id	sid	tid	token	lemma	pos
cord-300872-blycbi4u	1	1	key	key	JJ
cord-300872-blycbi4u	2	1	:	:	:
cord-300872-blycbi4u	2	2	cord-300872-blycbi4u	cord-300872-blycbi4u	NNS
cord-300872-blycbi4u	2	3	authors	author	NNS
cord-300872-blycbi4u	2	4	:	:	:
cord-300872-blycbi4u	2	5	Saadeh	Saadeh	NNP
cord-300872-blycbi4u	2	6	,	,	,
cord-300872-blycbi4u	2	7	Haythem	Haythem	NNP
cord-300872-blycbi4u	2	8	A.	a.	NN
cord-300872-blycbi4u	2	9	;	;	.
cord-300872-blycbi4u	3	1	Sweidan	Sweidan	NNP
cord-300872-blycbi4u	3	2	,	,	,
cord-300872-blycbi4u	3	3	Kamal	Kamal	NNP
cord-300872-blycbi4u	3	4	A.	a.	NN
cord-300872-blycbi4u	3	5	;	;	:
cord-300872-blycbi4u	3	6	Mubarak	Mubarak	NNP
cord-300872-blycbi4u	3	7	,	,	,
cord-300872-blycbi4u	3	8	Mohammad	Mohammad	NNP
cord-300872-blycbi4u	3	9	S.	S.	NNP
cord-300872-blycbi4u	3	10	title	title	NN
cord-300872-blycbi4u	3	11	:	:	:
cord-300872-blycbi4u	4	1	Recent	recent	JJ
cord-300872-blycbi4u	4	2	Advances	advance	NNS
cord-300872-blycbi4u	4	3	in	in	IN
cord-300872-blycbi4u	4	4	the	the	DT
cord-300872-blycbi4u	4	5	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	4	6	and	and	CC
cord-300872-blycbi4u	4	7	Biological	Biological	NNP
cord-300872-blycbi4u	4	8	Activity	Activity	NNP
cord-300872-blycbi4u	4	9	of	of	IN
cord-300872-blycbi4u	4	10	8-Hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	4	11	date	date	NN
cord-300872-blycbi4u	4	12	:	:	:
cord-300872-blycbi4u	4	13	2020	2020	CD
cord-300872-blycbi4u	4	14	-	-	HYPH
cord-300872-blycbi4u	4	15	09	09	CD
cord-300872-blycbi4u	4	16	-	-	SYM
cord-300872-blycbi4u	4	17	21	21	CD
cord-300872-blycbi4u	4	18	journal	journal	NN
cord-300872-blycbi4u	4	19	:	:	:
cord-300872-blycbi4u	5	1	Molecules	molecule	NNS
cord-300872-blycbi4u	5	2	DOI	DOI	NNP
cord-300872-blycbi4u	5	3	:	:	:
cord-300872-blycbi4u	6	1	10.3390	10.3390	CD
cord-300872-blycbi4u	6	2	/	/	SYM
cord-300872-blycbi4u	6	3	molecules25184321	molecules25184321	CD
cord-300872-blycbi4u	7	1	sha	sha	NNP
cord-300872-blycbi4u	7	2	:	:	:
cord-300872-blycbi4u	7	3	10dd8a023f0ea9fd04a0c3eebf0de6e3ee5daf89	10dd8a023f0ea9fd04a0c3eebf0de6e3ee5daf89	CD
cord-300872-blycbi4u	7	4	doc_id	doc_id	CD
cord-300872-blycbi4u	7	5	:	:	:
cord-300872-blycbi4u	8	1	300872	300872	CD
cord-300872-blycbi4u	8	2	cord_uid	cord_uid	NN
cord-300872-blycbi4u	8	3	:	:	:
cord-300872-blycbi4u	9	1	blycbi4u	blycbi4u	NNP
cord-300872-blycbi4u	9	2	Compounds	compound	NNS
cord-300872-blycbi4u	9	3	containing	contain	VBG
cord-300872-blycbi4u	9	4	the	the	DT
cord-300872-blycbi4u	9	5	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	9	6	(	(	-LRB-
cord-300872-blycbi4u	9	7	8-HQ	8-hq	CD
cord-300872-blycbi4u	9	8	)	)	-RRB-
cord-300872-blycbi4u	9	9	1	1	CD
cord-300872-blycbi4u	9	10	nucleus	nucleus	NN
cord-300872-blycbi4u	9	11	exhibit	exhibit	NN
cord-300872-blycbi4u	9	12	a	a	DT
cord-300872-blycbi4u	9	13	wide	wide	JJ
cord-300872-blycbi4u	9	14	range	range	NN
cord-300872-blycbi4u	9	15	of	of	IN
cord-300872-blycbi4u	9	16	biological	biological	JJ
cord-300872-blycbi4u	9	17	activities	activity	NNS
cord-300872-blycbi4u	9	18	,	,	,
cord-300872-blycbi4u	9	19	including	include	VBG
cord-300872-blycbi4u	9	20	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	9	21	,	,	,
cord-300872-blycbi4u	9	22	anticancer	anticancer	JJ
cord-300872-blycbi4u	9	23	,	,	,
cord-300872-blycbi4u	9	24	and	and	CC
cord-300872-blycbi4u	9	25	antifungal	antifungal	JJ
cord-300872-blycbi4u	9	26	effects	effect	NNS
cord-300872-blycbi4u	9	27	.	.	.
cord-300872-blycbi4u	10	1	The	the	DT
cord-300872-blycbi4u	10	2	chemistry	chemistry	NN
cord-300872-blycbi4u	10	3	and	and	CC
cord-300872-blycbi4u	10	4	biology	biology	NN
cord-300872-blycbi4u	10	5	of	of	IN
cord-300872-blycbi4u	10	6	this	this	DT
cord-300872-blycbi4u	10	7	group	group	NN
cord-300872-blycbi4u	10	8	have	have	VBP
cord-300872-blycbi4u	10	9	attracted	attract	VBN
cord-300872-blycbi4u	10	10	the	the	DT
cord-300872-blycbi4u	10	11	attention	attention	NN
cord-300872-blycbi4u	10	12	of	of	IN
cord-300872-blycbi4u	10	13	chemists	chemist	NNS
cord-300872-blycbi4u	10	14	,	,	,
cord-300872-blycbi4u	10	15	medicinal	medicinal	JJ
cord-300872-blycbi4u	10	16	chemists	chemist	NNS
cord-300872-blycbi4u	10	17	,	,	,
cord-300872-blycbi4u	10	18	and	and	CC
cord-300872-blycbi4u	10	19	professionals	professional	NNS
cord-300872-blycbi4u	10	20	in	in	IN
cord-300872-blycbi4u	10	21	health	health	NN
cord-300872-blycbi4u	10	22	sciences	science	NNS
cord-300872-blycbi4u	10	23	.	.	.
cord-300872-blycbi4u	11	1	A	a	DT
cord-300872-blycbi4u	11	2	number	number	NN
cord-300872-blycbi4u	11	3	of	of	IN
cord-300872-blycbi4u	11	4	prescribed	prescribe	VBN
cord-300872-blycbi4u	11	5	drugs	drug	NNS
cord-300872-blycbi4u	11	6	incorporate	incorporate	VBP
cord-300872-blycbi4u	11	7	this	this	DT
cord-300872-blycbi4u	11	8	group	group	NN
cord-300872-blycbi4u	11	9	,	,	,
cord-300872-blycbi4u	11	10	and	and	CC
cord-300872-blycbi4u	11	11	numerous	numerous	JJ
cord-300872-blycbi4u	11	12	8-HQ-	8-hq-	NN
cord-300872-blycbi4u	11	13	based	base	VBN
cord-300872-blycbi4u	11	14	molecules	molecule	NNS
cord-300872-blycbi4u	11	15	can	can	MD
cord-300872-blycbi4u	11	16	be	be	VB
cord-300872-blycbi4u	11	17	used	use	VBN
cord-300872-blycbi4u	11	18	to	to	TO
cord-300872-blycbi4u	11	19	develop	develop	VB
cord-300872-blycbi4u	11	20	potent	potent	JJ
cord-300872-blycbi4u	11	21	lead	lead	NN
cord-300872-blycbi4u	11	22	compounds	compound	NNS
cord-300872-blycbi4u	11	23	with	with	IN
cord-300872-blycbi4u	11	24	good	good	JJ
cord-300872-blycbi4u	11	25	efficacy	efficacy	NN
cord-300872-blycbi4u	11	26	and	and	CC
cord-300872-blycbi4u	11	27	low	low	JJ
cord-300872-blycbi4u	11	28	toxicity	toxicity	NN
cord-300872-blycbi4u	11	29	.	.	.
cord-300872-blycbi4u	12	1	This	this	DT
cord-300872-blycbi4u	12	2	review	review	NN
cord-300872-blycbi4u	12	3	focusses	focusse	VBZ
cord-300872-blycbi4u	12	4	on	on	IN
cord-300872-blycbi4u	12	5	the	the	DT
cord-300872-blycbi4u	12	6	recent	recent	JJ
cord-300872-blycbi4u	12	7	advances	advance	NNS
cord-300872-blycbi4u	12	8	in	in	IN
cord-300872-blycbi4u	12	9	the	the	DT
cord-300872-blycbi4u	12	10	synthesis	synthesis	NN
cord-300872-blycbi4u	12	11	of	of	IN
cord-300872-blycbi4u	12	12	8-HQ	8-hq	CD
cord-300872-blycbi4u	12	13	derivatives	derivative	NNS
cord-300872-blycbi4u	12	14	with	with	IN
cord-300872-blycbi4u	12	15	different	different	JJ
cord-300872-blycbi4u	12	16	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	12	17	properties	property	NNS
cord-300872-blycbi4u	12	18	,	,	,
cord-300872-blycbi4u	12	19	including	include	VBG
cord-300872-blycbi4u	12	20	anticancer	anticancer	JJ
cord-300872-blycbi4u	12	21	,	,	,
cord-300872-blycbi4u	12	22	antiviral	antiviral	JJ
cord-300872-blycbi4u	12	23	,	,	,
cord-300872-blycbi4u	12	24	and	and	CC
cord-300872-blycbi4u	12	25	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	12	26	activities	activity	NNS
cord-300872-blycbi4u	12	27	.	.	.
cord-300872-blycbi4u	13	1	For	for	IN
cord-300872-blycbi4u	13	2	this	this	DT
cord-300872-blycbi4u	13	3	purpose	purpose	NN
cord-300872-blycbi4u	13	4	,	,	,
cord-300872-blycbi4u	13	5	recent	recent	JJ
cord-300872-blycbi4u	13	6	relevant	relevant	JJ
cord-300872-blycbi4u	13	7	references	reference	NNS
cord-300872-blycbi4u	13	8	were	be	VBD
cord-300872-blycbi4u	13	9	searched	search	VBN
cord-300872-blycbi4u	13	10	in	in	IN
cord-300872-blycbi4u	13	11	different	different	JJ
cord-300872-blycbi4u	13	12	known	know	VBN
cord-300872-blycbi4u	13	13	databases	database	NNS
cord-300872-blycbi4u	13	14	and	and	CC
cord-300872-blycbi4u	13	15	search	search	NN
cord-300872-blycbi4u	13	16	engines	engine	NNS
cord-300872-blycbi4u	13	17	,	,	,
cord-300872-blycbi4u	13	18	such	such	JJ
cord-300872-blycbi4u	13	19	as	as	IN
cord-300872-blycbi4u	13	20	MEDLINE	MEDLINE	NNP
cord-300872-blycbi4u	13	21	(	(	-LRB-
cord-300872-blycbi4u	13	22	PubMed	PubMed	NNP
cord-300872-blycbi4u	13	23	)	)	-RRB-
cord-300872-blycbi4u	13	24	,	,	,
cord-300872-blycbi4u	13	25	Google	Google	NNP
cord-300872-blycbi4u	13	26	Scholar	Scholar	NNP
cord-300872-blycbi4u	13	27	,	,	,
cord-300872-blycbi4u	13	28	Science	Science	NNP
cord-300872-blycbi4u	13	29	Direct	Direct	NNP
cord-300872-blycbi4u	13	30	,	,	,
cord-300872-blycbi4u	13	31	Scopus	Scopus	NNP
cord-300872-blycbi4u	13	32	,	,	,
cord-300872-blycbi4u	13	33	Cochrane	Cochrane	NNP
cord-300872-blycbi4u	13	34	,	,	,
cord-300872-blycbi4u	13	35	Scientific	Scientific	NNP
cord-300872-blycbi4u	13	36	Information	Information	NNP
cord-300872-blycbi4u	13	37	Database	Database	NNP
cord-300872-blycbi4u	13	38	(	(	-LRB-
cord-300872-blycbi4u	13	39	SID	SID	NNP
cord-300872-blycbi4u	13	40	)	)	-RRB-
cord-300872-blycbi4u	13	41	,	,	,
cord-300872-blycbi4u	13	42	SciFinder	SciFinder	NNP
cord-300872-blycbi4u	13	43	,	,	,
cord-300872-blycbi4u	13	44	and	and	CC
cord-300872-blycbi4u	13	45	Institute	Institute	NNP
cord-300872-blycbi4u	13	46	for	for	IN
cord-300872-blycbi4u	13	47	Scientific	Scientific	NNP
cord-300872-blycbi4u	13	48	Information	Information	NNP
cord-300872-blycbi4u	13	49	(	(	-LRB-
cord-300872-blycbi4u	13	50	ISI	ISI	NNP
cord-300872-blycbi4u	13	51	)	)	-RRB-
cord-300872-blycbi4u	13	52	Web	web	NN
cord-300872-blycbi4u	13	53	of	of	IN
cord-300872-blycbi4u	13	54	Knowledge	Knowledge	NNP
cord-300872-blycbi4u	13	55	.	.	.
cord-300872-blycbi4u	14	1	This	this	DT
cord-300872-blycbi4u	14	2	review	review	NN
cord-300872-blycbi4u	14	3	article	article	NN
cord-300872-blycbi4u	14	4	provides	provide	VBZ
cord-300872-blycbi4u	14	5	a	a	DT
cord-300872-blycbi4u	14	6	literature	literature	NN
cord-300872-blycbi4u	14	7	overview	overview	NN
cord-300872-blycbi4u	14	8	of	of	IN
cord-300872-blycbi4u	14	9	the	the	DT
cord-300872-blycbi4u	14	10	various	various	JJ
cord-300872-blycbi4u	14	11	synthetic	synthetic	JJ
cord-300872-blycbi4u	14	12	strategies	strategy	NNS
cord-300872-blycbi4u	14	13	and	and	CC
cord-300872-blycbi4u	14	14	biological	biological	JJ
cord-300872-blycbi4u	14	15	activities	activity	NNS
cord-300872-blycbi4u	14	16	of	of	IN
cord-300872-blycbi4u	14	17	8-HQ	8-hq	CD
cord-300872-blycbi4u	14	18	derivatives	derivative	NNS
cord-300872-blycbi4u	14	19	and	and	CC
cord-300872-blycbi4u	14	20	covers	cover	VBZ
cord-300872-blycbi4u	14	21	the	the	DT
cord-300872-blycbi4u	14	22	recent	recent	JJ
cord-300872-blycbi4u	14	23	related	related	JJ
cord-300872-blycbi4u	14	24	literature	literature	NN
cord-300872-blycbi4u	14	25	.	.	.
cord-300872-blycbi4u	15	1	Taken	take	VBN
cord-300872-blycbi4u	15	2	together	together	RB
cord-300872-blycbi4u	15	3	,	,	,
cord-300872-blycbi4u	15	4	compounds	compound	NNS
cord-300872-blycbi4u	15	5	containing	contain	VBG
cord-300872-blycbi4u	15	6	the	the	DT
cord-300872-blycbi4u	15	7	8-HQ	8-hq	CD
cord-300872-blycbi4u	15	8	moiety	moiety	NN
cord-300872-blycbi4u	15	9	have	have	VBP
cord-300872-blycbi4u	15	10	huge	huge	JJ
cord-300872-blycbi4u	15	11	therapeutic	therapeutic	JJ
cord-300872-blycbi4u	15	12	value	value	NN
cord-300872-blycbi4u	15	13	and	and	CC
cord-300872-blycbi4u	15	14	can	can	MD
cord-300872-blycbi4u	15	15	act	act	VB
cord-300872-blycbi4u	15	16	as	as	IN
cord-300872-blycbi4u	15	17	potential	potential	JJ
cord-300872-blycbi4u	15	18	building	building	NN
cord-300872-blycbi4u	15	19	blocks	block	NNS
cord-300872-blycbi4u	15	20	for	for	IN
cord-300872-blycbi4u	15	21	various	various	JJ
cord-300872-blycbi4u	15	22	pharmacologically	pharmacologically	RB
cord-300872-blycbi4u	15	23	active	active	JJ
cord-300872-blycbi4u	15	24	scaffolds	scaffold	NNS
cord-300872-blycbi4u	15	25	.	.	.
cord-300872-blycbi4u	16	1	In	in	IN
cord-300872-blycbi4u	16	2	addition	addition	NN
cord-300872-blycbi4u	16	3	,	,	,
cord-300872-blycbi4u	16	4	several	several	JJ
cord-300872-blycbi4u	16	5	described	describe	VBN
cord-300872-blycbi4u	16	6	compounds	compound	NNS
cord-300872-blycbi4u	16	7	in	in	IN
cord-300872-blycbi4u	16	8	this	this	DT
cord-300872-blycbi4u	16	9	review	review	NN
cord-300872-blycbi4u	16	10	could	could	MD
cord-300872-blycbi4u	16	11	act	act	VB
cord-300872-blycbi4u	16	12	leads	lead	NNS
cord-300872-blycbi4u	16	13	for	for	IN
cord-300872-blycbi4u	16	14	the	the	DT
cord-300872-blycbi4u	16	15	development	development	NN
cord-300872-blycbi4u	16	16	of	of	IN
cord-300872-blycbi4u	16	17	drugs	drug	NNS
cord-300872-blycbi4u	16	18	against	against	IN
cord-300872-blycbi4u	16	19	numerous	numerous	JJ
cord-300872-blycbi4u	16	20	diseases	disease	NNS
cord-300872-blycbi4u	16	21	including	include	VBG
cord-300872-blycbi4u	16	22	cancer	cancer	NN
cord-300872-blycbi4u	16	23	.	.	.
cord-300872-blycbi4u	17	1	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	17	2	derivatives	derivative	NNS
cord-300872-blycbi4u	17	3	are	be	VBP
cord-300872-blycbi4u	17	4	an	an	DT
cord-300872-blycbi4u	17	5	important	important	JJ
cord-300872-blycbi4u	17	6	group	group	NN
cord-300872-blycbi4u	17	7	of	of	IN
cord-300872-blycbi4u	17	8	compounds	compound	NNS
cord-300872-blycbi4u	17	9	with	with	IN
cord-300872-blycbi4u	17	10	rich	rich	JJ
cord-300872-blycbi4u	17	11	and	and	CC
cord-300872-blycbi4u	17	12	diverse	diverse	JJ
cord-300872-blycbi4u	17	13	biological	biological	JJ
cord-300872-blycbi4u	17	14	activities	activity	NNS
cord-300872-blycbi4u	17	15	.	.	.
cord-300872-blycbi4u	18	1	These	these	DT
cord-300872-blycbi4u	18	2	compounds	compound	NNS
cord-300872-blycbi4u	18	3	incorporate	incorporate	VBP
cord-300872-blycbi4u	18	4	the	the	DT
cord-300872-blycbi4u	18	5	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	18	6	(	(	-LRB-
cord-300872-blycbi4u	18	7	8-HQ	8-hq	CD
cord-300872-blycbi4u	18	8	)	)	-RRB-
cord-300872-blycbi4u	18	9	moiety	moiety	NN
cord-300872-blycbi4u	18	10	,	,	,
cord-300872-blycbi4u	18	11	which	which	WDT
cord-300872-blycbi4u	18	12	is	be	VBZ
cord-300872-blycbi4u	18	13	a	a	DT
cord-300872-blycbi4u	18	14	bicyclic	bicyclic	JJ
cord-300872-blycbi4u	18	15	compound	compound	NN
cord-300872-blycbi4u	18	16	that	that	WDT
cord-300872-blycbi4u	18	17	consists	consist	VBZ
cord-300872-blycbi4u	18	18	of	of	IN
cord-300872-blycbi4u	18	19	a	a	DT
cord-300872-blycbi4u	18	20	pyridine	pyridine	NN
cord-300872-blycbi4u	18	21	ring	ring	NN
cord-300872-blycbi4u	18	22	fused	fuse	VBN
cord-300872-blycbi4u	18	23	to	to	IN
cord-300872-blycbi4u	18	24	phenol	phenol	NN
cord-300872-blycbi4u	18	25	,	,	,
cord-300872-blycbi4u	18	26	in	in	IN
cord-300872-blycbi4u	18	27	which	which	WDT
cord-300872-blycbi4u	18	28	the	the	DT
cord-300872-blycbi4u	18	29	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	18	30	group	group	NN
cord-300872-blycbi4u	18	31	is	be	VBZ
cord-300872-blycbi4u	18	32	attached	attach	VBN
cord-300872-blycbi4u	18	33	to	to	TO
cord-300872-blycbi4u	18	34	position	position	VB
cord-300872-blycbi4u	18	35	8	8	CD
cord-300872-blycbi4u	18	36	[	[	-LRB-
cord-300872-blycbi4u	18	37	1	1	CD
cord-300872-blycbi4u	18	38	]	]	-RRB-
cord-300872-blycbi4u	18	39	.	.	.
cord-300872-blycbi4u	19	1	In	in	IN
cord-300872-blycbi4u	19	2	this	this	DT
cord-300872-blycbi4u	19	3	respect	respect	NN
cord-300872-blycbi4u	19	4	,	,	,
cord-300872-blycbi4u	19	5	the	the	DT
cord-300872-blycbi4u	19	6	pyridine	pyridine	NN
cord-300872-blycbi4u	19	7	ring	ring	NN
cord-300872-blycbi4u	19	8	maintains	maintain	VBZ
cord-300872-blycbi4u	19	9	its	-PRON-	PRP$
cord-300872-blycbi4u	19	10	properties	property	NNS
cord-300872-blycbi4u	19	11	as	as	IN
cord-300872-blycbi4u	19	12	an	an	DT
cord-300872-blycbi4u	19	13	electron	electron	NN
cord-300872-blycbi4u	19	14	-	-	HYPH
cord-300872-blycbi4u	19	15	deficient	deficient	JJ
cord-300872-blycbi4u	19	16	entity	entity	NN
cord-300872-blycbi4u	19	17	with	with	IN
cord-300872-blycbi4u	19	18	a	a	DT
cord-300872-blycbi4u	19	19	basic	basic	JJ
cord-300872-blycbi4u	19	20	nitrogen	nitrogen	NN
cord-300872-blycbi4u	19	21	.	.	.
cord-300872-blycbi4u	20	1	In	in	IN
cord-300872-blycbi4u	20	2	addition	addition	NN
cord-300872-blycbi4u	20	3	,	,	,
cord-300872-blycbi4u	20	4	and	and	CC
cord-300872-blycbi4u	20	5	due	due	IN
cord-300872-blycbi4u	20	6	to	to	IN
cord-300872-blycbi4u	20	7	the	the	DT
cord-300872-blycbi4u	20	8	presence	presence	NN
cord-300872-blycbi4u	20	9	of	of	IN
cord-300872-blycbi4u	20	10	the	the	DT
cord-300872-blycbi4u	20	11	phenolic	phenolic	JJ
cord-300872-blycbi4u	20	12	group	group	NN
cord-300872-blycbi4u	20	13	,	,	,
cord-300872-blycbi4u	20	14	8-HQ	8-hq	CD
cord-300872-blycbi4u	20	15	displays	display	VBZ
cord-300872-blycbi4u	20	16	typical	typical	JJ
cord-300872-blycbi4u	20	17	phenolic	phenolic	JJ
cord-300872-blycbi4u	20	18	properties	property	NNS
cord-300872-blycbi4u	20	19	that	that	WDT
cord-300872-blycbi4u	20	20	make	make	VBP
cord-300872-blycbi4u	20	21	it	-PRON-	PRP
cord-300872-blycbi4u	20	22	susceptible	susceptible	JJ
cord-300872-blycbi4u	20	23	to	to	IN
cord-300872-blycbi4u	20	24	numerous	numerous	JJ
cord-300872-blycbi4u	20	25	chemical	chemical	JJ
cord-300872-blycbi4u	20	26	reactions	reaction	NNS
cord-300872-blycbi4u	20	27	and	and	CC
cord-300872-blycbi4u	20	28	structural	structural	JJ
cord-300872-blycbi4u	20	29	modifications	modification	NNS
cord-300872-blycbi4u	20	30	,	,	,
cord-300872-blycbi4u	20	31	such	such	JJ
cord-300872-blycbi4u	20	32	as	as	IN
cord-300872-blycbi4u	20	33	electrophilic	electrophilic	JJ
cord-300872-blycbi4u	20	34	aromatic	aromatic	JJ
cord-300872-blycbi4u	20	35	substitution	substitution	NN
cord-300872-blycbi4u	20	36	,	,	,
cord-300872-blycbi4u	20	37	diazonium	diazonium	JJ
cord-300872-blycbi4u	20	38	coupling	coupling	NN
cord-300872-blycbi4u	20	39	,	,	,
cord-300872-blycbi4u	20	40	and	and	CC
cord-300872-blycbi4u	20	41	molecular	molecular	JJ
cord-300872-blycbi4u	20	42	rearrangements	rearrangement	NNS
cord-300872-blycbi4u	20	43	.	.	.
cord-300872-blycbi4u	21	1	The	the	DT
cord-300872-blycbi4u	21	2	close	close	JJ
cord-300872-blycbi4u	21	3	proximity	proximity	NN
cord-300872-blycbi4u	21	4	of	of	IN
cord-300872-blycbi4u	21	5	the	the	DT
cord-300872-blycbi4u	21	6	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	21	7	group	group	NN
cord-300872-blycbi4u	21	8	to	to	IN
cord-300872-blycbi4u	21	9	the	the	DT
cord-300872-blycbi4u	21	10	heterocyclic	heterocyclic	NN
cord-300872-blycbi4u	21	11	nitrogen	nitrogen	NN
cord-300872-blycbi4u	21	12	makes	make	VBZ
cord-300872-blycbi4u	21	13	8-hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	21	14	good	good	JJ
cord-300872-blycbi4u	21	15	monoprotic	monoprotic	JJ
cord-300872-blycbi4u	21	16	bidentate	bidentate	JJ
cord-300872-blycbi4u	21	17	chelating	chelating	JJ
cord-300872-blycbi4u	21	18	agents	agent	NNS
cord-300872-blycbi4u	21	19	,	,	,
cord-300872-blycbi4u	21	20	which	which	WDT
cord-300872-blycbi4u	21	21	form	form	VBP
cord-300872-blycbi4u	21	22	four	four	CD
cord-300872-blycbi4u	21	23	-	-	HYPH
cord-300872-blycbi4u	21	24	and	and	CC
cord-300872-blycbi4u	21	25	six	six	CD
cord-300872-blycbi4u	21	26	-	-	HYPH
cord-300872-blycbi4u	21	27	covalent	covalent	JJ
cord-300872-blycbi4u	21	28	complexes	complex	NNS
cord-300872-blycbi4u	21	29	with	with	IN
cord-300872-blycbi4u	21	30	a	a	DT
cord-300872-blycbi4u	21	31	wide	wide	JJ
cord-300872-blycbi4u	21	32	range	range	NN
cord-300872-blycbi4u	21	33	of	of	IN
cord-300872-blycbi4u	21	34	metal	metal	NN
cord-300872-blycbi4u	21	35	ions	ion	NNS
cord-300872-blycbi4u	21	36	,	,	,
cord-300872-blycbi4u	21	37	including	include	VBG
cord-300872-blycbi4u	21	38	Cu	cu	NN
cord-300872-blycbi4u	21	39	2	2	CD
cord-300872-blycbi4u	22	1	+	+	CC
cord-300872-blycbi4u	22	2	,	,	,
cord-300872-blycbi4u	22	3	Zn	Zn	NNP
cord-300872-blycbi4u	22	4	2	2	CD
cord-300872-blycbi4u	23	1	+	+	CC
cord-300872-blycbi4u	24	1	,	,	,
cord-300872-blycbi4u	24	2	Bi	Bi	NNP
cord-300872-blycbi4u	24	3	2	2	CD
cord-300872-blycbi4u	24	4	+	+	SYM
cord-300872-blycbi4u	24	5	,	,	,
cord-300872-blycbi4u	24	6	Mn	Mn	NNP
cord-300872-blycbi4u	24	7	2	2	CD
cord-300872-blycbi4u	25	1	+	+	UH
cord-300872-blycbi4u	25	2	,	,	.
cord-300872-blycbi4u	26	1	Mg	Mg	NNP
cord-300872-blycbi4u	26	2	2	2	CD
cord-300872-blycbi4u	26	3	+	+	SYM
cord-300872-blycbi4u	26	4	,	,	,
cord-300872-blycbi4u	26	5	Cd	Cd	NNP
cord-300872-blycbi4u	26	6	2	2	CD
cord-300872-blycbi4u	27	1	+	+	UH
cord-300872-blycbi4u	27	2	,	,	,
cord-300872-blycbi4u	27	3	Ni	Ni	NNP
cord-300872-blycbi4u	27	4	2	2	CD
cord-300872-blycbi4u	27	5	+	+	CC
cord-300872-blycbi4u	28	1	,	,	,
cord-300872-blycbi4u	28	2	Fe	Fe	NNP
cord-300872-blycbi4u	28	3	3	3	CD
cord-300872-blycbi4u	28	4	+	+	CC
cord-300872-blycbi4u	28	5	,	,	,
cord-300872-blycbi4u	28	6	and	and	CC
cord-300872-blycbi4u	28	7	Al	Al	NNP
cord-300872-blycbi4u	28	8	3	3	CD
cord-300872-blycbi4u	29	1	+	+	CC
cord-300872-blycbi4u	29	2	[	[	-LRB-
cord-300872-blycbi4u	29	3	2	2	CD
cord-300872-blycbi4u	29	4	]	]	-RRB-
cord-300872-blycbi4u	29	5	.	.	.
cord-300872-blycbi4u	30	1	Figure	figure	NN
cord-300872-blycbi4u	30	2	1	1	CD
cord-300872-blycbi4u	30	3	is	be	VBZ
cord-300872-blycbi4u	30	4	a	a	DT
cord-300872-blycbi4u	30	5	schematic	schematic	JJ
cord-300872-blycbi4u	30	6	representation	representation	NN
cord-300872-blycbi4u	30	7	of	of	IN
cord-300872-blycbi4u	30	8	the	the	DT
cord-300872-blycbi4u	30	9	different	different	JJ
cord-300872-blycbi4u	30	10	sites	site	NNS
cord-300872-blycbi4u	30	11	of	of	IN
cord-300872-blycbi4u	30	12	reactions	reaction	NNS
cord-300872-blycbi4u	30	13	of	of	IN
cord-300872-blycbi4u	30	14	8-HQ	8-hq	CD
cord-300872-blycbi4u	30	15	.	.	.
cord-300872-blycbi4u	31	1	All	all	DT
cord-300872-blycbi4u	31	2	of	of	IN
cord-300872-blycbi4u	31	3	the	the	DT
cord-300872-blycbi4u	31	4	aforementioned	aforementioned	JJ
cord-300872-blycbi4u	31	5	properties	property	NNS
cord-300872-blycbi4u	31	6	make	make	VBP
cord-300872-blycbi4u	31	7	8-HQ	8-hq	CD
cord-300872-blycbi4u	31	8	a	a	DT
cord-300872-blycbi4u	31	9	privileged	privileged	JJ
cord-300872-blycbi4u	31	10	structure	structure	NN
cord-300872-blycbi4u	31	11	with	with	IN
cord-300872-blycbi4u	31	12	a	a	DT
cord-300872-blycbi4u	31	13	variety	variety	NN
cord-300872-blycbi4u	31	14	of	of	IN
cord-300872-blycbi4u	31	15	structural	structural	JJ
cord-300872-blycbi4u	31	16	modifications	modification	NNS
cord-300872-blycbi4u	31	17	,	,	,
cord-300872-blycbi4u	31	18	possessing	possess	VBG
cord-300872-blycbi4u	31	19	a	a	DT
cord-300872-blycbi4u	31	20	rich	rich	JJ
cord-300872-blycbi4u	31	21	diversity	diversity	NN
cord-300872-blycbi4u	31	22	of	of	IN
cord-300872-blycbi4u	31	23	physical	physical	JJ
cord-300872-blycbi4u	31	24	,	,	,
cord-300872-blycbi4u	31	25	chemical	chemical	NN
cord-300872-blycbi4u	31	26	and	and	CC
cord-300872-blycbi4u	31	27	biological	biological	JJ
cord-300872-blycbi4u	31	28	properties	property	NNS
cord-300872-blycbi4u	31	29	.	.	.
cord-300872-blycbi4u	32	1	8-Hydroxyquinoline	8-Hydroxyquinoline	NNP
cord-300872-blycbi4u	32	2	has	have	VBZ
cord-300872-blycbi4u	32	3	attracted	attract	VBN
cord-300872-blycbi4u	32	4	the	the	DT
cord-300872-blycbi4u	32	5	attention	attention	NN
cord-300872-blycbi4u	32	6	of	of	IN
cord-300872-blycbi4u	32	7	chemists	chemist	NNS
cord-300872-blycbi4u	32	8	,	,	,
cord-300872-blycbi4u	32	9	medicinal	medicinal	JJ
cord-300872-blycbi4u	32	10	chemists	chemist	NNS
cord-300872-blycbi4u	32	11	,	,	,
cord-300872-blycbi4u	32	12	and	and	CC
cord-300872-blycbi4u	32	13	people	people	NNS
cord-300872-blycbi4u	32	14	in	in	IN
cord-300872-blycbi4u	32	15	health	health	NN
cord-300872-blycbi4u	32	16	sciences	science	NNS
cord-300872-blycbi4u	32	17	due	due	IN
cord-300872-blycbi4u	32	18	to	to	IN
cord-300872-blycbi4u	32	19	its	-PRON-	PRP$
cord-300872-blycbi4u	32	20	unique	unique	JJ
cord-300872-blycbi4u	32	21	physical	physical	JJ
cord-300872-blycbi4u	32	22	and	and	CC
cord-300872-blycbi4u	32	23	chemical	chemical	JJ
cord-300872-blycbi4u	32	24	properties	property	NNS
cord-300872-blycbi4u	32	25	.	.	.
cord-300872-blycbi4u	33	1	The	the	DT
cord-300872-blycbi4u	33	2	interest	interest	NN
cord-300872-blycbi4u	33	3	in	in	IN
cord-300872-blycbi4u	33	4	this	this	DT
cord-300872-blycbi4u	33	5	compound	compound	NN
cord-300872-blycbi4u	33	6	and	and	CC
cord-300872-blycbi4u	33	7	its	-PRON-	PRP$
cord-300872-blycbi4u	33	8	derivatives	derivative	NNS
cord-300872-blycbi4u	33	9	has	have	VBZ
cord-300872-blycbi4u	33	10	increased	increase	VBN
cord-300872-blycbi4u	33	11	considerably	considerably	RB
cord-300872-blycbi4u	33	12	in	in	IN
cord-300872-blycbi4u	33	13	the	the	DT
cord-300872-blycbi4u	33	14	last	last	JJ
cord-300872-blycbi4u	33	15	two	two	CD
cord-300872-blycbi4u	33	16	decades	decade	NNS
cord-300872-blycbi4u	33	17	[	[	-LRB-
cord-300872-blycbi4u	33	18	3	3	CD
cord-300872-blycbi4u	33	19	]	]	-RRB-
cord-300872-blycbi4u	33	20	.	.	.
cord-300872-blycbi4u	34	1	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	34	2	and	and	CC
cord-300872-blycbi4u	34	3	many	many	JJ
cord-300872-blycbi4u	34	4	of	of	IN
cord-300872-blycbi4u	34	5	its	-PRON-	PRP$
cord-300872-blycbi4u	34	6	derivatives	derivative	NNS
cord-300872-blycbi4u	34	7	have	have	VBP
cord-300872-blycbi4u	34	8	a	a	DT
cord-300872-blycbi4u	34	9	wide	wide	JJ
cord-300872-blycbi4u	34	10	range	range	NN
cord-300872-blycbi4u	34	11	of	of	IN
cord-300872-blycbi4u	34	12	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	34	13	applications	application	NNS
cord-300872-blycbi4u	34	14	,	,	,
cord-300872-blycbi4u	34	15	e.g.	e.g.	RB
cord-300872-blycbi4u	34	16	,	,	,
cord-300872-blycbi4u	34	17	as	as	IN
cord-300872-blycbi4u	34	18	iron	iron	NN
cord-300872-blycbi4u	34	19	-	-	HYPH
cord-300872-blycbi4u	34	20	chelators	chelator	NNS
cord-300872-blycbi4u	34	21	for	for	IN
cord-300872-blycbi4u	34	22	neuroprotection	neuroprotection	NN
cord-300872-blycbi4u	34	23	,	,	,
cord-300872-blycbi4u	34	24	as	as	IN
cord-300872-blycbi4u	34	25	anticancer	anticancer	JJ
cord-300872-blycbi4u	34	26	agents	agent	NNS
cord-300872-blycbi4u	34	27	,	,	,
cord-300872-blycbi4u	34	28	as	as	IN
cord-300872-blycbi4u	34	29	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	34	30	of	of	IN
cord-300872-blycbi4u	34	31	2OG	2og	CD
cord-300872-blycbi4u	34	32	-	-	HYPH
cord-300872-blycbi4u	34	33	dependent	dependent	JJ
cord-300872-blycbi4u	34	34	enzymes	enzyme	NNS
cord-300872-blycbi4u	34	35	,	,	,
cord-300872-blycbi4u	34	36	as	as	IN
cord-300872-blycbi4u	34	37	chelators	chelator	NNS
cord-300872-blycbi4u	34	38	of	of	IN
cord-300872-blycbi4u	34	39	metalloproteins	metalloproteins	NNP
cord-300872-blycbi4u	34	40	,	,	,
cord-300872-blycbi4u	34	41	as	as	IN
cord-300872-blycbi4u	34	42	anti	anti	JJ
cord-300872-blycbi4u	34	43	-	-	JJ
cord-300872-blycbi4u	34	44	HIV	hiv	JJ
cord-300872-blycbi4u	34	45	agents	agent	NNS
cord-300872-blycbi4u	34	46	,	,	,
cord-300872-blycbi4u	34	47	as	as	IN
cord-300872-blycbi4u	34	48	antifungal	antifungal	JJ
cord-300872-blycbi4u	34	49	agents	agent	NNS
cord-300872-blycbi4u	34	50	,	,	,
cord-300872-blycbi4u	34	51	as	as	IN
cord-300872-blycbi4u	34	52	antileishmanial	antileishmanial	NNP
cord-300872-blycbi4u	34	53	agents	agent	NNS
cord-300872-blycbi4u	34	54	,	,	,
cord-300872-blycbi4u	34	55	as	as	IN
cord-300872-blycbi4u	34	56	antischistosomal	antischistosomal	NNP
cord-300872-blycbi4u	34	57	agents	agent	NNS
cord-300872-blycbi4u	34	58	,	,	,
cord-300872-blycbi4u	34	59	as	as	IN
cord-300872-blycbi4u	34	60	mycobacterium	mycobacterium	NNP
cord-300872-blycbi4u	34	61	tuberculosis	tuberculosis	NN
cord-300872-blycbi4u	34	62	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	34	63	,	,	,
cord-300872-blycbi4u	34	64	and	and	CC
cord-300872-blycbi4u	34	65	as	as	IN
cord-300872-blycbi4u	34	66	botulinum	botulinum	NN
cord-300872-blycbi4u	34	67	neurotoxin	neurotoxin	NN
cord-300872-blycbi4u	34	68	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	34	69	[	[	-LRB-
cord-300872-blycbi4u	34	70	4	4	CD
cord-300872-blycbi4u	34	71	]	]	-RRB-
cord-300872-blycbi4u	34	72	.	.	.
cord-300872-blycbi4u	35	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	35	2	,	,	,
cord-300872-blycbi4u	35	3	these	these	DT
cord-300872-blycbi4u	35	4	compounds	compound	NNS
cord-300872-blycbi4u	35	5	are	be	VBP
cord-300872-blycbi4u	35	6	used	use	VBN
cord-300872-blycbi4u	35	7	as	as	IN
cord-300872-blycbi4u	35	8	electron	electron	NN
cord-300872-blycbi4u	35	9	carriers	carrier	NNS
cord-300872-blycbi4u	35	10	in	in	IN
cord-300872-blycbi4u	35	11	organic	organic	JJ
cord-300872-blycbi4u	35	12	light	light	NN
cord-300872-blycbi4u	35	13	-	-	HYPH
cord-300872-blycbi4u	35	14	emitting	emit	VBG
cord-300872-blycbi4u	35	15	diodes	diode	NNS
cord-300872-blycbi4u	35	16	(	(	-LRB-
cord-300872-blycbi4u	35	17	OLEDs	OLEDs	NNP
cord-300872-blycbi4u	35	18	)	)	-RRB-
cord-300872-blycbi4u	35	19	and	and	CC
cord-300872-blycbi4u	35	20	as	as	IN
cord-300872-blycbi4u	35	21	fluorescent	fluorescent	JJ
cord-300872-blycbi4u	35	22	chemosensors	chemosensor	NNS
cord-300872-blycbi4u	35	23	for	for	IN
cord-300872-blycbi4u	35	24	metal	metal	NN
cord-300872-blycbi4u	35	25	ions	ion	NNS
cord-300872-blycbi4u	35	26	[	[	-LRB-
cord-300872-blycbi4u	35	27	5	5	CD
cord-300872-blycbi4u	35	28	,	,	,
cord-300872-blycbi4u	35	29	6	6	CD
cord-300872-blycbi4u	35	30	]	]	-RRB-
cord-300872-blycbi4u	35	31	.	.	.
cord-300872-blycbi4u	36	1	On	on	IN
cord-300872-blycbi4u	36	2	the	the	DT
cord-300872-blycbi4u	36	3	basis	basis	NN
cord-300872-blycbi4u	36	4	of	of	IN
cord-300872-blycbi4u	36	5	the	the	DT
cord-300872-blycbi4u	36	6	preceding	precede	VBG
cord-300872-blycbi4u	36	7	discussion	discussion	NN
cord-300872-blycbi4u	36	8	,	,	,
cord-300872-blycbi4u	36	9	and	and	CC
cord-300872-blycbi4u	36	10	owing	owe	VBG
cord-300872-blycbi4u	36	11	to	to	IN
cord-300872-blycbi4u	36	12	the	the	DT
cord-300872-blycbi4u	36	13	importance	importance	NN
cord-300872-blycbi4u	36	14	of	of	IN
cord-300872-blycbi4u	36	15	8-HQ	8-hq	CD
cord-300872-blycbi4u	36	16	from	from	IN
cord-300872-blycbi4u	36	17	a	a	DT
cord-300872-blycbi4u	36	18	chemistry	chemistry	NN
cord-300872-blycbi4u	36	19	point	point	NN
cord-300872-blycbi4u	36	20	of	of	IN
cord-300872-blycbi4u	36	21	view	view	NN
cord-300872-blycbi4u	36	22	and	and	CC
cord-300872-blycbi4u	36	23	to	to	IN
cord-300872-blycbi4u	36	24	the	the	DT
cord-300872-blycbi4u	36	25	wide	wide	JJ
cord-300872-blycbi4u	36	26	range	range	NN
cord-300872-blycbi4u	36	27	of	of	IN
cord-300872-blycbi4u	36	28	biological	biological	JJ
cord-300872-blycbi4u	36	29	activities	activity	NNS
cord-300872-blycbi4u	36	30	and	and	CC
cord-300872-blycbi4u	36	31	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	36	32	applications	application	NNS
cord-300872-blycbi4u	36	33	of	of	IN
cord-300872-blycbi4u	36	34	8-HQ	8-hq	CD
cord-300872-blycbi4u	36	35	and	and	CC
cord-300872-blycbi4u	36	36	derivatives	derivative	NNS
cord-300872-blycbi4u	36	37	,	,	,
cord-300872-blycbi4u	36	38	this	this	DT
cord-300872-blycbi4u	36	39	review	review	NN
cord-300872-blycbi4u	36	40	focuses	focus	VBZ
cord-300872-blycbi4u	36	41	on	on	IN
cord-300872-blycbi4u	36	42	current	current	JJ
cord-300872-blycbi4u	36	43	knowledge	knowledge	NN
cord-300872-blycbi4u	36	44	of	of	IN
cord-300872-blycbi4u	36	45	the	the	DT
cord-300872-blycbi4u	36	46	synthetic	synthetic	JJ
cord-300872-blycbi4u	36	47	methods	method	NNS
cord-300872-blycbi4u	36	48	of	of	IN
cord-300872-blycbi4u	36	49	novel	novel	JJ
cord-300872-blycbi4u	36	50	derivatives	derivative	NNS
cord-300872-blycbi4u	36	51	,	,	,
cord-300872-blycbi4u	36	52	along	along	IN
cord-300872-blycbi4u	36	53	with	with	IN
cord-300872-blycbi4u	36	54	the	the	DT
cord-300872-blycbi4u	36	55	derivatives	derivative	NNS
cord-300872-blycbi4u	36	56	'	'	POS
cord-300872-blycbi4u	36	57	biological	biological	JJ
cord-300872-blycbi4u	36	58	activities	activity	NNS
cord-300872-blycbi4u	36	59	and	and	CC
cord-300872-blycbi4u	36	60	medicinal	medicinal	JJ
cord-300872-blycbi4u	36	61	applications	application	NNS
cord-300872-blycbi4u	36	62	.	.	.
cord-300872-blycbi4u	37	1	In	in	IN
cord-300872-blycbi4u	37	2	addition	addition	NN
cord-300872-blycbi4u	37	3	,	,	,
cord-300872-blycbi4u	37	4	this	this	DT
cord-300872-blycbi4u	37	5	review	review	NN
cord-300872-blycbi4u	37	6	summarizes	summarize	VBZ
cord-300872-blycbi4u	37	7	the	the	DT
cord-300872-blycbi4u	37	8	most	most	RBS
cord-300872-blycbi4u	37	9	recent	recent	JJ
cord-300872-blycbi4u	37	10	literature	literature	NN
cord-300872-blycbi4u	37	11	pertaining	pertain	VBG
cord-300872-blycbi4u	37	12	to	to	IN
cord-300872-blycbi4u	37	13	the	the	DT
cord-300872-blycbi4u	37	14	synthesis	synthesis	NN
cord-300872-blycbi4u	37	15	and	and	CC
cord-300872-blycbi4u	37	16	bioactivity	bioactivity	NN
cord-300872-blycbi4u	37	17	of	of	IN
cord-300872-blycbi4u	37	18	8-HQ	8-hq	CD
cord-300872-blycbi4u	37	19	and	and	CC
cord-300872-blycbi4u	37	20	its	-PRON-	PRP$
cord-300872-blycbi4u	37	21	derivatives	derivative	NNS
cord-300872-blycbi4u	37	22	,	,	,
cord-300872-blycbi4u	37	23	covering	cover	VBG
cord-300872-blycbi4u	37	24	the	the	DT
cord-300872-blycbi4u	37	25	period	period	NN
cord-300872-blycbi4u	37	26	ranging	range	VBG
cord-300872-blycbi4u	37	27	from	from	IN
cord-300872-blycbi4u	37	28	2017	2017	CD
cord-300872-blycbi4u	37	29	to	to	IN
cord-300872-blycbi4u	37	30	the	the	DT
cord-300872-blycbi4u	37	31	present	present	NN
cord-300872-blycbi4u	37	32	.	.	.
cord-300872-blycbi4u	38	1	In	in	IN
cord-300872-blycbi4u	38	2	addition	addition	NN
cord-300872-blycbi4u	38	3	,	,	,
cord-300872-blycbi4u	38	4	structure	structure	NN
cord-300872-blycbi4u	38	5	-	-	HYPH
cord-300872-blycbi4u	38	6	activity	activity	NN
cord-300872-blycbi4u	38	7	relationships	relationship	NNS
cord-300872-blycbi4u	38	8	(	(	-LRB-
cord-300872-blycbi4u	38	9	SARs	SARs	NNP
cord-300872-blycbi4u	38	10	)	)	-RRB-
cord-300872-blycbi4u	38	11	of	of	IN
cord-300872-blycbi4u	38	12	these	these	DT
cord-300872-blycbi4u	38	13	derivatives	derivative	NNS
cord-300872-blycbi4u	38	14	are	be	VBP
cord-300872-blycbi4u	38	15	discussed	discuss	VBN
cord-300872-blycbi4u	38	16	to	to	TO
cord-300872-blycbi4u	38	17	provide	provide	VB
cord-300872-blycbi4u	38	18	directions	direction	NNS
cord-300872-blycbi4u	38	19	for	for	IN
cord-300872-blycbi4u	38	20	further	further	JJ
cord-300872-blycbi4u	38	21	development	development	NN
cord-300872-blycbi4u	38	22	of	of	IN
cord-300872-blycbi4u	38	23	novel	novel	JJ
cord-300872-blycbi4u	38	24	8-HQ	8-hq	CD
cord-300872-blycbi4u	38	25	-	-	HYPH
cord-300872-blycbi4u	38	26	based	base	VBN
cord-300872-blycbi4u	38	27	bioactive	bioactive	JJ
cord-300872-blycbi4u	38	28	agents	agent	NNS
cord-300872-blycbi4u	38	29	.	.	.
cord-300872-blycbi4u	39	1	For	for	IN
cord-300872-blycbi4u	39	2	this	this	DT
cord-300872-blycbi4u	39	3	purpose	purpose	NN
cord-300872-blycbi4u	39	4	,	,	,
cord-300872-blycbi4u	39	5	recent	recent	JJ
cord-300872-blycbi4u	39	6	relevant	relevant	JJ
cord-300872-blycbi4u	39	7	references	reference	NNS
cord-300872-blycbi4u	39	8	have	have	VBP
cord-300872-blycbi4u	39	9	been	be	VBN
cord-300872-blycbi4u	39	10	obtained	obtain	VBN
cord-300872-blycbi4u	39	11	from	from	IN
cord-300872-blycbi4u	39	12	different	different	JJ
cord-300872-blycbi4u	39	13	databases	database	NNS
cord-300872-blycbi4u	39	14	,	,	,
cord-300872-blycbi4u	39	15	such	such	JJ
cord-300872-blycbi4u	39	16	as	as	IN
cord-300872-blycbi4u	39	17	Medical	Medical	NNP
cord-300872-blycbi4u	39	18	Literature	Literature	NNP
cord-300872-blycbi4u	39	19	Retrieval	Retrieval	NNP
cord-300872-blycbi4u	39	20	Analysis	Analysis	NNP
cord-300872-blycbi4u	39	21	and	and	CC
cord-300872-blycbi4u	39	22	Retrieval	Retrieval	NNP
cord-300872-blycbi4u	39	23	System	System	NNP
cord-300872-blycbi4u	39	24	Online	Online	NNP
cord-300872-blycbi4u	39	25	(	(	-LRB-
cord-300872-blycbi4u	39	26	MEDLINE	MEDLINE	NNP
cord-300872-blycbi4u	39	27	)	)	-RRB-
cord-300872-blycbi4u	39	28	(	(	-LRB-
cord-300872-blycbi4u	39	29	PubMed	PubMed	NNP
cord-300872-blycbi4u	39	30	)	)	-RRB-
cord-300872-blycbi4u	39	31	,	,	,
cord-300872-blycbi4u	39	32	Google	Google	NNP
cord-300872-blycbi4u	39	33	Scholar	Scholar	NNP
cord-300872-blycbi4u	39	34	,	,	,
cord-300872-blycbi4u	39	35	Science	Science	NNP
cord-300872-blycbi4u	39	36	Direct	Direct	NNP
cord-300872-blycbi4u	39	37	,	,	,
cord-300872-blycbi4u	39	38	Scopus	Scopus	NNP
cord-300872-blycbi4u	39	39	,	,	,
cord-300872-blycbi4u	39	40	Cochrane	Cochrane	NNP
cord-300872-blycbi4u	39	41	,	,	,
cord-300872-blycbi4u	39	42	SID	SID	NNP
cord-300872-blycbi4u	39	43	,	,	,
cord-300872-blycbi4u	39	44	and	and	CC
cord-300872-blycbi4u	39	45	SciFinder	SciFinder	NNP
cord-300872-blycbi4u	39	46	.	.	.
cord-300872-blycbi4u	40	1	Our	-PRON-	PRP$
cord-300872-blycbi4u	40	2	intention	intention	NN
cord-300872-blycbi4u	40	3	is	be	VBZ
cord-300872-blycbi4u	40	4	that	that	IN
cord-300872-blycbi4u	40	5	the	the	DT
cord-300872-blycbi4u	40	6	content	content	NN
cord-300872-blycbi4u	40	7	and	and	CC
cord-300872-blycbi4u	40	8	organization	organization	NN
cord-300872-blycbi4u	40	9	of	of	IN
cord-300872-blycbi4u	40	10	this	this	DT
cord-300872-blycbi4u	40	11	review	review	NN
cord-300872-blycbi4u	40	12	will	will	MD
cord-300872-blycbi4u	40	13	be	be	VB
cord-300872-blycbi4u	40	14	valuable	valuable	JJ
cord-300872-blycbi4u	40	15	to	to	IN
cord-300872-blycbi4u	40	16	the	the	DT
cord-300872-blycbi4u	40	17	field	field	NN
cord-300872-blycbi4u	40	18	and	and	CC
cord-300872-blycbi4u	40	19	will	will	MD
cord-300872-blycbi4u	40	20	greatly	greatly	RB
cord-300872-blycbi4u	40	21	help	help	VB
cord-300872-blycbi4u	40	22	researchers	researcher	NNS
cord-300872-blycbi4u	40	23	.	.	.
cord-300872-blycbi4u	41	1	Below	below	IN
cord-300872-blycbi4u	41	2	are	be	VBP
cord-300872-blycbi4u	41	3	details	detail	NNS
cord-300872-blycbi4u	41	4	about	about	IN
cord-300872-blycbi4u	41	5	the	the	DT
cord-300872-blycbi4u	41	6	recent	recent	JJ
cord-300872-blycbi4u	41	7	documented	document	VBN
cord-300872-blycbi4u	41	8	synthesis	synthesis	NN
cord-300872-blycbi4u	41	9	methods	method	NNS
cord-300872-blycbi4u	41	10	of	of	IN
cord-300872-blycbi4u	41	11	8-HQ	8-hq	CD
cord-300872-blycbi4u	41	12	and	and	CC
cord-300872-blycbi4u	41	13	its	-PRON-	PRP$
cord-300872-blycbi4u	41	14	derivatives	derivative	NNS
cord-300872-blycbi4u	41	15	,	,	,
cord-300872-blycbi4u	41	16	as	as	RB
cord-300872-blycbi4u	41	17	well	well	RB
cord-300872-blycbi4u	41	18	as	as	IN
cord-300872-blycbi4u	41	19	their	-PRON-	PRP$
cord-300872-blycbi4u	41	20	biological	biological	JJ
cord-300872-blycbi4u	41	21	activities	activity	NNS
cord-300872-blycbi4u	41	22	against	against	IN
cord-300872-blycbi4u	41	23	different	different	JJ
cord-300872-blycbi4u	41	24	diseases	disease	NNS
cord-300872-blycbi4u	41	25	and	and	CC
cord-300872-blycbi4u	41	26	disorders	disorder	NNS
cord-300872-blycbi4u	41	27	.	.	.
cord-300872-blycbi4u	42	1	Due	due	IN
cord-300872-blycbi4u	42	2	to	to	IN
cord-300872-blycbi4u	42	3	the	the	DT
cord-300872-blycbi4u	42	4	Coronavirus	Coronavirus	NNP
cord-300872-blycbi4u	42	5	2019	2019	CD
cord-300872-blycbi4u	42	6	(	(	-LRB-
cord-300872-blycbi4u	42	7	COVID-19	COVID-19	NNP
cord-300872-blycbi4u	42	8	)	)	-RRB-
cord-300872-blycbi4u	42	9	pandemic	pandemic	NN
cord-300872-blycbi4u	42	10	and	and	CC
cord-300872-blycbi4u	42	11	its	-PRON-	PRP$
cord-300872-blycbi4u	42	12	devastating	devastating	JJ
cord-300872-blycbi4u	42	13	economic	economic	JJ
cord-300872-blycbi4u	42	14	,	,	,
cord-300872-blycbi4u	42	15	social	social	JJ
cord-300872-blycbi4u	42	16	,	,	,
cord-300872-blycbi4u	42	17	and	and	CC
cord-300872-blycbi4u	42	18	health	health	NN
cord-300872-blycbi4u	42	19	effects	effect	NNS
cord-300872-blycbi4u	42	20	,	,	,
cord-300872-blycbi4u	42	21	we	-PRON-	PRP
cord-300872-blycbi4u	42	22	decided	decide	VBD
cord-300872-blycbi4u	42	23	to	to	TO
cord-300872-blycbi4u	42	24	start	start	VB
cord-300872-blycbi4u	42	25	this	this	DT
cord-300872-blycbi4u	42	26	study	study	NN
cord-300872-blycbi4u	42	27	with	with	IN
cord-300872-blycbi4u	42	28	the	the	DT
cord-300872-blycbi4u	42	29	antiviral	antiviral	JJ
cord-300872-blycbi4u	42	30	activities	activity	NNS
cord-300872-blycbi4u	42	31	of	of	IN
cord-300872-blycbi4u	42	32	some	some	DT
cord-300872-blycbi4u	42	33	recent	recent	JJ
cord-300872-blycbi4u	42	34	8-HQ	8-hq	CD
cord-300872-blycbi4u	42	35	derivatives	derivative	NNS
cord-300872-blycbi4u	42	36	.	.	.
cord-300872-blycbi4u	43	1	A	a	DT
cord-300872-blycbi4u	43	2	few	few	JJ
cord-300872-blycbi4u	43	3	publications	publication	NNS
cord-300872-blycbi4u	43	4	have	have	VBP
cord-300872-blycbi4u	43	5	dealt	deal	VBN
cord-300872-blycbi4u	43	6	with	with	IN
cord-300872-blycbi4u	43	7	the	the	DT
cord-300872-blycbi4u	43	8	antiviral	antiviral	JJ
cord-300872-blycbi4u	43	9	activities	activity	NNS
cord-300872-blycbi4u	43	10	of	of	IN
cord-300872-blycbi4u	43	11	8-HQ	8-hq	CD
cord-300872-blycbi4u	43	12	and	and	CC
cord-300872-blycbi4u	43	13	its	-PRON-	PRP$
cord-300872-blycbi4u	43	14	derivatives	derivative	NNS
cord-300872-blycbi4u	43	15	.	.	.
cord-300872-blycbi4u	44	1	De	De	NNP
cord-300872-blycbi4u	44	2	la	la	NNP
cord-300872-blycbi4u	44	3	Guardia	Guardia	NNP
cord-300872-blycbi4u	44	4	et	et	NNP
cord-300872-blycbi4u	44	5	al	al	NNP
cord-300872-blycbi4u	44	6	.	.	.
cord-300872-blycbi4u	45	1	described	describe	VBD
cord-300872-blycbi4u	45	2	the	the	DT
cord-300872-blycbi4u	45	3	synthesis	synthesis	NN
cord-300872-blycbi4u	45	4	of	of	IN
cord-300872-blycbi4u	45	5	novel	novel	JJ
cord-300872-blycbi4u	45	6	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	45	7	derivatives	derivative	NNS
cord-300872-blycbi4u	45	8	(	(	-LRB-
cord-300872-blycbi4u	45	9	Scheme	scheme	NN
cord-300872-blycbi4u	45	10	1	1	CD
cord-300872-blycbi4u	45	11	)	)	-RRB-
cord-300872-blycbi4u	45	12	and	and	CC
cord-300872-blycbi4u	45	13	investigated	investigate	VBD
cord-300872-blycbi4u	45	14	their	-PRON-	PRP$
cord-300872-blycbi4u	45	15	activity	activity	NN
cord-300872-blycbi4u	45	16	against	against	IN
cord-300872-blycbi4u	45	17	dengue	dengue	NN
cord-300872-blycbi4u	45	18	virus	virus	NN
cord-300872-blycbi4u	45	19	[	[	-LRB-
cord-300872-blycbi4u	45	20	7	7	CD
cord-300872-blycbi4u	45	21	]	]	-RRB-
cord-300872-blycbi4u	45	22	.	.	.
cord-300872-blycbi4u	46	1	These	these	DT
cord-300872-blycbi4u	46	2	researchers	researcher	NNS
cord-300872-blycbi4u	46	3	prepared	prepare	VBD
cord-300872-blycbi4u	46	4	a	a	DT
cord-300872-blycbi4u	46	5	number	number	NN
cord-300872-blycbi4u	46	6	of	of	IN
cord-300872-blycbi4u	46	7	compounds	compound	NNS
cord-300872-blycbi4u	46	8	from	from	IN
cord-300872-blycbi4u	46	9	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	46	10	N	n	CD
cord-300872-blycbi4u	46	11	-	-	HYPH
cord-300872-blycbi4u	46	12	oxide	oxide	NN
cord-300872-blycbi4u	46	13	2	2	CD
cord-300872-blycbi4u	46	14	,	,	,
cord-300872-blycbi4u	46	15	which	which	WDT
cord-300872-blycbi4u	46	16	upon	upon	IN
cord-300872-blycbi4u	46	17	treatment	treatment	NN
cord-300872-blycbi4u	46	18	with	with	IN
cord-300872-blycbi4u	46	19	copper	copper	NN
cord-300872-blycbi4u	46	20	-	-	HYPH
cord-300872-blycbi4u	46	21	catalyzed	catalyze	VBN
cord-300872-blycbi4u	46	22	Grignard	Grignard	NNP
cord-300872-blycbi4u	46	23	reagents	reagent	NNS
cord-300872-blycbi4u	46	24	(	(	-LRB-
cord-300872-blycbi4u	46	25	RMgX	rmgx	UH
cord-300872-blycbi4u	46	26	;	;	:
cord-300872-blycbi4u	46	27	R	r	NN
cord-300872-blycbi4u	46	28	=	=	SYM
cord-300872-blycbi4u	46	29	i	i	NN
cord-300872-blycbi4u	46	30	-	-	HYPH
cord-300872-blycbi4u	46	31	Pr	Pr	NNP
cord-300872-blycbi4u	46	32	and	and	CC
cord-300872-blycbi4u	46	33	i	i	PRP
cord-300872-blycbi4u	46	34	-	-	HYPH
cord-300872-blycbi4u	46	35	Bu	Bu	NNP
cord-300872-blycbi4u	46	36	)	)	-RRB-
cord-300872-blycbi4u	46	37	gave	give	VBD
cord-300872-blycbi4u	46	38	2-alkyl-8-hydroxyquinoline	2-alkyl-8-hydroxyquinoline	CD
cord-300872-blycbi4u	46	39	3	3	CD
cord-300872-blycbi4u	46	40	.	.	.
cord-300872-blycbi4u	47	1	Subsequent	subsequent	JJ
cord-300872-blycbi4u	47	2	chlorination	chlorination	NN
cord-300872-blycbi4u	47	3	using	use	VBG
cord-300872-blycbi4u	47	4	N	n	NN
cord-300872-blycbi4u	47	5	-	-	HYPH
cord-300872-blycbi4u	47	6	chlorosuccinimide	chlorosuccinimide	NNP
cord-300872-blycbi4u	47	7	(	(	-LRB-
cord-300872-blycbi4u	47	8	NCS	NCS	NNP
cord-300872-blycbi4u	47	9	)	)	-RRB-
cord-300872-blycbi4u	47	10	under	under	IN
cord-300872-blycbi4u	47	11	acidic	acidic	JJ
cord-300872-blycbi4u	47	12	conditions	condition	NNS
cord-300872-blycbi4u	47	13	afforded	afford	VBD
cord-300872-blycbi4u	47	14	the	the	DT
cord-300872-blycbi4u	47	15	corresponding	correspond	VBG
cord-300872-blycbi4u	47	16	2-alkyl-5,7-dichloro-8-hydroxyquinoline	2-alkyl-5,7-dichloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	47	17	4	4	CD
cord-300872-blycbi4u	47	18	in	in	IN
cord-300872-blycbi4u	47	19	a	a	DT
cord-300872-blycbi4u	47	20	good	good	JJ
cord-300872-blycbi4u	47	21	yield	yield	NN
cord-300872-blycbi4u	47	22	.	.	.
cord-300872-blycbi4u	48	1	Scheme	scheme	NN
cord-300872-blycbi4u	48	2	1	1	CD
cord-300872-blycbi4u	48	3	.	.	.
cord-300872-blycbi4u	49	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	49	2	of	of	IN
cord-300872-blycbi4u	49	3	2-isopropy	2-isopropy	CD
cord-300872-blycbi4u	49	4	,	,	,
cord-300872-blycbi4u	50	1	2-isobutyl-5,7-dichloro-8-hydroxyquinoline	2-isobutyl-5,7-dichloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	50	2	4	4	CD
cord-300872-blycbi4u	50	3	.	.	.
cord-300872-blycbi4u	51	1	8-Hydroxyquinoline	8-Hydroxyquinoline	NNP
cord-300872-blycbi4u	51	2	has	have	VBZ
cord-300872-blycbi4u	51	3	attracted	attract	VBN
cord-300872-blycbi4u	51	4	the	the	DT
cord-300872-blycbi4u	51	5	attention	attention	NN
cord-300872-blycbi4u	51	6	of	of	IN
cord-300872-blycbi4u	51	7	chemists	chemist	NNS
cord-300872-blycbi4u	51	8	,	,	,
cord-300872-blycbi4u	51	9	medicinal	medicinal	JJ
cord-300872-blycbi4u	51	10	chemists	chemist	NNS
cord-300872-blycbi4u	51	11	,	,	,
cord-300872-blycbi4u	51	12	and	and	CC
cord-300872-blycbi4u	51	13	people	people	NNS
cord-300872-blycbi4u	51	14	in	in	IN
cord-300872-blycbi4u	51	15	health	health	NN
cord-300872-blycbi4u	51	16	sciences	science	NNS
cord-300872-blycbi4u	51	17	due	due	IN
cord-300872-blycbi4u	51	18	to	to	IN
cord-300872-blycbi4u	51	19	its	-PRON-	PRP$
cord-300872-blycbi4u	51	20	unique	unique	JJ
cord-300872-blycbi4u	51	21	physical	physical	JJ
cord-300872-blycbi4u	51	22	and	and	CC
cord-300872-blycbi4u	51	23	chemical	chemical	JJ
cord-300872-blycbi4u	51	24	properties	property	NNS
cord-300872-blycbi4u	51	25	.	.	.
cord-300872-blycbi4u	52	1	The	the	DT
cord-300872-blycbi4u	52	2	interest	interest	NN
cord-300872-blycbi4u	52	3	in	in	IN
cord-300872-blycbi4u	52	4	this	this	DT
cord-300872-blycbi4u	52	5	compound	compound	NN
cord-300872-blycbi4u	52	6	and	and	CC
cord-300872-blycbi4u	52	7	its	-PRON-	PRP$
cord-300872-blycbi4u	52	8	derivatives	derivative	NNS
cord-300872-blycbi4u	52	9	has	have	VBZ
cord-300872-blycbi4u	52	10	increased	increase	VBN
cord-300872-blycbi4u	52	11	considerably	considerably	RB
cord-300872-blycbi4u	52	12	in	in	IN
cord-300872-blycbi4u	52	13	the	the	DT
cord-300872-blycbi4u	52	14	last	last	JJ
cord-300872-blycbi4u	52	15	two	two	CD
cord-300872-blycbi4u	52	16	decades	decade	NNS
cord-300872-blycbi4u	52	17	[	[	-LRB-
cord-300872-blycbi4u	52	18	3	3	CD
cord-300872-blycbi4u	52	19	]	]	-RRB-
cord-300872-blycbi4u	52	20	.	.	.
cord-300872-blycbi4u	53	1	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	53	2	and	and	CC
cord-300872-blycbi4u	53	3	many	many	JJ
cord-300872-blycbi4u	53	4	of	of	IN
cord-300872-blycbi4u	53	5	its	-PRON-	PRP$
cord-300872-blycbi4u	53	6	derivatives	derivative	NNS
cord-300872-blycbi4u	53	7	have	have	VBP
cord-300872-blycbi4u	53	8	a	a	DT
cord-300872-blycbi4u	53	9	wide	wide	JJ
cord-300872-blycbi4u	53	10	range	range	NN
cord-300872-blycbi4u	53	11	of	of	IN
cord-300872-blycbi4u	53	12	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	53	13	applications	application	NNS
cord-300872-blycbi4u	53	14	,	,	,
cord-300872-blycbi4u	53	15	e.g.	e.g.	RB
cord-300872-blycbi4u	53	16	,	,	,
cord-300872-blycbi4u	53	17	as	as	IN
cord-300872-blycbi4u	53	18	iron	iron	NN
cord-300872-blycbi4u	53	19	-	-	HYPH
cord-300872-blycbi4u	53	20	chelators	chelator	NNS
cord-300872-blycbi4u	53	21	for	for	IN
cord-300872-blycbi4u	53	22	neuroprotection	neuroprotection	NN
cord-300872-blycbi4u	53	23	,	,	,
cord-300872-blycbi4u	53	24	as	as	IN
cord-300872-blycbi4u	53	25	anticancer	anticancer	JJ
cord-300872-blycbi4u	53	26	agents	agent	NNS
cord-300872-blycbi4u	53	27	,	,	,
cord-300872-blycbi4u	53	28	as	as	IN
cord-300872-blycbi4u	53	29	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	53	30	of	of	IN
cord-300872-blycbi4u	53	31	2OG	2og	CD
cord-300872-blycbi4u	53	32	-	-	HYPH
cord-300872-blycbi4u	53	33	dependent	dependent	JJ
cord-300872-blycbi4u	53	34	enzymes	enzyme	NNS
cord-300872-blycbi4u	53	35	,	,	,
cord-300872-blycbi4u	53	36	as	as	IN
cord-300872-blycbi4u	53	37	chelators	chelator	NNS
cord-300872-blycbi4u	53	38	of	of	IN
cord-300872-blycbi4u	53	39	metalloproteins	metalloproteins	NNP
cord-300872-blycbi4u	53	40	,	,	,
cord-300872-blycbi4u	53	41	as	as	IN
cord-300872-blycbi4u	53	42	anti	anti	JJ
cord-300872-blycbi4u	53	43	-	-	JJ
cord-300872-blycbi4u	53	44	HIV	hiv	JJ
cord-300872-blycbi4u	53	45	agents	agent	NNS
cord-300872-blycbi4u	53	46	,	,	,
cord-300872-blycbi4u	53	47	as	as	IN
cord-300872-blycbi4u	53	48	antifungal	antifungal	JJ
cord-300872-blycbi4u	53	49	agents	agent	NNS
cord-300872-blycbi4u	53	50	,	,	,
cord-300872-blycbi4u	53	51	as	as	IN
cord-300872-blycbi4u	53	52	antileishmanial	antileishmanial	NNP
cord-300872-blycbi4u	53	53	agents	agent	NNS
cord-300872-blycbi4u	53	54	,	,	,
cord-300872-blycbi4u	53	55	as	as	IN
cord-300872-blycbi4u	53	56	antischistosomal	antischistosomal	NNP
cord-300872-blycbi4u	53	57	agents	agent	NNS
cord-300872-blycbi4u	53	58	,	,	,
cord-300872-blycbi4u	53	59	as	as	IN
cord-300872-blycbi4u	53	60	mycobacterium	mycobacterium	NNP
cord-300872-blycbi4u	53	61	tuberculosis	tuberculosis	NN
cord-300872-blycbi4u	53	62	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	53	63	,	,	,
cord-300872-blycbi4u	53	64	and	and	CC
cord-300872-blycbi4u	53	65	as	as	IN
cord-300872-blycbi4u	53	66	botulinum	botulinum	NN
cord-300872-blycbi4u	53	67	neurotoxin	neurotoxin	NN
cord-300872-blycbi4u	53	68	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	53	69	[	[	-LRB-
cord-300872-blycbi4u	53	70	4	4	CD
cord-300872-blycbi4u	53	71	]	]	-RRB-
cord-300872-blycbi4u	53	72	.	.	.
