id	sid	tid	token	lemma	pos
cord-320331-wtxja5i9	1	1	key	key	NN
cord-320331-wtxja5i9	1	2	:	:	:
cord-320331-wtxja5i9	1	3	cord-320331-wtxja5i9	cord-320331-wtxja5i9	DT
cord-320331-wtxja5i9	1	4	authors	author	NNS
cord-320331-wtxja5i9	1	5	:	:	:
cord-320331-wtxja5i9	1	6	Cabbab	Cabbab	NNP
cord-320331-wtxja5i9	1	7	,	,	,
cord-320331-wtxja5i9	1	8	Iris	Iris	NNP
cord-320331-wtxja5i9	1	9	Louise	Louise	NNP
cord-320331-wtxja5i9	1	10	N.	N.	NNP
cord-320331-wtxja5i9	1	11	;	;	:
cord-320331-wtxja5i9	1	12	Manalo	Manalo	NNP
cord-320331-wtxja5i9	1	13	,	,	,
cord-320331-wtxja5i9	1	14	Rafael	Rafael	NNP
cord-320331-wtxja5i9	1	15	Vincent	Vincent	NNP
cord-320331-wtxja5i9	1	16	M.	M.	NNP
cord-320331-wtxja5i9	1	17	title	title	NN
cord-320331-wtxja5i9	1	18	:	:	:
cord-320331-wtxja5i9	1	19	Anti	anti	JJ
cord-320331-wtxja5i9	1	20	-	-	JJ
cord-320331-wtxja5i9	1	21	Inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	1	22	Drugs	drug	NNS
cord-320331-wtxja5i9	1	23	and	and	CC
cord-320331-wtxja5i9	1	24	the	the	DT
cord-320331-wtxja5i9	1	25	Renin	Renin	NNP
cord-320331-wtxja5i9	1	26	-	-	HYPH
cord-320331-wtxja5i9	1	27	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	1	28	-	-	HYPH
cord-320331-wtxja5i9	1	29	Aldosterone	Aldosterone	NNP
cord-320331-wtxja5i9	1	30	System	System	NNP
cord-320331-wtxja5i9	1	31	:	:	:
cord-320331-wtxja5i9	2	1	Current	current	JJ
cord-320331-wtxja5i9	2	2	Knowledge	Knowledge	NNP
cord-320331-wtxja5i9	2	3	and	and	CC
cord-320331-wtxja5i9	2	4	Potential	potential	JJ
cord-320331-wtxja5i9	2	5	Effects	effect	NNS
cord-320331-wtxja5i9	2	6	on	on	IN
cord-320331-wtxja5i9	2	7	Early	Early	NNP
cord-320331-wtxja5i9	2	8	SARS	SARS	NNP
cord-320331-wtxja5i9	2	9	-	-	HYPH
cord-320331-wtxja5i9	2	10	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	2	11	Infection	infection	NN
cord-320331-wtxja5i9	2	12	date	date	NN
cord-320331-wtxja5i9	2	13	:	:	:
cord-320331-wtxja5i9	2	14	2020	2020	CD
cord-320331-wtxja5i9	2	15	-	-	SYM
cord-320331-wtxja5i9	2	16	10	10	CD
cord-320331-wtxja5i9	2	17	-	-	HYPH
cord-320331-wtxja5i9	2	18	08	08	CD
cord-320331-wtxja5i9	2	19	journal	journal	NN
cord-320331-wtxja5i9	2	20	:	:	:
cord-320331-wtxja5i9	3	1	Virus	virus	NN
cord-320331-wtxja5i9	3	2	Res	Res	NNP
cord-320331-wtxja5i9	3	3	DOI	doi	NN
cord-320331-wtxja5i9	3	4	:	:	:
cord-320331-wtxja5i9	3	5	10.1016	10.1016	CD
cord-320331-wtxja5i9	3	6	/	/	SYM
cord-320331-wtxja5i9	3	7	j.virusres.2020.198190	j.virusres.2020.198190	NN
cord-320331-wtxja5i9	3	8	sha	sha	NNP
cord-320331-wtxja5i9	3	9	:	:	:
cord-320331-wtxja5i9	4	1	0520e04748e296bf0127ecad950b1129d12450c8	0520e04748e296bf0127ecad950b1129d12450c8	NFP
cord-320331-wtxja5i9	4	2	doc_id	doc_id	CD
cord-320331-wtxja5i9	4	3	:	:	:
cord-320331-wtxja5i9	4	4	320331	320331	CD
cord-320331-wtxja5i9	4	5	cord_uid	cord_uid	NN
cord-320331-wtxja5i9	4	6	:	:	:
cord-320331-wtxja5i9	5	1	wtxja5i9	wtxja5i9	NNP
cord-320331-wtxja5i9	5	2	Severe	severe	JJ
cord-320331-wtxja5i9	5	3	acute	acute	JJ
cord-320331-wtxja5i9	5	4	respiratory	respiratory	JJ
cord-320331-wtxja5i9	5	5	syndrome	syndrome	NN
cord-320331-wtxja5i9	5	6	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	5	7	2	2	CD
cord-320331-wtxja5i9	6	1	(	(	-LRB-
cord-320331-wtxja5i9	6	2	SARS	SARS	NNP
cord-320331-wtxja5i9	6	3	-	-	HYPH
cord-320331-wtxja5i9	6	4	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	6	5	)	)	-RRB-
cord-320331-wtxja5i9	6	6	is	be	VBZ
cord-320331-wtxja5i9	6	7	the	the	DT
cord-320331-wtxja5i9	6	8	etiologic	etiologic	JJ
cord-320331-wtxja5i9	6	9	agent	agent	NN
cord-320331-wtxja5i9	6	10	of	of	IN
cord-320331-wtxja5i9	6	11	coronavirus	coronavirus	NNP
cord-320331-wtxja5i9	6	12	disease	disease	NNP
cord-320331-wtxja5i9	6	13	19	19	CD
cord-320331-wtxja5i9	6	14	(	(	-LRB-
cord-320331-wtxja5i9	6	15	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	6	16	)	)	-RRB-
cord-320331-wtxja5i9	6	17	,	,	,
cord-320331-wtxja5i9	6	18	and	and	CC
cord-320331-wtxja5i9	6	19	is	be	VBZ
cord-320331-wtxja5i9	6	20	genetically	genetically	RB
cord-320331-wtxja5i9	6	21	related	relate	VBN
cord-320331-wtxja5i9	6	22	to	to	IN
cord-320331-wtxja5i9	6	23	the	the	DT
cord-320331-wtxja5i9	6	24	2003	2003	CD
cord-320331-wtxja5i9	6	25	SARS	SARS	NNP
cord-320331-wtxja5i9	6	26	and	and	CC
cord-320331-wtxja5i9	6	27	Middle	Middle	NNP
cord-320331-wtxja5i9	6	28	East	East	NNP
cord-320331-wtxja5i9	6	29	respiratory	respiratory	JJ
cord-320331-wtxja5i9	6	30	syndrome	syndrome	NN
cord-320331-wtxja5i9	6	31	(	(	-LRB-
cord-320331-wtxja5i9	6	32	MERS	MERS	NNP
cord-320331-wtxja5i9	6	33	-	-	HYPH
cord-320331-wtxja5i9	6	34	CoV	CoV	NNP
cord-320331-wtxja5i9	6	35	)	)	-RRB-
cord-320331-wtxja5i9	6	36	coronaviruses	coronaviruse	NNS
cord-320331-wtxja5i9	6	37	.	.	.
cord-320331-wtxja5i9	7	1	Recent	recent	JJ
cord-320331-wtxja5i9	7	2	studies	study	NNS
cord-320331-wtxja5i9	7	3	have	have	VBP
cord-320331-wtxja5i9	7	4	reported	report	VBN
cord-320331-wtxja5i9	7	5	that	that	IN
cord-320331-wtxja5i9	7	6	similar	similar	JJ
cord-320331-wtxja5i9	7	7	to	to	IN
cord-320331-wtxja5i9	7	8	SARS	SARS	NNP
cord-320331-wtxja5i9	7	9	-	-	HYPH
cord-320331-wtxja5i9	7	10	CoV	CoV	NNP
cord-320331-wtxja5i9	7	11	,	,	,
cord-320331-wtxja5i9	7	12	this	this	DT
cord-320331-wtxja5i9	7	13	strain	strain	NN
cord-320331-wtxja5i9	7	14	expresses	express	VBZ
cord-320331-wtxja5i9	7	15	a	a	DT
cord-320331-wtxja5i9	7	16	spike	spike	NN
cord-320331-wtxja5i9	7	17	protein	protein	NN
cord-320331-wtxja5i9	7	18	(	(	-LRB-
cord-320331-wtxja5i9	7	19	S	s	NN
cord-320331-wtxja5i9	7	20	)	)	-RRB-
cord-320331-wtxja5i9	7	21	with	with	IN
cord-320331-wtxja5i9	7	22	a	a	DT
cord-320331-wtxja5i9	7	23	receptor	receptor	NN
cord-320331-wtxja5i9	7	24	binding	bind	VBG
cord-320331-wtxja5i9	7	25	domain	domain	NN
cord-320331-wtxja5i9	7	26	(	(	-LRB-
cord-320331-wtxja5i9	7	27	RBD	RBD	NNP
cord-320331-wtxja5i9	7	28	)	)	-RRB-
cord-320331-wtxja5i9	7	29	that	that	WDT
cord-320331-wtxja5i9	7	30	binds	bind	VBZ
cord-320331-wtxja5i9	7	31	to	to	IN
cord-320331-wtxja5i9	7	32	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	7	33	-	-	HYPH
cord-320331-wtxja5i9	7	34	converting	convert	VBG
cord-320331-wtxja5i9	7	35	enzyme	enzyme	NN
cord-320331-wtxja5i9	7	36	2	2	CD
cord-320331-wtxja5i9	7	37	(	(	-LRB-
cord-320331-wtxja5i9	7	38	ACE2	ACE2	NNP
cord-320331-wtxja5i9	7	39	)	)	-RRB-
cord-320331-wtxja5i9	7	40	–	–	:
cord-320331-wtxja5i9	8	1	an	an	DT
cord-320331-wtxja5i9	8	2	enzyme	enzyme	NN
cord-320331-wtxja5i9	8	3	expressed	express	VBN
cord-320331-wtxja5i9	8	4	mostly	mostly	RB
cord-320331-wtxja5i9	8	5	in	in	IN
cord-320331-wtxja5i9	8	6	the	the	DT
cord-320331-wtxja5i9	8	7	endothelium	endothelium	NN
cord-320331-wtxja5i9	8	8	,	,	,
cord-320331-wtxja5i9	8	9	kidneys	kidney	NNS
cord-320331-wtxja5i9	8	10	,	,	,
cord-320331-wtxja5i9	8	11	heart	heart	NN
cord-320331-wtxja5i9	8	12	,	,	,
cord-320331-wtxja5i9	8	13	gastrointestinal	gastrointestinal	JJ
cord-320331-wtxja5i9	8	14	tract	tract	NN
cord-320331-wtxja5i9	8	15	and	and	CC
cord-320331-wtxja5i9	8	16	lungs	lung	NNS
cord-320331-wtxja5i9	8	17	–	–	:
cord-320331-wtxja5i9	8	18	to	to	TO
cord-320331-wtxja5i9	8	19	facilitate	facilitate	VB
cord-320331-wtxja5i9	8	20	viral	viral	JJ
cord-320331-wtxja5i9	8	21	entry	entry	NN
cord-320331-wtxja5i9	8	22	and	and	CC
cord-320331-wtxja5i9	8	23	intracellular	intracellular	JJ
cord-320331-wtxja5i9	8	24	replication	replication	NN
cord-320331-wtxja5i9	8	25	.	.	.
cord-320331-wtxja5i9	9	1	Incidentally	incidentally	RB
cord-320331-wtxja5i9	9	2	,	,	,
cord-320331-wtxja5i9	9	3	the	the	DT
cord-320331-wtxja5i9	9	4	renin	renin	NN
cord-320331-wtxja5i9	9	5	-	-	HYPH
cord-320331-wtxja5i9	9	6	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	9	7	-	-	HYPH
cord-320331-wtxja5i9	9	8	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	9	9	system	system	NN
cord-320331-wtxja5i9	9	10	(	(	-LRB-
cord-320331-wtxja5i9	9	11	RAAS	RAAS	NNP
cord-320331-wtxja5i9	9	12	)	)	-RRB-
cord-320331-wtxja5i9	9	13	is	be	VBZ
cord-320331-wtxja5i9	9	14	integral	integral	JJ
cord-320331-wtxja5i9	9	15	to	to	IN
cord-320331-wtxja5i9	9	16	physiologic	physiologic	JJ
cord-320331-wtxja5i9	9	17	control	control	NN
cord-320331-wtxja5i9	9	18	of	of	IN
cord-320331-wtxja5i9	9	19	both	both	CC
cord-320331-wtxja5i9	9	20	ACE	ACE	NNP
cord-320331-wtxja5i9	9	21	and	and	CC
cord-320331-wtxja5i9	9	22	ACE2	ACE2	NNP
cord-320331-wtxja5i9	9	23	expression	expression	NN
cord-320331-wtxja5i9	9	24	,	,	,
cord-320331-wtxja5i9	9	25	and	and	CC
cord-320331-wtxja5i9	9	26	is	be	VBZ
cord-320331-wtxja5i9	9	27	an	an	DT
cord-320331-wtxja5i9	9	28	essential	essential	JJ
cord-320331-wtxja5i9	9	29	system	system	NN
cord-320331-wtxja5i9	9	30	utilized	utilize	VBN
cord-320331-wtxja5i9	9	31	by	by	IN
cord-320331-wtxja5i9	9	32	SARS	SARS	NNP
cord-320331-wtxja5i9	9	33	-	-	HYPH
cord-320331-wtxja5i9	9	34	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	9	35	,	,	,
cord-320331-wtxja5i9	9	36	albeit	albeit	IN
cord-320331-wtxja5i9	9	37	with	with	IN
cord-320331-wtxja5i9	9	38	varying	vary	VBG
cord-320331-wtxja5i9	9	39	schools	school	NNS
cord-320331-wtxja5i9	9	40	of	of	IN
cord-320331-wtxja5i9	9	41	thought	thought	NN
cord-320331-wtxja5i9	9	42	on	on	IN
cord-320331-wtxja5i9	9	43	how	how	WRB
cord-320331-wtxja5i9	9	44	it	-PRON-	PRP
cord-320331-wtxja5i9	9	45	can	can	MD
cord-320331-wtxja5i9	9	46	affect	affect	VB
cord-320331-wtxja5i9	9	47	viral	viral	JJ
cord-320331-wtxja5i9	9	48	entry	entry	NN
cord-320331-wtxja5i9	9	49	.	.	.
cord-320331-wtxja5i9	10	1	In	in	IN
cord-320331-wtxja5i9	10	2	this	this	DT
cord-320331-wtxja5i9	10	3	paper	paper	NN
cord-320331-wtxja5i9	10	4	,	,	,
cord-320331-wtxja5i9	10	5	we	-PRON-	PRP
cord-320331-wtxja5i9	10	6	will	will	MD
cord-320331-wtxja5i9	10	7	review	review	VB
cord-320331-wtxja5i9	10	8	current	current	JJ
cord-320331-wtxja5i9	10	9	knowledge	knowledge	NN
cord-320331-wtxja5i9	10	10	on	on	IN
cord-320331-wtxja5i9	10	11	the	the	DT
cord-320331-wtxja5i9	10	12	RAAS	raa	NNS
cord-320331-wtxja5i9	10	13	and	and	CC
cord-320331-wtxja5i9	10	14	how	how	WRB
cord-320331-wtxja5i9	10	15	it	-PRON-	PRP
cord-320331-wtxja5i9	10	16	can	can	MD
cord-320331-wtxja5i9	10	17	be	be	VB
cord-320331-wtxja5i9	10	18	affected	affect	VBN
cord-320331-wtxja5i9	10	19	by	by	IN
cord-320331-wtxja5i9	10	20	non	non	JJ
cord-320331-wtxja5i9	10	21	-	-	JJ
cord-320331-wtxja5i9	10	22	steroidal	steroidal	JJ
cord-320331-wtxja5i9	10	23	anti	anti	JJ
cord-320331-wtxja5i9	10	24	-	-	JJ
cord-320331-wtxja5i9	10	25	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	10	26	drugs	drug	NNS
cord-320331-wtxja5i9	10	27	(	(	-LRB-
cord-320331-wtxja5i9	10	28	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	10	29	)	)	-RRB-
cord-320331-wtxja5i9	10	30	and	and	CC
cord-320331-wtxja5i9	10	31	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	10	32	use	use	NN
cord-320331-wtxja5i9	10	33	at	at	IN
cord-320331-wtxja5i9	10	34	the	the	DT
cord-320331-wtxja5i9	10	35	organ	organ	NN
cord-320331-wtxja5i9	10	36	and	and	CC
cord-320331-wtxja5i9	10	37	cellular	cellular	JJ
cord-320331-wtxja5i9	10	38	levels	level	NNS
cord-320331-wtxja5i9	10	39	.	.	.
cord-320331-wtxja5i9	11	1	We	-PRON-	PRP
cord-320331-wtxja5i9	11	2	will	will	MD
cord-320331-wtxja5i9	11	3	then	then	RB
cord-320331-wtxja5i9	11	4	discuss	discuss	VB
cord-320331-wtxja5i9	11	5	the	the	DT
cord-320331-wtxja5i9	11	6	relevance	relevance	NN
cord-320331-wtxja5i9	11	7	of	of	IN
cord-320331-wtxja5i9	11	8	these	these	DT
cord-320331-wtxja5i9	11	9	interactions	interaction	NNS
cord-320331-wtxja5i9	11	10	on	on	IN
cord-320331-wtxja5i9	11	11	organ	organ	NN
cord-320331-wtxja5i9	11	12	-	-	HYPH
cord-320331-wtxja5i9	11	13	specific	specific	JJ
cord-320331-wtxja5i9	11	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	11	15	expression	expression	NN
cord-320331-wtxja5i9	11	16	,	,	,
cord-320331-wtxja5i9	11	17	and	and	CC
cord-320331-wtxja5i9	11	18	provide	provide	VB
cord-320331-wtxja5i9	11	19	scientific	scientific	JJ
cord-320331-wtxja5i9	11	20	insights	insight	NNS
cord-320331-wtxja5i9	11	21	on	on	IN
cord-320331-wtxja5i9	11	22	how	how	WRB
cord-320331-wtxja5i9	11	23	this	this	DT
cord-320331-wtxja5i9	11	24	mechanism	mechanism	NN
cord-320331-wtxja5i9	11	25	can	can	MD
cord-320331-wtxja5i9	11	26	potentially	potentially	RB
cord-320331-wtxja5i9	11	27	affect	affect	VB
cord-320331-wtxja5i9	11	28	SARS	SARS	NNP
cord-320331-wtxja5i9	11	29	-	-	HYPH
cord-320331-wtxja5i9	11	30	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	11	31	infection	infection	NN
cord-320331-wtxja5i9	11	32	in	in	IN
cord-320331-wtxja5i9	11	33	the	the	DT
cord-320331-wtxja5i9	11	34	early	early	JJ
cord-320331-wtxja5i9	11	35	phases	phase	NNS
cord-320331-wtxja5i9	11	36	of	of	IN
cord-320331-wtxja5i9	11	37	disease	disease	NN
cord-320331-wtxja5i9	11	38	.	.	.
cord-320331-wtxja5i9	12	1	From	from	IN
cord-320331-wtxja5i9	12	2	the	the	DT
cord-320331-wtxja5i9	12	3	standpoint	standpoint	NN
cord-320331-wtxja5i9	12	4	of	of	IN
cord-320331-wtxja5i9	12	5	other	other	JJ
cord-320331-wtxja5i9	12	6	known	know	VBN
cord-320331-wtxja5i9	12	7	viruses	virus	NNS
cord-320331-wtxja5i9	12	8	,	,	,
cord-320331-wtxja5i9	12	9	we	-PRON-	PRP
cord-320331-wtxja5i9	12	10	will	will	MD
cord-320331-wtxja5i9	12	11	then	then	RB
cord-320331-wtxja5i9	12	12	aim	aim	VB
cord-320331-wtxja5i9	12	13	to	to	TO
cord-320331-wtxja5i9	12	14	discuss	discuss	VB
cord-320331-wtxja5i9	12	15	the	the	DT
cord-320331-wtxja5i9	12	16	potential	potential	JJ
cord-320331-wtxja5i9	12	17	uses	use	NNS
cord-320331-wtxja5i9	12	18	or	or	CC
cord-320331-wtxja5i9	12	19	restrictions	restriction	NNS
cord-320331-wtxja5i9	12	20	of	of	IN
cord-320331-wtxja5i9	12	21	these	these	DT
cord-320331-wtxja5i9	12	22	drugs	drug	NNS
cord-320331-wtxja5i9	12	23	in	in	IN
cord-320331-wtxja5i9	12	24	viral	viral	JJ
cord-320331-wtxja5i9	12	25	infection	infection	NN
cord-320331-wtxja5i9	12	26	,	,	,
cord-320331-wtxja5i9	12	27	and	and	CC
cord-320331-wtxja5i9	12	28	provide	provide	VB
cord-320331-wtxja5i9	12	29	an	an	DT
cord-320331-wtxja5i9	12	30	update	update	NN
cord-320331-wtxja5i9	12	31	on	on	IN
cord-320331-wtxja5i9	12	32	relevant	relevant	JJ
cord-320331-wtxja5i9	12	33	studies	study	NNS
cord-320331-wtxja5i9	12	34	about	about	IN
cord-320331-wtxja5i9	12	35	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	12	36	.	.	.
cord-320331-wtxja5i9	12	37	coagulation	coagulation	NN
cord-320331-wtxja5i9	12	38	(	(	-LRB-
cord-320331-wtxja5i9	12	39	DIC	DIC	NNP
cord-320331-wtxja5i9	12	40	)	)	-RRB-
cord-320331-wtxja5i9	12	41	.	.	.
cord-320331-wtxja5i9	13	1	Likewise	likewise	RB
cord-320331-wtxja5i9	13	2	,	,	,
cord-320331-wtxja5i9	13	3	it	-PRON-	PRP
cord-320331-wtxja5i9	13	4	is	be	VBZ
cord-320331-wtxja5i9	13	5	prudent	prudent	JJ
cord-320331-wtxja5i9	13	6	to	to	TO
cord-320331-wtxja5i9	13	7	assume	assume	VB
cord-320331-wtxja5i9	13	8	that	that	IN
cord-320331-wtxja5i9	13	9	CFR	CFR	NNP
cord-320331-wtxja5i9	13	10	is	be	VBZ
cord-320331-wtxja5i9	13	11	better	well	RBR
cord-320331-wtxja5i9	13	12	interpreted	interpret	VBN
cord-320331-wtxja5i9	13	13	after	after	IN
cord-320331-wtxja5i9	13	14	agestandardization	agestandardization	NN
cord-320331-wtxja5i9	13	15	is	be	VBZ
cord-320331-wtxja5i9	13	16	done	do	VBN
cord-320331-wtxja5i9	13	17	,	,	,
cord-320331-wtxja5i9	13	18	or	or	CC
cord-320331-wtxja5i9	13	19	when	when	WRB
cord-320331-wtxja5i9	13	20	it	-PRON-	PRP
cord-320331-wtxja5i9	13	21	is	be	VBZ
cord-320331-wtxja5i9	13	22	adjusted	adjust	VBN
cord-320331-wtxja5i9	13	23	for	for	IN
cord-320331-wtxja5i9	13	24	the	the	DT
cord-320331-wtxja5i9	13	25	presence	presence	NN
cord-320331-wtxja5i9	13	26	of	of	IN
cord-320331-wtxja5i9	13	27	comorbidity	comorbidity	NN
cord-320331-wtxja5i9	13	28	,	,	,
cord-320331-wtxja5i9	13	29	which	which	WDT
cord-320331-wtxja5i9	13	30	has	have	VBZ
cord-320331-wtxja5i9	13	31	been	be	VBN
cord-320331-wtxja5i9	13	32	done	do	VBN
cord-320331-wtxja5i9	13	33	in	in	IN
cord-320331-wtxja5i9	13	34	some	some	DT
cord-320331-wtxja5i9	13	35	reports	report	NNS
cord-320331-wtxja5i9	13	36	including	include	VBG
cord-320331-wtxja5i9	13	37	that	that	DT
cord-320331-wtxja5i9	13	38	of	of	IN
cord-320331-wtxja5i9	13	39	the	the	DT
cord-320331-wtxja5i9	13	40	Centers	Centers	NNPS
cord-320331-wtxja5i9	13	41	for	for	IN
cord-320331-wtxja5i9	13	42	Disease	Disease	NNP
cord-320331-wtxja5i9	13	43	Control	Control	NNP
cord-320331-wtxja5i9	13	44	and	and	CC
cord-320331-wtxja5i9	13	45	Prevention	Prevention	NNP
cord-320331-wtxja5i9	13	46	(	(	-LRB-
cord-320331-wtxja5i9	13	47	CDC	CDC	NNP
cord-320331-wtxja5i9	13	48	)	)	-RRB-
cord-320331-wtxja5i9	14	1	[	[	-LRB-
cord-320331-wtxja5i9	14	2	68	68	CD
cord-320331-wtxja5i9	14	3	]	]	-RRB-
cord-320331-wtxja5i9	14	4	.	.	.
cord-320331-wtxja5i9	15	1	A	a	DT
cord-320331-wtxja5i9	15	2	possible	possible	JJ
cord-320331-wtxja5i9	15	3	contributor	contributor	NN
cord-320331-wtxja5i9	15	4	to	to	IN
cord-320331-wtxja5i9	15	5	the	the	DT
cord-320331-wtxja5i9	15	6	risk	risk	NN
cord-320331-wtxja5i9	15	7	of	of	IN
cord-320331-wtxja5i9	15	8	severity	severity	NN
cord-320331-wtxja5i9	15	9	or	or	CC
cord-320331-wtxja5i9	15	10	to	to	IN
cord-320331-wtxja5i9	15	11	variations	variation	NNS
cord-320331-wtxja5i9	15	12	in	in	IN
cord-320331-wtxja5i9	15	13	the	the	DT
cord-320331-wtxja5i9	15	14	CFR	CFR	NNP
cord-320331-wtxja5i9	15	15	,	,	,
cord-320331-wtxja5i9	15	16	however	however	RB
cord-320331-wtxja5i9	15	17	,	,	,
cord-320331-wtxja5i9	15	18	may	may	MD
cord-320331-wtxja5i9	15	19	also	also	RB
cord-320331-wtxja5i9	15	20	come	come	VB
cord-320331-wtxja5i9	15	21	from	from	IN
cord-320331-wtxja5i9	15	22	the	the	DT
cord-320331-wtxja5i9	15	23	patient	patient	NN
cord-320331-wtxja5i9	15	24	's	's	POS
cord-320331-wtxja5i9	15	25	medications	medication	NNS
cord-320331-wtxja5i9	15	26	.	.	.
cord-320331-wtxja5i9	16	1	There	there	EX
cord-320331-wtxja5i9	16	2	have	have	VBP
cord-320331-wtxja5i9	16	3	been	be	VBN
cord-320331-wtxja5i9	16	4	studies	study	NNS
cord-320331-wtxja5i9	16	5	proposing	propose	VBG
cord-320331-wtxja5i9	16	6	that	that	IN
cord-320331-wtxja5i9	16	7	COVID-19	covid-19	CD
cord-320331-wtxja5i9	16	8	morbidity	morbidity	NN
cord-320331-wtxja5i9	16	9	and	and	CC
cord-320331-wtxja5i9	16	10	mortality	mortality	NN
cord-320331-wtxja5i9	16	11	are	be	VBP
cord-320331-wtxja5i9	16	12	a	a	DT
cord-320331-wtxja5i9	16	13	result	result	NN
cord-320331-wtxja5i9	16	14	of	of	IN
cord-320331-wtxja5i9	16	15	excessive	excessive	JJ
cord-320331-wtxja5i9	16	16	inflammation	inflammation	NN
cord-320331-wtxja5i9	16	17	,	,	,
cord-320331-wtxja5i9	16	18	such	such	JJ
cord-320331-wtxja5i9	16	19	as	as	IN
cord-320331-wtxja5i9	16	20	airway	airway	NN
cord-320331-wtxja5i9	16	21	inflammation	inflammation	NN
cord-320331-wtxja5i9	16	22	and	and	CC
cord-320331-wtxja5i9	16	23	cytokine	cytokine	NN
cord-320331-wtxja5i9	16	24	storms	storm	NNS
cord-320331-wtxja5i9	16	25	[	[	-LRB-
cord-320331-wtxja5i9	16	26	114	114	CD
cord-320331-wtxja5i9	16	27	]	]	-RRB-
cord-320331-wtxja5i9	16	28	,	,	,
cord-320331-wtxja5i9	16	29	and	and	CC
cord-320331-wtxja5i9	16	30	infected	infected	JJ
cord-320331-wtxja5i9	16	31	patients	patient	NNS
cord-320331-wtxja5i9	16	32	in	in	IN
cord-320331-wtxja5i9	16	33	the	the	DT
cord-320331-wtxja5i9	16	34	early	early	JJ
cord-320331-wtxja5i9	16	35	phases	phase	NNS
cord-320331-wtxja5i9	16	36	of	of	IN
cord-320331-wtxja5i9	16	37	disease	disease	NN
cord-320331-wtxja5i9	16	38	may	may	MD
cord-320331-wtxja5i9	16	39	experience	experience	VB
cord-320331-wtxja5i9	16	40	malaise	malaise	NN
cord-320331-wtxja5i9	16	41	or	or	CC
cord-320331-wtxja5i9	16	42	fever	fever	NN
cord-320331-wtxja5i9	16	43	and	and	CC
cord-320331-wtxja5i9	16	44	may	may	MD
cord-320331-wtxja5i9	16	45	seek	seek	VB
cord-320331-wtxja5i9	16	46	symptomatic	symptomatic	JJ
cord-320331-wtxja5i9	16	47	relief	relief	NN
cord-320331-wtxja5i9	16	48	through	through	IN
cord-320331-wtxja5i9	16	49	analgesics	analgesic	NNS
cord-320331-wtxja5i9	16	50	like	like	IN
cord-320331-wtxja5i9	16	51	paracetamol	paracetamol	JJ
cord-320331-wtxja5i9	16	52	and	and	CC
cord-320331-wtxja5i9	16	53	non	non	JJ
cord-320331-wtxja5i9	16	54	-	-	JJ
cord-320331-wtxja5i9	16	55	steroidal	steroidal	JJ
cord-320331-wtxja5i9	16	56	anti	anti	JJ
cord-320331-wtxja5i9	16	57	-	-	JJ
cord-320331-wtxja5i9	16	58	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	16	59	drugs	drug	NNS
cord-320331-wtxja5i9	16	60	(	(	-LRB-
cord-320331-wtxja5i9	16	61	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	16	62	)	)	-RRB-
cord-320331-wtxja5i9	16	63	such	such	JJ
cord-320331-wtxja5i9	16	64	as	as	IN
cord-320331-wtxja5i9	16	65	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	16	66	.	.	.
cord-320331-wtxja5i9	17	1	Similarly	similarly	RB
cord-320331-wtxja5i9	17	2	,	,	,
cord-320331-wtxja5i9	17	3	patients	patient	NNS
cord-320331-wtxja5i9	17	4	with	with	IN
cord-320331-wtxja5i9	17	5	chronic	chronic	JJ
cord-320331-wtxja5i9	17	6	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	17	7	diseases	disease	NNS
cord-320331-wtxja5i9	17	8	may	may	MD
cord-320331-wtxja5i9	17	9	take	take	VB
cord-320331-wtxja5i9	17	10	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	17	11	or	or	CC
cord-320331-wtxja5i9	17	12	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	17	13	as	as	IN
cord-320331-wtxja5i9	17	14	management	management	NN
cord-320331-wtxja5i9	17	15	for	for	IN
cord-320331-wtxja5i9	17	16	their	-PRON-	PRP$
cord-320331-wtxja5i9	17	17	disease	disease	NN
cord-320331-wtxja5i9	17	18	,	,	,
cord-320331-wtxja5i9	17	19	which	which	WDT
cord-320331-wtxja5i9	17	20	may	may	MD
cord-320331-wtxja5i9	17	21	increase	increase	VB
cord-320331-wtxja5i9	17	22	their	-PRON-	PRP$
cord-320331-wtxja5i9	17	23	susceptibility	susceptibility	NN
cord-320331-wtxja5i9	17	24	to	to	IN
cord-320331-wtxja5i9	17	25	microbial	microbial	JJ
cord-320331-wtxja5i9	17	26	infection	infection	NN
cord-320331-wtxja5i9	17	27	.	.	.
cord-320331-wtxja5i9	18	1	Since	since	IN
cord-320331-wtxja5i9	18	2	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	18	3	is	be	VBZ
cord-320331-wtxja5i9	18	4	a	a	DT
cord-320331-wtxja5i9	18	5	viral	viral	JJ
cord-320331-wtxja5i9	18	6	illness	illness	NN
cord-320331-wtxja5i9	18	7	,	,	,
cord-320331-wtxja5i9	18	8	there	there	EX
cord-320331-wtxja5i9	18	9	have	have	VBP
cord-320331-wtxja5i9	18	10	been	be	VBN
cord-320331-wtxja5i9	18	11	concerns	concern	NNS
cord-320331-wtxja5i9	18	12	that	that	IN
cord-320331-wtxja5i9	18	13	anti	anti	JJ
cord-320331-wtxja5i9	18	14	-	-	JJ
cord-320331-wtxja5i9	18	15	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	18	16	drug	drug	NN
cord-320331-wtxja5i9	18	17	use	use	NN
cord-320331-wtxja5i9	18	18	can	can	MD
cord-320331-wtxja5i9	18	19	aggravate	aggravate	VB
cord-320331-wtxja5i9	18	20	SARS	SARS	NNP
cord-320331-wtxja5i9	18	21	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	18	22	infections	infection	NNS
cord-320331-wtxja5i9	18	23	[	[	-LRB-
cord-320331-wtxja5i9	18	24	20	20	CD
cord-320331-wtxja5i9	18	25	,	,	,
cord-320331-wtxja5i9	18	26	45	45	CD
cord-320331-wtxja5i9	18	27	]	]	-RRB-
cord-320331-wtxja5i9	18	28	,	,	,
cord-320331-wtxja5i9	18	29	but	but	CC
cord-320331-wtxja5i9	18	30	evidence	evidence	NN
cord-320331-wtxja5i9	18	31	on	on	IN
cord-320331-wtxja5i9	18	32	this	this	DT
cord-320331-wtxja5i9	18	33	speculation	speculation	NN
cord-320331-wtxja5i9	18	34	has	have	VBZ
cord-320331-wtxja5i9	18	35	not	not	RB
cord-320331-wtxja5i9	18	36	been	be	VBN
cord-320331-wtxja5i9	18	37	unified	unify	VBN
cord-320331-wtxja5i9	18	38	and	and	CC
cord-320331-wtxja5i9	18	39	is	be	VBZ
cord-320331-wtxja5i9	18	40	even	even	RB
cord-320331-wtxja5i9	18	41	contradicting	contradict	VBG
cord-320331-wtxja5i9	18	42	.	.	.
cord-320331-wtxja5i9	19	1	Interestingly	interestingly	RB
cord-320331-wtxja5i9	19	2	,	,	,
cord-320331-wtxja5i9	19	3	the	the	DT
cord-320331-wtxja5i9	19	4	membrane	membrane	NN
cord-320331-wtxja5i9	19	5	receptor	receptor	NN
cord-320331-wtxja5i9	19	6	of	of	IN
cord-320331-wtxja5i9	19	7	SARS	SARS	NNP
cord-320331-wtxja5i9	19	8	-	-	HYPH
cord-320331-wtxja5i9	19	9	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	19	10	,	,	,
cord-320331-wtxja5i9	19	11	which	which	WDT
cord-320331-wtxja5i9	19	12	is	be	VBZ
cord-320331-wtxja5i9	19	13	ACE2	ACE2	NNP
cord-320331-wtxja5i9	19	14	,	,	,
cord-320331-wtxja5i9	19	15	is	be	VBZ
cord-320331-wtxja5i9	19	16	an	an	DT
cord-320331-wtxja5i9	19	17	essential	essential	JJ
cord-320331-wtxja5i9	19	18	component	component	NN
cord-320331-wtxja5i9	19	19	of	of	IN
cord-320331-wtxja5i9	19	20	the	the	DT
cord-320331-wtxja5i9	19	21	regulatory	regulatory	JJ
cord-320331-wtxja5i9	19	22	mechanism	mechanism	NN
cord-320331-wtxja5i9	19	23	of	of	IN
cord-320331-wtxja5i9	19	24	the	the	DT
cord-320331-wtxja5i9	19	25	renin	renin	NN
cord-320331-wtxja5i9	19	26	-	-	HYPH
cord-320331-wtxja5i9	19	27	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	19	28	-	-	HYPH
cord-320331-wtxja5i9	19	29	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	19	30	system	system	NN
cord-320331-wtxja5i9	19	31	(	(	-LRB-
cord-320331-wtxja5i9	19	32	RAAS	RAAS	NNP
cord-320331-wtxja5i9	19	33	)	)	-RRB-
cord-320331-wtxja5i9	19	34	,	,	,
cord-320331-wtxja5i9	19	35	and	and	CC
cord-320331-wtxja5i9	19	36	this	this	DT
cord-320331-wtxja5i9	19	37	hormone	hormone	NN
cord-320331-wtxja5i9	19	38	pathway	pathway	NN
cord-320331-wtxja5i9	19	39	may	may	MD
cord-320331-wtxja5i9	19	40	interact	interact	VB
cord-320331-wtxja5i9	19	41	with	with	IN
cord-320331-wtxja5i9	19	42	the	the	DT
cord-320331-wtxja5i9	19	43	pathophysiology	pathophysiology	NN
cord-320331-wtxja5i9	19	44	of	of	IN
cord-320331-wtxja5i9	19	45	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	19	46	.	.	.
cord-320331-wtxja5i9	20	1	To	to	IN
cord-320331-wtxja5i9	20	2	this	this	DT
cord-320331-wtxja5i9	20	3	end	end	NN
cord-320331-wtxja5i9	20	4	,	,	,
cord-320331-wtxja5i9	20	5	this	this	DT
cord-320331-wtxja5i9	20	6	paper	paper	NN
cord-320331-wtxja5i9	20	7	will	will	MD
cord-320331-wtxja5i9	20	8	review	review	VB
cord-320331-wtxja5i9	20	9	the	the	DT
cord-320331-wtxja5i9	20	10	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	20	11	of	of	IN
cord-320331-wtxja5i9	20	12	the	the	DT
cord-320331-wtxja5i9	20	13	RAAS	raa	NNS
cord-320331-wtxja5i9	20	14	and	and	CC
cord-320331-wtxja5i9	20	15	its	-PRON-	PRP$
cord-320331-wtxja5i9	20	16	coincidence	coincidence	NN
cord-320331-wtxja5i9	20	17	with	with	IN
cord-320331-wtxja5i9	20	18	the	the	DT
cord-320331-wtxja5i9	20	19	anti	anti	JJ
cord-320331-wtxja5i9	20	20	-	-	JJ
cord-320331-wtxja5i9	20	21	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	20	22	pathways	pathway	NNS
cord-320331-wtxja5i9	20	23	of	of	IN
cord-320331-wtxja5i9	20	24	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	20	25	and	and	CC
cord-320331-wtxja5i9	20	26	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	20	27	both	both	CC
cord-320331-wtxja5i9	20	28	at	at	IN
cord-320331-wtxja5i9	20	29	the	the	DT
cord-320331-wtxja5i9	20	30	cellular	cellular	JJ
cord-320331-wtxja5i9	20	31	and	and	CC
cord-320331-wtxja5i9	20	32	organ	organ	NN
cord-320331-wtxja5i9	20	33	levels	level	NNS
cord-320331-wtxja5i9	20	34	.	.	.
cord-320331-wtxja5i9	21	1	We	-PRON-	PRP
cord-320331-wtxja5i9	21	2	will	will	MD
cord-320331-wtxja5i9	21	3	discuss	discuss	VB
cord-320331-wtxja5i9	21	4	current	current	JJ
cord-320331-wtxja5i9	21	5	evidence	evidence	NN
cord-320331-wtxja5i9	21	6	on	on	IN
cord-320331-wtxja5i9	21	7	the	the	DT
cord-320331-wtxja5i9	21	8	effects	effect	NNS
cord-320331-wtxja5i9	21	9	of	of	IN
cord-320331-wtxja5i9	21	10	these	these	DT
cord-320331-wtxja5i9	21	11	anti	anti	JJ
cord-320331-wtxja5i9	21	12	-	-	JJ
cord-320331-wtxja5i9	21	13	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	21	14	drugs	drug	NNS
cord-320331-wtxja5i9	21	15	on	on	IN
cord-320331-wtxja5i9	21	16	SARS	SARS	NNP
cord-320331-wtxja5i9	21	17	-	-	HYPH
cord-320331-wtxja5i9	21	18	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	21	19	infection	infection	NN
cord-320331-wtxja5i9	21	20	,	,	,
cord-320331-wtxja5i9	21	21	as	as	RB
cord-320331-wtxja5i9	21	22	well	well	RB
cord-320331-wtxja5i9	21	23	as	as	IN
cord-320331-wtxja5i9	21	24	the	the	DT
cord-320331-wtxja5i9	21	25	potential	potential	JJ
cord-320331-wtxja5i9	21	26	interactions	interaction	NNS
cord-320331-wtxja5i9	21	27	of	of	IN
cord-320331-wtxja5i9	21	28	pathways	pathway	NNS
cord-320331-wtxja5i9	21	29	upstream	upstream	RB
cord-320331-wtxja5i9	21	30	or	or	CC
cord-320331-wtxja5i9	21	31	downstream	downstream	RB
cord-320331-wtxja5i9	21	32	of	of	IN
cord-320331-wtxja5i9	21	33	ACE2	ACE2	NNP
cord-320331-wtxja5i9	21	34	on	on	IN
cord-320331-wtxja5i9	21	35	the	the	DT
cord-320331-wtxja5i9	21	36	RAAS	raa	NNS
cord-320331-wtxja5i9	21	37	,	,	,
cord-320331-wtxja5i9	21	38	in	in	IN
cord-320331-wtxja5i9	21	39	an	an	DT
cord-320331-wtxja5i9	21	40	effort	effort	NN
cord-320331-wtxja5i9	21	41	to	to	TO
cord-320331-wtxja5i9	21	42	bridge	bridge	VB
cord-320331-wtxja5i9	21	43	these	these	DT
cord-320331-wtxja5i9	21	44	pathways	pathway	NNS
cord-320331-wtxja5i9	21	45	in	in	IN
cord-320331-wtxja5i9	21	46	the	the	DT
cord-320331-wtxja5i9	21	47	setting	setting	NN
cord-320331-wtxja5i9	21	48	of	of	IN
cord-320331-wtxja5i9	21	49	COVID-19	covid-19	NN
cord-320331-wtxja5i9	21	50	.	.	.
cord-320331-wtxja5i9	22	1	Based	base	VBN
cord-320331-wtxja5i9	22	2	on	on	IN
cord-320331-wtxja5i9	22	3	the	the	DT
cord-320331-wtxja5i9	22	4	evidence	evidence	NN
cord-320331-wtxja5i9	22	5	collated	collate	VBN
cord-320331-wtxja5i9	22	6	,	,	,
cord-320331-wtxja5i9	22	7	we	-PRON-	PRP
cord-320331-wtxja5i9	22	8	will	will	MD
cord-320331-wtxja5i9	22	9	then	then	RB
cord-320331-wtxja5i9	22	10	compare	compare	VB
cord-320331-wtxja5i9	22	11	the	the	DT
cord-320331-wtxja5i9	22	12	anti	anti	JJ
cord-320331-wtxja5i9	22	13	-	-	JJ
cord-320331-wtxja5i9	22	14	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	22	15	drug	drug	NN
cord-320331-wtxja5i9	22	16	classes	class	NNS
cord-320331-wtxja5i9	22	17	included	include	VBN
cord-320331-wtxja5i9	22	18	in	in	IN
cord-320331-wtxja5i9	22	19	this	this	DT
cord-320331-wtxja5i9	22	20	review	review	NN
cord-320331-wtxja5i9	22	21	to	to	TO
cord-320331-wtxja5i9	22	22	determine	determine	VB
cord-320331-wtxja5i9	22	23	the	the	DT
cord-320331-wtxja5i9	22	24	potential	potential	JJ
cord-320331-wtxja5i9	22	25	uses	use	NNS
cord-320331-wtxja5i9	22	26	or	or	CC
cord-320331-wtxja5i9	22	27	restrictions	restriction	NNS
cord-320331-wtxja5i9	22	28	of	of	IN
cord-320331-wtxja5i9	22	29	these	these	DT
cord-320331-wtxja5i9	22	30	drugs	drug	NNS
cord-320331-wtxja5i9	22	31	in	in	IN
cord-320331-wtxja5i9	22	32	early	early	JJ
cord-320331-wtxja5i9	22	33	SARS	SARS	NNP
cord-320331-wtxja5i9	22	34	-	-	HYPH
cord-320331-wtxja5i9	22	35	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	22	36	infection	infection	NN
cord-320331-wtxja5i9	22	37	.	.	.
cord-320331-wtxja5i9	23	1	For	for	IN
cord-320331-wtxja5i9	23	2	this	this	DT
cord-320331-wtxja5i9	23	3	review	review	NN
cord-320331-wtxja5i9	23	4	,	,	,
cord-320331-wtxja5i9	23	5	we	-PRON-	PRP
cord-320331-wtxja5i9	23	6	did	do	VBD
cord-320331-wtxja5i9	23	7	a	a	DT
cord-320331-wtxja5i9	23	8	literature	literature	NN
cord-320331-wtxja5i9	23	9	search	search	NN
cord-320331-wtxja5i9	23	10	at	at	IN
cord-320331-wtxja5i9	23	11	NCBI	NCBI	NNP
cord-320331-wtxja5i9	23	12	PubMed	PubMed	NNP
cord-320331-wtxja5i9	23	13	and	and	CC
cord-320331-wtxja5i9	23	14	MEDLINE	MEDLINE	NNP
cord-320331-wtxja5i9	23	15	databases	database	NNS
cord-320331-wtxja5i9	23	16	to	to	TO
cord-320331-wtxja5i9	23	17	gather	gather	VB
cord-320331-wtxja5i9	23	18	current	current	JJ
cord-320331-wtxja5i9	23	19	studies	study	NNS
cord-320331-wtxja5i9	23	20	on	on	IN
cord-320331-wtxja5i9	23	21	the	the	DT
cord-320331-wtxja5i9	23	22	COVID-19-RAAS	covid-19-raas	NN
cord-320331-wtxja5i9	23	23	-	-	HYPH
cord-320331-wtxja5i9	23	24	anti	anti	JJ
cord-320331-wtxja5i9	23	25	-	-	JJ
cord-320331-wtxja5i9	23	26	Inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	23	27	drug	drug	NN
cord-320331-wtxja5i9	23	28	interactions	interaction	NNS
cord-320331-wtxja5i9	23	29	using	use	VBG
cord-320331-wtxja5i9	23	30	the	the	DT
cord-320331-wtxja5i9	23	31	terms	term	NNS
cord-320331-wtxja5i9	23	32	'	'	POS
cord-320331-wtxja5i9	23	33	SARS	SARS	NNP
cord-320331-wtxja5i9	23	34	-	-	HYPH
cord-320331-wtxja5i9	23	35	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	23	36	'	'	''
cord-320331-wtxja5i9	23	37	or	or	CC
cord-320331-wtxja5i9	23	38	'	'	``
cord-320331-wtxja5i9	23	39	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	23	40	'	'	''
cord-320331-wtxja5i9	23	41	,	,	,
cord-320331-wtxja5i9	23	42	matched	match	VBN
cord-320331-wtxja5i9	23	43	with	with	IN
cord-320331-wtxja5i9	23	44	'	'	``
cord-320331-wtxja5i9	23	45	renin	renin	NN
cord-320331-wtxja5i9	23	46	-	-	HYPH
cord-320331-wtxja5i9	23	47	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	23	48	system	system	NN
cord-320331-wtxja5i9	23	49	'	'	''
cord-320331-wtxja5i9	23	50	,	,	,
cord-320331-wtxja5i9	23	51	'	'	``
cord-320331-wtxja5i9	23	52	renin	renin	NN
cord-320331-wtxja5i9	23	53	-	-	HYPH
cord-320331-wtxja5i9	23	54	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	23	55	-	-	HYPH
cord-320331-wtxja5i9	23	56	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	23	57	-	-	HYPH
cord-320331-wtxja5i9	23	58	system	system	NN
cord-320331-wtxja5i9	23	59	'	'	''
cord-320331-wtxja5i9	23	60	,	,	,
cord-320331-wtxja5i9	23	61	'	'	``
cord-320331-wtxja5i9	23	62	RAAS	RAAS	NNP
cord-320331-wtxja5i9	23	63	'	'	POS
cord-320331-wtxja5i9	23	64	or	or	CC
cord-320331-wtxja5i9	23	65	'	'	``
cord-320331-wtxja5i9	23	66	RAS	RAS	NNP
cord-320331-wtxja5i9	23	67	'	'	''
cord-320331-wtxja5i9	23	68	,	,	,
cord-320331-wtxja5i9	23	69	which	which	WDT
cord-320331-wtxja5i9	23	70	yielded	yield	VBD
cord-320331-wtxja5i9	23	71	374	374	CD
cord-320331-wtxja5i9	23	72	unique	unique	JJ
cord-320331-wtxja5i9	23	73	results	result	NNS
cord-320331-wtxja5i9	23	74	.	.	.
cord-320331-wtxja5i9	24	1	We	-PRON-	PRP
cord-320331-wtxja5i9	24	2	further	further	RB
cord-320331-wtxja5i9	24	3	narrowed	narrow	VBD
cord-320331-wtxja5i9	24	4	the	the	DT
cord-320331-wtxja5i9	24	5	search	search	NN
cord-320331-wtxja5i9	24	6	by	by	IN
cord-320331-wtxja5i9	24	7	including	include	VBG
cord-320331-wtxja5i9	24	8	only	only	RB
cord-320331-wtxja5i9	24	9	the	the	DT
cord-320331-wtxja5i9	24	10	studies	study	NNS
cord-320331-wtxja5i9	24	11	which	which	WDT
cord-320331-wtxja5i9	24	12	investigated	investigate	VBD
cord-320331-wtxja5i9	24	13	the	the	DT
cord-320331-wtxja5i9	24	14	effects	effect	NNS
cord-320331-wtxja5i9	24	15	of	of	IN
cord-320331-wtxja5i9	24	16	anti	anti	JJ
cord-320331-wtxja5i9	24	17	-	-	JJ
cord-320331-wtxja5i9	24	18	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	24	19	drugs	drug	NNS
cord-320331-wtxja5i9	24	20	or	or	CC
cord-320331-wtxja5i9	24	21	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	24	22	on	on	IN
cord-320331-wtxja5i9	24	23	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	24	24	,	,	,
cord-320331-wtxja5i9	24	25	using	use	VBG
cord-320331-wtxja5i9	24	26	additional	additional	JJ
cord-320331-wtxja5i9	24	27	terms	term	NNS
cord-320331-wtxja5i9	24	28	for	for	IN
cord-320331-wtxja5i9	24	29	the	the	DT
cord-320331-wtxja5i9	24	30	string	string	NN
cord-320331-wtxja5i9	24	31	such	such	JJ
cord-320331-wtxja5i9	24	32	as	as	IN
cord-320331-wtxja5i9	24	33	'	'	``
cord-320331-wtxja5i9	24	34	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	24	35	'	'	''
cord-320331-wtxja5i9	24	36	,	,	,
cord-320331-wtxja5i9	24	37	'	'	``
cord-320331-wtxja5i9	24	38	NSAID	NSAID	NNP
cord-320331-wtxja5i9	24	39	'	'	''
cord-320331-wtxja5i9	24	40	,	,	,
cord-320331-wtxja5i9	24	41	'	'	``
cord-320331-wtxja5i9	24	42	steroids	steroid	NNS
cord-320331-wtxja5i9	24	43	'	'	''
cord-320331-wtxja5i9	24	44	,	,	,
cord-320331-wtxja5i9	24	45	'	'	''
cord-320331-wtxja5i9	24	46	anti	anti	JJ
cord-320331-wtxja5i9	24	47	-	-	JJ
cord-320331-wtxja5i9	24	48	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	24	49	'	'	''
cord-320331-wtxja5i9	24	50	or	or	CC
cord-320331-wtxja5i9	24	51	'	'	``
cord-320331-wtxja5i9	24	52	inflammation	inflammation	NN
cord-320331-wtxja5i9	24	53	'	'	''
cord-320331-wtxja5i9	24	54	,	,	,
cord-320331-wtxja5i9	24	55	and	and	CC
cord-320331-wtxja5i9	24	56	by	by	IN
cord-320331-wtxja5i9	24	57	narrowing	narrow	VBG
cord-320331-wtxja5i9	24	58	the	the	DT
cord-320331-wtxja5i9	24	59	publication	publication	NN
cord-320331-wtxja5i9	24	60	type	type	NN
cord-320331-wtxja5i9	24	61	to	to	IN
cord-320331-wtxja5i9	24	62	'	'	''
cord-320331-wtxja5i9	24	63	Journal	Journal	NNP
cord-320331-wtxja5i9	24	64	article	article	NN
cord-320331-wtxja5i9	24	65	'	'	''
cord-320331-wtxja5i9	24	66	,	,	,
cord-320331-wtxja5i9	24	67	'	'	''
cord-320331-wtxja5i9	24	68	Clinical	clinical	JJ
cord-320331-wtxja5i9	24	69	trial	trial	NN
cord-320331-wtxja5i9	24	70	'	'	''
cord-320331-wtxja5i9	24	71	,	,	,
cord-320331-wtxja5i9	24	72	'	'	``
cord-320331-wtxja5i9	24	73	review	review	NN
cord-320331-wtxja5i9	24	74	'	'	''
cord-320331-wtxja5i9	24	75	,	,	,
cord-320331-wtxja5i9	24	76	'	'	''
cord-320331-wtxja5i9	24	77	systematic	systematic	JJ
cord-320331-wtxja5i9	24	78	review	review	NN
cord-320331-wtxja5i9	24	79	'	'	''
cord-320331-wtxja5i9	24	80	,	,	,
cord-320331-wtxja5i9	24	81	'	'	''
cord-320331-wtxja5i9	24	82	meta	meta	NNP
cord-320331-wtxja5i9	24	83	-	-	HYPH
cord-320331-wtxja5i9	24	84	analysis	analysis	NNP
cord-320331-wtxja5i9	24	85	'	'	''
cord-320331-wtxja5i9	24	86	,	,	,
cord-320331-wtxja5i9	24	87	or	or	CC
cord-320331-wtxja5i9	24	88	'	'	``
cord-320331-wtxja5i9	24	89	randomized	randomize	VBN
cord-320331-wtxja5i9	24	90	controlled	control	VBN
cord-320331-wtxja5i9	24	91	trial	trial	NN
cord-320331-wtxja5i9	24	92	'	'	''
cord-320331-wtxja5i9	24	93	.	.	.
cord-320331-wtxja5i9	25	1	We	-PRON-	PRP
cord-320331-wtxja5i9	25	2	then	then	RB
cord-320331-wtxja5i9	25	3	analyzed	analyze	VBD
cord-320331-wtxja5i9	25	4	each	each	DT
cord-320331-wtxja5i9	25	5	article	article	NN
cord-320331-wtxja5i9	25	6	to	to	TO
cord-320331-wtxja5i9	25	7	include	include	VB
cord-320331-wtxja5i9	25	8	only	only	RB
cord-320331-wtxja5i9	25	9	those	those	DT
cord-320331-wtxja5i9	25	10	that	that	WDT
cord-320331-wtxja5i9	25	11	proposed	propose	VBD
cord-320331-wtxja5i9	25	12	either	either	CC
cord-320331-wtxja5i9	25	13	the	the	DT
cord-320331-wtxja5i9	25	14	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	25	15	of	of	IN
cord-320331-wtxja5i9	25	16	action	action	NN
cord-320331-wtxja5i9	25	17	of	of	IN
cord-320331-wtxja5i9	25	18	SARS	SARS	NNP
cord-320331-wtxja5i9	25	19	-	-	HYPH
cord-320331-wtxja5i9	25	20	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	25	21	on	on	IN
cord-320331-wtxja5i9	25	22	the	the	DT
cord-320331-wtxja5i9	25	23	RAAS	raa	NNS
cord-320331-wtxja5i9	25	24	or	or	CC
cord-320331-wtxja5i9	25	25	of	of	IN
cord-320331-wtxja5i9	25	26	the	the	DT
cord-320331-wtxja5i9	25	27	drugs	drug	NNS
cord-320331-wtxja5i9	25	28	that	that	WDT
cord-320331-wtxja5i9	25	29	interact	interact	VBP
cord-320331-wtxja5i9	25	30	with	with	IN
cord-320331-wtxja5i9	25	31	SARS	SARS	NNP
cord-320331-wtxja5i9	25	32	-	-	HYPH
cord-320331-wtxja5i9	25	33	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	25	34	or	or	CC
cord-320331-wtxja5i9	25	35	the	the	DT
cord-320331-wtxja5i9	25	36	RAAS	raa	NNS
cord-320331-wtxja5i9	25	37	,	,	,
cord-320331-wtxja5i9	25	38	to	to	IN
cord-320331-wtxja5i9	25	39	a	a	DT
cord-320331-wtxja5i9	25	40	final	final	JJ
cord-320331-wtxja5i9	25	41	count	count	NN
cord-320331-wtxja5i9	25	42	of	of	IN
cord-320331-wtxja5i9	25	43	63	63	CD
cord-320331-wtxja5i9	25	44	.	.	.
cord-320331-wtxja5i9	26	1	From	from	IN
cord-320331-wtxja5i9	26	2	the	the	DT
cord-320331-wtxja5i9	26	3	following	follow	VBG
cord-320331-wtxja5i9	26	4	studies	study	NNS
cord-320331-wtxja5i9	26	5	,	,	,
cord-320331-wtxja5i9	26	6	all	all	DT
cord-320331-wtxja5i9	26	7	journal	journal	NN
cord-320331-wtxja5i9	26	8	articles	article	NNS
cord-320331-wtxja5i9	26	9	,	,	,
cord-320331-wtxja5i9	26	10	clinical	clinical	JJ
cord-320331-wtxja5i9	26	11	trials	trial	NNS
cord-320331-wtxja5i9	26	12	,	,	,
cord-320331-wtxja5i9	26	13	systematic	systematic	JJ
cord-320331-wtxja5i9	26	14	reviews	review	NNS
cord-320331-wtxja5i9	26	15	and	and	CC
cord-320331-wtxja5i9	26	16	meta	meta	NNP
cord-320331-wtxja5i9	26	17	-	-	HYPH
cord-320331-wtxja5i9	26	18	analyses	analysis	NNS
cord-320331-wtxja5i9	26	19	,	,	,
cord-320331-wtxja5i9	26	20	excluding	exclude	VBG
cord-320331-wtxja5i9	26	21	literature	literature	NN
cord-320331-wtxja5i9	26	22	reviews	review	NNS
cord-320331-wtxja5i9	26	23	,	,	,
cord-320331-wtxja5i9	26	24	were	be	VBD
cord-320331-wtxja5i9	26	25	included	include	VBN
cord-320331-wtxja5i9	26	26	only	only	RB
cord-320331-wtxja5i9	26	27	if	if	IN
cord-320331-wtxja5i9	26	28	they	-PRON-	PRP
cord-320331-wtxja5i9	26	29	provided	provide	VBD
cord-320331-wtxja5i9	26	30	experimental	experimental	JJ
cord-320331-wtxja5i9	26	31	or	or	CC
cord-320331-wtxja5i9	26	32	clinical	clinical	JJ
cord-320331-wtxja5i9	26	33	evidence	evidence	NN
cord-320331-wtxja5i9	26	34	,	,	,
cord-320331-wtxja5i9	26	35	which	which	WDT
cord-320331-wtxja5i9	26	36	narrowed	narrow	VBD
cord-320331-wtxja5i9	26	37	the	the	DT
cord-320331-wtxja5i9	26	38	inclusion	inclusion	NN
cord-320331-wtxja5i9	26	39	to	to	IN
cord-320331-wtxja5i9	26	40	five	five	CD
cord-320331-wtxja5i9	26	41	articles	article	NNS
cord-320331-wtxja5i9	26	42	(	(	-LRB-
cord-320331-wtxja5i9	26	43	two	two	CD
cord-320331-wtxja5i9	26	44	retrospective	retrospective	JJ
cord-320331-wtxja5i9	26	45	cohort	cohort	NN
cord-320331-wtxja5i9	26	46	studies	study	NNS
cord-320331-wtxja5i9	26	47	,	,	,
cord-320331-wtxja5i9	26	48	one	one	CD
cord-320331-wtxja5i9	26	49	case	case	NN
cord-320331-wtxja5i9	26	50	series	series	NN
cord-320331-wtxja5i9	26	51	,	,	,
cord-320331-wtxja5i9	26	52	one	one	CD
cord-320331-wtxja5i9	26	53	in	in	IN
cord-320331-wtxja5i9	26	54	silico	silico	NN
cord-320331-wtxja5i9	26	55	analysis	analysis	NN
cord-320331-wtxja5i9	26	56	,	,	,
cord-320331-wtxja5i9	26	57	and	and	CC
cord-320331-wtxja5i9	26	58	one	one	CD
cord-320331-wtxja5i9	26	59	in	in	IN
cord-320331-wtxja5i9	26	60	vitro	vitro	FW
cord-320331-wtxja5i9	26	61	study	study	NN
cord-320331-wtxja5i9	26	62	)	)	-RRB-
cord-320331-wtxja5i9	26	63	.	.	.
cord-320331-wtxja5i9	27	1	A	a	DT
cord-320331-wtxja5i9	27	2	second	second	JJ
cord-320331-wtxja5i9	27	3	,	,	,
cord-320331-wtxja5i9	27	4	less	less	RBR
cord-320331-wtxja5i9	27	5	-	-	HYPH
cord-320331-wtxja5i9	27	6	stringent	stringent	JJ
cord-320331-wtxja5i9	27	7	search	search	NN
cord-320331-wtxja5i9	27	8	was	be	VBD
cord-320331-wtxja5i9	27	9	done	do	VBN
cord-320331-wtxja5i9	27	10	which	which	WDT
cord-320331-wtxja5i9	27	11	included	include	VBD
cord-320331-wtxja5i9	27	12	studies	study	NNS
cord-320331-wtxja5i9	27	13	on	on	IN
cord-320331-wtxja5i9	27	14	anti	anti	JJ
cord-320331-wtxja5i9	27	15	-	-	JJ
cord-320331-wtxja5i9	27	16	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	27	17	or	or	CC
cord-320331-wtxja5i9	27	18	corticosteroid	corticosteroid	JJ
cord-320331-wtxja5i9	27	19	drug	drug	NN
cord-320331-wtxja5i9	27	20	use	use	NN
cord-320331-wtxja5i9	27	21	for	for	IN
cord-320331-wtxja5i9	27	22	COVID-19	covid-19	NN
cord-320331-wtxja5i9	27	23	with	with	IN
cord-320331-wtxja5i9	27	24	or	or	CC
cord-320331-wtxja5i9	27	25	without	without	IN
cord-320331-wtxja5i9	27	26	associations	association	NNS
cord-320331-wtxja5i9	27	27	to	to	IN
cord-320331-wtxja5i9	27	28	the	the	DT
cord-320331-wtxja5i9	27	29	RAAS	raa	NNS
cord-320331-wtxja5i9	27	30	,	,	,
cord-320331-wtxja5i9	27	31	using	use	VBG
cord-320331-wtxja5i9	27	32	the	the	DT
cord-320331-wtxja5i9	27	33	similar	similar	JJ
cord-320331-wtxja5i9	27	34	terms	term	NNS
cord-320331-wtxja5i9	27	35	as	as	IN
cord-320331-wtxja5i9	27	36	mentioned	mention	VBN
cord-320331-wtxja5i9	27	37	above	above	RB
cord-320331-wtxja5i9	27	38	.	.	.
cord-320331-wtxja5i9	28	1	This	this	DT
cord-320331-wtxja5i9	28	2	search	search	NN
cord-320331-wtxja5i9	28	3	returned	return	VBD
cord-320331-wtxja5i9	28	4	seven	seven	CD
cord-320331-wtxja5i9	28	5	studies	study	NNS
cord-320331-wtxja5i9	28	6	which	which	WDT
cord-320331-wtxja5i9	28	7	were	be	VBD
cord-320331-wtxja5i9	28	8	either	either	DT
cord-320331-wtxja5i9	28	9	systematic	systematic	JJ
cord-320331-wtxja5i9	28	10	reviews	review	NNS
cord-320331-wtxja5i9	28	11	or	or	CC
cord-320331-wtxja5i9	28	12	meta	meta	NNP
cord-320331-wtxja5i9	28	13	-	-	HYPH
cord-320331-wtxja5i9	28	14	analyses	analysis	NNS
cord-320331-wtxja5i9	28	15	or	or	CC
cord-320331-wtxja5i9	28	16	both	both	DT
cord-320331-wtxja5i9	28	17	,	,	,
cord-320331-wtxja5i9	28	18	and	and	CC
cord-320331-wtxja5i9	28	19	were	be	VBD
cord-320331-wtxja5i9	28	20	included	include	VBN
cord-320331-wtxja5i9	28	21	in	in	IN
cord-320331-wtxja5i9	28	22	this	this	DT
cord-320331-wtxja5i9	28	23	review	review	NN
cord-320331-wtxja5i9	28	24	(	(	-LRB-
cord-320331-wtxja5i9	28	25	Supplementary	Supplementary	NNP
cord-320331-wtxja5i9	28	26	File	File	NNP
cord-320331-wtxja5i9	28	27	1	1	CD
cord-320331-wtxja5i9	28	28	)	)	-RRB-
cord-320331-wtxja5i9	28	29	.	.	.
cord-320331-wtxja5i9	29	1	For	for	IN
cord-320331-wtxja5i9	29	2	the	the	DT
cord-320331-wtxja5i9	29	3	said	say	VBN
cord-320331-wtxja5i9	29	4	searches	search	NNS
cord-320331-wtxja5i9	29	5	,	,	,
cord-320331-wtxja5i9	29	6	we	-PRON-	PRP
cord-320331-wtxja5i9	29	7	considered	consider	VBD
cord-320331-wtxja5i9	29	8	articles	article	NNS
cord-320331-wtxja5i9	29	9	that	that	WDT
cord-320331-wtxja5i9	29	10	are	be	VBP
cord-320331-wtxja5i9	29	11	not	not	RB
cord-320331-wtxja5i9	29	12	only	only	RB
cord-320331-wtxja5i9	29	13	in	in	IN
cord-320331-wtxja5i9	29	14	the	the	DT
cord-320331-wtxja5i9	29	15	English	english	JJ
cord-320331-wtxja5i9	29	16	language	language	NN
cord-320331-wtxja5i9	29	17	,	,	,
cord-320331-wtxja5i9	29	18	but	but	CC
cord-320331-wtxja5i9	29	19	also	also	RB
cord-320331-wtxja5i9	29	20	those	those	DT
cord-320331-wtxja5i9	29	21	written	write	VBN
cord-320331-wtxja5i9	29	22	in	in	IN
cord-320331-wtxja5i9	29	23	Chinese	Chinese	NNP
cord-320331-wtxja5i9	29	24	,	,	,
cord-320331-wtxja5i9	29	25	Dutch	dutch	JJ
cord-320331-wtxja5i9	29	26	,	,	,
cord-320331-wtxja5i9	29	27	French	french	JJ
cord-320331-wtxja5i9	29	28	and	and	CC
cord-320331-wtxja5i9	29	29	Russian	russian	JJ
cord-320331-wtxja5i9	29	30	.	.	.
cord-320331-wtxja5i9	30	1	The	the	DT
cord-320331-wtxja5i9	30	2	two	two	CD
cord-320331-wtxja5i9	30	3	literature	literature	NN
cord-320331-wtxja5i9	30	4	searches	search	NNS
cord-320331-wtxja5i9	30	5	were	be	VBD
cord-320331-wtxja5i9	30	6	accomplished	accomplish	VBN
cord-320331-wtxja5i9	30	7	on	on	IN
cord-320331-wtxja5i9	30	8	August	August	NNP
cord-320331-wtxja5i9	30	9	6	6	CD
cord-320331-wtxja5i9	30	10	.	.	.
cord-320331-wtxja5i9	31	1	On	on	IN
cord-320331-wtxja5i9	31	2	the	the	DT
cord-320331-wtxja5i9	31	3	other	other	JJ
cord-320331-wtxja5i9	31	4	hand	hand	NN
cord-320331-wtxja5i9	31	5	,	,	,
cord-320331-wtxja5i9	31	6	we	-PRON-	PRP
cord-320331-wtxja5i9	31	7	included	include	VBD
cord-320331-wtxja5i9	31	8	studies	study	NNS
cord-320331-wtxja5i9	31	9	on	on	IN
cord-320331-wtxja5i9	31	10	the	the	DT
cord-320331-wtxja5i9	31	11	epidemiology	epidemiology	NN
cord-320331-wtxja5i9	31	12	of	of	IN
cord-320331-wtxja5i9	31	13	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	31	14	and	and	CC
cord-320331-wtxja5i9	31	15	the	the	DT
cord-320331-wtxja5i9	31	16	molecular	molecular	JJ
cord-320331-wtxja5i9	31	17	biology	biology	NN
cord-320331-wtxja5i9	31	18	of	of	IN
cord-320331-wtxja5i9	31	19	SARS	SARS	NNP
cord-320331-wtxja5i9	31	20	-	-	HYPH
cord-320331-wtxja5i9	31	21	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	32	1	based	base	VBN
cord-320331-wtxja5i9	32	2	on	on	IN
cord-320331-wtxja5i9	32	3	chronology	chronology	NN
cord-320331-wtxja5i9	32	4	to	to	TO
cord-320331-wtxja5i9	32	5	reflect	reflect	VB
cord-320331-wtxja5i9	32	6	the	the	DT
cord-320331-wtxja5i9	32	7	turn	turn	NN
cord-320331-wtxja5i9	32	8	of	of	IN
cord-320331-wtxja5i9	32	9	events	event	NNS
cord-320331-wtxja5i9	32	10	during	during	IN
cord-320331-wtxja5i9	32	11	the	the	DT
cord-320331-wtxja5i9	32	12	pandemic	pandemic	NN
cord-320331-wtxja5i9	32	13	.	.	.
cord-320331-wtxja5i9	33	1	For	for	IN
cord-320331-wtxja5i9	33	2	most	most	JJS
cord-320331-wtxja5i9	33	3	of	of	IN
cord-320331-wtxja5i9	33	4	the	the	DT
cord-320331-wtxja5i9	33	5	review	review	NN
cord-320331-wtxja5i9	33	6	,	,	,
cord-320331-wtxja5i9	33	7	basic	basic	JJ
cord-320331-wtxja5i9	33	8	science	science	NN
cord-320331-wtxja5i9	33	9	researches	research	NNS
cord-320331-wtxja5i9	33	10	that	that	WDT
cord-320331-wtxja5i9	33	11	explain	explain	VBP
cord-320331-wtxja5i9	33	12	or	or	CC
cord-320331-wtxja5i9	33	13	complete	complete	VB
cord-320331-wtxja5i9	33	14	mechanistic	mechanistic	JJ
cord-320331-wtxja5i9	33	15	pathways	pathway	NNS
cord-320331-wtxja5i9	33	16	on	on	IN
cord-320331-wtxja5i9	33	17	the	the	DT
cord-320331-wtxja5i9	33	18	physiology	physiology	NN
cord-320331-wtxja5i9	33	19	and	and	CC
cord-320331-wtxja5i9	33	20	biology	biology	NN
cord-320331-wtxja5i9	33	21	of	of	IN
cord-320331-wtxja5i9	33	22	the	the	DT
cord-320331-wtxja5i9	33	23	RAAS	raa	NNS
cord-320331-wtxja5i9	33	24	or	or	CC
cord-320331-wtxja5i9	33	25	of	of	IN
cord-320331-wtxja5i9	33	26	the	the	DT
cord-320331-wtxja5i9	33	27	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	33	28	of	of	IN
cord-320331-wtxja5i9	33	29	anti	anti	JJ
cord-320331-wtxja5i9	33	30	-	-	JJ
cord-320331-wtxja5i9	33	31	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	33	32	drugs	drug	NNS
cord-320331-wtxja5i9	33	33	and	and	CC
cord-320331-wtxja5i9	33	34	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	33	35	were	be	VBD
cord-320331-wtxja5i9	33	36	referenced	reference	VBN
cord-320331-wtxja5i9	33	37	from	from	IN
cord-320331-wtxja5i9	33	38	PubMed	PubMed	NNP
cord-320331-wtxja5i9	33	39	and	and	CC
cord-320331-wtxja5i9	33	40	Google	Google	NNP
cord-320331-wtxja5i9	33	41	Scholar	Scholar	NNP
cord-320331-wtxja5i9	33	42	at	at	IN
cord-320331-wtxja5i9	33	43	our	-PRON-	PRP$
cord-320331-wtxja5i9	33	44	discretion	discretion	NN
cord-320331-wtxja5i9	33	45	.	.	.
cord-320331-wtxja5i9	34	1	In	in	IN
cord-320331-wtxja5i9	34	2	addition	addition	NN
cord-320331-wtxja5i9	34	3	,	,	,
cord-320331-wtxja5i9	34	4	pertinent	pertinent	JJ
cord-320331-wtxja5i9	34	5	references	reference	NNS
cord-320331-wtxja5i9	34	6	J	J	NNP
cord-320331-wtxja5i9	34	7	o	o	NN
cord-320331-wtxja5i9	34	8	u	u	NN
cord-320331-wtxja5i9	34	9	r	r	NN
cord-320331-wtxja5i9	34	10	n	n	NN
cord-320331-wtxja5i9	34	11	a	a	DT
cord-320331-wtxja5i9	34	12	l	l	NN
cord-320331-wtxja5i9	34	13	P	p	NN
cord-320331-wtxja5i9	34	14	r	r	NN
cord-320331-wtxja5i9	34	15	e	e	NN
cord-320331-wtxja5i9	34	16	-p	-p	NN
cord-320331-wtxja5i9	35	1	r	r	NNP
cord-320331-wtxja5i9	35	2	o	o	NN
cord-320331-wtxja5i9	35	3	o	o	NN
cord-320331-wtxja5i9	35	4	f	f	NN
cord-320331-wtxja5i9	35	5	suggested	suggest	VBN
cord-320331-wtxja5i9	35	6	by	by	IN
cord-320331-wtxja5i9	35	7	the	the	DT
cord-320331-wtxja5i9	35	8	reviewers	reviewer	NNS
cord-320331-wtxja5i9	35	9	were	be	VBD
cord-320331-wtxja5i9	35	10	included	include	VBN
cord-320331-wtxja5i9	35	11	as	as	IN
cord-320331-wtxja5i9	35	12	needed	need	VBN
cord-320331-wtxja5i9	35	13	,	,	,
cord-320331-wtxja5i9	35	14	especially	especially	RB
cord-320331-wtxja5i9	35	15	those	those	DT
cord-320331-wtxja5i9	35	16	that	that	WDT
cord-320331-wtxja5i9	35	17	were	be	VBD
cord-320331-wtxja5i9	35	18	not	not	RB
cord-320331-wtxja5i9	35	19	covered	cover	VBN
cord-320331-wtxja5i9	35	20	at	at	IN
cord-320331-wtxja5i9	35	21	the	the	DT
cord-320331-wtxja5i9	35	22	time	time	NN
cord-320331-wtxja5i9	35	23	of	of	IN
cord-320331-wtxja5i9	35	24	the	the	DT
cord-320331-wtxja5i9	35	25	literature	literature	NN
cord-320331-wtxja5i9	35	26	search	search	NN
cord-320331-wtxja5i9	35	27	.	.	.
cord-320331-wtxja5i9	36	1	It	-PRON-	PRP
cord-320331-wtxja5i9	36	2	is	be	VBZ
cord-320331-wtxja5i9	36	3	important	important	JJ
cord-320331-wtxja5i9	36	4	to	to	TO
cord-320331-wtxja5i9	36	5	note	note	VB
cord-320331-wtxja5i9	36	6	that	that	IN
cord-320331-wtxja5i9	36	7	since	since	IN
cord-320331-wtxja5i9	36	8	the	the	DT
cord-320331-wtxja5i9	36	9	approach	approach	NN
cord-320331-wtxja5i9	36	10	of	of	IN
cord-320331-wtxja5i9	36	11	this	this	DT
cord-320331-wtxja5i9	36	12	paper	paper	NN
cord-320331-wtxja5i9	36	13	is	be	VBZ
cord-320331-wtxja5i9	36	14	to	to	TO
cord-320331-wtxja5i9	36	15	provide	provide	VB
cord-320331-wtxja5i9	36	16	current	current	JJ
cord-320331-wtxja5i9	36	17	knowledge	knowledge	NN
cord-320331-wtxja5i9	36	18	on	on	IN
cord-320331-wtxja5i9	36	19	the	the	DT
cord-320331-wtxja5i9	36	20	anatomic	anatomic	JJ
cord-320331-wtxja5i9	36	21	,	,	,
cord-320331-wtxja5i9	36	22	physiologic	physiologic	JJ
cord-320331-wtxja5i9	36	23	and	and	CC
cord-320331-wtxja5i9	36	24	molecular	molecular	JJ
cord-320331-wtxja5i9	36	25	bases	basis	NNS
cord-320331-wtxja5i9	36	26	of	of	IN
cord-320331-wtxja5i9	36	27	anti	anti	JJ
cord-320331-wtxja5i9	36	28	-	-	JJ
cord-320331-wtxja5i9	36	29	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	36	30	drug	drug	NN
cord-320331-wtxja5i9	36	31	and	and	CC
cord-320331-wtxja5i9	36	32	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	36	33	action	action	NN
cord-320331-wtxja5i9	36	34	on	on	IN
cord-320331-wtxja5i9	36	35	the	the	DT
cord-320331-wtxja5i9	36	36	RAAS	raa	NNS
cord-320331-wtxja5i9	36	37	,	,	,
cord-320331-wtxja5i9	36	38	this	this	DT
cord-320331-wtxja5i9	36	39	paper	paper	NN
cord-320331-wtxja5i9	36	40	will	will	MD
cord-320331-wtxja5i9	36	41	not	not	RB
cord-320331-wtxja5i9	36	42	demonstrate	demonstrate	VB
cord-320331-wtxja5i9	36	43	a	a	DT
cord-320331-wtxja5i9	36	44	systematic	systematic	JJ
cord-320331-wtxja5i9	36	45	review	review	NN
cord-320331-wtxja5i9	36	46	or	or	CC
cord-320331-wtxja5i9	36	47	meta	meta	NN
cord-320331-wtxja5i9	36	48	-	-	HYPH
cord-320331-wtxja5i9	36	49	analysis	analysis	NN
cord-320331-wtxja5i9	36	50	of	of	IN
cord-320331-wtxja5i9	36	51	current	current	JJ
cord-320331-wtxja5i9	36	52	clinical	clinical	JJ
cord-320331-wtxja5i9	36	53	evidence	evidence	NN
cord-320331-wtxja5i9	36	54	,	,	,
cord-320331-wtxja5i9	36	55	but	but	CC
cord-320331-wtxja5i9	36	56	will	will	MD
cord-320331-wtxja5i9	36	57	only	only	RB
cord-320331-wtxja5i9	36	58	provide	provide	VB
cord-320331-wtxja5i9	36	59	insight	insight	NN
cord-320331-wtxja5i9	36	60	on	on	IN
cord-320331-wtxja5i9	36	61	the	the	DT
cord-320331-wtxja5i9	36	62	probable	probable	JJ
cord-320331-wtxja5i9	36	63	influences	influence	NNS
cord-320331-wtxja5i9	36	64	of	of	IN
cord-320331-wtxja5i9	36	65	the	the	DT
cord-320331-wtxja5i9	36	66	discussed	discuss	VBN
cord-320331-wtxja5i9	36	67	pathways	pathway	NNS
cord-320331-wtxja5i9	36	68	on	on	IN
cord-320331-wtxja5i9	36	69	early	early	JJ
cord-320331-wtxja5i9	36	70	SARS	SARS	NNP
cord-320331-wtxja5i9	36	71	-	-	HYPH
cord-320331-wtxja5i9	36	72	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	36	73	infection	infection	NN
cord-320331-wtxja5i9	36	74	.	.	.
cord-320331-wtxja5i9	37	1	Further	further	RB
cord-320331-wtxja5i9	37	2	,	,	,
cord-320331-wtxja5i9	37	3	since	since	IN
cord-320331-wtxja5i9	37	4	there	there	EX
cord-320331-wtxja5i9	37	5	is	be	VBZ
cord-320331-wtxja5i9	37	6	a	a	DT
cord-320331-wtxja5i9	37	7	present	present	JJ
cord-320331-wtxja5i9	37	8	lack	lack	NN
cord-320331-wtxja5i9	37	9	of	of	IN
cord-320331-wtxja5i9	37	10	definitive	definitive	JJ
cord-320331-wtxja5i9	37	11	studies	study	NNS
cord-320331-wtxja5i9	37	12	investigating	investigate	VBG
cord-320331-wtxja5i9	37	13	the	the	DT
cord-320331-wtxja5i9	37	14	association	association	NN
cord-320331-wtxja5i9	37	15	between	between	IN
cord-320331-wtxja5i9	37	16	NSAID	NSAID	NNP
cord-320331-wtxja5i9	37	17	or	or	CC
cord-320331-wtxja5i9	37	18	corticosteroid	corticosteroid	JJ
cord-320331-wtxja5i9	37	19	drug	drug	NN
cord-320331-wtxja5i9	37	20	use	use	NN
cord-320331-wtxja5i9	37	21	and	and	CC
cord-320331-wtxja5i9	37	22	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	37	23	outcome	outcome	NN
cord-320331-wtxja5i9	37	24	severity	severity	NN
cord-320331-wtxja5i9	37	25	,	,	,
cord-320331-wtxja5i9	37	26	such	such	JJ
cord-320331-wtxja5i9	37	27	clinical	clinical	JJ
cord-320331-wtxja5i9	37	28	analyses	analysis	NNS
cord-320331-wtxja5i9	37	29	are	be	VBP
cord-320331-wtxja5i9	37	30	only	only	RB
cord-320331-wtxja5i9	37	31	warranted	warrant	VBN
cord-320331-wtxja5i9	37	32	as	as	IN
cord-320331-wtxja5i9	37	33	more	more	JJR
cord-320331-wtxja5i9	37	34	evidence	evidence	NN
cord-320331-wtxja5i9	37	35	is	be	VBZ
cord-320331-wtxja5i9	37	36	obtained	obtain	VBN
cord-320331-wtxja5i9	37	37	.	.	.
cord-320331-wtxja5i9	38	1	In	in	IN
cord-320331-wtxja5i9	38	2	late	late	JJ
cord-320331-wtxja5i9	38	3	of	of	IN
cord-320331-wtxja5i9	38	4	December	December	NNP
cord-320331-wtxja5i9	38	5	2019	2019	CD
cord-320331-wtxja5i9	38	6	,	,	,
cord-320331-wtxja5i9	38	7	Dr.	Dr.	NNP
cord-320331-wtxja5i9	38	8	Wang	Wang	NNP
cord-320331-wtxja5i9	38	9	and	and	CC
cord-320331-wtxja5i9	38	10	researchers	researcher	NNS
cord-320331-wtxja5i9	38	11	from	from	IN
cord-320331-wtxja5i9	38	12	the	the	DT
cord-320331-wtxja5i9	38	13	Institute	Institute	NNP
cord-320331-wtxja5i9	38	14	of	of	IN
cord-320331-wtxja5i9	38	15	Pathogen	Pathogen	NNP
cord-320331-wtxja5i9	38	16	Biology	Biology	NNP
cord-320331-wtxja5i9	38	17	in	in	IN
cord-320331-wtxja5i9	38	18	China	China	NNP
cord-320331-wtxja5i9	38	19	obtained	obtain	VBD
cord-320331-wtxja5i9	38	20	the	the	DT
cord-320331-wtxja5i9	38	21	complete	complete	JJ
cord-320331-wtxja5i9	38	22	sequence	sequence	NN
cord-320331-wtxja5i9	38	23	of	of	IN
cord-320331-wtxja5i9	38	24	SARS	SARS	NNP
cord-320331-wtxja5i9	38	25	-	-	HYPH
cord-320331-wtxja5i9	38	26	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	38	27	from	from	IN
cord-320331-wtxja5i9	38	28	bronchoalveolar	bronchoalveolar	NNP
cord-320331-wtxja5i9	38	29	lavage	lavage	NN
cord-320331-wtxja5i9	38	30	specimens	specimen	NNS
cord-320331-wtxja5i9	38	31	of	of	IN
cord-320331-wtxja5i9	38	32	patients	patient	NNS
cord-320331-wtxja5i9	38	33	in	in	IN
cord-320331-wtxja5i9	38	34	Wuhan	Wuhan	NNP
cord-320331-wtxja5i9	38	35	presenting	present	VBG
cord-320331-wtxja5i9	38	36	with	with	IN
cord-320331-wtxja5i9	38	37	acute	acute	JJ
cord-320331-wtxja5i9	38	38	respiratory	respiratory	JJ
cord-320331-wtxja5i9	38	39	distress	distress	NN
cord-320331-wtxja5i9	38	40	syndrome	syndrome	NN
cord-320331-wtxja5i9	38	41	(	(	-LRB-
cord-320331-wtxja5i9	38	42	ARDS	ARDS	NNP
cord-320331-wtxja5i9	38	43	)	)	-RRB-
cord-320331-wtxja5i9	38	44	[	[	-LRB-
cord-320331-wtxja5i9	38	45	7	7	CD
cord-320331-wtxja5i9	38	46	]	]	-RRB-
cord-320331-wtxja5i9	38	47	.	.	.
cord-320331-wtxja5i9	39	1	A	a	DT
cord-320331-wtxja5i9	39	2	subsequent	subsequent	JJ
cord-320331-wtxja5i9	39	3	study	study	NN
cord-320331-wtxja5i9	39	4	then	then	RB
cord-320331-wtxja5i9	39	5	extracted	extract	VBD
cord-320331-wtxja5i9	39	6	SARS	SARS	NNP
cord-320331-wtxja5i9	39	7	-	-	HYPH
cord-320331-wtxja5i9	39	8	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	39	9	DNA	dna	NN
cord-320331-wtxja5i9	39	10	from	from	IN
cord-320331-wtxja5i9	39	11	nine	nine	CD
cord-320331-wtxja5i9	39	12	patients	patient	NNS
cord-320331-wtxja5i9	39	13	with	with	IN
cord-320331-wtxja5i9	39	14	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	39	15	,	,	,
cord-320331-wtxja5i9	39	16	which	which	WDT
cord-320331-wtxja5i9	39	17	found	find	VBD
cord-320331-wtxja5i9	39	18	a	a	DT
cord-320331-wtxja5i9	39	19	79	79	CD
cord-320331-wtxja5i9	39	20	%	%	NN
cord-320331-wtxja5i9	39	21	and	and	CC
cord-320331-wtxja5i9	39	22	50	50	CD
cord-320331-wtxja5i9	39	23	%	%	NN
cord-320331-wtxja5i9	39	24	identity	identity	NN
cord-320331-wtxja5i9	39	25	with	with	IN
cord-320331-wtxja5i9	39	26	SARS	SARS	NNP
cord-320331-wtxja5i9	39	27	-	-	HYPH
cord-320331-wtxja5i9	39	28	CoV	CoV	NNP
cord-320331-wtxja5i9	39	29	and	and	CC
cord-320331-wtxja5i9	39	30	MERS	MERS	NNP
cord-320331-wtxja5i9	39	31	-	-	HYPH
cord-320331-wtxja5i9	39	32	CoV	CoV	NNP
cord-320331-wtxja5i9	39	33	,	,	,
cord-320331-wtxja5i9	39	34	respectively	respectively	RB
cord-320331-wtxja5i9	39	35	[	[	-LRB-
cord-320331-wtxja5i9	39	36	8	8	CD
cord-320331-wtxja5i9	39	37	]	]	-RRB-
cord-320331-wtxja5i9	39	38	.	.	.
cord-320331-wtxja5i9	40	1	Similarly	similarly	RB
cord-320331-wtxja5i9	40	2	,	,	,
cord-320331-wtxja5i9	40	3	another	another	DT
cord-320331-wtxja5i9	40	4	study	study	NN
cord-320331-wtxja5i9	40	5	reported	report	VBD
cord-320331-wtxja5i9	40	6	an	an	DT
cord-320331-wtxja5i9	40	7	86	86	CD
cord-320331-wtxja5i9	40	8	%	%	NN
cord-320331-wtxja5i9	40	9	similarity	similarity	NN
cord-320331-wtxja5i9	40	10	between	between	IN
cord-320331-wtxja5i9	40	11	the	the	DT
cord-320331-wtxja5i9	40	12	SARS	SARS	NNP
cord-320331-wtxja5i9	40	13	-	-	HYPH
cord-320331-wtxja5i9	40	14	CoV	CoV	NNP
cord-320331-wtxja5i9	40	15	and	and	CC
cord-320331-wtxja5i9	40	16	SARS	SARS	NNP
cord-320331-wtxja5i9	40	17	-	-	HYPH
cord-320331-wtxja5i9	40	18	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	40	19	genomic	genomic	JJ
cord-320331-wtxja5i9	40	20	sequences	sequence	NNS
cord-320331-wtxja5i9	40	21	,	,	,
cord-320331-wtxja5i9	40	22	with	with	IN
cord-320331-wtxja5i9	40	23	high	high	JJ
cord-320331-wtxja5i9	40	24	degrees	degree	NNS
cord-320331-wtxja5i9	40	25	of	of	IN
cord-320331-wtxja5i9	40	26	homology	homology	NN
cord-320331-wtxja5i9	40	27	to	to	IN
cord-320331-wtxja5i9	40	28	the	the	DT
cord-320331-wtxja5i9	40	29	SARS	SARS	NNP
cord-320331-wtxja5i9	40	30	-	-	HYPH
cord-320331-wtxja5i9	40	31	like	like	JJ
cord-320331-wtxja5i9	40	32	coronaviruses	coronaviruse	NNS
cord-320331-wtxja5i9	40	33	isolated	isolate	VBN
cord-320331-wtxja5i9	40	34	from	from	IN
cord-320331-wtxja5i9	40	35	bats	bat	NNS
cord-320331-wtxja5i9	40	36	[	[	-LRB-
cord-320331-wtxja5i9	40	37	9	9	CD
cord-320331-wtxja5i9	40	38	]	]	-RRB-
cord-320331-wtxja5i9	40	39	.	.	.
cord-320331-wtxja5i9	41	1	Since	since	IN
cord-320331-wtxja5i9	41	2	SARS	SARS	NNP
cord-320331-wtxja5i9	41	3	-	-	HYPH
cord-320331-wtxja5i9	41	4	CoV	CoV	NNP
cord-320331-wtxja5i9	41	5	was	be	VBD
cord-320331-wtxja5i9	41	6	known	know	VBN
cord-320331-wtxja5i9	41	7	to	to	TO
cord-320331-wtxja5i9	41	8	bind	bind	VB
cord-320331-wtxja5i9	41	9	to	to	IN
cord-320331-wtxja5i9	41	10	human	human	JJ
cord-320331-wtxja5i9	41	11	angiotensinconverting	angiotensinconverting	NN
cord-320331-wtxja5i9	41	12	enzyme	enzyme	NN
cord-320331-wtxja5i9	41	13	2	2	CD
cord-320331-wtxja5i9	41	14	(	(	-LRB-
cord-320331-wtxja5i9	41	15	ACE2	ACE2	NNP
cord-320331-wtxja5i9	41	16	)	)	-RRB-
cord-320331-wtxja5i9	41	17	for	for	IN
cord-320331-wtxja5i9	41	18	viral	viral	JJ
cord-320331-wtxja5i9	41	19	entry	entry	NN
cord-320331-wtxja5i9	41	20	,	,	,
cord-320331-wtxja5i9	41	21	these	these	DT
cord-320331-wtxja5i9	41	22	data	datum	NNS
cord-320331-wtxja5i9	41	23	suggested	suggest	VBD
cord-320331-wtxja5i9	41	24	that	that	IN
cord-320331-wtxja5i9	41	25	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	41	26	may	may	MD
cord-320331-wtxja5i9	41	27	also	also	RB
cord-320331-wtxja5i9	41	28	utilize	utilize	VB
cord-320331-wtxja5i9	41	29	its	-PRON-	PRP$
cord-320331-wtxja5i9	41	30	high	high	JJ
cord-320331-wtxja5i9	41	31	affinity	affinity	NN
cord-320331-wtxja5i9	41	32	binding	bind	VBG
cord-320331-wtxja5i9	41	33	for	for	IN
cord-320331-wtxja5i9	41	34	human	human	JJ
cord-320331-wtxja5i9	41	35	ACE2	ACE2	NNP
cord-320331-wtxja5i9	41	36	to	to	TO
cord-320331-wtxja5i9	41	37	enter	enter	VB
cord-320331-wtxja5i9	41	38	host	host	NN
cord-320331-wtxja5i9	41	39	cells	cell	NNS
cord-320331-wtxja5i9	41	40	,	,	,
cord-320331-wtxja5i9	41	41	by	by	IN
cord-320331-wtxja5i9	41	42	virtue	virtue	NN
cord-320331-wtxja5i9	41	43	of	of	IN
cord-320331-wtxja5i9	41	44	its	-PRON-	PRP$
cord-320331-wtxja5i9	41	45	conserved	conserved	JJ
cord-320331-wtxja5i9	41	46	receptor	receptor	NN
cord-320331-wtxja5i9	41	47	binding	bind	VBG
cord-320331-wtxja5i9	41	48	domain	domain	NN
cord-320331-wtxja5i9	41	49	(	(	-LRB-
cord-320331-wtxja5i9	41	50	RBD	RBD	NNP
cord-320331-wtxja5i9	41	51	)	)	-RRB-
cord-320331-wtxja5i9	41	52	,	,	,
cord-320331-wtxja5i9	41	53	which	which	WDT
cord-320331-wtxja5i9	41	54	was	be	VBD
cord-320331-wtxja5i9	41	55	later	later	RB
cord-320331-wtxja5i9	41	56	confirmed	confirm	VBN
cord-320331-wtxja5i9	41	57	to	to	TO
cord-320331-wtxja5i9	41	58	be	be	VB
cord-320331-wtxja5i9	41	59	true	true	JJ
cord-320331-wtxja5i9	41	60	[	[	-LRB-
cord-320331-wtxja5i9	41	61	9	9	CD
cord-320331-wtxja5i9	41	62	,	,	,
cord-320331-wtxja5i9	41	63	10	10	CD
cord-320331-wtxja5i9	41	64	,	,	,
cord-320331-wtxja5i9	41	65	11	11	CD
cord-320331-wtxja5i9	41	66	]	]	-RRB-
cord-320331-wtxja5i9	41	67	.	.	.
