id sid tid token lemma pos cord-256343-dtfw8o4g 1 1 key key JJ cord-256343-dtfw8o4g 1 2 : : : cord-256343-dtfw8o4g 1 3 cord-256343-dtfw8o4 cord-256343-dtfw8o4 NNP cord-256343-dtfw8o4g 1 4 g g NN cord-256343-dtfw8o4g 1 5 authors author NNS cord-256343-dtfw8o4g 1 6 : : : cord-256343-dtfw8o4g 1 7 Brandão Brandão NNP cord-256343-dtfw8o4g 1 8 , , , cord-256343-dtfw8o4g 1 9 Paulo Paulo NNP cord-256343-dtfw8o4g 1 10 Eduardo Eduardo NNP cord-256343-dtfw8o4g 2 1 title title NN cord-256343-dtfw8o4g 2 2 : : : cord-256343-dtfw8o4g 3 1 The the DT cord-256343-dtfw8o4g 3 2 evolution evolution NN cord-256343-dtfw8o4g 3 3 of of IN cord-256343-dtfw8o4g 3 4 codon codon NN cord-256343-dtfw8o4g 3 5 usage usage NN cord-256343-dtfw8o4g 3 6 in in IN cord-256343-dtfw8o4g 3 7 structural structural JJ cord-256343-dtfw8o4g 3 8 and and CC cord-256343-dtfw8o4g 3 9 non non JJ cord-256343-dtfw8o4g 3 10 - - JJ cord-256343-dtfw8o4g 3 11 structural structural JJ cord-256343-dtfw8o4g 3 12 viral viral JJ cord-256343-dtfw8o4g 3 13 genes gene NNS cord-256343-dtfw8o4g 3 14 : : : cord-256343-dtfw8o4g 3 15 The the DT cord-256343-dtfw8o4g 3 16 case case NN cord-256343-dtfw8o4g 3 17 of of IN cord-256343-dtfw8o4g 3 18 Avian avian JJ cord-256343-dtfw8o4g 3 19 coronavirus coronavirus NN cord-256343-dtfw8o4g 3 20 and and CC cord-256343-dtfw8o4g 3 21 its -PRON- PRP$ cord-256343-dtfw8o4g 3 22 natural natural JJ cord-256343-dtfw8o4g 3 23 host host NN cord-256343-dtfw8o4g 3 24 Gallus Gallus NNP cord-256343-dtfw8o4g 3 25 gallus gallus NN cord-256343-dtfw8o4g 3 26 date date NN cord-256343-dtfw8o4g 3 27 : : : cord-256343-dtfw8o4g 3 28 2013 2013 CD cord-256343-dtfw8o4g 3 29 - - SYM cord-256343-dtfw8o4g 3 30 12 12 CD cord-256343-dtfw8o4g 3 31 - - SYM cord-256343-dtfw8o4g 3 32 26 26 CD cord-256343-dtfw8o4g 3 33 journal journal NN cord-256343-dtfw8o4g 3 34 : : : cord-256343-dtfw8o4g 4 1 Virus virus NN cord-256343-dtfw8o4g 4 2 Res res NN cord-256343-dtfw8o4g 4 3 DOI doi NN cord-256343-dtfw8o4g 4 4 : : : cord-256343-dtfw8o4g 5 1 10.1016 10.1016 CD cord-256343-dtfw8o4g 5 2 / / SYM cord-256343-dtfw8o4g 5 3 j.virusres.2013.09.033 j.virusres.2013.09.033 NNP cord-256343-dtfw8o4g 5 4 sha sha NNP cord-256343-dtfw8o4g 5 5 : : : cord-256343-dtfw8o4g 6 1 3af802dbd78af066cc59bf0a894bb8ff128f06cc 3af802dbd78af066cc59bf0a894bb8ff128f06cc CD cord-256343-dtfw8o4g 6 2 doc_id doc_id CD cord-256343-dtfw8o4g 6 3 : : : cord-256343-dtfw8o4g 7 1 256343 256343 CD cord-256343-dtfw8o4g 7 2 cord_uid cord_uid NNS cord-256343-dtfw8o4g 7 3 : : : cord-256343-dtfw8o4g 7 4 dtfw8o4 dtfw8o4 NNP cord-256343-dtfw8o4g 7 5 g g NNP cord-256343-dtfw8o4g 8 1 To to TO cord-256343-dtfw8o4g 8 2 assess assess VB cord-256343-dtfw8o4g 8 3 the the DT cord-256343-dtfw8o4g 8 4 codon codon NN cord-256343-dtfw8o4g 8 5 evolution evolution NN cord-256343-dtfw8o4g 8 6 in in IN cord-256343-dtfw8o4g 8 7 virus virus NN cord-256343-dtfw8o4g 8 8 – – : cord-256343-dtfw8o4g 8 9 host host NN cord-256343-dtfw8o4g 8 10 systems system NNS cord-256343-dtfw8o4g 8 11 , , , cord-256343-dtfw8o4g 8 12 Avian avian JJ cord-256343-dtfw8o4g 8 13 coronavirus coronavirus NN cord-256343-dtfw8o4g 8 14 and and CC cord-256343-dtfw8o4g 8 15 its -PRON- PRP$ cord-256343-dtfw8o4g 8 16 natural natural JJ cord-256343-dtfw8o4g 8 17 host host NN cord-256343-dtfw8o4g 8 18 Gallus Gallus NNP cord-256343-dtfw8o4g 8 19 gallus gallus NN cord-256343-dtfw8o4g 8 20 were be VBD cord-256343-dtfw8o4g 8 21 used use VBN cord-256343-dtfw8o4g 8 22 as as IN cord-256343-dtfw8o4g 8 23 a a DT cord-256343-dtfw8o4g 8 24 model model NN cord-256343-dtfw8o4g 8 25 . . . cord-256343-dtfw8o4g 9 1 Codon codon NN cord-256343-dtfw8o4g 9 2 usage usage NN cord-256343-dtfw8o4g 9 3 ( ( -LRB- cord-256343-dtfw8o4g 9 4 CU CU NNP cord-256343-dtfw8o4g 9 5 ) ) -RRB- cord-256343-dtfw8o4g 9 6 was be VBD cord-256343-dtfw8o4g 9 7 measured measure VBN cord-256343-dtfw8o4g 9 8 for for IN cord-256343-dtfw8o4g 9 9 the the DT cord-256343-dtfw8o4g 9 10 viral viral JJ cord-256343-dtfw8o4g 9 11 spike spike NN cord-256343-dtfw8o4g 9 12 ( ( -LRB- cord-256343-dtfw8o4g 9 13 S S NNP cord-256343-dtfw8o4g 9 14 ) ) -RRB- cord-256343-dtfw8o4g 9 15 , , , cord-256343-dtfw8o4g 9 16 nucleocapsid nucleocapsid NN cord-256343-dtfw8o4g 9 17 ( ( -LRB- cord-256343-dtfw8o4g 9 18 N N NNP cord-256343-dtfw8o4g 9 19 ) ) -RRB- cord-256343-dtfw8o4g 9 20 , , , cord-256343-dtfw8o4g 9 21 nonstructural nonstructural JJ cord-256343-dtfw8o4g 9 22 protein protein NN cord-256343-dtfw8o4g 9 23 2 2 CD cord-256343-dtfw8o4g 9 24 ( ( -LRB- cord-256343-dtfw8o4g 9 25 NSP2 NSP2 NNP cord-256343-dtfw8o4g 9 26 ) ) -RRB- cord-256343-dtfw8o4g 9 27 and and CC cord-256343-dtfw8o4g 9 28 papain papain NN cord-256343-dtfw8o4g 9 29 - - HYPH cord-256343-dtfw8o4g 9 30 like like JJ cord-256343-dtfw8o4g 9 31 protease protease NN cord-256343-dtfw8o4g 9 32 ( ( -LRB- cord-256343-dtfw8o4g 9 33 PL(pro pl(pro ADD cord-256343-dtfw8o4g 9 34 ) ) -RRB- cord-256343-dtfw8o4g 9 35 ) ) -RRB- cord-256343-dtfw8o4g 9 36 genes gene NNS cord-256343-dtfw8o4g 9 37 from from IN cord-256343-dtfw8o4g 9 38 a a DT cord-256343-dtfw8o4g 9 39 diverse diverse JJ cord-256343-dtfw8o4g 9 40 set set NN cord-256343-dtfw8o4g 9 41 of of IN cord-256343-dtfw8o4g 9 42 A. a. NN cord-256343-dtfw8o4g 9 43 coronavirus coronavirus NN cord-256343-dtfw8o4g 9 44 lineages lineage NNS cord-256343-dtfw8o4g 9 45 and and CC cord-256343-dtfw8o4g 9 46 for for IN cord-256343-dtfw8o4g 9 47 G. G. NNP cord-256343-dtfw8o4g 9 48 gallus gallus NN cord-256343-dtfw8o4g 9 49 genes gene NNS cord-256343-dtfw8o4g 9 50 ( ( -LRB- cord-256343-dtfw8o4g 9 51 lung lung NN cord-256343-dtfw8o4g 9 52 surfactant surfactant NN cord-256343-dtfw8o4g 9 53 protein protein NN cord-256343-dtfw8o4g 9 54 A A NNP cord-256343-dtfw8o4g 9 55 , , , cord-256343-dtfw8o4g 9 56 intestinal intestinal JJ cord-256343-dtfw8o4g 9 57 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 9 58 , , , cord-256343-dtfw8o4g 9 59 oviduct oviduct NN cord-256343-dtfw8o4g 9 60 ovomucin ovomucin NNP cord-256343-dtfw8o4g 9 61 alpha alpha NNP cord-256343-dtfw8o4g 9 62 subunit subunit NN cord-256343-dtfw8o4g 9 63 , , , cord-256343-dtfw8o4g 9 64 kidney kidney NN cord-256343-dtfw8o4g 9 65 vitamin vitamin NN cord-256343-dtfw8o4g 9 66 D D NNP cord-256343-dtfw8o4g 9 67 receptor receptor NN cord-256343-dtfw8o4g 9 68 and and CC cord-256343-dtfw8o4g 9 69 the the DT cord-256343-dtfw8o4g 9 70 ubiquitary ubiquitary JJ cord-256343-dtfw8o4g 9 71 beta beta NN cord-256343-dtfw8o4g 9 72 - - HYPH cord-256343-dtfw8o4g 9 73 actin actin JJ cord-256343-dtfw8o4g 9 74 ) ) -RRB- cord-256343-dtfw8o4g 9 75 for for IN cord-256343-dtfw8o4g 9 76 different different JJ cord-256343-dtfw8o4g 9 77 A. a. NN cord-256343-dtfw8o4g 9 78 coronavirus coronavirus NN cord-256343-dtfw8o4g 9 79 replicating replicate VBG cord-256343-dtfw8o4g 9 80 sites site NNS cord-256343-dtfw8o4g 9 81 . . . cord-256343-dtfw8o4g 10 1 Relative relative JJ cord-256343-dtfw8o4g 10 2 synonymous synonymous JJ cord-256343-dtfw8o4g 10 3 codon codon NN cord-256343-dtfw8o4g 10 4 usage usage NN cord-256343-dtfw8o4g 10 5 ( ( -LRB- cord-256343-dtfw8o4g 10 6 RSCU RSCU NNP cord-256343-dtfw8o4g 10 7 ) ) -RRB- cord-256343-dtfw8o4g 10 8 trees tree NNS cord-256343-dtfw8o4g 10 9 accommodating accommodate VBG cord-256343-dtfw8o4g 10 10 all all DT cord-256343-dtfw8o4g 10 11 virus virus NN cord-256343-dtfw8o4g 10 12 and and CC cord-256343-dtfw8o4g 10 13 host host NN cord-256343-dtfw8o4g 10 14 genes gene NNS cord-256343-dtfw8o4g 10 15 in in IN cord-256343-dtfw8o4g 10 16 a a DT cord-256343-dtfw8o4g 10 17 single single JJ cord-256343-dtfw8o4g 10 18 topology topology NN cord-256343-dtfw8o4g 10 19 showed show VBD cord-256343-dtfw8o4g 10 20 a a DT cord-256343-dtfw8o4g 10 21 higher high JJR cord-256343-dtfw8o4g 10 22 proximity proximity NN cord-256343-dtfw8o4g 10 23 of of IN cord-256343-dtfw8o4g 10 24 A. a. NN cord-256343-dtfw8o4g 10 25 coronavirus coronavirus NN cord-256343-dtfw8o4g 10 26 CU CU NNP cord-256343-dtfw8o4g 10 27 to to IN cord-256343-dtfw8o4g 10 28 the the DT cord-256343-dtfw8o4g 10 29 respiratory respiratory JJ cord-256343-dtfw8o4g 10 30 tract tract NN cord-256343-dtfw8o4g 10 31 for for IN cord-256343-dtfw8o4g 10 32 all all DT cord-256343-dtfw8o4g 10 33 genes gene NNS cord-256343-dtfw8o4g 10 34 . . . cord-256343-dtfw8o4g 11 1 The the DT cord-256343-dtfw8o4g 11 2 codon codon NN cord-256343-dtfw8o4g 11 3 adaptation adaptation NN cord-256343-dtfw8o4g 11 4 index index NN cord-256343-dtfw8o4g 11 5 ( ( -LRB- cord-256343-dtfw8o4g 11 6 CAI CAI NNP cord-256343-dtfw8o4g 11 7 ) ) -RRB- cord-256343-dtfw8o4g 11 8 showed show VBD cord-256343-dtfw8o4g 11 9 a a DT cord-256343-dtfw8o4g 11 10 lower low JJR cord-256343-dtfw8o4g 11 11 adaptation adaptation NN cord-256343-dtfw8o4g 11 12 of of IN cord-256343-dtfw8o4g 11 13 S S NNP cord-256343-dtfw8o4g 11 14 to to IN cord-256343-dtfw8o4g 11 15 G. G. NNP cord-256343-dtfw8o4g 11 16 gallus gallus NN cord-256343-dtfw8o4g 11 17 compared compare VBN cord-256343-dtfw8o4g 11 18 to to IN cord-256343-dtfw8o4g 11 19 NSP2 NSP2 NNP cord-256343-dtfw8o4g 11 20 , , , cord-256343-dtfw8o4g 11 21 PL(pro pl(pro ADD cord-256343-dtfw8o4g 11 22 ) ) -RRB- cord-256343-dtfw8o4g 11 23 and and CC cord-256343-dtfw8o4g 11 24 N. n. NN cord-256343-dtfw8o4g 12 1 The the DT cord-256343-dtfw8o4g 12 2 effective effective JJ cord-256343-dtfw8o4g 12 3 number number NN cord-256343-dtfw8o4g 12 4 of of IN cord-256343-dtfw8o4g 12 5 codons codon NNS cord-256343-dtfw8o4g 12 6 ( ( -LRB- cord-256343-dtfw8o4g 12 7 Nc Nc NNP cord-256343-dtfw8o4g 12 8 ) ) -RRB- cord-256343-dtfw8o4g 12 9 and and CC cord-256343-dtfw8o4g 12 10 GC(3 GC(3 NNP cord-256343-dtfw8o4g 12 11 % % NN cord-256343-dtfw8o4g 12 12 ) ) -RRB- cord-256343-dtfw8o4g 12 13 revealed reveal VBD cord-256343-dtfw8o4g 12 14 that that IN cord-256343-dtfw8o4g 12 15 natural natural JJ cord-256343-dtfw8o4g 12 16 selection selection NN cord-256343-dtfw8o4g 12 17 and and CC cord-256343-dtfw8o4g 12 18 genetic genetic JJ cord-256343-dtfw8o4g 12 19 drift drift NN cord-256343-dtfw8o4g 12 20 are be VBP cord-256343-dtfw8o4g 12 21 the the DT cord-256343-dtfw8o4g 12 22 evolutionary evolutionary JJ cord-256343-dtfw8o4g 12 23 forces force NNS cord-256343-dtfw8o4g 12 24 driving drive VBG cord-256343-dtfw8o4g 12 25 the the DT cord-256343-dtfw8o4g 12 26 codon codon NN cord-256343-dtfw8o4g 12 27 usage usage NN cord-256343-dtfw8o4g 12 28 evolution evolution NN cord-256343-dtfw8o4g 12 29 of of IN cord-256343-dtfw8o4g 12 30 both both DT cord-256343-dtfw8o4g 12 31 A. a. NN cord-256343-dtfw8o4g 12 32 coronavirus coronavirus NN cord-256343-dtfw8o4g 12 33 and and CC cord-256343-dtfw8o4g 12 34 G. G. NNP cord-256343-dtfw8o4g 12 35 gallus gallus NN cord-256343-dtfw8o4g 12 36 regardless regardless RB cord-256343-dtfw8o4g 12 37 of of IN cord-256343-dtfw8o4g 12 38 the the DT cord-256343-dtfw8o4g 12 39 gene gene NN cord-256343-dtfw8o4g 12 40 being be VBG cord-256343-dtfw8o4g 12 41 considered consider VBN cord-256343-dtfw8o4g 12 42 . . . cord-256343-dtfw8o4g 13 1 The the DT cord-256343-dtfw8o4g 13 2 spike spike NN cord-256343-dtfw8o4g 13 3 gene gene NN cord-256343-dtfw8o4g 13 4 showed show VBD cord-256343-dtfw8o4g 13 5 only only RB cord-256343-dtfw8o4g 13 6 one one CD cord-256343-dtfw8o4g 13 7 100 100 CD cord-256343-dtfw8o4g 13 8 % % NN cord-256343-dtfw8o4g 13 9 conserved conserve VBN cord-256343-dtfw8o4g 13 10 amino amino NN cord-256343-dtfw8o4g 13 11 acid acid NN cord-256343-dtfw8o4g 13 12 position position NN cord-256343-dtfw8o4g 13 13 coded code VBN cord-256343-dtfw8o4g 13 14 by by IN cord-256343-dtfw8o4g 13 15 an an DT cord-256343-dtfw8o4g 13 16 A. a. NN cord-256343-dtfw8o4g 13 17 coronavirus coronavirus NN cord-256343-dtfw8o4g 13 18 preferred prefer VBN cord-256343-dtfw8o4g 13 19 codon codon NN cord-256343-dtfw8o4g 13 20 , , , cord-256343-dtfw8o4g 13 21 a a DT cord-256343-dtfw8o4g 13 22 significantly significantly RB cord-256343-dtfw8o4g 13 23 low low JJ cord-256343-dtfw8o4g 13 24 number number NN cord-256343-dtfw8o4g 13 25 when when WRB cord-256343-dtfw8o4g 13 26 compared compare VBN cord-256343-dtfw8o4g 13 27 to to IN cord-256343-dtfw8o4g 13 28 the the DT cord-256343-dtfw8o4g 13 29 three three CD cord-256343-dtfw8o4g 13 30 other other JJ cord-256343-dtfw8o4g 13 31 genes gene NNS cord-256343-dtfw8o4g 13 32 ( ( -LRB- cord-256343-dtfw8o4g 13 33 p p NN cord-256343-dtfw8o4g 13 34 < < XX cord-256343-dtfw8o4g 13 35 0.0001 0.0001 CD cord-256343-dtfw8o4g 13 36 ) ) -RRB- cord-256343-dtfw8o4g 13 37 . . . cord-256343-dtfw8o4g 14 1 Virus Virus NNP cord-256343-dtfw8o4g 14 2 CU CU NNP cord-256343-dtfw8o4g 14 3 evolves evolve VBZ cord-256343-dtfw8o4g 14 4 independently independently RB cord-256343-dtfw8o4g 14 5 for for IN cord-256343-dtfw8o4g 14 6 each each DT cord-256343-dtfw8o4g 14 7 gene gene NN cord-256343-dtfw8o4g 14 8 in in IN cord-256343-dtfw8o4g 14 9 a a DT cord-256343-dtfw8o4g 14 10 manner manner NN cord-256343-dtfw8o4g 14 11 predicted predict VBN cord-256343-dtfw8o4g 14 12 by by IN cord-256343-dtfw8o4g 14 13 the the DT cord-256343-dtfw8o4g 14 14 protein protein NN cord-256343-dtfw8o4g 14 15 function function NN cord-256343-dtfw8o4g 14 16 , , , cord-256343-dtfw8o4g 14 17 with with IN cord-256343-dtfw8o4g 14 18 a a DT cord-256343-dtfw8o4g 14 19 balance balance NN cord-256343-dtfw8o4g 14 20 between between IN cord-256343-dtfw8o4g 14 21 natural natural JJ cord-256343-dtfw8o4g 14 22 selection selection NN cord-256343-dtfw8o4g 14 23 and and CC cord-256343-dtfw8o4g 14 24 mutation mutation NN cord-256343-dtfw8o4g 14 25 pressure pressure NN cord-256343-dtfw8o4g 14 26 , , , cord-256343-dtfw8o4g 14 27 giving give VBG cord-256343-dtfw8o4g 14 28 further further JJ cord-256343-dtfw8o4g 14 29 molecular molecular JJ cord-256343-dtfw8o4g 14 30 basis basis NN cord-256343-dtfw8o4g 14 31 for for IN cord-256343-dtfw8o4g 14 32 the the DT cord-256343-dtfw8o4g 14 33 viruses virus NNS cord-256343-dtfw8o4g 14 34 ’ ’ POS cord-256343-dtfw8o4g 14 35 ability ability NN cord-256343-dtfw8o4g 14 36 to to TO cord-256343-dtfw8o4g 14 37 exploit exploit VB cord-256343-dtfw8o4g 14 38 the the DT cord-256343-dtfw8o4g 14 39 host host NN cord-256343-dtfw8o4g 14 40 's 's POS cord-256343-dtfw8o4g 14 41 cellular cellular JJ cord-256343-dtfw8o4g 14 42 environment environment NN cord-256343-dtfw8o4g 14 43 in in IN cord-256343-dtfw8o4g 14 44 a a DT cord-256343-dtfw8o4g 14 45 concerted concerted JJ cord-256343-dtfw8o4g 14 46 virus virus NN cord-256343-dtfw8o4g 14 47 – – : cord-256343-dtfw8o4g 14 48 host host NN cord-256343-dtfw8o4g 14 49 molecular molecular JJ cord-256343-dtfw8o4g 14 50 evolution evolution NN cord-256343-dtfw8o4g 14 51 . . . cord-256343-dtfw8o4g 15 1 Codon codon NN cord-256343-dtfw8o4g 15 2 usage usage NN cord-256343-dtfw8o4g 15 3 ( ( -LRB- cord-256343-dtfw8o4g 15 4 CU CU NNP cord-256343-dtfw8o4g 15 5 ) ) -RRB- cord-256343-dtfw8o4g 15 6 refers refer VBZ cord-256343-dtfw8o4g 15 7 to to IN cord-256343-dtfw8o4g 15 8 the the DT cord-256343-dtfw8o4g 15 9 frequency frequency NN cord-256343-dtfw8o4g 15 10 of of IN cord-256343-dtfw8o4g 15 11 the the DT cord-256343-dtfw8o4g 15 12 occurrence occurrence NN cord-256343-dtfw8o4g 15 13 of of IN cord-256343-dtfw8o4g 15 14 each each DT cord-256343-dtfw8o4g 15 15 codon codon NN cord-256343-dtfw8o4g 15 16 for for IN cord-256343-dtfw8o4g 15 17 at at RB cord-256343-dtfw8o4g 15 18 least least RBS cord-256343-dtfw8o4g 15 19 two two CD cord-256343-dtfw8o4g 15 20 - - HYPH cord-256343-dtfw8o4g 15 21 fold fold JJ cord-256343-dtfw8o4g 15 22 degenerate degenerate JJ cord-256343-dtfw8o4g 15 23 codons codon NNS cord-256343-dtfw8o4g 15 24 ( ( -LRB- cord-256343-dtfw8o4g 15 25 Hershberg Hershberg NNP cord-256343-dtfw8o4g 15 26 and and CC cord-256343-dtfw8o4g 15 27 Petrov Petrov NNP cord-256343-dtfw8o4g 15 28 , , , cord-256343-dtfw8o4g 15 29 2008 2008 CD cord-256343-dtfw8o4g 15 30 ) ) -RRB- cord-256343-dtfw8o4g 15 31 , , , cord-256343-dtfw8o4g 15 32 i.e. i.e. FW cord-256343-dtfw8o4g 15 33 , , , cord-256343-dtfw8o4g 15 34 it -PRON- PRP cord-256343-dtfw8o4g 15 35 is be VBZ cord-256343-dtfw8o4g 15 36 an an DT cord-256343-dtfw8o4g 15 37 indication indication NN cord-256343-dtfw8o4g 15 38 of of IN cord-256343-dtfw8o4g 15 39 the the DT cord-256343-dtfw8o4g 15 40 ' ' `` cord-256343-dtfw8o4g 15 41 preference preference NN cord-256343-dtfw8o4g 15 42 ' ' '' cord-256343-dtfw8o4g 15 43 of of IN cord-256343-dtfw8o4g 15 44 a a DT cord-256343-dtfw8o4g 15 45 genome genome NN cord-256343-dtfw8o4g 15 46 for for IN cord-256343-dtfw8o4g 15 47 one one CD cord-256343-dtfw8o4g 15 48 or or CC cord-256343-dtfw8o4g 15 49 more more JJR cord-256343-dtfw8o4g 15 50 codons codon NNS cord-256343-dtfw8o4g 15 51 if if IN cord-256343-dtfw8o4g 15 52 more more JJR cord-256343-dtfw8o4g 15 53 than than IN cord-256343-dtfw8o4g 15 54 one one CD cord-256343-dtfw8o4g 15 55 codon codon NN cord-256343-dtfw8o4g 15 56 is be VBZ cord-256343-dtfw8o4g 15 57 possible possible JJ cord-256343-dtfw8o4g 15 58 for for IN cord-256343-dtfw8o4g 15 59 the the DT cord-256343-dtfw8o4g 15 60 same same JJ cord-256343-dtfw8o4g 15 61 amino amino NN cord-256343-dtfw8o4g 15 62 acid acid NN cord-256343-dtfw8o4g 15 63 . . . cord-256343-dtfw8o4g 16 1 Natural natural JJ cord-256343-dtfw8o4g 16 2 selection selection NN cord-256343-dtfw8o4g 16 3 for for IN cord-256343-dtfw8o4g 16 4 efficient efficient JJ cord-256343-dtfw8o4g 16 5 protein protein NN cord-256343-dtfw8o4g 16 6 synthesis synthesis NN cord-256343-dtfw8o4g 16 7 speed speed NN cord-256343-dtfw8o4g 16 8 and and CC cord-256343-dtfw8o4g 16 9 folding folding NN cord-256343-dtfw8o4g 16 10 and and CC cord-256343-dtfw8o4g 16 11 genetic genetic JJ cord-256343-dtfw8o4g 16 12 drift drift NN cord-256343-dtfw8o4g 16 13 based base VBN cord-256343-dtfw8o4g 16 14 on on IN cord-256343-dtfw8o4g 16 15 mutation mutation NN cord-256343-dtfw8o4g 16 16 pressure pressure NN cord-256343-dtfw8o4g 16 17 that that WDT cord-256343-dtfw8o4g 16 18 leads lead VBZ cord-256343-dtfw8o4g 16 19 to to IN cord-256343-dtfw8o4g 16 20 a a DT cord-256343-dtfw8o4g 16 21 homogeneous homogeneous JJ cord-256343-dtfw8o4g 16 22 genome genome NN cord-256343-dtfw8o4g 16 23 and and CC cord-256343-dtfw8o4g 16 24 the the DT cord-256343-dtfw8o4g 16 25 3rd 3rd JJ cord-256343-dtfw8o4g 16 26 codon codon NN cord-256343-dtfw8o4g 16 27 's 's POS cord-256343-dtfw8o4g 16 28 GC%s GC%s NNP cord-256343-dtfw8o4g 16 29 are be VBP cord-256343-dtfw8o4g 16 30 the the DT cord-256343-dtfw8o4g 16 31 most most RBS cord-256343-dtfw8o4g 16 32 evident evident JJ cord-256343-dtfw8o4g 16 33 forces force NNS cord-256343-dtfw8o4g 16 34 under under IN cord-256343-dtfw8o4g 16 35 codon codon NN cord-256343-dtfw8o4g 16 36 usage usage NN cord-256343-dtfw8o4g 16 37 evolution evolution NN cord-256343-dtfw8o4g 16 38 that that WDT cord-256343-dtfw8o4g 16 39 could could MD cord-256343-dtfw8o4g 16 40 lead lead VB cord-256343-dtfw8o4g 16 41 to to IN cord-256343-dtfw8o4g 16 42 detectable detectable JJ cord-256343-dtfw8o4g 16 43 codon codon NN cord-256343-dtfw8o4g 16 44 usage usage NN cord-256343-dtfw8o4g 16 45 bias bias NN cord-256343-dtfw8o4g 16 46 ( ( -LRB- cord-256343-dtfw8o4g 16 47 CUB cub NN cord-256343-dtfw8o4g 16 48 ) ) -RRB- cord-256343-dtfw8o4g 16 49 ( ( -LRB- cord-256343-dtfw8o4g 16 50 Yang Yang NNP cord-256343-dtfw8o4g 16 51 and and CC cord-256343-dtfw8o4g 16 52 Nielsen Nielsen NNP cord-256343-dtfw8o4g 16 53 , , , cord-256343-dtfw8o4g 16 54 2008 2008 CD cord-256343-dtfw8o4g 16 55 ) ) -RRB- cord-256343-dtfw8o4g 16 56 , , , cord-256343-dtfw8o4g 16 57 which which WDT cord-256343-dtfw8o4g 16 58 has have VBZ cord-256343-dtfw8o4g 16 59 been be VBN cord-256343-dtfw8o4g 16 60 increasingly increasingly RB cord-256343-dtfw8o4g 16 61 used use VBN cord-256343-dtfw8o4g 16 62 in in IN cord-256343-dtfw8o4g 16 63 studies study NNS cord-256343-dtfw8o4g 16 64 on on IN cord-256343-dtfw8o4g 16 65 virus virus NN cord-256343-dtfw8o4g 16 66 and and CC cord-256343-dtfw8o4g 16 67 host host NN cord-256343-dtfw8o4g 16 68 molecular molecular JJ cord-256343-dtfw8o4g 16 69 evolution evolution NN cord-256343-dtfw8o4g 16 70 . . . cord-256343-dtfw8o4g 17 1 Avian avian JJ cord-256343-dtfw8o4g 17 2 coronavirus coronavirus NN cord-256343-dtfw8o4g 17 3 ( ( -LRB- cord-256343-dtfw8o4g 17 4 Nidovirales nidovirale NNS cord-256343-dtfw8o4g 17 5 : : : cord-256343-dtfw8o4g 17 6 Coronaviridae Coronaviridae NNP cord-256343-dtfw8o4g 17 7 : : : cord-256343-dtfw8o4g 17 8 Coronavirinae Coronavirinae NNP cord-256343-dtfw8o4g 17 9 : : : cord-256343-dtfw8o4g 17 10 Gammacoronavirus Gammacoronavirus NNP cord-256343-dtfw8o4g 17 11 ) ) -RRB- cord-256343-dtfw8o4g 17 12 , , , cord-256343-dtfw8o4g 17 13 which which WDT cord-256343-dtfw8o4g 17 14 originated originate VBD cord-256343-dtfw8o4g 17 15 approximately approximately RB cord-256343-dtfw8o4g 17 16 4800 4800 CD cord-256343-dtfw8o4g 17 17 years year NNS cord-256343-dtfw8o4g 17 18 ago ago RB cord-256343-dtfw8o4g 18 1 ( ( -LRB- cord-256343-dtfw8o4g 18 2 Woo woo UH cord-256343-dtfw8o4g 18 3 et et FW cord-256343-dtfw8o4g 18 4 al al NNP cord-256343-dtfw8o4g 18 5 . . NNP cord-256343-dtfw8o4g 18 6 , , , cord-256343-dtfw8o4g 18 7 2012 2012 CD cord-256343-dtfw8o4g 18 8 ) ) -RRB- cord-256343-dtfw8o4g 18 9 and and CC cord-256343-dtfw8o4g 18 10 has have VBZ cord-256343-dtfw8o4g 18 11 a a DT cord-256343-dtfw8o4g 18 12 large large JJ cord-256343-dtfw8o4g 18 13 number number NN cord-256343-dtfw8o4g 18 14 of of IN cord-256343-dtfw8o4g 18 15 serotypes serotype NNS cord-256343-dtfw8o4g 18 16 and and CC cord-256343-dtfw8o4g 18 17 genotypes genotype NNS cord-256343-dtfw8o4g 18 18 , , , cord-256343-dtfw8o4g 18 19 primarily primarily RB cord-256343-dtfw8o4g 18 20 infects infect VBZ cord-256343-dtfw8o4g 18 21 the the DT cord-256343-dtfw8o4g 18 22 respiratory respiratory JJ cord-256343-dtfw8o4g 18 23 tract tract NN cord-256343-dtfw8o4g 18 24 of of IN cord-256343-dtfw8o4g 18 25 laying lay VBG cord-256343-dtfw8o4g 18 26 hens hen NNS cord-256343-dtfw8o4g 18 27 , , , cord-256343-dtfw8o4g 18 28 broilers broiler NNS cord-256343-dtfw8o4g 18 29 and and CC cord-256343-dtfw8o4g 18 30 breeders breeder NNS cord-256343-dtfw8o4g 18 31 but but CC cord-256343-dtfw8o4g 18 32 can can MD cord-256343-dtfw8o4g 18 33 also also RB cord-256343-dtfw8o4g 18 34 infect infect VB cord-256343-dtfw8o4g 18 35 the the DT cord-256343-dtfw8o4g 18 36 kidneys kidney NNS cord-256343-dtfw8o4g 18 37 , , , cord-256343-dtfw8o4g 18 38 intestines intestine NNS cord-256343-dtfw8o4g 18 39 and and CC cord-256343-dtfw8o4g 18 40 reproductive reproductive JJ cord-256343-dtfw8o4g 18 41 tracts tract NNS cord-256343-dtfw8o4g 18 42 of of IN cord-256343-dtfw8o4g 18 43 both both DT cord-256343-dtfw8o4g 18 44 females female NNS cord-256343-dtfw8o4g 18 45 and and CC cord-256343-dtfw8o4g 18 46 males male NNS cord-256343-dtfw8o4g 18 47 ( ( -LRB- cord-256343-dtfw8o4g 18 48 Cook Cook NNP cord-256343-dtfw8o4g 18 49 et et NNP cord-256343-dtfw8o4g 18 50 al al NNP cord-256343-dtfw8o4g 18 51 . . . cord-256343-dtfw8o4g 19 1 , , , cord-256343-dtfw8o4g 19 2 E e NN cord-256343-dtfw8o4g 19 3 - - NN cord-256343-dtfw8o4g 19 4 mail mail NN cord-256343-dtfw8o4g 19 5 address address NN cord-256343-dtfw8o4g 19 6 : : : cord-256343-dtfw8o4g 19 7 paulo7926@usp.br paulo7926@usp.br NNP cord-256343-dtfw8o4g 19 8 2012 2012 CD cord-256343-dtfw8o4g 19 9 ) ) -RRB- cord-256343-dtfw8o4g 19 10 , , , cord-256343-dtfw8o4g 19 11 depending depend VBG cord-256343-dtfw8o4g 19 12 on on IN cord-256343-dtfw8o4g 19 13 the the DT cord-256343-dtfw8o4g 19 14 pathotype pathotype NN cord-256343-dtfw8o4g 19 15 . . . cord-256343-dtfw8o4g 20 1 Though though IN cord-256343-dtfw8o4g 20 2 affinity affinity NN cord-256343-dtfw8o4g 20 3 to to IN cord-256343-dtfw8o4g 20 4 different different JJ cord-256343-dtfw8o4g 20 5 classes class NNS cord-256343-dtfw8o4g 20 6 of of IN cord-256343-dtfw8o4g 20 7 cell cell NN cord-256343-dtfw8o4g 20 8 membrane membrane NN cord-256343-dtfw8o4g 20 9 glycans glycan NNS cord-256343-dtfw8o4g 20 10 could could MD cord-256343-dtfw8o4g 20 11 be be VB cord-256343-dtfw8o4g 20 12 one one CD cord-256343-dtfw8o4g 20 13 of of IN cord-256343-dtfw8o4g 20 14 the the DT cord-256343-dtfw8o4g 20 15 explanations explanation NNS cord-256343-dtfw8o4g 20 16 for for IN cord-256343-dtfw8o4g 20 17 the the DT cord-256343-dtfw8o4g 20 18 existence existence NN cord-256343-dtfw8o4g 20 19 of of IN cord-256343-dtfw8o4g 20 20 the the DT cord-256343-dtfw8o4g 20 21 different different JJ cord-256343-dtfw8o4g 20 22 viral viral JJ cord-256343-dtfw8o4g 20 23 pathotypes pathotypes NN cord-256343-dtfw8o4g 20 24 ( ( -LRB- cord-256343-dtfw8o4g 20 25 Wickramasinghe Wickramasinghe NNP cord-256343-dtfw8o4g 20 26 et et NNP cord-256343-dtfw8o4g 20 27 al al NNP cord-256343-dtfw8o4g 20 28 . . NNP cord-256343-dtfw8o4g 20 29 , , , cord-256343-dtfw8o4g 20 30 2011 2011 CD cord-256343-dtfw8o4g 20 31 ) ) -RRB- cord-256343-dtfw8o4g 20 32 , , , cord-256343-dtfw8o4g 20 33 the the DT cord-256343-dtfw8o4g 20 34 exact exact JJ cord-256343-dtfw8o4g 20 35 mechanism mechanism NN cord-256343-dtfw8o4g 20 36 for for IN cord-256343-dtfw8o4g 20 37 this this DT cord-256343-dtfw8o4g 20 38 level level NN cord-256343-dtfw8o4g 20 39 of of IN cord-256343-dtfw8o4g 20 40 diversity diversity NN cord-256343-dtfw8o4g 20 41 is be VBZ cord-256343-dtfw8o4g 20 42 still still RB cord-256343-dtfw8o4g 20 43 unknown unknown JJ cord-256343-dtfw8o4g 20 44 . . . cord-256343-dtfw8o4g 21 1 The the DT cord-256343-dtfw8o4g 21 2 27.6 27.6 CD cord-256343-dtfw8o4g 21 3 kb kb NNP cord-256343-dtfw8o4g 21 4 single single RB cord-256343-dtfw8o4g 21 5 - - HYPH cord-256343-dtfw8o4g 21 6 stranded strand VBN cord-256343-dtfw8o4g 21 7 positive positive JJ cord-256343-dtfw8o4g 21 8 sense sense NN cord-256343-dtfw8o4g 21 9 RNA RNA NNP cord-256343-dtfw8o4g 21 10 of of IN cord-256343-dtfw8o4g 21 11 A. a. NN cord-256343-dtfw8o4g 21 12 coronavirus coronavirus NN cord-256343-dtfw8o4g 21 13 encodes encode VBZ cord-256343-dtfw8o4g 21 14 23 23 CD cord-256343-dtfw8o4g 21 15 proteins protein NNS cord-256343-dtfw8o4g 21 16 , , , cord-256343-dtfw8o4g 21 17 and and CC cord-256343-dtfw8o4g 21 18 the the DT cord-256343-dtfw8o4g 21 19 first first JJ cord-256343-dtfw8o4g 21 20 two two CD cord-256343-dtfw8o4g 21 21 - - HYPH cord-256343-dtfw8o4g 21 22 thirds third NNS cord-256343-dtfw8o4g 21 23 of of IN cord-256343-dtfw8o4g 21 24 the the DT cord-256343-dtfw8o4g 21 25 genome genome NN cord-256343-dtfw8o4g 21 26 contains contain VBZ cord-256343-dtfw8o4g 21 27 ORF ORF NNP cord-256343-dtfw8o4g 21 28 1 1 CD cord-256343-dtfw8o4g 21 29 , , , cord-256343-dtfw8o4g 21 30 which which WDT cord-256343-dtfw8o4g 21 31 encodes encode VBZ cord-256343-dtfw8o4g 21 32 15 15 CD cord-256343-dtfw8o4g 21 33 non non JJ cord-256343-dtfw8o4g 21 34 - - JJ cord-256343-dtfw8o4g 21 35 structural structural JJ cord-256343-dtfw8o4g 21 36 proteins protein NNS cord-256343-dtfw8o4g 21 37 involved involve VBN cord-256343-dtfw8o4g 21 38 in in IN cord-256343-dtfw8o4g 21 39 RNA RNA NNP cord-256343-dtfw8o4g 21 40 transcription transcription NN cord-256343-dtfw8o4g 21 41 and and CC cord-256343-dtfw8o4g 21 42 replication replication NN cord-256343-dtfw8o4g 21 43 ( ( -LRB- cord-256343-dtfw8o4g 21 44 Masters Masters NNP cord-256343-dtfw8o4g 21 45 , , , cord-256343-dtfw8o4g 21 46 2006 2006 CD cord-256343-dtfw8o4g 21 47 ; ; : cord-256343-dtfw8o4g 21 48 Ziebuhr Ziebuhr NNP cord-256343-dtfw8o4g 21 49 and and CC cord-256343-dtfw8o4g 21 50 Snijder Snijder NNP cord-256343-dtfw8o4g 21 51 , , , cord-256343-dtfw8o4g 21 52 2007 2007 CD cord-256343-dtfw8o4g 21 53 ) ) -RRB- cord-256343-dtfw8o4g 21 54 . . . cord-256343-dtfw8o4g 22 1 Among among IN cord-256343-dtfw8o4g 22 2 these these DT cord-256343-dtfw8o4g 22 3 , , , cord-256343-dtfw8o4g 22 4 the the DT cord-256343-dtfw8o4g 22 5 papain papain NN cord-256343-dtfw8o4g 22 6 - - HYPH cord-256343-dtfw8o4g 22 7 like like JJ cord-256343-dtfw8o4g 22 8 protease protease NN cord-256343-dtfw8o4g 22 9 ( ( -LRB- cord-256343-dtfw8o4g 22 10 PL pl NN cord-256343-dtfw8o4g 22 11 pro pro FW cord-256343-dtfw8o4g 22 12 ) ) -RRB- cord-256343-dtfw8o4g 22 13 is be VBZ cord-256343-dtfw8o4g 22 14 the the DT cord-256343-dtfw8o4g 22 15 proteolytic proteolytic JJ cord-256343-dtfw8o4g 22 16 processor processor NN cord-256343-dtfw8o4g 22 17 of of IN cord-256343-dtfw8o4g 22 18 the the DT cord-256343-dtfw8o4g 22 19 N n CD cord-256343-dtfw8o4g 22 20 - - HYPH cord-256343-dtfw8o4g 22 21 proximal proximal JJ cord-256343-dtfw8o4g 22 22 domain domain NN cord-256343-dtfw8o4g 22 23 of of IN cord-256343-dtfw8o4g 23 1 polyproteins polyproteins NNP cord-256343-dtfw8o4g 23 2 pp1a pp1a NNP cord-256343-dtfw8o4g 23 3 and and CC cord-256343-dtfw8o4g 23 4 pp1ab pp1ab NNP cord-256343-dtfw8o4g 23 5 ( ( -LRB- cord-256343-dtfw8o4g 23 6 Ziebuhr Ziebuhr NNP cord-256343-dtfw8o4g 23 7 et et NNP cord-256343-dtfw8o4g 23 8 al al NNP cord-256343-dtfw8o4g 23 9 . . NNP cord-256343-dtfw8o4g 23 10 , , , cord-256343-dtfw8o4g 23 11 2000 2000 CD cord-256343-dtfw8o4g 23 12 ) ) -RRB- cord-256343-dtfw8o4g 23 13 . . . cord-256343-dtfw8o4g 24 1 Non non JJ cord-256343-dtfw8o4g 24 2 - - JJ cord-256343-dtfw8o4g 24 3 structural structural JJ cord-256343-dtfw8o4g 24 4 protein protein NN cord-256343-dtfw8o4g 24 5 2 2 CD cord-256343-dtfw8o4g 24 6 ( ( -LRB- cord-256343-dtfw8o4g 24 7 NSP2 NSP2 NNP cord-256343-dtfw8o4g 24 8 ) ) -RRB- cord-256343-dtfw8o4g 24 9 , , , cord-256343-dtfw8o4g 24 10 the the DT cord-256343-dtfw8o4g 24 11 first first JJ cord-256343-dtfw8o4g 24 12 in in IN cord-256343-dtfw8o4g 24 13 ORF ORF NNP cord-256343-dtfw8o4g 24 14 1 1 CD cord-256343-dtfw8o4g 24 15 because because IN cord-256343-dtfw8o4g 24 16 the the DT cord-256343-dtfw8o4g 24 17 A. a. NN cord-256343-dtfw8o4g 24 18 coronavirus coronavirus NN cord-256343-dtfw8o4g 24 19 lacks lack VBZ cord-256343-dtfw8o4g 24 20 NSP1 NSP1 NNP cord-256343-dtfw8o4g 24 21 , , , cord-256343-dtfw8o4g 24 22 has have VBZ cord-256343-dtfw8o4g 24 23 a a DT cord-256343-dtfw8o4g 24 24 still still RB cord-256343-dtfw8o4g 24 25 undefined undefined JJ cord-256343-dtfw8o4g 24 26 role role NN cord-256343-dtfw8o4g 24 27 , , , cord-256343-dtfw8o4g 24 28 though though IN cord-256343-dtfw8o4g 24 29 a a DT