cord-300872-blycbi4u	54	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	54	2	,	,	,
cord-300872-blycbi4u	54	3	these	these	DT
cord-300872-blycbi4u	54	4	compounds	compound	NNS
cord-300872-blycbi4u	54	5	are	be	VBP
cord-300872-blycbi4u	54	6	used	use	VBN
cord-300872-blycbi4u	54	7	as	as	IN
cord-300872-blycbi4u	54	8	electron	electron	NN
cord-300872-blycbi4u	54	9	carriers	carrier	NNS
cord-300872-blycbi4u	54	10	in	in	IN
cord-300872-blycbi4u	54	11	organic	organic	JJ
cord-300872-blycbi4u	54	12	light	light	NN
cord-300872-blycbi4u	54	13	-	-	HYPH
cord-300872-blycbi4u	54	14	emitting	emit	VBG
cord-300872-blycbi4u	54	15	diodes	diode	NNS
cord-300872-blycbi4u	54	16	(	(	-LRB-
cord-300872-blycbi4u	54	17	OLEDs	OLEDs	NNP
cord-300872-blycbi4u	54	18	)	)	-RRB-
cord-300872-blycbi4u	54	19	and	and	CC
cord-300872-blycbi4u	54	20	as	as	IN
cord-300872-blycbi4u	54	21	fluorescent	fluorescent	JJ
cord-300872-blycbi4u	54	22	chemosensors	chemosensor	NNS
cord-300872-blycbi4u	54	23	for	for	IN
cord-300872-blycbi4u	54	24	metal	metal	NN
cord-300872-blycbi4u	54	25	ions	ion	NNS
cord-300872-blycbi4u	54	26	[	[	-LRB-
cord-300872-blycbi4u	54	27	5	5	CD
cord-300872-blycbi4u	54	28	,	,	,
cord-300872-blycbi4u	54	29	6	6	CD
cord-300872-blycbi4u	54	30	]	]	-RRB-
cord-300872-blycbi4u	54	31	.	.	.
cord-300872-blycbi4u	55	1	On	on	IN
cord-300872-blycbi4u	55	2	the	the	DT
cord-300872-blycbi4u	55	3	basis	basis	NN
cord-300872-blycbi4u	55	4	of	of	IN
cord-300872-blycbi4u	55	5	the	the	DT
cord-300872-blycbi4u	55	6	preceding	precede	VBG
cord-300872-blycbi4u	55	7	discussion	discussion	NN
cord-300872-blycbi4u	55	8	,	,	,
cord-300872-blycbi4u	55	9	and	and	CC
cord-300872-blycbi4u	55	10	owing	owe	VBG
cord-300872-blycbi4u	55	11	to	to	IN
cord-300872-blycbi4u	55	12	the	the	DT
cord-300872-blycbi4u	55	13	importance	importance	NN
cord-300872-blycbi4u	55	14	of	of	IN
cord-300872-blycbi4u	55	15	8-HQ	8-hq	CD
cord-300872-blycbi4u	55	16	from	from	IN
cord-300872-blycbi4u	55	17	a	a	DT
cord-300872-blycbi4u	55	18	chemistry	chemistry	NN
cord-300872-blycbi4u	55	19	point	point	NN
cord-300872-blycbi4u	55	20	of	of	IN
cord-300872-blycbi4u	55	21	view	view	NN
cord-300872-blycbi4u	55	22	and	and	CC
cord-300872-blycbi4u	55	23	to	to	IN
cord-300872-blycbi4u	55	24	the	the	DT
cord-300872-blycbi4u	55	25	wide	wide	JJ
cord-300872-blycbi4u	55	26	range	range	NN
cord-300872-blycbi4u	55	27	of	of	IN
cord-300872-blycbi4u	55	28	biological	biological	JJ
cord-300872-blycbi4u	55	29	activities	activity	NNS
cord-300872-blycbi4u	55	30	and	and	CC
cord-300872-blycbi4u	55	31	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	55	32	applications	application	NNS
cord-300872-blycbi4u	55	33	of	of	IN
cord-300872-blycbi4u	55	34	8-HQ	8-hq	CD
cord-300872-blycbi4u	55	35	and	and	CC
cord-300872-blycbi4u	55	36	derivatives	derivative	NNS
cord-300872-blycbi4u	55	37	,	,	,
cord-300872-blycbi4u	55	38	this	this	DT
cord-300872-blycbi4u	55	39	review	review	NN
cord-300872-blycbi4u	55	40	focuses	focus	VBZ
cord-300872-blycbi4u	55	41	on	on	IN
cord-300872-blycbi4u	55	42	current	current	JJ
cord-300872-blycbi4u	55	43	knowledge	knowledge	NN
cord-300872-blycbi4u	55	44	of	of	IN
cord-300872-blycbi4u	55	45	the	the	DT
cord-300872-blycbi4u	55	46	synthetic	synthetic	JJ
cord-300872-blycbi4u	55	47	methods	method	NNS
cord-300872-blycbi4u	55	48	of	of	IN
cord-300872-blycbi4u	55	49	novel	novel	JJ
cord-300872-blycbi4u	55	50	derivatives	derivative	NNS
cord-300872-blycbi4u	55	51	,	,	,
cord-300872-blycbi4u	55	52	along	along	IN
cord-300872-blycbi4u	55	53	with	with	IN
cord-300872-blycbi4u	55	54	the	the	DT
cord-300872-blycbi4u	55	55	derivatives	derivative	NNS
cord-300872-blycbi4u	55	56	'	'	POS
cord-300872-blycbi4u	55	57	biological	biological	JJ
cord-300872-blycbi4u	55	58	activities	activity	NNS
cord-300872-blycbi4u	55	59	and	and	CC
cord-300872-blycbi4u	55	60	medicinal	medicinal	JJ
cord-300872-blycbi4u	55	61	applications	application	NNS
cord-300872-blycbi4u	55	62	.	.	.
cord-300872-blycbi4u	56	1	In	in	IN
cord-300872-blycbi4u	56	2	addition	addition	NN
cord-300872-blycbi4u	56	3	,	,	,
cord-300872-blycbi4u	56	4	this	this	DT
cord-300872-blycbi4u	56	5	review	review	NN
cord-300872-blycbi4u	56	6	summarizes	summarize	VBZ
cord-300872-blycbi4u	56	7	the	the	DT
cord-300872-blycbi4u	56	8	most	most	RBS
cord-300872-blycbi4u	56	9	recent	recent	JJ
cord-300872-blycbi4u	56	10	literature	literature	NN
cord-300872-blycbi4u	56	11	pertaining	pertain	VBG
cord-300872-blycbi4u	56	12	to	to	IN
cord-300872-blycbi4u	56	13	the	the	DT
cord-300872-blycbi4u	56	14	synthesis	synthesis	NN
cord-300872-blycbi4u	56	15	and	and	CC
cord-300872-blycbi4u	56	16	bioactivity	bioactivity	NN
cord-300872-blycbi4u	56	17	of	of	IN
cord-300872-blycbi4u	56	18	8-HQ	8-hq	CD
cord-300872-blycbi4u	56	19	and	and	CC
cord-300872-blycbi4u	56	20	its	-PRON-	PRP$
cord-300872-blycbi4u	56	21	derivatives	derivative	NNS
cord-300872-blycbi4u	56	22	,	,	,
cord-300872-blycbi4u	56	23	covering	cover	VBG
cord-300872-blycbi4u	56	24	the	the	DT
cord-300872-blycbi4u	56	25	period	period	NN
cord-300872-blycbi4u	56	26	ranging	range	VBG
cord-300872-blycbi4u	56	27	from	from	IN
cord-300872-blycbi4u	56	28	2017	2017	CD
cord-300872-blycbi4u	56	29	to	to	IN
cord-300872-blycbi4u	56	30	the	the	DT
cord-300872-blycbi4u	56	31	present	present	NN
cord-300872-blycbi4u	56	32	.	.	.
cord-300872-blycbi4u	57	1	In	in	IN
cord-300872-blycbi4u	57	2	addition	addition	NN
cord-300872-blycbi4u	57	3	,	,	,
cord-300872-blycbi4u	57	4	structure	structure	NN
cord-300872-blycbi4u	57	5	-	-	HYPH
cord-300872-blycbi4u	57	6	activity	activity	NN
cord-300872-blycbi4u	57	7	relationships	relationship	NNS
cord-300872-blycbi4u	57	8	(	(	-LRB-
cord-300872-blycbi4u	57	9	SARs	SARs	NNP
cord-300872-blycbi4u	57	10	)	)	-RRB-
cord-300872-blycbi4u	57	11	of	of	IN
cord-300872-blycbi4u	57	12	these	these	DT
cord-300872-blycbi4u	57	13	derivatives	derivative	NNS
cord-300872-blycbi4u	57	14	are	be	VBP
cord-300872-blycbi4u	57	15	discussed	discuss	VBN
cord-300872-blycbi4u	57	16	to	to	TO
cord-300872-blycbi4u	57	17	provide	provide	VB
cord-300872-blycbi4u	57	18	directions	direction	NNS
cord-300872-blycbi4u	57	19	for	for	IN
cord-300872-blycbi4u	57	20	further	further	JJ
cord-300872-blycbi4u	57	21	development	development	NN
cord-300872-blycbi4u	57	22	of	of	IN
cord-300872-blycbi4u	57	23	novel	novel	JJ
cord-300872-blycbi4u	57	24	8-HQ	8-hq	CD
cord-300872-blycbi4u	57	25	-	-	HYPH
cord-300872-blycbi4u	57	26	based	base	VBN
cord-300872-blycbi4u	57	27	bioactive	bioactive	JJ
cord-300872-blycbi4u	57	28	agents	agent	NNS
cord-300872-blycbi4u	57	29	.	.	.
cord-300872-blycbi4u	58	1	For	for	IN
cord-300872-blycbi4u	58	2	this	this	DT
cord-300872-blycbi4u	58	3	purpose	purpose	NN
cord-300872-blycbi4u	58	4	,	,	,
cord-300872-blycbi4u	58	5	recent	recent	JJ
cord-300872-blycbi4u	58	6	relevant	relevant	JJ
cord-300872-blycbi4u	58	7	references	reference	NNS
cord-300872-blycbi4u	58	8	have	have	VBP
cord-300872-blycbi4u	58	9	been	be	VBN
cord-300872-blycbi4u	58	10	obtained	obtain	VBN
cord-300872-blycbi4u	58	11	from	from	IN
cord-300872-blycbi4u	58	12	different	different	JJ
cord-300872-blycbi4u	58	13	databases	database	NNS
cord-300872-blycbi4u	58	14	,	,	,
cord-300872-blycbi4u	58	15	such	such	JJ
cord-300872-blycbi4u	58	16	as	as	IN
cord-300872-blycbi4u	58	17	Medical	Medical	NNP
cord-300872-blycbi4u	58	18	Literature	Literature	NNP
cord-300872-blycbi4u	58	19	Retrieval	Retrieval	NNP
cord-300872-blycbi4u	58	20	Analysis	Analysis	NNP
cord-300872-blycbi4u	58	21	and	and	CC
cord-300872-blycbi4u	58	22	Retrieval	Retrieval	NNP
cord-300872-blycbi4u	58	23	System	System	NNP
cord-300872-blycbi4u	58	24	Online	Online	NNP
cord-300872-blycbi4u	58	25	(	(	-LRB-
cord-300872-blycbi4u	58	26	MEDLINE	MEDLINE	NNP
cord-300872-blycbi4u	58	27	)	)	-RRB-
cord-300872-blycbi4u	58	28	(	(	-LRB-
cord-300872-blycbi4u	58	29	PubMed	PubMed	NNP
cord-300872-blycbi4u	58	30	)	)	-RRB-
cord-300872-blycbi4u	58	31	,	,	,
cord-300872-blycbi4u	58	32	Google	Google	NNP
cord-300872-blycbi4u	58	33	Scholar	Scholar	NNP
cord-300872-blycbi4u	58	34	,	,	,
cord-300872-blycbi4u	58	35	Science	Science	NNP
cord-300872-blycbi4u	58	36	Direct	Direct	NNP
cord-300872-blycbi4u	58	37	,	,	,
cord-300872-blycbi4u	58	38	Scopus	Scopus	NNP
cord-300872-blycbi4u	58	39	,	,	,
cord-300872-blycbi4u	58	40	Cochrane	Cochrane	NNP
cord-300872-blycbi4u	58	41	,	,	,
cord-300872-blycbi4u	58	42	SID	SID	NNP
cord-300872-blycbi4u	58	43	,	,	,
cord-300872-blycbi4u	58	44	and	and	CC
cord-300872-blycbi4u	58	45	SciFinder	SciFinder	NNP
cord-300872-blycbi4u	58	46	.	.	.
cord-300872-blycbi4u	59	1	Our	-PRON-	PRP$
cord-300872-blycbi4u	59	2	intention	intention	NN
cord-300872-blycbi4u	59	3	is	be	VBZ
cord-300872-blycbi4u	59	4	that	that	IN
cord-300872-blycbi4u	59	5	the	the	DT
cord-300872-blycbi4u	59	6	content	content	NN
cord-300872-blycbi4u	59	7	and	and	CC
cord-300872-blycbi4u	59	8	organization	organization	NN
cord-300872-blycbi4u	59	9	of	of	IN
cord-300872-blycbi4u	59	10	this	this	DT
cord-300872-blycbi4u	59	11	review	review	NN
cord-300872-blycbi4u	59	12	will	will	MD
cord-300872-blycbi4u	59	13	be	be	VB
cord-300872-blycbi4u	59	14	valuable	valuable	JJ
cord-300872-blycbi4u	59	15	to	to	IN
cord-300872-blycbi4u	59	16	the	the	DT
cord-300872-blycbi4u	59	17	field	field	NN
cord-300872-blycbi4u	59	18	and	and	CC
cord-300872-blycbi4u	59	19	will	will	MD
cord-300872-blycbi4u	59	20	greatly	greatly	RB
cord-300872-blycbi4u	59	21	help	help	VB
cord-300872-blycbi4u	59	22	researchers	researcher	NNS
cord-300872-blycbi4u	59	23	.	.	.
cord-300872-blycbi4u	60	1	Below	below	IN
cord-300872-blycbi4u	60	2	are	be	VBP
cord-300872-blycbi4u	60	3	details	detail	NNS
cord-300872-blycbi4u	60	4	about	about	IN
cord-300872-blycbi4u	60	5	the	the	DT
cord-300872-blycbi4u	60	6	recent	recent	JJ
cord-300872-blycbi4u	60	7	documented	document	VBN
cord-300872-blycbi4u	60	8	synthesis	synthesis	NN
cord-300872-blycbi4u	60	9	methods	method	NNS
cord-300872-blycbi4u	60	10	of	of	IN
cord-300872-blycbi4u	60	11	8-HQ	8-hq	CD
cord-300872-blycbi4u	60	12	and	and	CC
cord-300872-blycbi4u	60	13	its	-PRON-	PRP$
cord-300872-blycbi4u	60	14	derivatives	derivative	NNS
cord-300872-blycbi4u	60	15	,	,	,
cord-300872-blycbi4u	60	16	as	as	RB
cord-300872-blycbi4u	60	17	well	well	RB
cord-300872-blycbi4u	60	18	as	as	IN
cord-300872-blycbi4u	60	19	their	-PRON-	PRP$
cord-300872-blycbi4u	60	20	biological	biological	JJ
cord-300872-blycbi4u	60	21	activities	activity	NNS
cord-300872-blycbi4u	60	22	against	against	IN
cord-300872-blycbi4u	60	23	different	different	JJ
cord-300872-blycbi4u	60	24	diseases	disease	NNS
cord-300872-blycbi4u	60	25	and	and	CC
cord-300872-blycbi4u	60	26	disorders	disorder	NNS
cord-300872-blycbi4u	60	27	.	.	.
cord-300872-blycbi4u	61	1	In	in	IN
cord-300872-blycbi4u	61	2	a	a	DT
cord-300872-blycbi4u	61	3	similar	similar	JJ
cord-300872-blycbi4u	61	4	fashion	fashion	NN
cord-300872-blycbi4u	61	5	,	,	,
cord-300872-blycbi4u	61	6	Kos	Kos	NNP
cord-300872-blycbi4u	61	7	and	and	CC
cord-300872-blycbi4u	61	8	coworkers	coworker	NNS
cord-300872-blycbi4u	61	9	reported	report	VBD
cord-300872-blycbi4u	61	10	the	the	DT
cord-300872-blycbi4u	61	11	microwave	microwave	NN
cord-300872-blycbi4u	61	12	-	-	HYPH
cord-300872-blycbi4u	61	13	assisted	assist	VBN
cord-300872-blycbi4u	61	14	synthesis	synthesis	NN
cord-300872-blycbi4u	61	15	of	of	IN
cord-300872-blycbi4u	61	16	thirty	thirty	CD
cord-300872-blycbi4u	61	17	-	-	HYPH
cord-300872-blycbi4u	61	18	two	two	CD
cord-300872-blycbi4u	61	19	mono-	mono-	NN
cord-300872-blycbi4u	61	20	,	,	,
cord-300872-blycbi4u	61	21	di-	di-	XX
cord-300872-blycbi4u	61	22	,	,	,
cord-300872-blycbi4u	61	23	and	and	CC
cord-300872-blycbi4u	61	24	tri	tri	JJ
cord-300872-blycbi4u	61	25	-	-	JJ
cord-300872-blycbi4u	61	26	substituted	substitute	VBN
cord-300872-blycbi4u	61	27	8-hydroxyquinoline-2-carboxanilides	8-hydroxyquinoline-2-carboxanilides	CD
cord-300872-blycbi4u	61	28	,	,	,
cord-300872-blycbi4u	61	29	as	as	IN
cord-300872-blycbi4u	61	30	shown	show	VBN
cord-300872-blycbi4u	61	31	in	in	IN
cord-300872-blycbi4u	61	32	Scheme	scheme	NN
cord-300872-blycbi4u	61	33	2	2	CD
cord-300872-blycbi4u	61	34	[	[	-LRB-
cord-300872-blycbi4u	61	35	8	8	CD
cord-300872-blycbi4u	61	36	]	]	-RRB-
cord-300872-blycbi4u	61	37	.	.	.
cord-300872-blycbi4u	62	1	Condensation	condensation	NN
cord-300872-blycbi4u	62	2	of	of	IN
cord-300872-blycbi4u	62	3	activated	activate	VBN
cord-300872-blycbi4u	62	4	8-hydroxyquinoline-2-carboxylic	8-hydroxyquinoline-2-carboxylic	CD
cord-300872-blycbi4u	62	5	acid	acid	NN
cord-300872-blycbi4u	62	6	(	(	-LRB-
cord-300872-blycbi4u	62	7	5	5	CD
cord-300872-blycbi4u	62	8	)	)	-RRB-
cord-300872-blycbi4u	62	9	with	with	IN
cord-300872-blycbi4u	62	10	substituted	substitute	VBN
cord-300872-blycbi4u	62	11	aniline	aniline	NN
cord-300872-blycbi4u	62	12	6	6	CD
cord-300872-blycbi4u	62	13	in	in	IN
cord-300872-blycbi4u	62	14	the	the	DT
cord-300872-blycbi4u	62	15	presence	presence	NN
cord-300872-blycbi4u	62	16	of	of	IN
cord-300872-blycbi4u	62	17	by	by	IN
cord-300872-blycbi4u	62	18	phosphorus	phosphorus	NN
cord-300872-blycbi4u	62	19	trichloride	trichloride	NN
cord-300872-blycbi4u	62	20	yielded	yield	VBD
cord-300872-blycbi4u	62	21	the	the	DT
cord-300872-blycbi4u	62	22	desired	desire	VBN
cord-300872-blycbi4u	62	23	target	target	NN
cord-300872-blycbi4u	62	24	compound	compound	NN
cord-300872-blycbi4u	62	25	7	7	CD
cord-300872-blycbi4u	62	26	in	in	IN
cord-300872-blycbi4u	62	27	good	good	JJ
cord-300872-blycbi4u	62	28	amounts	amount	NNS
cord-300872-blycbi4u	62	29	(	(	-LRB-
cord-300872-blycbi4u	62	30	61	61	CD
cord-300872-blycbi4u	62	31	-	-	SYM
cord-300872-blycbi4u	62	32	79	79	CD
cord-300872-blycbi4u	62	33	%	%	NN
cord-300872-blycbi4u	62	34	)	)	-RRB-
cord-300872-blycbi4u	62	35	.	.	.
cord-300872-blycbi4u	63	1	Molecules	molecule	NNS
cord-300872-blycbi4u	63	2	2020	2020	CD
cord-300872-blycbi4u	63	3	,	,	,
cord-300872-blycbi4u	63	4	25	25	CD
cord-300872-blycbi4u	63	5	,	,	,
cord-300872-blycbi4u	63	6	x	x	NN
cord-300872-blycbi4u	63	7	FOR	for	IN
cord-300872-blycbi4u	63	8	PEER	peer	NN
cord-300872-blycbi4u	63	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	63	10	3	3	CD
cord-300872-blycbi4u	63	11	of	of	IN
cord-300872-blycbi4u	63	12	26	26	CD
cord-300872-blycbi4u	64	1	The	the	DT
cord-300872-blycbi4u	64	2	antiviral	antiviral	JJ
cord-300872-blycbi4u	64	3	activities	activity	NNS
cord-300872-blycbi4u	64	4	of	of	IN
cord-300872-blycbi4u	64	5	the	the	DT
cord-300872-blycbi4u	64	6	two	two	CD
cord-300872-blycbi4u	64	7	novel	novel	JJ
cord-300872-blycbi4u	64	8	quinoline	quinoline	NN
cord-300872-blycbi4u	64	9	derivatives	derivative	NNS
cord-300872-blycbi4u	64	10	(	(	-LRB-
cord-300872-blycbi4u	64	11	R	r	NN
cord-300872-blycbi4u	64	12	=	=	SYM
cord-300872-blycbi4u	64	13	i	i	NN
cord-300872-blycbi4u	64	14	-	-	HYPH
cord-300872-blycbi4u	64	15	Pr	Pr	NNP
cord-300872-blycbi4u	64	16	and	and	CC
cord-300872-blycbi4u	64	17	i	i	PRP
cord-300872-blycbi4u	64	18	-	-	HYPH
cord-300872-blycbi4u	64	19	Bu	Bu	NNP
cord-300872-blycbi4u	64	20	)	)	-RRB-
cord-300872-blycbi4u	64	21	4	4	CD
cord-300872-blycbi4u	64	22	were	be	VBD
cord-300872-blycbi4u	64	23	evaluated	evaluate	VBN
cord-300872-blycbi4u	64	24	in	in	IN
cord-300872-blycbi4u	64	25	vitro	vitro	FW
cord-300872-blycbi4u	64	26	against	against	IN
cord-300872-blycbi4u	64	27	the	the	DT
cord-300872-blycbi4u	64	28	dengue	dengue	NN
cord-300872-blycbi4u	64	29	virus	virus	NN
cord-300872-blycbi4u	64	30	serotype	serotype	NN
cord-300872-blycbi4u	64	31	2	2	CD
cord-300872-blycbi4u	64	32	(	(	-LRB-
cord-300872-blycbi4u	64	33	DENV2	denv2	NN
cord-300872-blycbi4u	64	34	)	)	-RRB-
cord-300872-blycbi4u	64	35	.	.	.
cord-300872-blycbi4u	65	1	Both	both	DT
cord-300872-blycbi4u	65	2	exhibited	exhibit	VBD
cord-300872-blycbi4u	65	3	significant	significant	JJ
cord-300872-blycbi4u	65	4	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	65	5	activities	activity	NNS
cord-300872-blycbi4u	65	6	against	against	IN
cord-300872-blycbi4u	65	7	this	this	DT
cord-300872-blycbi4u	65	8	virus	virus	NN
cord-300872-blycbi4u	65	9	.	.	.
cord-300872-blycbi4u	66	1	The	the	DT
cord-300872-blycbi4u	66	2	results	result	NNS
cord-300872-blycbi4u	66	3	indicated	indicate	VBD
cord-300872-blycbi4u	66	4	that	that	IN
cord-300872-blycbi4u	66	5	the	the	DT
cord-300872-blycbi4u	66	6	iso	iso	JJ
cord-300872-blycbi4u	66	7	-	-	HYPH
cord-300872-blycbi4u	66	8	Pr	pr	NN
cord-300872-blycbi4u	66	9	-	-	HYPH
cord-300872-blycbi4u	66	10	substituted	substitute	VBN
cord-300872-blycbi4u	66	11	derivative	derivative	NN
cord-300872-blycbi4u	66	12	exhibits	exhibit	VBZ
cord-300872-blycbi4u	66	13	a	a	DT
cord-300872-blycbi4u	66	14	half	half	RB
cord-300872-blycbi4u	66	15	-	-	HYPH
cord-300872-blycbi4u	66	16	maximal	maximal	JJ
cord-300872-blycbi4u	66	17	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	66	18	concentration	concentration	NN
cord-300872-blycbi4u	66	19	(	(	-LRB-
cord-300872-blycbi4u	66	20	IC50	IC50	NNP
cord-300872-blycbi4u	66	21	)	)	-RRB-
cord-300872-blycbi4u	66	22	of	of	IN
cord-300872-blycbi4u	66	23	3.03	3.03	CD
cord-300872-blycbi4u	66	24	µM	µm	CD
cord-300872-blycbi4u	66	25	and	and	CC
cord-300872-blycbi4u	66	26	a	a	DT
cord-300872-blycbi4u	66	27	half	half	RB
cord-300872-blycbi4u	66	28	-	-	HYPH
cord-300872-blycbi4u	66	29	maximal	maximal	JJ
cord-300872-blycbi4u	66	30	cytotoxic	cytotoxic	JJ
cord-300872-blycbi4u	66	31	concentration	concentration	NN
cord-300872-blycbi4u	66	32	(	(	-LRB-
cord-300872-blycbi4u	66	33	CC50	CC50	NNP
cord-300872-blycbi4u	66	34	)	)	-RRB-
cord-300872-blycbi4u	66	35	of	of	IN
cord-300872-blycbi4u	66	36	16.06	16.06	CD
cord-300872-blycbi4u	66	37	µM	µm	CD
cord-300872-blycbi4u	66	38	,	,	,
cord-300872-blycbi4u	66	39	for	for	IN
cord-300872-blycbi4u	66	40	an	an	DT
cord-300872-blycbi4u	66	41	estimated	estimate	VBN
cord-300872-blycbi4u	66	42	selectivity	selectivity	NN
cord-300872-blycbi4u	66	43	index	index	NN
cord-300872-blycbi4u	66	44	(	(	-LRB-
cord-300872-blycbi4u	66	45	SI	SI	NNP
cord-300872-blycbi4u	66	46	)	)	-RRB-
cord-300872-blycbi4u	66	47	of	of	IN
cord-300872-blycbi4u	66	48	5.30	5.30	CD
cord-300872-blycbi4u	66	49	.	.	.
cord-300872-blycbi4u	67	1	On	on	IN
cord-300872-blycbi4u	67	2	the	the	DT
cord-300872-blycbi4u	67	3	other	other	JJ
cord-300872-blycbi4u	67	4	hand	hand	NN
cord-300872-blycbi4u	67	5	,	,	,
cord-300872-blycbi4u	67	6	the	the	DT
cord-300872-blycbi4u	67	7	iso	iso	NNP
cord-300872-blycbi4u	67	8	-	-	HYPH
cord-300872-blycbi4u	67	9	Bu	Bu	NNP
cord-300872-blycbi4u	67	10	derivative	derivative	NN
cord-300872-blycbi4u	67	11	was	be	VBD
cord-300872-blycbi4u	67	12	also	also	RB
cord-300872-blycbi4u	67	13	active	active	JJ
cord-300872-blycbi4u	67	14	,	,	,
cord-300872-blycbi4u	67	15	showing	show	VBG
cord-300872-blycbi4u	67	16	a	a	DT
cord-300872-blycbi4u	67	17	higher	high	JJR
cord-300872-blycbi4u	67	18	SI	SI	NNP
cord-300872-blycbi4u	67	19	value	value	NN
cord-300872-blycbi4u	67	20	of	of	IN
cord-300872-blycbi4u	67	21	39.5	39.5	CD
cord-300872-blycbi4u	67	22	,	,	,
cord-300872-blycbi4u	67	23	with	with	IN
cord-300872-blycbi4u	67	24	an	an	DT
cord-300872-blycbi4u	67	25	IC50	IC50	NNP
cord-300872-blycbi4u	67	26	of	of	IN
cord-300872-blycbi4u	67	27	0.49	0.49	CD
cord-300872-blycbi4u	67	28	µM	µM	NNS
cord-300872-blycbi4u	67	29	and	and	CC
cord-300872-blycbi4u	67	30	CC50	CC50	NNP
cord-300872-blycbi4u	67	31	of	of	IN
cord-300872-blycbi4u	67	32	19.39	19.39	CD
cord-300872-blycbi4u	67	33	µM.	µm.	NN
cord-300872-blycbi4u	68	1	The	the	DT
cord-300872-blycbi4u	68	2	mechanism	mechanism	NN
cord-300872-blycbi4u	68	3	of	of	IN
cord-300872-blycbi4u	68	4	action	action	NN
cord-300872-blycbi4u	68	5	was	be	VBD
cord-300872-blycbi4u	68	6	also	also	RB
cord-300872-blycbi4u	68	7	investigated	investigate	VBN
cord-300872-blycbi4u	68	8	and	and	CC
cord-300872-blycbi4u	68	9	the	the	DT
cord-300872-blycbi4u	68	10	results	result	NNS
cord-300872-blycbi4u	68	11	showed	show	VBD
cord-300872-blycbi4u	68	12	that	that	IN
cord-300872-blycbi4u	68	13	these	these	DT
cord-300872-blycbi4u	68	14	two	two	CD
cord-300872-blycbi4u	68	15	derivatives	derivative	NNS
cord-300872-blycbi4u	68	16	are	be	VBP
cord-300872-blycbi4u	68	17	not	not	RB
cord-300872-blycbi4u	68	18	virucidal	virucidal	JJ
cord-300872-blycbi4u	68	19	,	,	,
cord-300872-blycbi4u	68	20	but	but	CC
cord-300872-blycbi4u	68	21	appear	appear	VBP
cord-300872-blycbi4u	68	22	to	to	TO
cord-300872-blycbi4u	68	23	act	act	VB
cord-300872-blycbi4u	68	24	at	at	IN
cord-300872-blycbi4u	68	25	an	an	DT
cord-300872-blycbi4u	68	26	early	early	JJ
cord-300872-blycbi4u	68	27	stage	stage	NN
cord-300872-blycbi4u	68	28	of	of	IN
cord-300872-blycbi4u	68	29	the	the	DT
cord-300872-blycbi4u	68	30	virus	virus	NN
cord-300872-blycbi4u	68	31	lifecycle	lifecycle	NN
cord-300872-blycbi4u	68	32	,	,	,
cord-300872-blycbi4u	68	33	reducing	reduce	VBG
cord-300872-blycbi4u	68	34	the	the	DT
cord-300872-blycbi4u	68	35	intracellular	intracellular	JJ
cord-300872-blycbi4u	68	36	production	production	NN
cord-300872-blycbi4u	68	37	of	of	IN
cord-300872-blycbi4u	68	38	the	the	DT
cord-300872-blycbi4u	68	39	envelope	envelope	NN
cord-300872-blycbi4u	68	40	glycoprotein	glycoprotein	NN
cord-300872-blycbi4u	68	41	and	and	CC
cord-300872-blycbi4u	68	42	the	the	DT
cord-300872-blycbi4u	68	43	yield	yield	NN
cord-300872-blycbi4u	68	44	of	of	IN
cord-300872-blycbi4u	68	45	infectious	infectious	JJ
cord-300872-blycbi4u	68	46	virions	virion	NNS
cord-300872-blycbi4u	68	47	in	in	IN
cord-300872-blycbi4u	68	48	treated	treat	VBN
cord-300872-blycbi4u	68	49	and	and	CC
cord-300872-blycbi4u	68	50	infected	infected	JJ
cord-300872-blycbi4u	68	51	cells	cell	NNS
cord-300872-blycbi4u	68	52	.	.	.
cord-300872-blycbi4u	69	1	In	in	IN
cord-300872-blycbi4u	69	2	a	a	DT
cord-300872-blycbi4u	69	3	similar	similar	JJ
cord-300872-blycbi4u	69	4	fashion	fashion	NN
cord-300872-blycbi4u	69	5	,	,	,
cord-300872-blycbi4u	69	6	Kos	Kos	NNP
cord-300872-blycbi4u	69	7	and	and	CC
cord-300872-blycbi4u	69	8	coworkers	coworker	NNS
cord-300872-blycbi4u	69	9	reported	report	VBD
cord-300872-blycbi4u	69	10	the	the	DT
cord-300872-blycbi4u	69	11	microwave	microwave	NN
cord-300872-blycbi4u	69	12	-	-	HYPH
cord-300872-blycbi4u	69	13	assisted	assist	VBN
cord-300872-blycbi4u	69	14	synthesis	synthesis	NN
cord-300872-blycbi4u	69	15	of	of	IN
cord-300872-blycbi4u	69	16	thirty	thirty	CD
cord-300872-blycbi4u	69	17	-	-	HYPH
cord-300872-blycbi4u	69	18	two	two	CD
cord-300872-blycbi4u	69	19	mono-	mono-	NN
cord-300872-blycbi4u	69	20	,	,	,
cord-300872-blycbi4u	69	21	di-	di-	XX
cord-300872-blycbi4u	69	22	,	,	,
cord-300872-blycbi4u	69	23	and	and	CC
cord-300872-blycbi4u	69	24	tri	tri	JJ
cord-300872-blycbi4u	69	25	-	-	JJ
cord-300872-blycbi4u	69	26	substituted	substitute	VBN
cord-300872-blycbi4u	69	27	8-hydroxyquinoline-2-carboxanilides	8-hydroxyquinoline-2-carboxanilides	CD
cord-300872-blycbi4u	69	28	,	,	,
cord-300872-blycbi4u	69	29	as	as	IN
cord-300872-blycbi4u	69	30	shown	show	VBN
cord-300872-blycbi4u	69	31	in	in	IN
cord-300872-blycbi4u	69	32	Scheme	scheme	NN
cord-300872-blycbi4u	69	33	2	2	CD
cord-300872-blycbi4u	69	34	[	[	-LRB-
cord-300872-blycbi4u	69	35	8	8	CD
cord-300872-blycbi4u	69	36	]	]	-RRB-
cord-300872-blycbi4u	69	37	.	.	.
cord-300872-blycbi4u	70	1	Condensation	condensation	NN
cord-300872-blycbi4u	70	2	of	of	IN
cord-300872-blycbi4u	70	3	activated	activate	VBN
cord-300872-blycbi4u	70	4	8-hydroxyquinoline-2-carboxylic	8-hydroxyquinoline-2-carboxylic	CD
cord-300872-blycbi4u	70	5	acid	acid	NN
cord-300872-blycbi4u	70	6	(	(	-LRB-
cord-300872-blycbi4u	70	7	5	5	CD
cord-300872-blycbi4u	70	8	)	)	-RRB-
cord-300872-blycbi4u	70	9	with	with	IN
cord-300872-blycbi4u	70	10	substituted	substitute	VBN
cord-300872-blycbi4u	70	11	aniline	aniline	NN
cord-300872-blycbi4u	70	12	6	6	CD
cord-300872-blycbi4u	70	13	in	in	IN
cord-300872-blycbi4u	70	14	the	the	DT
cord-300872-blycbi4u	70	15	presence	presence	NN
cord-300872-blycbi4u	70	16	of	of	IN
cord-300872-blycbi4u	70	17	by	by	IN
cord-300872-blycbi4u	70	18	phosphorus	phosphorus	NN
cord-300872-blycbi4u	70	19	trichloride	trichloride	NN
cord-300872-blycbi4u	70	20	yielded	yield	VBD
cord-300872-blycbi4u	70	21	the	the	DT
cord-300872-blycbi4u	70	22	desired	desire	VBN
cord-300872-blycbi4u	70	23	target	target	NN
cord-300872-blycbi4u	70	24	compound	compound	NN
cord-300872-blycbi4u	70	25	7	7	CD
cord-300872-blycbi4u	70	26	in	in	IN
cord-300872-blycbi4u	70	27	good	good	JJ
cord-300872-blycbi4u	70	28	amounts	amount	NNS
cord-300872-blycbi4u	70	29	(	(	-LRB-
cord-300872-blycbi4u	70	30	61	61	CD
cord-300872-blycbi4u	70	31	-	-	SYM
cord-300872-blycbi4u	70	32	79	79	CD
cord-300872-blycbi4u	70	33	%	%	NN
cord-300872-blycbi4u	70	34	)	)	-RRB-
cord-300872-blycbi4u	70	35	.	.	.
cord-300872-blycbi4u	71	1	These	these	DT
cord-300872-blycbi4u	71	2	prepared	prepared	JJ
cord-300872-blycbi4u	71	3	compounds	compound	NNS
cord-300872-blycbi4u	71	4	were	be	VBD
cord-300872-blycbi4u	71	5	subjected	subject	VBN
cord-300872-blycbi4u	71	6	to	to	IN
cord-300872-blycbi4u	71	7	bioactivity	bioactivity	NN
cord-300872-blycbi4u	71	8	screening	screening	NN
cord-300872-blycbi4u	71	9	against	against	IN
cord-300872-blycbi4u	71	10	the	the	DT
cord-300872-blycbi4u	71	11	highly	highly	RB
cord-300872-blycbi4u	71	12	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	71	13	H5N1	H5N1	NNP
cord-300872-blycbi4u	71	14	avian	avian	JJ
cord-300872-blycbi4u	71	15	influenza	influenza	NN
cord-300872-blycbi4u	71	16	viruses	virus	NNS
cord-300872-blycbi4u	71	17	,	,	,
cord-300872-blycbi4u	71	18	with	with	IN
cord-300872-blycbi4u	71	19	the	the	DT
cord-300872-blycbi4u	71	20	results	result	NNS
cord-300872-blycbi4u	71	21	expressed	express	VBN
cord-300872-blycbi4u	71	22	as	as	IN
cord-300872-blycbi4u	71	23	percentages	percentage	NNS
cord-300872-blycbi4u	71	24	of	of	IN
cord-300872-blycbi4u	71	25	growth	growth	NN
cord-300872-blycbi4u	71	26	inhibition	inhibition	NN
cord-300872-blycbi4u	71	27	,	,	,
cord-300872-blycbi4u	71	28	and	and	CC
cord-300872-blycbi4u	71	29	to	to	IN
cord-300872-blycbi4u	71	30	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	71	31	evaluation	evaluation	NN
cord-300872-blycbi4u	71	32	against	against	IN
cord-300872-blycbi4u	71	33	the	the	DT
cord-300872-blycbi4u	71	34	A549	a549	JJ
cord-300872-blycbi4u	71	35	cell	cell	NN
cord-300872-blycbi4u	71	36	line	line	NN
cord-300872-blycbi4u	71	37	.	.	.
cord-300872-blycbi4u	72	1	The	the	DT
cord-300872-blycbi4u	72	2	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	72	3	and	and	CC
cord-300872-blycbi4u	72	4	electronic	electronic	JJ
cord-300872-blycbi4u	72	5	properties	property	NNS
cord-300872-blycbi4u	72	6	were	be	VBD
cord-300872-blycbi4u	72	7	the	the	DT
cord-300872-blycbi4u	72	8	molecular	molecular	JJ
cord-300872-blycbi4u	72	9	parameters	parameter	NNS
cord-300872-blycbi4u	72	10	used	use	VBN
cord-300872-blycbi4u	72	11	to	to	TO
cord-300872-blycbi4u	72	12	determine	determine	VB
cord-300872-blycbi4u	72	13	the	the	DT
cord-300872-blycbi4u	72	14	structure	structure	NN
cord-300872-blycbi4u	72	15	-	-	HYPH
cord-300872-blycbi4u	72	16	activity	activity	NN
cord-300872-blycbi4u	72	17	relationship	relationship	NN
cord-300872-blycbi4u	72	18	.	.	.
cord-300872-blycbi4u	73	1	The	the	DT
cord-300872-blycbi4u	73	2	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	73	3	of	of	IN
cord-300872-blycbi4u	73	4	the	the	DT
cord-300872-blycbi4u	73	5	studied	study	VBN
cord-300872-blycbi4u	73	6	compounds	compound	NNS
cord-300872-blycbi4u	73	7	was	be	VBD
cord-300872-blycbi4u	73	8	determined	determine	VBN
cord-300872-blycbi4u	73	9	as	as	IN
cord-300872-blycbi4u	73	10	a	a	DT
cord-300872-blycbi4u	73	11	log	log	NN
cord-300872-blycbi4u	73	12	k	k	NN
cord-300872-blycbi4u	73	13	value	value	NN
cord-300872-blycbi4u	73	14	using	use	VBG
cord-300872-blycbi4u	73	15	reversed	reverse	VBN
cord-300872-blycbi4u	73	16	-	-	HYPH
cord-300872-blycbi4u	73	17	phase	phase	NN
cord-300872-blycbi4u	73	18	highperformance	highperformance	JJ
cord-300872-blycbi4u	73	19	liquid	liquid	NN
cord-300872-blycbi4u	73	20	chromatography	chromatography	NN
cord-300872-blycbi4u	73	21	(	(	-LRB-
cord-300872-blycbi4u	73	22	RP	rp	NN
cord-300872-blycbi4u	73	23	-	-	HYPH
cord-300872-blycbi4u	73	24	HPLC	HPLC	NNP
cord-300872-blycbi4u	73	25	)	)	-RRB-
cord-300872-blycbi4u	73	26	.	.	.
cord-300872-blycbi4u	74	1	Based	base	VBN
cord-300872-blycbi4u	74	2	on	on	IN
cord-300872-blycbi4u	74	3	the	the	DT
cord-300872-blycbi4u	74	4	presented	present	VBN
cord-300872-blycbi4u	74	5	results	result	NNS
cord-300872-blycbi4u	74	6	,	,	,
cord-300872-blycbi4u	74	7	most	most	JJS
cord-300872-blycbi4u	74	8	monosubstituted	monosubstituted	JJ
cord-300872-blycbi4u	74	9	derivatives	derivative	NNS
cord-300872-blycbi4u	74	10	did	do	VBD
cord-300872-blycbi4u	74	11	not	not	RB
cord-300872-blycbi4u	74	12	exert	exert	VB
cord-300872-blycbi4u	74	13	any	any	DT
cord-300872-blycbi4u	74	14	antiviral	antiviral	JJ
cord-300872-blycbi4u	74	15	activity	activity	NN
cord-300872-blycbi4u	74	16	or	or	CC
cord-300872-blycbi4u	74	17	demonstrated	demonstrate	VBN
cord-300872-blycbi4u	74	18	only	only	JJ
cord-300872-blycbi4u	74	19	moderate	moderate	JJ
cord-300872-blycbi4u	74	20	activity	activity	NN
cord-300872-blycbi4u	74	21	.	.	.
cord-300872-blycbi4u	75	1	For	for	IN
cord-300872-blycbi4u	75	2	example	example	NN
cord-300872-blycbi4u	75	3	,	,	,
cord-300872-blycbi4u	75	4	8-hydroxy	8-hydroxy	CD
cord-300872-blycbi4u	75	5	-	-	HYPH
cord-300872-blycbi4u	75	6	N-(3-nitrophenyl)quinoline-2-carboxamide	n-(3-nitrophenyl)quinoline-2-carboxamide	NN
cord-300872-blycbi4u	75	7	showed	show	VBD
cord-300872-blycbi4u	75	8	optimum	optimum	JJ
cord-300872-blycbi4u	75	9	virus	virus	NN
cord-300872-blycbi4u	75	10	growth	growth	NN
cord-300872-blycbi4u	75	11	inhibition	inhibition	NN
cord-300872-blycbi4u	75	12	activity	activity	NN
cord-300872-blycbi4u	75	13	and	and	CC
cord-300872-blycbi4u	75	14	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	75	15	values	value	NNS
cord-300872-blycbi4u	75	16	of	of	IN
cord-300872-blycbi4u	75	17	85.0	85.0	CD
cord-300872-blycbi4u	75	18	%	%	NN
cord-300872-blycbi4u	75	19	and	and	CC
cord-300872-blycbi4u	75	20	4	4	CD
cord-300872-blycbi4u	75	21	%	%	NN
cord-300872-blycbi4u	75	22	,	,	,
cord-300872-blycbi4u	75	23	respectively	respectively	RB
cord-300872-blycbi4u	75	24	.	.	.
cord-300872-blycbi4u	76	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	76	2	,	,	,
cord-300872-blycbi4u	76	3	the	the	DT
cord-300872-blycbi4u	76	4	results	result	NNS
cord-300872-blycbi4u	76	5	show	show	VBP
cord-300872-blycbi4u	76	6	that	that	IN
cord-300872-blycbi4u	76	7	the	the	DT
cord-300872-blycbi4u	76	8	antiviral	antiviral	JJ
cord-300872-blycbi4u	76	9	activity	activity	NN
cord-300872-blycbi4u	76	10	is	be	VBZ
cord-300872-blycbi4u	76	11	influenced	influence	VBN
cord-300872-blycbi4u	76	12	by	by	IN
cord-300872-blycbi4u	76	13	increasing	increase	VBG
cord-300872-blycbi4u	76	14	the	the	DT
cord-300872-blycbi4u	76	15	electron	electron	NN
cord-300872-blycbi4u	76	16	-	-	HYPH
cord-300872-blycbi4u	76	17	withdrawing	withdraw	VBG
cord-300872-blycbi4u	76	18	properties	property	NNS
cord-300872-blycbi4u	76	19	of	of	IN
cord-300872-blycbi4u	76	20	substituents	substituent	NNS
cord-300872-blycbi4u	76	21	on	on	IN
cord-300872-blycbi4u	76	22	the	the	DT
cord-300872-blycbi4u	76	23	anilide	anilide	NNP
cord-300872-blycbi4u	76	24	ring	ring	NN
cord-300872-blycbi4u	76	25	and	and	CC
cord-300872-blycbi4u	76	26	is	be	VBZ
cord-300872-blycbi4u	76	27	positively	positively	RB
cord-300872-blycbi4u	76	28	influenced	influence	VBN
cord-300872-blycbi4u	76	29	by	by	IN
cord-300872-blycbi4u	76	30	increasing	increase	VBG
cord-300872-blycbi4u	76	31	the	the	DT
cord-300872-blycbi4u	76	32	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	76	33	;	;	:
cord-300872-blycbi4u	76	34	in	in	IN
cord-300872-blycbi4u	76	35	this	this	DT
cord-300872-blycbi4u	76	36	manner	manner	NN
cord-300872-blycbi4u	76	37	,	,	,
cord-300872-blycbi4u	76	38	the	the	DT
cord-300872-blycbi4u	76	39	derivative	derivative	JJ
cord-300872-blycbi4u	76	40	showing	show	VBG
cord-300872-blycbi4u	76	41	values	value	NNS
cord-300872-blycbi4u	76	42	of	of	IN
cord-300872-blycbi4u	76	43	R	r	NN
cord-300872-blycbi4u	76	44	=	=	SYM
cord-300872-blycbi4u	76	45	3-NO2	3-no2	CD
cord-300872-blycbi4u	76	46	and	and	CC
cord-300872-blycbi4u	76	47	log	log	NN
cord-300872-blycbi4u	76	48	k	k	NN
cord-300872-blycbi4u	76	49	=	=	SYM
cord-300872-blycbi4u	76	50	ca	ca	NN
cord-300872-blycbi4u	76	51	.	.	.
cord-300872-blycbi4u	77	1	0.41	0.41	CD
cord-300872-blycbi4u	77	2	showed	show	VBD
cord-300872-blycbi4u	77	3	maximal	maximal	JJ
cord-300872-blycbi4u	77	4	activity	activity	NN
cord-300872-blycbi4u	77	5	with	with	IN
cord-300872-blycbi4u	77	6	insignificant	insignificant	JJ
cord-300872-blycbi4u	77	7	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	77	8	.	.	.
cord-300872-blycbi4u	78	1	Di	Di	NNP
cord-300872-blycbi4u	78	2	-	-	HYPH
cord-300872-blycbi4u	78	3	and	and	CC
cord-300872-blycbi4u	78	4	tri	tri	JJ
cord-300872-blycbi4u	78	5	-	-	JJ
cord-300872-blycbi4u	78	6	substituted	substitute	VBN
cord-300872-blycbi4u	78	7	derivatives	derivative	NNS
cord-300872-blycbi4u	78	8	(	(	-LRB-
cord-300872-blycbi4u	78	9	R	r	NN
cord-300872-blycbi4u	78	10	=	=	SYM
cord-300872-blycbi4u	78	11	3,4-Cl	3,4-cl	CD
cord-300872-blycbi4u	78	12	,	,	,
cord-300872-blycbi4u	78	13	3,4,5-Cl	3,4,5-cl	CD
cord-300872-blycbi4u	78	14	,	,	,
cord-300872-blycbi4u	78	15	3-Cl-2-F	3-cl-2-f	CD
cord-300872-blycbi4u	78	16	,	,	,
cord-300872-blycbi4u	78	17	and	and	CC
cord-300872-blycbi4u	78	18	2,4-NO2	2,4-no2	CD
cord-300872-blycbi4u	78	19	)	)	-RRB-
cord-300872-blycbi4u	78	20	showed	show	VBD
cord-300872-blycbi4u	78	21	higher	high	JJR
cord-300872-blycbi4u	78	22	inhibition	inhibition	NN
cord-300872-blycbi4u	78	23	of	of	IN
cord-300872-blycbi4u	78	24	H5N1	H5N1	NNP
cord-300872-blycbi4u	78	25	growth	growth	NN
cord-300872-blycbi4u	78	26	and	and	CC
cord-300872-blycbi4u	78	27	simultaneous	simultaneous	JJ
cord-300872-blycbi4u	78	28	low	low	JJ
cord-300872-blycbi4u	78	29	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	78	30	.	.	.
cord-300872-blycbi4u	79	1	For	for	IN
cord-300872-blycbi4u	79	2	example	example	NN
cord-300872-blycbi4u	79	3	,	,	,
cord-300872-blycbi4u	79	4	3-Cl-2-F	3-cl-2-f	CD
cord-300872-blycbi4u	79	5	and	and	CC
cord-300872-blycbi4u	79	6	3,4,5-Cl	3,4,5-cl	CD
cord-300872-blycbi4u	79	7	exhibited	exhibit	VBD
cord-300872-blycbi4u	79	8	virus	virus	NN
cord-300872-blycbi4u	79	9	growth	growth	NN
cord-300872-blycbi4u	79	10	inhibition	inhibition	NN
cord-300872-blycbi4u	79	11	activity	activity	NN
cord-300872-blycbi4u	79	12	values	value	NNS
cord-300872-blycbi4u	79	13	of	of	IN
cord-300872-blycbi4u	79	14	91.2	91.2	CD
cord-300872-blycbi4u	79	15	and	and	CC
cord-300872-blycbi4u	79	16	9.7	9.7	CD
cord-300872-blycbi4u	79	17	%	%	NN
cord-300872-blycbi4u	79	18	and	and	CC
cord-300872-blycbi4u	79	19	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	79	20	values	value	NNS
cord-300872-blycbi4u	79	21	of	of	IN
cord-300872-blycbi4u	79	22	79.3	79.3	CD
cord-300872-blycbi4u	79	23	and	and	CC
cord-300872-blycbi4u	79	24	2.4	2.4	CD
cord-300872-blycbi4u	79	25	%	%	NN
cord-300872-blycbi4u	79	26	,	,	,
cord-300872-blycbi4u	79	27	respectively	respectively	RB
cord-300872-blycbi4u	79	28	;	;	:
cord-300872-blycbi4u	79	29	the	the	DT
cord-300872-blycbi4u	79	30	log	log	NN
cord-300872-blycbi4u	79	31	k	k	NN
cord-300872-blycbi4u	79	32	values	value	NNS
cord-300872-blycbi4u	79	33	for	for	IN
cord-300872-blycbi4u	79	34	these	these	DT
cord-300872-blycbi4u	79	35	derivatives	derivative	NNS
cord-300872-blycbi4u	79	36	were	be	VBD
cord-300872-blycbi4u	79	37	1.44	1.44	CD
cord-300872-blycbi4u	79	38	and	and	CC
cord-300872-blycbi4u	79	39	1.26	1.26	CD
cord-300872-blycbi4u	79	40	,	,	,
cord-300872-blycbi4u	79	41	respectively	respectively	RB
cord-300872-blycbi4u	79	42	.	.	.
cord-300872-blycbi4u	80	1	The	the	DT
cord-300872-blycbi4u	80	2	study	study	NN
cord-300872-blycbi4u	80	3	indicated	indicate	VBD
cord-300872-blycbi4u	80	4	that	that	IN
cord-300872-blycbi4u	80	5	the	the	DT
cord-300872-blycbi4u	80	6	antiviral	antiviral	JJ
cord-300872-blycbi4u	80	7	activity	activity	NN
cord-300872-blycbi4u	80	8	linearly	linearly	RB
cord-300872-blycbi4u	80	9	increases	increase	VBZ
cord-300872-blycbi4u	80	10	with	with	IN
cord-300872-blycbi4u	80	11	increasing	increase	VBG
cord-300872-blycbi4u	80	12	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	80	13	and	and	CC
cord-300872-blycbi4u	80	14	is	be	VBZ
cord-300872-blycbi4u	80	15	positively	positively	RB
cord-300872-blycbi4u	80	16	influenced	influence	VBN
cord-300872-blycbi4u	80	17	by	by	IN
cord-300872-blycbi4u	80	18	increasing	increase	VBG
cord-300872-blycbi4u	80	19	the	the	DT
cord-300872-blycbi4u	80	20	electron	electron	NN
cord-300872-blycbi4u	80	21	-	-	HYPH
cord-300872-blycbi4u	80	22	withdrawing	withdraw	VBG
cord-300872-blycbi4u	80	23	properties	property	NNS
cord-300872-blycbi4u	80	24	of	of	IN
cord-300872-blycbi4u	80	25	substituents	substituent	NNS
cord-300872-blycbi4u	80	26	on	on	IN
cord-300872-blycbi4u	80	27	the	the	DT
cord-300872-blycbi4u	80	28	anilide	anilide	NNP
cord-300872-blycbi4u	80	29	ring	ring	NN
cord-300872-blycbi4u	80	30	.	.	.
cord-300872-blycbi4u	81	1	With	with	IN
cord-300872-blycbi4u	81	2	the	the	DT
cord-300872-blycbi4u	81	3	frantic	frantic	JJ
cord-300872-blycbi4u	81	4	search	search	NN
cord-300872-blycbi4u	81	5	for	for	IN
cord-300872-blycbi4u	81	6	drugs	drug	NNS
cord-300872-blycbi4u	81	7	to	to	TO
cord-300872-blycbi4u	81	8	treat	treat	VB
cord-300872-blycbi4u	81	9	COVID-19	covid-19	JJ
cord-300872-blycbi4u	81	10	patients	patient	NNS
cord-300872-blycbi4u	81	11	and	and	CC
cord-300872-blycbi4u	81	12	ultimately	ultimately	RB
cord-300872-blycbi4u	81	13	for	for	IN
cord-300872-blycbi4u	81	14	a	a	DT
cord-300872-blycbi4u	81	15	COVID-19	covid-19	JJ
cord-300872-blycbi4u	81	16	vaccine	vaccine	NN
cord-300872-blycbi4u	81	17	,	,	,
cord-300872-blycbi4u	81	18	the	the	DT
cord-300872-blycbi4u	81	19	8-HQ	8-hq	CD
cord-300872-blycbi4u	81	20	nucleus	nucleus	NN
cord-300872-blycbi4u	81	21	could	could	MD
cord-300872-blycbi4u	81	22	play	play	VB
cord-300872-blycbi4u	81	23	a	a	DT
cord-300872-blycbi4u	81	24	role	role	NN
cord-300872-blycbi4u	81	25	in	in	IN
cord-300872-blycbi4u	81	26	this	this	DT
cord-300872-blycbi4u	81	27	due	due	IN
cord-300872-blycbi4u	81	28	to	to	IN
cord-300872-blycbi4u	81	29	its	-PRON-	PRP$
cord-300872-blycbi4u	81	30	promising	promising	JJ
cord-300872-blycbi4u	81	31	antiviral	antiviral	JJ
cord-300872-blycbi4u	81	32	activity	activity	NN
cord-300872-blycbi4u	81	33	;	;	:
cord-300872-blycbi4u	81	34	however	however	RB
cord-300872-blycbi4u	81	35	,	,	,
cord-300872-blycbi4u	81	36	more	more	JJR
cord-300872-blycbi4u	81	37	research	research	NN
cord-300872-blycbi4u	81	38	is	be	VBZ
cord-300872-blycbi4u	81	39	required	require	VBN
cord-300872-blycbi4u	81	40	in	in	IN
cord-300872-blycbi4u	81	41	this	this	DT
cord-300872-blycbi4u	81	42	area	area	NN
cord-300872-blycbi4u	81	43	.	.	.
cord-300872-blycbi4u	82	1	The	the	DT
cord-300872-blycbi4u	82	2	spread	spread	NN
cord-300872-blycbi4u	82	3	of	of	IN
cord-300872-blycbi4u	82	4	the	the	DT
cord-300872-blycbi4u	82	5	antibiotic	antibiotic	JJ
cord-300872-blycbi4u	82	6	-	-	HYPH
cord-300872-blycbi4u	82	7	resistant	resistant	JJ
cord-300872-blycbi4u	82	8	bacterial	bacterial	JJ
cord-300872-blycbi4u	82	9	strains	strain	NNS
cord-300872-blycbi4u	82	10	constitutes	constitute	VBZ
cord-300872-blycbi4u	82	11	a	a	DT
cord-300872-blycbi4u	82	12	serious	serious	JJ
cord-300872-blycbi4u	82	13	threat	threat	NN
cord-300872-blycbi4u	82	14	to	to	IN
cord-300872-blycbi4u	82	15	public	public	JJ
cord-300872-blycbi4u	82	16	health	health	NN
cord-300872-blycbi4u	82	17	.	.	.
cord-300872-blycbi4u	83	1	Some	some	DT
cord-300872-blycbi4u	83	2	of	of	IN
cord-300872-blycbi4u	83	3	these	these	DT
cord-300872-blycbi4u	83	4	strains	strain	NNS
cord-300872-blycbi4u	83	5	have	have	VBP
cord-300872-blycbi4u	83	6	even	even	RB
cord-300872-blycbi4u	83	7	become	become	VBN
cord-300872-blycbi4u	83	8	resistant	resistant	JJ
cord-300872-blycbi4u	83	9	to	to	IN
cord-300872-blycbi4u	83	10	many	many	JJ
cord-300872-blycbi4u	83	11	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	83	12	and	and	CC
cord-300872-blycbi4u	83	13	chemotherapeutic	chemotherapeutic	JJ
cord-300872-blycbi4u	83	14	agents	agent	NNS
cord-300872-blycbi4u	83	15	;	;	:
cord-300872-blycbi4u	83	16	These	these	DT
cord-300872-blycbi4u	83	17	prepared	prepared	JJ
cord-300872-blycbi4u	83	18	compounds	compound	NNS
cord-300872-blycbi4u	83	19	were	be	VBD
cord-300872-blycbi4u	83	20	subjected	subject	VBN
cord-300872-blycbi4u	83	21	to	to	IN
cord-300872-blycbi4u	83	22	bioactivity	bioactivity	NN
cord-300872-blycbi4u	83	23	screening	screening	NN
cord-300872-blycbi4u	83	24	against	against	IN
cord-300872-blycbi4u	83	25	the	the	DT
cord-300872-blycbi4u	83	26	highly	highly	RB
cord-300872-blycbi4u	83	27	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	83	28	H5N1	H5N1	NNP
cord-300872-blycbi4u	83	29	avian	avian	JJ
cord-300872-blycbi4u	83	30	influenza	influenza	NN
cord-300872-blycbi4u	83	31	viruses	virus	NNS
cord-300872-blycbi4u	83	32	,	,	,
cord-300872-blycbi4u	83	33	with	with	IN
cord-300872-blycbi4u	83	34	the	the	DT
cord-300872-blycbi4u	83	35	results	result	NNS
cord-300872-blycbi4u	83	36	expressed	express	VBN
cord-300872-blycbi4u	83	37	as	as	IN
cord-300872-blycbi4u	83	38	percentages	percentage	NNS
cord-300872-blycbi4u	83	39	of	of	IN
cord-300872-blycbi4u	83	40	growth	growth	NN
cord-300872-blycbi4u	83	41	inhibition	inhibition	NN
cord-300872-blycbi4u	83	42	,	,	,
cord-300872-blycbi4u	83	43	and	and	CC
cord-300872-blycbi4u	83	44	to	to	IN
cord-300872-blycbi4u	83	45	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	83	46	evaluation	evaluation	NN
cord-300872-blycbi4u	83	47	against	against	IN
cord-300872-blycbi4u	83	48	the	the	DT
cord-300872-blycbi4u	83	49	A549	a549	JJ
cord-300872-blycbi4u	83	50	cell	cell	NN
cord-300872-blycbi4u	83	51	line	line	NN
cord-300872-blycbi4u	83	52	.	.	.
cord-300872-blycbi4u	84	1	The	the	DT
cord-300872-blycbi4u	84	2	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	84	3	and	and	CC
cord-300872-blycbi4u	84	4	electronic	electronic	JJ
cord-300872-blycbi4u	84	5	properties	property	NNS
cord-300872-blycbi4u	84	6	were	be	VBD
cord-300872-blycbi4u	84	7	the	the	DT
cord-300872-blycbi4u	84	8	molecular	molecular	JJ
cord-300872-blycbi4u	84	9	parameters	parameter	NNS
cord-300872-blycbi4u	84	10	used	use	VBN
cord-300872-blycbi4u	84	11	to	to	TO
cord-300872-blycbi4u	84	12	determine	determine	VB
cord-300872-blycbi4u	84	13	the	the	DT
cord-300872-blycbi4u	84	14	structure	structure	NN
cord-300872-blycbi4u	84	15	-	-	HYPH
cord-300872-blycbi4u	84	16	activity	activity	NN
cord-300872-blycbi4u	84	17	relationship	relationship	NN
cord-300872-blycbi4u	84	18	.	.	.
cord-300872-blycbi4u	85	1	The	the	DT
cord-300872-blycbi4u	85	2	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	85	3	of	of	IN
cord-300872-blycbi4u	85	4	the	the	DT
cord-300872-blycbi4u	85	5	studied	study	VBN
cord-300872-blycbi4u	85	6	compounds	compound	NNS
cord-300872-blycbi4u	85	7	was	be	VBD
cord-300872-blycbi4u	85	8	determined	determine	VBN
cord-300872-blycbi4u	85	9	as	as	IN
cord-300872-blycbi4u	85	10	a	a	DT
cord-300872-blycbi4u	85	11	log	log	NN
cord-300872-blycbi4u	85	12	k	k	NN
cord-300872-blycbi4u	85	13	value	value	NN
cord-300872-blycbi4u	85	14	using	use	VBG
cord-300872-blycbi4u	85	15	reversed	reverse	VBN
cord-300872-blycbi4u	85	16	-	-	HYPH
cord-300872-blycbi4u	85	17	phase	phase	NN
cord-300872-blycbi4u	85	18	high	high	JJ
cord-300872-blycbi4u	85	19	-	-	HYPH
cord-300872-blycbi4u	85	20	performance	performance	NN
cord-300872-blycbi4u	85	21	liquid	liquid	NN
cord-300872-blycbi4u	85	22	chromatography	chromatography	NN
cord-300872-blycbi4u	85	23	(	(	-LRB-
cord-300872-blycbi4u	85	24	RP	rp	NN
cord-300872-blycbi4u	85	25	-	-	HYPH
cord-300872-blycbi4u	85	26	HPLC	HPLC	NNP
cord-300872-blycbi4u	85	27	)	)	-RRB-
cord-300872-blycbi4u	85	28	.	.	.
cord-300872-blycbi4u	86	1	Based	base	VBN
cord-300872-blycbi4u	86	2	on	on	IN
cord-300872-blycbi4u	86	3	the	the	DT
cord-300872-blycbi4u	86	4	presented	present	VBN
cord-300872-blycbi4u	86	5	results	result	NNS
cord-300872-blycbi4u	86	6	,	,	,
cord-300872-blycbi4u	86	7	most	most	JJS
cord-300872-blycbi4u	86	8	mono	mono	NN
cord-300872-blycbi4u	86	9	-	-	HYPH
cord-300872-blycbi4u	86	10	substituted	substitute	VBN
cord-300872-blycbi4u	86	11	derivatives	derivative	NNS
cord-300872-blycbi4u	86	12	did	do	VBD
cord-300872-blycbi4u	86	13	not	not	RB
cord-300872-blycbi4u	86	14	exert	exert	VB
cord-300872-blycbi4u	86	15	any	any	DT
cord-300872-blycbi4u	86	16	antiviral	antiviral	JJ
cord-300872-blycbi4u	86	17	activity	activity	NN
cord-300872-blycbi4u	86	18	or	or	CC
cord-300872-blycbi4u	86	19	demonstrated	demonstrate	VBN
cord-300872-blycbi4u	86	20	only	only	JJ
cord-300872-blycbi4u	86	21	moderate	moderate	JJ
cord-300872-blycbi4u	86	22	activity	activity	NN
cord-300872-blycbi4u	86	23	.	.	.
cord-300872-blycbi4u	87	1	For	for	IN
cord-300872-blycbi4u	87	2	example	example	NN
cord-300872-blycbi4u	87	3	,	,	,
cord-300872-blycbi4u	87	4	8-hydroxy	8-hydroxy	CD
cord-300872-blycbi4u	87	5	-	-	HYPH
cord-300872-blycbi4u	87	6	N-(3-nitrophenyl)quinoline-2-carboxamide	n-(3-nitrophenyl)quinoline-2-carboxamide	NN
cord-300872-blycbi4u	87	7	showed	show	VBD
cord-300872-blycbi4u	87	8	optimum	optimum	JJ
cord-300872-blycbi4u	87	9	virus	virus	NN
cord-300872-blycbi4u	87	10	growth	growth	NN
cord-300872-blycbi4u	87	11	inhibition	inhibition	NN
cord-300872-blycbi4u	87	12	activity	activity	NN
cord-300872-blycbi4u	87	13	and	and	CC
cord-300872-blycbi4u	87	14	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	87	15	values	value	NNS
cord-300872-blycbi4u	87	16	of	of	IN
cord-300872-blycbi4u	87	17	85.0	85.0	CD
cord-300872-blycbi4u	87	18	%	%	NN
cord-300872-blycbi4u	87	19	and	and	CC
cord-300872-blycbi4u	87	20	4	4	CD
cord-300872-blycbi4u	87	21	%	%	NN
cord-300872-blycbi4u	87	22	,	,	,
cord-300872-blycbi4u	87	23	respectively	respectively	RB
cord-300872-blycbi4u	87	24	.	.	.
cord-300872-blycbi4u	88	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	88	2	,	,	,
cord-300872-blycbi4u	88	3	the	the	DT
cord-300872-blycbi4u	88	4	results	result	NNS
cord-300872-blycbi4u	88	5	show	show	VBP
cord-300872-blycbi4u	88	6	that	that	IN
cord-300872-blycbi4u	88	7	the	the	DT
cord-300872-blycbi4u	88	8	antiviral	antiviral	JJ
cord-300872-blycbi4u	88	9	activity	activity	NN
cord-300872-blycbi4u	88	10	is	be	VBZ
cord-300872-blycbi4u	88	11	influenced	influence	VBN
cord-300872-blycbi4u	88	12	by	by	IN
cord-300872-blycbi4u	88	13	increasing	increase	VBG
cord-300872-blycbi4u	88	14	the	the	DT
cord-300872-blycbi4u	88	15	electron	electron	NN
cord-300872-blycbi4u	88	16	-	-	HYPH
cord-300872-blycbi4u	88	17	withdrawing	withdraw	VBG
cord-300872-blycbi4u	88	18	properties	property	NNS
cord-300872-blycbi4u	88	19	of	of	IN
cord-300872-blycbi4u	88	20	substituents	substituent	NNS
cord-300872-blycbi4u	88	21	on	on	IN
cord-300872-blycbi4u	88	22	the	the	DT
cord-300872-blycbi4u	88	23	anilide	anilide	NNP
cord-300872-blycbi4u	88	24	ring	ring	NN
cord-300872-blycbi4u	88	25	and	and	CC
cord-300872-blycbi4u	88	26	is	be	VBZ
cord-300872-blycbi4u	88	27	positively	positively	RB
cord-300872-blycbi4u	88	28	influenced	influence	VBN
cord-300872-blycbi4u	88	29	by	by	IN
cord-300872-blycbi4u	88	30	increasing	increase	VBG
cord-300872-blycbi4u	88	31	the	the	DT
cord-300872-blycbi4u	88	32	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	88	33	;	;	:
cord-300872-blycbi4u	88	34	in	in	IN
cord-300872-blycbi4u	88	35	this	this	DT
cord-300872-blycbi4u	88	36	manner	manner	NN
cord-300872-blycbi4u	88	37	,	,	,
cord-300872-blycbi4u	88	38	the	the	DT
cord-300872-blycbi4u	88	39	derivative	derivative	JJ
cord-300872-blycbi4u	88	40	showing	show	VBG
cord-300872-blycbi4u	88	41	values	value	NNS
cord-300872-blycbi4u	88	42	of	of	IN
cord-300872-blycbi4u	88	43	R	r	NN
cord-300872-blycbi4u	88	44	=	=	NFP
cord-300872-blycbi4u	89	1	3-NO	3-no	CD
cord-300872-blycbi4u	89	2	2	2	CD
cord-300872-blycbi4u	89	3	and	and	CC
cord-300872-blycbi4u	89	4	log	log	VB
cord-300872-blycbi4u	90	1	k	k	NNP
cord-300872-blycbi4u	90	2	=	=	SYM
cord-300872-blycbi4u	90	3	ca	ca	NNP
cord-300872-blycbi4u	90	4	.	.	.
cord-300872-blycbi4u	91	1	0.41	0.41	CD
cord-300872-blycbi4u	91	2	showed	show	VBD
cord-300872-blycbi4u	91	3	maximal	maximal	JJ
cord-300872-blycbi4u	91	4	activity	activity	NN
cord-300872-blycbi4u	91	5	with	with	IN
cord-300872-blycbi4u	91	6	insignificant	insignificant	JJ
cord-300872-blycbi4u	91	7	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	91	8	.	.	.