cord-320331-wtxja5i9	42	1	In	in	IN
cord-320331-wtxja5i9	42	2	2017	2017	CD
cord-320331-wtxja5i9	42	3	,	,	,
cord-320331-wtxja5i9	42	4	Khan	Khan	NNP
cord-320331-wtxja5i9	42	5	et	et	NNP
cord-320331-wtxja5i9	42	6	.	.	.
cord-320331-wtxja5i9	43	1	al	al	NNP
cord-320331-wtxja5i9	43	2	.	.	NNP
cord-320331-wtxja5i9	43	3	developed	develop	VBD
cord-320331-wtxja5i9	43	4	a	a	DT
cord-320331-wtxja5i9	43	5	pilot	pilot	NN
cord-320331-wtxja5i9	43	6	clinical	clinical	JJ
cord-320331-wtxja5i9	43	7	trial	trial	NN
cord-320331-wtxja5i9	43	8	using	use	VBG
cord-320331-wtxja5i9	43	9	human	human	JJ
cord-320331-wtxja5i9	43	10	recombinant	recombinant	NN
cord-320331-wtxja5i9	43	11	soluble	soluble	JJ
cord-320331-wtxja5i9	43	12	ACE2	ACE2	NNP
cord-320331-wtxja5i9	43	13	,	,	,
cord-320331-wtxja5i9	43	14	also	also	RB
cord-320331-wtxja5i9	43	15	known	know	VBN
cord-320331-wtxja5i9	43	16	as	as	IN
cord-320331-wtxja5i9	43	17	GSK2586881	GSK2586881	NNP
cord-320331-wtxja5i9	43	18	,	,	,
cord-320331-wtxja5i9	43	19	as	as	IN
cord-320331-wtxja5i9	43	20	a	a	DT
cord-320331-wtxja5i9	43	21	potential	potential	JJ
cord-320331-wtxja5i9	43	22	treatment	treatment	NN
cord-320331-wtxja5i9	43	23	for	for	IN
cord-320331-wtxja5i9	43	24	acute	acute	JJ
cord-320331-wtxja5i9	43	25	lung	lung	NN
cord-320331-wtxja5i9	43	26	injury	injury	NN
cord-320331-wtxja5i9	43	27	.	.	.
cord-320331-wtxja5i9	44	1	The	the	DT
cord-320331-wtxja5i9	44	2	two	two	CD
cord-320331-wtxja5i9	44	3	-	-	HYPH
cord-320331-wtxja5i9	44	4	part	part	NN
cord-320331-wtxja5i9	44	5	clinical	clinical	JJ
cord-320331-wtxja5i9	44	6	trial	trial	NN
cord-320331-wtxja5i9	44	7	,	,	,
cord-320331-wtxja5i9	44	8	although	although	IN
cord-320331-wtxja5i9	44	9	showed	show	VBD
cord-320331-wtxja5i9	44	10	a	a	DT
cord-320331-wtxja5i9	44	11	successful	successful	JJ
cord-320331-wtxja5i9	44	12	interaction	interaction	NN
cord-320331-wtxja5i9	44	13	of	of	IN
cord-320331-wtxja5i9	44	14	hrsACE2	hrsACE2	NNP
cord-320331-wtxja5i9	44	15	and	and	CC
cord-320331-wtxja5i9	44	16	its	-PRON-	PRP$
cord-320331-wtxja5i9	44	17	targets	target	NNS
cord-320331-wtxja5i9	44	18	by	by	IN
cord-320331-wtxja5i9	44	19	evaluating	evaluate	VBG
cord-320331-wtxja5i9	44	20	the	the	DT
cord-320331-wtxja5i9	44	21	modulation	modulation	NN
cord-320331-wtxja5i9	44	22	of	of	IN
cord-320331-wtxja5i9	44	23	RAS	RAS	NNP
cord-320331-wtxja5i9	44	24	,	,	,
cord-320331-wtxja5i9	44	25	did	do	VBD
cord-320331-wtxja5i9	44	26	not	not	RB
cord-320331-wtxja5i9	44	27	elaborate	elaborate	VB
cord-320331-wtxja5i9	44	28	any	any	DT
cord-320331-wtxja5i9	44	29	clinical	clinical	JJ
cord-320331-wtxja5i9	44	30	changes	change	NNS
cord-320331-wtxja5i9	44	31	or	or	CC
cord-320331-wtxja5i9	44	32	improvements	improvement	NNS
cord-320331-wtxja5i9	45	1	J	J	NNP
cord-320331-wtxja5i9	45	2	o	o	NN
cord-320331-wtxja5i9	45	3	u	u	NN
cord-320331-wtxja5i9	45	4	r	r	NN
cord-320331-wtxja5i9	45	5	n	n	NN
cord-320331-wtxja5i9	45	6	a	a	DT
cord-320331-wtxja5i9	45	7	l	l	NN
cord-320331-wtxja5i9	45	8	P	p	NN
cord-320331-wtxja5i9	45	9	r	r	NN
cord-320331-wtxja5i9	45	10	e	e	NN
cord-320331-wtxja5i9	45	11	-p	-p	NN
cord-320331-wtxja5i9	45	12	r	r	NN
cord-320331-wtxja5i9	46	1	o	o	UH
cord-320331-wtxja5i9	46	2	o	o	NN
cord-320331-wtxja5i9	46	3	f	f	NN
cord-320331-wtxja5i9	46	4	upon	upon	IN
cord-320331-wtxja5i9	46	5	administration	administration	NN
cord-320331-wtxja5i9	46	6	of	of	IN
cord-320331-wtxja5i9	46	7	GSK2586881	GSK2586881	NNP
cord-320331-wtxja5i9	46	8	[	[	-LRB-
cord-320331-wtxja5i9	46	9	73	73	CD
cord-320331-wtxja5i9	46	10	]	]	-RRB-
cord-320331-wtxja5i9	46	11	.	.	.
cord-320331-wtxja5i9	47	1	It	-PRON-	PRP
cord-320331-wtxja5i9	47	2	did	do	VBD
cord-320331-wtxja5i9	47	3	,	,	,
cord-320331-wtxja5i9	47	4	however	however	RB
cord-320331-wtxja5i9	47	5	show	show	VB
cord-320331-wtxja5i9	47	6	an	an	DT
cord-320331-wtxja5i9	47	7	increase	increase	NN
cord-320331-wtxja5i9	47	8	in	in	IN
cord-320331-wtxja5i9	47	9	Ang(1	Ang(1	NNP
cord-320331-wtxja5i9	47	10	-	-	HYPH
cord-320331-wtxja5i9	47	11	7	7	CD
cord-320331-wtxja5i9	47	12	)	)	-RRB-
cord-320331-wtxja5i9	47	13	synthesis	synthesis	NN
cord-320331-wtxja5i9	47	14	from	from	IN
cord-320331-wtxja5i9	47	15	Ang	Ang	NNP
cord-320331-wtxja5i9	47	16	II	II	NNP
cord-320331-wtxja5i9	47	17	,	,	,
cord-320331-wtxja5i9	47	18	offering	offer	VBG
cord-320331-wtxja5i9	47	19	protection	protection	NN
cord-320331-wtxja5i9	47	20	against	against	IN
cord-320331-wtxja5i9	47	21	heart	heart	NN
cord-320331-wtxja5i9	47	22	failure	failure	NN
cord-320331-wtxja5i9	47	23	with	with	IN
cord-320331-wtxja5i9	47	24	reduced	reduce	VBN
cord-320331-wtxja5i9	47	25	and	and	CC
cord-320331-wtxja5i9	47	26	preserved	preserve	VBN
cord-320331-wtxja5i9	47	27	ejection	ejection	NN
cord-320331-wtxja5i9	47	28	fraction	fraction	NN
cord-320331-wtxja5i9	47	29	largely	largely	RB
cord-320331-wtxja5i9	47	30	due	due	JJ
cord-320331-wtxja5i9	47	31	to	to	IN
cord-320331-wtxja5i9	47	32	ACE2	ACE2	NNP
cord-320331-wtxja5i9	47	33	deficiency	deficiency	NN
cord-320331-wtxja5i9	47	34	,	,	,
cord-320331-wtxja5i9	47	35	as	as	RB
cord-320331-wtxja5i9	47	36	well	well	RB
cord-320331-wtxja5i9	47	37	as	as	IN
cord-320331-wtxja5i9	47	38	preventing	prevent	VBG
cord-320331-wtxja5i9	47	39	Ang	Ang	NNP
cord-320331-wtxja5i9	47	40	II	II	NNP
cord-320331-wtxja5i9	47	41	-	-	HYPH
cord-320331-wtxja5i9	47	42	induced	induce	VBN
cord-320331-wtxja5i9	47	43	myocardial	myocardial	JJ
cord-320331-wtxja5i9	47	44	hypertrophy	hypertrophy	NN
cord-320331-wtxja5i9	47	45	,	,	,
cord-320331-wtxja5i9	47	46	diastolic	diastolic	JJ
cord-320331-wtxja5i9	47	47	dysfunction	dysfunction	NN
cord-320331-wtxja5i9	47	48	,	,	,
cord-320331-wtxja5i9	47	49	and	and	CC
cord-320331-wtxja5i9	47	50	myocardial	myocardial	JJ
cord-320331-wtxja5i9	47	51	fibrosis	fibrosis	NN
cord-320331-wtxja5i9	47	52	[	[	-LRB-
cord-320331-wtxja5i9	47	53	74	74	CD
cord-320331-wtxja5i9	47	54	,	,	,
cord-320331-wtxja5i9	47	55	75	75	CD
cord-320331-wtxja5i9	47	56	]	]	-RRB-
cord-320331-wtxja5i9	47	57	.	.	.
cord-320331-wtxja5i9	48	1	Earlier	early	RBR
cord-320331-wtxja5i9	48	2	this	this	DT
cord-320331-wtxja5i9	48	3	year	year	NN
cord-320331-wtxja5i9	48	4	,	,	,
cord-320331-wtxja5i9	48	5	Monteil	Monteil	NNP
cord-320331-wtxja5i9	48	6	et	et	NNP
cord-320331-wtxja5i9	48	7	.	.	.
cord-320331-wtxja5i9	49	1	al	al	NNP
cord-320331-wtxja5i9	49	2	did	do	VBD
cord-320331-wtxja5i9	49	3	a	a	DT
cord-320331-wtxja5i9	49	4	similar	similar	JJ
cord-320331-wtxja5i9	49	5	study	study	NN
cord-320331-wtxja5i9	49	6	where	where	WRB
cord-320331-wtxja5i9	49	7	they	-PRON-	PRP
cord-320331-wtxja5i9	49	8	engineered	engineer	VBD
cord-320331-wtxja5i9	49	9	human	human	JJ
cord-320331-wtxja5i9	49	10	blood	blood	NN
cord-320331-wtxja5i9	49	11	vessel	vessel	NN
cord-320331-wtxja5i9	49	12	organoids	organoid	NNS
cord-320331-wtxja5i9	49	13	and	and	CC
cord-320331-wtxja5i9	49	14	human	human	JJ
cord-320331-wtxja5i9	49	15	kidney	kidney	NN
cord-320331-wtxja5i9	49	16	organoids	organoid	NNS
cord-320331-wtxja5i9	49	17	,	,	,
cord-320331-wtxja5i9	49	18	both	both	DT
cord-320331-wtxja5i9	49	19	of	of	IN
cord-320331-wtxja5i9	49	20	which	which	WDT
cord-320331-wtxja5i9	49	21	expressed	express	VBD
cord-320331-wtxja5i9	49	22	a	a	DT
cord-320331-wtxja5i9	49	23	sufficient	sufficient	JJ
cord-320331-wtxja5i9	49	24	amount	amount	NN
cord-320331-wtxja5i9	49	25	of	of	IN
cord-320331-wtxja5i9	49	26	ACE2	ACE2	NNP
cord-320331-wtxja5i9	49	27	,	,	,
cord-320331-wtxja5i9	49	28	to	to	TO
cord-320331-wtxja5i9	49	29	emulate	emulate	VB
cord-320331-wtxja5i9	49	30	SARS	SARS	NNP
cord-320331-wtxja5i9	49	31	-	-	HYPH
cord-320331-wtxja5i9	49	32	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	49	33	infection	infection	NN
cord-320331-wtxja5i9	49	34	in	in	IN
cord-320331-wtxja5i9	49	35	human	human	JJ
cord-320331-wtxja5i9	49	36	tissues	tissue	NNS
cord-320331-wtxja5i9	49	37	and	and	CC
cord-320331-wtxja5i9	49	38	organs	organ	NNS
cord-320331-wtxja5i9	49	39	.	.	.
cord-320331-wtxja5i9	50	1	This	this	DT
cord-320331-wtxja5i9	50	2	idea	idea	NN
cord-320331-wtxja5i9	50	3	was	be	VBD
cord-320331-wtxja5i9	50	4	built	build	VBN
cord-320331-wtxja5i9	50	5	on	on	IN
cord-320331-wtxja5i9	50	6	the	the	DT
cord-320331-wtxja5i9	50	7	knowledge	knowledge	NN
cord-320331-wtxja5i9	50	8	that	that	WDT
cord-320331-wtxja5i9	50	9	SARS	SARS	NNP
cord-320331-wtxja5i9	50	10	-	-	HYPH
cord-320331-wtxja5i9	50	11	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	50	12	mainly	mainly	RB
cord-320331-wtxja5i9	50	13	uses	use	VBZ
cord-320331-wtxja5i9	50	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	50	15	as	as	IN
cord-320331-wtxja5i9	50	16	the	the	DT
cord-320331-wtxja5i9	50	17	entry	entry	NN
cord-320331-wtxja5i9	50	18	point	point	NN
cord-320331-wtxja5i9	50	19	into	into	IN
cord-320331-wtxja5i9	50	20	cellular	cellular	JJ
cord-320331-wtxja5i9	50	21	invasion	invasion	NN
cord-320331-wtxja5i9	50	22	.	.	.
cord-320331-wtxja5i9	51	1	By	by	IN
cord-320331-wtxja5i9	51	2	introducing	introduce	VBG
cord-320331-wtxja5i9	51	3	human	human	JJ
cord-320331-wtxja5i9	51	4	recombinant	recombinant	NN
cord-320331-wtxja5i9	51	5	soluble	soluble	JJ
cord-320331-wtxja5i9	51	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	51	7	(	(	-LRB-
cord-320331-wtxja5i9	51	8	hrsACE2	hrsACE2	NNP
cord-320331-wtxja5i9	51	9	)	)	-RRB-
cord-320331-wtxja5i9	51	10	,	,	,
cord-320331-wtxja5i9	51	11	the	the	DT
cord-320331-wtxja5i9	51	12	S	S	NNP
cord-320331-wtxja5i9	51	13	-	-	HYPH
cord-320331-wtxja5i9	51	14	protein	protein	NN
cord-320331-wtxja5i9	51	15	region	region	NN
cord-320331-wtxja5i9	51	16	of	of	IN
cord-320331-wtxja5i9	51	17	SARS	SARS	NNP
cord-320331-wtxja5i9	51	18	-	-	HYPH
cord-320331-wtxja5i9	51	19	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	51	20	was	be	VBD
cord-320331-wtxja5i9	51	21	competitively	competitively	RB
cord-320331-wtxja5i9	51	22	bound	bind	VBN
cord-320331-wtxja5i9	51	23	by	by	IN
cord-320331-wtxja5i9	51	24	the	the	DT
cord-320331-wtxja5i9	51	25	enzyme	enzyme	NN
cord-320331-wtxja5i9	51	26	,	,	,
cord-320331-wtxja5i9	51	27	which	which	WDT
cord-320331-wtxja5i9	51	28	effectively	effectively	RB
cord-320331-wtxja5i9	51	29	limited	limit	VBD
cord-320331-wtxja5i9	51	30	the	the	DT
cord-320331-wtxja5i9	51	31	binding	binding	NN
cord-320331-wtxja5i9	51	32	and	and	CC
cord-320331-wtxja5i9	51	33	entry	entry	NN
cord-320331-wtxja5i9	51	34	of	of	IN
cord-320331-wtxja5i9	51	35	SARS	SARS	NNP
cord-320331-wtxja5i9	51	36	-	-	:
cord-320331-wtxja5i9	51	37	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	51	38	thereby	thereby	RB
cord-320331-wtxja5i9	51	39	preventing	prevent	VBG
cord-320331-wtxja5i9	51	40	infection	infection	NN
cord-320331-wtxja5i9	51	41	in	in	IN
cord-320331-wtxja5i9	51	42	a	a	DT
cord-320331-wtxja5i9	51	43	dose	dose	NN
cord-320331-wtxja5i9	51	44	-	-	HYPH
cord-320331-wtxja5i9	51	45	dependent	dependent	JJ
cord-320331-wtxja5i9	51	46	manner	manner	NN
cord-320331-wtxja5i9	51	47	[	[	-LRB-
cord-320331-wtxja5i9	51	48	76	76	CD
cord-320331-wtxja5i9	51	49	]	]	-RRB-
cord-320331-wtxja5i9	51	50	.	.	.
cord-320331-wtxja5i9	52	1	Several	several	JJ
cord-320331-wtxja5i9	52	2	more	more	JJR
cord-320331-wtxja5i9	52	3	clinical	clinical	JJ
cord-320331-wtxja5i9	52	4	trials	trial	NNS
cord-320331-wtxja5i9	52	5	emerged	emerge	VBD
cord-320331-wtxja5i9	52	6	which	which	WDT
cord-320331-wtxja5i9	52	7	suggested	suggest	VBD
cord-320331-wtxja5i9	52	8	the	the	DT
cord-320331-wtxja5i9	52	9	importance	importance	NN
cord-320331-wtxja5i9	52	10	of	of	IN
cord-320331-wtxja5i9	52	11	hACE2	hace2	NN
cord-320331-wtxja5i9	52	12	to	to	IN
cord-320331-wtxja5i9	52	13	SARS	SARS	NNP
cord-320331-wtxja5i9	52	14	-	-	HYPH
cord-320331-wtxja5i9	52	15	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	52	16	infection	infection	NN
cord-320331-wtxja5i9	52	17	,	,	,
cord-320331-wtxja5i9	52	18	and	and	CC
cord-320331-wtxja5i9	52	19	which	which	WDT
cord-320331-wtxja5i9	52	20	led	lead	VBD
cord-320331-wtxja5i9	52	21	hrsACE2	hrsACE2	NNP
cord-320331-wtxja5i9	52	22	to	to	TO
cord-320331-wtxja5i9	52	23	become	become	VB
cord-320331-wtxja5i9	52	24	one	one	CD
cord-320331-wtxja5i9	52	25	of	of	IN
cord-320331-wtxja5i9	52	26	most	most	RBS
cord-320331-wtxja5i9	52	27	promising	promising	JJ
cord-320331-wtxja5i9	52	28	therapeutics	therapeutic	NNS
cord-320331-wtxja5i9	52	29	for	for	IN
cord-320331-wtxja5i9	52	30	the	the	DT
cord-320331-wtxja5i9	52	31	early	early	JJ
cord-320331-wtxja5i9	52	32	prevention	prevention	NN
cord-320331-wtxja5i9	52	33	of	of	IN
cord-320331-wtxja5i9	52	34	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	52	35	to	to	IN
cord-320331-wtxja5i9	52	36	date	date	NN
cord-320331-wtxja5i9	52	37	.	.	.
cord-320331-wtxja5i9	53	1	There	there	EX
cord-320331-wtxja5i9	53	2	were	be	VBD
cord-320331-wtxja5i9	53	3	six	six	CD
cord-320331-wtxja5i9	53	4	amino	amino	NN
cord-320331-wtxja5i9	53	5	acids	acid	NNS
cord-320331-wtxja5i9	53	6	identified	identify	VBN
cord-320331-wtxja5i9	53	7	in	in	IN
cord-320331-wtxja5i9	53	8	the	the	DT
cord-320331-wtxja5i9	53	9	RBD	RBD	NNP
cord-320331-wtxja5i9	53	10	that	that	WDT
cord-320331-wtxja5i9	53	11	is	be	VBZ
cord-320331-wtxja5i9	53	12	crucial	crucial	JJ
cord-320331-wtxja5i9	53	13	for	for	IN
cord-320331-wtxja5i9	53	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	53	15	binding	binding	NN
cord-320331-wtxja5i9	53	16	,	,	,
cord-320331-wtxja5i9	53	17	and	and	CC
cord-320331-wtxja5i9	53	18	while	while	IN
cord-320331-wtxja5i9	53	19	five	five	CD
cord-320331-wtxja5i9	53	20	of	of	IN
cord-320331-wtxja5i9	53	21	these	these	DT
cord-320331-wtxja5i9	53	22	differed	differ	VBN
cord-320331-wtxja5i9	53	23	between	between	IN
cord-320331-wtxja5i9	53	24	SARS	SARS	NNP
cord-320331-wtxja5i9	53	25	-	-	HYPH
cord-320331-wtxja5i9	53	26	CoV	CoV	NNP
cord-320331-wtxja5i9	53	27	and	and	CC
cord-320331-wtxja5i9	53	28	SARS	SARS	NNP
cord-320331-wtxja5i9	53	29	-	-	HYPH
cord-320331-wtxja5i9	53	30	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	53	31	,	,	,
cord-320331-wtxja5i9	53	32	the	the	DT
cord-320331-wtxja5i9	53	33	binding	bind	VBG
cord-320331-wtxja5i9	53	34	affinity	affinity	NN
cord-320331-wtxja5i9	53	35	of	of	IN
cord-320331-wtxja5i9	53	36	SARS	SARS	NNP
cord-320331-wtxja5i9	53	37	-	-	HYPH
cord-320331-wtxja5i9	53	38	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	53	39	RBD	RBD	NNP
cord-320331-wtxja5i9	53	40	to	to	IN
cord-320331-wtxja5i9	53	41	human	human	JJ
cord-320331-wtxja5i9	53	42	ACE2	ACE2	NNP
cord-320331-wtxja5i9	53	43	receptors	receptor	NNS
cord-320331-wtxja5i9	53	44	was	be	VBD
cord-320331-wtxja5i9	53	45	found	find	VBN
cord-320331-wtxja5i9	53	46	to	to	TO
cord-320331-wtxja5i9	53	47	be	be	VB
cord-320331-wtxja5i9	53	48	10	10	CD
cord-320331-wtxja5i9	53	49	times	time	NNS
cord-320331-wtxja5i9	53	50	higher	high	JJR
cord-320331-wtxja5i9	53	51	than	than	IN
cord-320331-wtxja5i9	53	52	its	-PRON-	PRP$
cord-320331-wtxja5i9	53	53	counterpart	counterpart	NN
cord-320331-wtxja5i9	53	54	spike	spike	NN
cord-320331-wtxja5i9	53	55	protein	protein	NN
cord-320331-wtxja5i9	53	56	in	in	IN
cord-320331-wtxja5i9	53	57	SARS	SARS	NNP
cord-320331-wtxja5i9	53	58	-	-	HYPH
cord-320331-wtxja5i9	53	59	CoV	CoV	NNP
cord-320331-wtxja5i9	53	60	[	[	-LRB-
cord-320331-wtxja5i9	53	61	12	12	CD
cord-320331-wtxja5i9	53	62	,	,	,
cord-320331-wtxja5i9	53	63	69	69	CD
cord-320331-wtxja5i9	53	64	]	]	-RRB-
cord-320331-wtxja5i9	53	65	)	)	-RRB-
cord-320331-wtxja5i9	53	66	.	.	.
cord-320331-wtxja5i9	54	1	This	this	DT
cord-320331-wtxja5i9	54	2	ability	ability	NN
cord-320331-wtxja5i9	54	3	of	of	IN
cord-320331-wtxja5i9	54	4	SARS	SARS	NNP
cord-320331-wtxja5i9	54	5	-	-	HYPH
cord-320331-wtxja5i9	54	6	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	54	7	to	to	TO
cord-320331-wtxja5i9	54	8	bind	bind	VB
cord-320331-wtxja5i9	54	9	the	the	DT
cord-320331-wtxja5i9	54	10	ACE2	ACE2	NNP
cord-320331-wtxja5i9	54	11	enzyme	enzyme	NN
cord-320331-wtxja5i9	54	12	with	with	IN
cord-320331-wtxja5i9	54	13	a	a	DT
cord-320331-wtxja5i9	54	14	stronger	strong	JJR
cord-320331-wtxja5i9	54	15	affinity	affinity	NN
cord-320331-wtxja5i9	54	16	than	than	IN
cord-320331-wtxja5i9	54	17	SARS	SARS	NNP
cord-320331-wtxja5i9	54	18	-	-	HYPH
cord-320331-wtxja5i9	54	19	CoV	CoV	NNP
cord-320331-wtxja5i9	54	20	and	and	CC
cord-320331-wtxja5i9	54	21	HCoV	HCoV	NNP
cord-320331-wtxja5i9	54	22	-	-	HYPH
cord-320331-wtxja5i9	54	23	NL63	NL63	NNP
cord-320331-wtxja5i9	54	24	under	under	IN
cord-320331-wtxja5i9	54	25	a	a	DT
cord-320331-wtxja5i9	54	26	non	non	JJ
cord-320331-wtxja5i9	54	27	-	-	JJ
cord-320331-wtxja5i9	54	28	ideal	ideal	JJ
cord-320331-wtxja5i9	54	29	configuration	configuration	NN
cord-320331-wtxja5i9	54	30	strongly	strongly	RB
cord-320331-wtxja5i9	54	31	implies	imply	VBZ
cord-320331-wtxja5i9	54	32	that	that	IN
cord-320331-wtxja5i9	54	33	prior	prior	JJ
cord-320331-wtxja5i9	54	34	mutations	mutation	NNS
cord-320331-wtxja5i9	54	35	have	have	VBP
cord-320331-wtxja5i9	54	36	been	be	VBN
cord-320331-wtxja5i9	54	37	occurring	occur	VBG
cord-320331-wtxja5i9	54	38	as	as	IN
cord-320331-wtxja5i9	54	39	a	a	DT
cord-320331-wtxja5i9	54	40	form	form	NN
cord-320331-wtxja5i9	54	41	of	of	IN
cord-320331-wtxja5i9	54	42	natural	natural	JJ
cord-320331-wtxja5i9	54	43	selection	selection	NN
cord-320331-wtxja5i9	54	44	.	.	.
cord-320331-wtxja5i9	55	1	That	that	RB
cord-320331-wtxja5i9	55	2	is	is	RB
cord-320331-wtxja5i9	55	3	,	,	,
cord-320331-wtxja5i9	55	4	SARS	SARS	NNP
cord-320331-wtxja5i9	55	5	-	-	HYPH
cord-320331-wtxja5i9	55	6	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	55	7	may	may	MD
cord-320331-wtxja5i9	55	8	have	have	VB
cord-320331-wtxja5i9	55	9	been	be	VBN
cord-320331-wtxja5i9	55	10	circulating	circulate	VBG
cord-320331-wtxja5i9	55	11	the	the	DT
cord-320331-wtxja5i9	55	12	wet	wet	JJ
cord-320331-wtxja5i9	55	13	animal	animal	NN
cord-320331-wtxja5i9	55	14	markets	market	NNS
cord-320331-wtxja5i9	55	15	for	for	IN
cord-320331-wtxja5i9	55	16	several	several	JJ
cord-320331-wtxja5i9	55	17	years	year	NNS
cord-320331-wtxja5i9	55	18	before	before	IN
cord-320331-wtxja5i9	55	19	the	the	DT
cord-320331-wtxja5i9	55	20	outbreak	outbreak	NN
cord-320331-wtxja5i9	55	21	and	and	CC
cord-320331-wtxja5i9	55	22	infecting	infect	VBG
cord-320331-wtxja5i9	55	23	individuals	individual	NNS
cord-320331-wtxja5i9	55	24	without	without	IN
cord-320331-wtxja5i9	55	25	triggering	trigger	VBG
cord-320331-wtxja5i9	55	26	any	any	DT
cord-320331-wtxja5i9	55	27	symptoms	symptom	NNS
cord-320331-wtxja5i9	55	28	[	[	-LRB-
cord-320331-wtxja5i9	55	29	12	12	CD
cord-320331-wtxja5i9	55	30	,	,	,
cord-320331-wtxja5i9	55	31	13	13	CD
cord-320331-wtxja5i9	55	32	]	]	-RRB-
cord-320331-wtxja5i9	55	33	.	.	.
cord-320331-wtxja5i9	56	1	The	the	DT
cord-320331-wtxja5i9	56	2	downstream	downstream	JJ
cord-320331-wtxja5i9	56	3	effect	effect	NN
cord-320331-wtxja5i9	56	4	of	of	IN
cord-320331-wtxja5i9	56	5	the	the	DT
cord-320331-wtxja5i9	56	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	56	7	ligand	ligand	NN
cord-320331-wtxja5i9	56	8	-	-	HYPH
cord-320331-wtxja5i9	56	9	receptor	receptor	NN
cord-320331-wtxja5i9	56	10	complex	complex	NN
cord-320331-wtxja5i9	56	11	is	be	VBZ
cord-320331-wtxja5i9	56	12	the	the	DT
cord-320331-wtxja5i9	56	13	degradation	degradation	NN
cord-320331-wtxja5i9	56	14	of	of	IN
cord-320331-wtxja5i9	56	15	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	56	16	II	II	NNP
cord-320331-wtxja5i9	56	17	(	(	-LRB-
cord-320331-wtxja5i9	56	18	Ang	Ang	NNP
cord-320331-wtxja5i9	56	19	II	II	NNP
cord-320331-wtxja5i9	56	20	)	)	-RRB-
cord-320331-wtxja5i9	56	21	to	to	TO
cord-320331-wtxja5i9	56	22	produce	produce	VB
cord-320331-wtxja5i9	56	23	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	56	24	(	(	-LRB-
cord-320331-wtxja5i9	56	25	1	1	CD
cord-320331-wtxja5i9	56	26	-	-	SYM
cord-320331-wtxja5i9	56	27	7	7	CD
cord-320331-wtxja5i9	56	28	)	)	-RRB-
cord-320331-wtxja5i9	56	29	,	,	,
cord-320331-wtxja5i9	56	30	initiating	initiate	VBG
cord-320331-wtxja5i9	56	31	a	a	DT
cord-320331-wtxja5i9	56	32	negative	negative	JJ
cord-320331-wtxja5i9	56	33	feedback	feedback	NN
cord-320331-wtxja5i9	56	34	mechanism	mechanism	NN
cord-320331-wtxja5i9	56	35	that	that	WDT
cord-320331-wtxja5i9	56	36	inhibits	inhibit	VBZ
cord-320331-wtxja5i9	56	37	further	further	JJ
cord-320331-wtxja5i9	56	38	production	production	NN
cord-320331-wtxja5i9	56	39	of	of	IN
cord-320331-wtxja5i9	56	40	Ang	Ang	NNP
cord-320331-wtxja5i9	56	41	II	II	NNP
cord-320331-wtxja5i9	56	42	.	.	.
cord-320331-wtxja5i9	57	1	Decreased	Decreased	NNP
cord-320331-wtxja5i9	57	2	Ang	Ang	NNP
cord-320331-wtxja5i9	57	3	II	II	NNP
cord-320331-wtxja5i9	57	4	results	result	NNS
cord-320331-wtxja5i9	57	5	in	in	IN
cord-320331-wtxja5i9	57	6	decreased	decrease	VBN
cord-320331-wtxja5i9	57	7	salt	salt	NN
cord-320331-wtxja5i9	57	8	and	and	CC
cord-320331-wtxja5i9	57	9	water	water	NN
cord-320331-wtxja5i9	57	10	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	57	11	,	,	,
cord-320331-wtxja5i9	57	12	which	which	WDT
cord-320331-wtxja5i9	57	13	lowers	lower	VBZ
cord-320331-wtxja5i9	57	14	blood	blood	NN
cord-320331-wtxja5i9	57	15	pressure	pressure	NN
cord-320331-wtxja5i9	57	16	and	and	CC
cord-320331-wtxja5i9	57	17	vascular	vascular	JJ
cord-320331-wtxja5i9	57	18	tone	tone	NN
cord-320331-wtxja5i9	57	19	,	,	,
cord-320331-wtxja5i9	57	20	and	and	CC
cord-320331-wtxja5i9	57	21	effectively	effectively	RB
cord-320331-wtxja5i9	57	22	prevents	prevent	VBZ
cord-320331-wtxja5i9	57	23	the	the	DT
cord-320331-wtxja5i9	57	24	excessive	excessive	JJ
cord-320331-wtxja5i9	57	25	effects	effect	NNS
cord-320331-wtxja5i9	57	26	of	of	IN
cord-320331-wtxja5i9	57	27	Ang	Ang	NNP
cord-320331-wtxja5i9	57	28	II	II	NNP
cord-320331-wtxja5i9	57	29	[	[	-LRB-
cord-320331-wtxja5i9	57	30	14	14	CD
cord-320331-wtxja5i9	57	31	,	,	,
cord-320331-wtxja5i9	57	32	15	15	CD
cord-320331-wtxja5i9	57	33	]	]	-RRB-
cord-320331-wtxja5i9	57	34	.	.	.
cord-320331-wtxja5i9	58	1	When	when	WRB
cord-320331-wtxja5i9	58	2	the	the	DT
cord-320331-wtxja5i9	58	3	SARS	SARS	NNP
cord-320331-wtxja5i9	58	4	-	-	HYPH
cord-320331-wtxja5i9	58	5	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	58	6	viral	viral	JJ
cord-320331-wtxja5i9	58	7	spike	spike	NN
cord-320331-wtxja5i9	58	8	S	s	NN
cord-320331-wtxja5i9	58	9	protein	protein	NN
cord-320331-wtxja5i9	58	10	binds	bind	VBZ
cord-320331-wtxja5i9	58	11	the	the	DT
cord-320331-wtxja5i9	58	12	human	human	JJ
cord-320331-wtxja5i9	58	13	ACE2	ACE2	NNP
cord-320331-wtxja5i9	58	14	enzyme	enzyme	NN
cord-320331-wtxja5i9	58	15	,	,	,
cord-320331-wtxja5i9	58	16	it	-PRON-	PRP
cord-320331-wtxja5i9	58	17	fuses	fuse	VBZ
cord-320331-wtxja5i9	58	18	with	with	IN
cord-320331-wtxja5i9	58	19	the	the	DT
cord-320331-wtxja5i9	58	20	cell	cell	NN
cord-320331-wtxja5i9	58	21	membrane	membrane	NN
cord-320331-wtxja5i9	58	22	to	to	IN
cord-320331-wtxja5i9	58	23	J	J	NNP
cord-320331-wtxja5i9	58	24	o	o	NN
cord-320331-wtxja5i9	58	25	u	u	NN
cord-320331-wtxja5i9	58	26	r	r	NN
cord-320331-wtxja5i9	58	27	n	n	NN
cord-320331-wtxja5i9	58	28	a	a	DT
cord-320331-wtxja5i9	58	29	l	l	NN
cord-320331-wtxja5i9	58	30	P	p	NN
cord-320331-wtxja5i9	58	31	r	r	NN
cord-320331-wtxja5i9	58	32	e	e	NN
cord-320331-wtxja5i9	58	33	-p	-p	NN
cord-320331-wtxja5i9	59	1	r	r	NN
cord-320331-wtxja5i9	59	2	o	o	NN
cord-320331-wtxja5i9	59	3	o	o	NN
cord-320331-wtxja5i9	59	4	f	f	NN
cord-320331-wtxja5i9	59	5	initiate	initiate	VB
cord-320331-wtxja5i9	59	6	viral	viral	JJ
cord-320331-wtxja5i9	59	7	entry	entry	NN
cord-320331-wtxja5i9	59	8	by	by	IN
cord-320331-wtxja5i9	59	9	activating	activate	VBG
cord-320331-wtxja5i9	59	10	signal	signal	NN
cord-320331-wtxja5i9	59	11	transduction	transduction	NN
cord-320331-wtxja5i9	59	12	pathways	pathway	NNS
cord-320331-wtxja5i9	59	13	,	,	,
cord-320331-wtxja5i9	59	14	resulting	result	VBG
cord-320331-wtxja5i9	59	15	to	to	IN
cord-320331-wtxja5i9	59	16	cell	cell	NN
cord-320331-wtxja5i9	59	17	uptake	uptake	NN
cord-320331-wtxja5i9	59	18	of	of	IN
cord-320331-wtxja5i9	59	19	the	the	DT
cord-320331-wtxja5i9	59	20	virusreceptor	virusreceptor	NN
cord-320331-wtxja5i9	59	21	complex	complex	NN
cord-320331-wtxja5i9	59	22	via	via	IN
cord-320331-wtxja5i9	59	23	a	a	DT
cord-320331-wtxja5i9	59	24	process	process	NN
cord-320331-wtxja5i9	59	25	called	call	VBN
cord-320331-wtxja5i9	59	26	clathrin	clathrin	NN
cord-320331-wtxja5i9	59	27	-	-	HYPH
cord-320331-wtxja5i9	59	28	mediated	mediate	VBN
cord-320331-wtxja5i9	59	29	endocytosis	endocytosis	NN
cord-320331-wtxja5i9	59	30	.	.	.
cord-320331-wtxja5i9	60	1	Moreover	moreover	RB
cord-320331-wtxja5i9	60	2	,	,	,
cord-320331-wtxja5i9	60	3	the	the	DT
cord-320331-wtxja5i9	60	4	S	S	NNP
cord-320331-wtxja5i9	60	5	protein	protein	NN
cord-320331-wtxja5i9	60	6	of	of	IN
cord-320331-wtxja5i9	60	7	SARS	SARS	NNP
cord-320331-wtxja5i9	60	8	-	-	HYPH
cord-320331-wtxja5i9	60	9	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	60	10	possesses	possess	VBZ
cord-320331-wtxja5i9	60	11	an	an	DT
cord-320331-wtxja5i9	60	12	S1	S1	NNP
cord-320331-wtxja5i9	60	13	/	/	SYM
cord-320331-wtxja5i9	60	14	S2	s2	NN
cord-320331-wtxja5i9	60	15	site	site	NN
cord-320331-wtxja5i9	60	16	,	,	,
cord-320331-wtxja5i9	60	17	which	which	WDT
cord-320331-wtxja5i9	60	18	is	be	VBZ
cord-320331-wtxja5i9	60	19	cleaved	cleave	VBN
cord-320331-wtxja5i9	60	20	by	by	IN
cord-320331-wtxja5i9	60	21	furin	furin	NN
cord-320331-wtxja5i9	60	22	,	,	,
cord-320331-wtxja5i9	60	23	to	to	TO
cord-320331-wtxja5i9	60	24	encourage	encourage	VB
cord-320331-wtxja5i9	60	25	entry	entry	NN
cord-320331-wtxja5i9	60	26	of	of	IN
cord-320331-wtxja5i9	60	27	SARS	SARS	NNP
cord-320331-wtxja5i9	60	28	-	-	HYPH
cord-320331-wtxja5i9	60	29	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	60	30	into	into	IN
cord-320331-wtxja5i9	60	31	the	the	DT
cord-320331-wtxja5i9	60	32	cell	cell	NN
cord-320331-wtxja5i9	60	33	while	while	IN
cord-320331-wtxja5i9	60	34	evading	evade	VBG
cord-320331-wtxja5i9	60	35	the	the	DT
cord-320331-wtxja5i9	60	36	host	host	NN
cord-320331-wtxja5i9	60	37	immune	immune	JJ
cord-320331-wtxja5i9	60	38	response	response	NN
cord-320331-wtxja5i9	60	39	[	[	-LRB-
cord-320331-wtxja5i9	60	40	16	16	CD
cord-320331-wtxja5i9	60	41	,	,	,
cord-320331-wtxja5i9	60	42	17	17	CD
cord-320331-wtxja5i9	60	43	,	,	,
cord-320331-wtxja5i9	60	44	18	18	CD
cord-320331-wtxja5i9	60	45	,	,	,
cord-320331-wtxja5i9	60	46	64	64	CD
cord-320331-wtxja5i9	60	47	]	]	-RRB-
cord-320331-wtxja5i9	60	48	.	.	.
cord-320331-wtxja5i9	61	1	In	in	IN
cord-320331-wtxja5i9	61	2	the	the	DT
cord-320331-wtxja5i9	61	3	process	process	NN
cord-320331-wtxja5i9	61	4	,	,	,
cord-320331-wtxja5i9	61	5	ACE2	ACE2	NNP
cord-320331-wtxja5i9	61	6	is	be	VBZ
cord-320331-wtxja5i9	61	7	inhibited	inhibit	VBN
cord-320331-wtxja5i9	61	8	and	and	CC
cord-320331-wtxja5i9	61	9	internalized	internalize	VBN
cord-320331-wtxja5i9	61	10	,	,	,
cord-320331-wtxja5i9	61	11	and	and	CC
cord-320331-wtxja5i9	61	12	reduced	reduce	VBN
cord-320331-wtxja5i9	61	13	membrane	membrane	NN
cord-320331-wtxja5i9	61	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	61	15	affects	affect	VBZ
cord-320331-wtxja5i9	61	16	the	the	DT
cord-320331-wtxja5i9	61	17	homeostasis	homeostasis	NN
cord-320331-wtxja5i9	61	18	of	of	IN
cord-320331-wtxja5i9	61	19	RAAS	raa	NNS
cord-320331-wtxja5i9	61	20	due	due	JJ
cord-320331-wtxja5i9	61	21	to	to	IN
cord-320331-wtxja5i9	61	22	decreased	decrease	VBD
cord-320331-wtxja5i9	61	23	Ang	Ang	NNP
cord-320331-wtxja5i9	61	24	II	II	NNP
cord-320331-wtxja5i9	61	25	breakdown	breakdown	NN
cord-320331-wtxja5i9	61	26	.	.	.
cord-320331-wtxja5i9	62	1	Ang	Ang	NNP
cord-320331-wtxja5i9	62	2	II	II	NNP
cord-320331-wtxja5i9	62	3	is	be	VBZ
cord-320331-wtxja5i9	62	4	a	a	DT
cord-320331-wtxja5i9	62	5	direct	direct	JJ
cord-320331-wtxja5i9	62	6	vasoconstrictor	vasoconstrictor	NN
cord-320331-wtxja5i9	62	7	known	know	VBN
cord-320331-wtxja5i9	62	8	for	for	IN
cord-320331-wtxja5i9	62	9	its	-PRON-	PRP$
cord-320331-wtxja5i9	62	10	predominantly	predominantly	RB
cord-320331-wtxja5i9	62	11	vasoactive	vasoactive	JJ
cord-320331-wtxja5i9	62	12	properties	property	NNS
cord-320331-wtxja5i9	62	13	,	,	,
cord-320331-wtxja5i9	62	14	and	and	CC
cord-320331-wtxja5i9	62	15	its	-PRON-	PRP$
cord-320331-wtxja5i9	62	16	excessive	excessive	JJ
cord-320331-wtxja5i9	62	17	production	production	NN
cord-320331-wtxja5i9	62	18	is	be	VBZ
cord-320331-wtxja5i9	62	19	associated	associate	VBN
cord-320331-wtxja5i9	62	20	with	with	IN
cord-320331-wtxja5i9	62	21	acute	acute	JJ
cord-320331-wtxja5i9	62	22	hemodynamic	hemodynamic	JJ
cord-320331-wtxja5i9	62	23	changes	change	NNS
cord-320331-wtxja5i9	62	24	,	,	,
cord-320331-wtxja5i9	62	25	such	such	JJ
cord-320331-wtxja5i9	62	26	as	as	IN
cord-320331-wtxja5i9	62	27	hypertension	hypertension	NN
cord-320331-wtxja5i9	62	28	and	and	CC
cord-320331-wtxja5i9	62	29	a	a	DT
cord-320331-wtxja5i9	62	30	drop	drop	NN
cord-320331-wtxja5i9	62	31	in	in	IN
cord-320331-wtxja5i9	62	32	glomerular	glomerular	JJ
cord-320331-wtxja5i9	62	33	filtration	filtration	NN
cord-320331-wtxja5i9	62	34	rate	rate	NN
cord-320331-wtxja5i9	62	35	(	(	-LRB-
cord-320331-wtxja5i9	62	36	GFR	GFR	NNP
cord-320331-wtxja5i9	62	37	)	)	-RRB-
cord-320331-wtxja5i9	62	38	.	.	.
cord-320331-wtxja5i9	63	1	This	this	DT
cord-320331-wtxja5i9	63	2	triggers	trigger	VBZ
cord-320331-wtxja5i9	63	3	chronic	chronic	JJ
cord-320331-wtxja5i9	63	4	inflammation	inflammation	NN
cord-320331-wtxja5i9	63	5	if	if	IN
cord-320331-wtxja5i9	63	6	left	leave	VBN
cord-320331-wtxja5i9	63	7	unaddressed	unaddressed	JJ
cord-320331-wtxja5i9	63	8	,	,	,
cord-320331-wtxja5i9	63	9	and	and	CC
cord-320331-wtxja5i9	63	10	eventually	eventually	RB
cord-320331-wtxja5i9	63	11	leads	lead	VBZ
cord-320331-wtxja5i9	63	12	to	to	TO
cord-320331-wtxja5i9	63	13	end	end	VB
cord-320331-wtxja5i9	63	14	-	-	HYPH
cord-320331-wtxja5i9	63	15	organ	organ	NN
cord-320331-wtxja5i9	63	16	failure	failure	NN
cord-320331-wtxja5i9	63	17	due	due	IN
cord-320331-wtxja5i9	63	18	to	to	IN
cord-320331-wtxja5i9	63	19	fibroid	fibroid	NN
cord-320331-wtxja5i9	63	20	formation	formation	NN
cord-320331-wtxja5i9	63	21	[	[	-LRB-
cord-320331-wtxja5i9	63	22	70	70	CD
cord-320331-wtxja5i9	63	23	,	,	,
cord-320331-wtxja5i9	63	24	71	71	CD
cord-320331-wtxja5i9	63	25	,	,	,
cord-320331-wtxja5i9	63	26	72	72	CD
cord-320331-wtxja5i9	63	27	]	]	-RRB-
cord-320331-wtxja5i9	63	28	.	.	.
cord-320331-wtxja5i9	64	1	ACE2	ACE2	NNP
cord-320331-wtxja5i9	64	2	is	be	VBZ
cord-320331-wtxja5i9	64	3	an	an	DT
cord-320331-wtxja5i9	64	4	active	active	JJ
cord-320331-wtxja5i9	64	5	homologue	homologue	NN
cord-320331-wtxja5i9	64	6	of	of	IN
cord-320331-wtxja5i9	64	7	ACE	ACE	NNP
cord-320331-wtxja5i9	64	8	seen	see	VBN
cord-320331-wtxja5i9	64	9	in	in	IN
cord-320331-wtxja5i9	64	10	a	a	DT
cord-320331-wtxja5i9	64	11	diverse	diverse	JJ
cord-320331-wtxja5i9	64	12	group	group	NN
cord-320331-wtxja5i9	64	13	of	of	IN
cord-320331-wtxja5i9	64	14	tissues	tissue	NNS
cord-320331-wtxja5i9	64	15	including	include	VBG
cord-320331-wtxja5i9	64	16	the	the	DT
cord-320331-wtxja5i9	64	17	oral	oral	JJ
cord-320331-wtxja5i9	64	18	and	and	CC
cord-320331-wtxja5i9	64	19	nasal	nasal	JJ
cord-320331-wtxja5i9	64	20	mucosa	mucosa	NN
cord-320331-wtxja5i9	64	21	,	,	,
cord-320331-wtxja5i9	64	22	the	the	DT
cord-320331-wtxja5i9	64	23	lungs	lung	NNS
cord-320331-wtxja5i9	64	24	,	,	,
cord-320331-wtxja5i9	64	25	the	the	DT
cord-320331-wtxja5i9	64	26	gastrointestinal	gastrointestinal	JJ
cord-320331-wtxja5i9	64	27	tract	tract	NN
cord-320331-wtxja5i9	64	28	,	,	,
cord-320331-wtxja5i9	64	29	blood	blood	NN
cord-320331-wtxja5i9	64	30	forming	form	VBG
cord-320331-wtxja5i9	64	31	organs	organ	NNS
cord-320331-wtxja5i9	64	32	,	,	,
cord-320331-wtxja5i9	64	33	liver	liver	NN
cord-320331-wtxja5i9	64	34	,	,	,
cord-320331-wtxja5i9	64	35	kidney	kidney	NN
cord-320331-wtxja5i9	64	36	,	,	,
cord-320331-wtxja5i9	64	37	brain	brain	NN
cord-320331-wtxja5i9	64	38	,	,	,
cord-320331-wtxja5i9	64	39	and	and	CC
cord-320331-wtxja5i9	64	40	endothelial	endothelial	JJ
cord-320331-wtxja5i9	64	41	cells	cell	NNS
cord-320331-wtxja5i9	64	42	,	,	,
cord-320331-wtxja5i9	64	43	with	with	IN
cord-320331-wtxja5i9	64	44	the	the	DT
cord-320331-wtxja5i9	64	45	majority	majority	NN
cord-320331-wtxja5i9	64	46	seen	see	VBN
cord-320331-wtxja5i9	64	47	localizing	localize	VBG
cord-320331-wtxja5i9	64	48	in	in	IN
cord-320331-wtxja5i9	64	49	the	the	DT
cord-320331-wtxja5i9	64	50	tongue	tongue	NN
cord-320331-wtxja5i9	64	51	and	and	CC
cord-320331-wtxja5i9	64	52	esophageal	esophageal	JJ
cord-320331-wtxja5i9	64	53	epithelial	epithelial	JJ
cord-320331-wtxja5i9	64	54	cells	cell	NNS
cord-320331-wtxja5i9	64	55	,	,	,
cord-320331-wtxja5i9	64	56	enterocytes	enterocyte	NNS
cord-320331-wtxja5i9	64	57	,	,	,
cord-320331-wtxja5i9	64	58	male	male	JJ
cord-320331-wtxja5i9	64	59	reproductive	reproductive	JJ
cord-320331-wtxja5i9	64	60	cells	cell	NNS
cord-320331-wtxja5i9	64	61	,	,	,
cord-320331-wtxja5i9	64	62	type	type	NN
cord-320331-wtxja5i9	64	63	II	II	NNP
cord-320331-wtxja5i9	64	64	lung	lung	NN
cord-320331-wtxja5i9	64	65	alveolar	alveolar	NN
cord-320331-wtxja5i9	64	66	epithelial	epithelial	JJ
cord-320331-wtxja5i9	64	67	cells	cell	NNS
cord-320331-wtxja5i9	64	68	,	,	,
cord-320331-wtxja5i9	64	69	renal	renal	JJ
cord-320331-wtxja5i9	64	70	tubules	tubule	NNS
cord-320331-wtxja5i9	64	71	,	,	,
cord-320331-wtxja5i9	64	72	ductal	ductal	JJ
cord-320331-wtxja5i9	64	73	cells	cell	NNS
cord-320331-wtxja5i9	64	74	,	,	,
cord-320331-wtxja5i9	64	75	bladder	bladder	NN
cord-320331-wtxja5i9	64	76	urothelial	urothelial	JJ
cord-320331-wtxja5i9	64	77	cells	cell	NNS
cord-320331-wtxja5i9	64	78	,	,	,
cord-320331-wtxja5i9	64	79	endothelial	endothelial	JJ
cord-320331-wtxja5i9	64	80	cells	cell	NNS
cord-320331-wtxja5i9	64	81	,	,	,
cord-320331-wtxja5i9	64	82	and	and	CC
cord-320331-wtxja5i9	64	83	cardiomyocytes	cardiomyocyte	NNS
cord-320331-wtxja5i9	64	84	[	[	-LRB-
cord-320331-wtxja5i9	64	85	77	77	CD
cord-320331-wtxja5i9	64	86	,	,	,
cord-320331-wtxja5i9	64	87	78	78	CD
cord-320331-wtxja5i9	64	88	,	,	,
cord-320331-wtxja5i9	64	89	79	79	CD
cord-320331-wtxja5i9	64	90	,	,	,
cord-320331-wtxja5i9	64	91	80	80	CD
cord-320331-wtxja5i9	64	92	]	]	-RRB-
cord-320331-wtxja5i9	64	93	.	.	.
cord-320331-wtxja5i9	65	1	Interestingly	interestingly	RB
cord-320331-wtxja5i9	65	2	,	,	,
cord-320331-wtxja5i9	65	3	the	the	DT
cord-320331-wtxja5i9	65	4	number	number	NN
cord-320331-wtxja5i9	65	5	of	of	IN
cord-320331-wtxja5i9	65	6	organs	organ	NNS
cord-320331-wtxja5i9	65	7	that	that	WDT
cord-320331-wtxja5i9	65	8	express	express	VBP
cord-320331-wtxja5i9	65	9	ACE2	ACE2	NNP
cord-320331-wtxja5i9	65	10	continues	continue	VBZ
cord-320331-wtxja5i9	65	11	to	to	TO
cord-320331-wtxja5i9	65	12	increase	increase	VB
cord-320331-wtxja5i9	65	13	as	as	IN
cord-320331-wtxja5i9	65	14	more	more	JJR
cord-320331-wtxja5i9	65	15	data	data	NN
cord-320331-wtxja5i9	65	16	is	be	VBZ
cord-320331-wtxja5i9	65	17	published	publish	VBN
cord-320331-wtxja5i9	65	18	,	,	,
cord-320331-wtxja5i9	65	19	which	which	WDT
cord-320331-wtxja5i9	65	20	can	can	MD
cord-320331-wtxja5i9	65	21	be	be	VB
cord-320331-wtxja5i9	65	22	monitored	monitor	VBN
cord-320331-wtxja5i9	65	23	using	use	VBG
cord-320331-wtxja5i9	65	24	the	the	DT
cord-320331-wtxja5i9	65	25	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	65	26	Cell	Cell	NNP
cord-320331-wtxja5i9	65	27	Atlas	Atlas	NNP
cord-320331-wtxja5i9	65	28	database	database	NN
cord-320331-wtxja5i9	65	29	(	(	-LRB-
cord-320331-wtxja5i9	65	30	https://www.covid19cellatlas.org/	https://www.covid19cellatlas.org/	NNP
cord-320331-wtxja5i9	65	31	)	)	-RRB-
cord-320331-wtxja5i9	65	32	.	.	.
cord-320331-wtxja5i9	66	1	The	the	DT
cord-320331-wtxja5i9	66	2	ramifications	ramification	NNS
cord-320331-wtxja5i9	66	3	on	on	IN
cord-320331-wtxja5i9	66	4	the	the	DT
cord-320331-wtxja5i9	66	5	ability	ability	NN
cord-320331-wtxja5i9	66	6	of	of	IN
cord-320331-wtxja5i9	66	7	the	the	DT
cord-320331-wtxja5i9	66	8	virion	virion	NN
cord-320331-wtxja5i9	66	9	to	to	TO
cord-320331-wtxja5i9	66	10	provoke	provoke	VB
cord-320331-wtxja5i9	66	11	cellular	cellular	JJ
cord-320331-wtxja5i9	66	12	or	or	CC
cord-320331-wtxja5i9	66	13	tissue	tissue	NN
cord-320331-wtxja5i9	66	14	damage	damage	NN
cord-320331-wtxja5i9	66	15	remain	remain	VBP
cord-320331-wtxja5i9	66	16	intriguing	intriguing	JJ
cord-320331-wtxja5i9	66	17	,	,	,
cord-320331-wtxja5i9	66	18	but	but	CC
cord-320331-wtxja5i9	66	19	for	for	IN
cord-320331-wtxja5i9	66	20	one	one	CD
cord-320331-wtxja5i9	66	21	,	,	,
cord-320331-wtxja5i9	66	22	it	-PRON-	PRP
cord-320331-wtxja5i9	66	23	is	be	VBZ
cord-320331-wtxja5i9	66	24	dependent	dependent	JJ
cord-320331-wtxja5i9	66	25	not	not	RB
cord-320331-wtxja5i9	66	26	only	only	RB
cord-320331-wtxja5i9	66	27	on	on	IN
cord-320331-wtxja5i9	66	28	the	the	DT
cord-320331-wtxja5i9	66	29	presence	presence	NN
cord-320331-wtxja5i9	66	30	or	or	CC
cord-320331-wtxja5i9	66	31	absence	absence	NN
cord-320331-wtxja5i9	66	32	of	of	IN
cord-320331-wtxja5i9	66	33	ACE2	ACE2	NNP
cord-320331-wtxja5i9	66	34	but	but	CC
cord-320331-wtxja5i9	66	35	also	also	RB
cord-320331-wtxja5i9	66	36	on	on	IN
cord-320331-wtxja5i9	66	37	the	the	DT
cord-320331-wtxja5i9	66	38	amount	amount	NN
cord-320331-wtxja5i9	66	39	of	of	IN
cord-320331-wtxja5i9	66	40	ACE2	ACE2	NNP
cord-320331-wtxja5i9	66	41	on	on	IN
cord-320331-wtxja5i9	66	42	a	a	DT
cord-320331-wtxja5i9	66	43	certain	certain	JJ
cord-320331-wtxja5i9	66	44	organ	organ	NN
cord-320331-wtxja5i9	66	45	or	or	CC
cord-320331-wtxja5i9	66	46	tissue	tissue	NN
cord-320331-wtxja5i9	66	47	.	.	.
cord-320331-wtxja5i9	67	1	One	one	CD
cord-320331-wtxja5i9	67	2	of	of	IN
cord-320331-wtxja5i9	67	3	the	the	DT
cord-320331-wtxja5i9	67	4	most	most	RBS
cord-320331-wtxja5i9	67	5	commonly	commonly	RB
cord-320331-wtxja5i9	67	6	studied	study	VBN
cord-320331-wtxja5i9	67	7	regions	region	NNS
cord-320331-wtxja5i9	67	8	of	of	IN
cord-320331-wtxja5i9	67	9	SARS	SARS	NNP
cord-320331-wtxja5i9	67	10	-	-	HYPH
cord-320331-wtxja5i9	67	11	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	67	12	entry	entry	NN
cord-320331-wtxja5i9	67	13	is	be	VBZ
cord-320331-wtxja5i9	67	14	the	the	DT
cord-320331-wtxja5i9	67	15	respiratory	respiratory	JJ
cord-320331-wtxja5i9	67	16	system	system	NN
cord-320331-wtxja5i9	67	17	,	,	,
cord-320331-wtxja5i9	67	18	for	for	IN
cord-320331-wtxja5i9	67	19	which	which	WDT
cord-320331-wtxja5i9	67	20	it	-PRON-	PRP
cord-320331-wtxja5i9	67	21	is	be	VBZ
cord-320331-wtxja5i9	67	22	thought	think	VBN
cord-320331-wtxja5i9	67	23	to	to	TO
cord-320331-wtxja5i9	67	24	be	be	VB
cord-320331-wtxja5i9	67	25	the	the	DT
cord-320331-wtxja5i9	67	26	main	main	JJ
cord-320331-wtxja5i9	67	27	route	route	NN
cord-320331-wtxja5i9	67	28	of	of	IN
cord-320331-wtxja5i9	67	29	infection	infection	NN
cord-320331-wtxja5i9	67	30	,	,	,
cord-320331-wtxja5i9	67	31	transmission	transmission	NN
cord-320331-wtxja5i9	67	32	,	,	,
cord-320331-wtxja5i9	67	33	and	and	CC
cord-320331-wtxja5i9	67	34	pathophysiology	pathophysiology	NN
cord-320331-wtxja5i9	67	35	.	.	.
cord-320331-wtxja5i9	68	1	The	the	DT
cord-320331-wtxja5i9	68	2	specialized	specialized	JJ
cord-320331-wtxja5i9	68	3	type	type	NN
cord-320331-wtxja5i9	68	4	II	ii	CD
cord-320331-wtxja5i9	68	5	alveolar	alveolar	NN
cord-320331-wtxja5i9	68	6	cells	cell	NNS
cord-320331-wtxja5i9	68	7	express	express	VBP
cord-320331-wtxja5i9	68	8	an	an	DT
cord-320331-wtxja5i9	68	9	abundant	abundant	JJ
cord-320331-wtxja5i9	68	10	amount	amount	NN
cord-320331-wtxja5i9	68	11	of	of	IN
cord-320331-wtxja5i9	68	12	ACE2	ACE2	NNP
cord-320331-wtxja5i9	68	13	,	,	,
cord-320331-wtxja5i9	68	14	and	and	CC
cord-320331-wtxja5i9	68	15	ACE2	ACE2	NNP
cord-320331-wtxja5i9	68	16	inactivity	inactivity	NN
cord-320331-wtxja5i9	68	17	due	due	IN
cord-320331-wtxja5i9	68	18	to	to	IN
cord-320331-wtxja5i9	68	19	SARS	SARS	NNP
cord-320331-wtxja5i9	68	20	-	-	HYPH
cord-320331-wtxja5i9	68	21	CoV-2-induced	CoV-2-induced	NNP
cord-320331-wtxja5i9	68	22	J	J	NNP
cord-320331-wtxja5i9	68	23	o	o	NN
cord-320331-wtxja5i9	68	24	u	u	NN
cord-320331-wtxja5i9	68	25	r	r	NN
cord-320331-wtxja5i9	68	26	n	n	NN
cord-320331-wtxja5i9	68	27	a	a	DT
cord-320331-wtxja5i9	68	28	l	l	NN
cord-320331-wtxja5i9	68	29	P	p	NN
cord-320331-wtxja5i9	68	30	r	r	NN
cord-320331-wtxja5i9	68	31	e	e	NN
cord-320331-wtxja5i9	68	32	-p	-p	NN
cord-320331-wtxja5i9	69	1	r	r	LS
cord-320331-wtxja5i9	70	1	o	o	UH
cord-320331-wtxja5i9	70	2	o	o	NN
cord-320331-wtxja5i9	71	1	f	f	LS
cord-320331-wtxja5i9	71	2	depletion	depletion	NN
cord-320331-wtxja5i9	71	3	early	early	RB
cord-320331-wtxja5i9	71	4	in	in	IN
cord-320331-wtxja5i9	71	5	the	the	DT
cord-320331-wtxja5i9	71	6	infection	infection	NN
cord-320331-wtxja5i9	71	7	may	may	MD
cord-320331-wtxja5i9	71	8	disturb	disturb	VB
cord-320331-wtxja5i9	71	9	the	the	DT
cord-320331-wtxja5i9	71	10	RAS	RAS	NNP
cord-320331-wtxja5i9	71	11	homeostasis	homeostasis	NN
cord-320331-wtxja5i9	71	12	,	,	,
cord-320331-wtxja5i9	71	13	leading	lead	VBG
cord-320331-wtxja5i9	71	14	to	to	IN
cord-320331-wtxja5i9	71	15	impaired	impaired	JJ
cord-320331-wtxja5i9	71	16	tissue	tissue	NN
cord-320331-wtxja5i9	71	17	repair	repair	NN
cord-320331-wtxja5i9	71	18	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	71	19	,	,	,
cord-320331-wtxja5i9	71	20	increased	increase	VBD
cord-320331-wtxja5i9	71	21	vascular	vascular	JJ
cord-320331-wtxja5i9	71	22	permeability	permeability	NN
cord-320331-wtxja5i9	71	23	,	,	,
cord-320331-wtxja5i9	71	24	fluid	fluid	JJ
cord-320331-wtxja5i9	71	25	accumulation	accumulation	NN
cord-320331-wtxja5i9	71	26	in	in	IN
cord-320331-wtxja5i9	71	27	extra	extra	JJ
cord-320331-wtxja5i9	71	28	-	-	JJ
cord-320331-wtxja5i9	71	29	alveolar	alveolar	JJ
cord-320331-wtxja5i9	71	30	spaces	space	NNS
cord-320331-wtxja5i9	71	31	,	,	,
cord-320331-wtxja5i9	71	32	and	and	CC
cord-320331-wtxja5i9	71	33	oxidant	oxidant	JJ
cord-320331-wtxja5i9	71	34	/	/	SYM
cord-320331-wtxja5i9	71	35	antioxidant	antioxidant	NN
cord-320331-wtxja5i9	71	36	imbalance	imbalance	NN
cord-320331-wtxja5i9	71	37	[	[	-LRB-
cord-320331-wtxja5i9	71	38	81	81	CD
cord-320331-wtxja5i9	71	39	]	]	-RRB-
cord-320331-wtxja5i9	71	40	.	.	.
cord-320331-wtxja5i9	72	1	In	in	IN
cord-320331-wtxja5i9	72	2	a	a	DT
cord-320331-wtxja5i9	72	3	study	study	NN
cord-320331-wtxja5i9	72	4	by	by	IN
cord-320331-wtxja5i9	72	5	Ackerman	Ackerman	NNP
cord-320331-wtxja5i9	72	6	et	et	NNP
cord-320331-wtxja5i9	72	7	.	.	.
cord-320331-wtxja5i9	73	1	al	al	NNP
cord-320331-wtxja5i9	73	2	.	.	NNP
cord-320331-wtxja5i9	73	3	,	,	,
cord-320331-wtxja5i9	73	4	which	which	WDT
cord-320331-wtxja5i9	73	5	examined	examine	VBD
cord-320331-wtxja5i9	73	6	postmortem	postmortem	JJ
cord-320331-wtxja5i9	73	7	lungs	lung	NNS
cord-320331-wtxja5i9	73	8	of	of	IN
cord-320331-wtxja5i9	73	9	patients	patient	NNS
cord-320331-wtxja5i9	73	10	who	who	WP
cord-320331-wtxja5i9	73	11	died	die	VBD
cord-320331-wtxja5i9	73	12	from	from	IN
cord-320331-wtxja5i9	73	13	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	73	14	and	and	CC
cord-320331-wtxja5i9	73	15	compared	compare	VBD
cord-320331-wtxja5i9	73	16	them	-PRON-	PRP
cord-320331-wtxja5i9	73	17	to	to	IN
cord-320331-wtxja5i9	73	18	7	7	CD
cord-320331-wtxja5i9	73	19	lungs	lung	NNS
cord-320331-wtxja5i9	73	20	obtained	obtain	VBN
cord-320331-wtxja5i9	73	21	from	from	IN
cord-320331-wtxja5i9	73	22	patients	patient	NNS
cord-320331-wtxja5i9	73	23	who	who	WP
cord-320331-wtxja5i9	73	24	died	die	VBD
cord-320331-wtxja5i9	73	25	from	from	IN
cord-320331-wtxja5i9	73	26	ARDS	ARDS	NNP
cord-320331-wtxja5i9	73	27	secondary	secondary	JJ
cord-320331-wtxja5i9	73	28	to	to	IN
cord-320331-wtxja5i9	73	29	AH1N1	ah1n1	NN
cord-320331-wtxja5i9	73	30	and	and	CC
cord-320331-wtxja5i9	73	31	to	to	IN
cord-320331-wtxja5i9	73	32	10	10	CD
cord-320331-wtxja5i9	73	33	age	age	NN
cord-320331-wtxja5i9	73	34	-	-	HYPH
cord-320331-wtxja5i9	73	35	matched	match	VBN
cord-320331-wtxja5i9	73	36	healthy	healthy	JJ
cord-320331-wtxja5i9	73	37	lungs	lung	NNS
cord-320331-wtxja5i9	73	38	,	,	,
cord-320331-wtxja5i9	73	39	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	73	40	patients	patient	NNS
cord-320331-wtxja5i9	73	41	were	be	VBD
cord-320331-wtxja5i9	73	42	found	find	VBN
cord-320331-wtxja5i9	73	43	to	to	TO
cord-320331-wtxja5i9	73	44	suffer	suffer	VB
cord-320331-wtxja5i9	73	45	more	more	RBR
cord-320331-wtxja5i9	73	46	frequently	frequently	RB
cord-320331-wtxja5i9	73	47	from	from	IN
cord-320331-wtxja5i9	73	48	severe	severe	JJ
cord-320331-wtxja5i9	73	49	endothelial	endothelial	JJ
cord-320331-wtxja5i9	73	50	injury	injury	NN
cord-320331-wtxja5i9	73	51	due	due	IN
cord-320331-wtxja5i9	73	52	to	to	IN
cord-320331-wtxja5i9	73	53	cell	cell	NN
cord-320331-wtxja5i9	73	54	membrane	membrane	NN
cord-320331-wtxja5i9	73	55	damage	damage	NN
cord-320331-wtxja5i9	73	56	by	by	IN
cord-320331-wtxja5i9	73	57	presence	presence	NN
cord-320331-wtxja5i9	73	58	of	of	IN
cord-320331-wtxja5i9	73	59	SARS	SARS	NNP
cord-320331-wtxja5i9	73	60	-	-	HYPH
cord-320331-wtxja5i9	73	61	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	73	62	.	.	.
cord-320331-wtxja5i9	74	1	Widespread	widespread	JJ
cord-320331-wtxja5i9	74	2	thrombosis	thrombosis	NN
cord-320331-wtxja5i9	74	3	with	with	IN
cord-320331-wtxja5i9	74	4	microangiopathy	microangiopathy	NNP
cord-320331-wtxja5i9	74	5	was	be	VBD
cord-320331-wtxja5i9	74	6	seen	see	VBN
cord-320331-wtxja5i9	74	7	,	,	,
cord-320331-wtxja5i9	74	8	and	and	CC
cord-320331-wtxja5i9	74	9	patients	patient	NNS
cord-320331-wtxja5i9	74	10	were	be	VBD
cord-320331-wtxja5i9	74	11	9	9	CD
cord-320331-wtxja5i9	74	12	times	time	NNS
cord-320331-wtxja5i9	74	13	more	more	RBR
cord-320331-wtxja5i9	74	14	likely	likely	JJ
cord-320331-wtxja5i9	74	15	to	to	TO
cord-320331-wtxja5i9	74	16	experience	experience	VB
cord-320331-wtxja5i9	74	17	alveolar	alveolar	NN
cord-320331-wtxja5i9	74	18	capillary	capillary	JJ
cord-320331-wtxja5i9	74	19	microthrombi	microthrombi	NN
cord-320331-wtxja5i9	74	20	,	,	,
cord-320331-wtxja5i9	74	21	and	and	CC
cord-320331-wtxja5i9	74	22	2.7	2.7	CD
cord-320331-wtxja5i9	74	23	times	time	NNS
cord-320331-wtxja5i9	74	24	more	more	RBR
cord-320331-wtxja5i9	74	25	likely	likely	JJ
cord-320331-wtxja5i9	74	26	to	to	TO
cord-320331-wtxja5i9	74	27	experience	experience	VB
cord-320331-wtxja5i9	74	28	intussusceptive	intussusceptive	JJ
cord-320331-wtxja5i9	74	29	angiogenesis	angiogenesis	NN
cord-320331-wtxja5i9	74	30	than	than	IN
cord-320331-wtxja5i9	74	31	with	with	IN
cord-320331-wtxja5i9	74	32	flu	flu	NN
cord-320331-wtxja5i9	74	33	[	[	-LRB-
cord-320331-wtxja5i9	74	34	82	82	CD
cord-320331-wtxja5i9	74	35	]	]	-RRB-
cord-320331-wtxja5i9	74	36	.	.	.
cord-320331-wtxja5i9	75	1	This	this	DT
cord-320331-wtxja5i9	75	2	phenomenon	phenomenon	NN
cord-320331-wtxja5i9	75	3	of	of	IN
cord-320331-wtxja5i9	75	4	thrombosis	thrombosis	NN
cord-320331-wtxja5i9	75	5	and	and	CC
cord-320331-wtxja5i9	75	6	other	other	JJ
cord-320331-wtxja5i9	75	7	vascular	vascular	JJ
cord-320331-wtxja5i9	75	8	events	event	NNS
cord-320331-wtxja5i9	75	9	in	in	IN
cord-320331-wtxja5i9	75	10	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	75	11	is	be	VBZ
cord-320331-wtxja5i9	75	12	likely	likely	RB
cord-320331-wtxja5i9	75	13	the	the	DT
cord-320331-wtxja5i9	75	14	result	result	NN
cord-320331-wtxja5i9	75	15	of	of	IN
cord-320331-wtxja5i9	75	16	an	an	DT
cord-320331-wtxja5i9	75	17	abundance	abundance	NN
cord-320331-wtxja5i9	75	18	of	of	IN
cord-320331-wtxja5i9	75	19	ACE2	ACE2	NNP
cord-320331-wtxja5i9	75	20	in	in	IN
cord-320331-wtxja5i9	75	21	endothelial	endothelial	JJ
cord-320331-wtxja5i9	75	22	cells	cell	NNS
cord-320331-wtxja5i9	75	23	,	,	,
cord-320331-wtxja5i9	75	24	which	which	WDT
cord-320331-wtxja5i9	75	25	permits	permit	VBZ
cord-320331-wtxja5i9	75	26	SARS	SARS	NNP
cord-320331-wtxja5i9	75	27	-	-	HYPH
cord-320331-wtxja5i9	75	28	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	75	29	infection	infection	NN
cord-320331-wtxja5i9	75	30	along	along	IN
cord-320331-wtxja5i9	75	31	the	the	DT
cord-320331-wtxja5i9	75	32	endothelium	endothelium	NN
cord-320331-wtxja5i9	75	33	.	.	.
cord-320331-wtxja5i9	76	1	This	this	DT
cord-320331-wtxja5i9	76	2	will	will	MD
cord-320331-wtxja5i9	76	3	be	be	VB
cord-320331-wtxja5i9	76	4	further	further	RB
cord-320331-wtxja5i9	76	5	discussed	discuss	VBN
cord-320331-wtxja5i9	76	6	in	in	IN
cord-320331-wtxja5i9	76	7	later	later	JJ
cord-320331-wtxja5i9	76	8	sections	section	NNS
cord-320331-wtxja5i9	76	9	.	.	.
cord-320331-wtxja5i9	77	1	SARS	SARS	NNP
cord-320331-wtxja5i9	77	2	-	-	HYPH
cord-320331-wtxja5i9	77	3	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	77	4	has	have	VBZ
cord-320331-wtxja5i9	77	5	also	also	RB
cord-320331-wtxja5i9	77	6	been	be	VBN
cord-320331-wtxja5i9	77	7	studied	study	VBN
cord-320331-wtxja5i9	77	8	to	to	TO
cord-320331-wtxja5i9	77	9	disseminate	disseminate	VB
cord-320331-wtxja5i9	77	10	into	into	IN
cord-320331-wtxja5i9	77	11	the	the	DT
cord-320331-wtxja5i9	77	12	CNS	CNS	NNP
cord-320331-wtxja5i9	77	13	,	,	,
cord-320331-wtxja5i9	77	14	by	by	IN
cord-320331-wtxja5i9	77	15	initially	initially	RB
cord-320331-wtxja5i9	77	16	invading	invade	VBG
cord-320331-wtxja5i9	77	17	the	the	DT
cord-320331-wtxja5i9	77	18	peripheral	peripheral	JJ
cord-320331-wtxja5i9	77	19	nerve	nerve	NN
cord-320331-wtxja5i9	77	20	terminals	terminal	NNS
cord-320331-wtxja5i9	77	21	via	via	IN
cord-320331-wtxja5i9	77	22	the	the	DT
cord-320331-wtxja5i9	77	23	synapse	synapse	NN
cord-320331-wtxja5i9	77	24	-	-	HYPH
cord-320331-wtxja5i9	77	25	connected	connect	VBN
cord-320331-wtxja5i9	77	26	route	route	NN
cord-320331-wtxja5i9	77	27	,	,	,
cord-320331-wtxja5i9	77	28	through	through	IN
cord-320331-wtxja5i9	77	29	the	the	DT
cord-320331-wtxja5i9	77	30	mechanoreceptors	mechanoreceptor	NNS
cord-320331-wtxja5i9	77	31	and	and	CC
cord-320331-wtxja5i9	77	32	chemoreceptors	chemoreceptor	NNS
cord-320331-wtxja5i9	77	33	in	in	IN
cord-320331-wtxja5i9	77	34	the	the	DT
cord-320331-wtxja5i9	77	35	lungs	lung	NNS
cord-320331-wtxja5i9	77	36	,	,	,
cord-320331-wtxja5i9	77	37	and	and	CC
cord-320331-wtxja5i9	77	38	into	into	IN
cord-320331-wtxja5i9	77	39	the	the	DT
cord-320331-wtxja5i9	77	40	medullary	medullary	JJ
cord-320331-wtxja5i9	77	41	-	-	HYPH
cord-320331-wtxja5i9	77	42	cardiorespiratory	cardiorespiratory	JJ
cord-320331-wtxja5i9	77	43	center	center	NN
cord-320331-wtxja5i9	77	44	[	[	-LRB-
cord-320331-wtxja5i9	77	45	83	83	CD
cord-320331-wtxja5i9	77	46	,	,	,
cord-320331-wtxja5i9	77	47	84	84	CD
cord-320331-wtxja5i9	77	48	]	]	-RRB-
cord-320331-wtxja5i9	77	49	.	.	.
cord-320331-wtxja5i9	78	1	However	however	RB
cord-320331-wtxja5i9	78	2	,	,	,
cord-320331-wtxja5i9	78	3	ACE2	ACE2	NNP
cord-320331-wtxja5i9	78	4	is	be	VBZ
cord-320331-wtxja5i9	78	5	not	not	RB
cord-320331-wtxja5i9	78	6	particularly	particularly	RB
cord-320331-wtxja5i9	78	7	abundant	abundant	JJ
cord-320331-wtxja5i9	78	8	in	in	IN
cord-320331-wtxja5i9	78	9	neurons	neuron	NNS
cord-320331-wtxja5i9	78	10	,	,	,
cord-320331-wtxja5i9	78	11	and	and	CC
cord-320331-wtxja5i9	78	12	other	other	JJ
cord-320331-wtxja5i9	78	13	pathways	pathway	NNS
cord-320331-wtxja5i9	78	14	of	of	IN
cord-320331-wtxja5i9	78	15	infection	infection	NN
cord-320331-wtxja5i9	78	16	are	be	VBP
cord-320331-wtxja5i9	78	17	being	be	VBG
cord-320331-wtxja5i9	78	18	investigated	investigate	VBN
cord-320331-wtxja5i9	78	19	.	.	.
cord-320331-wtxja5i9	79	1	The	the	DT
cord-320331-wtxja5i9	79	2	oral	oral	JJ
cord-320331-wtxja5i9	79	3	and	and	CC
cord-320331-wtxja5i9	79	4	nasal	nasal	JJ
cord-320331-wtxja5i9	79	5	mucosa	mucosa	NN
cord-320331-wtxja5i9	79	6	also	also	RB
cord-320331-wtxja5i9	79	7	holds	hold	VBZ
cord-320331-wtxja5i9	79	8	a	a	DT
cord-320331-wtxja5i9	79	9	significant	significant	JJ
cord-320331-wtxja5i9	79	10	distribution	distribution	NN
cord-320331-wtxja5i9	79	11	of	of	IN
cord-320331-wtxja5i9	79	12	ACE2	ACE2	NNP
cord-320331-wtxja5i9	79	13	,	,	,
cord-320331-wtxja5i9	79	14	especially	especially	RB
cord-320331-wtxja5i9	79	15	on	on	IN
cord-320331-wtxja5i9	79	16	the	the	DT
cord-320331-wtxja5i9	79	17	tongue	tongue	NN
cord-320331-wtxja5i9	79	18	epithelial	epithelial	JJ
cord-320331-wtxja5i9	79	19	cells	cell	NNS
cord-320331-wtxja5i9	79	20	,	,	,
cord-320331-wtxja5i9	79	21	which	which	WDT
cord-320331-wtxja5i9	79	22	may	may	MD
cord-320331-wtxja5i9	79	23	explain	explain	VB
cord-320331-wtxja5i9	79	24	its	-PRON-	PRP$
cord-320331-wtxja5i9	79	25	route	route	NN
cord-320331-wtxja5i9	79	26	of	of	IN
cord-320331-wtxja5i9	79	27	infection	infection	NN
cord-320331-wtxja5i9	79	28	[	[	-LRB-
cord-320331-wtxja5i9	79	29	80	80	CD
cord-320331-wtxja5i9	79	30	]	]	-RRB-
cord-320331-wtxja5i9	79	31	.	.	.
cord-320331-wtxja5i9	80	1	If	if	IN
cord-320331-wtxja5i9	80	2	and	and	CC
cord-320331-wtxja5i9	80	3	how	how	WRB
cord-320331-wtxja5i9	80	4	the	the	DT
cord-320331-wtxja5i9	80	5	virus	virus	NN
cord-320331-wtxja5i9	80	6	affects	affect	VBZ
cord-320331-wtxja5i9	80	7	the	the	DT
cord-320331-wtxja5i9	80	8	activity	activity	NN
cord-320331-wtxja5i9	80	9	of	of	IN
cord-320331-wtxja5i9	80	10	the	the	DT
cord-320331-wtxja5i9	80	11	tongue	tongue	NN
cord-320331-wtxja5i9	80	12	epithelial	epithelial	JJ
cord-320331-wtxja5i9	80	13	cells	cell	NNS
cord-320331-wtxja5i9	80	14	were	be	VBD
cord-320331-wtxja5i9	80	15	investigated	investigate	VBN
cord-320331-wtxja5i9	80	16	by	by	IN
cord-320331-wtxja5i9	80	17	a	a	DT
cord-320331-wtxja5i9	80	18	cross	cross	JJ
cord-320331-wtxja5i9	80	19	-	-	JJ
cord-320331-wtxja5i9	80	20	sectional	sectional	JJ
cord-320331-wtxja5i9	80	21	study	study	NN
cord-320331-wtxja5i9	80	22	in	in	IN
cord-320331-wtxja5i9	80	23	L.	L.	NNP
cord-320331-wtxja5i9	80	24	Sacco	Sacco	NNP
cord-320331-wtxja5i9	80	25	Hospital	Hospital	NNP
cord-320331-wtxja5i9	80	26	in	in	IN
cord-320331-wtxja5i9	80	27	Milan	Milan	NNP
cord-320331-wtxja5i9	80	28	,	,	,
cord-320331-wtxja5i9	80	29	Italy	Italy	NNP
cord-320331-wtxja5i9	80	30	,	,	,
cord-320331-wtxja5i9	80	31	where	where	WRB
cord-320331-wtxja5i9	80	32	the	the	DT
cord-320331-wtxja5i9	80	33	prevalence	prevalence	NN
cord-320331-wtxja5i9	80	34	of	of	IN
cord-320331-wtxja5i9	80	35	olfactory	olfactory	NN
cord-320331-wtxja5i9	80	36	and	and	CC
cord-320331-wtxja5i9	80	37	taste	taste	NN
cord-320331-wtxja5i9	80	38	disorders	disorder	NNS
cord-320331-wtxja5i9	80	39	in	in	IN
cord-320331-wtxja5i9	80	40	hospitalized	hospitalize	VBN
cord-320331-wtxja5i9	80	41	COVID-19	covid-19	CD
cord-320331-wtxja5i9	80	42	patients	patient	NNS
cord-320331-wtxja5i9	80	43	were	be	VBD
cord-320331-wtxja5i9	80	44	obtained	obtain	VBN
cord-320331-wtxja5i9	80	45	.	.	.
cord-320331-wtxja5i9	81	1	Of	of	IN
cord-320331-wtxja5i9	81	2	the	the	DT
cord-320331-wtxja5i9	81	3	88	88	CD
cord-320331-wtxja5i9	81	4	hospitalized	hospitalize	VBN
cord-320331-wtxja5i9	81	5	COVID-19	covid-19	CD
cord-320331-wtxja5i9	81	6	patients	patient	NNS
cord-320331-wtxja5i9	81	7	,	,	,
cord-320331-wtxja5i9	81	8	all	all	DT
cord-320331-wtxja5i9	81	9	59	59	CD
cord-320331-wtxja5i9	81	10	patients	patient	NNS
cord-320331-wtxja5i9	81	11	who	who	WP
cord-320331-wtxja5i9	81	12	were	be	VBD
cord-320331-wtxja5i9	81	13	coherent	coherent	JJ
cord-320331-wtxja5i9	81	14	and	and	CC
cord-320331-wtxja5i9	81	15	responsive	responsive	JJ
cord-320331-wtxja5i9	81	16	reported	report	VBD
cord-320331-wtxja5i9	81	17	the	the	DT
cord-320331-wtxja5i9	81	18	persistence	persistence	NN
cord-320331-wtxja5i9	81	19	of	of	IN
cord-320331-wtxja5i9	81	20	olfactory	olfactory	NN
cord-320331-wtxja5i9	81	21	and	and	CC
cord-320331-wtxja5i9	81	22	taste	taste	NN
cord-320331-wtxja5i9	81	23	disorders	disorder	NNS
cord-320331-wtxja5i9	81	24	throughout	throughout	IN
cord-320331-wtxja5i9	81	25	the	the	DT
cord-320331-wtxja5i9	81	26	disease	disease	NN
cord-320331-wtxja5i9	81	27	[	[	-LRB-
cord-320331-wtxja5i9	81	28	85	85	CD
cord-320331-wtxja5i9	81	29	]	]	-RRB-
cord-320331-wtxja5i9	81	30	,	,	,
cord-320331-wtxja5i9	81	31	indirectly	indirectly	RB
cord-320331-wtxja5i9	81	32	supporting	support	VBG
cord-320331-wtxja5i9	81	33	the	the	DT
cord-320331-wtxja5i9	81	34	hypothesis	hypothesis	NN
cord-320331-wtxja5i9	81	35	of	of	IN
cord-320331-wtxja5i9	81	36	oral	oral	JJ
cord-320331-wtxja5i9	81	37	and	and	CC
cord-320331-wtxja5i9	81	38	mucosal	mucosal	JJ
cord-320331-wtxja5i9	81	39	routes	route	NNS
cord-320331-wtxja5i9	81	40	of	of	IN
cord-320331-wtxja5i9	81	41	invasion	invasion	NN
cord-320331-wtxja5i9	81	42	to	to	IN
cord-320331-wtxja5i9	81	43	the	the	DT
cord-320331-wtxja5i9	81	44	nervous	nervous	JJ
cord-320331-wtxja5i9	81	45	system	system	NN
cord-320331-wtxja5i9	81	46	.	.	.
cord-320331-wtxja5i9	82	1	Interestingly	interestingly	RB
cord-320331-wtxja5i9	82	2	,	,	,
cord-320331-wtxja5i9	82	3	ACE2	ACE2	NNP
cord-320331-wtxja5i9	82	4	population	population	NN
cord-320331-wtxja5i9	82	5	is	be	VBZ
cord-320331-wtxja5i9	82	6	also	also	RB
cord-320331-wtxja5i9	82	7	pervasively	pervasively	RB
cord-320331-wtxja5i9	82	8	seen	see	VBN
cord-320331-wtxja5i9	82	9	in	in	IN
cord-320331-wtxja5i9	82	10	pancreatic	pancreatic	JJ
cord-320331-wtxja5i9	82	11	cells	cell	NNS
cord-320331-wtxja5i9	82	12	,	,	,
cord-320331-wtxja5i9	82	13	which	which	WDT
cord-320331-wtxja5i9	82	14	in	in	IN
cord-320331-wtxja5i9	82	15	fact	fact	NN
cord-320331-wtxja5i9	82	16	shows	show	VBZ
cord-320331-wtxja5i9	82	17	a	a	DT
cord-320331-wtxja5i9	82	18	higher	high	JJR
cord-320331-wtxja5i9	82	19	expression	expression	NN
cord-320331-wtxja5i9	82	20	profile	profile	NN
cord-320331-wtxja5i9	82	21	than	than	IN
cord-320331-wtxja5i9	82	22	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	82	23	cells	cell	NNS
cord-320331-wtxja5i9	82	24	.	.	.
cord-320331-wtxja5i9	83	1	This	this	DT
cord-320331-wtxja5i9	83	2	possibly	possibly	RB
cord-320331-wtxja5i9	83	3	makes	make	VBZ
cord-320331-wtxja5i9	83	4	the	the	DT
cord-320331-wtxja5i9	83	5	pancreas	pancreas	NN
cord-320331-wtxja5i9	83	6	,	,	,
cord-320331-wtxja5i9	83	7	by	by	IN
cord-320331-wtxja5i9	83	8	virtue	virtue	NN
cord-320331-wtxja5i9	83	9	of	of	IN
cord-320331-wtxja5i9	83	10	ACE2-dependent	ACE2-dependent	NNP
cord-320331-wtxja5i9	83	11	viral	viral	JJ
cord-320331-wtxja5i9	83	12	entry	entry	NN
cord-320331-wtxja5i9	83	13	,	,	,
cord-320331-wtxja5i9	83	14	one	one	CD
cord-320331-wtxja5i9	83	15	of	of	IN
cord-320331-wtxja5i9	83	16	the	the	DT
cord-320331-wtxja5i9	83	17	major	major	JJ
cord-320331-wtxja5i9	83	18	targets	target	NNS
cord-320331-wtxja5i9	83	19	of	of	IN
cord-320331-wtxja5i9	83	20	SARS	SARS	NNP
cord-320331-wtxja5i9	83	21	-	-	HYPH
cord-320331-wtxja5i9	83	22	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	83	23	.	.	.
cord-320331-wtxja5i9	84	1	Complications	complication	NNS
cord-320331-wtxja5i9	84	2	may	may	MD
cord-320331-wtxja5i9	84	3	include	include	VB
cord-320331-wtxja5i9	84	4	acute	acute	JJ
cord-320331-wtxja5i9	84	5	pancreatitis	pancreatitis	NN
cord-320331-wtxja5i9	84	6	resulting	result	VBG
cord-320331-wtxja5i9	84	7	from	from	IN
cord-320331-wtxja5i9	84	8	direct	direct	JJ
cord-320331-wtxja5i9	84	9	injury	injury	NN
cord-320331-wtxja5i9	84	10	to	to	IN
cord-320331-wtxja5i9	84	11	pancreatic	pancreatic	JJ
cord-320331-wtxja5i9	84	12	acinar	acinar	JJ
cord-320331-wtxja5i9	84	13	cells	cell	NNS
cord-320331-wtxja5i9	84	14	or	or	CC
cord-320331-wtxja5i9	84	15	uncontrollable	uncontrollable	JJ
cord-320331-wtxja5i9	84	16	systemic	systemic	JJ
cord-320331-wtxja5i9	84	17	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	84	18	response	response	NN
cord-320331-wtxja5i9	84	19	from	from	IN
cord-320331-wtxja5i9	84	20	cytokine	cytokine	NN
cord-320331-wtxja5i9	84	21	storm	storm	NN
cord-320331-wtxja5i9	84	22	syndrome	syndrome	NN
cord-320331-wtxja5i9	84	23	,	,	,
cord-320331-wtxja5i9	84	24	both	both	DT
cord-320331-wtxja5i9	84	25	of	of	IN
cord-320331-wtxja5i9	84	26	which	which	WDT
cord-320331-wtxja5i9	84	27	have	have	VBP
cord-320331-wtxja5i9	84	28	been	be	VBN
cord-320331-wtxja5i9	84	29	documented	document	VBN
cord-320331-wtxja5i9	84	30	in	in	IN
cord-320331-wtxja5i9	84	31	the	the	DT
cord-320331-wtxja5i9	84	32	disease	disease	NN
cord-320331-wtxja5i9	84	33	[	[	-LRB-
cord-320331-wtxja5i9	84	34	86	86	CD
cord-320331-wtxja5i9	84	35	]	]	-RRB-
cord-320331-wtxja5i9	84	36	.	.	.
cord-320331-wtxja5i9	85	1	Acute	acute	JJ
cord-320331-wtxja5i9	85	2	pancreatitis	pancreatitis	NN
cord-320331-wtxja5i9	85	3	due	due	IN
cord-320331-wtxja5i9	85	4	to	to	IN
cord-320331-wtxja5i9	85	5	SARS	SARS	NNP
cord-320331-wtxja5i9	85	6	-	-	HYPH
cord-320331-wtxja5i9	85	7	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	85	8	infection	infection	NN
cord-320331-wtxja5i9	85	9	could	could	MD
cord-320331-wtxja5i9	85	10	pose	pose	VB
cord-320331-wtxja5i9	85	11	an	an	DT
cord-320331-wtxja5i9	85	12	additional	additional	JJ
cord-320331-wtxja5i9	85	13	threat	threat	NN
cord-320331-wtxja5i9	85	14	to	to	IN
cord-320331-wtxja5i9	85	15	people	people	NNS
cord-320331-wtxja5i9	85	16	afflicted	afflict	VBN
cord-320331-wtxja5i9	85	17	with	with	IN
cord-320331-wtxja5i9	85	18	diabetes	diabetes	NN
cord-320331-wtxja5i9	85	19	mellitus	mellitus	NN
cord-320331-wtxja5i9	85	20	(	(	-LRB-
cord-320331-wtxja5i9	85	21	DM	DM	NNP
cord-320331-wtxja5i9	85	22	)	)	-RRB-
cord-320331-wtxja5i9	85	23	types	type	NNS
cord-320331-wtxja5i9	85	24	1	1	CD
cord-320331-wtxja5i9	85	25	and	and	CC
cord-320331-wtxja5i9	85	26	2	2	CD
cord-320331-wtxja5i9	85	27	by	by	IN
cord-320331-wtxja5i9	85	28	promoting	promote	VBG
cord-320331-wtxja5i9	85	29	metabolic	metabolic	JJ
cord-320331-wtxja5i9	85	30	complications	complication	NNS
cord-320331-wtxja5i9	85	31	as	as	IN
cord-320331-wtxja5i9	85	32	the	the	DT
cord-320331-wtxja5i9	85	33	infection	infection	NN
cord-320331-wtxja5i9	85	34	continues	continue	VBZ
cord-320331-wtxja5i9	85	35	to	to	TO
cord-320331-wtxja5i9	85	36	alter	alter	VB
cord-320331-wtxja5i9	85	37	pancreatic	pancreatic	NN
cord-320331-wtxja5i9	85	38	β	β	NN
cord-320331-wtxja5i9	85	39	-	-	HYPH
cord-320331-wtxja5i9	85	40	cell	cell	NN
cord-320331-wtxja5i9	85	41	function	function	NN
cord-320331-wtxja5i9	85	42	,	,	,
cord-320331-wtxja5i9	85	43	which	which	WDT
cord-320331-wtxja5i9	85	44	may	may	MD
cord-320331-wtxja5i9	85	45	in	in	IN
cord-320331-wtxja5i9	85	46	fact	fact	NN
cord-320331-wtxja5i9	85	47	explain	explain	VB
cord-320331-wtxja5i9	85	48	the	the	DT
cord-320331-wtxja5i9	85	49	feared	fear	VBN
cord-320331-wtxja5i9	85	50	risks	risk	NNS
cord-320331-wtxja5i9	85	51	of	of	IN
cord-320331-wtxja5i9	85	52	severe	severe	JJ
cord-320331-wtxja5i9	85	53	COVID-19	covid-19	NN
cord-320331-wtxja5i9	85	54	among	among	IN
cord-320331-wtxja5i9	85	55	patients	patient	NNS
cord-320331-wtxja5i9	85	56	with	with	IN
cord-320331-wtxja5i9	85	57	DM	DM	NNP
cord-320331-wtxja5i9	85	58	[	[	-LRB-
cord-320331-wtxja5i9	85	59	87	87	CD
cord-320331-wtxja5i9	85	60	]	]	-RRB-
cord-320331-wtxja5i9	85	61	.	.	.
