id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304137-vxqkztio	Bueno, Carlos A.	A natural tetranortriterpenoid with immunomodulating properties as a potential anti-HSV agent	2009-01-20		.txt	text/plain	4722	227	50	We have reported that meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., exerts an antiviral action on the development of herpetic stromal keratitis (HSK) in mice by causing a significant decrease in the viral load in the eye of Herpes simplex virus type 1 (HSV-1) infected animals, as well as in the incidence and severity of lesions due to a virus-induced immunopathological reaction (Pifarré et al., 2002) . We have found that CDM is able to block HSV-1 induced activation of NF-B by inhibiting its translocation to the nucleus of infected human conjunctival cells (NHC), and postulated that CDM would be able to abolish murine HSK by controlling viral spread and the associated immunopathology as well (Barquero et al., 2006) . The aim of the present study was to determine whether CDM displays an antiviral activity in infected corneal cells, the target of HSV-1 multiplication in vivo, as well as its effect on the translocation of NF-B to the nucleus.	./cache/cord-304137-vxqkztio.txt	./txt/cord-304137-vxqkztio.txt