cord-300872-blycbi4u	92	1	Di	Di	NNP
cord-300872-blycbi4u	92	2	-	-	HYPH
cord-300872-blycbi4u	92	3	and	and	CC
cord-300872-blycbi4u	92	4	tri	tri	JJ
cord-300872-blycbi4u	92	5	-	-	JJ
cord-300872-blycbi4u	92	6	substituted	substitute	VBN
cord-300872-blycbi4u	92	7	derivatives	derivative	NNS
cord-300872-blycbi4u	92	8	(	(	-LRB-
cord-300872-blycbi4u	92	9	R	r	NN
cord-300872-blycbi4u	92	10	=	=	SYM
cord-300872-blycbi4u	92	11	3,4-Cl	3,4-cl	CD
cord-300872-blycbi4u	92	12	,	,	,
cord-300872-blycbi4u	92	13	3,4,5-Cl	3,4,5-cl	CD
cord-300872-blycbi4u	92	14	,	,	,
cord-300872-blycbi4u	92	15	3-Cl-2-F	3-cl-2-f	CD
cord-300872-blycbi4u	92	16	,	,	,
cord-300872-blycbi4u	92	17	and	and	CC
cord-300872-blycbi4u	92	18	2,4-NO	2,4-no	CD
cord-300872-blycbi4u	92	19	2	2	CD
cord-300872-blycbi4u	92	20	)	)	-RRB-
cord-300872-blycbi4u	92	21	showed	show	VBD
cord-300872-blycbi4u	92	22	higher	high	JJR
cord-300872-blycbi4u	92	23	inhibition	inhibition	NN
cord-300872-blycbi4u	92	24	of	of	IN
cord-300872-blycbi4u	92	25	H5N1	H5N1	NNP
cord-300872-blycbi4u	92	26	growth	growth	NN
cord-300872-blycbi4u	92	27	and	and	CC
cord-300872-blycbi4u	92	28	simultaneous	simultaneous	JJ
cord-300872-blycbi4u	92	29	low	low	JJ
cord-300872-blycbi4u	92	30	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	92	31	.	.	.
cord-300872-blycbi4u	93	1	For	for	IN
cord-300872-blycbi4u	93	2	example	example	NN
cord-300872-blycbi4u	93	3	,	,	,
cord-300872-blycbi4u	93	4	3-Cl-2-F	3-cl-2-f	CD
cord-300872-blycbi4u	93	5	and	and	CC
cord-300872-blycbi4u	93	6	3,4,5-Cl	3,4,5-cl	CD
cord-300872-blycbi4u	93	7	exhibited	exhibit	VBD
cord-300872-blycbi4u	93	8	virus	virus	NN
cord-300872-blycbi4u	93	9	growth	growth	NN
cord-300872-blycbi4u	93	10	inhibition	inhibition	NN
cord-300872-blycbi4u	93	11	activity	activity	NN
cord-300872-blycbi4u	93	12	values	value	NNS
cord-300872-blycbi4u	93	13	of	of	IN
cord-300872-blycbi4u	93	14	91.2	91.2	CD
cord-300872-blycbi4u	93	15	and	and	CC
cord-300872-blycbi4u	93	16	9.7	9.7	CD
cord-300872-blycbi4u	93	17	%	%	NN
cord-300872-blycbi4u	93	18	and	and	CC
cord-300872-blycbi4u	93	19	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	93	20	values	value	NNS
cord-300872-blycbi4u	93	21	of	of	IN
cord-300872-blycbi4u	93	22	79.3	79.3	CD
cord-300872-blycbi4u	93	23	and	and	CC
cord-300872-blycbi4u	93	24	2.4	2.4	CD
cord-300872-blycbi4u	93	25	%	%	NN
cord-300872-blycbi4u	93	26	,	,	,
cord-300872-blycbi4u	93	27	respectively	respectively	RB
cord-300872-blycbi4u	93	28	;	;	:
cord-300872-blycbi4u	93	29	the	the	DT
cord-300872-blycbi4u	93	30	log	log	NN
cord-300872-blycbi4u	93	31	k	k	NN
cord-300872-blycbi4u	93	32	values	value	NNS
cord-300872-blycbi4u	93	33	for	for	IN
cord-300872-blycbi4u	93	34	these	these	DT
cord-300872-blycbi4u	93	35	derivatives	derivative	NNS
cord-300872-blycbi4u	93	36	were	be	VBD
cord-300872-blycbi4u	93	37	1.44	1.44	CD
cord-300872-blycbi4u	93	38	and	and	CC
cord-300872-blycbi4u	93	39	1.26	1.26	CD
cord-300872-blycbi4u	93	40	,	,	,
cord-300872-blycbi4u	93	41	respectively	respectively	RB
cord-300872-blycbi4u	93	42	.	.	.
cord-300872-blycbi4u	94	1	The	the	DT
cord-300872-blycbi4u	94	2	study	study	NN
cord-300872-blycbi4u	94	3	indicated	indicate	VBD
cord-300872-blycbi4u	94	4	that	that	IN
cord-300872-blycbi4u	94	5	the	the	DT
cord-300872-blycbi4u	94	6	antiviral	antiviral	JJ
cord-300872-blycbi4u	94	7	activity	activity	NN
cord-300872-blycbi4u	94	8	linearly	linearly	RB
cord-300872-blycbi4u	94	9	increases	increase	VBZ
cord-300872-blycbi4u	94	10	with	with	IN
cord-300872-blycbi4u	94	11	increasing	increase	VBG
cord-300872-blycbi4u	94	12	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	94	13	and	and	CC
cord-300872-blycbi4u	94	14	is	be	VBZ
cord-300872-blycbi4u	94	15	positively	positively	RB
cord-300872-blycbi4u	94	16	influenced	influence	VBN
cord-300872-blycbi4u	94	17	by	by	IN
cord-300872-blycbi4u	94	18	increasing	increase	VBG
cord-300872-blycbi4u	94	19	the	the	DT
cord-300872-blycbi4u	94	20	electron	electron	NN
cord-300872-blycbi4u	94	21	-	-	HYPH
cord-300872-blycbi4u	94	22	withdrawing	withdraw	VBG
cord-300872-blycbi4u	94	23	properties	property	NNS
cord-300872-blycbi4u	94	24	of	of	IN
cord-300872-blycbi4u	94	25	substituents	substituent	NNS
cord-300872-blycbi4u	94	26	on	on	IN
cord-300872-blycbi4u	94	27	the	the	DT
cord-300872-blycbi4u	94	28	anilide	anilide	NNP
cord-300872-blycbi4u	94	29	ring	ring	NN
cord-300872-blycbi4u	94	30	.	.	.
cord-300872-blycbi4u	95	1	With	with	IN
cord-300872-blycbi4u	95	2	the	the	DT
cord-300872-blycbi4u	95	3	frantic	frantic	JJ
cord-300872-blycbi4u	95	4	search	search	NN
cord-300872-blycbi4u	95	5	for	for	IN
cord-300872-blycbi4u	95	6	drugs	drug	NNS
cord-300872-blycbi4u	95	7	to	to	TO
cord-300872-blycbi4u	95	8	treat	treat	VB
cord-300872-blycbi4u	95	9	COVID-19	covid-19	JJ
cord-300872-blycbi4u	95	10	patients	patient	NNS
cord-300872-blycbi4u	95	11	and	and	CC
cord-300872-blycbi4u	95	12	ultimately	ultimately	RB
cord-300872-blycbi4u	95	13	for	for	IN
cord-300872-blycbi4u	95	14	a	a	DT
cord-300872-blycbi4u	95	15	COVID-19	covid-19	JJ
cord-300872-blycbi4u	95	16	vaccine	vaccine	NN
cord-300872-blycbi4u	95	17	,	,	,
cord-300872-blycbi4u	95	18	the	the	DT
cord-300872-blycbi4u	95	19	8-HQ	8-hq	CD
cord-300872-blycbi4u	95	20	nucleus	nucleus	NN
cord-300872-blycbi4u	95	21	could	could	MD
cord-300872-blycbi4u	95	22	play	play	VB
cord-300872-blycbi4u	95	23	a	a	DT
cord-300872-blycbi4u	95	24	role	role	NN
cord-300872-blycbi4u	95	25	in	in	IN
cord-300872-blycbi4u	95	26	this	this	DT
cord-300872-blycbi4u	95	27	due	due	IN
cord-300872-blycbi4u	95	28	to	to	IN
cord-300872-blycbi4u	95	29	its	-PRON-	PRP$
cord-300872-blycbi4u	95	30	promising	promising	JJ
cord-300872-blycbi4u	95	31	antiviral	antiviral	JJ
cord-300872-blycbi4u	95	32	activity	activity	NN
cord-300872-blycbi4u	95	33	;	;	:
cord-300872-blycbi4u	95	34	however	however	RB
cord-300872-blycbi4u	95	35	,	,	,
cord-300872-blycbi4u	95	36	more	more	JJR
cord-300872-blycbi4u	95	37	research	research	NN
cord-300872-blycbi4u	95	38	is	be	VBZ
cord-300872-blycbi4u	95	39	required	require	VBN
cord-300872-blycbi4u	95	40	in	in	IN
cord-300872-blycbi4u	95	41	this	this	DT
cord-300872-blycbi4u	95	42	area	area	NN
cord-300872-blycbi4u	95	43	.	.	.
cord-300872-blycbi4u	95	44	 	 	_SP
cord-300872-blycbi4u	96	1	The	the	DT
cord-300872-blycbi4u	96	2	spread	spread	NN
cord-300872-blycbi4u	96	3	of	of	IN
cord-300872-blycbi4u	96	4	the	the	DT
cord-300872-blycbi4u	96	5	antibiotic	antibiotic	JJ
cord-300872-blycbi4u	96	6	-	-	HYPH
cord-300872-blycbi4u	96	7	resistant	resistant	JJ
cord-300872-blycbi4u	96	8	bacterial	bacterial	JJ
cord-300872-blycbi4u	96	9	strains	strain	NNS
cord-300872-blycbi4u	96	10	constitutes	constitute	VBZ
cord-300872-blycbi4u	96	11	a	a	DT
cord-300872-blycbi4u	96	12	serious	serious	JJ
cord-300872-blycbi4u	96	13	threat	threat	NN
cord-300872-blycbi4u	96	14	to	to	IN
cord-300872-blycbi4u	96	15	public	public	JJ
cord-300872-blycbi4u	96	16	health	health	NN
cord-300872-blycbi4u	96	17	.	.	.
cord-300872-blycbi4u	97	1	Some	some	DT
cord-300872-blycbi4u	97	2	of	of	IN
cord-300872-blycbi4u	97	3	these	these	DT
cord-300872-blycbi4u	97	4	strains	strain	NNS
cord-300872-blycbi4u	97	5	have	have	VBP
cord-300872-blycbi4u	97	6	even	even	RB
cord-300872-blycbi4u	97	7	become	become	VBN
cord-300872-blycbi4u	97	8	resistant	resistant	JJ
cord-300872-blycbi4u	97	9	to	to	IN
cord-300872-blycbi4u	97	10	many	many	JJ
cord-300872-blycbi4u	97	11	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	97	12	and	and	CC
cord-300872-blycbi4u	97	13	chemotherapeutic	chemotherapeutic	JJ
cord-300872-blycbi4u	97	14	agents	agent	NNS
cord-300872-blycbi4u	97	15	;	;	:
cord-300872-blycbi4u	97	16	hence	hence	RB
cord-300872-blycbi4u	97	17	,	,	,
cord-300872-blycbi4u	97	18	the	the	DT
cord-300872-blycbi4u	97	19	term	term	NN
cord-300872-blycbi4u	97	20	"	"	``
cord-300872-blycbi4u	97	21	multidrug	multidrug	NN
cord-300872-blycbi4u	97	22	resistance	resistance	NN
cord-300872-blycbi4u	97	23	"	"	''
cord-300872-blycbi4u	97	24	has	have	VBZ
cord-300872-blycbi4u	97	25	been	be	VBN
cord-300872-blycbi4u	97	26	introduced	introduce	VBN
cord-300872-blycbi4u	97	27	in	in	IN
cord-300872-blycbi4u	97	28	the	the	DT
cord-300872-blycbi4u	97	29	literature	literature	NN
cord-300872-blycbi4u	97	30	.	.	.
cord-300872-blycbi4u	98	1	Thus	thus	RB
cord-300872-blycbi4u	98	2	,	,	,
cord-300872-blycbi4u	98	3	the	the	DT
cord-300872-blycbi4u	98	4	development	development	NN
cord-300872-blycbi4u	98	5	of	of	IN
cord-300872-blycbi4u	98	6	existing	exist	VBG
cord-300872-blycbi4u	98	7	drugs	drug	NNS
cord-300872-blycbi4u	98	8	and	and	CC
cord-300872-blycbi4u	98	9	the	the	DT
cord-300872-blycbi4u	98	10	discovery	discovery	NN
cord-300872-blycbi4u	98	11	of	of	IN
cord-300872-blycbi4u	98	12	new	new	JJ
cord-300872-blycbi4u	98	13	leads	lead	NNS
cord-300872-blycbi4u	98	14	are	be	VBP
cord-300872-blycbi4u	98	15	major	major	JJ
cord-300872-blycbi4u	98	16	strategies	strategy	NNS
cord-300872-blycbi4u	98	17	used	use	VBN
cord-300872-blycbi4u	98	18	to	to	TO
cord-300872-blycbi4u	98	19	combat	combat	VB
cord-300872-blycbi4u	98	20	the	the	DT
cord-300872-blycbi4u	98	21	threat	threat	NN
cord-300872-blycbi4u	98	22	of	of	IN
cord-300872-blycbi4u	98	23	these	these	DT
cord-300872-blycbi4u	98	24	multidrug	multidrug	NN
cord-300872-blycbi4u	98	25	-	-	HYPH
cord-300872-blycbi4u	98	26	resistant	resistant	JJ
cord-300872-blycbi4u	98	27	strains	strain	NNS
cord-300872-blycbi4u	98	28	.	.	.
cord-300872-blycbi4u	99	1	In	in	IN
cord-300872-blycbi4u	99	2	this	this	DT
cord-300872-blycbi4u	99	3	context	context	NN
cord-300872-blycbi4u	99	4	,	,	,
cord-300872-blycbi4u	99	5	Hu	Hu	NNP
cord-300872-blycbi4u	99	6	and	and	CC
cord-300872-blycbi4u	99	7	coworkers	coworker	NNS
cord-300872-blycbi4u	99	8	prepared	prepare	VBD
cord-300872-blycbi4u	99	9	new	new	JJ
cord-300872-blycbi4u	99	10	derivatives	derivative	NNS
cord-300872-blycbi4u	99	11	of	of	IN
cord-300872-blycbi4u	99	12	the	the	DT
cord-300872-blycbi4u	99	13	known	known	JJ
cord-300872-blycbi4u	99	14	potent	potent	JJ
cord-300872-blycbi4u	99	15	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	99	16	agent	agent	NN
cord-300872-blycbi4u	99	17	2,6-difluoro-3-hydroxybenzamide	2,6-difluoro-3-hydroxybenzamide	CD
cord-300872-blycbi4u	99	18	(	(	-LRB-
cord-300872-blycbi4u	99	19	DFMBA	DFMBA	NNP
cord-300872-blycbi4u	99	20	)	)	-RRB-
cord-300872-blycbi4u	99	21	[	[	-LRB-
cord-300872-blycbi4u	99	22	9	9	CD
cord-300872-blycbi4u	99	23	]	]	-RRB-
cord-300872-blycbi4u	99	24	.	.	.
cord-300872-blycbi4u	100	1	The	the	DT
cord-300872-blycbi4u	100	2	substituted	substituted	JJ
cord-300872-blycbi4u	100	3	8-HQ	8-hq	CD
cord-300872-blycbi4u	100	4	8	8	CD
cord-300872-blycbi4u	100	5	was	be	VBD
cord-300872-blycbi4u	100	6	alkylated	alkylate	VBN
cord-300872-blycbi4u	100	7	with	with	IN
cord-300872-blycbi4u	100	8	1,3-dibromopropane	1,3-dibromopropane	CD
cord-300872-blycbi4u	100	9	in	in	IN
cord-300872-blycbi4u	100	10	the	the	DT
cord-300872-blycbi4u	100	11	presence	presence	NN
cord-300872-blycbi4u	100	12	of	of	IN
cord-300872-blycbi4u	100	13	an	an	DT
cord-300872-blycbi4u	100	14	aqueous	aqueous	JJ
cord-300872-blycbi4u	100	15	sodium	sodium	NN
cord-300872-blycbi4u	100	16	hydroxide	hydroxide	NN
cord-300872-blycbi4u	100	17	solution	solution	NN
cord-300872-blycbi4u	100	18	and	and	CC
cord-300872-blycbi4u	100	19	tetrabutylammonium	tetrabutylammonium	NN
cord-300872-blycbi4u	100	20	iodide	iodide	NN
cord-300872-blycbi4u	100	21	(	(	-LRB-
cord-300872-blycbi4u	100	22	TBAI	TBAI	NNP
cord-300872-blycbi4u	100	23	)	)	-RRB-
cord-300872-blycbi4u	100	24	in	in	IN
cord-300872-blycbi4u	100	25	dichloromethane	dichloromethane	NNP
cord-300872-blycbi4u	100	26	to	to	TO
cord-300872-blycbi4u	100	27	afford	afford	VB
cord-300872-blycbi4u	100	28	a	a	DT
cord-300872-blycbi4u	100	29	mono	mono	NN
cord-300872-blycbi4u	100	30	-	-	HYPH
cord-300872-blycbi4u	100	31	halogenated	halogenate	VBN
cord-300872-blycbi4u	100	32	intermediate	intermediate	JJ
cord-300872-blycbi4u	100	33	9	9	CD
cord-300872-blycbi4u	100	34	.	.	.
cord-300872-blycbi4u	101	1	Target	target	NN
cord-300872-blycbi4u	101	2	compound	compound	NNP
cord-300872-blycbi4u	101	3	10	10	CD
cord-300872-blycbi4u	101	4	was	be	VBD
cord-300872-blycbi4u	101	5	obtained	obtain	VBN
cord-300872-blycbi4u	101	6	via	via	IN
cord-300872-blycbi4u	101	7	alkylation	alkylation	NN
cord-300872-blycbi4u	101	8	of	of	IN
cord-300872-blycbi4u	101	9	DFMBA	DFMBA	NNS
cord-300872-blycbi4u	101	10	with	with	IN
cord-300872-blycbi4u	101	11	the	the	DT
cord-300872-blycbi4u	101	12	corresponding	corresponding	JJ
cord-300872-blycbi4u	101	13	8-HQ	8-hq	CD
cord-300872-blycbi4u	101	14	mono	mono	NN
cord-300872-blycbi4u	101	15	bromide	bromide	NN
cord-300872-blycbi4u	101	16	(	(	-LRB-
cord-300872-blycbi4u	101	17	Scheme	scheme	NN
cord-300872-blycbi4u	101	18	3	3	CD
cord-300872-blycbi4u	101	19	)	)	-RRB-
cord-300872-blycbi4u	101	20	.	.	.
cord-300872-blycbi4u	102	1	Molecules	molecule	NNS
cord-300872-blycbi4u	102	2	2020	2020	CD
cord-300872-blycbi4u	102	3	,	,	,
cord-300872-blycbi4u	102	4	25	25	CD
cord-300872-blycbi4u	102	5	,	,	,
cord-300872-blycbi4u	102	6	x	x	NN
cord-300872-blycbi4u	102	7	FOR	for	IN
cord-300872-blycbi4u	102	8	PEER	peer	NN
cord-300872-blycbi4u	102	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	102	10	 	 	_SP
cord-300872-blycbi4u	102	11	4	4	CD
cord-300872-blycbi4u	102	12	of	of	IN
cord-300872-blycbi4u	102	13	26	26	CD
cord-300872-blycbi4u	102	14	hence	hence	RB
cord-300872-blycbi4u	102	15	,	,	,
cord-300872-blycbi4u	102	16	the	the	DT
cord-300872-blycbi4u	102	17	term	term	NN
cord-300872-blycbi4u	102	18	"	"	``
cord-300872-blycbi4u	102	19	multidrug	multidrug	NN
cord-300872-blycbi4u	102	20	resistance	resistance	NN
cord-300872-blycbi4u	102	21	"	"	''
cord-300872-blycbi4u	102	22	has	have	VBZ
cord-300872-blycbi4u	102	23	been	be	VBN
cord-300872-blycbi4u	102	24	introduced	introduce	VBN
cord-300872-blycbi4u	102	25	in	in	IN
cord-300872-blycbi4u	102	26	the	the	DT
cord-300872-blycbi4u	102	27	literature	literature	NN
cord-300872-blycbi4u	102	28	.	.	.
cord-300872-blycbi4u	103	1	Thus	thus	RB
cord-300872-blycbi4u	103	2	,	,	,
cord-300872-blycbi4u	103	3	the	the	DT
cord-300872-blycbi4u	103	4	development	development	NN
cord-300872-blycbi4u	103	5	of	of	IN
cord-300872-blycbi4u	103	6	existing	exist	VBG
cord-300872-blycbi4u	103	7	drugs	drug	NNS
cord-300872-blycbi4u	103	8	and	and	CC
cord-300872-blycbi4u	103	9	the	the	DT
cord-300872-blycbi4u	103	10	discovery	discovery	NN
cord-300872-blycbi4u	103	11	of	of	IN
cord-300872-blycbi4u	103	12	new	new	JJ
cord-300872-blycbi4u	103	13	leads	lead	NNS
cord-300872-blycbi4u	103	14	are	be	VBP
cord-300872-blycbi4u	103	15	major	major	JJ
cord-300872-blycbi4u	103	16	strategies	strategy	NNS
cord-300872-blycbi4u	103	17	used	use	VBN
cord-300872-blycbi4u	103	18	to	to	TO
cord-300872-blycbi4u	103	19	combat	combat	VB
cord-300872-blycbi4u	103	20	the	the	DT
cord-300872-blycbi4u	103	21	threat	threat	NN
cord-300872-blycbi4u	103	22	of	of	IN
cord-300872-blycbi4u	103	23	these	these	DT
cord-300872-blycbi4u	103	24	multidrug	multidrug	NN
cord-300872-blycbi4u	103	25	-	-	HYPH
cord-300872-blycbi4u	103	26	resistant	resistant	JJ
cord-300872-blycbi4u	103	27	strains	strain	NNS
cord-300872-blycbi4u	103	28	.	.	.
cord-300872-blycbi4u	104	1	In	in	IN
cord-300872-blycbi4u	104	2	this	this	DT
cord-300872-blycbi4u	104	3	context	context	NN
cord-300872-blycbi4u	104	4	,	,	,
cord-300872-blycbi4u	104	5	Hu	Hu	NNP
cord-300872-blycbi4u	104	6	and	and	CC
cord-300872-blycbi4u	104	7	coworkers	coworker	NNS
cord-300872-blycbi4u	104	8	prepared	prepare	VBD
cord-300872-blycbi4u	104	9	new	new	JJ
cord-300872-blycbi4u	104	10	derivatives	derivative	NNS
cord-300872-blycbi4u	104	11	of	of	IN
cord-300872-blycbi4u	104	12	the	the	DT
cord-300872-blycbi4u	104	13	known	known	JJ
cord-300872-blycbi4u	104	14	potent	potent	JJ
cord-300872-blycbi4u	104	15	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	104	16	agent	agent	NN
cord-300872-blycbi4u	104	17	2,6-difluoro-3-hydroxybenzamide	2,6-difluoro-3-hydroxybenzamide	CD
cord-300872-blycbi4u	104	18	(	(	-LRB-
cord-300872-blycbi4u	104	19	DFMBA	DFMBA	NNP
cord-300872-blycbi4u	104	20	)	)	-RRB-
cord-300872-blycbi4u	104	21	[	[	-LRB-
cord-300872-blycbi4u	104	22	9	9	CD
cord-300872-blycbi4u	104	23	]	]	-RRB-
cord-300872-blycbi4u	104	24	.	.	.
cord-300872-blycbi4u	105	1	The	the	DT
cord-300872-blycbi4u	105	2	substituted	substituted	JJ
cord-300872-blycbi4u	105	3	8-HQ	8-hq	CD
cord-300872-blycbi4u	105	4	8	8	CD
cord-300872-blycbi4u	105	5	was	be	VBD
cord-300872-blycbi4u	105	6	alkylated	alkylate	VBN
cord-300872-blycbi4u	105	7	with	with	IN
cord-300872-blycbi4u	105	8	1,3-dibromopropane	1,3-dibromopropane	CD
cord-300872-blycbi4u	105	9	in	in	IN
cord-300872-blycbi4u	105	10	the	the	DT
cord-300872-blycbi4u	105	11	presence	presence	NN
cord-300872-blycbi4u	105	12	of	of	IN
cord-300872-blycbi4u	105	13	an	an	DT
cord-300872-blycbi4u	105	14	aqueous	aqueous	JJ
cord-300872-blycbi4u	105	15	sodium	sodium	NN
cord-300872-blycbi4u	105	16	hydroxide	hydroxide	NN
cord-300872-blycbi4u	105	17	solution	solution	NN
cord-300872-blycbi4u	105	18	and	and	CC
cord-300872-blycbi4u	105	19	tetrabutylammonium	tetrabutylammonium	NN
cord-300872-blycbi4u	105	20	iodide	iodide	NN
cord-300872-blycbi4u	105	21	(	(	-LRB-
cord-300872-blycbi4u	105	22	TBAI	TBAI	NNP
cord-300872-blycbi4u	105	23	)	)	-RRB-
cord-300872-blycbi4u	105	24	in	in	IN
cord-300872-blycbi4u	105	25	dichloromethane	dichloromethane	NNP
cord-300872-blycbi4u	105	26	to	to	TO
cord-300872-blycbi4u	105	27	afford	afford	VB
cord-300872-blycbi4u	105	28	a	a	DT
cord-300872-blycbi4u	105	29	mono	mono	NN
cord-300872-blycbi4u	105	30	-	-	HYPH
cord-300872-blycbi4u	105	31	halogenated	halogenate	VBN
cord-300872-blycbi4u	105	32	intermediate	intermediate	JJ
cord-300872-blycbi4u	105	33	9	9	CD
cord-300872-blycbi4u	105	34	.	.	.
cord-300872-blycbi4u	106	1	Target	target	NN
cord-300872-blycbi4u	106	2	compound	compound	NNP
cord-300872-blycbi4u	106	3	10	10	CD
cord-300872-blycbi4u	106	4	was	be	VBD
cord-300872-blycbi4u	106	5	obtained	obtain	VBN
cord-300872-blycbi4u	106	6	via	via	IN
cord-300872-blycbi4u	106	7	alkylation	alkylation	NN
cord-300872-blycbi4u	106	8	of	of	IN
cord-300872-blycbi4u	106	9	DFMBA	DFMBA	NNS
cord-300872-blycbi4u	106	10	with	with	IN
cord-300872-blycbi4u	106	11	the	the	DT
cord-300872-blycbi4u	106	12	corresponding	corresponding	JJ
cord-300872-blycbi4u	106	13	8-HQ	8-hq	CD
cord-300872-blycbi4u	106	14	mono	mono	NN
cord-300872-blycbi4u	106	15	bromide	bromide	NN
cord-300872-blycbi4u	106	16	(	(	-LRB-
cord-300872-blycbi4u	106	17	Scheme	scheme	NN
cord-300872-blycbi4u	106	18	3	3	CD
cord-300872-blycbi4u	106	19	)	)	-RRB-
cord-300872-blycbi4u	106	20	.	.	.
cord-300872-blycbi4u	107	1	Scheme	scheme	NN
cord-300872-blycbi4u	107	2	3	3	CD
cord-300872-blycbi4u	107	3	.	.	.
cord-300872-blycbi4u	108	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	108	2	of	of	IN
cord-300872-blycbi4u	108	3	2,6-difluoro-3-hydroxybenzamide-8-hydroxyquinoline	2,6-difluoro-3-hydroxybenzamide-8-hydroxyquinoline	CD
cord-300872-blycbi4u	108	4	derivatives	derivative	NNS
cord-300872-blycbi4u	108	5	.	.	.
cord-300872-blycbi4u	109	1	The	the	DT
cord-300872-blycbi4u	109	2	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	109	3	activity	activity	NN
cord-300872-blycbi4u	109	4	of	of	IN
cord-300872-blycbi4u	109	5	these	these	DT
cord-300872-blycbi4u	109	6	derivatives	derivative	NNS
cord-300872-blycbi4u	109	7	was	be	VBD
cord-300872-blycbi4u	109	8	evaluated	evaluate	VBN
cord-300872-blycbi4u	109	9	against	against	IN
cord-300872-blycbi4u	109	10	several	several	JJ
cord-300872-blycbi4u	109	11	Gram	gram	NN
cord-300872-blycbi4u	109	12	-	-	HYPH
cord-300872-blycbi4u	109	13	positive	positive	JJ
cord-300872-blycbi4u	109	14	and	and	CC
cord-300872-blycbi4u	109	15	Gram	gram	NN
cord-300872-blycbi4u	109	16	-	-	HYPH
cord-300872-blycbi4u	109	17	negative	negative	JJ
cord-300872-blycbi4u	109	18	bacteria	bacteria	NNS
cord-300872-blycbi4u	109	19	using	use	VBG
cord-300872-blycbi4u	109	20	the	the	DT
cord-300872-blycbi4u	109	21	zone	zone	NN
cord-300872-blycbi4u	109	22	-	-	HYPH
cord-300872-blycbi4u	109	23	of	of	IN
cord-300872-blycbi4u	109	24	-	-	HYPH
cord-300872-blycbi4u	109	25	inhibition	inhibition	NN
cord-300872-blycbi4u	109	26	test	test	NN
cord-300872-blycbi4u	109	27	.	.	.
cord-300872-blycbi4u	110	1	Inhibition	inhibition	NN
cord-300872-blycbi4u	110	2	zones	zone	NNS
cord-300872-blycbi4u	110	3	were	be	VBD
cord-300872-blycbi4u	110	4	compared	compare	VBN
cord-300872-blycbi4u	110	5	to	to	IN
cord-300872-blycbi4u	110	6	the	the	DT
cord-300872-blycbi4u	110	7	standard	standard	JJ
cord-300872-blycbi4u	110	8	antibiotic	antibiotic	NN
cord-300872-blycbi4u	110	9	PC190723	PC190723	NNP
cord-300872-blycbi4u	110	10	(	(	-LRB-
cord-300872-blycbi4u	110	11	11	11	CD
cord-300872-blycbi4u	110	12	)	)	-RRB-
cord-300872-blycbi4u	110	13	,	,	,
cord-300872-blycbi4u	110	14	which	which	WDT
cord-300872-blycbi4u	110	15	is	be	VBZ
cord-300872-blycbi4u	110	16	an	an	DT
cord-300872-blycbi4u	110	17	effective	effective	JJ
cord-300872-blycbi4u	110	18	bactericidal	bactericidal	JJ
cord-300872-blycbi4u	110	19	cell	cell	NN
cord-300872-blycbi4u	110	20	division	division	NN
cord-300872-blycbi4u	110	21	inhibitor	inhibitor	NN
cord-300872-blycbi4u	110	22	that	that	WDT
cord-300872-blycbi4u	110	23	targets	target	VBZ
cord-300872-blycbi4u	110	24	cell	cell	NN
cord-300872-blycbi4u	110	25	division	division	NN
cord-300872-blycbi4u	110	26	protein	protein	NN
cord-300872-blycbi4u	110	27	(	(	-LRB-
cord-300872-blycbi4u	110	28	FtsZ	FtsZ	NNP
cord-300872-blycbi4u	110	29	)	)	-RRB-
cord-300872-blycbi4u	110	30	in	in	IN
cord-300872-blycbi4u	110	31	several	several	JJ
cord-300872-blycbi4u	110	32	Gram	gram	NN
cord-300872-blycbi4u	110	33	-	-	HYPH
cord-300872-blycbi4u	110	34	positive	positive	JJ
cord-300872-blycbi4u	110	35	bacteria	bacteria	NNS
cord-300872-blycbi4u	110	36	.	.	.
cord-300872-blycbi4u	111	1	The	the	DT
cord-300872-blycbi4u	111	2	results	result	NNS
cord-300872-blycbi4u	111	3	showed	show	VBD
cord-300872-blycbi4u	111	4	that	that	IN
cord-300872-blycbi4u	111	5	the	the	DT
cord-300872-blycbi4u	111	6	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	111	7	activities	activity	NNS
cord-300872-blycbi4u	111	8	were	be	VBD
cord-300872-blycbi4u	111	9	lower	low	JJR
cord-300872-blycbi4u	111	10	than	than	IN
cord-300872-blycbi4u	111	11	that	that	DT
cord-300872-blycbi4u	111	12	of	of	IN
cord-300872-blycbi4u	111	13	PC190723	pc190723	NN
cord-300872-blycbi4u	111	14	.	.	.
cord-300872-blycbi4u	112	1	In	in	IN
cord-300872-blycbi4u	112	2	addition	addition	NN
cord-300872-blycbi4u	112	3	,	,	,
cord-300872-blycbi4u	112	4	the	the	DT
cord-300872-blycbi4u	112	5	highest	high	JJS
cord-300872-blycbi4u	112	6	inhibition	inhibition	NN
cord-300872-blycbi4u	112	7	zone	zone	NN
cord-300872-blycbi4u	112	8	ratios	ratio	NNS
cord-300872-blycbi4u	112	9	(	(	-LRB-
cord-300872-blycbi4u	112	10	inhibition	inhibition	NN
cord-300872-blycbi4u	112	11	zone	zone	NN
cord-300872-blycbi4u	112	12	of	of	IN
cord-300872-blycbi4u	112	13	the	the	DT
cord-300872-blycbi4u	112	14	test	test	NN
cord-300872-blycbi4u	112	15	compound	compound	NN
cord-300872-blycbi4u	112	16	/	/	SYM
cord-300872-blycbi4u	112	17	inhibition	inhibition	NN
cord-300872-blycbi4u	112	18	zone	zone	NN
cord-300872-blycbi4u	112	19	of	of	IN
cord-300872-blycbi4u	112	20	the	the	DT
cord-300872-blycbi4u	112	21	standard	standard	NN
cord-300872-blycbi4u	112	22	)	)	-RRB-
cord-300872-blycbi4u	112	23	of	of	IN
cord-300872-blycbi4u	112	24	0.25	0.25	CD
cord-300872-blycbi4u	112	25	and	and	CC
cord-300872-blycbi4u	112	26	0.18	0.18	CD
cord-300872-blycbi4u	112	27	against	against	IN
cord-300872-blycbi4u	112	28	S.	S.	NNP
cord-300872-blycbi4u	112	29	aureus	aureu	NNS
cord-300872-blycbi4u	112	30	were	be	VBD
cord-300872-blycbi4u	112	31	observed	observe	VBN
cord-300872-blycbi4u	112	32	for	for	IN
cord-300872-blycbi4u	112	33	derivatives	derivative	NNS
cord-300872-blycbi4u	112	34	where	where	WRB
cord-300872-blycbi4u	112	35	R	r	NN
cord-300872-blycbi4u	112	36	=	=	SYM
cord-300872-blycbi4u	112	37	5-Cl	5-cl	NN
cord-300872-blycbi4u	112	38	and	and	CC
cord-300872-blycbi4u	112	39	5,7-diCl	5,7-dicl	CD
cord-300872-blycbi4u	112	40	,	,	,
cord-300872-blycbi4u	112	41	respectively	respectively	RB
cord-300872-blycbi4u	112	42	.	.	.
cord-300872-blycbi4u	113	1	Moreover	moreover	RB
cord-300872-blycbi4u	113	2	,	,	,
cord-300872-blycbi4u	113	3	when	when	WRB
cord-300872-blycbi4u	113	4	comparing	compare	VBG
cord-300872-blycbi4u	113	5	the	the	DT
cord-300872-blycbi4u	113	6	activity	activity	NN
cord-300872-blycbi4u	113	7	of	of	IN
cord-300872-blycbi4u	113	8	8-HQ	8-hq	CD
cord-300872-blycbi4u	113	9	derivatives	derivative	NNS
cord-300872-blycbi4u	113	10	with	with	IN
cord-300872-blycbi4u	113	11	8-HQ	8-hq	CD
cord-300872-blycbi4u	113	12	naphthalene	naphthalene	NN
cord-300872-blycbi4u	113	13	analogues	analogue	NNS
cord-300872-blycbi4u	113	14	,	,	,
cord-300872-blycbi4u	113	15	the	the	DT
cord-300872-blycbi4u	113	16	former	former	JJ
cord-300872-blycbi4u	113	17	were	be	VBD
cord-300872-blycbi4u	113	18	more	more	RBR
cord-300872-blycbi4u	113	19	active	active	JJ
cord-300872-blycbi4u	113	20	;	;	:
cord-300872-blycbi4u	113	21	this	this	DT
cord-300872-blycbi4u	113	22	is	be	VBZ
cord-300872-blycbi4u	113	23	probably	probably	RB
cord-300872-blycbi4u	113	24	due	due	JJ
cord-300872-blycbi4u	113	25	to	to	IN
cord-300872-blycbi4u	113	26	the	the	DT
cord-300872-blycbi4u	113	27	ring	ring	NN
cord-300872-blycbi4u	113	28	nitrogen	nitrogen	NN
cord-300872-blycbi4u	113	29	,	,	,
cord-300872-blycbi4u	113	30	which	which	WDT
cord-300872-blycbi4u	113	31	may	may	MD
cord-300872-blycbi4u	113	32	increase	increase	VB
cord-300872-blycbi4u	113	33	the	the	DT
cord-300872-blycbi4u	113	34	polarity	polarity	NN
cord-300872-blycbi4u	113	35	and	and	CC
cord-300872-blycbi4u	113	36	water	water	NN
cord-300872-blycbi4u	113	37	solubility	solubility	NN
cord-300872-blycbi4u	113	38	of	of	IN
cord-300872-blycbi4u	113	39	the	the	DT
cord-300872-blycbi4u	113	40	compounds	compound	NNS
cord-300872-blycbi4u	113	41	-	-	,
cord-300872-blycbi4u	113	42	factors	factor	NNS
cord-300872-blycbi4u	113	43	that	that	WDT
cord-300872-blycbi4u	113	44	are	be	VBP
cord-300872-blycbi4u	113	45	required	require	VBN
cord-300872-blycbi4u	113	46	for	for	IN
cord-300872-blycbi4u	113	47	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	113	48	activity	activity	NN
cord-300872-blycbi4u	113	49	.	.	.
cord-300872-blycbi4u	114	1	Krishna	Krishna	NNP
cord-300872-blycbi4u	114	2	reported	report	VBD
cord-300872-blycbi4u	114	3	the	the	DT
cord-300872-blycbi4u	114	4	synthesis	synthesis	NN
cord-300872-blycbi4u	114	5	of	of	IN
cord-300872-blycbi4u	114	6	a	a	DT
cord-300872-blycbi4u	114	7	series	series	NN
cord-300872-blycbi4u	114	8	of	of	IN
cord-300872-blycbi4u	114	9	new	new	JJ
cord-300872-blycbi4u	114	10	5-amino-7-bromoquinolin-8-yl	5-amino-7-bromoquinolin-8-yl	CD
cord-300872-blycbi4u	114	11	sulfonates	sulfonate	NNS
cord-300872-blycbi4u	114	12	15	15	CD
cord-300872-blycbi4u	114	13	in	in	IN
cord-300872-blycbi4u	114	14	good	good	JJ
cord-300872-blycbi4u	114	15	yield	yield	NN
cord-300872-blycbi4u	114	16	using	use	VBG
cord-300872-blycbi4u	114	17	a	a	DT
cord-300872-blycbi4u	114	18	multistep	multistep	JJ
cord-300872-blycbi4u	114	19	synthesis	synthesis	NN
cord-300872-blycbi4u	114	20	method	method	NN
cord-300872-blycbi4u	114	21	[	[	-LRB-
cord-300872-blycbi4u	114	22	10	10	CD
cord-300872-blycbi4u	114	23	]	]	-RRB-
cord-300872-blycbi4u	114	24	.	.	.
cord-300872-blycbi4u	115	1	Bromination	Bromination	NNP
cord-300872-blycbi4u	115	2	of	of	IN
cord-300872-blycbi4u	115	3	8-hydroxquinoline	8-hydroxquinoline	CD
cord-300872-blycbi4u	115	4	1	1	CD
cord-300872-blycbi4u	115	5	with	with	IN
cord-300872-blycbi4u	115	6	Nbromosuccinimide	Nbromosuccinimide	NNP
cord-300872-blycbi4u	115	7	(	(	-LRB-
cord-300872-blycbi4u	115	8	NBS	NBS	NNP
cord-300872-blycbi4u	115	9	)	)	-RRB-
cord-300872-blycbi4u	115	10	in	in	IN
cord-300872-blycbi4u	115	11	chloroform	chloroform	NN
cord-300872-blycbi4u	115	12	afforded	afford	VBD
cord-300872-blycbi4u	115	13	7-bromoquinolin-8-ol	7-bromoquinolin-8-ol	CD
cord-300872-blycbi4u	115	14	,	,	,
cord-300872-blycbi4u	115	15	which	which	WDT
cord-300872-blycbi4u	115	16	upon	upon	IN
cord-300872-blycbi4u	115	17	treatment	treatment	NN
cord-300872-blycbi4u	115	18	with	with	IN
cord-300872-blycbi4u	115	19	NaNO2	NaNO2	NNP
cord-300872-blycbi4u	115	20	/	/	SYM
cord-300872-blycbi4u	115	21	HCl	HCl	NNP
cord-300872-blycbi4u	115	22	followed	follow	VBD
cord-300872-blycbi4u	115	23	by	by	IN
cord-300872-blycbi4u	115	24	reduction	reduction	NN
cord-300872-blycbi4u	115	25	with	with	IN
cord-300872-blycbi4u	115	26	Na2S2O4	Na2S2O4	NNP
cord-300872-blycbi4u	115	27	in	in	IN
cord-300872-blycbi4u	115	28	1:1	1:1	CD
cord-300872-blycbi4u	115	29	tetrahydrofuran	tetrahydrofuran	NN
cord-300872-blycbi4u	115	30	(	(	-LRB-
cord-300872-blycbi4u	115	31	THF	THF	NNP
cord-300872-blycbi4u	115	32	)	)	-RRB-
cord-300872-blycbi4u	115	33	and	and	CC
cord-300872-blycbi4u	115	34	water	water	NN
cord-300872-blycbi4u	115	35	gave	give	VBD
cord-300872-blycbi4u	115	36	5amino-7-bromoquinolin-8-ol	5amino-7-bromoquinolin-8-ol	CD
cord-300872-blycbi4u	115	37	14	14	CD
cord-300872-blycbi4u	115	38	.	.	.
cord-300872-blycbi4u	116	1	The	the	DT
cord-300872-blycbi4u	116	2	target	target	NN
cord-300872-blycbi4u	116	3	sulfonate	sulfonate	NN
cord-300872-blycbi4u	116	4	derivatives	derivative	NNS
cord-300872-blycbi4u	116	5	15	15	CD
cord-300872-blycbi4u	116	6	were	be	VBD
cord-300872-blycbi4u	116	7	obtained	obtain	VBN
cord-300872-blycbi4u	116	8	from	from	IN
cord-300872-blycbi4u	116	9	5-amino-7bromoquinolin-8-ol	5-amino-7bromoquinolin-8-ol	NN
cord-300872-blycbi4u	116	10	by	by	IN
cord-300872-blycbi4u	116	11	reaction	reaction	NN
cord-300872-blycbi4u	116	12	with	with	IN
cord-300872-blycbi4u	116	13	various	various	JJ
cord-300872-blycbi4u	116	14	sulfonyl	sulfonyl	NN
cord-300872-blycbi4u	116	15	chlorides	chloride	NNS
cord-300872-blycbi4u	116	16	in	in	IN
cord-300872-blycbi4u	116	17	dry	dry	JJ
cord-300872-blycbi4u	116	18	THF	thf	NN
cord-300872-blycbi4u	116	19	in	in	IN
cord-300872-blycbi4u	116	20	the	the	DT
cord-300872-blycbi4u	116	21	presence	presence	NN
cord-300872-blycbi4u	116	22	of	of	IN
cord-300872-blycbi4u	116	23	triethylamine	triethylamine	NN
cord-300872-blycbi4u	116	24	(	(	-LRB-
cord-300872-blycbi4u	116	25	TEA	tea	NN
cord-300872-blycbi4u	116	26	)	)	-RRB-
cord-300872-blycbi4u	117	1	(	(	-LRB-
cord-300872-blycbi4u	117	2	Scheme	scheme	NN
cord-300872-blycbi4u	117	3	4	4	CD
cord-300872-blycbi4u	117	4	)	)	-RRB-
cord-300872-blycbi4u	117	5	.	.	.
cord-300872-blycbi4u	118	1	The	the	DT
cord-300872-blycbi4u	118	2	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	118	3	activity	activity	NN
cord-300872-blycbi4u	118	4	of	of	IN
cord-300872-blycbi4u	118	5	these	these	DT
cord-300872-blycbi4u	118	6	derivatives	derivative	NNS
cord-300872-blycbi4u	118	7	was	be	VBD
cord-300872-blycbi4u	118	8	evaluated	evaluate	VBN
cord-300872-blycbi4u	118	9	against	against	IN
cord-300872-blycbi4u	118	10	several	several	JJ
cord-300872-blycbi4u	118	11	Gram	gram	NN
cord-300872-blycbi4u	118	12	-	-	HYPH
cord-300872-blycbi4u	118	13	positive	positive	JJ
cord-300872-blycbi4u	118	14	and	and	CC
cord-300872-blycbi4u	118	15	Gram	gram	NN
cord-300872-blycbi4u	118	16	-	-	HYPH
cord-300872-blycbi4u	118	17	negative	negative	JJ
cord-300872-blycbi4u	118	18	bacteria	bacteria	NNS
cord-300872-blycbi4u	118	19	using	use	VBG
cord-300872-blycbi4u	118	20	the	the	DT
cord-300872-blycbi4u	118	21	zone	zone	NN
cord-300872-blycbi4u	118	22	-	-	HYPH
cord-300872-blycbi4u	118	23	of	of	IN
cord-300872-blycbi4u	118	24	-	-	HYPH
cord-300872-blycbi4u	118	25	inhibition	inhibition	NN
cord-300872-blycbi4u	118	26	test	test	NN
cord-300872-blycbi4u	118	27	.	.	.
cord-300872-blycbi4u	119	1	Inhibition	inhibition	NN
cord-300872-blycbi4u	119	2	zones	zone	NNS
cord-300872-blycbi4u	119	3	were	be	VBD
cord-300872-blycbi4u	119	4	compared	compare	VBN
cord-300872-blycbi4u	119	5	to	to	IN
cord-300872-blycbi4u	119	6	the	the	DT
cord-300872-blycbi4u	119	7	standard	standard	JJ
cord-300872-blycbi4u	119	8	antibiotic	antibiotic	NN
cord-300872-blycbi4u	119	9	PC190723	PC190723	NNP
cord-300872-blycbi4u	119	10	(	(	-LRB-
cord-300872-blycbi4u	119	11	11	11	CD
cord-300872-blycbi4u	119	12	)	)	-RRB-
cord-300872-blycbi4u	119	13	,	,	,
cord-300872-blycbi4u	119	14	which	which	WDT
cord-300872-blycbi4u	119	15	is	be	VBZ
cord-300872-blycbi4u	119	16	an	an	DT
cord-300872-blycbi4u	119	17	effective	effective	JJ
cord-300872-blycbi4u	119	18	bactericidal	bactericidal	JJ
cord-300872-blycbi4u	119	19	cell	cell	NN
cord-300872-blycbi4u	119	20	division	division	NN
cord-300872-blycbi4u	119	21	inhibitor	inhibitor	NN
cord-300872-blycbi4u	119	22	that	that	WDT
cord-300872-blycbi4u	119	23	targets	target	VBZ
cord-300872-blycbi4u	119	24	cell	cell	NN
cord-300872-blycbi4u	119	25	division	division	NN
cord-300872-blycbi4u	119	26	protein	protein	NN
cord-300872-blycbi4u	119	27	(	(	-LRB-
cord-300872-blycbi4u	119	28	FtsZ	FtsZ	NNP
cord-300872-blycbi4u	119	29	)	)	-RRB-
cord-300872-blycbi4u	119	30	in	in	IN
cord-300872-blycbi4u	119	31	several	several	JJ
cord-300872-blycbi4u	119	32	Gram	gram	NN
cord-300872-blycbi4u	119	33	-	-	HYPH
cord-300872-blycbi4u	119	34	positive	positive	JJ
cord-300872-blycbi4u	119	35	bacteria	bacteria	NNS
cord-300872-blycbi4u	119	36	.	.	.
cord-300872-blycbi4u	120	1	The	the	DT
cord-300872-blycbi4u	120	2	results	result	NNS
cord-300872-blycbi4u	120	3	showed	show	VBD
cord-300872-blycbi4u	120	4	that	that	IN
cord-300872-blycbi4u	120	5	the	the	DT
cord-300872-blycbi4u	120	6	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	120	7	activities	activity	NNS
cord-300872-blycbi4u	120	8	were	be	VBD
cord-300872-blycbi4u	120	9	lower	low	JJR
cord-300872-blycbi4u	120	10	than	than	IN
cord-300872-blycbi4u	120	11	that	that	DT
cord-300872-blycbi4u	120	12	of	of	IN
cord-300872-blycbi4u	120	13	PC190723	pc190723	NN
cord-300872-blycbi4u	120	14	.	.	.
cord-300872-blycbi4u	121	1	In	in	IN
cord-300872-blycbi4u	121	2	addition	addition	NN
cord-300872-blycbi4u	121	3	,	,	,
cord-300872-blycbi4u	121	4	the	the	DT
cord-300872-blycbi4u	121	5	highest	high	JJS
cord-300872-blycbi4u	121	6	inhibition	inhibition	NN
cord-300872-blycbi4u	121	7	zone	zone	NN
cord-300872-blycbi4u	121	8	ratios	ratio	NNS
cord-300872-blycbi4u	121	9	(	(	-LRB-
cord-300872-blycbi4u	121	10	inhibition	inhibition	NN
cord-300872-blycbi4u	121	11	zone	zone	NN
cord-300872-blycbi4u	121	12	of	of	IN
cord-300872-blycbi4u	121	13	the	the	DT
cord-300872-blycbi4u	121	14	test	test	NN
cord-300872-blycbi4u	121	15	compound	compound	NN
cord-300872-blycbi4u	121	16	/	/	SYM
cord-300872-blycbi4u	121	17	inhibition	inhibition	NN
cord-300872-blycbi4u	121	18	zone	zone	NN
cord-300872-blycbi4u	121	19	of	of	IN
cord-300872-blycbi4u	121	20	the	the	DT
cord-300872-blycbi4u	121	21	standard	standard	NN
cord-300872-blycbi4u	121	22	)	)	-RRB-
cord-300872-blycbi4u	121	23	of	of	IN
cord-300872-blycbi4u	121	24	0.25	0.25	CD
cord-300872-blycbi4u	121	25	and	and	CC
cord-300872-blycbi4u	121	26	0.18	0.18	CD
cord-300872-blycbi4u	121	27	against	against	IN
cord-300872-blycbi4u	121	28	S.	S.	NNP
cord-300872-blycbi4u	121	29	aureus	aureu	NNS
cord-300872-blycbi4u	121	30	were	be	VBD
cord-300872-blycbi4u	121	31	observed	observe	VBN
cord-300872-blycbi4u	121	32	for	for	IN
cord-300872-blycbi4u	121	33	derivatives	derivative	NNS
cord-300872-blycbi4u	121	34	where	where	WRB
cord-300872-blycbi4u	121	35	R	r	NN
cord-300872-blycbi4u	121	36	=	=	SYM
cord-300872-blycbi4u	121	37	5-Cl	5-cl	NN
cord-300872-blycbi4u	121	38	and	and	CC
cord-300872-blycbi4u	121	39	5,7-diCl	5,7-dicl	CD
cord-300872-blycbi4u	121	40	,	,	,
cord-300872-blycbi4u	121	41	respectively	respectively	RB
cord-300872-blycbi4u	121	42	.	.	.
cord-300872-blycbi4u	122	1	Moreover	moreover	RB
cord-300872-blycbi4u	122	2	,	,	,
cord-300872-blycbi4u	122	3	when	when	WRB
cord-300872-blycbi4u	122	4	comparing	compare	VBG
cord-300872-blycbi4u	122	5	the	the	DT
cord-300872-blycbi4u	122	6	activity	activity	NN
cord-300872-blycbi4u	122	7	of	of	IN
cord-300872-blycbi4u	122	8	8-HQ	8-hq	CD
cord-300872-blycbi4u	122	9	derivatives	derivative	NNS
cord-300872-blycbi4u	122	10	with	with	IN
cord-300872-blycbi4u	122	11	8-HQ	8-hq	CD
cord-300872-blycbi4u	122	12	naphthalene	naphthalene	NN
cord-300872-blycbi4u	122	13	analogues	analogue	NNS
cord-300872-blycbi4u	122	14	,	,	,
cord-300872-blycbi4u	122	15	the	the	DT
cord-300872-blycbi4u	122	16	former	former	JJ
cord-300872-blycbi4u	122	17	were	be	VBD
cord-300872-blycbi4u	122	18	more	more	RBR
cord-300872-blycbi4u	122	19	active	active	JJ
cord-300872-blycbi4u	122	20	;	;	:
cord-300872-blycbi4u	122	21	this	this	DT
cord-300872-blycbi4u	122	22	is	be	VBZ
cord-300872-blycbi4u	122	23	probably	probably	RB
cord-300872-blycbi4u	122	24	due	due	JJ
cord-300872-blycbi4u	122	25	to	to	IN
cord-300872-blycbi4u	122	26	the	the	DT
cord-300872-blycbi4u	122	27	ring	ring	NN
cord-300872-blycbi4u	122	28	nitrogen	nitrogen	NN
cord-300872-blycbi4u	122	29	,	,	,
cord-300872-blycbi4u	122	30	which	which	WDT
cord-300872-blycbi4u	122	31	may	may	MD
cord-300872-blycbi4u	122	32	increase	increase	VB
cord-300872-blycbi4u	122	33	the	the	DT
cord-300872-blycbi4u	122	34	polarity	polarity	NN
cord-300872-blycbi4u	122	35	and	and	CC
cord-300872-blycbi4u	122	36	water	water	NN
cord-300872-blycbi4u	122	37	solubility	solubility	NN
cord-300872-blycbi4u	122	38	of	of	IN
cord-300872-blycbi4u	122	39	the	the	DT
cord-300872-blycbi4u	122	40	compounds	compound	NNS
cord-300872-blycbi4u	122	41	-	-	,
cord-300872-blycbi4u	122	42	factors	factor	NNS
cord-300872-blycbi4u	122	43	that	that	WDT
cord-300872-blycbi4u	122	44	are	be	VBP
cord-300872-blycbi4u	122	45	required	require	VBN
cord-300872-blycbi4u	122	46	for	for	IN
cord-300872-blycbi4u	122	47	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	122	48	activity	activity	NN
cord-300872-blycbi4u	122	49	.	.	.
cord-300872-blycbi4u	123	1	Krishna	Krishna	NNP
cord-300872-blycbi4u	123	2	reported	report	VBD
cord-300872-blycbi4u	123	3	the	the	DT
cord-300872-blycbi4u	123	4	synthesis	synthesis	NN
cord-300872-blycbi4u	123	5	of	of	IN
cord-300872-blycbi4u	123	6	a	a	DT
cord-300872-blycbi4u	123	7	series	series	NN
cord-300872-blycbi4u	123	8	of	of	IN
cord-300872-blycbi4u	123	9	new	new	JJ
cord-300872-blycbi4u	123	10	5-amino-7-bromoquinolin-8-yl	5-amino-7-bromoquinolin-8-yl	CD
cord-300872-blycbi4u	123	11	sulfonates	sulfonate	NNS
cord-300872-blycbi4u	123	12	15	15	CD
cord-300872-blycbi4u	123	13	in	in	IN
cord-300872-blycbi4u	123	14	good	good	JJ
cord-300872-blycbi4u	123	15	yield	yield	NN
cord-300872-blycbi4u	123	16	using	use	VBG
cord-300872-blycbi4u	123	17	a	a	DT
cord-300872-blycbi4u	123	18	multistep	multistep	JJ
cord-300872-blycbi4u	123	19	synthesis	synthesis	NN
cord-300872-blycbi4u	123	20	method	method	NN
cord-300872-blycbi4u	123	21	[	[	-LRB-
cord-300872-blycbi4u	123	22	10	10	CD
cord-300872-blycbi4u	123	23	]	]	-RRB-
cord-300872-blycbi4u	123	24	.	.	.
cord-300872-blycbi4u	124	1	Bromination	Bromination	NNP
cord-300872-blycbi4u	124	2	of	of	IN
cord-300872-blycbi4u	124	3	8-hydroxquinoline	8-hydroxquinoline	CD
cord-300872-blycbi4u	124	4	1	1	CD
cord-300872-blycbi4u	124	5	with	with	IN
cord-300872-blycbi4u	124	6	N	n	CD
cord-300872-blycbi4u	124	7	-	-	HYPH
cord-300872-blycbi4u	124	8	bromosuccinimide	bromosuccinimide	NN
cord-300872-blycbi4u	124	9	(	(	-LRB-
cord-300872-blycbi4u	124	10	NBS	NBS	NNP
cord-300872-blycbi4u	124	11	)	)	-RRB-
cord-300872-blycbi4u	124	12	in	in	IN
cord-300872-blycbi4u	124	13	chloroform	chloroform	NN
cord-300872-blycbi4u	124	14	afforded	afford	VBD
cord-300872-blycbi4u	124	15	7-bromoquinolin-8-ol	7-bromoquinolin-8-ol	CD
cord-300872-blycbi4u	124	16	,	,	,
cord-300872-blycbi4u	124	17	which	which	WDT
cord-300872-blycbi4u	124	18	upon	upon	IN
cord-300872-blycbi4u	124	19	treatment	treatment	NN
cord-300872-blycbi4u	124	20	with	with	IN
cord-300872-blycbi4u	124	21	NaNO	NaNO	NNP
cord-300872-blycbi4u	124	22	2	2	CD
cord-300872-blycbi4u	124	23	/HCl	/HCl	,
cord-300872-blycbi4u	124	24	followed	follow	VBN
cord-300872-blycbi4u	124	25	by	by	IN
cord-300872-blycbi4u	124	26	reduction	reduction	NN
cord-300872-blycbi4u	124	27	with	with	IN
cord-300872-blycbi4u	124	28	Na	Na	NNP
cord-300872-blycbi4u	124	29	2	2	CD
cord-300872-blycbi4u	124	30	S	s	NN
cord-300872-blycbi4u	124	31	2	2	CD
cord-300872-blycbi4u	124	32	O	o	CD
cord-300872-blycbi4u	124	33	4	4	CD
cord-300872-blycbi4u	124	34	in	in	IN
cord-300872-blycbi4u	124	35	1:1	1:1	CD
cord-300872-blycbi4u	124	36	tetrahydrofuran	tetrahydrofuran	NN
cord-300872-blycbi4u	124	37	(	(	-LRB-
cord-300872-blycbi4u	124	38	THF	THF	NNP
cord-300872-blycbi4u	124	39	)	)	-RRB-
cord-300872-blycbi4u	124	40	and	and	CC
cord-300872-blycbi4u	124	41	water	water	NN
cord-300872-blycbi4u	124	42	gave	give	VBD
cord-300872-blycbi4u	124	43	5-amino-7-bromoquinolin-8-ol	5-amino-7-bromoquinolin-8-ol	CD
cord-300872-blycbi4u	124	44	14	14	CD
cord-300872-blycbi4u	124	45	.	.	.
cord-300872-blycbi4u	125	1	The	the	DT
cord-300872-blycbi4u	125	2	target	target	NN
cord-300872-blycbi4u	125	3	sulfonate	sulfonate	NN
cord-300872-blycbi4u	125	4	derivatives	derivative	NNS
cord-300872-blycbi4u	125	5	15	15	CD
cord-300872-blycbi4u	125	6	were	be	VBD
cord-300872-blycbi4u	125	7	obtained	obtain	VBN
cord-300872-blycbi4u	125	8	from	from	IN
cord-300872-blycbi4u	125	9	5-amino-7-bromoquinolin-8-ol	5-amino-7-bromoquinolin-8-ol	CD
cord-300872-blycbi4u	125	10	by	by	IN
cord-300872-blycbi4u	125	11	reaction	reaction	NN
cord-300872-blycbi4u	125	12	with	with	IN
cord-300872-blycbi4u	125	13	various	various	JJ
cord-300872-blycbi4u	125	14	sulfonyl	sulfonyl	NN
cord-300872-blycbi4u	125	15	chlorides	chloride	NNS
cord-300872-blycbi4u	125	16	in	in	IN
cord-300872-blycbi4u	125	17	dry	dry	JJ
cord-300872-blycbi4u	125	18	THF	thf	NN
cord-300872-blycbi4u	125	19	in	in	IN
cord-300872-blycbi4u	125	20	the	the	DT
cord-300872-blycbi4u	125	21	presence	presence	NN
cord-300872-blycbi4u	125	22	of	of	IN
cord-300872-blycbi4u	125	23	triethylamine	triethylamine	NN
cord-300872-blycbi4u	125	24	(	(	-LRB-
cord-300872-blycbi4u	125	25	TEA	tea	NN
cord-300872-blycbi4u	125	26	)	)	-RRB-
cord-300872-blycbi4u	126	1	(	(	-LRB-
cord-300872-blycbi4u	126	2	Scheme	scheme	NN
cord-300872-blycbi4u	126	3	4	4	CD
cord-300872-blycbi4u	126	4	)	)	-RRB-
cord-300872-blycbi4u	126	5	.	.	.
cord-300872-blycbi4u	127	1	The	the	DT
cord-300872-blycbi4u	127	2	newly	newly	RB
cord-300872-blycbi4u	127	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	127	4	sulfonate	sulfonate	NN
cord-300872-blycbi4u	127	5	15	15	CD
cord-300872-blycbi4u	127	6	derivatives	derivative	NNS
cord-300872-blycbi4u	127	7	were	be	VBD
cord-300872-blycbi4u	127	8	tested	test	VBN
cord-300872-blycbi4u	127	9	against	against	IN
cord-300872-blycbi4u	127	10	several	several	JJ
cord-300872-blycbi4u	127	11	bacterial	bacterial	JJ
cord-300872-blycbi4u	127	12	strains	strain	NNS
cord-300872-blycbi4u	127	13	,	,	,
cord-300872-blycbi4u	127	14	such	such	JJ
cord-300872-blycbi4u	127	15	as	as	IN
cord-300872-blycbi4u	127	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	127	17	aureus	aureus	NN
cord-300872-blycbi4u	127	18	and	and	CC
cord-300872-blycbi4u	127	19	Bacillus	Bacillus	NNP
cord-300872-blycbi4u	127	20	megaterium	megaterium	NN
cord-300872-blycbi4u	128	1	(	(	-LRB-
cord-300872-blycbi4u	128	2	Gram	gram	NN
cord-300872-blycbi4u	128	3	-	-	HYPH
cord-300872-blycbi4u	128	4	positive	positive	JJ
cord-300872-blycbi4u	128	5	bacteria	bacteria	NNS
cord-300872-blycbi4u	128	6	)	)	-RRB-
cord-300872-blycbi4u	128	7	,	,	,
cord-300872-blycbi4u	128	8	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	128	9	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	128	10	and	and	CC
cord-300872-blycbi4u	128	11	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	128	12	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	128	13	(	(	-LRB-
cord-300872-blycbi4u	128	14	Gram	gram	NN
cord-300872-blycbi4u	128	15	-	-	HYPH
cord-300872-blycbi4u	128	16	negative	negative	JJ
cord-300872-blycbi4u	128	17	bacteria	bacteria	NNS
cord-300872-blycbi4u	128	18	)	)	-RRB-
cord-300872-blycbi4u	128	19	,	,	,
cord-300872-blycbi4u	128	20	and	and	CC
cord-300872-blycbi4u	128	21	against	against	IN
cord-300872-blycbi4u	128	22	two	two	CD
cord-300872-blycbi4u	128	23	Gram	gram	NN
cord-300872-blycbi4u	128	24	-	-	HYPH
cord-300872-blycbi4u	128	25	negative	negative	JJ
cord-300872-blycbi4u	128	26	,	,	,
cord-300872-blycbi4u	128	27	antibioticresistant	antibioticresistant	JJ
cord-300872-blycbi4u	128	28	E.	E.	NNP
cord-300872-blycbi4u	128	29	coli	coli	VBZ
cord-300872-blycbi4u	128	30	bacterial	bacterial	JJ
cord-300872-blycbi4u	128	31	strains	strain	NNS
cord-300872-blycbi4u	128	32	,	,	,
cord-300872-blycbi4u	128	33	namely	namely	RB
cord-300872-blycbi4u	128	34	mutant	mutant	JJ
cord-300872-blycbi4u	128	35	E.	E.	NNP
cord-300872-blycbi4u	128	36	coli	coli	NNS
cord-300872-blycbi4u	128	37	(	(	-LRB-
cord-300872-blycbi4u	128	38	Streptomycin	Streptomycin	NNP
cord-300872-blycbi4u	128	39	-	-	HYPH
cord-300872-blycbi4u	128	40	resistant	resistant	JJ
cord-300872-blycbi4u	128	41	)	)	-RRB-
cord-300872-blycbi4u	128	42	and	and	CC
cord-300872-blycbi4u	128	43	donor	donor	NN
cord-300872-blycbi4u	128	44	E.	E.	NNP
cord-300872-blycbi4u	128	45	coli	coli	NNS
cord-300872-blycbi4u	128	46	(	(	-LRB-
cord-300872-blycbi4u	128	47	Rifampin	rifampin	NN
cord-300872-blycbi4u	128	48	-	-	HYPH
cord-300872-blycbi4u	128	49	resistant	resistant	JJ
cord-300872-blycbi4u	128	50	)	)	-RRB-
cord-300872-blycbi4u	128	51	,	,	,
cord-300872-blycbi4u	128	52	using	use	VBG
cord-300872-blycbi4u	128	53	the	the	DT
cord-300872-blycbi4u	128	54	agar	agar	NNP
cord-300872-blycbi4u	128	55	well	well	NNP
cord-300872-blycbi4u	128	56	diffusion	diffusion	NN
cord-300872-blycbi4u	128	57	method	method	NN
cord-300872-blycbi4u	128	58	;	;	:
cord-300872-blycbi4u	128	59	amoxiclav	amoxiclav	NNP
cord-300872-blycbi4u	128	60	(	(	-LRB-
cord-300872-blycbi4u	128	61	Ac	Ac	NNP
cord-300872-blycbi4u	128	62	)	)	-RRB-
cord-300872-blycbi4u	128	63	was	be	VBD
cord-300872-blycbi4u	128	64	used	use	VBN
cord-300872-blycbi4u	128	65	as	as	IN
cord-300872-blycbi4u	128	66	the	the	DT
cord-300872-blycbi4u	128	67	standard	standard	JJ
cord-300872-blycbi4u	128	68	drug	drug	NN
cord-300872-blycbi4u	128	69	.	.	.
cord-300872-blycbi4u	129	1	Among	among	IN
cord-300872-blycbi4u	129	2	the	the	DT
cord-300872-blycbi4u	129	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	129	4	compounds	compound	NNS
cord-300872-blycbi4u	129	5	,	,	,
cord-300872-blycbi4u	129	6	derivatives	derivative	NNS
cord-300872-blycbi4u	129	7	with	with	IN
cord-300872-blycbi4u	129	8	an	an	DT
cord-300872-blycbi4u	129	9	aryl	aryl	NN
cord-300872-blycbi4u	129	10	group	group	NN
cord-300872-blycbi4u	129	11	showed	show	VBD
cord-300872-blycbi4u	129	12	potent	potent	JJ
cord-300872-blycbi4u	129	13	activity	activity	NN
cord-300872-blycbi4u	129	14	.	.	.
cord-300872-blycbi4u	130	1	For	for	IN
cord-300872-blycbi4u	130	2	example	example	NN
cord-300872-blycbi4u	130	3	,	,	,
cord-300872-blycbi4u	130	4	the	the	DT
cord-300872-blycbi4u	130	5	compound	compound	NN
cord-300872-blycbi4u	130	6	with	with	IN
cord-300872-blycbi4u	130	7	Ar	Ar	NNP
cord-300872-blycbi4u	131	1	=	=	NFP
cord-300872-blycbi4u	131	2	biphenyl	biphenyl	NNP
cord-300872-blycbi4u	131	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	131	4	potent	potent	JJ
cord-300872-blycbi4u	131	5	activity	activity	NN
cord-300872-blycbi4u	131	6	against	against	IN
cord-300872-blycbi4u	131	7	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	131	8	aureus	aureus	NN
cord-300872-blycbi4u	131	9	,	,	,
cord-300872-blycbi4u	131	10	with	with	IN
cord-300872-blycbi4u	131	11	an	an	DT
cord-300872-blycbi4u	131	12	inhibition	inhibition	NN
cord-300872-blycbi4u	131	13	zone	zone	NN
cord-300872-blycbi4u	131	14	of	of	IN
cord-300872-blycbi4u	131	15	22	22	CD
cord-300872-blycbi4u	131	16	mm	mm	NNS
cord-300872-blycbi4u	131	17	compared	compare	VBN
cord-300872-blycbi4u	131	18	to	to	IN
cord-300872-blycbi4u	131	19	the	the	DT
cord-300872-blycbi4u	131	20	reference	reference	NN
cord-300872-blycbi4u	131	21	drug	drug	NN
cord-300872-blycbi4u	131	22	(	(	-LRB-
cord-300872-blycbi4u	131	23	24	24	CD
cord-300872-blycbi4u	131	24	mm	mm	NNP
cord-300872-blycbi4u	131	25	)	)	-RRB-
cord-300872-blycbi4u	131	26	.	.	.
