN
cord-334133-61om170g	285	9	sequences	sequence	NNS
cord-334133-61om170g	286	1	First	First	NNP
cord-334133-61om170g	286	2	Second	Second	NNP
cord-334133-61om170g	286	3	Np	Np	NNP
cord-334133-61om170g	286	4	,	,	,
cord-334133-61om170g	286	5	no	no	DT
cord-334133-61om170g	286	6	preference	preference	NN
cord-334133-61om170g	286	7	known	know	VBN
cord-334133-61om170g	286	8	at	at	IN
cord-334133-61om170g	286	9	this	this	DT
cord-334133-61om170g	286	10	position	position	NN
cord-334133-61om170g	286	11	;	;	.
cord-334133-61om170g	287	1	x	x	LS
cord-334133-61om170g	287	2	,	,	,
cord-334133-61om170g	287	3	any	any	DT
cord-334133-61om170g	287	4	amino	amino	NN
cord-334133-61om170g	287	5	acid	acid	NN
cord-334133-61om170g	287	6	residue	residue	NN
cord-334133-61om170g	287	7	;	;	:
cord-334133-61om170g	287	8	B	b	NN
cord-334133-61om170g	287	9	,	,	,
cord-334133-61om170g	287	10	a	a	DT
cord-334133-61om170g	287	11	bulky	bulky	JJ
cord-334133-61om170g	287	12	hydrophobic	hydrophobic	JJ
cord-334133-61om170g	287	13	residue	residue	NN
cord-334133-61om170g	287	14	.	.	.
cord-334133-61om170g	288	1	a	a	DT
cord-334133-61om170g	288	2	Boll	Boll	NNP
cord-334133-61om170g	288	3	et	et	FW
cord-334133-61om170g	288	4	al	al	NNP
cord-334133-61om170g	288	5	.	.	.
cord-334133-61om170g	289	1	(	(	-LRB-
cord-334133-61om170g	289	2	1996	1996	CD
cord-334133-61om170g	289	3	)	)	-RRB-
cord-334133-61om170g	289	4	,	,	,
cord-334133-61om170g	289	5	Heilker	Heilker	NNP
cord-334133-61om170g	289	6	et	et	NNP
cord-334133-61om170g	289	7	al	al	NNP
cord-334133-61om170g	289	8	.	.	.
cord-334133-61om170g	290	1	(	(	-LRB-
cord-334133-61om170g	290	2	1999	1999	CD
cord-334133-61om170g	290	3	)	)	-RRB-
cord-334133-61om170g	290	4	,	,	,
cord-334133-61om170g	290	5	Hö	Hö	NNP
cord-334133-61om170g	290	6	ning	ning	NNP
cord-334133-61om170g	290	7	et	et	FW
cord-334133-61om170g	290	8	al	al	NNP
cord-334133-61om170g	290	9	.	.	.
cord-334133-61om170g	291	1	(	(	-LRB-
cord-334133-61om170g	291	2	1996	1996	CD
cord-334133-61om170g	291	3	,	,	,
cord-334133-61om170g	291	4	Ohno	Ohno	NNP
cord-334133-61om170g	291	5	et	et	NNP
cord-334133-61om170g	291	6	al	al	NNP
cord-334133-61om170g	291	7	.	.	.
cord-334133-61om170g	292	1	(	(	-LRB-
cord-334133-61om170g	292	2	1995	1995	CD
cord-334133-61om170g	292	3	Ohno	Ohno	NNP
cord-334133-61om170g	292	4	et	et	NNP
cord-334133-61om170g	292	5	al	al	NNP
cord-334133-61om170g	292	6	.	.	.
cord-334133-61om170g	293	1	(	(	-LRB-
cord-334133-61om170g	293	2	,	,	,
cord-334133-61om170g	293	3	1996	1996	CD
cord-334133-61om170g	293	4	Ohno	Ohno	NNP
cord-334133-61om170g	293	5	et	et	NNP
cord-334133-61om170g	293	6	al	al	NNP
cord-334133-61om170g	293	7	.	.	.
cord-334133-61om170g	294	1	(	(	-LRB-
cord-334133-61om170g	294	2	,	,	,
cord-334133-61om170g	294	3	1998	1998	CD
cord-334133-61om170g	294	4	,	,	,
cord-334133-61om170g	294	5	Ooi	Ooi	NNP
cord-334133-61om170g	294	6	et	et	NNP
cord-334133-61om170g	294	7	al	al	NNP
cord-334133-61om170g	294	8	.	.	.
cord-334133-61om170g	295	1	(	(	-LRB-
cord-334133-61om170g	295	2	1997	1997	CD
cord-334133-61om170g	295	3	)	)	-RRB-
cord-334133-61om170g	295	4	,	,	,
cord-334133-61om170g	295	5	Owen	Owen	NNP
cord-334133-61om170g	295	6	and	and	CC
cord-334133-61om170g	295	7	Evans	Evans	NNP
cord-334133-61om170g	295	8	(	(	-LRB-
cord-334133-61om170g	295	9	1998	1998	CD
cord-334133-61om170g	295	10	)	)	-RRB-
cord-334133-61om170g	295	11	,	,	,
cord-334133-61om170g	295	12	Simpson	Simpson	NNP
cord-334133-61om170g	295	13	et	et	NNP
cord-334133-61om170g	295	14	al	al	NNP
cord-334133-61om170g	295	15	.	.	.
cord-334133-61om170g	296	1	(	(	-LRB-
cord-334133-61om170g	296	2	1997	1997	CD
cord-334133-61om170g	296	3	)	)	-RRB-
cord-334133-61om170g	296	4	,	,	,
cord-334133-61om170g	296	5	Stephens	Stephens	NNP
cord-334133-61om170g	296	6	and	and	CC
cord-334133-61om170g	296	7	Banting	Banting	NNP
cord-334133-61om170g	296	8	(	(	-LRB-
cord-334133-61om170g	296	9	1998	1998	CD
cord-334133-61om170g	296	10	)	)	-RRB-
cord-334133-61om170g	296	11	,	,	,
cord-334133-61om170g	296	12	Stepp	Stepp	NNP
cord-334133-61om170g	296	13	et	et	NNP
cord-334133-61om170g	296	14	al	al	NNP
cord-334133-61om170g	296	15	.	.	.
cord-334133-61om170g	297	1	(	(	-LRB-
cord-334133-61om170g	297	2	1997	1997	CD
cord-334133-61om170g	297	3	)	)	-RRB-
cord-334133-61om170g	297	4	.	.	.
cord-334133-61om170g	298	1	strongly	strongly	RB
cord-334133-61om170g	298	2	with	with	IN
cord-334133-61om170g	298	3	the	the	DT
cord-334133-61om170g	298	4	medium	medium	JJ
cord-334133-61om170g	298	5	subunit	subunit	NN
cord-334133-61om170g	298	6	of	of	IN
cord-334133-61om170g	298	7	AP-2	AP-2	NNP
cord-334133-61om170g	298	8	(	(	-LRB-
cord-334133-61om170g	298	9	Boge	Boge	NNP
cord-334133-61om170g	298	10	et	et	NNP
cord-334133-61om170g	298	11	al	al	NNP
cord-334133-61om170g	298	12	.	.	.
cord-334133-61om170g	299	1	,	,	,
cord-334133-61om170g	299	2	1998	1998	CD
cord-334133-61om170g	299	3	;	;	:
cord-334133-61om170g	299	4	Ohno	Ohno	NNP
cord-334133-61om170g	299	5	et	et	NNP
cord-334133-61om170g	299	6	al	al	NNP
cord-334133-61om170g	299	7	.	.	NNP
cord-334133-61om170g	299	8	,	,	,
cord-334133-61om170g	299	9	1997	1997	CD
cord-334133-61om170g	299	10	)	)	-RRB-
cord-334133-61om170g	299	11	,	,	,
cord-334133-61om170g	299	12	but	but	CC
cord-334133-61om170g	299	13	the	the	DT
cord-334133-61om170g	299	14	presence	presence	NN
cord-334133-61om170g	299	15	of	of	IN
cord-334133-61om170g	299	16	a	a	DT
cord-334133-61om170g	299	17	major	major	JJ
cord-334133-61om170g	299	18	upstream	upstream	JJ
cord-334133-61om170g	299	19	sequence	sequence	NN
cord-334133-61om170g	299	20	in	in	IN
cord-334133-61om170g	299	21	the	the	DT
cord-334133-61om170g	299	22	1-MSD	1-msd	CD
cord-334133-61om170g	299	23	model	model	NN
cord-334133-61om170g	299	24	could	could	MD
cord-334133-61om170g	299	25	alter	alter	VB
cord-334133-61om170g	299	26	its	-PRON-	PRP$
cord-334133-61om170g	299	27	environment	environment	NN
cord-334133-61om170g	299	28	and	and	CC
cord-334133-61om170g	299	29	its	-PRON-	PRP$
cord-334133-61om170g	299	30	possible	possible	JJ
cord-334133-61om170g	299	31	interaction	interaction	NN
cord-334133-61om170g	299	32	with	with	IN
cord-334133-61om170g	299	33	the	the	DT
cord-334133-61om170g	299	34	AP-2	AP-2	NNP
cord-334133-61om170g	299	35	complex	complex	NN
cord-334133-61om170g	299	36	.	.	.
cord-334133-61om170g	300	1	All	all	DT
cord-334133-61om170g	300	2	HIV-1	HIV-1	NNP
cord-334133-61om170g	300	3	gp41	gp41	NNP
cord-334133-61om170g	300	4	tail	tail	NN
cord-334133-61om170g	300	5	sequences	sequence	NNS
cord-334133-61om170g	300	6	have	have	VBP
cord-334133-61om170g	300	7	a	a	DT
cord-334133-61om170g	300	8	potential	potential	JJ
cord-334133-61om170g	300	9	N	n	CD
cord-334133-61om170g	300	10	-	-	HYPH
cord-334133-61om170g	300	11	terminal	terminal	NN
cord-334133-61om170g	300	12	GYxxf	GYxxf	NNP
cord-334133-61om170g	300	13	-	-	HYPH
cord-334133-61om170g	300	14	sorting	sort	VBG
cord-334133-61om170g	300	15	signal	signal	NN
cord-334133-61om170g	300	16	of	of	IN
cord-334133-61om170g	300	17	the	the	DT
cord-334133-61om170g	300	18	type	type	NN
cord-334133-61om170g	300	19	that	that	WDT
cord-334133-61om170g	300	20	would	would	MD
cord-334133-61om170g	300	21	be	be	VB
cord-334133-61om170g	300	22	expected	expect	VBN
cord-334133-61om170g	300	23	to	to	TO
cord-334133-61om170g	300	24	interact	interact	VB
cord-334133-61om170g	300	25	strongly	strongly	RB
cord-334133-61om170g	300	26	with	with	IN
cord-334133-61om170g	300	27	AP-1	AP-1	NNP
cord-334133-61om170g	300	28	and	and	CC
cord-334133-61om170g	300	29	AP-3	AP-3	NNP
cord-334133-61om170g	300	30	complexes	complex	NNS
cord-334133-61om170g	300	31	.	.	.
cord-334133-61om170g	301	1	Thus	thus	RB
cord-334133-61om170g	301	2	,	,	,
cord-334133-61om170g	301	3	with	with	IN
cord-334133-61om170g	301	4	the	the	DT
cord-334133-61om170g	301	5	critical	critical	JJ
cord-334133-61om170g	301	6	7-residue	7-residue	CD
cord-334133-61om170g	301	7	spacing	spacing	NN
cord-334133-61om170g	301	8	from	from	IN
cord-334133-61om170g	301	9	the	the	DT
cord-334133-61om170g	301	10	membrane	membrane	NN
cord-334133-61om170g	301	11	,	,	,
cord-334133-61om170g	301	12	the	the	DT
cord-334133-61om170g	301	13	signal	signal	NN
cord-334133-61om170g	301	14	is	be	VBZ
cord-334133-61om170g	301	15	likely	likely	JJ
cord-334133-61om170g	301	16	to	to	TO
cord-334133-61om170g	301	17	be	be	VB
cord-334133-61om170g	301	18	functionally	functionally	RB
cord-334133-61om170g	301	19	important	important	JJ
cord-334133-61om170g	301	20	in	in	IN
cord-334133-61om170g	301	21	targeting	target	VBG
cord-334133-61om170g	301	22	TGN	TGN	NNP
cord-334133-61om170g	301	23	gp41	gp41	NNP
cord-334133-61om170g	301	24	to	to	IN
cord-334133-61om170g	301	25	lysosomes	lysosome	NNS
cord-334133-61om170g	301	26	.	.	.
cord-334133-61om170g	302	1	If	if	IN
cord-334133-61om170g	302	2	the	the	DT
cord-334133-61om170g	302	3	signal	signal	NN
cord-334133-61om170g	302	4	was	be	VBD
cord-334133-61om170g	302	5	required	require	VBN
cord-334133-61om170g	302	6	only	only	RB
cord-334133-61om170g	302	7	for	for	IN
cord-334133-61om170g	302	8	endocytosis	endocytosis	NN
cord-334133-61om170g	302	9	,	,	,
cord-334133-61om170g	302	10	it	-PRON-	PRP
cord-334133-61om170g	302	11	is	be	VBZ
cord-334133-61om170g	302	12	unlikely	unlikely	JJ
cord-334133-61om170g	302	13	that	that	IN
cord-334133-61om170g	302	14	the	the	DT
cord-334133-61om170g	302	15	G	G	NNP
cord-334133-61om170g	302	16	at	at	IN
cord-334133-61om170g	302	17	position	position	NN
cord-334133-61om170g	302	18	Y	Y	NNP
cord-334133-61om170g	302	19	À	à	NN
cord-334133-61om170g	302	20	1	1	CD
cord-334133-61om170g	302	21	,	,	,
cord-334133-61om170g	302	22	R	r	NN
cord-334133-61om170g	302	23	at	at	IN
cord-334133-61om170g	302	24	Y	Y	NNP
cord-334133-61om170g	302	25	À	à	NN
cord-334133-61om170g	302	26	3	3	CD
cord-334133-61om170g	302	27	,	,	,
cord-334133-61om170g	302	28	and	and	CC
cord-334133-61om170g	302	29	the	the	DT
cord-334133-61om170g	302	30	7-residue	7-residue	CD
cord-334133-61om170g	302	31	spacing	spacing	NN
cord-334133-61om170g	302	32	from	from	IN
cord-334133-61om170g	302	33	the	the	DT
cord-334133-61om170g	302	34	membrane	membrane	NN
cord-334133-61om170g	302	35	would	would	MD
cord-334133-61om170g	302	36	be	be	VB
cord-334133-61om170g	302	37	so	so	RB
cord-334133-61om170g	302	38	highly	highly	RB
cord-334133-61om170g	302	39	conserved	conserve	VBN
cord-334133-61om170g	302	40	.	.	.
cord-334133-61om170g	303	1	However	however	RB
cord-334133-61om170g	303	2	,	,	,
cord-334133-61om170g	303	3	this	this	DT
cord-334133-61om170g	303	4	would	would	MD
cord-334133-61om170g	303	5	not	not	RB
cord-334133-61om170g	303	6	preclude	preclude	VB
cord-334133-61om170g	303	7	it	-PRON-	PRP
cord-334133-61om170g	303	8	from	from	IN
cord-334133-61om170g	303	9	functioning	function	VBG
cord-334133-61om170g	303	10	as	as	IN
cord-334133-61om170g	303	11	an	an	DT
cord-334133-61om170g	303	12	endocytosis	endocytosis	NN
cord-334133-61om170g	303	13	signal	signal	NN
cord-334133-61om170g	303	14	at	at	IN
cord-334133-61om170g	303	15	the	the	DT
cord-334133-61om170g	303	16	cell	cell	NN
cord-334133-61om170g	303	17	surface	surface	NN
cord-334133-61om170g	303	18	.	.	.
cord-334133-61om170g	304	1	The	the	DT
cord-334133-61om170g	304	2	second	second	JJ
cord-334133-61om170g	304	3	Yxxf	Yxxf	NNP
cord-334133-61om170g	304	4	sequence	sequence	NN
cord-334133-61om170g	304	5	is	be	VBZ
cord-334133-61om170g	304	6	not	not	RB
cord-334133-61om170g	304	7	so	so	RB
cord-334133-61om170g	304	8	well	well	RB
cord-334133-61om170g	304	9	conserved	conserved	JJ
cord-334133-61om170g	304	10	,	,	,
cord-334133-61om170g	304	11	is	be	VBZ
cord-334133-61om170g	304	12	63	63	CD
cord-334133-61om170g	304	13	residues	residue	NNS
cord-334133-61om170g	304	14	from	from	IN
cord-334133-61om170g	304	15	the	the	DT
cord-334133-61om170g	304	16	membrane	membrane	NN
cord-334133-61om170g	304	17	in	in	IN
cord-334133-61om170g	304	18	the	the	DT
cord-334133-61om170g	304	19	1-MSD	1-msd	CD
cord-334133-61om170g	304	20	model	model	NN
cord-334133-61om170g	304	21	,	,	,
cord-334133-61om170g	304	22	and	and	CC
cord-334133-61om170g	304	23	is	be	VBZ
cord-334133-61om170g	304	24	unlikely	unlikely	JJ
cord-334133-61om170g	304	25	to	to	TO
cord-334133-61om170g	304	26	interact	interact	VB
cord-334133-61om170g	304	27	with	with	IN
cord-334133-61om170g	304	28	AP-1	AP-1	NNP
cord-334133-61om170g	304	29	and	and	CC
cord-334133-61om170g	304	30	AP-3	AP-3	NNP
cord-334133-61om170g	304	31	complexes	complex	NNS
cord-334133-61om170g	304	32	,	,	,
cord-334133-61om170g	304	33	or	or	CC
cord-334133-61om170g	304	34	to	to	TO
cord-334133-61om170g	304	35	be	be	VB
cord-334133-61om170g	304	36	involved	involve	VBN
cord-334133-61om170g	304	37	in	in	IN
cord-334133-61om170g	304	38	lysosomal	lysosomal	JJ
cord-334133-61om170g	304	39	targeting	target	VBG
cord-334133-61om170g	304	40	from	from	IN
cord-334133-61om170g	304	41	the	the	DT
cord-334133-61om170g	304	42	TGN	TGN	NNP
cord-334133-61om170g	304	43	.	.	.
cord-334133-61om170g	305	1	However	however	RB
cord-334133-61om170g	305	2	,	,	,
cord-334133-61om170g	305	3	the	the	DT
cord-334133-61om170g	305	4	Y	Y	NNP
cord-334133-61om170g	305	5	is	be	VBZ
cord-334133-61om170g	305	6	almost	almost	RB
cord-334133-61om170g	305	7	completely	completely	RB
cord-334133-61om170g	305	8	conserved	conserved	JJ
cord-334133-61om170g	305	9	and	and	CC
cord-334133-61om170g	305	10	the	the	DT
cord-334133-61om170g	305	11	bulky	bulky	JJ
cord-334133-61om170g	305	12	hydrophobic	hydrophobic	JJ
cord-334133-61om170g	305	13	residue	residue	NN
cord-334133-61om170g	305	14	is	be	VBZ
cord-334133-61om170g	305	15	highly	highly	RB
cord-334133-61om170g	305	16	conserved	conserve	VBN
cord-334133-61om170g	305	17	.	.	.
cord-334133-61om170g	306	1	In	in	IN
cord-334133-61om170g	306	2	the	the	DT
cord-334133-61om170g	306	3	3-MSD	3-msd	CD
cord-334133-61om170g	306	4	structure	structure	NN
cord-334133-61om170g	306	5	of	of	IN
cord-334133-61om170g	306	6	gp41	gp41	NNP
cord-334133-61om170g	306	7	,	,	,
cord-334133-61om170g	306	8	only	only	RB
cord-334133-61om170g	306	9	the	the	DT
cord-334133-61om170g	306	10	second	second	JJ
cord-334133-61om170g	306	11	signal	signal	NN
cord-334133-61om170g	306	12	is	be	VBZ
cord-334133-61om170g	306	13	on	on	IN
cord-334133-61om170g	306	14	the	the	DT
cord-334133-61om170g	306	15	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	306	16	side	side	NN
cord-334133-61om170g	306	17	of	of	IN
cord-334133-61om170g	306	18	the	the	DT
cord-334133-61om170g	306	19	membrane	membrane	NN
cord-334133-61om170g	306	20	,	,	,
cord-334133-61om170g	306	21	where	where	WRB
cord-334133-61om170g	306	22	it	-PRON-	PRP
cord-334133-61om170g	306	23	could	could	MD
cord-334133-61om170g	306	24	be	be	VB
cord-334133-61om170g	306	25	functional	functional	JJ
cord-334133-61om170g	306	26	.	.	.
cord-334133-61om170g	307	1	In	in	IN
cord-334133-61om170g	307	2	the	the	DT
cord-334133-61om170g	307	3	infected	infected	JJ
cord-334133-61om170g	307	4	cell	cell	NN
cord-334133-61om170g	307	5	there	there	EX
cord-334133-61om170g	307	6	may	may	MD
cord-334133-61om170g	307	7	be	be	VB
cord-334133-61om170g	307	8	populations	population	NNS
cord-334133-61om170g	307	9	of	of	IN
cord-334133-61om170g	307	10	gp41	gp41	NNP
cord-334133-61om170g	307	11	with	with	IN
cord-334133-61om170g	307	12	one	one	CD
cord-334133-61om170g	307	13	MSD	MSD	NNP
cord-334133-61om170g	307	14	and	and	CC
cord-334133-61om170g	307	15	three	three	CD
cord-334133-61om170g	307	16	MSDs	msd	NNS
cord-334133-61om170g	307	17	Until	until	IN
cord-334133-61om170g	307	18	recently	recently	RB
cord-334133-61om170g	307	19	all	all	DT
cord-334133-61om170g	307	20	primate	primate	JJ
cord-334133-61om170g	307	21	lentivirus	lentivirus	NN
cord-334133-61om170g	307	22	envelope	envelope	NN
cord-334133-61om170g	307	23	protein	protein	NN
cord-334133-61om170g	307	24	anchor	anchor	NN
cord-334133-61om170g	307	25	components	component	NNS
cord-334133-61om170g	307	26	were	be	VBD
cord-334133-61om170g	307	27	viewed	view	VBN
cord-334133-61om170g	307	28	as	as	IN
cord-334133-61om170g	307	29	having	have	VBG
cord-334133-61om170g	307	30	a	a	DT
cord-334133-61om170g	307	31	single	single	JJ
cord-334133-61om170g	307	32	MSD	msd	NN
cord-334133-61om170g	307	33	(	(	-LRB-
cord-334133-61om170g	307	34	691	691	CD
cord-334133-61om170g	307	35	-712	-712	NN
cord-334133-61om170g	307	36	in	in	IN
cord-334133-61om170g	307	37	HIV-1	HIV-1	NNP
cord-334133-61om170g	307	38	;	;	:
cord-334133-61om170g	307	39	Fig	Fig	NNP
cord-334133-61om170g	307	40	.	.	.
cord-334133-61om170g	307	41	4a	4a	CD
cord-334133-61om170g	307	42	)	)	-RRB-
cord-334133-61om170g	308	1	(	(	-LRB-
cord-334133-61om170g	308	2	Gallaher	Gallaher	NNP
cord-334133-61om170g	308	3	,	,	,
cord-334133-61om170g	308	4	1987	1987	CD
cord-334133-61om170g	309	1	(	(	-LRB-
cord-334133-61om170g	309	2	Gallaher	Gallaher	NNP
cord-334133-61om170g	309	3	,	,	,
cord-334133-61om170g	309	4	,	,	,
cord-334133-61om170g	309	5	1989	1989	CD
cord-334133-61om170g	309	6	Gonzalez	Gonzalez	NNP
cord-334133-61om170g	309	7	-	-	HYPH
cord-334133-61om170g	309	8	Scarano	Scarano	NNP
cord-334133-61om170g	309	9	et	et	NNP
cord-334133-61om170g	309	10	al	al	NNP
cord-334133-61om170g	309	11	.	.	NNP
cord-334133-61om170g	309	12	,	,	,
cord-334133-61om170g	309	13	1987	1987	CD
cord-334133-61om170g	309	14	;	;	:
cord-334133-61om170g	309	15	Levy	Levy	NNP
cord-334133-61om170g	309	16	,	,	,
cord-334133-61om170g	309	17	1998	1998	CD
cord-334133-61om170g	309	18	;	;	:
cord-334133-61om170g	309	19	White	White	NNP
cord-334133-61om170g	309	20	,	,	,
cord-334133-61om170g	309	21	1990	1990	CD
cord-334133-61om170g	309	22	)	)	-RRB-
cord-334133-61om170g	309	23	.	.	.
cord-334133-61om170g	310	1	However	however	RB
cord-334133-61om170g	310	2	,	,	,
cord-334133-61om170g	310	3	published	publish	VBN
cord-334133-61om170g	310	4	work	work	NN
cord-334133-61om170g	310	5	and	and	CC
cord-334133-61om170g	310	6	the	the	DT
cord-334133-61om170g	310	7	discussion	discussion	NN
cord-334133-61om170g	310	8	above	above	IN
cord-334133-61om170g	310	9	suggest	suggest	VBP
cord-334133-61om170g	310	10	that	that	IN
cord-334133-61om170g	310	11	the	the	DT
cord-334133-61om170g	310	12	gp41	gp41	NNP
cord-334133-61om170g	310	13	tail	tail	NN
cord-334133-61om170g	310	14	crosses	cross	VBZ
cord-334133-61om170g	310	15	the	the	DT
cord-334133-61om170g	310	16	membranes	membrane	NNS
cord-334133-61om170g	310	17	of	of	IN
cord-334133-61om170g	310	18	HIV-1	HIV-1	NNP
cord-334133-61om170g	310	19	virions	virion	NNS
cord-334133-61om170g	310	20	and	and	CC
cord-334133-61om170g	310	21	infected	infected	JJ
cord-334133-61om170g	310	22	cells	cell	NNS
cord-334133-61om170g	310	23	three	three	CD
cord-334133-61om170g	310	24	times	time	NNS
cord-334133-61om170g	311	1	(	(	-LRB-
cord-334133-61om170g	311	2	Cheung	Cheung	NNP
cord-334133-61om170g	311	3	et	et	NNP
cord-334133-61om170g	311	4	al	al	NNP
cord-334133-61om170g	311	5	.	.	NNP
cord-334133-61om170g	311	6	,	,	,
cord-334133-61om170g	311	7	2005	2005	CD
cord-334133-61om170g	312	1	;	;	:
cord-334133-61om170g	312	2	Cleveland	Cleveland	NNP
cord-334133-61om170g	312	3	et	et	NNP
cord-334133-61om170g	312	4	al	al	NNP
cord-334133-61om170g	312	5	.	.	NNP
cord-334133-61om170g	312	6	,	,	,
cord-334133-61om170g	312	7	2003	2003	CD
cord-334133-61om170g	312	8	;	;	:
cord-334133-61om170g	312	9	McLain	McLain	NNP
cord-334133-61om170g	312	10	et	et	NNP
cord-334133-61om170g	312	11	al	al	NNP
cord-334133-61om170g	312	12	.	.	NNP
cord-334133-61om170g	312	13	,	,	,
cord-334133-61om170g	312	14	2001	2001	CD
cord-334133-61om170g	312	15	)	)	-RRB-
cord-334133-61om170g	312	16	.	.	.
cord-334133-61om170g	313	1	To	to	TO
cord-334133-61om170g	313	2	resolve	resolve	VB
cord-334133-61om170g	313	3	this	this	DT
cord-334133-61om170g	313	4	apparent	apparent	JJ
cord-334133-61om170g	313	5	conflict	conflict	NN
cord-334133-61om170g	313	6	,	,	,
cord-334133-61om170g	313	7	we	-PRON-	PRP
cord-334133-61om170g	313	8	shall	shall	MD
cord-334133-61om170g	313	9	argue	argue	VB
cord-334133-61om170g	313	10	here	here	RB
cord-334133-61om170g	313	11	that	that	IN
cord-334133-61om170g	313	12	the	the	DT
cord-334133-61om170g	313	13	1-and	1-and	CD
cord-334133-61om170g	313	14	3-MSD	3-msd	CD
cord-334133-61om170g	313	15	forms	form	NNS
cord-334133-61om170g	313	16	of	of	IN
cord-334133-61om170g	313	17	gp41	gp41	NNP
cord-334133-61om170g	313	18	coexist	coexist	VBP
cord-334133-61om170g	313	19	in	in	IN
cord-334133-61om170g	313	20	the	the	DT
cord-334133-61om170g	313	21	infected	infected	JJ
cord-334133-61om170g	313	22	cell	cell	NN
cord-334133-61om170g	313	23	,	,	,
cord-334133-61om170g	313	24	with	with	IN
cord-334133-61om170g	313	25	the	the	DT
cord-334133-61om170g	313	26	1-MSD	1-msd	CD
cord-334133-61om170g	313	27	version	version	NN
cord-334133-61om170g	313	28	being	be	VBG
cord-334133-61om170g	313	29	the	the	DT
cord-334133-61om170g	313	30	major	major	JJ
cord-334133-61om170g	313	31	form	form	NN
cord-334133-61om170g	313	32	.	.	.
cord-334133-61om170g	314	1	However	however	RB
cord-334133-61om170g	314	2	,	,	,
cord-334133-61om170g	314	3	we	-PRON-	PRP
cord-334133-61om170g	314	4	shall	shall	MD
cord-334133-61om170g	314	5	propose	propose	VB
cord-334133-61om170g	314	6	that	that	IN
cord-334133-61om170g	314	7	only	only	RB
cord-334133-61om170g	314	8	the	the	DT
cord-334133-61om170g	314	9	minor	minor	JJ
cord-334133-61om170g	314	10	3-MSD	3-msd	CD
cord-334133-61om170g	314	11	form	form	NN
cord-334133-61om170g	314	12	is	be	VBZ
cord-334133-61om170g	314	13	incorporated	incorporate	VBN
cord-334133-61om170g	314	14	into	into	IN
cord-334133-61om170g	314	15	virions	virion	NNS
cord-334133-61om170g	314	16	.	.	.
