id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259671-7de21oaq	Madhugiri, Ramakanth	RNA structure analysis of alphacoronavirus terminal genome regions	2014-12-19		.txt	text/plain	11161	568	50	Overall, the conservation pattern identified for 5′ and 3′-terminal RNA structural elements in the genomes of alphaand betacoronaviruses is in agreement with the widely used replicase polyprotein-based classification of the Coronavirinae, suggesting co-evolution of the coronavirus replication machinery with cognate cis-acting RNA elements. Other internal cis-acting elements include specific RNA signals required for genome packing, which have been characterized in a small number of coronaviruses Escors et al., 2003; Morales et al., 2013; Penzes et al., 1994) , and a complex RNA pseudoknot structure located in the ORF1a-ORF1b overlap region that mediates a (−1) ribosomal frameshift event and thus controls the expression of the second large ORF on the coronavirus genome RNA (ORF1b) (Brierley et al., 1987 (Brierley et al., , 1989 de Haan et al., 2002; Namy et al., 2006) .	./cache/cord-259671-7de21oaq.txt	./txt/cord-259671-7de21oaq.txt