id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336578-5qzpd890	Sethiya, Jigar P.	MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections	2020-08-27		.txt	text/plain	13604	823	49	The increasing incidence, limited efficacy of current treatment options, and significant risk of drug-resistance in NTM infections suggest an urgent need for new antimycobacterial agents. Even though mycolic acids are found in all mycobacterial pathogens and provide similar cellular protection, structural integrity, and virulence, The increasing incidence, limited efficacy of current treatment options, and significant risk of drug-resistance in NTM infections suggest an urgent need for new antimycobacterial agents. Recently developed compounds targeting the MmpL3 transporter, a new and promiscuous target recognizing many structurally unique chemotypes, have proven to be effective in both TB and NTM infections. From the second series, the compound with the highest potency contained a cyclooctyl ring and 4,6-dimethyl indole (1, Table 1 ), having an activity ranging from 0.0039 to 0.6 µg/mL against RGM. From the second series, the compound with the highest potency contained a cyclooctyl ring and 4,6-dimethyl indole (1, Table 1 ), having an activity ranging from 0.0039 to 0.6 µg/mL against RGM.	./cache/cord-336578-5qzpd890.txt	./txt/cord-336578-5qzpd890.txt