cord-334133-61om170g	315	1	These	these	DT
cord-334133-61om170g	315	2	proposals	proposal	NNS
cord-334133-61om170g	315	3	are	be	VBP
cord-334133-61om170g	315	4	consistent	consistent	JJ
cord-334133-61om170g	315	5	with	with	IN
cord-334133-61om170g	315	6	,	,	,
cord-334133-61om170g	315	7	and	and	CC
cord-334133-61om170g	315	8	rationalize	rationalize	VB
cord-334133-61om170g	315	9	the	the	DT
cord-334133-61om170g	315	10	observed	observed	JJ
cord-334133-61om170g	315	11	degradation	degradation	NN
cord-334133-61om170g	315	12	of	of	IN
cord-334133-61om170g	315	13	the	the	DT
cord-334133-61om170g	315	14	majority	majority	NN
cord-334133-61om170g	315	15	(	(	-LRB-
cord-334133-61om170g	315	16	85	85	CD
cord-334133-61om170g	315	17	-95	-95	NN
cord-334133-61om170g	315	18	%	%	NN
cord-334133-61om170g	315	19	)	)	-RRB-
cord-334133-61om170g	315	20	of	of	IN
cord-334133-61om170g	315	21	the1-MSD	the1-msd	CD
cord-334133-61om170g	315	22	form	form	NN
cord-334133-61om170g	315	23	of	of	IN
cord-334133-61om170g	315	24	cellular	cellular	JJ
cord-334133-61om170g	315	25	gp160	gp160	NN
cord-334133-61om170g	316	1	(	(	-LRB-
cord-334133-61om170g	316	2	Bultmann	Bultmann	NNP
cord-334133-61om170g	316	3	et	et	NNP
cord-334133-61om170g	316	4	al	al	NNP
cord-334133-61om170g	316	5	.	.	NNP
cord-334133-61om170g	316	6	,	,	,
cord-334133-61om170g	316	7	2000	2000	CD
cord-334133-61om170g	316	8	;	;	:
cord-334133-61om170g	316	9	Courageot	Courageot	NNP
cord-334133-61om170g	316	10	et	et	NNP
cord-334133-61om170g	316	11	al	al	NNP
cord-334133-61om170g	316	12	.	.	NNP
cord-334133-61om170g	316	13	,	,	,
cord-334133-61om170g	316	14	1999	1999	CD
cord-334133-61om170g	316	15	;	;	:
cord-334133-61om170g	316	16	Jabbar	Jabbar	NNP
cord-334133-61om170g	316	17	and	and	CC
cord-334133-61om170g	316	18	Nayak	Nayak	NNP
cord-334133-61om170g	316	19	,	,	,
cord-334133-61om170g	316	20	1990	1990	CD
cord-334133-61om170g	316	21	;	;	:
cord-334133-61om170g	317	1	Pfeiffer	Pfeiffer	NNP
cord-334133-61om170g	317	2	et	et	NNP
cord-334133-61om170g	317	3	al	al	NNP
cord-334133-61om170g	317	4	.	.	NNP
cord-334133-61om170g	317	5	,	,	,
cord-334133-61om170g	317	6	1997	1997	CD
cord-334133-61om170g	317	7	;	;	:
cord-334133-61om170g	317	8	Willey	Willey	NNP
cord-334133-61om170g	317	9	et	et	NNP
cord-334133-61om170g	317	10	al	al	NNP
cord-334133-61om170g	317	11	.	.	NNP
cord-334133-61om170g	317	12	,	,	,
cord-334133-61om170g	317	13	1988	1988	CD
cord-334133-61om170g	317	14	)	)	-RRB-
cord-334133-61om170g	317	15	,	,	,
cord-334133-61om170g	317	16	the	the	DT
cord-334133-61om170g	317	17	apparently	apparently	RB
cord-334133-61om170g	317	18	contradictory	contradictory	JJ
cord-334133-61om170g	317	19	evidence	evidence	NN
cord-334133-61om170g	317	20	of	of	IN
cord-334133-61om170g	317	21	a	a	DT
cord-334133-61om170g	317	22	functioning	function	VBG
cord-334133-61om170g	317	23	first	first	JJ
cord-334133-61om170g	317	24	tyrosine	tyrosine	NN
cord-334133-61om170g	317	25	-	-	HYPH
cord-334133-61om170g	317	26	sorting	sort	VBG
cord-334133-61om170g	317	27	signal	signal	NN
cord-334133-61om170g	317	28	(	(	-LRB-
cord-334133-61om170g	317	29	Berlioz	Berlioz	NNP
cord-334133-61om170g	317	30	-	-	HYPH
cord-334133-61om170g	317	31	Torrent	Torrent	NNP
cord-334133-61om170g	317	32	et	et	FW
cord-334133-61om170g	317	33	al	al	NNP
cord-334133-61om170g	317	34	.	.	.
cord-334133-61om170g	318	1	,	,	,
cord-334133-61om170g	318	2	1999	1999	CD
cord-334133-61om170g	318	3	;	;	:
cord-334133-61om170g	318	4	Boge	Boge	NNP
cord-334133-61om170g	318	5	et	et	NNP
cord-334133-61om170g	318	6	al	al	NNP
cord-334133-61om170g	318	7	.	.	NNP
cord-334133-61om170g	318	8	,	,	,
cord-334133-61om170g	318	9	1998	1998	CD
cord-334133-61om170g	318	10	;	;	:
cord-334133-61om170g	319	1	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	319	2	et	et	FW
cord-334133-61om170g	319	3	al	al	NNP
cord-334133-61om170g	319	4	.	.	NNP
cord-334133-61om170g	319	5	,	,	,
cord-334133-61om170g	319	6	1999	1999	CD
cord-334133-61om170g	319	7	;	;	:
cord-334133-61om170g	319	8	Egan	Egan	NNP
cord-334133-61om170g	319	9	et	et	NNP
cord-334133-61om170g	319	10	al	al	NNP
cord-334133-61om170g	319	11	.	.	.
cord-334133-61om170g	320	1	,	,	,
cord-334133-61om170g	320	2	1996	1996	CD
cord-334133-61om170g	320	3	;	;	:
cord-334133-61om170g	320	4	Ohno	Ohno	NNP
cord-334133-61om170g	320	5	et	et	NNP
cord-334133-61om170g	320	6	al	al	NNP
cord-334133-61om170g	320	7	.	.	NNP
cord-334133-61om170g	320	8	,	,	,
cord-334133-61om170g	320	9	1997	1997	CD
cord-334133-61om170g	320	10	;	;	:
cord-334133-61om170g	320	11	Rowell	Rowell	NNP
cord-334133-61om170g	320	12	et	et	NNP
cord-334133-61om170g	320	13	al	al	NNP
cord-334133-61om170g	320	14	.	.	NNP
cord-334133-61om170g	320	15	,	,	,
cord-334133-61om170g	320	16	1995	1995	CD
cord-334133-61om170g	321	1	;	;	:
cord-334133-61om170g	321	2	West	West	NNP
cord-334133-61om170g	321	3	et	et	NNP
cord-334133-61om170g	321	4	al	al	NNP
cord-334133-61om170g	321	5	.	.	NNP
cord-334133-61om170g	321	6	,	,	,
cord-334133-61om170g	321	7	2002	2002	CD
cord-334133-61om170g	321	8	)	)	-RRB-
cord-334133-61om170g	321	9	and	and	CC
cord-334133-61om170g	321	10	basolateral	basolateral	JJ
cord-334133-61om170g	321	11	-	-	HYPH
cord-334133-61om170g	321	12	sorting	sort	VBG
cord-334133-61om170g	321	13	signal	signal	NN
cord-334133-61om170g	322	1	(	(	-LRB-
cord-334133-61om170g	322	2	Deschambeault	Deschambeault	NNP
cord-334133-61om170g	322	3	et	et	FW
cord-334133-61om170g	322	4	al	al	NNP
cord-334133-61om170g	322	5	.	.	.
cord-334133-61om170g	323	1	,	,	,
cord-334133-61om170g	323	2	1999	1999	CD
cord-334133-61om170g	323	3	;	;	:
cord-334133-61om170g	323	4	Lodge	Lodge	NNP
cord-334133-61om170g	323	5	et	et	NNP
cord-334133-61om170g	323	6	al	al	NNP
cord-334133-61om170g	323	7	.	.	NNP
cord-334133-61om170g	323	8	,	,	,
cord-334133-61om170g	323	9	1997	1997	CD
cord-334133-61om170g	323	10	;	;	:
cord-334133-61om170g	323	11	Owens	Owens	NNP
cord-334133-61om170g	323	12	et	et	NNP
cord-334133-61om170g	323	13	al	al	NNP
cord-334133-61om170g	323	14	.	.	NNP
cord-334133-61om170g	323	15	,	,	,
cord-334133-61om170g	323	16	1991	1991	CD
cord-334133-61om170g	323	17	)	)	-RRB-
cord-334133-61om170g	323	18	,	,	,
cord-334133-61om170g	323	19	with	with	IN
cord-334133-61om170g	323	20	the	the	DT
cord-334133-61om170g	323	21	immunogenic	immunogenic	JJ
cord-334133-61om170g	323	22	and	and	CC
cord-334133-61om170g	323	23	antigenic	antigenic	JJ
cord-334133-61om170g	323	24	properties	property	NNS
cord-334133-61om170g	323	25	of	of	IN
cord-334133-61om170g	323	26	the	the	DT
cord-334133-61om170g	323	27	Kennedy	Kennedy	NNP
cord-334133-61om170g	323	28	region	region	NN
cord-334133-61om170g	323	29	(	(	-LRB-
cord-334133-61om170g	323	30	Chanh	Chanh	NNP
cord-334133-61om170g	323	31	et	et	NNP
cord-334133-61om170g	323	32	al	al	NNP
cord-334133-61om170g	323	33	.	.	.
cord-334133-61om170g	324	1	,	,	,
cord-334133-61om170g	324	2	1986	1986	CD
cord-334133-61om170g	324	3	;	;	:
cord-334133-61om170g	324	4	Dalgleish	Dalgleish	NNP
cord-334133-61om170g	324	5	et	et	FW
cord-334133-61om170g	324	6	al	al	NNP
cord-334133-61om170g	324	7	.	.	NNP
cord-334133-61om170g	324	8	,	,	,
cord-334133-61om170g	324	9	1988	1988	CD
cord-334133-61om170g	324	10	;	;	.
cord-334133-61om170g	325	1	Evans	Evans	NNP
cord-334133-61om170g	325	2	et	et	NNP
cord-334133-61om170g	325	3	al	al	NNP
cord-334133-61om170g	325	4	.	.	NNP
cord-334133-61om170g	325	5	,	,	,
cord-334133-61om170g	325	6	1989	1989	CD
cord-334133-61om170g	325	7	;	;	:
cord-334133-61om170g	326	1	Ho	Ho	NNP
cord-334133-61om170g	326	2	et	et	FW
cord-334133-61om170g	326	3	al	al	NNP
cord-334133-61om170g	326	4	.	.	NNP
cord-334133-61om170g	326	5	,	,	,
cord-334133-61om170g	326	6	1987	1987	CD
cord-334133-61om170g	326	7	;	;	:
cord-334133-61om170g	326	8	Kennedy	Kennedy	NNP
cord-334133-61om170g	326	9	et	et	NNP
cord-334133-61om170g	326	10	al	al	NNP
cord-334133-61om170g	326	11	.	.	NNP
cord-334133-61om170g	326	12	,	,	,
cord-334133-61om170g	326	13	1986	1986	CD
cord-334133-61om170g	327	1	;	;	:
cord-334133-61om170g	327	2	Niedrig	Niedrig	NNP
cord-334133-61om170g	327	3	et	et	NNP
cord-334133-61om170g	327	4	al	al	NNP
cord-334133-61om170g	327	5	.	.	NNP
cord-334133-61om170g	327	6	,	,	,
cord-334133-61om170g	327	7	1992	1992	CD
cord-334133-61om170g	327	8	)	)	-RRB-
cord-334133-61om170g	327	9	.	.	.
cord-334133-61om170g	328	1	The	the	DT
cord-334133-61om170g	328	2	C	c	NN
cord-334133-61om170g	328	3	-	-	HYPH
cord-334133-61om170g	328	4	terminal	terminal	NN
cord-334133-61om170g	328	5	tail	tail	NN
cord-334133-61om170g	328	6	of	of	IN
cord-334133-61om170g	328	7	the	the	DT
cord-334133-61om170g	328	8	1-MSD	1-msd	CD
cord-334133-61om170g	328	9	form	form	NN
cord-334133-61om170g	328	10	of	of	IN
cord-334133-61om170g	328	11	HIV-1	HIV-1	NNP
cord-334133-61om170g	328	12	gp41	gp41	NNP
cord-334133-61om170g	328	13	starts	start	VBZ
cord-334133-61om170g	328	14	at	at	IN
cord-334133-61om170g	328	15	residue	residue	NN
cord-334133-61om170g	328	16	713	713	CD
cord-334133-61om170g	328	17	(	(	-LRB-
cord-334133-61om170g	328	18	Fig	Fig	NNP
cord-334133-61om170g	328	19	.	.	.
cord-334133-61om170g	328	20	4a	4a	CD
cord-334133-61om170g	328	21	)	)	-RRB-
cord-334133-61om170g	328	22	.	.	.
cord-334133-61om170g	329	1	As	as	IN
cord-334133-61om170g	329	2	already	already	RB
cord-334133-61om170g	329	3	stated	state	VBN
cord-334133-61om170g	329	4	,	,	,
cord-334133-61om170g	329	5	the	the	DT
cord-334133-61om170g	329	6	majority	majority	NN
cord-334133-61om170g	329	7	of	of	IN
cord-334133-61om170g	329	8	this	this	DT
cord-334133-61om170g	329	9	type	type	NN
cord-334133-61om170g	329	10	of	of	IN
cord-334133-61om170g	329	11	gp41	gp41	NN
cord-334133-61om170g	329	12	(	(	-LRB-
cord-334133-61om170g	329	13	85	85	CD
cord-334133-61om170g	329	14	-95	-95	NN
cord-334133-61om170g	329	15	%	%	NN
cord-334133-61om170g	329	16	)	)	-RRB-
cord-334133-61om170g	329	17	is	be	VBZ
cord-334133-61om170g	329	18	degraded	degrade	VBN
cord-334133-61om170g	329	19	intracellularly	intracellularly	RB
cord-334133-61om170g	329	20	.	.	.
cord-334133-61om170g	330	1	The	the	DT
cord-334133-61om170g	330	2	Y	Y	NNP
cord-334133-61om170g	330	3	residue	residue	NN
cord-334133-61om170g	330	4	of	of	IN
cord-334133-61om170g	330	5	the	the	DT
cord-334133-61om170g	330	6	first	first	JJ
cord-334133-61om170g	330	7	tyrosine	tyrosine	NN
cord-334133-61om170g	330	8	-	-	HYPH
cord-334133-61om170g	330	9	dependent	dependent	JJ
cord-334133-61om170g	330	10	sorting	sorting	NN
cord-334133-61om170g	330	11	signal	signal	NN
cord-334133-61om170g	330	12	(	(	-LRB-
cord-334133-61om170g	330	13	718	718	CD
cord-334133-61om170g	330	14	GYSPL	GYSPL	NNP
cord-334133-61om170g	330	15	722	722	CD
cord-334133-61om170g	330	16	)	)	-RRB-
cord-334133-61om170g	330	17	is	be	VBZ
cord-334133-61om170g	330	18	situated	situate	VBN
cord-334133-61om170g	330	19	precisely	precisely	RB
cord-334133-61om170g	330	20	7	7	CD
cord-334133-61om170g	330	21	residues	residue	NNS
cord-334133-61om170g	330	22	from	from	IN
cord-334133-61om170g	330	23	the	the	DT
cord-334133-61om170g	330	24	membrane	membrane	NN
cord-334133-61om170g	330	25	and	and	CC
cord-334133-61om170g	330	26	conforms	conform	VBZ
cord-334133-61om170g	330	27	closely	closely	RB
cord-334133-61om170g	330	28	to	to	IN
cord-334133-61om170g	330	29	the	the	DT
cord-334133-61om170g	330	30	requirements	requirement	NNS
cord-334133-61om170g	330	31	for	for	IN
cord-334133-61om170g	330	32	cellular	cellular	JJ
cord-334133-61om170g	330	33	GYxxf	gyxxf	IN
cord-334133-61om170g	330	34	lysosomal	lysosomal	JJ
cord-334133-61om170g	330	35	targeting	targeting	NN
cord-334133-61om170g	330	36	signals	signal	NNS
cord-334133-61om170g	330	37	(	(	-LRB-
cord-334133-61om170g	330	38	see	see	VB
cord-334133-61om170g	330	39	above	above	RB
cord-334133-61om170g	330	40	)	)	-RRB-
cord-334133-61om170g	330	41	.	.	.
cord-334133-61om170g	331	1	In	in	IN
cord-334133-61om170g	331	2	the	the	DT
cord-334133-61om170g	331	3	1-MSD	1-msd	CD
cord-334133-61om170g	331	4	form	form	NN
cord-334133-61om170g	331	5	of	of	IN
cord-334133-61om170g	331	6	gp41	gp41	NNP
cord-334133-61om170g	331	7	,	,	,
cord-334133-61om170g	331	8	the	the	DT
cord-334133-61om170g	331	9	second	second	JJ
cord-334133-61om170g	331	10	tyrosinedependent	tyrosinedependent	NN
cord-334133-61om170g	331	11	sorting	sorting	NN
cord-334133-61om170g	331	12	signal	signal	NN
cord-334133-61om170g	331	13	is	be	VBZ
cord-334133-61om170g	331	14	apparently	apparently	RB
cord-334133-61om170g	331	15	not	not	RB
cord-334133-61om170g	331	16	needed	need	VBN
cord-334133-61om170g	331	17	,	,	,
cord-334133-61om170g	331	18	and	and	CC
cord-334133-61om170g	331	19	we	-PRON-	PRP
cord-334133-61om170g	331	20	suggest	suggest	VBP
cord-334133-61om170g	331	21	may	may	MD
cord-334133-61om170g	331	22	not	not	RB
cord-334133-61om170g	331	23	be	be	VB
cord-334133-61om170g	331	24	functional	functional	JJ
cord-334133-61om170g	331	25	.	.	.
cord-334133-61om170g	332	1	The	the	DT
cord-334133-61om170g	332	2	3-MSD	3-msd	CD
cord-334133-61om170g	332	3	form	form	NN
cord-334133-61om170g	332	4	of	of	IN
cord-334133-61om170g	332	5	HIV-1	HIV-1	NNP
cord-334133-61om170g	332	6	gp41	gp41	NNP
cord-334133-61om170g	332	7	has	have	VBZ
cord-334133-61om170g	332	8	MSDs	msd	NNS
cord-334133-61om170g	332	9	at	at	IN
cord-334133-61om170g	332	10	691	691	CD
cord-334133-61om170g	332	11	-	-	SYM
cord-334133-61om170g	332	12	700	700	CD
cord-334133-61om170g	332	13	,	,	,
cord-334133-61om170g	332	14	703	703	CD
cord-334133-61om170g	332	15	-	-	SYM
cord-334133-61om170g	332	16	712	712	CD
cord-334133-61om170g	332	17	,	,	,
cord-334133-61om170g	332	18	and	and	CC
cord-334133-61om170g	332	19	754	754	CD
cord-334133-61om170g	332	20	-763	-763	NN
cord-334133-61om170g	332	21	,	,	,
cord-334133-61om170g	332	22	and	and	CC
cord-334133-61om170g	332	23	its	-PRON-	PRP$
cord-334133-61om170g	332	24	718	718	CD
cord-334133-61om170g	332	25	GYSPL	GYSPL	NNP
cord-334133-61om170g	332	26	722	722	CD
cord-334133-61om170g	332	27	sequence	sequence	NN
cord-334133-61om170g	332	28	is	be	VBZ
cord-334133-61om170g	332	29	outside	outside	IN
cord-334133-61om170g	332	30	the	the	DT
cord-334133-61om170g	332	31	virion	virion	NN
cord-334133-61om170g	332	32	.	.	.
cord-334133-61om170g	333	1	This	this	DT
cord-334133-61om170g	333	2	model	model	NN
cord-334133-61om170g	333	3	is	be	VBZ
cord-334133-61om170g	333	4	supported	support	VBN
cord-334133-61om170g	333	5	by	by	IN
cord-334133-61om170g	333	6	antigenic	antigenic	JJ
cord-334133-61om170g	333	7	and	and	CC
cord-334133-61om170g	333	8	other	other	JJ
cord-334133-61om170g	333	9	data	datum	NNS
cord-334133-61om170g	333	10	showing	show	VBG
cord-334133-61om170g	333	11	that	that	IN
cord-334133-61om170g	333	12	residues	residue	NNS
cord-334133-61om170g	333	13	of	of	IN
cord-334133-61om170g	333	14	the	the	DT
cord-334133-61om170g	333	15	C	C	NNP
cord-334133-61om170g	333	16	-	-	HYPH
cord-334133-61om170g	333	17	terminal	terminal	NN
cord-334133-61om170g	333	18	tail	tail	NN
cord-334133-61om170g	333	19	are	be	VBP
cord-334133-61om170g	333	20	exposed	expose	VBN
cord-334133-61om170g	333	21	on	on	IN
cord-334133-61om170g	333	22	the	the	DT
cord-334133-61om170g	333	23	surface	surface	NN
cord-334133-61om170g	333	24	of	of	IN
cord-334133-61om170g	333	25	the	the	DT
cord-334133-61om170g	333	26	virion	virion	NN
cord-334133-61om170g	334	1	(	(	-LRB-
cord-334133-61om170g	334	2	Buratti	Buratti	NNP
cord-334133-61om170g	334	3	et	et	NNP
cord-334133-61om170g	334	4	al	al	NNP
cord-334133-61om170g	334	5	.	.	.
cord-334133-61om170g	335	1	,	,	,
cord-334133-61om170g	335	2	1998	1998	CD
cord-334133-61om170g	335	3	;	;	:
cord-334133-61om170g	335	4	Chanh	Chanh	NNP
cord-334133-61om170g	335	5	et	et	NNP
cord-334133-61om170g	335	6	al	al	NNP
cord-334133-61om170g	335	7	.	.	NNP
cord-334133-61om170g	335	8	,	,	,
cord-334133-61om170g	335	9	1986	1986	CD
cord-334133-61om170g	335	10	;	;	:
cord-334133-61om170g	335	11	Cleveland	Cleveland	NNP
cord-334133-61om170g	335	12	et	et	NNP
cord-334133-61om170g	335	13	al	al	NNP
cord-334133-61om170g	335	14	.	.	.
cord-334133-61om170g	336	1	,	,	,
cord-334133-61om170g	336	2	2000a	2000a	CD
cord-334133-61om170g	337	1	Cleveland	Cleveland	NNP
cord-334133-61om170g	337	2	et	et	NNP
cord-334133-61om170g	337	3	al	al	NNP
cord-334133-61om170g	337	4	.	.	.
cord-334133-61om170g	338	1	,	,	,
cord-334133-61om170g	338	2	,	,	,
cord-334133-61om170g	338	3	b,2003	b,2003	NN
cord-334133-61om170g	338	4	Dalgleish	Dalgleish	NNP
cord-334133-61om170g	338	5	et	et	FW
cord-334133-61om170g	338	6	al	al	NNP
cord-334133-61om170g	338	7	.	.	NNP
cord-334133-61om170g	338	8	,	,	,
cord-334133-61om170g	338	9	1988	1988	CD
cord-334133-61om170g	338	10	;	;	:
cord-334133-61om170g	338	11	Durrani	Durrani	NNP
cord-334133-61om170g	338	12	et	et	NNP
cord-334133-61om170g	338	13	al	al	NNP
cord-334133-61om170g	338	14	.	.	NNP
cord-334133-61om170g	338	15	,	,	,
cord-334133-61om170g	338	16	1998	1998	CD
cord-334133-61om170g	338	17	;	;	:
cord-334133-61om170g	339	1	Ho	Ho	NNP
cord-334133-61om170g	339	2	et	et	FW
cord-334133-61om170g	339	3	al	al	NNP
cord-334133-61om170g	339	4	.	.	NNP
cord-334133-61om170g	339	5	,	,	,
cord-334133-61om170g	339	6	1987	1987	CD
cord-334133-61om170g	339	7	;	;	:
cord-334133-61om170g	339	8	McInerney	McInerney	NNP
cord-334133-61om170g	339	9	et	et	NNP
cord-334133-61om170g	339	10	al	al	NNP
cord-334133-61om170g	339	11	.	.	NNP
cord-334133-61om170g	339	12	,	,	,
cord-334133-61om170g	339	13	1999	1999	CD
cord-334133-61om170g	340	1	;	;	:
cord-334133-61om170g	340	2	McLain	McLain	NNP
cord-334133-61om170g	340	3	et	et	NNP
cord-334133-61om170g	340	4	al	al	NNP
cord-334133-61om170g	340	5	.	.	.
cord-334133-61om170g	341	1	,	,	,
cord-334133-61om170g	341	2	1995	1995	CD
cord-334133-61om170g	342	1	McLain	McLain	NNP
cord-334133-61om170g	342	2	et	et	NNP
cord-334133-61om170g	342	3	al	al	NNP
cord-334133-61om170g	342	4	.	.	.
cord-334133-61om170g	343	1	,	,	,
cord-334133-61om170g	343	2	,	,	,
cord-334133-61om170g	343	3	1996	1996	CD
cord-334133-61om170g	343	4	McLain	McLain	NNP
cord-334133-61om170g	343	5	et	et	NNP
cord-334133-61om170g	343	6	al	al	NNP
cord-334133-61om170g	343	7	.	.	.
cord-334133-61om170g	344	1	,	,	,
cord-334133-61om170g	344	2	,	,	,
cord-334133-61om170g	344	3	2001	2001	CD
cord-334133-61om170g	344	4	Newton	Newton	NNP
cord-334133-61om170g	344	5	et	et	NNP
cord-334133-61om170g	344	6	al	al	NNP
cord-334133-61om170g	344	7	.	.	NNP
cord-334133-61om170g	344	8	,	,	,
cord-334133-61om170g	344	9	1995	1995	CD
cord-334133-61om170g	344	10	;	;	:
cord-334133-61om170g	344	11	Reading	read	VBG
cord-334133-61om170g	344	12	et	et	FW
cord-334133-61om170g	344	13	al	al	NNP
cord-334133-61om170g	344	14	.	.	NNP
cord-334133-61om170g	344	15	,	,	,
cord-334133-61om170g	344	16	2003	2003	CD
cord-334133-61om170g	344	17	)	)	-RRB-
cord-334133-61om170g	344	18	and	and	CC
cord-334133-61om170g	344	19	the	the	DT
cord-334133-61om170g	344	20	infected	infected	JJ
cord-334133-61om170g	344	21	cell	cell	NN
cord-334133-61om170g	344	22	(	(	-LRB-
cord-334133-61om170g	344	23	Cheung	Cheung	NNP
cord-334133-61om170g	344	24	et	et	NNP
cord-334133-61om170g	344	25	al	al	NNP
cord-334133-61om170g	344	26	.	.	NNP
cord-334133-61om170g	344	27	,	,	,
cord-334133-61om170g	344	28	2005	2005	CD
cord-334133-61om170g	344	29	;	;	:
cord-334133-61om170g	344	30	Heap	Heap	NNP
cord-334133-61om170g	344	31	et	et	NNP
cord-334133-61om170g	344	32	al	al	NNP
cord-334133-61om170g	344	33	.	.	NNP
cord-334133-61om170g	344	34	,	,	,
cord-334133-61om170g	344	35	2005	2005	CD
cord-334133-61om170g	344	36	)	)	-RRB-
cord-334133-61om170g	344	37	.	.	.
cord-334133-61om170g	345	1	Furthermore	furthermore	RB
cord-334133-61om170g	345	2	,	,	,
cord-334133-61om170g	345	3	we	-PRON-	PRP
cord-334133-61om170g	345	4	propose	propose	VBP
cord-334133-61om170g	345	5	that	that	IN
cord-334133-61om170g	345	6	this	this	DT
cord-334133-61om170g	345	7	form	form	NN
cord-334133-61om170g	345	8	of	of	IN
cord-334133-61om170g	345	9	gp41	gp41	NNP
cord-334133-61om170g	345	10	represents	represent	VBZ
cord-334133-61om170g	345	11	the	the	DT
cord-334133-61om170g	345	12	5	5	CD
cord-334133-61om170g	345	13	-15	-15	CD
cord-334133-61om170g	345	14	%	%	NN
cord-334133-61om170g	345	15	of	of	IN
cord-334133-61om170g	345	16	the	the	DT
cord-334133-61om170g	345	17	TGN	TGN	NNP
cord-334133-61om170g	345	18	gp160	gp160	NNP
cord-334133-61om170g	345	19	that	that	WDT
cord-334133-61om170g	345	20	is	be	VBZ
cord-334133-61om170g	345	21	directed	direct	VBN
cord-334133-61om170g	345	22	to	to	IN
cord-334133-61om170g	345	23	the	the	DT
cord-334133-61om170g	345	24	cell	cell	NN
cord-334133-61om170g	345	25	surface	surface	NN
cord-334133-61om170g	345	26	.	.	.
cord-334133-61om170g	346	1	Its	-PRON-	PRP$
cord-334133-61om170g	346	2	GYxxf	GYxxf	NNP
cord-334133-61om170g	346	3	signal	signal	NN
cord-334133-61om170g	346	4	is	be	VBZ
cord-334133-61om170g	346	5	outside	outside	IN
cord-334133-61om170g	346	6	the	the	DT
cord-334133-61om170g	346	7	cell	cell	NN
cord-334133-61om170g	346	8	membrane	membrane	NN
cord-334133-61om170g	346	9	and	and	CC
cord-334133-61om170g	346	10	can	can	MD
cord-334133-61om170g	346	11	not	not	RB
cord-334133-61om170g	346	12	function	function	VB
cord-334133-61om170g	346	13	in	in	IN
cord-334133-61om170g	346	14	lysosomal	lysosomal	JJ
cord-334133-61om170g	346	15	targeting	targeting	NN
cord-334133-61om170g	346	16	or	or	CC
cord-334133-61om170g	346	17	endocytosis	endocytosis	NN
cord-334133-61om170g	346	18	,	,	,
cord-334133-61om170g	346	19	but	but	CC
cord-334133-61om170g	346	20	the	the	DT
cord-334133-61om170g	346	21	second	second	JJ
cord-334133-61om170g	346	22	potential	potential	JJ
cord-334133-61om170g	346	23	tyrosine	tyrosine	NN
cord-334133-61om170g	346	24	-	-	HYPH
cord-334133-61om170g	346	25	dependent	dependent	JJ
cord-334133-61om170g	346	26	sorting	sorting	NN
cord-334133-61om170g	346	27	signal	signal	NN
cord-334133-61om170g	346	28	(	(	-LRB-
cord-334133-61om170g	346	29	775	775	CD
cord-334133-61om170g	346	30	YHRL	YHRL	NNP
cord-334133-61om170g	346	31	778	778	CD
cord-334133-61om170g	346	32	)	)	-RRB-
cord-334133-61om170g	346	33	,	,	,
cord-334133-61om170g	346	34	which	which	WDT
cord-334133-61om170g	346	35	has	have	VBZ
cord-334133-61om170g	346	36	none	none	NN
cord-334133-61om170g	346	37	of	of	IN
cord-334133-61om170g	346	38	the	the	DT
cord-334133-61om170g	346	39	requirements	requirement	NNS
cord-334133-61om170g	346	40	for	for	IN
cord-334133-61om170g	346	41	lysosomal	lysosomal	NN
cord-334133-61om170g	346	42	targeting	targeting	NN
cord-334133-61om170g	346	43	(	(	-LRB-
cord-334133-61om170g	346	44	see	see	VB
cord-334133-61om170g	346	45	above	above	RB
cord-334133-61om170g	346	46	)	)	-RRB-
cord-334133-61om170g	346	47	,	,	,
cord-334133-61om170g	346	48	is	be	VBZ
cord-334133-61om170g	346	49	12	12	CD
cord-334133-61om170g	346	50	residues	residue	NNS
cord-334133-61om170g	346	51	from	from	IN
cord-334133-61om170g	346	52	the	the	DT
cord-334133-61om170g	346	53	membrane	membrane	NN
cord-334133-61om170g	346	54	,	,	,
cord-334133-61om170g	346	55	and	and	CC
cord-334133-61om170g	346	56	well	well	RB
cord-334133-61om170g	346	57	situated	situated	JJ
cord-334133-61om170g	346	58	to	to	TO
cord-334133-61om170g	346	59	function	function	VB
cord-334133-61om170g	346	60	in	in	IN
cord-334133-61om170g	346	61	endocytosis	endocytosis	NN
cord-334133-61om170g	346	62	and	and	CC
cord-334133-61om170g	346	63	recycling	recycling	NN
cord-334133-61om170g	346	64	of	of	IN
cord-334133-61om170g	346	65	cell	cell	NN
cord-334133-61om170g	346	66	membrane	membrane	NN
cord-334133-61om170g	346	67	-	-	HYPH
cord-334133-61om170g	346	68	inserted	insert	VBN
cord-334133-61om170g	346	69	gp41	gp41	NN
cord-334133-61om170g	346	70	.	.	.