cord-256343-dtfw8o4g 24 30 role role NN cord-256343-dtfw8o4g 24 31 on on IN cord-256343-dtfw8o4g 24 32 global global JJ cord-256343-dtfw8o4g 24 33 RNA RNA NNP cord-256343-dtfw8o4g 24 34 synthesis synthesis NN cord-256343-dtfw8o4g 24 35 has have VBZ cord-256343-dtfw8o4g 24 36 been be VBN cord-256343-dtfw8o4g 24 37 suggested suggest VBN cord-256343-dtfw8o4g 24 38 ( ( -LRB- cord-256343-dtfw8o4g 24 39 Graham Graham NNP cord-256343-dtfw8o4g 24 40 et et NNP cord-256343-dtfw8o4g 24 41 al al NNP cord-256343-dtfw8o4g 24 42 . . NNP cord-256343-dtfw8o4g 24 43 , , , cord-256343-dtfw8o4g 24 44 2005 2005 CD cord-256343-dtfw8o4g 24 45 ) ) -RRB- cord-256343-dtfw8o4g 24 46 . . . cord-256343-dtfw8o4g 25 1 Of of IN cord-256343-dtfw8o4g 25 2 the the DT cord-256343-dtfw8o4g 25 3 structural structural JJ cord-256343-dtfw8o4g 25 4 proteins protein NNS cord-256343-dtfw8o4g 25 5 , , , cord-256343-dtfw8o4g 25 6 the the DT cord-256343-dtfw8o4g 25 7 spike spike NN cord-256343-dtfw8o4g 25 8 glycoprotein glycoprotein NN cord-256343-dtfw8o4g 25 9 ( ( -LRB- cord-256343-dtfw8o4g 25 10 S S NNP cord-256343-dtfw8o4g 25 11 ) ) -RRB- cord-256343-dtfw8o4g 25 12 has have VBZ cord-256343-dtfw8o4g 25 13 a a DT cord-256343-dtfw8o4g 25 14 strong strong JJ cord-256343-dtfw8o4g 25 15 interaction interaction NN cord-256343-dtfw8o4g 25 16 with with IN cord-256343-dtfw8o4g 25 17 the the DT cord-256343-dtfw8o4g 25 18 host host NN cord-256343-dtfw8o4g 25 19 immune immune JJ cord-256343-dtfw8o4g 25 20 system system NN cord-256343-dtfw8o4g 25 21 and and CC cord-256343-dtfw8o4g 25 22 is be VBZ cord-256343-dtfw8o4g 25 23 so so RB cord-256343-dtfw8o4g 25 24 highly highly RB cord-256343-dtfw8o4g 25 25 polymorphic polymorphic JJ cord-256343-dtfw8o4g 25 26 that that IN cord-256343-dtfw8o4g 25 27 mutations mutation NNS cord-256343-dtfw8o4g 25 28 in in IN cord-256343-dtfw8o4g 25 29 only only RB cord-256343-dtfw8o4g 25 30 10 10 CD cord-256343-dtfw8o4g 25 31 amino amino NN cord-256343-dtfw8o4g 25 32 acids acid NNS cord-256343-dtfw8o4g 25 33 on on IN cord-256343-dtfw8o4g 25 34 the the DT cord-256343-dtfw8o4g 25 35 amino amino NN cord-256343-dtfw8o4g 25 36 terminal terminal NN cord-256343-dtfw8o4g 25 37 ectodomain ectodomain NN cord-256343-dtfw8o4g 25 38 ( ( -LRB- cord-256343-dtfw8o4g 25 39 S1 S1 NNP cord-256343-dtfw8o4g 25 40 ) ) -RRB- cord-256343-dtfw8o4g 25 41 could could MD cord-256343-dtfw8o4g 25 42 result result VB cord-256343-dtfw8o4g 25 43 in in IN cord-256343-dtfw8o4g 25 44 the the DT cord-256343-dtfw8o4g 25 45 loss loss NN cord-256343-dtfw8o4g 25 46 of of IN cord-256343-dtfw8o4g 25 47 cross cross NN cord-256343-dtfw8o4g 25 48 - - NN cord-256343-dtfw8o4g 25 49 reactivity reactivity JJ cord-256343-dtfw8o4g 25 50 ( ( -LRB- cord-256343-dtfw8o4g 25 51 Cavanagh Cavanagh NNP cord-256343-dtfw8o4g 25 52 , , , cord-256343-dtfw8o4g 25 53 2007 2007 CD cord-256343-dtfw8o4g 25 54 ) ) -RRB- cord-256343-dtfw8o4g 25 55 . . . cord-256343-dtfw8o4g 26 1 While while IN cord-256343-dtfw8o4g 26 2 S1 s1 NN cord-256343-dtfw8o4g 26 3 allows allow VBZ cord-256343-dtfw8o4g 26 4 the the DT cord-256343-dtfw8o4g 26 5 virus virus NN cord-256343-dtfw8o4g 26 6 to to TO cord-256343-dtfw8o4g 26 7 attach attach VB cord-256343-dtfw8o4g 26 8 to to IN cord-256343-dtfw8o4g 26 9 ␣ ␣ NNP cord-256343-dtfw8o4g 26 10 2,3Sia 2,3sia CD cord-256343-dtfw8o4g 26 11 , , , cord-256343-dtfw8o4g 26 12 which which WDT cord-256343-dtfw8o4g 26 13 is be VBZ cord-256343-dtfw8o4g 26 14 widespread widespread JJ cord-256343-dtfw8o4g 26 15 in in IN cord-256343-dtfw8o4g 26 16 chicken chicken NN cord-256343-dtfw8o4g 26 17 cells cell NNS cord-256343-dtfw8o4g 26 18 ( ( -LRB- cord-256343-dtfw8o4g 26 19 Winter Winter NNP cord-256343-dtfw8o4g 26 20 et et NNP cord-256343-dtfw8o4g 26 21 al al NNP cord-256343-dtfw8o4g 26 22 . . NNP cord-256343-dtfw8o4g 26 23 , , , cord-256343-dtfw8o4g 26 24 2008 2008 CD cord-256343-dtfw8o4g 26 25 ) ) -RRB- cord-256343-dtfw8o4g 26 26 , , , cord-256343-dtfw8o4g 26 27 the the DT cord-256343-dtfw8o4g 26 28 carboxy carboxy JJ cord-256343-dtfw8o4g 26 29 terminal terminal NN cord-256343-dtfw8o4g 26 30 S2 S2 NNP cord-256343-dtfw8o4g 26 31 has have VBZ cord-256343-dtfw8o4g 26 32 the the DT cord-256343-dtfw8o4g 26 33 capacity capacity NN cord-256343-dtfw8o4g 26 34 to to TO cord-256343-dtfw8o4g 26 35 fuse fuse VB cord-256343-dtfw8o4g 26 36 virus virus NN cord-256343-dtfw8o4g 26 37 - - HYPH cord-256343-dtfw8o4g 26 38 to to IN cord-256343-dtfw8o4g 26 39 - - HYPH cord-256343-dtfw8o4g 26 40 cell cell NN cord-256343-dtfw8o4g 26 41 and and CC cord-256343-dtfw8o4g 26 42 cellto cellto NN cord-256343-dtfw8o4g 26 43 - - HYPH cord-256343-dtfw8o4g 26 44 cell cell NN cord-256343-dtfw8o4g 26 45 membranes membrane NNS cord-256343-dtfw8o4g 26 46 ( ( -LRB- cord-256343-dtfw8o4g 26 47 Masters Masters NNPS cord-256343-dtfw8o4g 26 48 , , , cord-256343-dtfw8o4g 26 49 2006 2006 CD cord-256343-dtfw8o4g 26 50 ) ) -RRB- cord-256343-dtfw8o4g 26 51 . . . cord-256343-dtfw8o4g 27 1 The the DT cord-256343-dtfw8o4g 27 2 nucleocapsid nucleocapsid NN cord-256343-dtfw8o4g 27 3 ( ( -LRB- cord-256343-dtfw8o4g 27 4 N N NNP cord-256343-dtfw8o4g 27 5 ) ) -RRB- cord-256343-dtfw8o4g 27 6 protein protein NN cord-256343-dtfw8o4g 27 7 binds bind VBZ cord-256343-dtfw8o4g 27 8 to to IN cord-256343-dtfw8o4g 27 9 the the DT cord-256343-dtfw8o4g 27 10 genomic genomic JJ cord-256343-dtfw8o4g 27 11 RNA RNA NNP cord-256343-dtfw8o4g 27 12 due due IN cord-256343-dtfw8o4g 27 13 to to IN cord-256343-dtfw8o4g 27 14 its -PRON- PRP$ cord-256343-dtfw8o4g 27 15 positively positively RB cord-256343-dtfw8o4g 27 16 charged charge VBN cord-256343-dtfw8o4g 27 17 amino amino NN cord-256343-dtfw8o4g 27 18 acid acid NN cord-256343-dtfw8o4g 27 19 domains domain NNS cord-256343-dtfw8o4g 27 20 , , , cord-256343-dtfw8o4g 27 21 and and CC cord-256343-dtfw8o4g 27 22 though though IN cord-256343-dtfw8o4g 27 23 under under IN cord-256343-dtfw8o4g 27 24 a a DT cord-256343-dtfw8o4g 27 25 more more RBR cord-256343-dtfw8o4g 27 26 strict strict JJ cord-256343-dtfw8o4g 27 27 mutation mutation NN cord-256343-dtfw8o4g 27 28 constraint constraint NN cord-256343-dtfw8o4g 27 29 than than IN cord-256343-dtfw8o4g 27 30 S S NNP cord-256343-dtfw8o4g 27 31 , , , cord-256343-dtfw8o4g 27 32 positive positive JJ cord-256343-dtfw8o4g 27 33 selection selection NN cord-256343-dtfw8o4g 27 34 plays play VBZ cord-256343-dtfw8o4g 27 35 a a DT cord-256343-dtfw8o4g 27 36 role role NN cord-256343-dtfw8o4g 27 37 in in IN cord-256343-dtfw8o4g 27 38 N n CD cord-256343-dtfw8o4g 27 39 evolution evolution NN cord-256343-dtfw8o4g 27 40 ( ( -LRB- cord-256343-dtfw8o4g 28 1 Kuo Kuo NNP cord-256343-dtfw8o4g 28 2 et et NNP cord-256343-dtfw8o4g 28 3 al al NNP cord-256343-dtfw8o4g 28 4 . . . cord-256343-dtfw8o4g 29 1 , , , cord-256343-dtfw8o4g 29 2 2013 2013 CD cord-256343-dtfw8o4g 29 3 ; ; : cord-256343-dtfw8o4g 29 4 Masters Masters NNPS cord-256343-dtfw8o4g 29 5 , , , cord-256343-dtfw8o4g 29 6 2006 2006 CD cord-256343-dtfw8o4g 29 7 ) ) -RRB- cord-256343-dtfw8o4g 29 8 . . . cord-256343-dtfw8o4g 30 1 The the DT cord-256343-dtfw8o4g 30 2 codon codon NN cord-256343-dtfw8o4g 30 3 usage usage NN cord-256343-dtfw8o4g 30 4 of of IN cord-256343-dtfw8o4g 30 5 A. a. NN cord-256343-dtfw8o4g 30 6 coronavirus coronavirus NN cord-256343-dtfw8o4g 30 7 has have VBZ cord-256343-dtfw8o4g 30 8 been be VBN cord-256343-dtfw8o4g 30 9 reported report VBN cord-256343-dtfw8o4g 30 10 to to TO cord-256343-dtfw8o4g 30 11 be be VB cord-256343-dtfw8o4g 30 12 highly highly RB cord-256343-dtfw8o4g 30 13 to to TO cord-256343-dtfw8o4g 30 14 moderately moderately RB cord-256343-dtfw8o4g 30 15 biased biased JJ cord-256343-dtfw8o4g 30 16 but but CC cord-256343-dtfw8o4g 30 17 closer close JJR cord-256343-dtfw8o4g 30 18 to to IN cord-256343-dtfw8o4g 30 19 that that DT cord-256343-dtfw8o4g 30 20 found find VBN cord-256343-dtfw8o4g 30 21 in in IN cord-256343-dtfw8o4g 30 22 the the DT cord-256343-dtfw8o4g 30 23 respiratory respiratory JJ cord-256343-dtfw8o4g 30 24 tract tract NN cord-256343-dtfw8o4g 30 25 of of IN cord-256343-dtfw8o4g 30 26 Gallus Gallus NNP cord-256343-dtfw8o4g 30 27 gallus gallus NN cord-256343-dtfw8o4g 30 28 when when WRB cord-256343-dtfw8o4g 30 29 compared compare VBN cord-256343-dtfw8o4g 30 30 to to IN cord-256343-dtfw8o4g 30 31 other other JJ cord-256343-dtfw8o4g 30 32 tissues tissue NNS cord-256343-dtfw8o4g 30 33 ( ( -LRB- cord-256343-dtfw8o4g 30 34 Brandão Brandão NNP cord-256343-dtfw8o4g 30 35 , , , cord-256343-dtfw8o4g 30 36 2012 2012 CD cord-256343-dtfw8o4g 30 37 ) ) -RRB- cord-256343-dtfw8o4g 30 38 . . . cord-256343-dtfw8o4g 31 1 However however RB cord-256343-dtfw8o4g 31 2 , , , cord-256343-dtfw8o4g 31 3 that that DT cord-256343-dtfw8o4g 31 4 report report NN cord-256343-dtfw8o4g 31 5 was be VBD cord-256343-dtfw8o4g 31 6 limited limit VBN cord-256343-dtfw8o4g 31 7 because because IN cord-256343-dtfw8o4g 31 8 codon codon NN cord-256343-dtfw8o4g 31 9 usage usage NN cord-256343-dtfw8o4g 31 10 was be VBD cord-256343-dtfw8o4g 31 11 measured measure VBN cord-256343-dtfw8o4g 31 12 based base VBN cord-256343-dtfw8o4g 31 13 on on IN cord-256343-dtfw8o4g 31 14 only only RB cord-256343-dtfw8o4g 31 15 the the DT cord-256343-dtfw8o4g 31 16 spike spike NN cord-256343-dtfw8o4g 31 17 gene gene NN cord-256343-dtfw8o4g 31 18 . . . cord-256343-dtfw8o4g 32 1 The the DT cord-256343-dtfw8o4g 32 2 aim aim NN cord-256343-dtfw8o4g 32 3 of of IN cord-256343-dtfw8o4g 32 4 this this DT cord-256343-dtfw8o4g 32 5 study study NN cord-256343-dtfw8o4g 32 6 was be VBD cord-256343-dtfw8o4g 32 7 to to TO cord-256343-dtfw8o4g 32 8 assess assess VB cord-256343-dtfw8o4g 32 9 the the DT cord-256343-dtfw8o4g 32 10 evolution evolution NN cord-256343-dtfw8o4g 32 11 of of IN cord-256343-dtfw8o4g 32 12 codon codon NN cord-256343-dtfw8o4g 32 13 usage usage NN cord-256343-dtfw8o4g 32 14 in in IN cord-256343-dtfw8o4g 32 15 viral viral JJ cord-256343-dtfw8o4g 32 16 structural structural JJ cord-256343-dtfw8o4g 32 17 and and CC cord-256343-dtfw8o4g 32 18 non non JJ cord-256343-dtfw8o4g 32 19 - - JJ cord-256343-dtfw8o4g 32 20 structural structural JJ cord-256343-dtfw8o4g 32 21 genes gene NNS cord-256343-dtfw8o4g 32 22 and and CC cord-256343-dtfw8o4g 32 23 their -PRON- PRP$ cord-256343-dtfw8o4g 32 24 molecular molecular JJ cord-256343-dtfw8o4g 32 25 relationship relationship NN cord-256343-dtfw8o4g 32 26 with with IN cord-256343-dtfw8o4g 32 27 host host NN cord-256343-dtfw8o4g 32 28 codon codon NN cord-256343-dtfw8o4g 32 29 usage usage NN cord-256343-dtfw8o4g 32 30 using use VBG cord-256343-dtfw8o4g 32 31 A. a. NN cord-256343-dtfw8o4g 32 32 coronavirus coronavirus NN cord-256343-dtfw8o4g 32 33 and and CC cord-256343-dtfw8o4g 32 34 its -PRON- PRP$ cord-256343-dtfw8o4g 32 35 natural natural JJ cord-256343-dtfw8o4g 32 36 host host NN cord-256343-dtfw8o4g 32 37 G. G. NNP cord-256343-dtfw8o4g 32 38 gallus gallus NN cord-256343-dtfw8o4g 32 39 as as IN cord-256343-dtfw8o4g 32 40 a a DT cord-256343-dtfw8o4g 32 41 model model NN cord-256343-dtfw8o4g 32 42 . . . cord-256343-dtfw8o4g 33 1 For for IN cord-256343-dtfw8o4g 33 2 A. a. NN cord-256343-dtfw8o4g 33 3 coronavirus coronavirus NN cord-256343-dtfw8o4g 33 4 , , , cord-256343-dtfw8o4g 33 5 sequences sequence NNS cord-256343-dtfw8o4g 33 6 were be VBD cord-256343-dtfw8o4g 33 7 chosen choose VBN cord-256343-dtfw8o4g 33 8 to to TO cord-256343-dtfw8o4g 33 9 promote promote VB cord-256343-dtfw8o4g 33 10 diversity diversity NN cord-256343-dtfw8o4g 33 11 of of IN cord-256343-dtfw8o4g 33 12 geographic geographic JJ cord-256343-dtfw8o4g 33 13 origin origin NN cord-256343-dtfw8o4g 33 14 and and CC cord-256343-dtfw8o4g 33 15 serotype serotype NN cord-256343-dtfw8o4g 33 16 / / SYM cord-256343-dtfw8o4g 33 17 genotypes genotype NNS cord-256343-dtfw8o4g 33 18 , , , cord-256343-dtfw8o4g 33 19 including include VBG cord-256343-dtfw8o4g 33 20 the the DT cord-256343-dtfw8o4g 33 21 archetypical archetypical JJ cord-256343-dtfw8o4g 33 22 strains strain NNS cord-256343-dtfw8o4g 33 23 , , , cord-256343-dtfw8o4g 33 24 with with IN cord-256343-dtfw8o4g 33 25 an an DT cord-256343-dtfw8o4g 33 26 effort effort NN cord-256343-dtfw8o4g 33 27 to to TO cord-256343-dtfw8o4g 33 28 keep keep VB cord-256343-dtfw8o4g 33 29 the the DT cord-256343-dtfw8o4g 33 30 same same JJ cord-256343-dtfw8o4g 33 31 datasets dataset NNS cord-256343-dtfw8o4g 33 32 if if IN cord-256343-dtfw8o4g 33 33 possible possible JJ cord-256343-dtfw8o4g 33 34 . . . cord-256343-dtfw8o4g 34 1 Because because IN cord-256343-dtfw8o4g 34 2 the the DT cord-256343-dtfw8o4g 34 3 number number NN cord-256343-dtfw8o4g 34 4 of of IN cord-256343-dtfw8o4g 34 5 complete complete JJ cord-256343-dtfw8o4g 34 6 genomes genome NNS cord-256343-dtfw8o4g 34 7 and and CC cord-256343-dtfw8o4g 34 8 genes gene NNS cord-256343-dtfw8o4g 34 9 for for IN cord-256343-dtfw8o4g 34 10 A. a. NN cord-256343-dtfw8o4g 34 11 coronavirus coronavirus NN cord-256343-dtfw8o4g 34 12 available available JJ cord-256343-dtfw8o4g 34 13 in in IN cord-256343-dtfw8o4g 34 14 GenBank GenBank NNP cord-256343-dtfw8o4g 34 15 did do VBD cord-256343-dtfw8o4g 34 16 not not RB cord-256343-dtfw8o4g 34 17 allow allow VB cord-256343-dtfw8o4g 34 18 for for IN cord-256343-dtfw8o4g 34 19 the the DT cord-256343-dtfw8o4g 34 20 representation representation NN cord-256343-dtfw8o4g 34 21 of of IN cord-256343-dtfw8o4g 34 22 such such JJ cord-256343-dtfw8o4g 34 23 diversity diversity NN cord-256343-dtfw8o4g 34 24 , , , cord-256343-dtfw8o4g 34 25 only only RB cord-256343-dtfw8o4g 34 26 partial partial JJ cord-256343-dtfw8o4g 34 27 genes gene NNS cord-256343-dtfw8o4g 34 28 were be VBD cord-256343-dtfw8o4g 34 29 used use VBN cord-256343-dtfw8o4g 34 30 in in IN cord-256343-dtfw8o4g 34 31 this this DT cord-256343-dtfw8o4g 34 32 study study NN cord-256343-dtfw8o4g 34 33 instead instead RB cord-256343-dtfw8o4g 34 34 of of IN cord-256343-dtfw8o4g 34 35 complete complete JJ cord-256343-dtfw8o4g 34 36 ones one NNS cord-256343-dtfw8o4g 34 37 to to TO cord-256343-dtfw8o4g 34 38 have have VB cord-256343-dtfw8o4g 34 39 the the DT cord-256343-dtfw8o4g 34 40 most most RBS cord-256343-dtfw8o4g 34 41 diverse diverse JJ cord-256343-dtfw8o4g 34 42 dataset dataset NN cord-256343-dtfw8o4g 34 43 possible possible JJ cord-256343-dtfw8o4g 34 44 . . . cord-256343-dtfw8o4g 35 1 As as IN cord-256343-dtfw8o4g 35 2 the the DT cord-256343-dtfw8o4g 35 3 accuracy accuracy NN cord-256343-dtfw8o4g 35 4 of of IN cord-256343-dtfw8o4g 35 5 codon codon NN cord-256343-dtfw8o4g 35 6 usage usage NN cord-256343-dtfw8o4g 35 7 measurements measurement NNS cord-256343-dtfw8o4g 35 8 is be VBZ cord-256343-dtfw8o4g 35 9 lower low JJR cord-256343-dtfw8o4g 35 10 for for IN cord-256343-dtfw8o4g 35 11 short short JJ cord-256343-dtfw8o4g 35 12 sequences sequence NNS cord-256343-dtfw8o4g 35 13 , , , cord-256343-dtfw8o4g 35 14 sequences sequence VBZ cord-256343-dtfw8o4g 35 15 < < XX cord-256343-dtfw8o4g 35 16 100 100 CD cord-256343-dtfw8o4g 35 17 codons codon NNS cord-256343-dtfw8o4g 35 18 in in IN cord-256343-dtfw8o4g 35 19 length length NN cord-256343-dtfw8o4g 36 1 ( ( -LRB- cord-256343-dtfw8o4g 36 2 Roth Roth NNP cord-256343-dtfw8o4g 36 3 et et FW cord-256343-dtfw8o4g 36 4 al al NNP cord-256343-dtfw8o4g 36 5 . . NNP cord-256343-dtfw8o4g 36 6 , , , cord-256343-dtfw8o4g 36 7 2012 2012 CD cord-256343-dtfw8o4g 36 8 ) ) -RRB- cord-256343-dtfw8o4g 36 9 were be VBD cord-256343-dtfw8o4g 36 10 not not RB cord-256343-dtfw8o4g 36 11 included include VBN cord-256343-dtfw8o4g 36 12 . . . cord-256343-dtfw8o4g 37 1 Sequence sequence NN cord-256343-dtfw8o4g 37 2 redundancy redundancy NN cord-256343-dtfw8o4g 37 3 was be VBD cord-256343-dtfw8o4g 37 4 avoided avoid VBN cord-256343-dtfw8o4g 37 5 by by IN cord-256343-dtfw8o4g 37 6 keeping keep VBG cord-256343-dtfw8o4g 37 7 only only RB cord-256343-dtfw8o4g 37 8 one one CD cord-256343-dtfw8o4g 37 9 sequence sequence NN cord-256343-dtfw8o4g 37 10 if if IN cord-256343-dtfw8o4g 37 11 any any DT cord-256343-dtfw8o4g 37 12 100 100 CD cord-256343-dtfw8o4g 37 13 % % NN cord-256343-dtfw8o4g 37 14 nucleotide nucleotide JJ cord-256343-dtfw8o4g 37 15 identity identity NN cord-256343-dtfw8o4g 37 16 was be VBD cord-256343-dtfw8o4g 37 17 found find VBN cord-256343-dtfw8o4g 37 18 . . . cord-256343-dtfw8o4g 38 1 Following follow VBG cord-256343-dtfw8o4g 38 2 these these DT cord-256343-dtfw8o4g 38 3 criteria criterion NNS cord-256343-dtfw8o4g 38 4 , , , cord-256343-dtfw8o4g 38 5 this this DT cord-256343-dtfw8o4g 38 6 study study NN cord-256343-dtfw8o4g 38 7 included include VBD cord-256343-dtfw8o4g 38 8 64 64 CD cord-256343-dtfw8o4g 38 9 S s NN cord-256343-dtfw8o4g 38 10 protein protein NN cord-256343-dtfw8o4g 38 11 sequences sequence NNS cord-256343-dtfw8o4g 38 12 , , , cord-256343-dtfw8o4g 38 13 codons codon NNS cord-256343-dtfw8o4g 38 14 1 1 CD cord-256343-dtfw8o4g 38 15 - - SYM cord-256343-dtfw8o4g 38 16 169 169 CD cord-256343-dtfw8o4g 38 17 ( ( -LRB- cord-256343-dtfw8o4g 38 18 14.6 14.6 CD cord-256343-dtfw8o4g 38 19 % % NN cord-256343-dtfw8o4g 38 20 of of IN cord-256343-dtfw8o4g 38 21 the the DT cord-256343-dtfw8o4g 38 22 1162 1162 CD cord-256343-dtfw8o4g 38 23 S S NNP cord-256343-dtfw8o4g 38 24 codons codon NNS cord-256343-dtfw8o4g 38 25 ) ) -RRB- cord-256343-dtfw8o4g 38 26 ; ; : cord-256343-dtfw8o4g 38 27 25 25 CD cord-256343-dtfw8o4g 38 28 N n CD cord-256343-dtfw8o4g 38 29 protein protein NN cord-256343-dtfw8o4g 38 30 sequences sequence NNS cord-256343-dtfw8o4g 38 31 , , , cord-256343-dtfw8o4g 38 32 codons codon NNS cord-256343-dtfw8o4g 38 33 301 301 CD cord-256343-dtfw8o4g 38 34 - - SYM cord-256343-dtfw8o4g 38 35 409 409 CD cord-256343-dtfw8o4g 38 36 ( ( -LRB- cord-256343-dtfw8o4g 38 37 26.7 26.7 CD cord-256343-dtfw8o4g 38 38 % % NN cord-256343-dtfw8o4g 38 39 of of IN cord-256343-dtfw8o4g 38 40 the the DT cord-256343-dtfw8o4g 38 41 409 409 CD cord-256343-dtfw8o4g 38 42 N n CD cord-256343-dtfw8o4g 38 43 codons codon NNS cord-256343-dtfw8o4g 38 44 ) ) -RRB- cord-256343-dtfw8o4g 38 45 ; ; : cord-256343-dtfw8o4g 38 46 18 18 CD cord-256343-dtfw8o4g 38 47 NSP2 NSP2 NNP cord-256343-dtfw8o4g 38 48 sequences sequence NNS cord-256343-dtfw8o4g 38 49 , , , cord-256343-dtfw8o4g 38 50 codons codon NNS cord-256343-dtfw8o4g 38 51 1 1 CD cord-256343-dtfw8o4g 38 52 - - SYM cord-256343-dtfw8o4g 38 53 245 245 CD cord-256343-dtfw8o4g 38 54 ( ( -LRB- cord-256343-dtfw8o4g 38 55 36.4 36.4 CD cord-256343-dtfw8o4g 38 56 % % NN cord-256343-dtfw8o4g 38 57 of of IN cord-256343-dtfw8o4g 38 58 the the DT cord-256343-dtfw8o4g 38 59 673 673 CD cord-256343-dtfw8o4g 38 60 NSP2 NSP2 NNP cord-256343-dtfw8o4g 38 61 codons codon NNS cord-256343-dtfw8o4g 38 62 ) ) -RRB- cord-256343-dtfw8o4g 38 63 ; ; : cord-256343-dtfw8o4g 38 64 and and CC cord-256343-dtfw8o4g 38 65 15 15 CD cord-256343-dtfw8o4g 38 66 papain papain NN cord-256343-dtfw8o4g 38 67 - - HYPH cord-256343-dtfw8o4g 38 68 like like JJ cord-256343-dtfw8o4g 38 69 protease protease NN cord-256343-dtfw8o4g 38 70 sequences sequence NNS cord-256343-dtfw8o4g 38 71 , , , cord-256343-dtfw8o4g 38 72 codons codon NNS cord-256343-dtfw8o4g 38 73 3 3 CD cord-256343-dtfw8o4g 38 74 - - SYM cord-256343-dtfw8o4g 38 75 437 437 CD cord-256343-dtfw8o4g 38 76 ( ( -LRB- cord-256343-dtfw8o4g 38 77 99.5 99.5 CD cord-256343-dtfw8o4g 38 78 % % NN cord-256343-dtfw8o4g 38 79 of of IN cord-256343-dtfw8o4g 38 80 the the DT cord-256343-dtfw8o4g 38 81 437 437 CD cord-256343-dtfw8o4g 38 82 PL pl NN cord-256343-dtfw8o4g 38 83 pro pro JJ cord-256343-dtfw8o4g 38 84 codons codon NNS cord-256343-dtfw8o4g 38 85 ) ) -RRB- cord-256343-dtfw8o4g 38 86 . . . cord-256343-dtfw8o4g 39 1 The the DT cord-256343-dtfw8o4g 39 2 accession accession NN cord-256343-dtfw8o4g 39 3 numbers number NNS cord-256343-dtfw8o4g 39 4 are be VBP cord-256343-dtfw8o4g 39 5 shown show VBN cord-256343-dtfw8o4g 39 6 in in IN cord-256343-dtfw8o4g 39 7 Fig Fig NNP cord-256343-dtfw8o4g 39 8 . . . cord-256343-dtfw8o4g 40 1 1 1 LS cord-256343-dtfw8o4g 40 2 . . . cord-256343-dtfw8o4g 41 1 All all DT cord-256343-dtfw8o4g 41 2 indicated indicate VBN cord-256343-dtfw8o4g 41 3 positions position NNS cord-256343-dtfw8o4g 41 4 are be VBP cord-256343-dtfw8o4g 41 5 relative relative JJ cord-256343-dtfw8o4g 41 6 to to IN cord-256343-dtfw8o4g 41 7 the the DT cord-256343-dtfw8o4g 41 8 complete complete JJ cord-256343-dtfw8o4g 41 9 genome genome NN cord-256343-dtfw8o4g 41 10 of of IN cord-256343-dtfw8o4g 41 11 the the DT cord-256343-dtfw8o4g 41 12 Avian avian JJ cord-256343-dtfw8o4g 41 13 infectious infectious JJ cord-256343-dtfw8o4g 41 14 bronchitis bronchitis NN cord-256343-dtfw8o4g 41 15 virus virus NN cord-256343-dtfw8o4g 41 16 strain strain VBP cord-256343-dtfw8o4g 41 17 M41 M41 NNP cord-256343-dtfw8o4g 41 18 ( ( -LRB- cord-256343-dtfw8o4g 41 19 DQ834384.1 DQ834384.1 NNP cord-256343-dtfw8o4g 41 20 ) ) -RRB- cord-256343-dtfw8o4g 41 21 . . . cord-256343-dtfw8o4g 42 1 Aiming aim VBG cord-256343-dtfw8o4g 42 2 to to TO cord-256343-dtfw8o4g 42 3 assess assess VB cord-256343-dtfw8o4g 42 4 the the DT cord-256343-dtfw8o4g 42 5 codon codon NN cord-256343-dtfw8o4g 42 6 usage usage NN cord-256343-dtfw8o4g 42 7 of of IN cord-256343-dtfw8o4g 42 8 the the DT cord-256343-dtfw8o4g 42 9 different different JJ cord-256343-dtfw8o4g 42 10 tissues tissue NNS cord-256343-dtfw8o4g 42 11 in in IN cord-256343-dtfw8o4g 42 12 which which WDT cord-256343-dtfw8o4g 42 13 A. a. NN cord-256343-dtfw8o4g 42 14 coronavirus coronavirus NN cord-256343-dtfw8o4g 42 15 replicates replicate VBZ cord-256343-dtfw8o4g 42 16 in in IN cord-256343-dtfw8o4g 42 17 chicken chicken NN cord-256343-dtfw8o4g 42 18 , , , cord-256343-dtfw8o4g 42 19 non non JJ cord-256343-dtfw8o4g 42 20 - - JJ cord-256343-dtfw8o4g 42 21 redundant redundant JJ cord-256343-dtfw8o4g 42 22 complete complete JJ cord-256343-dtfw8o4g 42 23 codon codon NN cord-256343-dtfw8o4g 42 24 sequences sequence NNS cord-256343-dtfw8o4g 42 25 were be VBD cord-256343-dtfw8o4g 42 26 retrieved retrieve VBN cord-256343-dtfw8o4g 42 27 from from IN cord-256343-dtfw8o4g 42 28 the the DT cord-256343-dtfw8o4g 42 29 GenBank GenBank NNP cord-256343-dtfw8o4g 42 30 database database NN cord-256343-dtfw8o4g 42 31 and and CC cord-256343-dtfw8o4g 42 32 from from IN cord-256343-dtfw8o4g 42 33 the the DT cord-256343-dtfw8o4g 42 34 G. G. NNP cord-256343-dtfw8o4g 42 35 gallus gallus NN cord-256343-dtfw8o4g 42 36 genome genome NN cord-256343-dtfw8o4g 42 37 project project NN cord-256343-dtfw8o4g 42 38 for for IN cord-256343-dtfw8o4g 42 39 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 42 40 , , , cord-256343-dtfw8o4g 42 41 expressed express VBN cord-256343-dtfw8o4g 42 42 in in IN cord-256343-dtfw8o4g 42 43 the the DT cord-256343-dtfw8o4g 42 44 duodenum duodenum NN cord-256343-dtfw8o4g 42 45 ( ( -LRB- cord-256343-dtfw8o4g 42 46 NM NM NNP cord-256343-dtfw8o4g 42 47 001001741.1 001001741.1 CD cord-256343-dtfw8o4g 42 48 and and CC cord-256343-dtfw8o4g 42 49 GFC GFC NNP cord-256343-dtfw8o4g 42 50 000002315.3 000002315.3 CD cord-256343-dtfw8o4g 42 51 ) ) -RRB- cord-256343-dtfw8o4g 42 52 ; ; : cord-256343-dtfw8o4g 42 53 lung lung NN cord-256343-dtfw8o4g 42 54 surfactant surfactant NN cord-256343-dtfw8o4g 42 55 pulmonary pulmonary JJ cord-256343-dtfw8o4g 42 56 - - HYPH cord-256343-dtfw8o4g 42 57 associated associated JJ cord-256343-dtfw8o4g 42 58 protein protein NN cord-256343-dtfw8o4g 42 59 A1 a1 NN cord-256343-dtfw8o4g 42 60 ( ( -LRB- cord-256343-dtfw8o4g 42 61 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 42 62 ) ) -RRB- cord-256343-dtfw8o4g 42 63 , , , cord-256343-dtfw8o4g 42 64 expressed express VBN cord-256343-dtfw8o4g 42 65 in in IN cord-256343-dtfw8o4g 42 66 the the DT cord-256343-dtfw8o4g 42 67 lungs lung NNS cord-256343-dtfw8o4g 42 68 ( ( -LRB- cord-256343-dtfw8o4g 42 69 NM NM NNP cord-256343-dtfw8o4g 42 70 204606.1 204606.1 CD cord-256343-dtfw8o4g 42 71 and and CC cord-256343-dtfw8o4g 42 72 GFC GFC NNP cord-256343-dtfw8o4g 42 73 000002315.3 000002315.3 CD cord-256343-dtfw8o4g 42 74 ) ) -RRB- cord-256343-dtfw8o4g 42 75 ; ; : cord-256343-dtfw8o4g 42 76 vitamin vitamin NN cord-256343-dtfw8o4g 42 77 D D NNP cord-256343-dtfw8o4g 42 78 receptor receptor NN cord-256343-dtfw8o4g 42 79 , , , cord-256343-dtfw8o4g 42 80 expressed express VBN cord-256343-dtfw8o4g 42 81 in in IN cord-256343-dtfw8o4g 42 82 the the DT cord-256343-dtfw8o4g 42 83 kidneys kidney NNS cord-256343-dtfw8o4g 42 84 ( ( -LRB- cord-256343-dtfw8o4g 42 85 NM NM NNP cord-256343-dtfw8o4g 42 86 205098.1 205098.1 CD cord-256343-dtfw8o4g 42 87 and and CC cord-256343-dtfw8o4g 42 88 GFC GFC NNP cord-256343-dtfw8o4g 42 89 000002315.3 000002315.3 CD cord-256343-dtfw8o4g 42 90 ) ) -RRB- cord-256343-dtfw8o4g 42 91 ; ; : cord-256343-dtfw8o4g 42 92 and and CC cord-256343-dtfw8o4g 42 93 ovomucin ovomucin NNS cord-256343-dtfw8o4g 42 94 alpha alpha NNP cord-256343-dtfw8o4g 42 95 subunit subunit NNP cord-256343-dtfw8o4g 42 96 , , , cord-256343-dtfw8o4g 42 97 expressed express VBN cord-256343-dtfw8o4g 42 98 in in IN cord-256343-dtfw8o4g 42 99 the the DT cord-256343-dtfw8o4g 42 100 oviduct oviduct NN cord-256343-dtfw8o4g 42 101 ( ( -LRB- cord-256343-dtfw8o4g 42 102 AB046524.1 AB046524.1 NNP cord-256343-dtfw8o4g 42 103 and and CC cord-256343-dtfw8o4g 42 104 GFC GFC NNP cord-256343-dtfw8o4g 42 105 000002315.3 000002315.3 CD cord-256343-dtfw8o4g 42 106 ) ) -RRB- cord-256343-dtfw8o4g 42 107 . . . cord-256343-dtfw8o4g 43 1 As as IN cord-256343-dtfw8o4g 43 2 a a DT cord-256343-dtfw8o4g 43 3 reference reference NN cord-256343-dtfw8o4g 43 4 , , , cord-256343-dtfw8o4g 43 5 the the DT cord-256343-dtfw8o4g 43 6 complete complete JJ cord-256343-dtfw8o4g 43 7 G. G. NNP cord-256343-dtfw8o4g 43 8 gallus gallus NN cord-256343-dtfw8o4g 43 9 beta beta NN cord-256343-dtfw8o4g 43 10 - - HYPH cord-256343-dtfw8o4g 43 11 actin actin NN cord-256343-dtfw8o4g 43 12 gene gene NN cord-256343-dtfw8o4g 43 13 ( ( -LRB- cord-256343-dtfw8o4g 43 14 L08165 L08165 NNP cord-256343-dtfw8o4g 43 15 and and CC cord-256343-dtfw8o4g 43 16 GFC GFC NNP cord-256343-dtfw8o4g 43 17 000002315.3 000002315.3 CD cord-256343-dtfw8o4g 43 18 ) ) -RRB- cord-256343-dtfw8o4g 43 19 was be VBD cord-256343-dtfw8o4g 43 20 included include VBN cord-256343-dtfw8o4g 43 21 in in IN cord-256343-dtfw8o4g 43 22 the the DT cord-256343-dtfw8o4g 43 23 analyses analysis NNS cord-256343-dtfw8o4g 43 24 as as IN cord-256343-dtfw8o4g 43 25 a a DT cord-256343-dtfw8o4g 43 26 ubiquitously ubiquitously RB cord-256343-dtfw8o4g 43 27 expressed express VBN cord-256343-dtfw8o4g 43 28 gene gene NN cord-256343-dtfw8o4g 43 29 . . . cord-256343-dtfw8o4g 44 1 All all DT cord-256343-dtfw8o4g 44 2 sequences sequence NNS cord-256343-dtfw8o4g 44 3 used use VBN cord-256343-dtfw8o4g 44 4 in in IN cord-256343-dtfw8o4g 44 5 this this DT cord-256343-dtfw8o4g 44 6 study study NN cord-256343-dtfw8o4g 44 7 can can MD cord-256343-dtfw8o4g 44 8 be be VB cord-256343-dtfw8o4g 44 9 found find VBN cord-256343-dtfw8o4g 44 10 in in IN cord-256343-dtfw8o4g 44 11 Supplementary supplementary JJ cord-256343-dtfw8o4g 44 12 material material NN cord-256343-dtfw8o4g 44 13 1 1 CD cord-256343-dtfw8o4g 44 14 . . . cord-256343-dtfw8o4g 45 1 RSCU RSCU NNP cord-256343-dtfw8o4g 45 2 , , , cord-256343-dtfw8o4g 45 3 the the DT cord-256343-dtfw8o4g 45 4 relationship relationship NN cord-256343-dtfw8o4g 45 5 between between IN cord-256343-dtfw8o4g 45 6 the the DT cord-256343-dtfw8o4g 45 7 observed observed JJ cord-256343-dtfw8o4g 45 8 and and CC cord-256343-dtfw8o4g 45 9 the the DT cord-256343-dtfw8o4g 45 10 expected expect VBN cord-256343-dtfw8o4g 45 11 frequency frequency NN cord-256343-dtfw8o4g 45 12 of of IN cord-256343-dtfw8o4g 45 13 a a DT cord-256343-dtfw8o4g 45 14 codon codon NN cord-256343-dtfw8o4g 45 15 if if IN cord-256343-dtfw8o4g 45 16 the the DT cord-256343-dtfw8o4g 45 17 synonymous synonymous JJ cord-256343-dtfw8o4g 45 18 codon codon NN cord-256343-dtfw8o4g 45 19 usage usage NN cord-256343-dtfw8o4g 45 20 is be VBZ cord-256343-dtfw8o4g 45 21 random random JJ cord-256343-dtfw8o4g 46 1 ( ( -LRB- cord-256343-dtfw8o4g 46 2 Roth Roth NNP cord-256343-dtfw8o4g 46 3 et et FW cord-256343-dtfw8o4g 46 4 al al NNP cord-256343-dtfw8o4g 46 5 . . NNP cord-256343-dtfw8o4g 46 6 , , , cord-256343-dtfw8o4g 46 7 2012 2012 CD cord-256343-dtfw8o4g 46 8 ) ) -RRB- cord-256343-dtfw8o4g 46 9 , , , cord-256343-dtfw8o4g 46 10 was be VBD cord-256343-dtfw8o4g 46 11 calculated calculate VBN cord-256343-dtfw8o4g 46 12 for for IN cord-256343-dtfw8o4g 46 13 59 59 CD cord-256343-dtfw8o4g 46 14 codons codon NNS cord-256343-dtfw8o4g 46 15 , , , cord-256343-dtfw8o4g 46 16 excluding exclude VBG cord-256343-dtfw8o4g 46 17 the the DT cord-256343-dtfw8o4g 46 18 single single JJ cord-256343-dtfw8o4g 46 19 codons codon NNS cord-256343-dtfw8o4g 46 20 of of IN cord-256343-dtfw8o4g 46 21 methionine methionine NN cord-256343-dtfw8o4g 46 22 and and CC cord-256343-dtfw8o4g 46 23 tryptophan tryptophan NN cord-256343-dtfw8o4g 46 24 and and CC cord-256343-dtfw8o4g 46 25 the the DT cord-256343-dtfw8o4g 46 26 three three CD cord-256343-dtfw8o4g 46 27 stop stop NN cord-256343-dtfw8o4g 46 28 codons codon NNS cord-256343-dtfw8o4g 46 29 , , , cord-256343-dtfw8o4g 46 30 using use VBG cord-256343-dtfw8o4g 46 31 the the DT cord-256343-dtfw8o4g 46 32 equation equation NN cord-256343-dtfw8o4g 46 33 RSCU RSCU NNP cord-256343-dtfw8o4g 46 34 i i NN cord-256343-dtfw8o4g 46 35 = = NFP cord-256343-dtfw8o4g 47 1 X X NNP cord-256343-dtfw8o4g 47 2 i i PRP cord-256343-dtfw8o4g 48 1 / / NFP cord-256343-dtfw8o4g 49 1 ( ( -LRB- cord-256343-dtfw8o4g 49 2 i i PRP cord-256343-dtfw8o4g 50 1 X X NNP cord-256343-dtfw8o4g 50 2 i i PRP cord-256343-dtfw8o4g 50 3 /m /m NNP cord-256343-dtfw8o4g 50 4 ) ) -RRB- cord-256343-dtfw8o4g 51 1 ( ( -LRB- cord-256343-dtfw8o4g 51 2 Nei Nei NNP cord-256343-dtfw8o4g 51 3 and and CC cord-256343-dtfw8o4g 51 4 Kumar Kumar NNP cord-256343-dtfw8o4g 51 5 , , , cord-256343-dtfw8o4g 51 6 2000 2000 CD cord-256343-dtfw8o4g 51 7 ) ) -RRB- cord-256343-dtfw8o4g 51 8 , , , cord-256343-dtfw8o4g 51 9 where where WRB cord-256343-dtfw8o4g 51 10 X x NN cord-256343-dtfw8o4g 51 11 i i PRP cord-256343-dtfw8o4g 51 