id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012497-n5pu1yeu	Rogers, Meredith C.	STAT2 Limits Host Species Specificity of Human Metapneumovirus	2020-07-04		.txt	text/plain	6400	333	53	Finally, we sought to understand the in vivo role of STAT2 by infecting hSTAT2 knock-in mice with HMPV, and found that mice had increased weight loss, inhibition of type I interferon signaling, and a Th2-polarized cytokine profile compared to WT mice. Mouse models for HMPV have been developed, but mice are only semi-permissive for HMPV, requiring a high viral inoculum for productive in vivo infection ( [25] and unpublished observations), which may be due to species differences in the innate immune proteins antagonized by the virus. To better understand the global consequences of substituting human STAT2 into mice in vivo, we performed multiplex cytokine analysis on lung homogenates of HMPV-infected hSTAT2 KI and WT mice at day five after high-dose inoculation, as day five represents a time point that bridges innate and adaptive immunity.	./cache/cord-012497-n5pu1yeu.txt	./txt/cord-012497-n5pu1yeu.txt