cord-334133-61om170g	347	1	Because	because	IN
cord-334133-61om170g	347	2	of	of	IN
cord-334133-61om170g	347	3	its	-PRON-	PRP$
cord-334133-61om170g	347	4	location	location	NN
cord-334133-61om170g	347	5	this	this	DT
cord-334133-61om170g	347	6	gp41	gp41	NN
cord-334133-61om170g	347	7	,	,	,
cord-334133-61om170g	347	8	in	in	IN
cord-334133-61om170g	347	9	association	association	NN
cord-334133-61om170g	347	10	with	with	IN
cord-334133-61om170g	347	11	gp120	gp120	NNP
cord-334133-61om170g	347	12	,	,	,
cord-334133-61om170g	347	13	is	be	VBZ
cord-334133-61om170g	347	14	the	the	DT
cord-334133-61om170g	347	15	major	major	JJ
cord-334133-61om170g	347	16	gp41	gp41	NN
cord-334133-61om170g	347	17	form	form	NN
cord-334133-61om170g	347	18	in	in	IN
cord-334133-61om170g	347	19	the	the	DT
cord-334133-61om170g	347	20	cell	cell	NN
cord-334133-61om170g	347	21	membrane	membrane	NN
cord-334133-61om170g	347	22	,	,	,
cord-334133-61om170g	347	23	and	and	CC
cord-334133-61om170g	347	24	the	the	DT
cord-334133-61om170g	347	25	major	major	JJ
cord-334133-61om170g	347	26	gp41form	gp41form	NN
cord-334133-61om170g	347	27	incorporated	incorporate	VBN
cord-334133-61om170g	347	28	into	into	IN
cord-334133-61om170g	347	29	virions	virion	NNS
cord-334133-61om170g	347	30	.	.	.
cord-334133-61om170g	348	1	Co	co	NN
cord-334133-61om170g	348	2	-	-	NN
cord-334133-61om170g	348	3	existence	existence	NN
cord-334133-61om170g	348	4	of	of	IN
cord-334133-61om170g	348	5	two	two	CD
cord-334133-61om170g	348	6	forms	form	NNS
cord-334133-61om170g	348	7	of	of	IN
cord-334133-61om170g	348	8	gp41	gp41	NN
cord-334133-61om170g	348	9	raises	raise	VBZ
cord-334133-61om170g	348	10	questions	question	NNS
cord-334133-61om170g	348	11	,	,	,
cord-334133-61om170g	348	12	which	which	WDT
cord-334133-61om170g	348	13	will	will	MD
cord-334133-61om170g	348	14	require	require	VB
cord-334133-61om170g	348	15	further	further	JJ
cord-334133-61om170g	348	16	work	work	NN
cord-334133-61om170g	348	17	to	to	TO
cord-334133-61om170g	348	18	answer	answer	VB
cord-334133-61om170g	348	19	.	.	.
cord-334133-61om170g	349	1	The	the	DT
cord-334133-61om170g	349	2	mechanism	mechanism	NN
cord-334133-61om170g	349	3	by	by	IN
cord-334133-61om170g	349	4	which	which	WDT
cord-334133-61om170g	349	5	two	two	CD
cord-334133-61om170g	349	6	forms	form	NNS
cord-334133-61om170g	349	7	of	of	IN
cord-334133-61om170g	349	8	gp41	gp41	NNP
cord-334133-61om170g	349	9	arise	arise	NN
cord-334133-61om170g	349	10	is	be	VBZ
cord-334133-61om170g	349	11	not	not	RB
cord-334133-61om170g	349	12	known	know	VBN
cord-334133-61om170g	349	13	,	,	,
cord-334133-61om170g	349	14	although	although	IN
cord-334133-61om170g	349	15	translocational	translocational	NNP
cord-334133-61om170g	349	16	pausing	pause	VBG
cord-334133-61om170g	349	17	may	may	MD
cord-334133-61om170g	349	18	be	be	VB
cord-334133-61om170g	349	19	involved	involve	VBN
cord-334133-61om170g	349	20	in	in	IN
cord-334133-61om170g	349	21	formation	formation	NN
cord-334133-61om170g	349	22	of	of	IN
cord-334133-61om170g	349	23	the	the	DT
cord-334133-61om170g	349	24	multiple	multiple	JJ
cord-334133-61om170g	349	25	MSDs	msds	NN
cord-334133-61om170g	349	26	(	(	-LRB-
cord-334133-61om170g	349	27	Dettenhofer	Dettenhofer	NNP
cord-334133-61om170g	349	28	and	and	CC
cord-334133-61om170g	349	29	Yu	Yu	NNP
cord-334133-61om170g	349	30	,	,	,
cord-334133-61om170g	349	31	2001	2001	CD
cord-334133-61om170g	349	32	)	)	-RRB-
cord-334133-61om170g	349	33	.	.	.
cord-334133-61om170g	350	1	The	the	DT
cord-334133-61om170g	350	2	1-and	1-and	CD
cord-334133-61om170g	350	3	3-MSD	3-msd	CD
cord-334133-61om170g	350	4	forms	form	NNS
cord-334133-61om170g	350	5	are	be	VBP
cord-334133-61om170g	350	6	proposed	propose	VBN
cord-334133-61om170g	350	7	to	to	TO
cord-334133-61om170g	350	8	be	be	VB
cord-334133-61om170g	350	9	a	a	DT
cord-334133-61om170g	350	10	-	-	HYPH
cord-334133-61om170g	350	11	helix	helix	NN
cord-334133-61om170g	350	12	and	and	CC
cord-334133-61om170g	350	13	h	h	NN
cord-334133-61om170g	350	14	-	-	HYPH
cord-334133-61om170g	350	15	sheet	sheet	NN
cord-334133-61om170g	350	16	,	,	,
cord-334133-61om170g	350	17	respectively	respectively	RB
cord-334133-61om170g	350	18	,	,	,
cord-334133-61om170g	350	19	and	and	CC
cord-334133-61om170g	350	20	it	-PRON-	PRP
cord-334133-61om170g	350	21	is	be	VBZ
cord-334133-61om170g	350	22	noted	note	VBN
cord-334133-61om170g	350	23	above	above	IN
cord-334133-61om170g	350	24	that	that	DT
cord-334133-61om170g	350	25	structure	structure	NN
cord-334133-61om170g	350	26	predications	predication	NNS
cord-334133-61om170g	350	27	allow	allow	VBP
cord-334133-61om170g	350	28	for	for	IN
cord-334133-61om170g	350	29	either	either	DT
cord-334133-61om170g	350	30	conformation	conformation	NN
cord-334133-61om170g	350	31	.	.	.
cord-334133-61om170g	351	1	Conformation	conformation	NN
cord-334133-61om170g	351	2	may	may	MD
cord-334133-61om170g	351	3	be	be	VB
cord-334133-61om170g	351	4	determined	determine	VBN
cord-334133-61om170g	351	5	by	by	IN
cord-334133-61om170g	351	6	the	the	DT
cord-334133-61om170g	351	7	length	length	NN
cord-334133-61om170g	351	8	of	of	IN
cord-334133-61om170g	351	9	unbroken	unbroken	JJ
cord-334133-61om170g	351	10	MSD	MSD	NNP
cord-334133-61om170g	351	11	sequence	sequence	NN
cord-334133-61om170g	351	12	,	,	,
cord-334133-61om170g	351	13	as	as	IN
cord-334133-61om170g	351	14	a	a	DT
cord-334133-61om170g	351	15	long	long	JJ
cord-334133-61om170g	351	16	sequence	sequence	NN
cord-334133-61om170g	351	17	of	of	IN
cord-334133-61om170g	351	18	lower	low	JJR
cord-334133-61om170g	351	19	value	value	NN
cord-334133-61om170g	351	20	a	a	DT
cord-334133-61om170g	351	21	-	-	HYPH
cord-334133-61om170g	351	22	helix	helix	NN
cord-334133-61om170g	351	23	,	,	,
cord-334133-61om170g	351	24	can	can	MD
cord-334133-61om170g	351	25	take	take	VB
cord-334133-61om170g	351	26	precedence	precedence	NN
cord-334133-61om170g	351	27	over	over	IN
cord-334133-61om170g	351	28	a	a	DT
cord-334133-61om170g	351	29	higher	high	JJR
cord-334133-61om170g	351	30	value	value	NN
cord-334133-61om170g	351	31	,	,	,
cord-334133-61om170g	351	32	shorter	short	JJR
cord-334133-61om170g	351	33	h	h	NN
cord-334133-61om170g	351	34	-	-	HYPH
cord-334133-61om170g	351	35	sheet	sheet	NN
cord-334133-61om170g	351	36	region	region	NN
cord-334133-61om170g	351	37	(	(	-LRB-
cord-334133-61om170g	351	38	Chou	Chou	NNP
cord-334133-61om170g	351	39	and	and	CC
cord-334133-61om170g	351	40	Fasman	Fasman	NNP
cord-334133-61om170g	351	41	,	,	,
cord-334133-61om170g	351	42	1978	1978	CD
cord-334133-61om170g	351	43	)	)	-RRB-
cord-334133-61om170g	351	44	.	.	.
cord-334133-61om170g	352	1	The	the	DT
cord-334133-61om170g	352	2	conventional	conventional	JJ
cord-334133-61om170g	352	3	1-MSD	1-msd	CD
cord-334133-61om170g	352	4	model	model	NN
cord-334133-61om170g	352	5	still	still	RB
cord-334133-61om170g	352	6	has	have	VBZ
cord-334133-61om170g	352	7	the	the	DT
cord-334133-61om170g	352	8	problem	problem	NN
cord-334133-61om170g	352	9	of	of	IN
cord-334133-61om170g	352	10	703	703	CD
cord-334133-61om170g	352	11	R	r	NN
cord-334133-61om170g	352	12	being	be	VBG
cord-334133-61om170g	352	13	centrally	centrally	RB
cord-334133-61om170g	352	14	located	locate	VBN
cord-334133-61om170g	352	15	in	in	IN
cord-334133-61om170g	352	16	the	the	DT
cord-334133-61om170g	352	17	membrane	membrane	NN
cord-334133-61om170g	352	18	with	with	IN
cord-334133-61om170g	352	19	no	no	DT
cord-334133-61om170g	352	20	counter	counter	JJ
cord-334133-61om170g	352	21	charge	charge	NN
cord-334133-61om170g	352	22	.	.	.
cord-334133-61om170g	353	1	However	however	RB
cord-334133-61om170g	353	2	,	,	,
cord-334133-61om170g	353	3	a	a	DT
cord-334133-61om170g	353	4	recent	recent	JJ
cord-334133-61om170g	353	5	suggestion	suggestion	NN
cord-334133-61om170g	353	6	that	that	IN
cord-334133-61om170g	353	7	the	the	DT
cord-334133-61om170g	353	8	703	703	CD
cord-334133-61om170g	353	9	R	r	NN
cord-334133-61om170g	353	10	equivalent	equivalent	NN
cord-334133-61om170g	353	11	in	in	IN
cord-334133-61om170g	353	12	SIV	SIV	NNP
cord-334133-61om170g	353	13	is	be	VBZ
cord-334133-61om170g	353	14	situated	situate	VBN
cord-334133-61om170g	353	15	in	in	IN
cord-334133-61om170g	353	16	a	a	DT
cord-334133-61om170g	353	17	position	position	NN
cord-334133-61om170g	353	18	where	where	WRB
cord-334133-61om170g	353	19	it	-PRON-	PRP
cord-334133-61om170g	353	20	can	can	MD
cord-334133-61om170g	353	21	react	react	VB
cord-334133-61om170g	353	22	with	with	IN
cord-334133-61om170g	353	23	the	the	DT
cord-334133-61om170g	353	24	polar	polar	JJ
cord-334133-61om170g	353	25	lipid	lipid	NN
cord-334133-61om170g	353	26	head	head	NN
cord-334133-61om170g	353	27	groups	group	NNS
cord-334133-61om170g	353	28	may	may	MD
cord-334133-61om170g	353	29	provide	provide	VB
cord-334133-61om170g	353	30	a	a	DT
cord-334133-61om170g	353	31	solution	solution	NN
cord-334133-61om170g	353	32	(	(	-LRB-
cord-334133-61om170g	353	33	West	West	NNP
cord-334133-61om170g	353	34	et	et	NNP
cord-334133-61om170g	353	35	al	al	NNP
cord-334133-61om170g	353	36	.	.	NNP
cord-334133-61om170g	353	37	,	,	,
cord-334133-61om170g	353	38	2001	2001	CD
cord-334133-61om170g	353	39	)	)	-RRB-
cord-334133-61om170g	353	40	.	.	.
cord-334133-61om170g	354	1	Degradation	degradation	NN
cord-334133-61om170g	354	2	of	of	IN
cord-334133-61om170g	354	3	the	the	DT
cord-334133-61om170g	354	4	1-MSD	1-msd	CD
cord-334133-61om170g	354	5	gp41	gp41	NN
cord-334133-61om170g	354	6	and	and	CC
cord-334133-61om170g	354	7	recycling	recycling	NN
cord-334133-61om170g	354	8	of	of	IN
cord-334133-61om170g	354	9	the	the	DT
cord-334133-61om170g	354	10	3-MSD	3-msd	CD
cord-334133-61om170g	354	11	form	form	NN
cord-334133-61om170g	354	12	would	would	MD
cord-334133-61om170g	354	13	both	both	DT
cord-334133-61om170g	354	14	act	act	VB
cord-334133-61om170g	354	15	to	to	TO
cord-334133-61om170g	354	16	reduce	reduce	VB
cord-334133-61om170g	354	17	the	the	DT
cord-334133-61om170g	354	18	surface	surface	NN
cord-334133-61om170g	354	19	expression	expression	NN
cord-334133-61om170g	354	20	of	of	IN
cord-334133-61om170g	354	21	gp120-gp41	gp120-gp41	NNP
cord-334133-61om170g	354	22	.	.	.
cord-334133-61om170g	355	1	This	this	DT
cord-334133-61om170g	355	2	may	may	MD
cord-334133-61om170g	355	3	be	be	VB
cord-334133-61om170g	355	4	important	important	JJ
cord-334133-61om170g	355	5	,	,	,
cord-334133-61om170g	355	6	as	as	IN
cord-334133-61om170g	355	7	high	high	JJ
cord-334133-61om170g	355	8	intracellular	intracellular	JJ
cord-334133-61om170g	355	9	concentrations	concentration	NNS
cord-334133-61om170g	355	10	of	of	IN
cord-334133-61om170g	355	11	gp41	gp41	NNP
cord-334133-61om170g	355	12	can	can	MD
cord-334133-61om170g	355	13	be	be	VB
cord-334133-61om170g	355	14	cytotoxic	cytotoxic	JJ
cord-334133-61om170g	356	1	(	(	-LRB-
cord-334133-61om170g	356	2	Arroyo	Arroyo	NNP
cord-334133-61om170g	356	3	et	et	NNP
cord-334133-61om170g	356	4	al	al	NNP
cord-334133-61om170g	356	5	.	.	NNP
cord-334133-61om170g	356	6	,	,	,
cord-334133-61om170g	356	7	1995	1995	CD
cord-334133-61om170g	356	8	;	;	:
cord-334133-61om170g	356	9	Chernomordik	Chernomordik	NNP
cord-334133-61om170g	356	10	et	et	FW
cord-334133-61om170g	356	11	al	al	NNP
cord-334133-61om170g	356	12	.	.	.
cord-334133-61om170g	357	1	,	,	,
cord-334133-61om170g	357	2	1994	1994	CD
cord-334133-61om170g	357	3	;	;	:
cord-334133-61om170g	357	4	Comardelle	Comardelle	NNP
cord-334133-61om170g	357	5	et	et	NNP
cord-334133-61om170g	357	6	al	al	NNP
cord-334133-61om170g	357	7	.	.	NNP
cord-334133-61om170g	357	8	,	,	,
cord-334133-61om170g	357	9	1997	1997	CD
cord-334133-61om170g	358	1	;	;	:
cord-334133-61om170g	358	2	Gawrisch	Gawrisch	NNP
cord-334133-61om170g	358	3	et	et	NNP
cord-334133-61om170g	358	4	al	al	NNP
cord-334133-61om170g	358	5	.	.	NNP
cord-334133-61om170g	358	6	,	,	,
cord-334133-61om170g	358	7	1993	1993	CD
cord-334133-61om170g	358	8	;	;	:
cord-334133-61om170g	358	9	Miller	Miller	NNP
cord-334133-61om170g	358	10	et	et	NNP
cord-334133-61om170g	358	11	al	al	NNP
cord-334133-61om170g	358	12	.	.	NNP
cord-334133-61om170g	358	13	,	,	,
cord-334133-61om170g	358	14	1993	1993	CD
cord-334133-61om170g	359	1	;	;	:
cord-334133-61om170g	359	2	Zhang	Zhang	NNP
cord-334133-61om170g	359	3	et	et	NNP
cord-334133-61om170g	359	4	al	al	NNP
cord-334133-61om170g	359	5	.	.	NNP
cord-334133-61om170g	359	6	,	,	,
cord-334133-61om170g	359	7	1996	1996	CD
cord-334133-61om170g	359	8	)	)	-RRB-
cord-334133-61om170g	359	9	,	,	,
cord-334133-61om170g	359	10	and	and	CC
cord-334133-61om170g	359	11	provoke	provoke	VB
cord-334133-61om170g	359	12	immune	immune	JJ
cord-334133-61om170g	359	13	responses	response	NNS
cord-334133-61om170g	359	14	against	against	IN
cord-334133-61om170g	359	15	the	the	DT
cord-334133-61om170g	359	16	infected	infected	JJ
cord-334133-61om170g	359	17	cell	cell	NN
cord-334133-61om170g	359	18	.	.	.
cord-334133-61om170g	360	1	It	-PRON-	PRP
cord-334133-61om170g	360	2	may	may	MD
cord-334133-61om170g	360	3	be	be	VB
cord-334133-61om170g	360	4	that	that	IN
cord-334133-61om170g	360	5	such	such	JJ
cord-334133-61om170g	360	6	post	post	JJ
cord-334133-61om170g	360	7	-	-	JJ
cord-334133-61om170g	360	8	translational	translational	JJ
cord-334133-61om170g	360	9	control	control	NN
cord-334133-61om170g	360	10	measures	measure	NNS
cord-334133-61om170g	360	11	,	,	,
cord-334133-61om170g	360	12	utilizing	utilize	VBG
cord-334133-61om170g	360	13	tyrosine	tyrosine	NN
cord-334133-61om170g	360	14	-	-	HYPH
cord-334133-61om170g	360	15	dependent	dependent	JJ
cord-334133-61om170g	360	16	sorting	sorting	NN
cord-334133-61om170g	360	17	signals	signal	NNS
cord-334133-61om170g	360	18	and	and	CC
cord-334133-61om170g	360	19	the	the	DT
cord-334133-61om170g	360	20	host	host	NN
cord-334133-61om170g	360	21	cell	cell	NN
cord-334133-61om170g	360	22	's	's	POS
cord-334133-61om170g	360	23	degradation	degradation	NN
cord-334133-61om170g	360	24	pathways	pathway	NNS
cord-334133-61om170g	360	25	,	,	,
cord-334133-61om170g	360	26	have	have	VBP
cord-334133-61om170g	360	27	evolved	evolve	VBN
cord-334133-61om170g	360	28	as	as	IN
cord-334133-61om170g	360	29	envelope	envelope	NN
cord-334133-61om170g	360	30	expression	expression	NN
cord-334133-61om170g	360	31	is	be	VBZ
cord-334133-61om170g	360	32	not	not	RB
cord-334133-61om170g	360	33	easily	easily	RB
cord-334133-61om170g	360	34	controlled	control	VBN
cord-334133-61om170g	360	35	at	at	IN
cord-334133-61om170g	360	36	a	a	DT
cord-334133-61om170g	360	37	genetic	genetic	JJ
cord-334133-61om170g	360	38	level	level	NN
cord-334133-61om170g	360	39	due	due	IN
cord-334133-61om170g	360	40	to	to	IN
cord-334133-61om170g	360	41	the	the	DT
cord-334133-61om170g	360	42	overlap	overlap	NN
cord-334133-61om170g	360	43	of	of	IN
cord-334133-61om170g	360	44	the	the	DT
cord-334133-61om170g	360	45	env	env	NN
cord-334133-61om170g	360	46	,	,	,
cord-334133-61om170g	360	47	tat	tat	NNP
cord-334133-61om170g	360	48	,	,	,
cord-334133-61om170g	360	49	and	and	CC
cord-334133-61om170g	360	50	rev	rev	NNP
cord-334133-61om170g	360	51	ORFs	ORFs	NNP
cord-334133-61om170g	360	52	.	.	.
cord-334133-61om170g	361	1	The	the	DT
cord-334133-61om170g	361	2	suggestion	suggestion	NN
cord-334133-61om170g	361	3	above	above	IN
cord-334133-61om170g	361	4	that	that	IN
cord-334133-61om170g	361	5	a	a	DT
cord-334133-61om170g	361	6	membrane	membrane	NN
cord-334133-61om170g	361	7	-	-	HYPH
cord-334133-61om170g	361	8	inserted	insert	VBN
cord-334133-61om170g	361	9	viral	viral	JJ
cord-334133-61om170g	361	10	protein	protein	NN
cord-334133-61om170g	361	11	can	can	MD
cord-334133-61om170g	361	12	have	have	VB
cord-334133-61om170g	361	13	different	different	JJ
cord-334133-61om170g	361	14	numbers	number	NNS
cord-334133-61om170g	361	15	of	of	IN
cord-334133-61om170g	361	16	MSDs	msds	NN
cord-334133-61om170g	361	17	is	be	VBZ
cord-334133-61om170g	361	18	not	not	RB
cord-334133-61om170g	361	19	unique	unique	JJ
cord-334133-61om170g	361	20	.	.	.
cord-334133-61om170g	362	1	For	for	IN
cord-334133-61om170g	362	2	example	example	NN
cord-334133-61om170g	362	3	,	,	,
cord-334133-61om170g	362	4	the	the	DT
cord-334133-61om170g	362	5	GL	GL	NNP
cord-334133-61om170g	362	6	envelope	envelope	NN
cord-334133-61om170g	362	7	protein	protein	NN
cord-334133-61om170g	362	8	of	of	IN
cord-334133-61om170g	362	9	equine	equine	JJ
cord-334133-61om170g	362	10	arteritis	arteritis	NN
cord-334133-61om170g	362	11	virus	virus	NN
cord-334133-61om170g	362	12	is	be	VBZ
cord-334133-61om170g	362	13	proposed	propose	VBN
cord-334133-61om170g	362	14	to	to	TO
cord-334133-61om170g	362	15	have	have	VB
cord-334133-61om170g	362	16	1	1	CD
cord-334133-61om170g	362	17	or	or	CC
cord-334133-61om170g	362	18	3	3	CD
cord-334133-61om170g	362	19	MSDs	msds	NN
cord-334133-61om170g	362	20	(	(	-LRB-
cord-334133-61om170g	362	21	Snijder	Snijder	NNP
cord-334133-61om170g	362	22	and	and	CC
cord-334133-61om170g	362	23	Meulenberg	Meulenberg	NNP
cord-334133-61om170g	362	24	,	,	,
cord-334133-61om170g	362	25	1998	1998	CD
cord-334133-61om170g	362	26	)	)	-RRB-
cord-334133-61om170g	362	27	,	,	,
cord-334133-61om170g	362	28	the	the	DT
cord-334133-61om170g	362	29	M	M	NNP
cord-334133-61om170g	362	30	protein	protein	NN
cord-334133-61om170g	362	31	of	of	IN
cord-334133-61om170g	362	32	transmissible	transmissible	JJ
cord-334133-61om170g	362	33	gastroenteritis	gastroenteritis	JJ
cord-334133-61om170g	362	34	coronavirus	coronavirus	NN
cord-334133-61om170g	362	35	and	and	CC
cord-334133-61om170g	362	36	equine	equine	JJ
cord-334133-61om170g	362	37	arteritis	arteritis	NN
cord-334133-61om170g	362	38	virus	virus	NN
cord-334133-61om170g	362	39	,	,	,
cord-334133-61om170g	362	40	and	and	CC
cord-334133-61om170g	362	41	the	the	DT
cord-334133-61om170g	362	42	S	S	NNP
cord-334133-61om170g	362	43	antigen	antigen	NN
cord-334133-61om170g	362	44	of	of	IN
cord-334133-61om170g	362	45	hepatitis	hepatitis	NN
cord-334133-61om170g	362	46	B	B	NNP
cord-334133-61om170g	362	47	virus	virus	NN
cord-334133-61om170g	362	48	are	be	VBP
cord-334133-61om170g	362	49	proposed	propose	VBN
cord-334133-61om170g	362	50	to	to	TO
cord-334133-61om170g	362	51	have	have	VB
cord-334133-61om170g	362	52	three	three	CD
cord-334133-61om170g	362	53	or	or	CC
cord-334133-61om170g	362	54	four	four	CD
cord-334133-61om170g	362	55	MSDs	msd	NNS
cord-334133-61om170g	362	56	(	(	-LRB-
cord-334133-61om170g	362	57	Prange	Prange	NNP
cord-334133-61om170g	362	58	and	and	CC
cord-334133-61om170g	362	59	Streeck	Streeck	NNP
cord-334133-61om170g	362	60	,	,	,
cord-334133-61om170g	362	61	1995	1995	CD
cord-334133-61om170g	362	62	;	;	:
cord-334133-61om170g	362	63	Risco	Risco	NNP
cord-334133-61om170g	362	64	et	et	NNP
cord-334133-61om170g	362	65	al	al	NNP
cord-334133-61om170g	362	66	.	.	NNP
cord-334133-61om170g	362	67	,	,	,
cord-334133-61om170g	362	68	1995	1995	CD
cord-334133-61om170g	362	69	;	;	:
cord-334133-61om170g	362	70	Snijder	Snijder	NNP
cord-334133-61om170g	362	71	and	and	CC
cord-334133-61om170g	362	72	Meulenberg	Meulenberg	NNP
cord-334133-61om170g	362	73	,	,	,
cord-334133-61om170g	362	74	1998	1998	CD
cord-334133-61om170g	362	75	)	)	-RRB-
cord-334133-61om170g	362	76	,	,	,
cord-334133-61om170g	362	77	and	and	CC
cord-334133-61om170g	362	78	the	the	DT
cord-334133-61om170g	362	79	herpes	herpes	NNP
cord-334133-61om170g	362	80	simplex	simplex	NNP
cord-334133-61om170g	362	81	virus	virus	NN
cord-334133-61om170g	362	82	glycoprotein	glycoprotein	NN
cord-334133-61om170g	362	83	B	b	NN
cord-334133-61om170g	362	84	(	(	-LRB-
cord-334133-61om170g	362	85	Pellett	Pellett	NNP
cord-334133-61om170g	362	86	et	et	FW
cord-334133-61om170g	362	87	al	al	NNP
cord-334133-61om170g	362	88	.	.	NNP
cord-334133-61om170g	362	89	,	,	,
cord-334133-61om170g	362	90	1985	1985	CD
cord-334133-61om170g	362	91	)	)	-RRB-
cord-334133-61om170g	362	92	,	,	,
cord-334133-61om170g	362	93	and	and	CC
cord-334133-61om170g	362	94	the	the	DT
cord-334133-61om170g	362	95	Epstein	Epstein	NNP
cord-334133-61om170g	362	96	-Barr	-Barr	NNP
cord-334133-61om170g	362	97	virus	virus	NN
cord-334133-61om170g	362	98	58	58	CD
cord-334133-61om170g	362	99	kDa	kDa	NNS
cord-334133-61om170g	362	100	latent	latent	NN
cord-334133-61om170g	362	101	protein	protein	NN
cord-334133-61om170g	362	102	Hennessy	Hennessy	NNP
cord-334133-61om170g	362	103	et	et	NNP
cord-334133-61om170g	362	104	al	al	NNP
cord-334133-61om170g	362	105	.	.	NNP
cord-334133-61om170g	362	106	,	,	,
cord-334133-61om170g	362	107	1984	1984	CD
cord-334133-61om170g	362	108	)	)	-RRB-
cord-334133-61om170g	362	109	both	both	DT
cord-334133-61om170g	362	110	have	have	VBP
cord-334133-61om170g	362	111	multiple	multiple	JJ
cord-334133-61om170g	362	112	MSDs	msd	NNS
cord-334133-61om170g	362	113	.	.	.
cord-334133-61om170g	363	1	Based	base	VBN
cord-334133-61om170g	363	2	on	on	IN
cord-334133-61om170g	363	3	an	an	DT
cord-334133-61om170g	363	4	analysis	analysis	NN
cord-334133-61om170g	363	5	of	of	IN
cord-334133-61om170g	363	6	their	-PRON-	PRP$
cord-334133-61om170g	363	7	sequence	sequence	NN
cord-334133-61om170g	363	8	and	and	CC
cord-334133-61om170g	363	9	structure	structure	NN
cord-334133-61om170g	363	10	,	,	,
cord-334133-61om170g	363	11	we	-PRON-	PRP
cord-334133-61om170g	363	12	propose	propose	VBP
cord-334133-61om170g	363	13	that	that	IN
cord-334133-61om170g	363	14	the	the	DT
cord-334133-61om170g	363	15	gp41	gp41	NNP
cord-334133-61om170g	363	16	transmembrane	transmembrane	NN
cord-334133-61om170g	363	17	region	region	NN
cord-334133-61om170g	363	18	and	and	CC
cord-334133-61om170g	363	19	C	c	NN
cord-334133-61om170g	363	20	-	-	HYPH
cord-334133-61om170g	363	21	terminal	terminal	NN
cord-334133-61om170g	363	22	tail	tail	NN
cord-334133-61om170g	363	23	of	of	IN
cord-334133-61om170g	363	24	all	all	DT
cord-334133-61om170g	363	25	HIV-1	HIV-1	NNP
cord-334133-61om170g	363	26	clades	clade	NNS
cord-334133-61om170g	364	1	A	a	NN
cord-334133-61om170g	364	2	to	to	IN
cord-334133-61om170g	364	3	D	d	NN
cord-334133-61om170g	364	4	can	can	MD
cord-334133-61om170g	364	5	exist	exist	VB
cord-334133-61om170g	364	6	in	in	IN
cord-334133-61om170g	364	7	two	two	CD
cord-334133-61om170g	364	8	conformations	conformation	NNS
cord-334133-61om170g	364	9	,	,	,
cord-334133-61om170g	364	10	with	with	IN
cord-334133-61om170g	364	11	either	either	DT
cord-334133-61om170g	364	12	1	1	CD
cord-334133-61om170g	364	13	MSD	MSD	NNP
cord-334133-61om170g	364	14	(	(	-LRB-
cord-334133-61om170g	364	15	the	the	DT
cord-334133-61om170g	364	16	conventional	conventional	JJ
cord-334133-61om170g	364	17	structure	structure	NN
cord-334133-61om170g	364	18	)	)	-RRB-
cord-334133-61om170g	364	19	or	or	CC
cord-334133-61om170g	364	20	with	with	IN
cord-334133-61om170g	364	21	3	3	CD
cord-334133-61om170g	364	22	MSDs	msd	NNS
cord-334133-61om170g	364	23	.	.	.