12 is be VBZ cord-256343-dtfw8o4g 51 13 the the DT cord-256343-dtfw8o4g 51 14 total total JJ cord-256343-dtfw8o4g 51 15 count count NN cord-256343-dtfw8o4g 51 16 for for IN cord-256343-dtfw8o4g 51 17 a a DT cord-256343-dtfw8o4g 51 18 given give VBN cord-256343-dtfw8o4g 51 19 codon codon NN cord-256343-dtfw8o4g 51 20 , , , cord-256343-dtfw8o4g 52 1 i i PRP cord-256343-dtfw8o4g 53 1 X X NNS cord-256343-dtfw8o4g 54 1 i i PRP cord-256343-dtfw8o4g 54 2 is be VBZ cord-256343-dtfw8o4g 54 3 the the DT cord-256343-dtfw8o4g 54 4 sum sum NN cord-256343-dtfw8o4g 54 5 of of IN cord-256343-dtfw8o4g 54 6 the the DT cord-256343-dtfw8o4g 54 7 count count NN cord-256343-dtfw8o4g 54 8 for for IN cord-256343-dtfw8o4g 54 9 all all DT cord-256343-dtfw8o4g 54 10 synonymous synonymous JJ cord-256343-dtfw8o4g 54 11 codons codon NNS cord-256343-dtfw8o4g 54 12 regarding regard VBG cord-256343-dtfw8o4g 54 13 the the DT cord-256343-dtfw8o4g 54 14 amino amino NN cord-256343-dtfw8o4g 54 15 acid acid NN cord-256343-dtfw8o4g 54 16 under under IN cord-256343-dtfw8o4g 54 17 consideration consideration NN cord-256343-dtfw8o4g 54 18 and and CC cord-256343-dtfw8o4g 54 19 m m NN cord-256343-dtfw8o4g 54 20 is be VBZ cord-256343-dtfw8o4g 54 21 the the DT cord-256343-dtfw8o4g 54 22 number number NN cord-256343-dtfw8o4g 54 23 of of IN cord-256343-dtfw8o4g 54 24 possible possible JJ cord-256343-dtfw8o4g 54 25 isoacceptors isoacceptor NNS cord-256343-dtfw8o4g 54 26 for for IN cord-256343-dtfw8o4g 54 27 that that DT cord-256343-dtfw8o4g 54 28 amino amino NN cord-256343-dtfw8o4g 54 29 acid acid NN cord-256343-dtfw8o4g 54 30 , , , cord-256343-dtfw8o4g 54 31 implemented implement VBN cord-256343-dtfw8o4g 54 32 in in IN cord-256343-dtfw8o4g 54 33 MEGA MEGA NNP cord-256343-dtfw8o4g 54 34 5.0 5.0 CD cord-256343-dtfw8o4g 54 35 ( ( -LRB- cord-256343-dtfw8o4g 54 36 Tamura Tamura NNP cord-256343-dtfw8o4g 54 37 et et NNP cord-256343-dtfw8o4g 54 38 al al NNP cord-256343-dtfw8o4g 54 39 . . NNP cord-256343-dtfw8o4g 54 40 , , , cord-256343-dtfw8o4g 54 41 2011 2011 CD cord-256343-dtfw8o4g 54 42 ) ) -RRB- cord-256343-dtfw8o4g 54 43 . . . cord-256343-dtfw8o4g 55 1 The the DT cord-256343-dtfw8o4g 55 2 continuous continuous JJ cord-256343-dtfw8o4g 55 3 RSCU RSCU NNP cord-256343-dtfw8o4g 55 4 values value NNS cord-256343-dtfw8o4g 55 5 from from IN cord-256343-dtfw8o4g 55 6 A. a. NN cord-256343-dtfw8o4g 55 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 55 8 and and CC cord-256343-dtfw8o4g 55 9 G. G. NNP cord-256343-dtfw8o4g 55 10 gallus gallus NN cord-256343-dtfw8o4g 55 11 genes gene NNS cord-256343-dtfw8o4g 55 12 were be VBD cord-256343-dtfw8o4g 55 13 converted convert VBN cord-256343-dtfw8o4g 55 14 to to IN cord-256343-dtfw8o4g 55 15 binary binary JJ cord-256343-dtfw8o4g 55 16 data datum NNS cord-256343-dtfw8o4g 55 17 using use VBG cord-256343-dtfw8o4g 55 18 the the DT cord-256343-dtfw8o4g 55 19 value value NN cord-256343-dtfw8o4g 55 20 1 1 CD cord-256343-dtfw8o4g 55 21 for for IN cord-256343-dtfw8o4g 55 22 RSCUs rscu NNS cord-256343-dtfw8o4g 55 23 > > XX cord-256343-dtfw8o4g 56 1 1 1 LS cord-256343-dtfw8o4g 56 2 , , , cord-256343-dtfw8o4g 56 3 when when WRB cord-256343-dtfw8o4g 56 4 a a DT cord-256343-dtfw8o4g 56 5 given give VBN cord-256343-dtfw8o4g 56 6 codon codon NN cord-256343-dtfw8o4g 56 7 was be VBD cord-256343-dtfw8o4g 56 8 preferred prefer VBN cord-256343-dtfw8o4g 56 9 for for IN cord-256343-dtfw8o4g 56 10 a a DT cord-256343-dtfw8o4g 56 11 specific specific JJ cord-256343-dtfw8o4g 56 12 amino amino NN cord-256343-dtfw8o4g 56 13 acid acid NN cord-256343-dtfw8o4g 56 14 , , , cord-256343-dtfw8o4g 56 15 or or CC cord-256343-dtfw8o4g 56 16 0 0 CD cord-256343-dtfw8o4g 56 17 for for IN cord-256343-dtfw8o4g 56 18 RSCUs RSCUs NNP cord-256343-dtfw8o4g 56 19 ≤ ≤ NNP cord-256343-dtfw8o4g 56 20 1 1 CD cord-256343-dtfw8o4g 56 21 , , , cord-256343-dtfw8o4g 56 22 when when WRB cord-256343-dtfw8o4g 56 23 the the DT cord-256343-dtfw8o4g 56 24 codon codon NN cord-256343-dtfw8o4g 56 25 was be VBD cord-256343-dtfw8o4g 56 26 not not RB cord-256343-dtfw8o4g 56 27 preferred prefer VBN cord-256343-dtfw8o4g 57 1 ( ( -LRB- cord-256343-dtfw8o4g 57 2 RSCU RSCU NNP cord-256343-dtfw8o4g 57 3 < < XX cord-256343-dtfw8o4g 57 4 1 1 CD cord-256343-dtfw8o4g 57 5 ) ) -RRB- cord-256343-dtfw8o4g 57 6 or or CC cord-256343-dtfw8o4g 57 7 was be VBD cord-256343-dtfw8o4g 57 8 neutral neutral JJ cord-256343-dtfw8o4g 58 1 ( ( -LRB- cord-256343-dtfw8o4g 58 2 RSCU RSCU NNP cord-256343-dtfw8o4g 58 3 = = SYM cord-256343-dtfw8o4g 58 4 1 1 CD cord-256343-dtfw8o4g 58 5 ) ) -RRB- cord-256343-dtfw8o4g 58 6 . . . cord-256343-dtfw8o4g 59 1 Finally finally RB cord-256343-dtfw8o4g 59 2 , , , cord-256343-dtfw8o4g 59 3 the the DT cord-256343-dtfw8o4g 59 4 combined combine VBN cord-256343-dtfw8o4g 59 5 dataset dataset NN cord-256343-dtfw8o4g 59 6 of of IN cord-256343-dtfw8o4g 59 7 the the DT cord-256343-dtfw8o4g 59 8 four four CD cord-256343-dtfw8o4g 59 9 viral viral JJ cord-256343-dtfw8o4g 59 10 and and CC cord-256343-dtfw8o4g 59 11 five five CD cord-256343-dtfw8o4g 59 12 host host NN cord-256343-dtfw8o4g 59 13 genes gene NNS cord-256343-dtfw8o4g 59 14 was be VBD cord-256343-dtfw8o4g 59 15 used use VBN cord-256343-dtfw8o4g 59 16 to to TO cord-256343-dtfw8o4g 59 17 build build VB cord-256343-dtfw8o4g 59 18 a a DT cord-256343-dtfw8o4g 59 19 binary binary JJ cord-256343-dtfw8o4g 59 20 59 59 CD cord-256343-dtfw8o4g 59 21 characters character NNS cord-256343-dtfw8o4g 59 22 × × NNP cord-256343-dtfw8o4g 59 23 132 132 CD cord-256343-dtfw8o4g 59 24 sequences sequence NNS cord-256343-dtfw8o4g 59 25 matrix matrix NN cord-256343-dtfw8o4g 59 26 ( ( -LRB- cord-256343-dtfw8o4g 59 27 Supplementary supplementary JJ cord-256343-dtfw8o4g 59 28 material material NN cord-256343-dtfw8o4g 59 29 2 2 CD cord-256343-dtfw8o4g 59 30 ) ) -RRB- cord-256343-dtfw8o4g 59 31 for for IN cord-256343-dtfw8o4g 59 32 the the DT cord-256343-dtfw8o4g 59 33 presence presence NN cord-256343-dtfw8o4g 59 34 or or CC cord-256343-dtfw8o4g 59 35 absence absence NN cord-256343-dtfw8o4g 59 36 of of IN cord-256343-dtfw8o4g 59 37 a a DT cord-256343-dtfw8o4g 59 38 preferred preferred JJ cord-256343-dtfw8o4g 59 39 codon codon NN cord-256343-dtfw8o4g 59 40 , , , cord-256343-dtfw8o4g 59 41 which which WDT cord-256343-dtfw8o4g 59 42 was be VBD cord-256343-dtfw8o4g 59 43 used use VBN cord-256343-dtfw8o4g 59 44 to to TO cord-256343-dtfw8o4g 59 45 build build VB cord-256343-dtfw8o4g 59 46 a a DT cord-256343-dtfw8o4g 59 47 neighborjoining neighborjoine VBG cord-256343-dtfw8o4g 59 48 tree tree NN cord-256343-dtfw8o4g 59 49 ( ( -LRB- cord-256343-dtfw8o4g 59 50 1000 1000 CD cord-256343-dtfw8o4g 59 51 bootstrap bootstrap NN cord-256343-dtfw8o4g 59 52 replicates replicate NNS cord-256343-dtfw8o4g 59 53 ) ) -RRB- cord-256343-dtfw8o4g 59 54 using use VBG cord-256343-dtfw8o4g 59 55 PAUP PAUP NNP cord-256343-dtfw8o4g 59 56 , , , cord-256343-dtfw8o4g 59 57 version version NN cord-256343-dtfw8o4g 59 58 4.1b 4.1b CD cord-256343-dtfw8o4g 59 59 ( ( -LRB- cord-256343-dtfw8o4g 59 60 Swofford Swofford NNP cord-256343-dtfw8o4g 59 61 , , , cord-256343-dtfw8o4g 59 62 2000 2000 CD cord-256343-dtfw8o4g 59 63 ) ) -RRB- cord-256343-dtfw8o4g 59 64 . . . cord-256343-dtfw8o4g 60 1 The the DT cord-256343-dtfw8o4g 60 2 CAI CAI NNP cord-256343-dtfw8o4g 60 3 is be VBZ cord-256343-dtfw8o4g 60 4 a a DT cord-256343-dtfw8o4g 60 5 measure measure NN cord-256343-dtfw8o4g 60 6 of of IN cord-256343-dtfw8o4g 60 7 codon codon NN cord-256343-dtfw8o4g 60 8 usage usage NN cord-256343-dtfw8o4g 60 9 derived derive VBN cord-256343-dtfw8o4g 60 10 from from IN cord-256343-dtfw8o4g 60 11 the the DT cord-256343-dtfw8o4g 60 12 geometric geometric JJ cord-256343-dtfw8o4g 60 13 mean mean NN cord-256343-dtfw8o4g 60 14 of of IN cord-256343-dtfw8o4g 60 15 the the DT cord-256343-dtfw8o4g 60 16 relative relative JJ cord-256343-dtfw8o4g 60 17 codon codon NN cord-256343-dtfw8o4g 60 18 adaptiveness adaptiveness NN cord-256343-dtfw8o4g 60 19 for for IN cord-256343-dtfw8o4g 60 20 each each DT cord-256343-dtfw8o4g 60 21 codon codon NN cord-256343-dtfw8o4g 60 22 based base VBN cord-256343-dtfw8o4g 60 23 on on IN cord-256343-dtfw8o4g 60 24 a a DT cord-256343-dtfw8o4g 60 25 set set NN cord-256343-dtfw8o4g 60 26 of of IN cord-256343-dtfw8o4g 60 27 translationally translationally RB cord-256343-dtfw8o4g 60 28 optimal optimal JJ cord-256343-dtfw8o4g 60 29 codons codon NNS cord-256343-dtfw8o4g 60 30 used use VBN cord-256343-dtfw8o4g 60 31 as as IN cord-256343-dtfw8o4g 60 32 a a DT cord-256343-dtfw8o4g 60 33 reference reference NN cord-256343-dtfw8o4g 61 1 ( ( -LRB- cord-256343-dtfw8o4g 61 2 Roth Roth NNP cord-256343-dtfw8o4g 61 3 et et FW cord-256343-dtfw8o4g 61 4 al al NNP cord-256343-dtfw8o4g 61 5 . . NNP cord-256343-dtfw8o4g 61 6 , , , cord-256343-dtfw8o4g 61 7 2012 2012 CD cord-256343-dtfw8o4g 61 8 ) ) -RRB- cord-256343-dtfw8o4g 61 9 and and CC cord-256343-dtfw8o4g 61 10 can can MD cord-256343-dtfw8o4g 61 11 be be VB cord-256343-dtfw8o4g 61 12 calculated calculate VBN cord-256343-dtfw8o4g 61 13 according accord VBG cord-256343-dtfw8o4g 61 14 to to IN cord-256343-dtfw8o4g 61 15 the the DT cord-256343-dtfw8o4g 61 16 equation equation NN cord-256343-dtfw8o4g 61 17 Here here RB cord-256343-dtfw8o4g 62 1 , , , cord-256343-dtfw8o4g 62 2 w w NNP cord-256343-dtfw8o4g 62 3 k k NNP cord-256343-dtfw8o4g 62 4 is be VBZ cord-256343-dtfw8o4g 62 5 the the DT cord-256343-dtfw8o4g 62 6 relative relative JJ cord-256343-dtfw8o4g 62 7 adaptiveness adaptiveness NN cord-256343-dtfw8o4g 62 8 of of IN cord-256343-dtfw8o4g 62 9 the the DT cord-256343-dtfw8o4g 62 10 kth kth NNP cord-256343-dtfw8o4g 62 11 codon codon NN cord-256343-dtfw8o4g 62 12 ( ( -LRB- cord-256343-dtfw8o4g 62 13 61 61 CD cord-256343-dtfw8o4g 62 14 codons codon NNS cord-256343-dtfw8o4g 62 15 ; ; : cord-256343-dtfw8o4g 62 16 the the DT cord-256343-dtfw8o4g 62 17 three three CD cord-256343-dtfw8o4g 62 18 stop stop NN cord-256343-dtfw8o4g 62 19 codons codon NNS cord-256343-dtfw8o4g 62 20 were be VBD cord-256343-dtfw8o4g 62 21 excluded exclude VBN cord-256343-dtfw8o4g 62 22 ) ) -RRB- cord-256343-dtfw8o4g 62 23 , , , cord-256343-dtfw8o4g 62 24 and and CC cord-256343-dtfw8o4g 62 25 X X NNP cord-256343-dtfw8o4g 62 26 k k NNP cord-256343-dtfw8o4g 62 27 , , , cord-256343-dtfw8o4g 62 28 g g NNP cord-256343-dtfw8o4g 62 29 is be VBZ cord-256343-dtfw8o4g 62 30 the the DT cord-256343-dtfw8o4g 62 31 fraction fraction NN cord-256343-dtfw8o4g 62 32 of of IN cord-256343-dtfw8o4g 63 1 the the DT cord-256343-dtfw8o4g 63 2 codon codon NN cord-256343-dtfw8o4g 63 3 k k XX cord-256343-dtfw8o4g 63 4 relative relative NN cord-256343-dtfw8o4g 63 5 to to IN cord-256343-dtfw8o4g 63 6 the the DT cord-256343-dtfw8o4g 63 7 total total JJ cord-256343-dtfw8o4g 63 8 number number NN cord-256343-dtfw8o4g 63 9 of of IN cord-256343-dtfw8o4g 63 10 codons codon NNS cord-256343-dtfw8o4g 63 11 in in IN cord-256343-dtfw8o4g 63 12 the the DT cord-256343-dtfw8o4g 63 13 gene gene NN cord-256343-dtfw8o4g 63 14 . . . cord-256343-dtfw8o4g 64 1 Values value NNS cord-256343-dtfw8o4g 64 2 closer close RBR cord-256343-dtfw8o4g 64 3 to to IN cord-256343-dtfw8o4g 64 4 1 1 CD cord-256343-dtfw8o4g 64 5 indicate indicate VBP cord-256343-dtfw8o4g 64 6 a a DT cord-256343-dtfw8o4g 64 7 high high JJ cord-256343-dtfw8o4g 64 8 fitness fitness NN cord-256343-dtfw8o4g 64 9 in in IN cord-256343-dtfw8o4g 64 10 terms term NNS cord-256343-dtfw8o4g 64 11 of of IN cord-256343-dtfw8o4g 64 12 codon codon NN cord-256343-dtfw8o4g 64 13 usage usage NN cord-256343-dtfw8o4g 64 14 for for IN cord-256343-dtfw8o4g 64 15 a a DT cord-256343-dtfw8o4g 64 16 given give VBN cord-256343-dtfw8o4g 64 17 codon codon NN cord-256343-dtfw8o4g 64 18 sequence sequence NN cord-256343-dtfw8o4g 64 19 in in IN cord-256343-dtfw8o4g 64 20 relation relation NN cord-256343-dtfw8o4g 64 21 to to IN cord-256343-dtfw8o4g 64 22 the the DT cord-256343-dtfw8o4g 64 23 reference reference NN cord-256343-dtfw8o4g 64 24 system system NN cord-256343-dtfw8o4g 64 25 ( ( -LRB- cord-256343-dtfw8o4g 64 26 Sharp Sharp NNP cord-256343-dtfw8o4g 64 27 and and CC cord-256343-dtfw8o4g 64 28 Li Li NNP cord-256343-dtfw8o4g 64 29 , , , cord-256343-dtfw8o4g 64 30 1987 1987 CD cord-256343-dtfw8o4g 64 31 ) ) -RRB- cord-256343-dtfw8o4g 64 32 , , , cord-256343-dtfw8o4g 64 33 i.e. i.e. FW cord-256343-dtfw8o4g 64 34 , , , cord-256343-dtfw8o4g 64 35 a a DT cord-256343-dtfw8o4g 64 36 high high JJ cord-256343-dtfw8o4g 64 37 adaptation adaptation NN cord-256343-dtfw8o4g 64 38 of of IN cord-256343-dtfw8o4g 64 39 viral viral JJ cord-256343-dtfw8o4g 64 40 genes gene NNS cord-256343-dtfw8o4g 64 41 to to IN cord-256343-dtfw8o4g 64 42 the the DT cord-256343-dtfw8o4g 64 43 host host NN cord-256343-dtfw8o4g 64 44 . . . cord-256343-dtfw8o4g 65 1 The the DT cord-256343-dtfw8o4g 65 2 CAI CAI NNP cord-256343-dtfw8o4g 65 3 was be VBD cord-256343-dtfw8o4g 65 4 calculated calculate VBN cord-256343-dtfw8o4g 65 5 for for IN cord-256343-dtfw8o4g 65 6 sequences sequence NNS cord-256343-dtfw8o4g 65 7 from from IN cord-256343-dtfw8o4g 65 8 both both CC cord-256343-dtfw8o4g 65 9 A. a. NN cord-256343-dtfw8o4g 65 10 coronavirus coronavirus NN cord-256343-dtfw8o4g 65 11 and and CC cord-256343-dtfw8o4g 65 12 G. G. NNP cord-256343-dtfw8o4g 65 13 gallus gallus NN cord-256343-dtfw8o4g 65 14 using use VBG cord-256343-dtfw8o4g 65 15 a a DT cord-256343-dtfw8o4g 65 16 reference reference NN cord-256343-dtfw8o4g 65 17 set set VBN cord-256343-dtfw8o4g 65 18 of of IN cord-256343-dtfw8o4g 65 19 highly highly RB cord-256343-dtfw8o4g 65 20 expressed express VBN cord-256343-dtfw8o4g 65 21 G. G. NNP cord-256343-dtfw8o4g 65 22 gallus gallus NN cord-256343-dtfw8o4g 65 23 genes gene NNS cord-256343-dtfw8o4g 65 24 available available JJ cord-256343-dtfw8o4g 65 25 in in IN cord-256343-dtfw8o4g 65 26 the the DT cord-256343-dtfw8o4g 65 27 ACUA ACUA NNP cord-256343-dtfw8o4g 65 28 1.0 1.0 CD cord-256343-dtfw8o4g 65 29 software software NN cord-256343-dtfw8o4g 65 30 ( ( -LRB- cord-256343-dtfw8o4g 65 31 Vetrivel Vetrivel NNP cord-256343-dtfw8o4g 65 32 et et NNP cord-256343-dtfw8o4g 65 33 al al NNP cord-256343-dtfw8o4g 65 34 . . NNP cord-256343-dtfw8o4g 65 35 , , , cord-256343-dtfw8o4g 65 36 2007 2007 CD cord-256343-dtfw8o4g 65 37 ) ) -RRB- cord-256343-dtfw8o4g 65 38 . . . cord-256343-dtfw8o4g 66 1 Nc Nc NNP cord-256343-dtfw8o4g 66 2 is be VBZ cord-256343-dtfw8o4g 66 3 a a DT cord-256343-dtfw8o4g 66 4 measure measure NN cord-256343-dtfw8o4g 66 5 of of IN cord-256343-dtfw8o4g 66 6 the the DT cord-256343-dtfw8o4g 66 7 total total JJ cord-256343-dtfw8o4g 66 8 number number NN cord-256343-dtfw8o4g 66 9 of of IN cord-256343-dtfw8o4g 66 10 different different JJ cord-256343-dtfw8o4g 66 11 codons codon NNS cord-256343-dtfw8o4g 66 12 present present JJ cord-256343-dtfw8o4g 66 13 in in IN cord-256343-dtfw8o4g 66 14 a a DT cord-256343-dtfw8o4g 66 15 sequence sequence NN cord-256343-dtfw8o4g 66 16 and and CC cord-256343-dtfw8o4g 66 17 shows show VBZ cord-256343-dtfw8o4g 66 18 the the DT cord-256343-dtfw8o4g 66 19 bias bias NN cord-256343-dtfw8o4g 66 20 from from IN cord-256343-dtfw8o4g 66 21 equal equal JJ cord-256343-dtfw8o4g 66 22 use use NN cord-256343-dtfw8o4g 66 23 of of IN cord-256343-dtfw8o4g 66 24 all all DT cord-256343-dtfw8o4g 66 25 synonymous synonymous JJ cord-256343-dtfw8o4g 66 26 codons codon NNS cord-256343-dtfw8o4g 66 27 for for IN cord-256343-dtfw8o4g 66 28 a a DT cord-256343-dtfw8o4g 66 29 given give VBN cord-256343-dtfw8o4g 66 30 amino amino NN cord-256343-dtfw8o4g 66 31 acid acid NN cord-256343-dtfw8o4g 66 32 , , , cord-256343-dtfw8o4g 66 33 with with IN cord-256343-dtfw8o4g 66 34 each each DT cord-256343-dtfw8o4g 66 35 synonymous synonymous JJ cord-256343-dtfw8o4g 66 36 codon codon NN cord-256343-dtfw8o4g 66 37 treated treat VBN cord-256343-dtfw8o4g 66 38 as as IN cord-256343-dtfw8o4g 66 39 an an DT cord-256343-dtfw8o4g 66 40 allele allele NN cord-256343-dtfw8o4g 66 41 as as IN cord-256343-dtfw8o4g 66 42 in in IN cord-256343-dtfw8o4g 66 43 the the DT cord-256343-dtfw8o4g 66 44 calculation calculation NN cord-256343-dtfw8o4g 66 45 of of IN cord-256343-dtfw8o4g 66 46 the the DT cord-256343-dtfw8o4g 66 47 effective effective JJ cord-256343-dtfw8o4g 66 48 number number NN cord-256343-dtfw8o4g 66 49 of of IN cord-256343-dtfw8o4g 66 50 alleles allele NNS cord-256343-dtfw8o4g 66 51 in in IN cord-256343-dtfw8o4g 66 52 population population NN cord-256343-dtfw8o4g 66 53 genetics genetics NN cord-256343-dtfw8o4g 67 1 ( ( -LRB- cord-256343-dtfw8o4g 67 2 Roth Roth NNP cord-256343-dtfw8o4g 67 3 et et FW cord-256343-dtfw8o4g 67 4 al al NNP cord-256343-dtfw8o4g 67 5 . . NNP cord-256343-dtfw8o4g 67 6 , , , cord-256343-dtfw8o4g 67 7 2012 2012 CD cord-256343-dtfw8o4g 67 8 ) ) -RRB- cord-256343-dtfw8o4g 67 9 . . . cord-256343-dtfw8o4g 68 1 Nc Nc NNP cord-256343-dtfw8o4g 68 2 values value NNS cord-256343-dtfw8o4g 68 3 range range VBP cord-256343-dtfw8o4g 68 4 from from IN cord-256343-dtfw8o4g 68 5 20 20 CD cord-256343-dtfw8o4g 68 6 to to TO cord-256343-dtfw8o4g 68 7 61 61 CD cord-256343-dtfw8o4g 68 8 , , , cord-256343-dtfw8o4g 68 9 with with IN cord-256343-dtfw8o4g 68 10 values value NNS cord-256343-dtfw8o4g 68 11 closer close RBR cord-256343-dtfw8o4g 68 12 to to IN cord-256343-dtfw8o4g 68 13 61 61 CD cord-256343-dtfw8o4g 68 14 indicating indicate VBG cord-256343-dtfw8o4g 68 15 a a DT cord-256343-dtfw8o4g 68 16 lower low JJR cord-256343-dtfw8o4g 68 17 bias bias NN cord-256343-dtfw8o4g 68 18 ( ( -LRB- cord-256343-dtfw8o4g 68 19 Wright Wright NNP cord-256343-dtfw8o4g 68 20 , , , cord-256343-dtfw8o4g 68 21 1990 1990 CD cord-256343-dtfw8o4g 68 22 ) ) -RRB- cord-256343-dtfw8o4g 68 23 . . . cord-256343-dtfw8o4g 69 1 Nc Nc NNP cord-256343-dtfw8o4g 69 2 was be VBD cord-256343-dtfw8o4g 69 3 calculated calculate VBN cord-256343-dtfw8o4g 69 4 according accord VBG cord-256343-dtfw8o4g 69 5 to to IN cord-256343-dtfw8o4g 69 6 the the DT cord-256343-dtfw8o4g 69 7 equation equation NN cord-256343-dtfw8o4g 69 8 Nc Nc NNP cord-256343-dtfw8o4g 69 9 = = SYM cord-256343-dtfw8o4g 69 10 2 2 CD cord-256343-dtfw8o4g 69 11 + + SYM cord-256343-dtfw8o4g 69 12 ( ( -LRB- cord-256343-dtfw8o4g 69 13 9 9 CD cord-256343-dtfw8o4g 69 14 / / SYM cord-256343-dtfw8o4g 69 15 F2 F2 NNP cord-256343-dtfw8o4g 69 16 ) ) -RRB- cord-256343-dtfw8o4g 69 17 + + . cord-256343-dtfw8o4g 70 1 ( ( -LRB- cord-256343-dtfw8o4g 70 2 1 1 CD cord-256343-dtfw8o4g 70 3 / / SYM cord-256343-dtfw8o4g 70 4 F3 F3 NNP cord-256343-dtfw8o4g 70 5 ) ) -RRB- cord-256343-dtfw8o4g 71 1 + + CC cord-256343-dtfw8o4g 72 1 ( ( -LRB- cord-256343-dtfw8o4g 72 2 5 5 CD cord-256343-dtfw8o4g 72 3 / / SYM cord-256343-dtfw8o4g 72 4 F4 f4 NN cord-256343-dtfw8o4g 72 5 ) ) -RRB- cord-256343-dtfw8o4g 73 1 + + CC cord-256343-dtfw8o4g 73 2 ( ( -LRB- cord-256343-dtfw8o4g 73 3 3 3 CD cord-256343-dtfw8o4g 73 4 / / SYM cord-256343-dtfw8o4g 73 5 F6 F6 NNP cord-256343-dtfw8o4g 73 6 ) ) -RRB- cord-256343-dtfw8o4g 73 7 , , , cord-256343-dtfw8o4g 73 8 where where WRB cord-256343-dtfw8o4g 73 9 F F NNP cord-256343-dtfw8o4g 73 10 is be VBZ cord-256343-dtfw8o4g 73 11 the the DT cord-256343-dtfw8o4g 73 12 average average JJ cord-256343-dtfw8o4g 73 13 homozygosity homozygosity NN cord-256343-dtfw8o4g 73 14 for for IN cord-256343-dtfw8o4g 73 15 equal equal JJ cord-256343-dtfw8o4g 73 16 use use NN cord-256343-dtfw8o4g 73 17 of of IN cord-256343-dtfw8o4g 73 18 each each DT cord-256343-dtfw8o4g 73 19 synonymous synonymous JJ cord-256343-dtfw8o4g 73 20 codon codon NN cord-256343-dtfw8o4g 73 21 for for IN cord-256343-dtfw8o4g 73 22 each each DT cord-256343-dtfw8o4g 73 23 class class NN cord-256343-dtfw8o4g 73 24 of of IN cord-256343-dtfw8o4g 73 25 degeneracy degeneracy NN cord-256343-dtfw8o4g 73 26 ranging range VBG cord-256343-dtfw8o4g 73 27 from from IN cord-256343-dtfw8o4g 73 28 2 2 CD cord-256343-dtfw8o4g 73 29 to to IN cord-256343-dtfw8o4g 73 30 6 6 CD cord-256343-dtfw8o4g 73 31 , , , cord-256343-dtfw8o4g 73 32 using use VBG cord-256343-dtfw8o4g 73 33 ACUA ACUA NNP cord-256343-dtfw8o4g 73 34 1.0 1.0 CD cord-256343-dtfw8o4g 74 1 ( ( -LRB- cord-256343-dtfw8o4g 74 2 Vetrivel Vetrivel NNP cord-256343-dtfw8o4g 74 3 et et NNP cord-256343-dtfw8o4g 74 4 al al NNP cord-256343-dtfw8o4g 74 5 . . NNP cord-256343-dtfw8o4g 74 6 , , , cord-256343-dtfw8o4g 74 7 2007 2007 CD cord-256343-dtfw8o4g 74 8 ) ) -RRB- cord-256343-dtfw8o4g 74 9 . . . cord-256343-dtfw8o4g 75 1 The the DT cord-256343-dtfw8o4g 75 2 expected expect VBN cord-256343-dtfw8o4g 75 3 effective effective JJ cord-256343-dtfw8o4g 75 4 number number NN cord-256343-dtfw8o4g 75 5 of of IN cord-256343-dtfw8o4g 75 6 codons codon NNS cord-256343-dtfw8o4g 75 7 ( ( -LRB- cord-256343-dtfw8o4g 75 8 ENC ENC NNP cord-256343-dtfw8o4g 75 9 ) ) -RRB- cord-256343-dtfw8o4g 75 10 , , , cord-256343-dtfw8o4g 75 11 a a DT cord-256343-dtfw8o4g 75 12 measure measure NN cord-256343-dtfw8o4g 75 13 of of IN cord-256343-dtfw8o4g 75 14 codon codon NN cord-256343-dtfw8o4g 75 15 usage usage NN cord-256343-dtfw8o4g 75 16 affected affect VBN cord-256343-dtfw8o4g 75 17 only only RB cord-256343-dtfw8o4g 75 18 by by IN cord-256343-dtfw8o4g 75 19 the the DT cord-256343-dtfw8o4g 75 20 GC GC NNP cord-256343-dtfw8o4g 75 21 3 3 CD cord-256343-dtfw8o4g 75 22 % % NN cord-256343-dtfw8o4g 75 23 ( ( -LRB- cord-256343-dtfw8o4g 75 24 the the DT cord-256343-dtfw8o4g 75 25 percentage percentage NN cord-256343-dtfw8o4g 75 26 of of IN cord-256343-dtfw8o4g 75 27 G g NN cord-256343-dtfw8o4g 75 28 or or CC cord-256343-dtfw8o4g 75 29 C c NN cord-256343-dtfw8o4g 75 30 at at IN cord-256343-dtfw8o4g 75 31 the the DT cord-256343-dtfw8o4g 75 32 third third JJ cord-256343-dtfw8o4g 75 33 position position NN cord-256343-dtfw8o4g 75 34 of of IN cord-256343-dtfw8o4g 75 35 all all DT cord-256343-dtfw8o4g 75 36 codons codon NNS cord-256343-dtfw8o4g 75 37 in in IN cord-256343-dtfw8o4g 75 38 a a DT cord-256343-dtfw8o4g 75 39 sequence sequence NN cord-256343-dtfw8o4g 75 40 ) ) -RRB- cord-256343-dtfw8o4g 75 41 as as IN cord-256343-dtfw8o4g 75 42 a a DT cord-256343-dtfw8o4g 75 43 result result NN cord-256343-dtfw8o4g 75 44 of of IN cord-256343-dtfw8o4g 75 45 mutation mutation NN cord-256343-dtfw8o4g 75 46 pressure pressure NN cord-256343-dtfw8o4g 75 47 and and CC cord-256343-dtfw8o4g 75 48 drift drift NN cord-256343-dtfw8o4g 75 49 , , , cord-256343-dtfw8o4g 75 50 was be VBD cord-256343-dtfw8o4g 75 51 calculated calculate VBN cord-256343-dtfw8o4g 75 52 using use VBG cord-256343-dtfw8o4g 75 53 the the DT cord-256343-dtfw8o4g 75 54 equation equation NN cord-256343-dtfw8o4g 75 55 ENC ENC NNP cord-256343-dtfw8o4g 75 56 expec expec XX cord-256343-dtfw8o4g 75 57 = = SYM cord-256343-dtfw8o4g 75 58 2 2 CD cord-256343-dtfw8o4g 76 1 + + CC cord-256343-dtfw8o4g 76 2 s s NN cord-256343-dtfw8o4g 76 3 + + SYM cord-256343-dtfw8o4g 76 4 29[s 29[s CD cord-256343-dtfw8o4g 76 5 2 2 CD cord-256343-dtfw8o4g 76 6 + + CC cord-256343-dtfw8o4g 77 1 ( ( -LRB- cord-256343-dtfw8o4g 77 2 1 1 CD cord-256343-dtfw8o4g 77 3 − − NNP cord-256343-dtfw8o4g 77 4 s s NNP cord-256343-dtfw8o4g 77 5 ) ) -RRB- cord-256343-dtfw8o4g 77 6 2 2 CD cord-256343-dtfw8o4g 77 7 ] ] -RRB- cord-256343-dtfw8o4g 78 1 −1 −1 NNP cord-256343-dtfw8o4g 78 2 ( ( -LRB- cord-256343-dtfw8o4g 78 3 Wright Wright NNP cord-256343-dtfw8o4g 78 4 , , , cord-256343-dtfw8o4g 78 5 1990 1990 CD cord-256343-dtfw8o4g 78 6 ) ) -RRB- cord-256343-dtfw8o4g 78 7 , , , cord-256343-dtfw8o4g 78 8 where where WRB cord-256343-dtfw8o4g 78 9 s s NNP cord-256343-dtfw8o4g 78 10 is be VBZ cord-256343-dtfw8o4g 78 11 the the DT cord-256343-dtfw8o4g 78 12 GC GC NNP cord-256343-dtfw8o4g 78 13 3 3 CD cord-256343-dtfw8o4g 78 14 % % NN cord-256343-dtfw8o4g 78 15 ranging range VBG cord-256343-dtfw8o4g 78 16 from from IN cord-256343-dtfw8o4g 78 17 0 0 CD cord-256343-dtfw8o4g 78 18 to to IN cord-256343-dtfw8o4g 78 19 100 100 CD cord-256343-dtfw8o4g 78 20 % % NN cord-256343-dtfw8o4g 78 21 . . . cord-256343-dtfw8o4g 79 1 The the DT cord-256343-dtfw8o4g 79 2 ENC ENC NNP cord-256343-dtfw8o4g 79 3 and and CC cord-256343-dtfw8o4g 79 4 simulated simulate VBN cord-256343-dtfw8o4g 79 5 GC GC NNP cord-256343-dtfw8o4g 79 6 3 3 CD cord-256343-dtfw8o4g 79 7 % % NN cord-256343-dtfw8o4g 79 8 values value NNS cord-256343-dtfw8o4g 79 9 were be VBD cord-256343-dtfw8o4g 79 10 plotted plot VBN cord-256343-dtfw8o4g 79 11 as as IN cord-256343-dtfw8o4g 79 12 a a DT cord-256343-dtfw8o4g 79 13 curve curve NN cord-256343-dtfw8o4g 79 14 together together RB cord-256343-dtfw8o4g 79 15 with with IN cord-256343-dtfw8o4g 79 16 the the DT cord-256343-dtfw8o4g 79 17 Nc Nc NNP cord-256343-dtfw8o4g 79 18 and and CC cord-256343-dtfw8o4g 79 19 observed observe VBD cord-256343-dtfw8o4g 79 20 GC GC NNP cord-256343-dtfw8o4g 79 21 3 3 CD cord-256343-dtfw8o4g 79 22 % % NN cord-256343-dtfw8o4g 79 23 values value NNS cord-256343-dtfw8o4g 79 24 ; ; : cord-256343-dtfw8o4g 79 25 an an DT cord-256343-dtfw8o4g 79 26 Nc Nc NNP cord-256343-dtfw8o4g 79 27 × × NN cord-256343-dtfw8o4g 79 28 observed observe VBD cord-256343-dtfw8o4g 79 29 plot plot NN cord-256343-dtfw8o4g 79 30 lying lie VBG cord-256343-dtfw8o4g 79 31 on on IN cord-256343-dtfw8o4g 79 32 the the DT cord-256343-dtfw8o4g 79 33 ENC ENC NNP cord-256343-dtfw8o4g 79 34 × × NNP cord-256343-dtfw8o4g 79 35 simulated simulate VBN cord-256343-dtfw8o4g 79 36 curve curve NN cord-256343-dtfw8o4g 79 37 indicates indicate VBZ cord-256343-dtfw8o4g 79 38 genetic genetic JJ cord-256343-dtfw8o4g 79 39 drift drift NN cord-256343-dtfw8o4g 79 40 / / SYM cord-256343-dtfw8o4g 79 41 mutational mutational JJ cord-256343-dtfw8o4g 79 42 bias bias NN cord-256343-dtfw8o4g 79 43 , , , cord-256343-dtfw8o4g 79 44 while while IN cord-256343-dtfw8o4g 79 45 plots plot NNS cord-256343-dtfw8o4g 79 46 outside outside IN cord-256343-dtfw8o4g 79 47 the the DT cord-256343-dtfw8o4g 79 48 curve curve NN cord-256343-dtfw8o4g 79 49 indicate indicate VBP cord-256343-dtfw8o4g 79 50 natural natural JJ cord-256343-dtfw8o4g 79 51 selection selection NN cord-256343-dtfw8o4g 79 52 ( ( -LRB- cord-256343-dtfw8o4g 79 53 Wright Wright NNP cord-256343-dtfw8o4g 79 54 , , , cord-256343-dtfw8o4g 79 55 1990 1990 CD cord-256343-dtfw8o4g 79 56 ) ) -RRB- cord-256343-dtfw8o4g 79 57 . . . cord-256343-dtfw8o4g 80 1 To to TO cord-256343-dtfw8o4g 80 2 assess assess VB cord-256343-dtfw8o4g 80 3 the the DT cord-256343-dtfw8o4g 80 4 significance significance NN cord-256343-dtfw8o4g 80 5 of of IN cord-256343-dtfw8o4g 80 6 each each DT cord-256343-dtfw8o4g 80 7 preferred preferred JJ cord-256343-dtfw8o4g 80 8 codon codon NN cord-256343-dtfw8o4g 80 9 on on IN cord-256343-dtfw8o4g 80 10 the the DT cord-256343-dtfw8o4g 80 11 molecular molecular JJ cord-256343-dtfw8o4g 80 12 evolution evolution NN cord-256343-dtfw8o4g 80 13 of of IN cord-256343-dtfw8o4g 80 14 A. a. NN cord-256343-dtfw8o4g 80 15 coronavirus coronavirus NN cord-256343-dtfw8o4g 80 16 , , , cord-256343-dtfw8o4g 80 17 100 100 CD cord-256343-dtfw8o4g 80 18 % % NN cord-256343-dtfw8o4g 80 19 conserved conserve VBN cord-256343-dtfw8o4g 80 20 amino amino NN cord-256343-dtfw8o4g 80 21 acid acid NN cord-256343-dtfw8o4g 80 22 positions position NNS cord-256343-dtfw8o4g 80 23 coded code VBN cord-256343-dtfw8o4g 80 24 by by IN cord-256343-dtfw8o4g 80 25 the the DT cord-256343-dtfw8o4g 80 26 preferred prefer VBN cord-256343-dtfw8o4g 80 27 codon(s codon(s NNP cord-256343-dtfw8o4g 80 28 ) ) -RRB- cord-256343-dtfw8o4g 80 29 , , , cord-256343-dtfw8o4g 80 30 i.e. i.e. FW cord-256343-dtfw8o4g 80 31 , , , cord-256343-dtfw8o4g 80 32 those those DT cord-256343-dtfw8o4g 80 33 with with IN cord-256343-dtfw8o4g 80 34 RSCUs rscu NNS cord-256343-dtfw8o4g 80 35 > > XX cord-256343-dtfw8o4g 80 36 1 1 CD cord-256343-dtfw8o4g 80 37 , , , cord-256343-dtfw8o4g 80 38 were be VBD cord-256343-dtfw8o4g 80 39 counted count VBN cord-256343-dtfw8o4g 80 40 for for IN cord-256343-dtfw8o4g 80 41 each each DT cord-256343-dtfw8o4g 80 42 gene gene NN cord-256343-dtfw8o4g 80 43 , , , cord-256343-dtfw8o4g 80 44 and and CC cord-256343-dtfw8o4g 80 45 the the DT cord-256343-dtfw8o4g 80 46 significance significance NN cord-256343-dtfw8o4g 80 47 of of IN cord-256343-dtfw8o4g 80 48 the the DT cord-256343-dtfw8o4g 80 49 differences difference NNS cord-256343-dtfw8o4g 80 50 was be VBD cord-256343-dtfw8o4g 80 51 assessed assess VBN cord-256343-dtfw8o4g 80 52 with with IN cord-256343-dtfw8o4g 80 53 Fisher Fisher NNP cord-256343-dtfw8o4g 80 54 's 's POS cord-256343-dtfw8o4g 80 55 exact exact JJ cord-256343-dtfw8o4g 80 56 test test NN cord-256343-dtfw8o4g 80 57 and and CC cord-256343-dtfw8o4g 80 58 the the DT cord-256343-dtfw8o4g 80 59 odds odd NNS cord-256343-dtfw8o4g 80 60 ratio ratio NN cord-256343-dtfw8o4g 80 61 ( ( -LRB- cord-256343-dtfw8o4g 80 62 OR OR NNP cord-256343-dtfw8o4g 80 63 ) ) -RRB- cord-256343-dtfw8o4g 80 64 . . . cord-256343-dtfw8o4g 81 1 To to TO cord-256343-dtfw8o4g 81 2 understand understand VB cord-256343-dtfw8o4g 81 3 the the DT cord-256343-dtfw8o4g 81 4 relationship relationship NN cord-256343-dtfw8o4g 81 5 between between IN cord-256343-dtfw8o4g 81 6 codon codon NN cord-256343-dtfw8o4g 81 7 and and CC cord-256343-dtfw8o4g 81 8 protein protein NN cord-256343-dtfw8o4g 81 9 selection selection NN cord-256343-dtfw8o4g 81 10 , , , cord-256343-dtfw8o4g 81 11 the the DT cord-256343-dtfw8o4g 81 12 occurrence occurrence NN cord-256343-dtfw8o4g 81 13 of of IN cord-256343-dtfw8o4g 81 14 purifying purify VBG cord-256343-dtfw8o4g 81 15 or or CC cord-256343-dtfw8o4g 81 16 positive positive JJ cord-256343-dtfw8o4g 81 17 selection selection NN cord-256343-dtfw8o4g 81 18 on on IN cord-256343-dtfw8o4g 81 19 A. a. NN cord-256343-dtfw8o4g 81 20 coronavirus coronavirus NN cord-256343-dtfw8o4g 81 21 S S NNP cord-256343-dtfw8o4g 81 22 , , , cord-256343-dtfw8o4g 81 23 N N NNP cord-256343-dtfw8o4g 81 24 , , , cord-256343-dtfw8o4g 81 25 NSP2 NSP2 NNP cord-256343-dtfw8o4g 81 26 and and CC cord-256343-dtfw8o4g 81 27 PL PL NNP cord-256343-dtfw8o4g 81 28 pro pro JJ cord-256343-dtfw8o4g 81 29 sequences sequence NNS cord-256343-dtfw8o4g 81 30 was be VBD cord-256343-dtfw8o4g 81 31 