cord-300872-blycbi4u	132	1	On	on	IN
cord-300872-blycbi4u	132	2	the	the	DT
cord-300872-blycbi4u	132	3	other	other	JJ
cord-300872-blycbi4u	132	4	hand	hand	NN
cord-300872-blycbi4u	132	5	,	,	,
cord-300872-blycbi4u	132	6	derivatives	derivative	NNS
cord-300872-blycbi4u	132	7	with	with	IN
cord-300872-blycbi4u	132	8	Ar	Ar	NNP
cord-300872-blycbi4u	132	9	=	=	SYM
cord-300872-blycbi4u	132	10	4-FPh	4-fph	CD
cord-300872-blycbi4u	132	11	and	and	CC
cord-300872-blycbi4u	132	12	2-OH-5-NO2Ph	2-oh-5-no2ph	CD
cord-300872-blycbi4u	132	13	displayed	display	VBD
cord-300872-blycbi4u	132	14	potent	potent	JJ
cord-300872-blycbi4u	132	15	activity	activity	NN
cord-300872-blycbi4u	132	16	against	against	IN
cord-300872-blycbi4u	132	17	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	132	18	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	132	19	,	,	,
cord-300872-blycbi4u	132	20	with	with	IN
cord-300872-blycbi4u	132	21	inhibition	inhibition	NN
cord-300872-blycbi4u	132	22	zones	zone	NNS
cord-300872-blycbi4u	132	23	of	of	IN
cord-300872-blycbi4u	132	24	22	22	CD
cord-300872-blycbi4u	132	25	mm	mm	NNS
cord-300872-blycbi4u	132	26	and	and	CC
cord-300872-blycbi4u	132	27	23	23	CD
cord-300872-blycbi4u	132	28	mm	mm	NNS
cord-300872-blycbi4u	132	29	,	,	,
cord-300872-blycbi4u	132	30	respectively	respectively	RB
cord-300872-blycbi4u	132	31	,	,	,
cord-300872-blycbi4u	132	32	compared	compare	VBN
cord-300872-blycbi4u	132	33	to	to	IN
cord-300872-blycbi4u	132	34	the	the	DT
cord-300872-blycbi4u	132	35	standard	standard	JJ
cord-300872-blycbi4u	132	36	drug	drug	NN
cord-300872-blycbi4u	132	37	(	(	-LRB-
cord-300872-blycbi4u	132	38	24	24	CD
cord-300872-blycbi4u	132	39	mm	mm	NNP
cord-300872-blycbi4u	132	40	)	)	-RRB-
cord-300872-blycbi4u	132	41	,	,	,
cord-300872-blycbi4u	132	42	whereas	whereas	IN
cord-300872-blycbi4u	132	43	the	the	DT
cord-300872-blycbi4u	132	44	derivative	derivative	NN
cord-300872-blycbi4u	132	45	with	with	IN
cord-300872-blycbi4u	132	46	R	r	NN
cord-300872-blycbi4u	132	47	=	=	NN
cord-300872-blycbi4u	132	48	4-CH3Ph	4-ch3ph	CD
cord-300872-blycbi4u	132	49	was	be	VBD
cord-300872-blycbi4u	132	50	potent	potent	JJ
cord-300872-blycbi4u	132	51	against	against	IN
cord-300872-blycbi4u	132	52	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	132	53	pneumonia	pneumonia	NN
cord-300872-blycbi4u	132	54	,	,	,
cord-300872-blycbi4u	132	55	with	with	IN
cord-300872-blycbi4u	132	56	an	an	DT
cord-300872-blycbi4u	132	57	inhibition	inhibition	NN
cord-300872-blycbi4u	132	58	zone	zone	NN
cord-300872-blycbi4u	132	59	of	of	IN
cord-300872-blycbi4u	132	60	25	25	CD
cord-300872-blycbi4u	132	61	mm	mm	NNS
cord-300872-blycbi4u	132	62	compared	compare	VBN
cord-300872-blycbi4u	132	63	to	to	IN
cord-300872-blycbi4u	132	64	the	the	DT
cord-300872-blycbi4u	132	65	standard	standard	JJ
cord-300872-blycbi4u	132	66	drug	drug	NN
cord-300872-blycbi4u	132	67	(	(	-LRB-
cord-300872-blycbi4u	132	68	27	27	CD
cord-300872-blycbi4u	132	69	mm	mm	NN
cord-300872-blycbi4u	132	70	These	these	DT
cord-300872-blycbi4u	132	71	compounds	compound	NNS
cord-300872-blycbi4u	132	72	were	be	VBD
cord-300872-blycbi4u	132	73	tested	test	VBN
cord-300872-blycbi4u	132	74	as	as	IN
cord-300872-blycbi4u	132	75	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	132	76	agents	agent	NNS
cord-300872-blycbi4u	132	77	against	against	IN
cord-300872-blycbi4u	132	78	six	six	CD
cord-300872-blycbi4u	132	79	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	132	80	strains	strain	NNS
cord-300872-blycbi4u	132	81	,	,	,
cord-300872-blycbi4u	132	82	including	include	VBG
cord-300872-blycbi4u	132	83	E.	E.	NNP
cord-300872-blycbi4u	132	84	cloacae	cloacae	NN
cord-300872-blycbi4u	132	85	,	,	,
cord-300872-blycbi4u	132	86	E.	E.	NNP
cord-300872-blycbi4u	132	87	coli	coli	NNS
cord-300872-blycbi4u	132	88	,	,	,
cord-300872-blycbi4u	132	89	K.	K.	NNP
cord-300872-blycbi4u	132	90	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	132	91	,	,	,
cord-300872-blycbi4u	132	92	P.	P.	NNP
cord-300872-blycbi4u	132	93	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	132	94	,	,	,
cord-300872-blycbi4u	132	95	S.	S.	NNP
cord-300872-blycbi4u	132	96	aureus	aureus	NN
cord-300872-blycbi4u	132	97	,	,	,
cord-300872-blycbi4u	132	98	and	and	CC
cord-300872-blycbi4u	132	99	A.	a.	NN
cord-300872-blycbi4u	132	100	baumanii	baumanii	NN
cord-300872-blycbi4u	132	101	.	.	.
cord-300872-blycbi4u	133	1	Minimal	minimal	JJ
cord-300872-blycbi4u	133	2	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	133	3	concentrations	concentration	NNS
cord-300872-blycbi4u	133	4	of	of	IN
cord-300872-blycbi4u	133	5	these	these	DT
cord-300872-blycbi4u	133	6	compounds	compound	NNS
cord-300872-blycbi4u	133	7	were	be	VBD
cord-300872-blycbi4u	133	8	calculated	calculate	VBN
cord-300872-blycbi4u	133	9	and	and	CC
cord-300872-blycbi4u	133	10	compared	compare	VBN
cord-300872-blycbi4u	133	11	with	with	IN
cord-300872-blycbi4u	133	12	three	three	CD
cord-300872-blycbi4u	133	13	standard	standard	JJ
cord-300872-blycbi4u	133	14	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	133	15	,	,	,
cord-300872-blycbi4u	133	16	namely	namely	RB
cord-300872-blycbi4u	133	17	penicillin	penicillin	NN
cord-300872-blycbi4u	133	18	G	G	NNP
cord-300872-blycbi4u	133	19	,	,	,
cord-300872-blycbi4u	133	20	norfloxacin	norfloxacin	NNS
cord-300872-blycbi4u	133	21	,	,	,
cord-300872-blycbi4u	133	22	and	and	CC
cord-300872-blycbi4u	133	23	erythromycin	erythromycin	NN
cord-300872-blycbi4u	133	24	,	,	,
cord-300872-blycbi4u	133	25	using	use	VBG
cord-300872-blycbi4u	133	26	the	the	DT
cord-300872-blycbi4u	133	27	disk	disk	NN
cord-300872-blycbi4u	133	28	diffusion	diffusion	NN
cord-300872-blycbi4u	133	29	technique	technique	NN
cord-300872-blycbi4u	133	30	.	.	.
cord-300872-blycbi4u	134	1	Some	some	DT
cord-300872-blycbi4u	134	2	of	of	IN
cord-300872-blycbi4u	134	3	these	these	DT
cord-300872-blycbi4u	134	4	prepared	prepared	JJ
cord-300872-blycbi4u	134	5	compounds	compound	NNS
cord-300872-blycbi4u	134	6	exhibited	exhibit	VBD
cord-300872-blycbi4u	134	7	remarkable	remarkable	JJ
cord-300872-blycbi4u	134	8	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	134	9	activity	activity	NN
cord-300872-blycbi4u	134	10	against	against	IN
cord-300872-blycbi4u	134	11	Gram	gram	NN
cord-300872-blycbi4u	134	12	-	-	HYPH
cord-300872-blycbi4u	134	13	positive	positive	JJ
cord-300872-blycbi4u	134	14	and	and	CC
cord-300872-blycbi4u	134	15	Gramnegative	gramnegative	JJ
cord-300872-blycbi4u	134	16	strains	strain	NNS
cord-300872-blycbi4u	134	17	compared	compare	VBN
cord-300872-blycbi4u	134	18	to	to	IN
cord-300872-blycbi4u	134	19	the	the	DT
cord-300872-blycbi4u	134	20	standard	standard	JJ
cord-300872-blycbi4u	134	21	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	134	22	used	use	VBN
cord-300872-blycbi4u	134	23	.	.	.
cord-300872-blycbi4u	135	1	One	one	CD
cord-300872-blycbi4u	135	2	derivative	derivative	JJ
cord-300872-blycbi4u	135	3	(	(	-LRB-
cord-300872-blycbi4u	135	4	R	r	NN
cord-300872-blycbi4u	135	5	=	=	SYM
cord-300872-blycbi4u	135	6	NO2	NO2	NNP
cord-300872-blycbi4u	135	7	,	,	,
cord-300872-blycbi4u	135	8	R′	r′	NN
cord-300872-blycbi4u	135	9	=	=	SYM
cord-300872-blycbi4u	135	10	H	h	NN
cord-300872-blycbi4u	135	11	)	)	-RRB-
cord-300872-blycbi4u	135	12	was	be	VBD
cord-300872-blycbi4u	135	13	more	more	RBR
cord-300872-blycbi4u	135	14	potent	potent	JJ
cord-300872-blycbi4u	135	15	than	than	IN
cord-300872-blycbi4u	135	16	the	the	DT
cord-300872-blycbi4u	135	17	standard	standard	JJ
cord-300872-blycbi4u	135	18	drugs	drug	NNS
cord-300872-blycbi4u	135	19	and	and	CC
cord-300872-blycbi4u	135	20	showed	show	VBD
cord-300872-blycbi4u	135	21	activity	activity	NN
cord-300872-blycbi4u	135	22	against	against	IN
cord-300872-blycbi4u	135	23	E.	E.	NNP
cord-300872-blycbi4u	135	24	cloacae	cloacae	NNP
cord-300872-blycbi4u	135	25	,	,	,
cord-300872-blycbi4u	135	26	K.	K.	NNP
cord-300872-blycbi4u	135	27	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	135	28	,	,	,
cord-300872-blycbi4u	135	29	S.	S.	NNP
cord-300872-blycbi4u	135	30	aureus	aureus	NN
cord-300872-blycbi4u	135	31	,	,	,
cord-300872-blycbi4u	136	1	The	the	DT
cord-300872-blycbi4u	136	2	newly	newly	RB
cord-300872-blycbi4u	136	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	136	4	sulfonate	sulfonate	NN
cord-300872-blycbi4u	136	5	15	15	CD
cord-300872-blycbi4u	136	6	derivatives	derivative	NNS
cord-300872-blycbi4u	136	7	were	be	VBD
cord-300872-blycbi4u	136	8	tested	test	VBN
cord-300872-blycbi4u	136	9	against	against	IN
cord-300872-blycbi4u	136	10	several	several	JJ
cord-300872-blycbi4u	136	11	bacterial	bacterial	JJ
cord-300872-blycbi4u	136	12	strains	strain	NNS
cord-300872-blycbi4u	136	13	,	,	,
cord-300872-blycbi4u	136	14	such	such	JJ
cord-300872-blycbi4u	136	15	as	as	IN
cord-300872-blycbi4u	136	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	136	17	aureus	aureus	NN
cord-300872-blycbi4u	136	18	and	and	CC
cord-300872-blycbi4u	136	19	Bacillus	Bacillus	NNP
cord-300872-blycbi4u	136	20	megaterium	megaterium	NN
cord-300872-blycbi4u	137	1	(	(	-LRB-
cord-300872-blycbi4u	137	2	Gram	gram	NN
cord-300872-blycbi4u	137	3	-	-	HYPH
cord-300872-blycbi4u	137	4	positive	positive	JJ
cord-300872-blycbi4u	137	5	bacteria	bacteria	NNS
cord-300872-blycbi4u	137	6	)	)	-RRB-
cord-300872-blycbi4u	137	7	,	,	,
cord-300872-blycbi4u	137	8	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	137	9	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	137	10	and	and	CC
cord-300872-blycbi4u	137	11	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	137	12	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	137	13	(	(	-LRB-
cord-300872-blycbi4u	137	14	Gram	gram	NN
cord-300872-blycbi4u	137	15	-	-	HYPH
cord-300872-blycbi4u	137	16	negative	negative	JJ
cord-300872-blycbi4u	137	17	bacteria	bacteria	NNS
cord-300872-blycbi4u	137	18	)	)	-RRB-
cord-300872-blycbi4u	137	19	,	,	,
cord-300872-blycbi4u	137	20	and	and	CC
cord-300872-blycbi4u	137	21	against	against	IN
cord-300872-blycbi4u	137	22	two	two	CD
cord-300872-blycbi4u	137	23	Gram	gram	NN
cord-300872-blycbi4u	137	24	-	-	HYPH
cord-300872-blycbi4u	137	25	negative	negative	JJ
cord-300872-blycbi4u	137	26	,	,	,
cord-300872-blycbi4u	137	27	antibiotic	antibiotic	JJ
cord-300872-blycbi4u	137	28	-	-	HYPH
cord-300872-blycbi4u	137	29	resistant	resistant	JJ
cord-300872-blycbi4u	137	30	E.	E.	NNP
cord-300872-blycbi4u	137	31	coli	coli	NNS
cord-300872-blycbi4u	137	32	bacterial	bacterial	JJ
cord-300872-blycbi4u	137	33	strains	strain	NNS
cord-300872-blycbi4u	137	34	,	,	,
cord-300872-blycbi4u	137	35	namely	namely	RB
cord-300872-blycbi4u	137	36	mutant	mutant	JJ
cord-300872-blycbi4u	137	37	E.	E.	NNP
cord-300872-blycbi4u	137	38	coli	coli	NNS
cord-300872-blycbi4u	137	39	(	(	-LRB-
cord-300872-blycbi4u	137	40	Streptomycin	Streptomycin	NNP
cord-300872-blycbi4u	137	41	-	-	HYPH
cord-300872-blycbi4u	137	42	resistant	resistant	JJ
cord-300872-blycbi4u	137	43	)	)	-RRB-
cord-300872-blycbi4u	137	44	and	and	CC
cord-300872-blycbi4u	137	45	donor	donor	NN
cord-300872-blycbi4u	137	46	E.	E.	NNP
cord-300872-blycbi4u	137	47	coli	coli	NNS
cord-300872-blycbi4u	137	48	(	(	-LRB-
cord-300872-blycbi4u	137	49	Rifampin	rifampin	NN
cord-300872-blycbi4u	137	50	-	-	HYPH
cord-300872-blycbi4u	137	51	resistant	resistant	JJ
cord-300872-blycbi4u	137	52	)	)	-RRB-
cord-300872-blycbi4u	137	53	,	,	,
cord-300872-blycbi4u	137	54	using	use	VBG
cord-300872-blycbi4u	137	55	the	the	DT
cord-300872-blycbi4u	137	56	agar	agar	NNP
cord-300872-blycbi4u	137	57	well	well	NNP
cord-300872-blycbi4u	137	58	diffusion	diffusion	NN
cord-300872-blycbi4u	137	59	method	method	NN
cord-300872-blycbi4u	137	60	;	;	:
cord-300872-blycbi4u	137	61	amoxiclav	amoxiclav	NNP
cord-300872-blycbi4u	137	62	(	(	-LRB-
cord-300872-blycbi4u	137	63	Ac	Ac	NNP
cord-300872-blycbi4u	137	64	)	)	-RRB-
cord-300872-blycbi4u	137	65	was	be	VBD
cord-300872-blycbi4u	137	66	used	use	VBN
cord-300872-blycbi4u	137	67	as	as	IN
cord-300872-blycbi4u	137	68	the	the	DT
cord-300872-blycbi4u	137	69	standard	standard	JJ
cord-300872-blycbi4u	137	70	drug	drug	NN
cord-300872-blycbi4u	137	71	.	.	.
cord-300872-blycbi4u	138	1	Among	among	IN
cord-300872-blycbi4u	138	2	the	the	DT
cord-300872-blycbi4u	138	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	138	4	compounds	compound	NNS
cord-300872-blycbi4u	138	5	,	,	,
cord-300872-blycbi4u	138	6	derivatives	derivative	NNS
cord-300872-blycbi4u	138	7	with	with	IN
cord-300872-blycbi4u	138	8	an	an	DT
cord-300872-blycbi4u	138	9	aryl	aryl	NN
cord-300872-blycbi4u	138	10	group	group	NN
cord-300872-blycbi4u	138	11	showed	show	VBD
cord-300872-blycbi4u	138	12	potent	potent	JJ
cord-300872-blycbi4u	138	13	activity	activity	NN
cord-300872-blycbi4u	138	14	.	.	.
cord-300872-blycbi4u	139	1	For	for	IN
cord-300872-blycbi4u	139	2	example	example	NN
cord-300872-blycbi4u	139	3	,	,	,
cord-300872-blycbi4u	139	4	the	the	DT
cord-300872-blycbi4u	139	5	compound	compound	NN
cord-300872-blycbi4u	139	6	with	with	IN
cord-300872-blycbi4u	139	7	Ar	Ar	NNP
cord-300872-blycbi4u	140	1	=	=	NFP
cord-300872-blycbi4u	140	2	biphenyl	biphenyl	NNP
cord-300872-blycbi4u	140	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	140	4	potent	potent	JJ
cord-300872-blycbi4u	140	5	activity	activity	NN
cord-300872-blycbi4u	140	6	against	against	IN
cord-300872-blycbi4u	140	7	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	140	8	aureus	aureus	NN
cord-300872-blycbi4u	140	9	,	,	,
cord-300872-blycbi4u	140	10	with	with	IN
cord-300872-blycbi4u	140	11	an	an	DT
cord-300872-blycbi4u	140	12	inhibition	inhibition	NN
cord-300872-blycbi4u	140	13	zone	zone	NN
cord-300872-blycbi4u	140	14	of	of	IN
cord-300872-blycbi4u	140	15	22	22	CD
cord-300872-blycbi4u	140	16	mm	mm	NNS
cord-300872-blycbi4u	140	17	compared	compare	VBN
cord-300872-blycbi4u	140	18	to	to	IN
cord-300872-blycbi4u	140	19	the	the	DT
cord-300872-blycbi4u	140	20	reference	reference	NN
cord-300872-blycbi4u	140	21	drug	drug	NN
cord-300872-blycbi4u	140	22	(	(	-LRB-
cord-300872-blycbi4u	140	23	24	24	CD
cord-300872-blycbi4u	140	24	mm	mm	NNP
cord-300872-blycbi4u	140	25	)	)	-RRB-
cord-300872-blycbi4u	140	26	.	.	.
cord-300872-blycbi4u	141	1	On	on	IN
cord-300872-blycbi4u	141	2	the	the	DT
cord-300872-blycbi4u	141	3	other	other	JJ
cord-300872-blycbi4u	141	4	hand	hand	NN
cord-300872-blycbi4u	141	5	,	,	,
cord-300872-blycbi4u	141	6	derivatives	derivative	NNS
cord-300872-blycbi4u	141	7	with	with	IN
cord-300872-blycbi4u	141	8	Ar	Ar	NNP
cord-300872-blycbi4u	141	9	=	=	SYM
cord-300872-blycbi4u	141	10	4-FPh	4-fph	CD
cord-300872-blycbi4u	141	11	and	and	CC
cord-300872-blycbi4u	141	12	2-OH-5-NO	2-oh-5-no	CD
cord-300872-blycbi4u	141	13	2	2	CD
cord-300872-blycbi4u	142	1	Ph	Ph	NNP
cord-300872-blycbi4u	142	2	displayed	display	VBD
cord-300872-blycbi4u	142	3	potent	potent	JJ
cord-300872-blycbi4u	142	4	activity	activity	NN
cord-300872-blycbi4u	142	5	against	against	IN
cord-300872-blycbi4u	142	6	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	142	7	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	142	8	,	,	,
cord-300872-blycbi4u	142	9	with	with	IN
cord-300872-blycbi4u	142	10	inhibition	inhibition	NN
cord-300872-blycbi4u	142	11	zones	zone	NNS
cord-300872-blycbi4u	142	12	of	of	IN
cord-300872-blycbi4u	142	13	22	22	CD
cord-300872-blycbi4u	142	14	mm	mm	NNS
cord-300872-blycbi4u	142	15	and	and	CC
cord-300872-blycbi4u	142	16	23	23	CD
cord-300872-blycbi4u	142	17	mm	mm	NNS
cord-300872-blycbi4u	142	18	,	,	,
cord-300872-blycbi4u	142	19	respectively	respectively	RB
cord-300872-blycbi4u	142	20	,	,	,
cord-300872-blycbi4u	142	21	compared	compare	VBN
cord-300872-blycbi4u	142	22	to	to	IN
cord-300872-blycbi4u	142	23	the	the	DT
cord-300872-blycbi4u	142	24	standard	standard	JJ
cord-300872-blycbi4u	142	25	drug	drug	NN
cord-300872-blycbi4u	142	26	(	(	-LRB-
cord-300872-blycbi4u	142	27	24	24	CD
cord-300872-blycbi4u	142	28	mm	mm	NNP
cord-300872-blycbi4u	142	29	)	)	-RRB-
cord-300872-blycbi4u	142	30	,	,	,
cord-300872-blycbi4u	142	31	whereas	whereas	IN
cord-300872-blycbi4u	142	32	the	the	DT
cord-300872-blycbi4u	142	33	derivative	derivative	NN
cord-300872-blycbi4u	142	34	with	with	IN
cord-300872-blycbi4u	142	35	R	r	NN
cord-300872-blycbi4u	142	36	=	=	SYM
cord-300872-blycbi4u	142	37	4-CH	4-ch	CD
cord-300872-blycbi4u	142	38	3	3	CD
cord-300872-blycbi4u	143	1	Ph	Ph	NNP
cord-300872-blycbi4u	143	2	was	be	VBD
cord-300872-blycbi4u	143	3	potent	potent	JJ
cord-300872-blycbi4u	143	4	against	against	IN
cord-300872-blycbi4u	143	5	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	143	6	pneumonia	pneumonia	NN
cord-300872-blycbi4u	143	7	,	,	,
cord-300872-blycbi4u	143	8	with	with	IN
cord-300872-blycbi4u	143	9	an	an	DT
cord-300872-blycbi4u	143	10	inhibition	inhibition	NN
cord-300872-blycbi4u	143	11	zone	zone	NN
cord-300872-blycbi4u	143	12	of	of	IN
cord-300872-blycbi4u	143	13	25	25	CD
cord-300872-blycbi4u	143	14	mm	mm	NNS
cord-300872-blycbi4u	143	15	compared	compare	VBN
cord-300872-blycbi4u	143	16	to	to	IN
cord-300872-blycbi4u	143	17	the	the	DT
cord-300872-blycbi4u	143	18	standard	standard	JJ
cord-300872-blycbi4u	143	19	drug	drug	NN
cord-300872-blycbi4u	143	20	(	(	-LRB-
cord-300872-blycbi4u	143	21	27	27	CD
cord-300872-blycbi4u	143	22	mm	mm	NN
cord-300872-blycbi4u	143	23	)	)	-RRB-
cord-300872-blycbi4u	143	24	.	.	.
cord-300872-blycbi4u	144	1	A	a	DT
cord-300872-blycbi4u	144	2	study	study	NN
cord-300872-blycbi4u	144	3	published	publish	VBN
cord-300872-blycbi4u	144	4	by	by	IN
cord-300872-blycbi4u	144	5	Rbaa	Rbaa	NNP
cord-300872-blycbi4u	145	1	The	the	DT
cord-300872-blycbi4u	145	2	newly	newly	RB
cord-300872-blycbi4u	145	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	145	4	sulfonate	sulfonate	NN
cord-300872-blycbi4u	145	5	15	15	CD
cord-300872-blycbi4u	145	6	derivatives	derivative	NNS
cord-300872-blycbi4u	145	7	were	be	VBD
cord-300872-blycbi4u	145	8	tested	test	VBN
cord-300872-blycbi4u	145	9	against	against	IN
cord-300872-blycbi4u	145	10	several	several	JJ
cord-300872-blycbi4u	145	11	bacterial	bacterial	JJ
cord-300872-blycbi4u	145	12	strains	strain	NNS
cord-300872-blycbi4u	145	13	,	,	,
cord-300872-blycbi4u	145	14	such	such	JJ
cord-300872-blycbi4u	145	15	as	as	IN
cord-300872-blycbi4u	145	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	145	17	aureus	aureus	NN
cord-300872-blycbi4u	145	18	and	and	CC
cord-300872-blycbi4u	145	19	Bacillus	Bacillus	NNP
cord-300872-blycbi4u	145	20	megaterium	megaterium	NN
cord-300872-blycbi4u	146	1	(	(	-LRB-
cord-300872-blycbi4u	146	2	Gram	gram	NN
cord-300872-blycbi4u	146	3	-	-	HYPH
cord-300872-blycbi4u	146	4	positive	positive	JJ
cord-300872-blycbi4u	146	5	bacteria	bacteria	NNS
cord-300872-blycbi4u	146	6	)	)	-RRB-
cord-300872-blycbi4u	146	7	,	,	,
cord-300872-blycbi4u	146	8	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	146	9	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	146	10	and	and	CC
cord-300872-blycbi4u	146	11	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	146	12	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	146	13	(	(	-LRB-
cord-300872-blycbi4u	146	14	Gram	gram	NN
cord-300872-blycbi4u	146	15	-	-	HYPH
cord-300872-blycbi4u	146	16	negative	negative	JJ
cord-300872-blycbi4u	146	17	bacteria	bacteria	NNS
cord-300872-blycbi4u	146	18	)	)	-RRB-
cord-300872-blycbi4u	146	19	,	,	,
cord-300872-blycbi4u	146	20	and	and	CC
cord-300872-blycbi4u	146	21	against	against	IN
cord-300872-blycbi4u	146	22	two	two	CD
cord-300872-blycbi4u	146	23	Gram	gram	NN
cord-300872-blycbi4u	146	24	-	-	HYPH
cord-300872-blycbi4u	146	25	negative	negative	JJ
cord-300872-blycbi4u	146	26	,	,	,
cord-300872-blycbi4u	146	27	antibioticresistant	antibioticresistant	JJ
cord-300872-blycbi4u	146	28	E.	E.	NNP
cord-300872-blycbi4u	146	29	coli	coli	VBZ
cord-300872-blycbi4u	146	30	bacterial	bacterial	JJ
cord-300872-blycbi4u	146	31	strains	strain	NNS
cord-300872-blycbi4u	146	32	,	,	,
cord-300872-blycbi4u	146	33	namely	namely	RB
cord-300872-blycbi4u	146	34	mutant	mutant	JJ
cord-300872-blycbi4u	146	35	E.	E.	NNP
cord-300872-blycbi4u	146	36	coli	coli	NNS
cord-300872-blycbi4u	146	37	(	(	-LRB-
cord-300872-blycbi4u	146	38	Streptomycin	Streptomycin	NNP
cord-300872-blycbi4u	146	39	-	-	HYPH
cord-300872-blycbi4u	146	40	resistant	resistant	JJ
cord-300872-blycbi4u	146	41	)	)	-RRB-
cord-300872-blycbi4u	146	42	and	and	CC
cord-300872-blycbi4u	146	43	donor	donor	NN
cord-300872-blycbi4u	146	44	E.	E.	NNP
cord-300872-blycbi4u	146	45	coli	coli	NNS
cord-300872-blycbi4u	146	46	(	(	-LRB-
cord-300872-blycbi4u	146	47	Rifampin	rifampin	NN
cord-300872-blycbi4u	146	48	-	-	HYPH
cord-300872-blycbi4u	146	49	resistant	resistant	JJ
cord-300872-blycbi4u	146	50	)	)	-RRB-
cord-300872-blycbi4u	146	51	,	,	,
cord-300872-blycbi4u	146	52	using	use	VBG
cord-300872-blycbi4u	146	53	the	the	DT
cord-300872-blycbi4u	146	54	agar	agar	NNP
cord-300872-blycbi4u	146	55	well	well	NNP
cord-300872-blycbi4u	146	56	diffusion	diffusion	NN
cord-300872-blycbi4u	146	57	method	method	NN
cord-300872-blycbi4u	146	58	;	;	:
cord-300872-blycbi4u	146	59	amoxiclav	amoxiclav	NNP
cord-300872-blycbi4u	146	60	(	(	-LRB-
cord-300872-blycbi4u	146	61	Ac	Ac	NNP
cord-300872-blycbi4u	146	62	)	)	-RRB-
cord-300872-blycbi4u	146	63	was	be	VBD
cord-300872-blycbi4u	146	64	used	use	VBN
cord-300872-blycbi4u	146	65	as	as	IN
cord-300872-blycbi4u	146	66	the	the	DT
cord-300872-blycbi4u	146	67	standard	standard	JJ
cord-300872-blycbi4u	146	68	drug	drug	NN
cord-300872-blycbi4u	146	69	.	.	.
cord-300872-blycbi4u	147	1	Among	among	IN
cord-300872-blycbi4u	147	2	the	the	DT
cord-300872-blycbi4u	147	3	synthesized	synthesize	VBN
cord-300872-blycbi4u	147	4	compounds	compound	NNS
cord-300872-blycbi4u	147	5	,	,	,
cord-300872-blycbi4u	147	6	derivatives	derivative	NNS
cord-300872-blycbi4u	147	7	with	with	IN
cord-300872-blycbi4u	147	8	an	an	DT
cord-300872-blycbi4u	147	9	aryl	aryl	NN
cord-300872-blycbi4u	147	10	group	group	NN
cord-300872-blycbi4u	147	11	showed	show	VBD
cord-300872-blycbi4u	147	12	potent	potent	JJ
cord-300872-blycbi4u	147	13	activity	activity	NN
cord-300872-blycbi4u	147	14	.	.	.
cord-300872-blycbi4u	148	1	For	for	IN
cord-300872-blycbi4u	148	2	example	example	NN
cord-300872-blycbi4u	148	3	,	,	,
cord-300872-blycbi4u	148	4	the	the	DT
cord-300872-blycbi4u	148	5	compound	compound	NN
cord-300872-blycbi4u	148	6	with	with	IN
cord-300872-blycbi4u	148	7	Ar	Ar	NNP
cord-300872-blycbi4u	149	1	=	=	NFP
cord-300872-blycbi4u	149	2	biphenyl	biphenyl	NNP
cord-300872-blycbi4u	149	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	149	4	potent	potent	JJ
cord-300872-blycbi4u	149	5	activity	activity	NN
cord-300872-blycbi4u	149	6	against	against	IN
cord-300872-blycbi4u	149	7	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	149	8	aureus	aureus	NN
cord-300872-blycbi4u	149	9	,	,	,
cord-300872-blycbi4u	149	10	with	with	IN
cord-300872-blycbi4u	149	11	an	an	DT
cord-300872-blycbi4u	149	12	inhibition	inhibition	NN
cord-300872-blycbi4u	149	13	zone	zone	NN
cord-300872-blycbi4u	149	14	of	of	IN
cord-300872-blycbi4u	149	15	22	22	CD
cord-300872-blycbi4u	149	16	mm	mm	NNS
cord-300872-blycbi4u	149	17	compared	compare	VBN
cord-300872-blycbi4u	149	18	to	to	IN
cord-300872-blycbi4u	149	19	the	the	DT
cord-300872-blycbi4u	149	20	reference	reference	NN
cord-300872-blycbi4u	149	21	drug	drug	NN
cord-300872-blycbi4u	149	22	(	(	-LRB-
cord-300872-blycbi4u	149	23	24	24	CD
cord-300872-blycbi4u	149	24	mm	mm	NNP
cord-300872-blycbi4u	149	25	)	)	-RRB-
cord-300872-blycbi4u	149	26	.	.	.
cord-300872-blycbi4u	150	1	On	on	IN
cord-300872-blycbi4u	150	2	the	the	DT
cord-300872-blycbi4u	150	3	other	other	JJ
cord-300872-blycbi4u	150	4	hand	hand	NN
cord-300872-blycbi4u	150	5	,	,	,
cord-300872-blycbi4u	150	6	derivatives	derivative	NNS
cord-300872-blycbi4u	150	7	with	with	IN
cord-300872-blycbi4u	150	8	Ar	Ar	NNP
cord-300872-blycbi4u	150	9	=	=	SYM
cord-300872-blycbi4u	150	10	4-FPh	4-fph	CD
cord-300872-blycbi4u	150	11	and	and	CC
cord-300872-blycbi4u	150	12	2-OH-5-NO2Ph	2-oh-5-no2ph	CD
cord-300872-blycbi4u	150	13	displayed	display	VBD
cord-300872-blycbi4u	150	14	potent	potent	JJ
cord-300872-blycbi4u	150	15	activity	activity	NN
cord-300872-blycbi4u	150	16	against	against	IN
cord-300872-blycbi4u	150	17	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	150	18	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	150	19	,	,	,
cord-300872-blycbi4u	150	20	with	with	IN
cord-300872-blycbi4u	150	21	inhibition	inhibition	NN
cord-300872-blycbi4u	150	22	zones	zone	NNS
cord-300872-blycbi4u	150	23	of	of	IN
cord-300872-blycbi4u	150	24	22	22	CD
cord-300872-blycbi4u	150	25	mm	mm	NNS
cord-300872-blycbi4u	150	26	and	and	CC
cord-300872-blycbi4u	150	27	23	23	CD
cord-300872-blycbi4u	150	28	mm	mm	NNS
cord-300872-blycbi4u	150	29	,	,	,
cord-300872-blycbi4u	150	30	respectively	respectively	RB
cord-300872-blycbi4u	150	31	,	,	,
cord-300872-blycbi4u	150	32	compared	compare	VBN
cord-300872-blycbi4u	150	33	to	to	IN
cord-300872-blycbi4u	150	34	the	the	DT
cord-300872-blycbi4u	150	35	standard	standard	JJ
cord-300872-blycbi4u	150	36	drug	drug	NN
cord-300872-blycbi4u	150	37	(	(	-LRB-
cord-300872-blycbi4u	150	38	24	24	CD
cord-300872-blycbi4u	150	39	mm	mm	NNP
cord-300872-blycbi4u	150	40	)	)	-RRB-
cord-300872-blycbi4u	150	41	,	,	,
cord-300872-blycbi4u	150	42	whereas	whereas	IN
cord-300872-blycbi4u	150	43	the	the	DT
cord-300872-blycbi4u	150	44	derivative	derivative	NN
cord-300872-blycbi4u	150	45	with	with	IN
cord-300872-blycbi4u	150	46	R	r	NN
cord-300872-blycbi4u	150	47	=	=	NN
cord-300872-blycbi4u	150	48	4-CH3Ph	4-ch3ph	CD
cord-300872-blycbi4u	150	49	was	be	VBD
cord-300872-blycbi4u	150	50	potent	potent	JJ
cord-300872-blycbi4u	150	51	against	against	IN
cord-300872-blycbi4u	150	52	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	150	53	pneumonia	pneumonia	NN
cord-300872-blycbi4u	150	54	,	,	,
cord-300872-blycbi4u	150	55	with	with	IN
cord-300872-blycbi4u	150	56	an	an	DT
cord-300872-blycbi4u	150	57	inhibition	inhibition	NN
cord-300872-blycbi4u	150	58	zone	zone	NN
cord-300872-blycbi4u	150	59	of	of	IN
cord-300872-blycbi4u	150	60	25	25	CD
cord-300872-blycbi4u	150	61	mm	mm	NNS
cord-300872-blycbi4u	150	62	compared	compare	VBN
cord-300872-blycbi4u	150	63	to	to	IN
cord-300872-blycbi4u	150	64	the	the	DT
cord-300872-blycbi4u	150	65	standard	standard	JJ
cord-300872-blycbi4u	150	66	drug	drug	NN
cord-300872-blycbi4u	150	67	(	(	-LRB-
cord-300872-blycbi4u	150	68	27	27	CD
cord-300872-blycbi4u	150	69	mm	mm	NN
cord-300872-blycbi4u	150	70	)	)	-RRB-
cord-300872-blycbi4u	150	71	.	.	.
cord-300872-blycbi4u	151	1	A	a	DT
cord-300872-blycbi4u	151	2	study	study	NN
cord-300872-blycbi4u	151	3	published	publish	VBN
cord-300872-blycbi4u	151	4	by	by	IN
cord-300872-blycbi4u	151	5	Rbaa	Rbaa	NNP
cord-300872-blycbi4u	152	1	These	these	DT
cord-300872-blycbi4u	152	2	compounds	compound	NNS
cord-300872-blycbi4u	152	3	were	be	VBD
cord-300872-blycbi4u	152	4	tested	test	VBN
cord-300872-blycbi4u	152	5	as	as	IN
cord-300872-blycbi4u	152	6	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	152	7	agents	agent	NNS
cord-300872-blycbi4u	152	8	against	against	IN
cord-300872-blycbi4u	152	9	six	six	CD
cord-300872-blycbi4u	152	10	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	152	11	strains	strain	NNS
cord-300872-blycbi4u	152	12	,	,	,
cord-300872-blycbi4u	152	13	including	include	VBG
cord-300872-blycbi4u	152	14	E.	E.	NNP
cord-300872-blycbi4u	152	15	cloacae	cloacae	NN
cord-300872-blycbi4u	152	16	,	,	,
cord-300872-blycbi4u	152	17	E.	E.	NNP
cord-300872-blycbi4u	152	18	coli	coli	NNS
cord-300872-blycbi4u	152	19	,	,	,
cord-300872-blycbi4u	152	20	K.	K.	NNP
cord-300872-blycbi4u	152	21	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	152	22	,	,	,
cord-300872-blycbi4u	152	23	P.	P.	NNP
cord-300872-blycbi4u	152	24	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	152	25	,	,	,
cord-300872-blycbi4u	152	26	S.	S.	NNP
cord-300872-blycbi4u	152	27	aureus	aureus	NN
cord-300872-blycbi4u	152	28	,	,	,
cord-300872-blycbi4u	152	29	and	and	CC
cord-300872-blycbi4u	152	30	A.	a.	NN
cord-300872-blycbi4u	152	31	baumanii	baumanii	NN
cord-300872-blycbi4u	152	32	.	.	.
cord-300872-blycbi4u	153	1	Minimal	minimal	JJ
cord-300872-blycbi4u	153	2	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	153	3	concentrations	concentration	NNS
cord-300872-blycbi4u	153	4	of	of	IN
cord-300872-blycbi4u	153	5	these	these	DT
cord-300872-blycbi4u	153	6	compounds	compound	NNS
cord-300872-blycbi4u	153	7	were	be	VBD
cord-300872-blycbi4u	153	8	calculated	calculate	VBN
cord-300872-blycbi4u	153	9	and	and	CC
cord-300872-blycbi4u	153	10	compared	compare	VBN
cord-300872-blycbi4u	153	11	with	with	IN
cord-300872-blycbi4u	153	12	three	three	CD
cord-300872-blycbi4u	153	13	standard	standard	JJ
cord-300872-blycbi4u	153	14	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	153	15	,	,	,
cord-300872-blycbi4u	153	16	namely	namely	RB
cord-300872-blycbi4u	153	17	penicillin	penicillin	NN
cord-300872-blycbi4u	153	18	G	G	NNP
cord-300872-blycbi4u	153	19	,	,	,
cord-300872-blycbi4u	153	20	norfloxacin	norfloxacin	NNS
cord-300872-blycbi4u	153	21	,	,	,
cord-300872-blycbi4u	153	22	and	and	CC
cord-300872-blycbi4u	153	23	erythromycin	erythromycin	NN
cord-300872-blycbi4u	153	24	,	,	,
cord-300872-blycbi4u	153	25	using	use	VBG
cord-300872-blycbi4u	153	26	the	the	DT
cord-300872-blycbi4u	153	27	disk	disk	NN
cord-300872-blycbi4u	153	28	diffusion	diffusion	NN
cord-300872-blycbi4u	153	29	technique	technique	NN
cord-300872-blycbi4u	153	30	.	.	.
cord-300872-blycbi4u	154	1	Some	some	DT
cord-300872-blycbi4u	154	2	of	of	IN
cord-300872-blycbi4u	154	3	these	these	DT
cord-300872-blycbi4u	154	4	prepared	prepared	JJ
cord-300872-blycbi4u	154	5	compounds	compound	NNS
cord-300872-blycbi4u	154	6	exhibited	exhibit	VBD
cord-300872-blycbi4u	154	7	remarkable	remarkable	JJ
cord-300872-blycbi4u	154	8	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	154	9	activity	activity	NN
cord-300872-blycbi4u	154	10	against	against	IN
cord-300872-blycbi4u	154	11	Gram	gram	NN
cord-300872-blycbi4u	154	12	-	-	HYPH
cord-300872-blycbi4u	154	13	positive	positive	JJ
cord-300872-blycbi4u	154	14	and	and	CC
cord-300872-blycbi4u	154	15	Gramnegative	gramnegative	JJ
cord-300872-blycbi4u	154	16	strains	strain	NNS
cord-300872-blycbi4u	154	17	compared	compare	VBN
cord-300872-blycbi4u	154	18	to	to	IN
cord-300872-blycbi4u	154	19	the	the	DT
cord-300872-blycbi4u	154	20	standard	standard	JJ
cord-300872-blycbi4u	154	21	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	154	22	used	use	VBN
cord-300872-blycbi4u	154	23	.	.	.
cord-300872-blycbi4u	155	1	One	one	CD
cord-300872-blycbi4u	155	2	derivative	derivative	JJ
cord-300872-blycbi4u	155	3	(	(	-LRB-
cord-300872-blycbi4u	155	4	R	r	NN
cord-300872-blycbi4u	155	5	=	=	SYM
cord-300872-blycbi4u	155	6	NO2	NO2	NNP
cord-300872-blycbi4u	155	7	,	,	,
cord-300872-blycbi4u	155	8	R′	r′	NN
cord-300872-blycbi4u	155	9	=	=	SYM
cord-300872-blycbi4u	155	10	H	h	NN
cord-300872-blycbi4u	155	11	)	)	-RRB-
cord-300872-blycbi4u	155	12	was	be	VBD
cord-300872-blycbi4u	155	13	more	more	RBR
cord-300872-blycbi4u	155	14	potent	potent	JJ
cord-300872-blycbi4u	155	15	than	than	IN
cord-300872-blycbi4u	155	16	the	the	DT
cord-300872-blycbi4u	155	17	standard	standard	JJ
cord-300872-blycbi4u	155	18	drugs	drug	NNS
cord-300872-blycbi4u	155	19	and	and	CC
cord-300872-blycbi4u	155	20	showed	show	VBD
cord-300872-blycbi4u	155	21	activity	activity	NN
cord-300872-blycbi4u	155	22	against	against	IN
cord-300872-blycbi4u	155	23	E.	E.	NNP
cord-300872-blycbi4u	155	24	cloacae	cloacae	NNP
cord-300872-blycbi4u	155	25	,	,	,
cord-300872-blycbi4u	155	26	K.	K.	NNP
cord-300872-blycbi4u	155	27	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	155	28	,	,	,
cord-300872-blycbi4u	155	29	S.	S.	NNP
cord-300872-blycbi4u	155	30	aureus	aureus	NN
cord-300872-blycbi4u	155	31	,	,	,
cord-300872-blycbi4u	155	32	These	these	DT
cord-300872-blycbi4u	155	33	compounds	compound	NNS
cord-300872-blycbi4u	155	34	were	be	VBD
cord-300872-blycbi4u	155	35	tested	test	VBN
cord-300872-blycbi4u	155	36	as	as	IN
cord-300872-blycbi4u	155	37	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	155	38	agents	agent	NNS
cord-300872-blycbi4u	155	39	against	against	IN
cord-300872-blycbi4u	155	40	six	six	CD
cord-300872-blycbi4u	155	41	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	155	42	strains	strain	NNS
cord-300872-blycbi4u	155	43	,	,	,
cord-300872-blycbi4u	155	44	including	include	VBG
cord-300872-blycbi4u	155	45	E.	E.	NNP
cord-300872-blycbi4u	155	46	cloacae	cloacae	NN
cord-300872-blycbi4u	155	47	,	,	,
cord-300872-blycbi4u	155	48	E.	E.	NNP
cord-300872-blycbi4u	155	49	coli	coli	NNS
cord-300872-blycbi4u	155	50	,	,	,
cord-300872-blycbi4u	155	51	K.	K.	NNP
cord-300872-blycbi4u	155	52	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	155	53	,	,	,
cord-300872-blycbi4u	155	54	P.	P.	NNP
cord-300872-blycbi4u	155	55	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	155	56	,	,	,
cord-300872-blycbi4u	155	57	S.	S.	NNP
cord-300872-blycbi4u	155	58	aureus	aureus	NN
cord-300872-blycbi4u	155	59	,	,	,
cord-300872-blycbi4u	155	60	and	and	CC
cord-300872-blycbi4u	155	61	A.	a.	NN
cord-300872-blycbi4u	155	62	baumanii	baumanii	NN
cord-300872-blycbi4u	155	63	.	.	.
cord-300872-blycbi4u	156	1	Minimal	minimal	JJ
cord-300872-blycbi4u	156	2	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	156	3	concentrations	concentration	NNS
cord-300872-blycbi4u	156	4	of	of	IN
cord-300872-blycbi4u	156	5	these	these	DT
cord-300872-blycbi4u	156	6	compounds	compound	NNS
cord-300872-blycbi4u	156	7	were	be	VBD
cord-300872-blycbi4u	156	8	calculated	calculate	VBN
cord-300872-blycbi4u	156	9	and	and	CC
cord-300872-blycbi4u	156	10	compared	compare	VBN
cord-300872-blycbi4u	156	11	with	with	IN
cord-300872-blycbi4u	156	12	three	three	CD
cord-300872-blycbi4u	156	13	standard	standard	JJ
cord-300872-blycbi4u	156	14	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	156	15	,	,	,
cord-300872-blycbi4u	156	16	namely	namely	RB
cord-300872-blycbi4u	156	17	penicillin	penicillin	NN
cord-300872-blycbi4u	156	18	G	G	NNP
cord-300872-blycbi4u	156	19	,	,	,
cord-300872-blycbi4u	156	20	norfloxacin	norfloxacin	NNS
cord-300872-blycbi4u	156	21	,	,	,
cord-300872-blycbi4u	156	22	and	and	CC
cord-300872-blycbi4u	156	23	erythromycin	erythromycin	NN
cord-300872-blycbi4u	156	24	,	,	,
cord-300872-blycbi4u	156	25	using	use	VBG
cord-300872-blycbi4u	156	26	the	the	DT
cord-300872-blycbi4u	156	27	disk	disk	NN
cord-300872-blycbi4u	156	28	diffusion	diffusion	NN
cord-300872-blycbi4u	156	29	technique	technique	NN
cord-300872-blycbi4u	156	30	.	.	.
cord-300872-blycbi4u	157	1	Some	some	DT
cord-300872-blycbi4u	157	2	of	of	IN
cord-300872-blycbi4u	157	3	these	these	DT
cord-300872-blycbi4u	157	4	prepared	prepared	JJ
cord-300872-blycbi4u	157	5	compounds	compound	NNS
cord-300872-blycbi4u	157	6	exhibited	exhibit	VBD
cord-300872-blycbi4u	157	7	remarkable	remarkable	JJ
cord-300872-blycbi4u	157	8	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	157	9	activity	activity	NN
cord-300872-blycbi4u	157	10	against	against	IN
cord-300872-blycbi4u	157	11	Gram	gram	NN
cord-300872-blycbi4u	157	12	-	-	HYPH
cord-300872-blycbi4u	157	13	positive	positive	JJ
cord-300872-blycbi4u	157	14	and	and	CC
cord-300872-blycbi4u	157	15	Gram	gram	NN
cord-300872-blycbi4u	157	16	-	-	HYPH
cord-300872-blycbi4u	157	17	negative	negative	JJ
cord-300872-blycbi4u	157	18	strains	strain	NNS
cord-300872-blycbi4u	157	19	compared	compare	VBN
cord-300872-blycbi4u	157	20	to	to	IN
cord-300872-blycbi4u	157	21	the	the	DT
cord-300872-blycbi4u	157	22	standard	standard	JJ
cord-300872-blycbi4u	157	23	antibiotics	antibiotic	NNS
cord-300872-blycbi4u	157	24	used	use	VBN
cord-300872-blycbi4u	157	25	.	.	.
cord-300872-blycbi4u	158	1	One	one	CD
cord-300872-blycbi4u	158	2	derivative	derivative	JJ
cord-300872-blycbi4u	158	3	(	(	-LRB-
cord-300872-blycbi4u	158	4	R	r	NN
cord-300872-blycbi4u	158	5	=	=	NN
cord-300872-blycbi4u	158	6	NO	no	DT
cord-300872-blycbi4u	158	7	2	2	CD
cord-300872-blycbi4u	158	8	,	,	,
cord-300872-blycbi4u	158	9	R	r	NN
cord-300872-blycbi4u	158	10	=	=	NN
cord-300872-blycbi4u	158	11	H	h	NN
cord-300872-blycbi4u	158	12	)	)	-RRB-
cord-300872-blycbi4u	158	13	was	be	VBD
cord-300872-blycbi4u	158	14	more	more	RBR
cord-300872-blycbi4u	158	15	potent	potent	JJ
cord-300872-blycbi4u	158	16	than	than	IN
cord-300872-blycbi4u	158	17	the	the	DT
cord-300872-blycbi4u	158	18	standard	standard	JJ
cord-300872-blycbi4u	158	19	drugs	drug	NNS
cord-300872-blycbi4u	158	20	and	and	CC
cord-300872-blycbi4u	158	21	showed	show	VBD
cord-300872-blycbi4u	158	22	activity	activity	NN
cord-300872-blycbi4u	158	23	against	against	IN
cord-300872-blycbi4u	158	24	E.	E.	NNP
cord-300872-blycbi4u	158	25	cloacae	cloacae	NNP
cord-300872-blycbi4u	158	26	,	,	,
cord-300872-blycbi4u	158	27	K.	K.	NNP
cord-300872-blycbi4u	158	28	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	158	29	,	,	,
cord-300872-blycbi4u	158	30	S.	S.	NNP
cord-300872-blycbi4u	158	31	aureus	aureus	NN
cord-300872-blycbi4u	158	32	,	,	,
cord-300872-blycbi4u	158	33	A.	a.	NN
cord-300872-blycbi4u	158	34	baumanii	baumanii	NN
cord-300872-blycbi4u	158	35	,	,	,
cord-300872-blycbi4u	158	36	E.	E.	NNP
cord-300872-blycbi4u	158	37	coli	coli	NNS
cord-300872-blycbi4u	158	38	,	,	,
cord-300872-blycbi4u	158	39	E.	E.	NNP
cord-300872-blycbi4u	158	40	cloacae	cloacae	NN
cord-300872-blycbi4u	158	41	,	,	,
cord-300872-blycbi4u	158	42	and	and	CC
cord-300872-blycbi4u	158	43	E.	E.	NNP
cord-300872-blycbi4u	158	44	cloaca	cloaca	NN
cord-300872-blycbi4u	158	45	,	,	,
cord-300872-blycbi4u	158	46	with	with	IN
cord-300872-blycbi4u	158	47	minimum	minimum	JJ
cord-300872-blycbi4u	158	48	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	158	49	concentration	concentration	NN
cord-300872-blycbi4u	158	50	(	(	-LRB-
cord-300872-blycbi4u	158	51	MIC	mic	NN
cord-300872-blycbi4u	158	52	)	)	-RRB-
cord-300872-blycbi4u	158	53	values	value	NNS
cord-300872-blycbi4u	158	54	(	(	-LRB-
cord-300872-blycbi4u	158	55	mg	mg	NNP
cord-300872-blycbi4u	158	56	/	/	SYM
cord-300872-blycbi4u	158	57	mL	mL	NNP
cord-300872-blycbi4u	158	58	)	)	-RRB-
cord-300872-blycbi4u	158	59	of	of	IN
cord-300872-blycbi4u	158	60	1	1	CD
cord-300872-blycbi4u	158	61	×	×	CD
cord-300872-blycbi4u	158	62	10	10	CD
cord-300872-blycbi4u	158	63	−6	−6	NNS
cord-300872-blycbi4u	158	64	,	,	,
cord-300872-blycbi4u	158	65	1	1	CD
cord-300872-blycbi4u	158	66	×	×	NN
cord-300872-blycbi4u	158	67	10	10	CD
cord-300872-blycbi4u	158	68	−5	−5	NNS
cord-300872-blycbi4u	158	69	,	,	,
cord-300872-blycbi4u	158	70	1	1	CD
cord-300872-blycbi4u	158	71	×	×	NN
cord-300872-blycbi4u	158	72	10	10	CD
cord-300872-blycbi4u	158	73	−5	−5	NNS
cord-300872-blycbi4u	158	74	,	,	,
cord-300872-blycbi4u	158	75	1	1	CD
cord-300872-blycbi4u	158	76	×	×	NN
cord-300872-blycbi4u	158	77	10	10	CD
cord-300872-blycbi4u	158	78	−4	−4	CD
cord-300872-blycbi4u	158	79	,	,	,
cord-300872-blycbi4u	158	80	and	and	CC
cord-300872-blycbi4u	158	81	1	1	CD
cord-300872-blycbi4u	158	82	×	×	NN
cord-300872-blycbi4u	158	83	10	10	CD
cord-300872-blycbi4u	158	84	−4	−4	CD
cord-300872-blycbi4u	158	85	,	,	,
cord-300872-blycbi4u	158	86	respectively	respectively	RB
cord-300872-blycbi4u	158	87	,	,	,
cord-300872-blycbi4u	158	88	while	while	IN
cord-300872-blycbi4u	158	89	the	the	DT
cord-300872-blycbi4u	158	90	MIC	MIC	NNP
cord-300872-blycbi4u	158	91	for	for	IN
cord-300872-blycbi4u	158	92	the	the	DT
cord-300872-blycbi4u	158	93	standard	standard	JJ
cord-300872-blycbi4u	158	94	drug	drug	NN
cord-300872-blycbi4u	158	95	was	be	VBD
cord-300872-blycbi4u	158	96	1	1	CD
cord-300872-blycbi4u	158	97	×	×	NN
cord-300872-blycbi4u	158	98	10	10	CD
cord-300872-blycbi4u	158	99	−4	−4	CD
cord-300872-blycbi4u	158	100	.	.	.
cord-300872-blycbi4u	159	1	Derivatives	derivative	NNS
cord-300872-blycbi4u	159	2	with	with	IN
cord-300872-blycbi4u	159	3	R	r	NN
cord-300872-blycbi4u	159	4	=	=	SYM
cord-300872-blycbi4u	159	5	R	r	NN
cord-300872-blycbi4u	159	6	=	=	SYM
cord-300872-blycbi4u	159	7	H	h	NN
cord-300872-blycbi4u	159	8	and	and	CC
cord-300872-blycbi4u	159	9	R	r	NN
cord-300872-blycbi4u	159	10	=	=	SYM
cord-300872-blycbi4u	159	11	H	h	NN
cord-300872-blycbi4u	159	12	,	,	,
cord-300872-blycbi4u	159	13	R	r	NN
cord-300872-blycbi4u	159	14	=	=	NN
cord-300872-blycbi4u	160	1	Cl	Cl	NNP
cord-300872-blycbi4u	160	2	displayed	display	VBD
cord-300872-blycbi4u	160	3	similar	similar	JJ
cord-300872-blycbi4u	160	4	activities	activity	NNS
cord-300872-blycbi4u	160	5	against	against	IN
cord-300872-blycbi4u	160	6	S.	S.	NNP
cord-300872-blycbi4u	160	7	aureus	aureus	NN
cord-300872-blycbi4u	160	8	,	,	,
cord-300872-blycbi4u	160	9	with	with	IN
cord-300872-blycbi4u	160	10	MIC	mic	NN
cord-300872-blycbi4u	160	11	values	value	NNS
cord-300872-blycbi4u	160	12	of	of	IN
cord-300872-blycbi4u	160	13	1	1	CD
cord-300872-blycbi4u	160	14	×	×	NN
cord-300872-blycbi4u	160	15	10	10	CD
cord-300872-blycbi4u	160	16	−4	−4	CD
cord-300872-blycbi4u	160	17	.	.	.
cord-300872-blycbi4u	161	1	Bioinformatic	Bioinformatic	NNP
cord-300872-blycbi4u	161	2	petra	petra	NNP
cord-300872-blycbi4u	161	3	,	,	,
cord-300872-blycbi4u	161	4	osiris	osiris	NNP
cord-300872-blycbi4u	161	5	,	,	,
cord-300872-blycbi4u	161	6	and	and	CC
cord-300872-blycbi4u	161	7	molinspiration	molinspiration	NN
cord-300872-blycbi4u	161	8	(	(	-LRB-
cord-300872-blycbi4u	161	9	POM	pom	NN
cord-300872-blycbi4u	161	10	)	)	-RRB-
cord-300872-blycbi4u	161	11	analyses	analysis	NNS
cord-300872-blycbi4u	161	12	indicated	indicate	VBD
cord-300872-blycbi4u	161	13	that	that	IN
cord-300872-blycbi4u	161	14	all	all	DT
cord-300872-blycbi4u	161	15	compounds	compound	NNS
cord-300872-blycbi4u	161	16	exhibit	exhibit	VBP
cord-300872-blycbi4u	161	17	good	good	JJ
cord-300872-blycbi4u	161	18	bioavailability	bioavailability	NN
cord-300872-blycbi4u	161	19	and	and	CC
cord-300872-blycbi4u	161	20	less	less	RBR
cord-300872-blycbi4u	161	21	toxic	toxic	JJ
cord-300872-blycbi4u	161	22	profiles	profile	NNS
cord-300872-blycbi4u	161	23	when	when	WRB
cord-300872-blycbi4u	161	24	compared	compare	VBN
cord-300872-blycbi4u	161	25	with	with	IN
cord-300872-blycbi4u	162	1	penicillin	penicillin	NN
cord-300872-blycbi4u	162	2	G.	G.	NNP
cord-300872-blycbi4u	162	3	Interestingly	interestingly	RB
cord-300872-blycbi4u	162	4	,	,	,
cord-300872-blycbi4u	162	5	two	two	CD
cord-300872-blycbi4u	162	6	research	research	NN
cord-300872-blycbi4u	162	7	groups	group	NNS
cord-300872-blycbi4u	162	8	have	have	VBP
cord-300872-blycbi4u	162	9	reported	report	VBN
cord-300872-blycbi4u	162	10	on	on	IN
cord-300872-blycbi4u	162	11	the	the	DT
cord-300872-blycbi4u	162	12	hybridization	hybridization	NN
cord-300872-blycbi4u	162	13	of	of	IN
cord-300872-blycbi4u	162	14	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	162	15	with	with	IN
cord-300872-blycbi4u	162	16	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	162	17	in	in	IN
cord-300872-blycbi4u	162	18	a	a	DT
cord-300872-blycbi4u	162	19	single	single	JJ
cord-300872-blycbi4u	162	20	step	step	NN
cord-300872-blycbi4u	162	21	and	and	CC
cord-300872-blycbi4u	162	22	evaluated	evaluate	VBD
cord-300872-blycbi4u	162	23	the	the	DT
cord-300872-blycbi4u	162	24	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	162	25	activity	activity	NN
cord-300872-blycbi4u	162	26	of	of	IN
cord-300872-blycbi4u	162	27	the	the	DT
cord-300872-blycbi4u	162	28	hybrid	hybrid	JJ
cord-300872-blycbi4u	162	29	molecule	molecule	NN
cord-300872-blycbi4u	162	30	.	.	.
cord-300872-blycbi4u	163	1	Fu	Fu	NNP
cord-300872-blycbi4u	163	2	et	et	FW
cord-300872-blycbi4u	163	3	al	al	NNP
cord-300872-blycbi4u	163	4	.	.	NNP
cord-300872-blycbi4u	163	5	reported	report	VBD
cord-300872-blycbi4u	163	6	the	the	DT
cord-300872-blycbi4u	163	7	synthesis	synthesis	NN
cord-300872-blycbi4u	163	8	of	of	IN
cord-300872-blycbi4u	163	9	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	163	10	-	-	HYPH
cord-300872-blycbi4u	163	11	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	163	12	19	19	CD
cord-300872-blycbi4u	163	13	via	via	IN
cord-300872-blycbi4u	163	14	the	the	DT
cord-300872-blycbi4u	163	15	Mannich	Mannich	NNP
cord-300872-blycbi4u	163	16	reaction	reaction	NN
cord-300872-blycbi4u	163	17	(	(	-LRB-
cord-300872-blycbi4u	163	18	Scheme	scheme	NN
cord-300872-blycbi4u	163	19	6	6	CD
cord-300872-blycbi4u	163	20	)	)	-RRB-
cord-300872-blycbi4u	163	21	.	.	.
cord-300872-blycbi4u	164	1	Thus	thus	RB
cord-300872-blycbi4u	164	2	,	,	,
cord-300872-blycbi4u	164	3	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	164	4	18	18	CD
cord-300872-blycbi4u	164	5	reacted	react	VBD
cord-300872-blycbi4u	164	6	with	with	IN
cord-300872-blycbi4u	164	7	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	164	8	in	in	IN
cord-300872-blycbi4u	164	9	the	the	DT
cord-300872-blycbi4u	164	10	presence	presence	NN
cord-300872-blycbi4u	164	11	of	of	IN
cord-300872-blycbi4u	164	12	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	164	13	in	in	IN
cord-300872-blycbi4u	164	14	ethanol	ethanol	NN
cord-300872-blycbi4u	164	15	to	to	TO
cord-300872-blycbi4u	164	16	afford	afford	VB
cord-300872-blycbi4u	164	17	the	the	DT
cord-300872-blycbi4u	164	18	hybrid	hybrid	JJ
cord-300872-blycbi4u	164	19	product	product	NN
cord-300872-blycbi4u	164	20	at	at	IN
cord-300872-blycbi4u	164	21	75	75	CD
cord-300872-blycbi4u	164	22	%	%	NN
cord-300872-blycbi4u	164	23	yield	yield	NN
cord-300872-blycbi4u	164	24	[	[	-LRB-
cord-300872-blycbi4u	164	25	12	12	CD
cord-300872-blycbi4u	164	26	]	]	-RRB-
cord-300872-blycbi4u	164	27	.	.	.
cord-300872-blycbi4u	165	1	Interestingly	interestingly	RB
cord-300872-blycbi4u	165	2	,	,	,
cord-300872-blycbi4u	165	3	two	two	CD
cord-300872-blycbi4u	165	4	research	research	NN
cord-300872-blycbi4u	165	5	groups	group	NNS
cord-300872-blycbi4u	165	6	have	have	VBP
cord-300872-blycbi4u	165	7	reported	report	VBN
cord-300872-blycbi4u	165	8	on	on	IN
cord-300872-blycbi4u	165	9	the	the	DT
cord-300872-blycbi4u	165	10	hybridization	hybridization	NN
cord-300872-blycbi4u	165	11	of	of	IN
cord-300872-blycbi4u	165	12	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	165	13	with	with	IN
cord-300872-blycbi4u	165	14	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	165	15	in	in	IN
cord-300872-blycbi4u	165	16	a	a	DT
cord-300872-blycbi4u	165	17	single	single	JJ
cord-300872-blycbi4u	165	18	step	step	NN
cord-300872-blycbi4u	165	19	and	and	CC
cord-300872-blycbi4u	165	20	evaluated	evaluate	VBD
cord-300872-blycbi4u	165	21	the	the	DT
cord-300872-blycbi4u	165	22	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	165	23	activity	activity	NN
cord-300872-blycbi4u	165	24	of	of	IN
cord-300872-blycbi4u	165	25	the	the	DT
cord-300872-blycbi4u	165	26	hybrid	hybrid	JJ
cord-300872-blycbi4u	165	27	molecule	molecule	NN
cord-300872-blycbi4u	165	28	.	.	.
cord-300872-blycbi4u	166	1	Fu	Fu	NNP
cord-300872-blycbi4u	166	2	et	et	FW
cord-300872-blycbi4u	166	3	al	al	NNP
cord-300872-blycbi4u	166	4	.	.	NNP
cord-300872-blycbi4u	166	5	reported	report	VBD
cord-300872-blycbi4u	166	6	the	the	DT
cord-300872-blycbi4u	166	7	synthesis	synthesis	NN
cord-300872-blycbi4u	166	8	of	of	IN
cord-300872-blycbi4u	166	9	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	166	10	-	-	HYPH
cord-300872-blycbi4u	166	11	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	166	12	19	19	CD
cord-300872-blycbi4u	166	13	via	via	IN
cord-300872-blycbi4u	166	14	the	the	DT
cord-300872-blycbi4u	166	15	Mannich	Mannich	NNP
cord-300872-blycbi4u	166	16	reaction	reaction	NN
cord-300872-blycbi4u	166	17	(	(	-LRB-
cord-300872-blycbi4u	166	18	Scheme	scheme	NN
cord-300872-blycbi4u	166	19	6	6	CD
cord-300872-blycbi4u	166	20	)	)	-RRB-
cord-300872-blycbi4u	166	21	.	.	.
cord-300872-blycbi4u	167	1	Thus	thus	RB
cord-300872-blycbi4u	167	2	,	,	,
cord-300872-blycbi4u	167	3	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	167	4	18	18	CD
cord-300872-blycbi4u	167	5	reacted	react	VBD
cord-300872-blycbi4u	167	6	with	with	IN
cord-300872-blycbi4u	167	7	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	167	8	in	in	IN
cord-300872-blycbi4u	167	9	the	the	DT
cord-300872-blycbi4u	167	10	presence	presence	NN
cord-300872-blycbi4u	167	11	of	of	IN
cord-300872-blycbi4u	167	12	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	167	13	in	in	IN
cord-300872-blycbi4u	167	14	ethanol	ethanol	NN
cord-300872-blycbi4u	167	15	to	to	TO
cord-300872-blycbi4u	167	16	afford	afford	VB
cord-300872-blycbi4u	167	17	the	the	DT
cord-300872-blycbi4u	167	18	hybrid	hybrid	JJ
cord-300872-blycbi4u	167	19	product	product	NN
cord-300872-blycbi4u	167	20	at	at	IN
cord-300872-blycbi4u	167	21	75	75	CD
cord-300872-blycbi4u	167	22	%	%	NN
cord-300872-blycbi4u	167	23	yield	yield	NN
cord-300872-blycbi4u	167	24	[	[	-LRB-
cord-300872-blycbi4u	167	25	12	12	CD
cord-300872-blycbi4u	167	26	]	]	-RRB-
cord-300872-blycbi4u	167	27	.	.	.
cord-300872-blycbi4u	168	1	The	the	DT
cord-300872-blycbi4u	168	2	hybrid	hybrid	JJ
cord-300872-blycbi4u	168	3	19	19	CD
cord-300872-blycbi4u	168	4	was	be	VBD
cord-300872-blycbi4u	168	5	screened	screen	VBN
cord-300872-blycbi4u	168	6	against	against	IN
cord-300872-blycbi4u	168	7	both	both	DT
cord-300872-blycbi4u	168	8	Gram	gram	NN
cord-300872-blycbi4u	168	9	-	-	HYPH
cord-300872-blycbi4u	168	10	positive	positive	JJ
cord-300872-blycbi4u	168	11	and	and	CC
cord-300872-blycbi4u	168	12	Gram	gram	NN
cord-300872-blycbi4u	168	13	-	-	HYPH
cord-300872-blycbi4u	168	14	negative	negative	JJ
cord-300872-blycbi4u	168	15	(	(	-LRB-
cord-300872-blycbi4u	168	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	168	17	epidermidis	epidermidi	NNS
cord-300872-blycbi4u	168	18	,	,	,
cord-300872-blycbi4u	168	19	S.	S.	NNP
cord-300872-blycbi4u	168	20	aureus	aureus	NN
cord-300872-blycbi4u	168	21	,	,	,
cord-300872-blycbi4u	168	22	Enterococci	Enterococci	NNP
cord-300872-blycbi4u	168	23	faecalis	faecalis	NNP
cord-300872-blycbi4u	168	24	,	,	,
cord-300872-blycbi4u	168	25	and	and	CC
cord-300872-blycbi4u	168	26	E.	E.	NNP
cord-300872-blycbi4u	168	27	faecium	faecium	NN
cord-300872-blycbi4u	168	28	)	)	-RRB-
cord-300872-blycbi4u	169	1	bacterial	bacterial	JJ
cord-300872-blycbi4u	169	2	strains	strain	NNS
cord-300872-blycbi4u	169	3	,	,	,
cord-300872-blycbi4u	169	4	and	and	CC
cord-300872-blycbi4u	169	5	the	the	DT
cord-300872-blycbi4u	169	6	minimum	minimum	JJ
cord-300872-blycbi4u	169	7	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	169	8	concentrations	concentration	NNS
cord-300872-blycbi4u	169	9	(	(	-LRB-
cord-300872-blycbi4u	169	10	MICs	mic	NNS
cord-300872-blycbi4u	169	11	)	)	-RRB-
cord-300872-blycbi4u	169	12	were	be	VBD
cord-300872-blycbi4u	169	13	determined	determine	VBN
cord-300872-blycbi4u	169	14	via	via	IN
cord-300872-blycbi4u	169	15	the	the	DT
cord-300872-blycbi4u	169	16	agar	agar	NNP
cord-300872-blycbi4u	169	17	dilution	dilution	NN
cord-300872-blycbi4u	169	18	method	method	NN
cord-300872-blycbi4u	169	19	.	.	.
cord-300872-blycbi4u	170	1	The	the	DT
cord-300872-blycbi4u	170	2	results	result	NNS
cord-300872-blycbi4u	170	3	indicated	indicate	VBD
cord-300872-blycbi4u	170	4	that	that	IN
cord-300872-blycbi4u	170	5	the	the	DT
cord-300872-blycbi4u	170	6	hybrid	hybrid	NN
cord-300872-blycbi4u	170	7	shows	show	VBZ
cord-300872-blycbi4u	170	8	exciting	exciting	JJ
cord-300872-blycbi4u	170	9	promise	promise	NN
cord-300872-blycbi4u	170	10	against	against	IN
cord-300872-blycbi4u	170	11	both	both	CC
cord-300872-blycbi4u	170	12	Gram	gram	NN
cord-300872-blycbi4u	170	13	-	-	HYPH
cord-300872-blycbi4u	170	14	positive	positive	JJ
cord-300872-blycbi4u	170	15	and	and	CC
cord-300872-blycbi4u	170	16	Gram	gram	NN
cord-300872-blycbi4u	170	17	-	-	HYPH
cord-300872-blycbi4u	170	18	negative	negative	JJ
cord-300872-blycbi4u	170	19	bacteria	bacteria	NNS
cord-300872-blycbi4u	170	20	.	.	.
