id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284866-66azyje4	D’ Andrea, Lucía	A detailed comparative analysis on the overall codon usage patterns in Hepatitis A virus	2011-02-04		.txt	text/plain	3854	190	52	The first axis in COA is highly correlated with the GC 3 S and GC 12 values in HAV ORFs. This result reveals that nucleotide composition plays an important key role in the codon usage bias observed in HAV ORFs (see Table 2 ). These observations indicate that the composition of dinucleotides also plays a key role in the variation found in synonymous codon usage among HAV ORFs. To study the possible effects of CpG under-representation on codon usage bias of HAV ORFs, the RSCU value of the eight codons that contain CpG (CCG, GCG, UCG, ACG, CGC, CGG, CGU, CGA) were analyzed. The results of these studies revealed that codon usage in HAV ORFs is quite different from that of human genes (see Table 1 ). Positions of the 30 HAV ORFs in the plot of the first two major axes by correspondence analysis (COA) of relative synonymous codon usage (RSCU) values.	./cache/cord-284866-66azyje4.txt	./txt/cord-284866-66azyje4.txt