id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ni24u3psuvbs5nb2fztgr6z4ba	Tingting Shu	Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction	2019	12	.pdf	application/pdf	7301	699	49	level-induced increased iron deposition in β-cells and the relationship between abnormal tissue isolated from db/db mice, cultured islets and Min6 cells in response to high glucose excessive iron on mitochondrial function eventually resulted in impaired insulin secretion. role of hepcidin in the glucotoxcity impaired pancreatic β cell function pathway. on blood glucose levels by decreasing iron intake or Low hepcidin expression induces iron overload in Hepcidin content was analyzed in isolated islets using an ELISA method with different concentration of glucose treatment for 48 h. control, Ad-hepcidin, Ru 360 and iron chelator groups control, Ad-hepcidin, Ru 360 and iron chelator groups Effects of iron restriction on blood glucose levels and Min6 cells were infected with Ad-hepcidin or treated with RU 360 or an iron chelator plus 33.3 mM glucose. hepcidin expression in Min6 cells with 33.3 mM glucose Low hepcidin expression induces iron overload in pancreatic β-cells	./cache/work_ni24u3psuvbs5nb2fztgr6z4ba.pdf	./txt/work_ni24u3psuvbs5nb2fztgr6z4ba.txt