id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290801-dv6aak01	Ivanyi-Nagy, Roland	Reprint of: Core protein-mediated 5′–3′ annealing of the West Nile virus genomic RNA in vitro()	2012-09-27		.txt	text/plain	6522	296	49	Since the core protein of flaviviruses is also endowed with potent RNA chaperone activities, we decided to examine the effect of West Nile virus (WNV) core on 5′–3′ genomic RNA annealing in vitro. These results indicate that core protein – besides its function in viral particle formation – might be involved in the regulation of flavivirus genomic RNA cyclization, and thus virus replication. In this study, we examined the effect of WNV core protein chaperoning on viral 5 -3 UTR annealing, using an in vitro model system with separate 5 and 3 RNAs. We found that core protein binding greatly increases the rate of 5 -3 complex formation, and is required for the interaction when full-length 3 UTR RNAs are used (Fig. 2) .	./cache/cord-290801-dv6aak01.txt	./txt/cord-290801-dv6aak01.txt