tested test VBN cord-256343-dtfw8o4g 81 32 with with IN cord-256343-dtfw8o4g 81 33 Fisher Fisher NNP cord-256343-dtfw8o4g 81 34 's 's POS cord-256343-dtfw8o4g 81 35 exact exact JJ cord-256343-dtfw8o4g 81 36 test test NN cord-256343-dtfw8o4g 81 37 of of IN cord-256343-dtfw8o4g 81 38 neutrality neutrality NN cord-256343-dtfw8o4g 81 39 for for IN cord-256343-dtfw8o4g 81 40 sequence sequence NN cord-256343-dtfw8o4g 81 41 pairs pair NNS cord-256343-dtfw8o4g 81 42 using use VBG cord-256343-dtfw8o4g 81 43 the the DT cord-256343-dtfw8o4g 81 44 Nei Nei NNP cord-256343-dtfw8o4g 81 45 - - HYPH cord-256343-dtfw8o4g 81 46 Gojobori Gojobori NNP cord-256343-dtfw8o4g 81 47 method method NN cord-256343-dtfw8o4g 81 48 ( ( -LRB- cord-256343-dtfw8o4g 81 49 Nei Nei NNP cord-256343-dtfw8o4g 81 50 and and CC cord-256343-dtfw8o4g 81 51 Gojobori Gojobori NNP cord-256343-dtfw8o4g 81 52 , , , cord-256343-dtfw8o4g 81 53 1986 1986 CD cord-256343-dtfw8o4g 81 54 ) ) -RRB- cord-256343-dtfw8o4g 81 55 for for IN cord-256343-dtfw8o4g 81 56 the the DT cord-256343-dtfw8o4g 81 57 difference difference NN cord-256343-dtfw8o4g 81 58 between between IN cord-256343-dtfw8o4g 81 59 the the DT cord-256343-dtfw8o4g 81 60 synonymous synonymous JJ cord-256343-dtfw8o4g 81 61 and and CC cord-256343-dtfw8o4g 81 62 non non JJ cord-256343-dtfw8o4g 81 63 - - JJ cord-256343-dtfw8o4g 81 64 synonymous synonymous JJ cord-256343-dtfw8o4g 81 65 substitution substitution NN cord-256343-dtfw8o4g 81 66 distances distance NNS cord-256343-dtfw8o4g 81 67 ( ( -LRB- cord-256343-dtfw8o4g 81 68 dS dS NNP cord-256343-dtfw8o4g 81 69 - - HYPH cord-256343-dtfw8o4g 81 70 dN dN NNP cord-256343-dtfw8o4g 81 71 ) ) -RRB- cord-256343-dtfw8o4g 81 72 using use VBG cord-256343-dtfw8o4g 81 73 Mega Mega NNP cord-256343-dtfw8o4g 81 74 5 5 CD cord-256343-dtfw8o4g 81 75 ( ( -LRB- cord-256343-dtfw8o4g 81 76 Tamura Tamura NNP cord-256343-dtfw8o4g 81 77 et et NNP cord-256343-dtfw8o4g 81 78 al al NNP cord-256343-dtfw8o4g 81 79 . . NNP cord-256343-dtfw8o4g 81 80 , , , cord-256343-dtfw8o4g 81 81 2011 2011 CD cord-256343-dtfw8o4g 81 82 ) ) -RRB- cord-256343-dtfw8o4g 81 83 . . . cord-256343-dtfw8o4g 82 1 Fig Fig NNP cord-256343-dtfw8o4g 82 2 . . NNP cord-256343-dtfw8o4g 82 3 1 1 CD cord-256343-dtfw8o4g 82 4 shows show VBZ cord-256343-dtfw8o4g 82 5 that that IN cord-256343-dtfw8o4g 82 6 G. G. NNP cord-256343-dtfw8o4g 82 7 gallus gallus NN cord-256343-dtfw8o4g 82 8 RSCUs rscu NNS cord-256343-dtfw8o4g 82 9 segregate segregate VBP cord-256343-dtfw8o4g 82 10 in in IN cord-256343-dtfw8o4g 82 11 a a DT cord-256343-dtfw8o4g 82 12 tissue tissue NN cord-256343-dtfw8o4g 82 13 - - HYPH cord-256343-dtfw8o4g 82 14 specific specific JJ cord-256343-dtfw8o4g 82 15 manner manner NN cord-256343-dtfw8o4g 82 16 in in IN cord-256343-dtfw8o4g 82 17 a a DT cord-256343-dtfw8o4g 82 18 topology topology NN cord-256343-dtfw8o4g 82 19 supported support VBN cord-256343-dtfw8o4g 82 20 by by IN cord-256343-dtfw8o4g 82 21 bootstrap bootstrap NN cord-256343-dtfw8o4g 82 22 values value NNS cord-256343-dtfw8o4g 82 23 of of IN cord-256343-dtfw8o4g 82 24 100 100 CD cord-256343-dtfw8o4g 82 25 for for IN cord-256343-dtfw8o4g 82 26 each each DT cord-256343-dtfw8o4g 82 27 gene gene NN cord-256343-dtfw8o4g 82 28 analyzed analyze VBN cord-256343-dtfw8o4g 82 29 . . . cord-256343-dtfw8o4g 83 1 Fig Fig NNP cord-256343-dtfw8o4g 83 2 . . . cord-256343-dtfw8o4g 84 1 1 1 LS cord-256343-dtfw8o4g 84 2 . . . cord-256343-dtfw8o4g 85 1 Neighbor neighbor NN cord-256343-dtfw8o4g 85 2 - - HYPH cord-256343-dtfw8o4g 85 3 joining join VBG cord-256343-dtfw8o4g 85 4 distance distance NN cord-256343-dtfw8o4g 85 5 tree tree NN cord-256343-dtfw8o4g 85 6 for for IN cord-256343-dtfw8o4g 85 7 the the DT cord-256343-dtfw8o4g 85 8 relative relative JJ cord-256343-dtfw8o4g 85 9 synonymous synonymous JJ cord-256343-dtfw8o4g 85 10 codon codon NN cord-256343-dtfw8o4g 85 11 usage usage NN cord-256343-dtfw8o4g 85 12 ( ( -LRB- cord-256343-dtfw8o4g 85 13 RSCU RSCU NNP cord-256343-dtfw8o4g 85 14 ) ) -RRB- cord-256343-dtfw8o4g 85 15 for for IN cord-256343-dtfw8o4g 85 16 the the DT cord-256343-dtfw8o4g 85 17 Avian avian JJ cord-256343-dtfw8o4g 85 18 coronavirus coronavirus NN cord-256343-dtfw8o4g 85 19 spike spike NN cord-256343-dtfw8o4g 85 20 ( ( -LRB- cord-256343-dtfw8o4g 85 21 S S NNP cord-256343-dtfw8o4g 85 22 ) ) -RRB- cord-256343-dtfw8o4g 85 23 , , , cord-256343-dtfw8o4g 85 24 nucleocapsid nucleocapsid NN cord-256343-dtfw8o4g 85 25 ( ( -LRB- cord-256343-dtfw8o4g 85 26 N N NNP cord-256343-dtfw8o4g 85 27 ) ) -RRB- cord-256343-dtfw8o4g 85 28 , , , cord-256343-dtfw8o4g 85 29 non non JJ cord-256343-dtfw8o4g 85 30 - - JJ cord-256343-dtfw8o4g 85 31 structural structural JJ cord-256343-dtfw8o4g 85 32 protein protein NN cord-256343-dtfw8o4g 85 33 2 2 CD cord-256343-dtfw8o4g 85 34 ( ( -LRB- cord-256343-dtfw8o4g 85 35 NSP2 NSP2 NNP cord-256343-dtfw8o4g 85 36 ) ) -RRB- cord-256343-dtfw8o4g 85 37 and and CC cord-256343-dtfw8o4g 85 38 papain papain NN cord-256343-dtfw8o4g 85 39 - - HYPH cord-256343-dtfw8o4g 85 40 like like JJ cord-256343-dtfw8o4g 85 41 protease protease NN cord-256343-dtfw8o4g 85 42 ( ( -LRB- cord-256343-dtfw8o4g 85 43 PL pl NN cord-256343-dtfw8o4g 85 44 pro pro FW cord-256343-dtfw8o4g 85 45 ) ) -RRB- cord-256343-dtfw8o4g 85 46 genes gene NNS cord-256343-dtfw8o4g 85 47 and and CC cord-256343-dtfw8o4g 85 48 the the DT cord-256343-dtfw8o4g 85 49 Gallus Gallus NNP cord-256343-dtfw8o4g 85 50 gallus gallus NN cord-256343-dtfw8o4g 85 51 beta beta NN cord-256343-dtfw8o4g 85 52 - - HYPH cord-256343-dtfw8o4g 85 53 actin actin JJ cord-256343-dtfw8o4g 85 54 , , , cord-256343-dtfw8o4g 85 55 lung lung NN cord-256343-dtfw8o4g 85 56 surfactant surfactant NN cord-256343-dtfw8o4g 85 57 protein protein NN cord-256343-dtfw8o4g 85 58 A A NNP cord-256343-dtfw8o4g 85 59 ( ( -LRB- cord-256343-dtfw8o4g 85 60 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 85 61 , , , cord-256343-dtfw8o4g 85 62 gray gray JJ cord-256343-dtfw8o4g 85 63 background background NN cord-256343-dtfw8o4g 85 64 ) ) -RRB- cord-256343-dtfw8o4g 85 65 , , , cord-256343-dtfw8o4g 85 66 intestinal intestinal JJ cord-256343-dtfw8o4g 85 67 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 85 68 ( ( -LRB- cord-256343-dtfw8o4g 85 69 CCK CCK NNP cord-256343-dtfw8o4g 85 70 ) ) -RRB- cord-256343-dtfw8o4g 85 71 , , , cord-256343-dtfw8o4g 85 72 oviduct oviduct NN cord-256343-dtfw8o4g 85 73 ovomucin ovomucin NNP cord-256343-dtfw8o4g 85 74 alpha alpha NNP cord-256343-dtfw8o4g 85 75 subunit subunit NNP cord-256343-dtfw8o4g 85 76 ( ( -LRB- cord-256343-dtfw8o4g 85 77 OSA OSA NNP cord-256343-dtfw8o4g 85 78 ) ) -RRB- cord-256343-dtfw8o4g 85 79 and and CC cord-256343-dtfw8o4g 85 80 kidney kidney NN cord-256343-dtfw8o4g 85 81 vitamin vitamin NN cord-256343-dtfw8o4g 85 82 D D NNP cord-256343-dtfw8o4g 85 83 receptor receptor NN cord-256343-dtfw8o4g 85 84 genes gene NNS cord-256343-dtfw8o4g 85 85 . . . cord-256343-dtfw8o4g 86 1 The the DT cord-256343-dtfw8o4g 86 2 tree tree NN cord-256343-dtfw8o4g 86 3 was be VBD cord-256343-dtfw8o4g 86 4 based base VBN cord-256343-dtfw8o4g 86 5 on on IN cord-256343-dtfw8o4g 86 6 binary binary JJ cord-256343-dtfw8o4g 86 7 data datum NNS cord-256343-dtfw8o4g 86 8 using use VBG cord-256343-dtfw8o4g 86 9 the the DT cord-256343-dtfw8o4g 86 10 value value NN cord-256343-dtfw8o4g 86 11 1 1 CD cord-256343-dtfw8o4g 86 12 for for IN cord-256343-dtfw8o4g 86 13 RSCUs rscu NNS cord-256343-dtfw8o4g 86 14 > > XX cord-256343-dtfw8o4g 87 1 1 1 LS cord-256343-dtfw8o4g 87 2 ( ( -LRB- cord-256343-dtfw8o4g 87 3 codon codon NN cord-256343-dtfw8o4g 87 4 is be VBZ cord-256343-dtfw8o4g 87 5 preferred prefer VBN cord-256343-dtfw8o4g 87 6 ) ) -RRB- cord-256343-dtfw8o4g 87 7 or or CC cord-256343-dtfw8o4g 87 8 0 0 CD cord-256343-dtfw8o4g 87 9 for for IN cord-256343-dtfw8o4g 87 10 RSCUs RSCUs NNP cord-256343-dtfw8o4g 87 11 ≤ ≤ NNP cord-256343-dtfw8o4g 87 12 1 1 CD cord-256343-dtfw8o4g 87 13 when when WRB cord-256343-dtfw8o4g 87 14 the the DT cord-256343-dtfw8o4g 87 15 codon codon NN cord-256343-dtfw8o4g 87 16 is be VBZ cord-256343-dtfw8o4g 87 17 not not RB cord-256343-dtfw8o4g 87 18 preferred prefer VBN cord-256343-dtfw8o4g 87 19 ( ( -LRB- cord-256343-dtfw8o4g 87 20 RSCU RSCU NNP cord-256343-dtfw8o4g 87 21 < < XX cord-256343-dtfw8o4g 87 22 1 1 CD cord-256343-dtfw8o4g 87 23 ) ) -RRB- cord-256343-dtfw8o4g 87 24 or or CC cord-256343-dtfw8o4g 87 25 is be VBZ cord-256343-dtfw8o4g 87 26 neutral neutral JJ cord-256343-dtfw8o4g 87 27 ( ( -LRB- cord-256343-dtfw8o4g 87 28 RSCU RSCU NNP cord-256343-dtfw8o4g 87 29 = = SYM cord-256343-dtfw8o4g 87 30 1 1 CD cord-256343-dtfw8o4g 87 31 ) ) -RRB- cord-256343-dtfw8o4g 87 32 . . . cord-256343-dtfw8o4g 88 1 ENC ENC NNP cord-256343-dtfw8o4g 88 2 ( ( -LRB- cord-256343-dtfw8o4g 88 3 effective effective JJ cord-256343-dtfw8o4g 88 4 number number NN cord-256343-dtfw8o4g 88 5 of of IN cord-256343-dtfw8o4g 88 6 codons codon NNS cord-256343-dtfw8o4g 88 7 ) ) -RRB- cord-256343-dtfw8o4g 88 8 values value VBZ cord-256343-dtfw8o4g 88 9 < < XX cord-256343-dtfw8o4g 88 10 40 40 CD cord-256343-dtfw8o4g 88 11 and and CC cord-256343-dtfw8o4g 88 12 > > XX cord-256343-dtfw8o4g 88 13 45 45 CD cord-256343-dtfw8o4g 88 14 are be VBP cord-256343-dtfw8o4g 88 15 marked mark VBN cord-256343-dtfw8o4g 88 16 with with IN cord-256343-dtfw8o4g 88 17 an an DT cord-256343-dtfw8o4g 88 18 asterisk asterisk NN cord-256343-dtfw8o4g 88 19 and and CC cord-256343-dtfw8o4g 88 20 a a DT cord-256343-dtfw8o4g 88 21 hash hash NN cord-256343-dtfw8o4g 88 22 , , , cord-256343-dtfw8o4g 88 23 respectively respectively RB cord-256343-dtfw8o4g 88 24 ; ; : cord-256343-dtfw8o4g 88 25 sequences sequence NNS cord-256343-dtfw8o4g 88 26 with with IN cord-256343-dtfw8o4g 88 27 ENC ENC NNP cord-256343-dtfw8o4g 88 28 values value NNS cord-256343-dtfw8o4g 88 29 between between IN cord-256343-dtfw8o4g 88 30 40 40 CD cord-256343-dtfw8o4g 88 31 and and CC cord-256343-dtfw8o4g 88 32 45 45 CD cord-256343-dtfw8o4g 88 33 have have VBP cord-256343-dtfw8o4g 88 34 no no DT cord-256343-dtfw8o4g 88 35 marks mark NNS cord-256343-dtfw8o4g 88 36 . . . cord-256343-dtfw8o4g 89 1 The the DT cord-256343-dtfw8o4g 89 2 arrow arrow NN cord-256343-dtfw8o4g 89 3 indicates indicate VBZ cord-256343-dtfw8o4g 89 4 the the DT cord-256343-dtfw8o4g 89 5 separation separation NN cord-256343-dtfw8o4g 89 6 between between IN cord-256343-dtfw8o4g 89 7 G. G. NNP cord-256343-dtfw8o4g 89 8 gallus gallus NN cord-256343-dtfw8o4g 89 9 and and CC cord-256343-dtfw8o4g 89 10 Avian avian JJ cord-256343-dtfw8o4g 89 11 coronavirus coronavirus NN cord-256343-dtfw8o4g 89 12 clusters cluster NNS cord-256343-dtfw8o4g 89 13 . . . cord-256343-dtfw8o4g 90 1 Numbers number NNS cord-256343-dtfw8o4g 90 2 at at IN cord-256343-dtfw8o4g 90 3 each each DT cord-256343-dtfw8o4g 90 4 node node NN cord-256343-dtfw8o4g 90 5 are be VBP cord-256343-dtfw8o4g 90 6 bootstrap bootstrap NN cord-256343-dtfw8o4g 90 7 values value NNS cord-256343-dtfw8o4g 90 8 ( ( -LRB- cord-256343-dtfw8o4g 90 9 1000 1000 CD cord-256343-dtfw8o4g 90 10 replicates replicate NNS cord-256343-dtfw8o4g 90 11 , , , cord-256343-dtfw8o4g 90 12 only only RB cord-256343-dtfw8o4g 90 13 values value NNS cord-256343-dtfw8o4g 90 14 > > XX cord-256343-dtfw8o4g 90 15 50 50 CD cord-256343-dtfw8o4g 90 16 are be VBP cord-256343-dtfw8o4g 90 17 shown show VBN cord-256343-dtfw8o4g 90 18 ) ) -RRB- cord-256343-dtfw8o4g 90 19 . . . cord-256343-dtfw8o4g 91 1 The the DT cord-256343-dtfw8o4g 91 2 bar bar NN cord-256343-dtfw8o4g 91 3 represents represent VBZ cord-256343-dtfw8o4g 91 4 the the DT cord-256343-dtfw8o4g 91 5 codon codon NN cord-256343-dtfw8o4g 91 6 usage usage NN cord-256343-dtfw8o4g 91 7 preferences preference NNS cord-256343-dtfw8o4g 91 8 distance distance NN cord-256343-dtfw8o4g 91 9 . . . cord-256343-dtfw8o4g 92 1 For for IN cord-256343-dtfw8o4g 92 2 the the DT cord-256343-dtfw8o4g 92 3 A. a. JJ cord-256343-dtfw8o4g 92 4 coronavirus coronavirus NN cord-256343-dtfw8o4g 92 5 RSCUs rscus NN cord-256343-dtfw8o4g 92 6 , , , cord-256343-dtfw8o4g 92 7 all all DT cord-256343-dtfw8o4g 92 8 genes gene NNS cord-256343-dtfw8o4g 92 9 segregated segregate VBN cord-256343-dtfw8o4g 92 10 in in IN cord-256343-dtfw8o4g 92 11 genespecific genespecific JJ cord-256343-dtfw8o4g 92 12 clusters cluster NNS cord-256343-dtfw8o4g 92 13 , , , cord-256343-dtfw8o4g 92 14 except except IN cord-256343-dtfw8o4g 92 15 for for IN cord-256343-dtfw8o4g 92 16 the the DT cord-256343-dtfw8o4g 92 17 sequence sequence NN cord-256343-dtfw8o4g 92 18 EU526388.1 EU526388.1 NNP cord-256343-dtfw8o4g 92 19 A2 A2 NNP cord-256343-dtfw8o4g 92 20 PL PL NNP cord-256343-dtfw8o4g 92 21 pro pro NNP cord-256343-dtfw8o4g 92 22 , , , cord-256343-dtfw8o4g 92 23 which which WDT cord-256343-dtfw8o4g 92 24 segregated segregate VBD cord-256343-dtfw8o4g 92 25 closer close RBR cord-256343-dtfw8o4g 92 26 to to IN cord-256343-dtfw8o4g 92 27 the the DT cord-256343-dtfw8o4g 92 28 NSP2 NSP2 NNP cord-256343-dtfw8o4g 92 29 cluster cluster NN cord-256343-dtfw8o4g 92 30 . . . cord-256343-dtfw8o4g 93 1 All all DT cord-256343-dtfw8o4g 93 2 strains strain NNS cord-256343-dtfw8o4g 93 3 segregated segregate VBN cord-256343-dtfw8o4g 93 4 in in IN cord-256343-dtfw8o4g 93 5 a a DT cord-256343-dtfw8o4g 93 6 cluster cluster NN cord-256343-dtfw8o4g 93 7 separated separate VBN cord-256343-dtfw8o4g 93 8 from from IN cord-256343-dtfw8o4g 93 9 G. G. NNP cord-256343-dtfw8o4g 93 10 gallus gallus NN cord-256343-dtfw8o4g 93 11 , , , cord-256343-dtfw8o4g 93 12 with with IN cord-256343-dtfw8o4g 93 13 the the DT cord-256343-dtfw8o4g 93 14 internal internal JJ cord-256343-dtfw8o4g 93 15 nodes node NNS cord-256343-dtfw8o4g 93 16 resulting result VBG cord-256343-dtfw8o4g 93 17 in in IN cord-256343-dtfw8o4g 93 18 the the DT cord-256343-dtfw8o4g 93 19 genotype genotype NN cord-256343-dtfw8o4g 93 20 - - HYPH cord-256343-dtfw8o4g 93 21 specific specific JJ cord-256343-dtfw8o4g 93 22 sub sub NN cord-256343-dtfw8o4g 93 23 - - NNS cord-256343-dtfw8o4g 93 24 clusters cluster NNS cord-256343-dtfw8o4g 93 25 for for IN cord-256343-dtfw8o4g 93 26 the the DT cord-256343-dtfw8o4g 93 27 S S NNP cord-256343-dtfw8o4g 93 28 gene gene NN cord-256343-dtfw8o4g 93 29 , , , cord-256343-dtfw8o4g 93 30 including include VBG cord-256343-dtfw8o4g 93 31 those those DT cord-256343-dtfw8o4g 93 32 for for IN cord-256343-dtfw8o4g 93 33 the the DT cord-256343-dtfw8o4g 93 34 archetypes archetype NNS cord-256343-dtfw8o4g 93 35 Connecticut Connecticut NNP cord-256343-dtfw8o4g 93 36 , , , cord-256343-dtfw8o4g 93 37 Massachusetts Massachusetts NNP cord-256343-dtfw8o4g 93 38 and and CC cord-256343-dtfw8o4g 93 39 Arkansas Arkansas NNP cord-256343-dtfw8o4g 93 40 , , , cord-256343-dtfw8o4g 93 41 with with IN cord-256343-dtfw8o4g 93 42 two two CD cord-256343-dtfw8o4g 93 43 sub sub NN cord-256343-dtfw8o4g 93 44 clusters cluster NNS cord-256343-dtfw8o4g 93 45 and and CC cord-256343-dtfw8o4g 93 46 the the DT cord-256343-dtfw8o4g 93 47 PL pl NN cord-256343-dtfw8o4g 93 48 pro pro NN cord-256343-dtfw8o4g 93 49 cluster cluster NN cord-256343-dtfw8o4g 93 50 between between IN cord-256343-dtfw8o4g 93 51 them -PRON- PRP cord-256343-dtfw8o4g 93 52 . . . cord-256343-dtfw8o4g 94 1 No no DT cord-256343-dtfw8o4g 94 2 pathotype pathotype RB cord-256343-dtfw8o4g 94 3 - - HYPH cord-256343-dtfw8o4g 94 4 specific specific JJ cord-256343-dtfw8o4g 94 5 cluster cluster NN cord-256343-dtfw8o4g 94 6 was be VBD cord-256343-dtfw8o4g 94 7 found find VBN cord-256343-dtfw8o4g 94 8 . . . cord-256343-dtfw8o4g 95 1 Though though IN cord-256343-dtfw8o4g 95 2 the the DT cord-256343-dtfw8o4g 95 3 distinction distinction NN cord-256343-dtfw8o4g 95 4 between between IN cord-256343-dtfw8o4g 95 5 the the DT cord-256343-dtfw8o4g 95 6 A. a. JJ cord-256343-dtfw8o4g 95 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 95 8 and and CC cord-256343-dtfw8o4g 95 9 G. G. NNP cord-256343-dtfw8o4g 95 10 gallus gallus NN cord-256343-dtfw8o4g 95 11 RSCUs rscus NN cord-256343-dtfw8o4g 95 12 clusters cluster NNS cord-256343-dtfw8o4g 95 13 is be VBZ cord-256343-dtfw8o4g 95 14 also also RB cord-256343-dtfw8o4g 95 15 clear clear JJ cord-256343-dtfw8o4g 95 16 for for IN cord-256343-dtfw8o4g 95 17 the the DT cord-256343-dtfw8o4g 95 18 N N NNP cord-256343-dtfw8o4g 95 19 , , , cord-256343-dtfw8o4g 95 20 NSP2 NSP2 NNP cord-256343-dtfw8o4g 95 21 and and CC cord-256343-dtfw8o4g 95 22 PL PL NNP cord-256343-dtfw8o4g 95 23 pro pro JJ cord-256343-dtfw8o4g 95 24 genes gene NNS cord-256343-dtfw8o4g 95 25 , , , cord-256343-dtfw8o4g 95 26 a a DT cord-256343-dtfw8o4g 95 27 less less RBR cord-256343-dtfw8o4g 95 28 resolved resolve VBN cord-256343-dtfw8o4g 95 29 topology topology NN cord-256343-dtfw8o4g 95 30 emerges emerge VBZ cord-256343-dtfw8o4g 95 31 because because IN cord-256343-dtfw8o4g 95 32 the the DT cord-256343-dtfw8o4g 95 33 distinction distinction NN cord-256343-dtfw8o4g 95 34 among among IN cord-256343-dtfw8o4g 95 35 the the DT cord-256343-dtfw8o4g 95 36 different different JJ cord-256343-dtfw8o4g 95 37 genotypes genotype NNS cord-256343-dtfw8o4g 95 38 is be VBZ cord-256343-dtfw8o4g 95 39 not not RB cord-256343-dtfw8o4g 95 40 sustained sustain VBN cord-256343-dtfw8o4g 95 41 . . . cord-256343-dtfw8o4g 96 1 For for IN cord-256343-dtfw8o4g 96 2 all all DT cord-256343-dtfw8o4g 96 3 four four CD cord-256343-dtfw8o4g 96 4 genes gene NNS cord-256343-dtfw8o4g 96 5 , , , cord-256343-dtfw8o4g 96 6 A. a. NN cord-256343-dtfw8o4g 96 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 96 8 clusters cluster NNS cord-256343-dtfw8o4g 96 9 show show VBP cord-256343-dtfw8o4g 96 10 an an DT cord-256343-dtfw8o4g 96 11 increasing increase VBG cord-256343-dtfw8o4g 96 12 distance distance NN cord-256343-dtfw8o4g 96 13 from from IN cord-256343-dtfw8o4g 96 14 the the DT cord-256343-dtfw8o4g 96 15 G. G. NNP cord-256343-dtfw8o4g 96 16 gallus gallus NN cord-256343-dtfw8o4g 96 17 clusters cluster NNS cord-256343-dtfw8o4g 96 18 , , , cord-256343-dtfw8o4g 96 19 with with IN cord-256343-dtfw8o4g 96 20 them -PRON- PRP cord-256343-dtfw8o4g 96 21 being be VBG cord-256343-dtfw8o4g 96 22 closer close JJR cord-256343-dtfw8o4g 96 23 to to IN cord-256343-dtfw8o4g 96 24 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 97 1 ( ( -LRB- cord-256343-dtfw8o4g 97 2 from from IN cord-256343-dtfw8o4g 97 3 the the DT cord-256343-dtfw8o4g 97 4 respiratory respiratory JJ cord-256343-dtfw8o4g 97 5 tract tract NN cord-256343-dtfw8o4g 97 6 ) ) -RRB- cord-256343-dtfw8o4g 97 7 and and CC cord-256343-dtfw8o4g 97 8 more more RBR cord-256343-dtfw8o4g 97 9 distant distant JJ cord-256343-dtfw8o4g 97 10 from from IN cord-256343-dtfw8o4g 97 11 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 97 12 ( ( -LRB- cord-256343-dtfw8o4g 97 13 from from IN cord-256343-dtfw8o4g 97 14 the the DT cord-256343-dtfw8o4g 97 15 intestine intestine NN cord-256343-dtfw8o4g 97 16 ) ) -RRB- cord-256343-dtfw8o4g 97 17 and and CC cord-256343-dtfw8o4g 97 18 with with IN cord-256343-dtfw8o4g 97 19 the the DT cord-256343-dtfw8o4g 97 20 ubiquitous ubiquitous JJ cord-256343-dtfw8o4g 97 21 beta beta NN cord-256343-dtfw8o4g 97 22 - - HYPH cord-256343-dtfw8o4g 97 23 actin actin NN cord-256343-dtfw8o4g 97 24 cluster cluster NN cord-256343-dtfw8o4g 97 25 being be VBG cord-256343-dtfw8o4g 97 26 the the DT cord-256343-dtfw8o4g 97 27 most most RBS cord-256343-dtfw8o4g 97 28 distant distant JJ cord-256343-dtfw8o4g 97 29 from from IN cord-256343-dtfw8o4g 97 30 both both CC cord-256343-dtfw8o4g 97 31 A. a. NN cord-256343-dtfw8o4g 97 32 coronavirus coronavirus NN cord-256343-dtfw8o4g 97 33 and and CC cord-256343-dtfw8o4g 97 34 the the DT cord-256343-dtfw8o4g 97 35 other other JJ cord-256343-dtfw8o4g 97 36 G. G. NNP cord-256343-dtfw8o4g 97 37 gallus gallus NN cord-256343-dtfw8o4g 97 38 clusters cluster NNS cord-256343-dtfw8o4g 97 39 . . . cord-256343-dtfw8o4g 98 1 Mean mean JJ cord-256343-dtfw8o4g 98 2 CAI CAI NNP cord-256343-dtfw8o4g 98 3 values value NNS cord-256343-dtfw8o4g 98 4 for for IN cord-256343-dtfw8o4g 98 5 the the DT cord-256343-dtfw8o4g 98 6 A. a. JJ cord-256343-dtfw8o4g 98 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 98 8 S S NNP cord-256343-dtfw8o4g 98 9 , , , cord-256343-dtfw8o4g 98 10 N N NNP cord-256343-dtfw8o4g 98 11 , , , cord-256343-dtfw8o4g 98 12 NSP2 NSP2 NNP cord-256343-dtfw8o4g 98 13 and and CC cord-256343-dtfw8o4g 98 14 PL PL NNP cord-256343-dtfw8o4g 98 15 pro pro JJ cord-256343-dtfw8o4g 98 16 genes gene NNS cord-256343-dtfw8o4g 98 17 were be VBD cord-256343-dtfw8o4g 98 18 0.66 0.66 CD cord-256343-dtfw8o4g 98 19 ( ( -LRB- cord-256343-dtfw8o4g 98 20 sd sd NN cord-256343-dtfw8o4g 98 21 0.01 0.01 CD cord-256343-dtfw8o4g 98 22 ) ) -RRB- cord-256343-dtfw8o4g 98 23 , , , cord-256343-dtfw8o4g 98 24 0.77 0.77 CD cord-256343-dtfw8o4g 98 25 ( ( -LRB- cord-256343-dtfw8o4g 98 26 sd sd NNP cord-256343-dtfw8o4g 98 27 0.01 0.01 CD cord-256343-dtfw8o4g 98 28 ) ) -RRB- cord-256343-dtfw8o4g 98 29 , , , cord-256343-dtfw8o4g 98 30 0.69 0.69 CD cord-256343-dtfw8o4g 98 31 ( ( -LRB- cord-256343-dtfw8o4g 98 32 sd sd NNP cord-256343-dtfw8o4g 98 33 0.01 0.01 CD cord-256343-dtfw8o4g 98 34 ) ) -RRB- cord-256343-dtfw8o4g 98 35 and and CC cord-256343-dtfw8o4g 98 36 0.7 0.7 CD cord-256343-dtfw8o4g 98 37 ( ( -LRB- cord-256343-dtfw8o4g 98 38 sd sd NN cord-256343-dtfw8o4g 98 39 0.01 0.01 CD cord-256343-dtfw8o4g 98 40 ) ) -RRB- cord-256343-dtfw8o4g 98 41 , , , cord-256343-dtfw8o4g 98 42 respectively respectively RB cord-256343-dtfw8o4g 98 43 , , , cord-256343-dtfw8o4g 98 44 while while IN cord-256343-dtfw8o4g 98 45 , , , cord-256343-dtfw8o4g 98 46 for for IN cord-256343-dtfw8o4g 98 47 the the DT cord-256343-dtfw8o4g 98 48 G. G. NNP cord-256343-dtfw8o4g 98 49 gallus gallus NN cord-256343-dtfw8o4g 98 50 genes gene NNS cord-256343-dtfw8o4g 98 51 , , , cord-256343-dtfw8o4g 98 52 the the DT cord-256343-dtfw8o4g 98 53 mean mean JJ cord-256343-dtfw8o4g 98 54 CAI CAI NNP cord-256343-dtfw8o4g 98 55 was be VBD cord-256343-dtfw8o4g 98 56 0.81 0.81 CD cord-256343-dtfw8o4g 98 57 ( ( -LRB- cord-256343-dtfw8o4g 98 58 sd sd NNP cord-256343-dtfw8o4g 98 59 0.06 0.06 CD cord-256343-dtfw8o4g 98 60 ) ) -RRB- cord-256343-dtfw8o4g 98 61 , , , cord-256343-dtfw8o4g 98 62 ranging range VBG cord-256343-dtfw8o4g 98 63 from from IN cord-256343-dtfw8o4g 98 64 0.71 0.71 CD cord-256343-dtfw8o4g 98 65 for for IN cord-256343-dtfw8o4g 98 66 the the DT cord-256343-dtfw8o4g 98 67 pulmonary pulmonary JJ cord-256343-dtfw8o4g 98 68 gene gene NN cord-256343-dtfw8o4g 98 69 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 98 70 to to IN cord-256343-dtfw8o4g 98 71 0.88 0.88 CD cord-256343-dtfw8o4g 98 72 for for IN cord-256343-dtfw8o4g 98 73 the the DT cord-256343-dtfw8o4g 98 74 renal renal JJ cord-256343-dtfw8o4g 98 75 vitamin vitamin NN cord-256343-dtfw8o4g 98 76 D D NNP cord-256343-dtfw8o4g 98 77 receptor receptor NN cord-256343-dtfw8o4g 98 78 ( ( -LRB- cord-256343-dtfw8o4g 98 79 mean mean JJ cord-256343-dtfw8o4g 98 80 values value NNS cord-256343-dtfw8o4g 98 81 for for IN cord-256343-dtfw8o4g 98 82 two two CD cord-256343-dtfw8o4g 98 83 sequences sequence NNS cord-256343-dtfw8o4g 98 84 ) ) -RRB- cord-256343-dtfw8o4g 98 85 . . . cord-256343-dtfw8o4g 99 1 A a DT cord-256343-dtfw8o4g 99 2 boxplot boxplot NN cord-256343-dtfw8o4g 99 3 representation representation NN cord-256343-dtfw8o4g 99 4 of of IN cord-256343-dtfw8o4g 99 5 G. G. NNP cord-256343-dtfw8o4g 99 6 gallus gallus NN cord-256343-dtfw8o4g 99 7 and and CC cord-256343-dtfw8o4g 99 8 A. a. NN cord-256343-dtfw8o4g 99 9 coronavirus coronavirus NN cord-256343-dtfw8o4g 99 10 CAIs CAIs NNP cord-256343-dtfw8o4g 99 11 ( ( -LRB- cord-256343-dtfw8o4g 99 12 Fig Fig NNP cord-256343-dtfw8o4g 99 13 . . NNP cord-256343-dtfw8o4g 99 14 2 2 CD cord-256343-dtfw8o4g 99 15 ) ) -RRB- cord-256343-dtfw8o4g 99 16 shows show VBZ cord-256343-dtfw8o4g 99 17 that that IN cord-256343-dtfw8o4g 99 18 , , , cord-256343-dtfw8o4g 99 19 in in IN cord-256343-dtfw8o4g 99 20 relation relation NN cord-256343-dtfw8o4g 99 21 to to IN cord-256343-dtfw8o4g 99 22 G. G. NNP cord-256343-dtfw8o4g 99 23 gallus gallus NN cord-256343-dtfw8o4g 99 24 , , , cord-256343-dtfw8o4g 99 25 S S NNP cord-256343-dtfw8o4g 99 26 has have VBZ cord-256343-dtfw8o4g 99 27 the the DT cord-256343-dtfw8o4g 99 28 lowest low JJS cord-256343-dtfw8o4g 99 29 values value NNS cord-256343-dtfw8o4g 99 30 ( ( -LRB- cord-256343-dtfw8o4g 99 31 0.64 0.64 CD cord-256343-dtfw8o4g 99 32 - - SYM cord-256343-dtfw8o4g 99 33 0.7 0.7 CD cord-256343-dtfw8o4g 99 34 ) ) -RRB- cord-256343-dtfw8o4g 99 35 and and CC cord-256343-dtfw8o4g 99 36 N N NNP cord-256343-dtfw8o4g 99 37 has have VBZ cord-256343-dtfw8o4g 99 38 the the DT cord-256343-dtfw8o4g 99 39 highest high JJS cord-256343-dtfw8o4g 99 40 values value NNS cord-256343-dtfw8o4g 99 41 ( ( -LRB- cord-256343-dtfw8o4g 99 42 0.75 0.75 CD cord-256343-dtfw8o4g 99 43 - - SYM cord-256343-dtfw8o4g 99 44 0.79 0.79 CD cord-256343-dtfw8o4g 99 45 ) ) -RRB- cord-256343-dtfw8o4g 99 46 , , , cord-256343-dtfw8o4g 99 47 while while IN cord-256343-dtfw8o4g 99 48 NSP2 NSP2 NNP cord-256343-dtfw8o4g 99 49 and and CC cord-256343-dtfw8o4g 99 50 PL PL NNP cord-256343-dtfw8o4g 99 51 pro pro JJ cord-256343-dtfw8o4g 99 52 have have VBP cord-256343-dtfw8o4g 99 53 intermediate intermediate JJ cord-256343-dtfw8o4g 99 54 values value NNS cord-256343-dtfw8o4g 99 55 ( ( -LRB- cord-256343-dtfw8o4g 99 56 0.69 0.69 CD cord-256343-dtfw8o4g 99 57 - - SYM cord-256343-dtfw8o4g 99 58 0.71 0.71 CD cord-256343-dtfw8o4g 99 59 ) ) -RRB- cord-256343-dtfw8o4g 99 60 , , , cord-256343-dtfw8o4g 99 61 with with IN cord-256343-dtfw8o4g 99 62 non non JJ cord-256343-dtfw8o4g 99 63 - - JJ cord-256343-dtfw8o4g 99 64 overlapping overlapping JJ cord-256343-dtfw8o4g 99 65 medians median NNS cord-256343-dtfw8o4g 99 66 . . . cord-256343-dtfw8o4g 100 1 The the DT cord-256343-dtfw8o4g 100 2 mean mean JJ cord-256343-dtfw8o4g 100 3 Nc Nc NNP cord-256343-dtfw8o4g 100 4 values value NNS cord-256343-dtfw8o4g 100 5 for for IN cord-256343-dtfw8o4g 100 6 A. a. NN cord-256343-dtfw8o4g 100 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 100 8 S S NNP cord-256343-dtfw8o4g 100 9 , , , cord-256343-dtfw8o4g 100 10 N N NNP cord-256343-dtfw8o4g 100 11 , , , cord-256343-dtfw8o4g 100 12 NSP2 NSP2 NNP cord-256343-dtfw8o4g 100 13 and and CC cord-256343-dtfw8o4g 100 14 PL PL NNP cord-256343-dtfw8o4g 100 15 pro pro NNP cord-256343-dtfw8o4g 100 16 were be VBD cord-256343-dtfw8o4g 100 17 43 43 CD cord-256343-dtfw8o4g 100 18 ( ( -LRB- cord-256343-dtfw8o4g 100 19 sd sd NN cord-256343-dtfw8o4g 100 20 2.31 2.31 CD cord-256343-dtfw8o4g 100 21 ) ) -RRB- cord-256343-dtfw8o4g 100 22 , , , cord-256343-dtfw8o4g 100 23 44.9 44.9 CD cord-256343-dtfw8o4g 100 24 ( ( -LRB- cord-256343-dtfw8o4g 100 25 sd sd NNP cord-256343-dtfw8o4g 100 26 3.64 3.64 CD cord-256343-dtfw8o4g 100 27 ) ) -RRB- cord-256343-dtfw8o4g 100 28 , , , cord-256343-dtfw8o4g 100 29 51.33 51.33 CD cord-256343-dtfw8o4g 100 30 ( ( -LRB- cord-256343-dtfw8o4g 100 31 sd sd NNP cord-256343-dtfw8o4g 100 32 1.56 1.56 CD cord-256343-dtfw8o4g 100 33 ) ) -RRB- cord-256343-dtfw8o4g 100 34 and and CC cord-256343-dtfw8o4g 100 35 43.79 43.79 CD cord-256343-dtfw8o4g 100 36 ( ( -LRB- cord-256343-dtfw8o4g 100 37 sd sd NN cord-256343-dtfw8o4g 100 38 0.86 0.86 CD cord-256343-dtfw8o4g 100 39 ) ) -RRB- cord-256343-dtfw8o4g 100 40 , , , cord-256343-dtfw8o4g 100 41 respectively respectively RB cord-256343-dtfw8o4g 100 42 , , , cord-256343-dtfw8o4g 100 43 and and CC cord-256343-dtfw8o4g 100 44 for for IN cord-256343-dtfw8o4g 100 45 G. G. NNP cord-256343-dtfw8o4g 100 46 gallus gallus NN cord-256343-dtfw8o4g 100 47 , , , cord-256343-dtfw8o4g 100 48 the the DT cord-256343-dtfw8o4g 100 49 mean mean JJ cord-256343-dtfw8o4g 100 50 Nc Nc NNP cord-256343-dtfw8o4g 100 51 values value NNS cord-256343-dtfw8o4g 100 52 were be VBD cord-256343-dtfw8o4g 100 53 33.59 33.59 CD cord-256343-dtfw8o4g 100 54 for for IN cord-256343-dtfw8o4g 100 55 vitamin vitamin NN cord-256343-dtfw8o4g 100 56 D D NNP cord-256343-dtfw8o4g 100 57 receptor receptor NN cord-256343-dtfw8o4g 100 58 , , , cord-256343-dtfw8o4g 100 59 40.03 40.03 CD cord-256343-dtfw8o4g 100 60 for for IN cord-256343-dtfw8o4g 100 61 beta beta NN cord-256343-dtfw8o4g 100 62 - - HYPH cord-256343-dtfw8o4g 100 63 actin actin JJ cord-256343-dtfw8o4g 100 64 , , , cord-256343-dtfw8o4g 100 65 46.48 46.48 CD cord-256343-dtfw8o4g 100 66 for for IN cord-256343-dtfw8o4g 100 67 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 100 68 , , , cord-256343-dtfw8o4g 100 69 50.21 50.21 CD cord-256343-dtfw8o4g 100 70 for for IN cord-256343-dtfw8o4g 100 71 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 100 72 and and CC cord-256343-dtfw8o4g 100 73 53.01 53.01 CD cord-256343-dtfw8o4g 100 74 for for IN cord-256343-dtfw8o4g 100 75 ovomucin ovomucin NNS cord-256343-dtfw8o4g 100 76 . . . cord-256343-dtfw8o4g 101 1 The the DT cord-256343-dtfw8o4g 101 2 Nc Nc NNP cord-256343-dtfw8o4g 101 3 x x NN cord-256343-dtfw8o4g 101 4 GC GC NNP cord-256343-dtfw8o4g 101 5 3 3 CD cord-256343-dtfw8o4g 101 6 % % NN cord-256343-dtfw8o4g 101 7 graphs graph NNS cord-256343-dtfw8o4g 101 8 ( ( -LRB- cord-256343-dtfw8o4g 101 9 Fig fig NN cord-256343-dtfw8o4g 101 10 . . . cord-256343-dtfw8o4g 101 11 3 3 LS cord-256343-dtfw8o4g 101 12 ) ) -RRB- cord-256343-dtfw8o4g 101 13 show show VBP cord-256343-dtfw8o4g 101 14 that that IN cord-256343-dtfw8o4g 101 15 , , , cord-256343-dtfw8o4g 101 16 regardless regardless RB cord-256343-dtfw8o4g 101 17 of of IN cord-256343-dtfw8o4g 101 18 the the DT cord-256343-dtfw8o4g 101 19 A. a. JJ cord-256343-dtfw8o4g 101 20 coronavirus coronavirus NN cord-256343-dtfw8o4g 101 21 gene gene NN cord-256343-dtfw8o4g 101 22 under under IN cord-256343-dtfw8o4g 101 23 consideration consideration NN cord-256343-dtfw8o4g 101 24 ( ( -LRB- cord-256343-dtfw8o4g 101 25 S S NNP cord-256343-dtfw8o4g 101 26 , , , cord-256343-dtfw8o4g 101 27 N N NNP cord-256343-dtfw8o4g 101 28 , , , cord-256343-dtfw8o4g 101 29 NSP2 NSP2 NNP cord-256343-dtfw8o4g 101 30 or or CC cord-256343-dtfw8o4g 101 31 PL PL NNP cord-256343-dtfw8o4g 101 