id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003586-afnto2tz	Baillet, Nicolas	Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses	2019-03-23		.txt	text/plain	7588	380	51	We identified host cellular proteins that interact with Z proteins of both viruses by using a high throughput yeast two-hybrid (HT-Y2H) screening protocol in which AH109 yeast cells were transformed with a Y2H vector encoding the Z protein of LASV or MOPV fused to the GAL4-BD domain (viral bait). Y2H screens allowed us to identify, among others, two known autophagy adaptors, namely NDP52 and TAX1BP1, which have been shown to interact with the Z protein of MOPV, but not LASV (Table 1) . Overall, these results suggest that NDP52 and TAX1BP1 are not involved in the production of infectious virus for either MOPV or LASV in HeLa cells. These results were unexpected and suggest that autophagy adaptors could play a role during LASV or MOPV infection that does not affect the viral fitness in the cell lines we used.	./cache/cord-003586-afnto2tz.txt	./txt/cord-003586-afnto2tz.txt