id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011251-rjyipcfv	Chernyshov, Vladimir V.	Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity	2019-02-28		.txt	text/plain	2781	151	45	title: Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity The present work is devoted to the synthesis of new polycyclic nitrogen-containing compounds from (+)-camphoric acid and aliphatic or aromatic diamines. Compounds 10a and 10b have been isolated after the column chromatography with a yield of 40% and 2%, Scheme 1 Interaction of camphoric acid with aliphatic diamines respectively. The quinazoline structure possibly imparts rigidity to the ligand and hence consistently high Scheme 2 Interaction of camphoric acid with aromatic diamines enantioselectivity [36] . We have previously shown that various derivatives of monoterpenoids, in particular compounds including a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold and N-heterocyclic fragment, exhibit antiviral properties against the influenza virus [39, 40] . It has been shown that compound 14 has inhibitory activity against different strains of influenza virus A. Enantioselective alkylation of aromatic aldehydes with (+)-camphoric acid derived chiral 1,3-diamine ligands	./cache/cord-011251-rjyipcfv.txt	./txt/cord-011251-rjyipcfv.txt