cord-320331-wtxja5i9	86	1	In	in	IN
cord-320331-wtxja5i9	86	2	the	the	DT
cord-320331-wtxja5i9	86	3	kidneys	kidney	NNS
cord-320331-wtxja5i9	86	4	,	,	,
cord-320331-wtxja5i9	86	5	the	the	DT
cord-320331-wtxja5i9	86	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	86	7	expression	expression	NN
cord-320331-wtxja5i9	86	8	in	in	IN
cord-320331-wtxja5i9	86	9	the	the	DT
cord-320331-wtxja5i9	86	10	proximal	proximal	JJ
cord-320331-wtxja5i9	86	11	tubules	tubule	NNS
cord-320331-wtxja5i9	86	12	remains	remain	VBZ
cord-320331-wtxja5i9	86	13	the	the	DT
cord-320331-wtxja5i9	86	14	highest	high	JJS
cord-320331-wtxja5i9	86	15	in	in	IN
cord-320331-wtxja5i9	86	16	concentration	concentration	NN
cord-320331-wtxja5i9	86	17	,	,	,
cord-320331-wtxja5i9	86	18	with	with	IN
cord-320331-wtxja5i9	86	19	markedly	markedly	RB
cord-320331-wtxja5i9	86	20	lower	low	JJR
cord-320331-wtxja5i9	86	21	concentrations	concentration	NNS
cord-320331-wtxja5i9	86	22	in	in	IN
cord-320331-wtxja5i9	86	23	the	the	DT
cord-320331-wtxja5i9	86	24	glomeruli	glomerulus	NNS
cord-320331-wtxja5i9	86	25	[	[	-LRB-
cord-320331-wtxja5i9	86	26	88	88	CD
cord-320331-wtxja5i9	86	27	]	]	-RRB-
cord-320331-wtxja5i9	86	28	.	.	.
cord-320331-wtxja5i9	87	1	STZ	stz	NN
cord-320331-wtxja5i9	87	2	-	-	HYPH
cord-320331-wtxja5i9	87	3	treated	treat	VBN
cord-320331-wtxja5i9	87	4	rats	rat	NNS
cord-320331-wtxja5i9	87	5	in	in	IN
cord-320331-wtxja5i9	87	6	previous	previous	JJ
cord-320331-wtxja5i9	87	7	experiments	experiment	NNS
cord-320331-wtxja5i9	87	8	were	be	VBD
cord-320331-wtxja5i9	87	9	found	find	VBN
cord-320331-wtxja5i9	87	10	to	to	TO
cord-320331-wtxja5i9	87	11	have	have	VB
cord-320331-wtxja5i9	87	12	higher	high	JJR
cord-320331-wtxja5i9	88	1	ACE	ACE	NNP
cord-320331-wtxja5i9	88	2	mRNA	mRNA	NNP
cord-320331-wtxja5i9	88	3	/	/	SYM
cord-320331-wtxja5i9	88	4	ACE2	ACE2	NNP
cord-320331-wtxja5i9	88	5	mRNA	mrna	NN
cord-320331-wtxja5i9	89	1	ratio	ratio	NN
cord-320331-wtxja5i9	89	2	,	,	,
cord-320331-wtxja5i9	89	3	a	a	DT
cord-320331-wtxja5i9	89	4	marker	marker	NN
cord-320331-wtxja5i9	89	5	of	of	IN
cord-320331-wtxja5i9	89	6	kidney	kidney	NN
cord-320331-wtxja5i9	89	7	damage	damage	NN
cord-320331-wtxja5i9	89	8	that	that	WDT
cord-320331-wtxja5i9	89	9	resulted	result	VBD
cord-320331-wtxja5i9	89	10	in	in	IN
cord-320331-wtxja5i9	89	11	renal	renal	JJ
cord-320331-wtxja5i9	89	12	injury	injury	NN
cord-320331-wtxja5i9	89	13	similar	similar	JJ
cord-320331-wtxja5i9	89	14	to	to	IN
cord-320331-wtxja5i9	89	15	human	human	JJ
cord-320331-wtxja5i9	89	16	diabetic	diabetic	JJ
cord-320331-wtxja5i9	89	17	nephropathy	nephropathy	NN
cord-320331-wtxja5i9	89	18	[	[	-LRB-
cord-320331-wtxja5i9	89	19	89	89	CD
cord-320331-wtxja5i9	89	20	,	,	,
cord-320331-wtxja5i9	89	21	90	90	CD
cord-320331-wtxja5i9	89	22	]	]	-RRB-
cord-320331-wtxja5i9	89	23	.	.	.
cord-320331-wtxja5i9	90	1	Due	due	IN
cord-320331-wtxja5i9	90	2	to	to	IN
cord-320331-wtxja5i9	90	3	a	a	DT
cord-320331-wtxja5i9	90	4	higher	high	JJR
cord-320331-wtxja5i9	90	5	ACE	ACE	NNP
cord-320331-wtxja5i9	90	6	/	/	SYM
cord-320331-wtxja5i9	90	7	ACE2	ACE2	NNP
cord-320331-wtxja5i9	90	8	ratio	ratio	NN
cord-320331-wtxja5i9	90	9	,	,	,
cord-320331-wtxja5i9	90	10	there	there	EX
cord-320331-wtxja5i9	90	11	was	be	VBD
cord-320331-wtxja5i9	90	12	less	less	JJR
cord-320331-wtxja5i9	90	13	Ang-	Ang-	NNS
cord-320331-wtxja5i9	91	1	(	(	-LRB-
cord-320331-wtxja5i9	91	2	1	1	CD
cord-320331-wtxja5i9	91	3	-	-	SYM
cord-320331-wtxja5i9	91	4	7	7	CD
cord-320331-wtxja5i9	91	5	)	)	-RRB-
cord-320331-wtxja5i9	91	6	synthesized	synthesize	VBN
cord-320331-wtxja5i9	91	7	in	in	IN
cord-320331-wtxja5i9	91	8	the	the	DT
cord-320331-wtxja5i9	91	9	kidney	kidney	NN
cord-320331-wtxja5i9	91	10	,	,	,
cord-320331-wtxja5i9	91	11	which	which	WDT
cord-320331-wtxja5i9	91	12	can	can	MD
cord-320331-wtxja5i9	91	13	effectively	effectively	RB
cord-320331-wtxja5i9	91	14	eliminate	eliminate	VB
cord-320331-wtxja5i9	91	15	its	-PRON-	PRP$
cord-320331-wtxja5i9	91	16	renoprotective	renoprotective	NN
cord-320331-wtxja5i9	91	17	effects	effect	NNS
cord-320331-wtxja5i9	91	18	[	[	-LRB-
cord-320331-wtxja5i9	91	19	88	88	CD
cord-320331-wtxja5i9	91	20	]	]	-RRB-
cord-320331-wtxja5i9	91	21	.	.	.
cord-320331-wtxja5i9	92	1	In	in	IN
cord-320331-wtxja5i9	92	2	an	an	DT
cord-320331-wtxja5i9	92	3	experimental	experimental	JJ
cord-320331-wtxja5i9	92	4	study	study	NN
cord-320331-wtxja5i9	92	5	using	use	VBG
cord-320331-wtxja5i9	92	6	C57BL	c57bl	NN
cord-320331-wtxja5i9	92	7	/	/	SYM
cord-320331-wtxja5i9	92	8	L	l	NN
cord-320331-wtxja5i9	92	9	mice	mice	NN
cord-320331-wtxja5i9	92	10	models	model	NNS
cord-320331-wtxja5i9	92	11	,	,	,
cord-320331-wtxja5i9	92	12	investigators	investigator	NNS
cord-320331-wtxja5i9	92	13	compared	compare	VBD
cord-320331-wtxja5i9	92	14	the	the	DT
cord-320331-wtxja5i9	92	15	physiology	physiology	NN
cord-320331-wtxja5i9	92	16	of	of	IN
cord-320331-wtxja5i9	92	17	normal	normal	JJ
cord-320331-wtxja5i9	92	18	20	20	CD
cord-320331-wtxja5i9	92	19	-	-	SYM
cord-320331-wtxja5i9	92	20	22	22	CD
cord-320331-wtxja5i9	92	21	week	week	NN
cord-320331-wtxja5i9	92	22	-	-	HYPH
cord-320331-wtxja5i9	92	23	old	old	JJ
cord-320331-wtxja5i9	92	24	C57BL/6	C57BL/6	NNP
cord-320331-wtxja5i9	92	25	mice	mouse	NNS
cord-320331-wtxja5i9	92	26	against	against	IN
cord-320331-wtxja5i9	92	27	ACE2	ACE2	NNP
cord-320331-wtxja5i9	92	28	-/y	-/y	NN
cord-320331-wtxja5i9	92	29	mice	mouse	NNS
cord-320331-wtxja5i9	92	30	which	which	WDT
cord-320331-wtxja5i9	92	31	lacked	lack	VBD
cord-320331-wtxja5i9	92	32	ACE2	ACE2	NNP
cord-320331-wtxja5i9	92	33	expression	expression	NN
cord-320331-wtxja5i9	92	34	.	.	.
cord-320331-wtxja5i9	93	1	The	the	DT
cord-320331-wtxja5i9	93	2	eNOS	enos	JJ
cord-320331-wtxja5i9	93	3	expression	expression	NN
cord-320331-wtxja5i9	93	4	in	in	IN
cord-320331-wtxja5i9	93	5	both	both	CC
cord-320331-wtxja5i9	93	6	protein	protein	NN
cord-320331-wtxja5i9	93	7	and	and	CC
cord-320331-wtxja5i9	93	8	mRNA	mrna	NN
cord-320331-wtxja5i9	93	9	levels	level	NNS
cord-320331-wtxja5i9	93	10	and	and	CC
cord-320331-wtxja5i9	93	11	NO	no	DT
cord-320331-wtxja5i9	93	12	concentrations	concentration	NNS
cord-320331-wtxja5i9	93	13	in	in	IN
cord-320331-wtxja5i9	93	14	the	the	DT
cord-320331-wtxja5i9	93	15	aortas	aorta	NNS
cord-320331-wtxja5i9	93	16	of	of	IN
cord-320331-wtxja5i9	93	17	ACE2	ACE2	NNP
cord-320331-wtxja5i9	94	1	-/y	-/y	NN
cord-320331-wtxja5i9	94	2	mice	mouse	NNS
cord-320331-wtxja5i9	94	3	were	be	VBD
cord-320331-wtxja5i9	94	4	decreased	decrease	VBN
cord-320331-wtxja5i9	94	5	,	,	,
cord-320331-wtxja5i9	94	6	along	along	IN
cord-320331-wtxja5i9	94	7	with	with	IN
cord-320331-wtxja5i9	94	8	urine	urine	NN
cord-320331-wtxja5i9	94	9	and	and	CC
cord-320331-wtxja5i9	94	10	plasma	plasma	NN
cord-320331-wtxja5i9	94	11	nitrite	nitrite	NN
cord-320331-wtxja5i9	94	12	concentration	concentration	NN
cord-320331-wtxja5i9	94	13	.	.	.
cord-320331-wtxja5i9	95	1	On	on	IN
cord-320331-wtxja5i9	95	2	the	the	DT
cord-320331-wtxja5i9	95	3	other	other	JJ
cord-320331-wtxja5i9	95	4	hand	hand	NN
cord-320331-wtxja5i9	95	5	,	,	,
cord-320331-wtxja5i9	95	6	lipid	lipid	NN
cord-320331-wtxja5i9	95	7	peroxidation	peroxidation	NN
cord-320331-wtxja5i9	95	8	was	be	VBD
cord-320331-wtxja5i9	95	9	markedly	markedly	RB
cord-320331-wtxja5i9	95	10	increased	increase	VBN
cord-320331-wtxja5i9	95	11	,	,	,
cord-320331-wtxja5i9	95	12	in	in	IN
cord-320331-wtxja5i9	95	13	contrast	contrast	NN
cord-320331-wtxja5i9	95	14	to	to	IN
cord-320331-wtxja5i9	95	15	a	a	DT
cord-320331-wtxja5i9	95	16	decreased	decreased	JJ
cord-320331-wtxja5i9	95	17	superoxide	superoxide	NN
cord-320331-wtxja5i9	95	18	dismutase	dismutase	NN
cord-320331-wtxja5i9	95	19	level	level	NN
cord-320331-wtxja5i9	95	20	in	in	IN
cord-320331-wtxja5i9	95	21	the	the	DT
cord-320331-wtxja5i9	95	22	aorta	aorta	JJ
cord-320331-wtxja5i9	95	23	homogenates	homogenate	NNS
cord-320331-wtxja5i9	95	24	of	of	IN
cord-320331-wtxja5i9	95	25	ACE2	ACE2	NNP
cord-320331-wtxja5i9	96	1	-/y	-/y	NN
cord-320331-wtxja5i9	96	2	mice	mice	NN
cord-320331-wtxja5i9	96	3	subjects	subject	NNS
cord-320331-wtxja5i9	96	4	-an	-an	:
cord-320331-wtxja5i9	96	5	indication	indication	NN
cord-320331-wtxja5i9	96	6	of	of	IN
cord-320331-wtxja5i9	96	7	impaired	impaired	JJ
cord-320331-wtxja5i9	96	8	antioxidant	antioxidant	NN
cord-320331-wtxja5i9	96	9	activity	activity	NN
cord-320331-wtxja5i9	96	10	leading	lead	VBG
cord-320331-wtxja5i9	96	11	to	to	IN
cord-320331-wtxja5i9	96	12	the	the	DT
cord-320331-wtxja5i9	96	13	formation	formation	NN
cord-320331-wtxja5i9	96	14	of	of	IN
cord-320331-wtxja5i9	96	15	reactive	reactive	JJ
cord-320331-wtxja5i9	96	16	oxygen	oxygen	NN
cord-320331-wtxja5i9	96	17	species	specie	NNS
cord-320331-wtxja5i9	96	18	(	(	-LRB-
cord-320331-wtxja5i9	96	19	ROS	ROS	NNP
cord-320331-wtxja5i9	96	20	)	)	-RRB-
cord-320331-wtxja5i9	97	1	[	[	-LRB-
cord-320331-wtxja5i9	97	2	92	92	CD
cord-320331-wtxja5i9	97	3	]	]	-RRB-
cord-320331-wtxja5i9	98	1	and	and	CC
cord-320331-wtxja5i9	98	2	observed	observe	VBD
cord-320331-wtxja5i9	98	3	vascular	vascular	JJ
cord-320331-wtxja5i9	98	4	dysfunction	dysfunction	NN
cord-320331-wtxja5i9	98	5	in	in	IN
cord-320331-wtxja5i9	98	6	ACE2-negative	ACE2-negative	NNP
cord-320331-wtxja5i9	98	7	C57BL/6	C57BL/6	NNP
cord-320331-wtxja5i9	98	8	mice	mouse	NNS
cord-320331-wtxja5i9	98	9	[	[	-LRB-
cord-320331-wtxja5i9	98	10	91	91	CD
cord-320331-wtxja5i9	98	11	]	]	-RRB-
cord-320331-wtxja5i9	98	12	.	.	.
cord-320331-wtxja5i9	99	1	Disturbances	disturbance	NNS
cord-320331-wtxja5i9	99	2	in	in	IN
cord-320331-wtxja5i9	99	3	the	the	DT
cord-320331-wtxja5i9	99	4	oxidative	oxidative	JJ
cord-320331-wtxja5i9	99	5	activity	activity	NN
cord-320331-wtxja5i9	99	6	of	of	IN
cord-320331-wtxja5i9	99	7	the	the	DT
cord-320331-wtxja5i9	99	8	vascular	vascular	JJ
cord-320331-wtxja5i9	99	9	system	system	NN
cord-320331-wtxja5i9	99	10	could	could	MD
cord-320331-wtxja5i9	99	11	pose	pose	VB
cord-320331-wtxja5i9	99	12	a	a	DT
cord-320331-wtxja5i9	99	13	risk	risk	NN
cord-320331-wtxja5i9	99	14	for	for	IN
cord-320331-wtxja5i9	99	15	acquiring	acquire	VBG
cord-320331-wtxja5i9	99	16	inflammation	inflammation	NN
cord-320331-wtxja5i9	99	17	,	,	,
cord-320331-wtxja5i9	99	18	vascular	vascular	JJ
cord-320331-wtxja5i9	99	19	remodelling	remodelling	NN
cord-320331-wtxja5i9	99	20	and	and	CC
cord-320331-wtxja5i9	99	21	vascular	vascular	JJ
cord-320331-wtxja5i9	99	22	injury	injury	NN
cord-320331-wtxja5i9	99	23	,	,	,
cord-320331-wtxja5i9	99	24	eventually	eventually	RB
cord-320331-wtxja5i9	99	25	leading	lead	VBG
cord-320331-wtxja5i9	99	26	to	to	IN
cord-320331-wtxja5i9	99	27	activation	activation	NN
cord-320331-wtxja5i9	99	28	of	of	IN
cord-320331-wtxja5i9	99	29	the	the	DT
cord-320331-wtxja5i9	99	30	coagulation	coagulation	NN
cord-320331-wtxja5i9	99	31	cascade	cascade	NN
cord-320331-wtxja5i9	99	32	that	that	WDT
cord-320331-wtxja5i9	99	33	could	could	MD
cord-320331-wtxja5i9	99	34	cause	cause	VB
cord-320331-wtxja5i9	99	35	microthrombi	microthrombi	NNP
cord-320331-wtxja5i9	99	36	formation	formation	NN
cord-320331-wtxja5i9	99	37	[	[	-LRB-
cord-320331-wtxja5i9	99	38	92	92	CD
cord-320331-wtxja5i9	99	39	,	,	,
cord-320331-wtxja5i9	99	40	115	115	CD
cord-320331-wtxja5i9	99	41	]	]	-RRB-
cord-320331-wtxja5i9	99	42	.	.	.
cord-320331-wtxja5i9	100	1	Taken	take	VBN
cord-320331-wtxja5i9	100	2	together	together	RB
cord-320331-wtxja5i9	100	3	,	,	,
cord-320331-wtxja5i9	100	4	these	these	DT
cord-320331-wtxja5i9	100	5	correlate	correlate	VBP
cord-320331-wtxja5i9	100	6	to	to	IN
cord-320331-wtxja5i9	100	7	the	the	DT
cord-320331-wtxja5i9	100	8	negative	negative	JJ
cord-320331-wtxja5i9	100	9	consequences	consequence	NNS
cord-320331-wtxja5i9	100	10	impacting	impact	VBG
cord-320331-wtxja5i9	100	11	the	the	DT
cord-320331-wtxja5i9	100	12	vascular	vascular	JJ
cord-320331-wtxja5i9	100	13	homeostasis	homeostasis	NN
cord-320331-wtxja5i9	100	14	of	of	IN
cord-320331-wtxja5i9	100	15	SARS	SARS	NNP
cord-320331-wtxja5i9	100	16	-	-	HYPH
cord-320331-wtxja5i9	100	17	CoV-2-induced	cov-2-induce	VBN
cord-320331-wtxja5i9	100	18	ACE2	ACE2	NNP
cord-320331-wtxja5i9	100	19	deficiency	deficiency	NN
cord-320331-wtxja5i9	100	20	,	,	,
cord-320331-wtxja5i9	100	21	with	with	IN
cord-320331-wtxja5i9	100	22	partial	partial	JJ
cord-320331-wtxja5i9	100	23	relations	relation	NNS
cord-320331-wtxja5i9	100	24	to	to	IN
cord-320331-wtxja5i9	100	25	the	the	DT
cord-320331-wtxja5i9	100	26	renin	renin	NN
cord-320331-wtxja5i9	100	27	-	-	HYPH
cord-320331-wtxja5i9	100	28	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	100	29	-	-	HYPH
cord-320331-wtxja5i9	100	30	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	100	31	system	system	NN
cord-320331-wtxja5i9	100	32	(	(	-LRB-
cord-320331-wtxja5i9	100	33	RAAS	RAAS	NNP
cord-320331-wtxja5i9	100	34	)	)	-RRB-
cord-320331-wtxja5i9	100	35	,	,	,
cord-320331-wtxja5i9	100	36	which	which	WDT
cord-320331-wtxja5i9	100	37	will	will	MD
cord-320331-wtxja5i9	100	38	be	be	VB
cord-320331-wtxja5i9	100	39	discussed	discuss	VBN
cord-320331-wtxja5i9	100	40	.	.	.
cord-320331-wtxja5i9	101	1	J	J	NNP
cord-320331-wtxja5i9	101	2	o	o	NN
cord-320331-wtxja5i9	101	3	u	u	NN
cord-320331-wtxja5i9	101	4	r	r	NN
cord-320331-wtxja5i9	101	5	n	n	NN
cord-320331-wtxja5i9	101	6	a	a	DT
cord-320331-wtxja5i9	101	7	l	l	NN
cord-320331-wtxja5i9	101	8	P	p	NN
cord-320331-wtxja5i9	101	9	r	r	NN
cord-320331-wtxja5i9	101	10	e	e	NN
cord-320331-wtxja5i9	102	1	-p	-p	:
cord-320331-wtxja5i9	103	1	r	r	NN
cord-320331-wtxja5i9	103	2	o	o	NN
cord-320331-wtxja5i9	103	3	o	o	NN
cord-320331-wtxja5i9	103	4	f	f	NN
cord-320331-wtxja5i9	103	5	A	a	DT
cord-320331-wtxja5i9	103	6	correspondence	correspondence	NN
cord-320331-wtxja5i9	103	7	by	by	IN
cord-320331-wtxja5i9	103	8	Fang	Fang	NNP
cord-320331-wtxja5i9	103	9	et	et	FW
cord-320331-wtxja5i9	103	10	al	al	NNP
cord-320331-wtxja5i9	103	11	published	publish	VBD
cord-320331-wtxja5i9	103	12	at	at	IN
cord-320331-wtxja5i9	103	13	The	the	DT
cord-320331-wtxja5i9	103	14	Lancet	Lancet	NNP
cord-320331-wtxja5i9	103	15	this	this	DT
cord-320331-wtxja5i9	103	16	March	March	NNP
cord-320331-wtxja5i9	103	17	discussed	discuss	VBD
cord-320331-wtxja5i9	103	18	that	that	IN
cord-320331-wtxja5i9	103	19	hypertensives	hypertensives	NNP
cord-320331-wtxja5i9	103	20	and	and	CC
cord-320331-wtxja5i9	103	21	diabetics	diabetic	NNS
cord-320331-wtxja5i9	103	22	taking	take	VBG
cord-320331-wtxja5i9	103	23	ACE2	ACE2	NNP
cord-320331-wtxja5i9	103	24	inhibitor	inhibitor	NN
cord-320331-wtxja5i9	103	25	(	(	-LRB-
cord-320331-wtxja5i9	103	26	ACEi	ACEi	NNP
cord-320331-wtxja5i9	103	27	)	)	-RRB-
cord-320331-wtxja5i9	103	28	and	and	CC
cord-320331-wtxja5i9	103	29	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	103	30	receptor	receptor	NN
cord-320331-wtxja5i9	103	31	blocking	block	VBG
cord-320331-wtxja5i9	104	1	(	(	-LRB-
cord-320331-wtxja5i9	104	2	ARB	ARB	NNP
cord-320331-wtxja5i9	104	3	)	)	-RRB-
cord-320331-wtxja5i9	104	4	drugs	drug	NNS
cord-320331-wtxja5i9	104	5	may	may	MD
cord-320331-wtxja5i9	104	6	be	be	VB
cord-320331-wtxja5i9	104	7	at	at	IN
cord-320331-wtxja5i9	104	8	an	an	DT
cord-320331-wtxja5i9	104	9	increased	increase	VBN
cord-320331-wtxja5i9	104	10	risk	risk	NN
cord-320331-wtxja5i9	104	11	of	of	IN
cord-320331-wtxja5i9	104	12	infection	infection	NN
cord-320331-wtxja5i9	104	13	and	and	CC
cord-320331-wtxja5i9	104	14	severity	severity	NN
cord-320331-wtxja5i9	104	15	by	by	IN
cord-320331-wtxja5i9	104	16	SARS	SARS	NNP
cord-320331-wtxja5i9	104	17	-	-	HYPH
cord-320331-wtxja5i9	104	18	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	104	19	and	and	CC
cord-320331-wtxja5i9	104	20	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	104	21	,	,	,
cord-320331-wtxja5i9	104	22	respectively	respectively	RB
cord-320331-wtxja5i9	104	23	,	,	,
cord-320331-wtxja5i9	104	24	citing	cite	VBG
cord-320331-wtxja5i9	104	25	three	three	CD
cord-320331-wtxja5i9	104	26	studies	study	NNS
cord-320331-wtxja5i9	104	27	wherein	wherein	VBZ
cord-320331-wtxja5i9	104	28	diabetes	diabetes	NN
cord-320331-wtxja5i9	104	29	and	and	CC
cord-320331-wtxja5i9	104	30	hypertension	hypertension	NN
cord-320331-wtxja5i9	104	31	were	be	VBD
cord-320331-wtxja5i9	104	32	major	major	JJ
cord-320331-wtxja5i9	104	33	comorbidities	comorbiditie	NNS
cord-320331-wtxja5i9	104	34	of	of	IN
cord-320331-wtxja5i9	104	35	patients	patient	NNS
cord-320331-wtxja5i9	104	36	with	with	IN
cord-320331-wtxja5i9	104	37	severe	severe	JJ
cord-320331-wtxja5i9	104	38	COVID-19	covid-19	NN
cord-320331-wtxja5i9	104	39	and	and	CC
cord-320331-wtxja5i9	104	40	of	of	IN
cord-320331-wtxja5i9	104	41	non	non	NNS
cord-320331-wtxja5i9	104	42	-	-	NNS
cord-320331-wtxja5i9	104	43	survivors	survivor	NNS
cord-320331-wtxja5i9	104	44	[	[	-LRB-
cord-320331-wtxja5i9	104	45	20	20	CD
cord-320331-wtxja5i9	104	46	]	]	-RRB-
cord-320331-wtxja5i9	104	47	.	.	.
cord-320331-wtxja5i9	105	1	Several	several	JJ
cord-320331-wtxja5i9	105	2	criticisms	criticism	NNS
cord-320331-wtxja5i9	105	3	were	be	VBD
cord-320331-wtxja5i9	105	4	received	receive	VBN
cord-320331-wtxja5i9	105	5	by	by	IN
cord-320331-wtxja5i9	105	6	this	this	DT
cord-320331-wtxja5i9	105	7	article	article	NN
cord-320331-wtxja5i9	105	8	,	,	,
cord-320331-wtxja5i9	105	9	mainly	mainly	RB
cord-320331-wtxja5i9	105	10	due	due	IN
cord-320331-wtxja5i9	105	11	to	to	IN
cord-320331-wtxja5i9	105	12	the	the	DT
cord-320331-wtxja5i9	105	13	lack	lack	NN
cord-320331-wtxja5i9	105	14	of	of	IN
cord-320331-wtxja5i9	105	15	clinical	clinical	JJ
cord-320331-wtxja5i9	105	16	evidence	evidence	NN
cord-320331-wtxja5i9	105	17	for	for	IN
cord-320331-wtxja5i9	105	18	many	many	JJ
cord-320331-wtxja5i9	105	19	of	of	IN
cord-320331-wtxja5i9	105	20	the	the	DT
cord-320331-wtxja5i9	105	21	author	author	NN
cord-320331-wtxja5i9	105	22	's	's	POS
cord-320331-wtxja5i9	105	23	claims	claim	NNS
cord-320331-wtxja5i9	105	24	at	at	IN
cord-320331-wtxja5i9	105	25	the	the	DT
cord-320331-wtxja5i9	105	26	time	time	NN
cord-320331-wtxja5i9	105	27	.	.	.
cord-320331-wtxja5i9	106	1	A	a	DT
cord-320331-wtxja5i9	106	2	descriptive	descriptive	JJ
cord-320331-wtxja5i9	106	3	study	study	NN
cord-320331-wtxja5i9	106	4	on	on	IN
cord-320331-wtxja5i9	106	5	the	the	DT
cord-320331-wtxja5i9	106	6	pharmacologic	pharmacologic	JJ
cord-320331-wtxja5i9	106	7	characteristics	characteristic	NNS
cord-320331-wtxja5i9	106	8	of	of	IN
cord-320331-wtxja5i9	106	9	96	96	CD
cord-320331-wtxja5i9	106	10	COVID-19	covid-19	CD
cord-320331-wtxja5i9	106	11	patients	patient	NNS
cord-320331-wtxja5i9	106	12	in	in	IN
cord-320331-wtxja5i9	106	13	the	the	DT
cord-320331-wtxja5i9	106	14	Toulouse	Toulouse	NNP
cord-320331-wtxja5i9	106	15	University	University	NNP
cord-320331-wtxja5i9	106	16	Hospital	Hospital	NNP
cord-320331-wtxja5i9	106	17	Intensive	Intensive	NNP
cord-320331-wtxja5i9	106	18	Care	Care	NNP
cord-320331-wtxja5i9	106	19	Unit	Unit	NNP
cord-320331-wtxja5i9	106	20	(	(	-LRB-
cord-320331-wtxja5i9	106	21	ICU	ICU	NNP
cord-320331-wtxja5i9	106	22	)	)	-RRB-
cord-320331-wtxja5i9	106	23	in	in	IN
cord-320331-wtxja5i9	106	24	France	France	NNP
cord-320331-wtxja5i9	106	25	showed	show	VBD
cord-320331-wtxja5i9	106	26	that	that	IN
cord-320331-wtxja5i9	106	27	many	many	JJ
cord-320331-wtxja5i9	106	28	of	of	IN
cord-320331-wtxja5i9	106	29	the	the	DT
cord-320331-wtxja5i9	106	30	patients	patient	NNS
cord-320331-wtxja5i9	106	31	who	who	WP
cord-320331-wtxja5i9	106	32	were	be	VBD
cord-320331-wtxja5i9	106	33	intubated	intubate	VBN
cord-320331-wtxja5i9	106	34	had	have	VBD
cord-320331-wtxja5i9	106	35	either	either	CC
cord-320331-wtxja5i9	106	36	taken	take	VBN
cord-320331-wtxja5i9	106	37	paracetamol	paracetamol	NNS
cord-320331-wtxja5i9	106	38	(	(	-LRB-
cord-320331-wtxja5i9	106	39	33.8	33.8	CD
cord-320331-wtxja5i9	106	40	%	%	NN
cord-320331-wtxja5i9	106	41	)	)	-RRB-
cord-320331-wtxja5i9	106	42	,	,	,
cord-320331-wtxja5i9	106	43	ARBs	arb	NNS
cord-320331-wtxja5i9	106	44	(	(	-LRB-
cord-320331-wtxja5i9	106	45	28.2	28.2	CD
cord-320331-wtxja5i9	106	46	)	)	-RRB-
cord-320331-wtxja5i9	106	47	,	,	,
cord-320331-wtxja5i9	106	48	calcium	calcium	NN
cord-320331-wtxja5i9	106	49	channel	channel	NN
cord-320331-wtxja5i9	106	50	blockers	blocker	NNS
cord-320331-wtxja5i9	106	51	(	(	-LRB-
cord-320331-wtxja5i9	106	52	15.5	15.5	CD
cord-320331-wtxja5i9	106	53	%	%	NN
cord-320331-wtxja5i9	106	54	)	)	-RRB-
cord-320331-wtxja5i9	106	55	,	,	,
cord-320331-wtxja5i9	106	56	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	106	57	(	(	-LRB-
cord-320331-wtxja5i9	106	58	15.5	15.5	CD
cord-320331-wtxja5i9	106	59	%	%	NN
cord-320331-wtxja5i9	106	60	)	)	-RRB-
cord-320331-wtxja5i9	106	61	,	,	,
cord-320331-wtxja5i9	106	62	or	or	CC
cord-320331-wtxja5i9	106	63	metformin	metformin	NNP
cord-320331-wtxja5i9	106	64	(	(	-LRB-
cord-320331-wtxja5i9	106	65	14.1	14.1	CD
cord-320331-wtxja5i9	106	66	%	%	NN
cord-320331-wtxja5i9	106	67	)	)	-RRB-
cord-320331-wtxja5i9	106	68	.	.	.
cord-320331-wtxja5i9	107	1	However	however	RB
cord-320331-wtxja5i9	107	2	,	,	,
cord-320331-wtxja5i9	107	3	these	these	DT
cord-320331-wtxja5i9	107	4	patients	patient	NNS
cord-320331-wtxja5i9	107	5	also	also	RB
cord-320331-wtxja5i9	107	6	had	have	VBD
cord-320331-wtxja5i9	107	7	pre	pre	VBN
cord-320331-wtxja5i9	107	8	-	-	JJ
cord-320331-wtxja5i9	107	9	existing	existing	JJ
cord-320331-wtxja5i9	107	10	co	co	JJ
cord-320331-wtxja5i9	107	11	-	-	JJ
cord-320331-wtxja5i9	107	12	morbid	morbid	JJ
cord-320331-wtxja5i9	107	13	conditions	condition	NNS
cord-320331-wtxja5i9	107	14	that	that	WDT
cord-320331-wtxja5i9	107	15	warranted	warrant	VBD
cord-320331-wtxja5i9	107	16	medication	medication	NN
cord-320331-wtxja5i9	107	17	intake	intake	NN
cord-320331-wtxja5i9	107	18	,	,	,
cord-320331-wtxja5i9	107	19	such	such	JJ
cord-320331-wtxja5i9	107	20	as	as	IN
cord-320331-wtxja5i9	107	21	obesity	obesity	NN
cord-320331-wtxja5i9	107	22	,	,	,
cord-320331-wtxja5i9	107	23	arterial	arterial	JJ
cord-320331-wtxja5i9	107	24	hypertension	hypertension	NN
cord-320331-wtxja5i9	107	25	,	,	,
cord-320331-wtxja5i9	107	26	and	and	CC
cord-320331-wtxja5i9	107	27	diabetes	diabetes	NN
cord-320331-wtxja5i9	107	28	mellitus	mellitus	NN
cord-320331-wtxja5i9	107	29	,	,	,
cord-320331-wtxja5i9	107	30	which	which	WDT
cord-320331-wtxja5i9	107	31	may	may	MD
cord-320331-wtxja5i9	107	32	regard	regard	VB
cord-320331-wtxja5i9	107	33	the	the	DT
cord-320331-wtxja5i9	107	34	evidence	evidence	NN
cord-320331-wtxja5i9	107	35	as	as	RB
cord-320331-wtxja5i9	107	36	coincidental	coincidental	JJ
cord-320331-wtxja5i9	107	37	at	at	IN
cord-320331-wtxja5i9	107	38	best	good	JJS
cord-320331-wtxja5i9	107	39	.	.	.
cord-320331-wtxja5i9	108	1	Since	since	IN
cord-320331-wtxja5i9	108	2	the	the	DT
cord-320331-wtxja5i9	108	3	study	study	NN
cord-320331-wtxja5i9	108	4	was	be	VBD
cord-320331-wtxja5i9	108	5	also	also	RB
cord-320331-wtxja5i9	108	6	descriptive	descriptive	JJ
cord-320331-wtxja5i9	108	7	(	(	-LRB-
cord-320331-wtxja5i9	108	8	case	case	NN
cord-320331-wtxja5i9	108	9	series	series	NNP
cord-320331-wtxja5i9	108	10	)	)	-RRB-
cord-320331-wtxja5i9	108	11	,	,	,
cord-320331-wtxja5i9	108	12	the	the	DT
cord-320331-wtxja5i9	108	13	results	result	NNS
cord-320331-wtxja5i9	108	14	and	and	CC
cord-320331-wtxja5i9	108	15	their	-PRON-	PRP$
cord-320331-wtxja5i9	108	16	implications	implication	NNS
cord-320331-wtxja5i9	108	17	can	can	MD
cord-320331-wtxja5i9	108	18	only	only	RB
cord-320331-wtxja5i9	108	19	be	be	VB
cord-320331-wtxja5i9	108	20	suggestive	suggestive	JJ
cord-320331-wtxja5i9	108	21	[	[	-LRB-
cord-320331-wtxja5i9	108	22	93	93	CD
cord-320331-wtxja5i9	108	23	]	]	-RRB-
cord-320331-wtxja5i9	108	24	.	.	.
cord-320331-wtxja5i9	109	1	However	however	RB
cord-320331-wtxja5i9	109	2	,	,	,
cord-320331-wtxja5i9	109	3	a	a	DT
cord-320331-wtxja5i9	109	4	drug	drug	NN
cord-320331-wtxja5i9	109	5	interaction	interaction	NN
cord-320331-wtxja5i9	109	6	can	can	MD
cord-320331-wtxja5i9	109	7	not	not	RB
cord-320331-wtxja5i9	109	8	be	be	VB
cord-320331-wtxja5i9	109	9	ruled	rule	VBN
cord-320331-wtxja5i9	109	10	out	out	RP
cord-320331-wtxja5i9	109	11	.	.	.
cord-320331-wtxja5i9	110	1	In	in	IN
cord-320331-wtxja5i9	110	2	terms	term	NNS
cord-320331-wtxja5i9	110	3	of	of	IN
cord-320331-wtxja5i9	110	4	the	the	DT
cord-320331-wtxja5i9	110	5	RAAS	raa	NNS
cord-320331-wtxja5i9	110	6	,	,	,
cord-320331-wtxja5i9	110	7	interaction	interaction	NN
cord-320331-wtxja5i9	110	8	between	between	IN
cord-320331-wtxja5i9	110	9	ARB	ARB	NNP
cord-320331-wtxja5i9	110	10	/	/	SYM
cord-320331-wtxja5i9	110	11	ACEi	acei	NN
cord-320331-wtxja5i9	110	12	drugs	drug	NNS
cord-320331-wtxja5i9	110	13	and	and	CC
cord-320331-wtxja5i9	110	14	viral	viral	JJ
cord-320331-wtxja5i9	110	15	entry	entry	NN
cord-320331-wtxja5i9	110	16	is	be	VBZ
cord-320331-wtxja5i9	110	17	plausible	plausible	JJ
cord-320331-wtxja5i9	110	18	,	,	,
cord-320331-wtxja5i9	110	19	since	since	IN
cord-320331-wtxja5i9	110	20	these	these	DT
cord-320331-wtxja5i9	110	21	drugs	drug	NNS
cord-320331-wtxja5i9	110	22	either	either	CC
cord-320331-wtxja5i9	110	23	inhibit	inhibit	VBP
cord-320331-wtxja5i9	110	24	ACE	ace	NN
cord-320331-wtxja5i9	110	25	or	or	CC
cord-320331-wtxja5i9	110	26	the	the	DT
cord-320331-wtxja5i9	110	27	receptor	receptor	NN
cord-320331-wtxja5i9	110	28	of	of	IN
cord-320331-wtxja5i9	110	29	its	-PRON-	PRP$
cord-320331-wtxja5i9	110	30	enzymatic	enzymatic	JJ
cord-320331-wtxja5i9	110	31	product	product	NN
cord-320331-wtxja5i9	110	32	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	110	33	II	II	NNP
cord-320331-wtxja5i9	110	34	,	,	,
cord-320331-wtxja5i9	110	35	and	and	CC
cord-320331-wtxja5i9	110	36	a	a	DT
cord-320331-wtxja5i9	110	37	known	know	VBN
cord-320331-wtxja5i9	110	38	physiologic	physiologic	JJ
cord-320331-wtxja5i9	110	39	response	response	NN
cord-320331-wtxja5i9	110	40	of	of	IN
cord-320331-wtxja5i9	110	41	cells	cell	NNS
cord-320331-wtxja5i9	110	42	to	to	IN
cord-320331-wtxja5i9	110	43	inhibition	inhibition	NN
cord-320331-wtxja5i9	110	44	or	or	CC
cord-320331-wtxja5i9	110	45	internalization	internalization	NN
cord-320331-wtxja5i9	111	1	is	be	VBZ
cord-320331-wtxja5i9	111	2	feedback	feedback	NN
cord-320331-wtxja5i9	111	3	upregulation	upregulation	NN
cord-320331-wtxja5i9	111	4	[	[	-LRB-
cord-320331-wtxja5i9	111	5	21	21	CD
cord-320331-wtxja5i9	111	6	]	]	-RRB-
cord-320331-wtxja5i9	111	7	.	.	.
cord-320331-wtxja5i9	112	1	Since	since	IN
cord-320331-wtxja5i9	112	2	the	the	DT
cord-320331-wtxja5i9	112	3	known	know	VBN
cord-320331-wtxja5i9	112	4	human	human	JJ
cord-320331-wtxja5i9	112	5	receptor	receptor	NN
cord-320331-wtxja5i9	112	6	of	of	IN
cord-320331-wtxja5i9	112	7	SARS	SARS	NNP
cord-320331-wtxja5i9	112	8	-	-	HYPH
cord-320331-wtxja5i9	112	9	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	112	10	is	be	VBZ
cord-320331-wtxja5i9	112	11	ACE2	ACE2	NNP
cord-320331-wtxja5i9	112	12	,	,	,
cord-320331-wtxja5i9	112	13	then	then	RB
cord-320331-wtxja5i9	112	14	it	-PRON-	PRP
cord-320331-wtxja5i9	112	15	is	be	VBZ
cord-320331-wtxja5i9	112	16	possible	possible	JJ
cord-320331-wtxja5i9	112	17	for	for	IN
cord-320331-wtxja5i9	112	18	hypertensives	hypertensives	NNP
cord-320331-wtxja5i9	112	19	chronically	chronically	RB
cord-320331-wtxja5i9	112	20	taking	take	VBG
cord-320331-wtxja5i9	112	21	ACEis	aceis	NN
cord-320331-wtxja5i9	112	22	to	to	TO
cord-320331-wtxja5i9	112	23	be	be	VB
cord-320331-wtxja5i9	112	24	susceptible	susceptible	JJ
cord-320331-wtxja5i9	112	25	to	to	IN
cord-320331-wtxja5i9	112	26	SARS	SARS	NNP
cord-320331-wtxja5i9	112	27	-	-	HYPH
cord-320331-wtxja5i9	112	28	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	112	29	infection	infection	NN
cord-320331-wtxja5i9	112	30	,	,	,
cord-320331-wtxja5i9	112	31	if	if	IN
cord-320331-wtxja5i9	112	32	feedback	feedback	NN
cord-320331-wtxja5i9	112	33	upregulation	upregulation	NN
cord-320331-wtxja5i9	112	34	of	of	IN
cord-320331-wtxja5i9	112	35	ACE2	ACE2	NNP
cord-320331-wtxja5i9	112	36	expression	expression	NN
cord-320331-wtxja5i9	112	37	does	do	VBZ
cord-320331-wtxja5i9	112	38	occur	occur	VB
cord-320331-wtxja5i9	112	39	,	,	,
cord-320331-wtxja5i9	112	40	or	or	CC
cord-320331-wtxja5i9	112	41	due	due	IN
cord-320331-wtxja5i9	112	42	to	to	IN
cord-320331-wtxja5i9	112	43	the	the	DT
cord-320331-wtxja5i9	112	44	patients	patient	NNS
cord-320331-wtxja5i9	112	45	'	'	POS
cord-320331-wtxja5i9	112	46	impaired	impaired	JJ
cord-320331-wtxja5i9	112	47	ability	ability	NN
cord-320331-wtxja5i9	112	48	to	to	TO
cord-320331-wtxja5i9	112	49	decrease	decrease	VB
cord-320331-wtxja5i9	112	50	Ang	Ang	NNP
cord-320331-wtxja5i9	112	51	II	II	NNP
cord-320331-wtxja5i9	112	52	secondary	secondary	JJ
cord-320331-wtxja5i9	112	53	to	to	IN
cord-320331-wtxja5i9	112	54	renin	renin	NN
cord-320331-wtxja5i9	112	55	production	production	NN
cord-320331-wtxja5i9	112	56	,	,	,
cord-320331-wtxja5i9	112	57	all	all	DT
cord-320331-wtxja5i9	112	58	of	of	IN
cord-320331-wtxja5i9	112	59	which	which	WDT
cord-320331-wtxja5i9	112	60	may	may	MD
cord-320331-wtxja5i9	112	61	increase	increase	VB
cord-320331-wtxja5i9	112	62	membrane	membrane	NN
cord-320331-wtxja5i9	112	63	ACE2	ACE2	NNP
cord-320331-wtxja5i9	112	64	levels	level	NNS
cord-320331-wtxja5i9	112	65	[	[	-LRB-
cord-320331-wtxja5i9	112	66	22	22	CD
cord-320331-wtxja5i9	112	67	,	,	,
cord-320331-wtxja5i9	112	68	23	23	CD
cord-320331-wtxja5i9	112	69	]	]	-RRB-
cord-320331-wtxja5i9	113	1	(	(	-LRB-
cord-320331-wtxja5i9	113	2	Fig	Fig	NNP
cord-320331-wtxja5i9	113	3	.	.	NNP
cord-320331-wtxja5i9	113	4	1	1	CD
cord-320331-wtxja5i9	113	5	)	)	-RRB-
cord-320331-wtxja5i9	113	6	.	.	.
cord-320331-wtxja5i9	114	1	A	a	DT
cord-320331-wtxja5i9	114	2	similar	similar	JJ
cord-320331-wtxja5i9	114	3	pathway	pathway	NN
cord-320331-wtxja5i9	114	4	is	be	VBZ
cord-320331-wtxja5i9	114	5	expected	expect	VBN
cord-320331-wtxja5i9	114	6	for	for	IN
cord-320331-wtxja5i9	114	7	ARBs	arb	NNS
cord-320331-wtxja5i9	114	8	,	,	,
cord-320331-wtxja5i9	114	9	since	since	IN
cord-320331-wtxja5i9	114	10	inhibition	inhibition	NN
cord-320331-wtxja5i9	114	11	of	of	IN
cord-320331-wtxja5i9	114	12	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	114	13	receptors	receptor	NNS
cord-320331-wtxja5i9	114	14	can	can	MD
cord-320331-wtxja5i9	114	15	trigger	trigger	VB
cord-320331-wtxja5i9	114	16	a	a	DT
cord-320331-wtxja5i9	114	17	feedback	feedback	NN
cord-320331-wtxja5i9	114	18	mechanism	mechanism	NN
cord-320331-wtxja5i9	114	19	to	to	TO
cord-320331-wtxja5i9	114	20	increase	increase	VB
cord-320331-wtxja5i9	114	21	Ang	Ang	NNP
cord-320331-wtxja5i9	114	22	II	II	NNP
cord-320331-wtxja5i9	114	23	synthesis	synthesis	NN
cord-320331-wtxja5i9	114	24	resulting	result	VBG
cord-320331-wtxja5i9	114	25	to	to	IN
cord-320331-wtxja5i9	114	26	an	an	DT
cord-320331-wtxja5i9	114	27	upregulation	upregulation	NN
cord-320331-wtxja5i9	114	28	of	of	IN
cord-320331-wtxja5i9	114	29	ACE2	ACE2	NNP
cord-320331-wtxja5i9	114	30	expression	expression	NN
cord-320331-wtxja5i9	114	31	(	(	-LRB-
cord-320331-wtxja5i9	114	32	Fig	fig	NN
cord-320331-wtxja5i9	114	33	.	.	.
cord-320331-wtxja5i9	114	34	  	  	_SP
cord-320331-wtxja5i9	114	35	1	1	CD
cord-320331-wtxja5i9	114	36	)	)	-RRB-
cord-320331-wtxja5i9	114	37	,	,	,
cord-320331-wtxja5i9	114	38	and	and	CC
cord-320331-wtxja5i9	114	39	this	this	DT
cord-320331-wtxja5i9	114	40	has	have	VBZ
cord-320331-wtxja5i9	114	41	been	be	VBN
cord-320331-wtxja5i9	114	42	shown	show	VBN
cord-320331-wtxja5i9	114	43	in	in	IN
cord-320331-wtxja5i9	114	44	previous	previous	JJ
cord-320331-wtxja5i9	114	45	studies	study	NNS
cord-320331-wtxja5i9	114	46	[	[	-LRB-
cord-320331-wtxja5i9	114	47	22	22	CD
cord-320331-wtxja5i9	114	48	,	,	,
cord-320331-wtxja5i9	114	49	24	24	CD
cord-320331-wtxja5i9	114	50	,	,	,
cord-320331-wtxja5i9	114	51	25	25	CD
cord-320331-wtxja5i9	114	52	,	,	,
cord-320331-wtxja5i9	114	53	26	26	CD
cord-320331-wtxja5i9	114	54	]	]	-RRB-
cord-320331-wtxja5i9	114	55	.	.	.
cord-320331-wtxja5i9	115	1	Several	several	JJ
cord-320331-wtxja5i9	115	2	other	other	JJ
cord-320331-wtxja5i9	115	3	studies	study	NNS
cord-320331-wtxja5i9	115	4	have	have	VBP
cord-320331-wtxja5i9	115	5	since	since	IN
cord-320331-wtxja5i9	115	6	followed	follow	VBN
cord-320331-wtxja5i9	115	7	this	this	DT
cord-320331-wtxja5i9	115	8	hypothesis	hypothesis	NN
cord-320331-wtxja5i9	115	9	closely	closely	RB
cord-320331-wtxja5i9	115	10	,	,	,
cord-320331-wtxja5i9	115	11	and	and	CC
cord-320331-wtxja5i9	115	12	have	have	VBP
cord-320331-wtxja5i9	115	13	in	in	IN
cord-320331-wtxja5i9	115	14	the	the	DT
cord-320331-wtxja5i9	115	15	process	process	NN
cord-320331-wtxja5i9	115	16	unraveled	unravel	VBD
cord-320331-wtxja5i9	115	17	the	the	DT
cord-320331-wtxja5i9	115	18	role	role	NN
cord-320331-wtxja5i9	115	19	of	of	IN
cord-320331-wtxja5i9	115	20	the	the	DT
cord-320331-wtxja5i9	115	21	renin	renin	NN
cord-320331-wtxja5i9	115	22	-	-	HYPH
cord-320331-wtxja5i9	115	23	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	115	24	-	-	HYPH
cord-320331-wtxja5i9	115	25	J	J	NNP
cord-320331-wtxja5i9	115	26	o	o	NN
cord-320331-wtxja5i9	115	27	u	u	NN
cord-320331-wtxja5i9	115	28	r	r	NN
cord-320331-wtxja5i9	115	29	n	n	NN
cord-320331-wtxja5i9	115	30	a	a	DT
cord-320331-wtxja5i9	115	31	l	l	NN
cord-320331-wtxja5i9	115	32	P	p	NN
cord-320331-wtxja5i9	115	33	r	r	NN
cord-320331-wtxja5i9	115	34	e	e	NN
cord-320331-wtxja5i9	115	35	-p	-p	NN
cord-320331-wtxja5i9	115	36	r	r	NN
cord-320331-wtxja5i9	115	37	o	o	NN
cord-320331-wtxja5i9	115	38	o	o	NN
cord-320331-wtxja5i9	115	39	f	f	NN
cord-320331-wtxja5i9	115	40	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	115	41	system	system	NN
cord-320331-wtxja5i9	115	42	(	(	-LRB-
cord-320331-wtxja5i9	115	43	RAAS	RAAS	NNP
cord-320331-wtxja5i9	115	44	)	)	-RRB-
cord-320331-wtxja5i9	115	45	on	on	IN
cord-320331-wtxja5i9	115	46	the	the	DT
cord-320331-wtxja5i9	115	47	observed	observed	JJ
cord-320331-wtxja5i9	115	48	clinical	clinical	JJ
cord-320331-wtxja5i9	115	49	outcomes	outcome	NNS
cord-320331-wtxja5i9	115	50	of	of	IN
cord-320331-wtxja5i9	115	51	some	some	DT
cord-320331-wtxja5i9	115	52	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	115	53	patients	patient	NNS
cord-320331-wtxja5i9	115	54	,	,	,
cord-320331-wtxja5i9	115	55	albeit	albeit	IN
cord-320331-wtxja5i9	115	56	with	with	IN
cord-320331-wtxja5i9	115	57	a	a	DT
cord-320331-wtxja5i9	115	58	surprisingly	surprisingly	RB
cord-320331-wtxja5i9	115	59	different	different	JJ
cord-320331-wtxja5i9	115	60	mechanism	mechanism	NN
cord-320331-wtxja5i9	115	61	.	.	.
cord-320331-wtxja5i9	116	1	Two	two	CD
cord-320331-wtxja5i9	116	2	experimental	experimental	JJ
cord-320331-wtxja5i9	116	3	studies	study	NNS
cord-320331-wtxja5i9	116	4	,	,	,
cord-320331-wtxja5i9	116	5	one	one	CD
cord-320331-wtxja5i9	116	6	in	in	IN
cord-320331-wtxja5i9	116	7	silico	silico	NN
cord-320331-wtxja5i9	116	8	and	and	CC
cord-320331-wtxja5i9	116	9	another	another	DT
cord-320331-wtxja5i9	116	10	in	in	FW
cord-320331-wtxja5i9	116	11	vitro	vitro	FW
cord-320331-wtxja5i9	116	12	,	,	,
cord-320331-wtxja5i9	116	13	have	have	VBP
cord-320331-wtxja5i9	116	14	clarified	clarify	VBN
cord-320331-wtxja5i9	116	15	and	and	CC
cord-320331-wtxja5i9	116	16	suggested	suggest	VBD
cord-320331-wtxja5i9	116	17	the	the	DT
cord-320331-wtxja5i9	116	18	role	role	NN
cord-320331-wtxja5i9	116	19	of	of	IN
cord-320331-wtxja5i9	116	20	the	the	DT
cord-320331-wtxja5i9	116	21	RAAS	raa	NNS
cord-320331-wtxja5i9	116	22	,	,	,
cord-320331-wtxja5i9	116	23	as	as	IN
cord-320331-wtxja5i9	116	24	follows	follow	VBZ
cord-320331-wtxja5i9	116	25	.	.	.
cord-320331-wtxja5i9	117	1	An	an	DT
cord-320331-wtxja5i9	117	2	in	in	IN
cord-320331-wtxja5i9	117	3	silico	silico	NN
cord-320331-wtxja5i9	117	4	approach	approach	NN
cord-320331-wtxja5i9	117	5	,	,	,
cord-320331-wtxja5i9	117	6	which	which	WDT
cord-320331-wtxja5i9	117	7	utilized	utilize	VBD
cord-320331-wtxja5i9	117	8	the	the	DT
cord-320331-wtxja5i9	117	9	COXPRESdb	COXPRESdb	NNP
cord-320331-wtxja5i9	117	10	v7	v7	NNP
cord-320331-wtxja5i9	117	11	,	,	,
cord-320331-wtxja5i9	117	12	Kyoto	Kyoto	NNP
cord-320331-wtxja5i9	117	13	Encyclopedia	Encyclopedia	NNP
cord-320331-wtxja5i9	117	14	of	of	IN
cord-320331-wtxja5i9	117	15	Genes	Genes	NNPS
cord-320331-wtxja5i9	117	16	and	and	CC
cord-320331-wtxja5i9	117	17	Genomes	Genomes	NNPS
cord-320331-wtxja5i9	117	18	(	(	-LRB-
cord-320331-wtxja5i9	117	19	KEGG	KEGG	NNP
cord-320331-wtxja5i9	117	20	)	)	-RRB-
cord-320331-wtxja5i9	117	21	PATHWAY	pathway	NN
cord-320331-wtxja5i9	117	22	and	and	CC
cord-320331-wtxja5i9	117	23	THE	the	DT
cord-320331-wtxja5i9	117	24	HUMAN	HUMAN	NNP
cord-320331-wtxja5i9	117	25	PROTEIN	PROTEIN	NNP
cord-320331-wtxja5i9	117	26	ATLAS	ATLAS	NNP
cord-320331-wtxja5i9	117	27	databases	database	NNS
cord-320331-wtxja5i9	117	28	to	to	TO
cord-320331-wtxja5i9	117	29	determine	determine	VB
cord-320331-wtxja5i9	117	30	the	the	DT
cord-320331-wtxja5i9	117	31	co	co	NN
cord-320331-wtxja5i9	117	32	-	-	NN
cord-320331-wtxja5i9	117	33	expression	expression	NN
cord-320331-wtxja5i9	117	34	,	,	,
cord-320331-wtxja5i9	117	35	molecular	molecular	JJ
cord-320331-wtxja5i9	117	36	interactions	interaction	NNS
cord-320331-wtxja5i9	117	37	and	and	CC
cord-320331-wtxja5i9	117	38	organ	organ	NN
cord-320331-wtxja5i9	117	39	-	-	HYPH
cord-320331-wtxja5i9	117	40	specific	specific	JJ
cord-320331-wtxja5i9	117	41	expression	expression	NN
cord-320331-wtxja5i9	117	42	of	of	IN
cord-320331-wtxja5i9	117	43	ACE2	ACE2	NNP
cord-320331-wtxja5i9	117	44	,	,	,
cord-320331-wtxja5i9	117	45	neprilysin	neprilysin	NN
cord-320331-wtxja5i9	117	46	and	and	CC
cord-320331-wtxja5i9	117	47	carbonic	carbonic	JJ
cord-320331-wtxja5i9	117	48	anhydrase	anhydrase	NN
cord-320331-wtxja5i9	117	49	(	(	-LRB-
cord-320331-wtxja5i9	117	50	CA	CA	NNP
cord-320331-wtxja5i9	117	51	)	)	-RRB-
cord-320331-wtxja5i9	117	52	,	,	,
cord-320331-wtxja5i9	117	53	have	have	VBP
cord-320331-wtxja5i9	117	54	shown	show	VBN
cord-320331-wtxja5i9	117	55	that	that	IN
cord-320331-wtxja5i9	117	56	these	these	DT
cord-320331-wtxja5i9	117	57	three	three	CD
cord-320331-wtxja5i9	117	58	enzymes	enzyme	NNS
cord-320331-wtxja5i9	117	59	were	be	VBD
cord-320331-wtxja5i9	117	60	highly	highly	RB
cord-320331-wtxja5i9	117	61	coexpressed	coexpresse	VBN
cord-320331-wtxja5i9	117	62	in	in	IN
cord-320331-wtxja5i9	117	63	the	the	DT
cord-320331-wtxja5i9	117	64	local	local	JJ
cord-320331-wtxja5i9	117	65	RAS	RAS	NNP
cord-320331-wtxja5i9	117	66	,	,	,
cord-320331-wtxja5i9	117	67	with	with	IN
cord-320331-wtxja5i9	117	68	important	important	JJ
cord-320331-wtxja5i9	117	69	overlapping	overlapping	JJ
cord-320331-wtxja5i9	117	70	functions	function	NNS
cord-320331-wtxja5i9	117	71	on	on	IN
cord-320331-wtxja5i9	117	72	the	the	DT
cord-320331-wtxja5i9	117	73	production	production	NN
cord-320331-wtxja5i9	117	74	of	of	IN
cord-320331-wtxja5i9	117	75	Ang-(1	Ang-(1	NNP
cord-320331-wtxja5i9	117	76	-	-	HYPH
cord-320331-wtxja5i9	117	77	9	9	CD
cord-320331-wtxja5i9	117	78	)	)	-RRB-
cord-320331-wtxja5i9	117	79	and	and	CC
cord-320331-wtxja5i9	117	80	Ang-(1	Ang-(1	NNP
cord-320331-wtxja5i9	117	81	-	-	HYPH
cord-320331-wtxja5i9	117	82	7	7	CD
cord-320331-wtxja5i9	117	83	)	)	-RRB-
cord-320331-wtxja5i9	117	84	for	for	IN
cord-320331-wtxja5i9	117	85	the	the	DT
cord-320331-wtxja5i9	117	86	regulation	regulation	NN
cord-320331-wtxja5i9	117	87	of	of	IN
cord-320331-wtxja5i9	117	88	systemic	systemic	JJ
cord-320331-wtxja5i9	117	89	vascular	vascular	JJ
cord-320331-wtxja5i9	117	90	resistance	resistance	NN
cord-320331-wtxja5i9	117	91	and	and	CC
cord-320331-wtxja5i9	117	92	the	the	DT
cord-320331-wtxja5i9	117	93	conversion	conversion	NN
cord-320331-wtxja5i9	117	94	of	of	IN
cord-320331-wtxja5i9	117	95	CO	CO	NNP
cord-320331-wtxja5i9	117	96	2	2	CD
cord-320331-wtxja5i9	117	97	in	in	IN
cord-320331-wtxja5i9	117	98	times	time	NNS
cord-320331-wtxja5i9	117	99	of	of	IN
cord-320331-wtxja5i9	117	100	hypoxia	hypoxia	NN
cord-320331-wtxja5i9	117	101	.	.	.
cord-320331-wtxja5i9	118	1	Further	further	RB
cord-320331-wtxja5i9	118	2	,	,	,
cord-320331-wtxja5i9	118	3	the	the	DT
cord-320331-wtxja5i9	118	4	authors	author	NNS
cord-320331-wtxja5i9	118	5	found	find	VBD
cord-320331-wtxja5i9	118	6	that	that	IN
cord-320331-wtxja5i9	118	7	these	these	DT
cord-320331-wtxja5i9	118	8	enzymes	enzyme	NNS
cord-320331-wtxja5i9	118	9	were	be	VBD
cord-320331-wtxja5i9	118	10	most	most	RBS
cord-320331-wtxja5i9	118	11	likely	likely	JJ
cord-320331-wtxja5i9	118	12	co	co	VBD
cord-320331-wtxja5i9	118	13	-	-	VBN
cord-320331-wtxja5i9	118	14	expressed	express	VBN
cord-320331-wtxja5i9	118	15	at	at	IN
cord-320331-wtxja5i9	118	16	organs	organ	NNS
cord-320331-wtxja5i9	118	17	of	of	IN
cord-320331-wtxja5i9	118	18	interest	interest	NN
cord-320331-wtxja5i9	118	19	such	such	JJ
cord-320331-wtxja5i9	118	20	as	as	IN
cord-320331-wtxja5i9	118	21	digestive	digestive	JJ
cord-320331-wtxja5i9	118	22	,	,	,
cord-320331-wtxja5i9	118	23	renal	renal	JJ
cord-320331-wtxja5i9	118	24	,	,	,
cord-320331-wtxja5i9	118	25	respiratory	respiratory	JJ
cord-320331-wtxja5i9	118	26	,	,	,
cord-320331-wtxja5i9	118	27	and	and	CC
cord-320331-wtxja5i9	118	28	reproductive	reproductive	JJ
cord-320331-wtxja5i9	118	29	systems	system	NNS
cord-320331-wtxja5i9	118	30	,	,	,
cord-320331-wtxja5i9	118	31	with	with	IN
cord-320331-wtxja5i9	118	32	the	the	DT
cord-320331-wtxja5i9	118	33	exception	exception	NN
cord-320331-wtxja5i9	118	34	of	of	IN
cord-320331-wtxja5i9	118	35	CA	CA	NNP
cord-320331-wtxja5i9	118	36	which	which	WDT
cord-320331-wtxja5i9	118	37	is	be	VBZ
cord-320331-wtxja5i9	118	38	ubiquitous	ubiquitous	JJ
cord-320331-wtxja5i9	118	39	[	[	-LRB-
cord-320331-wtxja5i9	118	40	94	94	CD
cord-320331-wtxja5i9	118	41	]	]	-RRB-
cord-320331-wtxja5i9	118	42	.	.	.
cord-320331-wtxja5i9	119	1	Likewise	likewise	RB
cord-320331-wtxja5i9	119	2	,	,	,
cord-320331-wtxja5i9	119	3	an	an	DT
cord-320331-wtxja5i9	119	4	in	in	FW
cord-320331-wtxja5i9	119	5	vitro	vitro	FW
cord-320331-wtxja5i9	119	6	study	study	NN
cord-320331-wtxja5i9	119	7	showed	show	VBD
cord-320331-wtxja5i9	119	8	that	that	IN
cord-320331-wtxja5i9	119	9	lung	lung	NN
cord-320331-wtxja5i9	119	10	epithelial	epithelial	NN
cord-320331-wtxja5i9	119	11	cells	cell	NNS
cord-320331-wtxja5i9	119	12	infected	infect	VBN
cord-320331-wtxja5i9	119	13	with	with	IN
cord-320331-wtxja5i9	119	14	SARS	SARS	NNP
cord-320331-wtxja5i9	119	15	-	-	HYPH
cord-320331-wtxja5i9	119	16	CoV	CoV	NNP
cord-320331-wtxja5i9	119	17	expressed	express	VBD
cord-320331-wtxja5i9	119	18	11	11	CD
cord-320331-wtxja5i9	119	19	unique	unique	JJ
cord-320331-wtxja5i9	119	20	RAS	RAS	NNP
cord-320331-wtxja5i9	119	21	genes	gene	NNS
cord-320331-wtxja5i9	119	22	within	within	IN
cord-320331-wtxja5i9	119	23	a	a	DT
cord-320331-wtxja5i9	119	24	48-hr	48-hr	CD
cord-320331-wtxja5i9	119	25	period	period	NN
cord-320331-wtxja5i9	119	26	,	,	,
cord-320331-wtxja5i9	119	27	which	which	WDT
cord-320331-wtxja5i9	119	28	correlated	correlate	VBD
cord-320331-wtxja5i9	119	29	well	well	RB
cord-320331-wtxja5i9	119	30	with	with	IN
cord-320331-wtxja5i9	119	31	the	the	DT
cord-320331-wtxja5i9	119	32	time	time	NN
cord-320331-wtxja5i9	119	33	of	of	IN
cord-320331-wtxja5i9	119	34	viral	viral	JJ
cord-320331-wtxja5i9	119	35	infection	infection	NN
cord-320331-wtxja5i9	119	36	.	.	.
cord-320331-wtxja5i9	120	1	These	these	DT
cord-320331-wtxja5i9	120	2	genes	gene	NNS
cord-320331-wtxja5i9	120	3	were	be	VBD
cord-320331-wtxja5i9	120	4	divided	divide	VBN
cord-320331-wtxja5i9	120	5	into	into	IN
cord-320331-wtxja5i9	120	6	those	those	DT
cord-320331-wtxja5i9	120	7	that	that	WDT
cord-320331-wtxja5i9	120	8	were	be	VBD
cord-320331-wtxja5i9	120	9	significantly	significantly	RB
cord-320331-wtxja5i9	120	10	upregulated	upregulate	VBN
cord-320331-wtxja5i9	120	11	during	during	IN
cord-320331-wtxja5i9	120	12	first	first	JJ
cord-320331-wtxja5i9	120	13	24	24	CD
cord-320331-wtxja5i9	120	14	hrs	hrs	NN
cord-320331-wtxja5i9	120	15	(	(	-LRB-
cord-320331-wtxja5i9	120	16	ACE	ACE	NNP
cord-320331-wtxja5i9	120	17	,	,	,
cord-320331-wtxja5i9	120	18	ACE2	ACE2	NNP
cord-320331-wtxja5i9	120	19	,	,	,
cord-320331-wtxja5i9	120	20	insulin	insulin	NN
cord-320331-wtxja5i9	120	21	-	-	HYPH
cord-320331-wtxja5i9	120	22	like	like	JJ
cord-320331-wtxja5i9	120	23	growth	growth	NN
cord-320331-wtxja5i9	120	24	factor	factor	NN
cord-320331-wtxja5i9	120	25	2	2	CD
cord-320331-wtxja5i9	120	26	receptor	receptor	NN
cord-320331-wtxja5i9	120	27	(	(	-LRB-
cord-320331-wtxja5i9	120	28	IGF2R	IGF2R	''
cord-320331-wtxja5i9	120	29	)	)	-RRB-
cord-320331-wtxja5i9	120	30	,	,	,
cord-320331-wtxja5i9	120	31	angiotensinogen	angiotensinogen	NNP
cord-320331-wtxja5i9	120	32	(	(	-LRB-
cord-320331-wtxja5i9	120	33	AGT	AGT	NNP
cord-320331-wtxja5i9	120	34	)	)	-RRB-
cord-320331-wtxja5i9	120	35	,	,	,
cord-320331-wtxja5i9	120	36	epidermal	epidermal	JJ
cord-320331-wtxja5i9	120	37	growth	growth	NN
cord-320331-wtxja5i9	120	38	factor	factor	NN
cord-320331-wtxja5i9	120	39	receptor	receptor	NN
cord-320331-wtxja5i9	120	40	(	(	-LRB-
cord-320331-wtxja5i9	120	41	EGFR	EGFR	NNP
cord-320331-wtxja5i9	120	42	)	)	-RRB-
cord-320331-wtxja5i9	120	43	,	,	,
cord-320331-wtxja5i9	120	44	matrix	matrix	NN
cord-320331-wtxja5i9	120	45	metalloendopeptidase	metalloendopeptidase	NN
cord-320331-wtxja5i9	120	46	(	(	-LRB-
cord-320331-wtxja5i9	120	47	MME	MME	NNP
cord-320331-wtxja5i9	120	48	)	)	-RRB-
cord-320331-wtxja5i9	120	49	,	,	,
cord-320331-wtxja5i9	120	50	alanyl	alanyl	NNP
cord-320331-wtxja5i9	120	51	aminopeptidase	aminopeptidase	NN
cord-320331-wtxja5i9	120	52	(	(	-LRB-
cord-320331-wtxja5i9	120	53	ANPEP	ANPEP	NNP
cord-320331-wtxja5i9	120	54	)	)	-RRB-
cord-320331-wtxja5i9	120	55	)	)	-RRB-
cord-320331-wtxja5i9	120	56	and	and	CC
cord-320331-wtxja5i9	120	57	those	those	DT
cord-320331-wtxja5i9	120	58	that	that	WDT
cord-320331-wtxja5i9	120	59	were	be	VBD
cord-320331-wtxja5i9	120	60	significantly	significantly	RB
cord-320331-wtxja5i9	120	61	upregulated	upregulate	VBN
cord-320331-wtxja5i9	120	62	by	by	IN
cord-320331-wtxja5i9	120	63	the	the	DT
cord-320331-wtxja5i9	120	64	48th	48th	JJ
cord-320331-wtxja5i9	120	65	hr	hr	NN
cord-320331-wtxja5i9	120	66	(	(	-LRB-
cord-320331-wtxja5i9	120	67	arginyl	arginyl	NN
cord-320331-wtxja5i9	120	68	aminopeptidase	aminopeptidase	NN
cord-320331-wtxja5i9	120	69	(	(	-LRB-
cord-320331-wtxja5i9	120	70	ARPEP	ARPEP	NNP
cord-320331-wtxja5i9	120	71	)	)	-RRB-
cord-320331-wtxja5i9	120	72	,	,	,
cord-320331-wtxja5i9	120	73	EGFR	EGFR	NNP
cord-320331-wtxja5i9	120	74	,	,	,
cord-320331-wtxja5i9	120	75	ANPEP	ANPEP	NNP
cord-320331-wtxja5i9	120	76	,	,	,
cord-320331-wtxja5i9	120	77	neurolysin	neurolysin	NNPS
cord-320331-wtxja5i9	120	78	,	,	,
cord-320331-wtxja5i9	120	79	ACE2	ACE2	NNP
cord-320331-wtxja5i9	120	80	,	,	,
cord-320331-wtxja5i9	120	81	IGFR	IGFR	NNP
cord-320331-wtxja5i9	120	82	,	,	,
cord-320331-wtxja5i9	120	83	leucyl	leucyl	NNP
cord-320331-wtxja5i9	120	84	and	and	CC
cord-320331-wtxja5i9	120	85	cysteinyl	cysteinyl	NNP
cord-320331-wtxja5i9	120	86	aminopeptidase	aminopeptidase	NNP
cord-320331-wtxja5i9	120	87	(	(	-LRB-
cord-320331-wtxja5i9	120	88	LNPEP	LNPEP	NNP
cord-320331-wtxja5i9	120	89	)	)	-RRB-
cord-320331-wtxja5i9	120	90	and	and	CC
cord-320331-wtxja5i9	120	91	cathepsin	cathepsin	NN
cord-320331-wtxja5i9	120	92	D	D	NNP
cord-320331-wtxja5i9	120	93	)	)	-RRB-
cord-320331-wtxja5i9	120	94	,	,	,
cord-320331-wtxja5i9	120	95	all	all	DT
cord-320331-wtxja5i9	120	96	of	of	IN
cord-320331-wtxja5i9	120	97	which	which	WDT
cord-320331-wtxja5i9	120	98	has	have	VBZ
cord-320331-wtxja5i9	120	99	clearly	clearly	RB
cord-320331-wtxja5i9	120	100	shown	show	VBN
cord-320331-wtxja5i9	120	101	the	the	DT
cord-320331-wtxja5i9	120	102	early	early	JJ
cord-320331-wtxja5i9	120	103	response	response	NN
cord-320331-wtxja5i9	120	104	of	of	IN
cord-320331-wtxja5i9	120	105	the	the	DT
cord-320331-wtxja5i9	120	106	RAAS	RAAS	NNP
cord-320331-wtxja5i9	120	107	on	on	IN
cord-320331-wtxja5i9	120	108	SARS	SARS	NNP
cord-320331-wtxja5i9	120	109	infection	infection	NN
cord-320331-wtxja5i9	120	110	[	[	-LRB-
cord-320331-wtxja5i9	120	111	95	95	CD
cord-320331-wtxja5i9	120	112	]	]	-RRB-
cord-320331-wtxja5i9	120	113	.	.	.
cord-320331-wtxja5i9	121	1	Studies	study	NNS
cord-320331-wtxja5i9	121	2	have	have	VBP
cord-320331-wtxja5i9	121	3	also	also	RB
cord-320331-wtxja5i9	121	4	recently	recently	RB
cord-320331-wtxja5i9	121	5	reported	report	VBN
cord-320331-wtxja5i9	121	6	that	that	IN
cord-320331-wtxja5i9	121	7	cleavage	cleavage	NN
cord-320331-wtxja5i9	121	8	of	of	IN
cord-320331-wtxja5i9	121	9	ACE2	ACE2	NNP
cord-320331-wtxja5i9	121	10	due	due	IN
cord-320331-wtxja5i9	121	11	to	to	IN
cord-320331-wtxja5i9	121	12	the	the	DT
cord-320331-wtxja5i9	121	13	interactions	interaction	NNS
cord-320331-wtxja5i9	121	14	with	with	IN
cord-320331-wtxja5i9	121	15	the	the	DT
cord-320331-wtxja5i9	121	16	viral	viral	JJ
cord-320331-wtxja5i9	121	17	S	S	NNP
cord-320331-wtxja5i9	121	18	protein	protein	NN
cord-320331-wtxja5i9	121	19	leads	lead	VBZ
cord-320331-wtxja5i9	121	20	to	to	IN
cord-320331-wtxja5i9	121	21	inhibition	inhibition	NN
cord-320331-wtxja5i9	121	22	of	of	IN
cord-320331-wtxja5i9	121	23	ACE2	ACE2	NNP
cord-320331-wtxja5i9	121	24	function	function	NN
cord-320331-wtxja5i9	121	25	through	through	IN
cord-320331-wtxja5i9	121	26	the	the	DT
cord-320331-wtxja5i9	121	27	RAS	RAS	NNP
cord-320331-wtxja5i9	121	28	ACE	ACE	NNP
cord-320331-wtxja5i9	121	29	/	/	SYM
cord-320331-wtxja5i9	121	30	Ang	Ang	NNP
cord-320331-wtxja5i9	121	31	II	II	NNP
cord-320331-wtxja5i9	121	32	/	/	SYM
cord-320331-wtxja5i9	121	33	AT1a	AT1a	NNP
cord-320331-wtxja5i9	121	34	arm	arm	NN
cord-320331-wtxja5i9	121	35	[	[	-LRB-
cord-320331-wtxja5i9	121	36	61	61	CD
cord-320331-wtxja5i9	121	37	,	,	,
cord-320331-wtxja5i9	121	38	62	62	CD
cord-320331-wtxja5i9	121	39	]	]	-RRB-
cord-320331-wtxja5i9	121	40	.	.	.
cord-320331-wtxja5i9	122	1	Another	another	DT
cord-320331-wtxja5i9	122	2	study	study	NN
cord-320331-wtxja5i9	122	3	has	have	VBZ
cord-320331-wtxja5i9	122	4	suggested	suggest	VBN
cord-320331-wtxja5i9	122	5	that	that	IN
cord-320331-wtxja5i9	122	6	excessive	excessive	JJ
cord-320331-wtxja5i9	122	7	activation	activation	NN
cord-320331-wtxja5i9	122	8	of	of	IN
cord-320331-wtxja5i9	122	9	RAAS	RAAS	NNP
cord-320331-wtxja5i9	122	10	by	by	IN
cord-320331-wtxja5i9	122	11	SARS	SARS	NNP
cord-320331-wtxja5i9	122	12	-	-	HYPH
cord-320331-wtxja5i9	122	13	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	122	14	plays	play	VBZ
cord-320331-wtxja5i9	122	15	a	a	DT
cord-320331-wtxja5i9	122	16	role	role	NN
cord-320331-wtxja5i9	122	17	in	in	IN
cord-320331-wtxja5i9	122	18	the	the	DT
cord-320331-wtxja5i9	122	19	onset	onset	NN
cord-320331-wtxja5i9	122	20	of	of	IN
cord-320331-wtxja5i9	122	21	acute	acute	JJ
cord-320331-wtxja5i9	122	22	respiratory	respiratory	JJ
cord-320331-wtxja5i9	122	23	distress	distress	NN
cord-320331-wtxja5i9	122	24	syndrome	syndrome	NN
cord-320331-wtxja5i9	122	25	(	(	-LRB-
cord-320331-wtxja5i9	122	26	ARDS	ARDS	NNP
cord-320331-wtxja5i9	122	27	)	)	-RRB-
cord-320331-wtxja5i9	122	28	,	,	,
cord-320331-wtxja5i9	122	29	a	a	DT
cord-320331-wtxja5i9	122	30	severe	severe	JJ
cord-320331-wtxja5i9	122	31	form	form	NN
cord-320331-wtxja5i9	122	32	of	of	IN
cord-320331-wtxja5i9	122	33	acute	acute	JJ
cord-320331-wtxja5i9	122	34	lung	lung	NN
cord-320331-wtxja5i9	122	35	injury	injury	NN
cord-320331-wtxja5i9	122	36	[	[	-LRB-
cord-320331-wtxja5i9	122	37	63	63	CD
cord-320331-wtxja5i9	122	38	]	]	-RRB-
cord-320331-wtxja5i9	122	39	.	.	.
cord-320331-wtxja5i9	123	1	In	in	IN
cord-320331-wtxja5i9	123	2	the	the	DT
cord-320331-wtxja5i9	123	3	presence	presence	NN
cord-320331-wtxja5i9	123	4	of	of	IN
cord-320331-wtxja5i9	123	5	ARDS	ARDS	NNP
cord-320331-wtxja5i9	123	6	,	,	,
cord-320331-wtxja5i9	123	7	fluid	fluid	NN
cord-320331-wtxja5i9	123	8	builds	build	VBZ
cord-320331-wtxja5i9	123	9	up	up	RP
cord-320331-wtxja5i9	123	10	in	in	IN
cord-320331-wtxja5i9	123	11	the	the	DT
cord-320331-wtxja5i9	123	12	alveoli	alveolus	NNS
cord-320331-wtxja5i9	123	13	,	,	,
cord-320331-wtxja5i9	123	14	damaging	damage	VBG
cord-320331-wtxja5i9	123	15	the	the	DT
cord-320331-wtxja5i9	123	16	surfactant	surfactant	NN
cord-320331-wtxja5i9	123	17	and	and	CC
cord-320331-wtxja5i9	123	18	promoting	promote	VBG
cord-320331-wtxja5i9	123	19	inflammation	inflammation	NN
cord-320331-wtxja5i9	123	20	,	,	,
cord-320331-wtxja5i9	123	21	eventually	eventually	RB
cord-320331-wtxja5i9	123	22	leaving	leave	VBG
cord-320331-wtxja5i9	123	23	fibrotic	fibrotic	JJ
cord-320331-wtxja5i9	123	24	scars	scar	NNS
cord-320331-wtxja5i9	123	25	that	that	WDT
cord-320331-wtxja5i9	123	26	prevents	prevent	VBZ
cord-320331-wtxja5i9	123	27	complete	complete	JJ
cord-320331-wtxja5i9	123	28	oxygen	oxygen	NN
cord-320331-wtxja5i9	123	29	uptake	uptake	NN
cord-320331-wtxja5i9	123	30	.	.	.
cord-320331-wtxja5i9	124	1	It	-PRON-	PRP
cord-320331-wtxja5i9	124	2	is	be	VBZ
cord-320331-wtxja5i9	124	3	important	important	JJ
cord-320331-wtxja5i9	124	4	to	to	TO
cord-320331-wtxja5i9	124	5	note	note	VB
cord-320331-wtxja5i9	124	6	that	that	IN
cord-320331-wtxja5i9	124	7	the	the	DT
cord-320331-wtxja5i9	124	8	binding	binding	NN
cord-320331-wtxja5i9	124	9	of	of	IN
cord-320331-wtxja5i9	124	10	the	the	DT
cord-320331-wtxja5i9	124	11	SARS	SARS	NNP
cord-320331-wtxja5i9	124	12	-	-	HYPH
cord-320331-wtxja5i9	124	13	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	124	14	spike	spike	NN
cord-320331-wtxja5i9	124	15	RBD	rbd	NN
cord-320331-wtxja5i9	124	16	to	to	IN
cord-320331-wtxja5i9	124	17	ACE2	ACE2	NNP
cord-320331-wtxja5i9	124	18	effectively	effectively	RB
cord-320331-wtxja5i9	124	19	inhibits	inhibit	VBZ
cord-320331-wtxja5i9	124	20	J	J	NNP
cord-320331-wtxja5i9	124	21	o	o	NN
cord-320331-wtxja5i9	124	22	u	u	NN
cord-320331-wtxja5i9	124	23	r	r	NN
cord-320331-wtxja5i9	124	24	n	n	NN
cord-320331-wtxja5i9	124	25	a	a	DT
cord-320331-wtxja5i9	124	26	l	l	NN
cord-320331-wtxja5i9	124	27	P	p	NN
cord-320331-wtxja5i9	124	28	r	r	NN
cord-320331-wtxja5i9	124	29	e	e	NN
cord-320331-wtxja5i9	125	1	-p	-p	NNP
cord-320331-wtxja5i9	125	2	r	r	NN
cord-320331-wtxja5i9	125	3	o	o	NN
cord-320331-wtxja5i9	125	4	o	o	NN
cord-320331-wtxja5i9	125	5	f	f	NN
cord-320331-wtxja5i9	125	6	the	the	DT
cord-320331-wtxja5i9	125	7	enzyme	enzyme	NN
cord-320331-wtxja5i9	125	8	receptor	receptor	NN
cord-320331-wtxja5i9	125	9	,	,	,
cord-320331-wtxja5i9	125	10	leading	lead	VBG
cord-320331-wtxja5i9	125	11	to	to	IN
cord-320331-wtxja5i9	125	12	endocytosis	endocytosis	NN
cord-320331-wtxja5i9	125	13	and	and	CC
cord-320331-wtxja5i9	125	14	early	early	JJ
cord-320331-wtxja5i9	125	15	ACE2	ACE2	NNP
cord-320331-wtxja5i9	125	16	depletion	depletion	NN
cord-320331-wtxja5i9	125	17	.	.	.
cord-320331-wtxja5i9	126	1	This	this	DT
cord-320331-wtxja5i9	126	2	mechanism	mechanism	NN
cord-320331-wtxja5i9	126	3	,	,	,
cord-320331-wtxja5i9	126	4	which	which	WDT
cord-320331-wtxja5i9	126	5	can	can	MD
cord-320331-wtxja5i9	126	6	interact	interact	VB
cord-320331-wtxja5i9	126	7	with	with	IN
cord-320331-wtxja5i9	126	8	many	many	JJ
cord-320331-wtxja5i9	126	9	other	other	JJ
cord-320331-wtxja5i9	126	10	pathways	pathway	NNS
cord-320331-wtxja5i9	126	11	,	,	,
cord-320331-wtxja5i9	126	12	can	can	MD
cord-320331-wtxja5i9	126	13	also	also	RB
cord-320331-wtxja5i9	126	14	lead	lead	VB
cord-320331-wtxja5i9	126	15	to	to	IN
cord-320331-wtxja5i9	126	16	the	the	DT
cord-320331-wtxja5i9	126	17	onset	onset	NN
cord-320331-wtxja5i9	126	18	of	of	IN
cord-320331-wtxja5i9	126	19	ARDS	ARDS	NNP
cord-320331-wtxja5i9	126	20	,	,	,
cord-320331-wtxja5i9	126	21	by	by	IN
cord-320331-wtxja5i9	126	22	virtue	virtue	NN
cord-320331-wtxja5i9	126	23	of	of	IN
cord-320331-wtxja5i9	126	24	feedback	feedback	NN
cord-320331-wtxja5i9	126	25	activation	activation	NN
cord-320331-wtxja5i9	126	26	of	of	IN
cord-320331-wtxja5i9	126	27	the	the	DT
cord-320331-wtxja5i9	126	28	RAAS	raa	NNS
cord-320331-wtxja5i9	126	29	or	or	CC
cord-320331-wtxja5i9	126	30	by	by	IN
cord-320331-wtxja5i9	126	31	other	other	JJ
cord-320331-wtxja5i9	126	32	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	126	33	dependent	dependent	JJ
cord-320331-wtxja5i9	126	34	solely	solely	RB
cord-320331-wtxja5i9	126	35	on	on	IN
cord-320331-wtxja5i9	126	36	ACE2	ACE2	NNP
cord-320331-wtxja5i9	126	37	.	.	.
cord-320331-wtxja5i9	127	1	To	to	IN
cord-320331-wtxja5i9	127	2	date	date	NN
cord-320331-wtxja5i9	127	3	,	,	,
cord-320331-wtxja5i9	127	4	there	there	EX
cord-320331-wtxja5i9	127	5	seems	seem	VBZ
cord-320331-wtxja5i9	127	6	to	to	TO
cord-320331-wtxja5i9	127	7	be	be	VB
cord-320331-wtxja5i9	127	8	no	no	DT
cord-320331-wtxja5i9	127	9	sufficient	sufficient	JJ
cord-320331-wtxja5i9	127	10	clinical	clinical	JJ
cord-320331-wtxja5i9	127	11	evidence	evidence	NN
cord-320331-wtxja5i9	127	12	that	that	WDT
cord-320331-wtxja5i9	127	13	can	can	MD
cord-320331-wtxja5i9	127	14	confirm	confirm	VB
cord-320331-wtxja5i9	127	15	the	the	DT
cord-320331-wtxja5i9	127	16	biological	biological	JJ
cord-320331-wtxja5i9	127	17	relevance	relevance	NN
cord-320331-wtxja5i9	127	18	of	of	IN
cord-320331-wtxja5i9	127	19	these	these	DT
cord-320331-wtxja5i9	127	20	experimental	experimental	JJ
cord-320331-wtxja5i9	127	21	results	result	NNS
cord-320331-wtxja5i9	127	22	.	.	.
cord-320331-wtxja5i9	128	1	In	in	IN
cord-320331-wtxja5i9	128	2	a	a	DT
cord-320331-wtxja5i9	128	3	retrospective	retrospective	JJ
cord-320331-wtxja5i9	128	4	multicenter	multicenter	JJ
cord-320331-wtxja5i9	128	5	cohort	cohort	NN
cord-320331-wtxja5i9	128	6	study	study	NN
cord-320331-wtxja5i9	128	7	of	of	IN
cord-320331-wtxja5i9	128	8	154	154	CD
cord-320331-wtxja5i9	128	9	COVID-19-positive	covid-19-positive	JJ
cord-320331-wtxja5i9	128	10	geriatric	geriatric	JJ
cord-320331-wtxja5i9	128	11	patients	patient	NNS
cord-320331-wtxja5i9	128	12	in	in	IN
cord-320331-wtxja5i9	128	13	Belgian	belgian	JJ
cord-320331-wtxja5i9	128	14	nursing	nursing	NN
cord-320331-wtxja5i9	128	15	homes	home	NNS
cord-320331-wtxja5i9	128	16	,	,	,
cord-320331-wtxja5i9	128	17	a	a	DT
cord-320331-wtxja5i9	128	18	non	non	JJ
cord-320331-wtxja5i9	128	19	-	-	JJ
cord-320331-wtxja5i9	128	20	significant	significant	JJ
cord-320331-wtxja5i9	128	21	association	association	NN
cord-320331-wtxja5i9	128	22	was	be	VBD
cord-320331-wtxja5i9	128	23	observed	observe	VBN
cord-320331-wtxja5i9	128	24	between	between	IN
cord-320331-wtxja5i9	128	25	ARB	ARB	NNP
cord-320331-wtxja5i9	128	26	/	/	SYM
cord-320331-wtxja5i9	128	27	ACEi	acei	NN
cord-320331-wtxja5i9	128	28	use	use	NN
cord-320331-wtxja5i9	128	29	and	and	CC
cord-320331-wtxja5i9	128	30	severe	severe	JJ
cord-320331-wtxja5i9	128	31	or	or	CC
cord-320331-wtxja5i9	128	32	poor	poor	JJ
cord-320331-wtxja5i9	128	33	outcomes	outcome	NNS
cord-320331-wtxja5i9	128	34	(	(	-LRB-
cord-320331-wtxja5i9	128	35	OR	or	CC
cord-320331-wtxja5i9	128	36	0.48	0.48	CD
cord-320331-wtxja5i9	128	37	;	;	:
cord-320331-wtxja5i9	128	38	CI	CI	NNP
cord-320331-wtxja5i9	128	39	0.10	0.10	CD
cord-320331-wtxja5i9	128	40	-	-	HYPH
cord-320331-wtxja5i9	128	41	1.97	1.97	CD
cord-320331-wtxja5i9	128	42	)	)	-RRB-
cord-320331-wtxja5i9	128	43	[	[	-LRB-
cord-320331-wtxja5i9	128	44	96	96	CD
cord-320331-wtxja5i9	128	45	]	]	-RRB-
cord-320331-wtxja5i9	128	46	.	.	.
cord-320331-wtxja5i9	129	1	In	in	IN
cord-320331-wtxja5i9	129	2	another	another	DT
cord-320331-wtxja5i9	129	3	retrospective	retrospective	JJ
cord-320331-wtxja5i9	129	4	cohort	cohort	NN
cord-320331-wtxja5i9	129	5	study	study	NN
cord-320331-wtxja5i9	129	6	of	of	IN
cord-320331-wtxja5i9	129	7	117	117	CD
cord-320331-wtxja5i9	129	8	geriatric	geriatric	JJ
cord-320331-wtxja5i9	129	9	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	129	10	patients	patient	NNS
cord-320331-wtxja5i9	129	11	with	with	IN
cord-320331-wtxja5i9	129	12	diabetes	diabetes	NN
cord-320331-wtxja5i9	129	13	mellitus	mellitus	NN
cord-320331-wtxja5i9	129	14	(	(	-LRB-
cord-320331-wtxja5i9	129	15	DM	DM	NNP
cord-320331-wtxja5i9	129	16	)	)	-RRB-
cord-320331-wtxja5i9	129	17	in	in	IN
cord-320331-wtxja5i9	129	18	Daegun	Daegun	NNP
cord-320331-wtxja5i9	129	19	,	,	,
cord-320331-wtxja5i9	129	20	South	South	NNP
cord-320331-wtxja5i9	129	21	Korea	Korea	NNP
cord-320331-wtxja5i9	129	22	,	,	,
cord-320331-wtxja5i9	129	23	use	use	NN
cord-320331-wtxja5i9	129	24	of	of	IN
cord-320331-wtxja5i9	129	25	ACEi	ACEi	NNP
cord-320331-wtxja5i9	129	26	/	/	SYM
cord-320331-wtxja5i9	129	27	ARB	ARB	NNP
cord-320331-wtxja5i9	129	28	drugs	drug	NNS
cord-320331-wtxja5i9	129	29	did	do	VBD
cord-320331-wtxja5i9	129	30	not	not	RB
cord-320331-wtxja5i9	129	31	significantly	significantly	RB
cord-320331-wtxja5i9	129	32	affect	affect	VB
cord-320331-wtxja5i9	129	33	the	the	DT
cord-320331-wtxja5i9	129	34	severity	severity	NN
cord-320331-wtxja5i9	129	35	of	of	IN
cord-320331-wtxja5i9	129	36	outcome	outcome	NN
cord-320331-wtxja5i9	129	37	of	of	IN
cord-320331-wtxja5i9	129	38	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	129	39	,	,	,
cord-320331-wtxja5i9	129	40	apart	apart	RB
cord-320331-wtxja5i9	129	41	from	from	IN
cord-320331-wtxja5i9	129	42	an	an	DT
cord-320331-wtxja5i9	129	43	incidental	incidental	JJ
cord-320331-wtxja5i9	129	44	protective	protective	JJ
cord-320331-wtxja5i9	129	45	effect	effect	NN
cord-320331-wtxja5i9	129	46	against	against	IN
cord-320331-wtxja5i9	129	47	acute	acute	JJ
cord-320331-wtxja5i9	129	48	cardiac	cardiac	JJ
cord-320331-wtxja5i9	129	49	injury	injury	NN
cord-320331-wtxja5i9	129	50	(	(	-LRB-
cord-320331-wtxja5i9	129	51	OR	OR	NNP
cord-320331-wtxja5i9	129	52	0.048	0.048	LS
cord-320331-wtxja5i9	129	53	)	)	-RRB-
cord-320331-wtxja5i9	129	54	,	,	,
cord-320331-wtxja5i9	129	55	which	which	WDT
cord-320331-wtxja5i9	129	56	was	be	VBD
cord-320331-wtxja5i9	129	57	expected	expect	VBN
cord-320331-wtxja5i9	129	58	from	from	IN
cord-320331-wtxja5i9	129	59	the	the	DT
cord-320331-wtxja5i9	129	60	mechanism	mechanism	NN
cord-320331-wtxja5i9	129	61	of	of	IN
cord-320331-wtxja5i9	129	62	action	action	NN
cord-320331-wtxja5i9	129	63	of	of	IN
cord-320331-wtxja5i9	129	64	the	the	DT
cord-320331-wtxja5i9	129	65	drugs	drug	NNS
cord-320331-wtxja5i9	129	66	[	[	-LRB-
cord-320331-wtxja5i9	129	67	97	97	CD
cord-320331-wtxja5i9	129	68	]	]	-RRB-
cord-320331-wtxja5i9	129	69	.	.	.
