id author title date pages extension mime words sentences flesch summary cache txt cord-300883-rws11uel Padhi, Abinash Positive natural selection in the evolution of human metapneumovirus attachment glycoprotein 2007-10-10 .txt text/plain 3540 172 44 We also observed surprisingly higher nucleotide substitution rates per site, per year for each lineage of hMPV than the rates that were previously reported for the human respiratory syncytial virus, suggesting rapid evolutionary dynamics of hMPV. Although comparative genome mapping analyses suggested that this virus has structural and functional similarities with HRSV (Kahn, 2006) , recent studies reported that the attachment (G) glycoprotein of these paramimyxoviruses exhibit extensive nucleotide and amino acid variation, with most differences located in the extracellular domain (Peret et al., 2004; Kahn, 2006) . Here we used Yang et al's (2000) ML codon substitution models to test whether there was evidence at the nucleotide sequence level that a subset of amino acid sites in G-protein of hMPV sequences that represent each subgroup has been under positive selection. ./cache/cord-300883-rws11uel.txt ./txt/cord-300883-rws11uel.txt