id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326349-59566vqe	Ding, Li	Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway	2013-12-26		.txt	text/plain	4890	233	58	In addition, TGEV infection of the cells synchronized in various stages of cell cycle showed that viral genomic RNA and subgenomic RNA, and virus titer were higher in the cells released from S-phaseor G2/M phase-synchronized cells than that in the cells released from the G0/G1 phase-synchronized or asynchronous cells after 18 h p.i. Taken together, our data suggested that TGEV infection induced S and G2/M phase arrest in host cells, which might provide a favorable condition for viral replication. To further determine the roles of p53 in TGEV-induced cell cycle arrest, we investigated the effects of PFT-␣, a specific inhibitor of p53 that does not affect the mRNA levels of TGEV genes (Huang et al., 2013) , on the cell cycle profiles and the expression of p21, cdks and cyclins in TGEV-infected PK-15 and ST cells. As shown in Fig. 6B , pre-incubation of PK-15 and ST cells with PFT-␣ attenuated cell cycle arrest at S and G2/M phase induced by TGEV infection.	./cache/cord-326349-59566vqe.txt	./txt/cord-326349-59566vqe.txt