cord-320331-wtxja5i9	130	1	Another	another	DT
cord-320331-wtxja5i9	130	2	review	review	NN
cord-320331-wtxja5i9	130	3	article	article	NN
cord-320331-wtxja5i9	130	4	discussing	discuss	VBG
cord-320331-wtxja5i9	130	5	the	the	DT
cord-320331-wtxja5i9	130	6	interaction	interaction	NN
cord-320331-wtxja5i9	130	7	between	between	IN
cord-320331-wtxja5i9	130	8	RAAS	RAAS	NNP
cord-320331-wtxja5i9	130	9	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	130	10	and	and	CC
cord-320331-wtxja5i9	130	11	ACE2	ACE2	NNP
cord-320331-wtxja5i9	130	12	in	in	IN
cord-320331-wtxja5i9	130	13	the	the	DT
cord-320331-wtxja5i9	130	14	context	context	NN
cord-320331-wtxja5i9	130	15	of	of	IN
cord-320331-wtxja5i9	130	16	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	130	17	claimed	claim	VBD
cord-320331-wtxja5i9	130	18	that	that	IN
cord-320331-wtxja5i9	130	19	although	although	IN
cord-320331-wtxja5i9	130	20	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	130	21	-	-	HYPH
cord-320331-wtxja5i9	130	22	receptor	receptor	NN
cord-320331-wtxja5i9	130	23	blockers	blocker	NNS
cord-320331-wtxja5i9	130	24	and	and	CC
cord-320331-wtxja5i9	130	25	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	130	26	blockers	blocker	NNS
cord-320331-wtxja5i9	130	27	increased	increase	VBD
cord-320331-wtxja5i9	130	28	ACE2	ACE2	NNP
cord-320331-wtxja5i9	130	29	expression	expression	NN
cord-320331-wtxja5i9	130	30	in	in	IN
cord-320331-wtxja5i9	130	31	a	a	DT
cord-320331-wtxja5i9	130	32	number	number	NN
cord-320331-wtxja5i9	130	33	of	of	IN
cord-320331-wtxja5i9	130	34	experimental	experimental	JJ
cord-320331-wtxja5i9	130	35	and	and	CC
cord-320331-wtxja5i9	130	36	clinical	clinical	JJ
cord-320331-wtxja5i9	130	37	models	model	NNS
cord-320331-wtxja5i9	130	38	,	,	,
cord-320331-wtxja5i9	130	39	ACE2	ACE2	NNP
cord-320331-wtxja5i9	130	40	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	130	41	,	,	,
cord-320331-wtxja5i9	130	42	while	while	IN
cord-320331-wtxja5i9	130	43	increasing	increase	VBG
cord-320331-wtxja5i9	130	44	cardiac	cardiac	JJ
cord-320331-wtxja5i9	130	45	ACE2	ACE2	NNP
cord-320331-wtxja5i9	130	46	mRNA	mRNA	NNP
cord-320331-wtxja5i9	130	47	levels	level	NNS
cord-320331-wtxja5i9	130	48	,	,	,
cord-320331-wtxja5i9	130	49	had	have	VBD
cord-320331-wtxja5i9	130	50	no	no	DT
cord-320331-wtxja5i9	130	51	effect	effect	NN
cord-320331-wtxja5i9	130	52	on	on	IN
cord-320331-wtxja5i9	130	53	ACE2	ACE2	NNP
cord-320331-wtxja5i9	130	54	activity	activity	NN
cord-320331-wtxja5i9	130	55	and	and	CC
cord-320331-wtxja5i9	130	56	expression	expression	NN
cord-320331-wtxja5i9	130	57	.	.	.
cord-320331-wtxja5i9	131	1	A	a	DT
cord-320331-wtxja5i9	131	2	direct	direct	JJ
cord-320331-wtxja5i9	131	3	inhibitor	inhibitor	NN
cord-320331-wtxja5i9	131	4	of	of	IN
cord-320331-wtxja5i9	131	5	renin	renin	NN
cord-320331-wtxja5i9	131	6	,	,	,
cord-320331-wtxja5i9	131	7	aliskiren	aliskiren	NNP
cord-320331-wtxja5i9	131	8	,	,	,
cord-320331-wtxja5i9	131	9	in	in	IN
cord-320331-wtxja5i9	131	10	contrast	contrast	NN
cord-320331-wtxja5i9	131	11	was	be	VBD
cord-320331-wtxja5i9	131	12	associated	associate	VBN
cord-320331-wtxja5i9	131	13	with	with	IN
cord-320331-wtxja5i9	131	14	a	a	DT
cord-320331-wtxja5i9	131	15	decrease	decrease	NN
cord-320331-wtxja5i9	131	16	in	in	IN
cord-320331-wtxja5i9	131	17	ACE2	ACE2	NNP
cord-320331-wtxja5i9	131	18	expression	expression	NN
cord-320331-wtxja5i9	131	19	but	but	CC
cord-320331-wtxja5i9	131	20	the	the	DT
cord-320331-wtxja5i9	131	21	mechanism	mechanism	NN
cord-320331-wtxja5i9	131	22	of	of	IN
cord-320331-wtxja5i9	131	23	action	action	NN
cord-320331-wtxja5i9	131	24	remains	remain	VBZ
cord-320331-wtxja5i9	131	25	to	to	TO
cord-320331-wtxja5i9	131	26	be	be	VB
cord-320331-wtxja5i9	131	27	studied	study	VBN
cord-320331-wtxja5i9	131	28	further	further	RB
cord-320331-wtxja5i9	131	29	[	[	-LRB-
cord-320331-wtxja5i9	131	30	98	98	CD
cord-320331-wtxja5i9	131	31	]	]	-RRB-
cord-320331-wtxja5i9	131	32	.	.	.
cord-320331-wtxja5i9	132	1	In	in	IN
cord-320331-wtxja5i9	132	2	contrast	contrast	NN
cord-320331-wtxja5i9	132	3	,	,	,
cord-320331-wtxja5i9	132	4	Wysocki	Wysocki	NNP
cord-320331-wtxja5i9	132	5	and	and	CC
cord-320331-wtxja5i9	132	6	authors	author	NNS
cord-320331-wtxja5i9	132	7	investigated	investigate	VBD
cord-320331-wtxja5i9	132	8	the	the	DT
cord-320331-wtxja5i9	132	9	effects	effect	NNS
cord-320331-wtxja5i9	132	10	of	of	IN
cord-320331-wtxja5i9	132	11	ACEis	aceis	NN
cord-320331-wtxja5i9	132	12	and	and	CC
cord-320331-wtxja5i9	132	13	ARBs	arb	NNS
cord-320331-wtxja5i9	132	14	on	on	IN
cord-320331-wtxja5i9	132	15	membrane	membrane	NN
cord-320331-wtxja5i9	132	16	and	and	CC
cord-320331-wtxja5i9	132	17	total	total	JJ
cord-320331-wtxja5i9	132	18	ACE2	ACE2	NNP
cord-320331-wtxja5i9	132	19	expression	expression	NN
cord-320331-wtxja5i9	132	20	in	in	IN
cord-320331-wtxja5i9	132	21	lung	lung	NN
cord-320331-wtxja5i9	132	22	and	and	CC
cord-320331-wtxja5i9	132	23	kidney	kidney	NN
cord-320331-wtxja5i9	132	24	cells	cell	NNS
cord-320331-wtxja5i9	132	25	and	and	CC
cord-320331-wtxja5i9	132	26	lysates	lysate	NNS
cord-320331-wtxja5i9	132	27	,	,	,
cord-320331-wtxja5i9	132	28	respectively	respectively	RB
cord-320331-wtxja5i9	132	29	,	,	,
cord-320331-wtxja5i9	132	30	and	and	CC
cord-320331-wtxja5i9	132	31	found	find	VBD
cord-320331-wtxja5i9	132	32	that	that	IN
cord-320331-wtxja5i9	132	33	use	use	NN
cord-320331-wtxja5i9	132	34	of	of	IN
cord-320331-wtxja5i9	132	35	these	these	DT
cord-320331-wtxja5i9	132	36	drugs	drug	NNS
cord-320331-wtxja5i9	132	37	do	do	VBP
cord-320331-wtxja5i9	132	38	not	not	RB
cord-320331-wtxja5i9	132	39	significantly	significantly	RB
cord-320331-wtxja5i9	132	40	affect	affect	VB
cord-320331-wtxja5i9	132	41	both	both	CC
cord-320331-wtxja5i9	132	42	the	the	DT
cord-320331-wtxja5i9	132	43	membrane	membrane	NN
cord-320331-wtxja5i9	132	44	and	and	CC
cord-320331-wtxja5i9	132	45	total	total	JJ
cord-320331-wtxja5i9	132	46	ACE2	ACE2	NNP
cord-320331-wtxja5i9	132	47	protein	protein	NN
cord-320331-wtxja5i9	132	48	levels	level	NNS
cord-320331-wtxja5i9	132	49	in	in	IN
cord-320331-wtxja5i9	132	50	mouse	mouse	NN
cord-320331-wtxja5i9	132	51	lungs	lung	NNS
cord-320331-wtxja5i9	132	52	.	.	.
cord-320331-wtxja5i9	133	1	Likewise	likewise	RB
cord-320331-wtxja5i9	133	2	,	,	,
cord-320331-wtxja5i9	133	3	ACEi	ACEi	NNP
cord-320331-wtxja5i9	133	4	(	(	-LRB-
cord-320331-wtxja5i9	133	5	captopril	captopril	NNP
cord-320331-wtxja5i9	133	6	)	)	-RRB-
cord-320331-wtxja5i9	133	7	and	and	CC
cord-320331-wtxja5i9	133	8	ARB	ARB	NNP
cord-320331-wtxja5i9	133	9	(	(	-LRB-
cord-320331-wtxja5i9	133	10	telmisartan	telmisartan	NNP
cord-320331-wtxja5i9	133	11	)	)	-RRB-
cord-320331-wtxja5i9	133	12	administration	administration	NN
cord-320331-wtxja5i9	133	13	did	do	VBD
cord-320331-wtxja5i9	133	14	not	not	RB
cord-320331-wtxja5i9	133	15	increase	increase	VB
cord-320331-wtxja5i9	133	16	membrane	membrane	NN
cord-320331-wtxja5i9	133	17	ACE2	ACE2	NNP
cord-320331-wtxja5i9	133	18	levels	level	NNS
cord-320331-wtxja5i9	133	19	in	in	IN
cord-320331-wtxja5i9	133	20	mouse	mouse	NN
cord-320331-wtxja5i9	133	21	idneys	idneys	NNP
cord-320331-wtxja5i9	133	22	,	,	,
cord-320331-wtxja5i9	133	23	but	but	CC
cord-320331-wtxja5i9	133	24	rather	rather	RB
cord-320331-wtxja5i9	133	25	decreased	decrease	VBD
cord-320331-wtxja5i9	133	26	them	-PRON-	PRP
cord-320331-wtxja5i9	133	27	.	.	.
cord-320331-wtxja5i9	134	1	Although	although	IN
cord-320331-wtxja5i9	134	2	preliminary	preliminary	JJ
cord-320331-wtxja5i9	134	3	,	,	,
cord-320331-wtxja5i9	134	4	this	this	DT
cord-320331-wtxja5i9	134	5	study	study	NN
cord-320331-wtxja5i9	134	6	provided	provide	VBD
cord-320331-wtxja5i9	134	7	direct	direct	JJ
cord-320331-wtxja5i9	134	8	evidence	evidence	NN
cord-320331-wtxja5i9	134	9	supporting	support	VBG
cord-320331-wtxja5i9	134	10	continued	continue	VBN
cord-320331-wtxja5i9	134	11	use	use	NN
cord-320331-wtxja5i9	134	12	of	of	IN
cord-320331-wtxja5i9	134	13	ACEis	aceis	NN
cord-320331-wtxja5i9	134	14	and	and	CC
cord-320331-wtxja5i9	134	15	ARBs	arb	NNS
cord-320331-wtxja5i9	134	16	in	in	IN
cord-320331-wtxja5i9	134	17	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	134	18	,	,	,
cord-320331-wtxja5i9	134	19	which	which	WDT
cord-320331-wtxja5i9	134	20	also	also	RB
cord-320331-wtxja5i9	134	21	implied	imply	VBD
cord-320331-wtxja5i9	134	22	that	that	IN
cord-320331-wtxja5i9	134	23	feedback	feedback	NN
cord-320331-wtxja5i9	134	24	upregulation	upregulation	NN
cord-320331-wtxja5i9	134	25	of	of	IN
cord-320331-wtxja5i9	134	26	ACE2	ACE2	NNP
cord-320331-wtxja5i9	134	27	does	do	VBZ
cord-320331-wtxja5i9	134	28	not	not	RB
cord-320331-wtxja5i9	134	29	occur	occur	VB
cord-320331-wtxja5i9	134	30	even	even	RB
cord-320331-wtxja5i9	134	31	if	if	IN
cord-320331-wtxja5i9	134	32	the	the	DT
cord-320331-wtxja5i9	134	33	RAS	RAS	NNP
cord-320331-wtxja5i9	134	34	pathway	pathway	NN
cord-320331-wtxja5i9	134	35	is	be	VBZ
cord-320331-wtxja5i9	134	36	inhibited	inhibit	VBN
cord-320331-wtxja5i9	134	37	,	,	,
cord-320331-wtxja5i9	134	38	at	at	IN
cord-320331-wtxja5i9	134	39	least	least	JJS
cord-320331-wtxja5i9	134	40	for	for	IN
cord-320331-wtxja5i9	134	41	a	a	DT
cord-320331-wtxja5i9	134	42	span	span	NN
cord-320331-wtxja5i9	134	43	of	of	IN
cord-320331-wtxja5i9	134	44	2	2	CD
cord-320331-wtxja5i9	134	45	weeks	week	NNS
cord-320331-wtxja5i9	134	46	[	[	-LRB-
cord-320331-wtxja5i9	134	47	99	99	CD
cord-320331-wtxja5i9	134	48	]	]	-RRB-
cord-320331-wtxja5i9	134	49	.	.	.
cord-320331-wtxja5i9	135	1	It	-PRON-	PRP
cord-320331-wtxja5i9	135	2	will	will	MD
cord-320331-wtxja5i9	135	3	also	also	RB
cord-320331-wtxja5i9	135	4	be	be	VB
cord-320331-wtxja5i9	135	5	interesting	interesting	JJ
cord-320331-wtxja5i9	135	6	to	to	IN
cord-320331-wtxja5i9	135	7	J	J	NNP
cord-320331-wtxja5i9	135	8	o	o	NN
cord-320331-wtxja5i9	135	9	u	u	NN
cord-320331-wtxja5i9	135	10	r	r	NN
cord-320331-wtxja5i9	135	11	n	n	NN
cord-320331-wtxja5i9	135	12	a	a	DT
cord-320331-wtxja5i9	135	13	l	l	NN
cord-320331-wtxja5i9	135	14	P	p	NN
cord-320331-wtxja5i9	135	15	r	r	NN
cord-320331-wtxja5i9	135	16	e	e	NN
cord-320331-wtxja5i9	135	17	-p	-p	NN
cord-320331-wtxja5i9	136	1	r	r	NN
cord-320331-wtxja5i9	136	2	o	o	NN
cord-320331-wtxja5i9	136	3	o	o	NN
cord-320331-wtxja5i9	136	4	f	f	NN
cord-320331-wtxja5i9	136	5	determine	determine	VB
cord-320331-wtxja5i9	136	6	similar	similar	JJ
cord-320331-wtxja5i9	136	7	responses	response	NNS
cord-320331-wtxja5i9	136	8	to	to	IN
cord-320331-wtxja5i9	136	9	ACEis	aceis	VB
cord-320331-wtxja5i9	136	10	and	and	CC
cord-320331-wtxja5i9	136	11	ARBs	arb	NNS
cord-320331-wtxja5i9	136	12	in	in	IN
cord-320331-wtxja5i9	136	13	mouse	mouse	NN
cord-320331-wtxja5i9	136	14	models	model	NNS
cord-320331-wtxja5i9	136	15	of	of	IN
cord-320331-wtxja5i9	136	16	hypertension	hypertension	NN
cord-320331-wtxja5i9	136	17	,	,	,
cord-320331-wtxja5i9	136	18	either	either	CC
cord-320331-wtxja5i9	136	19	genetic	genetic	JJ
cord-320331-wtxja5i9	136	20	or	or	CC
cord-320331-wtxja5i9	136	21	nongenetic	nongenetic	JJ
cord-320331-wtxja5i9	136	22	,	,	,
cord-320331-wtxja5i9	136	23	to	to	TO
cord-320331-wtxja5i9	136	24	determine	determine	VB
cord-320331-wtxja5i9	136	25	the	the	DT
cord-320331-wtxja5i9	136	26	consistency	consistency	NN
cord-320331-wtxja5i9	136	27	of	of	IN
cord-320331-wtxja5i9	136	28	these	these	DT
cord-320331-wtxja5i9	136	29	results	result	NNS
cord-320331-wtxja5i9	136	30	in	in	IN
cord-320331-wtxja5i9	136	31	the	the	DT
cord-320331-wtxja5i9	136	32	setting	setting	NN
cord-320331-wtxja5i9	136	33	of	of	IN
cord-320331-wtxja5i9	136	34	compensatory	compensatory	JJ
cord-320331-wtxja5i9	136	35	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	136	36	.	.	.
cord-320331-wtxja5i9	137	1	Besides	besides	IN
cord-320331-wtxja5i9	137	2	these	these	DT
cord-320331-wtxja5i9	137	3	studies	study	NNS
cord-320331-wtxja5i9	137	4	,	,	,
cord-320331-wtxja5i9	137	5	others	other	NNS
cord-320331-wtxja5i9	137	6	that	that	WDT
cord-320331-wtxja5i9	137	7	directly	directly	RB
cord-320331-wtxja5i9	137	8	assessed	assess	VBD
cord-320331-wtxja5i9	137	9	the	the	DT
cord-320331-wtxja5i9	137	10	clinical	clinical	JJ
cord-320331-wtxja5i9	137	11	effects	effect	NNS
cord-320331-wtxja5i9	137	12	of	of	IN
cord-320331-wtxja5i9	137	13	ACEi	ACEi	NNS
cord-320331-wtxja5i9	137	14	/	/	SYM
cord-320331-wtxja5i9	137	15	ARB	ARB	NNP
cord-320331-wtxja5i9	137	16	drugs	drug	NNS
cord-320331-wtxja5i9	137	17	on	on	IN
cord-320331-wtxja5i9	137	18	COVID-19	covid-19	DT
cord-320331-wtxja5i9	137	19	outcome	outcome	NN
cord-320331-wtxja5i9	137	20	severity	severity	NN
cord-320331-wtxja5i9	137	21	were	be	VBD
cord-320331-wtxja5i9	137	22	not	not	RB
cord-320331-wtxja5i9	137	23	found	find	VBN
cord-320331-wtxja5i9	137	24	during	during	IN
cord-320331-wtxja5i9	137	25	the	the	DT
cord-320331-wtxja5i9	137	26	literature	literature	NN
cord-320331-wtxja5i9	137	27	search	search	NN
cord-320331-wtxja5i9	137	28	.	.	.
cord-320331-wtxja5i9	138	1	Hence	hence	RB
cord-320331-wtxja5i9	138	2	,	,	,
cord-320331-wtxja5i9	138	3	the	the	DT
cord-320331-wtxja5i9	138	4	direct	direct	JJ
cord-320331-wtxja5i9	138	5	negative	negative	JJ
cord-320331-wtxja5i9	138	6	effects	effect	NNS
cord-320331-wtxja5i9	138	7	of	of	IN
cord-320331-wtxja5i9	138	8	ACEi	ACEi	NNS
cord-320331-wtxja5i9	138	9	/	/	SYM
cord-320331-wtxja5i9	138	10	ARB	ARB	NNP
cord-320331-wtxja5i9	138	11	drugs	drug	NNS
cord-320331-wtxja5i9	138	12	on	on	IN
cord-320331-wtxja5i9	138	13	COVID-19	covid-19	DT
cord-320331-wtxja5i9	138	14	outcome	outcome	NN
cord-320331-wtxja5i9	138	15	,	,	,
cord-320331-wtxja5i9	138	16	as	as	IN
cord-320331-wtxja5i9	138	17	earlier	early	RBR
cord-320331-wtxja5i9	138	18	hypothesized	hypothesize	VBN
cord-320331-wtxja5i9	138	19	by	by	IN
cord-320331-wtxja5i9	138	20	clinicians	clinician	NNS
cord-320331-wtxja5i9	138	21	and	and	CC
cord-320331-wtxja5i9	138	22	researchers	researcher	NNS
cord-320331-wtxja5i9	138	23	,	,	,
cord-320331-wtxja5i9	138	24	are	be	VBP
cord-320331-wtxja5i9	138	25	at	at	IN
cord-320331-wtxja5i9	138	26	best	good	JJS
cord-320331-wtxja5i9	138	27	experimental	experimental	JJ
cord-320331-wtxja5i9	138	28	and	and	CC
cord-320331-wtxja5i9	138	29	,	,	,
cord-320331-wtxja5i9	138	30	to	to	IN
cord-320331-wtxja5i9	138	31	the	the	DT
cord-320331-wtxja5i9	138	32	best	good	JJS
cord-320331-wtxja5i9	138	33	of	of	IN
cord-320331-wtxja5i9	138	34	our	-PRON-	PRP$
cord-320331-wtxja5i9	138	35	knowledge	knowledge	NN
cord-320331-wtxja5i9	138	36	,	,	,
cord-320331-wtxja5i9	138	37	not	not	RB
cord-320331-wtxja5i9	138	38	yet	yet	RB
cord-320331-wtxja5i9	138	39	supported	support	VBN
cord-320331-wtxja5i9	138	40	by	by	IN
cord-320331-wtxja5i9	138	41	clinical	clinical	JJ
cord-320331-wtxja5i9	138	42	evidence	evidence	NN
cord-320331-wtxja5i9	138	43	.	.	.
cord-320331-wtxja5i9	139	1	A	a	DT
cord-320331-wtxja5i9	139	2	more	more	RBR
cord-320331-wtxja5i9	139	3	in	in	IN
cord-320331-wtxja5i9	139	4	-	-	HYPH
cord-320331-wtxja5i9	139	5	depth	depth	NN
cord-320331-wtxja5i9	139	6	discussion	discussion	NN
cord-320331-wtxja5i9	139	7	on	on	IN
cord-320331-wtxja5i9	139	8	the	the	DT
cord-320331-wtxja5i9	139	9	interactions	interaction	NNS
cord-320331-wtxja5i9	139	10	between	between	IN
cord-320331-wtxja5i9	139	11	SARS	SARS	NNP
cord-320331-wtxja5i9	139	12	-	-	HYPH
cord-320331-wtxja5i9	139	13	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	139	14	entry	entry	NN
cord-320331-wtxja5i9	139	15	and	and	CC
cord-320331-wtxja5i9	139	16	ACEi	ACEi	NNP
cord-320331-wtxja5i9	139	17	/	/	SYM
cord-320331-wtxja5i9	139	18	ARB	ARB	NNP
cord-320331-wtxja5i9	139	19	drugs	drug	NNS
cord-320331-wtxja5i9	139	20	can	can	MD
cord-320331-wtxja5i9	139	21	be	be	VB
cord-320331-wtxja5i9	139	22	found	find	VBN
cord-320331-wtxja5i9	139	23	elsewhere	elsewhere	RB
cord-320331-wtxja5i9	139	24	,	,	,
cord-320331-wtxja5i9	139	25	and	and	CC
cord-320331-wtxja5i9	139	26	readers	reader	NNS
cord-320331-wtxja5i9	139	27	are	be	VBP
cord-320331-wtxja5i9	139	28	referred	refer	VBN
cord-320331-wtxja5i9	139	29	to	to	IN
cord-320331-wtxja5i9	139	30	those	those	DT
cord-320331-wtxja5i9	139	31	materials	material	NNS
cord-320331-wtxja5i9	139	32	for	for	IN
cord-320331-wtxja5i9	139	33	more	more	JJR
cord-320331-wtxja5i9	139	34	information	information	NN
cord-320331-wtxja5i9	139	35	.	.	.
cord-320331-wtxja5i9	140	1	The	the	DT
cord-320331-wtxja5i9	140	2	renin	renin	NN
cord-320331-wtxja5i9	140	3	-	-	HYPH
cord-320331-wtxja5i9	140	4	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	140	5	-	-	HYPH
cord-320331-wtxja5i9	140	6	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	140	7	system	system	NN
cord-320331-wtxja5i9	140	8	(	(	-LRB-
cord-320331-wtxja5i9	140	9	RAAS	RAAS	NNP
cord-320331-wtxja5i9	140	10	)	)	-RRB-
cord-320331-wtxja5i9	140	11	,	,	,
cord-320331-wtxja5i9	140	12	or	or	CC
cord-320331-wtxja5i9	140	13	simply	simply	RB
cord-320331-wtxja5i9	140	14	the	the	DT
cord-320331-wtxja5i9	140	15	renin	renin	NN
cord-320331-wtxja5i9	140	16	-	-	HYPH
cord-320331-wtxja5i9	140	17	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	140	18	system	system	NN
cord-320331-wtxja5i9	140	19	,	,	,
cord-320331-wtxja5i9	140	20	is	be	VBZ
cord-320331-wtxja5i9	140	21	a	a	DT
cord-320331-wtxja5i9	140	22	strong	strong	JJ
cord-320331-wtxja5i9	140	23	physiologic	physiologic	JJ
cord-320331-wtxja5i9	140	24	pathway	pathway	NN
cord-320331-wtxja5i9	140	25	that	that	WDT
cord-320331-wtxja5i9	140	26	controls	control	VBZ
cord-320331-wtxja5i9	140	27	various	various	JJ
cord-320331-wtxja5i9	140	28	processes	process	NNS
cord-320331-wtxja5i9	140	29	relating	relate	VBG
cord-320331-wtxja5i9	140	30	to	to	IN
cord-320331-wtxja5i9	140	31	salt	salt	NN
cord-320331-wtxja5i9	140	32	and	and	CC
cord-320331-wtxja5i9	140	33	water	water	NN
cord-320331-wtxja5i9	140	34	homeostasis	homeostasis	NN
cord-320331-wtxja5i9	140	35	(	(	-LRB-
cord-320331-wtxja5i9	140	36	Fig	Fig	NNP
cord-320331-wtxja5i9	140	37	1	1	CD
cord-320331-wtxja5i9	140	38	)	)	-RRB-
cord-320331-wtxja5i9	140	39	.	.	.
cord-320331-wtxja5i9	141	1	Classically	classically	RB
cord-320331-wtxja5i9	141	2	,	,	,
cord-320331-wtxja5i9	141	3	the	the	DT
cord-320331-wtxja5i9	141	4	chronological	chronological	JJ
cord-320331-wtxja5i9	141	5	order	order	NN
cord-320331-wtxja5i9	141	6	of	of	IN
cord-320331-wtxja5i9	141	7	the	the	DT
cord-320331-wtxja5i9	141	8	RAAS	RAAS	NNP
cord-320331-wtxja5i9	141	9	begins	begin	VBZ
cord-320331-wtxja5i9	141	10	with	with	IN
cord-320331-wtxja5i9	141	11	the	the	DT
cord-320331-wtxja5i9	141	12	cleavage	cleavage	NN
cord-320331-wtxja5i9	141	13	of	of	IN
cord-320331-wtxja5i9	141	14	angiotensinogen	angiotensinogen	NNP
cord-320331-wtxja5i9	141	15	into	into	IN
cord-320331-wtxja5i9	141	16	Ang	Ang	NNP
cord-320331-wtxja5i9	141	17	I	-PRON-	PRP
cord-320331-wtxja5i9	141	18	by	by	IN
cord-320331-wtxja5i9	141	19	renin	renin	NN
cord-320331-wtxja5i9	141	20	,	,	,
cord-320331-wtxja5i9	141	21	followed	follow	VBN
cord-320331-wtxja5i9	141	22	by	by	IN
cord-320331-wtxja5i9	141	23	the	the	DT
cord-320331-wtxja5i9	141	24	conversion	conversion	NN
cord-320331-wtxja5i9	141	25	of	of	IN
cord-320331-wtxja5i9	141	26	Ang	Ang	NNP
cord-320331-wtxja5i9	141	27	I	I	NNP
cord-320331-wtxja5i9	141	28	into	into	IN
cord-320331-wtxja5i9	141	29	Ang	Ang	NNP
cord-320331-wtxja5i9	141	30	II	II	NNP
cord-320331-wtxja5i9	141	31	by	by	IN
cord-320331-wtxja5i9	141	32	ACE	ACE	NNP
cord-320331-wtxja5i9	141	33	which	which	WDT
cord-320331-wtxja5i9	141	34	occurs	occur	VBZ
cord-320331-wtxja5i9	141	35	extensively	extensively	RB
cord-320331-wtxja5i9	141	36	in	in	IN
cord-320331-wtxja5i9	141	37	the	the	DT
cord-320331-wtxja5i9	141	38	lungs	lung	NNS
cord-320331-wtxja5i9	141	39	.	.	.
cord-320331-wtxja5i9	142	1	ACE2	ACE2	NNP
cord-320331-wtxja5i9	142	2	catalyzes	catalyze	VBZ
cord-320331-wtxja5i9	142	3	both	both	DT
cord-320331-wtxja5i9	143	1	Ang	Ang	NNP
cord-320331-wtxja5i9	143	2	I	I	NNP
cord-320331-wtxja5i9	143	3	and	and	CC
cord-320331-wtxja5i9	143	4	Ang	Ang	NNP
cord-320331-wtxja5i9	143	5	II	II	NNP
cord-320331-wtxja5i9	143	6	to	to	TO
cord-320331-wtxja5i9	143	7	produce	produce	VB
cord-320331-wtxja5i9	143	8	Ang	Ang	NNP
cord-320331-wtxja5i9	143	9	(	(	-LRB-
cord-320331-wtxja5i9	143	10	1	1	CD
cord-320331-wtxja5i9	143	11	-	-	SYM
cord-320331-wtxja5i9	143	12	9	9	CD
cord-320331-wtxja5i9	143	13	)	)	-RRB-
cord-320331-wtxja5i9	143	14	and	and	CC
cord-320331-wtxja5i9	143	15	Ang	Ang	NNP
cord-320331-wtxja5i9	143	16	(	(	-LRB-
cord-320331-wtxja5i9	143	17	1	1	CD
cord-320331-wtxja5i9	143	18	-	-	SYM
cord-320331-wtxja5i9	143	19	7	7	CD
cord-320331-wtxja5i9	143	20	)	)	-RRB-
cord-320331-wtxja5i9	143	21	,	,	,
cord-320331-wtxja5i9	143	22	which	which	WDT
cord-320331-wtxja5i9	143	23	provides	provide	VBZ
cord-320331-wtxja5i9	143	24	negative	negative	JJ
cord-320331-wtxja5i9	143	25	feedback	feedback	NN
cord-320331-wtxja5i9	143	26	to	to	IN
cord-320331-wtxja5i9	143	27	Ang	Ang	NNP
cord-320331-wtxja5i9	143	28	II	II	NNP
cord-320331-wtxja5i9	143	29	thereby	thereby	RB
cord-320331-wtxja5i9	143	30	modulating	modulate	VBG
cord-320331-wtxja5i9	143	31	its	-PRON-	PRP$
cord-320331-wtxja5i9	143	32	effects	effect	NNS
cord-320331-wtxja5i9	143	33	.	.	.
cord-320331-wtxja5i9	144	1	Prior	prior	RB
cord-320331-wtxja5i9	144	2	to	to	IN
cord-320331-wtxja5i9	144	3	ACE2	ACE2	NNP
cord-320331-wtxja5i9	144	4	interaction	interaction	NN
cord-320331-wtxja5i9	144	5	,	,	,
cord-320331-wtxja5i9	144	6	Ang	Ang	NNP
cord-320331-wtxja5i9	144	7	II	II	NNP
cord-320331-wtxja5i9	144	8	modulates	modulate	VBZ
cord-320331-wtxja5i9	144	9	the	the	DT
cord-320331-wtxja5i9	144	10	RAAS	RAAS	NNP
cord-320331-wtxja5i9	144	11	promotes	promote	VBZ
cord-320331-wtxja5i9	144	12	vasopressin	vasopressin	NN
cord-320331-wtxja5i9	144	13	release	release	NN
cord-320331-wtxja5i9	144	14	from	from	IN
cord-320331-wtxja5i9	144	15	the	the	DT
cord-320331-wtxja5i9	144	16	posterior	posterior	JJ
cord-320331-wtxja5i9	144	17	pituitary	pituitary	JJ
cord-320331-wtxja5i9	144	18	gland	gland	NN
cord-320331-wtxja5i9	144	19	,	,	,
cord-320331-wtxja5i9	144	20	and	and	CC
cord-320331-wtxja5i9	144	21	directs	direct	VBZ
cord-320331-wtxja5i9	144	22	the	the	DT
cord-320331-wtxja5i9	144	23	adrenal	adrenal	JJ
cord-320331-wtxja5i9	144	24	gland	gland	NN
cord-320331-wtxja5i9	144	25	to	to	TO
cord-320331-wtxja5i9	144	26	produce	produce	VB
cord-320331-wtxja5i9	144	27	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	144	28	,	,	,
cord-320331-wtxja5i9	144	29	which	which	WDT
cord-320331-wtxja5i9	144	30	then	then	RB
cord-320331-wtxja5i9	144	31	promotes	promote	VBZ
cord-320331-wtxja5i9	144	32	Na	Na	NNP
cord-320331-wtxja5i9	144	33	+	+	CC
cord-320331-wtxja5i9	144	34	and	and	CC
cord-320331-wtxja5i9	144	35	H	H	NNP
cord-320331-wtxja5i9	144	36	2	2	CD
cord-320331-wtxja5i9	144	37	O	o	NN
cord-320331-wtxja5i9	144	38	retention	retention	NN
cord-320331-wtxja5i9	144	39	in	in	IN
cord-320331-wtxja5i9	144	40	normal	normal	JJ
cord-320331-wtxja5i9	144	41	physiology	physiology	NN
cord-320331-wtxja5i9	144	42	.	.	.
cord-320331-wtxja5i9	145	1	In	in	IN
cord-320331-wtxja5i9	145	2	patients	patient	NNS
cord-320331-wtxja5i9	145	3	with	with	IN
cord-320331-wtxja5i9	145	4	cardiovascular	cardiovascular	JJ
cord-320331-wtxja5i9	145	5	disease	disease	NN
cord-320331-wtxja5i9	145	6	,	,	,
cord-320331-wtxja5i9	145	7	available	available	JJ
cord-320331-wtxja5i9	145	8	Ang	Ang	NNP
cord-320331-wtxja5i9	145	9	II	II	NNP
cord-320331-wtxja5i9	145	10	reacts	react	VBZ
cord-320331-wtxja5i9	145	11	with	with	IN
cord-320331-wtxja5i9	145	12	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	145	13	1	1	CD
cord-320331-wtxja5i9	145	14	receptor	receptor	NN
cord-320331-wtxja5i9	145	15	(	(	-LRB-
cord-320331-wtxja5i9	145	16	AT	at	IN
cord-320331-wtxja5i9	145	17	1	1	CD
cord-320331-wtxja5i9	145	18	R	r	NN
cord-320331-wtxja5i9	145	19	)	)	-RRB-
cord-320331-wtxja5i9	145	20	to	to	TO
cord-320331-wtxja5i9	145	21	stimulate	stimulate	VB
cord-320331-wtxja5i9	145	22	pathologic	pathologic	JJ
cord-320331-wtxja5i9	145	23	behavior	behavior	NN
cord-320331-wtxja5i9	145	24	such	such	JJ
cord-320331-wtxja5i9	145	25	as	as	IN
cord-320331-wtxja5i9	145	26	vasoconstriction	vasoconstriction	NN
cord-320331-wtxja5i9	145	27	,	,	,
cord-320331-wtxja5i9	145	28	oxidative	oxidative	JJ
cord-320331-wtxja5i9	145	29	stress	stress	NN
cord-320331-wtxja5i9	145	30	and	and	CC
cord-320331-wtxja5i9	145	31	profibrotic	profibrotic	JJ
cord-320331-wtxja5i9	145	32	events	event	NNS
cord-320331-wtxja5i9	145	33	.	.	.
cord-320331-wtxja5i9	146	1	Ang	Ang	NNP
cord-320331-wtxja5i9	146	2	II	II	NNP
cord-320331-wtxja5i9	146	3	is	be	VBZ
cord-320331-wtxja5i9	146	4	then	then	RB
cord-320331-wtxja5i9	146	5	converted	convert	VBN
cord-320331-wtxja5i9	146	6	into	into	IN
cord-320331-wtxja5i9	146	7	Ang	Ang	NNP
cord-320331-wtxja5i9	146	8	(	(	-LRB-
cord-320331-wtxja5i9	146	9	1	1	CD
cord-320331-wtxja5i9	146	10	-	-	SYM
cord-320331-wtxja5i9	146	11	7	7	CD
cord-320331-wtxja5i9	146	12	)	)	-RRB-
cord-320331-wtxja5i9	146	13	by	by	IN
cord-320331-wtxja5i9	146	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	146	15	,	,	,
cord-320331-wtxja5i9	146	16	followed	follow	VBN
cord-320331-wtxja5i9	146	17	by	by	IN
cord-320331-wtxja5i9	146	18	the	the	DT
cord-320331-wtxja5i9	146	19	activation	activation	NN
cord-320331-wtxja5i9	146	20	of	of	IN
cord-320331-wtxja5i9	146	21	AT	AT	NNP
cord-320331-wtxja5i9	146	22	2	2	CD
cord-320331-wtxja5i9	146	23	R	r	NN
cord-320331-wtxja5i9	146	24	and	and	CC
cord-320331-wtxja5i9	146	25	MasR.	MasR.	NNP
cord-320331-wtxja5i9	146	26	Elevation	Elevation	NNP
cord-320331-wtxja5i9	146	27	of	of	IN
cord-320331-wtxja5i9	146	28	Ang	Ang	NNP
cord-320331-wtxja5i9	146	29	II	II	NNP
cord-320331-wtxja5i9	146	30	may	may	MD
cord-320331-wtxja5i9	146	31	increase	increase	VB
cord-320331-wtxja5i9	146	32	plasma	plasma	NN
cord-320331-wtxja5i9	146	33	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	146	34	levels	level	NNS
cord-320331-wtxja5i9	146	35	through	through	IN
cord-320331-wtxja5i9	146	36	the	the	DT
cord-320331-wtxja5i9	146	37	regulatory	regulatory	JJ
cord-320331-wtxja5i9	146	38	action	action	NN
cord-320331-wtxja5i9	146	39	of	of	IN
cord-320331-wtxja5i9	146	40	adrenocorticotropic	adrenocorticotropic	NNP
cord-320331-wtxja5i9	146	41	hormone	hormone	NN
cord-320331-wtxja5i9	146	42	contrast	contrast	NN
cord-320331-wtxja5i9	146	43	,	,	,
cord-320331-wtxja5i9	146	44	Ang-(1	Ang-(1	NNP
cord-320331-wtxja5i9	146	45	-	-	HYPH
cord-320331-wtxja5i9	146	46	7	7	CD
cord-320331-wtxja5i9	146	47	)	)	-RRB-
cord-320331-wtxja5i9	146	48	increases	increase	VBZ
cord-320331-wtxja5i9	146	49	urinary	urinary	JJ
cord-320331-wtxja5i9	146	50	Na	Na	NNP
cord-320331-wtxja5i9	146	51	+	+	CC
cord-320331-wtxja5i9	146	52	excretion	excretion	NN
cord-320331-wtxja5i9	146	53	,	,	,
cord-320331-wtxja5i9	146	54	endothelial	endothelial	JJ
cord-320331-wtxja5i9	146	55	oxide	oxide	NN
cord-320331-wtxja5i9	146	56	activity	activity	NN
cord-320331-wtxja5i9	146	57	,	,	,
cord-320331-wtxja5i9	146	58	insulin	insulin	NN
cord-320331-wtxja5i9	146	59	sensitivity	sensitivity	NN
cord-320331-wtxja5i9	146	60	[	[	-LRB-
cord-320331-wtxja5i9	146	61	100	100	CD
cord-320331-wtxja5i9	146	62	]	]	-RRB-
cord-320331-wtxja5i9	146	63	.	.	.
cord-320331-wtxja5i9	147	1	This	this	DT
cord-320331-wtxja5i9	147	2	further	further	RB
cord-320331-wtxja5i9	147	3	shows	show	VBZ
cord-320331-wtxja5i9	147	4	that	that	IN
cord-320331-wtxja5i9	147	5	the	the	DT
cord-320331-wtxja5i9	147	6	ACE	ACE	NNP
cord-320331-wtxja5i9	147	7	2	2	CD
cord-320331-wtxja5i9	147	8	/	/	SYM
cord-320331-wtxja5i9	147	9	MasR	MasR	NNP
cord-320331-wtxja5i9	147	10	/	/	SYM
cord-320331-wtxja5i9	147	11	AT	at	IN
cord-320331-wtxja5i9	147	12	2	2	CD
cord-320331-wtxja5i9	147	13	R	r	NN
cord-320331-wtxja5i9	147	14	axis	axis	NN
cord-320331-wtxja5i9	147	15	performs	perform	VBZ
cord-320331-wtxja5i9	147	16	an	an	DT
cord-320331-wtxja5i9	147	17	opposite	opposite	JJ
cord-320331-wtxja5i9	147	18	reaction	reaction	NN
cord-320331-wtxja5i9	147	19	with	with	IN
cord-320331-wtxja5i9	147	20	the	the	DT
cord-320331-wtxja5i9	147	21	ACE	ACE	NNP
cord-320331-wtxja5i9	147	22	/	/	SYM
cord-320331-wtxja5i9	147	23	Ang	Ang	NNP
cord-320331-wtxja5i9	147	24	II	II	NNP
cord-320331-wtxja5i9	147	25	/	/	SYM
cord-320331-wtxja5i9	147	26	AT	at	IN
cord-320331-wtxja5i9	147	27	1	1	CD
cord-320331-wtxja5i9	147	28	R	r	NN
cord-320331-wtxja5i9	147	29	axis	axis	NN
cord-320331-wtxja5i9	147	30	,	,	,
cord-320331-wtxja5i9	147	31	offering	offer	VBG
cord-320331-wtxja5i9	147	32	protection	protection	NN
cord-320331-wtxja5i9	147	33	against	against	IN
cord-320331-wtxja5i9	147	34	hypertension	hypertension	NN
cord-320331-wtxja5i9	147	35	,	,	,
cord-320331-wtxja5i9	147	36	fibrosis	fibrosis	NN
cord-320331-wtxja5i9	147	37	,	,	,
cord-320331-wtxja5i9	147	38	and	and	CC
cord-320331-wtxja5i9	147	39	oxidative	oxidative	JJ
cord-320331-wtxja5i9	147	40	stress	stress	NN
cord-320331-wtxja5i9	147	41	[	[	-LRB-
cord-320331-wtxja5i9	147	42	65	65	CD
cord-320331-wtxja5i9	147	43	]	]	-RRB-
cord-320331-wtxja5i9	147	44	.	.	.
cord-320331-wtxja5i9	148	1	As	as	IN
cord-320331-wtxja5i9	148	2	mentioned	mention	VBN
cord-320331-wtxja5i9	148	3	above	above	RB
cord-320331-wtxja5i9	148	4	,	,	,
cord-320331-wtxja5i9	148	5	SARS	SARS	NNP
cord-320331-wtxja5i9	148	6	-	-	HYPH
cord-320331-wtxja5i9	148	7	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	148	8	exploits	exploit	VBZ
cord-320331-wtxja5i9	148	9	and	and	CC
cord-320331-wtxja5i9	148	10	depletes	deplete	VBZ
cord-320331-wtxja5i9	148	11	these	these	DT
cord-320331-wtxja5i9	148	12	ACE2	ACE2	NNP
cord-320331-wtxja5i9	148	13	receptors	receptor	NNS
cord-320331-wtxja5i9	148	14	to	to	TO
cord-320331-wtxja5i9	148	15	facilitate	facilitate	VB
cord-320331-wtxja5i9	148	16	viral	viral	JJ
cord-320331-wtxja5i9	148	17	host	host	NN
cord-320331-wtxja5i9	148	18	cell	cell	NN
cord-320331-wtxja5i9	148	19	entry	entry	NN
cord-320331-wtxja5i9	148	20	and	and	CC
cord-320331-wtxja5i9	148	21	increase	increase	VB
cord-320331-wtxja5i9	148	22	its	-PRON-	PRP$
cord-320331-wtxja5i9	148	23	pathogenicity	pathogenicity	NN
cord-320331-wtxja5i9	148	24	.	.	.
cord-320331-wtxja5i9	149	1	The	the	DT
cord-320331-wtxja5i9	149	2	RAAS	RAAS	NNP
cord-320331-wtxja5i9	149	3	is	be	VBZ
cord-320331-wtxja5i9	149	4	dysregulated	dysregulate	VBN
cord-320331-wtxja5i9	149	5	following	follow	VBG
cord-320331-wtxja5i9	149	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	149	7	depletion	depletion	NN
cord-320331-wtxja5i9	149	8	,	,	,
cord-320331-wtxja5i9	149	9	promoting	promote	VBG
cord-320331-wtxja5i9	149	10	effects	effect	NNS
cord-320331-wtxja5i9	149	11	downstream	downstream	RB
cord-320331-wtxja5i9	149	12	of	of	IN
cord-320331-wtxja5i9	149	13	Ang	Ang	NNP
cord-320331-wtxja5i9	149	14	II	II	NNP
cord-320331-wtxja5i9	149	15	and	and	CC
cord-320331-wtxja5i9	149	16	therefore	therefore	RB
cord-320331-wtxja5i9	149	17	increasing	increase	VBG
cord-320331-wtxja5i9	149	18	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	149	19	secretion	secretion	NN
cord-320331-wtxja5i9	149	20	.	.	.
cord-320331-wtxja5i9	150	1	Aldosterone	Aldosterone	NNP
cord-320331-wtxja5i9	150	2	acts	act	NNS
cord-320331-wtxja5i9	150	3	by	by	IN
cord-320331-wtxja5i9	150	4	inhibiting	inhibit	VBG
cord-320331-wtxja5i9	150	5	sodium	sodium	NN
cord-320331-wtxja5i9	150	6	excretion	excretion	NN
cord-320331-wtxja5i9	150	7	in	in	IN
cord-320331-wtxja5i9	150	8	the	the	DT
cord-320331-wtxja5i9	150	9	distal	distal	JJ
cord-320331-wtxja5i9	150	10	convoluted	convoluted	JJ
cord-320331-wtxja5i9	150	11	tubule	tubule	NN
cord-320331-wtxja5i9	150	12	and	and	CC
cord-320331-wtxja5i9	150	13	collecting	collect	VBG
cord-320331-wtxja5i9	150	14	ducts	duct	NNS
cord-320331-wtxja5i9	150	15	via	via	IN
cord-320331-wtxja5i9	150	16	the	the	DT
cord-320331-wtxja5i9	150	17	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	150	18	receptors	receptor	NNS
cord-320331-wtxja5i9	150	19	.	.	.
cord-320331-wtxja5i9	151	1	While	while	IN
cord-320331-wtxja5i9	151	2	Na	Na	NNP
cord-320331-wtxja5i9	151	3	+	+	CC
cord-320331-wtxja5i9	151	4	is	be	VBZ
cord-320331-wtxja5i9	151	5	reabsorbed	reabsorb	VBN
cord-320331-wtxja5i9	151	6	and	and	CC
cord-320331-wtxja5i9	151	7	H	h	NN
cord-320331-wtxja5i9	151	8	2	2	CD
cord-320331-wtxja5i9	151	9	O	o	NN
cord-320331-wtxja5i9	151	10	is	be	VBZ
cord-320331-wtxja5i9	151	11	retained	retain	VBN
cord-320331-wtxja5i9	151	12	,	,	,
cord-320331-wtxja5i9	151	13	potassium	potassium	NN
cord-320331-wtxja5i9	151	14	is	be	VBZ
cord-320331-wtxja5i9	151	15	consequently	consequently	RB
cord-320331-wtxja5i9	151	16	excreted	excrete	VBN
cord-320331-wtxja5i9	151	17	,	,	,
cord-320331-wtxja5i9	151	18	and	and	CC
cord-320331-wtxja5i9	151	19	an	an	DT
cord-320331-wtxja5i9	151	20	excess	excess	NN
cord-320331-wtxja5i9	151	21	can	can	MD
cord-320331-wtxja5i9	151	22	lead	lead	VB
cord-320331-wtxja5i9	151	23	to	to	IN
cord-320331-wtxja5i9	151	24	wastage	wastage	NN
cord-320331-wtxja5i9	151	25	and	and	CC
cord-320331-wtxja5i9	151	26	hypokalemia	hypokalemia	NN
cord-320331-wtxja5i9	151	27	.	.	.
cord-320331-wtxja5i9	152	1	This	this	DT
cord-320331-wtxja5i9	152	2	is	be	VBZ
cord-320331-wtxja5i9	152	3	consistent	consistent	JJ
cord-320331-wtxja5i9	152	4	with	with	IN
cord-320331-wtxja5i9	152	5	the	the	DT
cord-320331-wtxja5i9	152	6	findings	finding	NNS
cord-320331-wtxja5i9	152	7	of	of	IN
cord-320331-wtxja5i9	152	8	Chen	Chen	NNP
cord-320331-wtxja5i9	152	9	et	et	NNP
cord-320331-wtxja5i9	152	10	.	.	.
cord-320331-wtxja5i9	153	1	al	al	NNP
cord-320331-wtxja5i9	153	2	.	.	.
cord-320331-wtxja5i9	154	1	from	from	IN
cord-320331-wtxja5i9	154	2	a	a	DT
cord-320331-wtxja5i9	154	3	cohort	cohort	NN
cord-320331-wtxja5i9	154	4	study	study	NN
cord-320331-wtxja5i9	154	5	of	of	IN
cord-320331-wtxja5i9	154	6	175	175	CD
cord-320331-wtxja5i9	154	7	COVID-19-positive	covid-19-positive	JJ
cord-320331-wtxja5i9	154	8	patients	patient	NNS
cord-320331-wtxja5i9	154	9	,	,	,
cord-320331-wtxja5i9	154	10	wherein	wherein	WRB
cord-320331-wtxja5i9	154	11	they	-PRON-	PRP
cord-320331-wtxja5i9	154	12	classified	classify	VBD
cord-320331-wtxja5i9	154	13	patients	patient	NNS
cord-320331-wtxja5i9	154	14	as	as	IN
cord-320331-wtxja5i9	154	15	either	either	DT
cord-320331-wtxja5i9	154	16	being	be	VBG
cord-320331-wtxja5i9	154	17	severely	severely	RB
cord-320331-wtxja5i9	154	18	hypokalemic	hypokalemic	JJ
cord-320331-wtxja5i9	154	19	(	(	-LRB-
cord-320331-wtxja5i9	154	20	17.71	17.71	CD
cord-320331-wtxja5i9	154	21	%	%	NN
cord-320331-wtxja5i9	154	22	)	)	-RRB-
cord-320331-wtxja5i9	155	1	,	,	,
cord-320331-wtxja5i9	155	2	hypokalemic	hypokalemic	NNP
cord-320331-wtxja5i9	155	3	(	(	-LRB-
cord-320331-wtxja5i9	155	4	36.57	36.57	CD
cord-320331-wtxja5i9	155	5	%	%	NN
cord-320331-wtxja5i9	155	6	)	)	-RRB-
cord-320331-wtxja5i9	155	7	,	,	,
cord-320331-wtxja5i9	155	8	or	or	CC
cord-320331-wtxja5i9	155	9	normokalemic	normokalemic	NNP
cord-320331-wtxja5i9	155	10	(	(	-LRB-
cord-320331-wtxja5i9	155	11	45.71	45.71	CD
cord-320331-wtxja5i9	155	12	%	%	NN
cord-320331-wtxja5i9	155	13	)	)	-RRB-
cord-320331-wtxja5i9	155	14	.	.	.
cord-320331-wtxja5i9	156	1	They	-PRON-	PRP
cord-320331-wtxja5i9	156	2	found	find	VBD
cord-320331-wtxja5i9	156	3	that	that	IN
cord-320331-wtxja5i9	156	4	patients	patient	NNS
cord-320331-wtxja5i9	156	5	with	with	IN
cord-320331-wtxja5i9	156	6	higher	high	JJR
cord-320331-wtxja5i9	156	7	hypokalemia	hypokalemia	NN
cord-320331-wtxja5i9	156	8	also	also	RB
cord-320331-wtxja5i9	156	9	had	have	VBD
cord-320331-wtxja5i9	156	10	increased	increase	VBN
cord-320331-wtxja5i9	156	11	creatinine	creatinine	NN
cord-320331-wtxja5i9	156	12	kinase	kinase	NN
cord-320331-wtxja5i9	156	13	(	(	-LRB-
cord-320331-wtxja5i9	156	14	CK	CK	NNP
cord-320331-wtxja5i9	156	15	)	)	-RRB-
cord-320331-wtxja5i9	156	16	,	,	,
cord-320331-wtxja5i9	156	17	lactate	lactate	NN
cord-320331-wtxja5i9	156	18	dehydrogenase	dehydrogenase	NN
cord-320331-wtxja5i9	156	19	(	(	-LRB-
cord-320331-wtxja5i9	156	20	LD	LD	NNP
cord-320331-wtxja5i9	156	21	)	)	-RRB-
cord-320331-wtxja5i9	156	22	and	and	CC
cord-320331-wtxja5i9	156	23	C	C	NNP
cord-320331-wtxja5i9	156	24	-	-	HYPH
cord-320331-wtxja5i9	156	25	reactive	reactive	JJ
cord-320331-wtxja5i9	156	26	protein	protein	NN
cord-320331-wtxja5i9	156	27	(	(	-LRB-
cord-320331-wtxja5i9	156	28	CRP	CRP	NNP
cord-320331-wtxja5i9	156	29	)	)	-RRB-
cord-320331-wtxja5i9	156	30	levels	level	NNS
cord-320331-wtxja5i9	156	31	,	,	,
cord-320331-wtxja5i9	156	32	along	along	IN
cord-320331-wtxja5i9	156	33	with	with	IN
cord-320331-wtxja5i9	156	34	a	a	DT
cord-320331-wtxja5i9	156	35	higher	high	JJR
cord-320331-wtxja5i9	156	36	body	body	NN
cord-320331-wtxja5i9	156	37	temperature	temperature	NN
cord-320331-wtxja5i9	156	38	,	,	,
cord-320331-wtxja5i9	156	39	which	which	WDT
cord-320331-wtxja5i9	156	40	were	be	VBD
cord-320331-wtxja5i9	156	41	consistent	consistent	JJ
cord-320331-wtxja5i9	156	42	with	with	IN
cord-320331-wtxja5i9	156	43	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	156	44	and	and	CC
cord-320331-wtxja5i9	156	45	catabolic	catabolic	JJ
cord-320331-wtxja5i9	156	46	pathways	pathway	NNS
cord-320331-wtxja5i9	156	47	[	[	-LRB-
cord-320331-wtxja5i9	156	48	101	101	CD
cord-320331-wtxja5i9	156	49	]	]	-RRB-
cord-320331-wtxja5i9	156	50	.	.	.
cord-320331-wtxja5i9	157	1	Some	some	DT
cord-320331-wtxja5i9	157	2	suggest	suggest	VBP
cord-320331-wtxja5i9	157	3	that	that	IN
cord-320331-wtxja5i9	157	4	the	the	DT
cord-320331-wtxja5i9	157	5	observed	observed	JJ
cord-320331-wtxja5i9	157	6	hypokalemia	hypokalemia	NN
cord-320331-wtxja5i9	157	7	among	among	IN
cord-320331-wtxja5i9	157	8	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	157	9	patients	patient	NNS
cord-320331-wtxja5i9	157	10	is	be	VBZ
cord-320331-wtxja5i9	157	11	not	not	RB
cord-320331-wtxja5i9	157	12	isolated	isolate	VBN
cord-320331-wtxja5i9	157	13	but	but	CC
cord-320331-wtxja5i9	157	14	rather	rather	RB
cord-320331-wtxja5i9	157	15	is	be	VBZ
cord-320331-wtxja5i9	157	16	part	part	NN
cord-320331-wtxja5i9	157	17	of	of	IN
cord-320331-wtxja5i9	157	18	a	a	DT
cord-320331-wtxja5i9	157	19	general	general	JJ
cord-320331-wtxja5i9	157	20	electrolyte	electrolyte	JJ
cord-320331-wtxja5i9	157	21	imbalance	imbalance	NN
cord-320331-wtxja5i9	157	22	.	.	.
cord-320331-wtxja5i9	158	1	On	on	IN
cord-320331-wtxja5i9	158	2	the	the	DT
cord-320331-wtxja5i9	158	3	other	other	JJ
cord-320331-wtxja5i9	158	4	hand	hand	NN
cord-320331-wtxja5i9	158	5	,	,	,
cord-320331-wtxja5i9	158	6	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	158	7	in	in	IN
cord-320331-wtxja5i9	158	8	the	the	DT
cord-320331-wtxja5i9	158	9	setting	setting	NN
cord-320331-wtxja5i9	158	10	of	of	IN
cord-320331-wtxja5i9	158	11	a	a	DT
cord-320331-wtxja5i9	158	12	dysregulated	dysregulate	VBN
cord-320331-wtxja5i9	158	13	RAAS	raa	NNS
cord-320331-wtxja5i9	158	14	may	may	MD
cord-320331-wtxja5i9	158	15	or	or	CC
cord-320331-wtxja5i9	158	16	may	may	MD
cord-320331-wtxja5i9	158	17	not	not	RB
cord-320331-wtxja5i9	158	18	be	be	VB
cord-320331-wtxja5i9	158	19	the	the	DT
cord-320331-wtxja5i9	158	20	cause	cause	NN
cord-320331-wtxja5i9	158	21	of	of	IN
cord-320331-wtxja5i9	158	22	hypokalemia	hypokalemia	NN
cord-320331-wtxja5i9	158	23	in	in	IN
cord-320331-wtxja5i9	158	24	some	some	DT
cord-320331-wtxja5i9	158	25	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	158	26	cases	case	NNS
cord-320331-wtxja5i9	158	27	,	,	,
cord-320331-wtxja5i9	158	28	but	but	CC
cord-320331-wtxja5i9	158	29	rather	rather	RB
cord-320331-wtxja5i9	158	30	tubular	tubular	JJ
cord-320331-wtxja5i9	158	31	dysfunction	dysfunction	NN
cord-320331-wtxja5i9	158	32	,	,	,
cord-320331-wtxja5i9	158	33	such	such	JJ
cord-320331-wtxja5i9	158	34	as	as	IN
cord-320331-wtxja5i9	158	35	renal	renal	JJ
cord-320331-wtxja5i9	158	36	tubular	tubular	JJ
cord-320331-wtxja5i9	158	37	acidosis	acidosis	NN
cord-320331-wtxja5i9	158	38	.	.	.
cord-320331-wtxja5i9	159	1	However	however	RB
cord-320331-wtxja5i9	159	2	,	,	,
cord-320331-wtxja5i9	159	3	studies	study	NNS
cord-320331-wtxja5i9	159	4	on	on	IN
cord-320331-wtxja5i9	159	5	this	this	DT
cord-320331-wtxja5i9	159	6	aspect	aspect	NN
cord-320331-wtxja5i9	159	7	remain	remain	VBP
cord-320331-wtxja5i9	159	8	elusive	elusive	JJ
cord-320331-wtxja5i9	159	9	.	.	.
cord-320331-wtxja5i9	160	1	Nonetheless	nonetheless	RB
cord-320331-wtxja5i9	160	2	,	,	,
cord-320331-wtxja5i9	160	3	there	there	EX
cord-320331-wtxja5i9	160	4	is	be	VBZ
cord-320331-wtxja5i9	160	5	evidence	evidence	NN
cord-320331-wtxja5i9	160	6	that	that	IN
cord-320331-wtxja5i9	160	7	potassium	potassium	NN
cord-320331-wtxja5i9	160	8	levels	level	NNS
cord-320331-wtxja5i9	160	9	,	,	,
cord-320331-wtxja5i9	160	10	which	which	WDT
cord-320331-wtxja5i9	160	11	are	be	VBP
cord-320331-wtxja5i9	160	12	mainly	mainly	RB
cord-320331-wtxja5i9	160	13	regulated	regulate	VBN
cord-320331-wtxja5i9	160	14	by	by	IN
cord-320331-wtxja5i9	160	15	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	160	16	,	,	,
cord-320331-wtxja5i9	160	17	are	be	VBP
cord-320331-wtxja5i9	160	18	commonly	commonly	RB
cord-320331-wtxja5i9	160	19	deranged	deranged	JJ
cord-320331-wtxja5i9	160	20	in	in	IN
cord-320331-wtxja5i9	160	21	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	160	22	patients	patient	NNS
cord-320331-wtxja5i9	160	23	,	,	,
cord-320331-wtxja5i9	160	24	and	and	CC
cord-320331-wtxja5i9	160	25	this	this	DT
cord-320331-wtxja5i9	160	26	could	could	MD
cord-320331-wtxja5i9	160	27	be	be	VB
cord-320331-wtxja5i9	160	28	due	due	JJ
cord-320331-wtxja5i9	160	29	to	to	IN
cord-320331-wtxja5i9	160	30	interactions	interaction	NNS
cord-320331-wtxja5i9	160	31	with	with	IN
cord-320331-wtxja5i9	160	32	the	the	DT
cord-320331-wtxja5i9	160	33	RAAS	raa	NNS
cord-320331-wtxja5i9	160	34	.	.	.
cord-320331-wtxja5i9	161	1	In	in	IN
cord-320331-wtxja5i9	161	2	the	the	DT
cord-320331-wtxja5i9	161	3	same	same	JJ
cord-320331-wtxja5i9	161	4	correspondence	correspondence	NN
cord-320331-wtxja5i9	161	5	published	publish	VBN
cord-320331-wtxja5i9	161	6	at	at	IN
cord-320331-wtxja5i9	161	7	The	the	DT
cord-320331-wtxja5i9	161	8	Lancet	Lancet	NNP
cord-320331-wtxja5i9	161	9	recommending	recommend	VBG
cord-320331-wtxja5i9	161	10	the	the	DT
cord-320331-wtxja5i9	161	11	exercise	exercise	NN
cord-320331-wtxja5i9	161	12	of	of	IN
cord-320331-wtxja5i9	161	13	caution	caution	NN
cord-320331-wtxja5i9	161	14	for	for	IN
cord-320331-wtxja5i9	161	15	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	161	16	patients	patient	NNS
cord-320331-wtxja5i9	161	17	under	under	IN
cord-320331-wtxja5i9	161	18	ACEi	ACEi	NNS
cord-320331-wtxja5i9	161	19	and	and	CC
cord-320331-wtxja5i9	161	20	ARB	ARB	NNP
cord-320331-wtxja5i9	161	21	drugs	drug	NNS
cord-320331-wtxja5i9	161	22	,	,	,
cord-320331-wtxja5i9	161	23	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	161	24	and	and	CC
cord-320331-wtxja5i9	161	25	thiazolidinediones	thiazolidinediones	NNPS
cord-320331-wtxja5i9	161	26	were	be	VBD
cord-320331-wtxja5i9	161	27	mentioned	mention	VBN
cord-320331-wtxja5i9	161	28	to	to	TO
cord-320331-wtxja5i9	161	29	potentially	potentially	RB
cord-320331-wtxja5i9	161	30	increase	increase	VB
cord-320331-wtxja5i9	161	31	ACE2	ACE2	NNP
cord-320331-wtxja5i9	161	32	expression	expression	NN
cord-320331-wtxja5i9	161	33	[	[	-LRB-
cord-320331-wtxja5i9	161	34	20	20	CD
cord-320331-wtxja5i9	161	35	]	]	-RRB-
cord-320331-wtxja5i9	161	36	.	.	.
cord-320331-wtxja5i9	162	1	Ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	162	2	is	be	VBZ
cord-320331-wtxja5i9	162	3	under	under	IN
cord-320331-wtxja5i9	162	4	the	the	DT
cord-320331-wtxja5i9	162	5	class	class	NN
cord-320331-wtxja5i9	162	6	known	know	VBN
cord-320331-wtxja5i9	162	7	as	as	IN
cord-320331-wtxja5i9	162	8	non	non	JJ
cord-320331-wtxja5i9	162	9	-	-	JJ
cord-320331-wtxja5i9	162	10	steroidal	steroidal	JJ
cord-320331-wtxja5i9	162	11	anti	anti	JJ
cord-320331-wtxja5i9	162	12	-	-	JJ
cord-320331-wtxja5i9	162	13	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	162	14	drugs	drug	NNS
cord-320331-wtxja5i9	162	15	(	(	-LRB-
cord-320331-wtxja5i9	162	16	NSAIDs	NSAIDs	NNP
cord-320331-wtxja5i9	162	17	)	)	-RRB-
cord-320331-wtxja5i9	162	18	,	,	,
cord-320331-wtxja5i9	162	19	and	and	CC
cord-320331-wtxja5i9	162	20	acts	act	NNS
cord-320331-wtxja5i9	162	21	by	by	IN
cord-320331-wtxja5i9	162	22	non	non	JJ
cord-320331-wtxja5i9	162	23	-	-	JJ
cord-320331-wtxja5i9	162	24	selectively	selectively	RB
cord-320331-wtxja5i9	162	25	inhibiting	inhibit	VBG
cord-320331-wtxja5i9	162	26	cyclooxygenase	cyclooxygenase	NN
cord-320331-wtxja5i9	162	27	enzymes	enzyme	NNS
cord-320331-wtxja5i9	162	28	(	(	-LRB-
cord-320331-wtxja5i9	162	29	COX	COX	NNP
cord-320331-wtxja5i9	162	30	)	)	-RRB-
cord-320331-wtxja5i9	162	31	1	1	CD
cord-320331-wtxja5i9	162	32	and	and	CC
cord-320331-wtxja5i9	162	33	2	2	CD
cord-320331-wtxja5i9	162	34	,	,	,
cord-320331-wtxja5i9	162	35	which	which	WDT
cord-320331-wtxja5i9	162	36	confers	confer	VBZ
cord-320331-wtxja5i9	162	37	its	-PRON-	PRP$
cord-320331-wtxja5i9	162	38	anti	anti	JJ
cord-320331-wtxja5i9	162	39	-	-	JJ
cord-320331-wtxja5i9	162	40	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	162	41	and	and	CC
cord-320331-wtxja5i9	162	42	antipyretic	antipyretic	JJ
cord-320331-wtxja5i9	162	43	effects	effect	NNS
cord-320331-wtxja5i9	162	44	through	through	IN
cord-320331-wtxja5i9	162	45	the	the	DT
cord-320331-wtxja5i9	162	46	inhibition	inhibition	NN
cord-320331-wtxja5i9	162	47	of	of	IN
cord-320331-wtxja5i9	162	48	prostaglandin	prostaglandin	JJ
cord-320331-wtxja5i9	162	49	synthesis	synthesis	NN
cord-320331-wtxja5i9	162	50	from	from	IN
cord-320331-wtxja5i9	162	51	arachidonic	arachidonic	JJ
cord-320331-wtxja5i9	162	52	acid	acid	NN
cord-320331-wtxja5i9	162	53	[	[	-LRB-
cord-320331-wtxja5i9	162	54	34	34	CD
cord-320331-wtxja5i9	162	55	,	,	,
cord-320331-wtxja5i9	162	56	35	35	CD
cord-320331-wtxja5i9	162	57	]	]	-RRB-
cord-320331-wtxja5i9	162	58	.	.	.
cord-320331-wtxja5i9	163	1	Of	of	IN
cord-320331-wtxja5i9	163	2	the	the	DT
cord-320331-wtxja5i9	163	3	four	four	CD
cord-320331-wtxja5i9	163	4	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	163	5	synthesized	synthesize	VBN
cord-320331-wtxja5i9	163	6	by	by	IN
cord-320331-wtxja5i9	163	7	this	this	DT
cord-320331-wtxja5i9	163	8	pathway	pathway	NN
cord-320331-wtxja5i9	163	9	,	,	,
cord-320331-wtxja5i9	163	10	PGE	PGE	NNP
cord-320331-wtxja5i9	163	11	2	2	CD
cord-320331-wtxja5i9	163	12	and	and	CC
cord-320331-wtxja5i9	163	13	PGI	PGI	NNP
cord-320331-wtxja5i9	163	14	2	2	CD
cord-320331-wtxja5i9	163	15	,	,	,
cord-320331-wtxja5i9	163	16	along	along	IN
cord-320331-wtxja5i9	163	17	with	with	IN
cord-320331-wtxja5i9	163	18	the	the	DT
cord-320331-wtxja5i9	163	19	prostanoid	prostanoid	NNP
cord-320331-wtxja5i9	163	20	thromboxane	thromboxane	NN
cord-320331-wtxja5i9	163	21	TXA	TXA	NNP
cord-320331-wtxja5i9	163	22	2	2	CD
cord-320331-wtxja5i9	163	23	,	,	,
cord-320331-wtxja5i9	163	24	are	be	VBP
cord-320331-wtxja5i9	163	25	produced	produce	VBN
cord-320331-wtxja5i9	163	26	specifically	specifically	RB
cord-320331-wtxja5i9	163	27	in	in	IN
cord-320331-wtxja5i9	163	28	the	the	DT
cord-320331-wtxja5i9	163	29	kidneys	kidney	NNS
cord-320331-wtxja5i9	163	30	,	,	,
cord-320331-wtxja5i9	163	31	while	while	IN
cord-320331-wtxja5i9	163	32	PGD	PGD	NNP
cord-320331-wtxja5i9	163	33	2	2	CD
cord-320331-wtxja5i9	163	34	is	be	VBZ
cord-320331-wtxja5i9	163	35	produced	produce	VBN
cord-320331-wtxja5i9	163	36	in	in	IN
cord-320331-wtxja5i9	163	37	the	the	DT
cord-320331-wtxja5i9	163	38	airways	airway	NNS
cord-320331-wtxja5i9	163	39	,	,	,
cord-320331-wtxja5i9	163	40	and	and	CC
cord-320331-wtxja5i9	163	41	they	-PRON-	PRP
cord-320331-wtxja5i9	163	42	act	act	VBP
cord-320331-wtxja5i9	163	43	by	by	IN
cord-320331-wtxja5i9	163	44	interacting	interact	VBG
cord-320331-wtxja5i9	163	45	with	with	IN
cord-320331-wtxja5i9	163	46	rhodopsin	rhodopsin	NN
cord-320331-wtxja5i9	163	47	-	-	HYPH
cord-320331-wtxja5i9	163	48	like	like	JJ
cord-320331-wtxja5i9	163	49	G	g	NN
cord-320331-wtxja5i9	163	50	-	-	HYPH
cord-320331-wtxja5i9	163	51	protein	protein	NN
cord-320331-wtxja5i9	163	52	coupled	coupled	JJ
cord-320331-wtxja5i9	163	53	receptors	receptor	NNS
cord-320331-wtxja5i9	163	54	or	or	CC
cord-320331-wtxja5i9	163	55	GPCRs	gpcr	NNS
cord-320331-wtxja5i9	163	56	[	[	-LRB-
cord-320331-wtxja5i9	163	57	35	35	CD
cord-320331-wtxja5i9	163	58	]	]	-RRB-
cord-320331-wtxja5i9	163	59	.	.	.
cord-320331-wtxja5i9	164	1	Interestingly	interestingly	RB
cord-320331-wtxja5i9	164	2	,	,	,
cord-320331-wtxja5i9	164	3	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	164	4	,	,	,
cord-320331-wtxja5i9	164	5	particularly	particularly	RB
cord-320331-wtxja5i9	164	6	PGE	PGE	NNP
cord-320331-wtxja5i9	164	7	2	2	CD
cord-320331-wtxja5i9	164	8	and	and	CC
cord-320331-wtxja5i9	164	9	PGI	PGI	NNP
cord-320331-wtxja5i9	164	10	2	2	CD
cord-320331-wtxja5i9	164	11	,	,	,
cord-320331-wtxja5i9	164	12	have	have	VBP
cord-320331-wtxja5i9	164	13	been	be	VBN
cord-320331-wtxja5i9	164	14	well	well	RB
cord-320331-wtxja5i9	164	15	-	-	HYPH
cord-320331-wtxja5i9	164	16	studied	study	VBN
cord-320331-wtxja5i9	164	17	and	and	CC
cord-320331-wtxja5i9	164	18	have	have	VBP
cord-320331-wtxja5i9	164	19	been	be	VBN
cord-320331-wtxja5i9	164	20	shown	show	VBN
cord-320331-wtxja5i9	164	21	to	to	TO
cord-320331-wtxja5i9	164	22	affect	affect	VB
cord-320331-wtxja5i9	164	23	kidneys	kidney	NNS
cord-320331-wtxja5i9	164	24	by	by	IN
cord-320331-wtxja5i9	164	25	improving	improve	VBG
cord-320331-wtxja5i9	164	26	blood	blood	NN
cord-320331-wtxja5i9	164	27	flow	flow	NN
cord-320331-wtxja5i9	164	28	through	through	IN
cord-320331-wtxja5i9	164	29	vasodilation	vasodilation	NN
cord-320331-wtxja5i9	164	30	.	.	.
cord-320331-wtxja5i9	165	1	Under	under	IN
cord-320331-wtxja5i9	165	2	conditions	condition	NNS
cord-320331-wtxja5i9	165	3	of	of	IN
cord-320331-wtxja5i9	165	4	reduced	reduce	VBN
cord-320331-wtxja5i9	165	5	renal	renal	JJ
cord-320331-wtxja5i9	165	6	flow	flow	NN
cord-320331-wtxja5i9	165	7	,	,	,
cord-320331-wtxja5i9	165	8	this	this	DT
cord-320331-wtxja5i9	165	9	mechanism	mechanism	NN
cord-320331-wtxja5i9	165	10	leads	lead	VBZ
cord-320331-wtxja5i9	165	11	to	to	IN
cord-320331-wtxja5i9	165	12	increased	increase	VBN
cord-320331-wtxja5i9	165	13	tubular	tubular	JJ
cord-320331-wtxja5i9	165	14	flow	flow	NN
cord-320331-wtxja5i9	165	15	,	,	,
cord-320331-wtxja5i9	165	16	increased	increase	VBN
cord-320331-wtxja5i9	165	17	renal	renal	JJ
cord-320331-wtxja5i9	165	18	perfusion	perfusion	NN
cord-320331-wtxja5i9	165	19	,	,	,
cord-320331-wtxja5i9	165	20	and	and	CC
cord-320331-wtxja5i9	165	21	increased	increase	VBD
cord-320331-wtxja5i9	165	22	glomerular	glomerular	JJ
cord-320331-wtxja5i9	165	23	filtration	filtration	NN
cord-320331-wtxja5i9	165	24	rate	rate	NN
cord-320331-wtxja5i9	165	25	,	,	,
cord-320331-wtxja5i9	165	26	with	with	IN
cord-320331-wtxja5i9	165	27	a	a	DT
cord-320331-wtxja5i9	165	28	concomitant	concomitant	JJ
cord-320331-wtxja5i9	165	29	increase	increase	NN
cord-320331-wtxja5i9	165	30	in	in	IN
cord-320331-wtxja5i9	165	31	the	the	DT
cord-320331-wtxja5i9	165	32	secretion	secretion	NN
cord-320331-wtxja5i9	165	33	of	of	IN
cord-320331-wtxja5i9	165	34	potassium	potassium	NN
cord-320331-wtxja5i9	165	35	(	(	-LRB-
cord-320331-wtxja5i9	165	36	Fig	Fig	NNP
cord-320331-wtxja5i9	165	37	.	.	.
cord-320331-wtxja5i9	165	38	1	1	CD
cord-320331-wtxja5i9	165	39	  	  	_SP
cord-320331-wtxja5i9	165	40	and	and	CC
cord-320331-wtxja5i9	165	41	2	2	CD
cord-320331-wtxja5i9	165	42	)	)	-RRB-
cord-320331-wtxja5i9	165	43	.	.	.
cord-320331-wtxja5i9	166	1	This	this	DT
cord-320331-wtxja5i9	166	2	is	be	VBZ
cord-320331-wtxja5i9	166	3	supported	support	VBN
cord-320331-wtxja5i9	166	4	by	by	IN
cord-320331-wtxja5i9	166	5	the	the	DT
cord-320331-wtxja5i9	166	6	fact	fact	NN
cord-320331-wtxja5i9	166	7	that	that	IN
cord-320331-wtxja5i9	166	8	PGE	PGE	NNP
cord-320331-wtxja5i9	166	9	2	2	CD
cord-320331-wtxja5i9	166	10	regulates	regulate	VBZ
cord-320331-wtxja5i9	166	11	sodium	sodium	NN
cord-320331-wtxja5i9	166	12	and	and	CC
cord-320331-wtxja5i9	166	13	water	water	NN
cord-320331-wtxja5i9	166	14	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	166	15	,	,	,
cord-320331-wtxja5i9	166	16	while	while	IN
cord-320331-wtxja5i9	166	17	PGI	PGI	NNP
cord-320331-wtxja5i9	166	18	2	2	CD
cord-320331-wtxja5i9	166	19	increases	increase	VBZ
cord-320331-wtxja5i9	166	20	the	the	DT
cord-320331-wtxja5i9	166	21	production	production	NN
cord-320331-wtxja5i9	166	22	of	of	IN
cord-320331-wtxja5i9	166	23	renin	renin	NN
cord-320331-wtxja5i9	166	24	--with	--with	NN
cord-320331-wtxja5i9	166	25	the	the	DT
cord-320331-wtxja5i9	166	26	latter	latter	JJ
cord-320331-wtxja5i9	166	27	increasing	increase	VBG
cord-320331-wtxja5i9	166	28	salt	salt	NN
cord-320331-wtxja5i9	166	29	and	and	CC
cord-320331-wtxja5i9	166	30	water	water	NN
cord-320331-wtxja5i9	166	31	retention	retention	NN
cord-320331-wtxja5i9	166	32	and	and	CC
cord-320331-wtxja5i9	166	33	hence	hence	RB
cord-320331-wtxja5i9	166	34	blood	blood	NN
cord-320331-wtxja5i9	166	35	volume	volume	NN
cord-320331-wtxja5i9	166	36	,	,	,
cord-320331-wtxja5i9	166	37	while	while	IN
cord-320331-wtxja5i9	166	38	PGE	PGE	NNP
cord-320331-wtxja5i9	166	39	2	2	CD
cord-320331-wtxja5i9	166	40	counteracts	counteract	VBZ
cord-320331-wtxja5i9	166	41	this	this	DT
cord-320331-wtxja5i9	166	42	process	process	NN
cord-320331-wtxja5i9	166	43	via	via	IN
cord-320331-wtxja5i9	166	44	volume	volume	NN
cord-320331-wtxja5i9	166	45	/	/	SYM
cord-320331-wtxja5i9	166	46	pressure	pressure	NN
cord-320331-wtxja5i9	166	47	natriuresis	natriuresis	NNP
cord-320331-wtxja5i9	166	48	[	[	-LRB-
cord-320331-wtxja5i9	166	49	36	36	CD
cord-320331-wtxja5i9	166	50	]	]	-RRB-
cord-320331-wtxja5i9	166	51	.	.	.
cord-320331-wtxja5i9	167	1	Since	since	IN
cord-320331-wtxja5i9	167	2	PGE	PGE	NNP
cord-320331-wtxja5i9	167	3	2	2	CD
cord-320331-wtxja5i9	167	4	is	be	VBZ
cord-320331-wtxja5i9	167	5	the	the	DT
cord-320331-wtxja5i9	167	6	main	main	JJ
cord-320331-wtxja5i9	167	7	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	167	8	in	in	IN
cord-320331-wtxja5i9	167	9	the	the	DT
cord-320331-wtxja5i9	167	10	kidney	kidney	NN
cord-320331-wtxja5i9	167	11	,	,	,
cord-320331-wtxja5i9	167	12	COX	COX	NNP
cord-320331-wtxja5i9	167	13	inhibition	inhibition	NN
cord-320331-wtxja5i9	167	14	leads	lead	VBZ
cord-320331-wtxja5i9	167	15	to	to	IN
cord-320331-wtxja5i9	167	16	an	an	DT
cord-320331-wtxja5i9	167	17	overall	overall	JJ
cord-320331-wtxja5i9	167	18	increase	increase	NN
cord-320331-wtxja5i9	167	19	in	in	IN
cord-320331-wtxja5i9	167	20	sodium	sodium	NN
cord-320331-wtxja5i9	167	21	and	and	CC
cord-320331-wtxja5i9	167	22	water	water	NN
cord-320331-wtxja5i9	167	23	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	167	24	.	.	.
cord-320331-wtxja5i9	168	1	Because	because	IN
cord-320331-wtxja5i9	168	2	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	168	3	and	and	CC
cord-320331-wtxja5i9	168	4	other	other	JJ
cord-320331-wtxja5i9	168	5	NSAIDs	nsaids	JJ
cord-320331-wtxja5i9	168	6	decrease	decrease	VBP
cord-320331-wtxja5i9	168	7	renal	renal	JJ
cord-320331-wtxja5i9	168	8	perfusion	perfusion	NN
cord-320331-wtxja5i9	168	9	by	by	IN
cord-320331-wtxja5i9	168	10	increasing	increase	VBG
cord-320331-wtxja5i9	168	11	systemic	systemic	JJ
cord-320331-wtxja5i9	168	12	vascular	vascular	JJ
cord-320331-wtxja5i9	168	13	resistance	resistance	NN
cord-320331-wtxja5i9	168	14	,	,	,
cord-320331-wtxja5i9	168	15	a	a	DT
cord-320331-wtxja5i9	168	16	vicious	vicious	JJ
cord-320331-wtxja5i9	168	17	cycle	cycle	NN
cord-320331-wtxja5i9	168	18	can	can	MD
cord-320331-wtxja5i9	168	19	be	be	VB
cord-320331-wtxja5i9	168	20	formed	form	VBN
cord-320331-wtxja5i9	168	21	by	by	IN
cord-320331-wtxja5i9	168	22	tricking	trick	VBG
cord-320331-wtxja5i9	168	23	the	the	DT
cord-320331-wtxja5i9	168	24	body	body	NN
cord-320331-wtxja5i9	168	25	to	to	TO
cord-320331-wtxja5i9	168	26	sense	sense	VB
cord-320331-wtxja5i9	168	27	that	that	IN
cord-320331-wtxja5i9	168	28	there	there	EX
cord-320331-wtxja5i9	168	29	is	be	VBZ
cord-320331-wtxja5i9	168	30	reduced	reduce	VBN
cord-320331-wtxja5i9	168	31	renal	renal	JJ
cord-320331-wtxja5i9	168	32	perfusion	perfusion	NN
cord-320331-wtxja5i9	168	33	,	,	,
cord-320331-wtxja5i9	168	34	leading	lead	VBG
cord-320331-wtxja5i9	168	35	to	to	IN
cord-320331-wtxja5i9	168	36	an	an	DT
cord-320331-wtxja5i9	168	37	inappropriate	inappropriate	JJ
cord-320331-wtxja5i9	168	38	upregulation	upregulation	NN
cord-320331-wtxja5i9	168	39	of	of	IN
cord-320331-wtxja5i9	168	40	ACE	ace	NN
cord-320331-wtxja5i9	168	41	to	to	TO
cord-320331-wtxja5i9	168	42	return	return	VB
cord-320331-wtxja5i9	168	43	kidney	kidney	NN
cord-320331-wtxja5i9	168	44	perfusion	perfusion	NN
cord-320331-wtxja5i9	168	45	back	back	RB
cord-320331-wtxja5i9	168	46	to	to	IN
cord-320331-wtxja5i9	168	47	normal	normal	JJ
cord-320331-wtxja5i9	168	48	via	via	IN
cord-320331-wtxja5i9	168	49	Ang	Ang	NNP
cord-320331-wtxja5i9	168	50	II	II	NNP
cord-320331-wtxja5i9	169	1	(	(	-LRB-
cord-320331-wtxja5i9	169	2	Fig	Fig	NNP
cord-320331-wtxja5i9	169	3	.	.	NNP
cord-320331-wtxja5i9	169	4	2	2	CD
cord-320331-wtxja5i9	169	5	)	)	-RRB-
cord-320331-wtxja5i9	169	6	.	.	.
cord-320331-wtxja5i9	170	1	Concomitantly	concomitantly	RB
cord-320331-wtxja5i9	170	2	,	,	,
cord-320331-wtxja5i9	170	3	an	an	DT
cord-320331-wtxja5i9	170	4	upregulation	upregulation	NN
cord-320331-wtxja5i9	170	5	of	of	IN
cord-320331-wtxja5i9	170	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	170	7	is	be	VBZ
cord-320331-wtxja5i9	170	8	expected	expect	VBN
cord-320331-wtxja5i9	170	9	by	by	IN
cord-320331-wtxja5i9	170	10	virtue	virtue	NN
cord-320331-wtxja5i9	170	11	of	of	IN
cord-320331-wtxja5i9	170	12	its	-PRON-	PRP$
cord-320331-wtxja5i9	170	13	role	role	NN
cord-320331-wtxja5i9	170	14	as	as	IN
cord-320331-wtxja5i9	170	15	a	a	DT
cord-320331-wtxja5i9	170	16	physiologic	physiologic	JJ
cord-320331-wtxja5i9	170	17	antagonist	antagonist	NN
cord-320331-wtxja5i9	170	18	of	of	IN
cord-320331-wtxja5i9	170	19	Ang	Ang	NNP
cord-320331-wtxja5i9	170	20	II	II	NNP
cord-320331-wtxja5i9	170	21	,	,	,
cord-320331-wtxja5i9	170	22	by	by	IN
cord-320331-wtxja5i9	170	23	catabolizing	catabolize	VBG
cord-320331-wtxja5i9	170	24	Ang	Ang	NNP
cord-320331-wtxja5i9	170	25	II	II	NNP
cord-320331-wtxja5i9	170	26	to	to	IN
cord-320331-wtxja5i9	170	27	Ang	Ang	NNP
cord-320331-wtxja5i9	170	28	(	(	-LRB-
cord-320331-wtxja5i9	170	29	1	1	CD
cord-320331-wtxja5i9	170	30	-	-	SYM
cord-320331-wtxja5i9	170	31	7	7	CD
cord-320331-wtxja5i9	170	32	)	)	-RRB-
cord-320331-wtxja5i9	170	33	to	to	TO
cord-320331-wtxja5i9	170	34	reduce	reduce	VB
cord-320331-wtxja5i9	170	35	vasoconstriction	vasoconstriction	NN
cord-320331-wtxja5i9	170	36	,	,	,
cord-320331-wtxja5i9	170	37	reduce	reduce	VB
cord-320331-wtxja5i9	170	38	sodium	sodium	NN
cord-320331-wtxja5i9	170	39	and	and	CC
cord-320331-wtxja5i9	170	40	water	water	NN
cord-320331-wtxja5i9	170	41	retention	retention	NN
cord-320331-wtxja5i9	170	42	,	,	,
cord-320331-wtxja5i9	170	43	and	and	CC
cord-320331-wtxja5i9	170	44	provide	provide	VB
cord-320331-wtxja5i9	170	45	reno	reno	NNP
cord-320331-wtxja5i9	170	46	-	-	HYPH
cord-320331-wtxja5i9	170	47	and	and	CC
cord-320331-wtxja5i9	170	48	cardio	cardio	JJ
cord-320331-wtxja5i9	170	49	-	-	HYPH
cord-320331-wtxja5i9	170	50	protective	protective	JJ
cord-320331-wtxja5i9	170	51	effects	effect	NNS
cord-320331-wtxja5i9	170	52	[	[	-LRB-
cord-320331-wtxja5i9	170	53	14	14	CD
cord-320331-wtxja5i9	170	54	,	,	,
cord-320331-wtxja5i9	170	55	19	19	CD
cord-320331-wtxja5i9	170	56	,	,	,
cord-320331-wtxja5i9	170	57	37	37	CD
cord-320331-wtxja5i9	170	58	,	,	,
cord-320331-wtxja5i9	170	59	38	38	CD
cord-320331-wtxja5i9	170	60	]	]	-RRB-
cord-320331-wtxja5i9	170	61	.	.	.
cord-320331-wtxja5i9	171	1	Hence	hence	RB
cord-320331-wtxja5i9	171	2	,	,	,
cord-320331-wtxja5i9	171	3	the	the	DT
cord-320331-wtxja5i9	171	4	reduction	reduction	NN
cord-320331-wtxja5i9	171	5	in	in	IN
cord-320331-wtxja5i9	171	6	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	171	7	E	e	NN
cord-320331-wtxja5i9	171	8	2	2	CD
cord-320331-wtxja5i9	172	1	and	and	CC
cord-320331-wtxja5i9	172	2	I	-PRON-	PRP
cord-320331-wtxja5i9	172	3	2	2	CD
cord-320331-wtxja5i9	172	4	syntheses	synthesis	NNS
cord-320331-wtxja5i9	172	5	is	be	VBZ
cord-320331-wtxja5i9	172	6	the	the	DT
cord-320331-wtxja5i9	172	7	main	main	JJ
cord-320331-wtxja5i9	172	8	mechanism	mechanism	NN
cord-320331-wtxja5i9	172	9	by	by	IN
cord-320331-wtxja5i9	172	10	which	which	WDT
cord-320331-wtxja5i9	172	11	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	172	12	directly	directly	RB
cord-320331-wtxja5i9	172	13	contribute	contribute	VBP
cord-320331-wtxja5i9	172	14	to	to	IN
cord-320331-wtxja5i9	172	15	increased	increase	VBN
cord-320331-wtxja5i9	172	16	ACE2	ACE2	NNP
cord-320331-wtxja5i9	172	17	expression	expression	NN
cord-320331-wtxja5i9	172	18	,	,	,
cord-320331-wtxja5i9	172	19	which	which	WDT
cord-320331-wtxja5i9	172	20	can	can	MD
cord-320331-wtxja5i9	172	21	be	be	VB
cord-320331-wtxja5i9	172	22	utilized	utilize	VBN
cord-320331-wtxja5i9	172	23	by	by	IN
cord-320331-wtxja5i9	172	24	SARS	SARS	NNP
cord-320331-wtxja5i9	172	25	-	-	HYPH
cord-320331-wtxja5i9	172	26	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	172	27	(	(	-LRB-
cord-320331-wtxja5i9	172	28	Fig	Fig	NNP
cord-320331-wtxja5i9	172	29	.	.	NNP
cord-320331-wtxja5i9	172	30	2	2	CD
cord-320331-wtxja5i9	172	31	)	)	-RRB-
cord-320331-wtxja5i9	172	32	.	.	.
cord-320331-wtxja5i9	173	1	studies	study	NNS
cord-320331-wtxja5i9	173	2	have	have	VBP
cord-320331-wtxja5i9	173	3	shown	show	VBN
cord-320331-wtxja5i9	173	4	that	that	IN
cord-320331-wtxja5i9	173	5	the	the	DT
cord-320331-wtxja5i9	173	6	RAAS	RAAS	NNP
cord-320331-wtxja5i9	173	7	is	be	VBZ
cord-320331-wtxja5i9	173	8	implicated	implicate	VBN
cord-320331-wtxja5i9	173	9	in	in	IN
cord-320331-wtxja5i9	173	10	acute	acute	JJ
cord-320331-wtxja5i9	173	11	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	173	12	injury	injury	NN
cord-320331-wtxja5i9	173	13	,	,	,
cord-320331-wtxja5i9	173	14	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	173	15	hypertension	hypertension	NN
cord-320331-wtxja5i9	173	16	,	,	,
cord-320331-wtxja5i9	173	17	and	and	CC
cord-320331-wtxja5i9	173	18	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	173	19	fibrosis	fibrosis	NN
cord-320331-wtxja5i9	173	20	[	[	-LRB-
cord-320331-wtxja5i9	173	21	39	39	CD
cord-320331-wtxja5i9	173	22	]	]	-RRB-
cord-320331-wtxja5i9	173	23	.	.	.