cord-300872-blycbi4u	171	1	It	-PRON-	PRP
cord-300872-blycbi4u	171	2	displayed	display	VBD
cord-300872-blycbi4u	171	3	significant	significant	JJ
cord-300872-blycbi4u	171	4	effects	effect	NNS
cord-300872-blycbi4u	171	5	against	against	IN
cord-300872-blycbi4u	171	6	both	both	CC
cord-300872-blycbi4u	171	7	susceptible	susceptible	JJ
cord-300872-blycbi4u	171	8	and	and	CC
cord-300872-blycbi4u	171	9	drug	drug	NN
cord-300872-blycbi4u	171	10	-	-	HYPH
cord-300872-blycbi4u	171	11	resistant	resistant	JJ
cord-300872-blycbi4u	171	12	strains	strain	NNS
cord-300872-blycbi4u	171	13	,	,	,
cord-300872-blycbi4u	171	14	with	with	IN
cord-300872-blycbi4u	171	15	MIC	mic	NN
cord-300872-blycbi4u	171	16	values	value	NNS
cord-300872-blycbi4u	171	17	of	of	IN
cord-300872-blycbi4u	171	18	4	4	CD
cord-300872-blycbi4u	171	19	-	-	SYM
cord-300872-blycbi4u	171	20	16	16	CD
cord-300872-blycbi4u	171	21	µg	µg	NN
cord-300872-blycbi4u	171	22	/	/	SYM
cord-300872-blycbi4u	171	23	mL.	ml.	NN
cord-300872-blycbi4u	171	24	These	these	DT
cord-300872-blycbi4u	171	25	values	value	NNS
cord-300872-blycbi4u	171	26	were	be	VBD
cord-300872-blycbi4u	171	27	lower	low	JJR
cord-300872-blycbi4u	171	28	than	than	IN
cord-300872-blycbi4u	171	29	those	those	DT
cord-300872-blycbi4u	171	30	of	of	IN
cord-300872-blycbi4u	171	31	standard	standard	JJ
cord-300872-blycbi4u	171	32	drug	drug	NN
cord-300872-blycbi4u	171	33	(	(	-LRB-
cord-300872-blycbi4u	171	34	ciprofloxacin	ciprofloxacin	NNP
cord-300872-blycbi4u	171	35	)	)	-RRB-
cord-300872-blycbi4u	171	36	,	,	,
cord-300872-blycbi4u	171	37	which	which	WDT
cord-300872-blycbi4u	171	38	has	have	VBZ
cord-300872-blycbi4u	171	39	MIC	mic	NN
cord-300872-blycbi4u	171	40	values	value	NNS
cord-300872-blycbi4u	171	41	of	of	IN
cord-300872-blycbi4u	171	42	0.125	0.125	CD
cord-300872-blycbi4u	171	43	-	-	SYM
cord-300872-blycbi4u	171	44	0.5	0.5	CD
cord-300872-blycbi4u	171	45	µg	µg	NN
cord-300872-blycbi4u	171	46	/	/	SYM
cord-300872-blycbi4u	171	47	mL.	mL.	NNS
cord-300872-blycbi4u	172	1	However	however	RB
cord-300872-blycbi4u	172	2	,	,	,
cord-300872-blycbi4u	172	3	the	the	DT
cord-300872-blycbi4u	172	4	authors	author	NNS
cord-300872-blycbi4u	172	5	speculated	speculate	VBD
cord-300872-blycbi4u	172	6	that	that	IN
cord-300872-blycbi4u	172	7	the	the	DT
cord-300872-blycbi4u	172	8	introduction	introduction	NN
cord-300872-blycbi4u	172	9	of	of	IN
cord-300872-blycbi4u	172	10	a	a	DT
cord-300872-blycbi4u	172	11	quinolone	quinolone	NNP
cord-300872-blycbi4u	172	12	skeleton	skeleton	NN
cord-300872-blycbi4u	172	13	might	may	MD
cord-300872-blycbi4u	172	14	be	be	VB
cord-300872-blycbi4u	172	15	an	an	DT
cord-300872-blycbi4u	172	16	effective	effective	JJ
cord-300872-blycbi4u	172	17	way	way	NN
cord-300872-blycbi4u	172	18	to	to	TO
cord-300872-blycbi4u	172	19	modify	modify	VB
cord-300872-blycbi4u	172	20	these	these	DT
cord-300872-blycbi4u	172	21	kinds	kind	NNS
cord-300872-blycbi4u	172	22	of	of	IN
cord-300872-blycbi4u	172	23	compounds	compound	NNS
cord-300872-blycbi4u	172	24	into	into	IN
cord-300872-blycbi4u	172	25	a	a	DT
cord-300872-blycbi4u	172	26	novel	novel	JJ
cord-300872-blycbi4u	172	27	class	class	NN
cord-300872-blycbi4u	172	28	of	of	IN
cord-300872-blycbi4u	172	29	broad	broad	JJ
cord-300872-blycbi4u	172	30	-	-	HYPH
cord-300872-blycbi4u	172	31	spectrum	spectrum	NN
cord-300872-blycbi4u	172	32	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	172	33	agents	agent	NNS
cord-300872-blycbi4u	172	34	with	with	IN
cord-300872-blycbi4u	172	35	a	a	DT
cord-300872-blycbi4u	172	36	specific	specific	JJ
cord-300872-blycbi4u	172	37	mode	mode	NN
cord-300872-blycbi4u	172	38	of	of	IN
cord-300872-blycbi4u	172	39	action	action	NN
cord-300872-blycbi4u	172	40	.	.	.
cord-300872-blycbi4u	173	1	On	on	IN
cord-300872-blycbi4u	173	2	the	the	DT
cord-300872-blycbi4u	173	3	other	other	JJ
cord-300872-blycbi4u	173	4	hand	hand	NN
cord-300872-blycbi4u	173	5	,	,	,
cord-300872-blycbi4u	173	6	Vu	Vu	NNP
cord-300872-blycbi4u	173	7	and	and	CC
cord-300872-blycbi4u	173	8	coworkers	coworker	NNS
cord-300872-blycbi4u	173	9	prepared	prepare	VBD
cord-300872-blycbi4u	173	10	a	a	DT
cord-300872-blycbi4u	173	11	hybrid	hybrid	JJ
cord-300872-blycbi4u	173	12	compound	compound	NN
cord-300872-blycbi4u	173	13	21	21	CD
cord-300872-blycbi4u	173	14	at	at	IN
cord-300872-blycbi4u	173	15	96	96	CD
cord-300872-blycbi4u	173	16	%	%	NN
cord-300872-blycbi4u	173	17	yield	yield	NN
cord-300872-blycbi4u	173	18	through	through	IN
cord-300872-blycbi4u	173	19	coupling	coupling	NN
cord-300872-blycbi4u	173	20	of	of	IN
cord-300872-blycbi4u	173	21	8-hydroxyquinoline-2-carboxylic	8-hydroxyquinoline-2-carboxylic	CD
cord-300872-blycbi4u	173	22	acid	acid	NN
cord-300872-blycbi4u	173	23	20	20	CD
cord-300872-blycbi4u	173	24	and	and	CC
cord-300872-blycbi4u	173	25	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	173	26	by	by	IN
cord-300872-blycbi4u	173	27	using	use	VBG
cord-300872-blycbi4u	173	28	2-(1H	2-(1h	CD
cord-300872-blycbi4u	173	29	-	-	HYPH
cord-300872-blycbi4u	173	30	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	NN
cord-300872-blycbi4u	173	31	tetrafluoroborate	tetrafluoroborate	NN
cord-300872-blycbi4u	173	32	(	(	-LRB-
cord-300872-blycbi4u	173	33	TBTU	TBTU	NNP
cord-300872-blycbi4u	173	34	)	)	-RRB-
cord-300872-blycbi4u	174	1	and	and	CC
cord-300872-blycbi4u	174	2	N	N	NNP
cord-300872-blycbi4u	174	3	,	,	,
cord-300872-blycbi4u	174	4	N	N	NNP
cord-300872-blycbi4u	174	5	-	-	HYPH
cord-300872-blycbi4u	174	6	diisopropylethylamine	diisopropylethylamine	NNP
cord-300872-blycbi4u	174	7	(	(	-LRB-
cord-300872-blycbi4u	174	8	DIEA	diea	NN
cord-300872-blycbi4u	174	9	)	)	-RRB-
cord-300872-blycbi4u	174	10	(	(	-LRB-
cord-300872-blycbi4u	174	11	Scheme	scheme	NN
cord-300872-blycbi4u	174	12	7	7	CD
cord-300872-blycbi4u	174	13	)	)	-RRB-
cord-300872-blycbi4u	174	14	[	[	-LRB-
cord-300872-blycbi4u	174	15	13	13	CD
cord-300872-blycbi4u	174	16	]	]	-RRB-
cord-300872-blycbi4u	174	17	.	.	.
cord-300872-blycbi4u	175	1	The	the	DT
cord-300872-blycbi4u	175	2	hybrid	hybrid	JJ
cord-300872-blycbi4u	175	3	19	19	CD
cord-300872-blycbi4u	175	4	was	be	VBD
cord-300872-blycbi4u	175	5	screened	screen	VBN
cord-300872-blycbi4u	175	6	against	against	IN
cord-300872-blycbi4u	175	7	both	both	DT
cord-300872-blycbi4u	175	8	Gram	gram	NN
cord-300872-blycbi4u	175	9	-	-	HYPH
cord-300872-blycbi4u	175	10	positive	positive	JJ
cord-300872-blycbi4u	175	11	and	and	CC
cord-300872-blycbi4u	175	12	Gram	gram	NN
cord-300872-blycbi4u	175	13	-	-	HYPH
cord-300872-blycbi4u	175	14	negative	negative	JJ
cord-300872-blycbi4u	175	15	(	(	-LRB-
cord-300872-blycbi4u	175	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	175	17	epidermidis	epidermidi	NNS
cord-300872-blycbi4u	175	18	,	,	,
cord-300872-blycbi4u	175	19	S.	S.	NNP
cord-300872-blycbi4u	175	20	aureus	aureus	NN
cord-300872-blycbi4u	175	21	,	,	,
cord-300872-blycbi4u	175	22	Enterococci	Enterococci	NNP
cord-300872-blycbi4u	175	23	faecalis	faecalis	NNP
cord-300872-blycbi4u	175	24	,	,	,
cord-300872-blycbi4u	175	25	and	and	CC
cord-300872-blycbi4u	175	26	E.	E.	NNP
cord-300872-blycbi4u	175	27	faecium	faecium	NN
cord-300872-blycbi4u	175	28	)	)	-RRB-
cord-300872-blycbi4u	176	1	bacterial	bacterial	JJ
cord-300872-blycbi4u	176	2	strains	strain	NNS
cord-300872-blycbi4u	176	3	,	,	,
cord-300872-blycbi4u	176	4	and	and	CC
cord-300872-blycbi4u	176	5	the	the	DT
cord-300872-blycbi4u	176	6	minimum	minimum	JJ
cord-300872-blycbi4u	176	7	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	176	8	concentrations	concentration	NNS
cord-300872-blycbi4u	176	9	(	(	-LRB-
cord-300872-blycbi4u	176	10	MICs	mic	NNS
cord-300872-blycbi4u	176	11	)	)	-RRB-
cord-300872-blycbi4u	176	12	were	be	VBD
cord-300872-blycbi4u	176	13	determined	determine	VBN
cord-300872-blycbi4u	176	14	via	via	IN
cord-300872-blycbi4u	176	15	the	the	DT
cord-300872-blycbi4u	176	16	agar	agar	NNP
cord-300872-blycbi4u	176	17	dilution	dilution	NN
cord-300872-blycbi4u	176	18	method	method	NN
cord-300872-blycbi4u	176	19	.	.	.
cord-300872-blycbi4u	177	1	The	the	DT
cord-300872-blycbi4u	177	2	results	result	NNS
cord-300872-blycbi4u	177	3	indicated	indicate	VBD
cord-300872-blycbi4u	177	4	that	that	IN
cord-300872-blycbi4u	177	5	the	the	DT
cord-300872-blycbi4u	177	6	hybrid	hybrid	NN
cord-300872-blycbi4u	177	7	shows	show	VBZ
cord-300872-blycbi4u	177	8	exciting	exciting	JJ
cord-300872-blycbi4u	177	9	promise	promise	NN
cord-300872-blycbi4u	177	10	against	against	IN
cord-300872-blycbi4u	177	11	both	both	CC
cord-300872-blycbi4u	177	12	Gram	gram	NN
cord-300872-blycbi4u	177	13	-	-	HYPH
cord-300872-blycbi4u	177	14	positive	positive	JJ
cord-300872-blycbi4u	177	15	and	and	CC
cord-300872-blycbi4u	177	16	Gram	gram	NN
cord-300872-blycbi4u	177	17	-	-	HYPH
cord-300872-blycbi4u	177	18	negative	negative	JJ
cord-300872-blycbi4u	177	19	bacteria	bacteria	NNS
cord-300872-blycbi4u	177	20	.	.	.
cord-300872-blycbi4u	178	1	It	-PRON-	PRP
cord-300872-blycbi4u	178	2	displayed	display	VBD
cord-300872-blycbi4u	178	3	significant	significant	JJ
cord-300872-blycbi4u	178	4	effects	effect	NNS
cord-300872-blycbi4u	178	5	against	against	IN
cord-300872-blycbi4u	178	6	both	both	CC
cord-300872-blycbi4u	178	7	susceptible	susceptible	JJ
cord-300872-blycbi4u	178	8	and	and	CC
cord-300872-blycbi4u	178	9	drug	drug	NN
cord-300872-blycbi4u	178	10	-	-	HYPH
cord-300872-blycbi4u	178	11	resistant	resistant	JJ
cord-300872-blycbi4u	178	12	strains	strain	NNS
cord-300872-blycbi4u	178	13	,	,	,
cord-300872-blycbi4u	178	14	with	with	IN
cord-300872-blycbi4u	178	15	MIC	mic	NN
cord-300872-blycbi4u	178	16	values	value	NNS
cord-300872-blycbi4u	178	17	of	of	IN
cord-300872-blycbi4u	178	18	4	4	CD
cord-300872-blycbi4u	178	19	-	-	SYM
cord-300872-blycbi4u	178	20	16	16	CD
cord-300872-blycbi4u	178	21	µg	µg	NN
cord-300872-blycbi4u	178	22	/	/	SYM
cord-300872-blycbi4u	178	23	mL.	ml.	NN
cord-300872-blycbi4u	178	24	These	these	DT
cord-300872-blycbi4u	178	25	values	value	NNS
cord-300872-blycbi4u	178	26	were	be	VBD
cord-300872-blycbi4u	178	27	lower	low	JJR
cord-300872-blycbi4u	178	28	than	than	IN
cord-300872-blycbi4u	178	29	those	those	DT
cord-300872-blycbi4u	178	30	of	of	IN
cord-300872-blycbi4u	178	31	standard	standard	JJ
cord-300872-blycbi4u	178	32	drug	drug	NN
cord-300872-blycbi4u	178	33	(	(	-LRB-
cord-300872-blycbi4u	178	34	ciprofloxacin	ciprofloxacin	NNP
cord-300872-blycbi4u	178	35	)	)	-RRB-
cord-300872-blycbi4u	178	36	,	,	,
cord-300872-blycbi4u	178	37	which	which	WDT
cord-300872-blycbi4u	178	38	has	have	VBZ
cord-300872-blycbi4u	178	39	MIC	mic	NN
cord-300872-blycbi4u	178	40	values	value	NNS
cord-300872-blycbi4u	178	41	of	of	IN
cord-300872-blycbi4u	178	42	0.125	0.125	CD
cord-300872-blycbi4u	178	43	-	-	SYM
cord-300872-blycbi4u	178	44	0.5	0.5	CD
cord-300872-blycbi4u	178	45	µg	µg	NN
cord-300872-blycbi4u	178	46	/	/	SYM
cord-300872-blycbi4u	178	47	mL.	mL.	NNS
cord-300872-blycbi4u	179	1	However	however	RB
cord-300872-blycbi4u	179	2	,	,	,
cord-300872-blycbi4u	179	3	the	the	DT
cord-300872-blycbi4u	179	4	authors	author	NNS
cord-300872-blycbi4u	179	5	speculated	speculate	VBD
cord-300872-blycbi4u	179	6	that	that	IN
cord-300872-blycbi4u	179	7	the	the	DT
cord-300872-blycbi4u	179	8	introduction	introduction	NN
cord-300872-blycbi4u	179	9	of	of	IN
cord-300872-blycbi4u	179	10	a	a	DT
cord-300872-blycbi4u	179	11	quinolone	quinolone	NNP
cord-300872-blycbi4u	179	12	skeleton	skeleton	NN
cord-300872-blycbi4u	179	13	might	may	MD
cord-300872-blycbi4u	179	14	be	be	VB
cord-300872-blycbi4u	179	15	an	an	DT
cord-300872-blycbi4u	179	16	effective	effective	JJ
cord-300872-blycbi4u	179	17	way	way	NN
cord-300872-blycbi4u	179	18	to	to	TO
cord-300872-blycbi4u	179	19	modify	modify	VB
cord-300872-blycbi4u	179	20	these	these	DT
cord-300872-blycbi4u	179	21	kinds	kind	NNS
cord-300872-blycbi4u	179	22	of	of	IN
cord-300872-blycbi4u	179	23	compounds	compound	NNS
cord-300872-blycbi4u	179	24	into	into	IN
cord-300872-blycbi4u	179	25	a	a	DT
cord-300872-blycbi4u	179	26	novel	novel	JJ
cord-300872-blycbi4u	179	27	class	class	NN
cord-300872-blycbi4u	179	28	of	of	IN
cord-300872-blycbi4u	179	29	broad	broad	JJ
cord-300872-blycbi4u	179	30	-	-	HYPH
cord-300872-blycbi4u	179	31	spectrum	spectrum	NN
cord-300872-blycbi4u	179	32	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	179	33	agents	agent	NNS
cord-300872-blycbi4u	179	34	with	with	IN
cord-300872-blycbi4u	179	35	a	a	DT
cord-300872-blycbi4u	179	36	specific	specific	JJ
cord-300872-blycbi4u	179	37	mode	mode	NN
cord-300872-blycbi4u	179	38	of	of	IN
cord-300872-blycbi4u	179	39	action	action	NN
cord-300872-blycbi4u	179	40	.	.	.
cord-300872-blycbi4u	180	1	On	on	IN
cord-300872-blycbi4u	180	2	the	the	DT
cord-300872-blycbi4u	180	3	other	other	JJ
cord-300872-blycbi4u	180	4	hand	hand	NN
cord-300872-blycbi4u	180	5	,	,	,
cord-300872-blycbi4u	180	6	Vu	Vu	NNP
cord-300872-blycbi4u	180	7	and	and	CC
cord-300872-blycbi4u	180	8	coworkers	coworker	NNS
cord-300872-blycbi4u	180	9	prepared	prepare	VBD
cord-300872-blycbi4u	180	10	a	a	DT
cord-300872-blycbi4u	180	11	hybrid	hybrid	JJ
cord-300872-blycbi4u	180	12	compound	compound	NN
cord-300872-blycbi4u	180	13	21	21	CD
cord-300872-blycbi4u	180	14	at	at	IN
cord-300872-blycbi4u	180	15	96	96	CD
cord-300872-blycbi4u	180	16	%	%	NN
cord-300872-blycbi4u	180	17	yield	yield	NN
cord-300872-blycbi4u	180	18	through	through	IN
cord-300872-blycbi4u	180	19	coupling	coupling	NN
cord-300872-blycbi4u	180	20	of	of	IN
cord-300872-blycbi4u	180	21	8-hydroxyquinoline-2-carboxylic	8-hydroxyquinoline-2-carboxylic	CD
cord-300872-blycbi4u	180	22	acid	acid	NN
cord-300872-blycbi4u	180	23	20	20	CD
cord-300872-blycbi4u	180	24	and	and	CC
cord-300872-blycbi4u	180	25	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	180	26	by	by	IN
cord-300872-blycbi4u	180	27	using	use	VBG
cord-300872-blycbi4u	180	28	2-(1H	2-(1h	CD
cord-300872-blycbi4u	180	29	-	-	HYPH
cord-300872-blycbi4u	180	30	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	NN
cord-300872-blycbi4u	180	31	tetrafluoroborate	tetrafluoroborate	NN
cord-300872-blycbi4u	180	32	(	(	-LRB-
cord-300872-blycbi4u	180	33	TBTU	TBTU	NNP
cord-300872-blycbi4u	180	34	)	)	-RRB-
cord-300872-blycbi4u	181	1	and	and	CC
cord-300872-blycbi4u	181	2	N	N	NNP
cord-300872-blycbi4u	181	3	,	,	,
cord-300872-blycbi4u	181	4	N	N	NNP
cord-300872-blycbi4u	181	5	-	-	HYPH
cord-300872-blycbi4u	181	6	diisopropylethylamine	diisopropylethylamine	NNP
cord-300872-blycbi4u	181	7	(	(	-LRB-
cord-300872-blycbi4u	181	8	DIEA	diea	NN
cord-300872-blycbi4u	181	9	)	)	-RRB-
cord-300872-blycbi4u	181	10	(	(	-LRB-
cord-300872-blycbi4u	181	11	Scheme	scheme	NN
cord-300872-blycbi4u	181	12	7	7	CD
cord-300872-blycbi4u	181	13	)	)	-RRB-
cord-300872-blycbi4u	181	14	[	[	-LRB-
cord-300872-blycbi4u	181	15	13	13	CD
cord-300872-blycbi4u	181	16	]	]	-RRB-
cord-300872-blycbi4u	181	17	.	.	.
cord-300872-blycbi4u	182	1	Interestingly	interestingly	RB
cord-300872-blycbi4u	182	2	,	,	,
cord-300872-blycbi4u	182	3	two	two	CD
cord-300872-blycbi4u	182	4	research	research	NN
cord-300872-blycbi4u	182	5	groups	group	NNS
cord-300872-blycbi4u	182	6	have	have	VBP
cord-300872-blycbi4u	182	7	reported	report	VBN
cord-300872-blycbi4u	182	8	on	on	IN
cord-300872-blycbi4u	182	9	the	the	DT
cord-300872-blycbi4u	182	10	hybridization	hybridization	NN
cord-300872-blycbi4u	182	11	of	of	IN
cord-300872-blycbi4u	182	12	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	182	13	with	with	IN
cord-300872-blycbi4u	182	14	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	182	15	in	in	IN
cord-300872-blycbi4u	182	16	a	a	DT
cord-300872-blycbi4u	182	17	single	single	JJ
cord-300872-blycbi4u	182	18	step	step	NN
cord-300872-blycbi4u	182	19	and	and	CC
cord-300872-blycbi4u	182	20	evaluated	evaluate	VBD
cord-300872-blycbi4u	182	21	the	the	DT
cord-300872-blycbi4u	182	22	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	182	23	activity	activity	NN
cord-300872-blycbi4u	182	24	of	of	IN
cord-300872-blycbi4u	182	25	the	the	DT
cord-300872-blycbi4u	182	26	hybrid	hybrid	JJ
cord-300872-blycbi4u	182	27	molecule	molecule	NN
cord-300872-blycbi4u	182	28	.	.	.
cord-300872-blycbi4u	183	1	Fu	Fu	NNP
cord-300872-blycbi4u	183	2	et	et	FW
cord-300872-blycbi4u	183	3	al	al	NNP
cord-300872-blycbi4u	183	4	.	.	NNP
cord-300872-blycbi4u	183	5	reported	report	VBD
cord-300872-blycbi4u	183	6	the	the	DT
cord-300872-blycbi4u	183	7	synthesis	synthesis	NN
cord-300872-blycbi4u	183	8	of	of	IN
cord-300872-blycbi4u	183	9	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	183	10	-	-	HYPH
cord-300872-blycbi4u	183	11	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	183	12	19	19	CD
cord-300872-blycbi4u	183	13	via	via	IN
cord-300872-blycbi4u	183	14	the	the	DT
cord-300872-blycbi4u	183	15	Mannich	Mannich	NNP
cord-300872-blycbi4u	183	16	reaction	reaction	NN
cord-300872-blycbi4u	183	17	(	(	-LRB-
cord-300872-blycbi4u	183	18	Scheme	scheme	NN
cord-300872-blycbi4u	183	19	6	6	CD
cord-300872-blycbi4u	183	20	)	)	-RRB-
cord-300872-blycbi4u	183	21	.	.	.
cord-300872-blycbi4u	184	1	Thus	thus	RB
cord-300872-blycbi4u	184	2	,	,	,
cord-300872-blycbi4u	184	3	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	184	4	18	18	CD
cord-300872-blycbi4u	184	5	reacted	react	VBD
cord-300872-blycbi4u	184	6	with	with	IN
cord-300872-blycbi4u	184	7	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	184	8	in	in	IN
cord-300872-blycbi4u	184	9	the	the	DT
cord-300872-blycbi4u	184	10	presence	presence	NN
cord-300872-blycbi4u	184	11	of	of	IN
cord-300872-blycbi4u	184	12	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	184	13	in	in	IN
cord-300872-blycbi4u	184	14	ethanol	ethanol	NN
cord-300872-blycbi4u	184	15	to	to	TO
cord-300872-blycbi4u	184	16	afford	afford	VB
cord-300872-blycbi4u	184	17	the	the	DT
cord-300872-blycbi4u	184	18	hybrid	hybrid	JJ
cord-300872-blycbi4u	184	19	product	product	NN
cord-300872-blycbi4u	184	20	at	at	IN
cord-300872-blycbi4u	184	21	75	75	CD
cord-300872-blycbi4u	184	22	%	%	NN
cord-300872-blycbi4u	184	23	yield	yield	NN
cord-300872-blycbi4u	184	24	[	[	-LRB-
cord-300872-blycbi4u	184	25	12	12	CD
cord-300872-blycbi4u	184	26	]	]	-RRB-
cord-300872-blycbi4u	184	27	.	.	.
cord-300872-blycbi4u	185	1	The	the	DT
cord-300872-blycbi4u	185	2	hybrid	hybrid	JJ
cord-300872-blycbi4u	185	3	19	19	CD
cord-300872-blycbi4u	185	4	was	be	VBD
cord-300872-blycbi4u	185	5	screened	screen	VBN
cord-300872-blycbi4u	185	6	against	against	IN
cord-300872-blycbi4u	185	7	both	both	DT
cord-300872-blycbi4u	185	8	Gram	gram	NN
cord-300872-blycbi4u	185	9	-	-	HYPH
cord-300872-blycbi4u	185	10	positive	positive	JJ
cord-300872-blycbi4u	185	11	and	and	CC
cord-300872-blycbi4u	185	12	Gram	gram	NN
cord-300872-blycbi4u	185	13	-	-	HYPH
cord-300872-blycbi4u	185	14	negative	negative	JJ
cord-300872-blycbi4u	185	15	(	(	-LRB-
cord-300872-blycbi4u	185	16	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	185	17	epidermidis	epidermidi	NNS
cord-300872-blycbi4u	185	18	,	,	,
cord-300872-blycbi4u	185	19	S.	S.	NNP
cord-300872-blycbi4u	185	20	aureus	aureus	NN
cord-300872-blycbi4u	185	21	,	,	,
cord-300872-blycbi4u	185	22	Enterococci	Enterococci	NNP
cord-300872-blycbi4u	185	23	faecalis	faecalis	NNP
cord-300872-blycbi4u	185	24	,	,	,
cord-300872-blycbi4u	185	25	and	and	CC
cord-300872-blycbi4u	185	26	E.	E.	NNP
cord-300872-blycbi4u	185	27	faecium	faecium	NN
cord-300872-blycbi4u	185	28	)	)	-RRB-
cord-300872-blycbi4u	186	1	bacterial	bacterial	JJ
cord-300872-blycbi4u	186	2	strains	strain	NNS
cord-300872-blycbi4u	186	3	,	,	,
cord-300872-blycbi4u	186	4	and	and	CC
cord-300872-blycbi4u	186	5	the	the	DT
cord-300872-blycbi4u	186	6	minimum	minimum	JJ
cord-300872-blycbi4u	186	7	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	186	8	concentrations	concentration	NNS
cord-300872-blycbi4u	186	9	(	(	-LRB-
cord-300872-blycbi4u	186	10	MICs	mic	NNS
cord-300872-blycbi4u	186	11	)	)	-RRB-
cord-300872-blycbi4u	186	12	were	be	VBD
cord-300872-blycbi4u	186	13	determined	determine	VBN
cord-300872-blycbi4u	186	14	via	via	IN
cord-300872-blycbi4u	186	15	the	the	DT
cord-300872-blycbi4u	186	16	agar	agar	NNP
cord-300872-blycbi4u	186	17	dilution	dilution	NN
cord-300872-blycbi4u	186	18	method	method	NN
cord-300872-blycbi4u	186	19	.	.	.
cord-300872-blycbi4u	187	1	The	the	DT
cord-300872-blycbi4u	187	2	results	result	NNS
cord-300872-blycbi4u	187	3	indicated	indicate	VBD
cord-300872-blycbi4u	187	4	that	that	IN
cord-300872-blycbi4u	187	5	the	the	DT
cord-300872-blycbi4u	187	6	hybrid	hybrid	NN
cord-300872-blycbi4u	187	7	shows	show	VBZ
cord-300872-blycbi4u	187	8	exciting	exciting	JJ
cord-300872-blycbi4u	187	9	promise	promise	NN
cord-300872-blycbi4u	187	10	against	against	IN
cord-300872-blycbi4u	187	11	both	both	CC
cord-300872-blycbi4u	187	12	Gram	gram	NN
cord-300872-blycbi4u	187	13	-	-	HYPH
cord-300872-blycbi4u	187	14	positive	positive	JJ
cord-300872-blycbi4u	187	15	and	and	CC
cord-300872-blycbi4u	187	16	Gram	gram	NN
cord-300872-blycbi4u	187	17	-	-	HYPH
cord-300872-blycbi4u	187	18	negative	negative	JJ
cord-300872-blycbi4u	187	19	bacteria	bacteria	NNS
cord-300872-blycbi4u	187	20	.	.	.
cord-300872-blycbi4u	188	1	It	-PRON-	PRP
cord-300872-blycbi4u	188	2	displayed	display	VBD
cord-300872-blycbi4u	188	3	significant	significant	JJ
cord-300872-blycbi4u	188	4	effects	effect	NNS
cord-300872-blycbi4u	188	5	against	against	IN
cord-300872-blycbi4u	188	6	both	both	CC
cord-300872-blycbi4u	188	7	susceptible	susceptible	JJ
cord-300872-blycbi4u	188	8	and	and	CC
cord-300872-blycbi4u	188	9	drug	drug	NN
cord-300872-blycbi4u	188	10	-	-	HYPH
cord-300872-blycbi4u	188	11	resistant	resistant	JJ
cord-300872-blycbi4u	188	12	strains	strain	NNS
cord-300872-blycbi4u	188	13	,	,	,
cord-300872-blycbi4u	188	14	with	with	IN
cord-300872-blycbi4u	188	15	MIC	mic	NN
cord-300872-blycbi4u	188	16	values	value	NNS
cord-300872-blycbi4u	188	17	of	of	IN
cord-300872-blycbi4u	188	18	4	4	CD
cord-300872-blycbi4u	188	19	-	-	SYM
cord-300872-blycbi4u	188	20	16	16	CD
cord-300872-blycbi4u	188	21	µg	µg	NN
cord-300872-blycbi4u	188	22	/	/	SYM
cord-300872-blycbi4u	188	23	mL.	ml.	NN
cord-300872-blycbi4u	188	24	These	these	DT
cord-300872-blycbi4u	188	25	values	value	NNS
cord-300872-blycbi4u	188	26	were	be	VBD
cord-300872-blycbi4u	188	27	lower	low	JJR
cord-300872-blycbi4u	188	28	than	than	IN
cord-300872-blycbi4u	188	29	those	those	DT
cord-300872-blycbi4u	188	30	of	of	IN
cord-300872-blycbi4u	188	31	standard	standard	JJ
cord-300872-blycbi4u	188	32	drug	drug	NN
cord-300872-blycbi4u	188	33	(	(	-LRB-
cord-300872-blycbi4u	188	34	ciprofloxacin	ciprofloxacin	NNP
cord-300872-blycbi4u	188	35	)	)	-RRB-
cord-300872-blycbi4u	188	36	,	,	,
cord-300872-blycbi4u	188	37	which	which	WDT
cord-300872-blycbi4u	188	38	has	have	VBZ
cord-300872-blycbi4u	188	39	MIC	mic	NN
cord-300872-blycbi4u	188	40	values	value	NNS
cord-300872-blycbi4u	188	41	of	of	IN
cord-300872-blycbi4u	188	42	0.125	0.125	CD
cord-300872-blycbi4u	188	43	-	-	SYM
cord-300872-blycbi4u	188	44	0.5	0.5	CD
cord-300872-blycbi4u	188	45	µg	µg	NN
cord-300872-blycbi4u	188	46	/	/	SYM
cord-300872-blycbi4u	188	47	mL.	mL.	NNS
cord-300872-blycbi4u	189	1	However	however	RB
cord-300872-blycbi4u	189	2	,	,	,
cord-300872-blycbi4u	189	3	the	the	DT
cord-300872-blycbi4u	189	4	authors	author	NNS
cord-300872-blycbi4u	189	5	speculated	speculate	VBD
cord-300872-blycbi4u	189	6	that	that	IN
cord-300872-blycbi4u	189	7	the	the	DT
cord-300872-blycbi4u	189	8	introduction	introduction	NN
cord-300872-blycbi4u	189	9	of	of	IN
cord-300872-blycbi4u	189	10	a	a	DT
cord-300872-blycbi4u	189	11	quinolone	quinolone	NNP
cord-300872-blycbi4u	189	12	skeleton	skeleton	NN
cord-300872-blycbi4u	189	13	might	may	MD
cord-300872-blycbi4u	189	14	be	be	VB
cord-300872-blycbi4u	189	15	an	an	DT
cord-300872-blycbi4u	189	16	effective	effective	JJ
cord-300872-blycbi4u	189	17	way	way	NN
cord-300872-blycbi4u	189	18	to	to	TO
cord-300872-blycbi4u	189	19	modify	modify	VB
cord-300872-blycbi4u	189	20	these	these	DT
cord-300872-blycbi4u	189	21	kinds	kind	NNS
cord-300872-blycbi4u	189	22	of	of	IN
cord-300872-blycbi4u	189	23	compounds	compound	NNS
cord-300872-blycbi4u	189	24	into	into	IN
cord-300872-blycbi4u	189	25	a	a	DT
cord-300872-blycbi4u	189	26	novel	novel	JJ
cord-300872-blycbi4u	189	27	class	class	NN
cord-300872-blycbi4u	189	28	of	of	IN
cord-300872-blycbi4u	189	29	broad	broad	JJ
cord-300872-blycbi4u	189	30	-	-	HYPH
cord-300872-blycbi4u	189	31	spectrum	spectrum	NN
cord-300872-blycbi4u	189	32	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	189	33	agents	agent	NNS
cord-300872-blycbi4u	189	34	with	with	IN
cord-300872-blycbi4u	189	35	a	a	DT
cord-300872-blycbi4u	189	36	specific	specific	JJ
cord-300872-blycbi4u	189	37	mode	mode	NN
cord-300872-blycbi4u	189	38	of	of	IN
cord-300872-blycbi4u	189	39	action	action	NN
cord-300872-blycbi4u	189	40	.	.	.
cord-300872-blycbi4u	190	1	On	on	IN
cord-300872-blycbi4u	190	2	the	the	DT
cord-300872-blycbi4u	190	3	other	other	JJ
cord-300872-blycbi4u	190	4	hand	hand	NN
cord-300872-blycbi4u	190	5	,	,	,
cord-300872-blycbi4u	190	6	Vu	Vu	NNP
cord-300872-blycbi4u	190	7	and	and	CC
cord-300872-blycbi4u	190	8	coworkers	coworker	NNS
cord-300872-blycbi4u	190	9	prepared	prepare	VBD
cord-300872-blycbi4u	190	10	a	a	DT
cord-300872-blycbi4u	190	11	hybrid	hybrid	JJ
cord-300872-blycbi4u	190	12	compound	compound	NN
cord-300872-blycbi4u	190	13	21	21	CD
cord-300872-blycbi4u	190	14	at	at	IN
cord-300872-blycbi4u	190	15	96	96	CD
cord-300872-blycbi4u	190	16	%	%	NN
cord-300872-blycbi4u	190	17	yield	yield	NN
cord-300872-blycbi4u	190	18	through	through	IN
cord-300872-blycbi4u	190	19	coupling	coupling	NN
cord-300872-blycbi4u	190	20	of	of	IN
cord-300872-blycbi4u	190	21	8-hydroxyquinoline-2-carboxylic	8-hydroxyquinoline-2-carboxylic	CD
cord-300872-blycbi4u	190	22	acid	acid	NN
cord-300872-blycbi4u	190	23	20	20	CD
cord-300872-blycbi4u	190	24	and	and	CC
cord-300872-blycbi4u	190	25	ciprofloxacin	ciprofloxacin	NN
cord-300872-blycbi4u	190	26	by	by	IN
cord-300872-blycbi4u	190	27	using	use	VBG
cord-300872-blycbi4u	190	28	2-(1H	2-(1h	CD
cord-300872-blycbi4u	190	29	-	-	HYPH
cord-300872-blycbi4u	190	30	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	benzotriazole-1-yl)-1,1,3,3-tetramethylaminium	NN
cord-300872-blycbi4u	190	31	tetrafluoroborate	tetrafluoroborate	NN
cord-300872-blycbi4u	190	32	(	(	-LRB-
cord-300872-blycbi4u	190	33	TBTU	TBTU	NNP
cord-300872-blycbi4u	190	34	)	)	-RRB-
cord-300872-blycbi4u	191	1	and	and	CC
cord-300872-blycbi4u	191	2	N	N	NNP
cord-300872-blycbi4u	191	3	,	,	,
cord-300872-blycbi4u	191	4	N	N	NNP
cord-300872-blycbi4u	191	5	-	-	HYPH
cord-300872-blycbi4u	191	6	diisopropylethylamine	diisopropylethylamine	NNP
cord-300872-blycbi4u	191	7	(	(	-LRB-
cord-300872-blycbi4u	191	8	DIEA	diea	NN
cord-300872-blycbi4u	191	9	)	)	-RRB-
cord-300872-blycbi4u	191	10	(	(	-LRB-
cord-300872-blycbi4u	191	11	Scheme	scheme	NN
cord-300872-blycbi4u	191	12	7	7	CD
cord-300872-blycbi4u	191	13	)	)	-RRB-
cord-300872-blycbi4u	191	14	[	[	-LRB-
cord-300872-blycbi4u	191	15	13	13	CD
cord-300872-blycbi4u	191	16	]	]	-RRB-
cord-300872-blycbi4u	191	17	.	.	.
cord-300872-blycbi4u	192	1	The	the	DT
cord-300872-blycbi4u	192	2	hybrid	hybrid	NN
cord-300872-blycbi4u	192	3	was	be	VBD
cord-300872-blycbi4u	192	4	screened	screen	VBN
cord-300872-blycbi4u	192	5	for	for	IN
cord-300872-blycbi4u	192	6	cell	cell	NN
cord-300872-blycbi4u	192	7	toxicity	toxicity	NN
cord-300872-blycbi4u	192	8	against	against	IN
cord-300872-blycbi4u	192	9	HeLa	HeLa	NNP
cord-300872-blycbi4u	192	10	cells	cell	NNS
cord-300872-blycbi4u	192	11	,	,	,
cord-300872-blycbi4u	192	12	a	a	DT
cord-300872-blycbi4u	192	13	tumor	tumor	NN
cord-300872-blycbi4u	192	14	cell	cell	NN
cord-300872-blycbi4u	192	15	line	line	NN
cord-300872-blycbi4u	192	16	,	,	,
cord-300872-blycbi4u	192	17	primary	primary	JJ
cord-300872-blycbi4u	192	18	cell	cell	NN
cord-300872-blycbi4u	192	19	cultures	culture	NNS
cord-300872-blycbi4u	192	20	of	of	IN
cord-300872-blycbi4u	192	21	mouse	mouse	NN
cord-300872-blycbi4u	192	22	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	192	23	,	,	,
cord-300872-blycbi4u	192	24	and	and	CC
cord-300872-blycbi4u	192	25	against	against	IN
cord-300872-blycbi4u	192	26	non	non	JJ
cord-300872-blycbi4u	192	27	-	-	JJ
cord-300872-blycbi4u	192	28	cancerous	cancerous	JJ
cord-300872-blycbi4u	192	29	mammalian	mammalian	JJ
cord-300872-blycbi4u	192	30	cell	cell	NN
cord-300872-blycbi4u	192	31	line	line	NN
cord-300872-blycbi4u	192	32	.	.	.
cord-300872-blycbi4u	193	1	It	-PRON-	PRP
cord-300872-blycbi4u	193	2	showed	show	VBD
cord-300872-blycbi4u	193	3	no	no	DT
cord-300872-blycbi4u	193	4	cell	cell	NN
cord-300872-blycbi4u	193	5	toxicity	toxicity	NN
cord-300872-blycbi4u	193	6	at	at	IN
cord-300872-blycbi4u	193	7	the	the	DT
cord-300872-blycbi4u	193	8	concentrations	concentration	NNS
cord-300872-blycbi4u	193	9	tested	test	VBN
cord-300872-blycbi4u	193	10	(	(	-LRB-
cord-300872-blycbi4u	193	11	0	0	CD
cord-300872-blycbi4u	193	12	-	-	SYM
cord-300872-blycbi4u	193	13	200	200	CD
cord-300872-blycbi4u	193	14	µM	µm	NN
cord-300872-blycbi4u	193	15	)	)	-RRB-
cord-300872-blycbi4u	193	16	.	.	.
cord-300872-blycbi4u	194	1	Then	then	RB
cord-300872-blycbi4u	194	2	,	,	,
cord-300872-blycbi4u	194	3	the	the	DT
cord-300872-blycbi4u	194	4	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	194	5	activity	activity	NN
cord-300872-blycbi4u	194	6	was	be	VBD
cord-300872-blycbi4u	194	7	tested	test	VBN
cord-300872-blycbi4u	194	8	against	against	IN
cord-300872-blycbi4u	194	9	Gram	gram	NN
cord-300872-blycbi4u	194	10	-	-	HYPH
cord-300872-blycbi4u	194	11	negative	negative	JJ
cord-300872-blycbi4u	194	12	and	and	CC
cord-300872-blycbi4u	194	13	Gram	gram	NN
cord-300872-blycbi4u	194	14	-	-	HYPH
cord-300872-blycbi4u	194	15	positive	positive	JJ
cord-300872-blycbi4u	194	16	bacteria	bacteria	NNS
cord-300872-blycbi4u	194	17	,	,	,
cord-300872-blycbi4u	194	18	including	include	VBG
cord-300872-blycbi4u	194	19	pathogenic	pathogenic	JJ
cord-300872-blycbi4u	194	20	bacteria	bacteria	NNS
cord-300872-blycbi4u	194	21	present	present	JJ
cord-300872-blycbi4u	194	22	in	in	IN
cord-300872-blycbi4u	194	23	the	the	DT
cord-300872-blycbi4u	194	24	hospital	hospital	NN
cord-300872-blycbi4u	194	25	environment	environment	NN
cord-300872-blycbi4u	194	26	that	that	WDT
cord-300872-blycbi4u	194	27	are	be	VBP
cord-300872-blycbi4u	194	28	difficult	difficult	JJ
cord-300872-blycbi4u	194	29	to	to	TO
cord-300872-blycbi4u	194	30	treat	treat	VB
cord-300872-blycbi4u	194	31	(	(	-LRB-
cord-300872-blycbi4u	194	32	Enterococcus	Enterococcus	NNP
cord-300872-blycbi4u	194	33	faecium	faecium	NN
cord-300872-blycbi4u	194	34	,	,	,
cord-300872-blycbi4u	194	35	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	194	36	aureus	aureus	NN
cord-300872-blycbi4u	194	37	,	,	,
cord-300872-blycbi4u	194	38	Klebsiella	Klebsiella	NNP
cord-300872-blycbi4u	194	39	pneumoniae	pneumoniae	NN
cord-300872-blycbi4u	194	40	,	,	,
cord-300872-blycbi4u	194	41	Acinetobacter	Acinetobacter	NNP
cord-300872-blycbi4u	194	42	baumannii	baumannii	NN
cord-300872-blycbi4u	194	43	,	,	,
cord-300872-blycbi4u	194	44	Pseudomonas	Pseudomonas	NNP
cord-300872-blycbi4u	194	45	aeruginosa	aeruginosa	NN
cord-300872-blycbi4u	194	46	,	,	,
cord-300872-blycbi4u	194	47	and	and	CC
cord-300872-blycbi4u	194	48	Enterobacter	Enterobacter	NNP
cord-300872-blycbi4u	194	49	species	specie	NNS
cord-300872-blycbi4u	194	50	)	)	-RRB-
cord-300872-blycbi4u	194	51	.	.	.
cord-300872-blycbi4u	195	1	The	the	DT
cord-300872-blycbi4u	195	2	results	result	NNS
cord-300872-blycbi4u	195	3	indicated	indicate	VBD
cord-300872-blycbi4u	195	4	that	that	IN
cord-300872-blycbi4u	195	5	that	that	DT
cord-300872-blycbi4u	195	6	hybrid	hybrid	JJ
cord-300872-blycbi4u	195	7	21	21	CD
cord-300872-blycbi4u	195	8	exhibits	exhibit	NNS
cord-300872-blycbi4u	195	9	more	more	RBR
cord-300872-blycbi4u	195	10	potent	potent	JJ
cord-300872-blycbi4u	195	11	activity	activity	NN
cord-300872-blycbi4u	195	12	than	than	IN
cord-300872-blycbi4u	195	13	the	the	DT
cord-300872-blycbi4u	195	14	standard	standard	JJ
cord-300872-blycbi4u	195	15	drug	drug	NN
cord-300872-blycbi4u	195	16	against	against	IN
cord-300872-blycbi4u	195	17	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	195	18	aureus	aureus	NN
cord-300872-blycbi4u	195	19	,	,	,
cord-300872-blycbi4u	195	20	with	with	IN
cord-300872-blycbi4u	195	21	an	an	DT
cord-300872-blycbi4u	195	22	MIC	MIC	NNP
cord-300872-blycbi4u	195	23	(	(	-LRB-
cord-300872-blycbi4u	195	24	mg	mg	NN
cord-300872-blycbi4u	195	25	/	/	SYM
cord-300872-blycbi4u	195	26	mL	ml	NN
cord-300872-blycbi4u	195	27	)	)	-RRB-
cord-300872-blycbi4u	195	28	value	value	NN
cord-300872-blycbi4u	195	29	of	of	IN
cord-300872-blycbi4u	195	30	0.0625	0.0625	CD
cord-300872-blycbi4u	195	31	(	(	-LRB-
cord-300872-blycbi4u	195	32	MIC	MIC	NNP
cord-300872-blycbi4u	195	33	of	of	IN
cord-300872-blycbi4u	195	34	the	the	DT
cord-300872-blycbi4u	195	35	standard	standard	JJ
cord-300872-blycbi4u	195	36	drug	drug	NN
cord-300872-blycbi4u	195	37	=	=	SYM
cord-300872-blycbi4u	195	38	0.125	0.125	CD
cord-300872-blycbi4u	195	39	)	)	-RRB-
cord-300872-blycbi4u	195	40	.	.	.
cord-300872-blycbi4u	196	1	However	however	RB
cord-300872-blycbi4u	196	2	,	,	,
cord-300872-blycbi4u	196	3	the	the	DT
cord-300872-blycbi4u	196	4	hybrid	hybrid	NN
cord-300872-blycbi4u	196	5	was	be	VBD
cord-300872-blycbi4u	196	6	less	less	RBR
cord-300872-blycbi4u	196	7	active	active	JJ
cord-300872-blycbi4u	196	8	against	against	IN
cord-300872-blycbi4u	196	9	the	the	DT
cord-300872-blycbi4u	196	10	rest	rest	NN
cord-300872-blycbi4u	196	11	of	of	IN
cord-300872-blycbi4u	196	12	the	the	DT
cord-300872-blycbi4u	196	13	pathogens	pathogen	NNS
cord-300872-blycbi4u	196	14	as	as	IN
cord-300872-blycbi4u	196	15	compared	compare	VBN
cord-300872-blycbi4u	196	16	to	to	IN
cord-300872-blycbi4u	196	17	the	the	DT
cord-300872-blycbi4u	196	18	standard	standard	JJ
cord-300872-blycbi4u	196	19	drug	drug	NN
cord-300872-blycbi4u	196	20	.	.	.
cord-300872-blycbi4u	197	1	In	in	IN
cord-300872-blycbi4u	197	2	general	general	JJ
cord-300872-blycbi4u	197	3	,	,	,
cord-300872-blycbi4u	197	4	the	the	DT
cord-300872-blycbi4u	197	5	two	two	CD
cord-300872-blycbi4u	197	6	aforementioned	aforementioned	JJ
cord-300872-blycbi4u	197	7	hybrids	hybrid	NNS
cord-300872-blycbi4u	197	8	were	be	VBD
cord-300872-blycbi4u	197	9	systematically	systematically	RB
cord-300872-blycbi4u	197	10	less	less	RBR
cord-300872-blycbi4u	197	11	active	active	JJ
cord-300872-blycbi4u	197	12	than	than	IN
cord-300872-blycbi4u	197	13	the	the	DT
cord-300872-blycbi4u	197	14	parent	parent	NN
cord-300872-blycbi4u	197	15	antibiotic	antibiotic	NN
cord-300872-blycbi4u	197	16	,	,	,
cord-300872-blycbi4u	197	17	ciprofloxacin	ciprofloxacin	NNP
cord-300872-blycbi4u	197	18	.	.	.
cord-300872-blycbi4u	198	1	From	from	IN
cord-300872-blycbi4u	198	2	these	these	DT
cord-300872-blycbi4u	198	3	published	publish	VBN
cord-300872-blycbi4u	198	4	data	datum	NNS
cord-300872-blycbi4u	198	5	,	,	,
cord-300872-blycbi4u	198	6	it	-PRON-	PRP
cord-300872-blycbi4u	198	7	is	be	VBZ
cord-300872-blycbi4u	198	8	obvious	obvious	JJ
cord-300872-blycbi4u	198	9	that	that	IN
cord-300872-blycbi4u	198	10	8-HQ	8-hq	CD
cord-300872-blycbi4u	198	11	could	could	MD
cord-300872-blycbi4u	198	12	be	be	VB
cord-300872-blycbi4u	198	13	an	an	DT
cord-300872-blycbi4u	198	14	important	important	JJ
cord-300872-blycbi4u	198	15	motif	motif	NN
cord-300872-blycbi4u	198	16	for	for	IN
cord-300872-blycbi4u	198	17	future	future	JJ
cord-300872-blycbi4u	198	18	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	198	19	drugs	drug	NNS
cord-300872-blycbi4u	198	20	,	,	,
cord-300872-blycbi4u	198	21	especially	especially	RB
cord-300872-blycbi4u	198	22	against	against	IN
cord-300872-blycbi4u	198	23	antibiotic	antibiotic	JJ
cord-300872-blycbi4u	198	24	-	-	HYPH
cord-300872-blycbi4u	198	25	resistant	resistant	JJ
cord-300872-blycbi4u	198	26	strains	strain	NNS
cord-300872-blycbi4u	198	27	.	.	.
cord-300872-blycbi4u	199	1	However	however	RB
cord-300872-blycbi4u	199	2	,	,	,
cord-300872-blycbi4u	199	3	more	more	JJR
cord-300872-blycbi4u	199	4	research	research	NN
cord-300872-blycbi4u	199	5	is	be	VBZ
cord-300872-blycbi4u	199	6	required	require	VBN
cord-300872-blycbi4u	199	7	,	,	,
cord-300872-blycbi4u	199	8	including	include	VBG
cord-300872-blycbi4u	199	9	experiments	experiment	NNS
cord-300872-blycbi4u	199	10	with	with	IN
cord-300872-blycbi4u	199	11	animals	animal	NNS
cord-300872-blycbi4u	199	12	using	use	VBG
cord-300872-blycbi4u	199	13	newly	newly	RB
cord-300872-blycbi4u	199	14	synthesized	synthesize	VBN
cord-300872-blycbi4u	199	15	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	199	16	agents	agent	NNS
cord-300872-blycbi4u	199	17	.	.	.
cord-300872-blycbi4u	200	1	Fungal	fungal	JJ
cord-300872-blycbi4u	200	2	resistance	resistance	NN
cord-300872-blycbi4u	200	3	to	to	IN
cord-300872-blycbi4u	200	4	antifungal	antifungal	JJ
cord-300872-blycbi4u	200	5	agents	agent	NNS
cord-300872-blycbi4u	200	6	has	have	VBZ
cord-300872-blycbi4u	200	7	become	become	VBN
cord-300872-blycbi4u	200	8	a	a	DT
cord-300872-blycbi4u	200	9	problem	problem	NN
cord-300872-blycbi4u	200	10	and	and	CC
cord-300872-blycbi4u	200	11	a	a	DT
cord-300872-blycbi4u	200	12	challenge	challenge	NN
cord-300872-blycbi4u	200	13	to	to	IN
cord-300872-blycbi4u	200	14	scientists	scientist	NNS
cord-300872-blycbi4u	200	15	in	in	IN
cord-300872-blycbi4u	200	16	recent	recent	JJ
cord-300872-blycbi4u	200	17	years	year	NNS
cord-300872-blycbi4u	200	18	.	.	.
cord-300872-blycbi4u	201	1	This	this	DT
cord-300872-blycbi4u	201	2	resistance	resistance	NN
cord-300872-blycbi4u	201	3	has	have	VBZ
cord-300872-blycbi4u	201	4	serious	serious	JJ
cord-300872-blycbi4u	201	5	implications	implication	NNS
cord-300872-blycbi4u	201	6	for	for	IN
cord-300872-blycbi4u	201	7	morbidity	morbidity	NN
cord-300872-blycbi4u	201	8	,	,	,
cord-300872-blycbi4u	201	9	mortality	mortality	NN
cord-300872-blycbi4u	201	10	,	,	,
cord-300872-blycbi4u	201	11	and	and	CC
cord-300872-blycbi4u	201	12	health	health	NN
cord-300872-blycbi4u	201	13	care	care	NN
cord-300872-blycbi4u	201	14	costs	cost	NNS
cord-300872-blycbi4u	201	15	worldwide	worldwide	RB
cord-300872-blycbi4u	201	16	.	.	.
cord-300872-blycbi4u	202	1	Hence	hence	RB
cord-300872-blycbi4u	202	2	,	,	,
cord-300872-blycbi4u	202	3	attention	attention	NN
cord-300872-blycbi4u	202	4	has	have	VBZ
cord-300872-blycbi4u	202	5	been	be	VBN
cord-300872-blycbi4u	202	6	given	give	VBN
cord-300872-blycbi4u	202	7	to	to	IN
cord-300872-blycbi4u	202	8	understanding	understand	VBG
cord-300872-blycbi4u	202	9	the	the	DT
cord-300872-blycbi4u	202	10	mechanism	mechanism	NN
cord-300872-blycbi4u	202	11	of	of	IN
cord-300872-blycbi4u	202	12	antifungal	antifungal	JJ
cord-300872-blycbi4u	202	13	resistance	resistance	NN
cord-300872-blycbi4u	202	14	in	in	IN
cord-300872-blycbi4u	202	15	order	order	NN
cord-300872-blycbi4u	202	16	to	to	TO
cord-300872-blycbi4u	202	17	develop	develop	VB
cord-300872-blycbi4u	202	18	new	new	JJ
cord-300872-blycbi4u	202	19	treatments	treatment	NNS
cord-300872-blycbi4u	202	20	and	and	CC
cord-300872-blycbi4u	202	21	strategies	strategy	NNS
cord-300872-blycbi4u	202	22	to	to	TO
cord-300872-blycbi4u	202	23	manage	manage	VB
cord-300872-blycbi4u	202	24	infections	infection	NNS
cord-300872-blycbi4u	202	25	caused	cause	VBN
cord-300872-blycbi4u	202	26	by	by	IN
cord-300872-blycbi4u	202	27	resistant	resistant	JJ
cord-300872-blycbi4u	202	28	organisms	organism	NNS
cord-300872-blycbi4u	202	29	.	.	.
cord-300872-blycbi4u	203	1	Along	along	IN
cord-300872-blycbi4u	203	2	this	this	DT
cord-300872-blycbi4u	203	3	line	line	NN
cord-300872-blycbi4u	203	4	,	,	,
cord-300872-blycbi4u	203	5	Le	Le	NNP
cord-300872-blycbi4u	203	6	Pan	Pan	NNP
cord-300872-blycbi4u	203	7	and	and	CC
cord-300872-blycbi4u	203	8	colleagues	colleague	NNS
cord-300872-blycbi4u	203	9	reported	report	VBD
cord-300872-blycbi4u	203	10	the	the	DT
cord-300872-blycbi4u	203	11	synthesis	synthesis	NN
cord-300872-blycbi4u	203	12	of	of	IN
cord-300872-blycbi4u	203	13	conjugates	conjugate	NNS
cord-300872-blycbi4u	203	14	of	of	IN
cord-300872-blycbi4u	203	15	7-hydroxycoumarin	7-hydroxycoumarin	CD
cord-300872-blycbi4u	203	16	(	(	-LRB-
cord-300872-blycbi4u	203	17	umbelliferone	umbelliferone	NN
cord-300872-blycbi4u	203	18	)	)	-RRB-
cord-300872-blycbi4u	203	19	with	with	IN
cord-300872-blycbi4u	203	20	several	several	JJ
cord-300872-blycbi4u	203	21	heterocylic	heterocylic	NN
cord-300872-blycbi4u	203	22	rings	ring	NNS
cord-300872-blycbi4u	203	23	,	,	,
cord-300872-blycbi4u	203	24	including	include	VBG
cord-300872-blycbi4u	203	25	4-and	4-and	CD
cord-300872-blycbi4u	203	26	8-hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	203	27	[	[	-LRB-
cord-300872-blycbi4u	203	28	14	14	CD
cord-300872-blycbi4u	203	29	]	]	-RRB-
cord-300872-blycbi4u	203	30	.	.	.
cord-300872-blycbi4u	204	1	7-Hydroxycoumarin	7-Hydroxycoumarin	NNP
cord-300872-blycbi4u	204	2	was	be	VBD
cord-300872-blycbi4u	204	3	mono	mono	NN
cord-300872-blycbi4u	204	4	-	-	HYPH
cord-300872-blycbi4u	204	5	alkylated	alkylate	VBN
cord-300872-blycbi4u	204	6	in	in	IN
cord-300872-blycbi4u	204	7	moderate	moderate	JJ
cord-300872-blycbi4u	204	8	yields	yield	NNS
cord-300872-blycbi4u	204	9	via	via	IN
cord-300872-blycbi4u	204	10	an	an	DT
cord-300872-blycbi4u	204	11	excess	excess	NN
cord-300872-blycbi4u	204	12	of	of	IN
cord-300872-blycbi4u	204	13	Br-(CH	br-(ch	CD
cord-300872-blycbi4u	204	14	2	2	CD
cord-300872-blycbi4u	204	15	)	)	-RRB-
cord-300872-blycbi4u	205	1	n	n	NNP
cord-300872-blycbi4u	206	1	-Br	-Br	.
cord-300872-blycbi4u	207	1	(	(	-LRB-
cord-300872-blycbi4u	207	2	n	n	NN
cord-300872-blycbi4u	207	3	=	=	SYM
cord-300872-blycbi4u	207	4	2,4	2,4	CD
cord-300872-blycbi4u	207	5	)	)	-RRB-
cord-300872-blycbi4u	208	1	in	in	IN
cord-300872-blycbi4u	208	2	refluxing	refluxe	VBG
cord-300872-blycbi4u	208	3	acetone	acetone	NN
cord-300872-blycbi4u	208	4	in	in	IN
cord-300872-blycbi4u	208	5	the	the	DT
cord-300872-blycbi4u	208	6	presence	presence	NN
cord-300872-blycbi4u	208	7	of	of	IN
cord-300872-blycbi4u	208	8	K	K	NNP
cord-300872-blycbi4u	208	9	2	2	CD
cord-300872-blycbi4u	208	10	CO	CO	NNP
cord-300872-blycbi4u	208	11	3	3	CD
cord-300872-blycbi4u	208	12	-NaOH	-NaOH	.
cord-300872-blycbi4u	208	13	(	(	-LRB-
cord-300872-blycbi4u	208	14	2:1	2:1	CD
cord-300872-blycbi4u	208	15	)	)	-RRB-
cord-300872-blycbi4u	208	16	.	.	.
cord-300872-blycbi4u	209	1	Bromoalkylated	bromoalkylate	VBN
cord-300872-blycbi4u	209	2	coumarins	coumarin	NNS
cord-300872-blycbi4u	209	3	were	be	VBD
cord-300872-blycbi4u	209	4	then	then	RB
cord-300872-blycbi4u	209	5	reacted	react	VBN
cord-300872-blycbi4u	209	6	with	with	IN
cord-300872-blycbi4u	209	7	4-and	4-and	CD
cord-300872-blycbi4u	209	8	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	209	9	in	in	IN
cord-300872-blycbi4u	209	10	the	the	DT
cord-300872-blycbi4u	209	11	presence	presence	NN
cord-300872-blycbi4u	209	12	of	of	IN
cord-300872-blycbi4u	209	13	1	1	CD
cord-300872-blycbi4u	209	14	equivalent	equivalent	NN
cord-300872-blycbi4u	209	15	of	of	IN
cord-300872-blycbi4u	209	16	KOH	KOH	NNP
cord-300872-blycbi4u	209	17	and	and	CC
cord-300872-blycbi4u	209	18	catalytic	catalytic	JJ
cord-300872-blycbi4u	209	19	amounts	amount	NNS
cord-300872-blycbi4u	209	20	of	of	IN
cord-300872-blycbi4u	209	21	KI	KI	NNP
cord-300872-blycbi4u	209	22	and	and	CC
cord-300872-blycbi4u	209	23	tetra	tetra	NNP
cord-300872-blycbi4u	209	24	-	-	HYPH
cord-300872-blycbi4u	209	25	n	n	JJ
cord-300872-blycbi4u	209	26	-	-	HYPH
cord-300872-blycbi4u	209	27	butylammonium	butylammonium	NN
cord-300872-blycbi4u	209	28	bromide	bromide	NN
cord-300872-blycbi4u	209	29	(	(	-LRB-
cord-300872-blycbi4u	209	30	TBAB	TBAB	NNP
cord-300872-blycbi4u	209	31	)	)	-RRB-
cord-300872-blycbi4u	209	32	as	as	IN
cord-300872-blycbi4u	209	33	a	a	DT
cord-300872-blycbi4u	209	34	phase	phase	NN
cord-300872-blycbi4u	209	35	transfer	transfer	NN
cord-300872-blycbi4u	209	36	catalyst	catalyst	NN
cord-300872-blycbi4u	209	37	in	in	IN
cord-300872-blycbi4u	209	38	refluxing	refluxe	VBG
cord-300872-blycbi4u	209	39	acetonitrile	acetonitrile	NN
cord-300872-blycbi4u	209	40	to	to	TO
cord-300872-blycbi4u	209	41	give	give	VB
cord-300872-blycbi4u	209	42	the	the	DT
cord-300872-blycbi4u	209	43	corresponding	correspond	VBG
cord-300872-blycbi4u	209	44	conjugates	conjugate	NNS
cord-300872-blycbi4u	209	45	at	at	IN
cord-300872-blycbi4u	209	46	55	55	CD
cord-300872-blycbi4u	209	47	-	-	SYM
cord-300872-blycbi4u	209	48	80	80	CD
cord-300872-blycbi4u	209	49	%	%	NN
cord-300872-blycbi4u	209	50	yields	yield	NNS
cord-300872-blycbi4u	209	51	(	(	-LRB-
cord-300872-blycbi4u	209	52	Scheme	scheme	NN
cord-300872-blycbi4u	209	53	8)	8)	NN
cord-300872-blycbi4u	209	54	.	.	.
cord-300872-blycbi4u	210	1	Molecules	molecule	NNS
cord-300872-blycbi4u	210	2	2020	2020	CD
cord-300872-blycbi4u	210	3	,	,	,
cord-300872-blycbi4u	210	4	25	25	CD
cord-300872-blycbi4u	210	5	,	,	,
cord-300872-blycbi4u	210	6	x	x	NN
cord-300872-blycbi4u	210	7	FOR	for	IN
cord-300872-blycbi4u	210	8	PEER	PEER	NNP
cord-300872-blycbi4u	210	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	210	10	7	7	CD
cord-300872-blycbi4u	210	11	of	of	IN
cord-300872-blycbi4u	210	12	26	26	CD
cord-300872-blycbi4u	210	13	indicated	indicate	VBD
cord-300872-blycbi4u	210	14	that	that	IN
cord-300872-blycbi4u	210	15	that	that	DT
cord-300872-blycbi4u	210	16	hybrid	hybrid	JJ
cord-300872-blycbi4u	210	17	21	21	CD
cord-300872-blycbi4u	210	18	exhibits	exhibit	NNS
cord-300872-blycbi4u	210	19	more	more	RBR
cord-300872-blycbi4u	210	20	potent	potent	JJ
cord-300872-blycbi4u	210	21	activity	activity	NN
cord-300872-blycbi4u	210	22	than	than	IN
cord-300872-blycbi4u	210	23	the	the	DT
cord-300872-blycbi4u	210	24	standard	standard	JJ
cord-300872-blycbi4u	210	25	drug	drug	NN
cord-300872-blycbi4u	210	26	against	against	IN
cord-300872-blycbi4u	210	27	Staphylococcus	Staphylococcus	NNP
cord-300872-blycbi4u	210	28	aureus	aureus	NN
cord-300872-blycbi4u	210	29	,	,	,
cord-300872-blycbi4u	210	30	with	with	IN
cord-300872-blycbi4u	210	31	an	an	DT
cord-300872-blycbi4u	210	32	MIC	MIC	NNP
cord-300872-blycbi4u	210	33	(	(	-LRB-
cord-300872-blycbi4u	210	34	mg	mg	NN
cord-300872-blycbi4u	210	35	/	/	SYM
cord-300872-blycbi4u	210	36	mL	ml	NN
cord-300872-blycbi4u	210	37	)	)	-RRB-
cord-300872-blycbi4u	210	38	value	value	NN
cord-300872-blycbi4u	210	39	of	of	IN
cord-300872-blycbi4u	210	40	0.0625	0.0625	CD
cord-300872-blycbi4u	210	41	(	(	-LRB-
cord-300872-blycbi4u	210	42	MIC	MIC	NNP
cord-300872-blycbi4u	210	43	of	of	IN
cord-300872-blycbi4u	210	44	the	the	DT
cord-300872-blycbi4u	210	45	standard	standard	JJ
cord-300872-blycbi4u	210	46	drug	drug	NN
cord-300872-blycbi4u	210	47	=	=	SYM
cord-300872-blycbi4u	210	48	0.125	0.125	CD
cord-300872-blycbi4u	210	49	)	)	-RRB-
cord-300872-blycbi4u	210	50	.	.	.
cord-300872-blycbi4u	211	1	However	however	RB
cord-300872-blycbi4u	211	2	,	,	,
cord-300872-blycbi4u	211	3	the	the	DT
cord-300872-blycbi4u	211	4	hybrid	hybrid	NN
cord-300872-blycbi4u	211	5	was	be	VBD
cord-300872-blycbi4u	211	6	less	less	RBR
cord-300872-blycbi4u	211	7	active	active	JJ
cord-300872-blycbi4u	211	8	against	against	IN
cord-300872-blycbi4u	211	9	the	the	DT
cord-300872-blycbi4u	211	10	rest	rest	NN
cord-300872-blycbi4u	211	11	of	of	IN
cord-300872-blycbi4u	211	12	the	the	DT
cord-300872-blycbi4u	211	13	pathogens	pathogen	NNS
cord-300872-blycbi4u	211	14	as	as	IN
cord-300872-blycbi4u	211	15	compared	compare	VBN
cord-300872-blycbi4u	211	16	to	to	IN
cord-300872-blycbi4u	211	17	the	the	DT
cord-300872-blycbi4u	211	18	standard	standard	JJ
cord-300872-blycbi4u	211	19	drug	drug	NN
cord-300872-blycbi4u	211	20	.	.	.
cord-300872-blycbi4u	212	1	In	in	IN
cord-300872-blycbi4u	212	2	general	general	JJ
cord-300872-blycbi4u	212	3	,	,	,
cord-300872-blycbi4u	212	4	the	the	DT
cord-300872-blycbi4u	212	5	two	two	CD
cord-300872-blycbi4u	212	6	aforementioned	aforementioned	JJ
cord-300872-blycbi4u	212	7	hybrids	hybrid	NNS
cord-300872-blycbi4u	212	8	were	be	VBD
cord-300872-blycbi4u	212	9	systematically	systematically	RB
cord-300872-blycbi4u	212	10	less	less	RBR
cord-300872-blycbi4u	212	11	active	active	JJ
cord-300872-blycbi4u	212	12	than	than	IN
cord-300872-blycbi4u	212	13	the	the	DT
cord-300872-blycbi4u	212	14	parent	parent	NN
cord-300872-blycbi4u	212	15	antibiotic	antibiotic	NN
cord-300872-blycbi4u	212	16	,	,	,
cord-300872-blycbi4u	212	17	ciprofloxacin	ciprofloxacin	NNP
cord-300872-blycbi4u	212	18	.	.	.
cord-300872-blycbi4u	213	1	From	from	IN
cord-300872-blycbi4u	213	2	these	these	DT
cord-300872-blycbi4u	213	3	published	publish	VBN
cord-300872-blycbi4u	213	4	data	datum	NNS
cord-300872-blycbi4u	213	5	,	,	,
cord-300872-blycbi4u	213	6	it	-PRON-	PRP
cord-300872-blycbi4u	213	7	is	be	VBZ
cord-300872-blycbi4u	213	8	obvious	obvious	JJ
cord-300872-blycbi4u	213	9	that	that	IN
cord-300872-blycbi4u	213	10	8-HQ	8-hq	CD
cord-300872-blycbi4u	213	11	could	could	MD
cord-300872-blycbi4u	213	12	be	be	VB
cord-300872-blycbi4u	213	13	an	an	DT
cord-300872-blycbi4u	213	14	important	important	JJ
cord-300872-blycbi4u	213	15	motif	motif	NN
cord-300872-blycbi4u	213	16	for	for	IN
cord-300872-blycbi4u	213	17	future	future	JJ
cord-300872-blycbi4u	213	18	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	213	19	drugs	drug	NNS
cord-300872-blycbi4u	213	20	,	,	,
cord-300872-blycbi4u	213	21	especially	especially	RB
cord-300872-blycbi4u	213	22	against	against	IN
cord-300872-blycbi4u	213	23	antibiotic	antibiotic	JJ
cord-300872-blycbi4u	213	24	-	-	HYPH
cord-300872-blycbi4u	213	25	resistant	resistant	JJ
cord-300872-blycbi4u	213	26	strains	strain	NNS
cord-300872-blycbi4u	213	27	.	.	.
cord-300872-blycbi4u	214	1	However	however	RB
cord-300872-blycbi4u	214	2	,	,	,
cord-300872-blycbi4u	214	3	more	more	JJR
cord-300872-blycbi4u	214	4	research	research	NN
cord-300872-blycbi4u	214	5	is	be	VBZ
cord-300872-blycbi4u	214	6	required	require	VBN
cord-300872-blycbi4u	214	7	,	,	,
cord-300872-blycbi4u	214	8	including	include	VBG
cord-300872-blycbi4u	214	9	experiments	experiment	NNS
cord-300872-blycbi4u	214	10	with	with	IN
cord-300872-blycbi4u	214	11	animals	animal	NNS
cord-300872-blycbi4u	214	12	using	use	VBG
cord-300872-blycbi4u	214	13	newly	newly	RB
cord-300872-blycbi4u	214	14	synthesized	synthesize	VBN
cord-300872-blycbi4u	214	15	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	214	16	agents	agent	NNS
cord-300872-blycbi4u	214	17	.	.	.