cord-334133-61om170g	365	1	We	-PRON-	PRP
cord-334133-61om170g	365	2	suggest	suggest	VBP
cord-334133-61om170g	365	3	that	that	IN
cord-334133-61om170g	365	4	these	these	DT
cord-334133-61om170g	365	5	are	be	VBP
cord-334133-61om170g	365	6	,	,	,
cord-334133-61om170g	365	7	respectively	respectively	RB
cord-334133-61om170g	365	8	,	,	,
cord-334133-61om170g	365	9	the	the	DT
cord-334133-61om170g	365	10	majority	majority	NN
cord-334133-61om170g	365	11	and	and	CC
cord-334133-61om170g	365	12	minority	minority	NN
cord-334133-61om170g	365	13	forms	form	NNS
cord-334133-61om170g	365	14	of	of	IN
cord-334133-61om170g	365	15	intracellular	intracellular	JJ
cord-334133-61om170g	365	16	Env	Env	NNP
cord-334133-61om170g	365	17	.	.	.
cord-334133-61om170g	366	1	In	in	IN
cord-334133-61om170g	366	2	the	the	DT
cord-334133-61om170g	366	3	3-MSD	3-msd	CD
cord-334133-61om170g	366	4	form	form	NN
cord-334133-61om170g	366	5	,	,	,
cord-334133-61om170g	366	6	MSD	MSD	NNP
cord-334133-61om170g	366	7	1	1	CD
cord-334133-61om170g	366	8	and	and	CC
cord-334133-61om170g	366	9	MSD	MSD	NNP
cord-334133-61om170g	366	10	2	2	CD
cord-334133-61om170g	366	11	are	be	VBP
cord-334133-61om170g	366	12	separated	separate	VBN
cord-334133-61om170g	366	13	by	by	IN
cord-334133-61om170g	366	14	a	a	DT
cord-334133-61om170g	366	15	highly	highly	RB
cord-334133-61om170g	366	16	conserved	conserve	VBN
cord-334133-61om170g	366	17	beta	beta	NN
cord-334133-61om170g	366	18	turn	turn	NN
cord-334133-61om170g	366	19	,	,	,
cord-334133-61om170g	366	20	while	while	IN
cord-334133-61om170g	366	21	the	the	DT
cord-334133-61om170g	366	22	MSD	MSD	NNP
cord-334133-61om170g	366	23	2	2	CD
cord-334133-61om170g	366	24	and	and	CC
cord-334133-61om170g	366	25	MSD	MSD	NNP
cord-334133-61om170g	366	26	3	3	CD
cord-334133-61om170g	366	27	support	support	VBP
cord-334133-61om170g	366	28	an	an	DT
cord-334133-61om170g	366	29	unstructured	unstructured	JJ
cord-334133-61om170g	366	30	hydrophilic	hydrophilic	JJ
cord-334133-61om170g	366	31	loop	loop	NN
cord-334133-61om170g	366	32	/	/	SYM
cord-334133-61om170g	366	33	minor	minor	JJ
cord-334133-61om170g	366	34	ectodomain	ectodomain	NN
cord-334133-61om170g	366	35	of	of	IN
cord-334133-61om170g	366	36	41	41	CD
cord-334133-61om170g	366	37	residues	residue	NNS
cord-334133-61om170g	366	38	that	that	WDT
cord-334133-61om170g	366	39	in	in	IN
cord-334133-61om170g	366	40	clade	clade	NN
cord-334133-61om170g	366	41	B	b	NN
cord-334133-61om170g	366	42	strains	strain	NNS
cord-334133-61om170g	366	43	is	be	VBZ
cord-334133-61om170g	366	44	highly	highly	RB
cord-334133-61om170g	366	45	antibody	antibody	NN
cord-334133-61om170g	366	46	-	-	HYPH
cord-334133-61om170g	366	47	reactive	reactive	JJ
cord-334133-61om170g	366	48	and	and	CC
cord-334133-61om170g	366	49	involved	involve	VBN
cord-334133-61om170g	366	50	in	in	IN
cord-334133-61om170g	366	51	fusion	fusion	NN
cord-334133-61om170g	366	52	.	.	.
cord-334133-61om170g	367	1	All	all	DT
cord-334133-61om170g	367	2	viruses	virus	NNS
cord-334133-61om170g	367	3	have	have	VBP
cord-334133-61om170g	367	4	two	two	CD
cord-334133-61om170g	367	5	potential	potential	JJ
cord-334133-61om170g	367	6	tyrosine	tyrosine	NN
cord-334133-61om170g	367	7	-	-	HYPH
cord-334133-61om170g	367	8	dependent	dependent	JJ
cord-334133-61om170g	367	9	sorting	sorting	NN
cord-334133-61om170g	367	10	signals	signal	NNS
cord-334133-61om170g	367	11	within	within	IN
cord-334133-61om170g	367	12	the	the	DT
cord-334133-61om170g	367	13	region	region	NN
cord-334133-61om170g	367	14	analyzed	analyze	VBD
cord-334133-61om170g	367	15	.	.	.
cord-334133-61om170g	368	1	In	in	IN
cord-334133-61om170g	368	2	the	the	DT
cord-334133-61om170g	368	3	1-MSD	1-msd	CD
cord-334133-61om170g	368	4	model	model	NN
cord-334133-61om170g	368	5	it	-PRON-	PRP
cord-334133-61om170g	368	6	is	be	VBZ
cord-334133-61om170g	368	7	likely	likely	JJ
cord-334133-61om170g	368	8	that	that	IN
cord-334133-61om170g	368	9	only	only	RB
cord-334133-61om170g	368	10	the	the	DT
cord-334133-61om170g	368	11	N	n	CD
cord-334133-61om170g	368	12	-	-	HYPH
cord-334133-61om170g	368	13	terminal	terminal	NN
cord-334133-61om170g	368	14	signal	signal	NN
cord-334133-61om170g	368	15	is	be	VBZ
cord-334133-61om170g	368	16	functional	functional	JJ
cord-334133-61om170g	368	17	,	,	,
cord-334133-61om170g	368	18	and	and	CC
cord-334133-61om170g	368	19	that	that	IN
cord-334133-61om170g	368	20	this	this	DT
cord-334133-61om170g	368	21	interacts	interact	VBZ
cord-334133-61om170g	368	22	with	with	IN
cord-334133-61om170g	368	23	AP-1	AP-1	NNP
cord-334133-61om170g	368	24	and	and	CC
cord-334133-61om170g	368	25	AP-3	AP-3	NNP
cord-334133-61om170g	368	26	to	to	TO
cord-334133-61om170g	368	27	direct	direct	VB
cord-334133-61om170g	368	28	Env	Env	NNP
cord-334133-61om170g	368	29	from	from	IN
cord-334133-61om170g	368	30	the	the	DT
cord-334133-61om170g	368	31	TGN	TGN	NNP
cord-334133-61om170g	368	32	to	to	TO
cord-334133-61om170g	368	33	degradation	degradation	NN
cord-334133-61om170g	368	34	in	in	IN
cord-334133-61om170g	368	35	the	the	DT
cord-334133-61om170g	368	36	lysosomes	lysosome	NNS
cord-334133-61om170g	368	37	.	.	.
cord-334133-61om170g	369	1	In	in	IN
cord-334133-61om170g	369	2	the	the	DT
cord-334133-61om170g	369	3	3-MSD	3-msd	CD
cord-334133-61om170g	369	4	version	version	NN
cord-334133-61om170g	369	5	,	,	,
cord-334133-61om170g	369	6	the	the	DT
cord-334133-61om170g	369	7	Nterminal	Nterminal	NNP
cord-334133-61om170g	369	8	signal	signal	NN
cord-334133-61om170g	369	9	is	be	VBZ
cord-334133-61om170g	369	10	situated	situate	VBN
cord-334133-61om170g	369	11	outside	outside	IN
cord-334133-61om170g	369	12	the	the	DT
cord-334133-61om170g	369	13	membrane	membrane	NN
cord-334133-61om170g	369	14	and	and	CC
cord-334133-61om170g	369	15	nonfunctional	nonfunctional	JJ
cord-334133-61om170g	369	16	,	,	,
cord-334133-61om170g	369	17	thus	thus	RB
cord-334133-61om170g	369	18	allowing	allow	VBG
cord-334133-61om170g	369	19	this	this	DT
cord-334133-61om170g	369	20	form	form	NN
cord-334133-61om170g	369	21	of	of	IN
cord-334133-61om170g	369	22	gp41	gp41	NNP
cord-334133-61om170g	369	23	to	to	TO
cord-334133-61om170g	369	24	reach	reach	VB
cord-334133-61om170g	369	25	the	the	DT
cord-334133-61om170g	369	26	cell	cell	NN
cord-334133-61om170g	369	27	membrane	membrane	NN
cord-334133-61om170g	369	28	.	.	.
cord-334133-61om170g	370	1	Thus	thus	RB
cord-334133-61om170g	370	2	,	,	,
cord-334133-61om170g	370	3	it	-PRON-	PRP
cord-334133-61om170g	370	4	seems	seem	VBZ
cord-334133-61om170g	370	5	that	that	IN
cord-334133-61om170g	370	6	the	the	DT
cord-334133-61om170g	370	7	3-MSD	3-msd	CD
cord-334133-61om170g	370	8	form	form	NN
cord-334133-61om170g	370	9	is	be	VBZ
cord-334133-61om170g	370	10	the	the	DT
cord-334133-61om170g	370	11	majority	majority	NN
cord-334133-61om170g	370	12	species	specie	NNS
cord-334133-61om170g	370	13	on	on	IN
cord-334133-61om170g	370	14	the	the	DT
cord-334133-61om170g	370	15	cell	cell	NN
cord-334133-61om170g	370	16	surface	surface	NN
cord-334133-61om170g	370	17	and	and	CC
cord-334133-61om170g	370	18	hence	hence	RB
cord-334133-61om170g	370	19	in	in	IN
cord-334133-61om170g	370	20	virions	virion	NNS
cord-334133-61om170g	370	21	.	.	.
cord-334133-61om170g	371	1	We	-PRON-	PRP
cord-334133-61om170g	371	2	propose	propose	VBP
cord-334133-61om170g	371	3	that	that	IN
cord-334133-61om170g	371	4	the	the	DT
cord-334133-61om170g	371	5	second	second	JJ
cord-334133-61om170g	371	6	signal	signal	NN
cord-334133-61om170g	371	7	is	be	VBZ
cord-334133-61om170g	371	8	functional	functional	JJ
cord-334133-61om170g	371	9	in	in	IN
cord-334133-61om170g	371	10	the	the	DT
cord-334133-61om170g	371	11	3-MSD	3-msd	CD
cord-334133-61om170g	371	12	gp41	gp41	NN
cord-334133-61om170g	371	13	,	,	,
cord-334133-61om170g	371	14	and	and	CC
cord-334133-61om170g	371	15	controls	control	VBZ
cord-334133-61om170g	371	16	recycling	recycling	NN
cord-334133-61om170g	371	17	of	of	IN
cord-334133-61om170g	371	18	cell	cell	NN
cord-334133-61om170g	371	19	surface	surface	NN
cord-334133-61om170g	371	20	Env	Env	NNP
cord-334133-61om170g	371	21	.	.	.
cord-334133-61om170g	372	1	The	the	DT
cord-334133-61om170g	372	2	1-and	1-and	CD
cord-334133-61om170g	372	3	3-MSD	3-msd	CD
cord-334133-61om170g	372	4	strategy	strategy	NN
cord-334133-61om170g	372	5	can	can	MD
cord-334133-61om170g	372	6	be	be	VB
cord-334133-61om170g	372	7	seen	see	VBN
cord-334133-61om170g	372	8	as	as	IN
cord-334133-61om170g	372	9	an	an	DT
cord-334133-61om170g	372	10	evolutionary	evolutionary	JJ
cord-334133-61om170g	372	11	adaptation	adaptation	NN
cord-334133-61om170g	372	12	that	that	WDT
cord-334133-61om170g	372	13	allows	allow	VBZ
cord-334133-61om170g	372	14	HIV-1-infected	hiv-1-infecte	VBN
cord-334133-61om170g	372	15	cells	cell	NNS
cord-334133-61om170g	372	16	to	to	TO
cord-334133-61om170g	372	17	evade	evade	VB
cord-334133-61om170g	372	18	the	the	DT
cord-334133-61om170g	372	19	immune	immune	JJ
cord-334133-61om170g	372	20	system	system	NN
cord-334133-61om170g	372	21	or	or	CC
cord-334133-61om170g	372	22	to	to	TO
cord-334133-61om170g	372	23	avoid	avoid	VB
cord-334133-61om170g	372	24	gp41-induced	gp41-induce	VBN
cord-334133-61om170g	372	25	cytotoxicity	cytotoxicity	NN
cord-334133-61om170g	372	26	.	.	.
cord-334133-61om170g	373	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	373	2	gp41	gp41	NNP
cord-334133-61om170g	373	3	sequences	sequence	NNS
cord-334133-61om170g	373	4	from	from	IN
cord-334133-61om170g	373	5	infectious	infectious	JJ
cord-334133-61om170g	373	6	viruses	virus	NNS
cord-334133-61om170g	373	7	,	,	,
cord-334133-61om170g	373	8	molecular	molecular	JJ
cord-334133-61om170g	373	9	clones	clone	NNS
cord-334133-61om170g	373	10	,	,	,
cord-334133-61om170g	373	11	and	and	CC
cord-334133-61om170g	373	12	PCR	PCR	NNP
cord-334133-61om170g	373	13	products	product	NNS
cord-334133-61om170g	373	14	from	from	IN
cord-334133-61om170g	373	15	blood	blood	NN
cord-334133-61om170g	373	16	samples	sample	NNS
cord-334133-61om170g	373	17	from	from	IN
cord-334133-61om170g	373	18	infected	infected	JJ
cord-334133-61om170g	373	19	individuals	individual	NNS
cord-334133-61om170g	373	20	were	be	VBD
cord-334133-61om170g	373	21	obtained	obtain	VBN
cord-334133-61om170g	373	22	from	from	IN
cord-334133-61om170g	373	23	http://hiv-web.lanl.gov/.	http://hiv-web.lanl.gov/.	NNP
cord-334133-61om170g	374	1	We	-PRON-	PRP
cord-334133-61om170g	374	2	analyzed	analyze	VBD
cord-334133-61om170g	374	3	residues	residue	NNS
cord-334133-61om170g	374	4	690	690	CD
cord-334133-61om170g	374	5	-	-	SYM
cord-334133-61om170g	374	6	793	793	CD
cord-334133-61om170g	374	7	of	of	IN
cord-334133-61om170g	374	8	HIV-1	HIV-1	NNP
cord-334133-61om170g	374	9	(	(	-LRB-
cord-334133-61om170g	374	10	numbering	number	VBG
cord-334133-61om170g	374	11	according	accord	VBG
cord-334133-61om170g	374	12	to	to	IN
cord-334133-61om170g	374	13	Ratner	Ratner	NNP
cord-334133-61om170g	374	14	et	et	NNP
cord-334133-61om170g	374	15	al	al	NNP
cord-334133-61om170g	374	16	.	.	NNP
cord-334133-61om170g	374	17	,	,	,
cord-334133-61om170g	374	18	1985	1985	CD
cord-334133-61om170g	374	19	)	)	-RRB-
cord-334133-61om170g	374	20	of	of	IN
cord-334133-61om170g	374	21	the	the	DT
cord-334133-61om170g	374	22	following	following	JJ
cord-334133-61om170g	374	23	number	number	NN
cord-334133-61om170g	374	24	of	of	IN
cord-334133-61om170g	374	25	sequences	sequence	NNS
cord-334133-61om170g	374	26	:	:	:
cord-334133-61om170g	375	1	clade	clade	NNP
cord-334133-61om170g	375	2	A	A	NNP
cord-334133-61om170g	375	3	,	,	,
cord-334133-61om170g	375	4	n	n	NN
cord-334133-61om170g	375	5	=	=	SYM
cord-334133-61om170g	375	6	25	25	CD
cord-334133-61om170g	375	7	;	;	,
cord-334133-61om170g	375	8	clade	clade	NN
cord-334133-61om170g	375	9	B	b	NN
cord-334133-61om170g	375	10	,	,	,
cord-334133-61om170g	375	11	n	n	NN
cord-334133-61om170g	375	12	=	=	SYM
cord-334133-61om170g	375	13	245	245	CD
cord-334133-61om170g	375	14	;	;	:
cord-334133-61om170g	375	15	clade	clade	NN
cord-334133-61om170g	375	16	C	C	NNP
cord-334133-61om170g	375	17	,	,	,
cord-334133-61om170g	375	18	n	n	NN
cord-334133-61om170g	375	19	=	=	SYM
cord-334133-61om170g	375	20	61	61	CD
cord-334133-61om170g	375	21	;	;	,
cord-334133-61om170g	375	22	clade	clade	NN
cord-334133-61om170g	375	23	D	D	NNP
cord-334133-61om170g	375	24	,	,	,
cord-334133-61om170g	375	25	n	n	NN
cord-334133-61om170g	375	26	=	=	SYM
cord-334133-61om170g	375	27	26	26	CD
cord-334133-61om170g	375	28	.	.	.
cord-334133-61om170g	376	1	The	the	DT
cord-334133-61om170g	376	2	sequence	sequence	NN
cord-334133-61om170g	376	3	analyzed	analyze	VBD
cord-334133-61om170g	376	4	comprises	comprise	VBZ
cord-334133-61om170g	376	5	the	the	DT
cord-334133-61om170g	376	6	MSD	MSD	NNP
cord-334133-61om170g	376	7	and	and	CC
cord-334133-61om170g	376	8	approximately	approximately	RB
cord-334133-61om170g	376	9	two	two	CD
cord-334133-61om170g	376	10	thirds	third	NNS
cord-334133-61om170g	376	11	of	of	IN
cord-334133-61om170g	376	12	the	the	DT
cord-334133-61om170g	376	13	C	C	NNP
cord-334133-61om170g	376	14	-	-	HYPH
cord-334133-61om170g	376	15	terminal	terminal	NN
cord-334133-61om170g	376	16	tail	tail	NN
cord-334133-61om170g	376	17	.	.	.
cord-334133-61om170g	377	1	Conserved	conserved	JJ
cord-334133-61om170g	377	2	regions	region	NNS
cord-334133-61om170g	377	3	of	of	IN
cord-334133-61om170g	377	4	sequence	sequence	NN
cord-334133-61om170g	377	5	were	be	VBD
cord-334133-61om170g	377	6	aligned	align	VBN
cord-334133-61om170g	377	7	,	,	,
cord-334133-61om170g	377	8	with	with	IN
cord-334133-61om170g	377	9	spaces	space	NNS
cord-334133-61om170g	377	10	as	as	IN
cord-334133-61om170g	377	11	necessary	necessary	JJ
cord-334133-61om170g	377	12	to	to	TO
cord-334133-61om170g	377	13	maintain	maintain	VB
cord-334133-61om170g	377	14	alignment	alignment	NN
cord-334133-61om170g	377	15	.	.	.
cord-334133-61om170g	378	1	The	the	DT
cord-334133-61om170g	378	2	residue	residue	NN
cord-334133-61om170g	378	3	occupying	occupy	VBG
cord-334133-61om170g	378	4	each	each	DT
cord-334133-61om170g	378	5	position	position	NN
cord-334133-61om170g	378	6	was	be	VBD
cord-334133-61om170g	378	7	recorded	record	VBN
cord-334133-61om170g	378	8	as	as	IN
cord-334133-61om170g	378	9	a	a	DT
cord-334133-61om170g	378	10	percentage	percentage	NN
cord-334133-61om170g	378	11	,	,	,
cord-334133-61om170g	378	12	and	and	CC
cord-334133-61om170g	378	13	consensus	consensus	NN
cord-334133-61om170g	378	14	sequences	sequence	NNS
cord-334133-61om170g	378	15	constructed	construct	VBN
cord-334133-61om170g	378	16	for	for	IN
cord-334133-61om170g	378	17	each	each	DT
cord-334133-61om170g	378	18	clade	clade	NN
cord-334133-61om170g	378	19	.	.	.
cord-334133-61om170g	379	1	Sequence	sequence	NN
cord-334133-61om170g	379	2	conservation	conservation	NN
cord-334133-61om170g	379	3	is	be	VBZ
cord-334133-61om170g	379	4	defined	define	VBN
cord-334133-61om170g	379	5	here	here	RB
cord-334133-61om170g	379	6	as	as	IN
cord-334133-61om170g	379	7	poor	poor	JJ
cord-334133-61om170g	379	8	(	(	-LRB-
cord-334133-61om170g	379	9	<	<	XX
cord-334133-61om170g	379	10	80	80	CD
cord-334133-61om170g	379	11	%	%	NN
cord-334133-61om170g	379	12	)	)	-RRB-
cord-334133-61om170g	379	13	,	,	,
cord-334133-61om170g	379	14	moderate	moderate	JJ
cord-334133-61om170g	379	15	(	(	-LRB-
cord-334133-61om170g	379	16	80	80	CD
cord-334133-61om170g	379	17	-89.9	-89.9	CD
cord-334133-61om170g	379	18	%	%	NN
cord-334133-61om170g	379	19	)	)	-RRB-
cord-334133-61om170g	379	20	,	,	,
cord-334133-61om170g	379	21	high	high	JJ
cord-334133-61om170g	379	22	(	(	-LRB-
cord-334133-61om170g	379	23	90	90	CD
cord-334133-61om170g	379	24	-96.4	-96.4	CD
cord-334133-61om170g	379	25	%	%	NN
cord-334133-61om170g	379	26	)	)	-RRB-
cord-334133-61om170g	379	27	,	,	,
cord-334133-61om170g	379	28	and	and	CC
cord-334133-61om170g	379	29	very	very	RB
cord-334133-61om170g	379	30	high	high	JJ
cord-334133-61om170g	379	31	(	(	-LRB-
cord-334133-61om170g	379	32	96.5	96.5	CD
cord-334133-61om170g	379	33	-100	-100	NN
cord-334133-61om170g	379	34	%	%	NN
cord-334133-61om170g	379	35	)	)	-RRB-
cord-334133-61om170g	379	36	.	.	.
cord-334133-61om170g	380	1	For	for	IN
cord-334133-61om170g	380	2	structure	structure	NN
cord-334133-61om170g	380	3	predications	predication	NNS
cord-334133-61om170g	380	4	we	-PRON-	PRP
cord-334133-61om170g	380	5	used	use	VBD
cord-334133-61om170g	380	6	the	the	DT
cord-334133-61om170g	380	7	consensus	consensus	NN
cord-334133-61om170g	380	8	sequences	sequence	NNS
cord-334133-61om170g	380	9	derived	derive	VBN
cord-334133-61om170g	380	10	in	in	IN
cord-334133-61om170g	380	11	this	this	DT
cord-334133-61om170g	380	12	report	report	NN
cord-334133-61om170g	380	13	for	for	IN
cord-334133-61om170g	380	14	the	the	DT
cord-334133-61om170g	380	15	gp41	gp41	NNP
cord-334133-61om170g	380	16	MSD	MSD	NNP
cord-334133-61om170g	380	17	and	and	CC
cord-334133-61om170g	380	18	Cterminal	Cterminal	NNP
cord-334133-61om170g	380	19	region	region	NN
cord-334133-61om170g	380	20	of	of	IN
cord-334133-61om170g	381	1	HIV-1	HIV-1	NNP
cord-334133-61om170g	381	2	clades	clade	NNS
cord-334133-61om170g	381	3	A	a	DT
cord-334133-61om170g	381	4	to	to	IN
cord-334133-61om170g	382	1	D.	D.	NNP
cord-334133-61om170g	382	2	Hydropathy	Hydropathy	NNP
cord-334133-61om170g	382	3	values	value	NNS
cord-334133-61om170g	382	4	assigned	assign	VBN
cord-334133-61om170g	382	5	to	to	IN
cord-334133-61om170g	382	6	the	the	DT
cord-334133-61om170g	382	7	amino	amino	NN
cord-334133-61om170g	382	8	acids	acid	NNS
cord-334133-61om170g	382	9	are	be	VBP
cord-334133-61om170g	382	10	based	base	VBN
cord-334133-61om170g	382	11	on	on	IN
cord-334133-61om170g	382	12	water	water	NN
cord-334133-61om170g	382	13	vapor	vapor	NN
cord-334133-61om170g	382	14	transfer	transfer	NN
cord-334133-61om170g	382	15	free	free	JJ
cord-334133-61om170g	382	16	energies	energy	NNS
cord-334133-61om170g	382	17	and	and	CC
cord-334133-61om170g	382	18	the	the	DT
cord-334133-61om170g	382	19	interior	interior	JJ
cord-334133-61om170g	382	20	-exterior	-exterior	NN
cord-334133-61om170g	382	21	distribution	distribution	NN
cord-334133-61om170g	382	22	of	of	IN
cord-334133-61om170g	382	23	amino	amino	NN
cord-334133-61om170g	382	24	acid	acid	NN
cord-334133-61om170g	382	25	side	side	NN
cord-334133-61om170g	382	26	chains	chain	NNS
cord-334133-61om170g	382	27	(	(	-LRB-
cord-334133-61om170g	382	28	Kyte	Kyte	NNP
cord-334133-61om170g	382	29	and	and	CC
cord-334133-61om170g	382	30	Doolittle	Doolittle	NNP
cord-334133-61om170g	382	31	,	,	,
cord-334133-61om170g	382	32	1982	1982	CD
cord-334133-61om170g	382	33	)	)	-RRB-
cord-334133-61om170g	382	34	.	.	.
cord-334133-61om170g	383	1	This	this	DT
cord-334133-61om170g	383	2	system	system	NN
cord-334133-61om170g	383	3	predicts	predict	VBZ
cord-334133-61om170g	383	4	that	that	IN
cord-334133-61om170g	383	5	a	a	DT
cord-334133-61om170g	383	6	region	region	NN
cord-334133-61om170g	383	7	with	with	IN
cord-334133-61om170g	383	8	a	a	DT
cord-334133-61om170g	383	9	value	value	NN
cord-334133-61om170g	383	10	>	>	XX
cord-334133-61om170g	383	11	1.6	1.6	CD
cord-334133-61om170g	383	12	is	be	VBZ
cord-334133-61om170g	383	13	likely	likely	JJ
cord-334133-61om170g	383	14	to	to	TO
cord-334133-61om170g	383	15	be	be	VB
cord-334133-61om170g	383	16	an	an	DT
cord-334133-61om170g	383	17	MSD	msd	NN
cord-334133-61om170g	383	18	,	,	,
cord-334133-61om170g	383	19	and	and	CC
cord-334133-61om170g	383	20	that	that	IN
cord-334133-61om170g	383	21	a	a	DT
cord-334133-61om170g	383	22	region	region	NN
cord-334133-61om170g	383	23	with	with	IN
cord-334133-61om170g	383	24	a	a	DT
cord-334133-61om170g	383	25	value	value	NN
cord-334133-61om170g	383	26	>	>	XX
cord-334133-61om170g	383	27	1.09	1.09	CD
cord-334133-61om170g	383	28	is	be	VBZ
cord-334133-61om170g	383	29	likely	likely	JJ
cord-334133-61om170g	383	30	to	to	TO
cord-334133-61om170g	383	31	be	be	VB
cord-334133-61om170g	383	32	sequestered	sequester	VBN
cord-334133-61om170g	383	33	inside	inside	IN
cord-334133-61om170g	383	34	the	the	DT
cord-334133-61om170g	383	35	protein	protein	NN
cord-334133-61om170g	383	36	.	.	.
cord-334133-61om170g	384	1	a	a	LS
cord-334133-61om170g	384	2	-	-	:
cord-334133-61om170g	384	3	Helices	Helices	NNPS
cord-334133-61om170g	384	4	and	and	CC
cord-334133-61om170g	384	5	h	h	NN
cord-334133-61om170g	384	6	-	-	HYPH
cord-334133-61om170g	384	7	sheets	sheet	NNS
cord-334133-61om170g	384	8	were	be	VBD
cord-334133-61om170g	384	9	predicted	predict	VBN
cord-334133-61om170g	384	10	according	accord	VBG
cord-334133-61om170g	384	11	to	to	IN
cord-334133-61om170g	384	12	Chou	Chou	NNP
cord-334133-61om170g	384	13	and	and	CC
cord-334133-61om170g	384	14	Fasman	Fasman	NNP
cord-334133-61om170g	384	15	(	(	-LRB-
cord-334133-61om170g	384	16	1978	1978	CD
cord-334133-61om170g	384	17	)	)	-RRB-
cord-334133-61om170g	384	18	,	,	,
cord-334133-61om170g	384	19	where	where	WRB
cord-334133-61om170g	384	20	P	p	NN
cord-334133-61om170g	384	21	a	a	NN
cord-334133-61om170g	384	22	is	be	VBZ
cord-334133-61om170g	384	23	the	the	DT
cord-334133-61om170g	384	24	helix	helix	NN
cord-334133-61om170g	384	25	conformational	conformational	JJ
cord-334133-61om170g	384	26	parameter	parameter	NN
cord-334133-61om170g	384	27	and	and	CC
cord-334133-61om170g	384	28	P	p	NN
cord-334133-61om170g	384	29	h	h	NNP
cord-334133-61om170g	384	30	is	be	VBZ
cord-334133-61om170g	384	31	the	the	DT
cord-334133-61om170g	384	32	h	h	NN
cord-334133-61om170g	384	33	-	-	HYPH
cord-334133-61om170g	384	34	sheet	sheet	NN
cord-334133-61om170g	384	35	conformational	conformational	JJ
cord-334133-61om170g	384	36	parameter	parameter	NN
cord-334133-61om170g	384	37	.	.	.
cord-334133-61om170g	385	1	Any	any	DT
cord-334133-61om170g	385	2	segment	segment	NN
cord-334133-61om170g	385	3	of	of	IN
cord-334133-61om170g	385	4	!	!	.
cord-334133-61om170g	386	1	6	6	CD
cord-334133-61om170g	386	2	residues	residue	NNS
cord-334133-61om170g	386	3	with	with	IN
cord-334133-61om170g	386	4	(	(	-LRB-
cord-334133-61om170g	386	5	P	p	NN
cord-334133-61om170g	386	6	a	a	NN
cord-334133-61om170g	386	7	)	)	-RRB-
cord-334133-61om170g	386	8	!	!	.
cord-334133-61om170g	386	9	1.03	1.03	CD
cord-334133-61om170g	386	10	and	and	CC
cord-334133-61om170g	386	11	(	(	-LRB-
cord-334133-61om170g	386	12	P	p	NN
cord-334133-61om170g	386	13	a	a	LS
cord-334133-61om170g	386	14	)	)	-RRB-
cord-334133-61om170g	386	15	>	>	XX
cord-334133-61om170g	387	1	(	(	-LRB-
cord-334133-61om170g	387	2	P	p	NN
cord-334133-61om170g	387	3	h	h	NN
cord-334133-61om170g	387	4	)	)	-RRB-
cord-334133-61om170g	387	5	is	be	VBZ
cord-334133-61om170g	387	6	predicted	predict	VBN
cord-334133-61om170g	387	7	to	to	TO
cord-334133-61om170g	387	8	be	be	VB
cord-334133-61om170g	387	9	aÀhelical	aÀhelical	NNP
cord-334133-61om170g	387	10	,	,	,
cord-334133-61om170g	387	11	and	and	CC
cord-334133-61om170g	387	12	any	any	DT
cord-334133-61om170g	387	13	segment	segment	NN
cord-334133-61om170g	387	14	of	of	IN
cord-334133-61om170g	387	15	three	three	CD
cord-334133-61om170g	387	16	residues	residue	NNS
cord-334133-61om170g	387	17	or	or	CC
cord-334133-61om170g	387	18	longer	long	JJR
cord-334133-61om170g	387	19	in	in	IN
cord-334133-61om170g	387	20	a	a	DT
cord-334133-61om170g	387	21	native	native	JJ
cord-334133-61om170g	387	22	protein	protein	NN
cord-334133-61om170g	387	23	with	with	IN
cord-334133-61om170g	387	24	(	(	-LRB-
cord-334133-61om170g	387	25	P	p	NN
cord-334133-61om170g	387	26	h	h	NN
cord-334133-61om170g	387	27	)	)	-RRB-
cord-334133-61om170g	387	28	!	!	.
