id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278654-dxx6z2fj	Wysocki, Jan	Reduced plasma ACE2 activity in dialysis patients: another piece in the conundrum of factors involved in hypertension and cardiovascular morbidity?	2013-06-19		.txt	text/plain	1774	98	43	the reduction in plasma ACE2 activity reported in ESRD patients treated by dialysis, particularly in female subjects, could limit Ang II degradation leading to increased levels of this peptide, which could contribute to the high prevalence of hypertension and cardiovascular morbidity that afflicts the dialysis population When compared with historic samples from healthy subjects, however, all CKD groups examined, i.e. predialysis, transplant patients and even subjects on dialysis, seemed to have increased levels of plasma ACE2 activity. What the study shows, in our opinion, is that while plasma ACE2 activity tends to increase in CKD patients, perhaps as a compensatory mechanism to attenuate Ang II overactivity, at the time that ESRD is reached and dialysis initiated a relative deficiency in plasma ACE2 activity ensues. This abnormally expressed endothelial protein could be shed into the circulation and could be the source of increased plasma ACE2 activity in certain conditions such as myocardial infarction, kidney disease or diabetes.	./cache/cord-278654-dxx6z2fj.txt	./txt/cord-278654-dxx6z2fj.txt