cord-320331-wtxja5i9	174	1	Likewise	likewise	RB
cord-320331-wtxja5i9	174	2	,	,	,
cord-320331-wtxja5i9	174	3	RAAS	RAAS	NNP
cord-320331-wtxja5i9	174	4	is	be	VBZ
cord-320331-wtxja5i9	174	5	indeed	indeed	RB
cord-320331-wtxja5i9	174	6	activated	activate	VBN
cord-320331-wtxja5i9	174	7	in	in	IN
cord-320331-wtxja5i9	174	8	idiopathic	idiopathic	JJ
cord-320331-wtxja5i9	174	9	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	174	10	arterial	arterial	JJ
cord-320331-wtxja5i9	174	11	hypertension	hypertension	NN
cord-320331-wtxja5i9	174	12	[	[	-LRB-
cord-320331-wtxja5i9	174	13	40	40	CD
cord-320331-wtxja5i9	174	14	]	]	-RRB-
cord-320331-wtxja5i9	174	15	,	,	,
cord-320331-wtxja5i9	174	16	and	and	CC
cord-320331-wtxja5i9	174	17	the	the	DT
cord-320331-wtxja5i9	174	18	expression	expression	NN
cord-320331-wtxja5i9	174	19	of	of	IN
cord-320331-wtxja5i9	174	20	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	174	21	receptor	receptor	NN
cord-320331-wtxja5i9	174	22	1	1	CD
cord-320331-wtxja5i9	174	23	,	,	,
cord-320331-wtxja5i9	174	24	ACE	ACE	NNP
cord-320331-wtxja5i9	174	25	,	,	,
cord-320331-wtxja5i9	174	26	and	and	CC
cord-320331-wtxja5i9	174	27	ACE2	ACE2	NNP
cord-320331-wtxja5i9	174	28	is	be	VBZ
cord-320331-wtxja5i9	174	29	upregulated	upregulate	VBN
cord-320331-wtxja5i9	174	30	in	in	IN
cord-320331-wtxja5i9	174	31	the	the	DT
cord-320331-wtxja5i9	174	32	lungs	lung	NNS
cord-320331-wtxja5i9	174	33	as	as	IN
cord-320331-wtxja5i9	174	34	a	a	DT
cord-320331-wtxja5i9	174	35	response	response	NN
cord-320331-wtxja5i9	174	36	to	to	IN
cord-320331-wtxja5i9	174	37	lung	lung	NN
cord-320331-wtxja5i9	174	38	pathology	pathology	NN
cord-320331-wtxja5i9	174	39	[	[	-LRB-
cord-320331-wtxja5i9	174	40	39	39	CD
cord-320331-wtxja5i9	174	41	,	,	,
cord-320331-wtxja5i9	174	42	41	41	CD
cord-320331-wtxja5i9	174	43	,	,	,
cord-320331-wtxja5i9	174	44	42	42	CD
cord-320331-wtxja5i9	174	45	]	]	-RRB-
cord-320331-wtxja5i9	174	46	.	.	.
cord-320331-wtxja5i9	175	1	Hence	hence	RB
cord-320331-wtxja5i9	175	2	,	,	,
cord-320331-wtxja5i9	175	3	ACE2	ACE2	NNP
cord-320331-wtxja5i9	175	4	may	may	MD
cord-320331-wtxja5i9	175	5	also	also	RB
cord-320331-wtxja5i9	175	6	be	be	VB
cord-320331-wtxja5i9	175	7	increased	increase	VBN
cord-320331-wtxja5i9	175	8	in	in	IN
cord-320331-wtxja5i9	175	9	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	175	10	tissues	tissue	NNS
cord-320331-wtxja5i9	175	11	secondary	secondary	JJ
cord-320331-wtxja5i9	175	12	to	to	IN
cord-320331-wtxja5i9	175	13	ACE	ace	NN
cord-320331-wtxja5i9	175	14	-	-	HYPH
cord-320331-wtxja5i9	175	15	induced	induce	VBN
cord-320331-wtxja5i9	175	16	promotion	promotion	NN
cord-320331-wtxja5i9	175	17	of	of	IN
cord-320331-wtxja5i9	175	18	the	the	DT
cord-320331-wtxja5i9	175	19	RAAS	raa	NNS
cord-320331-wtxja5i9	175	20	.	.	.
cord-320331-wtxja5i9	176	1	Further	further	RB
cord-320331-wtxja5i9	176	2	,	,	,
cord-320331-wtxja5i9	176	3	it	-PRON-	PRP
cord-320331-wtxja5i9	176	4	has	have	VBZ
cord-320331-wtxja5i9	176	5	been	be	VBN
cord-320331-wtxja5i9	176	6	shown	show	VBN
cord-320331-wtxja5i9	176	7	that	that	IN
cord-320331-wtxja5i9	176	8	COX-2	COX-2	NNP
cord-320331-wtxja5i9	176	9	and	and	CC
cord-320331-wtxja5i9	176	10	PGE	PGE	NNP
cord-320331-wtxja5i9	176	11	2	2	CD
cord-320331-wtxja5i9	176	12	mediate	mediate	VBP
cord-320331-wtxja5i9	176	13	an	an	DT
cord-320331-wtxja5i9	176	14	antiviral	antiviral	JJ
cord-320331-wtxja5i9	176	15	response	response	NN
cord-320331-wtxja5i9	176	16	in	in	IN
cord-320331-wtxja5i9	176	17	lung	lung	NN
cord-320331-wtxja5i9	176	18	epithelial	epithelial	NN
cord-320331-wtxja5i9	176	19	cells	cell	NNS
cord-320331-wtxja5i9	176	20	infected	infect	VBN
cord-320331-wtxja5i9	176	21	with	with	IN
cord-320331-wtxja5i9	176	22	human	human	JJ
cord-320331-wtxja5i9	176	23	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	176	24	,	,	,
cord-320331-wtxja5i9	176	25	and	and	CC
cord-320331-wtxja5i9	176	26	their	-PRON-	PRP$
cord-320331-wtxja5i9	176	27	expression	expression	NN
cord-320331-wtxja5i9	176	28	results	result	NNS
cord-320331-wtxja5i9	176	29	in	in	IN
cord-320331-wtxja5i9	176	30	decreased	decrease	VBN
cord-320331-wtxja5i9	176	31	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	176	32	replication	replication	NN
cord-320331-wtxja5i9	176	33	[	[	-LRB-
cord-320331-wtxja5i9	176	34	43	43	CD
cord-320331-wtxja5i9	176	35	]	]	-RRB-
cord-320331-wtxja5i9	176	36	.	.	.
cord-320331-wtxja5i9	177	1	Similarly	similarly	RB
cord-320331-wtxja5i9	177	2	,	,	,
cord-320331-wtxja5i9	177	3	PGD	PGD	NNP
cord-320331-wtxja5i9	177	4	2	2	CD
cord-320331-wtxja5i9	177	5	,	,	,
cord-320331-wtxja5i9	177	6	a	a	DT
cord-320331-wtxja5i9	177	7	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	177	8	known	know	VBN
cord-320331-wtxja5i9	177	9	to	to	TO
cord-320331-wtxja5i9	177	10	be	be	VB
cord-320331-wtxja5i9	177	11	expressed	express	VBN
cord-320331-wtxja5i9	177	12	in	in	IN
cord-320331-wtxja5i9	177	13	the	the	DT
cord-320331-wtxja5i9	177	14	brain	brain	NN
cord-320331-wtxja5i9	177	15	and	and	CC
cord-320331-wtxja5i9	177	16	airways	airway	NNS
cord-320331-wtxja5i9	177	17	,	,	,
cord-320331-wtxja5i9	177	18	mediate	mediate	VB
cord-320331-wtxja5i9	177	19	an	an	DT
cord-320331-wtxja5i9	177	20	anti	anti	JJ
cord-320331-wtxja5i9	177	21	-	-	JJ
cord-320331-wtxja5i9	177	22	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	177	23	response	response	NN
cord-320331-wtxja5i9	177	24	that	that	WDT
cord-320331-wtxja5i9	177	25	may	may	MD
cord-320331-wtxja5i9	177	26	protect	protect	VB
cord-320331-wtxja5i9	177	27	against	against	IN
cord-320331-wtxja5i9	177	28	acute	acute	JJ
cord-320331-wtxja5i9	177	29	respiratory	respiratory	JJ
cord-320331-wtxja5i9	177	30	distress	distress	NN
cord-320331-wtxja5i9	177	31	and	and	CC
cord-320331-wtxja5i9	177	32	acute	acute	JJ
cord-320331-wtxja5i9	177	33	lung	lung	NN
cord-320331-wtxja5i9	177	34	injury	injury	NN
cord-320331-wtxja5i9	177	35	[	[	-LRB-
cord-320331-wtxja5i9	177	36	44	44	CD
cord-320331-wtxja5i9	177	37	]	]	-RRB-
cord-320331-wtxja5i9	177	38	.	.	.
cord-320331-wtxja5i9	178	1	Hence	hence	RB
cord-320331-wtxja5i9	178	2	,	,	,
cord-320331-wtxja5i9	178	3	the	the	DT
cord-320331-wtxja5i9	178	4	use	use	NN
cord-320331-wtxja5i9	178	5	of	of	IN
cord-320331-wtxja5i9	178	6	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	178	7	not	not	RB
cord-320331-wtxja5i9	178	8	only	only	RB
cord-320331-wtxja5i9	178	9	decreases	decrease	VBZ
cord-320331-wtxja5i9	178	10	PGE	PGE	NNP
cord-320331-wtxja5i9	178	11	2and	2and	CD
cord-320331-wtxja5i9	178	12	PGI	PGI	NNP
cord-320331-wtxja5i9	178	13	2	2	CD
cord-320331-wtxja5i9	178	14	-mediated	-mediated	JJ
cord-320331-wtxja5i9	178	15	regulation	regulation	NN
cord-320331-wtxja5i9	178	16	of	of	IN
cord-320331-wtxja5i9	178	17	kidney	kidney	NN
cord-320331-wtxja5i9	178	18	function	function	NN
cord-320331-wtxja5i9	178	19	,	,	,
cord-320331-wtxja5i9	178	20	but	but	CC
cord-320331-wtxja5i9	178	21	also	also	RB
cord-320331-wtxja5i9	178	22	PGD	PGD	NNP
cord-320331-wtxja5i9	178	23	2	2	CD
cord-320331-wtxja5i9	178	24	-mediated	-mediated	JJ
cord-320331-wtxja5i9	178	25	protection	protection	NN
cord-320331-wtxja5i9	178	26	against	against	IN
cord-320331-wtxja5i9	178	27	acute	acute	JJ
cord-320331-wtxja5i9	178	28	lung	lung	NN
cord-320331-wtxja5i9	178	29	injury	injury	NN
cord-320331-wtxja5i9	178	30	and	and	CC
cord-320331-wtxja5i9	178	31	PGE	PGE	NNP
cord-320331-wtxja5i9	178	32	2	2	CD
cord-320331-wtxja5i9	178	33	-mediated	-mediated	JJ
cord-320331-wtxja5i9	178	34	antiviral	antiviral	JJ
cord-320331-wtxja5i9	178	35	responses	response	NNS
cord-320331-wtxja5i9	178	36	,	,	,
cord-320331-wtxja5i9	178	37	which	which	WDT
cord-320331-wtxja5i9	178	38	may	may	MD
cord-320331-wtxja5i9	178	39	lead	lead	VB
cord-320331-wtxja5i9	178	40	to	to	IN
cord-320331-wtxja5i9	178	41	an	an	DT
cord-320331-wtxja5i9	178	42	enhanced	enhance	VBN
cord-320331-wtxja5i9	178	43	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	178	44	replication	replication	NN
cord-320331-wtxja5i9	178	45	in	in	IN
cord-320331-wtxja5i9	178	46	the	the	DT
cord-320331-wtxja5i9	178	47	lung	lung	NN
cord-320331-wtxja5i9	178	48	epithelia	epithelium	NNS
cord-320331-wtxja5i9	178	49	.	.	.
cord-320331-wtxja5i9	179	1	A	a	DT
cord-320331-wtxja5i9	179	2	review	review	NN
cord-320331-wtxja5i9	179	3	of	of	IN
cord-320331-wtxja5i9	179	4	clinical	clinical	JJ
cord-320331-wtxja5i9	179	5	evidence	evidence	NN
cord-320331-wtxja5i9	179	6	has	have	VBZ
cord-320331-wtxja5i9	179	7	shown	show	VBN
cord-320331-wtxja5i9	179	8	that	that	IN
cord-320331-wtxja5i9	179	9	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	179	10	and	and	CC
cord-320331-wtxja5i9	179	11	naproxen	naproxen	NN
cord-320331-wtxja5i9	179	12	improved	improve	VBD
cord-320331-wtxja5i9	179	13	the	the	DT
cord-320331-wtxja5i9	179	14	symptoms	symptom	NNS
cord-320331-wtxja5i9	179	15	of	of	IN
cord-320331-wtxja5i9	179	16	influenza	influenza	NN
cord-320331-wtxja5i9	179	17	,	,	,
cord-320331-wtxja5i9	179	18	and	and	CC
cord-320331-wtxja5i9	179	19	naproxen	naproxen	NN
cord-320331-wtxja5i9	179	20	combined	combine	VBN
cord-320331-wtxja5i9	179	21	with	with	IN
cord-320331-wtxja5i9	179	22	clarithromycin	clarithromycin	NNS
cord-320331-wtxja5i9	179	23	and	and	CC
cord-320331-wtxja5i9	179	24	oseltamivir	oseltamivir	NN
cord-320331-wtxja5i9	179	25	reduced	reduce	VBD
cord-320331-wtxja5i9	179	26	both	both	CC
cord-320331-wtxja5i9	179	27	the	the	DT
cord-320331-wtxja5i9	179	28	rate	rate	NN
cord-320331-wtxja5i9	179	29	and	and	CC
cord-320331-wtxja5i9	179	30	the	the	DT
cord-320331-wtxja5i9	179	31	duration	duration	NN
cord-320331-wtxja5i9	179	32	of	of	IN
cord-320331-wtxja5i9	179	33	hospitalization	hospitalization	NN
cord-320331-wtxja5i9	179	34	of	of	IN
cord-320331-wtxja5i9	179	35	patients	patient	NNS
cord-320331-wtxja5i9	179	36	with	with	IN
cord-320331-wtxja5i9	179	37	influenza	influenza	NN
cord-320331-wtxja5i9	179	38	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	179	39	.	.	.
cord-320331-wtxja5i9	180	1	However	however	RB
cord-320331-wtxja5i9	180	2	,	,	,
cord-320331-wtxja5i9	180	3	no	no	DT
cord-320331-wtxja5i9	180	4	evidence	evidence	NN
cord-320331-wtxja5i9	180	5	was	be	VBD
cord-320331-wtxja5i9	180	6	provided	provide	VBN
cord-320331-wtxja5i9	180	7	for	for	IN
cord-320331-wtxja5i9	180	8	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	180	9	[	[	-LRB-
cord-320331-wtxja5i9	180	10	102	102	CD
cord-320331-wtxja5i9	180	11	]	]	-RRB-
cord-320331-wtxja5i9	180	12	.	.	.
cord-320331-wtxja5i9	181	1	The	the	DT
cord-320331-wtxja5i9	181	2	observed	observed	JJ
cord-320331-wtxja5i9	181	3	benefits	benefit	NNS
cord-320331-wtxja5i9	181	4	in	in	IN
cord-320331-wtxja5i9	181	5	influenza	influenza	NN
cord-320331-wtxja5i9	181	6	infection	infection	NN
cord-320331-wtxja5i9	181	7	may	may	MD
cord-320331-wtxja5i9	181	8	be	be	VB
cord-320331-wtxja5i9	181	9	due	due	JJ
cord-320331-wtxja5i9	181	10	to	to	IN
cord-320331-wtxja5i9	181	11	the	the	DT
cord-320331-wtxja5i9	181	12	reduction	reduction	NN
cord-320331-wtxja5i9	181	13	in	in	IN
cord-320331-wtxja5i9	181	14	airway	airway	NN
cord-320331-wtxja5i9	181	15	inflammation	inflammation	NN
cord-320331-wtxja5i9	181	16	which	which	WDT
cord-320331-wtxja5i9	181	17	is	be	VBZ
cord-320331-wtxja5i9	181	18	common	common	JJ
cord-320331-wtxja5i9	181	19	in	in	IN
cord-320331-wtxja5i9	181	20	colds	cold	NNS
cord-320331-wtxja5i9	181	21	,	,	,
cord-320331-wtxja5i9	181	22	and	and	CC
cord-320331-wtxja5i9	181	23	which	which	WDT
cord-320331-wtxja5i9	181	24	is	be	VBZ
cord-320331-wtxja5i9	181	25	also	also	RB
cord-320331-wtxja5i9	181	26	observed	observe	VBN
cord-320331-wtxja5i9	181	27	in	in	IN
cord-320331-wtxja5i9	181	28	severe	severe	JJ
cord-320331-wtxja5i9	181	29	influenza	influenza	NN
cord-320331-wtxja5i9	181	30	.	.	.
cord-320331-wtxja5i9	182	1	However	however	RB
cord-320331-wtxja5i9	182	2	,	,	,
cord-320331-wtxja5i9	182	3	regarding	regard	VBG
cord-320331-wtxja5i9	182	4	viral	viral	JJ
cord-320331-wtxja5i9	182	5	entry	entry	NN
cord-320331-wtxja5i9	182	6	and	and	CC
cord-320331-wtxja5i9	182	7	replication	replication	NN
cord-320331-wtxja5i9	182	8	,	,	,
cord-320331-wtxja5i9	182	9	this	this	DT
cord-320331-wtxja5i9	182	10	clinical	clinical	JJ
cord-320331-wtxja5i9	182	11	evidence	evidence	NN
cord-320331-wtxja5i9	182	12	does	do	VBZ
cord-320331-wtxja5i9	182	13	not	not	RB
cord-320331-wtxja5i9	182	14	directly	directly	RB
cord-320331-wtxja5i9	182	15	support	support	VB
cord-320331-wtxja5i9	182	16	nor	nor	CC
cord-320331-wtxja5i9	182	17	reject	reject	VBP
cord-320331-wtxja5i9	182	18	any	any	DT
cord-320331-wtxja5i9	182	19	of	of	IN
cord-320331-wtxja5i9	182	20	the	the	DT
cord-320331-wtxja5i9	182	21	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	182	22	discussed	discuss	VBN
cord-320331-wtxja5i9	182	23	,	,	,
cord-320331-wtxja5i9	182	24	especially	especially	RB
cord-320331-wtxja5i9	182	25	with	with	IN
cord-320331-wtxja5i9	182	26	regards	regard	NNS
cord-320331-wtxja5i9	182	27	to	to	IN
cord-320331-wtxja5i9	182	28	SARS	SARS	NNP
cord-320331-wtxja5i9	182	29	-	-	HYPH
cord-320331-wtxja5i9	182	30	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	182	31	infection	infection	NN
cord-320331-wtxja5i9	182	32	.	.	.
cord-320331-wtxja5i9	183	1	A	a	DT
cord-320331-wtxja5i9	183	2	similar	similar	JJ
cord-320331-wtxja5i9	183	3	systematic	systematic	JJ
cord-320331-wtxja5i9	183	4	review	review	NN
cord-320331-wtxja5i9	183	5	of	of	IN
cord-320331-wtxja5i9	183	6	various	various	JJ
cord-320331-wtxja5i9	183	7	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	183	8	,	,	,
cord-320331-wtxja5i9	183	9	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	183	10	,	,	,
cord-320331-wtxja5i9	183	11	and	and	CC
cord-320331-wtxja5i9	183	12	specific	specific	JJ
cord-320331-wtxja5i9	183	13	immunosuppressive	immunosuppressive	JJ
cord-320331-wtxja5i9	183	14	or	or	CC
cord-320331-wtxja5i9	183	15	immunestimulating	immunestimulate	VBG
cord-320331-wtxja5i9	183	16	drugs	drug	NNS
cord-320331-wtxja5i9	183	17	have	have	VBP
cord-320331-wtxja5i9	183	18	shown	show	VBN
cord-320331-wtxja5i9	183	19	no	no	DT
cord-320331-wtxja5i9	183	20	strong	strong	JJ
cord-320331-wtxja5i9	183	21	evidence	evidence	NN
cord-320331-wtxja5i9	183	22	supporting	support	VBG
cord-320331-wtxja5i9	183	23	the	the	DT
cord-320331-wtxja5i9	183	24	use	use	NN
cord-320331-wtxja5i9	183	25	of	of	IN
cord-320331-wtxja5i9	183	26	NSAIDs	NSAIDs	NNP
cord-320331-wtxja5i9	183	27	for	for	IN
cord-320331-wtxja5i9	183	28	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	183	29	;	;	:
cord-320331-wtxja5i9	183	30	however	however	RB
cord-320331-wtxja5i9	183	31	,	,	,
cord-320331-wtxja5i9	183	32	indomethacin	indomethacin	NNP
cord-320331-wtxja5i9	183	33	was	be	VBD
cord-320331-wtxja5i9	183	34	noted	note	VBN
cord-320331-wtxja5i9	183	35	to	to	TO
cord-320331-wtxja5i9	183	36	have	have	VB
cord-320331-wtxja5i9	183	37	shown	show	VBN
cord-320331-wtxja5i9	183	38	direct	direct	JJ
cord-320331-wtxja5i9	183	39	antiviral	antiviral	JJ
cord-320331-wtxja5i9	183	40	activity	activity	NN
cord-320331-wtxja5i9	183	41	against	against	IN
cord-320331-wtxja5i9	183	42	SARS	SARS	NNP
cord-320331-wtxja5i9	183	43	-	-	HYPH
cord-320331-wtxja5i9	183	44	CoV	CoV	NNP
cord-320331-wtxja5i9	183	45	and	and	CC
cord-320331-wtxja5i9	183	46	canine	canine	JJ
cord-320331-wtxja5i9	183	47	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	183	48	(	(	-LRB-
cord-320331-wtxja5i9	183	49	CCoV	ccov	ADD
cord-320331-wtxja5i9	183	50	)	)	-RRB-
cord-320331-wtxja5i9	184	1	in	in	IN
cord-320331-wtxja5i9	184	2	vitro	vitro	FW
cord-320331-wtxja5i9	184	3	[	[	-LRB-
cord-320331-wtxja5i9	184	4	103	103	CD
cord-320331-wtxja5i9	184	5	]	]	-RRB-
cord-320331-wtxja5i9	184	6	.	.	.
cord-320331-wtxja5i9	185	1	The	the	DT
cord-320331-wtxja5i9	185	2	resulting	result	VBG
cord-320331-wtxja5i9	185	3	benefit	benefit	NN
cord-320331-wtxja5i9	185	4	is	be	VBZ
cord-320331-wtxja5i9	185	5	not	not	RB
cord-320331-wtxja5i9	185	6	expected	expect	VBN
cord-320331-wtxja5i9	185	7	to	to	TO
cord-320331-wtxja5i9	185	8	contradict	contradict	VB
cord-320331-wtxja5i9	185	9	the	the	DT
cord-320331-wtxja5i9	185	10	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	185	11	discussed	discuss	VBN
cord-320331-wtxja5i9	185	12	;	;	:
cord-320331-wtxja5i9	185	13	J	J	NNP
cord-320331-wtxja5i9	185	14	o	o	NN
cord-320331-wtxja5i9	185	15	u	u	NN
cord-320331-wtxja5i9	185	16	r	r	NN
cord-320331-wtxja5i9	185	17	n	n	NN
cord-320331-wtxja5i9	185	18	a	a	DT
cord-320331-wtxja5i9	185	19	l	l	NN
cord-320331-wtxja5i9	185	20	P	p	NN
cord-320331-wtxja5i9	185	21	r	r	NN
cord-320331-wtxja5i9	185	22	e	e	NN
cord-320331-wtxja5i9	185	23	-p	-p	NN
cord-320331-wtxja5i9	186	1	r	r	LS
cord-320331-wtxja5i9	187	1	o	o	UH
cord-320331-wtxja5i9	188	1	o	o	UH
cord-320331-wtxja5i9	188	2	f	f	NNP
cord-320331-wtxja5i9	188	3	rather	rather	RB
cord-320331-wtxja5i9	188	4	,	,	,
cord-320331-wtxja5i9	188	5	it	-PRON-	PRP
cord-320331-wtxja5i9	188	6	must	must	MD
cord-320331-wtxja5i9	188	7	have	have	VB
cord-320331-wtxja5i9	188	8	been	be	VBN
cord-320331-wtxja5i9	188	9	a	a	DT
cord-320331-wtxja5i9	188	10	function	function	NN
cord-320331-wtxja5i9	188	11	of	of	IN
cord-320331-wtxja5i9	188	12	the	the	DT
cord-320331-wtxja5i9	188	13	structure	structure	NN
cord-320331-wtxja5i9	188	14	of	of	IN
cord-320331-wtxja5i9	188	15	indomethacin	indomethacin	NN
cord-320331-wtxja5i9	188	16	,	,	,
cord-320331-wtxja5i9	188	17	which	which	WDT
cord-320331-wtxja5i9	188	18	is	be	VBZ
cord-320331-wtxja5i9	188	19	reflective	reflective	JJ
cord-320331-wtxja5i9	188	20	of	of	IN
cord-320331-wtxja5i9	188	21	the	the	DT
cord-320331-wtxja5i9	188	22	authors	author	NNS
cord-320331-wtxja5i9	188	23	'	'	POS
cord-320331-wtxja5i9	188	24	comment	comment	NN
cord-320331-wtxja5i9	188	25	that	that	IN
cord-320331-wtxja5i9	188	26	the	the	DT
cord-320331-wtxja5i9	188	27	results	result	NNS
cord-320331-wtxja5i9	188	28	were	be	VBD
cord-320331-wtxja5i9	188	29	unexpected	unexpected	JJ
cord-320331-wtxja5i9	188	30	since	since	IN
cord-320331-wtxja5i9	188	31	indomethacin	indomethacin	NN
cord-320331-wtxja5i9	188	32	is	be	VBZ
cord-320331-wtxja5i9	188	33	a	a	DT
cord-320331-wtxja5i9	188	34	COX	COX	NNP
cord-320331-wtxja5i9	188	35	inhibitor	inhibitor	NN
cord-320331-wtxja5i9	188	36	[	[	-LRB-
cord-320331-wtxja5i9	188	37	104	104	CD
cord-320331-wtxja5i9	188	38	]	]	-RRB-
cord-320331-wtxja5i9	188	39	.	.	.
cord-320331-wtxja5i9	189	1	A	a	DT
cord-320331-wtxja5i9	189	2	retrospective	retrospective	JJ
cord-320331-wtxja5i9	189	3	cohort	cohort	NN
cord-320331-wtxja5i9	189	4	study	study	NN
cord-320331-wtxja5i9	189	5	published	publish	VBN
cord-320331-wtxja5i9	189	6	in	in	IN
cord-320331-wtxja5i9	189	7	2005	2005	CD
cord-320331-wtxja5i9	189	8	showed	show	VBD
cord-320331-wtxja5i9	189	9	that	that	IN
cord-320331-wtxja5i9	189	10	patients	patient	NNS
cord-320331-wtxja5i9	189	11	in	in	IN
cord-320331-wtxja5i9	189	12	Hong	Hong	NNP
cord-320331-wtxja5i9	189	13	Kong	Kong	NNP
cord-320331-wtxja5i9	189	14	infected	infect	VBN
cord-320331-wtxja5i9	189	15	with	with	IN
cord-320331-wtxja5i9	189	16	SARS	SARS	NNP
cord-320331-wtxja5i9	189	17	-	-	HYPH
cord-320331-wtxja5i9	189	18	CoV	CoV	NNP
cord-320331-wtxja5i9	189	19	,	,	,
cord-320331-wtxja5i9	189	20	which	which	WDT
cord-320331-wtxja5i9	189	21	were	be	VBD
cord-320331-wtxja5i9	189	22	given	give	VBN
cord-320331-wtxja5i9	189	23	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	189	24	to	to	TO
cord-320331-wtxja5i9	189	25	manage	manage	VB
cord-320331-wtxja5i9	189	26	acute	acute	JJ
cord-320331-wtxja5i9	189	27	respiratory	respiratory	JJ
cord-320331-wtxja5i9	189	28	distress	distress	NN
cord-320331-wtxja5i9	189	29	,	,	,
cord-320331-wtxja5i9	189	30	experienced	experience	VBD
cord-320331-wtxja5i9	189	31	higher	high	JJR
cord-320331-wtxja5i9	189	32	rates	rate	NNS
cord-320331-wtxja5i9	189	33	of	of	IN
cord-320331-wtxja5i9	189	34	adverse	adverse	JJ
cord-320331-wtxja5i9	189	35	outcomes	outcome	NNS
cord-320331-wtxja5i9	189	36	despite	despite	IN
cord-320331-wtxja5i9	189	37	favorable	favorable	JJ
cord-320331-wtxja5i9	189	38	baseline	baseline	JJ
cord-320331-wtxja5i9	189	39	characteristics	characteristic	NNS
cord-320331-wtxja5i9	189	40	.	.	.
cord-320331-wtxja5i9	190	1	Further	further	RB
cord-320331-wtxja5i9	190	2	,	,	,
cord-320331-wtxja5i9	190	3	analysis	analysis	NN
cord-320331-wtxja5i9	190	4	showed	show	VBD
cord-320331-wtxja5i9	190	5	that	that	IN
cord-320331-wtxja5i9	190	6	SARS	SARS	NNP
cord-320331-wtxja5i9	190	7	patients	patient	NNS
cord-320331-wtxja5i9	190	8	treated	treat	VBN
cord-320331-wtxja5i9	190	9	with	with	IN
cord-320331-wtxja5i9	190	10	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	190	11	(	(	-LRB-
cord-320331-wtxja5i9	190	12	hydrocortisone	hydrocortisone	NNP
cord-320331-wtxja5i9	190	13	,	,	,
cord-320331-wtxja5i9	190	14	methylprednisolone	methylprednisolone	NNP
cord-320331-wtxja5i9	190	15	)	)	-RRB-
cord-320331-wtxja5i9	190	16	were	be	VBD
cord-320331-wtxja5i9	190	17	at	at	IN
cord-320331-wtxja5i9	190	18	a	a	DT
cord-320331-wtxja5i9	190	19	20.7-fold	20.7-fold	CD
cord-320331-wtxja5i9	190	20	higher	high	JJR
cord-320331-wtxja5i9	190	21	risk	risk	NN
cord-320331-wtxja5i9	190	22	of	of	IN
cord-320331-wtxja5i9	190	23	ICU	ICU	NNP
cord-320331-wtxja5i9	190	24	admissions	admission	NNS
cord-320331-wtxja5i9	190	25	or	or	CC
cord-320331-wtxja5i9	190	26	mortality	mortality	NN
cord-320331-wtxja5i9	190	27	,	,	,
cord-320331-wtxja5i9	190	28	independent	independent	JJ
cord-320331-wtxja5i9	190	29	of	of	IN
cord-320331-wtxja5i9	190	30	age	age	NN
cord-320331-wtxja5i9	190	31	and	and	CC
cord-320331-wtxja5i9	190	32	severity	severity	NN
cord-320331-wtxja5i9	190	33	of	of	IN
cord-320331-wtxja5i9	190	34	disease	disease	NN
cord-320331-wtxja5i9	190	35	[	[	-LRB-
cord-320331-wtxja5i9	190	36	45	45	CD
cord-320331-wtxja5i9	190	37	]	]	-RRB-
cord-320331-wtxja5i9	190	38	.	.	.
cord-320331-wtxja5i9	191	1	This	this	DT
cord-320331-wtxja5i9	191	2	study	study	NN
cord-320331-wtxja5i9	191	3	alone	alone	RB
cord-320331-wtxja5i9	191	4	,	,	,
cord-320331-wtxja5i9	191	5	albeit	albeit	IN
cord-320331-wtxja5i9	191	6	based	base	VBN
cord-320331-wtxja5i9	191	7	on	on	IN
cord-320331-wtxja5i9	191	8	SARS	SARS	NNP
cord-320331-wtxja5i9	191	9	-	-	HYPH
cord-320331-wtxja5i9	191	10	CoV	CoV	NNP
cord-320331-wtxja5i9	191	11	,	,	,
cord-320331-wtxja5i9	191	12	showed	show	VBD
cord-320331-wtxja5i9	191	13	that	that	IN
cord-320331-wtxja5i9	191	14	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	191	15	use	use	NN
cord-320331-wtxja5i9	191	16	may	may	MD
cord-320331-wtxja5i9	191	17	in	in	IN
cord-320331-wtxja5i9	191	18	fact	fact	NN
cord-320331-wtxja5i9	191	19	increase	increase	VB
cord-320331-wtxja5i9	191	20	the	the	DT
cord-320331-wtxja5i9	191	21	risk	risk	NN
cord-320331-wtxja5i9	191	22	of	of	IN
cord-320331-wtxja5i9	191	23	unfavorable	unfavorable	JJ
cord-320331-wtxja5i9	191	24	outcomes	outcome	NNS
cord-320331-wtxja5i9	191	25	for	for	IN
cord-320331-wtxja5i9	191	26	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	191	27	-	-	HYPH
cord-320331-wtxja5i9	191	28	infected	infect	VBN
cord-320331-wtxja5i9	191	29	patients	patient	NNS
cord-320331-wtxja5i9	191	30	.	.	.
cord-320331-wtxja5i9	192	1	However	however	RB
cord-320331-wtxja5i9	192	2	,	,	,
cord-320331-wtxja5i9	192	3	data	datum	NNS
cord-320331-wtxja5i9	192	4	supporting	support	VBG
cord-320331-wtxja5i9	192	5	the	the	DT
cord-320331-wtxja5i9	192	6	validity	validity	NN
cord-320331-wtxja5i9	192	7	of	of	IN
cord-320331-wtxja5i9	192	8	this	this	DT
cord-320331-wtxja5i9	192	9	conclusion	conclusion	NN
cord-320331-wtxja5i9	192	10	on	on	IN
cord-320331-wtxja5i9	192	11	other	other	JJ
cord-320331-wtxja5i9	192	12	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	192	13	infections	infection	NNS
cord-320331-wtxja5i9	192	14	are	be	VBP
cord-320331-wtxja5i9	192	15	indeed	indeed	RB
cord-320331-wtxja5i9	192	16	warranted	warrant	VBN
cord-320331-wtxja5i9	192	17	.	.	.
cord-320331-wtxja5i9	193	1	To	to	TO
cord-320331-wtxja5i9	193	2	note	note	VB
cord-320331-wtxja5i9	193	3	,	,	,
cord-320331-wtxja5i9	193	4	a	a	DT
cord-320331-wtxja5i9	193	5	systematic	systematic	JJ
cord-320331-wtxja5i9	193	6	review	review	NN
cord-320331-wtxja5i9	193	7	and	and	CC
cord-320331-wtxja5i9	193	8	meta	meta	NNP
cord-320331-wtxja5i9	193	9	-	-	HYPH
cord-320331-wtxja5i9	193	10	analysis	analysis	NN
cord-320331-wtxja5i9	193	11	of	of	IN
cord-320331-wtxja5i9	193	12	15	15	CD
cord-320331-wtxja5i9	193	13	studies	study	NNS
cord-320331-wtxja5i9	193	14	on	on	IN
cord-320331-wtxja5i9	193	15	the	the	DT
cord-320331-wtxja5i9	193	16	management	management	NN
cord-320331-wtxja5i9	193	17	of	of	IN
cord-320331-wtxja5i9	193	18	coronavirus	coronavirus	NNP
cord-320331-wtxja5i9	193	19	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	193	20	showed	show	VBD
cord-320331-wtxja5i9	193	21	that	that	IN
cord-320331-wtxja5i9	193	22	patients	patient	NNS
cord-320331-wtxja5i9	193	23	with	with	IN
cord-320331-wtxja5i9	193	24	severe	severe	JJ
cord-320331-wtxja5i9	193	25	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	193	26	symptoms	symptom	NNS
cord-320331-wtxja5i9	193	27	were	be	VBD
cord-320331-wtxja5i9	193	28	more	more	RBR
cord-320331-wtxja5i9	193	29	likely	likely	JJ
cord-320331-wtxja5i9	193	30	to	to	TO
cord-320331-wtxja5i9	193	31	require	require	VB
cord-320331-wtxja5i9	193	32	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	193	33	therapy	therapy	NN
cord-320331-wtxja5i9	193	34	(	(	-LRB-
cord-320331-wtxja5i9	193	35	RR	RR	NNP
cord-320331-wtxja5i9	193	36	1.56	1.56	CD
cord-320331-wtxja5i9	193	37	;	;	:
cord-320331-wtxja5i9	193	38	CI	CI	NNP
cord-320331-wtxja5i9	193	39	1.28	1.28	CD
cord-320331-wtxja5i9	193	40	-	-	HYPH
cord-320331-wtxja5i9	193	41	1.90	1.90	CD
cord-320331-wtxja5i9	193	42	)	)	-RRB-
cord-320331-wtxja5i9	193	43	,	,	,
cord-320331-wtxja5i9	193	44	but	but	CC
cord-320331-wtxja5i9	193	45	that	that	IN
cord-320331-wtxja5i9	193	46	they	-PRON-	PRP
cord-320331-wtxja5i9	193	47	were	be	VBD
cord-320331-wtxja5i9	193	48	also	also	RB
cord-320331-wtxja5i9	193	49	twice	twice	RB
cord-320331-wtxja5i9	193	50	as	as	RB
cord-320331-wtxja5i9	193	51	likely	likely	JJ
cord-320331-wtxja5i9	193	52	to	to	TO
cord-320331-wtxja5i9	193	53	contract	contract	VB
cord-320331-wtxja5i9	193	54	bacterial	bacterial	JJ
cord-320331-wtxja5i9	193	55	infection	infection	NN
cord-320331-wtxja5i9	193	56	(	(	-LRB-
cord-320331-wtxja5i9	193	57	RR	RR	NNP
cord-320331-wtxja5i9	193	58	2.08	2.08	CD
cord-320331-wtxja5i9	193	59	;	;	:
cord-320331-wtxja5i9	193	60	CI	CI	NNP
cord-320331-wtxja5i9	193	61	1.54	1.54	CD
cord-320331-wtxja5i9	193	62	-	-	HYPH
cord-320331-wtxja5i9	193	63	2.81	2.81	CD
cord-320331-wtxja5i9	193	64	)	)	-RRB-
cord-320331-wtxja5i9	193	65	and	and	CC
cord-320331-wtxja5i9	193	66	were	be	VBD
cord-320331-wtxja5i9	193	67	twice	twice	RB
cord-320331-wtxja5i9	193	68	as	as	RB
cord-320331-wtxja5i9	193	69	likely	likely	JJ
cord-320331-wtxja5i9	193	70	to	to	TO
cord-320331-wtxja5i9	193	71	succumb	succumb	VB
cord-320331-wtxja5i9	193	72	to	to	IN
cord-320331-wtxja5i9	193	73	the	the	DT
cord-320331-wtxja5i9	193	74	disease	disease	NN
cord-320331-wtxja5i9	193	75	(	(	-LRB-
cord-320331-wtxja5i9	193	76	RR	RR	NNP
cord-320331-wtxja5i9	193	77	2.11	2.11	CD
cord-320331-wtxja5i9	193	78	;	;	:
cord-320331-wtxja5i9	193	79	CI	CI	NNP
cord-320331-wtxja5i9	193	80	1.13	1.13	CD
cord-320331-wtxja5i9	193	81	-	-	HYPH
cord-320331-wtxja5i9	193	82	3.94	3.94	CD
cord-320331-wtxja5i9	193	83	)	)	-RRB-
cord-320331-wtxja5i9	193	84	[	[	-LRB-
cord-320331-wtxja5i9	193	85	105	105	CD
cord-320331-wtxja5i9	193	86	]	]	-RRB-
cord-320331-wtxja5i9	193	87	.	.	.
cord-320331-wtxja5i9	194	1	However	however	RB
cord-320331-wtxja5i9	194	2	,	,	,
cord-320331-wtxja5i9	194	3	this	this	DT
cord-320331-wtxja5i9	194	4	systematic	systematic	JJ
cord-320331-wtxja5i9	194	5	review	review	NN
cord-320331-wtxja5i9	194	6	and	and	CC
cord-320331-wtxja5i9	194	7	meta	meta	NNP
cord-320331-wtxja5i9	194	8	-	-	HYPH
cord-320331-wtxja5i9	194	9	analysis	analysis	NN
cord-320331-wtxja5i9	194	10	was	be	VBD
cord-320331-wtxja5i9	194	11	not	not	RB
cord-320331-wtxja5i9	194	12	only	only	RB
cord-320331-wtxja5i9	194	13	limited	limit	VBN
cord-320331-wtxja5i9	194	14	to	to	IN
cord-320331-wtxja5i9	194	15	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	194	16	(	(	-LRB-
cord-320331-wtxja5i9	194	17	2	2	CD
cord-320331-wtxja5i9	194	18	studies	study	NNS
cord-320331-wtxja5i9	194	19	)	)	-RRB-
cord-320331-wtxja5i9	194	20	,	,	,
cord-320331-wtxja5i9	194	21	but	but	CC
cord-320331-wtxja5i9	194	22	included	include	VBD
cord-320331-wtxja5i9	194	23	other	other	JJ
cord-320331-wtxja5i9	194	24	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	194	25	infections	infection	NNS
cord-320331-wtxja5i9	194	26	such	such	JJ
cord-320331-wtxja5i9	194	27	as	as	IN
cord-320331-wtxja5i9	194	28	those	those	DT
cord-320331-wtxja5i9	194	29	caused	cause	VBN
cord-320331-wtxja5i9	194	30	by	by	IN
cord-320331-wtxja5i9	194	31	SARS	SARS	NNP
cord-320331-wtxja5i9	194	32	-	-	HYPH
cord-320331-wtxja5i9	194	33	CoV	CoV	NNP
cord-320331-wtxja5i9	194	34	(	(	-LRB-
cord-320331-wtxja5i9	194	35	11	11	CD
cord-320331-wtxja5i9	194	36	studies	study	NNS
cord-320331-wtxja5i9	194	37	)	)	-RRB-
cord-320331-wtxja5i9	194	38	and	and	CC
cord-320331-wtxja5i9	194	39	MERS	MERS	NNP
cord-320331-wtxja5i9	194	40	-	-	HYPH
cord-320331-wtxja5i9	194	41	CoV	CoV	NNP
cord-320331-wtxja5i9	194	42	(	(	-LRB-
cord-320331-wtxja5i9	194	43	2	2	CD
cord-320331-wtxja5i9	194	44	studies	study	NNS
cord-320331-wtxja5i9	194	45	)	)	-RRB-
cord-320331-wtxja5i9	194	46	,	,	,
cord-320331-wtxja5i9	194	47	which	which	WDT
cord-320331-wtxja5i9	194	48	may	may	MD
cord-320331-wtxja5i9	194	49	allow	allow	VB
cord-320331-wtxja5i9	194	50	for	for	IN
cord-320331-wtxja5i9	194	51	differences	difference	NNS
cord-320331-wtxja5i9	194	52	in	in	IN
cord-320331-wtxja5i9	194	53	the	the	DT
cord-320331-wtxja5i9	194	54	prognosis	prognosis	NN
cord-320331-wtxja5i9	194	55	and	and	CC
cord-320331-wtxja5i9	194	56	clinical	clinical	JJ
cord-320331-wtxja5i9	194	57	outcomes	outcome	NNS
cord-320331-wtxja5i9	194	58	of	of	IN
cord-320331-wtxja5i9	194	59	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	194	60	patients	patient	NNS
cord-320331-wtxja5i9	194	61	.	.	.
cord-320331-wtxja5i9	195	1	Another	another	DT
cord-320331-wtxja5i9	195	2	systematic	systematic	JJ
cord-320331-wtxja5i9	195	3	review	review	NN
cord-320331-wtxja5i9	195	4	and	and	CC
cord-320331-wtxja5i9	195	5	meta	meta	NNP
cord-320331-wtxja5i9	195	6	-	-	HYPH
cord-320331-wtxja5i9	195	7	analysis	analysis	NN
cord-320331-wtxja5i9	195	8	of	of	IN
cord-320331-wtxja5i9	195	9	11	11	CD
cord-320331-wtxja5i9	195	10	studies	study	NNS
cord-320331-wtxja5i9	195	11	on	on	IN
cord-320331-wtxja5i9	195	12	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	195	13	use	use	NN
cord-320331-wtxja5i9	195	14	in	in	IN
cord-320331-wtxja5i9	195	15	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	195	16	infections	infection	NNS
cord-320331-wtxja5i9	195	17	showed	show	VBD
cord-320331-wtxja5i9	195	18	a	a	DT
cord-320331-wtxja5i9	195	19	statistically	statistically	RB
cord-320331-wtxja5i9	195	20	significant	significant	JJ
cord-320331-wtxja5i9	195	21	delay	delay	NN
cord-320331-wtxja5i9	195	22	in	in	IN
cord-320331-wtxja5i9	195	23	virus	virus	NN
cord-320331-wtxja5i9	195	24	clearing	clearing	NN
cord-320331-wtxja5i9	195	25	of	of	IN
cord-320331-wtxja5i9	195	26	3.78	3.78	CD
cord-320331-wtxja5i9	195	27	days	day	NNS
cord-320331-wtxja5i9	195	28	(	(	-LRB-
cord-320331-wtxja5i9	195	29	CI	CI	NNP
cord-320331-wtxja5i9	195	30	1.16	1.16	CD
cord-320331-wtxja5i9	195	31	-	-	HYPH
cord-320331-wtxja5i9	195	32	6.41	6.41	CD
cord-320331-wtxja5i9	195	33	)	)	-RRB-
cord-320331-wtxja5i9	195	34	,	,	,
cord-320331-wtxja5i9	195	35	but	but	CC
cord-320331-wtxja5i9	195	36	with	with	IN
cord-320331-wtxja5i9	195	37	no	no	DT
cord-320331-wtxja5i9	195	38	significant	significant	JJ
cord-320331-wtxja5i9	195	39	changes	change	NNS
cord-320331-wtxja5i9	195	40	in	in	IN
cord-320331-wtxja5i9	195	41	hospitalization	hospitalization	NN
cord-320331-wtxja5i9	195	42	duration	duration	NN
cord-320331-wtxja5i9	195	43	,	,	,
cord-320331-wtxja5i9	195	44	use	use	NN
cord-320331-wtxja5i9	195	45	of	of	IN
cord-320331-wtxja5i9	195	46	mechanical	mechanical	JJ
cord-320331-wtxja5i9	195	47	ventilation	ventilation	NN
cord-320331-wtxja5i9	195	48	,	,	,
cord-320331-wtxja5i9	195	49	or	or	CC
cord-320331-wtxja5i9	195	50	survival	survival	NN
cord-320331-wtxja5i9	195	51	[	[	-LRB-
cord-320331-wtxja5i9	195	52	106	106	CD
cord-320331-wtxja5i9	195	53	]	]	-RRB-
cord-320331-wtxja5i9	195	54	.	.	.
cord-320331-wtxja5i9	196	1	In	in	IN
cord-320331-wtxja5i9	196	2	these	these	DT
cord-320331-wtxja5i9	196	3	two	two	CD
cord-320331-wtxja5i9	196	4	studies	study	NNS
cord-320331-wtxja5i9	196	5	,	,	,
cord-320331-wtxja5i9	196	6	the	the	DT
cord-320331-wtxja5i9	196	7	results	result	NNS
cord-320331-wtxja5i9	196	8	may	may	MD
cord-320331-wtxja5i9	196	9	have	have	VB
cord-320331-wtxja5i9	196	10	differed	differ	VBN
cord-320331-wtxja5i9	196	11	mainly	mainly	RB
cord-320331-wtxja5i9	196	12	because	because	IN
cord-320331-wtxja5i9	196	13	the	the	DT
cord-320331-wtxja5i9	196	14	included	include	VBN
cord-320331-wtxja5i9	196	15	studies	study	NNS
cord-320331-wtxja5i9	196	16	were	be	VBD
cord-320331-wtxja5i9	196	17	mostly	mostly	RB
cord-320331-wtxja5i9	196	18	retrospective	retrospective	JJ
cord-320331-wtxja5i9	196	19	in	in	IN
cord-320331-wtxja5i9	196	20	nature	nature	NN
cord-320331-wtxja5i9	196	21	.	.	.
cord-320331-wtxja5i9	197	1	Hence	hence	RB
cord-320331-wtxja5i9	197	2	,	,	,
cord-320331-wtxja5i9	197	3	baseline	baseline	JJ
cord-320331-wtxja5i9	197	4	characteristics	characteristic	NNS
cord-320331-wtxja5i9	197	5	and	and	CC
cord-320331-wtxja5i9	197	6	management	management	NN
cord-320331-wtxja5i9	197	7	may	may	MD
cord-320331-wtxja5i9	197	8	not	not	RB
cord-320331-wtxja5i9	197	9	have	have	VB
cord-320331-wtxja5i9	197	10	been	be	VBN
cord-320331-wtxja5i9	197	11	the	the	DT
cord-320331-wtxja5i9	197	12	same	same	JJ
cord-320331-wtxja5i9	197	13	within	within	IN
cord-320331-wtxja5i9	197	14	a	a	DT
cord-320331-wtxja5i9	197	15	singular	singular	JJ
cord-320331-wtxja5i9	197	16	study	study	NN
cord-320331-wtxja5i9	197	17	,	,	,
cord-320331-wtxja5i9	197	18	and	and	CC
cord-320331-wtxja5i9	197	19	this	this	DT
cord-320331-wtxja5i9	197	20	may	may	MD
cord-320331-wtxja5i9	197	21	have	have	VB
cord-320331-wtxja5i9	197	22	affected	affect	VBN
cord-320331-wtxja5i9	197	23	the	the	DT
cord-320331-wtxja5i9	197	24	Recommendations	Recommendations	NNPS
cord-320331-wtxja5i9	197	25	Assessment	Assessment	NNP
cord-320331-wtxja5i9	197	26	,	,	,
cord-320331-wtxja5i9	197	27	Development	Development	NNP
cord-320331-wtxja5i9	197	28	,	,	,
cord-320331-wtxja5i9	197	29	and	and	CC
cord-320331-wtxja5i9	197	30	Evaluation	Evaluation	NNP
cord-320331-wtxja5i9	197	31	)	)	-RRB-
cord-320331-wtxja5i9	197	32	approach	approach	NN
cord-320331-wtxja5i9	197	33	,	,	,
cord-320331-wtxja5i9	197	34	which	which	WDT
cord-320331-wtxja5i9	197	35	was	be	VBD
cord-320331-wtxja5i9	197	36	mainly	mainly	RB
cord-320331-wtxja5i9	197	37	due	due	JJ
cord-320331-wtxja5i9	197	38	to	to	IN
cord-320331-wtxja5i9	197	39	the	the	DT
cord-320331-wtxja5i9	197	40	nature	nature	NN
cord-320331-wtxja5i9	197	41	of	of	IN
cord-320331-wtxja5i9	197	42	the	the	DT
cord-320331-wtxja5i9	197	43	studies	study	NNS
cord-320331-wtxja5i9	197	44	included	include	VBD
cord-320331-wtxja5i9	197	45	(	(	-LRB-
cord-320331-wtxja5i9	197	46	mostly	mostly	RB
cord-320331-wtxja5i9	197	47	retrospective	retrospective	JJ
cord-320331-wtxja5i9	197	48	cohort	cohort	NN
cord-320331-wtxja5i9	197	49	studies	study	NNS
cord-320331-wtxja5i9	197	50	)	)	-RRB-
cord-320331-wtxja5i9	197	51	.	.	.
cord-320331-wtxja5i9	198	1	In	in	IN
cord-320331-wtxja5i9	198	2	addition	addition	NN
cord-320331-wtxja5i9	198	3	,	,	,
cord-320331-wtxja5i9	198	4	the	the	DT
cord-320331-wtxja5i9	198	5	inclusion	inclusion	NN
cord-320331-wtxja5i9	198	6	of	of	IN
cord-320331-wtxja5i9	198	7	outcomes	outcome	NNS
cord-320331-wtxja5i9	198	8	from	from	IN
cord-320331-wtxja5i9	198	9	non	non	JJ
cord-320331-wtxja5i9	198	10	-	-	JJ
cord-320331-wtxja5i9	198	11	coronavirus	coronavirus	JJ
cord-320331-wtxja5i9	198	12	infections	infection	NNS
cord-320331-wtxja5i9	198	13	may	may	MD
cord-320331-wtxja5i9	198	14	have	have	VB
cord-320331-wtxja5i9	198	15	significantly	significantly	RB
cord-320331-wtxja5i9	198	16	confounded	confound	VBN
cord-320331-wtxja5i9	198	17	and	and	CC
cord-320331-wtxja5i9	198	18	affected	affect	VBD
cord-320331-wtxja5i9	198	19	the	the	DT
cord-320331-wtxja5i9	198	20	analysis	analysis	NN
cord-320331-wtxja5i9	198	21	of	of	IN
cord-320331-wtxja5i9	198	22	outcomes	outcome	NNS
cord-320331-wtxja5i9	198	23	.	.	.
cord-320331-wtxja5i9	199	1	On	on	IN
cord-320331-wtxja5i9	199	2	the	the	DT
cord-320331-wtxja5i9	199	3	other	other	JJ
cord-320331-wtxja5i9	199	4	hand	hand	NN
cord-320331-wtxja5i9	199	5	,	,	,
cord-320331-wtxja5i9	199	6	a	a	DT
cord-320331-wtxja5i9	199	7	systematic	systematic	JJ
cord-320331-wtxja5i9	199	8	review	review	NN
cord-320331-wtxja5i9	199	9	showed	show	VBD
cord-320331-wtxja5i9	199	10	that	that	IN
cord-320331-wtxja5i9	199	11	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	199	12	may	may	MD
cord-320331-wtxja5i9	199	13	help	help	VB
cord-320331-wtxja5i9	199	14	reduce	reduce	VB
cord-320331-wtxja5i9	199	15	immunopathological	immunopathological	JJ
cord-320331-wtxja5i9	199	16	damage	damage	NN
cord-320331-wtxja5i9	199	17	and	and	CC
cord-320331-wtxja5i9	199	18	may	may	MD
cord-320331-wtxja5i9	199	19	improve	improve	VB
cord-320331-wtxja5i9	199	20	outcomes	outcome	NNS
cord-320331-wtxja5i9	199	21	when	when	WRB
cord-320331-wtxja5i9	199	22	given	give	VBN
cord-320331-wtxja5i9	199	23	high	high	JJ
cord-320331-wtxja5i9	199	24	-	-	HYPH
cord-320331-wtxja5i9	199	25	dose	dose	NN
cord-320331-wtxja5i9	199	26	with	with	IN
cord-320331-wtxja5i9	199	27	a	a	DT
cord-320331-wtxja5i9	199	28	quinolone	quinolone	NN
cord-320331-wtxja5i9	199	29	early	early	RB
cord-320331-wtxja5i9	199	30	in	in	IN
cord-320331-wtxja5i9	199	31	the	the	DT
cord-320331-wtxja5i9	199	32	infection	infection	NN
cord-320331-wtxja5i9	199	33	,	,	,
cord-320331-wtxja5i9	199	34	but	but	CC
cord-320331-wtxja5i9	199	35	these	these	DT
cord-320331-wtxja5i9	199	36	results	result	NNS
cord-320331-wtxja5i9	199	37	were	be	VBD
cord-320331-wtxja5i9	199	38	specific	specific	JJ
cord-320331-wtxja5i9	199	39	for	for	IN
cord-320331-wtxja5i9	199	40	SARS	SARS	NNP
cord-320331-wtxja5i9	199	41	-	-	HYPH
cord-320331-wtxja5i9	199	42	CoV	CoV	NNP
cord-320331-wtxja5i9	199	43	and	and	CC
cord-320331-wtxja5i9	199	44	not	not	RB
cord-320331-wtxja5i9	199	45	for	for	IN
cord-320331-wtxja5i9	199	46	SARS	SARS	NNP
cord-320331-wtxja5i9	199	47	-	-	HYPH
cord-320331-wtxja5i9	199	48	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	199	49	[	[	-LRB-
cord-320331-wtxja5i9	199	50	103	103	CD
cord-320331-wtxja5i9	199	51	]	]	-RRB-
cord-320331-wtxja5i9	199	52	.	.	.
cord-320331-wtxja5i9	200	1	To	to	TO
cord-320331-wtxja5i9	200	2	resolve	resolve	VB
cord-320331-wtxja5i9	200	3	the	the	DT
cord-320331-wtxja5i9	200	4	contradicting	contradict	VBG
cord-320331-wtxja5i9	200	5	reports	report	NNS
cord-320331-wtxja5i9	200	6	,	,	,
cord-320331-wtxja5i9	200	7	randomized	randomize	VBN
cord-320331-wtxja5i9	200	8	controlled	control	VBN
cord-320331-wtxja5i9	200	9	trials	trial	NNS
cord-320331-wtxja5i9	200	10	of	of	IN
cord-320331-wtxja5i9	200	11	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	200	12	use	use	NN
cord-320331-wtxja5i9	200	13	and	and	CC
cord-320331-wtxja5i9	200	14	its	-PRON-	PRP$
cord-320331-wtxja5i9	200	15	benefits	benefit	NNS
cord-320331-wtxja5i9	200	16	or	or	CC
cord-320331-wtxja5i9	200	17	risks	risk	NNS
cord-320331-wtxja5i9	200	18	to	to	IN
cord-320331-wtxja5i9	200	19	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	200	20	outcomes	outcome	NNS
cord-320331-wtxja5i9	200	21	are	be	VBP
cord-320331-wtxja5i9	200	22	needed	need	VBN
cord-320331-wtxja5i9	200	23	,	,	,
cord-320331-wtxja5i9	200	24	especially	especially	RB
cord-320331-wtxja5i9	200	25	if	if	IN
cord-320331-wtxja5i9	200	26	more	more	RBR
cord-320331-wtxja5i9	200	27	accurate	accurate	JJ
cord-320331-wtxja5i9	200	28	results	result	NNS
cord-320331-wtxja5i9	200	29	are	be	VBP
cord-320331-wtxja5i9	200	30	to	to	TO
cord-320331-wtxja5i9	200	31	be	be	VB
cord-320331-wtxja5i9	200	32	generated	generate	VBN
cord-320331-wtxja5i9	200	33	.	.	.
cord-320331-wtxja5i9	201	1	To	to	IN
cord-320331-wtxja5i9	201	2	date	date	NN
cord-320331-wtxja5i9	201	3	,	,	,
cord-320331-wtxja5i9	201	4	there	there	EX
cord-320331-wtxja5i9	201	5	seems	seem	VBZ
cord-320331-wtxja5i9	201	6	to	to	TO
cord-320331-wtxja5i9	201	7	be	be	VB
cord-320331-wtxja5i9	201	8	emerging	emerge	VBG
cord-320331-wtxja5i9	201	9	clinical	clinical	JJ
cord-320331-wtxja5i9	201	10	evidence	evidence	NN
cord-320331-wtxja5i9	201	11	that	that	IN
cord-320331-wtxja5i9	201	12	caution	caution	NN
cord-320331-wtxja5i9	201	13	must	must	MD
cord-320331-wtxja5i9	201	14	be	be	VB
cord-320331-wtxja5i9	201	15	exercised	exercise	VBN
cord-320331-wtxja5i9	201	16	in	in	IN
cord-320331-wtxja5i9	201	17	the	the	DT
cord-320331-wtxja5i9	201	18	use	use	NN
cord-320331-wtxja5i9	201	19	of	of	IN
cord-320331-wtxja5i9	201	20	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	201	21	for	for	IN
cord-320331-wtxja5i9	201	22	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	201	23	-	-	HYPH
cord-320331-wtxja5i9	201	24	infected	infect	VBN
cord-320331-wtxja5i9	201	25	patients	patient	NNS
cord-320331-wtxja5i9	201	26	.	.	.
cord-320331-wtxja5i9	202	1	However	however	RB
cord-320331-wtxja5i9	202	2	,	,	,
cord-320331-wtxja5i9	202	3	due	due	IN
cord-320331-wtxja5i9	202	4	to	to	IN
cord-320331-wtxja5i9	202	5	the	the	DT
cord-320331-wtxja5i9	202	6	varying	varying	NN
cord-320331-wtxja5i9	202	7	and	and	CC
cord-320331-wtxja5i9	202	8	conflicting	conflicting	JJ
cord-320331-wtxja5i9	202	9	results	result	NNS
cord-320331-wtxja5i9	202	10	of	of	IN
cord-320331-wtxja5i9	202	11	their	-PRON-	PRP$
cord-320331-wtxja5i9	202	12	effects	effect	NNS
cord-320331-wtxja5i9	202	13	on	on	IN
cord-320331-wtxja5i9	202	14	clinical	clinical	JJ
cord-320331-wtxja5i9	202	15	outcome	outcome	NN
cord-320331-wtxja5i9	202	16	,	,	,
cord-320331-wtxja5i9	202	17	more	more	RBR
cord-320331-wtxja5i9	202	18	specific	specific	JJ
cord-320331-wtxja5i9	202	19	and	and	CC
cord-320331-wtxja5i9	202	20	better	well	RBR
cord-320331-wtxja5i9	202	21	designed	design	VBN
cord-320331-wtxja5i9	202	22	studies	study	NNS
cord-320331-wtxja5i9	202	23	are	be	VBP
cord-320331-wtxja5i9	202	24	required	require	VBN
cord-320331-wtxja5i9	202	25	for	for	IN
cord-320331-wtxja5i9	202	26	a	a	DT
cord-320331-wtxja5i9	202	27	better	well	JJR
cord-320331-wtxja5i9	202	28	evaluation	evaluation	NN
cord-320331-wtxja5i9	202	29	of	of	IN
cord-320331-wtxja5i9	202	30	current	current	JJ
cord-320331-wtxja5i9	202	31	recommendations	recommendation	NNS
cord-320331-wtxja5i9	202	32	.	.	.
cord-320331-wtxja5i9	203	1	Notwithstanding	notwithstanding	IN
cord-320331-wtxja5i9	203	2	,	,	,
cord-320331-wtxja5i9	203	3	the	the	DT
cord-320331-wtxja5i9	203	4	observed	observed	JJ
cord-320331-wtxja5i9	203	5	risks	risk	NNS
cord-320331-wtxja5i9	203	6	are	be	VBP
cord-320331-wtxja5i9	203	7	supported	support	VBN
cord-320331-wtxja5i9	203	8	experimentally	experimentally	RB
cord-320331-wtxja5i9	203	9	and	and	CC
cord-320331-wtxja5i9	203	10	pharmacologically	pharmacologically	RB
cord-320331-wtxja5i9	203	11	as	as	IN
cord-320331-wtxja5i9	203	12	will	will	MD
cord-320331-wtxja5i9	203	13	be	be	VB
cord-320331-wtxja5i9	203	14	discussed	discuss	VBN
cord-320331-wtxja5i9	203	15	.	.	.
cord-320331-wtxja5i9	204	1	First	first	RB
cord-320331-wtxja5i9	204	2	,	,	,
cord-320331-wtxja5i9	204	3	note	note	VB
cord-320331-wtxja5i9	204	4	that	that	IN
cord-320331-wtxja5i9	204	5	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	204	6	are	be	VBP
cord-320331-wtxja5i9	204	7	divided	divide	VBN
cord-320331-wtxja5i9	204	8	into	into	IN
cord-320331-wtxja5i9	204	9	the	the	DT
cord-320331-wtxja5i9	204	10	mineralocorticoids	mineralocorticoid	NNS
cord-320331-wtxja5i9	204	11	and	and	CC
cord-320331-wtxja5i9	204	12	the	the	DT
cord-320331-wtxja5i9	204	13	J	J	NNP
cord-320331-wtxja5i9	204	14	o	o	NN
cord-320331-wtxja5i9	204	15	u	u	NN
cord-320331-wtxja5i9	204	16	r	r	NN
cord-320331-wtxja5i9	204	17	n	n	NN
cord-320331-wtxja5i9	204	18	a	a	DT
cord-320331-wtxja5i9	204	19	l	l	NN
cord-320331-wtxja5i9	204	20	P	p	NN
cord-320331-wtxja5i9	204	21	r	r	NN
cord-320331-wtxja5i9	204	22	e	e	NN
cord-320331-wtxja5i9	204	23	-p	-p	NN
cord-320331-wtxja5i9	205	1	r	r	LS
cord-320331-wtxja5i9	206	1	o	o	UH
cord-320331-wtxja5i9	206	2	o	o	NN
cord-320331-wtxja5i9	206	3	f	f	CD
cord-320331-wtxja5i9	206	4	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	206	5	.	.	.
cord-320331-wtxja5i9	207	1	Mineralocorticoids	mineralocorticoid	NNS
cord-320331-wtxja5i9	207	2	comprise	comprise	VBP
cord-320331-wtxja5i9	207	3	a	a	DT
cord-320331-wtxja5i9	207	4	group	group	NN
cord-320331-wtxja5i9	207	5	of	of	IN
cord-320331-wtxja5i9	207	6	proinflammatory	proinflammatory	JJ
cord-320331-wtxja5i9	207	7	hormones	hormone	NNS
cord-320331-wtxja5i9	207	8	that	that	WDT
cord-320331-wtxja5i9	207	9	primarily	primarily	RB
cord-320331-wtxja5i9	207	10	act	act	VBP
cord-320331-wtxja5i9	207	11	on	on	IN
cord-320331-wtxja5i9	207	12	the	the	DT
cord-320331-wtxja5i9	207	13	kidney	kidney	NN
cord-320331-wtxja5i9	207	14	to	to	TO
cord-320331-wtxja5i9	207	15	modulate	modulate	VB
cord-320331-wtxja5i9	207	16	renal	renal	JJ
cord-320331-wtxja5i9	207	17	-	-	HYPH
cord-320331-wtxja5i9	207	18	sodium	sodium	NN
cord-320331-wtxja5i9	207	19	balance	balance	NN
cord-320331-wtxja5i9	207	20	and	and	CC
cord-320331-wtxja5i9	207	21	blood	blood	NN
cord-320331-wtxja5i9	207	22	pressure	pressure	NN
cord-320331-wtxja5i9	207	23	by	by	IN
cord-320331-wtxja5i9	207	24	activating	activate	VBG
cord-320331-wtxja5i9	207	25	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	207	26	receptors	receptor	NNS
cord-320331-wtxja5i9	207	27	(	(	-LRB-
cord-320331-wtxja5i9	207	28	MR	MR	NNP
cord-320331-wtxja5i9	207	29	)	)	-RRB-
cord-320331-wtxja5i9	208	1	[	[	-LRB-
cord-320331-wtxja5i9	208	2	46	46	CD
cord-320331-wtxja5i9	208	3	]	]	-RRB-
cord-320331-wtxja5i9	209	1	(	(	-LRB-
cord-320331-wtxja5i9	209	2	Fig	Fig	NNP
cord-320331-wtxja5i9	209	3	.	.	.
cord-320331-wtxja5i9	209	4	3	3	CD
cord-320331-wtxja5i9	209	5	)	)	-RRB-
cord-320331-wtxja5i9	209	6	.	.	.
cord-320331-wtxja5i9	210	1	It	-PRON-	PRP
cord-320331-wtxja5i9	210	2	is	be	VBZ
cord-320331-wtxja5i9	210	3	thought	think	VBN
cord-320331-wtxja5i9	210	4	to	to	TO
cord-320331-wtxja5i9	210	5	be	be	VB
cord-320331-wtxja5i9	210	6	proinflammatory	proinflammatory	JJ
cord-320331-wtxja5i9	210	7	,	,	,
cord-320331-wtxja5i9	210	8	acting	act	VBG
cord-320331-wtxja5i9	210	9	through	through	IN
cord-320331-wtxja5i9	210	10	the	the	DT
cord-320331-wtxja5i9	210	11	upregulation	upregulation	NN
cord-320331-wtxja5i9	210	12	of	of	IN
cord-320331-wtxja5i9	210	13	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	210	14	cytokines	cytokine	NNS
cord-320331-wtxja5i9	210	15	to	to	TO
cord-320331-wtxja5i9	210	16	influence	influence	VB
cord-320331-wtxja5i9	210	17	T	T	NNP
cord-320331-wtxja5i9	210	18	and	and	CC
cord-320331-wtxja5i9	210	19	B	b	NN
cord-320331-wtxja5i9	210	20	lymphocytes	lymphocyte	NNS
cord-320331-wtxja5i9	210	21	,	,	,
cord-320331-wtxja5i9	210	22	monocytes	monocyte	NNS
cord-320331-wtxja5i9	210	23	,	,	,
cord-320331-wtxja5i9	210	24	neutrophils	neutrophil	NNS
cord-320331-wtxja5i9	210	25	,	,	,
cord-320331-wtxja5i9	210	26	and	and	CC
cord-320331-wtxja5i9	210	27	dendritic	dendritic	JJ
cord-320331-wtxja5i9	210	28	cells	cell	NNS
cord-320331-wtxja5i9	210	29	to	to	TO
cord-320331-wtxja5i9	210	30	mount	mount	VB
cord-320331-wtxja5i9	210	31	an	an	DT
cord-320331-wtxja5i9	210	32	immune	immune	JJ
cord-320331-wtxja5i9	210	33	response	response	NN
cord-320331-wtxja5i9	210	34	.	.	.
cord-320331-wtxja5i9	211	1	This	this	DT
cord-320331-wtxja5i9	211	2	interaction	interaction	NN
cord-320331-wtxja5i9	211	3	subsequently	subsequently	RB
cord-320331-wtxja5i9	211	4	promotes	promote	VBZ
cord-320331-wtxja5i9	211	5	inflammation	inflammation	NN
cord-320331-wtxja5i9	211	6	and	and	CC
cord-320331-wtxja5i9	211	7	increased	increase	VBN
cord-320331-wtxja5i9	211	8	levels	level	NNS
cord-320331-wtxja5i9	211	9	of	of	IN
cord-320331-wtxja5i9	211	10	reactive	reactive	JJ
cord-320331-wtxja5i9	211	11	oxygen	oxygen	NN
cord-320331-wtxja5i9	211	12	species	specie	NNS
cord-320331-wtxja5i9	211	13	(	(	-LRB-
cord-320331-wtxja5i9	211	14	ROS	ROS	NNP
cord-320331-wtxja5i9	211	15	)	)	-RRB-
cord-320331-wtxja5i9	211	16	following	follow	VBG
cord-320331-wtxja5i9	211	17	the	the	DT
cord-320331-wtxja5i9	211	18	activation	activation	NN
cord-320331-wtxja5i9	211	19	of	of	IN
cord-320331-wtxja5i9	211	20	hormonal	hormonal	JJ
cord-320331-wtxja5i9	211	21	response	response	NN
cord-320331-wtxja5i9	211	22	elements	element	NNS
cord-320331-wtxja5i9	211	23	(	(	-LRB-
cord-320331-wtxja5i9	211	24	HREs	HREs	NNP
cord-320331-wtxja5i9	211	25	)	)	-RRB-
cord-320331-wtxja5i9	211	26	inside	inside	IN
cord-320331-wtxja5i9	211	27	the	the	DT
cord-320331-wtxja5i9	211	28	nucleus	nucleus	NN
cord-320331-wtxja5i9	211	29	(	(	-LRB-
cord-320331-wtxja5i9	211	30	Fig	Fig	NNP
cord-320331-wtxja5i9	211	31	4	4	CD
cord-320331-wtxja5i9	211	32	)	)	-RRB-
cord-320331-wtxja5i9	212	1	[	[	-LRB-
cord-320331-wtxja5i9	212	2	47	47	CD
cord-320331-wtxja5i9	212	3	]	]	-RRB-
cord-320331-wtxja5i9	212	4	.	.	.
cord-320331-wtxja5i9	213	1	In	in	IN
cord-320331-wtxja5i9	213	2	pathological	pathological	JJ
cord-320331-wtxja5i9	213	3	conditions	condition	NNS
cord-320331-wtxja5i9	213	4	,	,	,
cord-320331-wtxja5i9	213	5	the	the	DT
cord-320331-wtxja5i9	213	6	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	213	7	receptors	receptor	NNS
cord-320331-wtxja5i9	213	8	(	(	-LRB-
cord-320331-wtxja5i9	213	9	MRs	MRs	NNP
cord-320331-wtxja5i9	213	10	)	)	-RRB-
cord-320331-wtxja5i9	213	11	can	can	MD
cord-320331-wtxja5i9	213	12	remain	remain	VB
cord-320331-wtxja5i9	213	13	activated	activate	VBN
cord-320331-wtxja5i9	213	14	regardless	regardless	RB
cord-320331-wtxja5i9	213	15	of	of	IN
cord-320331-wtxja5i9	213	16	Ang	Ang	NNP
cord-320331-wtxja5i9	213	17	II	II	NNP
cord-320331-wtxja5i9	213	18	levels	level	NNS
cord-320331-wtxja5i9	213	19	,	,	,
cord-320331-wtxja5i9	213	20	interfering	interfere	VBG
cord-320331-wtxja5i9	213	21	with	with	IN
cord-320331-wtxja5i9	213	22	normal	normal	JJ
cord-320331-wtxja5i9	213	23	salt	salt	NN
cord-320331-wtxja5i9	213	24	and	and	CC
cord-320331-wtxja5i9	213	25	water	water	NN
cord-320331-wtxja5i9	213	26	retention	retention	NN
cord-320331-wtxja5i9	213	27	and	and	CC
cord-320331-wtxja5i9	213	28	electrolyte	electrolyte	JJ
cord-320331-wtxja5i9	213	29	regulation	regulation	NN
cord-320331-wtxja5i9	213	30	.	.	.
cord-320331-wtxja5i9	214	1	This	this	DT
cord-320331-wtxja5i9	214	2	eventually	eventually	RB
cord-320331-wtxja5i9	214	3	leads	lead	VBZ
cord-320331-wtxja5i9	214	4	to	to	IN
cord-320331-wtxja5i9	214	5	the	the	DT
cord-320331-wtxja5i9	214	6	exacerbation	exacerbation	NN
cord-320331-wtxja5i9	214	7	of	of	IN
cord-320331-wtxja5i9	214	8	hypertension	hypertension	NN
cord-320331-wtxja5i9	214	9	,	,	,
cord-320331-wtxja5i9	214	10	which	which	WDT
cord-320331-wtxja5i9	214	11	if	if	IN
cord-320331-wtxja5i9	214	12	not	not	RB
cord-320331-wtxja5i9	214	13	promptly	promptly	RB
cord-320331-wtxja5i9	214	14	addressed	address	VBN
cord-320331-wtxja5i9	214	15	,	,	,
cord-320331-wtxja5i9	214	16	can	can	MD
cord-320331-wtxja5i9	214	17	lead	lead	VB
cord-320331-wtxja5i9	214	18	to	to	IN
cord-320331-wtxja5i9	214	19	progressive	progressive	JJ
cord-320331-wtxja5i9	214	20	organ	organ	NN
cord-320331-wtxja5i9	214	21	injury	injury	NN
cord-320331-wtxja5i9	214	22	and	and	CC
cord-320331-wtxja5i9	214	23	finally	finally	RB
cord-320331-wtxja5i9	214	24	organ	organ	NN
cord-320331-wtxja5i9	214	25	failure	failure	NN
cord-320331-wtxja5i9	214	26	.	.	.
cord-320331-wtxja5i9	215	1	Glucocorticoids	Glucocorticoids	NNP
cord-320331-wtxja5i9	215	2	on	on	IN
cord-320331-wtxja5i9	215	3	the	the	DT
cord-320331-wtxja5i9	215	4	other	other	JJ
cord-320331-wtxja5i9	215	5	hand	hand	NN
cord-320331-wtxja5i9	215	6	affect	affect	VBP
cord-320331-wtxja5i9	215	7	insulin	insulin	NN
cord-320331-wtxja5i9	215	8	metabolism	metabolism	NN
cord-320331-wtxja5i9	215	9	,	,	,
cord-320331-wtxja5i9	215	10	hepatic	hepatic	JJ
cord-320331-wtxja5i9	215	11	synthesis	synthesis	NN
cord-320331-wtxja5i9	215	12	,	,	,
cord-320331-wtxja5i9	215	13	and	and	CC
cord-320331-wtxja5i9	215	14	muscle	muscle	NN
cord-320331-wtxja5i9	215	15	protein	protein	NN
cord-320331-wtxja5i9	215	16	catabolism	catabolism	NN
cord-320331-wtxja5i9	215	17	by	by	IN
cord-320331-wtxja5i9	215	18	increasing	increase	VBG
cord-320331-wtxja5i9	215	19	amino	amino	NN
cord-320331-wtxja5i9	215	20	acid	acid	NN
cord-320331-wtxja5i9	215	21	production	production	NN
cord-320331-wtxja5i9	215	22	,	,	,
cord-320331-wtxja5i9	215	23	and	and	CC
cord-320331-wtxja5i9	215	24	increase	increase	VB
cord-320331-wtxja5i9	215	25	the	the	DT
cord-320331-wtxja5i9	215	26	availability	availability	NN
cord-320331-wtxja5i9	215	27	of	of	IN
cord-320331-wtxja5i9	215	28	glycogen	glycogen	NN
cord-320331-wtxja5i9	215	29	stores	store	NNS
cord-320331-wtxja5i9	215	30	to	to	TO
cord-320331-wtxja5i9	215	31	buffer	buffer	VB
cord-320331-wtxja5i9	215	32	blood	blood	NN
cord-320331-wtxja5i9	215	33	glucose	glucose	NN
cord-320331-wtxja5i9	215	34	concentration	concentration	NN
cord-320331-wtxja5i9	215	35	.	.	.
cord-320331-wtxja5i9	216	1	Insulin	insulin	NN
cord-320331-wtxja5i9	216	2	resistance	resistance	NN
cord-320331-wtxja5i9	216	3	triggers	trigger	VBZ
cord-320331-wtxja5i9	216	4	an	an	DT
cord-320331-wtxja5i9	216	5	increase	increase	NN
cord-320331-wtxja5i9	216	6	in	in	IN
cord-320331-wtxja5i9	216	7	blood	blood	NN
cord-320331-wtxja5i9	216	8	glucose	glucose	NN
cord-320331-wtxja5i9	216	9	,	,	,
cord-320331-wtxja5i9	216	10	which	which	WDT
cord-320331-wtxja5i9	216	11	causes	cause	VBZ
cord-320331-wtxja5i9	216	12	plasma	plasma	NN
cord-320331-wtxja5i9	216	13	volume	volume	NN
cord-320331-wtxja5i9	216	14	depletion	depletion	NN
cord-320331-wtxja5i9	216	15	secondary	secondary	JJ
cord-320331-wtxja5i9	216	16	to	to	IN
cord-320331-wtxja5i9	216	17	osmotic	osmotic	JJ
cord-320331-wtxja5i9	216	18	diuresis	diuresis	NN
cord-320331-wtxja5i9	216	19	(	(	-LRB-
cord-320331-wtxja5i9	216	20	Fig	Fig	NNP
cord-320331-wtxja5i9	216	21	.	.	.
cord-320331-wtxja5i9	216	22	3	3	CD
cord-320331-wtxja5i9	216	23	)	)	-RRB-
cord-320331-wtxja5i9	216	24	.	.	.
cord-320331-wtxja5i9	217	1	In	in	IN
cord-320331-wtxja5i9	217	2	response	response	NN
cord-320331-wtxja5i9	217	3	to	to	IN
cord-320331-wtxja5i9	217	4	resulting	result	VBG
cord-320331-wtxja5i9	217	5	plasma	plasma	NN
cord-320331-wtxja5i9	217	6	volume	volume	NN
cord-320331-wtxja5i9	217	7	reduction	reduction	NN
cord-320331-wtxja5i9	217	8	,	,	,
cord-320331-wtxja5i9	217	9	the	the	DT
cord-320331-wtxja5i9	217	10	juxtaglomerular	juxtaglomerular	JJ
cord-320331-wtxja5i9	217	11	cells	cell	NNS
cord-320331-wtxja5i9	217	12	of	of	IN
cord-320331-wtxja5i9	217	13	the	the	DT
cord-320331-wtxja5i9	217	14	kidneys	kidney	NNS
cord-320331-wtxja5i9	217	15	will	will	MD
cord-320331-wtxja5i9	217	16	produce	produce	VB
cord-320331-wtxja5i9	217	17	renin	renin	NN
cord-320331-wtxja5i9	217	18	to	to	TO
cord-320331-wtxja5i9	217	19	act	act	VB
cord-320331-wtxja5i9	217	20	upon	upon	IN
cord-320331-wtxja5i9	217	21	liver	liver	NN
cord-320331-wtxja5i9	217	22	angiotensinogen	angiotensinogen	NNP
cord-320331-wtxja5i9	217	23	to	to	TO
cord-320331-wtxja5i9	217	24	form	form	VB
cord-320331-wtxja5i9	217	25	Ang	Ang	NNP
cord-320331-wtxja5i9	217	26	I	I	NNP
cord-320331-wtxja5i9	217	27	,	,	,
cord-320331-wtxja5i9	217	28	followed	follow	VBN
cord-320331-wtxja5i9	217	29	by	by	IN
cord-320331-wtxja5i9	217	30	an	an	DT
cord-320331-wtxja5i9	217	31	ACE	ace	NN
cord-320331-wtxja5i9	217	32	-	-	HYPH
cord-320331-wtxja5i9	217	33	mediated	mediate	VBN
cord-320331-wtxja5i9	217	34	conversion	conversion	NN
cord-320331-wtxja5i9	217	35	to	to	IN
cord-320331-wtxja5i9	217	36	Ang	Ang	NNP
cord-320331-wtxja5i9	217	37	II	II	NNP
cord-320331-wtxja5i9	217	38	in	in	IN
cord-320331-wtxja5i9	217	39	an	an	DT
cord-320331-wtxja5i9	217	40	effort	effort	NN
cord-320331-wtxja5i9	217	41	to	to	TO
cord-320331-wtxja5i9	217	42	activate	activate	VB
cord-320331-wtxja5i9	217	43	the	the	DT
cord-320331-wtxja5i9	217	44	pathway	pathway	NN
cord-320331-wtxja5i9	217	45	called	call	VBN
cord-320331-wtxja5i9	217	46	the	the	DT
cord-320331-wtxja5i9	217	47	renin	renin	NN
cord-320331-wtxja5i9	217	48	-	-	HYPH
cord-320331-wtxja5i9	217	49	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	217	50	system	system	NN
cord-320331-wtxja5i9	217	51	to	to	TO
cord-320331-wtxja5i9	217	52	return	return	VB
cord-320331-wtxja5i9	217	53	plasma	plasma	NN
cord-320331-wtxja5i9	217	54	volume	volume	NN
cord-320331-wtxja5i9	217	55	back	back	RB
cord-320331-wtxja5i9	217	56	to	to	IN
cord-320331-wtxja5i9	217	57	normal	normal	JJ
cord-320331-wtxja5i9	217	58	.	.	.
cord-320331-wtxja5i9	218	1	Subsequently	subsequently	RB
cord-320331-wtxja5i9	218	2	,	,	,
cord-320331-wtxja5i9	218	3	ACE2	ACE2	NNP
cord-320331-wtxja5i9	218	4	can	can	MD
cord-320331-wtxja5i9	218	5	increase	increase	VB
cord-320331-wtxja5i9	218	6	proportionally	proportionally	RB
cord-320331-wtxja5i9	218	7	with	with	IN
cord-320331-wtxja5i9	218	8	Ang	Ang	NNP
cord-320331-wtxja5i9	218	9	II	II	NNP
cord-320331-wtxja5i9	218	10	,	,	,
cord-320331-wtxja5i9	218	11	acting	act	VBG
cord-320331-wtxja5i9	218	12	to	to	TO
cord-320331-wtxja5i9	218	13	produce	produce	VB
cord-320331-wtxja5i9	218	14	Ang	Ang	NNP
cord-320331-wtxja5i9	218	15	(	(	-LRB-
cord-320331-wtxja5i9	218	16	1	1	CD
cord-320331-wtxja5i9	218	17	-	-	SYM
cord-320331-wtxja5i9	218	18	7	7	CD
cord-320331-wtxja5i9	218	19	)	)	-RRB-
cord-320331-wtxja5i9	218	20	,	,	,
cord-320331-wtxja5i9	218	21	which	which	WDT
cord-320331-wtxja5i9	218	22	we	-PRON-	PRP
cord-320331-wtxja5i9	218	23	hypothesize	hypothesize	VBP
cord-320331-wtxja5i9	218	24	is	be	VBZ
cord-320331-wtxja5i9	218	25	the	the	DT
cord-320331-wtxja5i9	218	26	mechanism	mechanism	NN
cord-320331-wtxja5i9	218	27	for	for	IN
cord-320331-wtxja5i9	218	28	glucocorticoid	glucocorticoid	NN
cord-320331-wtxja5i9	218	29	-	-	HYPH
cord-320331-wtxja5i9	218	30	enhanced	enhance	VBN
cord-320331-wtxja5i9	218	31	SARS	SARS	NNP
cord-320331-wtxja5i9	218	32	-	-	HYPH
cord-320331-wtxja5i9	218	33	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	218	34	virulence	virulence	NN
cord-320331-wtxja5i9	218	35	(	(	-LRB-
cord-320331-wtxja5i9	218	36	Fig	fig	NN
cord-320331-wtxja5i9	218	37	.	.	.
cord-320331-wtxja5i9	218	38	3	3	CD
cord-320331-wtxja5i9	218	39	)	)	-RRB-
cord-320331-wtxja5i9	218	40	.	.	.
cord-320331-wtxja5i9	219	1	On	on	IN
cord-320331-wtxja5i9	219	2	the	the	DT
cord-320331-wtxja5i9	219	3	other	other	JJ
cord-320331-wtxja5i9	219	4	hand	hand	NN
cord-320331-wtxja5i9	219	5	,	,	,
cord-320331-wtxja5i9	219	6	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	219	7	suppress	suppress	VBP
cord-320331-wtxja5i9	219	8	inflammation	inflammation	NN
cord-320331-wtxja5i9	219	9	by	by	IN
cord-320331-wtxja5i9	219	10	binding	bind	VBG
cord-320331-wtxja5i9	219	11	to	to	IN
cord-320331-wtxja5i9	219	12	glucocorticoid	glucocorticoid	NN
cord-320331-wtxja5i9	219	13	response	response	NN
cord-320331-wtxja5i9	219	14	elements	element	NNS
cord-320331-wtxja5i9	219	15	(	(	-LRB-
cord-320331-wtxja5i9	219	16	GREs	GREs	NNP
cord-320331-wtxja5i9	219	17	)	)	-RRB-
cord-320331-wtxja5i9	219	18	inside	inside	IN
cord-320331-wtxja5i9	219	19	the	the	DT
cord-320331-wtxja5i9	219	20	nucleus	nucleus	NN
cord-320331-wtxja5i9	219	21	to	to	TO
cord-320331-wtxja5i9	219	22	interact	interact	VB
cord-320331-wtxja5i9	219	23	with	with	IN
cord-320331-wtxja5i9	219	24	genes	gene	NNS
cord-320331-wtxja5i9	219	25	and	and	CC
cord-320331-wtxja5i9	219	26	affect	affect	VB
cord-320331-wtxja5i9	219	27	gene	gene	NN
cord-320331-wtxja5i9	219	28	transcription	transcription	NN
cord-320331-wtxja5i9	219	29	in	in	IN
cord-320331-wtxja5i9	219	30	three	three	CD
cord-320331-wtxja5i9	219	31	basic	basic	JJ
cord-320331-wtxja5i9	219	32	ways	way	NNS
cord-320331-wtxja5i9	219	33	(	(	-LRB-
cord-320331-wtxja5i9	219	34	transactivation	transactivation	NNP
cord-320331-wtxja5i9	219	35	,	,	,
cord-320331-wtxja5i9	219	36	trans	trans	NN
cord-320331-wtxja5i9	219	37	-	-	NN
cord-320331-wtxja5i9	219	38	repression	repression	NN
cord-320331-wtxja5i9	219	39	,	,	,
cord-320331-wtxja5i9	219	40	and	and	CC
cord-320331-wtxja5i9	219	41	cis	cis	NN
cord-320331-wtxja5i9	219	42	-	-	HYPH
cord-320331-wtxja5i9	219	43	repression	repression	NN
cord-320331-wtxja5i9	219	44	)	)	-RRB-
cord-320331-wtxja5i9	219	45	to	to	TO
cord-320331-wtxja5i9	219	46	suppress	suppress	VB
cord-320331-wtxja5i9	219	47	inflammation	inflammation	NN
cord-320331-wtxja5i9	219	48	or	or	CC
cord-320331-wtxja5i9	219	49	to	to	TO
cord-320331-wtxja5i9	219	50	prevent	prevent	VB
cord-320331-wtxja5i9	219	51	an	an	DT
cord-320331-wtxja5i9	219	52	immune	immune	JJ
cord-320331-wtxja5i9	219	53	response	response	NN
cord-320331-wtxja5i9	219	54	from	from	IN
cord-320331-wtxja5i9	219	55	occurring	occur	VBG
cord-320331-wtxja5i9	219	56	altogether	altogether	RB
cord-320331-wtxja5i9	219	57	[	[	-LRB-
cord-320331-wtxja5i9	219	58	47	47	CD
cord-320331-wtxja5i9	219	59	]	]	-RRB-
cord-320331-wtxja5i9	220	1	(	(	-LRB-
cord-320331-wtxja5i9	220	2	Fig	Fig	NNP
cord-320331-wtxja5i9	220	3	.	.	NNP
cord-320331-wtxja5i9	220	4	4	4	CD
cord-320331-wtxja5i9	220	5	)	)	-RRB-
cord-320331-wtxja5i9	220	6	.	.	.
cord-320331-wtxja5i9	221	1	J	J	NNP
cord-320331-wtxja5i9	221	2	o	o	NN
cord-320331-wtxja5i9	221	3	u	u	NN
cord-320331-wtxja5i9	221	4	r	r	NN
cord-320331-wtxja5i9	221	5	n	n	NN
cord-320331-wtxja5i9	222	1	a	a	DT
cord-320331-wtxja5i9	222	2	l	l	NN
cord-320331-wtxja5i9	222	3	P	p	NN
cord-320331-wtxja5i9	222	4	r	r	NN
cord-320331-wtxja5i9	222	5	e	e	NN
cord-320331-wtxja5i9	222	6	-p	-p	NN
cord-320331-wtxja5i9	222	7	r	r	NN
cord-320331-wtxja5i9	222	8	o	o	NN
cord-320331-wtxja5i9	222	9	o	o	NN
cord-320331-wtxja5i9	222	10	f	f	NN
cord-320331-wtxja5i9	222	11	Recent	recent	JJ
cord-320331-wtxja5i9	222	12	guidelines	guideline	NNS
cord-320331-wtxja5i9	222	13	released	release	VBN
cord-320331-wtxja5i9	222	14	by	by	IN
cord-320331-wtxja5i9	222	15	the	the	DT
cord-320331-wtxja5i9	222	16	UK	UK	NNP
cord-320331-wtxja5i9	222	17	National	National	NNP
cord-320331-wtxja5i9	222	18	Health	Health	NNP
cord-320331-wtxja5i9	222	19	Service	Service	NNP
cord-320331-wtxja5i9	222	20	(	(	-LRB-
cord-320331-wtxja5i9	222	21	NHS	NHS	NNP
cord-320331-wtxja5i9	222	22	)	)	-RRB-
cord-320331-wtxja5i9	222	23	on	on	IN
cord-320331-wtxja5i9	222	24	the	the	DT
cord-320331-wtxja5i9	222	25	intake	intake	NN
cord-320331-wtxja5i9	222	26	of	of	IN
cord-320331-wtxja5i9	222	27	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	222	28	for	for	IN
cord-320331-wtxja5i9	222	29	mild	mild	JJ
cord-320331-wtxja5i9	222	30	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	222	31	symptoms	symptom	NNS
cord-320331-wtxja5i9	222	32	has	have	VBZ
cord-320331-wtxja5i9	222	33	drawn	draw	VBN
cord-320331-wtxja5i9	222	34	flak	flak	NN
cord-320331-wtxja5i9	222	35	from	from	IN
cord-320331-wtxja5i9	222	36	some	some	DT
cord-320331-wtxja5i9	222	37	health	health	NN
cord-320331-wtxja5i9	222	38	experts	expert	NNS
cord-320331-wtxja5i9	222	39	as	as	IN
cord-320331-wtxja5i9	222	40	it	-PRON-	PRP
cord-320331-wtxja5i9	222	41	may	may	MD
cord-320331-wtxja5i9	222	42	pose	pose	VB
cord-320331-wtxja5i9	222	43	risks	risk	NNS
cord-320331-wtxja5i9	222	44	on	on	IN
cord-320331-wtxja5i9	222	45	increased	increase	VBN
cord-320331-wtxja5i9	222	46	severity	severity	NN
cord-320331-wtxja5i9	222	47	[	[	-LRB-
cord-320331-wtxja5i9	222	48	48	48	CD
cord-320331-wtxja5i9	222	49	]	]	-RRB-
cord-320331-wtxja5i9	222	50	.	.	.