cord-300872-blycbi4u	215	1	Fungal	fungal	JJ
cord-300872-blycbi4u	215	2	resistance	resistance	NN
cord-300872-blycbi4u	215	3	to	to	IN
cord-300872-blycbi4u	215	4	antifungal	antifungal	JJ
cord-300872-blycbi4u	215	5	agents	agent	NNS
cord-300872-blycbi4u	215	6	has	have	VBZ
cord-300872-blycbi4u	215	7	become	become	VBN
cord-300872-blycbi4u	215	8	a	a	DT
cord-300872-blycbi4u	215	9	problem	problem	NN
cord-300872-blycbi4u	215	10	and	and	CC
cord-300872-blycbi4u	215	11	a	a	DT
cord-300872-blycbi4u	215	12	challenge	challenge	NN
cord-300872-blycbi4u	215	13	to	to	IN
cord-300872-blycbi4u	215	14	scientists	scientist	NNS
cord-300872-blycbi4u	215	15	in	in	IN
cord-300872-blycbi4u	215	16	recent	recent	JJ
cord-300872-blycbi4u	215	17	years	year	NNS
cord-300872-blycbi4u	215	18	.	.	.
cord-300872-blycbi4u	216	1	This	this	DT
cord-300872-blycbi4u	216	2	resistance	resistance	NN
cord-300872-blycbi4u	216	3	has	have	VBZ
cord-300872-blycbi4u	216	4	serious	serious	JJ
cord-300872-blycbi4u	216	5	implications	implication	NNS
cord-300872-blycbi4u	216	6	for	for	IN
cord-300872-blycbi4u	216	7	morbidity	morbidity	NN
cord-300872-blycbi4u	216	8	,	,	,
cord-300872-blycbi4u	216	9	mortality	mortality	NN
cord-300872-blycbi4u	216	10	,	,	,
cord-300872-blycbi4u	216	11	and	and	CC
cord-300872-blycbi4u	216	12	health	health	NN
cord-300872-blycbi4u	216	13	care	care	NN
cord-300872-blycbi4u	216	14	costs	cost	NNS
cord-300872-blycbi4u	216	15	worldwide	worldwide	RB
cord-300872-blycbi4u	216	16	.	.	.
cord-300872-blycbi4u	217	1	Hence	hence	RB
cord-300872-blycbi4u	217	2	,	,	,
cord-300872-blycbi4u	217	3	attention	attention	NN
cord-300872-blycbi4u	217	4	has	have	VBZ
cord-300872-blycbi4u	217	5	been	be	VBN
cord-300872-blycbi4u	217	6	given	give	VBN
cord-300872-blycbi4u	217	7	to	to	IN
cord-300872-blycbi4u	217	8	understanding	understand	VBG
cord-300872-blycbi4u	217	9	the	the	DT
cord-300872-blycbi4u	217	10	mechanism	mechanism	NN
cord-300872-blycbi4u	217	11	of	of	IN
cord-300872-blycbi4u	217	12	antifungal	antifungal	JJ
cord-300872-blycbi4u	217	13	resistance	resistance	NN
cord-300872-blycbi4u	217	14	in	in	IN
cord-300872-blycbi4u	217	15	order	order	NN
cord-300872-blycbi4u	217	16	to	to	TO
cord-300872-blycbi4u	217	17	develop	develop	VB
cord-300872-blycbi4u	217	18	new	new	JJ
cord-300872-blycbi4u	217	19	treatments	treatment	NNS
cord-300872-blycbi4u	217	20	and	and	CC
cord-300872-blycbi4u	217	21	strategies	strategy	NNS
cord-300872-blycbi4u	217	22	to	to	TO
cord-300872-blycbi4u	217	23	manage	manage	VB
cord-300872-blycbi4u	217	24	infections	infection	NNS
cord-300872-blycbi4u	217	25	caused	cause	VBN
cord-300872-blycbi4u	217	26	by	by	IN
cord-300872-blycbi4u	217	27	resistant	resistant	JJ
cord-300872-blycbi4u	217	28	organisms	organism	NNS
cord-300872-blycbi4u	217	29	.	.	.
cord-300872-blycbi4u	218	1	Along	along	IN
cord-300872-blycbi4u	218	2	this	this	DT
cord-300872-blycbi4u	218	3	line	line	NN
cord-300872-blycbi4u	218	4	,	,	,
cord-300872-blycbi4u	218	5	Le	Le	NNP
cord-300872-blycbi4u	218	6	Pan	Pan	NNP
cord-300872-blycbi4u	218	7	and	and	CC
cord-300872-blycbi4u	218	8	colleagues	colleague	NNS
cord-300872-blycbi4u	218	9	reported	report	VBD
cord-300872-blycbi4u	218	10	the	the	DT
cord-300872-blycbi4u	218	11	synthesis	synthesis	NN
cord-300872-blycbi4u	218	12	of	of	IN
cord-300872-blycbi4u	218	13	conjugates	conjugate	NNS
cord-300872-blycbi4u	218	14	of	of	IN
cord-300872-blycbi4u	218	15	7hydroxycoumarin	7hydroxycoumarin	CD
cord-300872-blycbi4u	218	16	(	(	-LRB-
cord-300872-blycbi4u	218	17	umbelliferone	umbelliferone	NN
cord-300872-blycbi4u	218	18	)	)	-RRB-
cord-300872-blycbi4u	218	19	with	with	IN
cord-300872-blycbi4u	218	20	several	several	JJ
cord-300872-blycbi4u	218	21	heterocylic	heterocylic	NN
cord-300872-blycbi4u	218	22	rings	ring	NNS
cord-300872-blycbi4u	218	23	,	,	,
cord-300872-blycbi4u	218	24	including	include	VBG
cord-300872-blycbi4u	218	25	4-and	4-and	CD
cord-300872-blycbi4u	218	26	8hydroxyquinolines	8hydroxyquinolines	CD
cord-300872-blycbi4u	218	27	[	[	-LRB-
cord-300872-blycbi4u	218	28	14	14	CD
cord-300872-blycbi4u	218	29	]	]	-RRB-
cord-300872-blycbi4u	218	30	.	.	.
cord-300872-blycbi4u	219	1	7-Hydroxycoumarin	7-Hydroxycoumarin	NNP
cord-300872-blycbi4u	219	2	was	be	VBD
cord-300872-blycbi4u	219	3	mono	mono	NN
cord-300872-blycbi4u	219	4	-	-	HYPH
cord-300872-blycbi4u	219	5	alkylated	alkylate	VBN
cord-300872-blycbi4u	219	6	in	in	IN
cord-300872-blycbi4u	219	7	moderate	moderate	JJ
cord-300872-blycbi4u	219	8	yields	yield	NNS
cord-300872-blycbi4u	219	9	via	via	IN
cord-300872-blycbi4u	219	10	an	an	DT
cord-300872-blycbi4u	219	11	excess	excess	NN
cord-300872-blycbi4u	219	12	of	of	IN
cord-300872-blycbi4u	219	13	Br-(CH2)n	br-(ch2)n	NN
cord-300872-blycbi4u	219	14	-	-	HYPH
cord-300872-blycbi4u	219	15	Br	Br	NNP
cord-300872-blycbi4u	219	16	(	(	-LRB-
cord-300872-blycbi4u	219	17	n	n	NN
cord-300872-blycbi4u	219	18	=	=	SYM
cord-300872-blycbi4u	219	19	2,4	2,4	CD
cord-300872-blycbi4u	219	20	)	)	-RRB-
cord-300872-blycbi4u	219	21	in	in	IN
cord-300872-blycbi4u	219	22	refluxing	refluxe	VBG
cord-300872-blycbi4u	219	23	acetone	acetone	NN
cord-300872-blycbi4u	219	24	in	in	IN
cord-300872-blycbi4u	219	25	the	the	DT
cord-300872-blycbi4u	219	26	presence	presence	NN
cord-300872-blycbi4u	219	27	of	of	IN
cord-300872-blycbi4u	219	28	K2CO3-NaOH	K2CO3-NaOH	NNP
cord-300872-blycbi4u	219	29	(	(	-LRB-
cord-300872-blycbi4u	219	30	2:1	2:1	CD
cord-300872-blycbi4u	219	31	)	)	-RRB-
cord-300872-blycbi4u	219	32	.	.	.
cord-300872-blycbi4u	220	1	Bromoalkylated	bromoalkylate	VBN
cord-300872-blycbi4u	220	2	coumarins	coumarin	NNS
cord-300872-blycbi4u	220	3	were	be	VBD
cord-300872-blycbi4u	220	4	then	then	RB
cord-300872-blycbi4u	220	5	reacted	react	VBN
cord-300872-blycbi4u	220	6	with	with	IN
cord-300872-blycbi4u	220	7	4-and	4-and	CD
cord-300872-blycbi4u	220	8	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	220	9	in	in	IN
cord-300872-blycbi4u	220	10	the	the	DT
cord-300872-blycbi4u	220	11	presence	presence	NN
cord-300872-blycbi4u	220	12	of	of	IN
cord-300872-blycbi4u	220	13	1	1	CD
cord-300872-blycbi4u	220	14	equivalent	equivalent	NN
cord-300872-blycbi4u	220	15	of	of	IN
cord-300872-blycbi4u	220	16	KOH	KOH	NNP
cord-300872-blycbi4u	220	17	and	and	CC
cord-300872-blycbi4u	220	18	catalytic	catalytic	JJ
cord-300872-blycbi4u	220	19	amounts	amount	NNS
cord-300872-blycbi4u	220	20	of	of	IN
cord-300872-blycbi4u	220	21	KI	KI	NNP
cord-300872-blycbi4u	220	22	and	and	CC
cord-300872-blycbi4u	220	23	tetra	tetra	NNP
cord-300872-blycbi4u	220	24	-	-	HYPH
cord-300872-blycbi4u	220	25	n	n	JJ
cord-300872-blycbi4u	220	26	-	-	HYPH
cord-300872-blycbi4u	220	27	butylammonium	butylammonium	NN
cord-300872-blycbi4u	220	28	bromide	bromide	NN
cord-300872-blycbi4u	220	29	(	(	-LRB-
cord-300872-blycbi4u	220	30	TBAB	TBAB	NNP
cord-300872-blycbi4u	220	31	)	)	-RRB-
cord-300872-blycbi4u	220	32	as	as	IN
cord-300872-blycbi4u	220	33	a	a	DT
cord-300872-blycbi4u	220	34	phase	phase	NN
cord-300872-blycbi4u	220	35	transfer	transfer	NN
cord-300872-blycbi4u	220	36	catalyst	catalyst	NN
cord-300872-blycbi4u	220	37	in	in	IN
cord-300872-blycbi4u	220	38	refluxing	refluxe	VBG
cord-300872-blycbi4u	220	39	acetonitrile	acetonitrile	NN
cord-300872-blycbi4u	220	40	to	to	TO
cord-300872-blycbi4u	220	41	give	give	VB
cord-300872-blycbi4u	220	42	the	the	DT
cord-300872-blycbi4u	220	43	corresponding	correspond	VBG
cord-300872-blycbi4u	220	44	conjugates	conjugate	NNS
cord-300872-blycbi4u	220	45	at	at	IN
cord-300872-blycbi4u	220	46	55	55	CD
cord-300872-blycbi4u	220	47	-	-	SYM
cord-300872-blycbi4u	220	48	80	80	CD
cord-300872-blycbi4u	220	49	%	%	NN
cord-300872-blycbi4u	220	50	yields	yield	NNS
cord-300872-blycbi4u	220	51	(	(	-LRB-
cord-300872-blycbi4u	220	52	Scheme	scheme	NN
cord-300872-blycbi4u	220	53	8)	8)	NN
cord-300872-blycbi4u	220	54	.	.	.
cord-300872-blycbi4u	221	1	The	the	DT
cord-300872-blycbi4u	221	2	antifungal	antifungal	JJ
cord-300872-blycbi4u	221	3	activity	activity	NN
cord-300872-blycbi4u	221	4	of	of	IN
cord-300872-blycbi4u	221	5	these	these	DT
cord-300872-blycbi4u	221	6	new	new	JJ
cord-300872-blycbi4u	221	7	conjugates	conjugate	NNS
cord-300872-blycbi4u	221	8	against	against	IN
cord-300872-blycbi4u	221	9	four	four	CD
cord-300872-blycbi4u	221	10	phytopathogenic	phytopathogenic	JJ
cord-300872-blycbi4u	221	11	fungi	fungus	NNS
cord-300872-blycbi4u	221	12	(	(	-LRB-
cord-300872-blycbi4u	221	13	A.	A.	NNP
cord-300872-blycbi4u	221	14	alternate	alternate	JJ
cord-300872-blycbi4u	221	15	,	,	,
cord-300872-blycbi4u	221	16	A.	a.	NN
cord-300872-blycbi4u	221	17	solani	solani	NNS
cord-300872-blycbi4u	221	18	,	,	,
cord-300872-blycbi4u	221	19	B.	B.	NNP
cord-300872-blycbi4u	221	20	cinerea	cinerea	NN
cord-300872-blycbi4u	221	21	,	,	,
cord-300872-blycbi4u	221	22	and	and	CC
cord-300872-blycbi4u	221	23	F.	F.	NNP
cord-300872-blycbi4u	221	24	oxysporum	oxysporum	NNP
cord-300872-blycbi4u	221	25	)	)	-RRB-
cord-300872-blycbi4u	221	26	was	be	VBD
cord-300872-blycbi4u	221	27	evaluated	evaluate	VBN
cord-300872-blycbi4u	221	28	by	by	IN
cord-300872-blycbi4u	221	29	measuring	measure	VBG
cord-300872-blycbi4u	221	30	the	the	DT
cord-300872-blycbi4u	221	31	mycelial	mycelial	JJ
cord-300872-blycbi4u	221	32	inhibition	inhibition	NN
cord-300872-blycbi4u	221	33	of	of	IN
cord-300872-blycbi4u	221	34	radial	radial	JJ
cord-300872-blycbi4u	221	35	growth	growth	NN
cord-300872-blycbi4u	221	36	on	on	IN
cord-300872-blycbi4u	221	37	potato	potato	NN
cord-300872-blycbi4u	221	38	dextrose	dextrose	NN
cord-300872-blycbi4u	221	39	agar	agar	NN
cord-300872-blycbi4u	221	40	(	(	-LRB-
cord-300872-blycbi4u	221	41	PDA	pda	NN
cord-300872-blycbi4u	221	42	)	)	-RRB-
cord-300872-blycbi4u	221	43	media	medium	NNS
cord-300872-blycbi4u	221	44	compared	compare	VBN
cord-300872-blycbi4u	221	45	to	to	IN
cord-300872-blycbi4u	221	46	the	the	DT
cord-300872-blycbi4u	221	47	commercial	commercial	JJ
cord-300872-blycbi4u	221	48	fungicide	fungicide	NN
cord-300872-blycbi4u	221	49	carbendazim	carbendazim	NN
cord-300872-blycbi4u	221	50	.	.	.
cord-300872-blycbi4u	222	1	The	the	DT
cord-300872-blycbi4u	222	2	inhibition	inhibition	NN
cord-300872-blycbi4u	222	3	percentages	percentage	NNS
cord-300872-blycbi4u	222	4	of	of	IN
cord-300872-blycbi4u	222	5	radial	radial	JJ
cord-300872-blycbi4u	222	6	growth	growth	NN
cord-300872-blycbi4u	222	7	against	against	IN
cord-300872-blycbi4u	222	8	all	all	DT
cord-300872-blycbi4u	222	9	of	of	IN
cord-300872-blycbi4u	222	10	these	these	DT
cord-300872-blycbi4u	222	11	fungi	fungus	NNS
cord-300872-blycbi4u	222	12	for	for	IN
cord-300872-blycbi4u	222	13	umbelliferone-8hydroxyquinoline	umbelliferone-8hydroxyquinoline	JJ
cord-300872-blycbi4u	222	14	(	(	-LRB-
cord-300872-blycbi4u	222	15	n	n	NN
cord-300872-blycbi4u	222	16	=	=	SYM
cord-300872-blycbi4u	222	17	2	2	CD
cord-300872-blycbi4u	222	18	)	)	-RRB-
cord-300872-blycbi4u	222	19	,	,	,
cord-300872-blycbi4u	222	20	umbelliferone-8-hydroxyquinoline	umbelliferone-8-hydroxyquinoline	NNP
cord-300872-blycbi4u	222	21	(	(	-LRB-
cord-300872-blycbi4u	222	22	n	n	NN
cord-300872-blycbi4u	222	23	=	=	SYM
cord-300872-blycbi4u	222	24	4	4	CD
cord-300872-blycbi4u	222	25	)	)	-RRB-
cord-300872-blycbi4u	222	26	,	,	,
cord-300872-blycbi4u	222	27	and	and	CC
cord-300872-blycbi4u	222	28	umbelliferone-4hydroxyquinoline	umbelliferone-4hydroxyquinoline	JJ
cord-300872-blycbi4u	222	29	(	(	-LRB-
cord-300872-blycbi4u	222	30	n	n	NN
cord-300872-blycbi4u	222	31	=	=	SYM
cord-300872-blycbi4u	222	32	4	4	CD
cord-300872-blycbi4u	222	33	)	)	-RRB-
cord-300872-blycbi4u	222	34	were	be	VBD
cord-300872-blycbi4u	222	35	49	49	CD
cord-300872-blycbi4u	222	36	-	-	SYM
cord-300872-blycbi4u	222	37	63	63	CD
cord-300872-blycbi4u	222	38	,	,	,
cord-300872-blycbi4u	222	39	57	57	CD
cord-300872-blycbi4u	222	40	-	-	SYM
cord-300872-blycbi4u	222	41	90	90	CD
cord-300872-blycbi4u	222	42	,	,	,
cord-300872-blycbi4u	222	43	and	and	CC
cord-300872-blycbi4u	222	44	18	18	CD
cord-300872-blycbi4u	222	45	-	-	SYM
cord-300872-blycbi4u	222	46	41	41	CD
cord-300872-blycbi4u	222	47	%	%	NN
cord-300872-blycbi4u	222	48	,	,	,
cord-300872-blycbi4u	222	49	respectively	respectively	RB
cord-300872-blycbi4u	222	50	,	,	,
cord-300872-blycbi4u	222	51	compared	compare	VBN
cord-300872-blycbi4u	222	52	to	to	IN
cord-300872-blycbi4u	222	53	carbendazim	carbendazim	NN
cord-300872-blycbi4u	222	54	(	(	-LRB-
cord-300872-blycbi4u	222	55	95	95	CD
cord-300872-blycbi4u	222	56	-	-	SYM
cord-300872-blycbi4u	222	57	99	99	CD
cord-300872-blycbi4u	222	58	%	%	NN
cord-300872-blycbi4u	222	59	)	)	-RRB-
cord-300872-blycbi4u	222	60	at	at	IN
cord-300872-blycbi4u	222	61	200	200	CD
cord-300872-blycbi4u	222	62	µg	µg	NN
cord-300872-blycbi4u	222	63	/	/	SYM
cord-300872-blycbi4u	222	64	mL	ml	NN
cord-300872-blycbi4u	222	65	concentration	concentration	NN
cord-300872-blycbi4u	222	66	.	.	.
cord-300872-blycbi4u	223	1	When	when	WRB
cord-300872-blycbi4u	223	2	these	these	DT
cord-300872-blycbi4u	223	3	derivatives	derivative	NNS
cord-300872-blycbi4u	223	4	were	be	VBD
cord-300872-blycbi4u	223	5	tested	test	VBN
cord-300872-blycbi4u	223	6	at	at	IN
cord-300872-blycbi4u	223	7	a	a	DT
cord-300872-blycbi4u	223	8	series	series	NN
cord-300872-blycbi4u	223	9	of	of	IN
cord-300872-blycbi4u	223	10	lower	low	JJR
cord-300872-blycbi4u	223	11	concentrations	concentration	NNS
cord-300872-blycbi4u	223	12	to	to	TO
cord-300872-blycbi4u	223	13	measure	measure	VB
cord-300872-blycbi4u	223	14	the	the	DT
cord-300872-blycbi4u	223	15	half	half	RB
cord-300872-blycbi4u	223	16	-	-	HYPH
cord-300872-blycbi4u	223	17	maximal	maximal	JJ
cord-300872-blycbi4u	223	18	effective	effective	JJ
cord-300872-blycbi4u	223	19	concentration	concentration	NN
cord-300872-blycbi4u	223	20	(	(	-LRB-
cord-300872-blycbi4u	223	21	µg	µg	NN
cord-300872-blycbi4u	223	22	/	/	SYM
cord-300872-blycbi4u	223	23	mL	mL	NNP
cord-300872-blycbi4u	223	24	)	)	-RRB-
cord-300872-blycbi4u	223	25	,	,	,
cord-300872-blycbi4u	223	26	umbelliferone-8hydroxyquinoline	umbelliferone-8hydroxyquinoline	JJ
cord-300872-blycbi4u	223	27	(	(	-LRB-
cord-300872-blycbi4u	223	28	n	n	NN
cord-300872-blycbi4u	223	29	=	=	SYM
cord-300872-blycbi4u	223	30	4	4	CD
cord-300872-blycbi4u	223	31	)	)	-RRB-
cord-300872-blycbi4u	223	32	was	be	VBD
cord-300872-blycbi4u	223	33	the	the	DT
cord-300872-blycbi4u	223	34	most	most	RBS
cord-300872-blycbi4u	223	35	active	active	JJ
cord-300872-blycbi4u	223	36	compared	compare	VBN
cord-300872-blycbi4u	223	37	to	to	IN
cord-300872-blycbi4u	223	38	the	the	DT
cord-300872-blycbi4u	223	39	reference	reference	NN
cord-300872-blycbi4u	223	40	drug	drug	NN
cord-300872-blycbi4u	223	41	at	at	IN
cord-300872-blycbi4u	223	42	10.6	10.6	CD
cord-300872-blycbi4u	223	43	and	and	CC
cord-300872-blycbi4u	223	44	2.3	2.3	CD
cord-300872-blycbi4u	223	45	µg	µg	NN
cord-300872-blycbi4u	223	46	/	/	SYM
cord-300872-blycbi4u	223	47	mL	ml	NN
cord-300872-blycbi4u	223	48	,	,	,
cord-300872-blycbi4u	223	49	respectively	respectively	RB
cord-300872-blycbi4u	223	50	.	.	.
cord-300872-blycbi4u	224	1	The	the	DT
cord-300872-blycbi4u	224	2	rest	rest	NN
cord-300872-blycbi4u	224	3	of	of	IN
cord-300872-blycbi4u	224	4	the	the	DT
cord-300872-blycbi4u	224	5	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	224	6	derivatives	derivative	NNS
cord-300872-blycbi4u	224	7	exhibited	exhibit	VBD
cord-300872-blycbi4u	224	8	weak	weak	JJ
cord-300872-blycbi4u	224	9	activity	activity	NN
cord-300872-blycbi4u	224	10	.	.	.
cord-300872-blycbi4u	225	1	The	the	DT
cord-300872-blycbi4u	225	2	results	result	NNS
cord-300872-blycbi4u	225	3	also	also	RB
cord-300872-blycbi4u	225	4	showed	show	VBD
cord-300872-blycbi4u	225	5	that	that	IN
cord-300872-blycbi4u	225	6	umbelliferone	umbelliferone	JJ
cord-300872-blycbi4u	225	7	derivatives	derivative	NNS
cord-300872-blycbi4u	225	8	with	with	IN
cord-300872-blycbi4u	225	9	a	a	DT
cord-300872-blycbi4u	225	10	spacer	spacer	NN
cord-300872-blycbi4u	225	11	of	of	IN
cord-300872-blycbi4u	225	12	4	4	CD
cord-300872-blycbi4u	225	13	carbon	carbon	NN
cord-300872-blycbi4u	225	14	atoms	atom	NNS
cord-300872-blycbi4u	225	15	exhibit	exhibit	VBP
cord-300872-blycbi4u	226	1	better	well	JJR
cord-300872-blycbi4u	226	2	antifungal	antifungal	NNP
cord-300872-blycbi4u	227	1	The	the	DT
cord-300872-blycbi4u	227	2	antifungal	antifungal	JJ
cord-300872-blycbi4u	227	3	activity	activity	NN
cord-300872-blycbi4u	227	4	of	of	IN
cord-300872-blycbi4u	227	5	these	these	DT
cord-300872-blycbi4u	227	6	new	new	JJ
cord-300872-blycbi4u	227	7	conjugates	conjugate	NNS
cord-300872-blycbi4u	227	8	against	against	IN
cord-300872-blycbi4u	227	9	four	four	CD
cord-300872-blycbi4u	227	10	phytopathogenic	phytopathogenic	JJ
cord-300872-blycbi4u	227	11	fungi	fungus	NNS
cord-300872-blycbi4u	227	12	(	(	-LRB-
cord-300872-blycbi4u	227	13	A.	A.	NNP
cord-300872-blycbi4u	227	14	alternate	alternate	JJ
cord-300872-blycbi4u	227	15	,	,	,
cord-300872-blycbi4u	227	16	A.	a.	NN
cord-300872-blycbi4u	227	17	solani	solani	NNS
cord-300872-blycbi4u	227	18	,	,	,
cord-300872-blycbi4u	227	19	B.	B.	NNP
cord-300872-blycbi4u	227	20	cinerea	cinerea	NN
cord-300872-blycbi4u	227	21	,	,	,
cord-300872-blycbi4u	227	22	and	and	CC
cord-300872-blycbi4u	227	23	F.	F.	NNP
cord-300872-blycbi4u	227	24	oxysporum	oxysporum	NNP
cord-300872-blycbi4u	227	25	)	)	-RRB-
cord-300872-blycbi4u	227	26	was	be	VBD
cord-300872-blycbi4u	227	27	evaluated	evaluate	VBN
cord-300872-blycbi4u	227	28	by	by	IN
cord-300872-blycbi4u	227	29	measuring	measure	VBG
cord-300872-blycbi4u	227	30	the	the	DT
cord-300872-blycbi4u	227	31	mycelial	mycelial	JJ
cord-300872-blycbi4u	227	32	inhibition	inhibition	NN
cord-300872-blycbi4u	227	33	of	of	IN
cord-300872-blycbi4u	227	34	radial	radial	JJ
cord-300872-blycbi4u	227	35	growth	growth	NN
cord-300872-blycbi4u	227	36	on	on	IN
cord-300872-blycbi4u	227	37	potato	potato	NN
cord-300872-blycbi4u	227	38	dextrose	dextrose	NN
cord-300872-blycbi4u	227	39	agar	agar	NN
cord-300872-blycbi4u	227	40	(	(	-LRB-
cord-300872-blycbi4u	227	41	PDA	pda	NN
cord-300872-blycbi4u	227	42	)	)	-RRB-
cord-300872-blycbi4u	227	43	media	medium	NNS
cord-300872-blycbi4u	227	44	compared	compare	VBN
cord-300872-blycbi4u	227	45	to	to	IN
cord-300872-blycbi4u	227	46	the	the	DT
cord-300872-blycbi4u	227	47	commercial	commercial	JJ
cord-300872-blycbi4u	227	48	fungicide	fungicide	NN
cord-300872-blycbi4u	227	49	carbendazim	carbendazim	NN
cord-300872-blycbi4u	227	50	.	.	.
cord-300872-blycbi4u	228	1	The	the	DT
cord-300872-blycbi4u	228	2	inhibition	inhibition	NN
cord-300872-blycbi4u	228	3	percentages	percentage	NNS
cord-300872-blycbi4u	228	4	of	of	IN
cord-300872-blycbi4u	228	5	radial	radial	JJ
cord-300872-blycbi4u	228	6	growth	growth	NN
cord-300872-blycbi4u	228	7	against	against	IN
cord-300872-blycbi4u	228	8	all	all	DT
cord-300872-blycbi4u	228	9	of	of	IN
cord-300872-blycbi4u	228	10	these	these	DT
cord-300872-blycbi4u	228	11	fungi	fungus	NNS
cord-300872-blycbi4u	228	12	for	for	IN
cord-300872-blycbi4u	228	13	umbelliferone-8-hydroxyquinoline	umbelliferone-8-hydroxyquinoline	NNP
cord-300872-blycbi4u	228	14	(	(	-LRB-
cord-300872-blycbi4u	228	15	n	n	NN
cord-300872-blycbi4u	228	16	=	=	SYM
cord-300872-blycbi4u	228	17	2	2	CD
cord-300872-blycbi4u	228	18	)	)	-RRB-
cord-300872-blycbi4u	228	19	,	,	,
cord-300872-blycbi4u	228	20	umbelliferone-8-hydroxyquinoline	umbelliferone-8-hydroxyquinoline	NNP
cord-300872-blycbi4u	228	21	(	(	-LRB-
cord-300872-blycbi4u	228	22	n	n	NN
cord-300872-blycbi4u	228	23	=	=	SYM
cord-300872-blycbi4u	228	24	4	4	CD
cord-300872-blycbi4u	228	25	)	)	-RRB-
cord-300872-blycbi4u	228	26	,	,	,
cord-300872-blycbi4u	228	27	and	and	CC
cord-300872-blycbi4u	228	28	umbelliferone-4-hydroxyquinoline	umbelliferone-4-hydroxyquinoline	JJ
cord-300872-blycbi4u	228	29	(	(	-LRB-
cord-300872-blycbi4u	228	30	n	n	NN
cord-300872-blycbi4u	228	31	=	=	SYM
cord-300872-blycbi4u	228	32	4	4	CD
cord-300872-blycbi4u	228	33	)	)	-RRB-
cord-300872-blycbi4u	228	34	were	be	VBD
cord-300872-blycbi4u	228	35	49	49	CD
cord-300872-blycbi4u	228	36	-	-	SYM
cord-300872-blycbi4u	228	37	63	63	CD
cord-300872-blycbi4u	228	38	,	,	,
cord-300872-blycbi4u	228	39	57	57	CD
cord-300872-blycbi4u	228	40	-	-	SYM
cord-300872-blycbi4u	228	41	90	90	CD
cord-300872-blycbi4u	228	42	,	,	,
cord-300872-blycbi4u	228	43	and	and	CC
cord-300872-blycbi4u	228	44	18	18	CD
cord-300872-blycbi4u	228	45	-	-	SYM
cord-300872-blycbi4u	228	46	41	41	CD
cord-300872-blycbi4u	228	47	%	%	NN
cord-300872-blycbi4u	228	48	,	,	,
cord-300872-blycbi4u	228	49	respectively	respectively	RB
cord-300872-blycbi4u	228	50	,	,	,
cord-300872-blycbi4u	228	51	compared	compare	VBN
cord-300872-blycbi4u	228	52	to	to	IN
cord-300872-blycbi4u	228	53	carbendazim	carbendazim	NN
cord-300872-blycbi4u	228	54	(	(	-LRB-
cord-300872-blycbi4u	228	55	95	95	CD
cord-300872-blycbi4u	228	56	-	-	SYM
cord-300872-blycbi4u	228	57	99	99	CD
cord-300872-blycbi4u	228	58	%	%	NN
cord-300872-blycbi4u	228	59	)	)	-RRB-
cord-300872-blycbi4u	228	60	at	at	IN
cord-300872-blycbi4u	228	61	200	200	CD
cord-300872-blycbi4u	228	62	µg	µg	NN
cord-300872-blycbi4u	228	63	/	/	SYM
cord-300872-blycbi4u	228	64	mL	ml	NN
cord-300872-blycbi4u	228	65	concentration	concentration	NN
cord-300872-blycbi4u	228	66	.	.	.
cord-300872-blycbi4u	229	1	When	when	WRB
cord-300872-blycbi4u	229	2	these	these	DT
cord-300872-blycbi4u	229	3	derivatives	derivative	NNS
cord-300872-blycbi4u	229	4	were	be	VBD
cord-300872-blycbi4u	229	5	tested	test	VBN
cord-300872-blycbi4u	229	6	at	at	IN
cord-300872-blycbi4u	229	7	a	a	DT
cord-300872-blycbi4u	229	8	series	series	NN
cord-300872-blycbi4u	229	9	of	of	IN
cord-300872-blycbi4u	229	10	lower	low	JJR
cord-300872-blycbi4u	229	11	concentrations	concentration	NNS
cord-300872-blycbi4u	229	12	to	to	TO
cord-300872-blycbi4u	229	13	measure	measure	VB
cord-300872-blycbi4u	229	14	the	the	DT
cord-300872-blycbi4u	229	15	half	half	RB
cord-300872-blycbi4u	229	16	-	-	HYPH
cord-300872-blycbi4u	229	17	maximal	maximal	JJ
cord-300872-blycbi4u	229	18	effective	effective	JJ
cord-300872-blycbi4u	229	19	concentration	concentration	NN
cord-300872-blycbi4u	229	20	(	(	-LRB-
cord-300872-blycbi4u	229	21	µg	µg	NN
cord-300872-blycbi4u	229	22	/	/	SYM
cord-300872-blycbi4u	229	23	mL	mL	NNP
cord-300872-blycbi4u	229	24	)	)	-RRB-
cord-300872-blycbi4u	229	25	,	,	,
cord-300872-blycbi4u	229	26	umbelliferone-8-hydroxyquinoline	umbelliferone-8-hydroxyquinoline	NNP
cord-300872-blycbi4u	229	27	(	(	-LRB-
cord-300872-blycbi4u	229	28	n	n	NN
cord-300872-blycbi4u	229	29	=	=	SYM
cord-300872-blycbi4u	229	30	4	4	CD
cord-300872-blycbi4u	229	31	)	)	-RRB-
cord-300872-blycbi4u	229	32	was	be	VBD
cord-300872-blycbi4u	229	33	the	the	DT
cord-300872-blycbi4u	229	34	most	most	RBS
cord-300872-blycbi4u	229	35	active	active	JJ
cord-300872-blycbi4u	229	36	compared	compare	VBN
cord-300872-blycbi4u	229	37	to	to	IN
cord-300872-blycbi4u	229	38	the	the	DT
cord-300872-blycbi4u	229	39	reference	reference	NN
cord-300872-blycbi4u	229	40	drug	drug	NN
cord-300872-blycbi4u	229	41	at	at	IN
cord-300872-blycbi4u	229	42	10.6	10.6	CD
cord-300872-blycbi4u	229	43	and	and	CC
cord-300872-blycbi4u	229	44	2.3	2.3	CD
cord-300872-blycbi4u	229	45	µg	µg	NN
cord-300872-blycbi4u	229	46	/	/	SYM
cord-300872-blycbi4u	229	47	mL	ml	NN
cord-300872-blycbi4u	229	48	,	,	,
cord-300872-blycbi4u	229	49	respectively	respectively	RB
cord-300872-blycbi4u	229	50	.	.	.
cord-300872-blycbi4u	230	1	The	the	DT
cord-300872-blycbi4u	230	2	rest	rest	NN
cord-300872-blycbi4u	230	3	of	of	IN
cord-300872-blycbi4u	230	4	the	the	DT
cord-300872-blycbi4u	230	5	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	230	6	derivatives	derivative	NNS
cord-300872-blycbi4u	230	7	exhibited	exhibit	VBD
cord-300872-blycbi4u	230	8	weak	weak	JJ
cord-300872-blycbi4u	230	9	activity	activity	NN
cord-300872-blycbi4u	230	10	.	.	.
cord-300872-blycbi4u	231	1	The	the	DT
cord-300872-blycbi4u	231	2	results	result	NNS
cord-300872-blycbi4u	231	3	also	also	RB
cord-300872-blycbi4u	231	4	showed	show	VBD
cord-300872-blycbi4u	231	5	that	that	IN
cord-300872-blycbi4u	231	6	umbelliferone	umbelliferone	JJ
cord-300872-blycbi4u	231	7	derivatives	derivative	NNS
cord-300872-blycbi4u	231	8	with	with	IN
cord-300872-blycbi4u	231	9	a	a	DT
cord-300872-blycbi4u	231	10	spacer	spacer	NN
cord-300872-blycbi4u	231	11	of	of	IN
cord-300872-blycbi4u	231	12	4	4	CD
cord-300872-blycbi4u	231	13	carbon	carbon	NN
cord-300872-blycbi4u	231	14	atoms	atom	NNS
cord-300872-blycbi4u	231	15	exhibit	exhibit	VBP
cord-300872-blycbi4u	231	16	better	well	JJR
cord-300872-blycbi4u	231	17	antifungal	antifungal	JJ
cord-300872-blycbi4u	231	18	activity	activity	NN
cord-300872-blycbi4u	231	19	than	than	IN
cord-300872-blycbi4u	231	20	those	those	DT
cord-300872-blycbi4u	231	21	with	with	IN
cord-300872-blycbi4u	231	22	a	a	DT
cord-300872-blycbi4u	231	23	spacer	spacer	NN
cord-300872-blycbi4u	231	24	of	of	IN
cord-300872-blycbi4u	231	25	2	2	CD
cord-300872-blycbi4u	231	26	carbon	carbon	NN
cord-300872-blycbi4u	231	27	atoms	atom	NNS
cord-300872-blycbi4u	231	28	.	.	.
cord-300872-blycbi4u	232	1	The	the	DT
cord-300872-blycbi4u	232	2	chain	chain	NN
cord-300872-blycbi4u	232	3	length	length	NN
cord-300872-blycbi4u	232	4	may	may	MD
cord-300872-blycbi4u	232	5	contribute	contribute	VB
cord-300872-blycbi4u	232	6	to	to	IN
cord-300872-blycbi4u	232	7	the	the	DT
cord-300872-blycbi4u	232	8	activity	activity	NN
cord-300872-blycbi4u	232	9	by	by	IN
cord-300872-blycbi4u	232	10	influencing	influence	VBG
cord-300872-blycbi4u	232	11	the	the	DT
cord-300872-blycbi4u	232	12	flexibility	flexibility	NN
cord-300872-blycbi4u	232	13	of	of	IN
cord-300872-blycbi4u	232	14	the	the	DT
cord-300872-blycbi4u	232	15	molecules	molecule	NNS
cord-300872-blycbi4u	232	16	.	.	.
cord-300872-blycbi4u	233	1	In	in	IN
cord-300872-blycbi4u	233	2	addition	addition	NN
cord-300872-blycbi4u	233	3	,	,	,
cord-300872-blycbi4u	233	4	the	the	DT
cord-300872-blycbi4u	233	5	position	position	NN
cord-300872-blycbi4u	233	6	of	of	IN
cord-300872-blycbi4u	233	7	the	the	DT
cord-300872-blycbi4u	233	8	OH	OH	NNP
cord-300872-blycbi4u	233	9	group	group	NN
cord-300872-blycbi4u	233	10	affects	affect	VBZ
cord-300872-blycbi4u	233	11	the	the	DT
cord-300872-blycbi4u	233	12	antifungal	antifungal	JJ
cord-300872-blycbi4u	233	13	activity	activity	NN
cord-300872-blycbi4u	233	14	;	;	:
cord-300872-blycbi4u	233	15	derivatives	derivative	NNS
cord-300872-blycbi4u	233	16	with	with	IN
cord-300872-blycbi4u	233	17	OH	OH	NNP
cord-300872-blycbi4u	233	18	at	at	IN
cord-300872-blycbi4u	233	19	position	position	NN
cord-300872-blycbi4u	233	20	8	8	CD
cord-300872-blycbi4u	233	21	were	be	VBD
cord-300872-blycbi4u	233	22	more	more	RBR
cord-300872-blycbi4u	233	23	active	active	JJ
cord-300872-blycbi4u	233	24	than	than	IN
cord-300872-blycbi4u	233	25	those	those	DT
cord-300872-blycbi4u	233	26	with	with	IN
cord-300872-blycbi4u	233	27	OH	OH	NNP
cord-300872-blycbi4u	233	28	at	at	IN
cord-300872-blycbi4u	233	29	position	position	NN
cord-300872-blycbi4u	233	30	4	4	CD
cord-300872-blycbi4u	233	31	.	.	.
cord-300872-blycbi4u	234	1	The	the	DT
cord-300872-blycbi4u	234	2	structure	structure	NN
cord-300872-blycbi4u	234	3	-	-	HYPH
cord-300872-blycbi4u	234	4	activity	activity	NN
cord-300872-blycbi4u	234	5	relationship	relationship	NN
cord-300872-blycbi4u	234	6	suggests	suggest	VBZ
cord-300872-blycbi4u	234	7	that	that	IN
cord-300872-blycbi4u	234	8	modification	modification	NN
cord-300872-blycbi4u	234	9	of	of	IN
cord-300872-blycbi4u	234	10	the	the	DT
cord-300872-blycbi4u	234	11	umbelliferone-8-hysroxyquinoline	umbelliferone-8-hysroxyquinoline	NNP
cord-300872-blycbi4u	234	12	analogues	analogue	NNS
cord-300872-blycbi4u	234	13	could	could	MD
cord-300872-blycbi4u	234	14	help	help	VB
cord-300872-blycbi4u	234	15	to	to	TO
cord-300872-blycbi4u	234	16	develop	develop	VB
cord-300872-blycbi4u	234	17	highly	highly	RB
cord-300872-blycbi4u	234	18	selective	selective	JJ
cord-300872-blycbi4u	234	19	and	and	CC
cord-300872-blycbi4u	234	20	low	low	JJ
cord-300872-blycbi4u	234	21	phytotoxic	phytotoxic	JJ
cord-300872-blycbi4u	234	22	fungicides	fungicide	NNS
cord-300872-blycbi4u	234	23	.	.	.
cord-300872-blycbi4u	235	1	The	the	DT
cord-300872-blycbi4u	235	2	phytotoxicity	phytotoxicity	NN
cord-300872-blycbi4u	235	3	of	of	IN
cord-300872-blycbi4u	235	4	effective	effective	JJ
cord-300872-blycbi4u	235	5	compounds	compound	NNS
cord-300872-blycbi4u	235	6	was	be	VBD
cord-300872-blycbi4u	235	7	evaluated	evaluate	VBN
cord-300872-blycbi4u	235	8	at	at	IN
cord-300872-blycbi4u	235	9	200	200	CD
cord-300872-blycbi4u	235	10	mg	mg	NNP
cord-300872-blycbi4u	235	11	/	/	SYM
cord-300872-blycbi4u	235	12	L	L	NNP
cord-300872-blycbi4u	235	13	with	with	IN
cord-300872-blycbi4u	235	14	L.	L.	NNP
cord-300872-blycbi4u	235	15	sativa	sativa	NN
cord-300872-blycbi4u	235	16	,	,	,
cord-300872-blycbi4u	235	17	with	with	IN
cord-300872-blycbi4u	235	18	the	the	DT
cord-300872-blycbi4u	235	19	results	result	NNS
cord-300872-blycbi4u	235	20	showing	show	VBG
cord-300872-blycbi4u	235	21	that	that	IN
cord-300872-blycbi4u	235	22	umbelliferone-8-hysroxyquinoline	umbelliferone-8-hysroxyquinoline	NNP
cord-300872-blycbi4u	235	23	(	(	-LRB-
cord-300872-blycbi4u	235	24	n	n	NN
cord-300872-blycbi4u	235	25	=	=	SYM
cord-300872-blycbi4u	235	26	4	4	CD
cord-300872-blycbi4u	235	27	)	)	-RRB-
cord-300872-blycbi4u	235	28	had	have	VBD
cord-300872-blycbi4u	235	29	no	no	DT
cord-300872-blycbi4u	235	30	phytotoxic	phytotoxic	JJ
cord-300872-blycbi4u	235	31	effects	effect	NNS
cord-300872-blycbi4u	235	32	on	on	IN
cord-300872-blycbi4u	235	33	the	the	DT
cord-300872-blycbi4u	235	34	seedling	seedling	NN
cord-300872-blycbi4u	235	35	growth	growth	NN
cord-300872-blycbi4u	235	36	of	of	IN
cord-300872-blycbi4u	235	37	lettuce	lettuce	NN
cord-300872-blycbi4u	235	38	.	.	.
cord-300872-blycbi4u	236	1	Yurras	Yurras	NNP
cord-300872-blycbi4u	236	2	and	and	CC
cord-300872-blycbi4u	236	3	coworkers	coworker	NNS
cord-300872-blycbi4u	236	4	have	have	VBP
cord-300872-blycbi4u	236	5	reported	report	VBN
cord-300872-blycbi4u	236	6	on	on	IN
cord-300872-blycbi4u	236	7	the	the	DT
cord-300872-blycbi4u	236	8	multistep	multistep	JJ
cord-300872-blycbi4u	236	9	synthesis	synthesis	NN
cord-300872-blycbi4u	236	10	of	of	IN
cord-300872-blycbi4u	236	11	novel	novel	JJ
cord-300872-blycbi4u	236	12	3,4,5-trisubstituted	3,4,5-trisubstituted	CD
cord-300872-blycbi4u	236	13	triazole	triazole	NN
cord-300872-blycbi4u	236	14	derivatives	derivative	NNS
cord-300872-blycbi4u	236	15	bearing	bear	VBG
cord-300872-blycbi4u	236	16	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	236	17	31	31	CD
cord-300872-blycbi4u	236	18	,	,	,
cord-300872-blycbi4u	236	19	evaluating	evaluate	VBG
cord-300872-blycbi4u	236	20	their	-PRON-	PRP$
cord-300872-blycbi4u	236	21	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	236	22	activity	activity	NN
cord-300872-blycbi4u	236	23	[	[	-LRB-
cord-300872-blycbi4u	236	24	15	15	CD
cord-300872-blycbi4u	236	25	]	]	-RRB-
cord-300872-blycbi4u	236	26	.	.	.
cord-300872-blycbi4u	237	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	237	2	was	be	VBD
cord-300872-blycbi4u	237	3	achieved	achieve	VBN
cord-300872-blycbi4u	237	4	by	by	IN
cord-300872-blycbi4u	237	5	first	first	RB
cord-300872-blycbi4u	237	6	reacting	react	VBG
cord-300872-blycbi4u	237	7	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	237	8	1	1	CD
cord-300872-blycbi4u	237	9	with	with	IN
cord-300872-blycbi4u	237	10	ethyl	ethyl	NN
cord-300872-blycbi4u	237	11	2-chloroacetate	2-chloroacetate	CD
cord-300872-blycbi4u	237	12	in	in	IN
cord-300872-blycbi4u	237	13	refluxing	refluxe	VBG
cord-300872-blycbi4u	237	14	acetone	acetone	NN
cord-300872-blycbi4u	237	15	in	in	IN
cord-300872-blycbi4u	237	16	the	the	DT
cord-300872-blycbi4u	237	17	presence	presence	NN
cord-300872-blycbi4u	237	18	of	of	IN
cord-300872-blycbi4u	237	19	a	a	DT
cord-300872-blycbi4u	237	20	base	base	NN
cord-300872-blycbi4u	237	21	.	.	.
cord-300872-blycbi4u	238	1	Treatment	treatment	NN
cord-300872-blycbi4u	238	2	of	of	IN
cord-300872-blycbi4u	238	3	the	the	DT
cord-300872-blycbi4u	238	4	formed	form	VBN
cord-300872-blycbi4u	238	5	ester	ester	NN
cord-300872-blycbi4u	238	6	26	26	CD
cord-300872-blycbi4u	238	7	with	with	IN
cord-300872-blycbi4u	238	8	hydrazine	hydrazine	NN
cord-300872-blycbi4u	238	9	hydrate	hydrate	NN
cord-300872-blycbi4u	238	10	in	in	IN
cord-300872-blycbi4u	238	11	ethanol	ethanol	NN
cord-300872-blycbi4u	238	12	followed	follow	VBN
cord-300872-blycbi4u	238	13	by	by	IN
cord-300872-blycbi4u	238	14	phenyl	phenyl	NN
cord-300872-blycbi4u	238	15	isocyanate	isocyanate	NN
cord-300872-blycbi4u	238	16	afforded	afford	VBD
cord-300872-blycbi4u	238	17	the	the	DT
cord-300872-blycbi4u	238	18	corresponding	correspond	VBG
cord-300872-blycbi4u	238	19	thiourea	thiourea	NN
cord-300872-blycbi4u	238	20	28	28	CD
cord-300872-blycbi4u	238	21	.	.	.
cord-300872-blycbi4u	239	1	Ring	ring	NN
cord-300872-blycbi4u	239	2	closure	closure	NN
cord-300872-blycbi4u	239	3	using	use	VBG
cord-300872-blycbi4u	239	4	KOH	KOH	NNP
cord-300872-blycbi4u	239	5	in	in	IN
cord-300872-blycbi4u	239	6	refluxing	refluxe	VBG
cord-300872-blycbi4u	239	7	ethanol	ethanol	NN
cord-300872-blycbi4u	239	8	led	lead	VBN
cord-300872-blycbi4u	239	9	to	to	IN
cord-300872-blycbi4u	239	10	the	the	DT
cord-300872-blycbi4u	239	11	formation	formation	NN
cord-300872-blycbi4u	239	12	of	of	IN
cord-300872-blycbi4u	239	13	3-mercapto-1,2,4-triazole	3-mercapto-1,2,4-triazole	CD
cord-300872-blycbi4u	239	14	derivative	derivative	JJ
cord-300872-blycbi4u	239	15	29	29	CD
cord-300872-blycbi4u	239	16	.	.	.
cord-300872-blycbi4u	240	1	Reaction	reaction	NN
cord-300872-blycbi4u	240	2	of	of	IN
cord-300872-blycbi4u	240	3	3-mercapto-1,2,4-triazole	3-mercapto-1,2,4-triazole	CD
cord-300872-blycbi4u	240	4	with	with	IN
cord-300872-blycbi4u	240	5	2-chloro	2-chloro	CD
cord-300872-blycbi4u	240	6	-	-	HYPH
cord-300872-blycbi4u	240	7	N-(substituted	n-(substituted	JJ
cord-300872-blycbi4u	240	8	(	(	-LRB-
cord-300872-blycbi4u	240	9	benzo)/thiazole)acetamide	benzo)/thiazole)acetamide	NNP
cord-300872-blycbi4u	240	10	30	30	CD
cord-300872-blycbi4u	240	11	afforded	afford	VBD
cord-300872-blycbi4u	240	12	the	the	DT
cord-300872-blycbi4u	240	13	target	target	NN
cord-300872-blycbi4u	240	14	compounds	compound	NNS
cord-300872-blycbi4u	240	15	,	,	,
cord-300872-blycbi4u	240	16	as	as	IN
cord-300872-blycbi4u	240	17	depicted	depict	VBN
cord-300872-blycbi4u	240	18	in	in	IN
cord-300872-blycbi4u	240	19	Scheme	Scheme	NNP
cord-300872-blycbi4u	240	20	9	9	CD
cord-300872-blycbi4u	240	21	.	.	.
cord-300872-blycbi4u	241	1	Molecules	molecule	NNS
cord-300872-blycbi4u	241	2	2020	2020	CD
cord-300872-blycbi4u	241	3	,	,	,
cord-300872-blycbi4u	241	4	25	25	CD
cord-300872-blycbi4u	241	5	,	,	,
cord-300872-blycbi4u	241	6	x	x	NN
cord-300872-blycbi4u	241	7	FOR	for	IN
cord-300872-blycbi4u	241	8	PEER	PEER	NNP
cord-300872-blycbi4u	241	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	241	10	8	8	CD
cord-300872-blycbi4u	241	11	of	of	IN
cord-300872-blycbi4u	241	12	26	26	CD
cord-300872-blycbi4u	241	13	activity	activity	NN
cord-300872-blycbi4u	241	14	than	than	IN
cord-300872-blycbi4u	241	15	those	those	DT
cord-300872-blycbi4u	241	16	with	with	IN
cord-300872-blycbi4u	241	17	a	a	DT
cord-300872-blycbi4u	241	18	spacer	spacer	NN
cord-300872-blycbi4u	241	19	of	of	IN
cord-300872-blycbi4u	241	20	2	2	CD
cord-300872-blycbi4u	241	21	carbon	carbon	NN
cord-300872-blycbi4u	241	22	atoms	atom	NNS
cord-300872-blycbi4u	241	23	.	.	.
cord-300872-blycbi4u	242	1	The	the	DT
cord-300872-blycbi4u	242	2	chain	chain	NN
cord-300872-blycbi4u	242	3	length	length	NN
cord-300872-blycbi4u	242	4	may	may	MD
cord-300872-blycbi4u	242	5	contribute	contribute	VB
cord-300872-blycbi4u	242	6	to	to	IN
cord-300872-blycbi4u	242	7	the	the	DT
cord-300872-blycbi4u	242	8	activity	activity	NN
cord-300872-blycbi4u	242	9	by	by	IN
cord-300872-blycbi4u	242	10	influencing	influence	VBG
cord-300872-blycbi4u	242	11	the	the	DT
cord-300872-blycbi4u	242	12	flexibility	flexibility	NN
cord-300872-blycbi4u	242	13	of	of	IN
cord-300872-blycbi4u	242	14	the	the	DT
cord-300872-blycbi4u	242	15	molecules	molecule	NNS
cord-300872-blycbi4u	242	16	.	.	.
cord-300872-blycbi4u	243	1	In	in	IN
cord-300872-blycbi4u	243	2	addition	addition	NN
cord-300872-blycbi4u	243	3	,	,	,
cord-300872-blycbi4u	243	4	the	the	DT
cord-300872-blycbi4u	243	5	position	position	NN
cord-300872-blycbi4u	243	6	of	of	IN
cord-300872-blycbi4u	243	7	the	the	DT
cord-300872-blycbi4u	243	8	OH	OH	NNP
cord-300872-blycbi4u	243	9	group	group	NN
cord-300872-blycbi4u	243	10	affects	affect	VBZ
cord-300872-blycbi4u	243	11	the	the	DT
cord-300872-blycbi4u	243	12	antifungal	antifungal	JJ
cord-300872-blycbi4u	243	13	activity	activity	NN
cord-300872-blycbi4u	243	14	;	;	:
cord-300872-blycbi4u	243	15	derivatives	derivative	NNS
cord-300872-blycbi4u	243	16	with	with	IN
cord-300872-blycbi4u	243	17	OH	OH	NNP
cord-300872-blycbi4u	243	18	at	at	IN
cord-300872-blycbi4u	243	19	position	position	NN
cord-300872-blycbi4u	243	20	8	8	CD
cord-300872-blycbi4u	243	21	were	be	VBD
cord-300872-blycbi4u	243	22	more	more	RBR
cord-300872-blycbi4u	243	23	active	active	JJ
cord-300872-blycbi4u	243	24	than	than	IN
cord-300872-blycbi4u	243	25	those	those	DT
cord-300872-blycbi4u	243	26	with	with	IN
cord-300872-blycbi4u	243	27	OH	OH	NNP
cord-300872-blycbi4u	243	28	at	at	IN
cord-300872-blycbi4u	243	29	position	position	NN
cord-300872-blycbi4u	243	30	4	4	CD
cord-300872-blycbi4u	243	31	.	.	.
cord-300872-blycbi4u	244	1	The	the	DT
cord-300872-blycbi4u	244	2	structure	structure	NN
cord-300872-blycbi4u	244	3	-	-	HYPH
cord-300872-blycbi4u	244	4	activity	activity	NN
cord-300872-blycbi4u	244	5	relationship	relationship	NN
cord-300872-blycbi4u	244	6	suggests	suggest	VBZ
cord-300872-blycbi4u	244	7	that	that	IN
cord-300872-blycbi4u	244	8	modification	modification	NN
cord-300872-blycbi4u	244	9	of	of	IN
cord-300872-blycbi4u	244	10	the	the	DT
cord-300872-blycbi4u	244	11	umbelliferone-8hysroxyquinoline	umbelliferone-8hysroxyquinoline	JJ
cord-300872-blycbi4u	244	12	analogues	analogue	NNS
cord-300872-blycbi4u	244	13	could	could	MD
cord-300872-blycbi4u	244	14	help	help	VB
cord-300872-blycbi4u	244	15	to	to	TO
cord-300872-blycbi4u	244	16	develop	develop	VB
cord-300872-blycbi4u	244	17	highly	highly	RB
cord-300872-blycbi4u	244	18	selective	selective	JJ
cord-300872-blycbi4u	244	19	and	and	CC
cord-300872-blycbi4u	244	20	low	low	JJ
cord-300872-blycbi4u	244	21	phytotoxic	phytotoxic	JJ
cord-300872-blycbi4u	244	22	fungicides	fungicide	NNS
cord-300872-blycbi4u	244	23	.	.	.
cord-300872-blycbi4u	245	1	The	the	DT
cord-300872-blycbi4u	245	2	phytotoxicity	phytotoxicity	NN
cord-300872-blycbi4u	245	3	of	of	IN
cord-300872-blycbi4u	245	4	effective	effective	JJ
cord-300872-blycbi4u	245	5	compounds	compound	NNS
cord-300872-blycbi4u	245	6	was	be	VBD
cord-300872-blycbi4u	245	7	evaluated	evaluate	VBN
cord-300872-blycbi4u	245	8	at	at	IN
cord-300872-blycbi4u	245	9	200	200	CD
cord-300872-blycbi4u	245	10	mg	mg	NNP
cord-300872-blycbi4u	245	11	/	/	SYM
cord-300872-blycbi4u	245	12	L	L	NNP
cord-300872-blycbi4u	245	13	with	with	IN
cord-300872-blycbi4u	245	14	L.	L.	NNP
cord-300872-blycbi4u	245	15	sativa	sativa	NN
cord-300872-blycbi4u	245	16	,	,	,
cord-300872-blycbi4u	245	17	with	with	IN
cord-300872-blycbi4u	245	18	the	the	DT
cord-300872-blycbi4u	245	19	results	result	NNS
cord-300872-blycbi4u	245	20	showing	show	VBG
cord-300872-blycbi4u	245	21	that	that	IN
cord-300872-blycbi4u	245	22	umbelliferone-8-hysroxyquinoline	umbelliferone-8-hysroxyquinoline	NNP
cord-300872-blycbi4u	245	23	(	(	-LRB-
cord-300872-blycbi4u	245	24	n	n	NN
cord-300872-blycbi4u	245	25	=	=	SYM
cord-300872-blycbi4u	245	26	4	4	CD
cord-300872-blycbi4u	245	27	)	)	-RRB-
cord-300872-blycbi4u	245	28	had	have	VBD
cord-300872-blycbi4u	245	29	no	no	DT
cord-300872-blycbi4u	245	30	phytotoxic	phytotoxic	JJ
cord-300872-blycbi4u	245	31	effects	effect	NNS
cord-300872-blycbi4u	245	32	on	on	IN
cord-300872-blycbi4u	245	33	the	the	DT
cord-300872-blycbi4u	245	34	seedling	seedling	NN
cord-300872-blycbi4u	245	35	growth	growth	NN
cord-300872-blycbi4u	245	36	of	of	IN
cord-300872-blycbi4u	245	37	lettuce	lettuce	NN
cord-300872-blycbi4u	245	38	.	.	.
cord-300872-blycbi4u	246	1	Yurras	Yurras	NNP
cord-300872-blycbi4u	246	2	and	and	CC
cord-300872-blycbi4u	246	3	coworkers	coworker	NNS
cord-300872-blycbi4u	246	4	have	have	VBP
cord-300872-blycbi4u	246	5	reported	report	VBN
cord-300872-blycbi4u	246	6	on	on	IN
cord-300872-blycbi4u	246	7	the	the	DT
cord-300872-blycbi4u	246	8	multistep	multistep	JJ
cord-300872-blycbi4u	246	9	synthesis	synthesis	NN
cord-300872-blycbi4u	246	10	of	of	IN
cord-300872-blycbi4u	246	11	novel	novel	JJ
cord-300872-blycbi4u	246	12	3,4,5-trisubstituted	3,4,5-trisubstituted	CD
cord-300872-blycbi4u	246	13	triazole	triazole	NN
cord-300872-blycbi4u	246	14	derivatives	derivative	NNS
cord-300872-blycbi4u	246	15	bearing	bear	VBG
cord-300872-blycbi4u	246	16	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	246	17	31	31	CD
cord-300872-blycbi4u	246	18	,	,	,
cord-300872-blycbi4u	246	19	evaluating	evaluate	VBG
cord-300872-blycbi4u	246	20	their	-PRON-	PRP$
cord-300872-blycbi4u	246	21	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	246	22	activity	activity	NN
cord-300872-blycbi4u	246	23	[	[	-LRB-
cord-300872-blycbi4u	246	24	15	15	CD
cord-300872-blycbi4u	246	25	]	]	-RRB-
cord-300872-blycbi4u	246	26	.	.	.
cord-300872-blycbi4u	247	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	247	2	was	be	VBD
cord-300872-blycbi4u	247	3	achieved	achieve	VBN
cord-300872-blycbi4u	247	4	by	by	IN
cord-300872-blycbi4u	247	5	first	first	RB
cord-300872-blycbi4u	247	6	reacting	react	VBG
cord-300872-blycbi4u	247	7	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	247	8	1	1	CD
cord-300872-blycbi4u	247	9	with	with	IN
cord-300872-blycbi4u	247	10	ethyl	ethyl	NN
cord-300872-blycbi4u	247	11	2-chloroacetate	2-chloroacetate	CD
cord-300872-blycbi4u	247	12	in	in	IN
cord-300872-blycbi4u	247	13	refluxing	refluxe	VBG
cord-300872-blycbi4u	247	14	acetone	acetone	NN
cord-300872-blycbi4u	247	15	in	in	IN
cord-300872-blycbi4u	247	16	the	the	DT
cord-300872-blycbi4u	247	17	presence	presence	NN
cord-300872-blycbi4u	247	18	of	of	IN
cord-300872-blycbi4u	247	19	a	a	DT
cord-300872-blycbi4u	247	20	base	base	NN
cord-300872-blycbi4u	247	21	.	.	.
cord-300872-blycbi4u	248	1	Treatment	treatment	NN
cord-300872-blycbi4u	248	2	of	of	IN
cord-300872-blycbi4u	248	3	the	the	DT
cord-300872-blycbi4u	248	4	formed	form	VBN
cord-300872-blycbi4u	248	5	ester	ester	NN
cord-300872-blycbi4u	248	6	26	26	CD
cord-300872-blycbi4u	248	7	with	with	IN
cord-300872-blycbi4u	248	8	hydrazine	hydrazine	NN
cord-300872-blycbi4u	248	9	hydrate	hydrate	NN
cord-300872-blycbi4u	248	10	in	in	IN
cord-300872-blycbi4u	248	11	ethanol	ethanol	NN
cord-300872-blycbi4u	248	12	followed	follow	VBN
cord-300872-blycbi4u	248	13	by	by	IN
cord-300872-blycbi4u	248	14	phenyl	phenyl	NN
cord-300872-blycbi4u	248	15	isocyanate	isocyanate	NN
cord-300872-blycbi4u	248	16	afforded	afford	VBD
cord-300872-blycbi4u	248	17	the	the	DT
cord-300872-blycbi4u	248	18	corresponding	correspond	VBG
cord-300872-blycbi4u	248	19	thiourea	thiourea	NN
cord-300872-blycbi4u	248	20	28	28	CD
cord-300872-blycbi4u	248	21	.	.	.
cord-300872-blycbi4u	249	1	Ring	ring	NN
cord-300872-blycbi4u	249	2	closure	closure	NN
cord-300872-blycbi4u	249	3	using	use	VBG
cord-300872-blycbi4u	249	4	KOH	KOH	NNP
cord-300872-blycbi4u	249	5	in	in	IN
cord-300872-blycbi4u	249	6	refluxing	refluxe	VBG
cord-300872-blycbi4u	249	7	ethanol	ethanol	NN
cord-300872-blycbi4u	249	8	led	lead	VBN
cord-300872-blycbi4u	249	9	to	to	IN
cord-300872-blycbi4u	249	10	the	the	DT
cord-300872-blycbi4u	249	11	formation	formation	NN
cord-300872-blycbi4u	249	12	of	of	IN
cord-300872-blycbi4u	249	13	3-mercapto-1,2,4-triazole	3-mercapto-1,2,4-triazole	CD
cord-300872-blycbi4u	249	14	derivative	derivative	JJ
cord-300872-blycbi4u	249	15	29	29	CD
cord-300872-blycbi4u	249	16	.	.	.
cord-300872-blycbi4u	250	1	Reaction	reaction	NN
cord-300872-blycbi4u	250	2	of	of	IN
cord-300872-blycbi4u	250	3	3mercapto-1,2,4-triazole	3mercapto-1,2,4-triazole	CD
cord-300872-blycbi4u	250	4	with	with	IN
cord-300872-blycbi4u	250	5	2-chloro	2-chloro	CD
cord-300872-blycbi4u	250	6	-	-	HYPH
cord-300872-blycbi4u	250	7	N-(substituted	n-(substituted	JJ
cord-300872-blycbi4u	250	8	(	(	-LRB-
cord-300872-blycbi4u	250	9	benzo)/thiazole)acetamide	benzo)/thiazole)acetamide	NNP
cord-300872-blycbi4u	250	10	30	30	CD
cord-300872-blycbi4u	250	11	afforded	afford	VBD
cord-300872-blycbi4u	250	12	the	the	DT
cord-300872-blycbi4u	250	13	target	target	NN
cord-300872-blycbi4u	250	14	compounds	compound	NNS
cord-300872-blycbi4u	250	15	,	,	,
cord-300872-blycbi4u	250	16	as	as	IN
cord-300872-blycbi4u	250	17	depicted	depict	VBN
cord-300872-blycbi4u	250	18	in	in	IN
cord-300872-blycbi4u	250	19	Scheme	Scheme	NNP
cord-300872-blycbi4u	250	20	9	9	CD
cord-300872-blycbi4u	250	21	.	.	.
cord-300872-blycbi4u	251	1	Some	some	DT
cord-300872-blycbi4u	251	2	sulfonates	sulfonate	NNS
cord-300872-blycbi4u	251	3	reported	report	VBN
cord-300872-blycbi4u	251	4	by	by	IN
cord-300872-blycbi4u	251	5	Krishna	Krishna	NNP
cord-300872-blycbi4u	251	6	(	(	-LRB-
cord-300872-blycbi4u	251	7	Scheme	Scheme	NNP
cord-300872-blycbi4u	251	8	4	4	CD
cord-300872-blycbi4u	251	9	)	)	-RRB-
cord-300872-blycbi4u	251	10	were	be	VBD
cord-300872-blycbi4u	251	11	also	also	RB
cord-300872-blycbi4u	251	12	tested	test	VBN
cord-300872-blycbi4u	251	13	in	in	IN
cord-300872-blycbi4u	251	14	vitro	vitro	FW
cord-300872-blycbi4u	251	15	against	against	IN
cord-300872-blycbi4u	251	16	Aspergillus	Aspergillus	NNP
cord-300872-blycbi4u	251	17	niger	niger	NNP
cord-300872-blycbi4u	251	18	and	and	CC
cord-300872-blycbi4u	251	19	Penicillium	Penicillium	NNP
cord-300872-blycbi4u	251	20	spinulosum	spinulosum	NN
cord-300872-blycbi4u	251	21	fungal	fungal	NN
cord-300872-blycbi4u	251	22	strains	strain	NNS
cord-300872-blycbi4u	251	23	by	by	IN
cord-300872-blycbi4u	251	24	the	the	DT
cord-300872-blycbi4u	251	25	poison	poison	NN
cord-300872-blycbi4u	251	26	plate	plate	NN
cord-300872-blycbi4u	251	27	technique	technique	NN
cord-300872-blycbi4u	251	28	;	;	:
cord-300872-blycbi4u	251	29	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	251	30	was	be	VBD
cord-300872-blycbi4u	251	31	used	use	VBN
cord-300872-blycbi4u	251	32	as	as	IN
cord-300872-blycbi4u	251	33	a	a	DT
cord-300872-blycbi4u	251	34	standard	standard	JJ
cord-300872-blycbi4u	251	35	drug	drug	NN
cord-300872-blycbi4u	251	36	for	for	IN
cord-300872-blycbi4u	251	37	antifungal	antifungal	JJ
cord-300872-blycbi4u	251	38	activity	activity	NN
cord-300872-blycbi4u	251	39	.	.	.
cord-300872-blycbi4u	252	1	Two	two	CD
cord-300872-blycbi4u	252	2	compounds	compound	NNS
cord-300872-blycbi4u	252	3	with	with	IN
cord-300872-blycbi4u	252	4	Ar	ar	NN
cord-300872-blycbi4u	252	5	=	=	SYM
cord-300872-blycbi4u	252	6	biphenyl	biphenyl	NN
cord-300872-blycbi4u	252	7	and	and	CC
cord-300872-blycbi4u	252	8	Ar	Ar	NNP
cord-300872-blycbi4u	252	9	=	=	SYM
cord-300872-blycbi4u	252	10	2-nitro-5-hydroxybenzene	2-nitro-5-hydroxybenzene	CD
cord-300872-blycbi4u	252	11	exhibited	exhibit	VBD
cord-300872-blycbi4u	252	12	the	the	DT
cord-300872-blycbi4u	252	13	most	most	RBS
cord-300872-blycbi4u	252	14	potent	potent	JJ
cord-300872-blycbi4u	252	15	antifungal	antifungal	JJ
cord-300872-blycbi4u	252	16	activity	activity	NN
cord-300872-blycbi4u	252	17	against	against	IN
cord-300872-blycbi4u	252	18	Aspergillus	Aspergillus	NNP
cord-300872-blycbi4u	252	19	niger	niger	NNP
cord-300872-blycbi4u	252	20	,	,	,
cord-300872-blycbi4u	252	21	with	with	IN
cord-300872-blycbi4u	252	22	inhibition	inhibition	NN
cord-300872-blycbi4u	252	23	zones	zone	NNS
cord-300872-blycbi4u	252	24	of	of	IN
cord-300872-blycbi4u	252	25	10	10	CD
cord-300872-blycbi4u	252	26	and	and	CC
cord-300872-blycbi4u	252	27	13	13	CD
cord-300872-blycbi4u	252	28	mm	mm	NNS
cord-300872-blycbi4u	252	29	,	,	,
cord-300872-blycbi4u	252	30	respectively	respectively	RB
cord-300872-blycbi4u	252	31	,	,	,
cord-300872-blycbi4u	252	32	compared	compare	VBN
cord-300872-blycbi4u	252	33	to	to	IN
cord-300872-blycbi4u	252	34	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	252	35	(	(	-LRB-
cord-300872-blycbi4u	252	36	15	15	CD
cord-300872-blycbi4u	252	37	mm	mm	NN
cord-300872-blycbi4u	252	38	)	)	-RRB-
cord-300872-blycbi4u	252	39	;	;	:
cord-300872-blycbi4u	252	40	and	and	CC
cord-300872-blycbi4u	252	41	against	against	IN
cord-300872-blycbi4u	252	42	Penicillium	Penicillium	NNP
cord-300872-blycbi4u	252	43	spinulosum	spinulosum	NNP
cord-300872-blycbi4u	252	44	,	,	,
cord-300872-blycbi4u	252	45	with	with	IN
cord-300872-blycbi4u	252	46	inhibition	inhibition	NN
cord-300872-blycbi4u	252	47	zones	zone	NNS
cord-300872-blycbi4u	252	48	of	of	IN
cord-300872-blycbi4u	252	49	12	12	CD
cord-300872-blycbi4u	252	50	and	and	CC
cord-300872-blycbi4u	252	51	10	10	CD
cord-300872-blycbi4u	252	52	mm	mm	NNS
cord-300872-blycbi4u	252	53	,	,	,
cord-300872-blycbi4u	252	54	respectively	respectively	RB
cord-300872-blycbi4u	252	55	,	,	,
cord-300872-blycbi4u	252	56	compared	compare	VBN
cord-300872-blycbi4u	252	57	to	to	IN
cord-300872-blycbi4u	252	58	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	252	59	(	(	-LRB-
cord-300872-blycbi4u	252	60	12	12	CD
cord-300872-blycbi4u	252	61	mm	mm	NN
cord-300872-blycbi4u	252	62	)	)	-RRB-
cord-300872-blycbi4u	252	63	.	.	.