32 pro pro FW cord-256343-dtfw8o4g 101 33 ) ) -RRB- cord-256343-dtfw8o4g 101 34 , , , cord-256343-dtfw8o4g 101 35 all all DT cord-256343-dtfw8o4g 101 36 plots plot NNS cord-256343-dtfw8o4g 101 37 fall fall VBP cord-256343-dtfw8o4g 101 38 either either CC cord-256343-dtfw8o4g 101 39 just just RB cord-256343-dtfw8o4g 101 40 below below RB cord-256343-dtfw8o4g 101 41 or or CC cord-256343-dtfw8o4g 101 42 in in IN cord-256343-dtfw8o4g 101 43 the the DT cord-256343-dtfw8o4g 101 44 vicinity vicinity NN cord-256343-dtfw8o4g 101 45 of of IN cord-256343-dtfw8o4g 101 46 the the DT cord-256343-dtfw8o4g 101 47 ENC ENC NNP cord-256343-dtfw8o4g 101 48 × × NNP cord-256343-dtfw8o4g 101 49 GC GC NNP cord-256343-dtfw8o4g 101 50 3 3 CD cord-256343-dtfw8o4g 101 51 % % NN cord-256343-dtfw8o4g 101 52 expected expect VBN cord-256343-dtfw8o4g 101 53 curve curve NN cord-256343-dtfw8o4g 101 54 . . . cord-256343-dtfw8o4g 102 1 This this DT cord-256343-dtfw8o4g 102 2 same same JJ cord-256343-dtfw8o4g 102 3 pattern pattern NN cord-256343-dtfw8o4g 102 4 was be VBD cord-256343-dtfw8o4g 102 5 also also RB cord-256343-dtfw8o4g 102 6 found find VBN cord-256343-dtfw8o4g 102 7 for for IN cord-256343-dtfw8o4g 102 8 the the DT cord-256343-dtfw8o4g 102 9 G. G. NNP cord-256343-dtfw8o4g 102 10 gallus gallus NN cord-256343-dtfw8o4g 102 11 genes gene NNS cord-256343-dtfw8o4g 102 12 , , , cord-256343-dtfw8o4g 102 13 though though IN cord-256343-dtfw8o4g 102 14 with with IN cord-256343-dtfw8o4g 102 15 plots plot NNS cord-256343-dtfw8o4g 102 16 dislocated dislocate VBN cord-256343-dtfw8o4g 102 17 to to IN cord-256343-dtfw8o4g 102 18 the the DT cord-256343-dtfw8o4g 102 19 right right JJ cord-256343-dtfw8o4g 102 20 side side NN cord-256343-dtfw8o4g 102 21 of of IN cord-256343-dtfw8o4g 102 22 the the DT cord-256343-dtfw8o4g 102 23 graph graph NN cord-256343-dtfw8o4g 102 24 due due IN cord-256343-dtfw8o4g 102 25 to to IN cord-256343-dtfw8o4g 102 26 a a DT cord-256343-dtfw8o4g 102 27 higher high JJR cord-256343-dtfw8o4g 102 28 GC GC NNP cord-256343-dtfw8o4g 102 29 3 3 CD cord-256343-dtfw8o4g 102 30 % % NN cord-256343-dtfw8o4g 102 31 content content NN cord-256343-dtfw8o4g 102 32 . . . cord-256343-dtfw8o4g 103 1 The the DT cord-256343-dtfw8o4g 103 2 number number NN cord-256343-dtfw8o4g 103 3 of of IN cord-256343-dtfw8o4g 103 4 100 100 CD cord-256343-dtfw8o4g 103 5 % % NN cord-256343-dtfw8o4g 103 6 conserved conserve VBN cord-256343-dtfw8o4g 103 7 amino amino NN cord-256343-dtfw8o4g 103 8 acid acid NN cord-256343-dtfw8o4g 103 9 positions position NNS cord-256343-dtfw8o4g 103 10 coded code VBN cord-256343-dtfw8o4g 103 11 by by IN cord-256343-dtfw8o4g 103 12 the the DT cord-256343-dtfw8o4g 103 13 preferred preferred JJ cord-256343-dtfw8o4g 103 14 codons codon NNS cord-256343-dtfw8o4g 103 15 for for IN cord-256343-dtfw8o4g 103 16 genes gene NNS cord-256343-dtfw8o4g 103 17 S S NNP cord-256343-dtfw8o4g 103 18 , , , cord-256343-dtfw8o4g 103 19 N N NNP cord-256343-dtfw8o4g 103 20 , , , cord-256343-dtfw8o4g 103 21 NSP2 NSP2 NNP cord-256343-dtfw8o4g 103 22 and and CC cord-256343-dtfw8o4g 103 23 PL PL NNP cord-256343-dtfw8o4g 103 24 pro pro NNP cord-256343-dtfw8o4g 103 25 was be VBD cord-256343-dtfw8o4g 103 26 one one CD cord-256343-dtfw8o4g 103 27 , , , cord-256343-dtfw8o4g 103 28 20 20 CD cord-256343-dtfw8o4g 103 29 , , , cord-256343-dtfw8o4g 103 30 28 28 CD cord-256343-dtfw8o4g 103 31 and and CC cord-256343-dtfw8o4g 103 32 71 71 CD cord-256343-dtfw8o4g 103 33 , , , cord-256343-dtfw8o4g 103 34 respectively respectively RB cord-256343-dtfw8o4g 103 35 . . . cord-256343-dtfw8o4g 104 1 Fisher Fisher NNP cord-256343-dtfw8o4g 104 2 's 's POS cord-256343-dtfw8o4g 104 3 exact exact JJ cord-256343-dtfw8o4g 104 4 test test NN cord-256343-dtfw8o4g 104 5 showed show VBD cord-256343-dtfw8o4g 104 6 that that IN cord-256343-dtfw8o4g 104 7 only only RB cord-256343-dtfw8o4g 104 8 the the DT cord-256343-dtfw8o4g 104 9 S S NNP cord-256343-dtfw8o4g 104 10 gene gene NN cord-256343-dtfw8o4g 104 11 presented present VBD cord-256343-dtfw8o4g 104 12 a a DT cord-256343-dtfw8o4g 104 13 statistically statistically RB cord-256343-dtfw8o4g 104 14 significant significant JJ cord-256343-dtfw8o4g 104 15 lower low JJR cord-256343-dtfw8o4g 104 16 number number NN cord-256343-dtfw8o4g 104 17 of of IN cord-256343-dtfw8o4g 104 18 occurrences occurrence NNS cord-256343-dtfw8o4g 104 19 ( ( -LRB- cord-256343-dtfw8o4g 104 20 Table table NN cord-256343-dtfw8o4g 104 21 1 1 CD cord-256343-dtfw8o4g 104 22 ) ) -RRB- cord-256343-dtfw8o4g 104 23 when when WRB cord-256343-dtfw8o4g 104 24 compared compare VBN cord-256343-dtfw8o4g 104 25 to to IN cord-256343-dtfw8o4g 104 26 the the DT cord-256343-dtfw8o4g 104 27 other other JJ cord-256343-dtfw8o4g 104 28 3 3 CD cord-256343-dtfw8o4g 104 29 genes gene NNS cord-256343-dtfw8o4g 104 30 ( ( -LRB- cord-256343-dtfw8o4g 104 31 p p NN cord-256343-dtfw8o4g 104 32 < < XX cord-256343-dtfw8o4g 104 33 0.0001 0.0001 CD cord-256343-dtfw8o4g 104 34 ) ) -RRB- cord-256343-dtfw8o4g 104 35 , , , cord-256343-dtfw8o4g 104 36 with with IN cord-256343-dtfw8o4g 104 37 ORs ORs NNPS cord-256343-dtfw8o4g 104 38 _SP cord-256343-dtfw8o4g 104 39 Conserved conserved JJ cord-256343-dtfw8o4g 104 40 amino amino NN cord-256343-dtfw8o4g 104 41 acid acid NN cord-256343-dtfw8o4g 104 42 ( ( -LRB- cord-256343-dtfw8o4g 104 43 aa aa NNP cord-256343-dtfw8o4g 104 44 ) ) -RRB- cord-256343-dtfw8o4g 104 45 positions position NNS cord-256343-dtfw8o4g 104 46 in in IN cord-256343-dtfw8o4g 104 47 the the DT cord-256343-dtfw8o4g 104 48 Avian avian JJ cord-256343-dtfw8o4g 104 49 coronavirus coronavirus NN cord-256343-dtfw8o4g 104 50 spike spike NN cord-256343-dtfw8o4g 104 51 ( ( -LRB- cord-256343-dtfw8o4g 104 52 S S NNP cord-256343-dtfw8o4g 104 53 ) ) -RRB- cord-256343-dtfw8o4g 104 54 , , , cord-256343-dtfw8o4g 104 55 nucleocapsid nucleocapsid NN cord-256343-dtfw8o4g 104 56 ( ( -LRB- cord-256343-dtfw8o4g 104 57 N N NNP cord-256343-dtfw8o4g 104 58 ) ) -RRB- cord-256343-dtfw8o4g 104 59 , , , cord-256343-dtfw8o4g 104 60 non non JJ cord-256343-dtfw8o4g 104 61 - - JJ cord-256343-dtfw8o4g 104 62 structural structural JJ cord-256343-dtfw8o4g 104 63 protein protein NN cord-256343-dtfw8o4g 104 64 2 2 CD cord-256343-dtfw8o4g 104 65 ( ( -LRB- cord-256343-dtfw8o4g 104 66 NSP2 NSP2 NNP cord-256343-dtfw8o4g 104 67 ) ) -RRB- cord-256343-dtfw8o4g 104 68 and and CC cord-256343-dtfw8o4g 104 69 papain papain NN cord-256343-dtfw8o4g 104 70 - - HYPH cord-256343-dtfw8o4g 104 71 like like JJ cord-256343-dtfw8o4g 104 72 protease protease NN cord-256343-dtfw8o4g 104 73 ( ( -LRB- cord-256343-dtfw8o4g 104 74 PL pl NN cord-256343-dtfw8o4g 104 75 pro pro NN cord-256343-dtfw8o4g 104 76 ) ) -RRB- cord-256343-dtfw8o4g 104 77 genes gene NNS cord-256343-dtfw8o4g 104 78 coded code VBN cord-256343-dtfw8o4g 104 79 by by IN cord-256343-dtfw8o4g 104 80 a a DT cord-256343-dtfw8o4g 104 81 preferred preferred JJ cord-256343-dtfw8o4g 104 82 codon codon NN cord-256343-dtfw8o4g 104 83 and and CC cord-256343-dtfw8o4g 104 84 the the DT cord-256343-dtfw8o4g 104 85 preferred preferred JJ cord-256343-dtfw8o4g 104 86 codon codon NN cord-256343-dtfw8o4g 104 87 for for IN cord-256343-dtfw8o4g 104 88 each each DT cord-256343-dtfw8o4g 104 89 aa aa NNP cord-256343-dtfw8o4g 104 90 in in IN cord-256343-dtfw8o4g 104 91 the the DT cord-256343-dtfw8o4g 104 92 Gallus Gallus NNP cord-256343-dtfw8o4g 104 93 gallus gallus NN cord-256343-dtfw8o4g 104 94 beta beta NN cord-256343-dtfw8o4g 104 95 - - HYPH cord-256343-dtfw8o4g 104 96 actin actin JJ cord-256343-dtfw8o4g 104 97 ( ( -LRB- cord-256343-dtfw8o4g 104 98 B b NN cord-256343-dtfw8o4g 104 99 - - HYPH cord-256343-dtfw8o4g 104 100 act act NNP cord-256343-dtfw8o4g 104 101 ) ) -RRB- cord-256343-dtfw8o4g 104 102 , , , cord-256343-dtfw8o4g 104 103 lung lung NN cord-256343-dtfw8o4g 104 104 surfactant surfactant NN cord-256343-dtfw8o4g 104 105 protein protein NN cord-256343-dtfw8o4g 104 106 A A NNP cord-256343-dtfw8o4g 104 107 ( ( -LRB- cord-256343-dtfw8o4g 104 108 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 104 109 ) ) -RRB- cord-256343-dtfw8o4g 104 110 , , , cord-256343-dtfw8o4g 104 111 intestinal intestinal JJ cord-256343-dtfw8o4g 104 112 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 104 113 ( ( -LRB- cord-256343-dtfw8o4g 104 114 CCK CCK NNP cord-256343-dtfw8o4g 104 115 ) ) -RRB- cord-256343-dtfw8o4g 104 116 , , , cord-256343-dtfw8o4g 104 117 oviduct oviduct NN cord-256343-dtfw8o4g 104 118 ovomucin ovomucin NNP cord-256343-dtfw8o4g 104 119 alpha alpha NN cord-256343-dtfw8o4g 104 120 subunit subunit NNP cord-256343-dtfw8o4g 104 121 ( ( -LRB- cord-256343-dtfw8o4g 104 122 Ovo Ovo NNP cord-256343-dtfw8o4g 104 123 ) ) -RRB- cord-256343-dtfw8o4g 104 124 and and CC cord-256343-dtfw8o4g 104 125 kidney kidney NN cord-256343-dtfw8o4g 104 126 vitamin vitamin NN cord-256343-dtfw8o4g 104 127 D D NNP cord-256343-dtfw8o4g 104 128 receptor receptor NN cord-256343-dtfw8o4g 104 129 ( ( -LRB- cord-256343-dtfw8o4g 104 130 ViTD ViTD NNP cord-256343-dtfw8o4g 104 131 rec rec NNP cord-256343-dtfw8o4g 104 132 ) ) -RRB- cord-256343-dtfw8o4g 104 133 genes gene NNS cord-256343-dtfw8o4g 104 134 . . . cord-256343-dtfw8o4g 105 1 Tryptophan tryptophan NN cord-256343-dtfw8o4g 105 2 and and CC cord-256343-dtfw8o4g 105 3 methionine methionine NN cord-256343-dtfw8o4g 105 4 , , , cord-256343-dtfw8o4g 105 5 coded code VBN cord-256343-dtfw8o4g 105 6 by by IN cord-256343-dtfw8o4g 105 7 a a DT cord-256343-dtfw8o4g 105 8 single single JJ cord-256343-dtfw8o4g 105 9 codon codon NN cord-256343-dtfw8o4g 105 10 , , , cord-256343-dtfw8o4g 105 11 were be VBD cord-256343-dtfw8o4g 105 12 excluded exclude VBN cord-256343-dtfw8o4g 105 13 . . . cord-256343-dtfw8o4g 106 1 Codon codon NN cord-256343-dtfw8o4g 106 2 preference preference NN cord-256343-dtfw8o4g 106 3 was be VBD cord-256343-dtfw8o4g 106 4 indicated indicate VBN cord-256343-dtfw8o4g 106 5 by by IN cord-256343-dtfw8o4g 106 6 relative relative JJ cord-256343-dtfw8o4g 106 7 synonymous synonymous JJ cord-256343-dtfw8o4g 106 8 codon codon NN cord-256343-dtfw8o4g 106 9 usage usage NN cord-256343-dtfw8o4g 106 10 ( ( -LRB- cord-256343-dtfw8o4g 106 11 RSCU RSCU NNP cord-256343-dtfw8o4g 106 12 ) ) -RRB- cord-256343-dtfw8o4g 107 1 > > XX cord-256343-dtfw8o4g 108 1 1 1 LS cord-256343-dtfw8o4g 108 2 . . . cord-256343-dtfw8o4g 109 1 Positions position NNS cord-256343-dtfw8o4g 109 2 are be VBP cord-256343-dtfw8o4g 109 3 provided provide VBN cord-256343-dtfw8o4g 109 4 only only RB cord-256343-dtfw8o4g 109 5 for for IN cord-256343-dtfw8o4g 109 6 Avian avian JJ cord-256343-dtfw8o4g 109 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 109 8 genes gene NNS cord-256343-dtfw8o4g 109 9 as as IN cord-256343-dtfw8o4g 109 10 G. G. NNP cord-256343-dtfw8o4g 109 11 gallus gallus NN cord-256343-dtfw8o4g 109 12 genes gene NNS cord-256343-dtfw8o4g 109 13 were be VBD cord-256343-dtfw8o4g 109 14 used use VBN cord-256343-dtfw8o4g 109 15 as as IN cord-256343-dtfw8o4g 109 16 the the DT cord-256343-dtfw8o4g 109 17 reference reference NN cord-256343-dtfw8o4g 109 18 for for IN cord-256343-dtfw8o4g 109 19 comparison comparison NN cord-256343-dtfw8o4g 109 20 . . . cord-256343-dtfw8o4g 110 1 NC NC NNP cord-256343-dtfw8o4g 110 2 : : : cord-256343-dtfw8o4g 110 3 no no DT cord-256343-dtfw8o4g 110 4 100 100 CD cord-256343-dtfw8o4g 110 5 % % NN cord-256343-dtfw8o4g 110 6 conserved conserve VBN cord-256343-dtfw8o4g 110 7 amino amino NN cord-256343-dtfw8o4g 110 8 acids acid NNS cord-256343-dtfw8o4g 110 9 positions position NNS cord-256343-dtfw8o4g 110 10 coded code VBN cord-256343-dtfw8o4g 110 11 by by IN cord-256343-dtfw8o4g 110 12 the the DT cord-256343-dtfw8o4g 110 13 preferred preferred JJ cord-256343-dtfw8o4g 110 14 codon codon NN cord-256343-dtfw8o4g 110 15 ; ; : cord-256343-dtfw8o4g 110 16 NF nf NN cord-256343-dtfw8o4g 110 17 : : : cord-256343-dtfw8o4g 110 18 amino amino NN cord-256343-dtfw8o4g 110 19 acid acid NN cord-256343-dtfw8o4g 110 20 not not RB cord-256343-dtfw8o4g 110 21 found find VBN cord-256343-dtfw8o4g 110 22 in in IN cord-256343-dtfw8o4g 110 23 the the DT cord-256343-dtfw8o4g 110 24 sequence sequence NN cord-256343-dtfw8o4g 110 25 . . . cord-256343-dtfw8o4g 111 1 The the DT cord-256343-dtfw8o4g 111 2 mean mean JJ cord-256343-dtfw8o4g 111 3 number number NN cord-256343-dtfw8o4g 111 4 of of IN cord-256343-dtfw8o4g 111 5 amino amino NN cord-256343-dtfw8o4g 111 6 acid acid NN cord-256343-dtfw8o4g 111 7 residues residue NNS cord-256343-dtfw8o4g 111 8 in in IN cord-256343-dtfw8o4g 111 9 the the DT cord-256343-dtfw8o4g 111 10 sequences sequence NNS cord-256343-dtfw8o4g 111 11 used use VBN cord-256343-dtfw8o4g 111 12 for for IN cord-256343-dtfw8o4g 111 13 this this DT cord-256343-dtfw8o4g 111 14 study study NN cord-256343-dtfw8o4g 111 15 from from IN cord-256343-dtfw8o4g 111 16 the the DT cord-256343-dtfw8o4g 111 17 Avian avian JJ cord-256343-dtfw8o4g 111 18 coronavirus coronavirus NN cord-256343-dtfw8o4g 111 19 spike spike NN cord-256343-dtfw8o4g 111 20 ( ( -LRB- cord-256343-dtfw8o4g 111 21 S S NNP cord-256343-dtfw8o4g 111 22 ) ) -RRB- cord-256343-dtfw8o4g 111 23 , , , cord-256343-dtfw8o4g 111 24 nucleocapsid nucleocapsid NN cord-256343-dtfw8o4g 111 25 ( ( -LRB- cord-256343-dtfw8o4g 111 26 N N NNP cord-256343-dtfw8o4g 111 27 ) ) -RRB- cord-256343-dtfw8o4g 111 28 , , , cord-256343-dtfw8o4g 111 29 non non JJ cord-256343-dtfw8o4g 111 30 - - JJ cord-256343-dtfw8o4g 111 31 structural structural JJ cord-256343-dtfw8o4g 111 32 protein protein NN cord-256343-dtfw8o4g 111 33 2 2 CD cord-256343-dtfw8o4g 111 34 ( ( -LRB- cord-256343-dtfw8o4g 111 35 NSP2 NSP2 NNP cord-256343-dtfw8o4g 111 36 ) ) -RRB- cord-256343-dtfw8o4g 111 37 and and CC cord-256343-dtfw8o4g 111 38 papain papain NN cord-256343-dtfw8o4g 111 39 - - HYPH cord-256343-dtfw8o4g 111 40 like like JJ cord-256343-dtfw8o4g 111 41 protease protease NN cord-256343-dtfw8o4g 111 42 ( ( -LRB- cord-256343-dtfw8o4g 111 43 PL pl NN cord-256343-dtfw8o4g 111 44 pro pro NN cord-256343-dtfw8o4g 111 45 ) ) -RRB- cord-256343-dtfw8o4g 111 46 genes gene NNS cord-256343-dtfw8o4g 111 47 coded code VBN cord-256343-dtfw8o4g 111 48 by by IN cord-256343-dtfw8o4g 111 49 a a DT cord-256343-dtfw8o4g 111 50 preferred preferred JJ cord-256343-dtfw8o4g 111 51 codon codon NN cord-256343-dtfw8o4g 111 52 and and CC cord-256343-dtfw8o4g 111 53 the the DT cord-256343-dtfw8o4g 111 54 preferred preferred JJ cord-256343-dtfw8o4g 111 55 codon codon NN cord-256343-dtfw8o4g 111 56 for for IN cord-256343-dtfw8o4g 111 57 each each DT cord-256343-dtfw8o4g 111 58 aa aa NNP cord-256343-dtfw8o4g 111 59 in in IN cord-256343-dtfw8o4g 111 60 the the DT cord-256343-dtfw8o4g 111 61 Gallus Gallus NNP cord-256343-dtfw8o4g 111 62 gallus gallus NN cord-256343-dtfw8o4g 111 63 beta beta NN cord-256343-dtfw8o4g 111 64 - - HYPH cord-256343-dtfw8o4g 111 65 actin actin JJ cord-256343-dtfw8o4g 111 66 ( ( -LRB- cord-256343-dtfw8o4g 111 67 B b NN cord-256343-dtfw8o4g 111 68 - - HYPH cord-256343-dtfw8o4g 111 69 act act NNP cord-256343-dtfw8o4g 111 70 ) ) -RRB- cord-256343-dtfw8o4g 111 71 , , , cord-256343-dtfw8o4g 111 72 lung lung NN cord-256343-dtfw8o4g 111 73 surfactant surfactant NN cord-256343-dtfw8o4g 111 74 protein protein NN cord-256343-dtfw8o4g 111 75 A A NNP cord-256343-dtfw8o4g 111 76 ( ( -LRB- cord-256343-dtfw8o4g 111 77 SFTPA1 SFTPA1 NNP cord-256343-dtfw8o4g 111 78 ) ) -RRB- cord-256343-dtfw8o4g 111 79 , , , cord-256343-dtfw8o4g 111 80 intestinal intestinal JJ cord-256343-dtfw8o4g 111 81 cholecystokinin cholecystokinin NN cord-256343-dtfw8o4g 111 82 ( ( -LRB- cord-256343-dtfw8o4g 111 83 CCK CCK NNP cord-256343-dtfw8o4g 111 84 ) ) -RRB- cord-256343-dtfw8o4g 111 85 , , , cord-256343-dtfw8o4g 111 86 oviduct oviduct NN cord-256343-dtfw8o4g 111 87 ovomucin ovomucin NNP cord-256343-dtfw8o4g 111 88 alpha alpha NN cord-256343-dtfw8o4g 111 89 subunit subunit NNP cord-256343-dtfw8o4g 111 90 ( ( -LRB- cord-256343-dtfw8o4g 111 91 Ovo Ovo NNP cord-256343-dtfw8o4g 111 92 ) ) -RRB- cord-256343-dtfw8o4g 111 93 and and CC cord-256343-dtfw8o4g 111 94 kidney kidney NN cord-256343-dtfw8o4g 111 95 vitamin vitamin NN cord-256343-dtfw8o4g 111 96 D D NNP cord-256343-dtfw8o4g 111 97 receptor receptor NN cord-256343-dtfw8o4g 111 98 ( ( -LRB- cord-256343-dtfw8o4g 111 99 ViTD ViTD NNP cord-256343-dtfw8o4g 111 100 rec rec NNP cord-256343-dtfw8o4g 111 101 ) ) -RRB- cord-256343-dtfw8o4g 111 102 genes gene NNS cord-256343-dtfw8o4g 111 103 . . . cord-256343-dtfw8o4g 112 1 Table table NN cord-256343-dtfw8o4g 112 2 2 2 CD cord-256343-dtfw8o4g 112 3 . . . cord-256343-dtfw8o4g 113 1 The the DT cord-256343-dtfw8o4g 113 2 number number NN cord-256343-dtfw8o4g 113 3 of of IN cord-256343-dtfw8o4g 113 4 amino amino JJ cord-256343-dtfw8o4g 113 5 acids acid NNS cord-256343-dtfw8o4g 113 6 in in IN cord-256343-dtfw8o4g 113 7 the the DT cord-256343-dtfw8o4g 113 8 G. G. NNP cord-256343-dtfw8o4g 113 9 gallus gallus NN cord-256343-dtfw8o4g 113 10 proteins protein NNS cord-256343-dtfw8o4g 113 11 that that WDT cord-256343-dtfw8o4g 113 12 presented present VBD cord-256343-dtfw8o4g 113 13 the the DT cord-256343-dtfw8o4g 113 14 same same JJ cord-256343-dtfw8o4g 113 15 codons codon NNS cord-256343-dtfw8o4g 113 16 used use VBN cord-256343-dtfw8o4g 113 17 by by IN cord-256343-dtfw8o4g 113 18 at at RB cord-256343-dtfw8o4g 113 19 least least RBS cord-256343-dtfw8o4g 113 20 one one CD cord-256343-dtfw8o4g 113 21 of of IN cord-256343-dtfw8o4g 113 22 the the DT cord-256343-dtfw8o4g 113 23 A. a. NN cord-256343-dtfw8o4g 113 24 coronavirus coronavirus NN cord-256343-dtfw8o4g 113 25 genes gene NNS cord-256343-dtfw8o4g 113 26 in in IN cord-256343-dtfw8o4g 113 27 100 100 CD cord-256343-dtfw8o4g 113 28 % % NN cord-256343-dtfw8o4g 113 29 conserved conserved JJ cord-256343-dtfw8o4g 113 30 aa aa NNP cord-256343-dtfw8o4g 113 31 positions position NNS cord-256343-dtfw8o4g 113 32 ranged range VBD cord-256343-dtfw8o4g 113 33 from from IN cord-256343-dtfw8o4g 113 34 1 1 CD cord-256343-dtfw8o4g 113 35 ( ( -LRB- cord-256343-dtfw8o4g 113 36 for for IN cord-256343-dtfw8o4g 113 37 vitamin vitamin NN cord-256343-dtfw8o4g 113 38 D D NNP cord-256343-dtfw8o4g 113 39 receptor receptor NN cord-256343-dtfw8o4g 113 40 ) ) -RRB- cord-256343-dtfw8o4g 113 41 to to IN cord-256343-dtfw8o4g 113 42 15 15 CD cord-256343-dtfw8o4g 113 43 ( ( -LRB- cord-256343-dtfw8o4g 113 44 for for IN cord-256343-dtfw8o4g 113 45 ovomucin ovomucin NNS cord-256343-dtfw8o4g 113 46 alpha alpha NNP cord-256343-dtfw8o4g 113 47 ) ) -RRB- cord-256343-dtfw8o4g 113 48 , , , cord-256343-dtfw8o4g 113 49 and and CC cord-256343-dtfw8o4g 113 50 the the DT cord-256343-dtfw8o4g 113 51 most most RBS cord-256343-dtfw8o4g 113 52 conserved conserved JJ cord-256343-dtfw8o4g 113 53 preferred preferred JJ cord-256343-dtfw8o4g 113 54 codon codon NN cord-256343-dtfw8o4g 113 55 , , , cord-256343-dtfw8o4g 113 56 found find VBD cord-256343-dtfw8o4g 113 57 for for IN cord-256343-dtfw8o4g 113 58 all all DT cord-256343-dtfw8o4g 113 59 A. a. NN cord-256343-dtfw8o4g 113 60 coronavirus coronavirus NN cord-256343-dtfw8o4g 113 61 genes gene NNS cord-256343-dtfw8o4g 113 62 , , , cord-256343-dtfw8o4g 113 63 was be VBD cord-256343-dtfw8o4g 113 64 UUU UUU NNP cord-256343-dtfw8o4g 113 65 for for IN cord-256343-dtfw8o4g 113 66 F F NNP cord-256343-dtfw8o4g 113 67 ( ( -LRB- cord-256343-dtfw8o4g 113 68 Table Table NNP cord-256343-dtfw8o4g 113 69 1 1 CD cord-256343-dtfw8o4g 113 70 ) ) -RRB- cord-256343-dtfw8o4g 113 71 . . . cord-256343-dtfw8o4g 114 1 The the DT cord-256343-dtfw8o4g 114 2 positions position NNS cord-256343-dtfw8o4g 114 3 of of IN cord-256343-dtfw8o4g 114 4 each each DT cord-256343-dtfw8o4g 114 5 of of IN cord-256343-dtfw8o4g 114 6 the the DT cord-256343-dtfw8o4g 114 7 conserved conserve VBN cord-256343-dtfw8o4g 114 8 amino amino NN cord-256343-dtfw8o4g 114 9 acids acid NNS cord-256343-dtfw8o4g 114 10 coded code VBN cord-256343-dtfw8o4g 114 11 by by IN cord-256343-dtfw8o4g 114 12 preferred preferred JJ cord-256343-dtfw8o4g 114 13 codons codon NNS cord-256343-dtfw8o4g 114 14 for for IN cord-256343-dtfw8o4g 114 15 A. a. NN cord-256343-dtfw8o4g 114 16 coronavirus coronavirus NN cord-256343-dtfw8o4g 114 17 are be VBP cord-256343-dtfw8o4g 114 18 also also RB cord-256343-dtfw8o4g 114 19 shown show VBN cord-256343-dtfw8o4g 114 20 in in IN cord-256343-dtfw8o4g 114 21 Table Table NNP cord-256343-dtfw8o4g 114 22 1 1 CD cord-256343-dtfw8o4g 114 23 . . . cord-256343-dtfw8o4g 115 1 The the DT cord-256343-dtfw8o4g 115 2 sequences sequence NNS cord-256343-dtfw8o4g 115 3 of of IN cord-256343-dtfw8o4g 115 4 N n CD cord-256343-dtfw8o4g 115 5 , , , cord-256343-dtfw8o4g 115 6 NSP2 NSP2 NNP cord-256343-dtfw8o4g 115 7 and and CC cord-256343-dtfw8o4g 115 8 PL PL NNP cord-256343-dtfw8o4g 115 9 pro pro JJ cord-256343-dtfw8o4g 115 10 from from IN cord-256343-dtfw8o4g 115 11 all all PDT cord-256343-dtfw8o4g 115 12 the the DT cord-256343-dtfw8o4g 115 13 strains strain NNS cord-256343-dtfw8o4g 115 14 in in IN cord-256343-dtfw8o4g 115 15 this this DT cord-256343-dtfw8o4g 115 16 study study NN cord-256343-dtfw8o4g 115 17 were be VBD cord-256343-dtfw8o4g 115 18 found find VBN cord-256343-dtfw8o4g 115 19 to to TO cord-256343-dtfw8o4g 115 20 be be VB cord-256343-dtfw8o4g 115 21 under under IN cord-256343-dtfw8o4g 115 22 purifying purify VBG cord-256343-dtfw8o4g 115 23 selection selection NN cord-256343-dtfw8o4g 115 24 as as IN cord-256343-dtfw8o4g 115 25 the the DT cord-256343-dtfw8o4g 115 26 p p NN cord-256343-dtfw8o4g 115 27 values value NNS cord-256343-dtfw8o4g 115 28 from from IN cord-256343-dtfw8o4g 115 29 Fisher Fisher NNP cord-256343-dtfw8o4g 115 30 's 's POS cord-256343-dtfw8o4g 115 31 exact exact JJ cord-256343-dtfw8o4g 115 32 test test NN cord-256343-dtfw8o4g 115 33 were be VBD cord-256343-dtfw8o4g 115 34 all all RB cord-256343-dtfw8o4g 115 35 above above IN cord-256343-dtfw8o4g 115 36 0.05 0.05 CD cord-256343-dtfw8o4g 115 37 , , , cord-256343-dtfw8o4g 115 38 with with IN cord-256343-dtfw8o4g 115 39 mean mean JJ cord-256343-dtfw8o4g 115 40 values value NNS cord-256343-dtfw8o4g 115 41 of of IN cord-256343-dtfw8o4g 115 42 0.99 0.99 CD cord-256343-dtfw8o4g 115 43 for for IN cord-256343-dtfw8o4g 115 44 each each DT cord-256343-dtfw8o4g 115 45 gene gene NN cord-256343-dtfw8o4g 115 46 and and CC cord-256343-dtfw8o4g 115 47 sd sd NN cord-256343-dtfw8o4g 115 48 values value NNS cord-256343-dtfw8o4g 115 49 of of IN cord-256343-dtfw8o4g 115 50 0.06 0.06 CD cord-256343-dtfw8o4g 115 51 , , , cord-256343-dtfw8o4g 115 52 0.05 0.05 CD cord-256343-dtfw8o4g 115 53 and and CC cord-256343-dtfw8o4g 115 54 0.08 0.08 CD cord-256343-dtfw8o4g 115 55 , , , cord-256343-dtfw8o4g 115 56 respectively respectively RB cord-256343-dtfw8o4g 115 57 . . . cord-256343-dtfw8o4g 116 1 For for IN cord-256343-dtfw8o4g 116 2 S s NN cord-256343-dtfw8o4g 116 3 sequences sequence NNS cord-256343-dtfw8o4g 116 4 , , , cord-256343-dtfw8o4g 116 5 the the DT cord-256343-dtfw8o4g 116 6 mean mean NN cord-256343-dtfw8o4g 116 7 p p NN cord-256343-dtfw8o4g 116 8 value value NN cord-256343-dtfw8o4g 116 9 was be VBD cord-256343-dtfw8o4g 116 10 0.97 0.97 CD cord-256343-dtfw8o4g 116 11 ( ( -LRB- cord-256343-dtfw8o4g 116 12 sd sd NNP cord-256343-dtfw8o4g 116 13 0.13 0.13 CD cord-256343-dtfw8o4g 116 14 ) ) -RRB- cord-256343-dtfw8o4g 116 15 , , , cord-256343-dtfw8o4g 116 16 but but CC cord-256343-dtfw8o4g 116 17 p p NN cord-256343-dtfw8o4g 116 18 values value NNS cord-256343-dtfw8o4g 116 19 < < XX cord-256343-dtfw8o4g 116 20 0.05 0.05 CD cord-256343-dtfw8o4g 116 21 were be VBD cord-256343-dtfw8o4g 116 22 found find VBN cord-256343-dtfw8o4g 116 23 between between IN cord-256343-dtfw8o4g 116 24 _SP cord-256343-dtfw8o4g 116 25 Regardless Regardless NNP cord-256343-dtfw8o4g 116 26 of of IN cord-256343-dtfw8o4g 116 27 the the DT cord-256343-dtfw8o4g 116 28 gene gene NN cord-256343-dtfw8o4g 116 29 being be VBG cord-256343-dtfw8o4g 116 30 considered consider VBN cord-256343-dtfw8o4g 116 31 , , , cord-256343-dtfw8o4g 116 32 all all DT cord-256343-dtfw8o4g 116 33 A. a. NN cord-256343-dtfw8o4g 116 34 coronavirus coronavirus NN cord-256343-dtfw8o4g 116 35 sequences sequence NNS cord-256343-dtfw8o4g 116 36 segregated segregate VBN cord-256343-dtfw8o4g 116 37 in in IN cord-256343-dtfw8o4g 116 38 an an DT cord-256343-dtfw8o4g 116 39 exclusive exclusive JJ cord-256343-dtfw8o4g 116 40 cluster cluster NN cord-256343-dtfw8o4g 116 41 in in IN cord-256343-dtfw8o4g 116 42 the the DT cord-256343-dtfw8o4g 116 43 RSCU RSCU NNP cord-256343-dtfw8o4g 116 44 tree tree NN cord-256343-dtfw8o4g 116 45 , , , cord-256343-dtfw8o4g 116 46 which which WDT cord-256343-dtfw8o4g 116 47 , , , cord-256343-dtfw8o4g 116 48 despite despite IN cord-256343-dtfw8o4g 116 49 being be VBG cord-256343-dtfw8o4g 116 50 consistently consistently RB cord-256343-dtfw8o4g 116 51 separate separate JJ cord-256343-dtfw8o4g 116 52 from from IN cord-256343-dtfw8o4g 116 53 the the DT cord-256343-dtfw8o4g 116 54 G. G. NNP cord-256343-dtfw8o4g 116 55 gallus gallus NN cord-256343-dtfw8o4g 116 56 cluster cluster NN cord-256343-dtfw8o4g 116 57 , , , cord-256343-dtfw8o4g 116 58 was be VBD cord-256343-dtfw8o4g 116 59 closer close JJR cord-256343-dtfw8o4g 116 60 to to IN cord-256343-dtfw8o4g 116 61 the the DT cord-256343-dtfw8o4g 116 62 SFTPA1 sftpa1 NN cord-256343-dtfw8o4g 117 1 ( ( -LRB- cord-256343-dtfw8o4g 117 2 a a DT cord-256343-dtfw8o4g 117 3 gene gene NN cord-256343-dtfw8o4g 117 4 expressed express VBN cord-256343-dtfw8o4g 117 5 in in IN cord-256343-dtfw8o4g 117 6 the the DT cord-256343-dtfw8o4g 117 7 respiratory respiratory JJ cord-256343-dtfw8o4g 117 8 tract tract NN cord-256343-dtfw8o4g 117 9 of of IN cord-256343-dtfw8o4g 117 10 chicken chicken NN cord-256343-dtfw8o4g 117 11 ) ) -RRB- cord-256343-dtfw8o4g 117 12 cluster cluster NN cord-256343-dtfw8o4g 117 13 . . . cord-256343-dtfw8o4g 118 1 Taking take VBG cord-256343-dtfw8o4g 118 2 the the DT cord-256343-dtfw8o4g 118 3 codon codon NN cord-256343-dtfw8o4g 118 4 usage usage NN cord-256343-dtfw8o4g 118 5 for for IN cord-256343-dtfw8o4g 118 6 these these DT cord-256343-dtfw8o4g 118 7 genes gene NNS cord-256343-dtfw8o4g 118 8 as as IN cord-256343-dtfw8o4g 118 9 a a DT cord-256343-dtfw8o4g 118 10 reflection reflection NN cord-256343-dtfw8o4g 118 11 of of IN cord-256343-dtfw8o4g 118 12 the the DT cord-256343-dtfw8o4g 118 13 codon codon NN cord-256343-dtfw8o4g 118 14 usage usage NN cord-256343-dtfw8o4g 118 15 in in IN cord-256343-dtfw8o4g 118 16 the the DT cord-256343-dtfw8o4g 118 17 respiratory respiratory JJ cord-256343-dtfw8o4g 118 18 tract tract NN cord-256343-dtfw8o4g 118 19 , , , cord-256343-dtfw8o4g 118 20 both both DT cord-256343-dtfw8o4g 118 21 structural structural JJ cord-256343-dtfw8o4g 118 22 and and CC cord-256343-dtfw8o4g 118 23 non non JJ cord-256343-dtfw8o4g 118 24 - - JJ cord-256343-dtfw8o4g 118 25 structural structural JJ cord-256343-dtfw8o4g 118 26 genes gene NNS cord-256343-dtfw8o4g 118 27 show show VBP cord-256343-dtfw8o4g 118 28 a a DT cord-256343-dtfw8o4g 118 29 codon codon NN cord-256343-dtfw8o4g 118 30 usage usage NN cord-256343-dtfw8o4g 118 31 closer close RBR cord-256343-dtfw8o4g 118 32 to to IN cord-256343-dtfw8o4g 118 33 the the DT cord-256343-dtfw8o4g 118 34 chicken chicken NN cord-256343-dtfw8o4g 118 35 respiratory respiratory JJ cord-256343-dtfw8o4g 118 36 tissue tissue NN cord-256343-dtfw8o4g 118 37 translational translational JJ cord-256343-dtfw8o4g 118 38 environment environment NN cord-256343-dtfw8o4g 118 39 than than IN cord-256343-dtfw8o4g 118 40 to to IN cord-256343-dtfw8o4g 118 41 the the DT cord-256343-dtfw8o4g 118 42 reproductive reproductive JJ cord-256343-dtfw8o4g 118 43 , , , cord-256343-dtfw8o4g 118 44 renal renal JJ cord-256343-dtfw8o4g 118 45 and and CC cord-256343-dtfw8o4g 118 46 enteric enteric JJ cord-256343-dtfw8o4g 118 47 ones one NNS cord-256343-dtfw8o4g 118 48 . . . cord-256343-dtfw8o4g 119 1 This this DT cord-256343-dtfw8o4g 119 2 similar similar JJ cord-256343-dtfw8o4g 119 3 codon codon NN cord-256343-dtfw8o4g 119 4 usage usage NN cord-256343-dtfw8o4g 119 5 could could MD cord-256343-dtfw8o4g 119 6 allow allow VB cord-256343-dtfw8o4g 119 7 for for IN cord-256343-dtfw8o4g 119 8 an an DT cord-256343-dtfw8o4g 119 9 improved improve VBN cord-256343-dtfw8o4g 119 10 viral viral JJ cord-256343-dtfw8o4g 119 11 replication replication NN cord-256343-dtfw8o4g 119 12 in in IN cord-256343-dtfw8o4g 119 13 the the DT cord-256343-dtfw8o4g 119 14 respiratory respiratory JJ cord-256343-dtfw8o4g 119 15 tract tract NN cord-256343-dtfw8o4g 119 16 as as IN cord-256343-dtfw8o4g 119 17 a a DT cord-256343-dtfw8o4g 119 18 first first JJ cord-256343-dtfw8o4g 119 19 site site NN cord-256343-dtfw8o4g 119 20 of of IN cord-256343-dtfw8o4g 119 21 viral viral JJ cord-256343-dtfw8o4g 119 22 replication replication NN cord-256343-dtfw8o4g 119 23 , , , cord-256343-dtfw8o4g 119 24 a a DT cord-256343-dtfw8o4g 119 25 feature feature NN cord-256343-dtfw8o4g 119 26 common common JJ cord-256343-dtfw8o4g 119 27 to to IN cord-256343-dtfw8o4g 119 28 all all DT cord-256343-dtfw8o4g 119 29 A. a. NN cord-256343-dtfw8o4g 119 30 coronavirus coronavirus NN cord-256343-dtfw8o4g 119 31 strains strain NNS cord-256343-dtfw8o4g 119 32 in in IN cord-256343-dtfw8o4g 119 33 chickens chicken NNS cord-256343-dtfw8o4g 119 34 , , , cord-256343-dtfw8o4g 119 35 before before IN cord-256343-dtfw8o4g 119 36 the the DT cord-256343-dtfw8o4g 119 37 virus virus NN cord-256343-dtfw8o4g 119 38 reaches reach VBZ cord-256343-dtfw8o4g 119 39 other other JJ cord-256343-dtfw8o4g 119 40 replication replication NN cord-256343-dtfw8o4g 119 41 sites site NNS cord-256343-dtfw8o4g 119 42 for for IN cord-256343-dtfw8o4g 119 43 each each DT cord-256343-dtfw8o4g 119 44 pathotype pathotype NN cord-256343-dtfw8o4g 119 45 , , , cord-256343-dtfw8o4g 119 46 as as IN cord-256343-dtfw8o4g 119 47 a a DT cord-256343-dtfw8o4g 119 48 result result NN cord-256343-dtfw8o4g 119 49 of of IN cord-256343-dtfw8o4g 119 50 the the DT cord-256343-dtfw8o4g 119 51 natural natural JJ cord-256343-dtfw8o4g 119 52 selection