cord-334133-61om170g	388	1	1.05	1.05	CD
cord-334133-61om170g	388	2	and	and	CC
cord-334133-61om170g	388	3	(	(	-LRB-
cord-334133-61om170g	388	4	P	p	NN
cord-334133-61om170g	388	5	h	h	NN
cord-334133-61om170g	388	6	)	)	-RRB-
cord-334133-61om170g	389	1	>	>	XX
cord-334133-61om170g	390	1	(	(	-LRB-
cord-334133-61om170g	390	2	P	p	NN
cord-334133-61om170g	390	3	a	a	LS
cord-334133-61om170g	390	4	)	)	-RRB-
cord-334133-61om170g	390	5	is	be	VBZ
cord-334133-61om170g	390	6	predicted	predict	VBN
cord-334133-61om170g	390	7	to	to	TO
cord-334133-61om170g	390	8	be	be	VB
cord-334133-61om170g	390	9	h	h	NN
cord-334133-61om170g	390	10	-	-	HYPH
cord-334133-61om170g	390	11	sheet	sheet	NN
cord-334133-61om170g	390	12	.	.	.
cord-334133-61om170g	391	1	A	a	DT
cord-334133-61om170g	391	2	segment	segment	NN
cord-334133-61om170g	391	3	containing	contain	VBG
cord-334133-61om170g	391	4	overlapping	overlap	VBG
cord-334133-61om170g	391	5	aand	aand	NNP
cord-334133-61om170g	391	6	hresidues	hresidues	NNP
cord-334133-61om170g	391	7	is	be	VBZ
cord-334133-61om170g	391	8	resolved	resolve	VBN
cord-334133-61om170g	391	9	through	through	IN
cord-334133-61om170g	391	10	conformational	conformational	JJ
cord-334133-61om170g	391	11	boundary	boundary	JJ
cord-334133-61om170g	391	12	analysis	analysis	NN
cord-334133-61om170g	391	13	so	so	IN
cord-334133-61om170g	391	14	that	that	DT
cord-334133-61om170g	391	15	(	(	-LRB-
cord-334133-61om170g	391	16	P	p	NN
cord-334133-61om170g	391	17	a	a	LS
cord-334133-61om170g	391	18	)	)	-RRB-
cord-334133-61om170g	391	19	>	>	XX
cord-334133-61om170g	392	1	(	(	-LRB-
cord-334133-61om170g	392	2	P	p	NN
cord-334133-61om170g	392	3	h	h	NN
cord-334133-61om170g	392	4	)	)	-RRB-
cord-334133-61om170g	392	5	is	be	VBZ
cord-334133-61om170g	392	6	a	a	DT
cord-334133-61om170g	392	7	-	-	HYPH
cord-334133-61om170g	392	8	helical	helical	JJ
cord-334133-61om170g	392	9	,	,	,
cord-334133-61om170g	392	10	and	and	CC
cord-334133-61om170g	392	11	(	(	-LRB-
cord-334133-61om170g	392	12	P	p	NN
cord-334133-61om170g	392	13	h	h	NN
cord-334133-61om170g	392	14	)	)	-RRB-
cord-334133-61om170g	393	1	>	>	XX
cord-334133-61om170g	394	1	(	(	-LRB-
cord-334133-61om170g	394	2	P	p	NN
cord-334133-61om170g	394	3	a	a	LS
cord-334133-61om170g	394	4	)	)	-RRB-
cord-334133-61om170g	394	5	is	be	VBZ
cord-334133-61om170g	394	6	h	h	NN
cord-334133-61om170g	394	7	-	-	HYPH
cord-334133-61om170g	394	8	sheet	sheet	NN
cord-334133-61om170g	394	9	.	.	.
cord-334133-61om170g	395	1	A	a	DT
cord-334133-61om170g	395	2	h	h	NN
cord-334133-61om170g	395	3	-	-	HYPH
cord-334133-61om170g	395	4	turn	turn	NN
cord-334133-61om170g	395	5	occurs	occur	VBZ
cord-334133-61om170g	395	6	where	where	WRB
cord-334133-61om170g	395	7	a	a	DT
cord-334133-61om170g	395	8	polypeptide	polypeptide	NN
cord-334133-61om170g	395	9	folds	fold	VBZ
cord-334133-61om170g	395	10	back	back	RB
cord-334133-61om170g	395	11	on	on	IN
cord-334133-61om170g	395	12	itself	-PRON-	PRP
cord-334133-61om170g	395	13	by	by	IN
cord-334133-61om170g	395	14	nearly	nearly	RB
cord-334133-61om170g	395	15	180-and	180-and	CD
cord-334133-61om170g	395	16	typically	typically	RB
cord-334133-61om170g	395	17	requires	require	VBZ
cord-334133-61om170g	395	18	four	four	CD
cord-334133-61om170g	395	19	consecutive	consecutive	JJ
cord-334133-61om170g	395	20	residues	residue	NNS
cord-334133-61om170g	395	21	(	(	-LRB-
cord-334133-61om170g	395	22	Chou	Chou	NNP
cord-334133-61om170g	395	23	and	and	CC
cord-334133-61om170g	395	24	Fasman	Fasman	NNP
cord-334133-61om170g	395	25	,	,	,
cord-334133-61om170g	395	26	1978	1978	CD
cord-334133-61om170g	395	27	)	)	-RRB-
cord-334133-61om170g	395	28	.	.	.
cord-334133-61om170g	396	1	However	however	RB
cord-334133-61om170g	396	2	,	,	,
cord-334133-61om170g	396	3	a	a	DT
cord-334133-61om170g	396	4	h	h	NN
cord-334133-61om170g	396	5	-	-	HYPH
cord-334133-61om170g	396	6	turn	turn	NN
cord-334133-61om170g	396	7	of	of	IN
cord-334133-61om170g	396	8	two	two	CD
cord-334133-61om170g	396	9	residues	residue	NNS
cord-334133-61om170g	396	10	occurs	occur	VBZ
cord-334133-61om170g	396	11	between	between	IN
cord-334133-61om170g	396	12	two	two	CD
cord-334133-61om170g	396	13	MSDs	msd	NNS
cord-334133-61om170g	396	14	of	of	IN
cord-334133-61om170g	396	15	herpes	herpes	NNP
cord-334133-61om170g	396	16	simplex	simplex	NNP
cord-334133-61om170g	396	17	virus	virus	NN
cord-334133-61om170g	396	18	glycoprotein	glycoprotein	NN
cord-334133-61om170g	396	19	B	b	NN
cord-334133-61om170g	396	20	(	(	-LRB-
cord-334133-61om170g	396	21	Pellett	Pellett	NNP
cord-334133-61om170g	396	22	et	et	FW
cord-334133-61om170g	396	23	al	al	NNP
cord-334133-61om170g	396	24	.	.	NNP
cord-334133-61om170g	396	25	,	,	,
cord-334133-61om170g	396	26	1985	1985	CD
cord-334133-61om170g	396	27	)	)	-RRB-
cord-334133-61om170g	396	28	.	.	.
cord-334133-61om170g	397	1	The	the	DT
cord-334133-61om170g	397	2	lower	lower	RBR
cord-334133-61om170g	397	3	cut	cut	VB
cord-334133-61om170g	397	4	-	-	HYPH
cord-334133-61om170g	397	5	off	off	RP
cord-334133-61om170g	397	6	value	value	NN
cord-334133-61om170g	397	7	for	for	IN
cord-334133-61om170g	397	8	h	h	NN
cord-334133-61om170g	397	9	-	-	HYPH
cord-334133-61om170g	397	10	turns	turn	NNS
cord-334133-61om170g	397	11	of	of	IN
cord-334133-61om170g	397	12	0.75	0.75	CD
cord-334133-61om170g	397	13	was	be	VBD
cord-334133-61om170g	397	14	used	use	VBN
cord-334133-61om170g	397	15	here	here	RB
cord-334133-61om170g	398	1	(	(	-LRB-
cord-334133-61om170g	398	2	Chou	Chou	NNP
cord-334133-61om170g	398	3	and	and	CC
cord-334133-61om170g	398	4	Fasman	Fasman	NNP
cord-334133-61om170g	398	5	,	,	,
cord-334133-61om170g	398	6	1978	1978	CD
cord-334133-61om170g	398	7	)	)	-RRB-
cord-334133-61om170g	398	8	.	.	.
cord-334133-61om170g	399	1	Polarity	polarity	NN
cord-334133-61om170g	399	2	was	be	VBD
cord-334133-61om170g	399	3	determined	determine	VBN
cord-334133-61om170g	399	4	according	accord	VBG
cord-334133-61om170g	399	5	to	to	IN
cord-334133-61om170g	399	6	Zimmerman	Zimmerman	NNP
cord-334133-61om170g	399	7	et	et	NNP
cord-334133-61om170g	399	8	al	al	NNP
cord-334133-61om170g	399	9	.	.	.
cord-334133-61om170g	400	1	(	(	-LRB-
cord-334133-61om170g	400	2	1968	1968	CD
cord-334133-61om170g	400	3	)	)	-RRB-
cord-334133-61om170g	400	4	.	.	.
cord-334133-61om170g	401	1	Accessibility	accessibility	NN
cord-334133-61om170g	401	2	of	of	IN
cord-334133-61om170g	401	3	a	a	DT
cord-334133-61om170g	401	4	region	region	NN
cord-334133-61om170g	401	5	of	of	IN
cord-334133-61om170g	401	6	a	a	DT
cord-334133-61om170g	401	7	protein	protein	NN
cord-334133-61om170g	401	8	to	to	IN
cord-334133-61om170g	401	9	solvent	solvent	NN
cord-334133-61om170g	401	10	was	be	VBD
cord-334133-61om170g	401	11	predicated	predicate	VBN
cord-334133-61om170g	401	12	using	use	VBG
cord-334133-61om170g	401	13	the	the	DT
cord-334133-61om170g	401	14	percentage	percentage	NN
cord-334133-61om170g	401	15	buried	bury	VBN
cord-334133-61om170g	401	16	residues	residue	NNS
cord-334133-61om170g	401	17	index	index	NN
cord-334133-61om170g	401	18	(	(	-LRB-
cord-334133-61om170g	401	19	Janin	Janin	NNP
cord-334133-61om170g	401	20	,	,	,
cord-334133-61om170g	401	21	1979	1979	CD
cord-334133-61om170g	401	22	)	)	-RRB-
cord-334133-61om170g	401	23	.	.	.
cord-334133-61om170g	402	1	Low	low	JJ
cord-334133-61om170g	402	2	values	value	NNS
cord-334133-61om170g	402	3	indicate	indicate	VBP
cord-334133-61om170g	402	4	a	a	DT
cord-334133-61om170g	402	5	region	region	NN
cord-334133-61om170g	402	6	that	that	WDT
cord-334133-61om170g	402	7	is	be	VBZ
cord-334133-61om170g	402	8	likely	likely	JJ
cord-334133-61om170g	402	9	to	to	TO
cord-334133-61om170g	402	10	be	be	VB
cord-334133-61om170g	402	11	accessible	accessible	JJ
cord-334133-61om170g	402	12	to	to	IN
cord-334133-61om170g	402	13	solvent	solvent	NN
cord-334133-61om170g	402	14	and	and	CC
cord-334133-61om170g	402	15	hence	hence	RB
cord-334133-61om170g	402	16	surface	surface	NN
cord-334133-61om170g	402	17	exposed	expose	VBN
cord-334133-61om170g	402	18	,	,	,
cord-334133-61om170g	402	19	and	and	CC
cord-334133-61om170g	402	20	high	high	JJ
cord-334133-61om170g	402	21	values	value	NNS
cord-334133-61om170g	402	22	indicate	indicate	VBP
cord-334133-61om170g	402	23	regions	region	NNS
cord-334133-61om170g	402	24	not	not	RB
cord-334133-61om170g	402	25	accessible	accessible	JJ
cord-334133-61om170g	402	26	to	to	IN
cord-334133-61om170g	402	27	the	the	DT
cord-334133-61om170g	402	28	solvent	solvent	NN
cord-334133-61om170g	402	29	.	.	.
cord-334133-61om170g	403	1	Predications	predication	NNS
cord-334133-61om170g	403	2	used	use	VBD
cord-334133-61om170g	403	3	a	a	DT
cord-334133-61om170g	403	4	moving	move	VBG
cord-334133-61om170g	403	5	window	window	NN
cord-334133-61om170g	403	6	of	of	IN
cord-334133-61om170g	403	7	7	7	CD
cord-334133-61om170g	403	8	residues	residue	NNS
cord-334133-61om170g	403	9	.	.	.
cord-334133-61om170g	404	1	Membrane	membrane	NN
cord-334133-61om170g	404	2	permeabilization	permeabilization	NN
cord-334133-61om170g	404	3	by	by	IN
cord-334133-61om170g	404	4	different	different	JJ
cord-334133-61om170g	404	5	regions	region	NNS
cord-334133-61om170g	404	6	of	of	IN
cord-334133-61om170g	404	7	the	the	DT
cord-334133-61om170g	404	8	human	human	JJ
cord-334133-61om170g	404	9	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	404	10	virus	virus	NN
cord-334133-61om170g	404	11	type	type	NN
cord-334133-61om170g	404	12	1	1	CD
cord-334133-61om170g	404	13	transmembrane	transmembrane	NN
cord-334133-61om170g	404	14	glycoprotein	glycoprotein	NN
cord-334133-61om170g	404	15	gp41	gp41	NNP
cord-334133-61om170g	404	16	Interactions	Interactions	NNPS
cord-334133-61om170g	404	17	of	of	IN
cord-334133-61om170g	404	18	the	the	DT
cord-334133-61om170g	404	19	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	404	20	domains	domain	NNS
cord-334133-61om170g	404	21	of	of	IN
cord-334133-61om170g	404	22	human	human	JJ
cord-334133-61om170g	404	23	and	and	CC
cord-334133-61om170g	404	24	simian	simian	JJ
cord-334133-61om170g	404	25	retroviral	retroviral	NN
cord-334133-61om170g	404	26	transmembrane	transmembrane	NN
cord-334133-61om170g	404	27	proteins	protein	NNS
cord-334133-61om170g	404	28	with	with	IN
cord-334133-61om170g	404	29	components	component	NNS
cord-334133-61om170g	404	30	of	of	IN
cord-334133-61om170g	404	31	the	the	DT
cord-334133-61om170g	404	32	clathrin	clathrin	NN
cord-334133-61om170g	404	33	adapter	adapter	NN
cord-334133-61om170g	404	34	complexes	complex	NNS
cord-334133-61om170g	404	35	modulate	modulate	VBP
cord-334133-61om170g	404	36	intracellular	intracellular	JJ
cord-334133-61om170g	404	37	and	and	CC
cord-334133-61om170g	404	38	cell	cell	NN
cord-334133-61om170g	404	39	surface	surface	NN
cord-334133-61om170g	404	40	expression	expression	NN
cord-334133-61om170g	404	41	of	of	IN
cord-334133-61om170g	404	42	envelope	envelope	NN
cord-334133-61om170g	404	43	glycoprotein	glycoprotein	NN
cord-334133-61om170g	404	44	Expression	expression	NN
cord-334133-61om170g	404	45	of	of	IN
cord-334133-61om170g	404	46	human	human	JJ
cord-334133-61om170g	404	47	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	404	48	virus	virus	NN
cord-334133-61om170g	404	49	type	type	NN
cord-334133-61om170g	404	50	1	1	CD
cord-334133-61om170g	404	51	(	(	-LRB-
cord-334133-61om170g	404	52	HIV-1	HIV-1	NNP
cord-334133-61om170g	404	53	)	)	-RRB-
cord-334133-61om170g	404	54	envelope	envelope	NN
cord-334133-61om170g	404	55	gene	gene	NN
cord-334133-61om170g	404	56	products	product	NNS
cord-334133-61om170g	404	57	transcribed	transcribe	VBN
cord-334133-61om170g	404	58	from	from	IN
cord-334133-61om170g	404	59	a	a	DT
cord-334133-61om170g	404	60	heterologous	heterologous	JJ
cord-334133-61om170g	404	61	promoter	promoter	NN
cord-334133-61om170g	404	62	A	a	DT
cord-334133-61om170g	404	63	membraneproximal	membraneproximal	NN
cord-334133-61om170g	404	64	signal	signal	NN
cord-334133-61om170g	404	65	mediates	mediate	VBZ
cord-334133-61om170g	404	66	internalization	internalization	NN
cord-334133-61om170g	404	67	of	of	IN
cord-334133-61om170g	404	68	the	the	DT
cord-334133-61om170g	404	69	HIV-1	HIV-1	NNP
cord-334133-61om170g	404	70	envelope	envelope	NN
cord-334133-61om170g	404	71	glycoprotein	glycoprotein	NN
cord-334133-61om170g	404	72	via	via	IN
cord-334133-61om170g	404	73	interaction	interaction	NN
cord-334133-61om170g	404	74	with	with	IN
cord-334133-61om170g	404	75	the	the	DT
cord-334133-61om170g	404	76	AP-2	AP-2	NNP
cord-334133-61om170g	404	77	clathrin	clathrin	NN
cord-334133-61om170g	404	78	adaptor	adaptor	NN
cord-334133-61om170g	404	79	Sequence	sequence	NN
cord-334133-61om170g	404	80	requirements	requirement	NNS
cord-334133-61om170g	404	81	for	for	IN
cord-334133-61om170g	404	82	the	the	DT
cord-334133-61om170g	404	83	recognition	recognition	NN
cord-334133-61om170g	404	84	of	of	IN
cord-334133-61om170g	404	85	tyrosine	tyrosine	NN
cord-334133-61om170g	404	86	-	-	HYPH
cord-334133-61om170g	404	87	based	base	VBN
cord-334133-61om170g	404	88	endocytic	endocytic	JJ
cord-334133-61om170g	404	89	signals	signal	NNS
cord-334133-61om170g	404	90	by	by	IN
cord-334133-61om170g	404	91	clathrin	clathrin	NN
cord-334133-61om170g	404	92	AP-2	AP-2	NNP
cord-334133-61om170g	404	93	complexes	complex	NNS
cord-334133-61om170g	404	94	Enhancement	Enhancement	NNP
cord-334133-61om170g	404	95	of	of	IN
cord-334133-61om170g	404	96	immunogenicity	immunogenicity	NN
cord-334133-61om170g	404	97	of	of	IN
cord-334133-61om170g	404	98	an	an	DT
cord-334133-61om170g	404	99	HIV	HIV	NNP
cord-334133-61om170g	404	100	Env	Env	NNP
cord-334133-61om170g	404	101	DNA	DNA	NNP
cord-334133-61om170g	404	102	vaccine	vaccine	NN
cord-334133-61om170g	404	103	by	by	IN
cord-334133-61om170g	404	104	mutation	mutation	NN
cord-334133-61om170g	404	105	of	of	IN
cord-334133-61om170g	404	106	the	the	DT
cord-334133-61om170g	404	107	Tyr	Tyr	NNP
cord-334133-61om170g	404	108	-	-	HYPH
cord-334133-61om170g	404	109	based	base	VBN
cord-334133-61om170g	404	110	endocytosis	endocytosis	NN
cord-334133-61om170g	404	111	motif	motif	NN
cord-334133-61om170g	404	112	in	in	IN
cord-334133-61om170g	404	113	the	the	DT
cord-334133-61om170g	404	114	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	404	115	tail	tail	NN
cord-334133-61om170g	404	116	Ubiquitination	Ubiquitination	NNP
cord-334133-61om170g	404	117	of	of	IN
cord-334133-61om170g	404	118	the	the	DT
cord-334133-61om170g	404	119	human	human	JJ
cord-334133-61om170g	404	120	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	404	121	virus	virus	NN
cord-334133-61om170g	404	122	type	type	NN
cord-334133-61om170g	404	123	1	1	CD
cord-334133-61om170g	404	124	Env	Env	NNP
cord-334133-61om170g	404	125	protein	protein	NN
cord-334133-61om170g	405	1	The	the	DT
cord-334133-61om170g	405	2	neutralizing	neutralize	VBG
cord-334133-61om170g	405	3	antibody	antibody	NN
cord-334133-61om170g	405	4	response	response	NN
cord-334133-61om170g	405	5	against	against	IN
cord-334133-61om170g	405	6	a	a	DT
cord-334133-61om170g	405	7	conserved	conserved	JJ
cord-334133-61om170g	405	8	region	region	NN
cord-334133-61om170g	405	9	of	of	IN
cord-334133-61om170g	405	10	HIV-1	HIV-1	NNP
cord-334133-61om170g	405	11	gp41	gp41	NNP
cord-334133-61om170g	405	12	(	(	-LRB-
cord-334133-61om170g	405	13	amino	amino	NN
cord-334133-61om170g	405	14	acid	acid	NN
cord-334133-61om170g	405	15	residues	residue	NNS
cord-334133-61om170g	405	16	731	731	CD
cord-334133-61om170g	405	17	-752	-752	NNS
cord-334133-61om170g	405	18	)	)	-RRB-
cord-334133-61om170g	405	19	is	be	VBZ
cord-334133-61om170g	405	20	uniquely	uniquely	RB
cord-334133-61om170g	405	21	directed	direct	VBN
cord-334133-61om170g	405	22	against	against	IN
cord-334133-61om170g	405	23	a	a	DT
cord-334133-61om170g	405	24	conformational	conformational	JJ
cord-334133-61om170g	405	25	epitope	epitope	NN
cord-334133-61om170g	405	26	Induction	Induction	NNP
cord-334133-61om170g	405	27	of	of	IN
cord-334133-61om170g	405	28	anti	anti	JJ
cord-334133-61om170g	405	29	-	-	JJ
cord-334133-61om170g	405	30	HIV	hiv	JJ
cord-334133-61om170g	405	31	neutralizing	neutralize	VBG
cord-334133-61om170g	405	32	antibodies	antibody	NNS
cord-334133-61om170g	405	33	by	by	IN
cord-334133-61om170g	405	34	synthetic	synthetic	JJ
cord-334133-61om170g	405	35	peptides	peptide	NNS
cord-334133-61om170g	406	1	An	an	DT
cord-334133-61om170g	406	2	amphipathic	amphipathic	JJ
cord-334133-61om170g	406	3	peptide	peptide	NN
cord-334133-61om170g	406	4	from	from	IN
cord-334133-61om170g	406	5	the	the	DT
cord-334133-61om170g	406	6	C	C	NNP
cord-334133-61om170g	406	7	-	-	HYPH
cord-334133-61om170g	406	8	terminal	terminal	NN
cord-334133-61om170g	406	9	region	region	NN
cord-334133-61om170g	406	10	of	of	IN
cord-334133-61om170g	406	11	the	the	DT
cord-334133-61om170g	406	12	human	human	JJ
cord-334133-61om170g	406	13	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	406	14	virus	virus	NN
cord-334133-61om170g	406	15	envelope	envelope	NN
cord-334133-61om170g	406	16	glycoprotein	glycoprotein	NN
cord-334133-61om170g	406	17	causes	cause	VBZ
cord-334133-61om170g	406	18	pore	pore	NN
cord-334133-61om170g	406	19	formation	formation	NN
cord-334133-61om170g	406	20	in	in	IN
cord-334133-61om170g	406	21	membranes	membrane	NNS
cord-334133-61om170g	406	22	Part	part	NN
cord-334133-61om170g	406	23	of	of	IN
cord-334133-61om170g	406	24	the	the	DT
cord-334133-61om170g	406	25	C	c	NN
cord-334133-61om170g	406	26	-	-	HYPH
cord-334133-61om170g	406	27	terminal	terminal	NN
cord-334133-61om170g	406	28	tail	tail	NN
cord-334133-61om170g	406	29	of	of	IN
cord-334133-61om170g	406	30	the	the	DT
cord-334133-61om170g	406	31	envelope	envelope	NN
cord-334133-61om170g	406	32	gp41	gp41	NN
cord-334133-61om170g	406	33	transmembrane	transmembrane	NN
cord-334133-61om170g	406	34	protein	protein	NN
cord-334133-61om170g	406	35	of	of	IN
cord-334133-61om170g	406	36	human	human	JJ
cord-334133-61om170g	406	37	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	406	38	virus	virus	NN
cord-334133-61om170g	406	39	type	type	NN
cord-334133-61om170g	406	40	1	1	CD
cord-334133-61om170g	407	1	(	(	-LRB-
cord-334133-61om170g	407	2	HIV-1	HIV-1	NNP
cord-334133-61om170g	407	3	)	)	-RRB-
cord-334133-61om170g	407	4	is	be	VBZ
cord-334133-61om170g	407	5	exposed	expose	VBN
cord-334133-61om170g	407	6	on	on	IN
cord-334133-61om170g	407	7	the	the	DT
cord-334133-61om170g	407	8	cell	cell	NN
cord-334133-61om170g	407	9	surface	surface	NN
cord-334133-61om170g	407	10	and	and	CC
cord-334133-61om170g	407	11	is	be	VBZ
cord-334133-61om170g	407	12	involved	involve	VBN
cord-334133-61om170g	407	13	in	in	IN
cord-334133-61om170g	407	14	virus	virus	NN
cord-334133-61om170g	407	15	-	-	HYPH
cord-334133-61om170g	407	16	mediated	mediate	VBN
cord-334133-61om170g	407	17	cell	cell	NN
cord-334133-61om170g	407	18	-	-	HYPH
cord-334133-61om170g	407	19	cell	cell	NN
cord-334133-61om170g	407	20	fusion	fusion	NN
cord-334133-61om170g	407	21	Prediction	Prediction	NNP
cord-334133-61om170g	407	22	of	of	IN
cord-334133-61om170g	407	23	the	the	DT
cord-334133-61om170g	407	24	secondary	secondary	JJ
cord-334133-61om170g	407	25	structure	structure	NN
cord-334133-61om170g	407	26	of	of	IN
cord-334133-61om170g	407	27	proteins	protein	NNS
cord-334133-61om170g	407	28	from	from	IN
cord-334133-61om170g	407	29	their	-PRON-	PRP$
cord-334133-61om170g	407	30	amino	amino	NN
cord-334133-61om170g	407	31	acid	acid	NN
cord-334133-61om170g	407	32	sequence	sequence	NN
cord-334133-61om170g	407	33	Immunogenic	immunogenic	JJ
cord-334133-61om170g	407	34	and	and	CC
cord-334133-61om170g	407	35	antigenic	antigenic	JJ
cord-334133-61om170g	407	36	dominance	dominance	NN
cord-334133-61om170g	407	37	of	of	IN
cord-334133-61om170g	407	38	a	a	DT
cord-334133-61om170g	407	39	non	non	JJ
cord-334133-61om170g	407	40	-	-	JJ
cord-334133-61om170g	407	41	neutralizing	neutralizing	JJ
cord-334133-61om170g	407	42	epitope	epitope	NN
cord-334133-61om170g	407	43	over	over	IN
cord-334133-61om170g	407	44	a	a	DT
cord-334133-61om170g	407	45	highly	highly	RB
cord-334133-61om170g	407	46	conserved	conserve	VBN
cord-334133-61om170g	407	47	neutralizing	neutralize	VBG
cord-334133-61om170g	407	48	epitope	epitope	NN
cord-334133-61om170g	407	49	in	in	IN
cord-334133-61om170g	407	50	the	the	DT
cord-334133-61om170g	407	51	gp41	gp41	NN
cord-334133-61om170g	407	52	transmembrane	transmembrane	NN
cord-334133-61om170g	407	53	envelope	envelope	NN
cord-334133-61om170g	407	54	glycoprotein	glycoprotein	NN
cord-334133-61om170g	407	55	of	of	IN
cord-334133-61om170g	407	56	HIV-1	HIV-1	NNP
cord-334133-61om170g	407	57	:	:	:
cord-334133-61om170g	407	58	its	-PRON-	PRP$
cord-334133-61om170g	407	59	deletion	deletion	NN
cord-334133-61om170g	407	60	leads	lead	VBZ
cord-334133-61om170g	407	61	to	to	IN
cord-334133-61om170g	407	62	a	a	DT
cord-334133-61om170g	407	63	strong	strong	JJ
cord-334133-61om170g	407	64	neutralizing	neutralize	VBG
cord-334133-61om170g	407	65	antibody	antibody	NN
cord-334133-61om170g	407	66	response	response	NN
cord-334133-61om170g	407	67	Properties	property	NNS
cord-334133-61om170g	407	68	of	of	IN
cord-334133-61om170g	407	69	a	a	DT
cord-334133-61om170g	407	70	neutralizing	neutralize	VBG
cord-334133-61om170g	407	71	antibody	antibody	NN
cord-334133-61om170g	407	72	that	that	WDT
cord-334133-61om170g	407	73	recognises	recognise	VBZ
cord-334133-61om170g	407	74	a	a	DT
cord-334133-61om170g	407	75	conformational	conformational	JJ
cord-334133-61om170g	407	76	form	form	NN
cord-334133-61om170g	407	77	of	of	IN
cord-334133-61om170g	407	78	epitope	epitope	NN
cord-334133-61om170g	407	79	ERDRD	ERDRD	NNP
cord-334133-61om170g	407	80	in	in	IN
cord-334133-61om170g	407	81	the	the	DT
cord-334133-61om170g	407	82	C	c	NN
cord-334133-61om170g	407	83	-	-	HYPH
cord-334133-61om170g	407	84	terminal	terminal	NN
cord-334133-61om170g	407	85	tail	tail	NN
cord-334133-61om170g	407	86	of	of	IN
cord-334133-61om170g	407	87	human	human	JJ
cord-334133-61om170g	407	88	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	407	89	virus	virus	NN
cord-334133-61om170g	407	90	type	type	NN
cord-334133-61om170g	408	1	1	1	LS
cord-334133-61om170g	408	2	A	a	DT
cord-334133-61om170g	408	3	region	region	NN
cord-334133-61om170g	408	4	of	of	IN
cord-334133-61om170g	408	5	the	the	DT
cord-334133-61om170g	408	6	C	C	NNP
cord-334133-61om170g	408	7	-	-	HYPH
cord-334133-61om170g	408	8	terminal	terminal	NN
cord-334133-61om170g	408	9	tail	tail	NN
cord-334133-61om170g	408	10	of	of	IN
cord-334133-61om170g	408	11	the	the	DT
cord-334133-61om170g	408	12	gp41	gp41	NNP
cord-334133-61om170g	408	13	envelope	envelope	NN
cord-334133-61om170g	408	14	glycoprotein	glycoprotein	NN
cord-334133-61om170g	408	15	of	of	IN
cord-334133-61om170g	408	16	human	human	JJ
cord-334133-61om170g	408	17	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	408	18	virus	virus	NN
cord-334133-61om170g	408	19	type	type	NN
cord-334133-61om170g	408	20	1	1	CD
cord-334133-61om170g	408	21	contains	contain	VBZ
cord-334133-61om170g	408	22	a	a	DT
cord-334133-61om170g	408	23	neutralizing	neutralize	VBG
cord-334133-61om170g	408	24	epitope	epitope	NN
cord-334133-61om170g	408	25	:	:	:
cord-334133-61om170g	408	26	evidence	evidence	NN
cord-334133-61om170g	408	27	for	for	IN
cord-334133-61om170g	408	28	its	-PRON-	PRP$
cord-334133-61om170g	408	29	exposure	exposure	NN
cord-334133-61om170g	408	30	on	on	IN
cord-334133-61om170g	408	31	the	the	DT
cord-334133-61om170g	408	32	surface	surface	NN
cord-334133-61om170g	408	33	of	of	IN
cord-334133-61om170g	408	34	the	the	DT
cord-334133-61om170g	408	35	virion	virion	NN
cord-334133-61om170g	408	36	Transferrin	Transferrin	NNP
cord-334133-61om170g	408	37	receptor	receptor	NN
cord-334133-61om170g	408	38	internalization	internalization	NN
cord-334133-61om170g	408	39	sequence	sequence	NN
cord-334133-61om170g	409	1	YXRF	YXRF	NNP
cord-334133-61om170g	409	2	implicates	implicate	VBZ
cord-334133-61om170g	409	3	a	a	DT
cord-334133-61om170g	409	4	tight	tight	JJ
cord-334133-61om170g	409	5	turn	turn	NN
cord-334133-61om170g	409	6	as	as	IN
cord-334133-61om170g	409	7	the	the	DT
cord-334133-61om170g	409	8	structural	structural	JJ
cord-334133-61om170g	409	9	recognition	recognition	NN
cord-334133-61om170g	409	10	motif	motif	NN
cord-334133-61om170g	409	11	for	for	IN
cord-334133-61om170g	409	12	endocytosis	endocytosis	NN
cord-334133-61om170g	409	13	A	a	DT
cord-334133-61om170g	409	14	synthetic	synthetic	JJ
cord-334133-61om170g	409	15	peptide	peptide	NN
cord-334133-61om170g	409	16	corresponding	correspond	VBG
cord-334133-61om170g	409	17	to	to	IN
cord-334133-61om170g	409	18	the	the	DT
cord-334133-61om170g	409	19	carboxyterminus	carboxyterminus	NNP
cord-334133-61om170g	409	20	of	of	IN
cord-334133-61om170g	409	21	human	human	JJ
cord-334133-61om170g	409	22	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	409	23	virus	virus	NN
cord-334133-61om170g	409	24	type	type	NN
cord-334133-61om170g	409	25	1	1	CD
cord-334133-61om170g	409	26	transmembrane	transmembrane	NN
cord-334133-61om170g	409	27	protein	protein	NN
cord-334133-61om170g	409	28	induces	induce	VBZ
cord-334133-61om170g	409	29	alterations	alteration	NNS
cord-334133-61om170g	409	30	in	in	IN
cord-334133-61om170g	409	31	the	the	DT
cord-334133-61om170g	409	32	ionic	ionic	JJ
cord-334133-61om170g	409	33	permeability	permeability	NN
cord-334133-61om170g	409	34	of	of	IN
cord-334133-61om170g	409	35	Xenopus	Xenopus	NNP
cord-334133-61om170g	409	36	laevis	laevi	NNS
cord-334133-61om170g	409	37	oocytes	oocyte	NNS
cord-334133-61om170g	410	1	Intracellular	intracellular	JJ
cord-334133-61om170g	410	2	degradation	degradation	NN
cord-334133-61om170g	410	3	of	of	IN
cord-334133-61om170g	410	4	the	the	DT
cord-334133-61om170g	410	5	HIV-1	HIV-1	NNP
cord-334133-61om170g	410	6	envelope	envelope	NN
cord-334133-61om170g	410	7	glycoprotein	glycoprotein	NN
cord-334133-61om170g	410	8	.	.	.
