id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258294-ny3xrjzc	Gao, Xiang	Characterization, Pathogenicity and Protective efficacy of a Cell Culture-Derived Porcine Deltacoronavirus	2020-04-02		.txt	text/plain	6045	298	53	Compared with nonvaccinated pigs, conventional weaned pigs given the inactivated vaccine developed a potent humoral immune response and showed no clinical signs or viral shedding after challenge, indicating a potent protective effect of the vaccine against PDCoV infection. Piglets in the infection group and mock control group were separately inoculated with 3 ml of MEM containing 1.0×10 4 TCID50 of the cell culture-adapted PDCoV strain CH/XJYN/2016-P6. To determine a standardized and validated dose for the subsequent pig challenge experiments, the median pig diarrhea dose (PDD50) of P6 of the cell culture-adapted PDCoV strain, CH/XJYN/2016, was determined by using conventional weaned pigs as described in our previous study (Zhang et al., 2019a) . Therefore, the infectious titer (PDD50) of PDCoV in two-month-old conventional pigs and the protection efficacity of an inactivated vaccine based on the cell-adapted strain CH/XJYN/2016 were determined for the first time in the present study.	./cache/cord-258294-ny3xrjzc.txt	./txt/cord-258294-ny3xrjzc.txt