cord-300872-blycbi4u	253	1	Cancer	cancer	NN
cord-300872-blycbi4u	253	2	is	be	VBZ
cord-300872-blycbi4u	253	3	a	a	DT
cord-300872-blycbi4u	253	4	dreadful	dreadful	JJ
cord-300872-blycbi4u	253	5	disease	disease	NN
cord-300872-blycbi4u	253	6	that	that	WDT
cord-300872-blycbi4u	253	7	has	have	VBZ
cord-300872-blycbi4u	253	8	become	become	VBN
cord-300872-blycbi4u	253	9	a	a	DT
cord-300872-blycbi4u	253	10	global	global	JJ
cord-300872-blycbi4u	253	11	burden	burden	NN
cord-300872-blycbi4u	253	12	,	,	,
cord-300872-blycbi4u	253	13	causing	cause	VBG
cord-300872-blycbi4u	253	14	thousands	thousand	NNS
cord-300872-blycbi4u	253	15	of	of	IN
cord-300872-blycbi4u	253	16	deaths	death	NNS
cord-300872-blycbi4u	253	17	per	per	IN
cord-300872-blycbi4u	253	18	year	year	NN
cord-300872-blycbi4u	253	19	,	,	,
cord-300872-blycbi4u	253	20	despite	despite	IN
cord-300872-blycbi4u	253	21	the	the	DT
cord-300872-blycbi4u	253	22	technological	technological	JJ
cord-300872-blycbi4u	253	23	and	and	CC
cord-300872-blycbi4u	253	24	pharmaceutical	pharmaceutical	JJ
cord-300872-blycbi4u	253	25	improvements	improvement	NNS
cord-300872-blycbi4u	253	26	over	over	IN
cord-300872-blycbi4u	253	27	the	the	DT
cord-300872-blycbi4u	253	28	past	past	JJ
cord-300872-blycbi4u	253	29	several	several	JJ
cord-300872-blycbi4u	253	30	years	year	NNS
cord-300872-blycbi4u	253	31	.	.	.
cord-300872-blycbi4u	254	1	It	-PRON-	PRP
cord-300872-blycbi4u	254	2	has	have	VBZ
cord-300872-blycbi4u	254	3	emerged	emerge	VBN
cord-300872-blycbi4u	254	4	as	as	IN
cord-300872-blycbi4u	254	5	one	one	CD
cord-300872-blycbi4u	254	6	of	of	IN
cord-300872-blycbi4u	254	7	the	the	DT
cord-300872-blycbi4u	254	8	leading	lead	VBG
cord-300872-blycbi4u	254	9	causes	cause	NNS
cord-300872-blycbi4u	254	10	of	of	IN
cord-300872-blycbi4u	254	11	mortality	mortality	NN
cord-300872-blycbi4u	254	12	worldwide	worldwide	RB
cord-300872-blycbi4u	254	13	[	[	-LRB-
cord-300872-blycbi4u	254	14	16	16	CD
cord-300872-blycbi4u	254	15	]	]	-RRB-
cord-300872-blycbi4u	254	16	.	.	.
cord-300872-blycbi4u	255	1	Cancer	cancer	NN
cord-300872-blycbi4u	255	2	treatments	treatment	NNS
cord-300872-blycbi4u	255	3	include	include	VBP
cord-300872-blycbi4u	255	4	surgery	surgery	NN
cord-300872-blycbi4u	255	5	,	,	,
cord-300872-blycbi4u	255	6	radiotherapy	radiotherapy	NN
cord-300872-blycbi4u	255	7	,	,	,
cord-300872-blycbi4u	255	8	and	and	CC
cord-300872-blycbi4u	255	9	anticancer	anticancer	JJ
cord-300872-blycbi4u	255	10	drugs	drug	NNS
cord-300872-blycbi4u	255	11	(	(	-LRB-
cord-300872-blycbi4u	255	12	chemotherapy	chemotherapy	NN
cord-300872-blycbi4u	255	13	)	)	-RRB-
cord-300872-blycbi4u	255	14	,	,	,
cord-300872-blycbi4u	255	15	in	in	IN
cord-300872-blycbi4u	255	16	addition	addition	NN
cord-300872-blycbi4u	255	17	to	to	IN
cord-300872-blycbi4u	255	18	other	other	JJ
cord-300872-blycbi4u	255	19	specialized	specialized	JJ
cord-300872-blycbi4u	255	20	techniques	technique	NNS
cord-300872-blycbi4u	255	21	.	.	.
cord-300872-blycbi4u	256	1	Much	much	JJ
cord-300872-blycbi4u	256	2	scientific	scientific	JJ
cord-300872-blycbi4u	256	3	effort	effort	NN
cord-300872-blycbi4u	256	4	is	be	VBZ
cord-300872-blycbi4u	256	5	being	be	VBG
cord-300872-blycbi4u	256	6	made	make	VBN
cord-300872-blycbi4u	256	7	every	every	DT
cord-300872-blycbi4u	256	8	day	day	NN
cord-300872-blycbi4u	256	9	in	in	IN
cord-300872-blycbi4u	256	10	the	the	DT
cord-300872-blycbi4u	256	11	fight	fight	NN
cord-300872-blycbi4u	256	12	against	against	IN
cord-300872-blycbi4u	256	13	cancer	cancer	NN
cord-300872-blycbi4u	256	14	,	,	,
cord-300872-blycbi4u	256	15	but	but	CC
cord-300872-blycbi4u	256	16	successful	successful	JJ
cord-300872-blycbi4u	256	17	treatment	treatment	NN
cord-300872-blycbi4u	256	18	of	of	IN
cord-300872-blycbi4u	256	19	some	some	DT
cord-300872-blycbi4u	256	20	cancer	cancer	NN
cord-300872-blycbi4u	256	21	types	type	NNS
cord-300872-blycbi4u	256	22	is	be	VBZ
cord-300872-blycbi4u	256	23	still	still	RB
cord-300872-blycbi4u	256	24	a	a	DT
cord-300872-blycbi4u	256	25	challenge	challenge	NN
cord-300872-blycbi4u	256	26	that	that	WDT
cord-300872-blycbi4u	256	27	needs	need	VBZ
cord-300872-blycbi4u	256	28	more	more	JJR
cord-300872-blycbi4u	256	29	work	work	NN
cord-300872-blycbi4u	256	30	[	[	-LRB-
cord-300872-blycbi4u	256	31	17	17	CD
cord-300872-blycbi4u	256	32	]	]	-RRB-
cord-300872-blycbi4u	256	33	.	.	.
cord-300872-blycbi4u	257	1	On	on	IN
cord-300872-blycbi4u	257	2	the	the	DT
cord-300872-blycbi4u	257	3	synthetic	synthetic	JJ
cord-300872-blycbi4u	257	4	front	front	NN
cord-300872-blycbi4u	257	5	in	in	IN
cord-300872-blycbi4u	257	6	the	the	DT
cord-300872-blycbi4u	257	7	fight	fight	NN
cord-300872-blycbi4u	257	8	against	against	IN
cord-300872-blycbi4u	257	9	cancer	cancer	NN
cord-300872-blycbi4u	257	10	,	,	,
cord-300872-blycbi4u	257	11	two	two	CD
cord-300872-blycbi4u	257	12	new	new	JJ
cord-300872-blycbi4u	257	13	series	series	NN
cord-300872-blycbi4u	257	14	of	of	IN
cord-300872-blycbi4u	257	15	derivatives	derivative	NNS
cord-300872-blycbi4u	257	16	have	have	VBP
cord-300872-blycbi4u	257	17	been	be	VBN
cord-300872-blycbi4u	257	18	prepared	prepare	VBN
cord-300872-blycbi4u	257	19	where	where	WRB
cord-300872-blycbi4u	257	20	the	the	DT
cord-300872-blycbi4u	257	21	bioactive	bioactive	JJ
cord-300872-blycbi4u	257	22	quinolone	quinolone	NNP
cord-300872-blycbi4u	257	23	motif	motif	NN
cord-300872-blycbi4u	257	24	is	be	VBZ
cord-300872-blycbi4u	257	25	incorporated	incorporate	VBN
cord-300872-blycbi4u	257	26	,	,	,
cord-300872-blycbi4u	257	27	as	as	IN
cord-300872-blycbi4u	257	28	shown	show	VBN
cord-300872-blycbi4u	257	29	in	in	IN
cord-300872-blycbi4u	257	30	Scheme	Scheme	NNP
cord-300872-blycbi4u	257	31	10	10	CD
cord-300872-blycbi4u	257	32	[	[	-LRB-
cord-300872-blycbi4u	257	33	18	18	CD
cord-300872-blycbi4u	257	34	]	]	-RRB-
cord-300872-blycbi4u	257	35	.	.	.
cord-300872-blycbi4u	258	1	6-Bromo-8-methoxyquinoline	6-bromo-8-methoxyquinoline	CD
cord-300872-blycbi4u	259	1	(	(	-LRB-
cord-300872-blycbi4u	259	2	1	1	LS
cord-300872-blycbi4u	259	3	)	)	-RRB-
cord-300872-blycbi4u	259	4	was	be	VBD
cord-300872-blycbi4u	259	5	prepared	prepare	VBN
cord-300872-blycbi4u	259	6	according	accord	VBG
cord-300872-blycbi4u	259	7	to	to	IN
cord-300872-blycbi4u	259	8	a	a	DT
cord-300872-blycbi4u	259	9	published	publish	VBN
cord-300872-blycbi4u	259	10	procedure	procedure	NN
cord-300872-blycbi4u	259	11	[	[	-LRB-
cord-300872-blycbi4u	259	12	19	19	CD
cord-300872-blycbi4u	259	13	]	]	-RRB-
cord-300872-blycbi4u	259	14	.	.	.
cord-300872-blycbi4u	260	1	Afterwards	afterwards	RB
cord-300872-blycbi4u	260	2	,	,	,
cord-300872-blycbi4u	260	3	compound	compound	NN
cord-300872-blycbi4u	260	4	32	32	CD
cord-300872-blycbi4u	260	5	was	be	VBD
cord-300872-blycbi4u	260	6	subjected	subject	VBN
cord-300872-blycbi4u	260	7	to	to	IN
cord-300872-blycbi4u	260	8	a	a	DT
cord-300872-blycbi4u	260	9	Suzuki	Suzuki	NNP
cord-300872-blycbi4u	260	10	cross	cross	JJ
cord-300872-blycbi4u	260	11	-	-	JJ
cord-300872-blycbi4u	260	12	coupling	coupling	JJ
cord-300872-blycbi4u	260	13	reaction	reaction	NN
cord-300872-blycbi4u	260	14	with	with	IN
cord-300872-blycbi4u	260	15	p	p	NN
cord-300872-blycbi4u	260	16	-	-	HYPH
cord-300872-blycbi4u	260	17	formphenylboronic	formphenylboronic	JJ
cord-300872-blycbi4u	260	18	(	(	-LRB-
cord-300872-blycbi4u	260	19	33	33	CD
cord-300872-blycbi4u	260	20	)	)	-RRB-
cord-300872-blycbi4u	260	21	acid	acid	NN
cord-300872-blycbi4u	260	22	to	to	TO
cord-300872-blycbi4u	260	23	afford	afford	VB
cord-300872-blycbi4u	260	24	synthon	synthon	NNP
cord-300872-blycbi4u	260	25	34	34	CD
cord-300872-blycbi4u	260	26	in	in	IN
cord-300872-blycbi4u	260	27	excellent	excellent	JJ
cord-300872-blycbi4u	260	28	yield	yield	NN
cord-300872-blycbi4u	260	29	.	.	.
cord-300872-blycbi4u	261	1	All	all	DT
cord-300872-blycbi4u	261	2	target	target	NN
cord-300872-blycbi4u	261	3	products	product	NNS
cord-300872-blycbi4u	261	4	(	(	-LRB-
cord-300872-blycbi4u	261	5	35	35	CD
cord-300872-blycbi4u	261	6	)	)	-RRB-
cord-300872-blycbi4u	261	7	were	be	VBD
cord-300872-blycbi4u	261	8	synthesized	synthesize	VBN
cord-300872-blycbi4u	261	9	via	via	IN
cord-300872-blycbi4u	261	10	a	a	DT
cord-300872-blycbi4u	261	11	simple	simple	JJ
cord-300872-blycbi4u	261	12	and	and	CC
cord-300872-blycbi4u	261	13	effective	effective	JJ
cord-300872-blycbi4u	261	14	method	method	NN
cord-300872-blycbi4u	261	15	using	use	VBG
cord-300872-blycbi4u	261	16	a	a	DT
cord-300872-blycbi4u	261	17	one	one	CD
cord-300872-blycbi4u	261	18	-	-	HYPH
cord-300872-blycbi4u	261	19	pot	pot	NN
cord-300872-blycbi4u	261	20	Mannich	Mannich	NNP
cord-300872-blycbi4u	261	21	-	-	HYPH
cord-300872-blycbi4u	261	22	type	type	NN
cord-300872-blycbi4u	261	23	reaction	reaction	NN
cord-300872-blycbi4u	261	24	that	that	WDT
cord-300872-blycbi4u	261	25	involves	involve	VBZ
cord-300872-blycbi4u	261	26	a	a	DT
cord-300872-blycbi4u	261	27	reaction	reaction	NN
cord-300872-blycbi4u	261	28	of	of	IN
cord-300872-blycbi4u	261	29	amines	amine	NNS
cord-300872-blycbi4u	261	30	,	,	,
cord-300872-blycbi4u	261	31	carbonyl	carbonyl	NN
cord-300872-blycbi4u	261	32	compounds	compound	NNS
cord-300872-blycbi4u	261	33	,	,	,
cord-300872-blycbi4u	261	34	and	and	CC
cord-300872-blycbi4u	261	35	dialkylphosphonate	dialkylphosphonate	NNP
cord-300872-blycbi4u	261	36	.	.	.
cord-300872-blycbi4u	262	1	Molecules	molecule	NNS
cord-300872-blycbi4u	262	2	2020	2020	CD
cord-300872-blycbi4u	262	3	,	,	,
cord-300872-blycbi4u	262	4	25	25	CD
cord-300872-blycbi4u	262	5	,	,	,
cord-300872-blycbi4u	262	6	x	x	NN
cord-300872-blycbi4u	262	7	FOR	for	IN
cord-300872-blycbi4u	262	8	PEER	peer	NN
cord-300872-blycbi4u	262	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	262	10	9	9	CD
cord-300872-blycbi4u	262	11	of	of	IN
cord-300872-blycbi4u	262	12	26	26	CD
cord-300872-blycbi4u	263	1	Some	some	DT
cord-300872-blycbi4u	263	2	sulfonates	sulfonate	NNS
cord-300872-blycbi4u	263	3	reported	report	VBN
cord-300872-blycbi4u	263	4	by	by	IN
cord-300872-blycbi4u	263	5	Krishna	Krishna	NNP
cord-300872-blycbi4u	263	6	(	(	-LRB-
cord-300872-blycbi4u	263	7	Scheme	Scheme	NNP
cord-300872-blycbi4u	263	8	4	4	CD
cord-300872-blycbi4u	263	9	)	)	-RRB-
cord-300872-blycbi4u	263	10	were	be	VBD
cord-300872-blycbi4u	263	11	also	also	RB
cord-300872-blycbi4u	263	12	tested	test	VBN
cord-300872-blycbi4u	263	13	in	in	IN
cord-300872-blycbi4u	263	14	vitro	vitro	FW
cord-300872-blycbi4u	263	15	against	against	IN
cord-300872-blycbi4u	263	16	Aspergillus	Aspergillus	NNP
cord-300872-blycbi4u	263	17	niger	niger	NNP
cord-300872-blycbi4u	263	18	and	and	CC
cord-300872-blycbi4u	263	19	Penicillium	Penicillium	NNP
cord-300872-blycbi4u	263	20	spinulosum	spinulosum	NN
cord-300872-blycbi4u	263	21	fungal	fungal	NN
cord-300872-blycbi4u	263	22	strains	strain	NNS
cord-300872-blycbi4u	263	23	by	by	IN
cord-300872-blycbi4u	263	24	the	the	DT
cord-300872-blycbi4u	263	25	poison	poison	NN
cord-300872-blycbi4u	263	26	plate	plate	NN
cord-300872-blycbi4u	263	27	technique	technique	NN
cord-300872-blycbi4u	263	28	;	;	:
cord-300872-blycbi4u	263	29	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	263	30	was	be	VBD
cord-300872-blycbi4u	263	31	used	use	VBN
cord-300872-blycbi4u	263	32	as	as	IN
cord-300872-blycbi4u	263	33	a	a	DT
cord-300872-blycbi4u	263	34	standard	standard	JJ
cord-300872-blycbi4u	263	35	drug	drug	NN
cord-300872-blycbi4u	263	36	for	for	IN
cord-300872-blycbi4u	263	37	antifungal	antifungal	JJ
cord-300872-blycbi4u	263	38	activity	activity	NN
cord-300872-blycbi4u	263	39	.	.	.
cord-300872-blycbi4u	264	1	Two	two	CD
cord-300872-blycbi4u	264	2	compounds	compound	NNS
cord-300872-blycbi4u	264	3	with	with	IN
cord-300872-blycbi4u	264	4	Ar	ar	NN
cord-300872-blycbi4u	264	5	=	=	SYM
cord-300872-blycbi4u	264	6	biphenyl	biphenyl	NN
cord-300872-blycbi4u	264	7	and	and	CC
cord-300872-blycbi4u	264	8	Ar	Ar	NNP
cord-300872-blycbi4u	265	1	=	=	SYM
cord-300872-blycbi4u	265	2	2-nitro-5hydroxybenzene	2-nitro-5hydroxybenzene	CD
cord-300872-blycbi4u	265	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	265	4	the	the	DT
cord-300872-blycbi4u	265	5	most	most	RBS
cord-300872-blycbi4u	265	6	potent	potent	JJ
cord-300872-blycbi4u	265	7	antifungal	antifungal	JJ
cord-300872-blycbi4u	265	8	activity	activity	NN
cord-300872-blycbi4u	265	9	against	against	IN
cord-300872-blycbi4u	265	10	Aspergillus	Aspergillus	NNP
cord-300872-blycbi4u	265	11	niger	niger	NNP
cord-300872-blycbi4u	265	12	,	,	,
cord-300872-blycbi4u	265	13	with	with	IN
cord-300872-blycbi4u	265	14	inhibition	inhibition	NN
cord-300872-blycbi4u	265	15	zones	zone	NNS
cord-300872-blycbi4u	265	16	of	of	IN
cord-300872-blycbi4u	265	17	10	10	CD
cord-300872-blycbi4u	265	18	and	and	CC
cord-300872-blycbi4u	265	19	13	13	CD
cord-300872-blycbi4u	265	20	mm	mm	NNS
cord-300872-blycbi4u	265	21	,	,	,
cord-300872-blycbi4u	265	22	respectively	respectively	RB
cord-300872-blycbi4u	265	23	,	,	,
cord-300872-blycbi4u	265	24	compared	compare	VBN
cord-300872-blycbi4u	265	25	to	to	IN
cord-300872-blycbi4u	265	26	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	265	27	(	(	-LRB-
cord-300872-blycbi4u	265	28	15	15	CD
cord-300872-blycbi4u	265	29	mm	mm	NN
cord-300872-blycbi4u	265	30	)	)	-RRB-
cord-300872-blycbi4u	265	31	;	;	:
cord-300872-blycbi4u	265	32	and	and	CC
cord-300872-blycbi4u	265	33	against	against	IN
cord-300872-blycbi4u	265	34	Penicillium	Penicillium	NNP
cord-300872-blycbi4u	265	35	spinulosum	spinulosum	NNP
cord-300872-blycbi4u	265	36	,	,	,
cord-300872-blycbi4u	265	37	with	with	IN
cord-300872-blycbi4u	265	38	inhibition	inhibition	NN
cord-300872-blycbi4u	265	39	zones	zone	NNS
cord-300872-blycbi4u	265	40	of	of	IN
cord-300872-blycbi4u	265	41	12	12	CD
cord-300872-blycbi4u	265	42	and	and	CC
cord-300872-blycbi4u	265	43	10	10	CD
cord-300872-blycbi4u	265	44	mm	mm	NNS
cord-300872-blycbi4u	265	45	,	,	,
cord-300872-blycbi4u	265	46	respectively	respectively	RB
cord-300872-blycbi4u	265	47	,	,	,
cord-300872-blycbi4u	265	48	compared	compare	VBN
cord-300872-blycbi4u	265	49	to	to	IN
cord-300872-blycbi4u	265	50	fluconazole	fluconazole	NNP
cord-300872-blycbi4u	265	51	(	(	-LRB-
cord-300872-blycbi4u	265	52	12	12	CD
cord-300872-blycbi4u	265	53	mm	mm	NN
cord-300872-blycbi4u	265	54	)	)	-RRB-
cord-300872-blycbi4u	265	55	.	.	.
cord-300872-blycbi4u	266	1	Cancer	cancer	NN
cord-300872-blycbi4u	266	2	is	be	VBZ
cord-300872-blycbi4u	266	3	a	a	DT
cord-300872-blycbi4u	266	4	dreadful	dreadful	JJ
cord-300872-blycbi4u	266	5	disease	disease	NN
cord-300872-blycbi4u	266	6	that	that	WDT
cord-300872-blycbi4u	266	7	has	have	VBZ
cord-300872-blycbi4u	266	8	become	become	VBN
cord-300872-blycbi4u	266	9	a	a	DT
cord-300872-blycbi4u	266	10	global	global	JJ
cord-300872-blycbi4u	266	11	burden	burden	NN
cord-300872-blycbi4u	266	12	,	,	,
cord-300872-blycbi4u	266	13	causing	cause	VBG
cord-300872-blycbi4u	266	14	thousands	thousand	NNS
cord-300872-blycbi4u	266	15	of	of	IN
cord-300872-blycbi4u	266	16	deaths	death	NNS
cord-300872-blycbi4u	266	17	per	per	IN
cord-300872-blycbi4u	266	18	year	year	NN
cord-300872-blycbi4u	266	19	,	,	,
cord-300872-blycbi4u	266	20	despite	despite	IN
cord-300872-blycbi4u	266	21	the	the	DT
cord-300872-blycbi4u	266	22	technological	technological	JJ
cord-300872-blycbi4u	266	23	and	and	CC
cord-300872-blycbi4u	266	24	pharmaceutical	pharmaceutical	JJ
cord-300872-blycbi4u	266	25	improvements	improvement	NNS
cord-300872-blycbi4u	266	26	over	over	IN
cord-300872-blycbi4u	266	27	the	the	DT
cord-300872-blycbi4u	266	28	past	past	JJ
cord-300872-blycbi4u	266	29	several	several	JJ
cord-300872-blycbi4u	266	30	years	year	NNS
cord-300872-blycbi4u	266	31	.	.	.
cord-300872-blycbi4u	267	1	It	-PRON-	PRP
cord-300872-blycbi4u	267	2	has	have	VBZ
cord-300872-blycbi4u	267	3	emerged	emerge	VBN
cord-300872-blycbi4u	267	4	as	as	IN
cord-300872-blycbi4u	267	5	one	one	CD
cord-300872-blycbi4u	267	6	of	of	IN
cord-300872-blycbi4u	267	7	the	the	DT
cord-300872-blycbi4u	267	8	leading	lead	VBG
cord-300872-blycbi4u	267	9	causes	cause	NNS
cord-300872-blycbi4u	267	10	of	of	IN
cord-300872-blycbi4u	267	11	mortality	mortality	NN
cord-300872-blycbi4u	267	12	worldwide	worldwide	RB
cord-300872-blycbi4u	267	13	[	[	-LRB-
cord-300872-blycbi4u	267	14	16	16	CD
cord-300872-blycbi4u	267	15	]	]	-RRB-
cord-300872-blycbi4u	267	16	.	.	.
cord-300872-blycbi4u	268	1	Cancer	cancer	NN
cord-300872-blycbi4u	268	2	treatments	treatment	NNS
cord-300872-blycbi4u	268	3	include	include	VBP
cord-300872-blycbi4u	268	4	surgery	surgery	NN
cord-300872-blycbi4u	268	5	,	,	,
cord-300872-blycbi4u	268	6	radiotherapy	radiotherapy	NN
cord-300872-blycbi4u	268	7	,	,	,
cord-300872-blycbi4u	268	8	and	and	CC
cord-300872-blycbi4u	268	9	anticancer	anticancer	JJ
cord-300872-blycbi4u	268	10	drugs	drug	NNS
cord-300872-blycbi4u	268	11	(	(	-LRB-
cord-300872-blycbi4u	268	12	chemotherapy	chemotherapy	NN
cord-300872-blycbi4u	268	13	)	)	-RRB-
cord-300872-blycbi4u	268	14	,	,	,
cord-300872-blycbi4u	268	15	in	in	IN
cord-300872-blycbi4u	268	16	addition	addition	NN
cord-300872-blycbi4u	268	17	to	to	IN
cord-300872-blycbi4u	268	18	other	other	JJ
cord-300872-blycbi4u	268	19	specialized	specialized	JJ
cord-300872-blycbi4u	268	20	techniques	technique	NNS
cord-300872-blycbi4u	268	21	.	.	.
cord-300872-blycbi4u	269	1	Much	much	JJ
cord-300872-blycbi4u	269	2	scientific	scientific	JJ
cord-300872-blycbi4u	269	3	effort	effort	NN
cord-300872-blycbi4u	269	4	is	be	VBZ
cord-300872-blycbi4u	269	5	being	be	VBG
cord-300872-blycbi4u	269	6	made	make	VBN
cord-300872-blycbi4u	269	7	every	every	DT
cord-300872-blycbi4u	269	8	day	day	NN
cord-300872-blycbi4u	269	9	in	in	IN
cord-300872-blycbi4u	269	10	the	the	DT
cord-300872-blycbi4u	269	11	fight	fight	NN
cord-300872-blycbi4u	269	12	against	against	IN
cord-300872-blycbi4u	269	13	cancer	cancer	NN
cord-300872-blycbi4u	269	14	,	,	,
cord-300872-blycbi4u	269	15	but	but	CC
cord-300872-blycbi4u	269	16	successful	successful	JJ
cord-300872-blycbi4u	269	17	treatment	treatment	NN
cord-300872-blycbi4u	269	18	of	of	IN
cord-300872-blycbi4u	269	19	some	some	DT
cord-300872-blycbi4u	269	20	cancer	cancer	NN
cord-300872-blycbi4u	269	21	types	type	NNS
cord-300872-blycbi4u	269	22	is	be	VBZ
cord-300872-blycbi4u	269	23	still	still	RB
cord-300872-blycbi4u	269	24	a	a	DT
cord-300872-blycbi4u	269	25	challenge	challenge	NN
cord-300872-blycbi4u	269	26	that	that	WDT
cord-300872-blycbi4u	269	27	needs	need	VBZ
cord-300872-blycbi4u	269	28	more	more	JJR
cord-300872-blycbi4u	269	29	work	work	NN
cord-300872-blycbi4u	269	30	[	[	-LRB-
cord-300872-blycbi4u	269	31	17	17	CD
cord-300872-blycbi4u	269	32	]	]	-RRB-
cord-300872-blycbi4u	269	33	.	.	.
cord-300872-blycbi4u	270	1	On	on	IN
cord-300872-blycbi4u	270	2	the	the	DT
cord-300872-blycbi4u	270	3	synthetic	synthetic	JJ
cord-300872-blycbi4u	270	4	front	front	NN
cord-300872-blycbi4u	270	5	in	in	IN
cord-300872-blycbi4u	270	6	the	the	DT
cord-300872-blycbi4u	270	7	fight	fight	NN
cord-300872-blycbi4u	270	8	against	against	IN
cord-300872-blycbi4u	270	9	cancer	cancer	NN
cord-300872-blycbi4u	270	10	,	,	,
cord-300872-blycbi4u	270	11	two	two	CD
cord-300872-blycbi4u	270	12	new	new	JJ
cord-300872-blycbi4u	270	13	series	series	NN
cord-300872-blycbi4u	270	14	of	of	IN
cord-300872-blycbi4u	270	15	derivatives	derivative	NNS
cord-300872-blycbi4u	270	16	have	have	VBP
cord-300872-blycbi4u	270	17	been	be	VBN
cord-300872-blycbi4u	270	18	prepared	prepare	VBN
cord-300872-blycbi4u	270	19	where	where	WRB
cord-300872-blycbi4u	270	20	the	the	DT
cord-300872-blycbi4u	270	21	bioactive	bioactive	JJ
cord-300872-blycbi4u	270	22	quinolone	quinolone	NNP
cord-300872-blycbi4u	270	23	motif	motif	NN
cord-300872-blycbi4u	270	24	is	be	VBZ
cord-300872-blycbi4u	270	25	incorporated	incorporate	VBN
cord-300872-blycbi4u	270	26	,	,	,
cord-300872-blycbi4u	270	27	as	as	IN
cord-300872-blycbi4u	270	28	shown	show	VBN
cord-300872-blycbi4u	270	29	in	in	IN
cord-300872-blycbi4u	270	30	Scheme	Scheme	NNP
cord-300872-blycbi4u	270	31	10	10	CD
cord-300872-blycbi4u	270	32	[	[	-LRB-
cord-300872-blycbi4u	270	33	18	18	CD
cord-300872-blycbi4u	270	34	]	]	-RRB-
cord-300872-blycbi4u	270	35	.	.	.
cord-300872-blycbi4u	271	1	6-Bromo-8-methoxyquinoline	6-bromo-8-methoxyquinoline	CD
cord-300872-blycbi4u	272	1	(	(	-LRB-
cord-300872-blycbi4u	272	2	1	1	LS
cord-300872-blycbi4u	272	3	)	)	-RRB-
cord-300872-blycbi4u	272	4	was	be	VBD
cord-300872-blycbi4u	272	5	prepared	prepare	VBN
cord-300872-blycbi4u	272	6	according	accord	VBG
cord-300872-blycbi4u	272	7	to	to	IN
cord-300872-blycbi4u	272	8	a	a	DT
cord-300872-blycbi4u	272	9	published	publish	VBN
cord-300872-blycbi4u	272	10	procedure	procedure	NN
cord-300872-blycbi4u	272	11	[	[	-LRB-
cord-300872-blycbi4u	272	12	19	19	CD
cord-300872-blycbi4u	272	13	]	]	-RRB-
cord-300872-blycbi4u	272	14	.	.	.
cord-300872-blycbi4u	273	1	Afterwards	afterwards	RB
cord-300872-blycbi4u	273	2	,	,	,
cord-300872-blycbi4u	273	3	compound	compound	NN
cord-300872-blycbi4u	273	4	32	32	CD
cord-300872-blycbi4u	273	5	was	be	VBD
cord-300872-blycbi4u	273	6	subjected	subject	VBN
cord-300872-blycbi4u	273	7	to	to	IN
cord-300872-blycbi4u	273	8	a	a	DT
cord-300872-blycbi4u	273	9	Suzuki	Suzuki	NNP
cord-300872-blycbi4u	273	10	crosscoupling	crosscoupling	NN
cord-300872-blycbi4u	273	11	reaction	reaction	NN
cord-300872-blycbi4u	273	12	with	with	IN
cord-300872-blycbi4u	273	13	p	p	NN
cord-300872-blycbi4u	273	14	-	-	HYPH
cord-300872-blycbi4u	273	15	formphenylboronic	formphenylboronic	JJ
cord-300872-blycbi4u	273	16	(	(	-LRB-
cord-300872-blycbi4u	273	17	33	33	CD
cord-300872-blycbi4u	273	18	)	)	-RRB-
cord-300872-blycbi4u	273	19	acid	acid	NN
cord-300872-blycbi4u	273	20	to	to	TO
cord-300872-blycbi4u	273	21	afford	afford	VB
cord-300872-blycbi4u	273	22	synthon	synthon	NNP
cord-300872-blycbi4u	273	23	34	34	CD
cord-300872-blycbi4u	273	24	in	in	IN
cord-300872-blycbi4u	273	25	excellent	excellent	JJ
cord-300872-blycbi4u	273	26	yield	yield	NN
cord-300872-blycbi4u	273	27	.	.	.
cord-300872-blycbi4u	274	1	All	all	DT
cord-300872-blycbi4u	274	2	target	target	NN
cord-300872-blycbi4u	274	3	products	product	NNS
cord-300872-blycbi4u	274	4	(	(	-LRB-
cord-300872-blycbi4u	274	5	35	35	CD
cord-300872-blycbi4u	274	6	)	)	-RRB-
cord-300872-blycbi4u	274	7	were	be	VBD
cord-300872-blycbi4u	274	8	synthesized	synthesize	VBN
cord-300872-blycbi4u	274	9	via	via	IN
cord-300872-blycbi4u	274	10	a	a	DT
cord-300872-blycbi4u	274	11	simple	simple	JJ
cord-300872-blycbi4u	274	12	and	and	CC
cord-300872-blycbi4u	274	13	effective	effective	JJ
cord-300872-blycbi4u	274	14	method	method	NN
cord-300872-blycbi4u	274	15	using	use	VBG
cord-300872-blycbi4u	274	16	a	a	DT
cord-300872-blycbi4u	274	17	one	one	CD
cord-300872-blycbi4u	274	18	-	-	HYPH
cord-300872-blycbi4u	274	19	pot	pot	NN
cord-300872-blycbi4u	274	20	Mannichtype	Mannichtype	NNP
cord-300872-blycbi4u	274	21	reaction	reaction	NN
cord-300872-blycbi4u	274	22	that	that	WDT
cord-300872-blycbi4u	274	23	involves	involve	VBZ
cord-300872-blycbi4u	274	24	a	a	DT
cord-300872-blycbi4u	274	25	reaction	reaction	NN
cord-300872-blycbi4u	274	26	of	of	IN
cord-300872-blycbi4u	274	27	amines	amine	NNS
cord-300872-blycbi4u	274	28	,	,	,
cord-300872-blycbi4u	274	29	carbonyl	carbonyl	NN
cord-300872-blycbi4u	274	30	compounds	compound	NNS
cord-300872-blycbi4u	274	31	,	,	,
cord-300872-blycbi4u	274	32	and	and	CC
cord-300872-blycbi4u	274	33	dialkylphosphonate	dialkylphosphonate	NNP
cord-300872-blycbi4u	274	34	.	.	.
cord-300872-blycbi4u	275	1	The	the	DT
cord-300872-blycbi4u	275	2	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	275	3	of	of	IN
cord-300872-blycbi4u	275	4	these	these	DT
cord-300872-blycbi4u	275	5	prepared	prepared	JJ
cord-300872-blycbi4u	275	6	compounds	compound	NNS
cord-300872-blycbi4u	275	7	against	against	IN
cord-300872-blycbi4u	275	8	esophageal	esophageal	JJ
cord-300872-blycbi4u	275	9	(	(	-LRB-
cord-300872-blycbi4u	275	10	Eca109	Eca109	NNS
cord-300872-blycbi4u	275	11	)	)	-RRB-
cord-300872-blycbi4u	275	12	and	and	CC
cord-300872-blycbi4u	275	13	hepatocellular	hepatocellular	JJ
cord-300872-blycbi4u	275	14	(	(	-LRB-
cord-300872-blycbi4u	275	15	Huh7	huh7	NN
cord-300872-blycbi4u	275	16	)	)	-RRB-
cord-300872-blycbi4u	275	17	cancer	cancer	NN
cord-300872-blycbi4u	275	18	cell	cell	NN
cord-300872-blycbi4u	275	19	lines	line	NNS
cord-300872-blycbi4u	275	20	was	be	VBD
cord-300872-blycbi4u	275	21	evaluated	evaluate	VBN
cord-300872-blycbi4u	275	22	using	use	VBG
cord-300872-blycbi4u	275	23	sunitinib	sunitinib	JJ
cord-300872-blycbi4u	275	24	as	as	IN
cord-300872-blycbi4u	275	25	a	a	DT
cord-300872-blycbi4u	275	26	positive	positive	JJ
cord-300872-blycbi4u	275	27	control	control	NN
cord-300872-blycbi4u	275	28	.	.	.
cord-300872-blycbi4u	276	1	The	the	DT
cord-300872-blycbi4u	276	2	results	result	NNS
cord-300872-blycbi4u	276	3	showed	show	VBD
cord-300872-blycbi4u	276	4	that	that	IN
cord-300872-blycbi4u	276	5	most	most	JJS
cord-300872-blycbi4u	276	6	of	of	IN
cord-300872-blycbi4u	276	7	these	these	DT
cord-300872-blycbi4u	276	8	compounds	compound	NNS
cord-300872-blycbi4u	276	9	exhibit	exhibit	VBP
cord-300872-blycbi4u	276	10	moderate	moderate	JJ
cord-300872-blycbi4u	276	11	to	to	IN
cord-300872-blycbi4u	276	12	high	high	JJ
cord-300872-blycbi4u	276	13	activity	activity	NN
cord-300872-blycbi4u	276	14	,	,	,
cord-300872-blycbi4u	276	15	with	with	IN
cord-300872-blycbi4u	276	16	IC50	ic50	JJ
cord-300872-blycbi4u	276	17	values	value	NNS
cord-300872-blycbi4u	276	18	ranging	range	VBG
cord-300872-blycbi4u	276	19	from	from	IN
cord-300872-blycbi4u	276	20	2.26	2.26	CD
cord-300872-blycbi4u	276	21	to	to	IN
cord-300872-blycbi4u	276	22	7.46	7.46	CD
cord-300872-blycbi4u	276	23	µmol	µmol	NNP
cord-300872-blycbi4u	276	24	/	/	SYM
cord-300872-blycbi4u	276	25	L	l	NN
cord-300872-blycbi4u	276	26	for	for	IN
cord-300872-blycbi4u	276	27	the	the	DT
cord-300872-blycbi4u	276	28	two	two	CD
cord-300872-blycbi4u	276	29	most	most	RBS
cord-300872-blycbi4u	276	30	promising	promising	JJ
cord-300872-blycbi4u	276	31	derivatives	derivative	NNS
cord-300872-blycbi4u	276	32	containing	contain	VBG
cord-300872-blycbi4u	276	33	2-methylphenyl	2-methylphenyl	CD
cord-300872-blycbi4u	276	34	and	and	CC
cord-300872-blycbi4u	276	35	4-methylphenyl	4-methylphenyl	CD
cord-300872-blycbi4u	276	36	groups	group	NNS
cord-300872-blycbi4u	276	37	for	for	IN
cord-300872-blycbi4u	276	38	R	r	NN
cord-300872-blycbi4u	276	39	2	2	CD
cord-300872-blycbi4u	276	40	and	and	CC
cord-300872-blycbi4u	276	41	iso	iso	NN
cord-300872-blycbi4u	276	42	-	-	HYPH
cord-300872-blycbi4u	276	43	propyl	propyl	JJ
cord-300872-blycbi4u	276	44	for	for	IN
cord-300872-blycbi4u	276	45	R	r	NN
cord-300872-blycbi4u	276	46	1	1	CD
cord-300872-blycbi4u	276	47	;	;	:
cord-300872-blycbi4u	276	48	some	some	DT
cord-300872-blycbi4u	276	49	of	of	IN
cord-300872-blycbi4u	276	50	these	these	DT
cord-300872-blycbi4u	276	51	compounds	compound	NNS
cord-300872-blycbi4u	276	52	exhibited	exhibit	VBD
cord-300872-blycbi4u	276	53	inhibition	inhibition	NN
cord-300872-blycbi4u	276	54	activities	activity	NNS
cord-300872-blycbi4u	276	55	comparable	comparable	JJ
cord-300872-blycbi4u	276	56	to	to	IN
cord-300872-blycbi4u	276	57	those	those	DT
cord-300872-blycbi4u	276	58	of	of	IN
cord-300872-blycbi4u	276	59	sunitinib	sunitinib	NN
cord-300872-blycbi4u	276	60	,	,	,
cord-300872-blycbi4u	276	61	which	which	WDT
cord-300872-blycbi4u	276	62	showed	show	VBD
cord-300872-blycbi4u	276	63	IC50	ic50	JJ
cord-300872-blycbi4u	276	64	values	value	NNS
cord-300872-blycbi4u	276	65	of	of	IN
cord-300872-blycbi4u	276	66	16.54	16.54	CD
cord-300872-blycbi4u	276	67	and	and	CC
cord-300872-blycbi4u	276	68	5.27	5.27	CD
cord-300872-blycbi4u	276	69	µmol	µmol	NNP
cord-300872-blycbi4u	276	70	/	/	SYM
cord-300872-blycbi4u	276	71	L	L	NNP
cord-300872-blycbi4u	276	72	towards	towards	IN
cord-300872-blycbi4u	276	73	Eca109	eca109	NN
cord-300872-blycbi4u	276	74	and	and	CC
cord-300872-blycbi4u	276	75	Huh7	Huh7	NNP
cord-300872-blycbi4u	276	76	,	,	,
cord-300872-blycbi4u	276	77	respectively	respectively	RB
cord-300872-blycbi4u	276	78	.	.	.
cord-300872-blycbi4u	277	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	277	2	,	,	,
cord-300872-blycbi4u	277	3	the	the	DT
cord-300872-blycbi4u	277	4	results	result	NNS
cord-300872-blycbi4u	277	5	indicated	indicate	VBD
cord-300872-blycbi4u	277	6	that	that	IN
cord-300872-blycbi4u	277	7	ethyl	ethyl	NN
cord-300872-blycbi4u	277	8	and	and	CC
cord-300872-blycbi4u	277	9	isopropyl	isopropyl	NN
cord-300872-blycbi4u	277	10	substituents	substituent	NNS
cord-300872-blycbi4u	277	11	of	of	IN
cord-300872-blycbi4u	277	12	phosphonate	phosphonate	NNP
cord-300872-blycbi4u	277	13	have	have	VBP
cord-300872-blycbi4u	277	14	no	no	DT
cord-300872-blycbi4u	277	15	major	major	JJ
cord-300872-blycbi4u	277	16	effects	effect	NNS
cord-300872-blycbi4u	277	17	on	on	IN
cord-300872-blycbi4u	277	18	the	the	DT
cord-300872-blycbi4u	277	19	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	277	20	activity	activity	NN
cord-300872-blycbi4u	277	21	,	,	,
cord-300872-blycbi4u	277	22	while	while	IN
cord-300872-blycbi4u	277	23	substituents	substituent	NNS
cord-300872-blycbi4u	277	24	on	on	IN
cord-300872-blycbi4u	277	25	the	the	DT
cord-300872-blycbi4u	277	26	phenyl	phenyl	NN
cord-300872-blycbi4u	277	27	ring	ring	NN
cord-300872-blycbi4u	277	28	showed	show	VBD
cord-300872-blycbi4u	277	29	significant	significant	JJ
cord-300872-blycbi4u	277	30	influence	influence	NN
cord-300872-blycbi4u	277	31	on	on	IN
cord-300872-blycbi4u	277	32	the	the	DT
cord-300872-blycbi4u	277	33	bioactivity	bioactivity	NN
cord-300872-blycbi4u	277	34	.	.	.
cord-300872-blycbi4u	278	1	The	the	DT
cord-300872-blycbi4u	278	2	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	278	3	of	of	IN
cord-300872-blycbi4u	278	4	these	these	DT
cord-300872-blycbi4u	278	5	prepared	prepared	JJ
cord-300872-blycbi4u	278	6	compounds	compound	NNS
cord-300872-blycbi4u	278	7	against	against	IN
cord-300872-blycbi4u	278	8	esophageal	esophageal	JJ
cord-300872-blycbi4u	278	9	(	(	-LRB-
cord-300872-blycbi4u	278	10	Eca109	Eca109	NNS
cord-300872-blycbi4u	278	11	)	)	-RRB-
cord-300872-blycbi4u	278	12	and	and	CC
cord-300872-blycbi4u	278	13	hepatocellular	hepatocellular	JJ
cord-300872-blycbi4u	278	14	(	(	-LRB-
cord-300872-blycbi4u	278	15	Huh7	huh7	NN
cord-300872-blycbi4u	278	16	)	)	-RRB-
cord-300872-blycbi4u	278	17	cancer	cancer	NN
cord-300872-blycbi4u	278	18	cell	cell	NN
cord-300872-blycbi4u	278	19	lines	line	NNS
cord-300872-blycbi4u	278	20	was	be	VBD
cord-300872-blycbi4u	278	21	evaluated	evaluate	VBN
cord-300872-blycbi4u	278	22	using	use	VBG
cord-300872-blycbi4u	278	23	sunitinib	sunitinib	JJ
cord-300872-blycbi4u	278	24	as	as	IN
cord-300872-blycbi4u	278	25	a	a	DT
cord-300872-blycbi4u	278	26	positive	positive	JJ
cord-300872-blycbi4u	278	27	control	control	NN
cord-300872-blycbi4u	278	28	.	.	.
cord-300872-blycbi4u	279	1	The	the	DT
cord-300872-blycbi4u	279	2	results	result	NNS
cord-300872-blycbi4u	279	3	showed	show	VBD
cord-300872-blycbi4u	279	4	that	that	IN
cord-300872-blycbi4u	279	5	most	most	JJS
cord-300872-blycbi4u	279	6	of	of	IN
cord-300872-blycbi4u	279	7	these	these	DT
cord-300872-blycbi4u	279	8	compounds	compound	NNS
cord-300872-blycbi4u	279	9	exhibit	exhibit	VBP
cord-300872-blycbi4u	279	10	moderate	moderate	JJ
cord-300872-blycbi4u	279	11	to	to	IN
cord-300872-blycbi4u	279	12	high	high	JJ
cord-300872-blycbi4u	279	13	activity	activity	NN
cord-300872-blycbi4u	279	14	,	,	,
cord-300872-blycbi4u	279	15	with	with	IN
cord-300872-blycbi4u	279	16	IC	IC	NNP
cord-300872-blycbi4u	279	17	50	50	CD
cord-300872-blycbi4u	279	18	values	value	NNS
cord-300872-blycbi4u	279	19	ranging	range	VBG
cord-300872-blycbi4u	279	20	from	from	IN
cord-300872-blycbi4u	279	21	2.26	2.26	CD
cord-300872-blycbi4u	279	22	to	to	IN
cord-300872-blycbi4u	279	23	7.46	7.46	CD
cord-300872-blycbi4u	279	24	µmol	µmol	NNP
cord-300872-blycbi4u	279	25	/	/	SYM
cord-300872-blycbi4u	279	26	L	l	NN
cord-300872-blycbi4u	279	27	for	for	IN
cord-300872-blycbi4u	279	28	the	the	DT
cord-300872-blycbi4u	279	29	two	two	CD
cord-300872-blycbi4u	279	30	most	most	RBS
cord-300872-blycbi4u	279	31	promising	promising	JJ
cord-300872-blycbi4u	279	32	derivatives	derivative	NNS
cord-300872-blycbi4u	279	33	containing	contain	VBG
cord-300872-blycbi4u	279	34	2-methylphenyl	2-methylphenyl	CD
cord-300872-blycbi4u	279	35	and	and	CC
cord-300872-blycbi4u	279	36	4-methylphenyl	4-methylphenyl	CD
cord-300872-blycbi4u	279	37	groups	group	NNS
cord-300872-blycbi4u	279	38	for	for	IN
cord-300872-blycbi4u	279	39	R	r	NN
cord-300872-blycbi4u	279	40	2	2	CD
cord-300872-blycbi4u	279	41	and	and	CC
cord-300872-blycbi4u	279	42	iso	iso	NN
cord-300872-blycbi4u	279	43	-	-	HYPH
cord-300872-blycbi4u	279	44	propyl	propyl	JJ
cord-300872-blycbi4u	279	45	for	for	IN
cord-300872-blycbi4u	279	46	R	r	NN
cord-300872-blycbi4u	279	47	1	1	CD
cord-300872-blycbi4u	279	48	;	;	:
cord-300872-blycbi4u	279	49	some	some	DT
cord-300872-blycbi4u	279	50	of	of	IN
cord-300872-blycbi4u	279	51	these	these	DT
cord-300872-blycbi4u	279	52	compounds	compound	NNS
cord-300872-blycbi4u	279	53	exhibited	exhibit	VBD
cord-300872-blycbi4u	279	54	inhibition	inhibition	NN
cord-300872-blycbi4u	279	55	activities	activity	NNS
cord-300872-blycbi4u	279	56	comparable	comparable	JJ
cord-300872-blycbi4u	279	57	to	to	IN
cord-300872-blycbi4u	279	58	those	those	DT
cord-300872-blycbi4u	279	59	of	of	IN
cord-300872-blycbi4u	279	60	sunitinib	sunitinib	NN
cord-300872-blycbi4u	279	61	,	,	,
cord-300872-blycbi4u	279	62	which	which	WDT
cord-300872-blycbi4u	279	63	showed	show	VBD
cord-300872-blycbi4u	279	64	IC	IC	NNP
cord-300872-blycbi4u	279	65	50	50	CD
cord-300872-blycbi4u	279	66	values	value	NNS
cord-300872-blycbi4u	279	67	of	of	IN
cord-300872-blycbi4u	279	68	16.54	16.54	CD
cord-300872-blycbi4u	279	69	and	and	CC
cord-300872-blycbi4u	279	70	5.27	5.27	CD
cord-300872-blycbi4u	279	71	µmol	µmol	NNP
cord-300872-blycbi4u	279	72	/	/	SYM
cord-300872-blycbi4u	279	73	L	L	NNP
cord-300872-blycbi4u	279	74	towards	towards	IN
cord-300872-blycbi4u	279	75	Eca109	eca109	NN
cord-300872-blycbi4u	279	76	and	and	CC
cord-300872-blycbi4u	279	77	Huh7	Huh7	NNP
cord-300872-blycbi4u	279	78	,	,	,
cord-300872-blycbi4u	279	79	respectively	respectively	RB
cord-300872-blycbi4u	279	80	.	.	.
cord-300872-blycbi4u	280	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	280	2	,	,	,
cord-300872-blycbi4u	280	3	the	the	DT
cord-300872-blycbi4u	280	4	results	result	NNS
cord-300872-blycbi4u	280	5	indicated	indicate	VBD
cord-300872-blycbi4u	280	6	that	that	IN
cord-300872-blycbi4u	280	7	ethyl	ethyl	NN
cord-300872-blycbi4u	280	8	and	and	CC
cord-300872-blycbi4u	280	9	isopropyl	isopropyl	NN
cord-300872-blycbi4u	280	10	substituents	substituent	NNS
cord-300872-blycbi4u	280	11	of	of	IN
cord-300872-blycbi4u	280	12	phosphonate	phosphonate	NNP
cord-300872-blycbi4u	280	13	have	have	VBP
cord-300872-blycbi4u	280	14	no	no	DT
cord-300872-blycbi4u	280	15	major	major	JJ
cord-300872-blycbi4u	280	16	effects	effect	NNS
cord-300872-blycbi4u	280	17	on	on	IN
cord-300872-blycbi4u	280	18	the	the	DT
cord-300872-blycbi4u	280	19	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	280	20	activity	activity	NN
cord-300872-blycbi4u	280	21	,	,	,
cord-300872-blycbi4u	280	22	while	while	IN
cord-300872-blycbi4u	280	23	substituents	substituent	NNS
cord-300872-blycbi4u	280	24	on	on	IN
cord-300872-blycbi4u	280	25	the	the	DT
cord-300872-blycbi4u	280	26	phenyl	phenyl	NN
cord-300872-blycbi4u	280	27	ring	ring	NN
cord-300872-blycbi4u	280	28	showed	show	VBD
cord-300872-blycbi4u	280	29	significant	significant	JJ
cord-300872-blycbi4u	280	30	influence	influence	NN
cord-300872-blycbi4u	280	31	on	on	IN
cord-300872-blycbi4u	280	32	the	the	DT
cord-300872-blycbi4u	280	33	bioactivity	bioactivity	NN
cord-300872-blycbi4u	280	34	.	.	.
cord-300872-blycbi4u	281	1	Faydy	Faydy	NNP
cord-300872-blycbi4u	281	2	and	and	CC
cord-300872-blycbi4u	281	3	coworkers	coworker	NNS
cord-300872-blycbi4u	281	4	described	describe	VBD
cord-300872-blycbi4u	281	5	the	the	DT
cord-300872-blycbi4u	281	6	synthesis	synthesis	NN
cord-300872-blycbi4u	281	7	of	of	IN
cord-300872-blycbi4u	281	8	new	new	JJ
cord-300872-blycbi4u	281	9	derivatives	derivative	NNS
cord-300872-blycbi4u	281	10	of	of	IN
cord-300872-blycbi4u	281	11	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	281	12	(	(	-LRB-
cord-300872-blycbi4u	281	13	36	36	CD
cord-300872-blycbi4u	281	14	-	-	SYM
cord-300872-blycbi4u	281	15	38	38	CD
cord-300872-blycbi4u	281	16	)	)	-RRB-
cord-300872-blycbi4u	281	17	(	(	-LRB-
cord-300872-blycbi4u	281	18	Figure	figure	NN
cord-300872-blycbi4u	281	19	2	2	CD
cord-300872-blycbi4u	281	20	)	)	-RRB-
cord-300872-blycbi4u	281	21	in	in	IN
cord-300872-blycbi4u	281	22	a	a	DT
cord-300872-blycbi4u	281	23	multistep	multistep	JJ
cord-300872-blycbi4u	281	24	approach	approach	NN
cord-300872-blycbi4u	281	25	[	[	-LRB-
cord-300872-blycbi4u	281	26	20	20	CD
cord-300872-blycbi4u	281	27	]	]	-RRB-
cord-300872-blycbi4u	281	28	according	accord	VBG
cord-300872-blycbi4u	281	29	to	to	IN
cord-300872-blycbi4u	281	30	published	publish	VBN
cord-300872-blycbi4u	281	31	procedures	procedure	NNS
cord-300872-blycbi4u	281	32	[	[	-LRB-
cord-300872-blycbi4u	281	33	21	21	CD
cord-300872-blycbi4u	281	34	]	]	-RRB-
cord-300872-blycbi4u	281	35	[	[	-LRB-
cord-300872-blycbi4u	281	36	22	22	CD
cord-300872-blycbi4u	281	37	]	]	-RRB-
cord-300872-blycbi4u	281	38	[	[	-LRB-
cord-300872-blycbi4u	281	39	23	23	CD
cord-300872-blycbi4u	281	40	]	]	-RRB-
cord-300872-blycbi4u	281	41	.	.	.
cord-300872-blycbi4u	282	1	The	the	DT
cord-300872-blycbi4u	282	2	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	282	3	activity	activity	NN
cord-300872-blycbi4u	282	4	of	of	IN
cord-300872-blycbi4u	282	5	prepared	prepared	JJ
cord-300872-blycbi4u	282	6	products	product	NNS
cord-300872-blycbi4u	282	7	,	,	,
cord-300872-blycbi4u	282	8	along	along	IN
cord-300872-blycbi4u	282	9	with	with	IN
cord-300872-blycbi4u	282	10	L	l	NN
cord-300872-blycbi4u	282	11	-	-	HYPH
cord-300872-blycbi4u	282	12	ascorbic	ascorbic	NN
cord-300872-blycbi4u	282	13	acid	acid	NN
cord-300872-blycbi4u	282	14	,	,	,
cord-300872-blycbi4u	282	15	was	be	VBD
cord-300872-blycbi4u	282	16	evaluated	evaluate	VBN
cord-300872-blycbi4u	282	17	by	by	IN
cord-300872-blycbi4u	282	18	means	mean	NNS
cord-300872-blycbi4u	282	19	of	of	IN
cord-300872-blycbi4u	282	20	the	the	DT
cord-300872-blycbi4u	282	21	free	free	JJ
cord-300872-blycbi4u	282	22	radical	radical	JJ
cord-300872-blycbi4u	282	23	scavenging	scavenging	NN
cord-300872-blycbi4u	282	24	method	method	NN
cord-300872-blycbi4u	282	25	using	use	VBG
cord-300872-blycbi4u	282	26	the	the	DT
cord-300872-blycbi4u	282	27	2,2-diphenyl-1-picryhydrazyl	2,2-diphenyl-1-picryhydrazyl	CD
cord-300872-blycbi4u	282	28	(	(	-LRB-
cord-300872-blycbi4u	282	29	DPPH	DPPH	NNP
cord-300872-blycbi4u	282	30	)	)	-RRB-
cord-300872-blycbi4u	282	31	assay	assay	NN
cord-300872-blycbi4u	282	32	.	.	.
cord-300872-blycbi4u	283	1	The	the	DT
cord-300872-blycbi4u	283	2	results	result	NNS
cord-300872-blycbi4u	283	3	revealed	reveal	VBD
cord-300872-blycbi4u	283	4	that	that	IN
cord-300872-blycbi4u	283	5	all	all	DT
cord-300872-blycbi4u	283	6	products	product	NNS
cord-300872-blycbi4u	283	7	showed	show	VBD
cord-300872-blycbi4u	283	8	low	low	JJ
cord-300872-blycbi4u	283	9	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	283	10	activity	activity	NN
cord-300872-blycbi4u	283	11	,	,	,
cord-300872-blycbi4u	283	12	with	with	IN
cord-300872-blycbi4u	283	13	IC	IC	NNP
cord-300872-blycbi4u	283	14	50	50	CD
cord-300872-blycbi4u	283	15	values	value	NNS
cord-300872-blycbi4u	283	16	of	of	IN
cord-300872-blycbi4u	283	17	0.8	0.8	CD
cord-300872-blycbi4u	283	18	-	-	HYPH
cord-300872-blycbi4u	283	19	2.49	2.49	CD
cord-300872-blycbi4u	283	20	mg	mg	NNP
cord-300872-blycbi4u	283	21	/	/	SYM
cord-300872-blycbi4u	283	22	mL	mL	NNP
cord-300872-blycbi4u	283	23	,	,	,
cord-300872-blycbi4u	283	24	whereas	whereas	IN
cord-300872-blycbi4u	283	25	the	the	DT
cord-300872-blycbi4u	283	26	IC	IC	NNP
cord-300872-blycbi4u	283	27	50	50	CD
cord-300872-blycbi4u	283	28	value	value	NN
cord-300872-blycbi4u	283	29	of	of	IN
cord-300872-blycbi4u	283	30	1-ascorbic	1-ascorbic	CD
cord-300872-blycbi4u	283	31	acid	acid	NN
cord-300872-blycbi4u	283	32	was	be	VBD
cord-300872-blycbi4u	283	33	0.1	0.1	CD
cord-300872-blycbi4u	283	34	mg	mg	NNP
cord-300872-blycbi4u	283	35	/	/	SYM
cord-300872-blycbi4u	283	36	mL.	ml.	NN
cord-300872-blycbi4u	284	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	284	2	,	,	,
cord-300872-blycbi4u	284	3	the	the	DT
cord-300872-blycbi4u	284	4	results	result	NNS
cord-300872-blycbi4u	284	5	showed	show	VBD
cord-300872-blycbi4u	284	6	that	that	IN
cord-300872-blycbi4u	284	7	as	as	IN
cord-300872-blycbi4u	284	8	the	the	DT
cord-300872-blycbi4u	284	9	number	number	NN
cord-300872-blycbi4u	284	10	of	of	IN
cord-300872-blycbi4u	284	11	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	284	12	groups	group	NNS
cord-300872-blycbi4u	284	13	increases	increase	VBZ
cord-300872-blycbi4u	284	14	,	,	,
cord-300872-blycbi4u	284	15	the	the	DT
cord-300872-blycbi4u	284	16	inhibition	inhibition	NN
cord-300872-blycbi4u	284	17	activity	activity	NN
cord-300872-blycbi4u	284	18	increases	increase	VBZ
cord-300872-blycbi4u	284	19	too	too	RB
cord-300872-blycbi4u	284	20	.	.	.
cord-300872-blycbi4u	285	1	Molecules	molecule	NNS
cord-300872-blycbi4u	285	2	2020	2020	CD
cord-300872-blycbi4u	285	3	,	,	,
cord-300872-blycbi4u	285	4	25	25	CD
cord-300872-blycbi4u	285	5	,	,	,
cord-300872-blycbi4u	285	6	x	x	NN
cord-300872-blycbi4u	285	7	FOR	for	IN
cord-300872-blycbi4u	285	8	PEER	PEER	NNP
cord-300872-blycbi4u	285	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	285	10	10	10	CD
cord-300872-blycbi4u	285	11	of	of	IN
cord-300872-blycbi4u	285	12	26	26	CD
cord-300872-blycbi4u	285	13	Faydy	Faydy	NNP
cord-300872-blycbi4u	285	14	and	and	CC
cord-300872-blycbi4u	285	15	coworkers	coworker	NNS
cord-300872-blycbi4u	285	16	described	describe	VBD
cord-300872-blycbi4u	285	17	the	the	DT
cord-300872-blycbi4u	285	18	synthesis	synthesis	NN
cord-300872-blycbi4u	285	19	of	of	IN
cord-300872-blycbi4u	285	20	new	new	JJ
cord-300872-blycbi4u	285	21	derivatives	derivative	NNS
cord-300872-blycbi4u	285	22	of	of	IN
cord-300872-blycbi4u	285	23	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	285	24	(	(	-LRB-
cord-300872-blycbi4u	285	25	36	36	CD
cord-300872-blycbi4u	285	26	-	-	SYM
cord-300872-blycbi4u	285	27	38	38	CD
cord-300872-blycbi4u	285	28	)	)	-RRB-
cord-300872-blycbi4u	285	29	(	(	-LRB-
cord-300872-blycbi4u	285	30	Figure	figure	NN
cord-300872-blycbi4u	285	31	2	2	CD
cord-300872-blycbi4u	285	32	)	)	-RRB-
cord-300872-blycbi4u	285	33	in	in	IN
cord-300872-blycbi4u	285	34	a	a	DT
cord-300872-blycbi4u	285	35	multistep	multistep	JJ
cord-300872-blycbi4u	285	36	approach	approach	NN
cord-300872-blycbi4u	285	37	[	[	-LRB-
cord-300872-blycbi4u	285	38	20	20	CD
cord-300872-blycbi4u	285	39	]	]	-RRB-
cord-300872-blycbi4u	285	40	according	accord	VBG
cord-300872-blycbi4u	285	41	to	to	IN
cord-300872-blycbi4u	285	42	published	publish	VBN
cord-300872-blycbi4u	285	43	procedures	procedure	NNS
cord-300872-blycbi4u	285	44	[	[	-LRB-
cord-300872-blycbi4u	285	45	21	21	CD
cord-300872-blycbi4u	285	46	]	]	-RRB-
cord-300872-blycbi4u	285	47	[	[	-LRB-
cord-300872-blycbi4u	285	48	22	22	CD
cord-300872-blycbi4u	285	49	]	]	-RRB-
cord-300872-blycbi4u	285	50	[	[	-LRB-
cord-300872-blycbi4u	285	51	23	23	CD
cord-300872-blycbi4u	285	52	]	]	-RRB-
cord-300872-blycbi4u	285	53	.	.	.
cord-300872-blycbi4u	286	1	The	the	DT
cord-300872-blycbi4u	286	2	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	286	3	activity	activity	NN
cord-300872-blycbi4u	286	4	of	of	IN
cord-300872-blycbi4u	286	5	prepared	prepared	JJ
cord-300872-blycbi4u	286	6	products	product	NNS
cord-300872-blycbi4u	286	7	,	,	,
cord-300872-blycbi4u	286	8	along	along	IN
cord-300872-blycbi4u	286	9	with	with	IN
cord-300872-blycbi4u	286	10	L	l	NN
cord-300872-blycbi4u	286	11	-	-	HYPH
cord-300872-blycbi4u	286	12	ascorbic	ascorbic	NN
cord-300872-blycbi4u	286	13	acid	acid	NN
cord-300872-blycbi4u	286	14	,	,	,
cord-300872-blycbi4u	286	15	was	be	VBD
cord-300872-blycbi4u	286	16	evaluated	evaluate	VBN
cord-300872-blycbi4u	286	17	by	by	IN
cord-300872-blycbi4u	286	18	means	mean	NNS
cord-300872-blycbi4u	286	19	of	of	IN
cord-300872-blycbi4u	286	20	the	the	DT
cord-300872-blycbi4u	286	21	free	free	JJ
cord-300872-blycbi4u	286	22	radical	radical	JJ
cord-300872-blycbi4u	286	23	scavenging	scavenging	NN
cord-300872-blycbi4u	286	24	method	method	NN
cord-300872-blycbi4u	286	25	using	use	VBG
cord-300872-blycbi4u	286	26	the	the	DT
cord-300872-blycbi4u	286	27	2,2-diphenyl-1-picryhydrazyl	2,2-diphenyl-1-picryhydrazyl	CD
cord-300872-blycbi4u	286	28	(	(	-LRB-
cord-300872-blycbi4u	286	29	DPPH	DPPH	NNP
cord-300872-blycbi4u	286	30	)	)	-RRB-
cord-300872-blycbi4u	286	31	assay	assay	NN
cord-300872-blycbi4u	286	32	.	.	.
cord-300872-blycbi4u	287	1	The	the	DT
cord-300872-blycbi4u	287	2	results	result	NNS
cord-300872-blycbi4u	287	3	revealed	reveal	VBD
cord-300872-blycbi4u	287	4	that	that	IN
cord-300872-blycbi4u	287	5	all	all	DT
cord-300872-blycbi4u	287	6	products	product	NNS
cord-300872-blycbi4u	287	7	showed	show	VBD
cord-300872-blycbi4u	287	8	low	low	JJ
cord-300872-blycbi4u	287	9	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	287	10	activity	activity	NN
cord-300872-blycbi4u	287	11	,	,	,
cord-300872-blycbi4u	287	12	with	with	IN
cord-300872-blycbi4u	287	13	IC50	ic50	JJ
cord-300872-blycbi4u	287	14	values	value	NNS
cord-300872-blycbi4u	287	15	of	of	IN
cord-300872-blycbi4u	287	16	0.8	0.8	CD
cord-300872-blycbi4u	287	17	-	-	HYPH
cord-300872-blycbi4u	287	18	2.49	2.49	CD
cord-300872-blycbi4u	287	19	mg	mg	NNP
cord-300872-blycbi4u	287	20	/	/	SYM
cord-300872-blycbi4u	287	21	mL	mL	NNP
cord-300872-blycbi4u	287	22	,	,	,
cord-300872-blycbi4u	287	23	whereas	whereas	IN
cord-300872-blycbi4u	287	24	the	the	DT
cord-300872-blycbi4u	287	25	IC50	IC50	NNP
cord-300872-blycbi4u	287	26	value	value	NN
cord-300872-blycbi4u	287	27	of	of	IN
cord-300872-blycbi4u	287	28	1-ascorbic	1-ascorbic	CD
cord-300872-blycbi4u	287	29	acid	acid	NN
cord-300872-blycbi4u	287	30	was	be	VBD
cord-300872-blycbi4u	287	31	0.1	0.1	CD
cord-300872-blycbi4u	287	32	mg	mg	NNP
cord-300872-blycbi4u	287	33	/	/	SYM
cord-300872-blycbi4u	287	34	mL.	ml.	NN
cord-300872-blycbi4u	288	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	288	2	,	,	,
cord-300872-blycbi4u	288	3	the	the	DT
cord-300872-blycbi4u	288	4	results	result	NNS
cord-300872-blycbi4u	288	5	showed	show	VBD
cord-300872-blycbi4u	288	6	that	that	IN
cord-300872-blycbi4u	288	7	as	as	IN
cord-300872-blycbi4u	288	8	the	the	DT
cord-300872-blycbi4u	288	9	number	number	NN
cord-300872-blycbi4u	288	10	of	of	IN
cord-300872-blycbi4u	288	11	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	288	12	groups	group	NNS
cord-300872-blycbi4u	288	13	increases	increase	VBZ
cord-300872-blycbi4u	288	14	,	,	,
cord-300872-blycbi4u	288	15	the	the	DT
cord-300872-blycbi4u	288	16	inhibition	inhibition	NN
cord-300872-blycbi4u	288	17	activity	activity	NN
cord-300872-blycbi4u	288	18	increases	increase	VBZ
cord-300872-blycbi4u	288	19	too	too	RB
cord-300872-blycbi4u	288	20	.	.	.
cord-300872-blycbi4u	289	1	[	[	-LRB-
cord-300872-blycbi4u	289	2	24	24	CD
cord-300872-blycbi4u	289	3	]	]	-RRB-
cord-300872-blycbi4u	289	4	following	follow	VBG
cord-300872-blycbi4u	289	5	a	a	DT
cord-300872-blycbi4u	289	6	published	publish	VBN
cord-300872-blycbi4u	289	7	procedure	procedure	NN
cord-300872-blycbi4u	289	8	[	[	-LRB-
cord-300872-blycbi4u	289	9	25	25	CD
cord-300872-blycbi4u	289	10	]	]	-RRB-
cord-300872-blycbi4u	289	11	.	.	.