cord-334133-61om170g	411	1	Evidence	evidence	NN
cord-334133-61om170g	411	2	for	for	IN
cord-334133-61om170g	411	3	,	,	,
cord-334133-61om170g	411	4	and	and	CC
cord-334133-61om170g	411	5	some	some	DT
cord-334133-61om170g	411	6	characteristics	characteristic	NNS
cord-334133-61om170g	411	7	of	of	IN
cord-334133-61om170g	411	8	,	,	,
cord-334133-61om170g	411	9	an	an	DT
cord-334133-61om170g	411	10	endoplasmic	endoplasmic	NN
cord-334133-61om170g	411	11	reticulum	reticulum	NN
cord-334133-61om170g	411	12	pathway	pathway	NN
cord-334133-61om170g	411	13	Neutralization	neutralization	NN
cord-334133-61om170g	411	14	of	of	IN
cord-334133-61om170g	411	15	diverse	diverse	JJ
cord-334133-61om170g	411	16	strains	strain	NNS
cord-334133-61om170g	411	17	of	of	IN
cord-334133-61om170g	411	18	HIV-1	HIV-1	NNP
cord-334133-61om170g	411	19	by	by	IN
cord-334133-61om170g	411	20	monoclonal	monoclonal	JJ
cord-334133-61om170g	411	21	antibodies	antibody	NNS
cord-334133-61om170g	411	22	raised	raise	VBN
cord-334133-61om170g	411	23	against	against	IN
cord-334133-61om170g	411	24	a	a	DT
cord-334133-61om170g	411	25	gp41	gp41	NN
cord-334133-61om170g	411	26	synthetic	synthetic	JJ
cord-334133-61om170g	411	27	peptide	peptide	NN
cord-334133-61om170g	411	28	Deletion	deletion	NN
cord-334133-61om170g	411	29	of	of	IN
cord-334133-61om170g	411	30	a	a	DT
cord-334133-61om170g	411	31	single	single	JJ
cord-334133-61om170g	411	32	N	n	CD
cord-334133-61om170g	411	33	-	-	HYPH
cord-334133-61om170g	411	34	linked	link	VBN
cord-334133-61om170g	411	35	site	site	NN
cord-334133-61om170g	411	36	from	from	IN
cord-334133-61om170g	411	37	the	the	DT
cord-334133-61om170g	411	38	transmembrane	transmembrane	NNP
cord-334133-61om170g	411	39	envelope	envelope	NN
cord-334133-61om170g	411	40	protein	protein	NN
cord-334133-61om170g	411	41	of	of	IN
cord-334133-61om170g	411	42	human	human	JJ
cord-334133-61om170g	411	43	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	44	virus	virus	NN
cord-334133-61om170g	411	45	type	type	NN
cord-334133-61om170g	411	46	1	1	CD
cord-334133-61om170g	411	47	stops	stop	VBZ
cord-334133-61om170g	411	48	cleavage	cleavage	NN
cord-334133-61om170g	411	49	and	and	CC
cord-334133-61om170g	411	50	transport	transport	NN
cord-334133-61om170g	411	51	of	of	IN
cord-334133-61om170g	411	52	gp160	gp160	NNP
cord-334133-61om170g	411	53	preventing	prevent	VBG
cord-334133-61om170g	411	54	Env	Env	NNP
cord-334133-61om170g	411	55	-	-	HYPH
cord-334133-61om170g	411	56	mediated	mediate	VBN
cord-334133-61om170g	411	57	fusion	fusion	NN
cord-334133-61om170g	411	58	Polarized	polarized	JJ
cord-334133-61om170g	411	59	human	human	JJ
cord-334133-61om170g	411	60	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	61	virus	virus	NN
cord-334133-61om170g	411	62	budded	bud	VBN
cord-334133-61om170g	411	63	in	in	IN
cord-334133-61om170g	411	64	lymphocytes	lymphocyte	NNS
cord-334133-61om170g	411	65	involves	involve	VBZ
cord-334133-61om170g	411	66	a	a	DT
cord-334133-61om170g	411	67	tyrosine	tyrosine	NN
cord-334133-61om170g	411	68	-	-	HYPH
cord-334133-61om170g	411	69	based	base	VBN
cord-334133-61om170g	411	70	signal	signal	NN
cord-334133-61om170g	411	71	and	and	CC
cord-334133-61om170g	411	72	favors	favor	VBZ
cord-334133-61om170g	411	73	cellto	cellto	NN
cord-334133-61om170g	411	74	-	-	HYPH
cord-334133-61om170g	411	75	cell	cell	NN
cord-334133-61om170g	411	76	viral	viral	JJ
cord-334133-61om170g	411	77	transmission	transmission	NN
cord-334133-61om170g	411	78	Characterization	characterization	NN
cord-334133-61om170g	411	79	of	of	IN
cord-334133-61om170g	411	80	the	the	DT
cord-334133-61om170g	411	81	biosynthesis	biosynthesis	NN
cord-334133-61om170g	411	82	of	of	IN
cord-334133-61om170g	411	83	human	human	JJ
cord-334133-61om170g	411	84	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	85	virus	virus	NN
cord-334133-61om170g	411	86	type	type	NN
cord-334133-61om170g	411	87	1	1	CD
cord-334133-61om170g	411	88	Env	Env	NNP
cord-334133-61om170g	411	89	from	from	IN
cord-334133-61om170g	411	90	infected	infected	JJ
cord-334133-61om170g	411	91	T	t	NN
cord-334133-61om170g	411	92	-	-	HYPH
cord-334133-61om170g	411	93	cells	cell	NNS
cord-334133-61om170g	411	94	and	and	CC
cord-334133-61om170g	411	95	the	the	DT
cord-334133-61om170g	411	96	effects	effect	NNS
cord-334133-61om170g	411	97	of	of	IN
cord-334133-61om170g	411	98	glucose	glucose	NN
cord-334133-61om170g	411	99	trimming	trimming	NN
cord-334133-61om170g	411	100	of	of	IN
cord-334133-61om170g	411	101	Env	Env	NNP
cord-334133-61om170g	411	102	on	on	IN
cord-334133-61om170g	411	103	virion	virion	NN
cord-334133-61om170g	411	104	infectivity	infectivity	NN
cord-334133-61om170g	411	105	Biosynthesis	Biosynthesis	NNP
cord-334133-61om170g	411	106	and	and	CC
cord-334133-61om170g	411	107	processing	processing	NN
cord-334133-61om170g	411	108	of	of	IN
cord-334133-61om170g	411	109	human	human	JJ
cord-334133-61om170g	411	110	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	111	virus	virus	NN
cord-334133-61om170g	411	112	type	type	NN
cord-334133-61om170g	411	113	1	1	CD
cord-334133-61om170g	411	114	envelope	envelope	NN
cord-334133-61om170g	411	115	glycoproteins	glycoprotein	NNS
cord-334133-61om170g	411	116	:	:	:
cord-334133-61om170g	411	117	effects	effect	NNS
cord-334133-61om170g	411	118	of	of	IN
cord-334133-61om170g	411	119	monensin	monensin	NNP
cord-334133-61om170g	411	120	on	on	IN
cord-334133-61om170g	411	121	glycosylation	glycosylation	NN
cord-334133-61om170g	411	122	and	and	CC
cord-334133-61om170g	411	123	transport	transport	NN
cord-334133-61om170g	411	124	Processing	processing	NN
cord-334133-61om170g	411	125	of	of	IN
cord-334133-61om170g	411	126	the	the	DT
cord-334133-61om170g	411	127	envelope	envelope	NN
cord-334133-61om170g	411	128	protein	protein	NN
cord-334133-61om170g	411	129	gp160	gp160	NN
cord-334133-61om170g	411	130	in	in	IN
cord-334133-61om170g	411	131	immunotoxin	immunotoxin	NN
cord-334133-61om170g	411	132	-	-	HYPH
cord-334133-61om170g	411	133	resistant	resistant	JJ
cord-334133-61om170g	411	134	cell	cell	NN
cord-334133-61om170g	411	135	lines	line	NNS
cord-334133-61om170g	411	136	chronically	chronically	RB
cord-334133-61om170g	411	137	infected	infect	VBN
cord-334133-61om170g	411	138	with	with	IN
cord-334133-61om170g	411	139	human	human	JJ
cord-334133-61om170g	411	140	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	141	virus	virus	NN
cord-334133-61om170g	411	142	type	type	NN
cord-334133-61om170g	411	143	1	1	CD
cord-334133-61om170g	411	144	Intranasal	Intranasal	NNP
cord-334133-61om170g	411	145	immunization	immunization	NN
cord-334133-61om170g	411	146	with	with	IN
cord-334133-61om170g	411	147	a	a	DT
cord-334133-61om170g	411	148	plant	plant	NN
cord-334133-61om170g	411	149	virus	virus	NN
cord-334133-61om170g	411	150	expressing	express	VBG
cord-334133-61om170g	411	151	a	a	DT
cord-334133-61om170g	411	152	peptide	peptide	NN
cord-334133-61om170g	411	153	from	from	IN
cord-334133-61om170g	411	154	HIV-1	HIV-1	NNP
cord-334133-61om170g	411	155	gp41	gp41	NNP
cord-334133-61om170g	411	156	stimulates	stimulate	VBZ
cord-334133-61om170g	411	157	better	well	JJR
cord-334133-61om170g	411	158	mucosal	mucosal	JJ
cord-334133-61om170g	411	159	and	and	CC
cord-334133-61om170g	411	160	systemic	systemic	JJ
cord-334133-61om170g	411	161	HIV-1-specific	HIV-1-specific	NNP
cord-334133-61om170g	411	162	IgA	IgA	NNP
cord-334133-61om170g	411	163	and	and	CC
cord-334133-61om170g	411	164	IgG	IgG	NNP
cord-334133-61om170g	411	165	than	than	IN
cord-334133-61om170g	411	166	oral	oral	JJ
cord-334133-61om170g	411	167	immunization	immunization	NN
cord-334133-61om170g	411	168	Folding	folding	NN
cord-334133-61om170g	411	169	,	,	,
cord-334133-61om170g	411	170	interaction	interaction	NN
cord-334133-61om170g	411	171	with	with	IN
cord-334133-61om170g	411	172	GRP78-BiP	GRP78-BiP	NNP
cord-334133-61om170g	411	173	,	,	,
cord-334133-61om170g	411	174	assembly	assembly	NN
cord-334133-61om170g	411	175	,	,	,
cord-334133-61om170g	411	176	and	and	CC
cord-334133-61om170g	411	177	transport	transport	NN
cord-334133-61om170g	411	178	of	of	IN
cord-334133-61om170g	411	179	the	the	DT
cord-334133-61om170g	411	180	human	human	JJ
cord-334133-61om170g	411	181	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	182	virus	virus	NN
cord-334133-61om170g	411	183	type	type	NN
cord-334133-61om170g	411	184	1	1	CD
cord-334133-61om170g	411	185	envelope	envelope	NN
cord-334133-61om170g	411	186	protein	protein	NN
cord-334133-61om170g	411	187	Human	human	JJ
cord-334133-61om170g	411	188	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	411	189	virus	virus	NN
cord-334133-61om170g	411	190	type	type	NN
cord-334133-61om170g	411	191	1	1	CD
cord-334133-61om170g	411	192	envelope	envelope	NN
cord-334133-61om170g	411	193	protein	protein	NN
cord-334133-61om170g	411	194	endocytosis	endocytosis	NN
cord-334133-61om170g	411	195	mediated	mediate	VBN
cord-334133-61om170g	411	196	by	by	IN
cord-334133-61om170g	411	197	a	a	DT
cord-334133-61om170g	411	198	highly	highly	RB
cord-334133-61om170g	411	199	conserved	conserve	VBN
cord-334133-61om170g	411	200	intrinsic	intrinsic	JJ
cord-334133-61om170g	411	201	internalization	internalization	NN
cord-334133-61om170g	411	202	signal	signal	NN
cord-334133-61om170g	411	203	in	in	IN
cord-334133-61om170g	411	204	the	the	DT
cord-334133-61om170g	411	205	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	411	206	domain	domain	NN
cord-334133-61om170g	411	207	of	of	IN
cord-334133-61om170g	411	208	gp41	gp41	NNP
cord-334133-61om170g	411	209	is	be	VBZ
cord-334133-61om170g	411	210	suppressed	suppress	VBN
cord-334133-61om170g	411	211	in	in	IN
cord-334133-61om170g	411	212	the	the	DT
cord-334133-61om170g	411	213	presence	presence	NN
cord-334133-61om170g	411	214	of	of	IN
cord-334133-61om170g	411	215	the	the	DT
cord-334133-61om170g	411	216	Pr55gag	Pr55gag	NNP
cord-334133-61om170g	411	217	precursor	precursor	NN
cord-334133-61om170g	411	218	Analysis	Analysis	NNP
cord-334133-61om170g	411	219	of	of	IN
cord-334133-61om170g	411	220	membrane	membrane	NN
cord-334133-61om170g	411	221	and	and	CC
cord-334133-61om170g	411	222	surface	surface	NN
cord-334133-61om170g	411	223	protein	protein	NN
cord-334133-61om170g	411	224	sequences	sequence	NNS
cord-334133-61om170g	411	225	with	with	IN
cord-334133-61om170g	411	226	the	the	DT
cord-334133-61om170g	411	227	hydrophobic	hydrophobic	JJ
cord-334133-61om170g	411	228	moment	moment	NN
cord-334133-61om170g	411	229	plot	plot	NN
cord-334133-61om170g	411	230	An	an	DT
cord-334133-61om170g	411	231	engineered	engineer	VBN
cord-334133-61om170g	411	232	poliovirus	poliovirus	NN
cord-334133-61om170g	411	233	chimaera	chimaera	NN
cord-334133-61om170g	411	234	elicits	elicit	VBZ
cord-334133-61om170g	411	235	broadly	broadly	RB
cord-334133-61om170g	411	236	reactive	reactive	JJ
cord-334133-61om170g	411	237	HIV-1	HIV-1	NNP
cord-334133-61om170g	411	238	neutralizing	neutralize	VBG
cord-334133-61om170g	411	239	antibodies	antibody	NNS
cord-334133-61om170g	411	240	Nucleotide	nucleotide	JJ
cord-334133-61om170g	411	241	sequence	sequence	NN
cord-334133-61om170g	411	242	of	of	IN
cord-334133-61om170g	411	243	an	an	DT
cord-334133-61om170g	411	244	mRNA	mrna	NN
cord-334133-61om170g	411	245	transcribed	transcribe	VBN
cord-334133-61om170g	411	246	in	in	IN
cord-334133-61om170g	411	247	latent	latent	JJ
cord-334133-61om170g	411	248	growth	growth	NN
cord-334133-61om170g	411	249	-	-	HYPH
cord-334133-61om170g	411	250	transforming	transform	VBG
cord-334133-61om170g	411	251	virus	virus	NN
cord-334133-61om170g	411	252	infection	infection	NN
cord-334133-61om170g	411	253	indicates	indicate	VBZ
cord-334133-61om170g	411	254	that	that	IN
cord-334133-61om170g	411	255	it	-PRON-	PRP
cord-334133-61om170g	411	256	may	may	MD
cord-334133-61om170g	411	257	encode	encode	VB
cord-334133-61om170g	411	258	a	a	DT
cord-334133-61om170g	411	259	membrane	membrane	NN
cord-334133-61om170g	411	260	protein	protein	NN
cord-334133-61om170g	412	1	The	the	DT
cord-334133-61om170g	412	2	glycosylation	glycosylation	NN
cord-334133-61om170g	412	3	of	of	IN
cord-334133-61om170g	412	4	human	human	JJ
cord-334133-61om170g	412	5	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	412	6	virus	virus	NN
cord-334133-61om170g	412	7	type	type	NN
cord-334133-61om170g	412	8	1	1	CD
cord-334133-61om170g	412	9	transmembrane	transmembrane	NN
cord-334133-61om170g	412	10	protein	protein	NN
cord-334133-61om170g	412	11	(	(	-LRB-
cord-334133-61om170g	412	12	gp41	gp41	NNP
cord-334133-61om170g	412	13	)	)	-RRB-
cord-334133-61om170g	412	14	is	be	VBZ
cord-334133-61om170g	412	15	important	important	JJ
cord-334133-61om170g	412	16	for	for	IN
cord-334133-61om170g	412	17	the	the	DT
cord-334133-61om170g	412	18	efficient	efficient	JJ
cord-334133-61om170g	412	19	transport	transport	NN
cord-334133-61om170g	412	20	of	of	IN
cord-334133-61om170g	412	21	the	the	DT
cord-334133-61om170g	412	22	envelope	envelope	NN
cord-334133-61om170g	412	23	precursor	precursor	NN
cord-334133-61om170g	412	24	gp160	gp160	NNP
cord-334133-61om170g	412	25	Detection	Detection	NNP
cord-334133-61om170g	412	26	of	of	IN
cord-334133-61om170g	412	27	fusion	fusion	NN
cord-334133-61om170g	412	28	peptide	peptide	NN
cord-334133-61om170g	412	29	sequence	sequence	NN
cord-334133-61om170g	412	30	in	in	IN
cord-334133-61om170g	412	31	the	the	DT
cord-334133-61om170g	412	32	transmembrane	transmembrane	NNP
cord-334133-61om170g	412	33	peptide	peptide	NN
cord-334133-61om170g	412	34	of	of	IN
cord-334133-61om170g	412	35	human	human	JJ
cord-334133-61om170g	412	36	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	412	37	virus	virus	NN
cord-334133-61om170g	413	1	A	a	DT
cord-334133-61om170g	413	2	general	general	JJ
cord-334133-61om170g	413	3	model	model	NN
cord-334133-61om170g	413	4	for	for	IN
cord-334133-61om170g	413	5	the	the	DT
cord-334133-61om170g	413	6	transmembrane	transmembrane	NN
cord-334133-61om170g	413	7	proteins	protein	NNS
cord-334133-61om170g	413	8	of	of	IN
cord-334133-61om170g	413	9	HIV	HIV	NNP
cord-334133-61om170g	413	10	and	and	CC
cord-334133-61om170g	413	11	other	other	JJ
cord-334133-61om170g	413	12	retroviruses	retrovirus	NNS
cord-334133-61om170g	413	13	Interaction	Interaction	NNP
cord-334133-61om170g	413	14	of	of	IN
cord-334133-61om170g	413	15	peptide	peptide	NN
cord-334133-61om170g	413	16	fragment	fragment	NN
cord-334133-61om170g	414	1	828	828	CD
cord-334133-61om170g	415	1	-848	-848	NN
cord-334133-61om170g	415	2	of	of	IN
cord-334133-61om170g	415	3	the	the	DT
cord-334133-61om170g	415	4	envelope	envelope	NN
cord-334133-61om170g	415	5	glycoprotein	glycoprotein	NN
cord-334133-61om170g	415	6	of	of	IN
cord-334133-61om170g	415	7	human	human	JJ
cord-334133-61om170g	415	8	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	415	9	virus	virus	NN
cord-334133-61om170g	415	10	type	type	NN
cord-334133-61om170g	415	11	1	1	CD
cord-334133-61om170g	415	12	with	with	IN
cord-334133-61om170g	415	13	lipid	lipid	NN
cord-334133-61om170g	415	14	bilayers	bilayer	NNS
cord-334133-61om170g	415	15	Sequence	sequence	NN
cord-334133-61om170g	415	16	similarities	similarity	NNS
cord-334133-61om170g	415	17	between	between	IN
cord-334133-61om170g	415	18	human	human	JJ
cord-334133-61om170g	415	19	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	415	20	virus	virus	NN
cord-334133-61om170g	415	21	gp41	gp41	NNP
cord-334133-61om170g	415	22	and	and	CC
cord-334133-61om170g	415	23	paramyxovirus	paramyxovirus	JJ
cord-334133-61om170g	415	24	fusion	fusion	NN
cord-334133-61om170g	415	25	proteins	protein	VBZ
cord-334133-61om170g	415	26	Secretion	secretion	NN
cord-334133-61om170g	415	27	of	of	IN
cord-334133-61om170g	415	28	a	a	DT
cord-334133-61om170g	415	29	truncated	truncated	JJ
cord-334133-61om170g	415	30	form	form	NN
cord-334133-61om170g	415	31	of	of	IN
cord-334133-61om170g	415	32	the	the	DT
cord-334133-61om170g	415	33	human	human	JJ
cord-334133-61om170g	415	34	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	415	35	virus	virus	NN
cord-334133-61om170g	415	36	type	type	NN
cord-334133-61om170g	415	37	1	1	CD
cord-334133-61om170g	415	38	envelope	envelope	NN
cord-334133-61om170g	415	39	glycoprotein	glycoprotein	VBG
cord-334133-61om170g	415	40	An	an	DT
cord-334133-61om170g	415	41	antibody	antibody	NN
cord-334133-61om170g	415	42	specific	specific	JJ
cord-334133-61om170g	415	43	for	for	IN
cord-334133-61om170g	415	44	the	the	DT
cord-334133-61om170g	415	45	C	C	NNP
cord-334133-61om170g	415	46	-	-	HYPH
cord-334133-61om170g	415	47	terminal	terminal	NN
cord-334133-61om170g	415	48	tail	tail	NN
cord-334133-61om170g	415	49	of	of	IN
cord-334133-61om170g	415	50	gp41	gp41	NNP
cord-334133-61om170g	415	51	of	of	IN
cord-334133-61om170g	415	52	HIV-1	HIV-1	NNP
cord-334133-61om170g	416	1	mediates	mediate	VBZ
cord-334133-61om170g	416	2	post	post	JJ
cord-334133-61om170g	416	3	-	-	JJ
cord-334133-61om170g	416	4	attachment	attachment	JJ
cord-334133-61om170g	416	5	neutralization	neutralization	NN
cord-334133-61om170g	416	6	probably	probably	RB
cord-334133-61om170g	416	7	through	through	IN
cord-334133-61om170g	416	8	inhibiting	inhibit	VBG
cord-334133-61om170g	416	9	virus	virus	NN
cord-334133-61om170g	416	10	-	-	HYPH
cord-334133-61om170g	416	11	cell	cell	NN
cord-334133-61om170g	416	12	fusion	fusion	NN
cord-334133-61om170g	416	13	Recognition	recognition	NN
cord-334133-61om170g	416	14	of	of	IN
cord-334133-61om170g	416	15	sorting	sort	VBG
cord-334133-61om170g	416	16	signals	signal	NNS
cord-334133-61om170g	416	17	by	by	IN
cord-334133-61om170g	416	18	clathrin	clathrin	NN
cord-334133-61om170g	416	19	adapters	adapter	NNS
cord-334133-61om170g	417	1	A	a	DT
cord-334133-61om170g	417	2	membrane	membrane	NN
cord-334133-61om170g	417	3	protein	protein	NN
cord-334133-61om170g	417	4	encoded	encode	VBN
cord-334133-61om170g	417	5	by	by	IN
cord-334133-61om170g	417	6	Epstein	Epstein	NNP
cord-334133-61om170g	417	7	-Barr	-Barr	NNP
cord-334133-61om170g	417	8	virus	virus	NN
cord-334133-61om170g	417	9	in	in	IN
cord-334133-61om170g	417	10	latent	latent	JJ
cord-334133-61om170g	417	11	growthtransforming	growthtransforming	NN
cord-334133-61om170g	417	12	infection	infection	NN
cord-334133-61om170g	417	13	Human	human	JJ
cord-334133-61om170g	417	14	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	417	15	virus	virus	NN
cord-334133-61om170g	417	16	virus	virus	NN
cord-334133-61om170g	417	17	-	-	:
cord-334133-61om170g	417	18	neutralizing	neutralize	VBG
cord-334133-61om170g	417	19	antibodies	antibody	NNS
cord-334133-61om170g	417	20	recognise	recognise	VBP
cord-334133-61om170g	417	21	several	several	JJ
cord-334133-61om170g	417	22	conserved	conserve	VBN
cord-334133-61om170g	417	23	domains	domain	NNS
cord-334133-61om170g	417	24	on	on	IN
cord-334133-61om170g	417	25	the	the	DT
cord-334133-61om170g	417	26	envelope	envelope	NN
cord-334133-61om170g	417	27	glycoprotein	glycoprotein	NN
cord-334133-61om170g	417	28	The	the	DT
cord-334133-61om170g	417	29	tyrosinebased	tyrosinebased	JJ
cord-334133-61om170g	417	30	lysosomal	lysosomal	NN
cord-334133-61om170g	417	31	targeting	target	VBG
cord-334133-61om170g	417	32	signal	signal	NN
cord-334133-61om170g	417	33	in	in	IN
cord-334133-61om170g	417	34	lamp-1	lamp-1	NNP
cord-334133-61om170g	417	35	mediates	mediate	VBZ
cord-334133-61om170g	417	36	sorting	sort	VBG
cord-334133-61om170g	417	37	into	into	IN
cord-334133-61om170g	417	38	Golgiderived	Golgiderived	NNP
cord-334133-61om170g	417	39	clathrin	clathrin	NN
cord-334133-61om170g	417	40	-	-	HYPH
cord-334133-61om170g	417	41	coated	coat	VBN
cord-334133-61om170g	417	42	vesicles	vesicle	NNS
cord-334133-61om170g	417	43	Prediction	Prediction	NNP
cord-334133-61om170g	417	44	of	of	IN
cord-334133-61om170g	417	45	protein	protein	NN
cord-334133-61om170g	417	46	antigenic	antigenic	JJ
cord-334133-61om170g	417	47	determinants	determinant	NNS
cord-334133-61om170g	417	48	from	from	IN
cord-334133-61om170g	417	49	amino	amino	NN
cord-334133-61om170g	417	50	acid	acid	NN
cord-334133-61om170g	417	51	sequences	sequence	NNS
cord-334133-61om170g	418	1	Intracellular	intracellular	JJ
cord-334133-61om170g	418	2	interaction	interaction	NN
cord-334133-61om170g	418	3	of	of	IN
cord-334133-61om170g	418	4	human	human	JJ
cord-334133-61om170g	418	5	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	418	6	virus	virus	NN
cord-334133-61om170g	418	7	type	type	NN
cord-334133-61om170g	418	8	(	(	-LRB-
cord-334133-61om170g	418	9	ARV-2	ARV-2	NNP
cord-334133-61om170g	418	10	)	)	-RRB-
cord-334133-61om170g	418	11	envelope	envelope	NN
cord-334133-61om170g	418	12	glycoprotein	glycoprotein	NN
cord-334133-61om170g	418	13	gp160	gp160	NNP
cord-334133-61om170g	418	14	with	with	IN
cord-334133-61om170g	418	15	CD4	CD4	NNP
cord-334133-61om170g	418	16	blocks	block	VBZ
cord-334133-61om170g	418	17	the	the	DT
cord-334133-61om170g	418	18	movement	movement	NN
cord-334133-61om170g	418	19	and	and	CC
cord-334133-61om170g	418	20	maturation	maturation	NN
cord-334133-61om170g	418	21	of	of	IN
cord-334133-61om170g	418	22	CD4	CD4	NNP
cord-334133-61om170g	418	23	to	to	IN
cord-334133-61om170g	418	24	the	the	DT
cord-334133-61om170g	418	25	plasma	plasma	NN
cord-334133-61om170g	418	26	membrane	membrane	NN
cord-334133-61om170g	418	27	Structure	structure	NN
cord-334133-61om170g	418	28	predictions	prediction	NNS
cord-334133-61om170g	418	29	of	of	IN
cord-334133-61om170g	418	30	membrane	membrane	NN
cord-334133-61om170g	418	31	proteins	protein	NNS
cord-334133-61om170g	419	1	are	be	VBP
cord-334133-61om170g	419	2	not	not	RB
cord-334133-61om170g	419	3	that	that	RB
cord-334133-61om170g	419	4	bad	bad	JJ
cord-334133-61om170g	419	5	Surface	surface	NN
cord-334133-61om170g	419	6	and	and	CC
cord-334133-61om170g	419	7	inside	inside	JJ
cord-334133-61om170g	419	8	volumes	volume	NNS
cord-334133-61om170g	419	9	in	in	IN
cord-334133-61om170g	419	10	globular	globular	JJ
cord-334133-61om170g	419	11	proteins	protein	NNS
cord-334133-61om170g	420	1	Megalomycin	Megalomycin	NNP
cord-334133-61om170g	420	2	inhibits	inhibit	VBZ
cord-334133-61om170g	420	3	HIV-1	HIV-1	NNP
cord-334133-61om170g	420	4	replication	replication	NN
cord-334133-61om170g	420	5	and	and	CC
cord-334133-61om170g	420	6	interferes	interfere	VBZ
cord-334133-61om170g	420	7	with	with	IN
cord-334133-61om170g	420	8	gp160	gp160	NNP
cord-334133-61om170g	420	9	processing	processing	NN
cord-334133-61om170g	420	10	Endoproteolytic	endoproteolytic	JJ
cord-334133-61om170g	420	11	cleavage	cleavage	NN
cord-334133-61om170g	420	12	of	of	IN
cord-334133-61om170g	420	13	HIV-1	HIV-1	NNP
cord-334133-61om170g	420	14	gp160	gp160	NNP
cord-334133-61om170g	420	15	envelope	envelope	NN
cord-334133-61om170g	420	16	precursor	precursor	NN
cord-334133-61om170g	420	17	occurs	occur	VBZ
cord-334133-61om170g	420	18	after	after	IN
cord-334133-61om170g	420	19	exit	exit	NN
cord-334133-61om170g	420	20	from	from	IN
cord-334133-61om170g	420	21	the	the	DT
cord-334133-61om170g	420	22	trans	trans	NNP
cord-334133-61om170g	420	23	-	-	NNP
cord-334133-61om170g	420	24	Golgi	Golgi	NNP
cord-334133-61om170g	420	25	network	network	NN
cord-334133-61om170g	420	26	(	(	-LRB-
cord-334133-61om170g	420	27	TGN	TGN	NNP
cord-334133-61om170g	420	28	)	)	-RRB-
cord-334133-61om170g	420	29	Antiserum	Antiserum	NNP
cord-334133-61om170g	420	30	to	to	IN
cord-334133-61om170g	420	31	a	a	DT
cord-334133-61om170g	420	32	synthetic	synthetic	JJ
cord-334133-61om170g	420	33	peptide	peptide	NN