cord-320331-wtxja5i9	223	1	Reduction	reduction	NN
cord-320331-wtxja5i9	223	2	of	of	IN
cord-320331-wtxja5i9	223	3	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	223	4	levels	level	NNS
cord-320331-wtxja5i9	223	5	in	in	IN
cord-320331-wtxja5i9	223	6	the	the	DT
cord-320331-wtxja5i9	223	7	body	body	NN
cord-320331-wtxja5i9	223	8	,	,	,
cord-320331-wtxja5i9	223	9	which	which	WDT
cord-320331-wtxja5i9	223	10	is	be	VBZ
cord-320331-wtxja5i9	223	11	the	the	DT
cord-320331-wtxja5i9	223	12	main	main	JJ
cord-320331-wtxja5i9	223	13	action	action	NN
cord-320331-wtxja5i9	223	14	of	of	IN
cord-320331-wtxja5i9	223	15	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	223	16	like	like	IN
cord-320331-wtxja5i9	223	17	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	223	18	,	,	,
cord-320331-wtxja5i9	223	19	effectively	effectively	RB
cord-320331-wtxja5i9	223	20	reduces	reduce	VBZ
cord-320331-wtxja5i9	223	21	the	the	DT
cord-320331-wtxja5i9	223	22	immune	immune	JJ
cord-320331-wtxja5i9	223	23	response	response	NN
cord-320331-wtxja5i9	223	24	,	,	,
cord-320331-wtxja5i9	223	25	and	and	CC
cord-320331-wtxja5i9	223	26	previous	previous	JJ
cord-320331-wtxja5i9	223	27	reports	report	NNS
cord-320331-wtxja5i9	223	28	have	have	VBP
cord-320331-wtxja5i9	223	29	shown	show	VBN
cord-320331-wtxja5i9	223	30	no	no	DT
cord-320331-wtxja5i9	223	31	benefit	benefit	NN
cord-320331-wtxja5i9	223	32	of	of	IN
cord-320331-wtxja5i9	223	33	taking	take	VBG
cord-320331-wtxja5i9	223	34	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	223	35	in	in	IN
cord-320331-wtxja5i9	223	36	symptom	symptom	NN
cord-320331-wtxja5i9	223	37	control	control	NN
cord-320331-wtxja5i9	223	38	and	and	CC
cord-320331-wtxja5i9	223	39	clinical	clinical	JJ
cord-320331-wtxja5i9	223	40	outcome	outcome	NN
cord-320331-wtxja5i9	223	41	for	for	IN
cord-320331-wtxja5i9	223	42	respiratory	respiratory	JJ
cord-320331-wtxja5i9	223	43	infections	infection	NNS
cord-320331-wtxja5i9	223	44	,	,	,
cord-320331-wtxja5i9	223	45	and	and	CC
cord-320331-wtxja5i9	223	46	have	have	VBP
cord-320331-wtxja5i9	223	47	been	be	VBN
cord-320331-wtxja5i9	223	48	shown	show	VBN
cord-320331-wtxja5i9	223	49	to	to	TO
cord-320331-wtxja5i9	223	50	worsen	worsen	VB
cord-320331-wtxja5i9	223	51	the	the	DT
cord-320331-wtxja5i9	223	52	prognosis	prognosis	NN
cord-320331-wtxja5i9	223	53	of	of	IN
cord-320331-wtxja5i9	223	54	community	community	NN
cord-320331-wtxja5i9	223	55	-	-	HYPH
cord-320331-wtxja5i9	223	56	acquired	acquire	VBN
cord-320331-wtxja5i9	223	57	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	223	58	[	[	-LRB-
cord-320331-wtxja5i9	223	59	49	49	CD
cord-320331-wtxja5i9	223	60	,	,	,
cord-320331-wtxja5i9	223	61	50	50	CD
cord-320331-wtxja5i9	223	62	]	]	-RRB-
cord-320331-wtxja5i9	223	63	.	.	.
cord-320331-wtxja5i9	224	1	In	in	IN
cord-320331-wtxja5i9	224	2	a	a	DT
cord-320331-wtxja5i9	224	3	randomized	randomized	JJ
cord-320331-wtxja5i9	224	4	,	,	,
cord-320331-wtxja5i9	224	5	placebo	placebo	NN
cord-320331-wtxja5i9	224	6	-	-	HYPH
cord-320331-wtxja5i9	224	7	controlled	control	VBN
cord-320331-wtxja5i9	224	8	study	study	NN
cord-320331-wtxja5i9	224	9	for	for	IN
cord-320331-wtxja5i9	224	10	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	224	11	use	use	NN
cord-320331-wtxja5i9	224	12	in	in	IN
cord-320331-wtxja5i9	224	13	managing	manage	VBG
cord-320331-wtxja5i9	224	14	respiratory	respiratory	JJ
cord-320331-wtxja5i9	224	15	syncytial	syncytial	JJ
cord-320331-wtxja5i9	224	16	virus	virus	NN
cord-320331-wtxja5i9	224	17	(	(	-LRB-
cord-320331-wtxja5i9	224	18	RSV	RSV	NNP
cord-320331-wtxja5i9	224	19	)	)	-RRB-
cord-320331-wtxja5i9	224	20	infection	infection	NN
cord-320331-wtxja5i9	224	21	,	,	,
cord-320331-wtxja5i9	224	22	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	224	23	was	be	VBD
cord-320331-wtxja5i9	224	24	not	not	RB
cord-320331-wtxja5i9	224	25	able	able	JJ
cord-320331-wtxja5i9	224	26	to	to	TO
cord-320331-wtxja5i9	224	27	prevent	prevent	VB
cord-320331-wtxja5i9	224	28	lung	lung	NN
cord-320331-wtxja5i9	224	29	consolidation	consolidation	NN
cord-320331-wtxja5i9	224	30	and	and	CC
cord-320331-wtxja5i9	224	31	was	be	VBD
cord-320331-wtxja5i9	224	32	shown	show	VBN
cord-320331-wtxja5i9	224	33	to	to	TO
cord-320331-wtxja5i9	224	34	increase	increase	VB
cord-320331-wtxja5i9	224	35	viral	viral	JJ
cord-320331-wtxja5i9	224	36	shedding	shed	VBG
cord-320331-wtxja5i9	224	37	[	[	-LRB-
cord-320331-wtxja5i9	224	38	51	51	CD
cord-320331-wtxja5i9	224	39	]	]	-RRB-
cord-320331-wtxja5i9	224	40	.	.	.
cord-320331-wtxja5i9	225	1	From	from	IN
cord-320331-wtxja5i9	225	2	these	these	DT
cord-320331-wtxja5i9	225	3	studies	study	NNS
cord-320331-wtxja5i9	225	4	,	,	,
cord-320331-wtxja5i9	225	5	we	-PRON-	PRP
cord-320331-wtxja5i9	225	6	can	can	MD
cord-320331-wtxja5i9	225	7	infer	infer	VB
cord-320331-wtxja5i9	225	8	the	the	DT
cord-320331-wtxja5i9	225	9	classical	classical	JJ
cord-320331-wtxja5i9	225	10	mechanism	mechanism	NN
cord-320331-wtxja5i9	225	11	by	by	IN
cord-320331-wtxja5i9	225	12	which	which	WDT
cord-320331-wtxja5i9	225	13	anti	anti	JJ
cord-320331-wtxja5i9	225	14	-	-	JJ
cord-320331-wtxja5i9	225	15	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	225	16	drugs	drug	NNS
cord-320331-wtxja5i9	225	17	aggravate	aggravate	VBP
cord-320331-wtxja5i9	225	18	infection	infection	NN
cord-320331-wtxja5i9	225	19	,	,	,
cord-320331-wtxja5i9	225	20	which	which	WDT
cord-320331-wtxja5i9	225	21	is	be	VBZ
cord-320331-wtxja5i9	225	22	to	to	TO
cord-320331-wtxja5i9	225	23	reduce	reduce	VB
cord-320331-wtxja5i9	225	24	the	the	DT
cord-320331-wtxja5i9	225	25	degree	degree	NN
cord-320331-wtxja5i9	225	26	of	of	IN
cord-320331-wtxja5i9	225	27	immune	immune	JJ
cord-320331-wtxja5i9	225	28	response	response	NN
cord-320331-wtxja5i9	225	29	that	that	IN
cord-320331-wtxja5i9	225	30	the	the	DT
cord-320331-wtxja5i9	225	31	body	body	NN
cord-320331-wtxja5i9	225	32	can	can	MD
cord-320331-wtxja5i9	225	33	mount	mount	VB
cord-320331-wtxja5i9	225	34	against	against	IN
cord-320331-wtxja5i9	225	35	a	a	DT
cord-320331-wtxja5i9	225	36	virus	virus	NN
cord-320331-wtxja5i9	225	37	and	and	CC
cord-320331-wtxja5i9	225	38	to	to	TO
cord-320331-wtxja5i9	225	39	allow	allow	VB
cord-320331-wtxja5i9	225	40	uncontrolled	uncontrolled	JJ
cord-320331-wtxja5i9	225	41	progression	progression	NN
cord-320331-wtxja5i9	225	42	.	.	.
cord-320331-wtxja5i9	226	1	When	when	WRB
cord-320331-wtxja5i9	226	2	a	a	DT
cord-320331-wtxja5i9	226	3	virus	virus	NN
cord-320331-wtxja5i9	226	4	infects	infect	VBZ
cord-320331-wtxja5i9	226	5	its	-PRON-	PRP$
cord-320331-wtxja5i9	226	6	host	host	NN
cord-320331-wtxja5i9	226	7	,	,	,
cord-320331-wtxja5i9	226	8	it	-PRON-	PRP
cord-320331-wtxja5i9	226	9	most	most	RBS
cord-320331-wtxja5i9	226	10	often	often	RB
cord-320331-wtxja5i9	226	11	remains	remain	VBZ
cord-320331-wtxja5i9	226	12	intracellular	intracellular	JJ
cord-320331-wtxja5i9	226	13	as	as	IN
cord-320331-wtxja5i9	226	14	viruses	virus	NNS
cord-320331-wtxja5i9	226	15	are	be	VBP
cord-320331-wtxja5i9	226	16	obligate	obligate	VBN
cord-320331-wtxja5i9	226	17	intracellular	intracellular	JJ
cord-320331-wtxja5i9	226	18	organisms	organism	NNS
cord-320331-wtxja5i9	226	19	,	,	,
cord-320331-wtxja5i9	226	20	and	and	CC
cord-320331-wtxja5i9	226	21	extracellular	extracellular	JJ
cord-320331-wtxja5i9	226	22	viruses	virus	NNS
cord-320331-wtxja5i9	226	23	are	be	VBP
cord-320331-wtxja5i9	226	24	most	most	RBS
cord-320331-wtxja5i9	226	25	likely	likely	RB
cord-320331-wtxja5i9	226	26	seen	see	VBN
cord-320331-wtxja5i9	226	27	only	only	RB
cord-320331-wtxja5i9	226	28	during	during	IN
cord-320331-wtxja5i9	226	29	the	the	DT
cord-320331-wtxja5i9	226	30	lytic	lytic	JJ
cord-320331-wtxja5i9	226	31	phase	phase	NN
cord-320331-wtxja5i9	226	32	.	.	.
cord-320331-wtxja5i9	227	1	When	when	WRB
cord-320331-wtxja5i9	227	2	viruses	virus	NNS
cord-320331-wtxja5i9	227	3	infect	infect	VBP
cord-320331-wtxja5i9	227	4	a	a	DT
cord-320331-wtxja5i9	227	5	cell	cell	NN
cord-320331-wtxja5i9	227	6	,	,	,
cord-320331-wtxja5i9	227	7	antigen	antigen	NN
cord-320331-wtxja5i9	227	8	-	-	HYPH
cord-320331-wtxja5i9	227	9	presenting	present	VBG
cord-320331-wtxja5i9	227	10	cells	cell	NNS
cord-320331-wtxja5i9	227	11	alert	alert	JJ
cord-320331-wtxja5i9	227	12	nearby	nearby	JJ
cord-320331-wtxja5i9	227	13	immune	immune	JJ
cord-320331-wtxja5i9	227	14	cells	cell	NNS
cord-320331-wtxja5i9	227	15	through	through	IN
cord-320331-wtxja5i9	227	16	major	major	JJ
cord-320331-wtxja5i9	227	17	histocompatibility	histocompatibility	NN
cord-320331-wtxja5i9	227	18	complexes	complex	NNS
cord-320331-wtxja5i9	227	19	(	(	-LRB-
cord-320331-wtxja5i9	227	20	MHCs	MHCs	NNPS
cord-320331-wtxja5i9	227	21	)	)	-RRB-
cord-320331-wtxja5i9	227	22	of	of	IN
cord-320331-wtxja5i9	227	23	the	the	DT
cord-320331-wtxja5i9	227	24	virus	virus	NN
cord-320331-wtxja5i9	227	25	'	'	POS
cord-320331-wtxja5i9	227	26	intracellular	intracellular	JJ
cord-320331-wtxja5i9	227	27	presence	presence	NN
cord-320331-wtxja5i9	227	28	.	.	.
cord-320331-wtxja5i9	228	1	Concomitantly	concomitantly	RB
cord-320331-wtxja5i9	228	2	,	,	,
cord-320331-wtxja5i9	228	3	toll	toll	NN
cord-320331-wtxja5i9	228	4	-	-	HYPH
cord-320331-wtxja5i9	228	5	like	like	JJ
cord-320331-wtxja5i9	228	6	receptors	receptor	NNS
cord-320331-wtxja5i9	228	7	(	(	-LRB-
cord-320331-wtxja5i9	228	8	TLRs	TLRs	NNP
cord-320331-wtxja5i9	228	9	)	)	-RRB-
cord-320331-wtxja5i9	228	10	recognize	recognize	VBP
cord-320331-wtxja5i9	228	11	viral	viral	JJ
cord-320331-wtxja5i9	228	12	nucleic	nucleic	JJ
cord-320331-wtxja5i9	228	13	acids	acid	NNS
cord-320331-wtxja5i9	228	14	intracellularly	intracellularly	RB
cord-320331-wtxja5i9	228	15	and	and	CC
cord-320331-wtxja5i9	228	16	in	in	IN
cord-320331-wtxja5i9	228	17	effect	effect	NN
cord-320331-wtxja5i9	228	18	promotes	promote	VBZ
cord-320331-wtxja5i9	228	19	the	the	DT
cord-320331-wtxja5i9	228	20	cellular	cellular	JJ
cord-320331-wtxja5i9	228	21	expression	expression	NN
cord-320331-wtxja5i9	228	22	of	of	IN
cord-320331-wtxja5i9	228	23	interferons	interferon	NNS
cord-320331-wtxja5i9	228	24	and	and	CC
cord-320331-wtxja5i9	228	25	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	228	26	cytokines	cytokine	NNS
cord-320331-wtxja5i9	228	27	that	that	WDT
cord-320331-wtxja5i9	228	28	act	act	VBP
cord-320331-wtxja5i9	228	29	in	in	IN
cord-320331-wtxja5i9	228	30	an	an	DT
cord-320331-wtxja5i9	228	31	autocrine	autocrine	JJ
cord-320331-wtxja5i9	228	32	and	and	CC
cord-320331-wtxja5i9	228	33	paracrine	paracrine	JJ
cord-320331-wtxja5i9	228	34	fashion	fashion	NN
cord-320331-wtxja5i9	228	35	to	to	TO
cord-320331-wtxja5i9	228	36	induce	induce	VB
cord-320331-wtxja5i9	228	37	an	an	DT
cord-320331-wtxja5i9	228	38	antiviral	antiviral	JJ
cord-320331-wtxja5i9	228	39	state	state	NN
cord-320331-wtxja5i9	228	40	in	in	IN
cord-320331-wtxja5i9	228	41	the	the	DT
cord-320331-wtxja5i9	228	42	host	host	NN
cord-320331-wtxja5i9	228	43	and	and	CC
cord-320331-wtxja5i9	228	44	in	in	IN
cord-320331-wtxja5i9	228	45	nearby	nearby	JJ
cord-320331-wtxja5i9	228	46	,	,	,
cord-320331-wtxja5i9	228	47	uninfected	uninfected	JJ
cord-320331-wtxja5i9	228	48	cells	cell	NNS
cord-320331-wtxja5i9	228	49	via	via	IN
cord-320331-wtxja5i9	228	50	the	the	DT
cord-320331-wtxja5i9	228	51	JAK	JAK	NNP
cord-320331-wtxja5i9	228	52	/	/	SYM
cord-320331-wtxja5i9	228	53	STAT	stat	NN
cord-320331-wtxja5i9	228	54	pathway	pathway	NN
cord-320331-wtxja5i9	228	55	,	,	,
cord-320331-wtxja5i9	228	56	and	and	CC
cord-320331-wtxja5i9	228	57	to	to	TO
cord-320331-wtxja5i9	228	58	alert	alert	VB
cord-320331-wtxja5i9	228	59	the	the	DT
cord-320331-wtxja5i9	228	60	immune	immune	JJ
cord-320331-wtxja5i9	228	61	cells	cell	NNS
cord-320331-wtxja5i9	228	62	of	of	IN
cord-320331-wtxja5i9	228	63	an	an	DT
cord-320331-wtxja5i9	228	64	ongoing	ongoing	JJ
cord-320331-wtxja5i9	228	65	invasion	invasion	NN
cord-320331-wtxja5i9	228	66	[	[	-LRB-
cord-320331-wtxja5i9	228	67	52	52	CD
cord-320331-wtxja5i9	228	68	,	,	,
cord-320331-wtxja5i9	228	69	53	53	CD
cord-320331-wtxja5i9	228	70	]	]	-RRB-
cord-320331-wtxja5i9	228	71	.	.	.
cord-320331-wtxja5i9	229	1	Type	type	NN
cord-320331-wtxja5i9	229	2	I	-PRON-	PRP
cord-320331-wtxja5i9	229	3	interferons	interferon	NNS
cord-320331-wtxja5i9	229	4	have	have	VBP
cord-320331-wtxja5i9	229	5	also	also	RB
cord-320331-wtxja5i9	229	6	been	be	VBN
cord-320331-wtxja5i9	229	7	shown	show	VBN
cord-320331-wtxja5i9	229	8	to	to	TO
cord-320331-wtxja5i9	229	9	promote	promote	VB
cord-320331-wtxja5i9	229	10	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	229	11	synthesis	synthesis	NN
cord-320331-wtxja5i9	229	12	[	[	-LRB-
cord-320331-wtxja5i9	229	13	54	54	CD
cord-320331-wtxja5i9	229	14	]	]	-RRB-
cord-320331-wtxja5i9	229	15	,	,	,
cord-320331-wtxja5i9	229	16	the	the	DT
cord-320331-wtxja5i9	229	17	latter	latter	JJ
cord-320331-wtxja5i9	229	18	acting	act	VBG
cord-320331-wtxja5i9	229	19	as	as	IN
cord-320331-wtxja5i9	229	20	a	a	DT
cord-320331-wtxja5i9	229	21	mediator	mediator	NN
cord-320331-wtxja5i9	229	22	between	between	IN
cord-320331-wtxja5i9	229	23	the	the	DT
cord-320331-wtxja5i9	229	24	thymus	thymus	NN
cord-320331-wtxja5i9	229	25	and	and	CC
cord-320331-wtxja5i9	229	26	the	the	DT
cord-320331-wtxja5i9	229	27	bone	bone	NN
cord-320331-wtxja5i9	229	28	marrow	marrow	NN
cord-320331-wtxja5i9	229	29	to	to	TO
cord-320331-wtxja5i9	229	30	promote	promote	VB
cord-320331-wtxja5i9	229	31	cellular	cellular	JJ
cord-320331-wtxja5i9	229	32	and	and	CC
cord-320331-wtxja5i9	229	33	humoral	humoral	JJ
cord-320331-wtxja5i9	229	34	types	type	NNS
cord-320331-wtxja5i9	229	35	of	of	IN
cord-320331-wtxja5i9	229	36	immunity	immunity	NN
cord-320331-wtxja5i9	229	37	[	[	-LRB-
cord-320331-wtxja5i9	229	38	55	55	CD
cord-320331-wtxja5i9	229	39	]	]	-RRB-
cord-320331-wtxja5i9	229	40	.	.	.
cord-320331-wtxja5i9	230	1	A	a	DT
cord-320331-wtxja5i9	230	2	previous	previous	JJ
cord-320331-wtxja5i9	230	3	study	study	NN
cord-320331-wtxja5i9	230	4	has	have	VBZ
cord-320331-wtxja5i9	230	5	shown	show	VBN
cord-320331-wtxja5i9	230	6	that	that	IN
cord-320331-wtxja5i9	230	7	positive	positive	JJ
cord-320331-wtxja5i9	230	8	-	-	HYPH
cord-320331-wtxja5i9	230	9	strand	strand	NN
cord-320331-wtxja5i9	230	10	RNA	RNA	NNP
cord-320331-wtxja5i9	230	11	viruses	virus	NNS
cord-320331-wtxja5i9	230	12	,	,	,
cord-320331-wtxja5i9	230	13	to	to	TO
cord-320331-wtxja5i9	230	14	which	which	WDT
cord-320331-wtxja5i9	230	15	the	the	DT
cord-320331-wtxja5i9	230	16	coronaviruses	coronaviruse	NNS
cord-320331-wtxja5i9	230	17	belong	belong	VBP
cord-320331-wtxja5i9	230	18	,	,	,
cord-320331-wtxja5i9	230	19	induce	induce	VB
cord-320331-wtxja5i9	230	20	the	the	DT
cord-320331-wtxja5i9	230	21	formation	formation	NN
cord-320331-wtxja5i9	230	22	of	of	IN
cord-320331-wtxja5i9	230	23	the	the	DT
cord-320331-wtxja5i9	230	24	endoplasmic	endoplasmic	NN
cord-320331-wtxja5i9	230	25	reticulum	reticulum	NN
cord-320331-wtxja5i9	230	26	double	double	JJ
cord-320331-wtxja5i9	230	27	membrane	membrane	NN
cord-320331-wtxja5i9	230	28	vesicles	vesicle	NNS
cord-320331-wtxja5i9	230	29	(	(	-LRB-
cord-320331-wtxja5i9	230	30	ER	ER	NNP
cord-320331-wtxja5i9	230	31	-	-	HYPH
cord-320331-wtxja5i9	230	32	DMVs	DMVs	NNPS
cord-320331-wtxja5i9	230	33	)	)	-RRB-
cord-320331-wtxja5i9	230	34	that	that	WDT
cord-320331-wtxja5i9	230	35	promote	promote	VBP
cord-320331-wtxja5i9	230	36	viral	viral	JJ
cord-320331-wtxja5i9	230	37	replication	replication	NN
cord-320331-wtxja5i9	230	38	and	and	CC
cord-320331-wtxja5i9	230	39	protect	protect	VB
cord-320331-wtxja5i9	230	40	viruses	virus	NNS
cord-320331-wtxja5i9	230	41	from	from	IN
cord-320331-wtxja5i9	230	42	immune	immune	JJ
cord-320331-wtxja5i9	230	43	detection	detection	NN
cord-320331-wtxja5i9	230	44	,	,	,
cord-320331-wtxja5i9	230	45	and	and	CC
cord-320331-wtxja5i9	230	46	J	J	NNP
cord-320331-wtxja5i9	230	47	o	o	NN
cord-320331-wtxja5i9	230	48	u	u	NN
cord-320331-wtxja5i9	230	49	r	r	NN
cord-320331-wtxja5i9	230	50	n	n	NN
cord-320331-wtxja5i9	230	51	a	a	DT
cord-320331-wtxja5i9	230	52	l	l	NN
cord-320331-wtxja5i9	230	53	P	p	NN
cord-320331-wtxja5i9	230	54	r	r	NN
cord-320331-wtxja5i9	230	55	e	e	NN
cord-320331-wtxja5i9	231	1	-p	-p	:
cord-320331-wtxja5i9	232	1	r	r	NNP
cord-320331-wtxja5i9	232	2	o	o	NN
cord-320331-wtxja5i9	232	3	o	o	NN
cord-320331-wtxja5i9	232	4	f	f	NN
cord-320331-wtxja5i9	232	5	treatment	treatment	NN
cord-320331-wtxja5i9	232	6	with	with	IN
cord-320331-wtxja5i9	232	7	interferon	interferon	NN
cord-320331-wtxja5i9	232	8	-	-	HYPH
cord-320331-wtxja5i9	232	9	beta	beta	NN
cord-320331-wtxja5i9	232	10	significantly	significantly	RB
cord-320331-wtxja5i9	232	11	reduces	reduce	VBZ
cord-320331-wtxja5i9	232	12	these	these	DT
cord-320331-wtxja5i9	232	13	viral	viral	RB
cord-320331-wtxja5i9	232	14	-	-	HYPH
cord-320331-wtxja5i9	232	15	induced	induce	VBN
cord-320331-wtxja5i9	232	16	membrane	membrane	NN
cord-320331-wtxja5i9	232	17	structures	structure	NNS
cord-320331-wtxja5i9	232	18	[	[	-LRB-
cord-320331-wtxja5i9	232	19	56	56	CD
cord-320331-wtxja5i9	232	20	]	]	-RRB-
cord-320331-wtxja5i9	232	21	.	.	.
cord-320331-wtxja5i9	233	1	Hence	hence	RB
cord-320331-wtxja5i9	233	2	,	,	,
cord-320331-wtxja5i9	233	3	suppression	suppression	NN
cord-320331-wtxja5i9	233	4	of	of	IN
cord-320331-wtxja5i9	233	5	prostaglandin	prostaglandin	JJ
cord-320331-wtxja5i9	233	6	synthesis	synthesis	NN
cord-320331-wtxja5i9	233	7	by	by	IN
cord-320331-wtxja5i9	233	8	the	the	DT
cord-320331-wtxja5i9	233	9	use	use	NN
cord-320331-wtxja5i9	233	10	of	of	IN
cord-320331-wtxja5i9	233	11	NSAIDs	NSAIDs	NNP
cord-320331-wtxja5i9	233	12	may	may	MD
cord-320331-wtxja5i9	233	13	effectively	effectively	RB
cord-320331-wtxja5i9	233	14	reduce	reduce	VB
cord-320331-wtxja5i9	233	15	cellmediated	cellmediate	VBN
cord-320331-wtxja5i9	233	16	and	and	CC
cord-320331-wtxja5i9	233	17	humoral	humoral	JJ
cord-320331-wtxja5i9	233	18	immunity	immunity	NN
cord-320331-wtxja5i9	233	19	against	against	IN
cord-320331-wtxja5i9	233	20	SARS	SARS	NNP
cord-320331-wtxja5i9	233	21	-	-	HYPH
cord-320331-wtxja5i9	233	22	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	233	23	,	,	,
cord-320331-wtxja5i9	233	24	and	and	CC
cord-320331-wtxja5i9	233	25	may	may	MD
cord-320331-wtxja5i9	233	26	modulate	modulate	VB
cord-320331-wtxja5i9	233	27	immune	immune	JJ
cord-320331-wtxja5i9	233	28	cells	cell	NNS
cord-320331-wtxja5i9	233	29	towards	towards	IN
cord-320331-wtxja5i9	233	30	the	the	DT
cord-320331-wtxja5i9	233	31	production	production	NN
cord-320331-wtxja5i9	233	32	of	of	IN
cord-320331-wtxja5i9	233	33	IL-10	IL-10	NNP
cord-320331-wtxja5i9	233	34	for	for	IN
cord-320331-wtxja5i9	233	35	T	t	NN
cord-320331-wtxja5i9	233	36	-	-	HYPH
cord-320331-wtxja5i9	233	37	cell	cell	NN
cord-320331-wtxja5i9	233	38	suppression	suppression	NN
cord-320331-wtxja5i9	233	39	and	and	CC
cord-320331-wtxja5i9	233	40	suppression	suppression	NN
cord-320331-wtxja5i9	233	41	of	of	IN
cord-320331-wtxja5i9	233	42	phagocytosis	phagocytosis	NN
cord-320331-wtxja5i9	233	43	,	,	,
cord-320331-wtxja5i9	233	44	particularly	particularly	RB
cord-320331-wtxja5i9	233	45	by	by	IN
cord-320331-wtxja5i9	233	46	PGE	PGE	NNP
cord-320331-wtxja5i9	233	47	2	2	CD
cord-320331-wtxja5i9	233	48	[	[	-LRB-
cord-320331-wtxja5i9	233	49	57	57	CD
cord-320331-wtxja5i9	233	50	,	,	,
cord-320331-wtxja5i9	233	51	58	58	CD
cord-320331-wtxja5i9	233	52	]	]	-RRB-
cord-320331-wtxja5i9	233	53	.	.	.
cord-320331-wtxja5i9	234	1	It	-PRON-	PRP
cord-320331-wtxja5i9	234	2	is	be	VBZ
cord-320331-wtxja5i9	234	3	however	however	RB
cord-320331-wtxja5i9	234	4	noted	note	VBN
cord-320331-wtxja5i9	234	5	that	that	IN
cord-320331-wtxja5i9	234	6	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	234	7	such	such	JJ
cord-320331-wtxja5i9	234	8	as	as	IN
cord-320331-wtxja5i9	234	9	PGE	PGE	NNP
cord-320331-wtxja5i9	234	10	2	2	CD
cord-320331-wtxja5i9	234	11	act	act	VBP
cord-320331-wtxja5i9	234	12	differently	differently	RB
cord-320331-wtxja5i9	234	13	in	in	IN
cord-320331-wtxja5i9	234	14	different	different	JJ
cord-320331-wtxja5i9	234	15	viral	viral	JJ
cord-320331-wtxja5i9	234	16	infections	infection	NNS
cord-320331-wtxja5i9	234	17	,	,	,
cord-320331-wtxja5i9	234	18	and	and	CC
cord-320331-wtxja5i9	234	19	may	may	MD
cord-320331-wtxja5i9	234	20	promote	promote	VB
cord-320331-wtxja5i9	234	21	viral	viral	JJ
cord-320331-wtxja5i9	234	22	replication	replication	NN
cord-320331-wtxja5i9	234	23	and	and	CC
cord-320331-wtxja5i9	234	24	shedding	shed	VBG
cord-320331-wtxja5i9	234	25	in	in	IN
cord-320331-wtxja5i9	234	26	other	other	JJ
cord-320331-wtxja5i9	234	27	viruses	virus	NNS
cord-320331-wtxja5i9	234	28	,	,	,
cord-320331-wtxja5i9	234	29	such	such	JJ
cord-320331-wtxja5i9	234	30	as	as	IN
cord-320331-wtxja5i9	234	31	herpes	herpes	NNP
cord-320331-wtxja5i9	234	32	simplex	simplex	NNP
cord-320331-wtxja5i9	234	33	virus	virus	NN
cord-320331-wtxja5i9	234	34	(	(	-LRB-
cord-320331-wtxja5i9	234	35	HSV	HSV	NNP
cord-320331-wtxja5i9	234	36	)	)	-RRB-
cord-320331-wtxja5i9	234	37	,	,	,
cord-320331-wtxja5i9	234	38	enterovirus	enterovirus	NN
cord-320331-wtxja5i9	234	39	71	71	CD
cord-320331-wtxja5i9	234	40	,	,	,
cord-320331-wtxja5i9	234	41	and	and	CC
cord-320331-wtxja5i9	234	42	cytomegalovirus	cytomegalovirus	NN
cord-320331-wtxja5i9	234	43	,	,	,
cord-320331-wtxja5i9	234	44	to	to	TO
cord-320331-wtxja5i9	234	45	name	name	VB
cord-320331-wtxja5i9	234	46	a	a	DT
cord-320331-wtxja5i9	234	47	few	few	JJ
cord-320331-wtxja5i9	234	48	[	[	-LRB-
cord-320331-wtxja5i9	234	49	59	59	CD
cord-320331-wtxja5i9	234	50	,	,	,
cord-320331-wtxja5i9	234	51	60	60	CD
cord-320331-wtxja5i9	234	52	]	]	-RRB-
cord-320331-wtxja5i9	234	53	.	.	.
cord-320331-wtxja5i9	235	1	Hence	hence	RB
cord-320331-wtxja5i9	235	2	,	,	,
cord-320331-wtxja5i9	235	3	the	the	DT
cord-320331-wtxja5i9	235	4	effect	effect	NN
cord-320331-wtxja5i9	235	5	of	of	IN
cord-320331-wtxja5i9	235	6	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	235	7	on	on	IN
cord-320331-wtxja5i9	235	8	different	different	JJ
cord-320331-wtxja5i9	235	9	viral	viral	JJ
cord-320331-wtxja5i9	235	10	infections	infection	NNS
cord-320331-wtxja5i9	235	11	may	may	MD
cord-320331-wtxja5i9	235	12	differ	differ	VB
cord-320331-wtxja5i9	235	13	,	,	,
cord-320331-wtxja5i9	235	14	but	but	CC
cord-320331-wtxja5i9	235	15	for	for	IN
cord-320331-wtxja5i9	235	16	SARS	SARS	NNP
cord-320331-wtxja5i9	235	17	-	-	HYPH
cord-320331-wtxja5i9	235	18	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	235	19	and	and	CC
cord-320331-wtxja5i9	235	20	for	for	IN
cord-320331-wtxja5i9	235	21	other	other	JJ
cord-320331-wtxja5i9	235	22	viruses	virus	NNS
cord-320331-wtxja5i9	235	23	such	such	JJ
cord-320331-wtxja5i9	235	24	as	as	IN
cord-320331-wtxja5i9	235	25	hepatitis	hepatitis	NN
cord-320331-wtxja5i9	235	26	B	B	NNP
cord-320331-wtxja5i9	235	27	and	and	CC
cord-320331-wtxja5i9	235	28	human	human	JJ
cord-320331-wtxja5i9	235	29	immunodeficiency	immunodeficiency	NN
cord-320331-wtxja5i9	235	30	virus	virus	NN
cord-320331-wtxja5i9	235	31	(	(	-LRB-
cord-320331-wtxja5i9	235	32	HIV	HIV	NNP
cord-320331-wtxja5i9	235	33	)	)	-RRB-
cord-320331-wtxja5i9	235	34	,	,	,
cord-320331-wtxja5i9	235	35	taking	take	VBG
cord-320331-wtxja5i9	235	36	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	235	37	and	and	CC
cord-320331-wtxja5i9	235	38	other	other	JJ
cord-320331-wtxja5i9	235	39	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	235	40	of	of	IN
cord-320331-wtxja5i9	235	41	similar	similar	JJ
cord-320331-wtxja5i9	235	42	action	action	NN
cord-320331-wtxja5i9	235	43	may	may	MD
cord-320331-wtxja5i9	235	44	aggravate	aggravate	VB
cord-320331-wtxja5i9	235	45	viral	viral	JJ
cord-320331-wtxja5i9	235	46	replication	replication	NN
cord-320331-wtxja5i9	235	47	.	.	.
cord-320331-wtxja5i9	236	1	Additional	additional	JJ
cord-320331-wtxja5i9	236	2	risks	risk	NNS
cord-320331-wtxja5i9	236	3	by	by	IN
cord-320331-wtxja5i9	236	4	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	236	5	however	however	RB
cord-320331-wtxja5i9	236	6	lie	lie	VBP
cord-320331-wtxja5i9	236	7	in	in	IN
cord-320331-wtxja5i9	236	8	its	-PRON-	PRP$
cord-320331-wtxja5i9	236	9	ability	ability	NN
cord-320331-wtxja5i9	236	10	to	to	TO
cord-320331-wtxja5i9	236	11	increase	increase	VB
cord-320331-wtxja5i9	236	12	ACE2	ACE2	NNP
cord-320331-wtxja5i9	236	13	expression	expression	NN
cord-320331-wtxja5i9	236	14	by	by	IN
cord-320331-wtxja5i9	236	15	activating	activate	VBG
cord-320331-wtxja5i9	236	16	a	a	DT
cord-320331-wtxja5i9	236	17	gene	gene	NN
cord-320331-wtxja5i9	236	18	called	call	VBN
cord-320331-wtxja5i9	236	19	ADAM17	ADAM17	NNP
cord-320331-wtxja5i9	236	20	,	,	,
cord-320331-wtxja5i9	236	21	a	a	DT
cord-320331-wtxja5i9	236	22	metalloprotease	metalloprotease	NN
cord-320331-wtxja5i9	236	23	that	that	WDT
cord-320331-wtxja5i9	236	24	upregulates	upregulate	VBZ
cord-320331-wtxja5i9	236	25	ACE2	ACE2	NNP
cord-320331-wtxja5i9	236	26	by	by	IN
cord-320331-wtxja5i9	236	27	enabling	enable	VBG
cord-320331-wtxja5i9	236	28	ACE2	ACE2	NNP
cord-320331-wtxja5i9	236	29	shedding	shedding	NN
cord-320331-wtxja5i9	236	30	,	,	,
cord-320331-wtxja5i9	236	31	resulting	result	VBG
cord-320331-wtxja5i9	236	32	in	in	IN
cord-320331-wtxja5i9	236	33	increased	increase	VBN
cord-320331-wtxja5i9	236	34	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	236	35	infection	infection	NN
cord-320331-wtxja5i9	236	36	[	[	-LRB-
cord-320331-wtxja5i9	236	37	108	108	CD
cord-320331-wtxja5i9	236	38	]	]	-RRB-
cord-320331-wtxja5i9	236	39	.	.	.
cord-320331-wtxja5i9	237	1	From	from	IN
cord-320331-wtxja5i9	237	2	here	here	RB
cord-320331-wtxja5i9	237	3	,	,	,
cord-320331-wtxja5i9	237	4	severity	severity	NN
cord-320331-wtxja5i9	237	5	and	and	CC
cord-320331-wtxja5i9	237	6	susceptibility	susceptibility	NN
cord-320331-wtxja5i9	237	7	against	against	IN
cord-320331-wtxja5i9	237	8	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	237	9	is	be	VBZ
cord-320331-wtxja5i9	237	10	expected	expect	VBN
cord-320331-wtxja5i9	237	11	to	to	TO
cord-320331-wtxja5i9	237	12	increase	increase	VB
cord-320331-wtxja5i9	237	13	as	as	IN
cord-320331-wtxja5i9	237	14	viral	viral	JJ
cord-320331-wtxja5i9	237	15	load	load	NN
cord-320331-wtxja5i9	237	16	relatively	relatively	RB
cord-320331-wtxja5i9	237	17	increases	increase	VBZ
cord-320331-wtxja5i9	237	18	.	.	.
cord-320331-wtxja5i9	238	1	Only	only	RB
cord-320331-wtxja5i9	238	2	recently	recently	RB
cord-320331-wtxja5i9	238	3	,	,	,
cord-320331-wtxja5i9	238	4	a	a	DT
cord-320331-wtxja5i9	238	5	prothrombotic	prothrombotic	JJ
cord-320331-wtxja5i9	238	6	state	state	NN
cord-320331-wtxja5i9	238	7	has	have	VBZ
cord-320331-wtxja5i9	238	8	been	be	VBN
cord-320331-wtxja5i9	238	9	associated	associate	VBN
cord-320331-wtxja5i9	238	10	with	with	IN
cord-320331-wtxja5i9	238	11	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	238	12	infection	infection	NN
cord-320331-wtxja5i9	238	13	,	,	,
cord-320331-wtxja5i9	238	14	and	and	CC
cord-320331-wtxja5i9	238	15	this	this	DT
cord-320331-wtxja5i9	238	16	has	have	VBZ
cord-320331-wtxja5i9	238	17	led	lead	VBN
cord-320331-wtxja5i9	238	18	to	to	IN
cord-320331-wtxja5i9	238	19	complicated	complicated	JJ
cord-320331-wtxja5i9	238	20	clinical	clinical	JJ
cord-320331-wtxja5i9	238	21	evaluations	evaluation	NNS
cord-320331-wtxja5i9	238	22	as	as	IN
cord-320331-wtxja5i9	238	23	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	238	24	is	be	VBZ
cord-320331-wtxja5i9	238	25	slowly	slowly	RB
cord-320331-wtxja5i9	238	26	added	add	VBN
cord-320331-wtxja5i9	238	27	to	to	IN
cord-320331-wtxja5i9	238	28	the	the	DT
cord-320331-wtxja5i9	238	29	ever	ever	RB
cord-320331-wtxja5i9	238	30	increasing	increase	VBG
cord-320331-wtxja5i9	238	31	list	list	NN
cord-320331-wtxja5i9	238	32	of	of	IN
cord-320331-wtxja5i9	238	33	differentials	differential	NNS
cord-320331-wtxja5i9	238	34	for	for	IN
cord-320331-wtxja5i9	238	35	thromboembolism	thromboembolism	NN
cord-320331-wtxja5i9	238	36	.	.	.
cord-320331-wtxja5i9	239	1	Studies	study	NNS
cord-320331-wtxja5i9	239	2	included	include	VBN
cord-320331-wtxja5i9	239	3	in	in	IN
cord-320331-wtxja5i9	239	4	a	a	DT
cord-320331-wtxja5i9	239	5	scoping	scoping	NN
cord-320331-wtxja5i9	239	6	review	review	NN
cord-320331-wtxja5i9	239	7	by	by	IN
cord-320331-wtxja5i9	239	8	Al	Al	NNP
cord-320331-wtxja5i9	239	9	-	-	HYPH
cord-320331-wtxja5i9	239	10	Ani	Ani	NNP
cord-320331-wtxja5i9	239	11	et	et	NNP
cord-320331-wtxja5i9	239	12	al	al	NNP
cord-320331-wtxja5i9	240	1	showed	show	VBD
cord-320331-wtxja5i9	240	2	that	that	IN
cord-320331-wtxja5i9	240	3	venous	venous	JJ
cord-320331-wtxja5i9	240	4	thromboembolism	thromboembolism	NN
cord-320331-wtxja5i9	240	5	(	(	-LRB-
cord-320331-wtxja5i9	240	6	VTE	VTE	NNP
cord-320331-wtxja5i9	240	7	)	)	-RRB-
cord-320331-wtxja5i9	240	8	occurs	occur	VBZ
cord-320331-wtxja5i9	240	9	in	in	IN
cord-320331-wtxja5i9	240	10	about	about	RB
cord-320331-wtxja5i9	240	11	20	20	CD
cord-320331-wtxja5i9	240	12	%	%	NN
cord-320331-wtxja5i9	240	13	of	of	IN
cord-320331-wtxja5i9	240	14	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	240	15	patients	patient	NNS
cord-320331-wtxja5i9	240	16	,	,	,
cord-320331-wtxja5i9	240	17	with	with	IN
cord-320331-wtxja5i9	240	18	around	around	RB
cord-320331-wtxja5i9	240	19	71.4	71.4	CD
cord-320331-wtxja5i9	240	20	%	%	NN
cord-320331-wtxja5i9	240	21	of	of	IN
cord-320331-wtxja5i9	240	22	those	those	DT
cord-320331-wtxja5i9	240	23	who	who	WP
cord-320331-wtxja5i9	240	24	died	die	VBD
cord-320331-wtxja5i9	240	25	from	from	IN
cord-320331-wtxja5i9	240	26	the	the	DT
cord-320331-wtxja5i9	240	27	disease	disease	NN
cord-320331-wtxja5i9	240	28	being	be	VBG
cord-320331-wtxja5i9	240	29	classified	classify	VBN
cord-320331-wtxja5i9	240	30	as	as	IN
cord-320331-wtxja5i9	240	31	having	have	VBG
cord-320331-wtxja5i9	240	32	disseminated	disseminate	VBN
cord-320331-wtxja5i9	240	33	intravascular	intravascular	JJ
cord-320331-wtxja5i9	240	34	coagulation	coagulation	NN
cord-320331-wtxja5i9	240	35	(	(	-LRB-
cord-320331-wtxja5i9	240	36	DIC	DIC	NNP
cord-320331-wtxja5i9	240	37	)	)	-RRB-
cord-320331-wtxja5i9	240	38	,	,	,
cord-320331-wtxja5i9	240	39	according	accord	VBG
cord-320331-wtxja5i9	240	40	to	to	IN
cord-320331-wtxja5i9	240	41	one	one	CD
cord-320331-wtxja5i9	240	42	single	single	JJ
cord-320331-wtxja5i9	240	43	-	-	HYPH
cord-320331-wtxja5i9	240	44	center	center	NN
cord-320331-wtxja5i9	240	45	study	study	NN
cord-320331-wtxja5i9	240	46	[	[	-LRB-
cord-320331-wtxja5i9	240	47	109	109	CD
cord-320331-wtxja5i9	240	48	]	]	-RRB-
cord-320331-wtxja5i9	240	49	.	.	.
cord-320331-wtxja5i9	241	1	Similarly	similarly	RB
cord-320331-wtxja5i9	241	2	,	,	,
cord-320331-wtxja5i9	241	3	a	a	DT
cord-320331-wtxja5i9	241	4	systematic	systematic	JJ
cord-320331-wtxja5i9	241	5	review	review	NN
cord-320331-wtxja5i9	241	6	and	and	CC
cord-320331-wtxja5i9	241	7	meta	meta	NNP
cord-320331-wtxja5i9	241	8	-	-	HYPH
cord-320331-wtxja5i9	241	9	analysis	analysis	NN
cord-320331-wtxja5i9	241	10	of	of	IN
cord-320331-wtxja5i9	241	11	3	3	CD
cord-320331-wtxja5i9	241	12	of	of	IN
cord-320331-wtxja5i9	241	13	the	the	DT
cord-320331-wtxja5i9	241	14	44	44	CD
cord-320331-wtxja5i9	241	15	included	include	VBN
cord-320331-wtxja5i9	241	16	studies	study	NNS
cord-320331-wtxja5i9	241	17	showed	show	VBD
cord-320331-wtxja5i9	241	18	VTE	VTE	NNP
cord-320331-wtxja5i9	241	19	as	as	IN
cord-320331-wtxja5i9	241	20	a	a	DT
cord-320331-wtxja5i9	241	21	rather	rather	RB
cord-320331-wtxja5i9	241	22	common	common	JJ
cord-320331-wtxja5i9	241	23	complication	complication	NN
cord-320331-wtxja5i9	241	24	of	of	IN
cord-320331-wtxja5i9	241	25	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	241	26	in	in	IN
cord-320331-wtxja5i9	241	27	15	15	CD
cord-320331-wtxja5i9	241	28	%	%	NN
cord-320331-wtxja5i9	241	29	of	of	IN
cord-320331-wtxja5i9	241	30	the	the	DT
cord-320331-wtxja5i9	241	31	318	318	CD
cord-320331-wtxja5i9	241	32	total	total	JJ
cord-320331-wtxja5i9	241	33	patients	patient	NNS
cord-320331-wtxja5i9	241	34	from	from	IN
cord-320331-wtxja5i9	241	35	three	three	CD
cord-320331-wtxja5i9	241	36	different	different	JJ
cord-320331-wtxja5i9	241	37	studies	study	NNS
cord-320331-wtxja5i9	241	38	[	[	-LRB-
cord-320331-wtxja5i9	241	39	110	110	CD
cord-320331-wtxja5i9	241	40	]	]	-RRB-
cord-320331-wtxja5i9	241	41	.	.	.
cord-320331-wtxja5i9	242	1	These	these	DT
cord-320331-wtxja5i9	242	2	suggest	suggest	VBP
cord-320331-wtxja5i9	242	3	that	that	IN
cord-320331-wtxja5i9	242	4	COVID-19	covid-19	CD
cord-320331-wtxja5i9	242	5	,	,	,
cord-320331-wtxja5i9	242	6	apart	apart	RB
cord-320331-wtxja5i9	242	7	from	from	IN
cord-320331-wtxja5i9	242	8	being	be	VBG
cord-320331-wtxja5i9	242	9	a	a	DT
cord-320331-wtxja5i9	242	10	mainly	mainly	RB
cord-320331-wtxja5i9	242	11	respiratory	respiratory	JJ
cord-320331-wtxja5i9	242	12	disease	disease	NN
cord-320331-wtxja5i9	242	13	,	,	,
cord-320331-wtxja5i9	242	14	is	be	VBZ
cord-320331-wtxja5i9	242	15	an	an	DT
cord-320331-wtxja5i9	242	16	ailment	ailment	NN
cord-320331-wtxja5i9	242	17	of	of	IN
cord-320331-wtxja5i9	242	18	the	the	DT
cord-320331-wtxja5i9	242	19	vasculature	vasculature	NN
cord-320331-wtxja5i9	242	20	frequently	frequently	RB
cord-320331-wtxja5i9	242	21	complicating	complicate	VBG
cord-320331-wtxja5i9	242	22	into	into	IN
cord-320331-wtxja5i9	242	23	VTE	VTE	NNP
cord-320331-wtxja5i9	242	24	,	,	,
cord-320331-wtxja5i9	242	25	which	which	WDT
cord-320331-wtxja5i9	242	26	is	be	VBZ
cord-320331-wtxja5i9	242	27	expected	expect	VBN
cord-320331-wtxja5i9	242	28	from	from	IN
cord-320331-wtxja5i9	242	29	its	-PRON-	PRP$
cord-320331-wtxja5i9	242	30	likely	likely	JJ
cord-320331-wtxja5i9	242	31	tropism	tropism	NN
cord-320331-wtxja5i9	242	32	for	for	IN
cord-320331-wtxja5i9	242	33	the	the	DT
cord-320331-wtxja5i9	242	34	endothelium	endothelium	NN
cord-320331-wtxja5i9	242	35	.	.	.
cord-320331-wtxja5i9	243	1	Since	since	IN
cord-320331-wtxja5i9	243	2	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	243	3	,	,	,
cord-320331-wtxja5i9	243	4	especially	especially	RB
cord-320331-wtxja5i9	243	5	the	the	DT
cord-320331-wtxja5i9	243	6	selective	selective	JJ
cord-320331-wtxja5i9	243	7	COX-2	COX-2	NNP
cord-320331-wtxja5i9	243	8	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	243	9	,	,	,
cord-320331-wtxja5i9	243	10	likely	likely	RB
cord-320331-wtxja5i9	243	11	affect	affect	VB
cord-320331-wtxja5i9	243	12	hemostatic	hemostatic	JJ
cord-320331-wtxja5i9	243	13	balance	balance	NN
cord-320331-wtxja5i9	243	14	by	by	IN
cord-320331-wtxja5i9	243	15	inhibiting	inhibit	VBG
cord-320331-wtxja5i9	243	16	prostacyclin	prostacyclin	JJ
cord-320331-wtxja5i9	243	17	synthesis	synthesis	NN
cord-320331-wtxja5i9	243	18	without	without	IN
cord-320331-wtxja5i9	243	19	inhibiting	inhibit	VBG
cord-320331-wtxja5i9	243	20	COX-1-induced	cox-1-induced	JJ
cord-320331-wtxja5i9	243	21	thromboxane	thromboxane	NNP
cord-320331-wtxja5i9	243	22	J	J	NNP
cord-320331-wtxja5i9	243	23	o	o	NNP
cord-320331-wtxja5i9	243	24	u	u	NN
cord-320331-wtxja5i9	243	25	r	r	NN
cord-320331-wtxja5i9	243	26	n	n	NN
cord-320331-wtxja5i9	243	27	a	a	DT
cord-320331-wtxja5i9	243	28	l	l	NN
cord-320331-wtxja5i9	243	29	P	p	NN
cord-320331-wtxja5i9	243	30	r	r	NN
cord-320331-wtxja5i9	243	31	e	e	NN
cord-320331-wtxja5i9	243	32	-p	-p	NN
cord-320331-wtxja5i9	244	1	r	r	LS
cord-320331-wtxja5i9	245	1	o	o	UH
cord-320331-wtxja5i9	245	2	o	o	NN
cord-320331-wtxja5i9	246	1	f	f	LS
cord-320331-wtxja5i9	246	2	production	production	NNP
cord-320331-wtxja5i9	246	3	,	,	,
cord-320331-wtxja5i9	246	4	a	a	DT
cord-320331-wtxja5i9	246	5	prothrombotic	prothrombotic	JJ
cord-320331-wtxja5i9	246	6	state	state	NN
cord-320331-wtxja5i9	246	7	is	be	VBZ
cord-320331-wtxja5i9	246	8	likely	likely	JJ
cord-320331-wtxja5i9	246	9	to	to	TO
cord-320331-wtxja5i9	246	10	occur	occur	VB
cord-320331-wtxja5i9	246	11	especially	especially	RB
cord-320331-wtxja5i9	246	12	among	among	IN
cord-320331-wtxja5i9	246	13	susceptible	susceptible	JJ
cord-320331-wtxja5i9	246	14	patients	patient	NNS
cord-320331-wtxja5i9	246	15	.	.	.
cord-320331-wtxja5i9	247	1	This	this	DT
cord-320331-wtxja5i9	247	2	is	be	VBZ
cord-320331-wtxja5i9	247	3	the	the	DT
cord-320331-wtxja5i9	247	4	reason	reason	NN
cord-320331-wtxja5i9	247	5	why	why	WRB
cord-320331-wtxja5i9	247	6	rofecoxib	rofecoxib	NNP
cord-320331-wtxja5i9	247	7	was	be	VBD
cord-320331-wtxja5i9	247	8	withdrawn	withdraw	VBN
cord-320331-wtxja5i9	247	9	from	from	IN
cord-320331-wtxja5i9	247	10	the	the	DT
cord-320331-wtxja5i9	247	11	market	market	NN
cord-320331-wtxja5i9	247	12	,	,	,
cord-320331-wtxja5i9	247	13	after	after	IN
cord-320331-wtxja5i9	247	14	a	a	DT
cord-320331-wtxja5i9	247	15	clinical	clinical	JJ
cord-320331-wtxja5i9	247	16	trial	trial	NN
cord-320331-wtxja5i9	247	17	found	find	VBD
cord-320331-wtxja5i9	247	18	an	an	DT
cord-320331-wtxja5i9	247	19	increased	increase	VBN
cord-320331-wtxja5i9	247	20	risk	risk	NN
cord-320331-wtxja5i9	247	21	of	of	IN
cord-320331-wtxja5i9	247	22	myocardial	myocardial	JJ
cord-320331-wtxja5i9	247	23	infarction	infarction	NN
cord-320331-wtxja5i9	247	24	and	and	CC
cord-320331-wtxja5i9	247	25	stroke	stroke	NN
cord-320331-wtxja5i9	247	26	in	in	IN
cord-320331-wtxja5i9	247	27	participants	participant	NNS
cord-320331-wtxja5i9	247	28	after	after	IN
cord-320331-wtxja5i9	247	29	18	18	CD
cord-320331-wtxja5i9	247	30	months	month	NNS
cord-320331-wtxja5i9	247	31	of	of	IN
cord-320331-wtxja5i9	247	32	use	use	NN
cord-320331-wtxja5i9	247	33	for	for	IN
cord-320331-wtxja5i9	247	34	colon	colon	NN
cord-320331-wtxja5i9	247	35	cancer	cancer	NN
cord-320331-wtxja5i9	247	36	prevention	prevention	NN
cord-320331-wtxja5i9	247	37	,	,	,
cord-320331-wtxja5i9	247	38	which	which	WDT
cord-320331-wtxja5i9	247	39	is	be	VBZ
cord-320331-wtxja5i9	247	40	likely	likely	JJ
cord-320331-wtxja5i9	247	41	to	to	TO
cord-320331-wtxja5i9	247	42	be	be	VB
cord-320331-wtxja5i9	247	43	a	a	DT
cord-320331-wtxja5i9	247	44	class	class	NN
cord-320331-wtxja5i9	247	45	effect	effect	NN
cord-320331-wtxja5i9	247	46	[	[	-LRB-
cord-320331-wtxja5i9	247	47	111	111	CD
cord-320331-wtxja5i9	247	48	]	]	-RRB-
cord-320331-wtxja5i9	247	49	.	.	.
cord-320331-wtxja5i9	248	1	This	this	DT
cord-320331-wtxja5i9	248	2	points	point	VBZ
cord-320331-wtxja5i9	248	3	to	to	IN
cord-320331-wtxja5i9	248	4	a	a	DT
cord-320331-wtxja5i9	248	5	possible	possible	JJ
cord-320331-wtxja5i9	248	6	risk	risk	NN
cord-320331-wtxja5i9	248	7	of	of	IN
cord-320331-wtxja5i9	248	8	VTE	VTE	NNP
cord-320331-wtxja5i9	248	9	or	or	CC
cord-320331-wtxja5i9	248	10	other	other	JJ
cord-320331-wtxja5i9	248	11	thromboembolic	thromboembolic	JJ
cord-320331-wtxja5i9	248	12	events	event	NNS
cord-320331-wtxja5i9	248	13	in	in	IN
cord-320331-wtxja5i9	248	14	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	248	15	patients	patient	NNS
cord-320331-wtxja5i9	248	16	with	with	IN
cord-320331-wtxja5i9	248	17	multiple	multiple	JJ
cord-320331-wtxja5i9	248	18	co	co	NNS
cord-320331-wtxja5i9	248	19	-	-	NNS
cord-320331-wtxja5i9	248	20	morbidities	morbidity	NNS
cord-320331-wtxja5i9	248	21	taking	take	VBG
cord-320331-wtxja5i9	248	22	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	248	23	,	,	,
cord-320331-wtxja5i9	248	24	although	although	IN
cord-320331-wtxja5i9	248	25	evidence	evidence	NN
cord-320331-wtxja5i9	248	26	is	be	VBZ
cord-320331-wtxja5i9	248	27	not	not	RB
cord-320331-wtxja5i9	248	28	yet	yet	RB
cord-320331-wtxja5i9	248	29	clear	clear	JJ
cord-320331-wtxja5i9	248	30	.	.	.
cord-320331-wtxja5i9	249	1	To	to	IN
cord-320331-wtxja5i9	249	2	the	the	DT
cord-320331-wtxja5i9	249	3	best	good	JJS
cord-320331-wtxja5i9	249	4	of	of	IN
cord-320331-wtxja5i9	249	5	our	-PRON-	PRP$
cord-320331-wtxja5i9	249	6	knowledge	knowledge	NN
cord-320331-wtxja5i9	249	7	,	,	,
cord-320331-wtxja5i9	249	8	there	there	EX
cord-320331-wtxja5i9	249	9	is	be	VBZ
cord-320331-wtxja5i9	249	10	no	no	DT
cord-320331-wtxja5i9	249	11	direct	direct	JJ
cord-320331-wtxja5i9	249	12	evidence	evidence	NN
cord-320331-wtxja5i9	249	13	to	to	IN
cord-320331-wtxja5i9	249	14	date	date	NN
cord-320331-wtxja5i9	249	15	of	of	IN
cord-320331-wtxja5i9	249	16	NSAID	NSAID	NNP
cord-320331-wtxja5i9	249	17	use	use	NN
cord-320331-wtxja5i9	249	18	and	and	CC
cord-320331-wtxja5i9	249	19	induced	induce	VBN
cord-320331-wtxja5i9	249	20	thromboembolism	thromboembolism	NN
cord-320331-wtxja5i9	249	21	among	among	IN
cord-320331-wtxja5i9	249	22	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	249	23	patients	patient	NNS
cord-320331-wtxja5i9	249	24	,	,	,
cord-320331-wtxja5i9	249	25	but	but	CC
cord-320331-wtxja5i9	249	26	serious	serious	JJ
cord-320331-wtxja5i9	249	27	caution	caution	NN
cord-320331-wtxja5i9	249	28	is	be	VBZ
cord-320331-wtxja5i9	249	29	advised	advise	VBN
cord-320331-wtxja5i9	249	30	because	because	IN
cord-320331-wtxja5i9	249	31	associations	association	NNS
cord-320331-wtxja5i9	249	32	between	between	IN
cord-320331-wtxja5i9	249	33	thromboembolism	thromboembolism	NN
cord-320331-wtxja5i9	249	34	and	and	CC
cord-320331-wtxja5i9	249	35	NSAID	NSAID	NNP
cord-320331-wtxja5i9	249	36	use	use	NN
cord-320331-wtxja5i9	249	37	have	have	VBP
cord-320331-wtxja5i9	249	38	been	be	VBN
cord-320331-wtxja5i9	249	39	well	well	RB
cord-320331-wtxja5i9	249	40	established	establish	VBN
cord-320331-wtxja5i9	249	41	in	in	IN
cord-320331-wtxja5i9	249	42	previous	previous	JJ
cord-320331-wtxja5i9	249	43	years	year	NNS
cord-320331-wtxja5i9	249	44	,	,	,
cord-320331-wtxja5i9	249	45	albeit	albeit	IN
cord-320331-wtxja5i9	249	46	in	in	IN
cord-320331-wtxja5i9	249	47	different	different	JJ
cord-320331-wtxja5i9	249	48	contexts	context	NNS
cord-320331-wtxja5i9	249	49	of	of	IN
cord-320331-wtxja5i9	249	50	disease	disease	NN
cord-320331-wtxja5i9	249	51	.	.	.
cord-320331-wtxja5i9	250	1	The	the	DT
cord-320331-wtxja5i9	250	2	reader	reader	NN
cord-320331-wtxja5i9	250	3	is	be	VBZ
cord-320331-wtxja5i9	250	4	referred	refer	VBN
cord-320331-wtxja5i9	250	5	to	to	IN
cord-320331-wtxja5i9	250	6	this	this	DT
cord-320331-wtxja5i9	250	7	article	article	NN
cord-320331-wtxja5i9	250	8	for	for	IN
cord-320331-wtxja5i9	250	9	an	an	DT
cord-320331-wtxja5i9	250	10	overview	overview	NN
cord-320331-wtxja5i9	250	11	[	[	-LRB-
cord-320331-wtxja5i9	250	12	112	112	CD
cord-320331-wtxja5i9	250	13	]	]	-RRB-
cord-320331-wtxja5i9	250	14	.	.	.
cord-320331-wtxja5i9	251	1	Similarly	similarly	RB
cord-320331-wtxja5i9	251	2	,	,	,
cord-320331-wtxja5i9	251	3	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	251	4	may	may	MD
cord-320331-wtxja5i9	251	5	enhance	enhance	VB
cord-320331-wtxja5i9	251	6	viral	viral	JJ
cord-320331-wtxja5i9	251	7	entry	entry	NN
cord-320331-wtxja5i9	251	8	when	when	WRB
cord-320331-wtxja5i9	251	9	provided	provide	VBN
cord-320331-wtxja5i9	251	10	for	for	IN
cord-320331-wtxja5i9	251	11	symptomatic	symptomatic	JJ
cord-320331-wtxja5i9	251	12	treatment	treatment	NN
cord-320331-wtxja5i9	251	13	of	of	IN
cord-320331-wtxja5i9	251	14	SARS	SARS	NNP
cord-320331-wtxja5i9	251	15	infection	infection	NN
cord-320331-wtxja5i9	251	16	.	.	.
cord-320331-wtxja5i9	252	1	As	as	IN
cord-320331-wtxja5i9	252	2	aforementioned	aforementioned	JJ
cord-320331-wtxja5i9	252	3	,	,	,
cord-320331-wtxja5i9	252	4	a	a	DT
cord-320331-wtxja5i9	252	5	20.7-fold	20.7-fold	CD
cord-320331-wtxja5i9	252	6	increase	increase	NN
cord-320331-wtxja5i9	252	7	in	in	IN
cord-320331-wtxja5i9	252	8	the	the	DT
cord-320331-wtxja5i9	252	9	risk	risk	NN
cord-320331-wtxja5i9	252	10	for	for	IN
cord-320331-wtxja5i9	252	11	adverse	adverse	JJ
cord-320331-wtxja5i9	252	12	outcomes	outcome	NNS
cord-320331-wtxja5i9	252	13	(	(	-LRB-
cord-320331-wtxja5i9	252	14	ICU	ICU	NNP
cord-320331-wtxja5i9	252	15	admission	admission	NN
cord-320331-wtxja5i9	252	16	/	/	SYM
cord-320331-wtxja5i9	252	17	mortality	mortality	NN
cord-320331-wtxja5i9	252	18	)	)	-RRB-
cord-320331-wtxja5i9	252	19	was	be	VBD
cord-320331-wtxja5i9	252	20	observed	observe	VBN
cord-320331-wtxja5i9	252	21	among	among	IN
cord-320331-wtxja5i9	252	22	patients	patient	NNS
cord-320331-wtxja5i9	252	23	in	in	IN
cord-320331-wtxja5i9	252	24	Hong	Hong	NNP
cord-320331-wtxja5i9	252	25	Kong	Kong	NNP
cord-320331-wtxja5i9	252	26	treated	treat	VBN
cord-320331-wtxja5i9	252	27	with	with	IN
cord-320331-wtxja5i9	252	28	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	252	29	for	for	IN
cord-320331-wtxja5i9	252	30	SARS	SARS	NNP
cord-320331-wtxja5i9	252	31	,	,	,
cord-320331-wtxja5i9	252	32	which	which	WDT
cord-320331-wtxja5i9	252	33	was	be	VBD
cord-320331-wtxja5i9	252	34	independent	independent	JJ
cord-320331-wtxja5i9	252	35	of	of	IN
cord-320331-wtxja5i9	252	36	age	age	NN
cord-320331-wtxja5i9	252	37	and	and	CC
cord-320331-wtxja5i9	252	38	disease	disease	NN
cord-320331-wtxja5i9	252	39	severity	severity	NN
cord-320331-wtxja5i9	252	40	[	[	-LRB-
cord-320331-wtxja5i9	252	41	45	45	CD
cord-320331-wtxja5i9	252	42	]	]	-RRB-
cord-320331-wtxja5i9	252	43	.	.	.
cord-320331-wtxja5i9	253	1	This	this	DT
cord-320331-wtxja5i9	253	2	may	may	MD
cord-320331-wtxja5i9	253	3	suggest	suggest	VB
cord-320331-wtxja5i9	253	4	the	the	DT
cord-320331-wtxja5i9	253	5	promotion	promotion	NN
cord-320331-wtxja5i9	253	6	of	of	IN
cord-320331-wtxja5i9	253	7	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	253	8	replication	replication	NN
cord-320331-wtxja5i9	253	9	secondary	secondary	JJ
cord-320331-wtxja5i9	253	10	to	to	IN
cord-320331-wtxja5i9	253	11	immunosuppression	immunosuppression	NN
cord-320331-wtxja5i9	253	12	,	,	,
cord-320331-wtxja5i9	253	13	or	or	CC
cord-320331-wtxja5i9	253	14	of	of	IN
cord-320331-wtxja5i9	253	15	increased	increase	VBN
cord-320331-wtxja5i9	253	16	ACE2	ACE2	NNP
cord-320331-wtxja5i9	253	17	expression	expression	NN
cord-320331-wtxja5i9	253	18	secondary	secondary	JJ
cord-320331-wtxja5i9	253	19	to	to	IN
cord-320331-wtxja5i9	253	20	osmotic	osmotic	JJ
cord-320331-wtxja5i9	253	21	diuresis	diuresis	NN
cord-320331-wtxja5i9	253	22	,	,	,
cord-320331-wtxja5i9	253	23	which	which	WDT
cord-320331-wtxja5i9	253	24	we	-PRON-	PRP
cord-320331-wtxja5i9	253	25	hypothesized	hypothesize	VBD
cord-320331-wtxja5i9	253	26	earlier	early	RBR
cord-320331-wtxja5i9	253	27	above	above	RB
cord-320331-wtxja5i9	253	28	(	(	-LRB-
cord-320331-wtxja5i9	253	29	Fig	fig	NN
cord-320331-wtxja5i9	253	30	.	.	.
cord-320331-wtxja5i9	253	31	4	4	CD
cord-320331-wtxja5i9	253	32	)	)	-RRB-
cord-320331-wtxja5i9	253	33	.	.	.
cord-320331-wtxja5i9	254	1	It	-PRON-	PRP
cord-320331-wtxja5i9	254	2	is	be	VBZ
cord-320331-wtxja5i9	254	3	important	important	JJ
cord-320331-wtxja5i9	254	4	to	to	TO
cord-320331-wtxja5i9	254	5	note	note	VB
cord-320331-wtxja5i9	254	6	,	,	,
cord-320331-wtxja5i9	254	7	however	however	RB
cord-320331-wtxja5i9	254	8	,	,	,
cord-320331-wtxja5i9	254	9	that	that	IN
cord-320331-wtxja5i9	254	10	the	the	DT
cord-320331-wtxja5i9	254	11	proposed	propose	VBN
cord-320331-wtxja5i9	254	12	effects	effect	NNS
cord-320331-wtxja5i9	254	13	of	of	IN
cord-320331-wtxja5i9	254	14	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	254	15	and	and	CC
cord-320331-wtxja5i9	254	16	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	254	17	on	on	IN
cord-320331-wtxja5i9	254	18	SARS	SARS	NNP
cord-320331-wtxja5i9	254	19	-	-	HYPH
cord-320331-wtxja5i9	254	20	CoV2	cov2	NN
cord-320331-wtxja5i9	254	21	infection	infection	NN
cord-320331-wtxja5i9	254	22	is	be	VBZ
cord-320331-wtxja5i9	254	23	applicable	applicable	JJ
cord-320331-wtxja5i9	254	24	only	only	RB
cord-320331-wtxja5i9	254	25	for	for	IN
cord-320331-wtxja5i9	254	26	the	the	DT
cord-320331-wtxja5i9	254	27	early	early	JJ
cord-320331-wtxja5i9	254	28	stages	stage	NNS
cord-320331-wtxja5i9	254	29	of	of	IN
cord-320331-wtxja5i9	254	30	the	the	DT
cord-320331-wtxja5i9	254	31	disease	disease	NN
cord-320331-wtxja5i9	254	32	.	.	.
cord-320331-wtxja5i9	255	1	During	during	IN
cord-320331-wtxja5i9	255	2	the	the	DT
cord-320331-wtxja5i9	255	3	late	late	JJ
cord-320331-wtxja5i9	255	4	stages	stage	NNS
cord-320331-wtxja5i9	255	5	,	,	,
cord-320331-wtxja5i9	255	6	such	such	JJ
cord-320331-wtxja5i9	255	7	as	as	IN
cord-320331-wtxja5i9	255	8	in	in	IN
cord-320331-wtxja5i9	255	9	acute	acute	JJ
cord-320331-wtxja5i9	255	10	respiratory	respiratory	JJ
cord-320331-wtxja5i9	255	11	distress	distress	NN
cord-320331-wtxja5i9	255	12	syndrome	syndrome	NN
cord-320331-wtxja5i9	255	13	(	(	-LRB-
cord-320331-wtxja5i9	255	14	ARDS	ARDS	NNP
cord-320331-wtxja5i9	255	15	)	)	-RRB-
cord-320331-wtxja5i9	255	16	or	or	CC
cord-320331-wtxja5i9	255	17	acute	acute	JJ
cord-320331-wtxja5i9	255	18	airway	airway	JJ
cord-320331-wtxja5i9	255	19	inflammation	inflammation	NN
cord-320331-wtxja5i9	255	20	,	,	,
cord-320331-wtxja5i9	255	21	treatment	treatment	NN
cord-320331-wtxja5i9	255	22	with	with	IN
cord-320331-wtxja5i9	255	23	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	255	24	or	or	CC
cord-320331-wtxja5i9	255	25	other	other	JJ
cord-320331-wtxja5i9	255	26	more	more	RBR
cord-320331-wtxja5i9	255	27	targeted	targeted	JJ
cord-320331-wtxja5i9	255	28	therapies	therapy	NNS
cord-320331-wtxja5i9	255	29	,	,	,
cord-320331-wtxja5i9	255	30	such	such	JJ
cord-320331-wtxja5i9	255	31	as	as	IN
cord-320331-wtxja5i9	255	32	monoclonal	monoclonal	JJ
cord-320331-wtxja5i9	255	33	antibodies	antibody	NNS
cord-320331-wtxja5i9	255	34	,	,	,
cord-320331-wtxja5i9	255	35	may	may	MD
cord-320331-wtxja5i9	255	36	be	be	VB
cord-320331-wtxja5i9	255	37	lifesaving	lifesave	VBG
cord-320331-wtxja5i9	255	38	.	.	.
cord-320331-wtxja5i9	256	1	Recently	recently	RB
cord-320331-wtxja5i9	256	2	,	,	,
cord-320331-wtxja5i9	256	3	a	a	DT
cord-320331-wtxja5i9	256	4	large	large	JJ
cord-320331-wtxja5i9	256	5	randomized	randomized	JJ
cord-320331-wtxja5i9	256	6	clinical	clinical	JJ
cord-320331-wtxja5i9	256	7	trial	trial	NN
cord-320331-wtxja5i9	256	8	called	call	VBN
cord-320331-wtxja5i9	256	9	the	the	DT
cord-320331-wtxja5i9	256	10	Randomised	Randomised	NNP
cord-320331-wtxja5i9	256	11	Evaluation	Evaluation	NNP
cord-320331-wtxja5i9	256	12	of	of	IN
cord-320331-wtxja5i9	256	13	COvid-19	COvid-19	NNP
cord-320331-wtxja5i9	256	14	thERapY	thERapY	NNP
cord-320331-wtxja5i9	257	1	(	(	-LRB-
cord-320331-wtxja5i9	257	2	RECOVERY	recovery	NN
cord-320331-wtxja5i9	257	3	)	)	-RRB-
cord-320331-wtxja5i9	257	4	trial	trial	NN
cord-320331-wtxja5i9	257	5	conducted	conduct	VBD
cord-320331-wtxja5i9	257	6	the	the	DT
cord-320331-wtxja5i9	257	7	world	world	NN
cord-320331-wtxja5i9	257	8	's	's	POS
cord-320331-wtxja5i9	257	9	largest	large	JJS
cord-320331-wtxja5i9	257	10	clinical	clinical	JJ
cord-320331-wtxja5i9	257	11	trial	trial	NN
cord-320331-wtxja5i9	257	12	on	on	IN
cord-320331-wtxja5i9	257	13	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	257	14	treatments	treatment	NNS
cord-320331-wtxja5i9	257	15	.	.	.
cord-320331-wtxja5i9	258	1	In	in	IN
cord-320331-wtxja5i9	258	2	this	this	DT
cord-320331-wtxja5i9	258	3	study	study	NN
cord-320331-wtxja5i9	258	4	they	-PRON-	PRP
cord-320331-wtxja5i9	258	5	selected	select	VBD
cord-320331-wtxja5i9	258	6	2,104	2,104	CD
cord-320331-wtxja5i9	258	7	COVID-19	covid-19	CD
cord-320331-wtxja5i9	258	8	patients	patient	NNS
cord-320331-wtxja5i9	258	9	and	and	CC
cord-320331-wtxja5i9	258	10	subjected	subject	VBD
cord-320331-wtxja5i9	258	11	them	-PRON-	PRP
cord-320331-wtxja5i9	258	12	to	to	IN
cord-320331-wtxja5i9	258	13	low	low	JJ
cord-320331-wtxja5i9	258	14	to	to	TO
cord-320331-wtxja5i9	258	15	moderate	moderate	JJ
cord-320331-wtxja5i9	258	16	dose	dose	NN
cord-320331-wtxja5i9	258	17	(	(	-LRB-
cord-320331-wtxja5i9	258	18	6mg	6mg	NN
cord-320331-wtxja5i9	258	19	/	/	SYM
cord-320331-wtxja5i9	258	20	day	day	NN
cord-320331-wtxja5i9	258	21	)	)	-RRB-
cord-320331-wtxja5i9	259	1	dexamethasone	dexamethasone	NNP
cord-320331-wtxja5i9	259	2	treatment	treatment	NN
cord-320331-wtxja5i9	259	3	,	,	,
cord-320331-wtxja5i9	259	4	which	which	WDT
cord-320331-wtxja5i9	259	5	then	then	RB
cord-320331-wtxja5i9	259	6	compared	compare	VBD
cord-320331-wtxja5i9	259	7	them	-PRON-	PRP
cord-320331-wtxja5i9	259	8	to	to	IN
cord-320331-wtxja5i9	259	9	4,321	4,321	CD
cord-320331-wtxja5i9	259	10	controls	control	NNS
cord-320331-wtxja5i9	259	11	who	who	WP
cord-320331-wtxja5i9	259	12	received	receive	VBD
cord-320331-wtxja5i9	259	13	the	the	DT
cord-320331-wtxja5i9	259	14	standard	standard	JJ
cord-320331-wtxja5i9	259	15	care	care	NN
cord-320331-wtxja5i9	259	16	for	for	IN
cord-320331-wtxja5i9	259	17	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	259	18	infection	infection	NN
cord-320331-wtxja5i9	259	19	.	.	.
cord-320331-wtxja5i9	260	1	As	as	IN
cord-320331-wtxja5i9	260	2	a	a	DT
cord-320331-wtxja5i9	260	3	result	result	NN
cord-320331-wtxja5i9	260	4	,	,	,
cord-320331-wtxja5i9	260	5	the	the	DT
cord-320331-wtxja5i9	260	6	investigators	investigator	NNS
cord-320331-wtxja5i9	260	7	discovered	discover	VBD
cord-320331-wtxja5i9	260	8	a	a	DT
cord-320331-wtxja5i9	260	9	significant	significant	JJ
cord-320331-wtxja5i9	260	10	decrease	decrease	NN
cord-320331-wtxja5i9	260	11	in	in	IN
cord-320331-wtxja5i9	260	12	patient	patient	JJ
cord-320331-wtxja5i9	260	13	deaths	death	NNS
cord-320331-wtxja5i9	260	14	.	.	.
cord-320331-wtxja5i9	261	1	Death	death	NN
cord-320331-wtxja5i9	261	2	among	among	IN
cord-320331-wtxja5i9	261	3	severely	severely	RB
cord-320331-wtxja5i9	261	4	-	-	HYPH
cord-320331-wtxja5i9	261	5	ill	ill	JJ
cord-320331-wtxja5i9	262	1	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	262	2	patients	patient	NNS
cord-320331-wtxja5i9	262	3	on	on	IN
cord-320331-wtxja5i9	262	4	ventilators	ventilator	NNS
cord-320331-wtxja5i9	262	5	were	be	VBD
cord-320331-wtxja5i9	262	6	J	J	NNP
cord-320331-wtxja5i9	262	7	o	o	NN
cord-320331-wtxja5i9	262	8	u	u	NN
cord-320331-wtxja5i9	262	9	r	r	NN
cord-320331-wtxja5i9	262	10	n	n	NN
cord-320331-wtxja5i9	262	11	a	a	DT
cord-320331-wtxja5i9	262	12	l	l	NN
cord-320331-wtxja5i9	262	13	P	p	NN
cord-320331-wtxja5i9	262	14	r	r	NN
cord-320331-wtxja5i9	262	15	e	e	NN
cord-320331-wtxja5i9	262	16	-p	-p	NN
cord-320331-wtxja5i9	263	1	r	r	LS
cord-320331-wtxja5i9	264	1	o	o	UH
cord-320331-wtxja5i9	264	2	o	o	NN
cord-320331-wtxja5i9	264	3	f	f	NN
cord-320331-wtxja5i9	264	4	reduced	reduce	VBN
cord-320331-wtxja5i9	264	5	by	by	IN
cord-320331-wtxja5i9	264	6	33	33	CD
cord-320331-wtxja5i9	264	7	%	%	NN
cord-320331-wtxja5i9	264	8	,	,	,
cord-320331-wtxja5i9	264	9	while	while	IN
cord-320331-wtxja5i9	264	10	death	death	NN
cord-320331-wtxja5i9	264	11	among	among	IN
cord-320331-wtxja5i9	264	12	patients	patient	NNS
cord-320331-wtxja5i9	264	13	requiring	require	VBG
cord-320331-wtxja5i9	264	14	oxygen	oxygen	NN
cord-320331-wtxja5i9	264	15	decreased	decrease	VBD
cord-320331-wtxja5i9	264	16	by	by	IN
cord-320331-wtxja5i9	264	17	20	20	CD
cord-320331-wtxja5i9	264	18	%	%	NN
cord-320331-wtxja5i9	264	19	[	[	-LRB-
cord-320331-wtxja5i9	264	20	66	66	CD
cord-320331-wtxja5i9	264	21	]	]	-RRB-
cord-320331-wtxja5i9	264	22	.	.	.
cord-320331-wtxja5i9	265	1	In	in	IN
cord-320331-wtxja5i9	265	2	contrast	contrast	NN
cord-320331-wtxja5i9	265	3	,	,	,
cord-320331-wtxja5i9	265	4	there	there	EX
cord-320331-wtxja5i9	265	5	was	be	VBD
cord-320331-wtxja5i9	265	6	no	no	DT
cord-320331-wtxja5i9	265	7	clinical	clinical	JJ
cord-320331-wtxja5i9	265	8	significance	significance	NN
cord-320331-wtxja5i9	265	9	seen	see	VBN
cord-320331-wtxja5i9	265	10	in	in	IN
cord-320331-wtxja5i9	265	11	patients	patient	NNS
cord-320331-wtxja5i9	265	12	with	with	IN
cord-320331-wtxja5i9	265	13	less	less	RBR
cord-320331-wtxja5i9	265	14	severe	severe	JJ
cord-320331-wtxja5i9	265	15	cases	case	NNS
cord-320331-wtxja5i9	265	16	,	,	,
cord-320331-wtxja5i9	265	17	suggesting	suggest	VBG
cord-320331-wtxja5i9	265	18	that	that	IN
cord-320331-wtxja5i9	265	19	the	the	DT
cord-320331-wtxja5i9	265	20	dexamethasone	dexamethasone	NN
cord-320331-wtxja5i9	265	21	might	may	MD
cord-320331-wtxja5i9	265	22	be	be	VB
cord-320331-wtxja5i9	265	23	more	more	RBR
cord-320331-wtxja5i9	265	24	useful	useful	JJ
cord-320331-wtxja5i9	265	25	in	in	IN
cord-320331-wtxja5i9	265	26	patients	patient	NNS
cord-320331-wtxja5i9	265	27	experiencing	experience	VBG
cord-320331-wtxja5i9	265	28	cytokine	cytokine	NN
cord-320331-wtxja5i9	265	29	-	-	HYPH
cord-320331-wtxja5i9	265	30	mediated	mediate	VBN
cord-320331-wtxja5i9	265	31	inflammation	inflammation	NN
cord-320331-wtxja5i9	265	32	.	.	.
cord-320331-wtxja5i9	266	1	This	this	DT
cord-320331-wtxja5i9	266	2	shows	show	VBZ
cord-320331-wtxja5i9	266	3	the	the	DT
cord-320331-wtxja5i9	266	4	potential	potential	NN
cord-320331-wtxja5i9	266	5	of	of	IN
cord-320331-wtxja5i9	266	6	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	266	7	to	to	TO
cord-320331-wtxja5i9	266	8	provide	provide	VB
cord-320331-wtxja5i9	266	9	benefit	benefit	NN
cord-320331-wtxja5i9	266	10	in	in	IN
cord-320331-wtxja5i9	266	11	severe	severe	JJ
cord-320331-wtxja5i9	266	12	COVID-19	covid-19	NN
cord-320331-wtxja5i9	266	13	;	;	:
cord-320331-wtxja5i9	266	14	however	however	RB
cord-320331-wtxja5i9	266	15	,	,	,
cord-320331-wtxja5i9	266	16	it	-PRON-	PRP
cord-320331-wtxja5i9	266	17	is	be	VBZ
cord-320331-wtxja5i9	266	18	noted	note	VBN
cord-320331-wtxja5i9	266	19	that	that	IN
cord-320331-wtxja5i9	266	20	great	great	JJ
cord-320331-wtxja5i9	266	21	caution	caution	NN
cord-320331-wtxja5i9	266	22	must	must	MD
cord-320331-wtxja5i9	266	23	be	be	VB
cord-320331-wtxja5i9	266	24	exercised	exercise	VBN
cord-320331-wtxja5i9	266	25	when	when	WRB
cord-320331-wtxja5i9	266	26	using	use	VBG
cord-320331-wtxja5i9	266	27	dexamethasone	dexamethasone	NN
cord-320331-wtxja5i9	266	28	,	,	,
cord-320331-wtxja5i9	266	29	as	as	IN
cord-320331-wtxja5i9	266	30	it	-PRON-	PRP
cord-320331-wtxja5i9	266	31	is	be	VBZ
cord-320331-wtxja5i9	266	32	neither	neither	CC
cord-320331-wtxja5i9	266	33	indicated	indicate	VBN
cord-320331-wtxja5i9	266	34	for	for	IN
cord-320331-wtxja5i9	266	35	mild	mild	JJ
cord-320331-wtxja5i9	266	36	cases	case	NNS
cord-320331-wtxja5i9	266	37	nor	nor	CC
cord-320331-wtxja5i9	266	38	with	with	IN
cord-320331-wtxja5i9	266	39	methylprednisolone	methylprednisolone	NNP
cord-320331-wtxja5i9	266	40	[	[	-LRB-
cord-320331-wtxja5i9	266	41	113	113	CD
cord-320331-wtxja5i9	266	42	]	]	-RRB-
cord-320331-wtxja5i9	266	43	,	,	.
cord-320331-wtxja5i9	267	1	the	the	DT
cord-320331-wtxja5i9	267	2	latter	latter	JJ
cord-320331-wtxja5i9	267	3	being	be	VBG
cord-320331-wtxja5i9	267	4	consistent	consistent	JJ
cord-320331-wtxja5i9	267	5	with	with	IN
cord-320331-wtxja5i9	267	6	our	-PRON-	PRP$
cord-320331-wtxja5i9	267	7	previous	previous	JJ
cord-320331-wtxja5i9	267	8	statement	statement	NN
cord-320331-wtxja5i9	267	9	.	.	.
cord-320331-wtxja5i9	268	1	However	however	RB
cord-320331-wtxja5i9	268	2	,	,	,
cord-320331-wtxja5i9	268	3	it	-PRON-	PRP
cord-320331-wtxja5i9	268	4	is	be	VBZ
cord-320331-wtxja5i9	268	5	not	not	RB
cord-320331-wtxja5i9	268	6	clear	clear	JJ
cord-320331-wtxja5i9	268	7	in	in	IN
cord-320331-wtxja5i9	268	8	the	the	DT
cord-320331-wtxja5i9	268	9	review	review	NN
cord-320331-wtxja5i9	268	10	if	if	IN
cord-320331-wtxja5i9	268	11	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	268	12	are	be	VBP
cord-320331-wtxja5i9	268	13	indeed	indeed	RB
cord-320331-wtxja5i9	268	14	detrimental	detrimental	JJ
cord-320331-wtxja5i9	268	15	for	for	IN
cord-320331-wtxja5i9	268	16	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	268	17	,	,	,
cord-320331-wtxja5i9	268	18	as	as	IN
cord-320331-wtxja5i9	268	19	the	the	DT
cord-320331-wtxja5i9	268	20	study	study	NN
cord-320331-wtxja5i9	268	21	they	-PRON-	PRP
cord-320331-wtxja5i9	268	22	included	include	VBD
cord-320331-wtxja5i9	268	23	,	,	,
cord-320331-wtxja5i9	268	24	which	which	WDT
cord-320331-wtxja5i9	268	25	showed	show	VBD
cord-320331-wtxja5i9	268	26	a	a	DT
cord-320331-wtxja5i9	268	27	higher	high	JJR
cord-320331-wtxja5i9	268	28	rate	rate	NN
cord-320331-wtxja5i9	268	29	of	of	IN
cord-320331-wtxja5i9	268	30	ICU	ICU	NNP
cord-320331-wtxja5i9	268	31	admissions	admission	NNS
cord-320331-wtxja5i9	268	32	among	among	IN
cord-320331-wtxja5i9	268	33	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	268	34	patients	patient	NNS
cord-320331-wtxja5i9	268	35	treated	treat	VBN
cord-320331-wtxja5i9	268	36	with	with	IN
cord-320331-wtxja5i9	268	37	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	268	38	,	,	,
cord-320331-wtxja5i9	268	39	was	be	VBD
cord-320331-wtxja5i9	268	40	only	only	RB
cord-320331-wtxja5i9	268	41	a	a	DT
cord-320331-wtxja5i9	268	42	case	case	NN
cord-320331-wtxja5i9	268	43	series	series	NN
cord-320331-wtxja5i9	268	44	and	and	CC
cord-320331-wtxja5i9	268	45	is	be	VBZ
cord-320331-wtxja5i9	268	46	at	at	IN
cord-320331-wtxja5i9	268	47	best	good	JJS
cord-320331-wtxja5i9	268	48	suggestive	suggestive	JJ
cord-320331-wtxja5i9	268	49	[	[	-LRB-
cord-320331-wtxja5i9	268	50	113	113	CD
cord-320331-wtxja5i9	268	51	]	]	-RRB-
cord-320331-wtxja5i9	268	52	.	.	.
cord-320331-wtxja5i9	269	1	Further	further	RB
cord-320331-wtxja5i9	269	2	,	,	,
cord-320331-wtxja5i9	269	3	the	the	DT
cord-320331-wtxja5i9	269	4	administration	administration	NN
cord-320331-wtxja5i9	269	5	of	of	IN
cord-320331-wtxja5i9	269	6	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	269	7	among	among	IN
cord-320331-wtxja5i9	269	8	the	the	DT
cord-320331-wtxja5i9	269	9	studies	study	NNS
cord-320331-wtxja5i9	269	10	varied	vary	VBN
cord-320331-wtxja5i9	269	11	in	in	IN
cord-320331-wtxja5i9	269	12	terms	term	NNS
cord-320331-wtxja5i9	269	13	of	of	IN
cord-320331-wtxja5i9	269	14	chronology	chronology	NN
cord-320331-wtxja5i9	269	15	,	,	,
cord-320331-wtxja5i9	269	16	with	with	IN
cord-320331-wtxja5i9	269	17	one	one	CD
cord-320331-wtxja5i9	269	18	study	study	NN
cord-320331-wtxja5i9	269	19	being	be	VBG
cord-320331-wtxja5i9	269	20	given	give	VBN
cord-320331-wtxja5i9	269	21	before	before	IN
cord-320331-wtxja5i9	269	22	ARDS	ARDS	NNP
cord-320331-wtxja5i9	269	23	and	and	CC
cord-320331-wtxja5i9	269	24	the	the	DT
cord-320331-wtxja5i9	269	25	other	other	JJ
cord-320331-wtxja5i9	269	26	during	during	IN
cord-320331-wtxja5i9	269	27	ARDS	ARDS	NNP
cord-320331-wtxja5i9	269	28	.	.	.
cord-320331-wtxja5i9	270	1	Meanwhile	meanwhile	RB
cord-320331-wtxja5i9	270	2	,	,	,
cord-320331-wtxja5i9	270	3	a	a	DT
cord-320331-wtxja5i9	270	4	rapid	rapid	JJ
cord-320331-wtxja5i9	270	5	systematic	systematic	JJ
cord-320331-wtxja5i9	270	6	review	review	NN
cord-320331-wtxja5i9	270	7	of	of	IN
cord-320331-wtxja5i9	270	8	59	59	CD
cord-320331-wtxja5i9	270	9	publications	publication	NNS
cord-320331-wtxja5i9	270	10	on	on	IN
cord-320331-wtxja5i9	270	11	inhaled	inhale	VBN
cord-320331-wtxja5i9	270	12	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	270	13	(	(	-LRB-
cord-320331-wtxja5i9	270	14	ICS	ICS	NNP
cord-320331-wtxja5i9	270	15	)	)	-RRB-
cord-320331-wtxja5i9	270	16	use	use	NN
cord-320331-wtxja5i9	270	17	in	in	IN
cord-320331-wtxja5i9	270	18	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	270	19	have	have	VBP
cord-320331-wtxja5i9	270	20	found	find	VBN
cord-320331-wtxja5i9	270	21	no	no	DT
cord-320331-wtxja5i9	270	22	sufficient	sufficient	JJ
cord-320331-wtxja5i9	270	23	evidence	evidence	NN
cord-320331-wtxja5i9	270	24	of	of	IN
cord-320331-wtxja5i9	270	25	benefit	benefit	NN
cord-320331-wtxja5i9	270	26	or	or	CC
cord-320331-wtxja5i9	270	27	harm	harm	NN
cord-320331-wtxja5i9	270	28	on	on	IN
cord-320331-wtxja5i9	270	29	clinical	clinical	JJ
cord-320331-wtxja5i9	270	30	outcomes	outcome	NNS
cord-320331-wtxja5i9	270	31	[	[	-LRB-
cord-320331-wtxja5i9	270	32	67	67	CD
cord-320331-wtxja5i9	270	33	]	]	-RRB-
cord-320331-wtxja5i9	270	34	,	,	,
cord-320331-wtxja5i9	270	35	which	which	WDT
cord-320331-wtxja5i9	270	36	reflects	reflect	VBZ
cord-320331-wtxja5i9	270	37	the	the	DT
cord-320331-wtxja5i9	270	38	scarcity	scarcity	NN
cord-320331-wtxja5i9	270	39	of	of	IN
cord-320331-wtxja5i9	270	40	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	270	41	clinical	clinical	JJ
cord-320331-wtxja5i9	270	42	studies	study	NNS
cord-320331-wtxja5i9	270	43	to	to	IN
cord-320331-wtxja5i9	270	44	date	date	NN
cord-320331-wtxja5i9	270	45	.	.	.
cord-320331-wtxja5i9	271	1	Alternatively	alternatively	RB
cord-320331-wtxja5i9	271	2	,	,	,
cord-320331-wtxja5i9	271	3	paracetamol	paracetamol	NNP
cord-320331-wtxja5i9	271	4	may	may	MD
cord-320331-wtxja5i9	271	5	be	be	VB
cord-320331-wtxja5i9	271	6	given	give	VBN
cord-320331-wtxja5i9	271	7	as	as	IN
cord-320331-wtxja5i9	271	8	first	first	JJ
cord-320331-wtxja5i9	271	9	-	-	HYPH
cord-320331-wtxja5i9	271	10	line	line	NN
cord-320331-wtxja5i9	271	11	for	for	IN
cord-320331-wtxja5i9	271	12	the	the	DT
cord-320331-wtxja5i9	271	13	management	management	NN
cord-320331-wtxja5i9	271	14	of	of	IN
cord-320331-wtxja5i9	271	15	fever	fever	NN
cord-320331-wtxja5i9	271	16	without	without	IN
cord-320331-wtxja5i9	271	17	targeting	target	VBG
cord-320331-wtxja5i9	271	18	inflammation	inflammation	NN
cord-320331-wtxja5i9	271	19	,	,	,
cord-320331-wtxja5i9	271	20	due	due	IN
cord-320331-wtxja5i9	271	21	to	to	IN
cord-320331-wtxja5i9	271	22	its	-PRON-	PRP$
cord-320331-wtxja5i9	271	23	effectiveness	effectiveness	NN
cord-320331-wtxja5i9	271	24	and	and	CC
cord-320331-wtxja5i9	271	25	safety	safety	NN
cord-320331-wtxja5i9	271	26	profile	profile	NN
cord-320331-wtxja5i9	271	27	.	.	.