selection NN cord-256343-dtfw8o4g 119 53 for for IN cord-256343-dtfw8o4g 119 54 codons codon NNS cord-256343-dtfw8o4g 119 55 and and CC cord-256343-dtfw8o4g 119 56 a a DT cord-256343-dtfw8o4g 119 57 more more RBR cord-256343-dtfw8o4g 119 58 efficient efficient JJ cord-256343-dtfw8o4g 119 59 translation translation NN cord-256343-dtfw8o4g 119 60 of of IN cord-256343-dtfw8o4g 119 61 virus virus NN cord-256343-dtfw8o4g 119 62 proteins protein NNS cord-256343-dtfw8o4g 119 63 , , , cord-256343-dtfw8o4g 119 64 as as RB cord-256343-dtfw8o4g 119 65 already already RB cord-256343-dtfw8o4g 119 66 suggested suggest VBN cord-256343-dtfw8o4g 119 67 for for IN cord-256343-dtfw8o4g 119 68 the the DT cord-256343-dtfw8o4g 119 69 S S NNP cord-256343-dtfw8o4g 119 70 gene gene NN cord-256343-dtfw8o4g 119 71 alone alone RB cord-256343-dtfw8o4g 119 72 ( ( -LRB- cord-256343-dtfw8o4g 119 73 Brandão Brandão NNP cord-256343-dtfw8o4g 119 74 , , , cord-256343-dtfw8o4g 119 75 2012 2012 CD cord-256343-dtfw8o4g 119 76 ) ) -RRB- cord-256343-dtfw8o4g 119 77 . . . cord-256343-dtfw8o4g 120 1 Evidence evidence NN cord-256343-dtfw8o4g 120 2 of of IN cord-256343-dtfw8o4g 120 3 natural natural JJ cord-256343-dtfw8o4g 120 4 selection selection NN cord-256343-dtfw8o4g 120 5 for for IN cord-256343-dtfw8o4g 120 6 codon codon NN cord-256343-dtfw8o4g 120 7 usage usage NN cord-256343-dtfw8o4g 120 8 as as IN cord-256343-dtfw8o4g 120 9 an an DT cord-256343-dtfw8o4g 120 10 evolutionary evolutionary JJ cord-256343-dtfw8o4g 120 11 force force NN cord-256343-dtfw8o4g 120 12 acting act VBG cord-256343-dtfw8o4g 120 13 upon upon IN cord-256343-dtfw8o4g 120 14 A. a. NN cord-256343-dtfw8o4g 120 15 coronavirus coronavirus NN cord-256343-dtfw8o4g 120 16 was be VBD cord-256343-dtfw8o4g 120 17 found find VBN cord-256343-dtfw8o4g 120 18 in in IN cord-256343-dtfw8o4g 120 19 the the DT cord-256343-dtfw8o4g 120 20 Nc Nc NNP cord-256343-dtfw8o4g 120 21 × × NNP cord-256343-dtfw8o4g 120 22 GC GC NNP cord-256343-dtfw8o4g 120 23 3 3 CD cord-256343-dtfw8o4g 120 24 % % NN cord-256343-dtfw8o4g 120 25 graphs graph NNS cord-256343-dtfw8o4g 120 26 ( ( -LRB- cord-256343-dtfw8o4g 120 27 Fig fig NN cord-256343-dtfw8o4g 120 28 . . NNP cord-256343-dtfw8o4g 120 29 2 2 CD cord-256343-dtfw8o4g 120 30 ) ) -RRB- cord-256343-dtfw8o4g 121 1 because because IN cord-256343-dtfw8o4g 121 2 for for IN cord-256343-dtfw8o4g 121 3 all all DT cord-256343-dtfw8o4g 121 4 four four CD cord-256343-dtfw8o4g 121 5 viral viral JJ cord-256343-dtfw8o4g 121 6 genes gene NNS cord-256343-dtfw8o4g 121 7 , , , cord-256343-dtfw8o4g 121 8 observed observe VBD cord-256343-dtfw8o4g 121 9 GC GC NNP cord-256343-dtfw8o4g 121 10 3 3 CD cord-256343-dtfw8o4g 121 11 % % NN cord-256343-dtfw8o4g 121 12 points point NNS cord-256343-dtfw8o4g 121 13 fell fall VBD cord-256343-dtfw8o4g 121 14 outside outside IN cord-256343-dtfw8o4g 121 15 the the DT cord-256343-dtfw8o4g 121 16 curve curve NN cord-256343-dtfw8o4g 121 17 , , , cord-256343-dtfw8o4g 121 18 indicating indicate VBG cord-256343-dtfw8o4g 121 19 that that IN cord-256343-dtfw8o4g 121 20 codon codon NN cord-256343-dtfw8o4g 121 21 usage usage NN cord-256343-dtfw8o4g 121 22 for for IN cord-256343-dtfw8o4g 121 23 all all PDT cord-256343-dtfw8o4g 121 24 the the DT cord-256343-dtfw8o4g 121 25 strains strain NNS cord-256343-dtfw8o4g 121 26 under under IN cord-256343-dtfw8o4g 121 27 analysis analysis NN cord-256343-dtfw8o4g 121 28 was be VBD cord-256343-dtfw8o4g 121 29 not not RB cord-256343-dtfw8o4g 121 30 the the DT cord-256343-dtfw8o4g 121 31 sole sole JJ cord-256343-dtfw8o4g 121 32 result result NN cord-256343-dtfw8o4g 121 33 of of IN cord-256343-dtfw8o4g 121 34 the the DT cord-256343-dtfw8o4g 121 35 random random JJ cord-256343-dtfw8o4g 121 36 accumulation accumulation NN cord-256343-dtfw8o4g 121 37 of of IN cord-256343-dtfw8o4g 121 38 mutations mutation NNS cord-256343-dtfw8o4g 121 39 . . . cord-256343-dtfw8o4g 122 1 Nonetheless nonetheless RB cord-256343-dtfw8o4g 122 2 , , , cord-256343-dtfw8o4g 122 3 the the DT cord-256343-dtfw8o4g 122 4 Nc Nc NNP cord-256343-dtfw8o4g 122 5 × × NNP cord-256343-dtfw8o4g 122 6 GC GC NNP cord-256343-dtfw8o4g 122 7 3 3 CD cord-256343-dtfw8o4g 122 8 % % NN cord-256343-dtfw8o4g 122 9 plots plot NNS cord-256343-dtfw8o4g 122 10 show show VBP cord-256343-dtfw8o4g 122 11 that that IN cord-256343-dtfw8o4g 122 12 A. A. NNP cord-256343-dtfw8o4g 122 13 coronavirus coronavirus NN cord-256343-dtfw8o4g 122 14 codon codon NN cord-256343-dtfw8o4g 122 15 usage usage NN cord-256343-dtfw8o4g 122 16 could could MD cord-256343-dtfw8o4g 122 17 also also RB cord-256343-dtfw8o4g 122 18 be be VB cord-256343-dtfw8o4g 122 19 a a DT cord-256343-dtfw8o4g 122 20 consequence consequence NN cord-256343-dtfw8o4g 122 21 of of IN cord-256343-dtfw8o4g 122 22 mutation mutation NN cord-256343-dtfw8o4g 122 23 pressure pressure NN cord-256343-dtfw8o4g 122 24 , , , cord-256343-dtfw8o4g 122 25 as as IN cord-256343-dtfw8o4g 122 26 the the DT cord-256343-dtfw8o4g 122 27 points point NNS cord-256343-dtfw8o4g 122 28 were be VBD cord-256343-dtfw8o4g 122 29 in in IN cord-256343-dtfw8o4g 122 30 the the DT cord-256343-dtfw8o4g 122 31 vicinity vicinity NN cord-256343-dtfw8o4g 122 32 of of IN cord-256343-dtfw8o4g 122 33 the the DT cord-256343-dtfw8o4g 122 34 curve curve NN cord-256343-dtfw8o4g 122 35 , , , cord-256343-dtfw8o4g 122 36 meaning mean VBG cord-256343-dtfw8o4g 122 37 that that IN cord-256343-dtfw8o4g 122 38 the the DT cord-256343-dtfw8o4g 122 39 GC% GC% NNP cord-256343-dtfw8o4g 122 40 at at IN cord-256343-dtfw8o4g 122 41 the the DT cord-256343-dtfw8o4g 122 42 synonymous synonymous JJ cord-256343-dtfw8o4g 122 43 3rd 3rd JJ cord-256343-dtfw8o4g 122 44 codon codon NN cord-256343-dtfw8o4g 122 45 position position NN cord-256343-dtfw8o4g 122 46 follows follow VBZ cord-256343-dtfw8o4g 122 47 the the DT cord-256343-dtfw8o4g 122 48 viral viral JJ cord-256343-dtfw8o4g 122 49 genomic genomic JJ cord-256343-dtfw8o4g 122 50 GC% gc% NN cord-256343-dtfw8o4g 122 51 to to IN cord-256343-dtfw8o4g 122 52 some some DT cord-256343-dtfw8o4g 122 53 degree degree NN cord-256343-dtfw8o4g 122 54 . . . cord-256343-dtfw8o4g 123 1 It -PRON- PRP cord-256343-dtfw8o4g 123 2 must must MD cord-256343-dtfw8o4g 123 3 be be VB cord-256343-dtfw8o4g 123 4 considered consider VBN cord-256343-dtfw8o4g 123 5 that that IN cord-256343-dtfw8o4g 123 6 both both DT cord-256343-dtfw8o4g 123 7 genetic genetic JJ cord-256343-dtfw8o4g 123 8 drift drift NN cord-256343-dtfw8o4g 123 9 derived derive VBN cord-256343-dtfw8o4g 123 10 from from IN cord-256343-dtfw8o4g 123 11 the the DT cord-256343-dtfw8o4g 123 12 mutation mutation NN cord-256343-dtfw8o4g 123 13 pressure pressure NN cord-256343-dtfw8o4g 123 14 and and CC cord-256343-dtfw8o4g 123 15 natural natural JJ cord-256343-dtfw8o4g 123 16 selection selection NN cord-256343-dtfw8o4g 123 17 detected detect VBN cord-256343-dtfw8o4g 123 18 for for IN cord-256343-dtfw8o4g 123 19 A. a. NN cord-256343-dtfw8o4g 123 20 coronavirus coronavirus NN cord-256343-dtfw8o4g 123 21 could could MD cord-256343-dtfw8o4g 123 22 also also RB cord-256343-dtfw8o4g 123 23 harbor harbor VB cord-256343-dtfw8o4g 123 24 some some DT cord-256343-dtfw8o4g 123 25 relationship relationship NN cord-256343-dtfw8o4g 123 26 with with IN cord-256343-dtfw8o4g 123 27 genomic genomic JJ cord-256343-dtfw8o4g 123 28 RNA RNA NNP cord-256343-dtfw8o4g 123 29 secondary secondary JJ cord-256343-dtfw8o4g 123 30 structure structure NN cord-256343-dtfw8o4g 123 31 constraints constraint NNS cord-256343-dtfw8o4g 123 32 and and CC cord-256343-dtfw8o4g 123 33 not not RB cord-256343-dtfw8o4g 123 34 only only RB cord-256343-dtfw8o4g 123 35 codon codon NN cord-256343-dtfw8o4g 123 36 usage usage NN cord-256343-dtfw8o4g 123 37 , , , cord-256343-dtfw8o4g 123 38 as as IN cord-256343-dtfw8o4g 123 39 synonymous synonymous JJ cord-256343-dtfw8o4g 123 40 3rd 3rd JJ cord-256343-dtfw8o4g 123 41 base base NN cord-256343-dtfw8o4g 123 42 mutations mutation NNS cord-256343-dtfw8o4g 123 43 , , , cord-256343-dtfw8o4g 123 44 though though IN cord-256343-dtfw8o4g 123 45 synonymous synonymous JJ cord-256343-dtfw8o4g 123 46 in in IN cord-256343-dtfw8o4g 123 47 terms term NNS cord-256343-dtfw8o4g 123 48 of of IN cord-256343-dtfw8o4g 123 49 amino amino NN cord-256343-dtfw8o4g 123 50 acid acid NN cord-256343-dtfw8o4g 123 51 codification codification NN cord-256343-dtfw8o4g 123 52 , , , cord-256343-dtfw8o4g 123 53 could could MD cord-256343-dtfw8o4g 123 54 result result VB cord-256343-dtfw8o4g 123 55 in in IN cord-256343-dtfw8o4g 123 56 altered alter VBN cord-256343-dtfw8o4g 123 57 RNA RNA NNP cord-256343-dtfw8o4g 123 58 secondary secondary JJ cord-256343-dtfw8o4g 123 59 structure structure NN cord-256343-dtfw8o4g 123 60 ( ( -LRB- cord-256343-dtfw8o4g 123 61 Cardinale Cardinale NNP cord-256343-dtfw8o4g 123 62 et et FW cord-256343-dtfw8o4g 123 63 al al NNP cord-256343-dtfw8o4g 123 64 . . NNP cord-256343-dtfw8o4g 123 65 , , , cord-256343-dtfw8o4g 123 66 2013 2013 CD cord-256343-dtfw8o4g 123 67 ) ) -RRB- cord-256343-dtfw8o4g 123 68 and and CC cord-256343-dtfw8o4g 123 69 , , , cord-256343-dtfw8o4g 123 70 consequently consequently RB cord-256343-dtfw8o4g 123 71 , , , cord-256343-dtfw8o4g 123 72 impaired impair VBN cord-256343-dtfw8o4g 123 73 viral viral JJ cord-256343-dtfw8o4g 123 74 transcription transcription NN cord-256343-dtfw8o4g 123 75 , , , cord-256343-dtfw8o4g 123 76 replication replication NN cord-256343-dtfw8o4g 123 77 and and CC cord-256343-dtfw8o4g 123 78 assembly assembly NN cord-256343-dtfw8o4g 123 79 . . . cord-256343-dtfw8o4g 124 1 As as IN cord-256343-dtfw8o4g 124 2 signals signal NNS cord-256343-dtfw8o4g 124 3 for for IN cord-256343-dtfw8o4g 124 4 RNA RNA NNP cord-256343-dtfw8o4g 124 5 replication replication NN cord-256343-dtfw8o4g 124 6 and and CC cord-256343-dtfw8o4g 124 7 genome genome NN cord-256343-dtfw8o4g 124 8 packaging packaging NN cord-256343-dtfw8o4g 124 9 in in IN cord-256343-dtfw8o4g 124 10 coronaviruses coronaviruse NNS cord-256343-dtfw8o4g 124 11 are be VBP cord-256343-dtfw8o4g 124 12 RNA RNA NNP cord-256343-dtfw8o4g 124 13 secondary secondary JJ cord-256343-dtfw8o4g 124 14 structuredependent structuredependent NN cord-256343-dtfw8o4g 124 15 ( ( -LRB- cord-256343-dtfw8o4g 124 16 Narayanan Narayanan NNP cord-256343-dtfw8o4g 124 17 and and CC cord-256343-dtfw8o4g 124 18 Makino Makino NNP cord-256343-dtfw8o4g 124 19 , , , cord-256343-dtfw8o4g 124 20 2007 2007 CD cord-256343-dtfw8o4g 124 21 ; ; . cord-256343-dtfw8o4g 125 1 Williams Williams NNP cord-256343-dtfw8o4g 125 2 et et NNP cord-256343-dtfw8o4g 125 3 al al NNP cord-256343-dtfw8o4g 125 4 . . NNP cord-256343-dtfw8o4g 125 5 , , , cord-256343-dtfw8o4g 125 6 1999 1999 CD cord-256343-dtfw8o4g 125 7 ) ) -RRB- cord-256343-dtfw8o4g 125 8 , , , cord-256343-dtfw8o4g 125 9 such such JJ cord-256343-dtfw8o4g 125 10 structures structure NNS cord-256343-dtfw8o4g 125 11 must must MD cord-256343-dtfw8o4g 125 12 be be VB cord-256343-dtfw8o4g 125 13 under under IN cord-256343-dtfw8o4g 125 14 intense intense JJ cord-256343-dtfw8o4g 125 15 evolutionary evolutionary JJ cord-256343-dtfw8o4g 125 16 constraints constraint NNS cord-256343-dtfw8o4g 125 17 that that WDT cord-256343-dtfw8o4g 125 18 balance balance VBP cord-256343-dtfw8o4g 125 19 with with IN cord-256343-dtfw8o4g 125 20 codon codon NN cord-256343-dtfw8o4g 125 21 usage usage NN cord-256343-dtfw8o4g 125 22 evolution evolution NN cord-256343-dtfw8o4g 125 23 . . . cord-256343-dtfw8o4g 126 1 From from IN cord-256343-dtfw8o4g 126 2 the the DT cord-256343-dtfw8o4g 126 3 host host NN cord-256343-dtfw8o4g 126 4 side side NN cord-256343-dtfw8o4g 126 5 , , , cord-256343-dtfw8o4g 126 6 mutation mutation NN cord-256343-dtfw8o4g 126 7 bias bias NN cord-256343-dtfw8o4g 126 8 has have VBZ cord-256343-dtfw8o4g 126 9 also also RB cord-256343-dtfw8o4g 126 10 been be VBN cord-256343-dtfw8o4g 126 11 shown show VBN cord-256343-dtfw8o4g 126 12 to to TO cord-256343-dtfw8o4g 126 13 be be VB cord-256343-dtfw8o4g 126 14 the the DT cord-256343-dtfw8o4g 126 15 major major JJ cord-256343-dtfw8o4g 126 16 driving drive VBG cord-256343-dtfw8o4g 126 17 force force NN cord-256343-dtfw8o4g 126 18 of of IN cord-256343-dtfw8o4g 126 19 G. G. NNP cord-256343-dtfw8o4g 126 20 gallus gallus NN cord-256343-dtfw8o4g 126 21 codon codon NN cord-256343-dtfw8o4g 126 22 usage usage NN cord-256343-dtfw8o4g 126 23 evolution evolution NN cord-256343-dtfw8o4g 126 24 , , , cord-256343-dtfw8o4g 126 25 with with IN cord-256343-dtfw8o4g 126 26 minor minor JJ cord-256343-dtfw8o4g 126 27 participation participation NN cord-256343-dtfw8o4g 126 28 of of IN cord-256343-dtfw8o4g 126 29 natural natural JJ cord-256343-dtfw8o4g 126 30 selection selection NN cord-256343-dtfw8o4g 127 1 ( ( -LRB- cord-256343-dtfw8o4g 127 2 Rao Rao NNP cord-256343-dtfw8o4g 127 3 et et NNP cord-256343-dtfw8o4g 127 4 al al NNP cord-256343-dtfw8o4g 127 5 . . NNP cord-256343-dtfw8o4g 127 6 , , , cord-256343-dtfw8o4g 127 7 2011 2011 CD cord-256343-dtfw8o4g 127 8 ) ) -RRB- cord-256343-dtfw8o4g 127 9 , , , cord-256343-dtfw8o4g 127 10 in in IN cord-256343-dtfw8o4g 127 11 agreement agreement NN cord-256343-dtfw8o4g 127 12 with with IN cord-256343-dtfw8o4g 127 13 the the DT cord-256343-dtfw8o4g 127 14 results result NNS cord-256343-dtfw8o4g 127 15 presented present VBN cord-256343-dtfw8o4g 127 16 herein herein RB cord-256343-dtfw8o4g 127 17 , , , cord-256343-dtfw8o4g 128 1 suggesting suggest VBG cord-256343-dtfw8o4g 128 2 a a DT cord-256343-dtfw8o4g 128 3 common common JJ cord-256343-dtfw8o4g 128 4 evolutionary evolutionary JJ cord-256343-dtfw8o4g 128 5 path path NN cord-256343-dtfw8o4g 128 6 for for IN cord-256343-dtfw8o4g 128 7 both both DT cord-256343-dtfw8o4g 128 8 virus virus NN cord-256343-dtfw8o4g 128 9 and and CC cord-256343-dtfw8o4g 128 10 host host NN cord-256343-dtfw8o4g 128 11 . . . cord-256343-dtfw8o4g 129 1 A a DT cord-256343-dtfw8o4g 129 2 marked marked JJ cord-256343-dtfw8o4g 129 3 difference difference NN cord-256343-dtfw8o4g 129 4 was be VBD cord-256343-dtfw8o4g 129 5 noticed notice VBN cord-256343-dtfw8o4g 129 6 regarding regard VBG cord-256343-dtfw8o4g 129 7 the the DT cord-256343-dtfw8o4g 129 8 degree degree NN cord-256343-dtfw8o4g 129 9 of of IN cord-256343-dtfw8o4g 129 10 codon codon NN cord-256343-dtfw8o4g 129 11 usage usage NN cord-256343-dtfw8o4g 129 12 bias bias NN cord-256343-dtfw8o4g 129 13 for for IN cord-256343-dtfw8o4g 129 14 each each DT cord-256343-dtfw8o4g 129 15 A. a. NN cord-256343-dtfw8o4g 129 16 coronavirus coronavirus NN cord-256343-dtfw8o4g 129 17 gene gene NN cord-256343-dtfw8o4g 129 18 studied study VBD cord-256343-dtfw8o4g 129 19 : : : cord-256343-dtfw8o4g 129 20 for for IN cord-256343-dtfw8o4g 129 21 S S NNP cord-256343-dtfw8o4g 129 22 , , , cord-256343-dtfw8o4g 129 23 N N NNP cord-256343-dtfw8o4g 129 24 and and CC cord-256343-dtfw8o4g 129 25 PL PL NNP cord-256343-dtfw8o4g 129 26 pro pro UH cord-256343-dtfw8o4g 129 27 , , , cord-256343-dtfw8o4g 129 28 all all DT cord-256343-dtfw8o4g 129 29 mean mean JJ cord-256343-dtfw8o4g 129 30 values value NNS cord-256343-dtfw8o4g 129 31 were be VBD cord-256343-dtfw8o4g 129 32 just just RB cord-256343-dtfw8o4g 129 33 above above IN cord-256343-dtfw8o4g 129 34 40 40 CD cord-256343-dtfw8o4g 129 35 , , , cord-256343-dtfw8o4g 129 36 indicating indicate VBG cord-256343-dtfw8o4g 129 37 a a DT cord-256343-dtfw8o4g 129 38 moderate moderate JJ cord-256343-dtfw8o4g 129 39 bias bias NN cord-256343-dtfw8o4g 129 40 ( ( -LRB- cord-256343-dtfw8o4g 129 41 Gu Gu NNP cord-256343-dtfw8o4g 129 42 et et FW cord-256343-dtfw8o4g 129 43 al al NNP cord-256343-dtfw8o4g 129 44 . . NNP cord-256343-dtfw8o4g 129 45 , , , cord-256343-dtfw8o4g 129 46 2004 2004 CD cord-256343-dtfw8o4g 129 47 ) ) -RRB- cord-256343-dtfw8o4g 129 48 , , , cord-256343-dtfw8o4g 129 49 but but CC cord-256343-dtfw8o4g 129 50 for for IN cord-256343-dtfw8o4g 129 51 NSP2 NSP2 NNP cord-256343-dtfw8o4g 129 52 , , , cord-256343-dtfw8o4g 129 53 the the DT cord-256343-dtfw8o4g 129 54 mean mean JJ cord-256343-dtfw8o4g 129 55 Nc Nc NNP cord-256343-dtfw8o4g 129 56 ( ( -LRB- cord-256343-dtfw8o4g 129 57 53.01 53.01 CD cord-256343-dtfw8o4g 129 58 ) ) -RRB- cord-256343-dtfw8o4g 129 59 indicated indicate VBD cord-256343-dtfw8o4g 129 60 a a DT cord-256343-dtfw8o4g 129 61 lower low JJR cord-256343-dtfw8o4g 129 62 codon codon NN cord-256343-dtfw8o4g 129 63 usage usage NN cord-256343-dtfw8o4g 129 64 bias bias NN cord-256343-dtfw8o4g 129 65 . . . cord-256343-dtfw8o4g 130 1 These these DT cord-256343-dtfw8o4g 130 2 results result NNS cord-256343-dtfw8o4g 130 3 provide provide VBP cord-256343-dtfw8o4g 130 4 evidence evidence NN cord-256343-dtfw8o4g 130 5 that that IN cord-256343-dtfw8o4g 130 6 A. a. NN cord-256343-dtfw8o4g 130 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 130 8 genes gene NNS cord-256343-dtfw8o4g 130 9 have have VBP cord-256343-dtfw8o4g 130 10 taken take VBN cord-256343-dtfw8o4g 130 11 different different JJ cord-256343-dtfw8o4g 130 12 codon codon NN cord-256343-dtfw8o4g 130 13 evolution evolution NN cord-256343-dtfw8o4g 130 14 pathways pathway NNS cord-256343-dtfw8o4g 130 15 depending depend VBG cord-256343-dtfw8o4g 130 16 on on IN cord-256343-dtfw8o4g 130 17 the the DT cord-256343-dtfw8o4g 130 18 function function NN cord-256343-dtfw8o4g 130 19 that that IN cord-256343-dtfw8o4g 130 20 each each DT cord-256343-dtfw8o4g 130 21 protein protein NN cord-256343-dtfw8o4g 130 22 possesses possess VBZ cord-256343-dtfw8o4g 130 23 . . . cord-256343-dtfw8o4g 131 1 The the DT cord-256343-dtfw8o4g 131 2 function function NN cord-256343-dtfw8o4g 131 3 of of IN cord-256343-dtfw8o4g 131 4 NSP2 NSP2 NNP cord-256343-dtfw8o4g 131 5 is be VBZ cord-256343-dtfw8o4g 131 6 still still RB cord-256343-dtfw8o4g 131 7 not not RB cord-256343-dtfw8o4g 131 8 clearly clearly RB cord-256343-dtfw8o4g 131 9 defined define VBN cord-256343-dtfw8o4g 131 10 , , , cord-256343-dtfw8o4g 131 11 but but CC cord-256343-dtfw8o4g 131 12 a a DT cord-256343-dtfw8o4g 131 13 role role NN cord-256343-dtfw8o4g 131 14 has have VBZ cord-256343-dtfw8o4g 131 15 been be VBN cord-256343-dtfw8o4g 131 16 suggested suggest VBN cord-256343-dtfw8o4g 131 17 as as IN cord-256343-dtfw8o4g 131 18 a a DT cord-256343-dtfw8o4g 131 19 co co NN cord-256343-dtfw8o4g 131 20 - - NN cord-256343-dtfw8o4g 131 21 factor factor NN cord-256343-dtfw8o4g 131 22 for for IN cord-256343-dtfw8o4g 131 23 RNA RNA NNP cord-256343-dtfw8o4g 131 24 synthesis synthesis NN cord-256343-dtfw8o4g 131 25 ( ( -LRB- cord-256343-dtfw8o4g 131 26 Graham Graham NNP cord-256343-dtfw8o4g 131 27 et et NNP cord-256343-dtfw8o4g 131 28 al al NNP cord-256343-dtfw8o4g 131 29 . . NNP cord-256343-dtfw8o4g 131 30 , , , cord-256343-dtfw8o4g 131 31 2005 2005 CD cord-256343-dtfw8o4g 131 32 ) ) -RRB- cord-256343-dtfw8o4g 131 33 , , , cord-256343-dtfw8o4g 131 34 possibly possibly RB cord-256343-dtfw8o4g 131 35 in in IN cord-256343-dtfw8o4g 131 36 the the DT cord-256343-dtfw8o4g 131 37 early early JJ cord-256343-dtfw8o4g 131 38 stages stage NNS cord-256343-dtfw8o4g 131 39 of of IN cord-256343-dtfw8o4g 131 40 virus virus NN cord-256343-dtfw8o4g 131 41 replication replication NN cord-256343-dtfw8o4g 131 42 . . . cord-256343-dtfw8o4g 132 1 Despite despite IN cord-256343-dtfw8o4g 132 2 the the DT cord-256343-dtfw8o4g 132 3 limited limited JJ cord-256343-dtfw8o4g 132 4 number number NN cord-256343-dtfw8o4g 132 5 of of IN cord-256343-dtfw8o4g 132 6 studies study NNS cord-256343-dtfw8o4g 132 7 on on IN cord-256343-dtfw8o4g 132 8 NSP2 NSP2 NNP cord-256343-dtfw8o4g 132 9 evolution evolution NN cord-256343-dtfw8o4g 132 10 , , , cord-256343-dtfw8o4g 132 11 it -PRON- PRP cord-256343-dtfw8o4g 132 12 can can MD cord-256343-dtfw8o4g 132 13 be be VB cord-256343-dtfw8o4g 132 14 speculated speculate VBN cord-256343-dtfw8o4g 132 15 that that IN cord-256343-dtfw8o4g 132 16 a a DT cord-256343-dtfw8o4g 132 17 less less RBR cord-256343-dtfw8o4g 132 18 biased biased JJ cord-256343-dtfw8o4g 132 19 codon codon NN cord-256343-dtfw8o4g 132 20 usage usage NN cord-256343-dtfw8o4g 132 21 for for IN cord-256343-dtfw8o4g 132 22 a a DT cord-256343-dtfw8o4g 132 23 protein protein NN cord-256343-dtfw8o4g 132 24 involved involve VBN cord-256343-dtfw8o4g 132 25 in in IN cord-256343-dtfw8o4g 132 26 early early JJ cord-256343-dtfw8o4g 132 27 stages stage NNS cord-256343-dtfw8o4g 132 28 of of IN cord-256343-dtfw8o4g 132 29 viral viral JJ cord-256343-dtfw8o4g 132 30 replication replication NN cord-256343-dtfw8o4g 132 31 would would MD cord-256343-dtfw8o4g 132 32 allow allow VB cord-256343-dtfw8o4g 132 33 for for IN cord-256343-dtfw8o4g 132 34 a a DT cord-256343-dtfw8o4g 132 35 less less RBR cord-256343-dtfw8o4g 132 36 restricted restricted JJ cord-256343-dtfw8o4g 132 37 tRNA trna NN cord-256343-dtfw8o4g 132 38 preference preference NN cord-256343-dtfw8o4g 132 39 and and CC cord-256343-dtfw8o4g 132 40 thus thus RB cord-256343-dtfw8o4g 132 41 a a DT cord-256343-dtfw8o4g 132 42 more more RBR cord-256343-dtfw8o4g 132 43 efficient efficient JJ cord-256343-dtfw8o4g 132 44 start start NN cord-256343-dtfw8o4g 132 45 to to IN cord-256343-dtfw8o4g 132 46 the the DT cord-256343-dtfw8o4g 132 47 viral viral JJ cord-256343-dtfw8o4g 132 48 cycle cycle NN cord-256343-dtfw8o4g 132 49 . . . cord-256343-dtfw8o4g 133 1 The the DT cord-256343-dtfw8o4g 133 2 finding finding NN cord-256343-dtfw8o4g 133 3 that that IN cord-256343-dtfw8o4g 133 4 the the DT cord-256343-dtfw8o4g 133 5 most most RBS cord-256343-dtfw8o4g 133 6 biased biased JJ cord-256343-dtfw8o4g 133 7 gene gene NN cord-256343-dtfw8o4g 133 8 was be VBD cord-256343-dtfw8o4g 133 9 S S NNP cord-256343-dtfw8o4g 133 10 ( ( -LRB- cord-256343-dtfw8o4g 133 11 mean mean VB cord-256343-dtfw8o4g 133 12 Nc Nc NNP cord-256343-dtfw8o4g 133 13 = = SYM cord-256343-dtfw8o4g 133 14 43 43 CD cord-256343-dtfw8o4g 133 15 ) ) -RRB- cord-256343-dtfw8o4g 133 16 might may MD cord-256343-dtfw8o4g 133 17 be be VB cord-256343-dtfw8o4g 133 18 linked link VBN cord-256343-dtfw8o4g 133 19 to to IN cord-256343-dtfw8o4g 133 20 its -PRON- PRP$ cord-256343-dtfw8o4g 133 21 relationship relationship NN cord-256343-dtfw8o4g 133 22 with with IN cord-256343-dtfw8o4g 133 23 the the DT cord-256343-dtfw8o4g 133 24 G. G. NNP cord-256343-dtfw8o4g 133 25 gallus gallus NN cord-256343-dtfw8o4g 133 26 immune immune NN cord-256343-dtfw8o4g 133 27 system system NN cord-256343-dtfw8o4g 133 28 . . . cord-256343-dtfw8o4g 134 1 The the DT cord-256343-dtfw8o4g 134 2 spike spike NN cord-256343-dtfw8o4g 134 3 protein protein NN cord-256343-dtfw8o4g 134 4 is be VBZ cord-256343-dtfw8o4g 134 5 the the DT cord-256343-dtfw8o4g 134 6 main main JJ cord-256343-dtfw8o4g 134 7 target target NN cord-256343-dtfw8o4g 134 8 for for IN cord-256343-dtfw8o4g 134 9 neutralizing neutralize VBG cord-256343-dtfw8o4g 134 10 antibodies antibody NNS cord-256343-dtfw8o4g 134 11 , , , cord-256343-dtfw8o4g 134 12 and and CC cord-256343-dtfw8o4g 134 13 thus thus RB cord-256343-dtfw8o4g 134 14 , , , cord-256343-dtfw8o4g 134 15 theoretically theoretically RB cord-256343-dtfw8o4g 134 16 , , , cord-256343-dtfw8o4g 134 17 the the DT cord-256343-dtfw8o4g 134 18 more more JJR cord-256343-dtfw8o4g 134 19 S s NN cord-256343-dtfw8o4g 134 20 protein protein NN cord-256343-dtfw8o4g 134 21 that that WDT cord-256343-dtfw8o4g 134 22 is be VBZ cord-256343-dtfw8o4g 134 23 expressed express VBN cord-256343-dtfw8o4g 134 24 , , , cord-256343-dtfw8o4g 134 25 the the DT cord-256343-dtfw8o4g 134 26 higher high JJR cord-256343-dtfw8o4g 134 27 the the DT cord-256343-dtfw8o4g 134 28 generation generation NN cord-256343-dtfw8o4g 134 29 of of IN cord-256343-dtfw8o4g 134 30 a a DT cord-256343-dtfw8o4g 134 31 humoral humoral JJ cord-256343-dtfw8o4g 134 32 immune immune JJ cord-256343-dtfw8o4g 134 33 response response NN cord-256343-dtfw8o4g 134 34 against against IN cord-256343-dtfw8o4g 134 35 S S NNP cord-256343-dtfw8o4g 134 36 and and CC cord-256343-dtfw8o4g 134 37 the the DT cord-256343-dtfw8o4g 134 38 lower low JJR cord-256343-dtfw8o4g 134 39 cell cell NN cord-256343-dtfw8o4g 134 40 infection infection NN cord-256343-dtfw8o4g 134 41 by by IN cord-256343-dtfw8o4g 134 42 A. a. NN cord-256343-dtfw8o4g 134 43 coronavirus coronavirus NN cord-256343-dtfw8o4g 134 44 . . . cord-256343-dtfw8o4g 135 1 Considering consider VBG cord-256343-dtfw8o4g 135 2 this this DT cord-256343-dtfw8o4g 135 3 stronger strong JJR cord-256343-dtfw8o4g 135 4 codon codon NN cord-256343-dtfw8o4g 135 5 bias bias NN cord-256343-dtfw8o4g 135 6 of of IN cord-256343-dtfw8o4g 135 7 S S NNP cord-256343-dtfw8o4g 135 8 , , , cord-256343-dtfw8o4g 135 9 the the DT cord-256343-dtfw8o4g 135 10 fact fact NN cord-256343-dtfw8o4g 135 11 that that IN cord-256343-dtfw8o4g 135 12 S S NNP cord-256343-dtfw8o4g 135 13 showed show VBD cord-256343-dtfw8o4g 135 14 the the DT cord-256343-dtfw8o4g 135 15 lowest low JJS cord-256343-dtfw8o4g 135 16 CAI CAI NNP cord-256343-dtfw8o4g 135 17 value value NN cord-256343-dtfw8o4g 135 18 when when WRB cord-256343-dtfw8o4g 135 19 compared compare VBN cord-256343-dtfw8o4g 135 20 to to IN cord-256343-dtfw8o4g 135 21 the the DT cord-256343-dtfw8o4g 135 22 other other JJ cord-256343-dtfw8o4g 135 23 three three CD cord-256343-dtfw8o4g 135 24 genes gene NNS cord-256343-dtfw8o4g 135 25 and and CC cord-256343-dtfw8o4g 135 26 the the DT cord-256343-dtfw8o4g 135 27 fact fact NN cord-256343-dtfw8o4g 135 28 that that IN cord-256343-dtfw8o4g 135 29 genes gene NNS cord-256343-dtfw8o4g 135 30 with with IN cord-256343-dtfw8o4g 135 31 lower low JJR cord-256343-dtfw8o4g 135 32 CAIs cai NNS cord-256343-dtfw8o4g 135 33 are be VBP cord-256343-dtfw8o4g 135 34 expressed express VBN cord-256343-dtfw8o4g 135 35 less less RBR cord-256343-dtfw8o4g 135 36 efficiently efficiently RB cord-256343-dtfw8o4g 135 37 ( ( -LRB- cord-256343-dtfw8o4g 135 38 Roth Roth NNP cord-256343-dtfw8o4g 135 39 et et FW cord-256343-dtfw8o4g 135 40 al al NNP cord-256343-dtfw8o4g 135 41 . . NNP cord-256343-dtfw8o4g 135 42 , , , cord-256343-dtfw8o4g 135 43 2012 2012 CD cord-256343-dtfw8o4g 135 44 ) ) -RRB- cord-256343-dtfw8o4g 135 45 , , , cord-256343-dtfw8o4g 135 46 a a DT cord-256343-dtfw8o4g 135 47 deoptimization deoptimization NN cord-256343-dtfw8o4g 135 48 of of IN cord-256343-dtfw8o4g 135 49 S S NNP cord-256343-dtfw8o4g 135 50 expression expression NN cord-256343-dtfw8o4g 135 51 could could MD cord-256343-dtfw8o4g 135 52 have have VB cord-256343-dtfw8o4g 135 53 been be VBN cord-256343-dtfw8o4g 135 54 selected select VBN cord-256343-dtfw8o4g 135 55 for for IN cord-256343-dtfw8o4g 135 56 with with IN cord-256343-dtfw8o4g 135 57 the the DT cord-256343-dtfw8o4g 135 58 advantage advantage NN cord-256343-dtfw8o4g 135 59 of of IN cord-256343-dtfw8o4g 135 60 lower low JJR cord-256343-dtfw8o4g 135 61 S S NNP cord-256343-dtfw8o4g 135 62 expression expression NN cord-256343-dtfw8o4g 135 63 , , , cord-256343-dtfw8o4g 135 64 providing provide VBG cord-256343-dtfw8o4g 135 65 further further JJ cord-256343-dtfw8o4g 135 66 evidence evidence NN cord-256343-dtfw8o4g 135 67 that that IN cord-256343-dtfw8o4g 135 68 viral viral JJ cord-256343-dtfw8o4g 135 69 proteins protein NNS cord-256343-dtfw8o4g 135 70 that that WDT cord-256343-dtfw8o4g 135 71 participate participate VBP cord-256343-dtfw8o4g 135 72 in in IN cord-256343-dtfw8o4g 135 73 host host NN cord-256343-dtfw8o4g 135 74 recognition recognition NN cord-256343-dtfw8o4g 135 75 might may MD cord-256343-dtfw8o4g 135 76 have have VB cord-256343-dtfw8o4g 135 77 a a DT cord-256343-dtfw8o4g 135 78 codon codon NN cord-256343-dtfw8o4g 135 79 usage usage NN cord-256343-dtfw8o4g 135 80 less less RBR cord-256343-dtfw8o4g 135 81 similar similar JJ cord-256343-dtfw8o4g 135 82 to to IN cord-256343-dtfw8o4g 135 83 that that DT cord-256343-dtfw8o4g 135 84 presented present VBN cord-256343-dtfw8o4g 135 85 by by IN cord-256343-dtfw8o4g 135 86 the the DT cord-256343-dtfw8o4g 135 87 host host NN cord-256343-dtfw8o4g 135 88 ( ( -LRB- cord-256343-dtfw8o4g 135 89 Bahir Bahir NNP cord-256343-dtfw8o4g 135 90 et et NNP cord-256343-dtfw8o4g 135 91 al al NNP cord-256343-dtfw8o4g 135 92 . . NNP cord-256343-dtfw8o4g 135 93 , , , cord-256343-dtfw8o4g 135 94 2009 2009 CD cord-256343-dtfw8o4g 135 95 ) ) -RRB- cord-256343-dtfw8o4g 135 96 . . . cord-256343-dtfw8o4g 136 1 Regarding regard VBG cord-256343-dtfw8o4g 136 2 CAI CAI NNP cord-256343-dtfw8o4g 136 3 values value NNS cord-256343-dtfw8o4g 136 4 for for IN cord-256343-dtfw8o4g 136 5 N n CD cord-256343-dtfw8o4g 136 6 , , , cord-256343-dtfw8o4g 136 7 NSP2 NSP2 NNP cord-256343-dtfw8o4g 136 8 and and CC cord-256343-dtfw8o4g 136 9 PL PL NNP cord-256343-dtfw8o4g 136 10 pro pro NN cord-256343-dtfw8o4g 136 11 , , , cord-256343-dtfw8o4g 137 1 Fig Fig NNP cord-256343-dtfw8o4g 137 2 . . . cord-256343-dtfw8o4g 138 1 3 3 LS cord-256343-dtfw8o4g 138 2 suggests suggest VBZ cord-256343-dtfw8o4g 138 3 that that IN cord-256343-dtfw8o4g 138 4 the the DT cord-256343-dtfw8o4g 138 5 distributions distribution NNS cord-256343-dtfw8o4g 138 6 were be VBD cord-256343-dtfw8o4g 138 7 mostly mostly RB cord-256343-dtfw8o4g 138 8 above above IN cord-256343-dtfw8o4g 138 9 those those DT cord-256343-dtfw8o4g 138 10 for for IN cord-256343-dtfw8o4g 138 11 S S NNP cord-256343-dtfw8o4g 138 12 , , , cord-256343-dtfw8o4g 138 13 with with IN cord-256343-dtfw8o4g 138 14 the the DT cord-256343-dtfw8o4g 138 15 highest high JJS cord-256343-dtfw8o4g 138 16 values value NNS cord-256343-dtfw8o4g 138 17 for for IN cord-256343-dtfw8o4g 138 18 N n NN cord-256343-dtfw8o4g 138 19 ( ( -LRB- cord-256343-dtfw8o4g 138 20 0.75 0.75 CD cord-256343-dtfw8o4g 138 21 - - SYM cord-256343-dtfw8o4g 138 22 0.79 0.79 CD cord-256343-dtfw8o4g 138 23 ) ) -RRB- cord-256343-dtfw8o4g 138 24 . . . cord-256343-dtfw8o4g 139 1 N N NNP cord-256343-dtfw8o4g 139 2 protein protein NN cord-256343-dtfw8o4g 139 3 plays play VBZ cord-256343-dtfw8o4g 139 4 a a DT cord-256343-dtfw8o4g 139 5 chief chief JJ cord-256343-dtfw8o4g 139 6 role role NN cord-256343-dtfw8o4g 139 7 in in IN cord-256343-dtfw8o4g 139 8 nucleocapsid nucleocapsid