id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262643-wydc0wyd	Siebert, Agnieszka	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid	2018-01-01		.txt	text/plain	4093	239	47	The biological activity of the products was tested on five references bacterial strains: Klebsiella pneumoniae ATCC 700603 (ESBL), Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus MRSA ATCC 43300, Staphylococcus aureus MSSA ATCC 25923. We optimized synthesis of several new amino acid and peptide MPA derivatives by conjugation with various condensation reagents. Amino acid MPA derivatives 11e17 were obtained by means of a condensation reagent 1-ethyl-3-(3 0 -dimethylaminopropyl)carbodiimide (EDCI) in the presence of 4-(dimethylamino)pyridine (DMAP) acting as a base in anhydrous N,Ndimethylformamide (DMF) (Scheme 1). In case of derivatives of MPA with isoleucine 14 or malonate 17 moiety the best results were received using the T3P/Et 3 N procedure, where triethylamine acts as a base and propanephosphonic acid anhydride (T3P) is a condensing reagent (Scheme 2). Synthesis of amino acid derivatives of MPA 11e17 using the EDCI/DMAP method.	./cache/cord-262643-wydc0wyd.txt	./txt/cord-262643-wydc0wyd.txt