id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285580-gq7400tq	Pieretti, Joana C.	Nitric oxide (NO) and nanoparticles – potential small tools for the war against COVID-19 and other human coronavirus infections	2020-10-18		.txt	text/plain	4877	281	49	In this mini-review, we discuss recent progress concerning the antivirus activity of NO in clinical, pre-clinical and research settings, and its beneficial effects in the treatment of clinical complications in patients infected with coronaviruses and other respiratory viral diseases, including COVID-19. Although positive biological effects have been reported for the administration of NO donors, further studies are required to better evaluate the levels of inflammatory mediators and the activity of important heme-containing enzymes, such as indoleamine 2,3-dioxygenase (IDO), directly involved in the inflammatory responses in respiratory viral infections (Anderson and Russel, 2020) . In other words, NO demonstrates potential for the treatment of patients infected with COVID-19 both in severe and nonsevere conditions, improving oxygenation and antiviral mechanisms, and preventing aggravation of the disease (Ferrari et al., 2020; Parikh et al., 2020) . Protocol of a randomized controlled trial testing inhaled nitric oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2)	./cache/cord-285580-gq7400tq.txt	./txt/cord-285580-gq7400tq.txt