NNP cord-256343-dtfw8o4g 139 9 assembly assembly NNP cord-256343-dtfw8o4g 139 10 that that WDT cord-256343-dtfw8o4g 139 11 is be VBZ cord-256343-dtfw8o4g 139 12 dependent dependent JJ cord-256343-dtfw8o4g 139 13 on on IN cord-256343-dtfw8o4g 139 14 the the DT cord-256343-dtfw8o4g 139 15 association association NN cord-256343-dtfw8o4g 139 16 of of IN cord-256343-dtfw8o4g 139 17 positively positively RB cord-256343-dtfw8o4g 139 18 charged charge VBN cord-256343-dtfw8o4g 139 19 amino amino NN cord-256343-dtfw8o4g 139 20 acids acid NNS cord-256343-dtfw8o4g 139 21 with with IN cord-256343-dtfw8o4g 139 22 the the DT cord-256343-dtfw8o4g 139 23 genomic genomic JJ cord-256343-dtfw8o4g 139 24 RNA RNA NNP cord-256343-dtfw8o4g 139 25 of of IN cord-256343-dtfw8o4g 139 26 coronaviruses coronaviruse NNS cord-256343-dtfw8o4g 139 27 ( ( -LRB- cord-256343-dtfw8o4g 139 28 Masters Masters NNPS cord-256343-dtfw8o4g 139 29 , , , cord-256343-dtfw8o4g 139 30 2006 2006 CD cord-256343-dtfw8o4g 139 31 ) ) -RRB- cord-256343-dtfw8o4g 139 32 and and CC cord-256343-dtfw8o4g 139 33 is be VBZ cord-256343-dtfw8o4g 139 34 thus thus RB cord-256343-dtfw8o4g 139 35 under under IN cord-256343-dtfw8o4g 139 36 strong strong JJ cord-256343-dtfw8o4g 139 37 purifying purifying NN cord-256343-dtfw8o4g 139 38 selection selection NN cord-256343-dtfw8o4g 139 39 , , , cord-256343-dtfw8o4g 139 40 as as IN cord-256343-dtfw8o4g 139 41 shown show VBN cord-256343-dtfw8o4g 139 42 herein herein RB cord-256343-dtfw8o4g 139 43 by by IN cord-256343-dtfw8o4g 139 44 the the DT cord-256343-dtfw8o4g 139 45 Fisher Fisher NNP cord-256343-dtfw8o4g 139 46 's 's POS cord-256343-dtfw8o4g 139 47 exact exact JJ cord-256343-dtfw8o4g 139 48 test test NN cord-256343-dtfw8o4g 139 49 on on IN cord-256343-dtfw8o4g 139 50 dS dS NNP cord-256343-dtfw8o4g 139 51 - - HYPH cord-256343-dtfw8o4g 139 52 dN dN NNP cord-256343-dtfw8o4g 139 53 values value NNS cord-256343-dtfw8o4g 139 54 . . . cord-256343-dtfw8o4g 140 1 Optimization optimization NN cord-256343-dtfw8o4g 140 2 of of IN cord-256343-dtfw8o4g 140 3 the the DT cord-256343-dtfw8o4g 140 4 codon codon NN cord-256343-dtfw8o4g 140 5 usage usage NN cord-256343-dtfw8o4g 140 6 in in IN cord-256343-dtfw8o4g 140 7 a a DT cord-256343-dtfw8o4g 140 8 manner manner NN cord-256343-dtfw8o4g 140 9 closer close RBR cord-256343-dtfw8o4g 140 10 to to IN cord-256343-dtfw8o4g 140 11 that that DT cord-256343-dtfw8o4g 140 12 of of IN cord-256343-dtfw8o4g 140 13 the the DT cord-256343-dtfw8o4g 140 14 host host NN cord-256343-dtfw8o4g 140 15 would would MD cord-256343-dtfw8o4g 140 16 endow endow VB cord-256343-dtfw8o4g 140 17 A. a. NN cord-256343-dtfw8o4g 140 18 coronavirus coronavirus NN cord-256343-dtfw8o4g 140 19 with with IN cord-256343-dtfw8o4g 140 20 a a DT cord-256343-dtfw8o4g 140 21 more more RBR cord-256343-dtfw8o4g 140 22 efficient efficient JJ cord-256343-dtfw8o4g 140 23 and and CC cord-256343-dtfw8o4g 140 24 accurate accurate JJ cord-256343-dtfw8o4g 140 25 synthesis synthesis NN cord-256343-dtfw8o4g 140 26 of of IN cord-256343-dtfw8o4g 140 27 the the DT cord-256343-dtfw8o4g 140 28 nucleocapsid nucleocapsid NNP cord-256343-dtfw8o4g 140 29 protein protein NN cord-256343-dtfw8o4g 140 30 . . . cord-256343-dtfw8o4g 141 1 The the DT cord-256343-dtfw8o4g 141 2 distribution distribution NN cord-256343-dtfw8o4g 141 3 of of IN cord-256343-dtfw8o4g 141 4 CAIs CAIs NNPS cord-256343-dtfw8o4g 141 5 for for IN cord-256343-dtfw8o4g 141 6 NSP2 NSP2 NNP cord-256343-dtfw8o4g 141 7 and and CC cord-256343-dtfw8o4g 141 8 PL PL NNP cord-256343-dtfw8o4g 141 9 pro pro NNP cord-256343-dtfw8o4g 141 10 stayed stay VBD cord-256343-dtfw8o4g 141 11 between between IN cord-256343-dtfw8o4g 141 12 those those DT cord-256343-dtfw8o4g 141 13 for for IN cord-256343-dtfw8o4g 141 14 N N NNP cord-256343-dtfw8o4g 141 15 and and CC cord-256343-dtfw8o4g 141 16 S S NNP cord-256343-dtfw8o4g 141 17 ( ( -LRB- cord-256343-dtfw8o4g 141 18 Fig Fig NNP cord-256343-dtfw8o4g 141 19 . . . cord-256343-dtfw8o4g 141 20 3 3 CD cord-256343-dtfw8o4g 141 21 ) ) -RRB- cord-256343-dtfw8o4g 141 22 . . . cord-256343-dtfw8o4g 142 1 Considering consider VBG cord-256343-dtfw8o4g 142 2 that that IN cord-256343-dtfw8o4g 142 3 PL pl NN cord-256343-dtfw8o4g 142 4 pro pro NN cord-256343-dtfw8o4g 142 5 is be VBZ cord-256343-dtfw8o4g 142 6 a a DT cord-256343-dtfw8o4g 142 7 protease protease NN cord-256343-dtfw8o4g 142 8 acting act VBG cord-256343-dtfw8o4g 142 9 on on IN cord-256343-dtfw8o4g 142 10 the the DT cord-256343-dtfw8o4g 142 11 N n CD cord-256343-dtfw8o4g 142 12 - - HYPH cord-256343-dtfw8o4g 142 13 terminus terminus NN cord-256343-dtfw8o4g 142 14 domains domain NNS cord-256343-dtfw8o4g 142 15 of of IN cord-256343-dtfw8o4g 143 1 replicase replicase NNP cord-256343-dtfw8o4g 143 2 polyproteins polyproteins NNP cord-256343-dtfw8o4g 143 3 pp1a pp1a NNP cord-256343-dtfw8o4g 143 4 and and CC cord-256343-dtfw8o4g 143 5 pp1ab pp1ab NNP cord-256343-dtfw8o4g 143 6 ( ( -LRB- cord-256343-dtfw8o4g 143 7 Ziebuhr Ziebuhr NNP cord-256343-dtfw8o4g 143 8 et et NNP cord-256343-dtfw8o4g 143 9 al al NNP cord-256343-dtfw8o4g 143 10 . . NNP cord-256343-dtfw8o4g 143 11 , , , cord-256343-dtfw8o4g 143 12 2000 2000 CD cord-256343-dtfw8o4g 143 13 ) ) -RRB- cord-256343-dtfw8o4g 143 14 , , , cord-256343-dtfw8o4g 143 15 an an DT cord-256343-dtfw8o4g 143 16 intermediate intermediate JJ cord-256343-dtfw8o4g 143 17 adaptation adaptation NN cord-256343-dtfw8o4g 143 18 to to IN cord-256343-dtfw8o4g 143 19 the the DT cord-256343-dtfw8o4g 143 20 host host NN cord-256343-dtfw8o4g 143 21 's 's POS cord-256343-dtfw8o4g 143 22 translational translational JJ cord-256343-dtfw8o4g 143 23 environment environment NN cord-256343-dtfw8o4g 143 24 could could MD cord-256343-dtfw8o4g 143 25 have have VB cord-256343-dtfw8o4g 143 26 evolved evolve VBN cord-256343-dtfw8o4g 143 27 as as IN cord-256343-dtfw8o4g 143 28 a a DT cord-256343-dtfw8o4g 143 29 balance balance NN cord-256343-dtfw8o4g 143 30 between between IN cord-256343-dtfw8o4g 143 31 the the DT cord-256343-dtfw8o4g 143 32 conservation conservation NN cord-256343-dtfw8o4g 143 33 of of IN cord-256343-dtfw8o4g 143 34 structure structure NN cord-256343-dtfw8o4g 143 35 of of IN cord-256343-dtfw8o4g 143 36 the the DT cord-256343-dtfw8o4g 143 37 enzymatic enzymatic JJ cord-256343-dtfw8o4g 143 38 domain domain NN cord-256343-dtfw8o4g 143 39 and and CC cord-256343-dtfw8o4g 143 40 the the DT cord-256343-dtfw8o4g 143 41 plasticity plasticity NN cord-256343-dtfw8o4g 143 42 to to TO cord-256343-dtfw8o4g 143 43 follow follow VB cord-256343-dtfw8o4g 143 44 amino amino NN cord-256343-dtfw8o4g 143 45 acid acid NN cord-256343-dtfw8o4g 143 46 mutations mutation NNS cord-256343-dtfw8o4g 143 47 occurring occur VBG cord-256343-dtfw8o4g 143 48 on on IN cord-256343-dtfw8o4g 143 49 the the DT cord-256343-dtfw8o4g 143 50 PL pl NN cord-256343-dtfw8o4g 143 51 pro pro JJ cord-256343-dtfw8o4g 143 52 cleavage cleavage NN cord-256343-dtfw8o4g 143 53 sites site NNS cord-256343-dtfw8o4g 143 54 of of IN cord-256343-dtfw8o4g 143 55 diverse diverse JJ cord-256343-dtfw8o4g 143 56 A. a. NN cord-256343-dtfw8o4g 143 57 coronavirus coronavirus NN cord-256343-dtfw8o4g 143 58 types type NNS cord-256343-dtfw8o4g 143 59 as as IN cord-256343-dtfw8o4g 143 60 compensatory compensatory JJ cord-256343-dtfw8o4g 143 61 mutations mutation NNS cord-256343-dtfw8o4g 143 62 , , , cord-256343-dtfw8o4g 143 63 showing show VBG cord-256343-dtfw8o4g 143 64 that that IN cord-256343-dtfw8o4g 143 65 epistasis epistasis NN cord-256343-dtfw8o4g 143 66 could could MD cord-256343-dtfw8o4g 143 67 also also RB cord-256343-dtfw8o4g 143 68 be be VB cord-256343-dtfw8o4g 143 69 detected detect VBN cord-256343-dtfw8o4g 143 70 at at IN cord-256343-dtfw8o4g 143 71 the the DT cord-256343-dtfw8o4g 143 72 codon codon NN cord-256343-dtfw8o4g 143 73 usage usage NN cord-256343-dtfw8o4g 143 74 evolution evolution NN cord-256343-dtfw8o4g 143 75 level level NN cord-256343-dtfw8o4g 143 76 . . . cord-256343-dtfw8o4g 144 1 It -PRON- PRP cord-256343-dtfw8o4g 144 2 is be VBZ cord-256343-dtfw8o4g 144 3 noteworthy noteworthy JJ cord-256343-dtfw8o4g 144 4 that that IN cord-256343-dtfw8o4g 144 5 none none NN cord-256343-dtfw8o4g 144 6 of of IN cord-256343-dtfw8o4g 144 7 the the DT cord-256343-dtfw8o4g 144 8 A. a. NN cord-256343-dtfw8o4g 144 9 coronavirus coronavirus NN cord-256343-dtfw8o4g 144 10 strains strain NNS cord-256343-dtfw8o4g 144 11 showed show VBD cord-256343-dtfw8o4g 144 12 no no DT cord-256343-dtfw8o4g 144 13 possible possible JJ cord-256343-dtfw8o4g 144 14 combinations combination NNS cord-256343-dtfw8o4g 144 15 of of IN cord-256343-dtfw8o4g 144 16 simultaneous simultaneous JJ cord-256343-dtfw8o4g 144 17 occurrence occurrence NN cord-256343-dtfw8o4g 144 18 maximum maximum NN cord-256343-dtfw8o4g 144 19 / / SYM cord-256343-dtfw8o4g 144 20 minimum minimum NN cord-256343-dtfw8o4g 144 21 CAI CAI NNP cord-256343-dtfw8o4g 144 22 or or CC cord-256343-dtfw8o4g 144 23 Nc Nc NNP cord-256343-dtfw8o4g 144 24 ( ( -LRB- cord-256343-dtfw8o4g 144 25 data datum NNS cord-256343-dtfw8o4g 144 26 not not RB cord-256343-dtfw8o4g 144 27 shown show VBN cord-256343-dtfw8o4g 144 28 ) ) -RRB- cord-256343-dtfw8o4g 144 29 for for IN cord-256343-dtfw8o4g 144 30 any any DT cord-256343-dtfw8o4g 144 31 of of IN cord-256343-dtfw8o4g 144 32 the the DT cord-256343-dtfw8o4g 144 33 four four CD cord-256343-dtfw8o4g 144 34 genes gene NNS cord-256343-dtfw8o4g 144 35 , , , cord-256343-dtfw8o4g 144 36 meaning mean VBG cord-256343-dtfw8o4g 144 37 that that IN cord-256343-dtfw8o4g 144 38 CAI CAI NNP cord-256343-dtfw8o4g 144 39 and and CC cord-256343-dtfw8o4g 144 40 Nc Nc NNP cord-256343-dtfw8o4g 144 41 might may MD cord-256343-dtfw8o4g 144 42 be be VB cord-256343-dtfw8o4g 144 43 driven drive VBN cord-256343-dtfw8o4g 144 44 to to IN cord-256343-dtfw8o4g 144 45 different different JJ cord-256343-dtfw8o4g 144 46 evolutionary evolutionary JJ cord-256343-dtfw8o4g 144 47 pathways pathway NNS cord-256343-dtfw8o4g 144 48 and and CC cord-256343-dtfw8o4g 144 49 that that IN cord-256343-dtfw8o4g 144 50 strains strain NNS cord-256343-dtfw8o4g 144 51 with with IN cord-256343-dtfw8o4g 144 52 a a DT cord-256343-dtfw8o4g 144 53 high high JJ cord-256343-dtfw8o4g 144 54 CAI cai NN cord-256343-dtfw8o4g 144 55 , , , cord-256343-dtfw8o4g 144 56 i.e. i.e. FW cord-256343-dtfw8o4g 144 57 , , , cord-256343-dtfw8o4g 144 58 highly highly RB cord-256343-dtfw8o4g 144 59 adapted adapt VBN cord-256343-dtfw8o4g 144 60 to to IN cord-256343-dtfw8o4g 144 61 the the DT cord-256343-dtfw8o4g 144 62 host host NN cord-256343-dtfw8o4g 144 63 's 's POS cord-256343-dtfw8o4g 144 64 transcription transcription NN cord-256343-dtfw8o4g 144 65 environment environment NN cord-256343-dtfw8o4g 144 66 , , , cord-256343-dtfw8o4g 144 67 are be VBP cord-256343-dtfw8o4g 144 68 not not RB cord-256343-dtfw8o4g 144 69 necessarily necessarily RB cord-256343-dtfw8o4g 144 70 the the DT cord-256343-dtfw8o4g 144 71 ones one NNS cord-256343-dtfw8o4g 144 72 with with IN cord-256343-dtfw8o4g 144 73 the the DT cord-256343-dtfw8o4g 144 74 lower low JJR cord-256343-dtfw8o4g 144 75 bias bias NN cord-256343-dtfw8o4g 144 76 , , , cord-256343-dtfw8o4g 144 77 i.e. i.e. FW cord-256343-dtfw8o4g 144 78 , , , cord-256343-dtfw8o4g 144 79 with with IN cord-256343-dtfw8o4g 144 80 higher high JJR cord-256343-dtfw8o4g 144 81 Nc Nc NNP cord-256343-dtfw8o4g 144 82 . . . cord-256343-dtfw8o4g 145 1 The the DT cord-256343-dtfw8o4g 145 2 distribution distribution NN cord-256343-dtfw8o4g 145 3 of of IN cord-256343-dtfw8o4g 145 4 100 100 CD cord-256343-dtfw8o4g 145 5 % % NN cord-256343-dtfw8o4g 145 6 conserved conserve VBN cord-256343-dtfw8o4g 145 7 amino amino NN cord-256343-dtfw8o4g 145 8 acid acid NN cord-256343-dtfw8o4g 145 9 positions position NNS cord-256343-dtfw8o4g 145 10 coded code VBN cord-256343-dtfw8o4g 145 11 by by IN cord-256343-dtfw8o4g 145 12 the the DT cord-256343-dtfw8o4g 145 13 preferred preferred JJ cord-256343-dtfw8o4g 145 14 codon codon NN cord-256343-dtfw8o4g 145 15 is be VBZ cord-256343-dtfw8o4g 145 16 noteworthy noteworthy JJ cord-256343-dtfw8o4g 145 17 when when WRB cord-256343-dtfw8o4g 145 18 one one PRP cord-256343-dtfw8o4g 145 19 compares compare VBZ cord-256343-dtfw8o4g 145 20 the the DT cord-256343-dtfw8o4g 145 21 S S NNP cord-256343-dtfw8o4g 145 22 gene gene NN cord-256343-dtfw8o4g 145 23 with with IN cord-256343-dtfw8o4g 145 24 N n CD cord-256343-dtfw8o4g 145 25 , , , cord-256343-dtfw8o4g 145 26 NSP2 NSP2 NNP cord-256343-dtfw8o4g 145 27 or or CC cord-256343-dtfw8o4g 145 28 PL PL NNP cord-256343-dtfw8o4g 145 29 pro pro UH cord-256343-dtfw8o4g 145 30 , , , cord-256343-dtfw8o4g 145 31 as as IN cord-256343-dtfw8o4g 145 32 a a DT cord-256343-dtfw8o4g 145 33 single single JJ cord-256343-dtfw8o4g 145 34 position position NN cord-256343-dtfw8o4g 145 35 was be VBD cord-256343-dtfw8o4g 145 36 found find VBN cord-256343-dtfw8o4g 145 37 in in IN cord-256343-dtfw8o4g 145 38 a a DT cord-256343-dtfw8o4g 145 39 region region NN cord-256343-dtfw8o4g 145 40 outside outside IN cord-256343-dtfw8o4g 145 41 antigenic antigenic JJ cord-256343-dtfw8o4g 145 42 and and CC cord-256343-dtfw8o4g 145 43 hypervariable hypervariable JJ cord-256343-dtfw8o4g 145 44 regions region NNS cord-256343-dtfw8o4g 145 45 ( ( -LRB- cord-256343-dtfw8o4g 145 46 Cavanagh Cavanagh NNP cord-256343-dtfw8o4g 145 47 et et NNP cord-256343-dtfw8o4g 145 48 al al NNP cord-256343-dtfw8o4g 145 49 . . NNP cord-256343-dtfw8o4g 145 50 , , , cord-256343-dtfw8o4g 145 51 1988 1988 CD cord-256343-dtfw8o4g 145 52 ; ; : cord-256343-dtfw8o4g 145 53 Kant Kant NNP cord-256343-dtfw8o4g 145 54 et et NNP cord-256343-dtfw8o4g 145 55 al al NNP cord-256343-dtfw8o4g 145 56 . . NNP cord-256343-dtfw8o4g 145 57 , , , cord-256343-dtfw8o4g 145 58 1992 1992 CD cord-256343-dtfw8o4g 145 59 ) ) -RRB- cord-256343-dtfw8o4g 145 60 in in IN cord-256343-dtfw8o4g 145 61 the the DT cord-256343-dtfw8o4g 145 62 S S NNP cord-256343-dtfw8o4g 145 63 gene gene NN cord-256343-dtfw8o4g 145 64 , , , cord-256343-dtfw8o4g 145 65 while while IN cord-256343-dtfw8o4g 145 66 for for IN cord-256343-dtfw8o4g 145 67 the the DT cord-256343-dtfw8o4g 145 68 other other JJ cord-256343-dtfw8o4g 145 69 three three CD cord-256343-dtfw8o4g 145 70 genes gene NNS cord-256343-dtfw8o4g 145 71 , , , cord-256343-dtfw8o4g 145 72 these these DT cord-256343-dtfw8o4g 145 73 positions position NNS cord-256343-dtfw8o4g 145 74 ( ( -LRB- cord-256343-dtfw8o4g 145 75 n n NN cord-256343-dtfw8o4g 145 76 = = SYM cord-256343-dtfw8o4g 145 77 20 20 CD cord-256343-dtfw8o4g 145 78 , , , cord-256343-dtfw8o4g 145 79 28 28 CD cord-256343-dtfw8o4g 145 80 and and CC cord-256343-dtfw8o4g 145 81 71 71 CD cord-256343-dtfw8o4g 145 82 , , , cord-256343-dtfw8o4g 145 83 respectively respectively RB cord-256343-dtfw8o4g 145 84 ) ) -RRB- cord-256343-dtfw8o4g 145 85 were be VBD cord-256343-dtfw8o4g 145 86 scattered scatter VBN cord-256343-dtfw8o4g 145 87 throughout throughout IN cord-256343-dtfw8o4g 145 88 the the DT cord-256343-dtfw8o4g 145 89 regions region NNS cord-256343-dtfw8o4g 145 90 considered consider VBN cord-256343-dtfw8o4g 145 91 , , , cord-256343-dtfw8o4g 145 92 with with IN cord-256343-dtfw8o4g 145 93 statistically statistically RB cord-256343-dtfw8o4g 145 94 significant significant JJ cord-256343-dtfw8o4g 145 95 differences difference NNS cord-256343-dtfw8o4g 145 96 when when WRB cord-256343-dtfw8o4g 145 97 compared compare VBN cord-256343-dtfw8o4g 145 98 to to IN cord-256343-dtfw8o4g 145 99 S s NN cord-256343-dtfw8o4g 145 100 ( ( -LRB- cord-256343-dtfw8o4g 145 101 p p NN cord-256343-dtfw8o4g 145 102 < < XX cord-256343-dtfw8o4g 145 103 0.0001 0.0001 CD cord-256343-dtfw8o4g 145 104 , , , cord-256343-dtfw8o4g 145 105 OR or CC cord-256343-dtfw8o4g 145 106 = = SYM cord-256343-dtfw8o4g 145 107 21.7 21.7 CD cord-256343-dtfw8o4g 145 108 - - HYPH cord-256343-dtfw8o4g 145 109 37.8 37.8 CD cord-256343-dtfw8o4g 145 110 ) ) -RRB- cord-256343-dtfw8o4g 145 111 . . . cord-256343-dtfw8o4g 146 1 This this DT cord-256343-dtfw8o4g 146 2 low low JJ cord-256343-dtfw8o4g 146 3 number number NN cord-256343-dtfw8o4g 146 4 of of IN cord-256343-dtfw8o4g 146 5 conserved conserve VBN cord-256343-dtfw8o4g 146 6 amino amino NN cord-256343-dtfw8o4g 146 7 acid acid NN cord-256343-dtfw8o4g 146 8 positions position NNS cord-256343-dtfw8o4g 146 9 coded code VBN cord-256343-dtfw8o4g 146 10 by by IN cord-256343-dtfw8o4g 146 11 the the DT cord-256343-dtfw8o4g 146 12 preferred preferred JJ cord-256343-dtfw8o4g 146 13 codon codon NN cord-256343-dtfw8o4g 146 14 in in IN cord-256343-dtfw8o4g 146 15 S S NNP cord-256343-dtfw8o4g 146 16 could could MD cord-256343-dtfw8o4g 146 17 be be VB cord-256343-dtfw8o4g 146 18 an an DT cord-256343-dtfw8o4g 146 19 additional additional JJ cord-256343-dtfw8o4g 146 20 molecular molecular JJ cord-256343-dtfw8o4g 146 21 evolutionary evolutionary JJ cord-256343-dtfw8o4g 146 22 mechanism mechanism NN cord-256343-dtfw8o4g 146 23 for for IN cord-256343-dtfw8o4g 146 24 S s NN cord-256343-dtfw8o4g 146 25 antigenic antigenic JJ cord-256343-dtfw8o4g 146 26 diversity diversity NN cord-256343-dtfw8o4g 146 27 , , , cord-256343-dtfw8o4g 146 28 as as IN cord-256343-dtfw8o4g 146 29 fine fine JJ cord-256343-dtfw8o4g 146 30 - - HYPH cord-256343-dtfw8o4g 146 31 tuning tuning NN cord-256343-dtfw8o4g 146 32 translation translation NN cord-256343-dtfw8o4g 146 33 kinetics kinetics NN cord-256343-dtfw8o4g 146 34 could could MD cord-256343-dtfw8o4g 146 35 result result VB cord-256343-dtfw8o4g 146 36 in in IN cord-256343-dtfw8o4g 146 37 high high JJ cord-256343-dtfw8o4g 146 38 deoptimization deoptimization NN cord-256343-dtfw8o4g 146 39 of of IN cord-256343-dtfw8o4g 146 40 codon codon NN cord-256343-dtfw8o4g 146 41 usage usage NN cord-256343-dtfw8o4g 146 42 and and CC cord-256343-dtfw8o4g 146 43 a a DT cord-256343-dtfw8o4g 146 44 consequent consequent JJ cord-256343-dtfw8o4g 146 45 increased increase VBN cord-256343-dtfw8o4g 146 46 fitness fitness NN cord-256343-dtfw8o4g 146 47 ( ( -LRB- cord-256343-dtfw8o4g 146 48 Aragonés Aragonés NNP cord-256343-dtfw8o4g 146 49 et et NNP cord-256343-dtfw8o4g 146 50 al al NNP cord-256343-dtfw8o4g 146 51 . . NNP cord-256343-dtfw8o4g 146 52 , , , cord-256343-dtfw8o4g 146 53 2010 2010 CD cord-256343-dtfw8o4g 146 54 ) ) -RRB- cord-256343-dtfw8o4g 146 55 . . . cord-256343-dtfw8o4g 147 1 On on IN cord-256343-dtfw8o4g 147 2 the the DT cord-256343-dtfw8o4g 147 3 other other JJ cord-256343-dtfw8o4g 147 4 hand hand NN cord-256343-dtfw8o4g 147 5 , , , cord-256343-dtfw8o4g 147 6 possibly possibly RB cord-256343-dtfw8o4g 147 7 due due JJ cord-256343-dtfw8o4g 147 8 to to IN cord-256343-dtfw8o4g 147 9 strong strong JJ cord-256343-dtfw8o4g 147 10 structural structural JJ cord-256343-dtfw8o4g 147 11 and and CC cord-256343-dtfw8o4g 147 12 functional functional JJ cord-256343-dtfw8o4g 147 13 constraints constraint NNS cord-256343-dtfw8o4g 147 14 , , , cord-256343-dtfw8o4g 147 15 N n CD cord-256343-dtfw8o4g 147 16 , , , cord-256343-dtfw8o4g 147 17 NSP2 NSP2 NNP cord-256343-dtfw8o4g 147 18 and and CC cord-256343-dtfw8o4g 147 19 PL PL NNP cord-256343-dtfw8o4g 147 20 pro pro FW cord-256343-dtfw8o4g 147 21 have have VBP cord-256343-dtfw8o4g 147 22 a a DT cord-256343-dtfw8o4g 147 23 higher high JJR cord-256343-dtfw8o4g 147 24 number number NN cord-256343-dtfw8o4g 147 25 of of IN cord-256343-dtfw8o4g 147 26 amino amino NN cord-256343-dtfw8o4g 147 27 acid acid NN cord-256343-dtfw8o4g 147 28 positions position NNS cord-256343-dtfw8o4g 147 29 coded code VBN cord-256343-dtfw8o4g 147 30 by by IN cord-256343-dtfw8o4g 147 31 the the DT cord-256343-dtfw8o4g 147 32 preferred preferred JJ cord-256343-dtfw8o4g 147 33 codon codon NN cord-256343-dtfw8o4g 147 34 , , , cord-256343-dtfw8o4g 147 35 which which WDT cord-256343-dtfw8o4g 147 36 is be VBZ cord-256343-dtfw8o4g 147 37 the the DT cord-256343-dtfw8o4g 147 38 same same JJ cord-256343-dtfw8o4g 147 39 codon codon NN cord-256343-dtfw8o4g 147 40 preferred prefer VBN cord-256343-dtfw8o4g 147 41 by by IN cord-256343-dtfw8o4g 147 42 the the DT cord-256343-dtfw8o4g 147 43 host host NN cord-256343-dtfw8o4g 147 44 ( ( -LRB- cord-256343-dtfw8o4g 147 45 Table table NN cord-256343-dtfw8o4g 147 46 1 1 CD cord-256343-dtfw8o4g 147 47 ) ) -RRB- cord-256343-dtfw8o4g 147 48 , , , cord-256343-dtfw8o4g 147 49 which which WDT cord-256343-dtfw8o4g 147 50 would would MD cord-256343-dtfw8o4g 147 51 allow allow VB cord-256343-dtfw8o4g 147 52 higher high JJR cord-256343-dtfw8o4g 147 53 fitness fitness NN cord-256343-dtfw8o4g 147 54 to to IN cord-256343-dtfw8o4g 147 55 the the DT cord-256343-dtfw8o4g 147 56 host host NN cord-256343-dtfw8o4g 147 57 transcription transcription NN cord-256343-dtfw8o4g 147 58 environment environment NN cord-256343-dtfw8o4g 148 1 ( ( -LRB- cord-256343-dtfw8o4g 148 2 Zhou Zhou NNP cord-256343-dtfw8o4g 148 3 et et NNP cord-256343-dtfw8o4g 148 4 al al NNP cord-256343-dtfw8o4g 148 5 . . NNP cord-256343-dtfw8o4g 148 6 , , , cord-256343-dtfw8o4g 148 7 2012 2012 CD cord-256343-dtfw8o4g 148 8 ) ) -RRB- cord-256343-dtfw8o4g 148 9 in in IN cord-256343-dtfw8o4g 148 10 a a DT cord-256343-dtfw8o4g 148 11 concerted concerted JJ cord-256343-dtfw8o4g 148 12 virus virus NN cord-256343-dtfw8o4g 148 13 - - HYPH cord-256343-dtfw8o4g 148 14 host host NN cord-256343-dtfw8o4g 148 15 molecular molecular JJ cord-256343-dtfw8o4g 148 16 evolution evolution NN cord-256343-dtfw8o4g 148 17 . . . cord-256343-dtfw8o4g 149 1 Thus thus RB cord-256343-dtfw8o4g 149 2 , , , cord-256343-dtfw8o4g 149 3 taking take VBG cord-256343-dtfw8o4g 149 4 conserved conserve VBN cord-256343-dtfw8o4g 149 5 amino amino NN cord-256343-dtfw8o4g 149 6 acid acid NN cord-256343-dtfw8o4g 149 7 positions position NNS cord-256343-dtfw8o4g 149 8 coded code VBN cord-256343-dtfw8o4g 149 9 by by IN cord-256343-dtfw8o4g 149 10 the the DT cord-256343-dtfw8o4g 149 11 preferred preferred JJ cord-256343-dtfw8o4g 149 12 codons codon NNS cord-256343-dtfw8o4g 149 13 as as IN cord-256343-dtfw8o4g 149 14 a a DT cord-256343-dtfw8o4g 149 15 selection selection NN cord-256343-dtfw8o4g 149 16 unit unit NN cord-256343-dtfw8o4g 149 17 , , , cord-256343-dtfw8o4g 149 18 it -PRON- PRP cord-256343-dtfw8o4g 149 19 follows follow VBZ cord-256343-dtfw8o4g 149 20 from from IN cord-256343-dtfw8o4g 149 21 the the DT cord-256343-dtfw8o4g 149 22 above above RB cord-256343-dtfw8o4g 149 23 mentioned mention VBN cord-256343-dtfw8o4g 149 24 differences difference NNS cord-256343-dtfw8o4g 149 25 that that IN cord-256343-dtfw8o4g 149 26 natural natural JJ cord-256343-dtfw8o4g 149 27 selection selection NN cord-256343-dtfw8o4g 149 28 could could MD cord-256343-dtfw8o4g 149 29 either either CC cord-256343-dtfw8o4g 149 30 be be VB cord-256343-dtfw8o4g 149 31 positive positive JJ cord-256343-dtfw8o4g 149 32 for for IN cord-256343-dtfw8o4g 149 33 these these DT cord-256343-dtfw8o4g 149 34 positions position NNS cord-256343-dtfw8o4g 149 35 , , , cord-256343-dtfw8o4g 149 36 leading lead VBG cord-256343-dtfw8o4g 149 37 a a DT cord-256343-dtfw8o4g 149 38 protein protein NN cord-256343-dtfw8o4g 149 39 under under IN cord-256343-dtfw8o4g 149 40 purifying purify VBG cord-256343-dtfw8o4g 149 41 selection selection NN cord-256343-dtfw8o4g 149 42 ( ( -LRB- cord-256343-dtfw8o4g 149 43 e.g. e.g. RB cord-256343-dtfw8o4g 149 44 , , , cord-256343-dtfw8o4g 149 45 N n CD cord-256343-dtfw8o4g 149 46 , , , cord-256343-dtfw8o4g 149 47 NSP2 NSP2 NNP cord-256343-dtfw8o4g 149 48 and and CC cord-256343-dtfw8o4g 149 49 PL PL NNP cord-256343-dtfw8o4g 149 50 pro pro NN cord-256343-dtfw8o4g 149 51 ) ) -RRB- cord-256343-dtfw8o4g 149 52 to to TO cord-256343-dtfw8o4g 149 53 show show VB cord-256343-dtfw8o4g 149 54 the the DT cord-256343-dtfw8o4g 149 55 same same JJ cord-256343-dtfw8o4g 149 56 codons codon NNS cord-256343-dtfw8o4g 149 57 as as IN cord-256343-dtfw8o4g 149 58 the the DT cord-256343-dtfw8o4g 149 59 host host NN cord-256343-dtfw8o4g 149 60 for for IN cord-256343-dtfw8o4g 149 61 that that DT cord-256343-dtfw8o4g 149 62 amino amino NN cord-256343-dtfw8o4g 149 63 acid acid NN cord-256343-dtfw8o4g 149 64 , , , cord-256343-dtfw8o4g 149 65 or or CC cord-256343-dtfw8o4g 149 66 negative negative JJ cord-256343-dtfw8o4g 149 67 if if IN cord-256343-dtfw8o4g 149 68 a a DT cord-256343-dtfw8o4g 149 69 protein protein NN cord-256343-dtfw8o4g 149 70 is be VBZ cord-256343-dtfw8o4g 149 71 under under IN cord-256343-dtfw8o4g 149 72 positive positive JJ cord-256343-dtfw8o4g 149 73 selection selection NN cord-256343-dtfw8o4g 149 74 ( ( -LRB- cord-256343-dtfw8o4g 149 75 as as IN cord-256343-dtfw8o4g 149 76 shown show VBN cord-256343-dtfw8o4g 149 77 for for IN cord-256343-dtfw8o4g 149 78 S S NNP cord-256343-dtfw8o4g 149 79 ) ) -RRB- cord-256343-dtfw8o4g 149 80 . . . cord-256343-dtfw8o4g 150 1 The the DT cord-256343-dtfw8o4g 150 2 most most RBS cord-256343-dtfw8o4g 150 3 probable probable JJ cord-256343-dtfw8o4g 150 4 reason reason NN cord-256343-dtfw8o4g 150 5 for for IN cord-256343-dtfw8o4g 150 6 the the DT cord-256343-dtfw8o4g 150 7 fact fact NN cord-256343-dtfw8o4g 150 8 that that IN cord-256343-dtfw8o4g 150 9 non-100 non-100 NNP cord-256343-dtfw8o4g 150 10 % % NN cord-256343-dtfw8o4g 150 11 conserved conserve VBN cord-256343-dtfw8o4g 150 12 amino amino NN cord-256343-dtfw8o4g 150 13 acid acid NN cord-256343-dtfw8o4g 150 14 positions position NNS cord-256343-dtfw8o4g 150 15 coded code VBN cord-256343-dtfw8o4g 150 16 by by IN cord-256343-dtfw8o4g 150 17 a a DT cord-256343-dtfw8o4g 150 18 preferred preferred JJ cord-256343-dtfw8o4g 150 19 codon codon NN cord-256343-dtfw8o4g 150 20 for for IN cord-256343-dtfw8o4g 150 21 that that DT cord-256343-dtfw8o4g 150 22 amino amino NN cord-256343-dtfw8o4g 150 23 acid acid NN cord-256343-dtfw8o4g 150 24 ( ( -LRB- cord-256343-dtfw8o4g 150 25 noted note VBN cord-256343-dtfw8o4g 150 26 as as IN cord-256343-dtfw8o4g 150 27 NC NC NNP cord-256343-dtfw8o4g 150 28 in in IN cord-256343-dtfw8o4g 150 29 Table Table NNP cord-256343-dtfw8o4g 150 30 1 1 CD cord-256343-dtfw8o4g 150 31 ) ) -RRB- cord-256343-dtfw8o4g 150 32 were be VBD cord-256343-dtfw8o4g 150 33 only only RB cord-256343-dtfw8o4g 150 34 found find VBN cord-256343-dtfw8o4g 150 35 in in IN cord-256343-dtfw8o4g 150 36 A. a. NN cord-256343-dtfw8o4g 150 37 coronavirus coronavirus NN cord-256343-dtfw8o4g 150 38 genes gene NNS cord-256343-dtfw8o4g 150 39 and and CC cord-256343-dtfw8o4g 150 40 not not RB cord-256343-dtfw8o4g 150 41 in in IN cord-256343-dtfw8o4g 150 42 the the DT cord-256343-dtfw8o4g 150 43 G. G. NNP cord-256343-dtfw8o4g 150 44 gallus gallus NN cord-256343-dtfw8o4g 150 45 genes gene NNS cord-256343-dtfw8o4g 150 46 is be VBZ cord-256343-dtfw8o4g 150 47 that that IN cord-256343-dtfw8o4g 150 48 host host NN cord-256343-dtfw8o4g 150 49 genes gene NNS cord-256343-dtfw8o4g 150 50 are be VBP cord-256343-dtfw8o4g 150 51 less less RBR cord-256343-dtfw8o4g 150 52 susceptible susceptible JJ cord-256343-dtfw8o4g 150 53 to to IN cord-256343-dtfw8o4g 150 54 both both CC cord-256343-dtfw8o4g 150 55 the the DT cord-256343-dtfw8o4g 150 56 occurrence occurrence NN cord-256343-dtfw8o4g 150 57 of of IN cord-256343-dtfw8o4g 150 58 putative putative JJ cord-256343-dtfw8o4g 150 59 amino amino JJ cord-256343-dtfw8o4g 150 60 acids acid NNS cord-256343-dtfw8o4g 150 61 and and CC cord-256343-dtfw8o4g 150 62 codon codon NN cord-256343-dtfw8o4g 150 63 usage usage NN cord-256343-dtfw8o4g 150 64 polymorphisms polymorphism NNS cord-256343-dtfw8o4g 150 65 , , , cord-256343-dtfw8o4g 150 66 contrary contrary JJ cord-256343-dtfw8o4g 150 67 to to IN cord-256343-dtfw8o4g 150 68 what what WP cord-256343-dtfw8o4g 150 69 is be VBZ cord-256343-dtfw8o4g 150 70 observed observe VBN cord-256343-dtfw8o4g 150 71 and and CC cord-256343-dtfw8o4g 150 72 expected expect VBN cord-256343-dtfw8o4g 150 73 for for IN cord-256343-dtfw8o4g 150 74 virus virus NN cord-256343-dtfw8o4g 150 75 genes gene NNS cord-256343-dtfw8o4g 150 76 . . . cord-256343-dtfw8o4g 151 1 Nc Nc NNP cord-256343-dtfw8o4g 151 2 might may MD cord-256343-dtfw8o4g 151 3 be be VB cord-256343-dtfw8o4g 151 4 considered consider VBN cord-256343-dtfw8o4g 151 5 to to TO cord-256343-dtfw8o4g 151 6 be be VB cord-256343-dtfw8o4g 151 7 an an DT cord-256343-dtfw8o4g 151 8 accurate accurate JJ cord-256343-dtfw8o4g 151 9 indicator indicator NN cord-256343-dtfw8o4g 151 10 of of IN cord-256343-dtfw8o4g 151 11 codon codon NN cord-256343-dtfw8o4g 151 12 usage usage NN cord-256343-dtfw8o4g 151 13 bias bias NN cord-256343-dtfw8o4g 151 14 because because IN cord-256343-dtfw8o4g 151 15 the the DT cord-256343-dtfw8o4g 151 16 frequency frequency NN cord-256343-dtfw8o4g 151 17 of of IN cord-256343-dtfw8o4g 151 18 amino amino NN cord-256343-dtfw8o4g 151 19 acids acid NNS cord-256343-dtfw8o4g 151 20 is be VBZ cord-256343-dtfw8o4g 151 21 normalized normalize VBN cord-256343-dtfw8o4g 151 22 during during IN cord-256343-dtfw8o4g 151 23 the the DT cord-256343-dtfw8o4g 151 24 analysis analysis NN cord-256343-dtfw8o4g 151 25 and and CC cord-256343-dtfw8o4g 151 26 does do VBZ cord-256343-dtfw8o4g 151 27 not not RB cord-256343-dtfw8o4g 151 28 add add VB cord-256343-dtfw8o4g 151 29 bias bias NN cord-256343-dtfw8o4g 151 30 ; ; : cord-256343-dtfw8o4g 151 31 however however RB cord-256343-dtfw8o4g 151 32 , , , cord-256343-dtfw8o4g 151 33 similarly similarly RB cord-256343-dtfw8o4g 151 34 to to IN cord-256343-dtfw8o4g 151 35 the the DT cord-256343-dtfw8o4g 151 36 CAI CAI NNP cord-256343-dtfw8o4g 151 37 , , , cord-256343-dtfw8o4g 151 38 the the DT cord-256343-dtfw8o4g 151 39 outcome outcome NN cord-256343-dtfw8o4g 151 40 of of IN cord-256343-dtfw8o4g 151 41 the the DT cord-256343-dtfw8o4g 151 42 Nc Nc NNP cord-256343-dtfw8o4g 151 43 analysis analysis NN cord-256343-dtfw8o4g 151 44 is be VBZ cord-256343-dtfw8o4g 151 45 a a DT cord-256343-dtfw8o4g 151 46 single single JJ cord-256343-dtfw8o4g 151 47 number number NN cord-256343-dtfw8o4g 151 48 , , , cord-256343-dtfw8o4g 151 49 leading lead VBG cord-256343-dtfw8o4g 151 50 to to IN cord-256343-dtfw8o4g 151 51 a a DT