cord-334133-61om170g	420	34	recognizes	recognize	VBZ
cord-334133-61om170g	420	35	the	the	DT
cord-334133-61om170g	420	36	HTLV	HTLV	NNP
cord-334133-61om170g	420	37	-	-	HYPH
cord-334133-61om170g	420	38	III	III	NNP
cord-334133-61om170g	420	39	envelope	envelope	NN
cord-334133-61om170g	420	40	glycoprotein	glycoprotein	NN
cord-334133-61om170g	420	41	Uncleaved	uncleave	VBN
cord-334133-61om170g	421	1	env	env	NNP
cord-334133-61om170g	421	2	gp160	gp160	NNP
cord-334133-61om170g	421	3	of	of	IN
cord-334133-61om170g	421	4	human	human	JJ
cord-334133-61om170g	421	5	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	421	6	virus	virus	NN
cord-334133-61om170g	421	7	type	type	NN
cord-334133-61om170g	421	8	1	1	CD
cord-334133-61om170g	421	9	is	be	VBZ
cord-334133-61om170g	421	10	degraded	degrade	VBN
cord-334133-61om170g	421	11	within	within	IN
cord-334133-61om170g	421	12	the	the	DT
cord-334133-61om170g	421	13	Golgi	Golgi	NNP
cord-334133-61om170g	421	14	apparatus	apparatus	NN
cord-334133-61om170g	421	15	but	but	CC
cord-334133-61om170g	421	16	not	not	RB
cord-334133-61om170g	421	17	lysosomes	lysosome	VBZ
cord-334133-61om170g	421	18	in	in	IN
cord-334133-61om170g	421	19	COS-1	COS-1	NNP
cord-334133-61om170g	421	20	cells	cell	NNS
cord-334133-61om170g	421	21	Glycosylation	Glycosylation	NNP
cord-334133-61om170g	421	22	and	and	CC
cord-334133-61om170g	421	23	processing	processing	NN
cord-334133-61om170g	421	24	of	of	IN
cord-334133-61om170g	421	25	the	the	DT
cord-334133-61om170g	421	26	human	human	JJ
cord-334133-61om170g	421	27	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	421	28	virus	virus	NN
cord-334133-61om170g	421	29	type	type	NN
cord-334133-61om170g	421	30	1	1	CD
cord-334133-61om170g	421	31	envelope	envelope	NN
cord-334133-61om170g	421	32	glycoprotein	glycoprotein	VBG
cord-334133-61om170g	421	33	A	a	DT
cord-334133-61om170g	421	34	simple	simple	JJ
cord-334133-61om170g	421	35	method	method	NN
cord-334133-61om170g	421	36	for	for	IN
cord-334133-61om170g	421	37	displaying	display	VBG
cord-334133-61om170g	421	38	the	the	DT
cord-334133-61om170g	421	39	hydropathic	hydropathic	JJ
cord-334133-61om170g	421	40	character	character	NN
cord-334133-61om170g	421	41	of	of	IN
cord-334133-61om170g	421	42	a	a	DT
cord-334133-61om170g	421	43	protein	protein	NN
cord-334133-61om170g	421	44	HIV	HIV	NNP
cord-334133-61om170g	421	45	and	and	CC
cord-334133-61om170g	421	46	the	the	DT
cord-334133-61om170g	421	47	Pathogenesis	Pathogenesis	NNP
cord-334133-61om170g	421	48	of	of	IN
cord-334133-61om170g	421	49	AIDS	AIDS	NNP
cord-334133-61om170g	421	50	Antiparallel	Antiparallel	NNP
cord-334133-61om170g	421	51	and	and	CC
cord-334133-61om170g	421	52	parallel	parallel	JJ
cord-334133-61om170g	421	53	beta	beta	NN
cord-334133-61om170g	421	54	-	-	HYPH
cord-334133-61om170g	421	55	strands	strand	NNS
cord-334133-61om170g	421	56	differ	differ	VBP
cord-334133-61om170g	421	57	in	in	IN
cord-334133-61om170g	421	58	amino	amino	NN
cord-334133-61om170g	421	59	acid	acid	NN
cord-334133-61om170g	421	60	residue	residue	NN
cord-334133-61om170g	421	61	preferences	preference	NNS
cord-334133-61om170g	422	1	The	the	DT
cord-334133-61om170g	422	2	membraneproximal	membraneproximal	FW
cord-334133-61om170g	422	3	intracytoplasmic	intracytoplasmic	NNP
cord-334133-61om170g	422	4	tyrosine	tyrosine	NN
cord-334133-61om170g	422	5	residue	residue	NN
cord-334133-61om170g	422	6	of	of	IN
cord-334133-61om170g	422	7	HIV-1	HIV-1	NNP
cord-334133-61om170g	422	8	envelope	envelope	NN
cord-334133-61om170g	422	9	glycoprotein	glycoprotein	NN
cord-334133-61om170g	422	10	is	be	VBZ
cord-334133-61om170g	422	11	critical	critical	JJ
cord-334133-61om170g	422	12	for	for	IN
cord-334133-61om170g	422	13	basolateral	basolateral	JJ
cord-334133-61om170g	422	14	targeting	targeting	NN
cord-334133-61om170g	422	15	of	of	IN
cord-334133-61om170g	422	16	viral	viral	JJ
cord-334133-61om170g	422	17	budding	budding	NN
cord-334133-61om170g	422	18	in	in	IN
cord-334133-61om170g	422	19	MDCK	MDCK	NNP
cord-334133-61om170g	422	20	cells	cell	NNS
cord-334133-61om170g	422	21	Analysis	Analysis	NNP
cord-334133-61om170g	422	22	of	of	IN
cord-334133-61om170g	422	23	the	the	DT
cord-334133-61om170g	422	24	ability	ability	NN
cord-334133-61om170g	422	25	of	of	IN
cord-334133-61om170g	422	26	five	five	CD
cord-334133-61om170g	422	27	adjuvants	adjuvant	NNS
cord-334133-61om170g	422	28	to	to	TO
cord-334133-61om170g	422	29	enhance	enhance	VB
cord-334133-61om170g	422	30	immune	immune	JJ
cord-334133-61om170g	422	31	responses	response	NNS
cord-334133-61om170g	422	32	to	to	IN
cord-334133-61om170g	422	33	a	a	DT
cord-334133-61om170g	422	34	chimeric	chimeric	JJ
cord-334133-61om170g	422	35	plant	plant	NN
cord-334133-61om170g	422	36	virus	virus	NN
cord-334133-61om170g	422	37	displaying	display	VBG
cord-334133-61om170g	422	38	a	a	DT
cord-334133-61om170g	422	39	HIV-1	HIV-1	NNP
cord-334133-61om170g	422	40	peptide	peptide	NN
cord-334133-61om170g	422	41	Human	human	JJ
cord-334133-61om170g	422	42	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	43	virus	virus	NN
cord-334133-61om170g	422	44	type	type	NN
cord-334133-61om170g	422	45	1	1	CD
cord-334133-61om170g	422	46	neutralizing	neutralize	VBG
cord-334133-61om170g	422	47	antibodies	antibody	NNS
cord-334133-61om170g	422	48	raised	raise	VBN
cord-334133-61om170g	422	49	to	to	IN
cord-334133-61om170g	422	50	a	a	DT
cord-334133-61om170g	422	51	gp41	gp41	NN
cord-334133-61om170g	422	52	peptide	peptide	NN
cord-334133-61om170g	422	53	expressed	express	VBN
cord-334133-61om170g	422	54	on	on	IN
cord-334133-61om170g	422	55	the	the	DT
cord-334133-61om170g	422	56	surface	surface	NN
cord-334133-61om170g	422	57	of	of	IN
cord-334133-61om170g	422	58	a	a	DT
cord-334133-61om170g	422	59	plant	plant	NN
cord-334133-61om170g	422	60	virus	virus	NN
cord-334133-61om170g	422	61	Stimulation	stimulation	NN
cord-334133-61om170g	422	62	of	of	IN
cord-334133-61om170g	422	63	neutralizing	neutralize	VBG
cord-334133-61om170g	422	64	antibodies	antibody	NNS
cord-334133-61om170g	422	65	to	to	IN
cord-334133-61om170g	422	66	human	human	JJ
cord-334133-61om170g	422	67	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	68	virus	virus	NN
cord-334133-61om170g	422	69	type	type	NN
cord-334133-61om170g	422	70	1	1	CD
cord-334133-61om170g	422	71	in	in	IN
cord-334133-61om170g	422	72	three	three	CD
cord-334133-61om170g	422	73	strains	strain	NNS
cord-334133-61om170g	422	74	of	of	IN
cord-334133-61om170g	422	75	mice	mouse	NNS
cord-334133-61om170g	422	76	immunized	immunize	VBN
cord-334133-61om170g	422	77	with	with	IN
cord-334133-61om170g	422	78	a	a	DT
cord-334133-61om170g	422	79	22-mer	22-mer	CD
cord-334133-61om170g	422	80	amino	amino	NN
cord-334133-61om170g	422	81	acid	acid	NN
cord-334133-61om170g	422	82	peptide	peptide	NN
cord-334133-61om170g	422	83	expressed	express	VBD
cord-334133-61om170g	422	84	on	on	IN
cord-334133-61om170g	422	85	the	the	DT
cord-334133-61om170g	422	86	surface	surface	NN
cord-334133-61om170g	422	87	of	of	IN
cord-334133-61om170g	422	88	a	a	DT
cord-334133-61om170g	422	89	plant	plant	NN
cord-334133-61om170g	422	90	virus	virus	NN
cord-334133-61om170g	422	91	Different	different	JJ
cord-334133-61om170g	422	92	effects	effect	NNS
cord-334133-61om170g	422	93	of	of	IN
cord-334133-61om170g	422	94	a	a	DT
cord-334133-61om170g	422	95	single	single	JJ
cord-334133-61om170g	422	96	amino	amino	NN
cord-334133-61om170g	422	97	acid	acid	NN
cord-334133-61om170g	422	98	substitution	substitution	NN
cord-334133-61om170g	422	99	on	on	IN
cord-334133-61om170g	422	100	three	three	CD
cord-334133-61om170g	422	101	epitopes	epitope	NNS
cord-334133-61om170g	422	102	in	in	IN
cord-334133-61om170g	422	103	the	the	DT
cord-334133-61om170g	422	104	gp41	gp41	NNP
cord-334133-61om170g	422	105	C	c	NN
cord-334133-61om170g	422	106	-	-	HYPH
cord-334133-61om170g	422	107	terminal	terminal	NN
cord-334133-61om170g	422	108	loop	loop	NN
cord-334133-61om170g	422	109	of	of	IN
cord-334133-61om170g	422	110	a	a	DT
cord-334133-61om170g	422	111	neutralizing	neutralize	VBG
cord-334133-61om170g	422	112	antibody	antibody	NN
cord-334133-61om170g	422	113	escape	escape	NN
cord-334133-61om170g	422	114	mutant	mutant	JJ
cord-334133-61om170g	422	115	of	of	IN
cord-334133-61om170g	422	116	human	human	JJ
cord-334133-61om170g	422	117	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	118	virus	virus	NN
cord-334133-61om170g	422	119	type	type	NN
cord-334133-61om170g	422	120	1	1	CD
cord-334133-61om170g	422	121	Alterations	alteration	NNS
cord-334133-61om170g	422	122	in	in	IN
cord-334133-61om170g	422	123	cell	cell	NN
cord-334133-61om170g	422	124	membrane	membrane	NN
cord-334133-61om170g	422	125	permeability	permeability	NN
cord-334133-61om170g	422	126	by	by	IN
cord-334133-61om170g	422	127	the	the	DT
cord-334133-61om170g	422	128	lentiviral	lentiviral	NNP
cord-334133-61om170g	422	129	peptide	peptide	NN
cord-334133-61om170g	422	130	(	(	-LRB-
cord-334133-61om170g	422	131	LLP-1	LLP-1	NNP
cord-334133-61om170g	422	132	)	)	-RRB-
cord-334133-61om170g	422	133	of	of	IN
cord-334133-61om170g	422	134	HIV-1	HIV-1	NNP
cord-334133-61om170g	422	135	transmembrane	transmembrane	NN
cord-334133-61om170g	422	136	protein	protein	NN
cord-334133-61om170g	422	137	Legitimate	legitimate	JJ
cord-334133-61om170g	422	138	and	and	CC
cord-334133-61om170g	422	139	illegitimate	illegitimate	JJ
cord-334133-61om170g	422	140	cleavage	cleavage	NN
cord-334133-61om170g	422	141	of	of	IN
cord-334133-61om170g	422	142	human	human	JJ
cord-334133-61om170g	422	143	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	144	virus	virus	NN
cord-334133-61om170g	422	145	glycoproteins	glycoprotein	NNS
cord-334133-61om170g	422	146	by	by	IN
cord-334133-61om170g	422	147	furin	furin	NN
cord-334133-61om170g	422	148	Kex2p	Kex2p	NNP
cord-334133-61om170g	422	149	:	:	:
cord-334133-61om170g	422	150	a	a	DT
cord-334133-61om170g	422	151	model	model	NN
cord-334133-61om170g	422	152	for	for	IN
cord-334133-61om170g	422	153	cellular	cellular	JJ
cord-334133-61om170g	422	154	endopeptidase	endopeptidase	NN
cord-334133-61om170g	422	155	processing	process	VBG
cord-334133-61om170g	422	156	human	human	JJ
cord-334133-61om170g	422	157	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	158	virus	virus	NN
cord-334133-61om170g	422	159	type	type	NN
cord-334133-61om170g	422	160	1	1	CD
cord-334133-61om170g	422	161	envelope	envelope	NN
cord-334133-61om170g	422	162	glycoprotein	glycoprotein	NN
cord-334133-61om170g	422	163	precursor	precursor	NN
cord-334133-61om170g	422	164	Processing	processing	NN
cord-334133-61om170g	422	165	and	and	CC
cord-334133-61om170g	422	166	routage	routage	NN
cord-334133-61om170g	422	167	of	of	IN
cord-334133-61om170g	422	168	HIV	HIV	NNP
cord-334133-61om170g	422	169	glycoproteins	glycoprotein	NNS
cord-334133-61om170g	422	170	by	by	IN
cord-334133-61om170g	422	171	furin	furin	NN
cord-334133-61om170g	422	172	to	to	IN
cord-334133-61om170g	422	173	the	the	DT
cord-334133-61om170g	422	174	cell	cell	NN
cord-334133-61om170g	422	175	surface	surface	NN
cord-334133-61om170g	422	176	Expression	expression	NN
cord-334133-61om170g	422	177	and	and	CC
cord-334133-61om170g	422	178	immunogenicity	immunogenicity	NN
cord-334133-61om170g	422	179	of	of	IN
cord-334133-61om170g	422	180	an	an	DT
cord-334133-61om170g	422	181	18-residue	18-residue	CD
cord-334133-61om170g	422	182	epitope	epitope	NN
cord-334133-61om170g	422	183	of	of	IN
cord-334133-61om170g	422	184	HIV-1	HIV-1	NNP
cord-334133-61om170g	422	185	gp41	gp41	NNP
cord-334133-61om170g	422	186	inserted	insert	VBN
cord-334133-61om170g	422	187	in	in	IN
cord-334133-61om170g	422	188	the	the	DT
cord-334133-61om170g	422	189	flagellar	flagellar	JJ
cord-334133-61om170g	422	190	protein	protein	NN
cord-334133-61om170g	422	191	of	of	IN
cord-334133-61om170g	422	192	a	a	DT
cord-334133-61om170g	422	193	Salmonella	Salmonella	NNP
cord-334133-61om170g	422	194	live	live	JJ
cord-334133-61om170g	422	195	vaccine	vaccine	NN
cord-334133-61om170g	422	196	Murine	murine	JJ
cord-334133-61om170g	422	197	monoclonal	monoclonal	JJ
cord-334133-61om170g	422	198	antibodies	antibody	NNS
cord-334133-61om170g	422	199	directed	direct	VBN
cord-334133-61om170g	422	200	against	against	IN
cord-334133-61om170g	422	201	the	the	DT
cord-334133-61om170g	422	202	transmembrane	transmembrane	NNP
cord-334133-61om170g	422	203	protein	protein	NN
cord-334133-61om170g	422	204	gp41	gp41	NNP
cord-334133-61om170g	422	205	of	of	IN
cord-334133-61om170g	422	206	human	human	JJ
cord-334133-61om170g	422	207	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	422	208	virus	virus	NN
cord-334133-61om170g	422	209	type	type	NN
cord-334133-61om170g	422	210	1	1	CD
cord-334133-61om170g	422	211	enhance	enhance	VB
cord-334133-61om170g	422	212	its	-PRON-	PRP$
cord-334133-61om170g	422	213	infectivity	infectivity	NN
cord-334133-61om170g	422	214	Interaction	interaction	NN
cord-334133-61om170g	422	215	of	of	IN
cord-334133-61om170g	422	216	tyrosine	tyrosine	NN
cord-334133-61om170g	422	217	-	-	HYPH
cord-334133-61om170g	422	218	based	base	VBN
cord-334133-61om170g	422	219	sorting	sorting	NN
cord-334133-61om170g	422	220	signals	signal	NNS
cord-334133-61om170g	422	221	with	with	IN
cord-334133-61om170g	422	222	clathrin	clathrin	NN
cord-334133-61om170g	422	223	-	-	HYPH
cord-334133-61om170g	422	224	associated	associate	VBN
cord-334133-61om170g	422	225	proteins	protein	NNS
cord-334133-61om170g	423	1	Structural	structural	JJ
cord-334133-61om170g	423	2	determinants	determinant	NNS
cord-334133-61om170g	423	3	of	of	IN
cord-334133-61om170g	423	4	interaction	interaction	NN
cord-334133-61om170g	423	5	of	of	IN
cord-334133-61om170g	423	6	tyrosine	tyrosine	NN
cord-334133-61om170g	423	7	-	-	HYPH
cord-334133-61om170g	423	8	based	base	VBN
cord-334133-61om170g	423	9	sorting	sorting	NN
cord-334133-61om170g	423	10	signals	signal	NNS
cord-334133-61om170g	423	11	with	with	IN
cord-334133-61om170g	423	12	the	the	DT
cord-334133-61om170g	423	13	adaptor	adaptor	NN
cord-334133-61om170g	423	14	medium	medium	NN
cord-334133-61om170g	423	15	chains	chain	NNS
cord-334133-61om170g	423	16	Interaction	Interaction	NNP
cord-334133-61om170g	423	17	of	of	IN
cord-334133-61om170g	423	18	endocytic	endocytic	JJ
cord-334133-61om170g	423	19	signals	signal	NNS
cord-334133-61om170g	423	20	from	from	IN
cord-334133-61om170g	423	21	the	the	DT
cord-334133-61om170g	423	22	HIV-1	HIV-1	NNP
cord-334133-61om170g	423	23	envelope	envelope	NN
cord-334133-61om170g	423	24	glycoprotein	glycoprotein	NN
cord-334133-61om170g	423	25	complex	complex	JJ
cord-334133-61om170g	423	26	with	with	IN
cord-334133-61om170g	423	27	members	member	NNS
cord-334133-61om170g	423	28	of	of	IN
cord-334133-61om170g	423	29	the	the	DT
cord-334133-61om170g	423	30	adaptor	adaptor	NN
cord-334133-61om170g	423	31	medium	medium	NN
cord-334133-61om170g	423	32	chain	chain	NN
cord-334133-61om170g	423	33	family	family	NN
cord-334133-61om170g	424	1	The	the	DT
cord-334133-61om170g	424	2	medium	medium	JJ
cord-334133-61om170g	424	3	subunits	subunit	NNS
cord-334133-61om170g	424	4	of	of	IN
cord-334133-61om170g	424	5	adaptor	adaptor	NN
cord-334133-61om170g	424	6	complexes	complex	NNS
cord-334133-61om170g	424	7	recognise	recognise	VBP
cord-334133-61om170g	424	8	distinct	distinct	JJ
cord-334133-61om170g	424	9	but	but	CC
cord-334133-61om170g	424	10	overlapping	overlapping	JJ
cord-334133-61om170g	424	11	sets	set	NNS
cord-334133-61om170g	424	12	of	of	IN
cord-334133-61om170g	424	13	tyrosine	tyrosine	NN
cord-334133-61om170g	424	14	-	-	HYPH
cord-334133-61om170g	424	15	based	base	VBN
cord-334133-61om170g	424	16	sorting	sorting	NN
cord-334133-61om170g	424	17	signals	signal	NNS
cord-334133-61om170g	424	18	Altered	altered	JJ
cord-334133-61om170g	424	19	expression	expression	NN
cord-334133-61om170g	424	20	of	of	IN
cord-334133-61om170g	424	21	a	a	DT
cord-334133-61om170g	424	22	novel	novel	NN
cord-334133-61om170g	424	23	adaptin	adaptin	NNS
cord-334133-61om170g	424	24	leads	lead	VBZ
cord-334133-61om170g	424	25	to	to	IN
cord-334133-61om170g	424	26	a	a	DT
cord-334133-61om170g	424	27	defective	defective	JJ
cord-334133-61om170g	424	28	pigment	pigment	NN
cord-334133-61om170g	424	29	granule	granule	NN
cord-334133-61om170g	424	30	biogenesis	biogenesis	NN
cord-334133-61om170g	424	31	in	in	IN
cord-334133-61om170g	424	32	the	the	DT
cord-334133-61om170g	424	33	Drosophila	Drosophila	NNP
cord-334133-61om170g	424	34	eye	eye	NN
cord-334133-61om170g	424	35	color	color	NN
cord-334133-61om170g	424	36	mutant	mutant	NN
cord-334133-61om170g	424	37	garnet	garnet	NNP
cord-334133-61om170g	424	38	Folding	Folding	NNP
cord-334133-61om170g	424	39	,	,	,
cord-334133-61om170g	424	40	assembly	assembly	NN
cord-334133-61om170g	424	41	,	,	,
cord-334133-61om170g	424	42	and	and	CC
cord-334133-61om170g	424	43	intracellular	intracellular	JJ
cord-334133-61om170g	424	44	trafficking	trafficking	NN
cord-334133-61om170g	424	45	of	of	IN
cord-334133-61om170g	424	46	the	the	DT
cord-334133-61om170g	424	47	human	human	JJ
cord-334133-61om170g	424	48	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	424	49	virus	virus	NN
cord-334133-61om170g	424	50	type	type	NN
cord-334133-61om170g	424	51	1	1	CD
cord-334133-61om170g	424	52	envelope	envelope	NN
cord-334133-61om170g	424	53	glycoprotein	glycoprotein	NN
cord-334133-61om170g	424	54	analyzed	analyze	VBN
cord-334133-61om170g	424	55	with	with	IN
cord-334133-61om170g	424	56	monoclonal	monoclonal	JJ
cord-334133-61om170g	424	57	antibodies	antibody	NNS
cord-334133-61om170g	424	58	recognizing	recognize	VBG
cord-334133-61om170g	424	59	maturational	maturational	NNP
cord-334133-61om170g	424	60	intermediates	intermediate	NNS
cord-334133-61om170g	425	1	A	a	DT
cord-334133-61om170g	425	2	structural	structural	JJ
cord-334133-61om170g	425	3	explanation	explanation	NN
cord-334133-61om170g	425	4	for	for	IN
cord-334133-61om170g	425	5	the	the	DT
cord-334133-61om170g	425	6	recognition	recognition	NN
cord-334133-61om170g	425	7	of	of	IN
cord-334133-61om170g	425	8	tyrosine	tyrosine	NN
cord-334133-61om170g	425	9	-	-	HYPH
cord-334133-61om170g	425	10	based	base	VBN
cord-334133-61om170g	425	11	endocytotic	endocytotic	NN
cord-334133-61om170g	425	12	signals	signal	NNS
cord-334133-61om170g	426	1	Human	human	JJ
cord-334133-61om170g	426	2	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	426	3	virus	virus	NN
cord-334133-61om170g	426	4	envelope	envelope	NN
cord-334133-61om170g	426	5	protein	protein	NN
cord-334133-61om170g	426	6	determines	determine	VBZ
cord-334133-61om170g	426	7	the	the	DT
cord-334133-61om170g	426	8	site	site	NN
cord-334133-61om170g	426	9	of	of	IN
cord-334133-61om170g	426	10	virus	virus	NN
cord-334133-61om170g	426	11	release	release	NN
cord-334133-61om170g	426	12	in	in	IN
cord-334133-61om170g	426	13	polarized	polarized	JJ
cord-334133-61om170g	426	14	epithelial	epithelial	JJ
cord-334133-61om170g	426	15	cells	cell	NNS
cord-334133-61om170g	426	16	Processing	processing	NN
cord-334133-61om170g	426	17	and	and	CC
cord-334133-61om170g	426	18	secretion	secretion	NN
cord-334133-61om170g	426	19	of	of	IN
cord-334133-61om170g	426	20	envelope	envelope	NN
cord-334133-61om170g	426	21	glycoprotein	glycoprotein	NN
cord-334133-61om170g	426	22	of	of	IN
cord-334133-61om170g	426	23	human	human	JJ
cord-334133-61om170g	426	24	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	426	25	virus	virus	NN
cord-334133-61om170g	426	26	type	type	NN
cord-334133-61om170g	426	27	1	1	CD
cord-334133-61om170g	426	28	in	in	IN
cord-334133-61om170g	426	29	the	the	DT
cord-334133-61om170g	426	30	presence	presence	NN
cord-334133-61om170g	426	31	of	of	IN
cord-334133-61om170g	426	32	trimming	trim	VBG
cord-334133-61om170g	426	33	glucosidase	glucosidase	NNP
cord-334133-61om170g	426	34	inhibitor	inhibitor	NN
cord-334133-61om170g	426	35	deoxynojirimycin	deoxynojirimycin	NNP
cord-334133-61om170g	427	1	Brefeldin	Brefeldin	NNP
cord-334133-61om170g	427	2	A	A	NNP
cord-334133-61om170g	427	3	inhibits	inhibit	VBZ
cord-334133-61om170g	427	4	the	the	DT
cord-334133-61om170g	427	5	processing	processing	NN
cord-334133-61om170g	427	6	and	and	CC
cord-334133-61om170g	427	7	secretion	secretion	NN
cord-334133-61om170g	427	8	of	of	IN
cord-334133-61om170g	427	9	envelope	envelope	NN
cord-334133-61om170g	427	10	glycoprotein	glycoprotein	NN
cord-334133-61om170g	427	11	of	of	IN
cord-334133-61om170g	427	12	human	human	JJ
cord-334133-61om170g	427	13	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	427	14	virus	virus	NN
cord-334133-61om170g	427	15	type	type	NN
cord-334133-61om170g	427	16	1	1	CD
cord-334133-61om170g	427	17	Anatomy	anatomy	NN
cord-334133-61om170g	427	18	of	of	IN
cord-334133-61om170g	427	19	the	the	DT
cord-334133-61om170g	427	20	herpes	herpes	NNP
cord-334133-61om170g	427	21	simplex	simplex	NNP
cord-334133-61om170g	427	22	virus	virus	NN
cord-334133-61om170g	427	23	1	1	CD
cord-334133-61om170g	427	24	strain	strain	NN
cord-334133-61om170g	427	25	F	F	NNP
cord-334133-61om170g	427	26	glycoprotein	glycoprotein	NN
cord-334133-61om170g	427	27	B	b	NN
cord-334133-61om170g	427	28	gene	gene	NN
cord-334133-61om170g	427	29	:	:	:
cord-334133-61om170g	427	30	primary	primary	JJ
cord-334133-61om170g	427	31	sequence	sequence	NN
cord-334133-61om170g	427	32	and	and	CC
cord-334133-61om170g	427	33	predicted	predict	VBD
cord-334133-61om170g	427	34	protein	protein	NN
cord-334133-61om170g	427	35	structure	structure	NN
cord-334133-61om170g	427	36	of	of	IN
cord-334133-61om170g	427	37	the	the	DT
cord-334133-61om170g	427	38	wild	wild	JJ
cord-334133-61om170g	427	39	type	type	NN
cord-334133-61om170g	427	40	and	and	CC
cord-334133-61om170g	427	41	of	of	IN
cord-334133-61om170g	427	42	monoclonal	monoclonal	JJ
cord-334133-61om170g	427	43	antibody	antibody	NN
cord-334133-61om170g	427	44	-	-	HYPH
cord-334133-61om170g	427	45	resistant	resistant	JJ
cord-334133-61om170g	427	46	mutants	mutant	NNS
cord-334133-61om170g	427	47	Transfer	transfer	NN
cord-334133-61om170g	427	48	of	of	IN
cord-334133-61om170g	427	49	endoplasmic	endoplasmic	NN
cord-334133-61om170g	427	50	reticulum	reticulum	NN
cord-334133-61om170g	427	51	and	and	CC
cord-334133-61om170g	427	52	Golgi	Golgi	NNP
cord-334133-61om170g	427	53	retention	retention	NN
cord-334133-61om170g	427	54	signals	signal	NNS
cord-334133-61om170g	427	55	to	to	IN
cord-334133-61om170g	427	56	human	human	JJ
cord-334133-61om170g	427	57	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	427	58	virus	virus	NN
cord-334133-61om170g	427	59	type	type	NN
cord-334133-61om170g	428	1	1	1	CD
cord-334133-61om170g	428	2	gp160	gp160	NNP
cord-334133-61om170g	428	3	inhibits	inhibit	VBZ
cord-334133-61om170g	428	4	intracellular	intracellular	JJ
cord-334133-61om170g	428	5	transport	transport	NN
cord-334133-61om170g	428	6	and	and	CC
cord-334133-61om170g	428	7	proteolytic	proteolytic	JJ
cord-334133-61om170g	428	8	processing	processing	NN
cord-334133-61om170g	428	9	of	of	IN
cord-334133-61om170g	428	10	viral	viral	JJ
cord-334133-61om170g	428	11	glycoprotein	glycoprotein	NN
cord-334133-61om170g	428	12	but	but	CC
cord-334133-61om170g	428	13	does	do	VBZ
cord-334133-61om170g	428	14	not	not	RB
cord-334133-61om170g	428	15	influence	influence	VB
cord-334133-61om170g	428	16	the	the	DT
cord-334133-61om170g	428	17	cellular	cellular	JJ
cord-334133-61om170g	428	18	site	site	NN
cord-334133-61om170g	428	19	of	of	IN
cord-334133-61om170g	428	20	virus	virus	NN