cord-320331-wtxja5i9	272	1	Unlike	unlike	IN
cord-320331-wtxja5i9	272	2	the	the	DT
cord-320331-wtxja5i9	272	3	NSAIDs	NSAIDs	NNPS
cord-320331-wtxja5i9	272	4	,	,	,
cord-320331-wtxja5i9	272	5	paracetamol	paracetamol	NNP
cord-320331-wtxja5i9	272	6	is	be	VBZ
cord-320331-wtxja5i9	272	7	a	a	DT
cord-320331-wtxja5i9	272	8	weak	weak	JJ
cord-320331-wtxja5i9	272	9	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	272	10	inhibitor	inhibitor	NN
cord-320331-wtxja5i9	272	11	,	,	,
cord-320331-wtxja5i9	272	12	and	and	CC
cord-320331-wtxja5i9	272	13	in	in	IN
cord-320331-wtxja5i9	272	14	contrast	contrast	NN
cord-320331-wtxja5i9	272	15	to	to	IN
cord-320331-wtxja5i9	272	16	COX-1	cox-1	JJ
cord-320331-wtxja5i9	272	17	/	/	SYM
cord-320331-wtxja5i9	272	18	COX-2	cox-2	JJ
cord-320331-wtxja5i9	272	19	inhibition	inhibition	NN
cord-320331-wtxja5i9	272	20	,	,	,
cord-320331-wtxja5i9	272	21	it	-PRON-	PRP
cord-320331-wtxja5i9	272	22	inhibits	inhibit	VBZ
cord-320331-wtxja5i9	272	23	the	the	DT
cord-320331-wtxja5i9	272	24	COX-3	COX-3	NNP
cord-320331-wtxja5i9	272	25	isoenzyme	isoenzyme	NNS
cord-320331-wtxja5i9	272	26	,	,	,
cord-320331-wtxja5i9	272	27	which	which	WDT
cord-320331-wtxja5i9	272	28	is	be	VBZ
cord-320331-wtxja5i9	272	29	a	a	DT
cord-320331-wtxja5i9	272	30	COX-1	cox-1	JJ
cord-320331-wtxja5i9	272	31	splice	splice	NN
cord-320331-wtxja5i9	272	32	variant	variant	NN
cord-320331-wtxja5i9	272	33	abundant	abundant	JJ
cord-320331-wtxja5i9	272	34	in	in	IN
cord-320331-wtxja5i9	272	35	CNS	CNS	NNP
cord-320331-wtxja5i9	272	36	rather	rather	RB
cord-320331-wtxja5i9	272	37	than	than	IN
cord-320331-wtxja5i9	272	38	in	in	IN
cord-320331-wtxja5i9	272	39	the	the	DT
cord-320331-wtxja5i9	272	40	peripheral	peripheral	JJ
cord-320331-wtxja5i9	272	41	tissues	tissue	NNS
cord-320331-wtxja5i9	272	42	.	.	.
cord-320331-wtxja5i9	273	1	This	this	DT
cord-320331-wtxja5i9	273	2	provides	provide	VBZ
cord-320331-wtxja5i9	273	3	paracetamol	paracetamol	NN
cord-320331-wtxja5i9	273	4	with	with	IN
cord-320331-wtxja5i9	273	5	analgesic	analgesic	JJ
cord-320331-wtxja5i9	273	6	and	and	CC
cord-320331-wtxja5i9	273	7	antipyretic	antipyretic	JJ
cord-320331-wtxja5i9	273	8	properties	property	NNS
cord-320331-wtxja5i9	273	9	,	,	,
cord-320331-wtxja5i9	273	10	but	but	CC
cord-320331-wtxja5i9	273	11	with	with	IN
cord-320331-wtxja5i9	273	12	little	little	JJ
cord-320331-wtxja5i9	273	13	to	to	IN
cord-320331-wtxja5i9	273	14	no	no	DT
cord-320331-wtxja5i9	273	15	peripheral	peripheral	JJ
cord-320331-wtxja5i9	273	16	anti	anti	JJ
cord-320331-wtxja5i9	273	17	-	-	JJ
cord-320331-wtxja5i9	273	18	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	273	19	properties	property	NNS
cord-320331-wtxja5i9	273	20	[	[	-LRB-
cord-320331-wtxja5i9	273	21	29	29	CD
cord-320331-wtxja5i9	273	22	,	,	,
cord-320331-wtxja5i9	273	23	30	30	CD
cord-320331-wtxja5i9	273	24	]	]	-RRB-
cord-320331-wtxja5i9	273	25	.	.	.
cord-320331-wtxja5i9	274	1	Further	further	RB
cord-320331-wtxja5i9	274	2	,	,	,
cord-320331-wtxja5i9	274	3	paracetamol	paracetamol	NNP
cord-320331-wtxja5i9	274	4	employs	employ	VBZ
cord-320331-wtxja5i9	274	5	the	the	DT
cord-320331-wtxja5i9	274	6	serotonergic	serotonergic	JJ
cord-320331-wtxja5i9	274	7	pathway	pathway	NN
cord-320331-wtxja5i9	274	8	to	to	TO
cord-320331-wtxja5i9	274	9	provide	provide	VB
cord-320331-wtxja5i9	274	10	analgesia	analgesia	NN
cord-320331-wtxja5i9	274	11	.	.	.
cord-320331-wtxja5i9	275	1	By	by	IN
cord-320331-wtxja5i9	275	2	stimulating	stimulate	VBG
cord-320331-wtxja5i9	275	3	the	the	DT
cord-320331-wtxja5i9	275	4	descending	descend	VBG
cord-320331-wtxja5i9	275	5	serotonergic	serotonergic	JJ
cord-320331-wtxja5i9	275	6	pathway	pathway	NN
cord-320331-wtxja5i9	275	7	,	,	,
cord-320331-wtxja5i9	275	8	mediated	mediate	VBN
cord-320331-wtxja5i9	275	9	by	by	IN
cord-320331-wtxja5i9	275	10	the	the	DT
cord-320331-wtxja5i9	275	11	5-HT1A/1B	5-HT1A/1B	NNP
cord-320331-wtxja5i9	275	12	receptors	receptor	NNS
cord-320331-wtxja5i9	275	13	in	in	IN
cord-320331-wtxja5i9	275	14	the	the	DT
cord-320331-wtxja5i9	275	15	CNS	CNS	NNP
cord-320331-wtxja5i9	275	16	and	and	CC
cord-320331-wtxja5i9	275	17	acting	act	VBG
cord-320331-wtxja5i9	275	18	on	on	IN
cord-320331-wtxja5i9	275	19	afferent	afferent	JJ
cord-320331-wtxja5i9	275	20	nerve	nerve	NN
cord-320331-wtxja5i9	275	21	fibers	fiber	NNS
cord-320331-wtxja5i9	275	22	,	,	,
cord-320331-wtxja5i9	275	23	paracetamol	paracetamol	JJ
cord-320331-wtxja5i9	275	24	largely	largely	RB
cord-320331-wtxja5i9	275	25	inhibits	inhibit	VBZ
cord-320331-wtxja5i9	275	26	noxious	noxious	JJ
cord-320331-wtxja5i9	275	27	stimuli	stimulus	NNS
cord-320331-wtxja5i9	275	28	[	[	-LRB-
cord-320331-wtxja5i9	275	29	29	29	CD
cord-320331-wtxja5i9	275	30	,	,	,
cord-320331-wtxja5i9	275	31	31	31	CD
cord-320331-wtxja5i9	275	32	,	,	,
cord-320331-wtxja5i9	275	33	32	32	CD
cord-320331-wtxja5i9	275	34	]	]	-RRB-
cord-320331-wtxja5i9	275	35	.	.	.
cord-320331-wtxja5i9	276	1	In	in	IN
cord-320331-wtxja5i9	276	2	addition	addition	NN
cord-320331-wtxja5i9	276	3	,	,	,
cord-320331-wtxja5i9	276	4	paracetamol	paracetamol	NNP
cord-320331-wtxja5i9	276	5	also	also	RB
cord-320331-wtxja5i9	276	6	demonstrates	demonstrate	VBZ
cord-320331-wtxja5i9	276	7	an	an	DT
cord-320331-wtxja5i9	276	8	opioid	opioid	JJ
cord-320331-wtxja5i9	276	9	sparing	spare	VBG
cord-320331-wtxja5i9	276	10	effect	effect	NN
cord-320331-wtxja5i9	276	11	of	of	IN
cord-320331-wtxja5i9	276	12	20	20	CD
cord-320331-wtxja5i9	276	13	%	%	NN
cord-320331-wtxja5i9	276	14	that	that	WDT
cord-320331-wtxja5i9	276	15	may	may	MD
cord-320331-wtxja5i9	276	16	increase	increase	VB
cord-320331-wtxja5i9	276	17	analgesia	analgesia	NN
cord-320331-wtxja5i9	276	18	in	in	IN
cord-320331-wtxja5i9	276	19	patients	patient	NNS
cord-320331-wtxja5i9	276	20	under	under	IN
cord-320331-wtxja5i9	276	21	opioid	opioid	JJ
cord-320331-wtxja5i9	276	22	analgesics	analgesic	NNS
cord-320331-wtxja5i9	276	23	[	[	-LRB-
cord-320331-wtxja5i9	276	24	33	33	CD
cord-320331-wtxja5i9	276	25	]	]	-RRB-
cord-320331-wtxja5i9	276	26	.	.	.
cord-320331-wtxja5i9	277	1	Hence	hence	RB
cord-320331-wtxja5i9	277	2	,	,	,
cord-320331-wtxja5i9	277	3	by	by	IN
cord-320331-wtxja5i9	277	4	virtue	virtue	NN
cord-320331-wtxja5i9	277	5	of	of	IN
cord-320331-wtxja5i9	277	6	these	these	DT
cord-320331-wtxja5i9	277	7	pathways	pathway	NNS
cord-320331-wtxja5i9	277	8	,	,	,
cord-320331-wtxja5i9	277	9	paracetamol	paracetamol	NNP
cord-320331-wtxja5i9	277	10	may	may	MD
cord-320331-wtxja5i9	277	11	be	be	VB
cord-320331-wtxja5i9	277	12	a	a	DT
cord-320331-wtxja5i9	277	13	safer	safe	JJR
cord-320331-wtxja5i9	277	14	and	and	CC
cord-320331-wtxja5i9	277	15	more	more	RBR
cord-320331-wtxja5i9	277	16	effective	effective	JJ
cord-320331-wtxja5i9	277	17	alternative	alternative	NN
cord-320331-wtxja5i9	277	18	for	for	IN
cord-320331-wtxja5i9	277	19	early	early	JJ
cord-320331-wtxja5i9	277	20	symptomatic	symptomatic	JJ
cord-320331-wtxja5i9	277	21	management	management	NN
cord-320331-wtxja5i9	277	22	of	of	IN
cord-320331-wtxja5i9	277	23	headache	headache	NN
cord-320331-wtxja5i9	277	24	,	,	,
cord-320331-wtxja5i9	277	25	fever	fever	NN
cord-320331-wtxja5i9	277	26	and	and	CC
cord-320331-wtxja5i9	277	27	pain	pain	NN
cord-320331-wtxja5i9	277	28	in	in	IN
cord-320331-wtxja5i9	277	29	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	277	30	.	.	.
cord-320331-wtxja5i9	278	1	J	J	NNP
cord-320331-wtxja5i9	278	2	o	o	NNP
cord-320331-wtxja5i9	279	1	u	u	NNP
cord-320331-wtxja5i9	279	2	r	r	NNP
cord-320331-wtxja5i9	279	3	n	n	NN
cord-320331-wtxja5i9	279	4	a	a	DT
cord-320331-wtxja5i9	279	5	l	l	NN
cord-320331-wtxja5i9	279	6	P	p	NN
cord-320331-wtxja5i9	279	7	r	r	NN
cord-320331-wtxja5i9	279	8	e	e	NN
cord-320331-wtxja5i9	279	9	-p	-p	NN
cord-320331-wtxja5i9	280	1	r	r	NNP
cord-320331-wtxja5i9	280	2	o	o	NN
cord-320331-wtxja5i9	280	3	o	o	NN
cord-320331-wtxja5i9	280	4	f	f	NNP
cord-320331-wtxja5i9	280	5	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	280	6	is	be	VBZ
cord-320331-wtxja5i9	280	7	a	a	DT
cord-320331-wtxja5i9	280	8	respiratory	respiratory	JJ
cord-320331-wtxja5i9	280	9	disease	disease	NN
cord-320331-wtxja5i9	280	10	caused	cause	VBN
cord-320331-wtxja5i9	280	11	by	by	IN
cord-320331-wtxja5i9	280	12	the	the	DT
cord-320331-wtxja5i9	280	13	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	280	14	SARS	SARS	NNP
cord-320331-wtxja5i9	280	15	-	-	HYPH
cord-320331-wtxja5i9	280	16	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	280	17	,	,	,
cord-320331-wtxja5i9	280	18	and	and	CC
cord-320331-wtxja5i9	280	19	has	have	VBZ
cord-320331-wtxja5i9	280	20	caused	cause	VBN
cord-320331-wtxja5i9	280	21	a	a	DT
cord-320331-wtxja5i9	280	22	pandemic	pandemic	NN
cord-320331-wtxja5i9	280	23	by	by	IN
cord-320331-wtxja5i9	280	24	infecting	infect	VBG
cord-320331-wtxja5i9	280	25	more	more	JJR
cord-320331-wtxja5i9	280	26	than	than	IN
cord-320331-wtxja5i9	280	27	31	31	CD
cord-320331-wtxja5i9	280	28	million	million	CD
cord-320331-wtxja5i9	280	29	people	people	NNS
cord-320331-wtxja5i9	280	30	in	in	IN
cord-320331-wtxja5i9	280	31	more	more	JJR
cord-320331-wtxja5i9	280	32	than	than	IN
cord-320331-wtxja5i9	280	33	190	190	CD
cord-320331-wtxja5i9	280	34	countries	country	NNS
cord-320331-wtxja5i9	280	35	to	to	IN
cord-320331-wtxja5i9	280	36	date	date	NN
cord-320331-wtxja5i9	280	37	,	,	,
cord-320331-wtxja5i9	280	38	while	while	IN
cord-320331-wtxja5i9	280	39	claiming	claim	VBG
cord-320331-wtxja5i9	280	40	hundreds	hundred	NNS
cord-320331-wtxja5i9	280	41	of	of	IN
cord-320331-wtxja5i9	280	42	thousands	thousand	NNS
cord-320331-wtxja5i9	280	43	of	of	IN
cord-320331-wtxja5i9	280	44	lives	life	NNS
cord-320331-wtxja5i9	280	45	as	as	IN
cord-320331-wtxja5i9	280	46	it	-PRON-	PRP
cord-320331-wtxja5i9	280	47	impacts	impact	VBZ
cord-320331-wtxja5i9	280	48	heavily	heavily	RB
cord-320331-wtxja5i9	280	49	on	on	IN
cord-320331-wtxja5i9	280	50	both	both	CC
cord-320331-wtxja5i9	280	51	economy	economy	NN
cord-320331-wtxja5i9	280	52	and	and	CC
cord-320331-wtxja5i9	280	53	lifestyle	lifestyle	NN
cord-320331-wtxja5i9	280	54	.	.	.
cord-320331-wtxja5i9	281	1	Initial	initial	JJ
cord-320331-wtxja5i9	281	2	clinical	clinical	JJ
cord-320331-wtxja5i9	281	3	reports	report	NNS
cord-320331-wtxja5i9	281	4	have	have	VBP
cord-320331-wtxja5i9	281	5	shown	show	VBN
cord-320331-wtxja5i9	281	6	correlations	correlation	NNS
cord-320331-wtxja5i9	281	7	between	between	IN
cord-320331-wtxja5i9	281	8	adverse	adverse	JJ
cord-320331-wtxja5i9	281	9	outcomes	outcome	NNS
cord-320331-wtxja5i9	281	10	for	for	IN
cord-320331-wtxja5i9	281	11	COVID-19	covid-19	NN
cord-320331-wtxja5i9	281	12	and	and	CC
cord-320331-wtxja5i9	281	13	hypertension	hypertension	NN
cord-320331-wtxja5i9	281	14	,	,	,
cord-320331-wtxja5i9	281	15	which	which	WDT
cord-320331-wtxja5i9	281	16	they	-PRON-	PRP
cord-320331-wtxja5i9	281	17	attributed	attribute	VBD
cord-320331-wtxja5i9	281	18	to	to	IN
cord-320331-wtxja5i9	281	19	increased	increase	VBN
cord-320331-wtxja5i9	281	20	expression	expression	NN
cord-320331-wtxja5i9	281	21	of	of	IN
cord-320331-wtxja5i9	281	22	ACE2	ACE2	NNP
cord-320331-wtxja5i9	281	23	.	.	.
cord-320331-wtxja5i9	282	1	This	this	DT
cord-320331-wtxja5i9	282	2	was	be	VBD
cord-320331-wtxja5i9	282	3	followed	follow	VBN
cord-320331-wtxja5i9	282	4	shortly	shortly	RB
cord-320331-wtxja5i9	282	5	by	by	IN
cord-320331-wtxja5i9	282	6	anecdotal	anecdotal	JJ
cord-320331-wtxja5i9	282	7	reports	report	NNS
cord-320331-wtxja5i9	282	8	of	of	IN
cord-320331-wtxja5i9	282	9	increased	increase	VBN
cord-320331-wtxja5i9	282	10	symptom	symptom	NN
cord-320331-wtxja5i9	282	11	severity	severity	NN
cord-320331-wtxja5i9	282	12	among	among	IN
cord-320331-wtxja5i9	282	13	patients	patient	NNS
cord-320331-wtxja5i9	282	14	taking	take	VBG
cord-320331-wtxja5i9	282	15	anti	anti	JJ
cord-320331-wtxja5i9	282	16	-	-	JJ
cord-320331-wtxja5i9	282	17	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	282	18	drugs	drug	NNS
cord-320331-wtxja5i9	282	19	like	like	IN
cord-320331-wtxja5i9	282	20	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	282	21	early	early	RB
cord-320331-wtxja5i9	282	22	in	in	IN
cord-320331-wtxja5i9	282	23	the	the	DT
cord-320331-wtxja5i9	282	24	disease	disease	NN
cord-320331-wtxja5i9	282	25	,	,	,
cord-320331-wtxja5i9	282	26	which	which	WDT
cord-320331-wtxja5i9	282	27	was	be	VBD
cord-320331-wtxja5i9	282	28	later	later	RB
cord-320331-wtxja5i9	282	29	hypothesized	hypothesize	VBN
cord-320331-wtxja5i9	282	30	to	to	TO
cord-320331-wtxja5i9	282	31	be	be	VB
cord-320331-wtxja5i9	282	32	associated	associate	VBN
cord-320331-wtxja5i9	282	33	with	with	IN
cord-320331-wtxja5i9	282	34	ACE2	ACE2	NNP
cord-320331-wtxja5i9	282	35	.	.	.
cord-320331-wtxja5i9	283	1	In	in	IN
cord-320331-wtxja5i9	283	2	this	this	DT
cord-320331-wtxja5i9	283	3	paper	paper	NN
cord-320331-wtxja5i9	283	4	,	,	,
cord-320331-wtxja5i9	283	5	we	-PRON-	PRP
cord-320331-wtxja5i9	283	6	provide	provide	VBP
cord-320331-wtxja5i9	283	7	concrete	concrete	JJ
cord-320331-wtxja5i9	283	8	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	283	9	of	of	IN
cord-320331-wtxja5i9	283	10	how	how	WRB
cord-320331-wtxja5i9	283	11	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	283	12	and	and	CC
cord-320331-wtxja5i9	283	13	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	283	14	may	may	MD
cord-320331-wtxja5i9	283	15	aggravate	aggravate	VB
cord-320331-wtxja5i9	283	16	SARS	SARS	NNP
cord-320331-wtxja5i9	283	17	-	-	HYPH
cord-320331-wtxja5i9	283	18	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	283	19	infection	infection	NN
cord-320331-wtxja5i9	283	20	in	in	IN
cord-320331-wtxja5i9	283	21	the	the	DT
cord-320331-wtxja5i9	283	22	early	early	JJ
cord-320331-wtxja5i9	283	23	stages	stage	NNS
cord-320331-wtxja5i9	283	24	of	of	IN
cord-320331-wtxja5i9	283	25	disease	disease	NN
cord-320331-wtxja5i9	283	26	,	,	,
cord-320331-wtxja5i9	283	27	through	through	IN
cord-320331-wtxja5i9	283	28	their	-PRON-	PRP$
cord-320331-wtxja5i9	283	29	interaction	interaction	NN
cord-320331-wtxja5i9	283	30	with	with	IN
cord-320331-wtxja5i9	283	31	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	283	32	synthesis	synthesis	NN
cord-320331-wtxja5i9	283	33	and	and	CC
cord-320331-wtxja5i9	283	34	the	the	DT
cord-320331-wtxja5i9	283	35	RAAS	raa	NNS
cord-320331-wtxja5i9	283	36	,	,	,
cord-320331-wtxja5i9	283	37	apart	apart	RB
cord-320331-wtxja5i9	283	38	from	from	IN
cord-320331-wtxja5i9	283	39	the	the	DT
cord-320331-wtxja5i9	283	40	conventional	conventional	JJ
cord-320331-wtxja5i9	283	41	pathway	pathway	NN
cord-320331-wtxja5i9	283	42	of	of	IN
cord-320331-wtxja5i9	283	43	immunosuppression	immunosuppression	NN
cord-320331-wtxja5i9	283	44	at	at	IN
cord-320331-wtxja5i9	283	45	a	a	DT
cord-320331-wtxja5i9	283	46	time	time	NN
cord-320331-wtxja5i9	283	47	when	when	WRB
cord-320331-wtxja5i9	283	48	the	the	DT
cord-320331-wtxja5i9	283	49	body	body	NN
cord-320331-wtxja5i9	283	50	needs	need	VBZ
cord-320331-wtxja5i9	283	51	it	-PRON-	PRP
cord-320331-wtxja5i9	283	52	the	the	DT
cord-320331-wtxja5i9	283	53	most	most	RBS
cord-320331-wtxja5i9	283	54	.	.	.
cord-320331-wtxja5i9	284	1	However	however	RB
cord-320331-wtxja5i9	284	2	,	,	,
cord-320331-wtxja5i9	284	3	as	as	IN
cord-320331-wtxja5i9	284	4	evidence	evidence	NN
cord-320331-wtxja5i9	284	5	is	be	VBZ
cord-320331-wtxja5i9	284	6	often	often	RB
cord-320331-wtxja5i9	284	7	conflicting	conflict	VBG
cord-320331-wtxja5i9	284	8	and	and	CC
cord-320331-wtxja5i9	284	9	scarce	scarce	JJ
cord-320331-wtxja5i9	284	10	,	,	,
cord-320331-wtxja5i9	284	11	more	more	JJR
cord-320331-wtxja5i9	284	12	evidence	evidence	NN
cord-320331-wtxja5i9	284	13	is	be	VBZ
cord-320331-wtxja5i9	284	14	needed	need	VBN
cord-320331-wtxja5i9	284	15	to	to	TO
cord-320331-wtxja5i9	284	16	gain	gain	VB
cord-320331-wtxja5i9	284	17	a	a	DT
cord-320331-wtxja5i9	284	18	definitive	definitive	JJ
cord-320331-wtxja5i9	284	19	understanding	understanding	NN
cord-320331-wtxja5i9	284	20	of	of	IN
cord-320331-wtxja5i9	284	21	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	284	22	.	.	.
cord-320331-wtxja5i9	285	1	This	this	DT
cord-320331-wtxja5i9	285	2	research	research	NN
cord-320331-wtxja5i9	285	3	did	do	VBD
cord-320331-wtxja5i9	285	4	not	not	RB
cord-320331-wtxja5i9	285	5	receive	receive	VB
cord-320331-wtxja5i9	285	6	any	any	DT
cord-320331-wtxja5i9	285	7	specific	specific	JJ
cord-320331-wtxja5i9	285	8	grant	grant	NN
cord-320331-wtxja5i9	285	9	from	from	IN
cord-320331-wtxja5i9	285	10	funding	fund	VBG
cord-320331-wtxja5i9	285	11	agencies	agency	NNS
cord-320331-wtxja5i9	285	12	in	in	IN
cord-320331-wtxja5i9	285	13	the	the	DT
cord-320331-wtxja5i9	285	14	public	public	NN
cord-320331-wtxja5i9	285	15	,	,	,
cord-320331-wtxja5i9	285	16	commercial	commercial	JJ
cord-320331-wtxja5i9	285	17	,	,	,
cord-320331-wtxja5i9	285	18	or	or	CC
cord-320331-wtxja5i9	285	19	notfor	notfor	JJ
cord-320331-wtxja5i9	285	20	-	-	HYPH
cord-320331-wtxja5i9	285	21	profit	profit	NN
cord-320331-wtxja5i9	285	22	sectors	sector	NNS
cord-320331-wtxja5i9	285	23	.	.	.
cord-320331-wtxja5i9	286	1	The	the	DT
cord-320331-wtxja5i9	286	2	authors	author	NNS
cord-320331-wtxja5i9	286	3	do	do	VBP
cord-320331-wtxja5i9	286	4	not	not	RB
cord-320331-wtxja5i9	286	5	have	have	VB
cord-320331-wtxja5i9	286	6	any	any	DT
cord-320331-wtxja5i9	286	7	conflicts	conflict	NNS
cord-320331-wtxja5i9	286	8	of	of	IN
cord-320331-wtxja5i9	286	9	interest	interest	NN
cord-320331-wtxja5i9	286	10	to	to	TO
cord-320331-wtxja5i9	286	11	disclose	disclose	VB
cord-320331-wtxja5i9	286	12	.	.	.
cord-320331-wtxja5i9	287	1	We	-PRON-	PRP
cord-320331-wtxja5i9	287	2	would	would	MD
cord-320331-wtxja5i9	287	3	like	like	VB
cord-320331-wtxja5i9	287	4	to	to	TO
cord-320331-wtxja5i9	287	5	thank	thank	VB
cord-320331-wtxja5i9	287	6	the	the	DT
cord-320331-wtxja5i9	287	7	healthcare	healthcare	NN
cord-320331-wtxja5i9	287	8	workers	worker	NNS
cord-320331-wtxja5i9	287	9	and	and	CC
cord-320331-wtxja5i9	287	10	scientists	scientist	NNS
cord-320331-wtxja5i9	287	11	in	in	IN
cord-320331-wtxja5i9	287	12	this	this	DT
cord-320331-wtxja5i9	287	13	pandemic	pandemic	NN
cord-320331-wtxja5i9	287	14	for	for	IN
cord-320331-wtxja5i9	287	15	continually	continually	RB
cord-320331-wtxja5i9	287	16	providing	provide	VBG
cord-320331-wtxja5i9	287	17	care	care	NN
cord-320331-wtxja5i9	287	18	to	to	IN
cord-320331-wtxja5i9	287	19	COVID-19	covid-19	VB
cord-320331-wtxja5i9	287	20	patients	patient	NNS
cord-320331-wtxja5i9	287	21	and	and	CC
cord-320331-wtxja5i9	287	22	for	for	IN
cord-320331-wtxja5i9	287	23	providing	provide	VBG
cord-320331-wtxja5i9	287	24	reports	report	NNS
cord-320331-wtxja5i9	287	25	on	on	IN
cord-320331-wtxja5i9	287	26	the	the	DT
cord-320331-wtxja5i9	287	27	clinical	clinical	JJ
cord-320331-wtxja5i9	287	28	and	and	CC
cord-320331-wtxja5i9	287	29	molecular	molecular	JJ
cord-320331-wtxja5i9	287	30	aspects	aspect	NNS
cord-320331-wtxja5i9	287	31	of	of	IN
cord-320331-wtxja5i9	287	32	this	this	DT
cord-320331-wtxja5i9	287	33	disease	disease	NN
cord-320331-wtxja5i9	287	34	.	.	.
cord-320331-wtxja5i9	288	1	Dr.	Dr.	NNP
cord-320331-wtxja5i9	288	2	Rafael	Rafael	NNP
cord-320331-wtxja5i9	288	3	A.	A.	NNP
cord-320331-wtxja5i9	288	4	Manalo	Manalo	NNP
cord-320331-wtxja5i9	288	5	and	and	CC
cord-320331-wtxja5i9	288	6	Emma	Emma	NNP
cord-320331-wtxja5i9	288	7	Manalo	Manalo	NNP
cord-320331-wtxja5i9	288	8	are	be	VBP
cord-320331-wtxja5i9	288	9	acknowledged	acknowledge	VBN
cord-320331-wtxja5i9	288	10	for	for	IN
cord-320331-wtxja5i9	288	11	providing	provide	VBG
cord-320331-wtxja5i9	288	12	great	great	JJ
cord-320331-wtxja5i9	288	13	inspiration	inspiration	NN
cord-320331-wtxja5i9	288	14	in	in	IN
cord-320331-wtxja5i9	288	15	this	this	DT
cord-320331-wtxja5i9	288	16	work	work	NN
cord-320331-wtxja5i9	288	17	.	.	.
cord-320331-wtxja5i9	289	1	Revised	revise	VBN
cord-320331-wtxja5i9	289	2	Fig	Fig	NNP
cord-320331-wtxja5i9	289	3	.	.	.
cord-320331-wtxja5i9	290	1	1	1	LS
cord-320331-wtxja5i9	290	2	:	:	:
cord-320331-wtxja5i9	290	3	(	(	-LRB-
cord-320331-wtxja5i9	290	4	ARB	arb	NN
cord-320331-wtxja5i9	290	5	-	-	HYPH
cord-320331-wtxja5i9	290	6	ACEi	acei	NN
cord-320331-wtxja5i9	290	7	mismatch	mismatch	NN
cord-320331-wtxja5i9	290	8	was	be	VBD
cord-320331-wtxja5i9	290	9	now	now	RB
cord-320331-wtxja5i9	290	10	addressed	address	VBN
cord-320331-wtxja5i9	290	11	)	)	-RRB-
cord-320331-wtxja5i9	290	12	 	 	_SP
cord-320331-wtxja5i9	291	1	The	the	DT
cord-320331-wtxja5i9	291	2	RAAS	RAAS	NNP
cord-320331-wtxja5i9	291	3	is	be	VBZ
cord-320331-wtxja5i9	291	4	an	an	DT
cord-320331-wtxja5i9	291	5	important	important	JJ
cord-320331-wtxja5i9	291	6	homeostatic	homeostatic	JJ
cord-320331-wtxja5i9	291	7	mechanism	mechanism	NN
cord-320331-wtxja5i9	291	8	of	of	IN
cord-320331-wtxja5i9	291	9	the	the	DT
cord-320331-wtxja5i9	291	10	body	body	NN
cord-320331-wtxja5i9	291	11	that	that	WDT
cord-320331-wtxja5i9	291	12	involves	involve	VBZ
cord-320331-wtxja5i9	291	13	the	the	DT
cord-320331-wtxja5i9	291	14	kidney	kidney	NN
cord-320331-wtxja5i9	291	15	,	,	,
cord-320331-wtxja5i9	291	16	liver	liver	NN
cord-320331-wtxja5i9	291	17	,	,	,
cord-320331-wtxja5i9	291	18	lungs	lung	NNS
cord-320331-wtxja5i9	291	19	and	and	CC
cord-320331-wtxja5i9	291	20	adrenal	adrenal	JJ
cord-320331-wtxja5i9	291	21	glands	gland	NNS
cord-320331-wtxja5i9	291	22	,	,	,
cord-320331-wtxja5i9	291	23	which	which	WDT
cord-320331-wtxja5i9	291	24	responds	respond	VBZ
cord-320331-wtxja5i9	291	25	mainly	mainly	RB
cord-320331-wtxja5i9	291	26	to	to	IN
cord-320331-wtxja5i9	291	27	electrolyte	electrolyte	NN
cord-320331-wtxja5i9	291	28	and	and	CC
cord-320331-wtxja5i9	291	29	volume	volume	NN
cord-320331-wtxja5i9	291	30	changes	change	NNS
cord-320331-wtxja5i9	291	31	as	as	RB
cord-320331-wtxja5i9	291	32	well	well	RB
cord-320331-wtxja5i9	291	33	as	as	IN
cord-320331-wtxja5i9	291	34	to	to	IN
cord-320331-wtxja5i9	291	35	renal	renal	JJ
cord-320331-wtxja5i9	291	36	blood	blood	NN
cord-320331-wtxja5i9	291	37	flow	flow	NN
cord-320331-wtxja5i9	291	38	.	.	.
cord-320331-wtxja5i9	292	1	In	in	IN
cord-320331-wtxja5i9	292	2	times	time	NNS
cord-320331-wtxja5i9	292	3	of	of	IN
cord-320331-wtxja5i9	292	4	reduced	reduce	VBN
cord-320331-wtxja5i9	292	5	plasma	plasma	NN
cord-320331-wtxja5i9	292	6	volume	volume	NN
cord-320331-wtxja5i9	292	7	,	,	,
cord-320331-wtxja5i9	292	8	reduced	reduce	VBN
cord-320331-wtxja5i9	292	9	perfusion	perfusion	NN
cord-320331-wtxja5i9	292	10	to	to	IN
cord-320331-wtxja5i9	292	11	the	the	DT
cord-320331-wtxja5i9	292	12	kidneys	kidney	NNS
cord-320331-wtxja5i9	292	13	and	and	CC
cord-320331-wtxja5i9	292	14	to	to	IN
cord-320331-wtxja5i9	292	15	a	a	DT
cord-320331-wtxja5i9	292	16	concomitant	concomitant	JJ
cord-320331-wtxja5i9	292	17	loss	loss	NN
cord-320331-wtxja5i9	292	18	of	of	IN
cord-320331-wtxja5i9	292	19	Na	Na	NNP
cord-320331-wtxja5i9	292	20	+	+	CC
cord-320331-wtxja5i9	292	21	,	,	,
cord-320331-wtxja5i9	292	22	the	the	DT
cord-320331-wtxja5i9	292	23	juxtaglomerular	juxtaglomerular	JJ
cord-320331-wtxja5i9	292	24	cells	cell	NNS
cord-320331-wtxja5i9	292	25	of	of	IN
cord-320331-wtxja5i9	292	26	the	the	DT
cord-320331-wtxja5i9	292	27	kidney	kidney	NN
cord-320331-wtxja5i9	292	28	produce	produce	NN
cord-320331-wtxja5i9	292	29	renin	renin	NN
cord-320331-wtxja5i9	292	30	,	,	,
cord-320331-wtxja5i9	292	31	which	which	WDT
cord-320331-wtxja5i9	292	32	catalyzes	catalyze	VBZ
cord-320331-wtxja5i9	292	33	liver	liver	NN
cord-320331-wtxja5i9	292	34	angiotensinogen	angiotensinogen	NNP
cord-320331-wtxja5i9	292	35	to	to	TO
cord-320331-wtxja5i9	292	36	produce	produce	VB
cord-320331-wtxja5i9	292	37	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	293	1	I	-PRON-	PRP
cord-320331-wtxja5i9	293	2	(	(	-LRB-
cord-320331-wtxja5i9	293	3	Ang	Ang	NNP
cord-320331-wtxja5i9	293	4	I	I	NNP
cord-320331-wtxja5i9	293	5	)	)	-RRB-
cord-320331-wtxja5i9	293	6	.	.	.
cord-320331-wtxja5i9	294	1	The	the	DT
cord-320331-wtxja5i9	294	2	lungs	lung	NNS
cord-320331-wtxja5i9	294	3	then	then	RB
cord-320331-wtxja5i9	294	4	upregulate	upregulate	VB
cord-320331-wtxja5i9	294	5	angiotensinconverting	angiotensinconverting	NN
cord-320331-wtxja5i9	294	6	enzyme	enzyme	NN
cord-320331-wtxja5i9	294	7	(	(	-LRB-
cord-320331-wtxja5i9	294	8	ACE	ace	NN
cord-320331-wtxja5i9	294	9	)	)	-RRB-
cord-320331-wtxja5i9	294	10	that	that	WDT
cord-320331-wtxja5i9	294	11	converts	convert	VBZ
cord-320331-wtxja5i9	294	12	Ang	Ang	NNP
cord-320331-wtxja5i9	294	13	I	i	NN
cord-320331-wtxja5i9	294	14	to	to	IN
cord-320331-wtxja5i9	294	15	Ang	Ang	NNP
cord-320331-wtxja5i9	294	16	II	II	NNP
cord-320331-wtxja5i9	294	17	,	,	,
cord-320331-wtxja5i9	294	18	which	which	WDT
cord-320331-wtxja5i9	294	19	influences	influence	VBZ
cord-320331-wtxja5i9	294	20	the	the	DT
cord-320331-wtxja5i9	294	21	adrenal	adrenal	JJ
cord-320331-wtxja5i9	294	22	glands	gland	NNS
cord-320331-wtxja5i9	294	23	to	to	TO
cord-320331-wtxja5i9	294	24	synthesize	synthesize	VB
cord-320331-wtxja5i9	294	25	more	more	JJR
cord-320331-wtxja5i9	294	26	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	294	27	.	.	.
cord-320331-wtxja5i9	295	1	In	in	IN
cord-320331-wtxja5i9	295	2	addition	addition	NN
cord-320331-wtxja5i9	295	3	,	,	,
cord-320331-wtxja5i9	295	4	Ang	Ang	NNP
cord-320331-wtxja5i9	295	5	II	II	NNP
cord-320331-wtxja5i9	295	6	has	have	VBZ
cord-320331-wtxja5i9	295	7	a	a	DT
cord-320331-wtxja5i9	295	8	direct	direct	JJ
cord-320331-wtxja5i9	295	9	vasoconstrictive	vasoconstrictive	JJ
cord-320331-wtxja5i9	295	10	effect	effect	NN
cord-320331-wtxja5i9	295	11	.	.	.
cord-320331-wtxja5i9	296	1	Aldosterone	Aldosterone	NNP
cord-320331-wtxja5i9	296	2	(	(	-LRB-
cord-320331-wtxja5i9	296	3	mimicked	mimic	VBN
cord-320331-wtxja5i9	296	4	by	by	IN
cord-320331-wtxja5i9	296	5	other	other	JJ
cord-320331-wtxja5i9	296	6	mineralocorticoids	mineralocorticoid	NNS
cord-320331-wtxja5i9	296	7	)	)	-RRB-
cord-320331-wtxja5i9	296	8	,	,	,
cord-320331-wtxja5i9	296	9	which	which	WDT
cord-320331-wtxja5i9	296	10	is	be	VBZ
cord-320331-wtxja5i9	296	11	released	release	VBN
cord-320331-wtxja5i9	296	12	from	from	IN
cord-320331-wtxja5i9	296	13	the	the	DT
cord-320331-wtxja5i9	296	14	adrenal	adrenal	JJ
cord-320331-wtxja5i9	296	15	glands	gland	NNS
cord-320331-wtxja5i9	296	16	then	then	RB
cord-320331-wtxja5i9	296	17	influences	influence	VBZ
cord-320331-wtxja5i9	296	18	the	the	DT
cord-320331-wtxja5i9	296	19	kidneys	kidney	NNS
cord-320331-wtxja5i9	296	20	to	to	TO
cord-320331-wtxja5i9	296	21	increase	increase	VB
cord-320331-wtxja5i9	296	22	Na	Na	NNP
cord-320331-wtxja5i9	296	23	+	+	CC
cord-320331-wtxja5i9	296	24	and	and	CC
cord-320331-wtxja5i9	296	25	H2O	h2o	NN
cord-320331-wtxja5i9	296	26	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	296	27	in	in	IN
cord-320331-wtxja5i9	296	28	the	the	DT
cord-320331-wtxja5i9	296	29	distal	distal	JJ
cord-320331-wtxja5i9	296	30	convoluted	convoluted	JJ
cord-320331-wtxja5i9	296	31	tubules	tubule	NNS
cord-320331-wtxja5i9	296	32	and	and	CC
cord-320331-wtxja5i9	296	33	collecting	collect	VBG
cord-320331-wtxja5i9	296	34	ducts	duct	NNS
cord-320331-wtxja5i9	296	35	.	.	.
cord-320331-wtxja5i9	297	1	Under	under	IN
cord-320331-wtxja5i9	297	2	normal	normal	JJ
cord-320331-wtxja5i9	297	3	conditions	condition	NNS
cord-320331-wtxja5i9	297	4	,	,	,
cord-320331-wtxja5i9	297	5	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	297	6	E2	E2	NNP
cord-320331-wtxja5i9	297	7	and	and	CC
cord-320331-wtxja5i9	297	8	I2	I2	NNP
cord-320331-wtxja5i9	297	9	are	be	VBP
cord-320331-wtxja5i9	297	10	formed	form	VBN
cord-320331-wtxja5i9	297	11	which	which	WDT
cord-320331-wtxja5i9	297	12	,	,	,
cord-320331-wtxja5i9	297	13	in	in	IN
cord-320331-wtxja5i9	297	14	the	the	DT
cord-320331-wtxja5i9	297	15	kidneys	kidney	NNS
cord-320331-wtxja5i9	297	16	,	,	,
cord-320331-wtxja5i9	297	17	generally	generally	RB
cord-320331-wtxja5i9	297	18	vasodilate	vasodilate	VBP
cord-320331-wtxja5i9	297	19	the	the	DT
cord-320331-wtxja5i9	297	20	afferent	afferent	JJ
cord-320331-wtxja5i9	297	21	renal	renal	JJ
cord-320331-wtxja5i9	297	22	arterioles	arteriole	NNS
cord-320331-wtxja5i9	297	23	to	to	TO
cord-320331-wtxja5i9	297	24	increase	increase	VB
cord-320331-wtxja5i9	297	25	the	the	DT
cord-320331-wtxja5i9	297	26	glomerular	glomerular	JJ
cord-320331-wtxja5i9	297	27	filtration	filtration	NN
cord-320331-wtxja5i9	297	28	rate	rate	NN
cord-320331-wtxja5i9	297	29	(	(	-LRB-
cord-320331-wtxja5i9	297	30	GFR	GFR	NNP
cord-320331-wtxja5i9	297	31	)	)	-RRB-
cord-320331-wtxja5i9	297	32	and	and	CC
cord-320331-wtxja5i9	297	33	renal	renal	JJ
cord-320331-wtxja5i9	297	34	perfusion	perfusion	NN
cord-320331-wtxja5i9	297	35	.	.	.
cord-320331-wtxja5i9	298	1	In	in	IN
cord-320331-wtxja5i9	298	2	addition	addition	NN
cord-320331-wtxja5i9	298	3	,	,	,
cord-320331-wtxja5i9	298	4	PGE2	PGE2	NNP
cord-320331-wtxja5i9	298	5	predominantly	predominantly	RB
cord-320331-wtxja5i9	298	6	inhibits	inhibit	VBZ
cord-320331-wtxja5i9	298	7	Na	Na	NNP
cord-320331-wtxja5i9	298	8	+	+	CC
cord-320331-wtxja5i9	298	9	and	and	CC
cord-320331-wtxja5i9	298	10	H2O	h2o	NN
cord-320331-wtxja5i9	298	11	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	298	12	in	in	IN
cord-320331-wtxja5i9	298	13	the	the	DT
cord-320331-wtxja5i9	298	14	thick	thick	JJ
cord-320331-wtxja5i9	298	15	ascending	ascending	JJ
cord-320331-wtxja5i9	298	16	loop	loop	NN
cord-320331-wtxja5i9	298	17	of	of	IN
cord-320331-wtxja5i9	298	18	Henle	Henle	NNP
cord-320331-wtxja5i9	298	19	(	(	-LRB-
cord-320331-wtxja5i9	298	20	TAL	TAL	NNP
cord-320331-wtxja5i9	298	21	)	)	-RRB-
cord-320331-wtxja5i9	298	22	to	to	TO
cord-320331-wtxja5i9	298	23	induce	induce	VB
cord-320331-wtxja5i9	298	24	volume	volume	NN
cord-320331-wtxja5i9	298	25	or	or	CC
cord-320331-wtxja5i9	298	26	pressure	pressure	NN
cord-320331-wtxja5i9	298	27	natriuresis	natriuresis	NN
cord-320331-wtxja5i9	298	28	,	,	,
cord-320331-wtxja5i9	298	29	which	which	WDT
cord-320331-wtxja5i9	298	30	harmonizes	harmonize	VBZ
cord-320331-wtxja5i9	298	31	with	with	IN
cord-320331-wtxja5i9	298	32	the	the	DT
cord-320331-wtxja5i9	298	33	RAAS	RAAS	NNP
cord-320331-wtxja5i9	298	34	to	to	TO
cord-320331-wtxja5i9	298	35	maintain	maintain	VB
cord-320331-wtxja5i9	298	36	homeostasis	homeostasis	NN
cord-320331-wtxja5i9	298	37	.	.	.
cord-320331-wtxja5i9	299	1	In	in	IN
cord-320331-wtxja5i9	299	2	hypertension	hypertension	NN
cord-320331-wtxja5i9	299	3	and	and	CC
cord-320331-wtxja5i9	299	4	other	other	JJ
cord-320331-wtxja5i9	299	5	conditions	condition	NNS
cord-320331-wtxja5i9	299	6	of	of	IN
cord-320331-wtxja5i9	299	7	reduced	reduce	VBN
cord-320331-wtxja5i9	299	8	renal	renal	JJ
cord-320331-wtxja5i9	299	9	blood	blood	NN
cord-320331-wtxja5i9	299	10	flow	flow	NN
cord-320331-wtxja5i9	299	11	,	,	,
cord-320331-wtxja5i9	299	12	the	the	DT
cord-320331-wtxja5i9	299	13	effects	effect	NNS
cord-320331-wtxja5i9	299	14	of	of	IN
cord-320331-wtxja5i9	299	15	PGI2	PGI2	NNP
cord-320331-wtxja5i9	299	16	are	be	VBP
cord-320331-wtxja5i9	299	17	marked	mark	VBN
cord-320331-wtxja5i9	299	18	and	and	CC
cord-320331-wtxja5i9	299	19	there	there	EX
cord-320331-wtxja5i9	299	20	is	be	VBZ
cord-320331-wtxja5i9	299	21	increased	increase	VBN
cord-320331-wtxja5i9	299	22	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	299	23	of	of	IN
cord-320331-wtxja5i9	299	24	Na	Na	NNP
cord-320331-wtxja5i9	299	25	+	+	CC
cord-320331-wtxja5i9	299	26	and	and	CC
cord-320331-wtxja5i9	299	27	H2O.	H2O.	NNP
cord-320331-wtxja5i9	299	28	Chronic	chronic	JJ
cord-320331-wtxja5i9	299	29	use	use	NN
cord-320331-wtxja5i9	299	30	of	of	IN
cord-320331-wtxja5i9	299	31	ACE	ace	NN
cord-320331-wtxja5i9	299	32	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	299	33	(	(	-LRB-
cord-320331-wtxja5i9	299	34	ACEis	aceis	NN
cord-320331-wtxja5i9	299	35	)	)	-RRB-
cord-320331-wtxja5i9	299	36	and	and	CC
cord-320331-wtxja5i9	299	37	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	299	38	receptor	receptor	NN
cord-320331-wtxja5i9	299	39	type	type	NN
cord-320331-wtxja5i9	299	40	1	1	CD
cord-320331-wtxja5i9	299	41	blockers	blocker	NNS
cord-320331-wtxja5i9	299	42	(	(	-LRB-
cord-320331-wtxja5i9	299	43	ARBs	arb	NNS
cord-320331-wtxja5i9	299	44	)	)	-RRB-
cord-320331-wtxja5i9	299	45	can	can	MD
cord-320331-wtxja5i9	299	46	lead	lead	VB
cord-320331-wtxja5i9	299	47	to	to	IN
cord-320331-wtxja5i9	299	48	a	a	DT
cord-320331-wtxja5i9	299	49	compensatory	compensatory	JJ
cord-320331-wtxja5i9	299	50	upregulation	upregulation	NN
cord-320331-wtxja5i9	299	51	of	of	IN
cord-320331-wtxja5i9	299	52	ACE	ACE	NNP
cord-320331-wtxja5i9	299	53	and	and	CC
cord-320331-wtxja5i9	299	54	ACE2	ACE2	NNP
cord-320331-wtxja5i9	299	55	expression	expression	NN
cord-320331-wtxja5i9	299	56	,	,	,
cord-320331-wtxja5i9	299	57	which	which	WDT
cord-320331-wtxja5i9	299	58	is	be	VBZ
cord-320331-wtxja5i9	299	59	the	the	DT
cord-320331-wtxja5i9	299	60	probable	probable	JJ
cord-320331-wtxja5i9	299	61	mechanism	mechanism	NN
cord-320331-wtxja5i9	299	62	for	for	IN
cord-320331-wtxja5i9	299	63	the	the	DT
cord-320331-wtxja5i9	299	64	aggravation	aggravation	NN
cord-320331-wtxja5i9	299	65	of	of	IN
cord-320331-wtxja5i9	299	66	SARS	SARS	NNP
cord-320331-wtxja5i9	299	67	-	-	HYPH
cord-320331-wtxja5i9	299	68	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	299	69	infection	infection	NN
cord-320331-wtxja5i9	299	70	among	among	IN
cord-320331-wtxja5i9	299	71	chronic	chronic	JJ
cord-320331-wtxja5i9	299	72	hypertensives	hypertensive	NNS
cord-320331-wtxja5i9	299	73	taking	take	VBG
cord-320331-wtxja5i9	299	74	these	these	DT
cord-320331-wtxja5i9	299	75	drugs	drug	NNS
cord-320331-wtxja5i9	299	76	.	.	.
cord-320331-wtxja5i9	300	1	Arachidonic	arachidonic	JJ
cord-320331-wtxja5i9	300	2	acid	acid	NN
cord-320331-wtxja5i9	300	3	is	be	VBZ
cord-320331-wtxja5i9	300	4	converted	convert	VBN
cord-320331-wtxja5i9	300	5	to	to	IN
cord-320331-wtxja5i9	300	6	the	the	DT
cord-320331-wtxja5i9	300	7	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	300	8	and	and	CC
cord-320331-wtxja5i9	300	9	thromboxanes	thromboxane	NNS
cord-320331-wtxja5i9	300	10	by	by	IN
cord-320331-wtxja5i9	300	11	the	the	DT
cord-320331-wtxja5i9	300	12	action	action	NN
cord-320331-wtxja5i9	300	13	of	of	IN
cord-320331-wtxja5i9	300	14	cyclooxygenases	cyclooxygenases	NNP
cord-320331-wtxja5i9	300	15	COX-1	COX-1	NNP
cord-320331-wtxja5i9	300	16	and	and	CC
cord-320331-wtxja5i9	300	17	COX-2	COX-2	NNP
cord-320331-wtxja5i9	300	18	.	.	.
cord-320331-wtxja5i9	301	1	Of	of	IN
cord-320331-wtxja5i9	301	2	the	the	DT
cord-320331-wtxja5i9	301	3	four	four	CD
cord-320331-wtxja5i9	301	4	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	301	5	,	,	,
cord-320331-wtxja5i9	301	6	PGE2	PGE2	NNP
cord-320331-wtxja5i9	301	7	and	and	CC
cord-320331-wtxja5i9	301	8	PGI2	PGI2	NNP
cord-320331-wtxja5i9	301	9	promote	promote	VBP
cord-320331-wtxja5i9	301	10	optimal	optimal	JJ
cord-320331-wtxja5i9	301	11	renal	renal	JJ
cord-320331-wtxja5i9	301	12	function	function	NN
cord-320331-wtxja5i9	301	13	by	by	IN
cord-320331-wtxja5i9	301	14	dilating	dilate	VBG
cord-320331-wtxja5i9	301	15	afferent	afferent	JJ
cord-320331-wtxja5i9	301	16	renal	renal	JJ
cord-320331-wtxja5i9	301	17	arterioles	arteriole	NNS
cord-320331-wtxja5i9	301	18	and	and	CC
cord-320331-wtxja5i9	301	19	promoting	promote	VBG
cord-320331-wtxja5i9	301	20	natriuresis	natriuresis	NN
cord-320331-wtxja5i9	301	21	in	in	IN
cord-320331-wtxja5i9	301	22	normal	normal	JJ
cord-320331-wtxja5i9	301	23	conditions	condition	NNS
cord-320331-wtxja5i9	301	24	,	,	,
cord-320331-wtxja5i9	301	25	with	with	IN
cord-320331-wtxja5i9	301	26	PGI2-mediated	PGI2-mediated	NNP
cord-320331-wtxja5i9	301	27	Na	Na	NNP
cord-320331-wtxja5i9	301	28	+	+	CC
cord-320331-wtxja5i9	301	29	and	and	CC
cord-320331-wtxja5i9	301	30	H2O	h2o	NN
cord-320331-wtxja5i9	301	31	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	301	32	seen	see	VBN
cord-320331-wtxja5i9	301	33	more	more	RBR
cord-320331-wtxja5i9	301	34	evidently	evidently	RB
cord-320331-wtxja5i9	301	35	in	in	IN
cord-320331-wtxja5i9	301	36	unhealthy	unhealthy	JJ
cord-320331-wtxja5i9	301	37	individuals	individual	NNS
cord-320331-wtxja5i9	301	38	with	with	IN
cord-320331-wtxja5i9	301	39	reduced	reduce	VBN
cord-320331-wtxja5i9	301	40	renal	renal	JJ
cord-320331-wtxja5i9	301	41	perfusion	perfusion	NN
cord-320331-wtxja5i9	301	42	.	.	.
cord-320331-wtxja5i9	302	1	When	when	WRB
cord-320331-wtxja5i9	302	2	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	302	3	like	like	IN
cord-320331-wtxja5i9	302	4	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	302	5	or	or	CC
cord-320331-wtxja5i9	302	6	naproxen	naproxen	NN
cord-320331-wtxja5i9	302	7	are	be	VBP
cord-320331-wtxja5i9	302	8	taken	take	VBN
cord-320331-wtxja5i9	302	9	continuously	continuously	RB
cord-320331-wtxja5i9	302	10	,	,	,
cord-320331-wtxja5i9	302	11	the	the	DT
cord-320331-wtxja5i9	302	12	net	net	JJ
cord-320331-wtxja5i9	302	13	effects	effect	NNS
cord-320331-wtxja5i9	302	14	of	of	IN
cord-320331-wtxja5i9	302	15	COX	COX	NNP
cord-320331-wtxja5i9	302	16	inhibition	inhibition	NN
cord-320331-wtxja5i9	302	17	are	be	VBP
cord-320331-wtxja5i9	302	18	(	(	-LRB-
cord-320331-wtxja5i9	302	19	1	1	CD
cord-320331-wtxja5i9	302	20	)	)	-RRB-
cord-320331-wtxja5i9	302	21	increased	increase	VBN
cord-320331-wtxja5i9	302	22	Na	Na	NNP
cord-320331-wtxja5i9	302	23	+	+	CC
cord-320331-wtxja5i9	302	24	and	and	CC
cord-320331-wtxja5i9	302	25	H2O	h2o	NN
cord-320331-wtxja5i9	302	26	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	302	27	,	,	,
cord-320331-wtxja5i9	302	28	(	(	-LRB-
cord-320331-wtxja5i9	302	29	2	2	LS
cord-320331-wtxja5i9	302	30	)	)	-RRB-
cord-320331-wtxja5i9	302	31	reduced	reduce	VBN
cord-320331-wtxja5i9	302	32	renal	renal	JJ
cord-320331-wtxja5i9	302	33	afferent	afferent	JJ
cord-320331-wtxja5i9	302	34	arteriolar	arteriolar	JJ
cord-320331-wtxja5i9	302	35	dilatation	dilatation	NN
cord-320331-wtxja5i9	302	36	,	,	,
cord-320331-wtxja5i9	302	37	(	(	-LRB-
cord-320331-wtxja5i9	302	38	3	3	LS
cord-320331-wtxja5i9	302	39	)	)	-RRB-
cord-320331-wtxja5i9	302	40	reduced	reduce	VBN
cord-320331-wtxja5i9	302	41	glomerular	glomerular	JJ
cord-320331-wtxja5i9	302	42	filtration	filtration	NN
cord-320331-wtxja5i9	302	43	rate	rate	NN
cord-320331-wtxja5i9	302	44	(	(	-LRB-
cord-320331-wtxja5i9	302	45	GFR	GFR	NNP
cord-320331-wtxja5i9	302	46	)	)	-RRB-
cord-320331-wtxja5i9	302	47	,	,	,
cord-320331-wtxja5i9	302	48	and	and	CC
cord-320331-wtxja5i9	302	49	(	(	-LRB-
cord-320331-wtxja5i9	302	50	4	4	LS
cord-320331-wtxja5i9	302	51	)	)	-RRB-
cord-320331-wtxja5i9	302	52	an	an	DT
cord-320331-wtxja5i9	302	53	increase	increase	NN
cord-320331-wtxja5i9	302	54	in	in	IN
cord-320331-wtxja5i9	302	55	systemic	systemic	JJ
cord-320331-wtxja5i9	302	56	vascular	vascular	JJ
cord-320331-wtxja5i9	302	57	resistance	resistance	NN
cord-320331-wtxja5i9	302	58	.	.	.
cord-320331-wtxja5i9	303	1	Due	due	IN
cord-320331-wtxja5i9	303	2	to	to	IN
cord-320331-wtxja5i9	303	3	reduced	reduce	VBN
cord-320331-wtxja5i9	303	4	GFR	GFR	NNP
cord-320331-wtxja5i9	303	5	and	and	CC
cord-320331-wtxja5i9	303	6	renal	renal	JJ
cord-320331-wtxja5i9	303	7	perfusion	perfusion	NN
cord-320331-wtxja5i9	303	8	,	,	,
cord-320331-wtxja5i9	303	9	the	the	DT
cord-320331-wtxja5i9	303	10	body	body	NN
cord-320331-wtxja5i9	303	11	produces	produce	VBZ
cord-320331-wtxja5i9	303	12	greater	great	JJR
cord-320331-wtxja5i9	303	13	amounts	amount	NNS
cord-320331-wtxja5i9	303	14	of	of	IN
cord-320331-wtxja5i9	303	15	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	303	16	II	II	NNP
cord-320331-wtxja5i9	303	17	(	(	-LRB-
cord-320331-wtxja5i9	303	18	Ang	Ang	NNP
cord-320331-wtxja5i9	303	19	II	II	NNP
cord-320331-wtxja5i9	303	20	)	)	-RRB-
cord-320331-wtxja5i9	303	21	to	to	TO
cord-320331-wtxja5i9	303	22	increase	increase	VB
cord-320331-wtxja5i9	303	23	blood	blood	NN
cord-320331-wtxja5i9	303	24	flow	flow	NN
cord-320331-wtxja5i9	303	25	via	via	IN
cord-320331-wtxja5i9	303	26	increased	increase	VBN
cord-320331-wtxja5i9	303	27	plasma	plasma	NN
cord-320331-wtxja5i9	303	28	volume	volume	NN
cord-320331-wtxja5i9	303	29	.	.	.
cord-320331-wtxja5i9	304	1	However	however	RB
cord-320331-wtxja5i9	304	2	,	,	,
cord-320331-wtxja5i9	304	3	increased	increase	VBD
cord-320331-wtxja5i9	304	4	Ang	Ang	NNP
cord-320331-wtxja5i9	304	5	II	II	NNP
cord-320331-wtxja5i9	304	6	levels	level	NNS
cord-320331-wtxja5i9	304	7	leads	lead	VBZ
cord-320331-wtxja5i9	304	8	to	to	IN
cord-320331-wtxja5i9	304	9	inappropriate	inappropriate	JJ
cord-320331-wtxja5i9	304	10	vasoconstriction	vasoconstriction	NN
cord-320331-wtxja5i9	304	11	and	and	CC
cord-320331-wtxja5i9	304	12	increased	increase	VBN
cord-320331-wtxja5i9	304	13	systemic	systemic	JJ
cord-320331-wtxja5i9	304	14	vascular	vascular	JJ
cord-320331-wtxja5i9	304	15	resistance	resistance	NN
cord-320331-wtxja5i9	304	16	,	,	,
cord-320331-wtxja5i9	304	17	which	which	WDT
cord-320331-wtxja5i9	304	18	may	may	MD
cord-320331-wtxja5i9	304	19	ultimately	ultimately	RB
cord-320331-wtxja5i9	304	20	result	result	VB
cord-320331-wtxja5i9	304	21	in	in	IN
cord-320331-wtxja5i9	304	22	a	a	DT
cord-320331-wtxja5i9	304	23	vicious	vicious	JJ
cord-320331-wtxja5i9	304	24	cycle	cycle	NN
cord-320331-wtxja5i9	304	25	due	due	JJ
cord-320331-wtxja5i9	304	26	to	to	IN
cord-320331-wtxja5i9	304	27	feedback	feedback	VB
cord-320331-wtxja5i9	304	28	compensation	compensation	NN
cord-320331-wtxja5i9	304	29	from	from	IN
cord-320331-wtxja5i9	304	30	Ang	Ang	NNP
cord-320331-wtxja5i9	304	31	II	II	NNP
cord-320331-wtxja5i9	304	32	in	in	IN
cord-320331-wtxja5i9	304	33	susceptible	susceptible	JJ
cord-320331-wtxja5i9	304	34	patients	patient	NNS
cord-320331-wtxja5i9	304	35	.	.	.
cord-320331-wtxja5i9	305	1	Subsequently	subsequently	RB
cord-320331-wtxja5i9	305	2	,	,	,
cord-320331-wtxja5i9	305	3	an	an	DT
cord-320331-wtxja5i9	305	4	upregulation	upregulation	NN
cord-320331-wtxja5i9	305	5	of	of	IN
cord-320331-wtxja5i9	305	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	305	7	expression	expression	NN
cord-320331-wtxja5i9	305	8	is	be	VBZ
cord-320331-wtxja5i9	305	9	expected	expect	VBN
cord-320331-wtxja5i9	305	10	to	to	TO
cord-320331-wtxja5i9	305	11	counteract	counteract	VB
cord-320331-wtxja5i9	305	12	Ang	Ang	NNP
cord-320331-wtxja5i9	305	13	II	II	NNP
cord-320331-wtxja5i9	305	14	providing	provide	VBG
cord-320331-wtxja5i9	305	15	its	-PRON-	PRP$
cord-320331-wtxja5i9	305	16	catabolic	catabolic	JJ
cord-320331-wtxja5i9	305	17	pathway	pathway	NN
cord-320331-wtxja5i9	305	18	to	to	TO
cord-320331-wtxja5i9	305	19	produce	produce	VB
cord-320331-wtxja5i9	305	20	vasodilator	vasodilator	NN
cord-320331-wtxja5i9	305	21	and	and	CC
cord-320331-wtxja5i9	305	22	natriuretic	natriuretic	JJ
cord-320331-wtxja5i9	305	23	angiotensins	angiotensin	NNS
cord-320331-wtxja5i9	305	24	(	(	-LRB-
cord-320331-wtxja5i9	305	25	1	1	CD
cord-320331-wtxja5i9	305	26	)	)	-RRB-
cord-320331-wtxja5i9	305	27	(	(	-LRB-
cord-320331-wtxja5i9	305	28	2	2	LS
cord-320331-wtxja5i9	305	29	)	)	-RRB-
cord-320331-wtxja5i9	305	30	(	(	-LRB-
cord-320331-wtxja5i9	305	31	3	3	LS
cord-320331-wtxja5i9	305	32	)	)	-RRB-
cord-320331-wtxja5i9	305	33	(	(	-LRB-
cord-320331-wtxja5i9	305	34	4	4	LS
cord-320331-wtxja5i9	305	35	)	)	-RRB-
cord-320331-wtxja5i9	305	36	(	(	-LRB-
cord-320331-wtxja5i9	305	37	5	5	LS
cord-320331-wtxja5i9	305	38	)	)	-RRB-
cord-320331-wtxja5i9	305	39	(	(	-LRB-
cord-320331-wtxja5i9	305	40	6	6	LS
cord-320331-wtxja5i9	305	41	)	)	-RRB-
cord-320331-wtxja5i9	305	42	(	(	-LRB-
cord-320331-wtxja5i9	305	43	7	7	CD
cord-320331-wtxja5i9	305	44	)	)	-RRB-
cord-320331-wtxja5i9	305	45	.	.	.
cord-320331-wtxja5i9	306	1	This	this	DT
cord-320331-wtxja5i9	306	2	compensatory	compensatory	JJ
cord-320331-wtxja5i9	306	3	increase	increase	NN
cord-320331-wtxja5i9	306	4	in	in	IN
cord-320331-wtxja5i9	306	5	ACE2	ACE2	NNP
cord-320331-wtxja5i9	306	6	expression	expression	NN
cord-320331-wtxja5i9	306	7	from	from	IN
cord-320331-wtxja5i9	306	8	NSAID	NSAID	NNP
cord-320331-wtxja5i9	306	9	intake	intake	NN
cord-320331-wtxja5i9	306	10	,	,	,
cord-320331-wtxja5i9	306	11	which	which	WDT
cord-320331-wtxja5i9	306	12	is	be	VBZ
cord-320331-wtxja5i9	306	13	aggravated	aggravate	VBN
cord-320331-wtxja5i9	306	14	in	in	IN
cord-320331-wtxja5i9	306	15	unhealthy	unhealthy	JJ
cord-320331-wtxja5i9	306	16	individuals	individual	NNS
cord-320331-wtxja5i9	306	17	such	such	JJ
cord-320331-wtxja5i9	306	18	as	as	IN
cord-320331-wtxja5i9	306	19	those	those	DT
cord-320331-wtxja5i9	306	20	with	with	IN
cord-320331-wtxja5i9	306	21	hypertension	hypertension	NN
cord-320331-wtxja5i9	306	22	,	,	,
cord-320331-wtxja5i9	306	23	is	be	VBZ
cord-320331-wtxja5i9	306	24	the	the	DT
cord-320331-wtxja5i9	306	25	proposed	propose	VBN
cord-320331-wtxja5i9	306	26	mechanism	mechanism	NN
cord-320331-wtxja5i9	306	27	by	by	IN
cord-320331-wtxja5i9	306	28	which	which	WDT
cord-320331-wtxja5i9	306	29	SARS	SARS	NNP
cord-320331-wtxja5i9	306	30	-	-	HYPH
cord-320331-wtxja5i9	306	31	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	306	32	can	can	MD
cord-320331-wtxja5i9	306	33	more	more	RBR
cord-320331-wtxja5i9	306	34	aggressively	aggressively	RB
cord-320331-wtxja5i9	306	35	infect	infect	VB
cord-320331-wtxja5i9	306	36	the	the	DT
cord-320331-wtxja5i9	306	37	cell	cell	NN
cord-320331-wtxja5i9	306	38	,	,	,
cord-320331-wtxja5i9	306	39	by	by	IN
cord-320331-wtxja5i9	306	40	binding	bind	VBG
cord-320331-wtxja5i9	306	41	to	to	IN
cord-320331-wtxja5i9	306	42	greater	great	JJR
cord-320331-wtxja5i9	306	43	amounts	amount	NNS
cord-320331-wtxja5i9	306	44	of	of	IN
cord-320331-wtxja5i9	306	45	ACE2	ACE2	NNP
cord-320331-wtxja5i9	306	46	for	for	IN
cord-320331-wtxja5i9	306	47	viral	viral	JJ
cord-320331-wtxja5i9	306	48	entry	entry	NN
cord-320331-wtxja5i9	306	49	.	.	.
cord-320331-wtxja5i9	307	1	The	the	DT
cord-320331-wtxja5i9	307	2	concomitant	concomitant	JJ
cord-320331-wtxja5i9	307	3	immunosuppression	immunosuppression	NN
cord-320331-wtxja5i9	307	4	by	by	IN
cord-320331-wtxja5i9	307	5	NSAIDs	NSAIDs	NNP
cord-320331-wtxja5i9	307	6	also	also	RB
cord-320331-wtxja5i9	307	7	promotes	promote	VBZ
cord-320331-wtxja5i9	307	8	viral	viral	JJ
cord-320331-wtxja5i9	307	9	replication	replication	NN
cord-320331-wtxja5i9	307	10	and	and	CC
cord-320331-wtxja5i9	307	11	shedding	shedding	NN
cord-320331-wtxja5i9	307	12	of	of	IN
cord-320331-wtxja5i9	307	13	SARS	SARS	NNP
cord-320331-wtxja5i9	307	14	-	-	HYPH
cord-320331-wtxja5i9	307	15	CoV2	CoV2	NNP
cord-320331-wtxja5i9	307	16	,	,	,
cord-320331-wtxja5i9	307	17	which	which	WDT
cord-320331-wtxja5i9	307	18	can	can	MD
cord-320331-wtxja5i9	307	19	complicate	complicate	VB
cord-320331-wtxja5i9	307	20	the	the	DT
cord-320331-wtxja5i9	307	21	early	early	JJ
cord-320331-wtxja5i9	307	22	phases	phase	NNS
cord-320331-wtxja5i9	307	23	of	of	IN
cord-320331-wtxja5i9	307	24	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	307	25	.	.	.
cord-320331-wtxja5i9	308	1	Corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	308	2	can	can	MD
cord-320331-wtxja5i9	308	3	be	be	VB
cord-320331-wtxja5i9	308	4	categorized	categorize	VBN
cord-320331-wtxja5i9	308	5	into	into	IN
cord-320331-wtxja5i9	308	6	the	the	DT
cord-320331-wtxja5i9	308	7	mineralocorticoids	mineralocorticoid	NNS
cord-320331-wtxja5i9	308	8	and	and	CC
cord-320331-wtxja5i9	308	9	the	the	DT
cord-320331-wtxja5i9	308	10	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	308	11	.	.	.
cord-320331-wtxja5i9	309	1	The	the	DT
cord-320331-wtxja5i9	309	2	mineralocorticoids	mineralocorticoid	NNS
cord-320331-wtxja5i9	309	3	,	,	,
cord-320331-wtxja5i9	309	4	which	which	WDT
cord-320331-wtxja5i9	309	5	mimic	mimic	VBP
cord-320331-wtxja5i9	309	6	the	the	DT
cord-320331-wtxja5i9	309	7	actions	action	NNS
cord-320331-wtxja5i9	309	8	of	of	IN
cord-320331-wtxja5i9	309	9	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	309	10	,	,	,
cord-320331-wtxja5i9	309	11	affect	affect	VB
cord-320331-wtxja5i9	309	12	kidney	kidney	NN
cord-320331-wtxja5i9	309	13	function	function	NN
cord-320331-wtxja5i9	309	14	by	by	IN
cord-320331-wtxja5i9	309	15	increasing	increase	VBG
cord-320331-wtxja5i9	309	16	the	the	DT
cord-320331-wtxja5i9	309	17	Na	Na	NNP
cord-320331-wtxja5i9	309	18	+	+	CC
cord-320331-wtxja5i9	309	19	and	and	CC
cord-320331-wtxja5i9	309	20	H2O	h2o	NN
cord-320331-wtxja5i9	309	21	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	309	22	.	.	.
cord-320331-wtxja5i9	310	1	Because	because	IN
cord-320331-wtxja5i9	310	2	this	this	DT
cord-320331-wtxja5i9	310	3	mechanism	mechanism	NN
cord-320331-wtxja5i9	310	4	does	do	VBZ
cord-320331-wtxja5i9	310	5	not	not	RB
cord-320331-wtxja5i9	310	6	promote	promote	VB
cord-320331-wtxja5i9	310	7	Ang	Ang	NNP
cord-320331-wtxja5i9	310	8	II	II	NNP
cord-320331-wtxja5i9	310	9	formation	formation	NN
cord-320331-wtxja5i9	310	10	,	,	,
cord-320331-wtxja5i9	310	11	it	-PRON-	PRP
cord-320331-wtxja5i9	310	12	is	be	VBZ
cord-320331-wtxja5i9	310	13	not	not	RB
cord-320331-wtxja5i9	310	14	expected	expect	VBN
cord-320331-wtxja5i9	310	15	to	to	TO
cord-320331-wtxja5i9	310	16	contribute	contribute	VB
cord-320331-wtxja5i9	310	17	majorly	majorly	RB
cord-320331-wtxja5i9	310	18	to	to	IN
cord-320331-wtxja5i9	310	19	increased	increase	VBN
cord-320331-wtxja5i9	310	20	ACE2	ACE2	NNP
cord-320331-wtxja5i9	310	21	expression	expression	NN
cord-320331-wtxja5i9	310	22	.	.	.
cord-320331-wtxja5i9	311	1	On	on	IN
cord-320331-wtxja5i9	311	2	the	the	DT
cord-320331-wtxja5i9	311	3	other	other	JJ
cord-320331-wtxja5i9	311	4	hand	hand	NN
cord-320331-wtxja5i9	311	5	,	,	,
cord-320331-wtxja5i9	311	6	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	311	7	affect	affect	VBP
cord-320331-wtxja5i9	311	8	the	the	DT
cord-320331-wtxja5i9	311	9	liver	liver	NN
cord-320331-wtxja5i9	311	10	by	by	IN
cord-320331-wtxja5i9	311	11	increasing	increase	VBG
cord-320331-wtxja5i9	311	12	its	-PRON-	PRP$
cord-320331-wtxja5i9	311	13	capacity	capacity	NN
cord-320331-wtxja5i9	311	14	for	for	IN
cord-320331-wtxja5i9	311	15	gluconeogenesis	gluconeogenesis	NN
cord-320331-wtxja5i9	311	16	.	.	.
cord-320331-wtxja5i9	312	1	Muscles	muscle	NNS
cord-320331-wtxja5i9	312	2	enhance	enhance	VBP
cord-320331-wtxja5i9	312	3	protein	protein	NN
cord-320331-wtxja5i9	312	4	breakdown	breakdown	NN
cord-320331-wtxja5i9	312	5	into	into	IN
cord-320331-wtxja5i9	312	6	amino	amino	JJ
cord-320331-wtxja5i9	312	7	acids	acid	NNS
cord-320331-wtxja5i9	312	8	,	,	,
cord-320331-wtxja5i9	312	9	which	which	WDT
cord-320331-wtxja5i9	312	10	are	be	VBP
cord-320331-wtxja5i9	312	11	carried	carry	VBN
cord-320331-wtxja5i9	312	12	to	to	IN
cord-320331-wtxja5i9	312	13	the	the	DT
cord-320331-wtxja5i9	312	14	liver	liver	NN
cord-320331-wtxja5i9	312	15	for	for	IN
cord-320331-wtxja5i9	312	16	conversion	conversion	NN
cord-320331-wtxja5i9	312	17	into	into	IN
cord-320331-wtxja5i9	312	18	glucose	glucose	NN
cord-320331-wtxja5i9	312	19	.	.	.
cord-320331-wtxja5i9	313	1	Further	further	RB
cord-320331-wtxja5i9	313	2	,	,	,
cord-320331-wtxja5i9	313	3	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	313	4	promote	promote	VBP
cord-320331-wtxja5i9	313	5	the	the	DT
cord-320331-wtxja5i9	313	6	actions	action	NNS
cord-320331-wtxja5i9	313	7	of	of	IN
cord-320331-wtxja5i9	313	8	glycogen	glycogen	NN
cord-320331-wtxja5i9	313	9	,	,	,
cord-320331-wtxja5i9	313	10	and	and	CC
cord-320331-wtxja5i9	313	11	inhibit	inhibit	VB
cord-320331-wtxja5i9	313	12	the	the	DT
cord-320331-wtxja5i9	313	13	actions	action	NNS
cord-320331-wtxja5i9	313	14	of	of	IN
cord-320331-wtxja5i9	313	15	insulin	insulin	NN
cord-320331-wtxja5i9	313	16	.	.	.
cord-320331-wtxja5i9	314	1	This	this	DT
cord-320331-wtxja5i9	314	2	gluconeogenic	gluconeogenic	JJ
cord-320331-wtxja5i9	314	3	action	action	NN
cord-320331-wtxja5i9	314	4	coupled	couple	VBN
cord-320331-wtxja5i9	314	5	with	with	IN
cord-320331-wtxja5i9	314	6	insulin	insulin	NN
cord-320331-wtxja5i9	314	7	resistance	resistance	NN
cord-320331-wtxja5i9	314	8	leads	lead	VBZ
cord-320331-wtxja5i9	314	9	to	to	IN
cord-320331-wtxja5i9	314	10	hyperglycemia	hyperglycemia	NN
cord-320331-wtxja5i9	314	11	in	in	IN
cord-320331-wtxja5i9	314	12	susceptible	susceptible	JJ
cord-320331-wtxja5i9	314	13	persons	person	NNS
cord-320331-wtxja5i9	314	14	,	,	,
cord-320331-wtxja5i9	314	15	which	which	WDT
cord-320331-wtxja5i9	314	16	result	result	VBP
cord-320331-wtxja5i9	314	17	in	in	IN
cord-320331-wtxja5i9	314	18	osmotic	osmotic	JJ
cord-320331-wtxja5i9	314	19	diuresis	diuresis	NN
cord-320331-wtxja5i9	314	20	that	that	WDT
cord-320331-wtxja5i9	314	21	can	can	MD
cord-320331-wtxja5i9	314	22	substantially	substantially	RB
cord-320331-wtxja5i9	314	23	reduce	reduce	VB
cord-320331-wtxja5i9	314	24	plasma	plasma	NN
cord-320331-wtxja5i9	314	25	volume	volume	NN
cord-320331-wtxja5i9	314	26	.	.	.
cord-320331-wtxja5i9	315	1	The	the	DT
cord-320331-wtxja5i9	315	2	body	body	NN
cord-320331-wtxja5i9	315	3	compensates	compensate	VBZ
cord-320331-wtxja5i9	315	4	by	by	IN
cord-320331-wtxja5i9	315	5	upregulating	upregulate	VBG
cord-320331-wtxja5i9	315	6	ACE	ACE	NNP
cord-320331-wtxja5i9	315	7	to	to	TO
cord-320331-wtxja5i9	315	8	increase	increase	VB
cord-320331-wtxja5i9	315	9	Ang	Ang	NNP
cord-320331-wtxja5i9	315	10	II	II	NNP
cord-320331-wtxja5i9	315	11	levels	level	NNS
cord-320331-wtxja5i9	315	12	,	,	,
cord-320331-wtxja5i9	315	13	thereby	thereby	RB
cord-320331-wtxja5i9	315	14	increasing	increase	VBG
cord-320331-wtxja5i9	315	15	Na	Na	NNP
cord-320331-wtxja5i9	315	16	+	+	CC
cord-320331-wtxja5i9	315	17	and	and	CC
cord-320331-wtxja5i9	315	18	H2O	h2o	NN
cord-320331-wtxja5i9	315	19	reabsorption	reabsorption	NN
cord-320331-wtxja5i9	315	20	and	and	CC
cord-320331-wtxja5i9	315	21	vasoconstricting	vasoconstricte	VBG
cord-320331-wtxja5i9	315	22	blood	blood	NN
cord-320331-wtxja5i9	315	23	vessels	vessel	NNS
cord-320331-wtxja5i9	315	24	.	.	.
cord-320331-wtxja5i9	316	1	An	an	DT
cord-320331-wtxja5i9	316	2	expected	expect	VBN
cord-320331-wtxja5i9	316	3	increase	increase	NN
cord-320331-wtxja5i9	316	4	in	in	IN
cord-320331-wtxja5i9	316	5	ACE2	ACE2	NNP
cord-320331-wtxja5i9	316	6	to	to	TO
cord-320331-wtxja5i9	316	7	counteract	counteract	VB
cord-320331-wtxja5i9	316	8	increased	increase	VBN
cord-320331-wtxja5i9	316	9	Ang	Ang	NNP
cord-320331-wtxja5i9	316	10	II	II	NNP
cord-320331-wtxja5i9	316	11	action	action	NN
cord-320331-wtxja5i9	316	12	is	be	VBZ
cord-320331-wtxja5i9	316	13	proposed	propose	VBN
cord-320331-wtxja5i9	316	14	to	to	TO
cord-320331-wtxja5i9	316	15	be	be	VB
cord-320331-wtxja5i9	316	16	the	the	DT
cord-320331-wtxja5i9	316	17	mechanism	mechanism	NN
cord-320331-wtxja5i9	316	18	of	of	IN
cord-320331-wtxja5i9	316	19	how	how	WRB
cord-320331-wtxja5i9	316	20	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	316	21	,	,	,
cord-320331-wtxja5i9	316	22	precisely	precisely	RB
cord-320331-wtxja5i9	316	23	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	316	24	,	,	,
cord-320331-wtxja5i9	316	25	can	can	MD
cord-320331-wtxja5i9	316	26	facilitate	facilitate	VB
cord-320331-wtxja5i9	316	27	ACE2-mediated	ace2-mediate	VBN
cord-320331-wtxja5i9	316	28	SARS	SARS	NNP
cord-320331-wtxja5i9	316	29	-	-	HYPH
cord-320331-wtxja5i9	316	30	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	316	31	entry	entry	NN
cord-320331-wtxja5i9	316	32	to	to	IN
cord-320331-wtxja5i9	316	33	cells	cell	NNS
cord-320331-wtxja5i9	316	34	and	and	CC
cord-320331-wtxja5i9	316	35	viral	viral	JJ
cord-320331-wtxja5i9	316	36	replication	replication	NN
cord-320331-wtxja5i9	316	37	in	in	IN
cord-320331-wtxja5i9	316	38	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	316	39	.	.	.
cord-320331-wtxja5i9	317	1	The	the	DT
cord-320331-wtxja5i9	317	2	epidemiology	epidemiology	NN
cord-320331-wtxja5i9	317	3	and	and	CC
cord-320331-wtxja5i9	317	4	pathogenesis	pathogenesis	NN
cord-320331-wtxja5i9	317	5	of	of	IN
cord-320331-wtxja5i9	317	6	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	317	7	disease	disease	NN
cord-320331-wtxja5i9	317	8	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	317	9	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	317	10	Outbreak	Outbreak	NNP
cord-320331-wtxja5i9	317	11	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	317	12	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	317	13	Outbreak	Outbreak	NNP
cord-320331-wtxja5i9	317	14	,	,	,
cord-320331-wtxja5i9	317	15	United	United	NNP
cord-320331-wtxja5i9	317	16	States	States	NNP
cord-320331-wtxja5i9	317	17	Clinical	Clinical	NNP
cord-320331-wtxja5i9	317	18	course	course	NN
cord-320331-wtxja5i9	317	19	and	and	CC
cord-320331-wtxja5i9	317	20	risk	risk	NN
cord-320331-wtxja5i9	317	21	factors	factor	NNS
cord-320331-wtxja5i9	317	22	for	for	IN
cord-320331-wtxja5i9	317	23	mortality	mortality	NN
cord-320331-wtxja5i9	317	24	of	of	IN
cord-320331-wtxja5i9	317	25	adult	adult	NN
cord-320331-wtxja5i9	317	26	inpatients	inpatient	NNS
cord-320331-wtxja5i9	317	27	with	with	IN
cord-320331-wtxja5i9	317	28	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	317	29	in	in	IN
cord-320331-wtxja5i9	317	30	Wuhan	Wuhan	NNP
cord-320331-wtxja5i9	317	31	,	,	,
cord-320331-wtxja5i9	317	32	China	China	NNP
cord-320331-wtxja5i9	317	33	:	:	:
cord-320331-wtxja5i9	317	34	a	a	DT
cord-320331-wtxja5i9	317	35	retrospective	retrospective	JJ
cord-320331-wtxja5i9	317	36	cohort	cohort	NN
cord-320331-wtxja5i9	317	37	study	study	NN
cord-320331-wtxja5i9	317	38	Centers	Centers	NNPS
cord-320331-wtxja5i9	317	39	for	for	IN
cord-320331-wtxja5i9	317	40	Disease	Disease	NNP
cord-320331-wtxja5i9	317	41	Control	Control	NNP
cord-320331-wtxja5i9	317	42	and	and	CC
cord-320331-wtxja5i9	317	43	Prevention	Prevention	NNP
cord-320331-wtxja5i9	317	44	.	.	.
cord-320331-wtxja5i9	318	1	Severe	severe	JJ
cord-320331-wtxja5i9	318	2	outcomes	outcome	NNS
cord-320331-wtxja5i9	318	3	among	among	IN
cord-320331-wtxja5i9	318	4	patients	patient	NNS
cord-320331-wtxja5i9	318	5	with	with	IN
cord-320331-wtxja5i9	318	6	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	318	7	disease	disease	NN
cord-320331-wtxja5i9	318	8	2019	2019	CD
cord-320331-wtxja5i9	318	9	(	(	-LRB-
cord-320331-wtxja5i9	318	10	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	318	11	)	)	-RRB-
cord-320331-wtxja5i9	318	12	.	.	.
cord-320331-wtxja5i9	319	1	United	United	NNP
cord-320331-wtxja5i9	319	2	States	States	NNP
cord-320331-wtxja5i9	319	3	Identification	Identification	NNP
cord-320331-wtxja5i9	319	4	of	of	IN
cord-320331-wtxja5i9	319	5	a	a	DT
cord-320331-wtxja5i9	319	6	novel	novel	JJ
cord-320331-wtxja5i9	319	7	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	319	8	causing	cause	VBG
cord-320331-wtxja5i9	319	9	severe	severe	JJ
cord-320331-wtxja5i9	319	10	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	319	11	in	in	IN
cord-320331-wtxja5i9	319	12	humans	human	NNS
cord-320331-wtxja5i9	319	13	:	:	:
cord-320331-wtxja5i9	319	14	a	a	DT
cord-320331-wtxja5i9	319	15	descriptive	descriptive	JJ
cord-320331-wtxja5i9	319	16	study	study	NN
cord-320331-wtxja5i9	319	17	Genomic	genomic	JJ
cord-320331-wtxja5i9	319	18	characterisation	characterisation	NN
cord-320331-wtxja5i9	319	19	and	and	CC
cord-320331-wtxja5i9	319	20	epidemiology	epidemiology	NN
cord-320331-wtxja5i9	319	21	of	of	IN
cord-320331-wtxja5i9	319	22	2019	2019	CD
cord-320331-wtxja5i9	319	23	novel	novel	JJ
cord-320331-wtxja5i9	319	24	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	319	25	:	:	:
cord-320331-wtxja5i9	319	26	implications	implication	NNS
cord-320331-wtxja5i9	319	27	for	for	IN
cord-320331-wtxja5i9	319	28	virus	virus	NN
cord-320331-wtxja5i9	319	29	origins	origin	NNS
cord-320331-wtxja5i9	319	30	and	and	CC
cord-320331-wtxja5i9	319	31	receptor	receptor	NN
cord-320331-wtxja5i9	319	32	binding	bind	VBG
cord-320331-wtxja5i9	319	33	Genomic	genomic	JJ
cord-320331-wtxja5i9	319	34	characterization	characterization	NN
cord-320331-wtxja5i9	319	35	of	of	IN
cord-320331-wtxja5i9	319	36	the	the	DT
cord-320331-wtxja5i9	319	37	2019	2019	CD
cord-320331-wtxja5i9	319	38	novel	novel	NN
cord-320331-wtxja5i9	319	39	human	human	NN
cord-320331-wtxja5i9	319	40	-	-	HYPH
cord-320331-wtxja5i9	319	41	pathogenic	pathogenic	JJ
cord-320331-wtxja5i9	319	42	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	319	43	isolated	isolate	VBN
cord-320331-wtxja5i9	319	44	from	from	IN
cord-320331-wtxja5i9	319	45	a	a	DT
cord-320331-wtxja5i9	319	46	patient	patient	NN
cord-320331-wtxja5i9	319	47	with	with	IN
cord-320331-wtxja5i9	319	48	atypical	atypical	JJ
cord-320331-wtxja5i9	319	49	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	319	50	after	after	IN
cord-320331-wtxja5i9	319	51	visiting	visit	VBG
cord-320331-wtxja5i9	319	52	Wuhan	Wuhan	NNP
cord-320331-wtxja5i9	320	1	Can	Can	MD
cord-320331-wtxja5i9	320	2	we	-PRON-	PRP
cord-320331-wtxja5i9	320	3	contain	contain	VB
cord-320331-wtxja5i9	320	4	the	the	DT
cord-320331-wtxja5i9	320	5	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	320	6	outbreak	outbreak	NN
cord-320331-wtxja5i9	320	7	with	with	IN
cord-320331-wtxja5i9	320	8	the	the	DT
cord-320331-wtxja5i9	320	9	same	same	JJ
cord-320331-wtxja5i9	320	10	measures	measure	NNS
cord-320331-wtxja5i9	320	11	as	as	IN
cord-320331-wtxja5i9	320	12	for	for	IN
cord-320331-wtxja5i9	320	13	SARS	SARS	NNP
cord-320331-wtxja5i9	320	14	?	?	.
cord-320331-wtxja5i9	321	1	Evidence	evidence	NN
cord-320331-wtxja5i9	321	2	of	of	IN
cord-320331-wtxja5i9	321	3	the	the	DT
cord-320331-wtxja5i9	321	4	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	321	5	virus	virus	NN
cord-320331-wtxja5i9	321	6	targeting	target	VBG
cord-320331-wtxja5i9	321	7	the	the	DT
cord-320331-wtxja5i9	321	8	CNS	CNS	NNP
cord-320331-wtxja5i9	321	9	:	:	:
cord-320331-wtxja5i9	321	10	Tissue	tissue	NN
cord-320331-wtxja5i9	321	11	distribution	distribution	NN
cord-320331-wtxja5i9	321	12	,	,	,
cord-320331-wtxja5i9	321	13	host	host	NN
cord-320331-wtxja5i9	321	14	-	-	HYPH
cord-320331-wtxja5i9	321	15	virus	virus	NN
cord-320331-wtxja5i9	321	16	interaction	interaction	NN
cord-320331-wtxja5i9	321	17	,	,	,
cord-320331-wtxja5i9	321	18	and	and	CC
cord-320331-wtxja5i9	321	19	proposed	propose	VBD
cord-320331-wtxja5i9	321	20	neurotropic	neurotropic	NNP
cord-320331-wtxja5i9	321	21	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	322	1	The	the	DT
cord-320331-wtxja5i9	322	2	proximal	proximal	JJ
cord-320331-wtxja5i9	322	3	origin	origin	NN
cord-320331-wtxja5i9	322	4	of	of	IN
cord-320331-wtxja5i9	322	5	SARS	SARS	NNP
cord-320331-wtxja5i9	322	6	-	-	HYPH
cord-320331-wtxja5i9	322	7	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	323	1	An	an	DT
cord-320331-wtxja5i9	323	2	Overview	Overview	NNP
cord-320331-wtxja5i9	323	3	of	of	IN
cord-320331-wtxja5i9	323	4	Their	-PRON-	PRP$
cord-320331-wtxja5i9	323	5	Replication	Replication	NNP
cord-320331-wtxja5i9	323	6	and	and	CC
cord-320331-wtxja5i9	323	7	Pathogenesis	Pathogenesis	NNP
cord-320331-wtxja5i9	323	8	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	323	9	-	-	HYPH
cord-320331-wtxja5i9	323	10	converting	convert	VBG
cord-320331-wtxja5i9	323	11	enzyme	enzyme	NN
cord-320331-wtxja5i9	323	12	2	2	CD
cord-320331-wtxja5i9	323	13	(	(	-LRB-
cord-320331-wtxja5i9	323	14	ACE2	ACE2	NNP
cord-320331-wtxja5i9	323	15	)	)	-RRB-
cord-320331-wtxja5i9	323	16	is	be	VBZ
cord-320331-wtxja5i9	323	17	a	a	DT
cord-320331-wtxja5i9	323	18	key	key	JJ
cord-320331-wtxja5i9	323	19	modulator	modulator	NN
cord-320331-wtxja5i9	323	20	of	of	IN
cord-320331-wtxja5i9	323	21	the	the	DT
cord-320331-wtxja5i9	323	22	renin	renin	NN
cord-320331-wtxja5i9	323	23	angiotensin	angiotensin	NNP
cord-320331-wtxja5i9	323	24	system	system	NN
cord-320331-wtxja5i9	323	25	in	in	IN
cord-320331-wtxja5i9	323	26	health	health	NN
cord-320331-wtxja5i9	323	27	and	and	CC
cord-320331-wtxja5i9	323	28	disease	disease	NN
cord-320331-wtxja5i9	323	29	Physiology	Physiology	NNP
cord-320331-wtxja5i9	323	30	,	,	,
cord-320331-wtxja5i9	324	1	renin	renin	NNP
cord-320331-wtxja5i9	324	2	angiotensin	angiotensin	NNP
cord-320331-wtxja5i9	324	3	system	system	NN
cord-320331-wtxja5i9	324	4	Priming	Priming	NNP
cord-320331-wtxja5i9	324	5	time	time	NN
cord-320331-wtxja5i9	324	6	:	:	:
cord-320331-wtxja5i9	324	7	how	how	WRB
cord-320331-wtxja5i9	324	8	cellular	cellular	JJ
cord-320331-wtxja5i9	324	9	proteases	protease	NNS
cord-320331-wtxja5i9	324	10	arm	arm	VBP
cord-320331-wtxja5i9	324	11	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	324	12	spike	spike	NN
cord-320331-wtxja5i9	324	13	proteins	protein	NNS
cord-320331-wtxja5i9	324	14	,	,	,
cord-320331-wtxja5i9	324	15	in	in	IN
cord-320331-wtxja5i9	324	16	:	:	:
cord-320331-wtxja5i9	324	17	Activation	activation	NN
cord-320331-wtxja5i9	324	18	of	of	IN
cord-320331-wtxja5i9	324	19	Viruses	Viruses	NNPS
cord-320331-wtxja5i9	324	20	by	by	IN
cord-320331-wtxja5i9	324	21	Host	Host	NNP
cord-320331-wtxja5i9	324	22	Proteases	Proteases	NNP
cord-320331-wtxja5i9	324	23	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	324	24	cell	cell	NN
cord-320331-wtxja5i9	324	25	entry	entry	NN
cord-320331-wtxja5i9	324	26	occurs	occur	VBZ
cord-320331-wtxja5i9	324	27	through	through	IN
cord-320331-wtxja5i9	324	28	the	the	DT
cord-320331-wtxja5i9	324	29	endo-/lysosomal	endo-/lysosomal	JJ
cord-320331-wtxja5i9	324	30	pathway	pathway	NN
cord-320331-wtxja5i9	324	31	in	in	IN
cord-320331-wtxja5i9	324	32	a	a	DT
cord-320331-wtxja5i9	324	33	proteolysis	proteolysis	NN
cord-320331-wtxja5i9	324	34	-	-	HYPH
cord-320331-wtxja5i9	324	35	dependent	dependent	JJ
cord-320331-wtxja5i9	324	36	manner	manner	NN
cord-320331-wtxja5i9	325	1	The	the	DT
cord-320331-wtxja5i9	325	2	protective	protective	JJ
cord-320331-wtxja5i9	325	3	arm	arm	NN
cord-320331-wtxja5i9	325	4	of	of	IN
cord-320331-wtxja5i9	325	5	the	the	DT
cord-320331-wtxja5i9	325	6	renin	renin	NN
cord-320331-wtxja5i9	325	7	angiotensin	angiotensin	NNP
cord-320331-wtxja5i9	325	8	system	system	NN
cord-320331-wtxja5i9	325	9	:	:	:
cord-320331-wtxja5i9	325	10	Functional	functional	JJ
cord-320331-wtxja5i9	325	11	aspects	aspect	NNS
cord-320331-wtxja5i9	325	12	and	and	CC
cord-320331-wtxja5i9	325	13	therapeutic	therapeutic	JJ
cord-320331-wtxja5i9	325	14	implications	implication	NNS
cord-320331-wtxja5i9	326	1	Are	be	VBP
cord-320331-wtxja5i9	326	2	patients	patient	NNS
cord-320331-wtxja5i9	326	3	with	with	IN
cord-320331-wtxja5i9	326	4	hypertension	hypertension	NN
cord-320331-wtxja5i9	326	5	and	and	CC
cord-320331-wtxja5i9	326	6	diabetes	diabetes	NN
cord-320331-wtxja5i9	326	7	mellitus	mellitus	NN
cord-320331-wtxja5i9	326	8	at	at	IN
cord-320331-wtxja5i9	326	9	increased	increase	VBN
cord-320331-wtxja5i9	326	10	risk	risk	NN
cord-320331-wtxja5i9	326	11	for	for	IN
cord-320331-wtxja5i9	326	12	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	326	13	infection	infection	NN
cord-320331-wtxja5i9	326	14	?	?	.
