id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267362-l4288mxw	Shi, Xibao	Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells	2010-08-06		.txt	text/plain	3889	222	55	title: Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-β promoter activity in MARC-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3. These PAMPs recruit different adaptor proteins, for example, TLRs recruits the adaptor molecule myeloid differentiation primary-response gene 88(MyD88) and Toll/IL-1 receptor domain-containing adaptor inducing IFN(TRIF) while RIG-I recruits virus-induced signaling adapter (VISA), to make TANK-binding kinase 1 (TBK1) or IB kinase-(IKK-) phosphorylate IRF-3 and finally to induce IFN-␤ transcription (Bowie and Unterholzner, 2008) . So, the purpose of the present experiments is to analyze the patterns of IFN-␤ promoter activity in MARC-145 cells during infection with PRRSV and to analyze whether PRRSV nsp1 and N protein could inhibit IFN-␤ production.	./cache/cord-267362-l4288mxw.txt	./txt/cord-267362-l4288mxw.txt