cord-334133-61om170g	428	21	particle	particle	NN
cord-334133-61om170g	428	22	budding	bud	VBG
cord-334133-61om170g	428	23	Novel	novel	JJ
cord-334133-61om170g	428	24	transmembrane	transmembrane	NN
cord-334133-61om170g	428	25	topology	topology	NN
cord-334133-61om170g	428	26	of	of	IN
cord-334133-61om170g	428	27	the	the	DT
cord-334133-61om170g	428	28	hepatitis	hepatitis	NN
cord-334133-61om170g	428	29	B	B	NNP
cord-334133-61om170g	428	30	envelope	envelope	NN
cord-334133-61om170g	429	1	proteins	protein	NNS
cord-334133-61om170g	430	1	An	an	DT
cord-334133-61om170g	430	2	internalization	internalization	NN
cord-334133-61om170g	430	3	motif	motif	NN
cord-334133-61om170g	430	4	is	be	VBZ
cord-334133-61om170g	430	5	created	create	VBN
cord-334133-61om170g	430	6	in	in	IN
cord-334133-61om170g	430	7	the	the	DT
cord-334133-61om170g	430	8	first	first	JJ
cord-334133-61om170g	430	9	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	430	10	domain	domain	NN
cord-334133-61om170g	430	11	of	of	IN
cord-334133-61om170g	430	12	the	the	DT
cord-334133-61om170g	430	13	transferrin	transferrin	NN
cord-334133-61om170g	430	14	receptor	receptor	NN
cord-334133-61om170g	430	15	by	by	IN
cord-334133-61om170g	430	16	substitution	substitution	NN
cord-334133-61om170g	430	17	of	of	IN
cord-334133-61om170g	430	18	a	a	DT
cord-334133-61om170g	430	19	tyrosine	tyrosine	NN
cord-334133-61om170g	430	20	at	at	IN
cord-334133-61om170g	430	21	the	the	DT
cord-334133-61om170g	430	22	first	first	JJ
cord-334133-61om170g	430	23	position	position	NN
cord-334133-61om170g	430	24	of	of	IN
cord-334133-61om170g	430	25	a	a	DT
cord-334133-61om170g	430	26	predicted	predict	VBN
cord-334133-61om170g	430	27	turn	turn	NN
cord-334133-61om170g	430	28	Complete	complete	JJ
cord-334133-61om170g	430	29	nucleotide	nucleotide	JJ
cord-334133-61om170g	430	30	sequence	sequence	NN
cord-334133-61om170g	430	31	of	of	IN
cord-334133-61om170g	430	32	the	the	DT
cord-334133-61om170g	430	33	AIDS	AIDS	NNP
cord-334133-61om170g	430	34	virus	virus	NN
cord-334133-61om170g	430	35	,	,	,
cord-334133-61om170g	430	36	HTLV	HTLV	NNP
cord-334133-61om170g	430	37	-	-	HYPH
cord-334133-61om170g	430	38	III	III	NNP
cord-334133-61om170g	430	39	A	a	DT
cord-334133-61om170g	430	40	novel	novel	JJ
cord-334133-61om170g	430	41	monoclonal	monoclonal	JJ
cord-334133-61om170g	430	42	antibody	antibody	NN
cord-334133-61om170g	430	43	specific	specific	JJ
cord-334133-61om170g	430	44	for	for	IN
cord-334133-61om170g	430	45	the	the	DT
cord-334133-61om170g	430	46	C	C	NNP
cord-334133-61om170g	430	47	-	-	HYPH
cord-334133-61om170g	430	48	terminal	terminal	NN
cord-334133-61om170g	430	49	tail	tail	NN
cord-334133-61om170g	430	50	of	of	IN
cord-334133-61om170g	430	51	the	the	DT
cord-334133-61om170g	430	52	gp41	gp41	NNP
cord-334133-61om170g	430	53	envelope	envelope	NN
cord-334133-61om170g	430	54	transmembrane	transmembrane	NN
cord-334133-61om170g	430	55	protein	protein	NN
cord-334133-61om170g	430	56	of	of	IN
cord-334133-61om170g	430	57	human	human	JJ
cord-334133-61om170g	430	58	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	430	59	virus	virus	NN
cord-334133-61om170g	430	60	type	type	NN
cord-334133-61om170g	430	61	1	1	CD
cord-334133-61om170g	430	62	that	that	WDT
cord-334133-61om170g	430	63	preferentially	preferentially	RB
cord-334133-61om170g	430	64	neutralizes	neutralize	VBZ
cord-334133-61om170g	430	65	virus	virus	NN
cord-334133-61om170g	430	66	after	after	IN
cord-334133-61om170g	430	67	it	-PRON-	PRP
cord-334133-61om170g	430	68	has	have	VBZ
cord-334133-61om170g	430	69	attached	attach	VBN
cord-334133-61om170g	430	70	to	to	IN
cord-334133-61om170g	430	71	the	the	DT
cord-334133-61om170g	430	72	target	target	NN
cord-334133-61om170g	430	73	cell	cell	NN
cord-334133-61om170g	430	74	and	and	CC
cord-334133-61om170g	430	75	inhibits	inhibit	VBZ
cord-334133-61om170g	430	76	the	the	DT
cord-334133-61om170g	430	77	production	production	NN
cord-334133-61om170g	430	78	of	of	IN
cord-334133-61om170g	430	79	infectious	infectious	JJ
cord-334133-61om170g	430	80	progeny	progeny	NN
cord-334133-61om170g	430	81	Membrane	membrane	NN
cord-334133-61om170g	430	82	protein	protein	NN
cord-334133-61om170g	430	83	molecules	molecule	NNS
cord-334133-61om170g	430	84	of	of	IN
cord-334133-61om170g	430	85	transmissible	transmissible	JJ
cord-334133-61om170g	430	86	gastroenteritis	gastroenteritis	JJ
cord-334133-61om170g	430	87	coronavirus	coronavirus	NN
cord-334133-61om170g	430	88	also	also	RB
cord-334133-61om170g	430	89	expose	expose	VBP
cord-334133-61om170g	430	90	the	the	DT
cord-334133-61om170g	430	91	carboxy	carboxy	JJ
cord-334133-61om170g	430	92	-	-	HYPH
cord-334133-61om170g	430	93	terminal	terminal	NN
cord-334133-61om170g	430	94	region	region	NN
cord-334133-61om170g	430	95	on	on	IN
cord-334133-61om170g	430	96	the	the	DT
cord-334133-61om170g	430	97	external	external	JJ
cord-334133-61om170g	430	98	surface	surface	NN
cord-334133-61om170g	430	99	of	of	IN
cord-334133-61om170g	430	100	the	the	DT
cord-334133-61om170g	430	101	virion	virion	NN
cord-334133-61om170g	431	1	The	the	DT
cord-334133-61om170g	431	2	targeting	targeting	JJ
cord-334133-61om170g	431	3	signal	signal	NN
cord-334133-61om170g	431	4	of	of	IN
cord-334133-61om170g	431	5	lamp1	lamp1	NN
cord-334133-61om170g	431	6	to	to	IN
cord-334133-61om170g	431	7	lysosomes	lysosome	NNS
cord-334133-61om170g	431	8	is	be	VBZ
cord-334133-61om170g	431	9	dependent	dependent	JJ
cord-334133-61om170g	431	10	on	on	IN
cord-334133-61om170g	431	11	the	the	DT
cord-334133-61om170g	431	12	spacing	spacing	NN
cord-334133-61om170g	431	13	of	of	IN
cord-334133-61om170g	431	14	its	-PRON-	PRP$
cord-334133-61om170g	431	15	cytoplasmic	cytoplasmic	JJ
cord-334133-61om170g	431	16	tail	tail	NN
cord-334133-61om170g	431	17	tyrosine	tyrosine	NN
cord-334133-61om170g	431	18	sorting	sorting	NN
cord-334133-61om170g	431	19	motif	motif	NN
cord-334133-61om170g	431	20	relative	relative	JJ
cord-334133-61om170g	431	21	to	to	IN
cord-334133-61om170g	431	22	the	the	DT
cord-334133-61om170g	431	23	membrane	membrane	NN
cord-334133-61om170g	431	24	Endocytosis	Endocytosis	NNP
cord-334133-61om170g	431	25	of	of	IN
cord-334133-61om170g	431	26	endogenously	endogenously	RB
cord-334133-61om170g	431	27	synthesized	synthesize	VBN
cord-334133-61om170g	431	28	HIV-1	HIV-1	NNP
cord-334133-61om170g	431	29	envelope	envelope	NN
cord-334133-61om170g	431	30	protein	protein	NN
cord-334133-61om170g	431	31	:	:	:
cord-334133-61om170g	431	32	mechanism	mechanism	NN
cord-334133-61om170g	431	33	and	and	CC
cord-334133-61om170g	431	34	role	role	NN
cord-334133-61om170g	431	35	in	in	IN
cord-334133-61om170g	431	36	processing	processing	NN
cord-334133-61om170g	431	37	for	for	IN
cord-334133-61om170g	431	38	association	association	NN
cord-334133-61om170g	431	39	with	with	IN
cord-334133-61om170g	431	40	class	class	NNP
cord-334133-61om170g	431	41	II	II	NNP
cord-334133-61om170g	431	42	MHC	MHC	NNP
cord-334133-61om170g	431	43	Mechanisms	Mechanisms	NNPS
cord-334133-61om170g	431	44	for	for	IN
cord-334133-61om170g	431	45	the	the	DT
cord-334133-61om170g	431	46	incorporation	incorporation	NN
cord-334133-61om170g	431	47	of	of	IN
cord-334133-61om170g	431	48	proteins	protein	NNS
cord-334133-61om170g	431	49	in	in	IN
cord-334133-61om170g	431	50	membranes	membrane	NNS
cord-334133-61om170g	431	51	and	and	CC
cord-334133-61om170g	431	52	organelles	organelle	NNS
cord-334133-61om170g	432	1	Transmembrane	Transmembrane	NNP
cord-334133-61om170g	432	2	h	h	NN
cord-334133-61om170g	432	3	-	-	HYPH
cord-334133-61om170g	432	4	barrel	barrel	NN
cord-334133-61om170g	432	5	proteins	protein	NNS
cord-334133-61om170g	432	6	Characterization	characterization	NN
cord-334133-61om170g	432	7	of	of	IN
cord-334133-61om170g	432	8	the	the	DT
cord-334133-61om170g	432	9	adaptor	adaptor	NN
cord-334133-61om170g	432	10	-	-	HYPH
cord-334133-61om170g	432	11	related	relate	VBN
cord-334133-61om170g	432	12	protein	protein	NN
cord-334133-61om170g	432	13	complex	complex	NN
cord-334133-61om170g	432	14	,	,	,
cord-334133-61om170g	432	15	AP-3	AP-3	NNP
cord-334133-61om170g	433	1	The	the	DT
cord-334133-61om170g	433	2	structure	structure	NN
cord-334133-61om170g	433	3	and	and	CC
cord-334133-61om170g	433	4	insertion	insertion	NN
cord-334133-61om170g	433	5	of	of	IN
cord-334133-61om170g	433	6	integral	integral	JJ
cord-334133-61om170g	433	7	proteins	protein	NNS
cord-334133-61om170g	433	8	in	in	IN
cord-334133-61om170g	433	9	membrane	membrane	NN
cord-334133-61om170g	434	1	The	the	DT
cord-334133-61om170g	434	2	molecular	molecular	JJ
cord-334133-61om170g	434	3	biology	biology	NN
cord-334133-61om170g	434	4	of	of	IN
cord-334133-61om170g	434	5	arteriviruses	arteriviruse	NNS
cord-334133-61om170g	435	1	Intracellular	Intracellular	NNP
cord-334133-61om170g	435	2	processing	processing	NN
cord-334133-61om170g	435	3	of	of	IN
cord-334133-61om170g	435	4	the	the	DT
cord-334133-61om170g	435	5	gp160	gp160	NNP
cord-334133-61om170g	435	6	HIV-1	HIV-1	NNP
cord-334133-61om170g	435	7	envelope	envelope	NN
cord-334133-61om170g	435	8	precursor	precursor	NN
cord-334133-61om170g	435	9	.	.	.
cord-334133-61om170g	436	1	Endoproteolytic	endoproteolytic	JJ
cord-334133-61om170g	436	2	cleavage	cleavage	NN
cord-334133-61om170g	436	3	occurs	occur	VBZ
cord-334133-61om170g	436	4	in	in	IN
cord-334133-61om170g	436	5	a	a	DT
cord-334133-61om170g	436	6	cis	cis	NNP
cord-334133-61om170g	436	7	or	or	CC
cord-334133-61om170g	436	8	medial	medial	JJ
cord-334133-61om170g	436	9	compartment	compartment	NN
cord-334133-61om170g	436	10	of	of	IN
cord-334133-61om170g	436	11	the	the	DT
cord-334133-61om170g	436	12	Golgi	Golgi	NNP
cord-334133-61om170g	436	13	complex	complex	NN
cord-334133-61om170g	436	14	Specificity	specificity	NN
cord-334133-61om170g	436	15	of	of	IN
cord-334133-61om170g	436	16	interaction	interaction	NN
cord-334133-61om170g	436	17	between	between	IN
cord-334133-61om170g	436	18	adaptor	adaptor	NN
cord-334133-61om170g	436	19	-	-	HYPH
cord-334133-61om170g	436	20	complex	complex	JJ
cord-334133-61om170g	436	21	medium	medium	NN
cord-334133-61om170g	436	22	chains	chain	NNS
cord-334133-61om170g	436	23	and	and	CC
cord-334133-61om170g	436	24	the	the	DT
cord-334133-61om170g	436	25	tyrosine	tyrosine	NN
cord-334133-61om170g	436	26	-	-	HYPH
cord-334133-61om170g	436	27	based	base	VBN
cord-334133-61om170g	436	28	sorting	sorting	NN
cord-334133-61om170g	436	29	signals	signal	NNS
cord-334133-61om170g	436	30	of	of	IN
cord-334133-61om170g	436	31	TGN38	TGN38	NNS
cord-334133-61om170g	436	32	and	and	CC
cord-334133-61om170g	437	1	Igp120	igp120	DT
cord-334133-61om170g	438	1	The	the	DT
cord-334133-61om170g	438	2	yeast	yeast	NN
cord-334133-61om170g	438	3	adaptor	adaptor	NN
cord-334133-61om170g	438	4	protein	protein	NN
cord-334133-61om170g	438	5	complex	complex	NN
cord-334133-61om170g	438	6	,	,	,
cord-334133-61om170g	438	7	AP-3	AP-3	NNP
cord-334133-61om170g	438	8	,	,	,
cord-334133-61om170g	438	9	is	be	VBZ
cord-334133-61om170g	438	10	essential	essential	JJ
cord-334133-61om170g	438	11	for	for	IN
cord-334133-61om170g	438	12	the	the	DT
cord-334133-61om170g	438	13	efficient	efficient	JJ
cord-334133-61om170g	438	14	delivery	delivery	NN
cord-334133-61om170g	438	15	of	of	IN
cord-334133-61om170g	438	16	alkaline	alkaline	JJ
cord-334133-61om170g	438	17	phosphatase	phosphatase	NN
cord-334133-61om170g	438	18	by	by	IN
cord-334133-61om170g	438	19	the	the	DT
cord-334133-61om170g	438	20	alternate	alternate	JJ
cord-334133-61om170g	438	21	pathway	pathway	NN
cord-334133-61om170g	438	22	to	to	IN
cord-334133-61om170g	438	23	the	the	DT
cord-334133-61om170g	438	24	vacuole	vacuole	NN
cord-334133-61om170g	438	25	Correlation	correlation	NN
cord-334133-61om170g	438	26	of	of	IN
cord-334133-61om170g	438	27	sequence	sequence	NN
cord-334133-61om170g	438	28	hydrophobicities	hydrophobicity	NNS
cord-334133-61om170g	438	29	measures	measure	VBZ
cord-334133-61om170g	438	30	similarity	similarity	NN
cord-334133-61om170g	438	31	in	in	IN
cord-334133-61om170g	438	32	three	three	CD
cord-334133-61om170g	438	33	dimensional	dimensional	JJ
cord-334133-61om170g	438	34	protein	protein	NN
cord-334133-61om170g	438	35	structure	structure	NN
cord-334133-61om170g	438	36	Structural	structural	JJ
cord-334133-61om170g	438	37	requirements	requirement	NNS
cord-334133-61om170g	438	38	for	for	IN
cord-334133-61om170g	438	39	high	high	JJ
cord-334133-61om170g	438	40	efficiency	efficiency	NN
cord-334133-61om170g	438	41	endocytosis	endocytosis	NN
cord-334133-61om170g	438	42	of	of	IN
cord-334133-61om170g	438	43	the	the	DT
cord-334133-61om170g	438	44	human	human	JJ
cord-334133-61om170g	438	45	transferrin	transferrin	NN
cord-334133-61om170g	438	46	receptor	receptor	NN
cord-334133-61om170g	438	47	Signal	signal	NN
cord-334133-61om170g	438	48	-	-	HYPH
cord-334133-61om170g	438	49	dependent	dependent	JJ
cord-334133-61om170g	438	50	membrane	membrane	NN
cord-334133-61om170g	438	51	protein	protein	NN
cord-334133-61om170g	438	52	trafficking	trafficking	NN
cord-334133-61om170g	438	53	in	in	IN
cord-334133-61om170g	438	54	the	the	DT
cord-334133-61om170g	438	55	endocytic	endocytic	JJ
cord-334133-61om170g	438	56	pathway	pathway	NN
cord-334133-61om170g	438	57	Characterization	characterization	NN
cord-334133-61om170g	438	58	and	and	CC
cord-334133-61om170g	438	59	primary	primary	JJ
cord-334133-61om170g	438	60	structure	structure	NN
cord-334133-61om170g	438	61	of	of	IN
cord-334133-61om170g	438	62	a	a	DT
cord-334133-61om170g	438	63	human	human	JJ
cord-334133-61om170g	438	64	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	438	65	virus	virus	NN
cord-334133-61om170g	438	66	type	type	NN
cord-334133-61om170g	438	67	1	1	CD
cord-334133-61om170g	438	68	(	(	-LRB-
cord-334133-61om170g	438	69	HIV-1	HIV-1	NNP
cord-334133-61om170g	438	70	)	)	-RRB-
cord-334133-61om170g	438	71	neutralization	neutralization	NN
cord-334133-61om170g	438	72	domain	domain	NN
cord-334133-61om170g	438	73	as	as	IN
cord-334133-61om170g	438	74	presented	present	VBN
cord-334133-61om170g	438	75	by	by	IN
cord-334133-61om170g	438	76	a	a	DT
cord-334133-61om170g	438	77	poliovirus	poliovirus	NN
cord-334133-61om170g	438	78	type	type	NN
cord-334133-61om170g	438	79	1	1	CD
cord-334133-61om170g	438	80	/	/	SYM
cord-334133-61om170g	438	81	HIV-1	HIV-1	NNP
cord-334133-61om170g	438	82	chimera	chimera	NN
cord-334133-61om170g	438	83	Comparative	Comparative	NNP
cord-334133-61om170g	438	84	cellular	cellular	JJ
cord-334133-61om170g	438	85	processing	processing	NN
cord-334133-61om170g	438	86	of	of	IN
cord-334133-61om170g	438	87	the	the	DT
cord-334133-61om170g	438	88	human	human	JJ
cord-334133-61om170g	438	89	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	438	90	virus	virus	NN
cord-334133-61om170g	438	91	(	(	-LRB-
cord-334133-61om170g	438	92	HIV-1	HIV-1	NNP
cord-334133-61om170g	438	93	)	)	-RRB-
cord-334133-61om170g	438	94	envelope	envelope	NN
cord-334133-61om170g	438	95	glycoprotein	glycoprotein	NN
cord-334133-61om170g	438	96	gp160	gp160	NNP
cord-334133-61om170g	438	97	by	by	IN
cord-334133-61om170g	438	98	the	the	DT
cord-334133-61om170g	438	99	mammalian	mammalian	JJ
cord-334133-61om170g	438	100	subtilisin	subtilisin	NNP
cord-334133-61om170g	438	101	/	/	SYM
cord-334133-61om170g	438	102	kexin	kexin	NN
cord-334133-61om170g	438	103	-	-	HYPH
cord-334133-61om170g	438	104	like	like	JJ
cord-334133-61om170g	438	105	convertases	convertases	NNP
cord-334133-61om170g	438	106	Mutations	Mutations	NNPS
cord-334133-61om170g	438	107	within	within	IN
cord-334133-61om170g	438	108	the	the	DT
cord-334133-61om170g	438	109	putative	putative	JJ
cord-334133-61om170g	438	110	membrane	membrane	NN
cord-334133-61om170g	438	111	-	-	HYPH
cord-334133-61om170g	438	112	spanning	span	VBG
cord-334133-61om170g	438	113	domain	domain	NN
cord-334133-61om170g	438	114	of	of	IN
cord-334133-61om170g	438	115	the	the	DT
cord-334133-61om170g	438	116	simian	simian	JJ
cord-334133-61om170g	438	117	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	438	118	virus	virus	NN
cord-334133-61om170g	438	119	transmembrane	transmembrane	NNP
cord-334133-61om170g	438	120	glycoprotein	glycoprotein	NN
cord-334133-61om170g	438	121	define	define	VBP
cord-334133-61om170g	438	122	the	the	DT
cord-334133-61om170g	438	123	minimal	minimal	JJ
cord-334133-61om170g	438	124	requirements	requirement	NNS
cord-334133-61om170g	438	125	for	for	IN
cord-334133-61om170g	438	126	fusion	fusion	NN
cord-334133-61om170g	438	127	,	,	,
cord-334133-61om170g	438	128	incorporation	incorporation	NN
cord-334133-61om170g	438	129	and	and	CC
cord-334133-61om170g	438	130	infectivity	infectivity	NN
cord-334133-61om170g	438	131	Mutation	Mutation	NNP
cord-334133-61om170g	438	132	of	of	IN
cord-334133-61om170g	438	133	the	the	DT
cord-334133-61om170g	438	134	dominant	dominant	JJ
cord-334133-61om170g	438	135	endocytosis	endocytosis	NN
cord-334133-61om170g	438	136	motif	motif	NN
cord-334133-61om170g	438	137	in	in	IN
cord-334133-61om170g	438	138	human	human	JJ
cord-334133-61om170g	438	139	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	438	140	virus	virus	NN
cord-334133-61om170g	438	141	type	type	NN
cord-334133-61om170g	438	142	1	1	CD
cord-334133-61om170g	438	143	gp41	gp41	NNP
cord-334133-61om170g	438	144	can	can	MD
cord-334133-61om170g	438	145	complement	complement	VB
cord-334133-61om170g	438	146	matrix	matrix	NN
cord-334133-61om170g	438	147	mutations	mutation	NNS
cord-334133-61om170g	438	148	without	without	IN
cord-334133-61om170g	438	149	increasing	increase	VBG
cord-334133-61om170g	438	150	Env	env	NN
cord-334133-61om170g	438	151	incorporation	incorporation	NN
cord-334133-61om170g	438	152	Viral	viral	JJ
cord-334133-61om170g	438	153	and	and	CC
cord-334133-61om170g	438	154	cellular	cellular	JJ
cord-334133-61om170g	438	155	membrane	membrane	NN
cord-334133-61om170g	438	156	fusion	fusion	NN
cord-334133-61om170g	438	157	reactions	reaction	NNS
cord-334133-61om170g	439	1	Biosynthesis	Biosynthesis	NNP
cord-334133-61om170g	439	2	,	,	,
cord-334133-61om170g	439	3	cleavage	cleavage	NN
cord-334133-61om170g	439	4	,	,	,
cord-334133-61om170g	439	5	and	and	CC
cord-334133-61om170g	439	6	degradation	degradation	NN
cord-334133-61om170g	439	7	of	of	IN
cord-334133-61om170g	439	8	the	the	DT
cord-334133-61om170g	439	9	human	human	JJ
cord-334133-61om170g	439	10	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	439	11	virus	virus	NN
cord-334133-61om170g	439	12	type	type	NN
cord-334133-61om170g	439	13	1	1	CD
cord-334133-61om170g	439	14	envelope	envelope	NN
cord-334133-61om170g	439	15	glycoprotein	glycoprotein	NN
cord-334133-61om170g	439	16	gp160	gp160	NNP
cord-334133-61om170g	439	17	Mutations	Mutations	NNPS
cord-334133-61om170g	439	18	with	with	IN
cord-334133-61om170g	439	19	the	the	DT
cord-334133-61om170g	439	20	human	human	JJ
cord-334133-61om170g	439	21	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	439	22	virus	virus	NN
cord-334133-61om170g	439	23	type	type	NN
cord-334133-61om170g	439	24	1	1	CD
cord-334133-61om170g	439	25	gp160	gp160	NNP
cord-334133-61om170g	439	26	glycoprotein	glycoprotein	NN
cord-334133-61om170g	439	27	alter	alter	VB
cord-334133-61om170g	439	28	its	-PRON-	PRP$
cord-334133-61om170g	439	29	intracellular	intracellular	JJ
cord-334133-61om170g	439	30	transport	transport	NN
cord-334133-61om170g	439	31	and	and	CC
cord-334133-61om170g	439	32	processing	process	VBG
cord-334133-61om170g	439	33	The	the	DT
cord-334133-61om170g	439	34	highly	highly	RB
cord-334133-61om170g	439	35	conserved	conserve	VBN
cord-334133-61om170g	439	36	C	c	NN
cord-334133-61om170g	439	37	-	-	HYPH
cord-334133-61om170g	439	38	terminal	terminal	NN
cord-334133-61om170g	439	39	dileucine	dileucine	NN
cord-334133-61om170g	439	40	motif	motif	NN
cord-334133-61om170g	439	41	in	in	IN
cord-334133-61om170g	439	42	the	the	DT
cord-334133-61om170g	439	43	cytosolic	cytosolic	JJ
cord-334133-61om170g	439	44	domain	domain	NN
cord-334133-61om170g	439	45	of	of	IN
cord-334133-61om170g	439	46	the	the	DT
cord-334133-61om170g	439	47	human	human	JJ
cord-334133-61om170g	439	48	immunodeficiency	immunodeficiency	NN
cord-334133-61om170g	439	49	virus	virus	NN
cord-334133-61om170g	439	50	type	type	NN
cord-334133-61om170g	439	51	1	1	CD
cord-334133-61om170g	439	52	envelope	envelope	NN
cord-334133-61om170g	439	53	glycoprotein	glycoprotein	NN
cord-334133-61om170g	439	54	is	be	VBZ
cord-334133-61om170g	439	55	critical	critical	JJ
cord-334133-61om170g	439	56	for	for	IN
cord-334133-61om170g	439	57	its	-PRON-	PRP$
cord-334133-61om170g	439	58	association	association	NN
cord-334133-61om170g	439	59	with	with	IN
cord-334133-61om170g	439	60	the	the	DT
cord-334133-61om170g	439	61	AP-1	AP-1	NNP
cord-334133-61om170g	439	62	clathrin	clathrin	NN
cord-334133-61om170g	439	63	adaptor	adaptor	NN
cord-334133-61om170g	439	64	Amphipathic	Amphipathic	NNP
cord-334133-61om170g	439	65	domains	domain	NNS
cord-334133-61om170g	439	66	in	in	IN
cord-334133-61om170g	439	67	the	the	DT
cord-334133-61om170g	439	68	C	C	NNP
cord-334133-61om170g	439	69	terminus	terminus	NN
cord-334133-61om170g	439	70	of	of	IN
cord-334133-61om170g	439	71	the	the	DT
cord-334133-61om170g	439	72	transmembrane	transmembrane	NNP
cord-334133-61om170g	439	73	protein	protein	NN
cord-334133-61om170g	439	74	(	(	-LRB-
cord-334133-61om170g	439	75	gp41	gp41	NNP
cord-334133-61om170g	439	76	)	)	-RRB-
cord-334133-61om170g	439	77	permeabilize	permeabilize	NNP
cord-334133-61om170g	439	78	HIV-1	HIV-1	NNP
cord-334133-61om170g	439	79	virions	virion	NNS
cord-334133-61om170g	439	80	:	:	:
cord-334133-61om170g	439	81	a	a	DT
cord-334133-61om170g	439	82	molecular	molecular	JJ
cord-334133-61om170g	439	83	mechanism	mechanism	NN
cord-334133-61om170g	439	84	underlying	underlie	VBG
cord-334133-61om170g	439	85	natural	natural	JJ
cord-334133-61om170g	439	86	endogenous	endogenous	JJ
cord-334133-61om170g	439	87	reverse	reverse	NN
cord-334133-61om170g	439	88	transcription	transcription	NN
cord-334133-61om170g	440	1	The	the	DT
cord-334133-61om170g	440	2	characterization	characterization	NN
cord-334133-61om170g	440	3	of	of	IN
cord-334133-61om170g	440	4	amino	amino	JJ
cord-334133-61om170g	440	5	acids	acid	NNS
cord-334133-61om170g	440	6	in	in	IN
cord-334133-61om170g	440	7	proteins	protein	NNS
cord-334133-61om170g	440	8	by	by	IN
cord-334133-61om170g	440	9	statistical	statistical	JJ
cord-334133-61om170g	440	10	methods	method	NNS
cord-334133-61om170g	441	1	We	-PRON-	PRP
cord-334133-61om170g	441	2	thank	thank	VBP
cord-334133-61om170g	441	3	Richard	Richard	NNP
cord-334133-61om170g	441	4	Compans	Compans	NNP
cord-334133-61om170g	441	5	for	for	IN
cord-334133-61om170g	441	6	reading	read	VBG
cord-334133-61om170g	441	7	the	the	DT
cord-334133-61om170g	441	8	manuscript	manuscript	NN
cord-334133-61om170g	441	9	and	and	CC
cord-334133-61om170g	441	10	his	-PRON-	PRP$
cord-334133-61om170g	441	11	advice	advice	NN
cord-334133-61om170g	441	12	and	and	CC
cord-334133-61om170g	441	13	are	be	VBP
cord-334133-61om170g	441	14	pleased	pleased	JJ
cord-334133-61om170g	441	15	to	to	TO
cord-334133-61om170g	441	16	acknowledge	acknowledge	VB
cord-334133-61om170g	441	17	the	the	DT
cord-334133-61om170g	441	18	financial	financial	JJ
cord-334133-61om170g	441	19	support	support	NN
cord-334133-61om170g	441	20	of	of	IN
cord-334133-61om170g	441	21	AVERT	avert	VB
cord-334133-61om170g	441	22	,	,	,
cord-334133-61om170g	441	23	UK	UK	NNP
cord-334133-61om170g	441	24	.	.	.