cord-320331-wtxja5i9	327	1	21	21	CD
cord-320331-wtxja5i9	328	1	--Neuromuscular	--Neuromuscular	VBZ
cord-320331-wtxja5i9	328	2	physiology	physiology	NN
cord-320331-wtxja5i9	328	3	and	and	CC
cord-320331-wtxja5i9	328	4	pharmacology	pharmacology	NN
cord-320331-wtxja5i9	328	5	Effect	Effect	NNP
cord-320331-wtxja5i9	328	6	of	of	IN
cord-320331-wtxja5i9	328	7	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	328	8	-	-	HYPH
cord-320331-wtxja5i9	328	9	converting	convert	VBG
cord-320331-wtxja5i9	328	10	enzyme	enzyme	NN
cord-320331-wtxja5i9	328	11	inhibition	inhibition	NN
cord-320331-wtxja5i9	328	12	and	and	CC
cord-320331-wtxja5i9	328	13	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	328	14	II	ii	CD
cord-320331-wtxja5i9	328	15	receptor	receptor	NN
cord-320331-wtxja5i9	328	16	blockers	blocker	NNS
cord-320331-wtxja5i9	328	17	on	on	IN
cord-320331-wtxja5i9	328	18	cardiac	cardiac	JJ
cord-320331-wtxja5i9	328	19	angiotensinconverting	angiotensinconverting	NN
cord-320331-wtxja5i9	328	20	enzyme	enzyme	NN
cord-320331-wtxja5i9	328	21	2	2	CD
cord-320331-wtxja5i9	328	22	Upregulation	Upregulation	NNP
cord-320331-wtxja5i9	328	23	of	of	IN
cord-320331-wtxja5i9	328	24	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	328	25	-	-	HYPH
cord-320331-wtxja5i9	328	26	converting	convert	VBG
cord-320331-wtxja5i9	328	27	enzyme	enzyme	NN
cord-320331-wtxja5i9	328	28	(	(	-LRB-
cord-320331-wtxja5i9	328	29	ACE	ace	NN
cord-320331-wtxja5i9	328	30	)	)	-RRB-
cord-320331-wtxja5i9	328	31	2	2	CD
cord-320331-wtxja5i9	328	32	in	in	IN
cord-320331-wtxja5i9	328	33	hepatic	hepatic	JJ
cord-320331-wtxja5i9	328	34	fibrosis	fibrosis	NN
cord-320331-wtxja5i9	328	35	by	by	IN
cord-320331-wtxja5i9	328	36	ACE	ACE	NNP
cord-320331-wtxja5i9	328	37	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	329	1	Increased	increase	VBN
cord-320331-wtxja5i9	329	2	expression	expression	NN
cord-320331-wtxja5i9	329	3	of	of	IN
cord-320331-wtxja5i9	329	4	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	329	5	converting	convert	VBG
cord-320331-wtxja5i9	329	6	Regulation	Regulation	NNP
cord-320331-wtxja5i9	329	7	of	of	IN
cord-320331-wtxja5i9	329	8	ACE2	ACE2	NNP
cord-320331-wtxja5i9	329	9	in	in	IN
cord-320331-wtxja5i9	329	10	cardiac	cardiac	JJ
cord-320331-wtxja5i9	329	11	myocytes	myocyte	NNS
cord-320331-wtxja5i9	329	12	and	and	CC
cord-320331-wtxja5i9	329	13	fibroblasts	fibroblast	NNS
cord-320331-wtxja5i9	329	14	Updated	update	VBN
cord-320331-wtxja5i9	330	1	:	:	:
cord-320331-wtxja5i9	330	2	WHO	who	WP
cord-320331-wtxja5i9	330	3	now	now	RB
cord-320331-wtxja5i9	330	4	does	do	VBZ
cord-320331-wtxja5i9	330	5	n't	not	RB
cord-320331-wtxja5i9	330	6	recommend	recommend	VB
cord-320331-wtxja5i9	330	7	avoiding	avoid	VBG
cord-320331-wtxja5i9	330	8	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	330	9	For	for	IN
cord-320331-wtxja5i9	330	10	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	330	11	symptoms	symptom	NNS
cord-320331-wtxja5i9	330	12	Covid-19	covid-19	VBP
cord-320331-wtxja5i9	330	13	:	:	:
cord-320331-wtxja5i9	330	14	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	330	15	should	should	MD
cord-320331-wtxja5i9	330	16	not	not	RB
cord-320331-wtxja5i9	330	17	be	be	VB
cord-320331-wtxja5i9	330	18	used	use	VBN
cord-320331-wtxja5i9	330	19	for	for	IN
cord-320331-wtxja5i9	330	20	managing	manage	VBG
cord-320331-wtxja5i9	330	21	symptoms	symptom	NNS
cord-320331-wtxja5i9	330	22	,	,	,
cord-320331-wtxja5i9	330	23	say	say	VBP
cord-320331-wtxja5i9	330	24	doctors	doctor	NNS
cord-320331-wtxja5i9	330	25	and	and	CC
cord-320331-wtxja5i9	330	26	scientists	scientist	NNS
cord-320331-wtxja5i9	330	27	Paracetamol	Paracetamol	NNP
cord-320331-wtxja5i9	330	28	:	:	:
cord-320331-wtxja5i9	330	29	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	330	30	and	and	CC
cord-320331-wtxja5i9	330	31	updates	update	NNS
cord-320331-wtxja5i9	330	32	.	.	.
cord-320331-wtxja5i9	331	1	Continuing	continue	VBG
cord-320331-wtxja5i9	331	2	Education	Education	NNP
cord-320331-wtxja5i9	331	3	in	in	IN
cord-320331-wtxja5i9	331	4	Anaesthesia	Anaesthesia	NNP
cord-320331-wtxja5i9	331	5	Critical	Critical	NNP
cord-320331-wtxja5i9	331	6	Care	Care	NNP
cord-320331-wtxja5i9	331	7	&	&	CC
cord-320331-wtxja5i9	331	8	antipyretic	antipyretic	JJ
cord-320331-wtxja5i9	331	9	drugs	drug	NNS
cord-320331-wtxja5i9	331	10	:	:	:
cord-320331-wtxja5i9	331	11	Cloning	cloning	NN
cord-320331-wtxja5i9	331	12	,	,	,
cord-320331-wtxja5i9	331	13	structure	structure	NN
cord-320331-wtxja5i9	331	14	,	,	,
cord-320331-wtxja5i9	331	15	and	and	CC
cord-320331-wtxja5i9	331	16	expression	expression	NN
cord-320331-wtxja5i9	331	17	StatPearls	StatPearls	NNP
cord-320331-wtxja5i9	331	18	.	.	.
cord-320331-wtxja5i9	332	1	Treasure	Treasure	NNP
cord-320331-wtxja5i9	332	2	Island	Island	NNP
cord-320331-wtxja5i9	332	3	(	(	-LRB-
cord-320331-wtxja5i9	332	4	FL	FL	NNP
cord-320331-wtxja5i9	332	5	)	)	-RRB-
cord-320331-wtxja5i9	332	6	Effects	effect	NNS
cord-320331-wtxja5i9	332	7	of	of	IN
cord-320331-wtxja5i9	332	8	acetaminophen	acetaminophen	NN
cord-320331-wtxja5i9	332	9	on	on	IN
cord-320331-wtxja5i9	332	10	morphine	morphine	NN
cord-320331-wtxja5i9	332	11	side	side	NN
cord-320331-wtxja5i9	332	12	-	-	HYPH
cord-320331-wtxja5i9	332	13	effects	effect	NNS
cord-320331-wtxja5i9	332	14	and	and	CC
cord-320331-wtxja5i9	332	15	consumption	consumption	NN
cord-320331-wtxja5i9	332	16	after	after	IN
cord-320331-wtxja5i9	332	17	major	major	JJ
cord-320331-wtxja5i9	332	18	surgery	surgery	NN
cord-320331-wtxja5i9	332	19	:	:	:
cord-320331-wtxja5i9	332	20	meta	meta	NN
cord-320331-wtxja5i9	332	21	-	-	HYPH
cord-320331-wtxja5i9	332	22	analysis	analysis	NN
cord-320331-wtxja5i9	332	23	of	of	IN
cord-320331-wtxja5i9	332	24	randomized	randomized	JJ
cord-320331-wtxja5i9	332	25	controlled	control	VBN
cord-320331-wtxja5i9	332	26	trials	trial	NNS
cord-320331-wtxja5i9	333	1	An	an	DT
cord-320331-wtxja5i9	333	2	overview	overview	NN
cord-320331-wtxja5i9	333	3	of	of	IN
cord-320331-wtxja5i9	333	4	clinical	clinical	JJ
cord-320331-wtxja5i9	333	5	pharmacology	pharmacology	NN
cord-320331-wtxja5i9	333	6	of	of	IN
cord-320331-wtxja5i9	333	7	ibuprofen	ibuprofen	JJ
cord-320331-wtxja5i9	333	8	Prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	333	9	and	and	CC
cord-320331-wtxja5i9	333	10	inflammation	inflammation	NN
cord-320331-wtxja5i9	333	11	Cardioprotective	Cardioprotective	NNP
cord-320331-wtxja5i9	333	12	role	role	NN
cord-320331-wtxja5i9	333	13	for	for	IN
cord-320331-wtxja5i9	333	14	angiotensin-(1	angiotensin-(1	CD
cord-320331-wtxja5i9	333	15	-	-	SYM
cord-320331-wtxja5i9	333	16	7	7	CD
cord-320331-wtxja5i9	333	17	)	)	-RRB-
cord-320331-wtxja5i9	333	18	and	and	CC
cord-320331-wtxja5i9	333	19	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	333	20	converting	convert	VBG
cord-320331-wtxja5i9	333	21	enzyme	enzyme	NN
cord-320331-wtxja5i9	333	22	2	2	CD
cord-320331-wtxja5i9	333	23	in	in	IN
cord-320331-wtxja5i9	333	24	the	the	DT
cord-320331-wtxja5i9	333	25	heart	heart	NN
cord-320331-wtxja5i9	333	26	ACE	ACE	NNP
cord-320331-wtxja5i9	333	27	and	and	CC
cord-320331-wtxja5i9	333	28	ACE2	ACE2	NNP
cord-320331-wtxja5i9	333	29	in	in	IN
cord-320331-wtxja5i9	333	30	kidney	kidney	NN
cord-320331-wtxja5i9	333	31	disease	disease	NN
cord-320331-wtxja5i9	333	32	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	333	33	-	-	HYPH
cord-320331-wtxja5i9	333	34	converting	convert	VBG
cord-320331-wtxja5i9	333	35	enzyme	enzyme	NN
cord-320331-wtxja5i9	333	36	2	2	CD
cord-320331-wtxja5i9	333	37	in	in	IN
cord-320331-wtxja5i9	333	38	lung	lung	NN
cord-320331-wtxja5i9	333	39	diseases	disease	NNS
cord-320331-wtxja5i9	334	1	Dysregulated	Dysregulated	NNP
cord-320331-wtxja5i9	334	2	renin	renin	NN
cord-320331-wtxja5i9	334	3	-	-	HYPH
cord-320331-wtxja5i9	334	4	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	334	5	-	-	HYPH
cord-320331-wtxja5i9	334	6	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	334	7	system	system	NN
cord-320331-wtxja5i9	334	8	contributes	contribute	VBZ
cord-320331-wtxja5i9	334	9	to	to	IN
cord-320331-wtxja5i9	334	10	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	334	11	arterial	arterial	JJ
cord-320331-wtxja5i9	334	12	hypertension	hypertension	NN
cord-320331-wtxja5i9	335	1	The	the	DT
cord-320331-wtxja5i9	335	2	renin	renin	NN
cord-320331-wtxja5i9	335	3	-	-	HYPH
cord-320331-wtxja5i9	335	4	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	335	5	system	system	NN
cord-320331-wtxja5i9	335	6	in	in	IN
cord-320331-wtxja5i9	335	7	pulmonary	pulmonary	JJ
cord-320331-wtxja5i9	335	8	hypertension	hypertension	NN
cord-320331-wtxja5i9	336	1	Diminished	Diminished	NNP
cord-320331-wtxja5i9	336	2	COX-2	COX-2	NNP
cord-320331-wtxja5i9	336	3	/	/	SYM
cord-320331-wtxja5i9	336	4	PGE2-mediated	pge2-mediated	JJ
cord-320331-wtxja5i9	336	5	antiviral	antiviral	JJ
cord-320331-wtxja5i9	336	6	response	response	NN
cord-320331-wtxja5i9	336	7	due	due	IN
cord-320331-wtxja5i9	336	8	to	to	IN
cord-320331-wtxja5i9	336	9	impaired	impair	VBN
cord-320331-wtxja5i9	336	10	NOX	NOX	NNP
cord-320331-wtxja5i9	336	11	/	/	SYM
cord-320331-wtxja5i9	336	12	MAPK	MAPK	NNP
cord-320331-wtxja5i9	336	13	signaling	signal	VBG
cord-320331-wtxja5i9	336	14	in	in	IN
cord-320331-wtxja5i9	336	15	G6PD	G6PD	NNP
cord-320331-wtxja5i9	336	16	-	-	HYPH
cord-320331-wtxja5i9	336	17	knockdown	knockdown	NN
cord-320331-wtxja5i9	336	18	lung	lung	NN
cord-320331-wtxja5i9	336	19	epithelial	epithelial	NN
cord-320331-wtxja5i9	336	20	cells	cell	NNS
cord-320331-wtxja5i9	336	21	Anti	anti	JJ
cord-320331-wtxja5i9	336	22	-	-	JJ
cord-320331-wtxja5i9	336	23	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	336	24	role	role	NN
cord-320331-wtxja5i9	336	25	of	of	IN
cord-320331-wtxja5i9	336	26	PGD2	PGD2	NNP
cord-320331-wtxja5i9	336	27	in	in	IN
cord-320331-wtxja5i9	336	28	acute	acute	JJ
cord-320331-wtxja5i9	336	29	lung	lung	NN
cord-320331-wtxja5i9	336	30	inflammation	inflammation	NN
cord-320331-wtxja5i9	336	31	and	and	CC
cord-320331-wtxja5i9	336	32	therapeutic	therapeutic	JJ
cord-320331-wtxja5i9	336	33	application	application	NN
cord-320331-wtxja5i9	336	34	of	of	IN
cord-320331-wtxja5i9	336	35	its	-PRON-	PRP$
cord-320331-wtxja5i9	336	36	signal	signal	NN
cord-320331-wtxja5i9	336	37	enhancement	enhancement	NN
cord-320331-wtxja5i9	337	1	The	the	DT
cord-320331-wtxja5i9	337	2	use	use	NN
cord-320331-wtxja5i9	337	3	of	of	IN
cord-320331-wtxja5i9	337	4	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	337	5	as	as	IN
cord-320331-wtxja5i9	337	6	treatment	treatment	NN
cord-320331-wtxja5i9	337	7	in	in	IN
cord-320331-wtxja5i9	337	8	SARS	SARS	NNP
cord-320331-wtxja5i9	337	9	was	be	VBD
cord-320331-wtxja5i9	337	10	associated	associate	VBN
cord-320331-wtxja5i9	337	11	with	with	IN
cord-320331-wtxja5i9	337	12	adverse	adverse	JJ
cord-320331-wtxja5i9	337	13	outcomes	outcome	NNS
cord-320331-wtxja5i9	337	14	:	:	:
cord-320331-wtxja5i9	337	15	a	a	DT
cord-320331-wtxja5i9	337	16	retrospective	retrospective	JJ
cord-320331-wtxja5i9	337	17	cohort	cohort	NN
cord-320331-wtxja5i9	337	18	study	study	NN
cord-320331-wtxja5i9	338	1	The	the	DT
cord-320331-wtxja5i9	338	2	kidneys	kidney	NNS
cord-320331-wtxja5i9	338	3	and	and	CC
cord-320331-wtxja5i9	338	4	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	338	5	/	/	SYM
cord-320331-wtxja5i9	338	6	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	338	7	receptor	receptor	NN
cord-320331-wtxja5i9	338	8	system	system	NN
cord-320331-wtxja5i9	338	9	in	in	IN
cord-320331-wtxja5i9	338	10	saltsensitive	saltsensitive	JJ
cord-320331-wtxja5i9	338	11	hypertension	hypertension	NN
cord-320331-wtxja5i9	339	1	How	how	WRB
cord-320331-wtxja5i9	339	2	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	339	3	control	control	VBP
cord-320331-wtxja5i9	339	4	inflammation	inflammation	NN
cord-320331-wtxja5i9	340	1	:	:	:
cord-320331-wtxja5i9	340	2	Quintiles	Quintiles	NNP
cord-320331-wtxja5i9	340	3	Prize	Prize	NNP
cord-320331-wtxja5i9	340	4	Lecture	Lecture	NNP
cord-320331-wtxja5i9	340	5	Experts	Experts	NNPS
cord-320331-wtxja5i9	340	6	question	question	VBP
cord-320331-wtxja5i9	340	7	official	official	JJ
cord-320331-wtxja5i9	340	8	NHS	NHS	NNP
cord-320331-wtxja5i9	340	9	advice	advice	NN
cord-320331-wtxja5i9	340	10	over	over	IN
cord-320331-wtxja5i9	340	11	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	340	12	and	and	CC
cord-320331-wtxja5i9	340	13	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	340	14	.	.	.
cord-320331-wtxja5i9	341	1	The	the	DT
cord-320331-wtxja5i9	341	2	Telegraph	Telegraph	NNP
cord-320331-wtxja5i9	341	3	2020	2020	CD
cord-320331-wtxja5i9	341	4	Ibuprofen	Ibuprofen	NNP
cord-320331-wtxja5i9	341	5	,	,	,
cord-320331-wtxja5i9	341	6	paracetamol	paracetamol	NN
cord-320331-wtxja5i9	341	7	,	,	,
cord-320331-wtxja5i9	341	8	and	and	CC
cord-320331-wtxja5i9	341	9	steam	steam	VB
cord-320331-wtxja5i9	341	10	for	for	IN
cord-320331-wtxja5i9	341	11	patients	patient	NNS
cord-320331-wtxja5i9	341	12	with	with	IN
cord-320331-wtxja5i9	341	13	respiratory	respiratory	JJ
cord-320331-wtxja5i9	341	14	tract	tract	NN
cord-320331-wtxja5i9	341	15	infections	infection	NNS
cord-320331-wtxja5i9	341	16	in	in	IN
cord-320331-wtxja5i9	341	17	primary	primary	JJ
cord-320331-wtxja5i9	341	18	care	care	NN
cord-320331-wtxja5i9	341	19	:	:	:
cord-320331-wtxja5i9	341	20	pragmatic	pragmatic	JJ
cord-320331-wtxja5i9	341	21	randomised	randomised	JJ
cord-320331-wtxja5i9	341	22	factorial	factorial	JJ
cord-320331-wtxja5i9	341	23	trial	trial	NN
cord-320331-wtxja5i9	341	24	Non	non	JJ
cord-320331-wtxja5i9	341	25	-	-	JJ
cord-320331-wtxja5i9	341	26	steroidal	steroidal	JJ
cord-320331-wtxja5i9	341	27	antiinflammatory	antiinflammatory	JJ
cord-320331-wtxja5i9	341	28	drugs	drug	NNS
cord-320331-wtxja5i9	341	29	may	may	MD
cord-320331-wtxja5i9	341	30	worsen	worsen	VB
cord-320331-wtxja5i9	341	31	the	the	DT
cord-320331-wtxja5i9	341	32	course	course	NN
cord-320331-wtxja5i9	341	33	of	of	IN
cord-320331-wtxja5i9	341	34	community	community	NN
cord-320331-wtxja5i9	341	35	-	-	HYPH
cord-320331-wtxja5i9	341	36	acquired	acquire	VBN
cord-320331-wtxja5i9	341	37	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	341	38	A	a	DT
cord-320331-wtxja5i9	341	39	randomized	randomized	JJ
cord-320331-wtxja5i9	341	40	placebo	placebo	NN
cord-320331-wtxja5i9	341	41	controlled	control	VBN
cord-320331-wtxja5i9	341	42	trial	trial	NN
cord-320331-wtxja5i9	341	43	of	of	IN
cord-320331-wtxja5i9	341	44	ibuprofen	ibuprofen	NN
cord-320331-wtxja5i9	341	45	for	for	IN
cord-320331-wtxja5i9	341	46	respiratory	respiratory	JJ
cord-320331-wtxja5i9	341	47	syncytial	syncytial	JJ
cord-320331-wtxja5i9	341	48	virus	virus	NN
cord-320331-wtxja5i9	341	49	infection	infection	NN
cord-320331-wtxja5i9	341	50	in	in	IN
cord-320331-wtxja5i9	341	51	a	a	DT
cord-320331-wtxja5i9	341	52	bovine	bovine	JJ
cord-320331-wtxja5i9	341	53	model	model	NN
cord-320331-wtxja5i9	341	54	Toll	toll	NN
cord-320331-wtxja5i9	341	55	-	-	HYPH
cord-320331-wtxja5i9	341	56	like	like	JJ
cord-320331-wtxja5i9	341	57	receptors	receptor	NNS
cord-320331-wtxja5i9	341	58	in	in	IN
cord-320331-wtxja5i9	341	59	antiviral	antiviral	JJ
cord-320331-wtxja5i9	341	60	innate	innate	JJ
cord-320331-wtxja5i9	341	61	immunity	immunity	NN
cord-320331-wtxja5i9	341	62	Type	type	NN
cord-320331-wtxja5i9	341	63	I	-PRON-	PRP
cord-320331-wtxja5i9	341	64	interferons	interferon	NNS
cord-320331-wtxja5i9	341	65	in	in	IN
cord-320331-wtxja5i9	341	66	viral	viral	JJ
cord-320331-wtxja5i9	341	67	control	control	NN
cord-320331-wtxja5i9	341	68	and	and	CC
cord-320331-wtxja5i9	341	69	immune	immune	JJ
cord-320331-wtxja5i9	341	70	regulation	regulation	NN
cord-320331-wtxja5i9	341	71	Mechanism	Mechanism	NNP
cord-320331-wtxja5i9	341	72	of	of	IN
cord-320331-wtxja5i9	341	73	simulation	simulation	NN
cord-320331-wtxja5i9	341	74	by	by	IN
cord-320331-wtxja5i9	341	75	human	human	JJ
cord-320331-wtxja5i9	341	76	interferon	interferon	NN
cord-320331-wtxja5i9	341	77	of	of	IN
cord-320331-wtxja5i9	341	78	prostaglandin	prostaglandin	JJ
cord-320331-wtxja5i9	341	79	synthesis	synthesis	NN
cord-320331-wtxja5i9	341	80	in	in	IN
cord-320331-wtxja5i9	341	81	human	human	JJ
cord-320331-wtxja5i9	341	82	cell	cell	NN
cord-320331-wtxja5i9	341	83	lines	line	NNS
cord-320331-wtxja5i9	342	1	The	the	DT
cord-320331-wtxja5i9	342	2	role	role	NN
cord-320331-wtxja5i9	342	3	of	of	IN
cord-320331-wtxja5i9	342	4	prostaglandins	prostaglandin	NNS
cord-320331-wtxja5i9	342	5	in	in	IN
cord-320331-wtxja5i9	342	6	the	the	DT
cord-320331-wtxja5i9	342	7	immune	immune	JJ
cord-320331-wtxja5i9	342	8	response	response	NN
cord-320331-wtxja5i9	342	9	Antiviral	antiviral	JJ
cord-320331-wtxja5i9	342	10	innate	innate	JJ
cord-320331-wtxja5i9	342	11	immune	immune	JJ
cord-320331-wtxja5i9	342	12	response	response	NN
cord-320331-wtxja5i9	342	13	interferes	interfere	VBZ
cord-320331-wtxja5i9	342	14	with	with	IN
cord-320331-wtxja5i9	342	15	the	the	DT
cord-320331-wtxja5i9	342	16	formation	formation	NN
cord-320331-wtxja5i9	342	17	of	of	IN
cord-320331-wtxja5i9	342	18	replication	replication	NN
cord-320331-wtxja5i9	342	19	-	-	HYPH
cord-320331-wtxja5i9	342	20	associated	associate	VBN
cord-320331-wtxja5i9	342	21	membrane	membrane	NN
cord-320331-wtxja5i9	342	22	structures	structure	NNS
cord-320331-wtxja5i9	342	23	induced	induce	VBN
cord-320331-wtxja5i9	342	24	by	by	IN
cord-320331-wtxja5i9	342	25	a	a	DT
cord-320331-wtxja5i9	342	26	positive	positive	JJ
cord-320331-wtxja5i9	342	27	-	-	HYPH
cord-320331-wtxja5i9	342	28	strand	strand	NN
cord-320331-wtxja5i9	342	29	RNA	RNA	NNP
cord-320331-wtxja5i9	342	30	virus	virus	NN
cord-320331-wtxja5i9	342	31	Prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	342	32	E2	E2	NNP
cord-320331-wtxja5i9	342	33	and	and	CC
cord-320331-wtxja5i9	342	34	the	the	DT
cord-320331-wtxja5i9	342	35	suppression	suppression	NN
cord-320331-wtxja5i9	342	36	of	of	IN
cord-320331-wtxja5i9	342	37	phagocyte	phagocyte	NNP
cord-320331-wtxja5i9	342	38	innate	innate	VBP
cord-320331-wtxja5i9	342	39	immune	immune	JJ
cord-320331-wtxja5i9	342	40	responses	response	NNS
cord-320331-wtxja5i9	342	41	in	in	IN
cord-320331-wtxja5i9	342	42	different	different	JJ
cord-320331-wtxja5i9	342	43	organs	organ	NNS
cord-320331-wtxja5i9	342	44	Polarization	polarization	NN
cord-320331-wtxja5i9	342	45	of	of	IN
cord-320331-wtxja5i9	342	46	the	the	DT
cord-320331-wtxja5i9	342	47	innate	innate	JJ
cord-320331-wtxja5i9	342	48	immune	immune	JJ
cord-320331-wtxja5i9	342	49	response	response	NN
cord-320331-wtxja5i9	342	50	by	by	IN
cord-320331-wtxja5i9	342	51	prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	342	52	E2	E2	NNP
cord-320331-wtxja5i9	342	53	:	:	:
cord-320331-wtxja5i9	342	54	A	a	DT
cord-320331-wtxja5i9	342	55	puzzle	puzzle	NN
cord-320331-wtxja5i9	342	56	of	of	IN
cord-320331-wtxja5i9	342	57	receptors	receptor	NNS
cord-320331-wtxja5i9	342	58	and	and	CC
cord-320331-wtxja5i9	342	59	signals	signal	NNS
cord-320331-wtxja5i9	342	60	The	the	DT
cord-320331-wtxja5i9	342	61	role	role	NN
cord-320331-wtxja5i9	342	62	and	and	CC
cord-320331-wtxja5i9	342	63	regulation	regulation	NN
cord-320331-wtxja5i9	342	64	of	of	IN
cord-320331-wtxja5i9	342	65	COX-2	COX-2	NNP
cord-320331-wtxja5i9	342	66	during	during	IN
cord-320331-wtxja5i9	342	67	viral	viral	JJ
cord-320331-wtxja5i9	342	68	infection	infection	NN
cord-320331-wtxja5i9	342	69	Prostaglandin	prostaglandin	NN
cord-320331-wtxja5i9	342	70	E2	E2	NNP
cord-320331-wtxja5i9	342	71	as	as	IN
cord-320331-wtxja5i9	342	72	a	a	DT
cord-320331-wtxja5i9	342	73	modulator	modulator	NN
cord-320331-wtxja5i9	342	74	of	of	IN
cord-320331-wtxja5i9	342	75	viral	viral	JJ
cord-320331-wtxja5i9	342	76	infections	infection	NNS
cord-320331-wtxja5i9	343	1	The	the	DT
cord-320331-wtxja5i9	343	2	evolving	evolve	VBG
cord-320331-wtxja5i9	343	3	role	role	NN
cord-320331-wtxja5i9	343	4	of	of	IN
cord-320331-wtxja5i9	343	5	the	the	DT
cord-320331-wtxja5i9	343	6	reninangiotensin	reninangiotensin	JJ
cord-320331-wtxja5i9	343	7	system	system	NN
cord-320331-wtxja5i9	343	8	in	in	IN
cord-320331-wtxja5i9	343	9	ARDS	ARDS	NNP
cord-320331-wtxja5i9	344	1	The	the	DT
cord-320331-wtxja5i9	344	2	role	role	NN
cord-320331-wtxja5i9	344	3	of	of	IN
cord-320331-wtxja5i9	344	4	the	the	DT
cord-320331-wtxja5i9	344	5	renin	renin	NN
cord-320331-wtxja5i9	344	6	-	-	HYPH
cord-320331-wtxja5i9	344	7	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	344	8	system	system	NN
cord-320331-wtxja5i9	344	9	in	in	IN
cord-320331-wtxja5i9	344	10	severe	severe	JJ
cord-320331-wtxja5i9	344	11	acute	acute	JJ
cord-320331-wtxja5i9	344	12	respiratory	respiratory	JJ
cord-320331-wtxja5i9	344	13	syndrome	syndrome	NN
cord-320331-wtxja5i9	344	14	-	-	:
cord-320331-wtxja5i9	344	15	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	344	16	infection	infection	NN
cord-320331-wtxja5i9	344	17	COVID-19	covid-19	VBP
cord-320331-wtxja5i9	344	18	and	and	CC
cord-320331-wtxja5i9	344	19	the	the	DT
cord-320331-wtxja5i9	344	20	resulting	result	VBG
cord-320331-wtxja5i9	344	21	ARDS	ARDS	NNP
cord-320331-wtxja5i9	344	22	A	a	DT
cord-320331-wtxja5i9	344	23	multibasic	multibasic	NN
cord-320331-wtxja5i9	344	24	cleavage	cleavage	NN
cord-320331-wtxja5i9	344	25	site	site	NN
cord-320331-wtxja5i9	344	26	in	in	IN
cord-320331-wtxja5i9	344	27	the	the	DT
cord-320331-wtxja5i9	344	28	spike	spike	NN
cord-320331-wtxja5i9	344	29	protein	protein	NN
cord-320331-wtxja5i9	344	30	of	of	IN
cord-320331-wtxja5i9	344	31	SARS	SARS	NNP
cord-320331-wtxja5i9	344	32	-	-	HYPH
cord-320331-wtxja5i9	344	33	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	345	1	is	be	VBZ
cord-320331-wtxja5i9	345	2	essential	essential	JJ
cord-320331-wtxja5i9	345	3	for	for	IN
cord-320331-wtxja5i9	345	4	infection	infection	NN
cord-320331-wtxja5i9	345	5	of	of	IN
cord-320331-wtxja5i9	345	6	human	human	JJ
cord-320331-wtxja5i9	345	7	lung	lung	NN
cord-320331-wtxja5i9	345	8	cells	cell	NNS
cord-320331-wtxja5i9	345	9	Ganging	gang	VBG
cord-320331-wtxja5i9	345	10	up	up	RP
cord-320331-wtxja5i9	345	11	on	on	IN
cord-320331-wtxja5i9	345	12	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	345	13	II	ii	CD
cord-320331-wtxja5i9	345	14	type	type	NN
cord-320331-wtxja5i9	345	15	1	1	CD
cord-320331-wtxja5i9	345	16	receptors	receptor	NNS
cord-320331-wtxja5i9	345	17	in	in	IN
cord-320331-wtxja5i9	345	18	vascular	vascular	JJ
cord-320331-wtxja5i9	345	19	remodeling	remodel	VBG
cord-320331-wtxja5i9	345	20	Low	low	JJ
cord-320331-wtxja5i9	345	21	-	-	HYPH
cord-320331-wtxja5i9	345	22	cost	cost	NN
cord-320331-wtxja5i9	345	23	dexamethasone	dexamethasone	NN
cord-320331-wtxja5i9	345	24	reduces	reduce	VBZ
cord-320331-wtxja5i9	345	25	death	death	NN
cord-320331-wtxja5i9	345	26	by	by	IN
cord-320331-wtxja5i9	345	27	up	up	IN
cord-320331-wtxja5i9	345	28	to	to	TO
cord-320331-wtxja5i9	345	29	one	one	CD
cord-320331-wtxja5i9	345	30	third	third	NN
cord-320331-wtxja5i9	345	31	in	in	IN
cord-320331-wtxja5i9	345	32	hospitalised	hospitalise	VBN
cord-320331-wtxja5i9	345	33	patients	patient	NNS
cord-320331-wtxja5i9	345	34	with	with	IN
cord-320331-wtxja5i9	345	35	severe	severe	JJ
cord-320331-wtxja5i9	345	36	respiratory	respiratory	JJ
cord-320331-wtxja5i9	345	37	complications	complication	NNS
cord-320331-wtxja5i9	345	38	of	of	IN
cord-320331-wtxja5i9	345	39	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	345	40	.	.	.
cord-320331-wtxja5i9	346	1	RECOVERY	recovery	NN
cord-320331-wtxja5i9	346	2	trial	trial	NN
cord-320331-wtxja5i9	346	3	2020	2020	CD
cord-320331-wtxja5i9	347	1	Inhaled	inhale	VBN
cord-320331-wtxja5i9	347	2	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	347	3	and	and	CC
cord-320331-wtxja5i9	347	4	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	347	5	:	:	:
cord-320331-wtxja5i9	347	6	a	a	DT
cord-320331-wtxja5i9	347	7	systematic	systematic	JJ
cord-320331-wtxja5i9	347	8	review	review	NN
cord-320331-wtxja5i9	347	9	and	and	CC
cord-320331-wtxja5i9	347	10	clinical	clinical	JJ
cord-320331-wtxja5i9	347	11	perspective	perspective	NN
cord-320331-wtxja5i9	347	12	Severe	severe	JJ
cord-320331-wtxja5i9	347	13	outcomes	outcome	NNS
cord-320331-wtxja5i9	347	14	among	among	IN
cord-320331-wtxja5i9	347	15	patients	patient	NNS
cord-320331-wtxja5i9	347	16	with	with	IN
cord-320331-wtxja5i9	347	17	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	347	18	disease	disease	NN
cord-320331-wtxja5i9	347	19	2019	2019	CD
cord-320331-wtxja5i9	347	20	(	(	-LRB-
cord-320331-wtxja5i9	348	1	COVID-19	covid-19	LS
cord-320331-wtxja5i9	348	2	)	)	-RRB-
cord-320331-wtxja5i9	348	3	-United	-unite	VBD
cord-320331-wtxja5i9	348	4	States	States	NNP
cord-320331-wtxja5i9	348	5	Cryo	Cryo	NNP
cord-320331-wtxja5i9	348	6	-	-	HYPH
cord-320331-wtxja5i9	348	7	EM	EM	NNP
cord-320331-wtxja5i9	348	8	structure	structure	NN
cord-320331-wtxja5i9	348	9	of	of	IN
cord-320331-wtxja5i9	348	10	the	the	DT
cord-320331-wtxja5i9	348	11	2019-nCoV	2019-ncov	CD
cord-320331-wtxja5i9	348	12	spike	spike	NN
cord-320331-wtxja5i9	348	13	in	in	IN
cord-320331-wtxja5i9	348	14	the	the	DT
cord-320331-wtxja5i9	348	15	prefusion	prefusion	NN
cord-320331-wtxja5i9	348	16	conformation	conformation	NN
cord-320331-wtxja5i9	348	17	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	348	18	II	II	NNP
cord-320331-wtxja5i9	348	19	,	,	,
cord-320331-wtxja5i9	348	20	from	from	IN
cord-320331-wtxja5i9	348	21	vasoconstrictor	vasoconstrictor	NN
cord-320331-wtxja5i9	348	22	to	to	IN
cord-320331-wtxja5i9	348	23	growth	growth	NN
cord-320331-wtxja5i9	348	24	factor	factor	NN
cord-320331-wtxja5i9	349	1	:	:	:
cord-320331-wtxja5i9	349	2	a	a	DT
cord-320331-wtxja5i9	349	3	paradigm	paradigm	NN
cord-320331-wtxja5i9	349	4	shift	shift	NN
cord-320331-wtxja5i9	349	5	Hemodynamic	Hemodynamic	NNP
cord-320331-wtxja5i9	349	6	responses	response	NNS
cord-320331-wtxja5i9	349	7	to	to	IN
cord-320331-wtxja5i9	349	8	acute	acute	JJ
cord-320331-wtxja5i9	349	9	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	349	10	II	ii	CD
cord-320331-wtxja5i9	349	11	infusion	infusion	NN
cord-320331-wtxja5i9	349	12	are	be	VBP
cord-320331-wtxja5i9	349	13	exacerbated	exacerbate	VBN
cord-320331-wtxja5i9	349	14	in	in	IN
cord-320331-wtxja5i9	349	15	male	male	NN
cord-320331-wtxja5i9	349	16	versus	versus	IN
cord-320331-wtxja5i9	349	17	female	female	JJ
cord-320331-wtxja5i9	349	18	spontaneously	spontaneously	RB
cord-320331-wtxja5i9	349	19	hypertensive	hypertensive	JJ
cord-320331-wtxja5i9	349	20	rats	rat	NNS
cord-320331-wtxja5i9	349	21	Role	role	NN
cord-320331-wtxja5i9	349	22	of	of	IN
cord-320331-wtxja5i9	349	23	the	the	DT
cord-320331-wtxja5i9	349	24	renin	renin	NN
cord-320331-wtxja5i9	349	25	-	-	HYPH
cord-320331-wtxja5i9	349	26	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	349	27	-	-	HYPH
cord-320331-wtxja5i9	349	28	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	349	29	system	system	NN
cord-320331-wtxja5i9	349	30	beyond	beyond	IN
cord-320331-wtxja5i9	349	31	blood	blood	NN
cord-320331-wtxja5i9	349	32	pressure	pressure	NN
cord-320331-wtxja5i9	349	33	regulation	regulation	NN
cord-320331-wtxja5i9	349	34	:	:	:
cord-320331-wtxja5i9	349	35	molecular	molecular	JJ
cord-320331-wtxja5i9	349	36	and	and	CC
cord-320331-wtxja5i9	349	37	cellular	cellular	JJ
cord-320331-wtxja5i9	349	38	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	349	39	involved	involve	VBN
cord-320331-wtxja5i9	349	40	in	in	IN
cord-320331-wtxja5i9	349	41	end	end	NN
cord-320331-wtxja5i9	349	42	-	-	HYPH
cord-320331-wtxja5i9	349	43	organ	organ	NN
cord-320331-wtxja5i9	349	44	damage	damage	NN
cord-320331-wtxja5i9	349	45	during	during	IN
cord-320331-wtxja5i9	349	46	arterial	arterial	JJ
cord-320331-wtxja5i9	349	47	hypertension	hypertension	NN
cord-320331-wtxja5i9	349	48	Role	role	NN
cord-320331-wtxja5i9	349	49	of	of	IN
cord-320331-wtxja5i9	349	50	the	the	DT
cord-320331-wtxja5i9	349	51	ACE2	ACE2	NNP
cord-320331-wtxja5i9	349	52	/	/	SYM
cord-320331-wtxja5i9	349	53	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	349	54	1	1	CD
cord-320331-wtxja5i9	349	55	-	-	SYM
cord-320331-wtxja5i9	349	56	7	7	CD
cord-320331-wtxja5i9	349	57	axis	axis	NN
cord-320331-wtxja5i9	349	58	of	of	IN
cord-320331-wtxja5i9	349	59	the	the	DT
cord-320331-wtxja5i9	349	60	reninangiotensin	reninangiotensin	JJ
cord-320331-wtxja5i9	349	61	system	system	NN
cord-320331-wtxja5i9	349	62	in	in	IN
cord-320331-wtxja5i9	349	63	heart	heart	NN
cord-320331-wtxja5i9	349	64	failure	failure	NN
cord-320331-wtxja5i9	349	65	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	349	66	disease	disease	NN
cord-320331-wtxja5i9	349	67	2019	2019	CD
cord-320331-wtxja5i9	349	68	(	(	-LRB-
cord-320331-wtxja5i9	349	69	covid-19	covid-19	NNP
cord-320331-wtxja5i9	349	70	)	)	-RRB-
cord-320331-wtxja5i9	349	71	and	and	CC
cord-320331-wtxja5i9	349	72	cardiovascular	cardiovascular	JJ
cord-320331-wtxja5i9	349	73	disease	disease	NN
cord-320331-wtxja5i9	349	74	:	:	:
cord-320331-wtxja5i9	349	75	a	a	DT
cord-320331-wtxja5i9	349	76	viewpoint	viewpoint	NN
cord-320331-wtxja5i9	349	77	on	on	IN
cord-320331-wtxja5i9	349	78	the	the	DT
cord-320331-wtxja5i9	349	79	potential	potential	JJ
cord-320331-wtxja5i9	349	80	influence	influence	NN
cord-320331-wtxja5i9	349	81	of	of	IN
cord-320331-wtxja5i9	349	82	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	349	83	-	-	HYPH
cord-320331-wtxja5i9	349	84	converting	convert	VBG
cord-320331-wtxja5i9	349	85	enzyme	enzyme	NN
cord-320331-wtxja5i9	349	86	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	349	87	/	/	SYM
cord-320331-wtxja5i9	349	88	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	349	89	receptor	receptor	NN
cord-320331-wtxja5i9	349	90	blockers	blocker	NNS
cord-320331-wtxja5i9	349	91	on	on	IN
cord-320331-wtxja5i9	349	92	onset	onset	NN
cord-320331-wtxja5i9	349	93	and	and	CC
cord-320331-wtxja5i9	349	94	severity	severity	NN
cord-320331-wtxja5i9	349	95	of	of	IN
cord-320331-wtxja5i9	349	96	severe	severe	JJ
cord-320331-wtxja5i9	349	97	acute	acute	JJ
cord-320331-wtxja5i9	349	98	respiratory	respiratory	JJ
cord-320331-wtxja5i9	349	99	syndrome	syndrome	NN
cord-320331-wtxja5i9	349	100	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	350	1	2	2	CD
cord-320331-wtxja5i9	350	2	infection	infection	NN
cord-320331-wtxja5i9	350	3	Inhibition	inhibition	NN
cord-320331-wtxja5i9	350	4	of	of	IN
cord-320331-wtxja5i9	350	5	SARS	SARS	NNP
cord-320331-wtxja5i9	350	6	-	-	HYPH
cord-320331-wtxja5i9	350	7	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	350	8	infections	infection	NNS
cord-320331-wtxja5i9	350	9	in	in	IN
cord-320331-wtxja5i9	350	10	engineered	engineer	VBN
cord-320331-wtxja5i9	350	11	human	human	JJ
cord-320331-wtxja5i9	350	12	tissues	tissue	NNS
cord-320331-wtxja5i9	350	13	using	use	VBG
cord-320331-wtxja5i9	350	14	clinicalgrade	clinicalgrade	NNP
cord-320331-wtxja5i9	350	15	soluble	soluble	JJ
cord-320331-wtxja5i9	350	16	human	human	JJ
cord-320331-wtxja5i9	350	17	ACE2	ACE2	NNP
cord-320331-wtxja5i9	350	18	the	the	DT
cord-320331-wtxja5i9	350	19	functional	functional	JJ
cord-320331-wtxja5i9	350	20	receptor	receptor	NN
cord-320331-wtxja5i9	350	21	for	for	IN
cord-320331-wtxja5i9	350	22	SARS	SARS	NNP
cord-320331-wtxja5i9	350	23	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	350	24	.	.	.
cord-320331-wtxja5i9	351	1	A	a	DT
cord-320331-wtxja5i9	351	2	first	first	JJ
cord-320331-wtxja5i9	351	3	step	step	NN
cord-320331-wtxja5i9	351	4	in	in	IN
cord-320331-wtxja5i9	351	5	understanding	understand	VBG
cord-320331-wtxja5i9	351	6	SARS	SARS	NNP
cord-320331-wtxja5i9	351	7	pathogenesis	pathogenesis	NN
cord-320331-wtxja5i9	351	8	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	351	9	-	-	HYPH
cord-320331-wtxja5i9	351	10	converting	convert	VBG
cord-320331-wtxja5i9	351	11	enzyme	enzyme	NN
cord-320331-wtxja5i9	351	12	2	2	CD
cord-320331-wtxja5i9	351	13	:	:	:
cord-320331-wtxja5i9	351	14	the	the	DT
cord-320331-wtxja5i9	351	15	first	first	JJ
cord-320331-wtxja5i9	351	16	decade	decade	NN
cord-320331-wtxja5i9	351	17	.	.	.
cord-320331-wtxja5i9	352	1	International	international	JJ
cord-320331-wtxja5i9	352	2	journal	journal	NN
cord-320331-wtxja5i9	352	3	of	of	IN
cord-320331-wtxja5i9	352	4	hypertension	hypertension	NNP
cord-320331-wtxja5i9	353	1	The	the	DT
cord-320331-wtxja5i9	353	2	protein	protein	NN
cord-320331-wtxja5i9	353	3	expression	expression	NN
cord-320331-wtxja5i9	353	4	profile	profile	NN
cord-320331-wtxja5i9	353	5	of	of	IN
cord-320331-wtxja5i9	353	6	ACE2	ACE2	NNP
cord-320331-wtxja5i9	353	7	in	in	IN
cord-320331-wtxja5i9	353	8	human	human	JJ
cord-320331-wtxja5i9	353	9	tissues	tissue	NNS
cord-320331-wtxja5i9	353	10	High	high	JJ
cord-320331-wtxja5i9	353	11	expression	expression	NN
cord-320331-wtxja5i9	353	12	of	of	IN
cord-320331-wtxja5i9	353	13	ACE2	ACE2	NNP
cord-320331-wtxja5i9	353	14	receptor	receptor	NN
cord-320331-wtxja5i9	353	15	of	of	IN
cord-320331-wtxja5i9	353	16	Severe	severe	JJ
cord-320331-wtxja5i9	353	17	respiratory	respiratory	JJ
cord-320331-wtxja5i9	353	18	SARS	SARS	NNP
cord-320331-wtxja5i9	353	19	-	-	HYPH
cord-320331-wtxja5i9	353	20	CoV2	cov2	NN
cord-320331-wtxja5i9	353	21	infection	infection	NN
cord-320331-wtxja5i9	353	22	:	:	:
cord-320331-wtxja5i9	354	1	Does	do	VBZ
cord-320331-wtxja5i9	354	2	ACE2	ACE2	NNP
cord-320331-wtxja5i9	354	3	receptor	receptor	NN
cord-320331-wtxja5i9	354	4	matter	matter	NN
cord-320331-wtxja5i9	354	5	Impact	impact	NN
cord-320331-wtxja5i9	354	6	of	of	IN
cord-320331-wtxja5i9	354	7	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	354	8	on	on	IN
cord-320331-wtxja5i9	354	9	Alzheimer	Alzheimer	NNP
cord-320331-wtxja5i9	354	10	's	's	POS
cord-320331-wtxja5i9	354	11	Disease	Disease	NNP
cord-320331-wtxja5i9	354	12	Risk	Risk	NNP
cord-320331-wtxja5i9	354	13	:	:	:
cord-320331-wtxja5i9	355	1	Viewpoint	viewpoint	NN
cord-320331-wtxja5i9	355	2	for	for	IN
cord-320331-wtxja5i9	355	3	Research	Research	NNP
cord-320331-wtxja5i9	355	4	Action	Action	NNP
cord-320331-wtxja5i9	356	1	The	the	DT
cord-320331-wtxja5i9	356	2	neuroinvasive	neuroinvasive	JJ
cord-320331-wtxja5i9	356	3	potential	potential	NN
cord-320331-wtxja5i9	356	4	of	of	IN
cord-320331-wtxja5i9	356	5	SARS	SARS	NNP
cord-320331-wtxja5i9	356	6	-	-	HYPH
cord-320331-wtxja5i9	356	7	CoV2	CoV2	NNP
cord-320331-wtxja5i9	356	8	may	may	MD
cord-320331-wtxja5i9	356	9	play	play	VB
cord-320331-wtxja5i9	356	10	a	a	DT
cord-320331-wtxja5i9	356	11	role	role	NN
cord-320331-wtxja5i9	356	12	in	in	IN
cord-320331-wtxja5i9	356	13	the	the	DT
cord-320331-wtxja5i9	356	14	respiratory	respiratory	JJ
cord-320331-wtxja5i9	356	15	failure	failure	NN
cord-320331-wtxja5i9	356	16	of	of	IN
cord-320331-wtxja5i9	356	17	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	356	18	patients	patient	NNS
cord-320331-wtxja5i9	356	19	Self	Self	NNP
cord-320331-wtxja5i9	356	20	-	-	HYPH
cord-320331-wtxja5i9	356	21	reported	report	VBN
cord-320331-wtxja5i9	356	22	olfactory	olfactory	NN
cord-320331-wtxja5i9	356	23	and	and	CC
cord-320331-wtxja5i9	356	24	taste	taste	VBP
cord-320331-wtxja5i9	356	25	disorders	disorder	NNS
cord-320331-wtxja5i9	356	26	in	in	IN
cord-320331-wtxja5i9	356	27	patients	patient	NNS
cord-320331-wtxja5i9	356	28	with	with	IN
cord-320331-wtxja5i9	356	29	severe	severe	JJ
cord-320331-wtxja5i9	356	30	acute	acute	JJ
cord-320331-wtxja5i9	356	31	respiratory	respiratory	JJ
cord-320331-wtxja5i9	356	32	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	356	33	2	2	CD
cord-320331-wtxja5i9	356	34	infection	infection	NN
cord-320331-wtxja5i9	356	35	:	:	:
cord-320331-wtxja5i9	356	36	a	a	DT
cord-320331-wtxja5i9	356	37	cross	cross	JJ
cord-320331-wtxja5i9	356	38	-	-	JJ
cord-320331-wtxja5i9	356	39	sectional	sectional	JJ
cord-320331-wtxja5i9	356	40	study	study	NN
cord-320331-wtxja5i9	356	41	Current	current	JJ
cord-320331-wtxja5i9	356	42	evidence	evidence	NN
cord-320331-wtxja5i9	356	43	on	on	IN
cord-320331-wtxja5i9	356	44	pancreatic	pancreatic	JJ
cord-320331-wtxja5i9	356	45	involvement	involvement	NN
cord-320331-wtxja5i9	356	46	in	in	IN
cord-320331-wtxja5i9	356	47	SARS	SARS	NNP
cord-320331-wtxja5i9	356	48	-	-	HYPH
cord-320331-wtxja5i9	356	49	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	356	50	infection	infection	NN
cord-320331-wtxja5i9	356	51	COVID-19	covid-19	VBP
cord-320331-wtxja5i9	356	52	in	in	IN
cord-320331-wtxja5i9	356	53	people	people	NNS
cord-320331-wtxja5i9	356	54	with	with	IN
cord-320331-wtxja5i9	356	55	diabetes	diabetes	NN
cord-320331-wtxja5i9	356	56	:	:	:
cord-320331-wtxja5i9	356	57	understanding	understand	VBG
cord-320331-wtxja5i9	356	58	the	the	DT
cord-320331-wtxja5i9	356	59	reasons	reason	NNS
cord-320331-wtxja5i9	356	60	for	for	IN
cord-320331-wtxja5i9	356	61	worse	bad	JJR
cord-320331-wtxja5i9	356	62	outcomes	outcome	NNS
cord-320331-wtxja5i9	356	63	.	.	.
cord-320331-wtxja5i9	357	1	The	the	DT
cord-320331-wtxja5i9	357	2	lancet	lancet	NNP
cord-320331-wtxja5i9	357	3	Diabetes	Diabetes	NNP
cord-320331-wtxja5i9	357	4	&	&	CC
cord-320331-wtxja5i9	357	5	endocrinology	endocrinology	NNP
cord-320331-wtxja5i9	357	6	ACE	ACE	NNP
cord-320331-wtxja5i9	357	7	and	and	CC
cord-320331-wtxja5i9	357	8	ACE2	ACE2	NNP
cord-320331-wtxja5i9	357	9	in	in	IN
cord-320331-wtxja5i9	357	10	kidney	kidney	NN
cord-320331-wtxja5i9	357	11	disease	disease	NN
cord-320331-wtxja5i9	357	12	Rodent	Rodent	NNP
cord-320331-wtxja5i9	357	13	models	model	NNS
cord-320331-wtxja5i9	357	14	of	of	IN
cord-320331-wtxja5i9	357	15	streptozotocin	streptozotocin	NNS
cord-320331-wtxja5i9	357	16	-	-	HYPH
cord-320331-wtxja5i9	357	17	induced	induce	VBN
cord-320331-wtxja5i9	357	18	diabetic	diabetic	JJ
cord-320331-wtxja5i9	357	19	nephropathy	nephropathy	NN
cord-320331-wtxja5i9	357	20	(	(	-LRB-
cord-320331-wtxja5i9	357	21	Methods	Methods	NNPS
cord-320331-wtxja5i9	357	22	in	in	IN
cord-320331-wtxja5i9	357	23	Renal	Renal	NNP
cord-320331-wtxja5i9	357	24	Research	Research	NNP
cord-320331-wtxja5i9	357	25	)	)	-RRB-
cord-320331-wtxja5i9	357	26	Relationship	relationship	NN
cord-320331-wtxja5i9	357	27	between	between	IN
cord-320331-wtxja5i9	357	28	renal	renal	JJ
cord-320331-wtxja5i9	357	29	injury	injury	NN
cord-320331-wtxja5i9	357	30	and	and	CC
cord-320331-wtxja5i9	357	31	the	the	DT
cord-320331-wtxja5i9	357	32	antagonistic	antagonistic	JJ
cord-320331-wtxja5i9	357	33	roles	role	NNS
cord-320331-wtxja5i9	357	34	of	of	IN
cord-320331-wtxja5i9	357	35	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	357	36	-	-	HYPH
cord-320331-wtxja5i9	357	37	converting	convert	VBG
cord-320331-wtxja5i9	357	38	enzyme	enzyme	NN
cord-320331-wtxja5i9	357	39	(	(	-LRB-
cord-320331-wtxja5i9	357	40	ACE	ACE	NNP
cord-320331-wtxja5i9	357	41	)	)	-RRB-
cord-320331-wtxja5i9	357	42	and	and	CC
cord-320331-wtxja5i9	358	1	ACE2	ACE2	NNP
cord-320331-wtxja5i9	358	2	Genetic	genetic	JJ
cord-320331-wtxja5i9	358	3	deletion	deletion	NN
cord-320331-wtxja5i9	358	4	of	of	IN
cord-320331-wtxja5i9	358	5	ACE2	ACE2	NNP
cord-320331-wtxja5i9	358	6	induces	induce	VBZ
cord-320331-wtxja5i9	358	7	vascular	vascular	JJ
cord-320331-wtxja5i9	358	8	dysfunction	dysfunction	NN
cord-320331-wtxja5i9	358	9	in	in	IN
cord-320331-wtxja5i9	358	10	C57BL/6	C57BL/6	NNP
cord-320331-wtxja5i9	358	11	mice	mouse	NNS
cord-320331-wtxja5i9	358	12	:	:	:
cord-320331-wtxja5i9	358	13	role	role	NN
cord-320331-wtxja5i9	358	14	of	of	IN
cord-320331-wtxja5i9	358	15	nitric	nitric	NN
cord-320331-wtxja5i9	358	16	oxide	oxide	NN
cord-320331-wtxja5i9	358	17	imbalance	imbalance	NN
cord-320331-wtxja5i9	358	18	and	and	CC
cord-320331-wtxja5i9	358	19	oxidative	oxidative	JJ
cord-320331-wtxja5i9	358	20	stress	stress	NN
cord-320331-wtxja5i9	359	1	Vascular	vascular	JJ
cord-320331-wtxja5i9	359	2	oxidative	oxidative	JJ
cord-320331-wtxja5i9	359	3	stress	stress	NN
cord-320331-wtxja5i9	359	4	:	:	:
cord-320331-wtxja5i9	360	1	Impact	impact	NN
cord-320331-wtxja5i9	360	2	and	and	CC
cord-320331-wtxja5i9	360	3	therapeutic	therapeutic	JJ
cord-320331-wtxja5i9	360	4	approaches	approach	NNS
cord-320331-wtxja5i9	361	1	Pharmacological	pharmacological	JJ
cord-320331-wtxja5i9	361	2	characteristics	characteristic	NNS
cord-320331-wtxja5i9	361	3	of	of	IN
cord-320331-wtxja5i9	361	4	patients	patient	NNS
cord-320331-wtxja5i9	361	5	infected	infect	VBN
cord-320331-wtxja5i9	361	6	with	with	IN
cord-320331-wtxja5i9	361	7	SARS	SARS	NNP
cord-320331-wtxja5i9	361	8	-	-	HYPH
cord-320331-wtxja5i9	361	9	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	361	10	admitted	admit	VBD
cord-320331-wtxja5i9	361	11	to	to	IN
cord-320331-wtxja5i9	361	12	Intensive	Intensive	NNP
cord-320331-wtxja5i9	361	13	Care	Care	NNP
cord-320331-wtxja5i9	361	14	Unit	Unit	NNP
cord-320331-wtxja5i9	361	15	in	in	IN
cord-320331-wtxja5i9	361	16	South	South	NNP
cord-320331-wtxja5i9	361	17	of	of	IN
cord-320331-wtxja5i9	361	18	France	France	NNP
cord-320331-wtxja5i9	361	19	Application	Application	NNP
cord-320331-wtxja5i9	361	20	of	of	IN
cord-320331-wtxja5i9	361	21	System	System	NNP
cord-320331-wtxja5i9	361	22	Biology	Biology	NNP
cord-320331-wtxja5i9	361	23	to	to	TO
cord-320331-wtxja5i9	361	24	Explore	explore	VB
cord-320331-wtxja5i9	361	25	the	the	DT
cord-320331-wtxja5i9	361	26	Association	Association	NNP
cord-320331-wtxja5i9	361	27	of	of	IN
cord-320331-wtxja5i9	361	28	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	361	29	-	-	HYPH
cord-320331-wtxja5i9	361	30	Converting	convert	VBG
cord-320331-wtxja5i9	361	31	Enzyme	Enzyme	NNP
cord-320331-wtxja5i9	361	32	2	2	CD
cord-320331-wtxja5i9	361	33	(	(	-LRB-
cord-320331-wtxja5i9	361	34	ACE2	ACE2	NNP
cord-320331-wtxja5i9	361	35	)	)	-RRB-
cord-320331-wtxja5i9	361	36	,	,	,
cord-320331-wtxja5i9	361	37	and	and	CC
cord-320331-wtxja5i9	361	38	Carbonic	Carbonic	NNP
cord-320331-wtxja5i9	361	39	Anhydrase	Anhydrase	NNP
cord-320331-wtxja5i9	361	40	(	(	-LRB-
cord-320331-wtxja5i9	361	41	CA	CA	NNP
cord-320331-wtxja5i9	361	42	)	)	-RRB-
cord-320331-wtxja5i9	361	43	in	in	IN
cord-320331-wtxja5i9	361	44	Pathogenesis	Pathogenesis	NNP
cord-320331-wtxja5i9	361	45	of	of	IN
cord-320331-wtxja5i9	361	46	SARS	SARS	NNP
cord-320331-wtxja5i9	361	47	-	-	HYPH
cord-320331-wtxja5i9	361	48	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	362	1	In	in	IN
cord-320331-wtxja5i9	362	2	vitro	vitro	FW
cord-320331-wtxja5i9	362	3	analysis	analysis	NN
cord-320331-wtxja5i9	362	4	of	of	IN
cord-320331-wtxja5i9	362	5	the	the	DT
cord-320331-wtxja5i9	362	6	renin	renin	NN
cord-320331-wtxja5i9	362	7	-	-	HYPH
cord-320331-wtxja5i9	362	8	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	362	9	system	system	NN
cord-320331-wtxja5i9	362	10	and	and	CC
cord-320331-wtxja5i9	362	11	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	362	12	gene	gene	NN
cord-320331-wtxja5i9	362	13	transcripts	transcript	NNS
cord-320331-wtxja5i9	362	14	in	in	IN
cord-320331-wtxja5i9	362	15	human	human	JJ
cord-320331-wtxja5i9	362	16	bronchial	bronchial	JJ
cord-320331-wtxja5i9	362	17	epithelial	epithelial	JJ
cord-320331-wtxja5i9	362	18	cells	cell	NNS
cord-320331-wtxja5i9	362	19	after	after	IN
cord-320331-wtxja5i9	362	20	infection	infection	NN
cord-320331-wtxja5i9	362	21	with	with	IN
cord-320331-wtxja5i9	362	22	severe	severe	JJ
cord-320331-wtxja5i9	362	23	acute	acute	JJ
cord-320331-wtxja5i9	362	24	respiratory	respiratory	JJ
cord-320331-wtxja5i9	362	25	syndrome	syndrome	NN
cord-320331-wtxja5i9	362	26	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	363	1	The	the	DT
cord-320331-wtxja5i9	363	2	Effects	effect	NNS
cord-320331-wtxja5i9	363	3	of	of	IN
cord-320331-wtxja5i9	363	4	ARBs	arb	NNS
cord-320331-wtxja5i9	363	5	,	,	,
cord-320331-wtxja5i9	363	6	ACEis	ACEis	NNP
cord-320331-wtxja5i9	363	7	,	,	,
cord-320331-wtxja5i9	363	8	and	and	CC
cord-320331-wtxja5i9	363	9	Statins	Statins	NNPS
cord-320331-wtxja5i9	363	10	on	on	IN
cord-320331-wtxja5i9	363	11	Clinical	Clinical	NNP
cord-320331-wtxja5i9	363	12	Outcomes	Outcomes	NNPS
cord-320331-wtxja5i9	363	13	of	of	IN
cord-320331-wtxja5i9	363	14	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	363	15	Infection	Infection	NNP
cord-320331-wtxja5i9	363	16	Among	among	IN
cord-320331-wtxja5i9	363	17	Nursing	Nursing	NNP
cord-320331-wtxja5i9	363	18	Home	home	NN
cord-320331-wtxja5i9	363	19	Residents	resident	NNS
cord-320331-wtxja5i9	364	1	The	the	DT
cord-320331-wtxja5i9	364	2	Risk	risk	NN
cord-320331-wtxja5i9	364	3	of	of	IN
cord-320331-wtxja5i9	364	4	Diabetes	diabetes	NN
cord-320331-wtxja5i9	364	5	on	on	IN
cord-320331-wtxja5i9	364	6	Clinical	Clinical	NNP
cord-320331-wtxja5i9	364	7	Outcomes	Outcomes	NNPS
cord-320331-wtxja5i9	364	8	in	in	IN
cord-320331-wtxja5i9	364	9	Patients	patient	NNS
cord-320331-wtxja5i9	364	10	with	with	IN
cord-320331-wtxja5i9	364	11	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	364	12	Disease	Disease	NNP
cord-320331-wtxja5i9	364	13	2019	2019	CD
cord-320331-wtxja5i9	364	14	:	:	:
cord-320331-wtxja5i9	365	1	A	a	DT
cord-320331-wtxja5i9	365	2	Retrospective	Retrospective	NNP
cord-320331-wtxja5i9	365	3	Cohort	Cohort	NNP
cord-320331-wtxja5i9	365	4	Study	Study	NNP
cord-320331-wtxja5i9	365	5	Interaction	Interaction	NNP
cord-320331-wtxja5i9	365	6	between	between	IN
cord-320331-wtxja5i9	365	7	RAAS	RAAS	NNP
cord-320331-wtxja5i9	365	8	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	365	9	and	and	CC
cord-320331-wtxja5i9	365	10	ACE2	ACE2	NNP
cord-320331-wtxja5i9	365	11	in	in	IN
cord-320331-wtxja5i9	365	12	the	the	DT
cord-320331-wtxja5i9	365	13	context	context	NN
cord-320331-wtxja5i9	365	14	of	of	IN
cord-320331-wtxja5i9	365	15	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	365	16	Kidney	kidney	NN
cord-320331-wtxja5i9	365	17	and	and	CC
cord-320331-wtxja5i9	365	18	lung	lung	NN
cord-320331-wtxja5i9	365	19	ACE2	ACE2	NNP
cord-320331-wtxja5i9	365	20	expression	expression	NN
cord-320331-wtxja5i9	365	21	after	after	IN
cord-320331-wtxja5i9	365	22	an	an	DT
cord-320331-wtxja5i9	365	23	ACE	ace	NN
cord-320331-wtxja5i9	365	24	inhibitor	inhibitor	NN
cord-320331-wtxja5i9	365	25	or	or	CC
cord-320331-wtxja5i9	365	26	an	an	DT
cord-320331-wtxja5i9	365	27	Ang	Ang	NNP
cord-320331-wtxja5i9	365	28	II	II	NNP
cord-320331-wtxja5i9	365	29	receptor	receptor	NN
cord-320331-wtxja5i9	365	30	blocker	blocker	NN
cord-320331-wtxja5i9	365	31	:	:	:
cord-320331-wtxja5i9	365	32	Implications	implication	NNS
cord-320331-wtxja5i9	365	33	for	for	IN
cord-320331-wtxja5i9	365	34	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	365	35	Angiotensin	Angiotensin	NNP
cord-320331-wtxja5i9	365	36	III	III	NNP
cord-320331-wtxja5i9	365	37	stimulates	stimulate	VBZ
cord-320331-wtxja5i9	365	38	aldosterone	aldosterone	NN
cord-320331-wtxja5i9	365	39	secretion	secretion	NN
cord-320331-wtxja5i9	365	40	from	from	IN
cord-320331-wtxja5i9	365	41	adrenal	adrenal	JJ
cord-320331-wtxja5i9	365	42	gland	gland	NN
cord-320331-wtxja5i9	365	43	partially	partially	RB
cord-320331-wtxja5i9	365	44	via	via	IN
cord-320331-wtxja5i9	365	45	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	365	46	II	II	NNP
cord-320331-wtxja5i9	365	47	type	type	NN
cord-320331-wtxja5i9	365	48	2	2	CD
cord-320331-wtxja5i9	365	49	receptor	receptor	NN
cord-320331-wtxja5i9	365	50	but	but	CC
cord-320331-wtxja5i9	365	51	not	not	RB
cord-320331-wtxja5i9	365	52	angiotensin	angiotensin	NN
cord-320331-wtxja5i9	365	53	II	II	NNP
cord-320331-wtxja5i9	366	1	type	type	NN
cord-320331-wtxja5i9	366	2	1	1	CD
cord-320331-wtxja5i9	366	3	receptor	receptor	NN
cord-320331-wtxja5i9	366	4	Assessment	Assessment	NNP
cord-320331-wtxja5i9	366	5	of	of	IN
cord-320331-wtxja5i9	366	6	Hypokalemia	Hypokalemia	NNP
cord-320331-wtxja5i9	366	7	and	and	CC
cord-320331-wtxja5i9	366	8	Clinical	Clinical	NNP
cord-320331-wtxja5i9	366	9	Characteristics	Characteristics	NNPS
cord-320331-wtxja5i9	366	10	in	in	IN
cord-320331-wtxja5i9	366	11	Patients	patient	NNS
cord-320331-wtxja5i9	366	12	With	with	IN
cord-320331-wtxja5i9	366	13	Coronavirus	Coronavirus	NNP
cord-320331-wtxja5i9	366	14	Disease	Disease	NNP
cord-320331-wtxja5i9	366	15	Non	non	JJ
cord-320331-wtxja5i9	366	16	-	-	JJ
cord-320331-wtxja5i9	366	17	steroidal	steroidal	JJ
cord-320331-wtxja5i9	366	18	antiinflammatory	antiinflammatory	JJ
cord-320331-wtxja5i9	366	19	drugs	drug	NNS
cord-320331-wtxja5i9	366	20	in	in	IN
cord-320331-wtxja5i9	366	21	management	management	NN
cord-320331-wtxja5i9	366	22	of	of	IN
cord-320331-wtxja5i9	366	23	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	366	24	;	;	:
cord-320331-wtxja5i9	366	25	a	a	DT
cord-320331-wtxja5i9	366	26	systematic	systematic	JJ
cord-320331-wtxja5i9	366	27	review	review	NN
cord-320331-wtxja5i9	366	28	on	on	IN
cord-320331-wtxja5i9	366	29	current	current	JJ
cord-320331-wtxja5i9	366	30	evidence	evidence	NN
cord-320331-wtxja5i9	366	31	Associations	association	NNS
cord-320331-wtxja5i9	366	32	between	between	IN
cord-320331-wtxja5i9	366	33	mmune	mmune	JJ
cord-320331-wtxja5i9	366	34	-	-	HYPH
cord-320331-wtxja5i9	366	35	suppressive	suppressive	JJ
cord-320331-wtxja5i9	366	36	and	and	CC
cord-320331-wtxja5i9	366	37	stimulating	stimulate	VBG
cord-320331-wtxja5i9	366	38	drugs	drug	NNS
cord-320331-wtxja5i9	366	39	and	and	CC
cord-320331-wtxja5i9	366	40	novel	novel	NN
cord-320331-wtxja5i9	366	41	COVID-19	covid-19	CD
cord-320331-wtxja5i9	366	42	--a	--a	NNP
cord-320331-wtxja5i9	366	43	systematic	systematic	JJ
cord-320331-wtxja5i9	366	44	review	review	NN
cord-320331-wtxja5i9	366	45	of	of	IN
cord-320331-wtxja5i9	366	46	current	current	JJ
cord-320331-wtxja5i9	366	47	evidence	evidence	NN
cord-320331-wtxja5i9	367	1	Indomethacin	Indomethacin	NNP
cord-320331-wtxja5i9	367	2	has	have	VBZ
cord-320331-wtxja5i9	367	3	a	a	DT
cord-320331-wtxja5i9	367	4	potent	potent	JJ
cord-320331-wtxja5i9	367	5	antiviral	antiviral	JJ
cord-320331-wtxja5i9	367	6	activity	activity	NN
cord-320331-wtxja5i9	367	7	against	against	IN
cord-320331-wtxja5i9	367	8	SARS	SARS	NNP
cord-320331-wtxja5i9	367	9	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	368	1	The	the	DT
cord-320331-wtxja5i9	368	2	effect	effect	NN
cord-320331-wtxja5i9	368	3	of	of	IN
cord-320331-wtxja5i9	368	4	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	368	5	treatment	treatment	NN
cord-320331-wtxja5i9	368	6	on	on	IN
cord-320331-wtxja5i9	368	7	patients	patient	NNS
cord-320331-wtxja5i9	368	8	with	with	IN
cord-320331-wtxja5i9	368	9	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	368	10	infection	infection	NN
cord-320331-wtxja5i9	368	11	:	:	:
cord-320331-wtxja5i9	368	12	a	a	DT
cord-320331-wtxja5i9	368	13	systematic	systematic	JJ
cord-320331-wtxja5i9	368	14	review	review	NN
cord-320331-wtxja5i9	368	15	and	and	CC
cord-320331-wtxja5i9	368	16	meta	meta	NNP
cord-320331-wtxja5i9	368	17	-	-	HYPH
cord-320331-wtxja5i9	368	18	analysis	analysis	NN
cord-320331-wtxja5i9	368	19	Impact	Impact	NNP
cord-320331-wtxja5i9	368	20	of	of	IN
cord-320331-wtxja5i9	368	21	corticosteroid	corticosteroid	NN
cord-320331-wtxja5i9	368	22	therapy	therapy	NN
cord-320331-wtxja5i9	368	23	on	on	IN
cord-320331-wtxja5i9	368	24	outcomes	outcome	NNS
cord-320331-wtxja5i9	368	25	of	of	IN
cord-320331-wtxja5i9	368	26	persons	person	NNS
cord-320331-wtxja5i9	368	27	with	with	IN
cord-320331-wtxja5i9	368	28	SARS	SARS	NNP
cord-320331-wtxja5i9	368	29	-	-	HYPH
cord-320331-wtxja5i9	368	30	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	368	31	,	,	,
cord-320331-wtxja5i9	368	32	SARS	SARS	NNP
cord-320331-wtxja5i9	368	33	-	-	HYPH
cord-320331-wtxja5i9	368	34	CoV	CoV	NNP
cord-320331-wtxja5i9	368	35	,	,	,
cord-320331-wtxja5i9	368	36	or	or	CC
cord-320331-wtxja5i9	368	37	MERS	MERS	NNP
cord-320331-wtxja5i9	368	38	-	-	HYPH
cord-320331-wtxja5i9	368	39	CoV	CoV	NNP
cord-320331-wtxja5i9	368	40	infection	infection	NN
cord-320331-wtxja5i9	368	41	:	:	:
cord-320331-wtxja5i9	368	42	a	a	DT
cord-320331-wtxja5i9	368	43	systematic	systematic	JJ
cord-320331-wtxja5i9	368	44	review	review	NN
cord-320331-wtxja5i9	368	45	and	and	CC
cord-320331-wtxja5i9	368	46	meta	meta	NNP
cord-320331-wtxja5i9	368	47	-	-	HYPH
cord-320331-wtxja5i9	368	48	analysis	analysis	NN
cord-320331-wtxja5i9	368	49	Efficacy	Efficacy	NNP
cord-320331-wtxja5i9	368	50	and	and	CC
cord-320331-wtxja5i9	368	51	safety	safety	NN
cord-320331-wtxja5i9	368	52	of	of	IN
cord-320331-wtxja5i9	368	53	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	368	54	in	in	IN
cord-320331-wtxja5i9	368	55	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	368	56	based	base	VBN
cord-320331-wtxja5i9	368	57	on	on	IN
cord-320331-wtxja5i9	368	58	evidence	evidence	NN
cord-320331-wtxja5i9	368	59	for	for	IN
cord-320331-wtxja5i9	368	60	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	368	61	,	,	,
cord-320331-wtxja5i9	368	62	other	other	JJ
cord-320331-wtxja5i9	368	63	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	368	64	infections	infection	NNS
cord-320331-wtxja5i9	368	65	,	,	,
cord-320331-wtxja5i9	368	66	influenza	influenza	NN
cord-320331-wtxja5i9	368	67	,	,	,
cord-320331-wtxja5i9	368	68	community	community	NN
cord-320331-wtxja5i9	368	69	-	-	HYPH
cord-320331-wtxja5i9	368	70	acquired	acquire	VBN
cord-320331-wtxja5i9	368	71	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	368	72	and	and	CC
cord-320331-wtxja5i9	368	73	acute	acute	JJ
cord-320331-wtxja5i9	368	74	respiratory	respiratory	JJ
cord-320331-wtxja5i9	368	75	distress	distress	NN
cord-320331-wtxja5i9	368	76	syndrome	syndrome	NN
cord-320331-wtxja5i9	368	77	:	:	:
cord-320331-wtxja5i9	368	78	a	a	DT
cord-320331-wtxja5i9	368	79	systematic	systematic	JJ
cord-320331-wtxja5i9	368	80	review	review	NN
cord-320331-wtxja5i9	368	81	and	and	CC
cord-320331-wtxja5i9	368	82	meta	meta	NNP
cord-320331-wtxja5i9	368	83	-	-	HYPH
cord-320331-wtxja5i9	368	84	analysis	analysis	NN
cord-320331-wtxja5i9	368	85	NSAIDs	nsaid	NNS
cord-320331-wtxja5i9	368	86	may	may	MD
cord-320331-wtxja5i9	368	87	increase	increase	VB
cord-320331-wtxja5i9	368	88	the	the	DT
cord-320331-wtxja5i9	368	89	risk	risk	NN
cord-320331-wtxja5i9	368	90	of	of	IN
cord-320331-wtxja5i9	368	91	thrombosis	thrombosis	NN
cord-320331-wtxja5i9	368	92	and	and	CC
cord-320331-wtxja5i9	368	93	acute	acute	JJ
cord-320331-wtxja5i9	368	94	renal	renal	JJ
cord-320331-wtxja5i9	368	95	failure	failure	NN
cord-320331-wtxja5i9	368	96	in	in	IN
cord-320331-wtxja5i9	368	97	patients	patient	NNS
cord-320331-wtxja5i9	368	98	with	with	IN
cord-320331-wtxja5i9	368	99	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	368	100	infection	infection	NN
cord-320331-wtxja5i9	368	101	Thrombosis	Thrombosis	NNP
cord-320331-wtxja5i9	368	102	risk	risk	NN
cord-320331-wtxja5i9	368	103	associated	associate	VBN
cord-320331-wtxja5i9	368	104	with	with	IN
cord-320331-wtxja5i9	368	105	COVID-19	covid-19	JJ
cord-320331-wtxja5i9	368	106	infection	infection	NN
cord-320331-wtxja5i9	368	107	.	.	.
cord-320331-wtxja5i9	369	1	A	a	DT
cord-320331-wtxja5i9	369	2	scoping	scoping	NN
cord-320331-wtxja5i9	369	3	review	review	NN
cord-320331-wtxja5i9	369	4	Acute	acute	JJ
cord-320331-wtxja5i9	369	5	complications	complication	NNS
cord-320331-wtxja5i9	369	6	and	and	CC
cord-320331-wtxja5i9	369	7	mortality	mortality	NN
cord-320331-wtxja5i9	369	8	in	in	IN
cord-320331-wtxja5i9	369	9	hospitalized	hospitalize	VBN
cord-320331-wtxja5i9	369	10	patients	patient	NNS
cord-320331-wtxja5i9	369	11	with	with	IN
cord-320331-wtxja5i9	369	12	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	369	13	disease	disease	NN
cord-320331-wtxja5i9	369	14	2019	2019	CD
cord-320331-wtxja5i9	369	15	:	:	:
cord-320331-wtxja5i9	369	16	a	a	DT
cord-320331-wtxja5i9	369	17	systematic	systematic	JJ
cord-320331-wtxja5i9	369	18	review	review	NN
cord-320331-wtxja5i9	369	19	and	and	CC
cord-320331-wtxja5i9	369	20	meta	meta	NNP
cord-320331-wtxja5i9	369	21	-	-	HYPH
cord-320331-wtxja5i9	369	22	analysis	analysis	NN
cord-320331-wtxja5i9	370	1	The	the	DT
cord-320331-wtxja5i9	370	2	vascular	vascular	JJ
cord-320331-wtxja5i9	370	3	effects	effect	NNS
cord-320331-wtxja5i9	370	4	of	of	IN
cord-320331-wtxja5i9	370	5	COX-2	cox-2	JJ
cord-320331-wtxja5i9	370	6	selective	selective	JJ
cord-320331-wtxja5i9	370	7	inhibitors	inhibitor	NNS
cord-320331-wtxja5i9	370	8	Ibuprofen	Ibuprofen	NNP
cord-320331-wtxja5i9	370	9	and	and	CC
cord-320331-wtxja5i9	370	10	thromboembolism	thromboembolism	NN
cord-320331-wtxja5i9	370	11	in	in	IN
cord-320331-wtxja5i9	370	12	SARS	SARS	NNP
cord-320331-wtxja5i9	370	13	-	-	HYPH
cord-320331-wtxja5i9	370	14	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	370	15	Use	Use	NNP
cord-320331-wtxja5i9	370	16	of	of	IN
cord-320331-wtxja5i9	370	17	corticosteroids	corticosteroid	NNS
cord-320331-wtxja5i9	370	18	in	in	IN
cord-320331-wtxja5i9	370	19	coronavirus	coronavirus	NN
cord-320331-wtxja5i9	370	20	disease	disease	NN
cord-320331-wtxja5i9	370	21	2019	2019	CD
cord-320331-wtxja5i9	370	22	pneumonia	pneumonia	NN
cord-320331-wtxja5i9	370	23	:	:	:
cord-320331-wtxja5i9	370	24	A	a	DT
cord-320331-wtxja5i9	370	25	systematic	systematic	JJ
cord-320331-wtxja5i9	370	26	review	review	NN
cord-320331-wtxja5i9	370	27	of	of	IN
cord-320331-wtxja5i9	370	28	the	the	DT
cord-320331-wtxja5i9	370	29	literature	literature	NN
cord-320331-wtxja5i9	371	1	The	the	DT
cord-320331-wtxja5i9	371	2	cytokine	cytokine	NN
cord-320331-wtxja5i9	371	3	storm	storm	NN
cord-320331-wtxja5i9	371	4	of	of	IN
cord-320331-wtxja5i9	371	5	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	371	6	The	the	DT
cord-320331-wtxja5i9	371	7	formation	formation	NN
cord-320331-wtxja5i9	371	8	of	of	IN
cord-320331-wtxja5i9	371	9	microthrombi	microthrombi	NNP
cord-320331-wtxja5i9	371	10	in	in	IN
cord-320331-wtxja5i9	371	11	parenchymal	parenchymal	JJ
cord-320331-wtxja5i9	371	12	microvessels	microvessel	NNS
cord-320331-wtxja5i9	371	13	after	after	IN
cord-320331-wtxja5i9	371	14	traumatic	traumatic	JJ
cord-320331-wtxja5i9	371	15	brain	brain	NN
cord-320331-wtxja5i9	371	16	injury	injury	NN
cord-320331-wtxja5i9	371	17	is	be	VBZ
cord-320331-wtxja5i9	371	18	independent	independent	JJ
cord-320331-wtxja5i9	371	19	of	of	IN
cord-320331-wtxja5i9	371	20	coagulation	coagulation	NN
cord-320331-wtxja5i9	371	21	factor	factor	NN
cord-320331-wtxja5i9	371	22	XI	XI	NNP
cord-320331-wtxja5i9	371	23	Corticosteroids	Corticosteroids	NNPS
cord-320331-wtxja5i9	371	24	mediate	mediate	VBP
cord-320331-wtxja5i9	371	25	pro	pro	JJ
cord-320331-wtxja5i9	371	26	-	-	JJ
cord-320331-wtxja5i9	371	27	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	371	28	and	and	CC
cord-320331-wtxja5i9	371	29	anti	anti	JJ
cord-320331-wtxja5i9	371	30	-	-	JJ
cord-320331-wtxja5i9	371	31	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	371	32	pathways	pathway	NNS
cord-320331-wtxja5i9	371	33	directed	direct	VBN
cord-320331-wtxja5i9	371	34	at	at	IN
cord-320331-wtxja5i9	371	35	the	the	DT
cord-320331-wtxja5i9	371	36	aggravation	aggravation	NN
cord-320331-wtxja5i9	371	37	of	of	IN
cord-320331-wtxja5i9	371	38	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	371	39	Chronic	Chronic	NNP
cord-320331-wtxja5i9	371	40	mineralocorticoid	mineralocorticoid	NN
cord-320331-wtxja5i9	371	41	levels	level	NNS
cord-320331-wtxja5i9	371	42	are	be	VBP
cord-320331-wtxja5i9	371	43	thought	think	VBN
cord-320331-wtxja5i9	371	44	to	to	TO
cord-320331-wtxja5i9	371	45	cause	cause	VB
cord-320331-wtxja5i9	371	46	end	end	NN
cord-320331-wtxja5i9	371	47	-	-	HYPH
cord-320331-wtxja5i9	371	48	organ	organ	NN
cord-320331-wtxja5i9	371	49	damage	damage	NN
cord-320331-wtxja5i9	371	50	resulting	result	VBG
cord-320331-wtxja5i9	371	51	in	in	IN
cord-320331-wtxja5i9	371	52	hypertension	hypertension	NN
cord-320331-wtxja5i9	371	53	and	and	CC
cord-320331-wtxja5i9	371	54	end	end	NN
cord-320331-wtxja5i9	371	55	-	-	HYPH
cord-320331-wtxja5i9	371	56	organ	organ	NN
cord-320331-wtxja5i9	371	57	failure	failure	NN
cord-320331-wtxja5i9	371	58	.	.	.
cord-320331-wtxja5i9	372	1	Meanwhile	meanwhile	RB
cord-320331-wtxja5i9	372	2	,	,	,
cord-320331-wtxja5i9	372	3	glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	372	4	mediate	mediate	VBP
cord-320331-wtxja5i9	372	5	anti	anti	JJ
cord-320331-wtxja5i9	372	6	-	-	JJ
cord-320331-wtxja5i9	372	7	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	372	8	pathways	pathway	NNS
cord-320331-wtxja5i9	372	9	that	that	WDT
cord-320331-wtxja5i9	372	10	result	result	VBP
cord-320331-wtxja5i9	372	11	in	in	IN
cord-320331-wtxja5i9	372	12	the	the	DT
cord-320331-wtxja5i9	372	13	immunosuppressive	immunosuppressive	JJ
cord-320331-wtxja5i9	372	14	actions	action	NNS
cord-320331-wtxja5i9	372	15	of	of	IN
cord-320331-wtxja5i9	372	16	most	most	JJS
cord-320331-wtxja5i9	372	17	corticosteroid	corticosteroid	JJ
cord-320331-wtxja5i9	372	18	drugs	drug	NNS
cord-320331-wtxja5i9	372	19	in	in	IN
cord-320331-wtxja5i9	372	20	medicine	medicine	NN
cord-320331-wtxja5i9	372	21	.	.	.
cord-320331-wtxja5i9	373	1	Glucocorticoids	glucocorticoid	NNS
cord-320331-wtxja5i9	373	2	bind	bind	VBP
cord-320331-wtxja5i9	373	3	to	to	IN
cord-320331-wtxja5i9	373	4	their	-PRON-	PRP$
cord-320331-wtxja5i9	373	5	nuclear	nuclear	JJ
cord-320331-wtxja5i9	373	6	glucocorticoid	glucocorticoid	NN
cord-320331-wtxja5i9	373	7	receptors	receptor	NNS
cord-320331-wtxja5i9	373	8	(	(	-LRB-
cord-320331-wtxja5i9	373	9	GR	GR	NNP
cord-320331-wtxja5i9	373	10	)	)	-RRB-
cord-320331-wtxja5i9	373	11	,	,	,
cord-320331-wtxja5i9	373	12	but	but	CC
cord-320331-wtxja5i9	373	13	also	also	RB
cord-320331-wtxja5i9	373	14	to	to	IN
cord-320331-wtxja5i9	373	15	MR	MR	NNP
cord-320331-wtxja5i9	373	16	,	,	,
cord-320331-wtxja5i9	373	17	and	and	CC
cord-320331-wtxja5i9	373	18	affect	affect	VB
cord-320331-wtxja5i9	373	19	gene	gene	NN
cord-320331-wtxja5i9	373	20	transcription	transcription	NN
cord-320331-wtxja5i9	373	21	via	via	IN
cord-320331-wtxja5i9	373	22	two	two	CD
cord-320331-wtxja5i9	373	23	important	important	JJ
cord-320331-wtxja5i9	373	24	mechanisms	mechanism	NNS
cord-320331-wtxja5i9	373	25	:	:	:
cord-320331-wtxja5i9	373	26	(	(	-LRB-
cord-320331-wtxja5i9	373	27	1	1	LS
cord-320331-wtxja5i9	373	28	)	)	-RRB-
cord-320331-wtxja5i9	373	29	transactivation	transactivation	NN
cord-320331-wtxja5i9	373	30	,	,	,
cord-320331-wtxja5i9	373	31	which	which	WDT
cord-320331-wtxja5i9	373	32	is	be	VBZ
cord-320331-wtxja5i9	373	33	the	the	DT
cord-320331-wtxja5i9	373	34	direct	direct	JJ
cord-320331-wtxja5i9	373	35	interaction	interaction	NN
cord-320331-wtxja5i9	373	36	of	of	IN
cord-320331-wtxja5i9	373	37	the	the	DT
cord-320331-wtxja5i9	373	38	glucocorticoid	glucocorticoid	JJ
cord-320331-wtxja5i9	373	39	-	-	HYPH
cord-320331-wtxja5i9	373	40	GR	GR	NNP
cord-320331-wtxja5i9	373	41	complex	complex	NN
cord-320331-wtxja5i9	373	42	with	with	IN
cord-320331-wtxja5i9	373	43	genetic	genetic	JJ
cord-320331-wtxja5i9	373	44	material	material	NN
cord-320331-wtxja5i9	373	45	,	,	,
cord-320331-wtxja5i9	373	46	or	or	CC
cord-320331-wtxja5i9	373	47	(	(	-LRB-
cord-320331-wtxja5i9	373	48	2	2	LS
cord-320331-wtxja5i9	373	49	)	)	-RRB-
cord-320331-wtxja5i9	373	50	trans	trans	NN
cord-320331-wtxja5i9	373	51	-	-	NN
cord-320331-wtxja5i9	373	52	repression	repression	NN
cord-320331-wtxja5i9	373	53	,	,	,
cord-320331-wtxja5i9	373	54	in	in	IN
cord-320331-wtxja5i9	373	55	which	which	WDT
cord-320331-wtxja5i9	373	56	the	the	DT
cord-320331-wtxja5i9	373	57	complex	complex	NN
cord-320331-wtxja5i9	373	58	interacts	interact	VBZ
cord-320331-wtxja5i9	373	59	with	with	IN
cord-320331-wtxja5i9	373	60	other	other	JJ
cord-320331-wtxja5i9	373	61	proteins	protein	NNS
cord-320331-wtxja5i9	373	62	such	such	JJ
cord-320331-wtxja5i9	373	63	as	as	IN
cord-320331-wtxja5i9	373	64	CREB	CREB	NNP
cord-320331-wtxja5i9	373	65	-	-	HYPH
cord-320331-wtxja5i9	373	66	binding	bind	VBG
cord-320331-wtxja5i9	373	67	protein	protein	NN
cord-320331-wtxja5i9	373	68	(	(	-LRB-
cord-320331-wtxja5i9	373	69	CBP	CBP	NNP
cord-320331-wtxja5i9	373	70	)	)	-RRB-
cord-320331-wtxja5i9	373	71	and	and	CC
cord-320331-wtxja5i9	373	72	NF	nf	NN
cord-320331-wtxja5i9	373	73	-	-	HYPH
cord-320331-wtxja5i9	373	74	κB.	κb.	JJ
cord-320331-wtxja5i9	373	75	Trans	Trans	NNP
cord-320331-wtxja5i9	373	76	-	-	NN
cord-320331-wtxja5i9	373	77	activation	activation	NN
cord-320331-wtxja5i9	373	78	leads	lead	NNS
cord-320331-wtxja5i9	373	79	to	to	IN
cord-320331-wtxja5i9	373	80	an	an	DT
cord-320331-wtxja5i9	373	81	upregulation	upregulation	NN
cord-320331-wtxja5i9	373	82	of	of	IN
cord-320331-wtxja5i9	373	83	anti	anti	JJ
cord-320331-wtxja5i9	373	84	-	-	JJ
cord-320331-wtxja5i9	373	85	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	373	86	proteins	protein	NNS
cord-320331-wtxja5i9	373	87	,	,	,
cord-320331-wtxja5i9	373	88	while	while	IN
cord-320331-wtxja5i9	373	89	trans	trans	JJ
cord-320331-wtxja5i9	373	90	-	-	NN
cord-320331-wtxja5i9	373	91	repression	repression	NN
cord-320331-wtxja5i9	373	92	leads	lead	VBZ
cord-320331-wtxja5i9	373	93	to	to	IN
cord-320331-wtxja5i9	373	94	decreased	decrease	VBN
cord-320331-wtxja5i9	373	95	expression	expression	NN
cord-320331-wtxja5i9	373	96	of	of	IN
cord-320331-wtxja5i9	373	97	inflammatory	inflammatory	JJ
cord-320331-wtxja5i9	373	98	proteins	protein	NNS
cord-320331-wtxja5i9	373	99	.	.	.
cord-320331-wtxja5i9	374	1	Together	together	RB
cord-320331-wtxja5i9	374	2	,	,	,
cord-320331-wtxja5i9	374	3	these	these	DT
cord-320331-wtxja5i9	374	4	pathways	pathway	NNS
cord-320331-wtxja5i9	374	5	converge	converge	VBP
cord-320331-wtxja5i9	374	6	to	to	TO
cord-320331-wtxja5i9	374	7	result	result	VB
cord-320331-wtxja5i9	374	8	in	in	IN
cord-320331-wtxja5i9	374	9	immunosuppression	immunosuppression	NN
cord-320331-wtxja5i9	374	10	,	,	,
cord-320331-wtxja5i9	374	11	which	which	WDT
cord-320331-wtxja5i9	374	12	may	may	MD
cord-320331-wtxja5i9	374	13	aggravate	aggravate	VB
cord-320331-wtxja5i9	374	14	COVID-19	COVID-19	NNP
cord-320331-wtxja5i9	374	15	by	by	IN
cord-320331-wtxja5i9	374	16	promoting	promote	VBG
cord-320331-wtxja5i9	374	17	SARS	SARS	NNP
cord-320331-wtxja5i9	374	18	-	-	HYPH
cord-320331-wtxja5i9	374	19	CoV-2	CoV-2	NNP
cord-320331-wtxja5i9	374	20	replication	replication	NN
cord-320331-wtxja5i9	374	21	and	and	CC
cord-320331-wtxja5i9	374	22	shedding	shedding	NN
cord-320331-wtxja5i9	374	23	,	,	,
cord-320331-wtxja5i9	374	24	especially	especially	RB
cord-320331-wtxja5i9	374	25	in	in	IN
cord-320331-wtxja5i9	374	26	the	the	DT
cord-320331-wtxja5i9	374	27	early	early	JJ
cord-320331-wtxja5i9	374	28	stages	stage	NNS
cord-320331-wtxja5i9	374	29	of	of	IN
cord-320331-wtxja5i9	374	30	the	the	DT
cord-320331-wtxja5i9	374	31	disease	disease	NN