cord-256343-dtfw8o4g 151 52 loss loss NN cord-256343-dtfw8o4g 151 53 of of IN cord-256343-dtfw8o4g 151 54 deep deep JJ cord-256343-dtfw8o4g 151 55 evolutionary evolutionary JJ cord-256343-dtfw8o4g 151 56 information information NN cord-256343-dtfw8o4g 151 57 similar similar JJ cord-256343-dtfw8o4g 151 58 to to IN cord-256343-dtfw8o4g 151 59 the the DT cord-256343-dtfw8o4g 151 60 loss loss NN cord-256343-dtfw8o4g 151 61 of of IN cord-256343-dtfw8o4g 151 62 evolutionary evolutionary JJ cord-256343-dtfw8o4g 151 63 information information NN cord-256343-dtfw8o4g 151 64 in in IN cord-256343-dtfw8o4g 151 65 nucleotide nucleotide JJ cord-256343-dtfw8o4g 151 66 or or CC cord-256343-dtfw8o4g 151 67 amino amino NN cord-256343-dtfw8o4g 151 68 acid acid NN cord-256343-dtfw8o4g 151 69 distance distance NN cord-256343-dtfw8o4g 151 70 - - HYPH cord-256343-dtfw8o4g 151 71 based base VBN cord-256343-dtfw8o4g 151 72 phylogenetic phylogenetic NN cord-256343-dtfw8o4g 151 73 analyses analysis NNS cord-256343-dtfw8o4g 151 74 . . . cord-256343-dtfw8o4g 152 1 Taking take VBG cord-256343-dtfw8o4g 152 2 into into IN cord-256343-dtfw8o4g 152 3 account account NN cord-256343-dtfw8o4g 152 4 informative informative JJ cord-256343-dtfw8o4g 152 5 sites site NNS cord-256343-dtfw8o4g 152 6 during during IN cord-256343-dtfw8o4g 152 7 codon codon NN cord-256343-dtfw8o4g 152 8 evolution evolution NN cord-256343-dtfw8o4g 152 9 studies study NNS cord-256343-dtfw8o4g 152 10 , , , cord-256343-dtfw8o4g 152 11 for for IN cord-256343-dtfw8o4g 152 12 instance instance NN cord-256343-dtfw8o4g 152 13 , , , cord-256343-dtfw8o4g 152 14 100 100 CD cord-256343-dtfw8o4g 152 15 % % NN cord-256343-dtfw8o4g 152 16 conserved conserve VBN cord-256343-dtfw8o4g 152 17 amino amino NN cord-256343-dtfw8o4g 152 18 acid acid NN cord-256343-dtfw8o4g 152 19 positions position NNS cord-256343-dtfw8o4g 152 20 coded code VBN cord-256343-dtfw8o4g 152 21 by by IN cord-256343-dtfw8o4g 152 22 the the DT cord-256343-dtfw8o4g 152 23 preferred preferred JJ cord-256343-dtfw8o4g 152 24 codon codon NN cord-256343-dtfw8o4g 152 25 for for IN cord-256343-dtfw8o4g 152 26 that that DT cord-256343-dtfw8o4g 152 27 amino amino NN cord-256343-dtfw8o4g 152 28 acid acid NN cord-256343-dtfw8o4g 152 29 , , , cord-256343-dtfw8o4g 152 30 could could MD cord-256343-dtfw8o4g 152 31 unveil unveil VB cord-256343-dtfw8o4g 152 32 data datum NNS cord-256343-dtfw8o4g 152 33 that that WDT cord-256343-dtfw8o4g 152 34 would would MD cord-256343-dtfw8o4g 152 35 otherwise otherwise RB cord-256343-dtfw8o4g 152 36 be be VB cord-256343-dtfw8o4g 152 37 lost lose VBN cord-256343-dtfw8o4g 152 38 in in IN cord-256343-dtfw8o4g 152 39 the the DT cord-256343-dtfw8o4g 152 40 analysis analysis NN cord-256343-dtfw8o4g 152 41 and and CC cord-256343-dtfw8o4g 152 42 that that DT cord-256343-dtfw8o4g 152 43 could could MD cord-256343-dtfw8o4g 152 44 be be VB cord-256343-dtfw8o4g 152 45 used use VBN cord-256343-dtfw8o4g 152 46 to to TO cord-256343-dtfw8o4g 152 47 gain gain VB cord-256343-dtfw8o4g 152 48 a a DT cord-256343-dtfw8o4g 152 49 more more RBR cord-256343-dtfw8o4g 152 50 comprehensive comprehensive JJ cord-256343-dtfw8o4g 152 51 understanding understanding NN cord-256343-dtfw8o4g 152 52 of of IN cord-256343-dtfw8o4g 152 53 molecular molecular JJ cord-256343-dtfw8o4g 152 54 evolution evolution NN cord-256343-dtfw8o4g 152 55 in in IN cord-256343-dtfw8o4g 152 56 association association NN cord-256343-dtfw8o4g 152 57 with with IN cord-256343-dtfw8o4g 152 58 the the DT cord-256343-dtfw8o4g 152 59 codon codon NN cord-256343-dtfw8o4g 152 60 usage usage NN cord-256343-dtfw8o4g 152 61 bias bias NN cord-256343-dtfw8o4g 152 62 indicators indicator NNS cord-256343-dtfw8o4g 152 63 and and CC cord-256343-dtfw8o4g 152 64 selection selection NN cord-256343-dtfw8o4g 152 65 analysis analysis NN cord-256343-dtfw8o4g 152 66 . . . cord-256343-dtfw8o4g 153 1 It -PRON- PRP cord-256343-dtfw8o4g 153 2 would would MD cord-256343-dtfw8o4g 153 3 be be VB cord-256343-dtfw8o4g 153 4 interesting interesting JJ cord-256343-dtfw8o4g 153 5 to to TO cord-256343-dtfw8o4g 153 6 use use VB cord-256343-dtfw8o4g 153 7 the the DT cord-256343-dtfw8o4g 153 8 analyses analysis NNS cord-256343-dtfw8o4g 153 9 presented present VBN cord-256343-dtfw8o4g 153 10 herein herein RB cord-256343-dtfw8o4g 153 11 not not RB cord-256343-dtfw8o4g 153 12 only only RB cord-256343-dtfw8o4g 153 13 for for IN cord-256343-dtfw8o4g 153 14 a a DT cord-256343-dtfw8o4g 153 15 better well JJR cord-256343-dtfw8o4g 153 16 understanding understanding NN cord-256343-dtfw8o4g 153 17 of of IN cord-256343-dtfw8o4g 153 18 virus virus NN cord-256343-dtfw8o4g 153 19 evolution evolution NN cord-256343-dtfw8o4g 153 20 but but CC cord-256343-dtfw8o4g 153 21 also also RB cord-256343-dtfw8o4g 153 22 as as IN cord-256343-dtfw8o4g 153 23 supporting support VBG cord-256343-dtfw8o4g 153 24 predictors predictor NNS cord-256343-dtfw8o4g 153 25 of of IN cord-256343-dtfw8o4g 153 26 spill spill NN cord-256343-dtfw8o4g 153 27 - - HYPH cord-256343-dtfw8o4g 153 28 over over RP cord-256343-dtfw8o4g 153 29 events event NNS cord-256343-dtfw8o4g 153 30 , , , cord-256343-dtfw8o4g 153 31 such such JJ cord-256343-dtfw8o4g 153 32 as as IN cord-256343-dtfw8o4g 153 33 influenza influenza NN cord-256343-dtfw8o4g 153 34 ( ( -LRB- cord-256343-dtfw8o4g 153 35 Wahlgren Wahlgren NNP cord-256343-dtfw8o4g 153 36 , , , cord-256343-dtfw8o4g 153 37 2011 2011 CD cord-256343-dtfw8o4g 153 38 ) ) -RRB- cord-256343-dtfw8o4g 153 39 and and CC cord-256343-dtfw8o4g 153 40 the the DT cord-256343-dtfw8o4g 153 41 new new JJ cord-256343-dtfw8o4g 153 42 human human JJ cord-256343-dtfw8o4g 153 43 coronavirus coronavirus NN cord-256343-dtfw8o4g 153 44 ( ( -LRB- cord-256343-dtfw8o4g 153 45 Kindler Kindler NNP cord-256343-dtfw8o4g 153 46 et et NNP cord-256343-dtfw8o4g 153 47 al al NNP cord-256343-dtfw8o4g 153 48 . . NNP cord-256343-dtfw8o4g 153 49 , , , cord-256343-dtfw8o4g 153 50 2013 2013 CD cord-256343-dtfw8o4g 153 51 ) ) -RRB- cord-256343-dtfw8o4g 153 52 now now RB cord-256343-dtfw8o4g 153 53 named name VBN cord-256343-dtfw8o4g 153 54 MERS MERS NNP cord-256343-dtfw8o4g 153 55 - - HYPH cord-256343-dtfw8o4g 153 56 CoV CoV NNP cord-256343-dtfw8o4g 153 57 , , , cord-256343-dtfw8o4g 153 58 for for IN cord-256343-dtfw8o4g 153 59 which which WDT cord-256343-dtfw8o4g 153 60 the the DT cord-256343-dtfw8o4g 153 61 role role NN cord-256343-dtfw8o4g 153 62 of of IN cord-256343-dtfw8o4g 153 63 codon codon NN cord-256343-dtfw8o4g 153 64 usage usage NN cord-256343-dtfw8o4g 153 65 evolution evolution NN cord-256343-dtfw8o4g 153 66 in in IN cord-256343-dtfw8o4g 153 67 virus virus NN cord-256343-dtfw8o4g 153 68 adaptation adaptation NN cord-256343-dtfw8o4g 153 69 to to IN cord-256343-dtfw8o4g 153 70 new new JJ cord-256343-dtfw8o4g 153 71 hosts host NNS cord-256343-dtfw8o4g 153 72 has have VBZ cord-256343-dtfw8o4g 153 73 been be VBN cord-256343-dtfw8o4g 153 74 widely widely RB cord-256343-dtfw8o4g 153 75 ignored ignore VBN cord-256343-dtfw8o4g 153 76 . . . cord-256343-dtfw8o4g 154 1 In in IN cord-256343-dtfw8o4g 154 2 conclusion conclusion NN cord-256343-dtfw8o4g 154 3 , , , cord-256343-dtfw8o4g 154 4 A. a. NN cord-256343-dtfw8o4g 154 5 coronavirus coronavirus NN cord-256343-dtfw8o4g 154 6 codon codon NN cord-256343-dtfw8o4g 154 7 usage usage NN cord-256343-dtfw8o4g 154 8 evolves evolve VBZ cord-256343-dtfw8o4g 154 9 independently independently RB cord-256343-dtfw8o4g 154 10 for for IN cord-256343-dtfw8o4g 154 11 each each DT cord-256343-dtfw8o4g 154 12 gene gene NN cord-256343-dtfw8o4g 154 13 in in IN cord-256343-dtfw8o4g 154 14 a a DT cord-256343-dtfw8o4g 154 15 manner manner NN cord-256343-dtfw8o4g 154 16 predictable predictable JJ cord-256343-dtfw8o4g 154 17 by by IN cord-256343-dtfw8o4g 154 18 the the DT cord-256343-dtfw8o4g 154 19 protein protein NN cord-256343-dtfw8o4g 154 20 function function NN cord-256343-dtfw8o4g 154 21 . . . cord-256343-dtfw8o4g 155 1 Proteins protein NNS cord-256343-dtfw8o4g 155 2 with with IN cord-256343-dtfw8o4g 155 3 high high JJ cord-256343-dtfw8o4g 155 4 functional functional JJ cord-256343-dtfw8o4g 155 5 and and CC cord-256343-dtfw8o4g 155 6 structural structural JJ cord-256343-dtfw8o4g 155 7 constraints constraint NNS cord-256343-dtfw8o4g 155 8 are be VBP cord-256343-dtfw8o4g 155 9 more more RBR cord-256343-dtfw8o4g 155 10 adapted adapt VBN cord-256343-dtfw8o4g 155 11 to to IN cord-256343-dtfw8o4g 155 12 G. G. NNP cord-256343-dtfw8o4g 155 13 gallus gallus NN cord-256343-dtfw8o4g 155 14 , , , cord-256343-dtfw8o4g 155 15 its -PRON- PRP$ cord-256343-dtfw8o4g 155 16 natural natural JJ cord-256343-dtfw8o4g 155 17 host host NN cord-256343-dtfw8o4g 155 18 , , , cord-256343-dtfw8o4g 155 19 with with IN cord-256343-dtfw8o4g 155 20 a a DT cord-256343-dtfw8o4g 155 21 balance balance NN cord-256343-dtfw8o4g 155 22 between between IN cord-256343-dtfw8o4g 155 23 natural natural JJ cord-256343-dtfw8o4g 155 24 selection selection NN cord-256343-dtfw8o4g 155 25 and and CC cord-256343-dtfw8o4g 155 26 mutation mutation NN cord-256343-dtfw8o4g 155 27 pressure pressure NN cord-256343-dtfw8o4g 155 28 , , , cord-256343-dtfw8o4g 155 29 giving give VBG cord-256343-dtfw8o4g 155 30 further further JJ cord-256343-dtfw8o4g 155 31 molecular molecular JJ cord-256343-dtfw8o4g 155 32 basis basis NN cord-256343-dtfw8o4g 155 33 for for IN cord-256343-dtfw8o4g 155 34 the the DT cord-256343-dtfw8o4g 155 35 virus virus NN cord-256343-dtfw8o4g 155 36 ' ' POS cord-256343-dtfw8o4g 155 37 ability ability NN cord-256343-dtfw8o4g 155 38 to to TO cord-256343-dtfw8o4g 155 39 exploit exploit VB cord-256343-dtfw8o4g 155 40 the the DT cord-256343-dtfw8o4g 155 41 host host NN cord-256343-dtfw8o4g 155 42 's 's POS cord-256343-dtfw8o4g 155 43 environment environment NN cord-256343-dtfw8o4g 155 44 . . . cord-256343-dtfw8o4g 156 1 Supplementary supplementary JJ cord-256343-dtfw8o4g 156 2 data datum NNS cord-256343-dtfw8o4g 156 3 associated associate VBN cord-256343-dtfw8o4g 156 4 with with IN cord-256343-dtfw8o4g 156 5 this this DT cord-256343-dtfw8o4g 156 6 article article NN cord-256343-dtfw8o4g 156 7 can can MD cord-256343-dtfw8o4g 156 8 be be VB cord-256343-dtfw8o4g 156 9 found find VBN cord-256343-dtfw8o4g 156 10 , , , cord-256343-dtfw8o4g 156 11 in in IN cord-256343-dtfw8o4g 156 12 the the DT cord-256343-dtfw8o4g 156 13 online online JJ cord-256343-dtfw8o4g 156 14 version version NN cord-256343-dtfw8o4g 156 15 , , , cord-256343-dtfw8o4g 156 16 at at IN cord-256343-dtfw8o4g 156 17 http://dx.doi.org/10.1016/j.virusres http://dx.doi.org/10.1016/j.virusres CD cord-256343-dtfw8o4g 156 18 . . . cord-256343-dtfw8o4g 157 1 2013.09.033 2013.09.033 CD cord-256343-dtfw8o4g 157 2 . . . cord-256343-dtfw8o4g 158 1 Fine fine JJ cord-256343-dtfw8o4g 158 2 - - HYPH cord-256343-dtfw8o4g 158 3 tuning tuning NN cord-256343-dtfw8o4g 158 4 translation translation NN cord-256343-dtfw8o4g 158 5 kinetics kinetics NN cord-256343-dtfw8o4g 158 6 selection selection NN cord-256343-dtfw8o4g 158 7 as as IN cord-256343-dtfw8o4g 158 8 the the DT cord-256343-dtfw8o4g 158 9 driving drive VBG cord-256343-dtfw8o4g 158 10 force force NN cord-256343-dtfw8o4g 158 11 of of IN cord-256343-dtfw8o4g 158 12 codon codon NNP cord-256343-dtfw8o4g 158 13 usage usage NN cord-256343-dtfw8o4g 158 14 bias bias NN cord-256343-dtfw8o4g 158 15 in in IN cord-256343-dtfw8o4g 158 16 hepatitis hepatitis NNP cord-256343-dtfw8o4g 158 17 A A NNP cord-256343-dtfw8o4g 158 18 virus virus NN cord-256343-dtfw8o4g 158 19 capsid capsid NN cord-256343-dtfw8o4g 158 20 Avian avian JJ cord-256343-dtfw8o4g 158 21 coronavirus coronavirus NN cord-256343-dtfw8o4g 158 22 spike spike NN cord-256343-dtfw8o4g 158 23 glycoprotein glycoprotein NN cord-256343-dtfw8o4g 158 24 ectodomain ectodomain NNP cord-256343-dtfw8o4g 158 25 shows show VBZ cord-256343-dtfw8o4g 158 26 a a DT cord-256343-dtfw8o4g 158 27 low low JJ cord-256343-dtfw8o4g 158 28 codon codon NN cord-256343-dtfw8o4g 158 29 adaptation adaptation NN cord-256343-dtfw8o4g 158 30 to to IN cord-256343-dtfw8o4g 158 31 Gallus Gallus NNP cord-256343-dtfw8o4g 158 32 gallus gallus NN cord-256343-dtfw8o4g 158 33 with with IN cord-256343-dtfw8o4g 158 34 virus virus NN cord-256343-dtfw8o4g 158 35 - - HYPH cord-256343-dtfw8o4g 158 36 exclusive exclusive JJ cord-256343-dtfw8o4g 158 37 codons codon NNS cord-256343-dtfw8o4g 158 38 in in IN cord-256343-dtfw8o4g 158 39 strategic strategic JJ cord-256343-dtfw8o4g 158 40 amino amino NN cord-256343-dtfw8o4g 158 41 acids acid NNS cord-256343-dtfw8o4g 158 42 positions position NNS cord-256343-dtfw8o4g 158 43 Base Base NNP cord-256343-dtfw8o4g 158 44 composition composition NN cord-256343-dtfw8o4g 158 45 and and CC cord-256343-dtfw8o4g 158 46 translational translational JJ cord-256343-dtfw8o4g 158 47 selection selection NN cord-256343-dtfw8o4g 158 48 are be VBP cord-256343-dtfw8o4g 158 49 insufficient insufficient JJ cord-256343-dtfw8o4g 158 50 to to TO cord-256343-dtfw8o4g 158 51 explain explain VB cord-256343-dtfw8o4g 158 52 codon codon NN cord-256343-dtfw8o4g 158 53 usage usage NN cord-256343-dtfw8o4g 158 54 bias bias NN cord-256343-dtfw8o4g 158 55 in in IN cord-256343-dtfw8o4g 158 56 plant plant NN cord-256343-dtfw8o4g 158 57 viruses virus NNS cord-256343-dtfw8o4g 159 1 Coronavirus Coronavirus NNP cord-256343-dtfw8o4g 159 2 avian avian JJ cord-256343-dtfw8o4g 159 3 infectious infectious JJ cord-256343-dtfw8o4g 159 4 bronchitis bronchitis NN cord-256343-dtfw8o4g 159 5 virus virus NN cord-256343-dtfw8o4g 159 6 Amino amino NN cord-256343-dtfw8o4g 159 7 acids acid NNS cord-256343-dtfw8o4g 159 8 within within IN cord-256343-dtfw8o4g 159 9 hypervariable hypervariable JJ cord-256343-dtfw8o4g 159 10 region1 region1 NN cord-256343-dtfw8o4g 159 11 of of IN cord-256343-dtfw8o4g 159 12 Avian avian JJ cord-256343-dtfw8o4g 159 13 coronavirus coronavirus NN cord-256343-dtfw8o4g 159 14 IBV IBV NNP cord-256343-dtfw8o4g 159 15 ( ( -LRB- cord-256343-dtfw8o4g 159 16 Massachusetts Massachusetts NNP cord-256343-dtfw8o4g 159 17 serotype serotype NN cord-256343-dtfw8o4g 159 18 ) ) -RRB- cord-256343-dtfw8o4g 159 19 spike spike NN cord-256343-dtfw8o4g 159 20 glycoprotein glycoprotein NN cord-256343-dtfw8o4g 159 21 are be VBP cord-256343-dtfw8o4g 159 22 associated associate VBN cord-256343-dtfw8o4g 159 23 with with IN cord-256343-dtfw8o4g 159 24 neutralization neutralization NN cord-256343-dtfw8o4g 159 25 epitopes epitope NNS cord-256343-dtfw8o4g 160 1 The the DT cord-256343-dtfw8o4g 160 2 long long JJ cord-256343-dtfw8o4g 160 3 view view NN cord-256343-dtfw8o4g 160 4 : : : cord-256343-dtfw8o4g 160 5 40 40 CD cord-256343-dtfw8o4g 160 6 years year NNS cord-256343-dtfw8o4g 160 7 of of IN cord-256343-dtfw8o4g 160 8 infectious infectious JJ cord-256343-dtfw8o4g 160 9 bronchitis bronchitis NN cord-256343-dtfw8o4g 160 10 research research NN cord-256343-dtfw8o4g 161 1 The the DT cord-256343-dtfw8o4g 161 2 nsp2 nsp2 NNP cord-256343-dtfw8o4g 161 3 replicase replicase NN cord-256343-dtfw8o4g 161 4 proteins protein NNS cord-256343-dtfw8o4g 161 5 of of IN cord-256343-dtfw8o4g 161 6 Murine Murine NNP cord-256343-dtfw8o4g 161 7 hepatitis hepatitis NN cord-256343-dtfw8o4g 161 8 virus virus NN cord-256343-dtfw8o4g 161 9 and and CC cord-256343-dtfw8o4g 161 10 Severe severe JJ cord-256343-dtfw8o4g 161 11 acute acute JJ cord-256343-dtfw8o4g 161 12 respiratory respiratory JJ cord-256343-dtfw8o4g 161 13 syndrome syndrome NN cord-256343-dtfw8o4g 161 14 coronavirus coronavirus NN cord-256343-dtfw8o4g 161 15 are be VBP cord-256343-dtfw8o4g 161 16 dispensable dispensable JJ cord-256343-dtfw8o4g 161 17 for for IN cord-256343-dtfw8o4g 161 18 viral viral JJ cord-256343-dtfw8o4g 161 19 replication replication NN cord-256343-dtfw8o4g 161 20 Analysis Analysis NNP cord-256343-dtfw8o4g 161 21 of of IN cord-256343-dtfw8o4g 161 22 synonymous synonymous JJ cord-256343-dtfw8o4g 161 23 codon codon NN cord-256343-dtfw8o4g 161 24 usage usage NN cord-256343-dtfw8o4g 161 25 in in IN cord-256343-dtfw8o4g 161 26 SARS SARS NNP cord-256343-dtfw8o4g 161 27 Coronavirus Coronavirus NNP cord-256343-dtfw8o4g 161 28 and and CC cord-256343-dtfw8o4g 161 29 other other JJ cord-256343-dtfw8o4g 161 30 viruses virus NNS cord-256343-dtfw8o4g 161 31 in in IN cord-256343-dtfw8o4g 161 32 the the DT cord-256343-dtfw8o4g 161 33 Nidovirales Nidovirales NNP cord-256343-dtfw8o4g 161 34 Selection Selection NNP cord-256343-dtfw8o4g 161 35 on on IN cord-256343-dtfw8o4g 161 36 codon codon NN cord-256343-dtfw8o4g 161 37 bias bias NN cord-256343-dtfw8o4g 161 38 Location location NN cord-256343-dtfw8o4g 161 39 of of IN cord-256343-dtfw8o4g 161 40 antigenic antigenic JJ cord-256343-dtfw8o4g 161 41 sites site NNS cord-256343-dtfw8o4g 161 42 defined define VBN cord-256343-dtfw8o4g 161 43 by by IN cord-256343-dtfw8o4g 161 44 neutralizing neutralize VBG cord-256343-dtfw8o4g 161 45 monoclonal monoclonal JJ cord-256343-dtfw8o4g 161 46 antibodies antibody NNS cord-256343-dtfw8o4g 161 47 on on IN cord-256343-dtfw8o4g 161 48 the the DT cord-256343-dtfw8o4g 161 49 S1 s1 NN cord-256343-dtfw8o4g 161 50 avian avian JJ cord-256343-dtfw8o4g 161 51 infectious infectious JJ cord-256343-dtfw8o4g 161 52 bronchitis bronchitis NN cord-256343-dtfw8o4g 161 53 virus virus NN cord-256343-dtfw8o4g 161 54 glycopolypeptide glycopolypeptide NN cord-256343-dtfw8o4g 161 55 Efficient efficient JJ cord-256343-dtfw8o4g 161 56 replication replication NN cord-256343-dtfw8o4g 161 57 of of IN cord-256343-dtfw8o4g 161 58 the the DT cord-256343-dtfw8o4g 161 59 novel novel NN cord-256343-dtfw8o4g 161 60 Human Human NNP cord-256343-dtfw8o4g 161 61 Betacoronavirus Betacoronavirus NNP cord-256343-dtfw8o4g 161 62 EMC EMC NNP cord-256343-dtfw8o4g 161 63 on on IN cord-256343-dtfw8o4g 161 64 primary primary JJ cord-256343-dtfw8o4g 161 65 human human JJ cord-256343-dtfw8o4g 161 66 epithelium epithelium NN cord-256343-dtfw8o4g 161 67 highlights highlight VBZ cord-256343-dtfw8o4g 161 68 its -PRON- PRP$ cord-256343-dtfw8o4g 161 69 zoonotic zoonotic JJ cord-256343-dtfw8o4g 161 70 potential potential JJ cord-256343-dtfw8o4g 161 71 Evolution evolution NN cord-256343-dtfw8o4g 161 72 of of IN cord-256343-dtfw8o4g 161 73 infectious infectious JJ cord-256343-dtfw8o4g 161 74 bronchitis bronchitis NN cord-256343-dtfw8o4g 161 75 virus virus NN cord-256343-dtfw8o4g 161 76 in in IN cord-256343-dtfw8o4g 161 77 Taiwan Taiwan NNP cord-256343-dtfw8o4g 161 78 : : : cord-256343-dtfw8o4g 161 79 positively positively RB cord-256343-dtfw8o4g 161 80 selected select VBN cord-256343-dtfw8o4g 161 81 sites site NNS cord-256343-dtfw8o4g 161 82 in in IN cord-256343-dtfw8o4g 161 83 the the DT cord-256343-dtfw8o4g 161 84 nucleocapsid nucleocapsid NNP cord-256343-dtfw8o4g 161 85 protein protein NN cord-256343-dtfw8o4g 161 86 and and CC cord-256343-dtfw8o4g 161 87 their -PRON- PRP$ cord-256343-dtfw8o4g 161 88 effects effect NNS cord-256343-dtfw8o4g 161 89 on on IN cord-256343-dtfw8o4g 161 90 RNA rna NN cord-256343-dtfw8o4g 161 91 - - HYPH cord-256343-dtfw8o4g 161 92 binding bind VBG cord-256343-dtfw8o4g 161 93 activity activity NN cord-256343-dtfw8o4g 162 1 The the DT cord-256343-dtfw8o4g 162 2 molecular molecular JJ cord-256343-dtfw8o4g 162 3 biology biology NN cord-256343-dtfw8o4g 162 4 of of IN cord-256343-dtfw8o4g 162 5 coronavirus coronavirus NN cord-256343-dtfw8o4g 162 6 Coronavirus Coronavirus NNP cord-256343-dtfw8o4g 162 7 genome genome NN cord-256343-dtfw8o4g 162 8 packaging packaging NN cord-256343-dtfw8o4g 162 9 Simple simple JJ cord-256343-dtfw8o4g 162 10 methods method NNS cord-256343-dtfw8o4g 162 11 for for IN cord-256343-dtfw8o4g 162 12 estimating estimate VBG cord-256343-dtfw8o4g 162 13 the the DT cord-256343-dtfw8o4g 162 14 numbers number NNS cord-256343-dtfw8o4g 162 15 of of IN cord-256343-dtfw8o4g 162 16 synonymous synonymous JJ cord-256343-dtfw8o4g 162 17 and and CC cord-256343-dtfw8o4g 162 18 nonsynonymous nonsynonymous JJ cord-256343-dtfw8o4g 162 19 nucleotide nucleotide JJ cord-256343-dtfw8o4g 162 20 substitutions substitution NNS cord-256343-dtfw8o4g 163 1 Molecular molecular JJ cord-256343-dtfw8o4g 163 2 Evolution Evolution NNP cord-256343-dtfw8o4g 163 3 and and CC cord-256343-dtfw8o4g 163 4 Phylogenetics Phylogenetics NNP cord-256343-dtfw8o4g 163 5 Mutation Mutation NNP cord-256343-dtfw8o4g 163 6 bias bias NN cord-256343-dtfw8o4g 163 7 is be VBZ cord-256343-dtfw8o4g 163 8 the the DT cord-256343-dtfw8o4g 163 9 driving drive VBG cord-256343-dtfw8o4g 163 10 force force NN cord-256343-dtfw8o4g 163 11 of of IN cord-256343-dtfw8o4g 163 12 codon codon NN cord-256343-dtfw8o4g 163 13 usage usage NN cord-256343-dtfw8o4g 163 14 in in IN cord-256343-dtfw8o4g 163 15 the the DT cord-256343-dtfw8o4g 163 16 Gallus Gallus NNP cord-256343-dtfw8o4g 163 17 gallus gallus NN cord-256343-dtfw8o4g 163 18 genome genome NN cord-256343-dtfw8o4g 164 1 Measuring measure VBG cord-256343-dtfw8o4g 164 2 codon codon NN cord-256343-dtfw8o4g 164 3 bias bias NN cord-256343-dtfw8o4g 165 1 The the DT cord-256343-dtfw8o4g 165 2 codon codon NN cord-256343-dtfw8o4g 165 3 Adaptation Adaptation NNP cord-256343-dtfw8o4g 165 4 Index Index NNP cord-256343-dtfw8o4g 165 5 - - , cord-256343-dtfw8o4g 165 6 a a DT cord-256343-dtfw8o4g 165 7 measure measure NN cord-256343-dtfw8o4g 165 8 of of IN cord-256343-dtfw8o4g 165 9 directional directional JJ cord-256343-dtfw8o4g 165 10 synonymous synonymous JJ cord-256343-dtfw8o4g 165 11 codon codon NN cord-256343-dtfw8o4g 165 12 usage usage NN cord-256343-dtfw8o4g 165 13 bias bias NN cord-256343-dtfw8o4g 165 14 , , , cord-256343-dtfw8o4g 165 15 and and CC cord-256343-dtfw8o4g 165 16 its -PRON- PRP$ cord-256343-dtfw8o4g 165 17 potential potential JJ cord-256343-dtfw8o4g 165 18 applications application NNS cord-256343-dtfw8o4g 165 19 PAUP PAUP NNP cord-256343-dtfw8o4g 165 20 * * NFP cord-256343-dtfw8o4g 165 21 , , , cord-256343-dtfw8o4g 165 22 Phylogenetic phylogenetic JJ cord-256343-dtfw8o4g 165 23 analysis analysis NN cord-256343-dtfw8o4g 165 24 using use VBG cord-256343-dtfw8o4g 165 25 parsimony parsimony NN cord-256343-dtfw8o4g 165 26 ( ( -LRB- cord-256343-dtfw8o4g 165 27 * * NFP cord-256343-dtfw8o4g 165 28 and and CC cord-256343-dtfw8o4g 165 29 Other other JJ cord-256343-dtfw8o4g 165 30 Methods Methods NNPS cord-256343-dtfw8o4g 165 31 ) ) -RRB- cord-256343-dtfw8o4g 165 32 . . . cord-256343-dtfw8o4g 166 1 Version version NN cord-256343-dtfw8o4g 166 2 4 4 CD cord-256343-dtfw8o4g 166 3 . . . cord-256343-dtfw8o4g 167 1 Sinauer Sinauer NNP cord-256343-dtfw8o4g 167 2 Associates Associates NNPS cord-256343-dtfw8o4g 168 1 MEGA5 MEGA5 NNP cord-256343-dtfw8o4g 168 2 : : : cord-256343-dtfw8o4g 169 1 molecular molecular JJ cord-256343-dtfw8o4g 169 2 evolutionary evolutionary JJ cord-256343-dtfw8o4g 169 3 genetics genetics NN cord-256343-dtfw8o4g 169 4 analysis analysis NN cord-256343-dtfw8o4g 169 5 using use VBG cord-256343-dtfw8o4g 169 6 maximum maximum JJ cord-256343-dtfw8o4g 169 7 likelihood likelihood NN cord-256343-dtfw8o4g 169 8 , , , cord-256343-dtfw8o4g 169 9 evolutionary evolutionary JJ cord-256343-dtfw8o4g 169 10 distance distance NN cord-256343-dtfw8o4g 169 11 , , , cord-256343-dtfw8o4g 169 12 and and CC cord-256343-dtfw8o4g 169 13 maximum maximum JJ cord-256343-dtfw8o4g 169 14 parsimony parsimony NN cord-256343-dtfw8o4g 169 15 methods method NNS cord-256343-dtfw8o4g 169 16 ACUA ACUA NNP cord-256343-dtfw8o4g 169 17 : : : cord-256343-dtfw8o4g 170 1 a a DT cord-256343-dtfw8o4g 170 2 software software NN cord-256343-dtfw8o4g 170 3 tool tool NN cord-256343-dtfw8o4g 170 4 for for IN cord-256343-dtfw8o4g 170 5 automated automate VBN cord-256343-dtfw8o4g 170 6 codon codon NN cord-256343-dtfw8o4g 170 7 usage usage NN cord-256343-dtfw8o4g 170 8 analysis analysis NN cord-256343-dtfw8o4g 171 1 Influenza Influenza NNP cord-256343-dtfw8o4g 171 2 A a DT cord-256343-dtfw8o4g 171 3 viruses virus NNS cord-256343-dtfw8o4g 171 4 : : : cord-256343-dtfw8o4g 172 1 an an DT cord-256343-dtfw8o4g 172 2 ecology ecology NN cord-256343-dtfw8o4g 172 3 review review NN cord-256343-dtfw8o4g 172 4 Binding Binding NNP cord-256343-dtfw8o4g 172 5 of of IN cord-256343-dtfw8o4g 172 6 Avian avian JJ cord-256343-dtfw8o4g 172 7 coronavirus coronavirus NN cord-256343-dtfw8o4g 172 8 spike spike NN cord-256343-dtfw8o4g 172 9 proteins protein NNS cord-256343-dtfw8o4g 172 10 to to IN cord-256343-dtfw8o4g 172 11 host host NN cord-256343-dtfw8o4g 172 12 factors factor NNS cord-256343-dtfw8o4g 172 13 reflects reflect VBZ cord-256343-dtfw8o4g 172 14 virus virus NN cord-256343-dtfw8o4g 172 15 tropism tropism NN cord-256343-dtfw8o4g 172 16 and and CC cord-256343-dtfw8o4g 172 17 pathogenicity pathogenicity NN cord-256343-dtfw8o4g 172 18 A a DT cord-256343-dtfw8o4g 172 19 phylogenetically phylogenetically RB cord-256343-dtfw8o4g 172 20 conserved conserve VBN cord-256343-dtfw8o4g 172 21 hairpin hairpin NN cord-256343-dtfw8o4g 172 22 - - HYPH cord-256343-dtfw8o4g 172 23 type type NN cord-256343-dtfw8o4g 172 24 3 3 CD cord-256343-dtfw8o4g 172 25 ' ' POS cord-256343-dtfw8o4g 172 26 untranslated untranslated JJ cord-256343-dtfw8o4g 172 27 region region NN cord-256343-dtfw8o4g 172 28 pseudoknot pseudoknot NNP cord-256343-dtfw8o4g 172 29 functions function NNS cord-256343-dtfw8o4g 172 30 in in IN cord-256343-dtfw8o4g 172 31 coronavirus coronavirus NN cord-256343-dtfw8o4g 172 32 RNA RNA NNP cord-256343-dtfw8o4g 172 33 replication replication NN cord-256343-dtfw8o4g 172 34 Infection infection NN cord-256343-dtfw8o4g 172 35 of of IN cord-256343-dtfw8o4g 172 36 the the DT cord-256343-dtfw8o4g 172 37 tracheal tracheal JJ cord-256343-dtfw8o4g 172 38 epithelium epithelium NN cord-256343-dtfw8o4g 172 39 by by IN cord-256343-dtfw8o4g 172 40 infectious infectious JJ cord-256343-dtfw8o4g 172 41 bronchitis bronchitis NN cord-256343-dtfw8o4g 172 42 virus virus NN cord-256343-dtfw8o4g 172 43 is be VBZ cord-256343-dtfw8o4g 172 44 sialic sialic JJ cord-256343-dtfw8o4g 172 45 acid acid NN cord-256343-dtfw8o4g 172 46 dependent dependent JJ cord-256343-dtfw8o4g 172 47 Discovery Discovery NNP cord-256343-dtfw8o4g 172 48 of of IN cord-256343-dtfw8o4g 172 49 seven seven CD cord-256343-dtfw8o4g 172 50 novel novel JJ cord-256343-dtfw8o4g 172 51 mammalian mammalian JJ cord-256343-dtfw8o4g 172 52 and and CC cord-256343-dtfw8o4g 172 53 avian avian JJ cord-256343-dtfw8o4g 172 54 coronaviruses coronaviruse NNS cord-256343-dtfw8o4g 172 55 in in IN cord-256343-dtfw8o4g 172 56 the the DT cord-256343-dtfw8o4g 172 57 genus genus NN cord-256343-dtfw8o4g 172 58 deltacoronavirus deltacoronavirus NN cord-256343-dtfw8o4g 173 1 supports support VBZ cord-256343-dtfw8o4g 173 2 bat bat NN cord-256343-dtfw8o4g 173 3 coronaviruses coronaviruse NNS cord-256343-dtfw8o4g 173 4 as as IN cord-256343-dtfw8o4g 173 5 the the DT cord-256343-dtfw8o4g 173 6 gene gene NN cord-256343-dtfw8o4g 173 7 source source NN cord-256343-dtfw8o4g 173 8 of of IN cord-256343-dtfw8o4g 173 9 alphacoronavirus alphacoronavirus NNP cord-256343-dtfw8o4g 173 10 and and CC cord-256343-dtfw8o4g 173 11 betacoronavirus betacoronavirus NNP cord-256343-dtfw8o4g 173 12 and and CC cord-256343-dtfw8o4g 173 13 avian avian JJ cord-256343-dtfw8o4g 173 14 coronaviruses coronaviruse NNS cord-256343-dtfw8o4g 173 15 as as IN cord-256343-dtfw8o4g 173 16 the the DT cord-256343-dtfw8o4g 173 17 gene gene NN cord-256343-dtfw8o4g 173 18 source source NN cord-256343-dtfw8o4g 173 19 of of IN cord-256343-dtfw8o4g 173 20 gammacoronavirus gammacoronavirus NNP cord-256343-dtfw8o4g 173 21 and and CC cord-256343-dtfw8o4g 173 22 deltacoronavirus deltacoronavirus NNP cord-256343-dtfw8o4g 174 1 The the DT cord-256343-dtfw8o4g 174 2 ' ' `` cord-256343-dtfw8o4g 174 3 effective effective JJ cord-256343-dtfw8o4g 174 4 number number NN cord-256343-dtfw8o4g 174 5 of of IN cord-256343-dtfw8o4g 174 6 codons codon NNS cord-256343-dtfw8o4g 174 7 ' ' POS cord-256343-dtfw8o4g 174 8 used use VBN cord-256343-dtfw8o4g 174 9 in in IN cord-256343-dtfw8o4g 174 10 a a DT cord-256343-dtfw8o4g 174 11 gene gene NN cord-256343-dtfw8o4g 174 12 Mutation mutation NN cord-256343-dtfw8o4g 174 13 - - HYPH cord-256343-dtfw8o4g 174 14 selection selection NN cord-256343-dtfw8o4g 174 15 models model NNS cord-256343-dtfw8o4g 174 16 of of IN cord-256343-dtfw8o4g 174 17 codon codon NN cord-256343-dtfw8o4g 174 18 substitution substitution NN cord-256343-dtfw8o4g 174 19 and and CC cord-256343-dtfw8o4g 174 20 their -PRON- PRP$ cord-256343-dtfw8o4g 174 21 use use NN cord-256343-dtfw8o4g 174 22 to to TO cord-256343-dtfw8o4g 174 23 estimate estimate VB cord-256343-dtfw8o4g 174 24 selective selective JJ cord-256343-dtfw8o4g 174 25 strengths strength NNS cord-256343-dtfw8o4g 174 26 on on IN cord-256343-dtfw8o4g 174 27 codon codon NN cord-256343-dtfw8o4g 174 28 usage usage NN cord-256343-dtfw8o4g 175 1 The the DT cord-256343-dtfw8o4g 175 2 coronavirus coronavirus NN cord-256343-dtfw8o4g 175 3 replicase replicase NN cord-256343-dtfw8o4g 175 4 gene gene NN cord-256343-dtfw8o4g 175 5 : : : cord-256343-dtfw8o4g 175 6 special special JJ cord-256343-dtfw8o4g 175 7 enzymes enzyme NNS cord-256343-dtfw8o4g 175 8 for for IN cord-256343-dtfw8o4g 175 9 special special JJ cord-256343-dtfw8o4g 175 10 viruses virus NNS cord-256343-dtfw8o4g 175 11 Virus virus NN cord-256343-dtfw8o4g 175 12 - - HYPH cord-256343-dtfw8o4g 175 13 encoded encode VBN cord-256343-dtfw8o4g 175 14 proteinases proteinase NNS cord-256343-dtfw8o4g 175 15 and and CC cord-256343-dtfw8o4g 175 16 proteolytic proteolytic JJ cord-256343-dtfw8o4g 175 17 processing processing NN cord-256343-dtfw8o4g 175 18 in in IN cord-256343-dtfw8o4g 175 19 the the DT cord-256343-dtfw8o4g 175 20 Nidovirales Nidovirales NNP cord-256343-dtfw8o4g 175 21 Analysis Analysis NNP cord-256343-dtfw8o4g 175 22 of of IN cord-256343-dtfw8o4g 175 23 base base NN cord-256343-dtfw8o4g 175 24 and and CC cord-256343-dtfw8o4g 175 25 codon codon NN cord-256343-dtfw8o4g 175 26 usage usage NN cord-256343-dtfw8o4g 175 27 by by IN cord-256343-dtfw8o4g 175 28 rubella rubella NN cord-256343-dtfw8o4g 175 29 virus virus NN