cord-300872-blycbi4u	290	1	The	the	DT
cord-300872-blycbi4u	290	2	structures	structure	NNS
cord-300872-blycbi4u	290	3	of	of	IN
cord-300872-blycbi4u	290	4	prepared	prepared	JJ
cord-300872-blycbi4u	290	5	compounds	compound	NNS
cord-300872-blycbi4u	290	6	were	be	VBD
cord-300872-blycbi4u	290	7	confirmed	confirm	VBN
cord-300872-blycbi4u	290	8	with	with	IN
cord-300872-blycbi4u	290	9	the	the	DT
cord-300872-blycbi4u	290	10	aid	aid	NN
cord-300872-blycbi4u	290	11	of	of	IN
cord-300872-blycbi4u	290	12	a	a	DT
cord-300872-blycbi4u	290	13	panel	panel	NN
cord-300872-blycbi4u	290	14	of	of	IN
cord-300872-blycbi4u	290	15	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	290	16	methods	method	NNS
cord-300872-blycbi4u	290	17	,	,	,
cord-300872-blycbi4u	290	18	including	include	VBG
cord-300872-blycbi4u	290	19	1	1	CD
cord-300872-blycbi4u	290	20	H	h	NN
cord-300872-blycbi4u	290	21	NMR	nmr	NN
cord-300872-blycbi4u	290	22	,	,	,
cord-300872-blycbi4u	290	23	13	13	CD
cord-300872-blycbi4u	290	24	The	the	DT
cord-300872-blycbi4u	290	25	prepared	prepared	JJ
cord-300872-blycbi4u	290	26	compounds	compound	NNS
cord-300872-blycbi4u	290	27	were	be	VBD
cord-300872-blycbi4u	290	28	then	then	RB
cord-300872-blycbi4u	290	29	subjected	subject	VBN
cord-300872-blycbi4u	290	30	to	to	IN
cord-300872-blycbi4u	290	31	cell	cell	NN
cord-300872-blycbi4u	290	32	viability	viability	NN
cord-300872-blycbi4u	290	33	evaluation	evaluation	NN
cord-300872-blycbi4u	290	34	against	against	IN
cord-300872-blycbi4u	290	35	Hela	Hela	NNP
cord-300872-blycbi4u	290	36	,	,	,
cord-300872-blycbi4u	291	1	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	291	2	,	,	,
cord-300872-blycbi4u	291	3	A-549	a-549	NN
cord-300872-blycbi4u	291	4	,	,	,
cord-300872-blycbi4u	291	5	and	and	CC
cord-300872-blycbi4u	291	6	MDA	MDA	NNP
cord-300872-blycbi4u	291	7	-	-	HYPH
cord-300872-blycbi4u	291	8	MB-231	MB-231	NNP
cord-300872-blycbi4u	291	9	(	(	-LRB-
cord-300872-blycbi4u	291	10	triple	triple	JJ
cord-300872-blycbi4u	291	11	-	-	HYPH
cord-300872-blycbi4u	291	12	negative	negative	JJ
cord-300872-blycbi4u	291	13	breast	breast	NN
cord-300872-blycbi4u	291	14	cancer	cancer	NN
cord-300872-blycbi4u	291	15	cell	cell	NN
cord-300872-blycbi4u	291	16	line	line	NN
cord-300872-blycbi4u	291	17	)	)	-RRB-
cord-300872-blycbi4u	291	18	cell	cell	NN
cord-300872-blycbi4u	291	19	lines	line	NNS
cord-300872-blycbi4u	291	20	using	use	VBG
cord-300872-blycbi4u	291	21	the	the	DT
cord-300872-blycbi4u	291	22	MTT	MTT	NNP
cord-300872-blycbi4u	291	23	assay	assay	NN
cord-300872-blycbi4u	291	24	[	[	-LRB-
cord-300872-blycbi4u	291	25	26	26	CD
cord-300872-blycbi4u	291	26	]	]	-RRB-
cord-300872-blycbi4u	292	1	[	[	-LRB-
cord-300872-blycbi4u	292	2	27	27	CD
cord-300872-blycbi4u	292	3	]	]	-RRB-
cord-300872-blycbi4u	292	4	[	[	-LRB-
cord-300872-blycbi4u	292	5	28	28	CD
cord-300872-blycbi4u	292	6	]	]	-RRB-
cord-300872-blycbi4u	292	7	at	at	IN
cord-300872-blycbi4u	292	8	a	a	DT
cord-300872-blycbi4u	292	9	concentration	concentration	NN
cord-300872-blycbi4u	292	10	of	of	IN
cord-300872-blycbi4u	292	11	20	20	CD
cord-300872-blycbi4u	292	12	mM.	mM.	NNS
cord-300872-blycbi4u	293	1	The	the	DT
cord-300872-blycbi4u	293	2	results	result	NNS
cord-300872-blycbi4u	293	3	revealed	reveal	VBD
cord-300872-blycbi4u	293	4	that	that	IN
cord-300872-blycbi4u	293	5	only	only	RB
cord-300872-blycbi4u	293	6	4	4	CD
cord-300872-blycbi4u	293	7	compounds	compound	NNS
cord-300872-blycbi4u	293	8	designated	designate	VBN
cord-300872-blycbi4u	293	9	with	with	IN
cord-300872-blycbi4u	293	10	R	r	NN
cord-300872-blycbi4u	293	11	=	=	SYM
cord-300872-blycbi4u	293	12	phenyl	phenyl	NN
cord-300872-blycbi4u	293	13	,	,	,
cord-300872-blycbi4u	293	14	3,5-dimethylphenyl	3,5-dimethylphenyl	CD
cord-300872-blycbi4u	293	15	,	,	,
cord-300872-blycbi4u	293	16	4-fluorophenyl	4-fluorophenyl	CD
cord-300872-blycbi4u	293	17	,	,	,
cord-300872-blycbi4u	293	18	and	and	CC
cord-300872-blycbi4u	293	19	4-trifluoromethylphenyl	4-trifluoromethylphenyl	CD
cord-300872-blycbi4u	293	20	exhibited	exhibit	VBD
cord-300872-blycbi4u	293	21	significantly	significantly	RB
cord-300872-blycbi4u	293	22	reduced	reduce	VBN
cord-300872-blycbi4u	293	23	cell	cell	NN
cord-300872-blycbi4u	293	24	viability	viability	NN
cord-300872-blycbi4u	293	25	percentages	percentage	NNS
cord-300872-blycbi4u	293	26	towards	towards	IN
cord-300872-blycbi4u	293	27	the	the	DT
cord-300872-blycbi4u	293	28	tested	test	VBN
cord-300872-blycbi4u	293	29	cancer	cancer	NN
cord-300872-blycbi4u	293	30	cell	cell	NN
cord-300872-blycbi4u	293	31	lines	line	NNS
cord-300872-blycbi4u	293	32	.	.	.
cord-300872-blycbi4u	294	1	The	the	DT
cord-300872-blycbi4u	294	2	IC50	IC50	NNP
cord-300872-blycbi4u	294	3	values	value	NNS
cord-300872-blycbi4u	294	4	for	for	IN
cord-300872-blycbi4u	294	5	these	these	DT
cord-300872-blycbi4u	294	6	compounds	compound	NNS
cord-300872-blycbi4u	294	7	were	be	VBD
cord-300872-blycbi4u	294	8	between	between	IN
cord-300872-blycbi4u	294	9	26.30	26.30	CD
cord-300872-blycbi4u	294	10	and	and	CC
cord-300872-blycbi4u	294	11	63.75	63.75	CD
cord-300872-blycbi4u	294	12	mM	mm	CD
cord-300872-blycbi4u	294	13	against	against	IN
cord-300872-blycbi4u	294	14	selected	select	VBN
cord-300872-blycbi4u	294	15	cancer	cancer	NN
cord-300872-blycbi4u	294	16	cell	cell	NN
cord-300872-blycbi4u	294	17	lines	line	NNS
cord-300872-blycbi4u	294	18	,	,	,
cord-300872-blycbi4u	294	19	whereas	whereas	IN
cord-300872-blycbi4u	294	20	the	the	DT
cord-300872-blycbi4u	294	21	IC50	IC50	NNP
cord-300872-blycbi4u	294	22	of	of	IN
cord-300872-blycbi4u	294	23	docetaxel	docetaxel	NNP
cord-300872-blycbi4u	294	24	(	(	-LRB-
cord-300872-blycbi4u	294	25	positive	positive	JJ
cord-300872-blycbi4u	294	26	control	control	NN
cord-300872-blycbi4u	294	27	)	)	-RRB-
cord-300872-blycbi4u	294	28	was	be	VBD
cord-300872-blycbi4u	294	29	in	in	IN
cord-300872-blycbi4u	294	30	the	the	DT
cord-300872-blycbi4u	294	31	range	range	NN
cord-300872-blycbi4u	294	32	of	of	IN
cord-300872-blycbi4u	294	33	3.37	3.37	CD
cord-300872-blycbi4u	294	34	-	-	SYM
cord-300872-blycbi4u	294	35	4.46	4.46	CD
cord-300872-blycbi4u	295	1	mM.	mM.	NNP
cord-300872-blycbi4u	295	2	A	a	DT
cord-300872-blycbi4u	295	3	new	new	JJ
cord-300872-blycbi4u	295	4	series	series	NN
cord-300872-blycbi4u	295	5	of	of	IN
cord-300872-blycbi4u	295	6	glycoconjugates	glycoconjugates	NNPS
cord-300872-blycbi4u	295	7	composed	compose	VBN
cord-300872-blycbi4u	295	8	of	of	IN
cord-300872-blycbi4u	295	9	various	various	JJ
cord-300872-blycbi4u	295	10	sugar	sugar	NN
cord-300872-blycbi4u	295	11	units	unit	NNS
cord-300872-blycbi4u	295	12	(	(	-LRB-
cord-300872-blycbi4u	295	13	40	40	CD
cord-300872-blycbi4u	295	14	,	,	,
cord-300872-blycbi4u	295	15	41	41	CD
cord-300872-blycbi4u	295	16	)	)	-RRB-
cord-300872-blycbi4u	296	1	(	(	-LRB-
cord-300872-blycbi4u	296	2	D	d	NN
cord-300872-blycbi4u	296	3	-	-	HYPH
cord-300872-blycbi4u	296	4	glucose	glucose	NN
cord-300872-blycbi4u	296	5	or	or	CC
cord-300872-blycbi4u	296	6	Dgalactose	Dgalactose	NNP
cord-300872-blycbi4u	296	7	)	)	-RRB-
cord-300872-blycbi4u	296	8	and	and	CC
cord-300872-blycbi4u	296	9	8-hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	296	10	(	(	-LRB-
cord-300872-blycbi4u	296	11	42	42	CD
cord-300872-blycbi4u	296	12	,	,	,
cord-300872-blycbi4u	296	13	43	43	CD
cord-300872-blycbi4u	296	14	)	)	-RRB-
cord-300872-blycbi4u	296	15	was	be	VBD
cord-300872-blycbi4u	296	16	prepared	prepare	VBN
cord-300872-blycbi4u	296	17	in	in	IN
cord-300872-blycbi4u	296	18	an	an	DT
cord-300872-blycbi4u	296	19	effective	effective	JJ
cord-300872-blycbi4u	296	20	and	and	CC
cord-300872-blycbi4u	296	21	simple	simple	JJ
cord-300872-blycbi4u	296	22	method	method	NN
cord-300872-blycbi4u	296	23	[	[	-LRB-
cord-300872-blycbi4u	296	24	29	29	CD
cord-300872-blycbi4u	296	25	]	]	-RRB-
cord-300872-blycbi4u	296	26	.	.	.
cord-300872-blycbi4u	297	1	The	the	DT
cord-300872-blycbi4u	297	2	connection	connection	NN
cord-300872-blycbi4u	297	3	between	between	IN
cord-300872-blycbi4u	297	4	these	these	DT
cord-300872-blycbi4u	297	5	units	unit	NNS
cord-300872-blycbi4u	297	6	was	be	VBD
cord-300872-blycbi4u	297	7	accomplished	accomplish	VBN
cord-300872-blycbi4u	297	8	by	by	IN
cord-300872-blycbi4u	297	9	O	o	NN
cord-300872-blycbi4u	297	10	-	-	HYPH
cord-300872-blycbi4u	297	11	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	297	12	bond	bond	NN
cord-300872-blycbi4u	297	13	or	or	CC
cord-300872-blycbi4u	297	14	via	via	IN
cord-300872-blycbi4u	297	15	O	o	NN
cord-300872-blycbi4u	297	16	-	-	HYPH
cord-300872-blycbi4u	297	17	methylene	methylene	NN
cord-300872-blycbi4u	297	18	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	297	19	linker	linker	NN
cord-300872-blycbi4u	297	20	,	,	,
cord-300872-blycbi4u	297	21	as	as	IN
cord-300872-blycbi4u	297	22	shown	show	VBN
cord-300872-blycbi4u	297	23	in	in	IN
cord-300872-blycbi4u	297	24	Scheme	Scheme	NNP
cord-300872-blycbi4u	297	25	11	11	CD
cord-300872-blycbi4u	297	26	.	.	.
cord-300872-blycbi4u	298	1	Sugar	sugar	NN
cord-300872-blycbi4u	298	2	derivatives	derivative	NNS
cord-300872-blycbi4u	298	3	of	of	IN
cord-300872-blycbi4u	298	4	44	44	CD
cord-300872-blycbi4u	298	5	and	and	CC
cord-300872-blycbi4u	298	6	45	45	CD
cord-300872-blycbi4u	298	7	were	be	VBD
cord-300872-blycbi4u	298	8	prepared	prepare	VBN
cord-300872-blycbi4u	298	9	according	accord	VBG
cord-300872-blycbi4u	298	10	to	to	IN
cord-300872-blycbi4u	298	11	published	publish	VBN
cord-300872-blycbi4u	298	12	procedures	procedure	NNS
cord-300872-blycbi4u	298	13	[	[	-LRB-
cord-300872-blycbi4u	298	14	30	30	CD
cord-300872-blycbi4u	298	15	]	]	-RRB-
cord-300872-blycbi4u	299	1	[	[	-LRB-
cord-300872-blycbi4u	299	2	31	31	CD
cord-300872-blycbi4u	299	3	]	]	-RRB-
cord-300872-blycbi4u	299	4	[	[	-LRB-
cord-300872-blycbi4u	299	5	32	32	CD
cord-300872-blycbi4u	299	6	]	]	-RRB-
cord-300872-blycbi4u	299	7	;	;	:
cord-300872-blycbi4u	299	8	sugar	sugar	NN
cord-300872-blycbi4u	299	9	was	be	VBD
cord-300872-blycbi4u	299	10	used	use	VBN
cord-300872-blycbi4u	299	11	to	to	TO
cord-300872-blycbi4u	299	12	enhance	enhance	VB
cord-300872-blycbi4u	299	13	the	the	DT
cord-300872-blycbi4u	299	14	bioavailability	bioavailability	NN
cord-300872-blycbi4u	299	15	and	and	CC
cord-300872-blycbi4u	299	16	solubility	solubility	NN
cord-300872-blycbi4u	299	17	of	of	IN
cord-300872-blycbi4u	299	18	potential	potential	JJ
cord-300872-blycbi4u	299	19	drugs	drug	NNS
cord-300872-blycbi4u	299	20	.	.	.
cord-300872-blycbi4u	300	1	(	(	-LRB-
cord-300872-blycbi4u	300	2	Figure	figure	NN
cord-300872-blycbi4u	300	3	3	3	CD
cord-300872-blycbi4u	300	4	)	)	-RRB-
cord-300872-blycbi4u	300	5	in	in	IN
cord-300872-blycbi4u	300	6	moderate	moderate	JJ
cord-300872-blycbi4u	300	7	to	to	IN
cord-300872-blycbi4u	300	8	excellent	excellent	JJ
cord-300872-blycbi4u	300	9	yields	yield	NNS
cord-300872-blycbi4u	300	10	[	[	-LRB-
cord-300872-blycbi4u	300	11	24	24	CD
cord-300872-blycbi4u	300	12	]	]	-RRB-
cord-300872-blycbi4u	300	13	following	follow	VBG
cord-300872-blycbi4u	300	14	a	a	DT
cord-300872-blycbi4u	300	15	published	publish	VBN
cord-300872-blycbi4u	300	16	procedure	procedure	NN
cord-300872-blycbi4u	300	17	[	[	-LRB-
cord-300872-blycbi4u	300	18	25	25	CD
cord-300872-blycbi4u	300	19	]	]	-RRB-
cord-300872-blycbi4u	300	20	.	.	.
cord-300872-blycbi4u	301	1	The	the	DT
cord-300872-blycbi4u	301	2	structures	structure	NNS
cord-300872-blycbi4u	301	3	of	of	IN
cord-300872-blycbi4u	301	4	prepared	prepared	JJ
cord-300872-blycbi4u	301	5	compounds	compound	NNS
cord-300872-blycbi4u	301	6	were	be	VBD
cord-300872-blycbi4u	301	7	confirmed	confirm	VBN
cord-300872-blycbi4u	301	8	with	with	IN
cord-300872-blycbi4u	301	9	the	the	DT
cord-300872-blycbi4u	301	10	aid	aid	NN
cord-300872-blycbi4u	301	11	of	of	IN
cord-300872-blycbi4u	301	12	a	a	DT
cord-300872-blycbi4u	301	13	panel	panel	NN
cord-300872-blycbi4u	301	14	of	of	IN
cord-300872-blycbi4u	301	15	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	301	16	methods	method	NNS
cord-300872-blycbi4u	301	17	,	,	,
cord-300872-blycbi4u	301	18	including	include	VBG
cord-300872-blycbi4u	301	19	1	1	CD
cord-300872-blycbi4u	301	20	H	h	NN
cord-300872-blycbi4u	301	21	NMR	nmr	NN
cord-300872-blycbi4u	301	22	,	,	,
cord-300872-blycbi4u	301	23	13	13	CD
cord-300872-blycbi4u	301	24	C	c	NN
cord-300872-blycbi4u	301	25	NMR	NMR	NNP
cord-300872-blycbi4u	301	26	,	,	,
cord-300872-blycbi4u	301	27	IR	IR	NNP
cord-300872-blycbi4u	301	28	,	,	,
cord-300872-blycbi4u	301	29	and	and	CC
cord-300872-blycbi4u	301	30	HRMS	HRMS	NNP
cord-300872-blycbi4u	301	31	.	.	.
cord-300872-blycbi4u	302	1	Molecules	molecule	NNS
cord-300872-blycbi4u	302	2	2020	2020	CD
cord-300872-blycbi4u	302	3	,	,	,
cord-300872-blycbi4u	302	4	25	25	CD
cord-300872-blycbi4u	302	5	,	,	,
cord-300872-blycbi4u	302	6	x	x	NN
cord-300872-blycbi4u	302	7	FOR	for	IN
cord-300872-blycbi4u	302	8	PEER	PEER	NNP
cord-300872-blycbi4u	302	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	302	10	10	10	CD
cord-300872-blycbi4u	302	11	of	of	IN
cord-300872-blycbi4u	302	12	26	26	CD
cord-300872-blycbi4u	302	13	Faydy	Faydy	NNP
cord-300872-blycbi4u	302	14	and	and	CC
cord-300872-blycbi4u	302	15	coworkers	coworker	NNS
cord-300872-blycbi4u	302	16	described	describe	VBD
cord-300872-blycbi4u	302	17	the	the	DT
cord-300872-blycbi4u	302	18	synthesis	synthesis	NN
cord-300872-blycbi4u	302	19	of	of	IN
cord-300872-blycbi4u	302	20	new	new	JJ
cord-300872-blycbi4u	302	21	derivatives	derivative	NNS
cord-300872-blycbi4u	302	22	of	of	IN
cord-300872-blycbi4u	302	23	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	302	24	(	(	-LRB-
cord-300872-blycbi4u	302	25	36	36	CD
cord-300872-blycbi4u	302	26	-	-	SYM
cord-300872-blycbi4u	302	27	38	38	CD
cord-300872-blycbi4u	302	28	)	)	-RRB-
cord-300872-blycbi4u	302	29	(	(	-LRB-
cord-300872-blycbi4u	302	30	Figure	figure	NN
cord-300872-blycbi4u	302	31	2	2	CD
cord-300872-blycbi4u	302	32	)	)	-RRB-
cord-300872-blycbi4u	302	33	in	in	IN
cord-300872-blycbi4u	302	34	a	a	DT
cord-300872-blycbi4u	302	35	multistep	multistep	JJ
cord-300872-blycbi4u	302	36	approach	approach	NN
cord-300872-blycbi4u	302	37	[	[	-LRB-
cord-300872-blycbi4u	302	38	20	20	CD
cord-300872-blycbi4u	302	39	]	]	-RRB-
cord-300872-blycbi4u	302	40	according	accord	VBG
cord-300872-blycbi4u	302	41	to	to	IN
cord-300872-blycbi4u	302	42	published	publish	VBN
cord-300872-blycbi4u	302	43	procedures	procedure	NNS
cord-300872-blycbi4u	302	44	[	[	-LRB-
cord-300872-blycbi4u	302	45	21	21	CD
cord-300872-blycbi4u	302	46	]	]	-RRB-
cord-300872-blycbi4u	302	47	[	[	-LRB-
cord-300872-blycbi4u	302	48	22	22	CD
cord-300872-blycbi4u	302	49	]	]	-RRB-
cord-300872-blycbi4u	302	50	[	[	-LRB-
cord-300872-blycbi4u	302	51	23	23	CD
cord-300872-blycbi4u	302	52	]	]	-RRB-
cord-300872-blycbi4u	302	53	.	.	.
cord-300872-blycbi4u	303	1	The	the	DT
cord-300872-blycbi4u	303	2	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	303	3	activity	activity	NN
cord-300872-blycbi4u	303	4	of	of	IN
cord-300872-blycbi4u	303	5	prepared	prepared	JJ
cord-300872-blycbi4u	303	6	products	product	NNS
cord-300872-blycbi4u	303	7	,	,	,
cord-300872-blycbi4u	303	8	along	along	IN
cord-300872-blycbi4u	303	9	with	with	IN
cord-300872-blycbi4u	303	10	L	l	NN
cord-300872-blycbi4u	303	11	-	-	HYPH
cord-300872-blycbi4u	303	12	ascorbic	ascorbic	NN
cord-300872-blycbi4u	303	13	acid	acid	NN
cord-300872-blycbi4u	303	14	,	,	,
cord-300872-blycbi4u	303	15	was	be	VBD
cord-300872-blycbi4u	303	16	evaluated	evaluate	VBN
cord-300872-blycbi4u	303	17	by	by	IN
cord-300872-blycbi4u	303	18	means	mean	NNS
cord-300872-blycbi4u	303	19	of	of	IN
cord-300872-blycbi4u	303	20	the	the	DT
cord-300872-blycbi4u	303	21	free	free	JJ
cord-300872-blycbi4u	303	22	radical	radical	JJ
cord-300872-blycbi4u	303	23	scavenging	scavenging	NN
cord-300872-blycbi4u	303	24	method	method	NN
cord-300872-blycbi4u	303	25	using	use	VBG
cord-300872-blycbi4u	303	26	the	the	DT
cord-300872-blycbi4u	303	27	2,2-diphenyl-1-picryhydrazyl	2,2-diphenyl-1-picryhydrazyl	CD
cord-300872-blycbi4u	303	28	(	(	-LRB-
cord-300872-blycbi4u	303	29	DPPH	DPPH	NNP
cord-300872-blycbi4u	303	30	)	)	-RRB-
cord-300872-blycbi4u	303	31	assay	assay	NN
cord-300872-blycbi4u	303	32	.	.	.
cord-300872-blycbi4u	304	1	The	the	DT
cord-300872-blycbi4u	304	2	results	result	NNS
cord-300872-blycbi4u	304	3	revealed	reveal	VBD
cord-300872-blycbi4u	304	4	that	that	IN
cord-300872-blycbi4u	304	5	all	all	DT
cord-300872-blycbi4u	304	6	products	product	NNS
cord-300872-blycbi4u	304	7	showed	show	VBD
cord-300872-blycbi4u	304	8	low	low	JJ
cord-300872-blycbi4u	304	9	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	304	10	activity	activity	NN
cord-300872-blycbi4u	304	11	,	,	,
cord-300872-blycbi4u	304	12	with	with	IN
cord-300872-blycbi4u	304	13	IC50	ic50	JJ
cord-300872-blycbi4u	304	14	values	value	NNS
cord-300872-blycbi4u	304	15	of	of	IN
cord-300872-blycbi4u	304	16	0.8	0.8	CD
cord-300872-blycbi4u	304	17	-	-	HYPH
cord-300872-blycbi4u	304	18	2.49	2.49	CD
cord-300872-blycbi4u	304	19	mg	mg	NNP
cord-300872-blycbi4u	304	20	/	/	SYM
cord-300872-blycbi4u	304	21	mL	mL	NNP
cord-300872-blycbi4u	304	22	,	,	,
cord-300872-blycbi4u	304	23	whereas	whereas	IN
cord-300872-blycbi4u	304	24	the	the	DT
cord-300872-blycbi4u	304	25	IC50	IC50	NNP
cord-300872-blycbi4u	304	26	value	value	NN
cord-300872-blycbi4u	304	27	of	of	IN
cord-300872-blycbi4u	304	28	1-ascorbic	1-ascorbic	CD
cord-300872-blycbi4u	304	29	acid	acid	NN
cord-300872-blycbi4u	304	30	was	be	VBD
cord-300872-blycbi4u	304	31	0.1	0.1	CD
cord-300872-blycbi4u	304	32	mg	mg	NNP
cord-300872-blycbi4u	304	33	/	/	SYM
cord-300872-blycbi4u	304	34	mL.	ml.	NN
cord-300872-blycbi4u	305	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	305	2	,	,	,
cord-300872-blycbi4u	305	3	the	the	DT
cord-300872-blycbi4u	305	4	results	result	NNS
cord-300872-blycbi4u	305	5	showed	show	VBD
cord-300872-blycbi4u	305	6	that	that	IN
cord-300872-blycbi4u	305	7	as	as	IN
cord-300872-blycbi4u	305	8	the	the	DT
cord-300872-blycbi4u	305	9	number	number	NN
cord-300872-blycbi4u	305	10	of	of	IN
cord-300872-blycbi4u	305	11	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	305	12	groups	group	NNS
cord-300872-blycbi4u	305	13	increases	increase	VBZ
cord-300872-blycbi4u	305	14	,	,	,
cord-300872-blycbi4u	305	15	the	the	DT
cord-300872-blycbi4u	305	16	inhibition	inhibition	NN
cord-300872-blycbi4u	305	17	activity	activity	NN
cord-300872-blycbi4u	305	18	increases	increase	VBZ
cord-300872-blycbi4u	305	19	too	too	RB
cord-300872-blycbi4u	305	20	.	.	.
cord-300872-blycbi4u	306	1	(	(	-LRB-
cord-300872-blycbi4u	306	2	Figure	figure	NN
cord-300872-blycbi4u	306	3	3	3	CD
cord-300872-blycbi4u	306	4	)	)	-RRB-
cord-300872-blycbi4u	306	5	in	in	IN
cord-300872-blycbi4u	306	6	moderate	moderate	JJ
cord-300872-blycbi4u	306	7	to	to	IN
cord-300872-blycbi4u	306	8	excellent	excellent	JJ
cord-300872-blycbi4u	306	9	yields	yield	NNS
cord-300872-blycbi4u	306	10	[	[	-LRB-
cord-300872-blycbi4u	306	11	24	24	CD
cord-300872-blycbi4u	306	12	]	]	-RRB-
cord-300872-blycbi4u	306	13	following	follow	VBG
cord-300872-blycbi4u	306	14	a	a	DT
cord-300872-blycbi4u	306	15	published	publish	VBN
cord-300872-blycbi4u	306	16	procedure	procedure	NN
cord-300872-blycbi4u	306	17	[	[	-LRB-
cord-300872-blycbi4u	306	18	25	25	CD
cord-300872-blycbi4u	306	19	]	]	-RRB-
cord-300872-blycbi4u	306	20	.	.	.
cord-300872-blycbi4u	307	1	The	the	DT
cord-300872-blycbi4u	307	2	structures	structure	NNS
cord-300872-blycbi4u	307	3	of	of	IN
cord-300872-blycbi4u	307	4	prepared	prepared	JJ
cord-300872-blycbi4u	307	5	compounds	compound	NNS
cord-300872-blycbi4u	307	6	were	be	VBD
cord-300872-blycbi4u	307	7	confirmed	confirm	VBN
cord-300872-blycbi4u	307	8	with	with	IN
cord-300872-blycbi4u	307	9	the	the	DT
cord-300872-blycbi4u	307	10	aid	aid	NN
cord-300872-blycbi4u	307	11	of	of	IN
cord-300872-blycbi4u	307	12	a	a	DT
cord-300872-blycbi4u	307	13	panel	panel	NN
cord-300872-blycbi4u	307	14	of	of	IN
cord-300872-blycbi4u	307	15	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	307	16	methods	method	NNS
cord-300872-blycbi4u	307	17	,	,	,
cord-300872-blycbi4u	307	18	including	include	VBG
cord-300872-blycbi4u	307	19	1	1	CD
cord-300872-blycbi4u	307	20	H	h	NN
cord-300872-blycbi4u	307	21	NMR	nmr	NN
cord-300872-blycbi4u	307	22	,	,	,
cord-300872-blycbi4u	307	23	13	13	CD
cord-300872-blycbi4u	307	24	(	(	-LRB-
cord-300872-blycbi4u	307	25	42	42	CD
cord-300872-blycbi4u	307	26	,	,	,
cord-300872-blycbi4u	307	27	43	43	CD
cord-300872-blycbi4u	307	28	)	)	-RRB-
cord-300872-blycbi4u	307	29	was	be	VBD
cord-300872-blycbi4u	307	30	prepared	prepare	VBN
cord-300872-blycbi4u	307	31	in	in	IN
cord-300872-blycbi4u	307	32	an	an	DT
cord-300872-blycbi4u	307	33	effective	effective	JJ
cord-300872-blycbi4u	307	34	and	and	CC
cord-300872-blycbi4u	307	35	simple	simple	JJ
cord-300872-blycbi4u	307	36	method	method	NN
cord-300872-blycbi4u	307	37	[	[	-LRB-
cord-300872-blycbi4u	307	38	29	29	CD
cord-300872-blycbi4u	307	39	]	]	-RRB-
cord-300872-blycbi4u	307	40	.	.	.
cord-300872-blycbi4u	308	1	The	the	DT
cord-300872-blycbi4u	308	2	connection	connection	NN
cord-300872-blycbi4u	308	3	between	between	IN
cord-300872-blycbi4u	308	4	these	these	DT
cord-300872-blycbi4u	308	5	units	unit	NNS
cord-300872-blycbi4u	308	6	was	be	VBD
cord-300872-blycbi4u	308	7	accomplished	accomplish	VBN
cord-300872-blycbi4u	308	8	by	by	IN
cord-300872-blycbi4u	308	9	O	o	NN
cord-300872-blycbi4u	308	10	-	-	HYPH
cord-300872-blycbi4u	308	11	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	308	12	bond	bond	NN
cord-300872-blycbi4u	308	13	or	or	CC
cord-300872-blycbi4u	308	14	via	via	IN
cord-300872-blycbi4u	308	15	O	o	NN
cord-300872-blycbi4u	308	16	-	-	HYPH
cord-300872-blycbi4u	308	17	methylene	methylene	NN
cord-300872-blycbi4u	308	18	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	308	19	linker	linker	NN
cord-300872-blycbi4u	308	20	,	,	,
cord-300872-blycbi4u	308	21	as	as	IN
cord-300872-blycbi4u	308	22	shown	show	VBN
cord-300872-blycbi4u	308	23	in	in	IN
cord-300872-blycbi4u	308	24	Scheme	Scheme	NNP
cord-300872-blycbi4u	308	25	11	11	CD
cord-300872-blycbi4u	308	26	.	.	.
cord-300872-blycbi4u	309	1	Sugar	sugar	NN
cord-300872-blycbi4u	309	2	derivatives	derivative	NNS
cord-300872-blycbi4u	309	3	of	of	IN
cord-300872-blycbi4u	309	4	44	44	CD
cord-300872-blycbi4u	309	5	and	and	CC
cord-300872-blycbi4u	309	6	45	45	CD
cord-300872-blycbi4u	309	7	were	be	VBD
cord-300872-blycbi4u	309	8	prepared	prepare	VBN
cord-300872-blycbi4u	309	9	according	accord	VBG
cord-300872-blycbi4u	309	10	to	to	IN
cord-300872-blycbi4u	309	11	published	publish	VBN
cord-300872-blycbi4u	309	12	procedures	procedure	NNS
cord-300872-blycbi4u	309	13	[	[	-LRB-
cord-300872-blycbi4u	309	14	30	30	CD
cord-300872-blycbi4u	309	15	]	]	-RRB-
cord-300872-blycbi4u	310	1	[	[	-LRB-
cord-300872-blycbi4u	310	2	31	31	CD
cord-300872-blycbi4u	310	3	]	]	-RRB-
cord-300872-blycbi4u	310	4	[	[	-LRB-
cord-300872-blycbi4u	310	5	32	32	CD
cord-300872-blycbi4u	310	6	]	]	-RRB-
cord-300872-blycbi4u	310	7	;	;	:
cord-300872-blycbi4u	310	8	sugar	sugar	NN
cord-300872-blycbi4u	310	9	was	be	VBD
cord-300872-blycbi4u	310	10	used	use	VBN
cord-300872-blycbi4u	310	11	to	to	TO
cord-300872-blycbi4u	310	12	enhance	enhance	VB
cord-300872-blycbi4u	310	13	the	the	DT
cord-300872-blycbi4u	310	14	bioavailability	bioavailability	NN
cord-300872-blycbi4u	310	15	and	and	CC
cord-300872-blycbi4u	310	16	solubility	solubility	NN
cord-300872-blycbi4u	310	17	of	of	IN
cord-300872-blycbi4u	310	18	potential	potential	JJ
cord-300872-blycbi4u	310	19	drugs	drug	NNS
cord-300872-blycbi4u	310	20	.	.	.
cord-300872-blycbi4u	311	1	(	(	-LRB-
cord-300872-blycbi4u	311	2	42	42	CD
cord-300872-blycbi4u	311	3	,	,	,
cord-300872-blycbi4u	311	4	43	43	CD
cord-300872-blycbi4u	311	5	)	)	-RRB-
cord-300872-blycbi4u	311	6	was	be	VBD
cord-300872-blycbi4u	311	7	prepared	prepare	VBN
cord-300872-blycbi4u	311	8	in	in	IN
cord-300872-blycbi4u	311	9	an	an	DT
cord-300872-blycbi4u	311	10	effective	effective	JJ
cord-300872-blycbi4u	311	11	and	and	CC
cord-300872-blycbi4u	311	12	simple	simple	JJ
cord-300872-blycbi4u	311	13	method	method	NN
cord-300872-blycbi4u	311	14	[	[	-LRB-
cord-300872-blycbi4u	311	15	29	29	CD
cord-300872-blycbi4u	311	16	]	]	-RRB-
cord-300872-blycbi4u	311	17	.	.	.
cord-300872-blycbi4u	312	1	The	the	DT
cord-300872-blycbi4u	312	2	connection	connection	NN
cord-300872-blycbi4u	312	3	between	between	IN
cord-300872-blycbi4u	312	4	these	these	DT
cord-300872-blycbi4u	312	5	units	unit	NNS
cord-300872-blycbi4u	312	6	was	be	VBD
cord-300872-blycbi4u	312	7	accomplished	accomplish	VBN
cord-300872-blycbi4u	312	8	by	by	IN
cord-300872-blycbi4u	312	9	O	o	NN
cord-300872-blycbi4u	312	10	-	-	HYPH
cord-300872-blycbi4u	312	11	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	312	12	bond	bond	NN
cord-300872-blycbi4u	312	13	or	or	CC
cord-300872-blycbi4u	312	14	via	via	IN
cord-300872-blycbi4u	312	15	O	o	NN
cord-300872-blycbi4u	312	16	-	-	HYPH
cord-300872-blycbi4u	312	17	methylene	methylene	NN
cord-300872-blycbi4u	312	18	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	312	19	linker	linker	NN
cord-300872-blycbi4u	312	20	,	,	,
cord-300872-blycbi4u	312	21	as	as	IN
cord-300872-blycbi4u	312	22	shown	show	VBN
cord-300872-blycbi4u	312	23	in	in	IN
cord-300872-blycbi4u	312	24	Scheme	Scheme	NNP
cord-300872-blycbi4u	312	25	11	11	CD
cord-300872-blycbi4u	312	26	.	.	.
cord-300872-blycbi4u	313	1	Sugar	sugar	NN
cord-300872-blycbi4u	313	2	derivatives	derivative	NNS
cord-300872-blycbi4u	313	3	of	of	IN
cord-300872-blycbi4u	313	4	44	44	CD
cord-300872-blycbi4u	313	5	and	and	CC
cord-300872-blycbi4u	313	6	45	45	CD
cord-300872-blycbi4u	313	7	were	be	VBD
cord-300872-blycbi4u	313	8	prepared	prepare	VBN
cord-300872-blycbi4u	313	9	according	accord	VBG
cord-300872-blycbi4u	313	10	to	to	IN
cord-300872-blycbi4u	313	11	published	publish	VBN
cord-300872-blycbi4u	313	12	procedures	procedure	NNS
cord-300872-blycbi4u	313	13	[	[	-LRB-
cord-300872-blycbi4u	313	14	30	30	CD
cord-300872-blycbi4u	313	15	]	]	-RRB-
cord-300872-blycbi4u	314	1	[	[	-LRB-
cord-300872-blycbi4u	314	2	31	31	CD
cord-300872-blycbi4u	314	3	]	]	-RRB-
cord-300872-blycbi4u	314	4	[	[	-LRB-
cord-300872-blycbi4u	314	5	32	32	CD
cord-300872-blycbi4u	314	6	]	]	-RRB-
cord-300872-blycbi4u	314	7	;	;	:
cord-300872-blycbi4u	314	8	sugar	sugar	NN
cord-300872-blycbi4u	314	9	was	be	VBD
cord-300872-blycbi4u	314	10	used	use	VBN
cord-300872-blycbi4u	314	11	to	to	TO
cord-300872-blycbi4u	314	12	enhance	enhance	VB
cord-300872-blycbi4u	314	13	the	the	DT
cord-300872-blycbi4u	314	14	bioavailability	bioavailability	NN
cord-300872-blycbi4u	314	15	and	and	CC
cord-300872-blycbi4u	314	16	solubility	solubility	NN
cord-300872-blycbi4u	314	17	of	of	IN
cord-300872-blycbi4u	314	18	potential	potential	JJ
cord-300872-blycbi4u	314	19	drugs	drug	NNS
cord-300872-blycbi4u	314	20	.	.	.
cord-300872-blycbi4u	315	1	All	all	DT
cord-300872-blycbi4u	315	2	prepared	prepared	JJ
cord-300872-blycbi4u	315	3	derivatives	derivative	NNS
cord-300872-blycbi4u	315	4	were	be	VBD
cord-300872-blycbi4u	315	5	tested	test	VBN
cord-300872-blycbi4u	315	6	against	against	IN
cord-300872-blycbi4u	315	7	different	different	JJ
cord-300872-blycbi4u	315	8	cancer	cancer	NN
cord-300872-blycbi4u	315	9	cell	cell	NN
cord-300872-blycbi4u	315	10	lines	line	NNS
cord-300872-blycbi4u	315	11	,	,	,
cord-300872-blycbi4u	315	12	including	include	VBG
cord-300872-blycbi4u	315	13	Hela	Hela	NNP
cord-300872-blycbi4u	315	14	,	,	,
cord-300872-blycbi4u	315	15	HCT	HCT	NNP
cord-300872-blycbi4u	315	16	116	116	CD
cord-300872-blycbi4u	315	17	,	,	,
cord-300872-blycbi4u	315	18	and	and	CC
cord-300872-blycbi4u	315	19	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	315	20	,	,	,
cord-300872-blycbi4u	315	21	in	in	IN
cord-300872-blycbi4u	315	22	addition	addition	NN
cord-300872-blycbi4u	315	23	to	to	IN
cord-300872-blycbi4u	315	24	a	a	DT
cord-300872-blycbi4u	315	25	normal	normal	JJ
cord-300872-blycbi4u	315	26	human	human	JJ
cord-300872-blycbi4u	315	27	dermal	dermal	JJ
cord-300872-blycbi4u	315	28	neonatal	neonatal	JJ
cord-300872-blycbi4u	315	29	fibroblast	fibroblast	NN
cord-300872-blycbi4u	315	30	(	(	-LRB-
cord-300872-blycbi4u	315	31	NHDF	NHDF	NNP
cord-300872-blycbi4u	315	32	-	-	HYPH
cord-300872-blycbi4u	315	33	Neo	Neo	NNP
cord-300872-blycbi4u	315	34	)	)	-RRB-
cord-300872-blycbi4u	315	35	.	.	.
cord-300872-blycbi4u	316	1	Compound	compound	NN
cord-300872-blycbi4u	316	2	2	2	CD
cord-300872-blycbi4u	316	3	,	,	,
cord-300872-blycbi4u	316	4	designated	designate	VBN
cord-300872-blycbi4u	316	5	with	with	IN
cord-300872-blycbi4u	316	6	R	r	NN
cord-300872-blycbi4u	316	7	=	=	SYM
cord-300872-blycbi4u	316	8	R	r	NN
cord-300872-blycbi4u	316	9	1	1	CD
cord-300872-blycbi4u	316	10	=	=	SYM
cord-300872-blycbi4u	316	11	H	h	NN
cord-300872-blycbi4u	316	12	and	and	CC
cord-300872-blycbi4u	316	13	R	r	NN
cord-300872-blycbi4u	316	14	2	2	CD
cord-300872-blycbi4u	316	15	=	=	SYM
cord-300872-blycbi4u	316	16	OAc	OAc	NNS
cord-300872-blycbi4u	316	17	,	,	,
cord-300872-blycbi4u	316	18	was	be	VBD
cord-300872-blycbi4u	316	19	the	the	DT
cord-300872-blycbi4u	316	20	most	most	RBS
cord-300872-blycbi4u	316	21	active	active	JJ
cord-300872-blycbi4u	316	22	,	,	,
cord-300872-blycbi4u	316	23	with	with	IN
cord-300872-blycbi4u	316	24	IC	IC	NNP
cord-300872-blycbi4u	316	25	50	50	CD
cord-300872-blycbi4u	316	26	values	value	NNS
cord-300872-blycbi4u	316	27	of	of	IN
cord-300872-blycbi4u	316	28	30.98	30.98	CD
cord-300872-blycbi4u	316	29	,	,	,
cord-300872-blycbi4u	316	30	22.7	22.7	CD
cord-300872-blycbi4u	316	31	,	,	,
cord-300872-blycbi4u	316	32	and	and	CC
cord-300872-blycbi4u	316	33	4.12	4.12	CD
cord-300872-blycbi4u	316	34	mM	mm	CD
cord-300872-blycbi4u	316	35	against	against	IN
cord-300872-blycbi4u	316	36	Hela	Hela	NNP
cord-300872-blycbi4u	316	37	,	,	,
cord-300872-blycbi4u	316	38	HCT	HCT	NNP
cord-300872-blycbi4u	316	39	116	116	CD
cord-300872-blycbi4u	316	40	,	,	,
cord-300872-blycbi4u	316	41	and	and	CC
cord-300872-blycbi4u	316	42	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	316	43	,	,	,
cord-300872-blycbi4u	316	44	respectively	respectively	RB
cord-300872-blycbi4u	316	45	.	.	.
cord-300872-blycbi4u	317	1	Other	other	JJ
cord-300872-blycbi4u	317	2	derivatives	derivative	NNS
cord-300872-blycbi4u	317	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	317	4	low	low	JJ
cord-300872-blycbi4u	317	5	bioactivity	bioactivity	NN
cord-300872-blycbi4u	317	6	.	.	.
cord-300872-blycbi4u	318	1	This	this	DT
cord-300872-blycbi4u	318	2	could	could	MD
cord-300872-blycbi4u	318	3	be	be	VB
cord-300872-blycbi4u	318	4	attributed	attribute	VBN
cord-300872-blycbi4u	318	5	to	to	IN
cord-300872-blycbi4u	318	6	the	the	DT
cord-300872-blycbi4u	318	7	use	use	NN
cord-300872-blycbi4u	318	8	of	of	IN
cord-300872-blycbi4u	318	9	the	the	DT
cord-300872-blycbi4u	318	10	quinolone	quinolone	NNP
cord-300872-blycbi4u	318	11	hydroxyl	hydroxyl	NNP
cord-300872-blycbi4u	318	12	group	group	NN
cord-300872-blycbi4u	318	13	to	to	TO
cord-300872-blycbi4u	318	14	form	form	VB
cord-300872-blycbi4u	318	15	a	a	DT
cord-300872-blycbi4u	318	16	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	318	17	linkage	linkage	NN
cord-300872-blycbi4u	318	18	,	,	,
cord-300872-blycbi4u	318	19	which	which	WDT
cord-300872-blycbi4u	318	20	impedes	impede	VBZ
cord-300872-blycbi4u	318	21	the	the	DT
cord-300872-blycbi4u	318	22	chelation	chelation	NN
cord-300872-blycbi4u	318	23	of	of	IN
cord-300872-blycbi4u	318	24	metal	metal	NN
cord-300872-blycbi4u	318	25	ions	ion	NNS
cord-300872-blycbi4u	318	26	due	due	JJ
cord-300872-blycbi4u	318	27	to	to	IN
cord-300872-blycbi4u	318	28	steric	steric	JJ
cord-300872-blycbi4u	318	29	hindrance	hindrance	NN
cord-300872-blycbi4u	318	30	.	.	.
cord-300872-blycbi4u	319	1	In	in	IN
cord-300872-blycbi4u	319	2	this	this	DT
cord-300872-blycbi4u	319	3	respect	respect	NN
cord-300872-blycbi4u	319	4	,	,	,
cord-300872-blycbi4u	319	5	it	-PRON-	PRP
cord-300872-blycbi4u	319	6	should	should	MD
cord-300872-blycbi4u	319	7	be	be	VB
cord-300872-blycbi4u	319	8	stated	state	VBN
cord-300872-blycbi4u	319	9	that	that	IN
cord-300872-blycbi4u	319	10	the	the	DT
cord-300872-blycbi4u	319	11	presence	presence	NN
cord-300872-blycbi4u	319	12	of	of	IN
cord-300872-blycbi4u	319	13	the	the	DT
cord-300872-blycbi4u	319	14	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	319	15	moiety	moiety	NN
cord-300872-blycbi4u	319	16	improves	improve	VBZ
cord-300872-blycbi4u	319	17	the	the	DT
cord-300872-blycbi4u	319	18	activity	activity	NN
cord-300872-blycbi4u	319	19	of	of	IN
cord-300872-blycbi4u	319	20	glycoconjugates	glycoconjugate	NNS
cord-300872-blycbi4u	319	21	,	,	,
cord-300872-blycbi4u	319	22	whereas	whereas	IN
cord-300872-blycbi4u	319	23	the	the	DT
cord-300872-blycbi4u	319	24	type	type	NN
cord-300872-blycbi4u	319	25	of	of	IN
cord-300872-blycbi4u	319	26	sugar	sugar	NN
cord-300872-blycbi4u	319	27	fragment	fragment	NN
cord-300872-blycbi4u	319	28	did	do	VBD
cord-300872-blycbi4u	319	29	not	not	RB
cord-300872-blycbi4u	319	30	affect	affect	VB
cord-300872-blycbi4u	319	31	the	the	DT
cord-300872-blycbi4u	319	32	activity	activity	NN
cord-300872-blycbi4u	319	33	significantly	significantly	RB
cord-300872-blycbi4u	319	34	.	.	.
cord-300872-blycbi4u	320	1	Finally	finally	RB
cord-300872-blycbi4u	320	2	,	,	,
cord-300872-blycbi4u	320	3	conjugates	conjugate	NNS
cord-300872-blycbi4u	320	4	with	with	IN
cord-300872-blycbi4u	320	5	a	a	DT
cord-300872-blycbi4u	320	6	sugar	sugar	NN
cord-300872-blycbi4u	320	7	moiety	moiety	NN
cord-300872-blycbi4u	320	8	and	and	CC
cord-300872-blycbi4u	320	9	free	free	JJ
cord-300872-blycbi4u	320	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	320	11	group	group	NN
cord-300872-blycbi4u	320	12	exerted	exert	VBD
cord-300872-blycbi4u	320	13	better	well	JJR
cord-300872-blycbi4u	320	14	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	320	15	potential	potential	NN
cord-300872-blycbi4u	320	16	than	than	IN
cord-300872-blycbi4u	320	17	acetylated	acetylated	JJ
cord-300872-blycbi4u	320	18	analogs	analog	NNS
cord-300872-blycbi4u	320	19	.	.	.
cord-300872-blycbi4u	321	1	All	all	DT
cord-300872-blycbi4u	321	2	prepared	prepared	JJ
cord-300872-blycbi4u	321	3	derivatives	derivative	NNS
cord-300872-blycbi4u	321	4	were	be	VBD
cord-300872-blycbi4u	321	5	tested	test	VBN
cord-300872-blycbi4u	321	6	against	against	IN
cord-300872-blycbi4u	321	7	different	different	JJ
cord-300872-blycbi4u	321	8	cancer	cancer	NN
cord-300872-blycbi4u	321	9	cell	cell	NN
cord-300872-blycbi4u	321	10	lines	line	NNS
cord-300872-blycbi4u	321	11	,	,	,
cord-300872-blycbi4u	321	12	including	include	VBG
cord-300872-blycbi4u	321	13	Hela	Hela	NNP
cord-300872-blycbi4u	321	14	,	,	,
cord-300872-blycbi4u	321	15	HCT	HCT	NNP
cord-300872-blycbi4u	321	16	116	116	CD
cord-300872-blycbi4u	321	17	,	,	,
cord-300872-blycbi4u	321	18	and	and	CC
cord-300872-blycbi4u	321	19	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	321	20	,	,	,
cord-300872-blycbi4u	321	21	in	in	IN
cord-300872-blycbi4u	321	22	addition	addition	NN
cord-300872-blycbi4u	321	23	to	to	IN
cord-300872-blycbi4u	321	24	a	a	DT
cord-300872-blycbi4u	321	25	normal	normal	JJ
cord-300872-blycbi4u	321	26	human	human	JJ
cord-300872-blycbi4u	321	27	dermal	dermal	JJ
cord-300872-blycbi4u	321	28	neonatal	neonatal	JJ
cord-300872-blycbi4u	321	29	fibroblast	fibroblast	NN
cord-300872-blycbi4u	321	30	(	(	-LRB-
cord-300872-blycbi4u	321	31	NHDF	NHDF	NNP
cord-300872-blycbi4u	321	32	-	-	HYPH
cord-300872-blycbi4u	321	33	Neo	Neo	NNP
cord-300872-blycbi4u	321	34	)	)	-RRB-
cord-300872-blycbi4u	321	35	.	.	.
cord-300872-blycbi4u	322	1	Compound	compound	NN
cord-300872-blycbi4u	322	2	2	2	CD
cord-300872-blycbi4u	322	3	,	,	,
cord-300872-blycbi4u	322	4	designated	designate	VBN
cord-300872-blycbi4u	322	5	with	with	IN
cord-300872-blycbi4u	322	6	R	r	NN
cord-300872-blycbi4u	322	7	=	=	SYM
cord-300872-blycbi4u	322	8	R1	r1	NN
cord-300872-blycbi4u	322	9	=	=	SYM
cord-300872-blycbi4u	322	10	H	h	NN
cord-300872-blycbi4u	322	11	and	and	CC
cord-300872-blycbi4u	322	12	R2	r2	NN
cord-300872-blycbi4u	322	13	=	=	SYM
cord-300872-blycbi4u	322	14	OAc	OAc	NNS
cord-300872-blycbi4u	322	15	,	,	,
cord-300872-blycbi4u	322	16	was	be	VBD
cord-300872-blycbi4u	322	17	the	the	DT
cord-300872-blycbi4u	322	18	most	most	RBS
cord-300872-blycbi4u	322	19	active	active	JJ
cord-300872-blycbi4u	322	20	,	,	,
cord-300872-blycbi4u	322	21	with	with	IN
cord-300872-blycbi4u	322	22	IC50	ic50	JJ
cord-300872-blycbi4u	322	23	values	value	NNS
cord-300872-blycbi4u	322	24	of	of	IN
cord-300872-blycbi4u	322	25	30.98	30.98	CD
cord-300872-blycbi4u	322	26	,	,	,
cord-300872-blycbi4u	322	27	22.7	22.7	CD
cord-300872-blycbi4u	322	28	,	,	,
cord-300872-blycbi4u	322	29	and	and	CC
cord-300872-blycbi4u	322	30	4.12	4.12	CD
cord-300872-blycbi4u	322	31	mM	mm	CD
cord-300872-blycbi4u	322	32	against	against	IN
cord-300872-blycbi4u	322	33	Hela	Hela	NNP
cord-300872-blycbi4u	322	34	,	,	,
cord-300872-blycbi4u	322	35	HCT	HCT	NNP
cord-300872-blycbi4u	322	36	116	116	CD
cord-300872-blycbi4u	322	37	,	,	,
cord-300872-blycbi4u	322	38	and	and	CC
cord-300872-blycbi4u	322	39	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	322	40	,	,	,
cord-300872-blycbi4u	322	41	respectively	respectively	RB
cord-300872-blycbi4u	322	42	.	.	.
cord-300872-blycbi4u	323	1	Other	other	JJ
cord-300872-blycbi4u	323	2	derivatives	derivative	NNS
cord-300872-blycbi4u	323	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	323	4	low	low	JJ
cord-300872-blycbi4u	323	5	bioactivity	bioactivity	NN
cord-300872-blycbi4u	323	6	.	.	.
cord-300872-blycbi4u	324	1	This	this	DT
cord-300872-blycbi4u	324	2	could	could	MD
cord-300872-blycbi4u	324	3	be	be	VB
cord-300872-blycbi4u	324	4	attributed	attribute	VBN
cord-300872-blycbi4u	324	5	to	to	IN
cord-300872-blycbi4u	324	6	the	the	DT
cord-300872-blycbi4u	324	7	use	use	NN
cord-300872-blycbi4u	324	8	of	of	IN
cord-300872-blycbi4u	324	9	the	the	DT
cord-300872-blycbi4u	324	10	quinolone	quinolone	NNP
cord-300872-blycbi4u	324	11	hydroxyl	hydroxyl	NNP
cord-300872-blycbi4u	324	12	group	group	NN
cord-300872-blycbi4u	324	13	to	to	TO
cord-300872-blycbi4u	324	14	form	form	VB
cord-300872-blycbi4u	324	15	a	a	DT
cord-300872-blycbi4u	324	16	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	324	17	linkage	linkage	NN
cord-300872-blycbi4u	324	18	,	,	,
cord-300872-blycbi4u	324	19	which	which	WDT
cord-300872-blycbi4u	324	20	impedes	impede	VBZ
cord-300872-blycbi4u	324	21	the	the	DT
cord-300872-blycbi4u	324	22	chelation	chelation	NN
cord-300872-blycbi4u	324	23	of	of	IN
cord-300872-blycbi4u	324	24	metal	metal	NN
cord-300872-blycbi4u	324	25	ions	ion	NNS
cord-300872-blycbi4u	324	26	due	due	JJ
cord-300872-blycbi4u	324	27	to	to	IN
cord-300872-blycbi4u	324	28	steric	steric	JJ
cord-300872-blycbi4u	324	29	hindrance	hindrance	NN
cord-300872-blycbi4u	324	30	.	.	.
cord-300872-blycbi4u	325	1	In	in	IN
cord-300872-blycbi4u	325	2	this	this	DT
cord-300872-blycbi4u	325	3	respect	respect	NN
cord-300872-blycbi4u	325	4	,	,	,
cord-300872-blycbi4u	325	5	it	-PRON-	PRP
cord-300872-blycbi4u	325	6	should	should	MD
cord-300872-blycbi4u	325	7	be	be	VB
cord-300872-blycbi4u	325	8	stated	state	VBN
cord-300872-blycbi4u	325	9	that	that	IN
cord-300872-blycbi4u	325	10	the	the	DT
cord-300872-blycbi4u	325	11	presence	presence	NN
cord-300872-blycbi4u	325	12	of	of	IN
cord-300872-blycbi4u	325	13	the	the	DT
cord-300872-blycbi4u	325	14	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	325	15	moiety	moiety	NN
cord-300872-blycbi4u	325	16	improves	improve	VBZ
cord-300872-blycbi4u	325	17	the	the	DT
cord-300872-blycbi4u	325	18	activity	activity	NN
cord-300872-blycbi4u	325	19	of	of	IN
cord-300872-blycbi4u	325	20	glycoconjugates	glycoconjugate	NNS
cord-300872-blycbi4u	325	21	,	,	,
cord-300872-blycbi4u	325	22	whereas	whereas	IN
cord-300872-blycbi4u	325	23	the	the	DT
cord-300872-blycbi4u	325	24	type	type	NN
cord-300872-blycbi4u	325	25	of	of	IN
cord-300872-blycbi4u	325	26	sugar	sugar	NN
cord-300872-blycbi4u	325	27	fragment	fragment	NN
cord-300872-blycbi4u	325	28	did	do	VBD
cord-300872-blycbi4u	325	29	not	not	RB
cord-300872-blycbi4u	325	30	affect	affect	VB
cord-300872-blycbi4u	325	31	the	the	DT
cord-300872-blycbi4u	325	32	activity	activity	NN
cord-300872-blycbi4u	325	33	significantly	significantly	RB
cord-300872-blycbi4u	325	34	.	.	.
cord-300872-blycbi4u	326	1	Finally	finally	RB
cord-300872-blycbi4u	326	2	,	,	,
cord-300872-blycbi4u	326	3	conjugates	conjugate	NNS
cord-300872-blycbi4u	326	4	with	with	IN
cord-300872-blycbi4u	326	5	a	a	DT
cord-300872-blycbi4u	326	6	sugar	sugar	NN
cord-300872-blycbi4u	326	7	moiety	moiety	NN
cord-300872-blycbi4u	326	8	and	and	CC
cord-300872-blycbi4u	326	9	free	free	JJ
cord-300872-blycbi4u	326	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	326	11	group	group	NN
cord-300872-blycbi4u	326	12	exerted	exert	VBD
cord-300872-blycbi4u	326	13	better	well	JJR
cord-300872-blycbi4u	326	14	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	326	15	potential	potential	NN
cord-300872-blycbi4u	326	16	than	than	IN
cord-300872-blycbi4u	326	17	acetylated	acetylated	JJ
cord-300872-blycbi4u	326	18	analogs	analog	NNS
cord-300872-blycbi4u	326	19	.	.	.
cord-300872-blycbi4u	327	1	Fouda	Fouda	NNP
cord-300872-blycbi4u	327	2	published	publish	VBD
cord-300872-blycbi4u	327	3	a	a	DT
cord-300872-blycbi4u	327	4	paper	paper	NN
cord-300872-blycbi4u	327	5	dealing	deal	VBG
cord-300872-blycbi4u	327	6	with	with	IN
cord-300872-blycbi4u	327	7	the	the	DT
cord-300872-blycbi4u	327	8	synthesis	synthesis	NN
cord-300872-blycbi4u	327	9	,	,	,
cord-300872-blycbi4u	327	10	characterization	characterization	NN
cord-300872-blycbi4u	327	11	,	,	,
cord-300872-blycbi4u	327	12	and	and	CC
cord-300872-blycbi4u	327	13	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	327	14	of	of	IN
cord-300872-blycbi4u	327	15	new	new	JJ
cord-300872-blycbi4u	327	16	derivatives	derivative	NNS
cord-300872-blycbi4u	327	17	of	of	IN
cord-300872-blycbi4u	327	18	halogenated	halogenated	JJ
cord-300872-blycbi4u	327	19	2-amino-4-aryl-4-pyrano[3,2-h]quinolone-3-carbonitrile	2-amino-4-aryl-4-pyrano[3,2-h]quinolone-3-carbonitrile	CD
cord-300872-blycbi4u	327	20	(	(	-LRB-
cord-300872-blycbi4u	327	21	48	48	CD
cord-300872-blycbi4u	327	22	)	)	-RRB-
cord-300872-blycbi4u	327	23	derivatives	derivative	NNS
cord-300872-blycbi4u	327	24	(	(	-LRB-
cord-300872-blycbi4u	327	25	Scheme	scheme	NN
cord-300872-blycbi4u	327	26	12	12	CD
cord-300872-blycbi4u	327	27	)	)	-RRB-
cord-300872-blycbi4u	327	28	[	[	-LRB-
cord-300872-blycbi4u	327	29	33	33	CD
cord-300872-blycbi4u	327	30	]	]	-RRB-
cord-300872-blycbi4u	327	31	.	.	.
cord-300872-blycbi4u	328	1	These	these	DT
cord-300872-blycbi4u	328	2	derivatives	derivative	NNS
cord-300872-blycbi4u	328	3	were	be	VBD
cord-300872-blycbi4u	328	4	prepared	prepare	VBN
cord-300872-blycbi4u	328	5	through	through	IN
cord-300872-blycbi4u	328	6	interactions	interaction	NNS
cord-300872-blycbi4u	328	7	of	of	IN
cord-300872-blycbi4u	328	8	various	various	JJ
cord-300872-blycbi4u	328	9	8hydroxyquinolines	8hydroxyquinolines	CD
cord-300872-blycbi4u	328	10	(	(	-LRB-
cord-300872-blycbi4u	328	11	46	46	CD
cord-300872-blycbi4u	328	12	)	)	-RRB-
cord-300872-blycbi4u	328	13	with	with	IN
cord-300872-blycbi4u	328	14	α	α	NN
cord-300872-blycbi4u	328	15	-	-	HYPH
cord-300872-blycbi4u	328	16	cyanocinnamonitriles	cyanocinnamonitrile	NNS
cord-300872-blycbi4u	328	17	(	(	-LRB-
cord-300872-blycbi4u	328	18	47	47	CD
cord-300872-blycbi4u	328	19	)	)	-RRB-
cord-300872-blycbi4u	328	20	.	.	.
cord-300872-blycbi4u	329	1	These	these	DT
cord-300872-blycbi4u	329	2	prepared	prepared	JJ
cord-300872-blycbi4u	329	3	compounds	compound	NNS
cord-300872-blycbi4u	329	4	were	be	VBD
cord-300872-blycbi4u	329	5	screened	screen	VBN
cord-300872-blycbi4u	329	6	for	for	IN
cord-300872-blycbi4u	329	7	potential	potential	JJ
cord-300872-blycbi4u	329	8	anticancer	anticancer	JJ
cord-300872-blycbi4u	329	9	activity	activity	NN
cord-300872-blycbi4u	329	10	against	against	IN
cord-300872-blycbi4u	329	11	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	329	12	,	,	,
cord-300872-blycbi4u	329	13	HCT	HCT	NNP
cord-300872-blycbi4u	329	14	116	116	CD
cord-300872-blycbi4u	329	15	,	,	,
cord-300872-blycbi4u	329	16	HepG-2	hepg-2	CD
cord-300872-blycbi4u	329	17	,	,	,
cord-300872-blycbi4u	329	18	and	and	CC
cord-300872-blycbi4u	329	19	A549	A549	NNPS
cord-300872-blycbi4u	329	20	using	use	VBG
cord-300872-blycbi4u	329	21	the	the	DT
cord-300872-blycbi4u	329	22	MMT	MMT	NNP
cord-300872-blycbi4u	329	23	assay	assay	NN
cord-300872-blycbi4u	329	24	.	.	.
cord-300872-blycbi4u	330	1	Structure	structure	NN
cord-300872-blycbi4u	330	2	-	-	HYPH
cord-300872-blycbi4u	330	3	activity	activity	NN
cord-300872-blycbi4u	330	4	relationship	relationship	NN
cord-300872-blycbi4u	330	5	(	(	-LRB-
cord-300872-blycbi4u	330	6	SAR	SAR	NNP
cord-300872-blycbi4u	330	7	)	)	-RRB-
cord-300872-blycbi4u	330	8	results	result	NNS
cord-300872-blycbi4u	330	9	revealed	reveal	VBD
cord-300872-blycbi4u	330	10	that	that	IN
cord-300872-blycbi4u	330	11	6-chloroanalogues	6-chloroanalogues	CD
cord-300872-blycbi4u	330	12	were	be	VBD
cord-300872-blycbi4u	330	13	the	the	DT
cord-300872-blycbi4u	330	14	most	most	RBS
cord-300872-blycbi4u	330	15	active	active	JJ
cord-300872-blycbi4u	330	16	,	,	,
cord-300872-blycbi4u	330	17	whereas	whereas	IN
cord-300872-blycbi4u	330	18	the	the	DT
cord-300872-blycbi4u	330	19	9-methylanaloguess	9-methylanaloguess	CD
cord-300872-blycbi4u	330	20	were	be	VBD
cord-300872-blycbi4u	330	21	the	the	DT
cord-300872-blycbi4u	330	22	least	least	JJS
cord-300872-blycbi4u	330	23	potent	potent	JJ
cord-300872-blycbi4u	330	24	.	.	.
cord-300872-blycbi4u	331	1	In	in	IN
cord-300872-blycbi4u	331	2	addition	addition	NN
cord-300872-blycbi4u	331	3	,	,	,
cord-300872-blycbi4u	331	4	the	the	DT
cord-300872-blycbi4u	331	5	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	331	6	of	of	IN
cord-300872-blycbi4u	331	7	the	the	DT
cord-300872-blycbi4u	331	8	products	product	NNS
cord-300872-blycbi4u	331	9	increased	increase	VBD
cord-300872-blycbi4u	331	10	in	in	IN
cord-300872-blycbi4u	331	11	the	the	DT
cord-300872-blycbi4u	331	12	presence	presence	NN
cord-300872-blycbi4u	331	13	of	of	IN
cord-300872-blycbi4u	331	14	halogen	halogen	NNP
cord-300872-blycbi4u	331	15	atom	atom	NN
cord-300872-blycbi4u	331	16	substituents	substituent	NNS
cord-300872-blycbi4u	331	17	at	at	IN
cord-300872-blycbi4u	331	18	positions	position	NNS
cord-300872-blycbi4u	331	19	4	4	CD
cord-300872-blycbi4u	331	20	,	,	,
cord-300872-blycbi4u	331	21	6	6	CD
cord-300872-blycbi4u	331	22	,	,	,
cord-300872-blycbi4u	331	23	and	and	CC
cord-300872-blycbi4u	331	24	9	9	CD
cord-300872-blycbi4u	331	25	.	.	.
cord-300872-blycbi4u	332	1	The	the	DT
cord-300872-blycbi4u	332	2	IC50	IC50	NNP
cord-300872-blycbi4u	332	3	values	value	NNS
cord-300872-blycbi4u	332	4	(	(	-LRB-
cord-300872-blycbi4u	332	5	mg	mg	NN
cord-300872-blycbi4u	332	6	/	/	SYM
cord-300872-blycbi4u	332	7	mL	mL	NNP
cord-300872-blycbi4u	332	8	)	)	-RRB-
cord-300872-blycbi4u	332	9	of	of	IN
cord-300872-blycbi4u	332	10	these	these	DT
cord-300872-blycbi4u	332	11	compounds	compound	NNS
cord-300872-blycbi4u	332	12	were	be	VBD
cord-300872-blycbi4u	332	13	in	in	IN
cord-300872-blycbi4u	332	14	the	the	DT
cord-300872-blycbi4u	332	15	ranges	range	NNS
cord-300872-blycbi4u	332	16	of	of	IN
cord-300872-blycbi4u	332	17	0.9	0.9	CD
cord-300872-blycbi4u	332	18	-	-	SYM
cord-300872-blycbi4u	332	19	38	38	CD
cord-300872-blycbi4u	332	20	.	.	.
cord-300872-blycbi4u	333	1	All	all	DT
cord-300872-blycbi4u	333	2	prepared	prepared	JJ
cord-300872-blycbi4u	333	3	derivatives	derivative	NNS
cord-300872-blycbi4u	333	4	were	be	VBD
cord-300872-blycbi4u	333	5	tested	test	VBN
cord-300872-blycbi4u	333	6	against	against	IN
cord-300872-blycbi4u	333	7	different	different	JJ
cord-300872-blycbi4u	333	8	cancer	cancer	NN
cord-300872-blycbi4u	333	9	cell	cell	NN
cord-300872-blycbi4u	333	10	lines	line	NNS
cord-300872-blycbi4u	333	11	,	,	,
cord-300872-blycbi4u	333	12	including	include	VBG
cord-300872-blycbi4u	333	13	Hela	Hela	NNP
cord-300872-blycbi4u	333	14	,	,	,
cord-300872-blycbi4u	333	15	HCT	HCT	NNP
cord-300872-blycbi4u	333	16	116	116	CD
cord-300872-blycbi4u	333	17	,	,	,
cord-300872-blycbi4u	333	18	and	and	CC
cord-300872-blycbi4u	333	19	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	333	20	,	,	,
cord-300872-blycbi4u	333	21	in	in	IN
cord-300872-blycbi4u	333	22	addition	addition	NN
cord-300872-blycbi4u	333	23	to	to	IN
cord-300872-blycbi4u	333	24	a	a	DT
cord-300872-blycbi4u	333	25	normal	normal	JJ
cord-300872-blycbi4u	333	26	human	human	JJ
cord-300872-blycbi4u	333	27	dermal	dermal	JJ
cord-300872-blycbi4u	333	28	neonatal	neonatal	JJ
cord-300872-blycbi4u	333	29	fibroblast	fibroblast	NN
cord-300872-blycbi4u	333	30	(	(	-LRB-
cord-300872-blycbi4u	333	31	NHDF	NHDF	NNP
cord-300872-blycbi4u	333	32	-	-	HYPH
cord-300872-blycbi4u	333	33	Neo	Neo	NNP
cord-300872-blycbi4u	333	34	)	)	-RRB-
cord-300872-blycbi4u	333	35	.	.	.
cord-300872-blycbi4u	334	1	Compound	compound	NN
cord-300872-blycbi4u	334	2	2	2	CD
cord-300872-blycbi4u	334	3	,	,	,
cord-300872-blycbi4u	334	4	designated	designate	VBN
cord-300872-blycbi4u	334	5	with	with	IN
cord-300872-blycbi4u	334	6	R	r	NN
cord-300872-blycbi4u	334	7	=	=	SYM
cord-300872-blycbi4u	334	8	R1	r1	NN
cord-300872-blycbi4u	334	9	=	=	SYM
cord-300872-blycbi4u	334	10	H	h	NN
cord-300872-blycbi4u	334	11	and	and	CC
cord-300872-blycbi4u	334	12	R2	r2	NN
cord-300872-blycbi4u	334	13	=	=	SYM
cord-300872-blycbi4u	334	14	OAc	OAc	NNS
cord-300872-blycbi4u	334	15	,	,	,
cord-300872-blycbi4u	334	16	was	be	VBD
cord-300872-blycbi4u	334	17	the	the	DT
cord-300872-blycbi4u	334	18	most	most	RBS
cord-300872-blycbi4u	334	19	active	active	JJ
cord-300872-blycbi4u	334	20	,	,	,
cord-300872-blycbi4u	334	21	with	with	IN
cord-300872-blycbi4u	334	22	IC50	ic50	JJ
cord-300872-blycbi4u	334	23	values	value	NNS
cord-300872-blycbi4u	334	24	of	of	IN
cord-300872-blycbi4u	334	25	30.98	30.98	CD
cord-300872-blycbi4u	334	26	,	,	,
cord-300872-blycbi4u	334	27	22.7	22.7	CD
cord-300872-blycbi4u	334	28	,	,	,
cord-300872-blycbi4u	334	29	and	and	CC
cord-300872-blycbi4u	334	30	4.12	4.12	CD
cord-300872-blycbi4u	334	31	mM	mm	CD
cord-300872-blycbi4u	334	32	against	against	IN
cord-300872-blycbi4u	334	33	Hela	Hela	NNP
cord-300872-blycbi4u	334	34	,	,	,
cord-300872-blycbi4u	334	35	HCT	HCT	NNP
cord-300872-blycbi4u	334	36	116	116	CD
cord-300872-blycbi4u	334	37	,	,	,
cord-300872-blycbi4u	334	38	and	and	CC
cord-300872-blycbi4u	334	39	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	334	40	,	,	,
cord-300872-blycbi4u	334	41	respectively	respectively	RB
cord-300872-blycbi4u	334	42	.	.	.
cord-300872-blycbi4u	335	1	Other	other	JJ
cord-300872-blycbi4u	335	2	derivatives	derivative	NNS
cord-300872-blycbi4u	335	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	335	4	low	low	JJ
cord-300872-blycbi4u	335	5	bioactivity	bioactivity	NN
cord-300872-blycbi4u	335	6	.	.	.
cord-300872-blycbi4u	336	1	This	this	DT
cord-300872-blycbi4u	336	2	could	could	MD
cord-300872-blycbi4u	336	3	be	be	VB
cord-300872-blycbi4u	336	4	attributed	attribute	VBN
cord-300872-blycbi4u	336	5	to	to	IN
cord-300872-blycbi4u	336	6	the	the	DT
cord-300872-blycbi4u	336	7	use	use	NN
cord-300872-blycbi4u	336	8	of	of	IN
cord-300872-blycbi4u	336	9	the	the	DT
cord-300872-blycbi4u	336	10	quinolone	quinolone	NNP
cord-300872-blycbi4u	336	11	hydroxyl	hydroxyl	NNP
cord-300872-blycbi4u	336	12	group	group	NN
cord-300872-blycbi4u	336	13	to	to	TO
cord-300872-blycbi4u	336	14	form	form	VB
cord-300872-blycbi4u	336	15	a	a	DT
cord-300872-blycbi4u	336	16	glycosidic	glycosidic	JJ
cord-300872-blycbi4u	336	17	linkage	linkage	NN
cord-300872-blycbi4u	336	18	,	,	,
cord-300872-blycbi4u	336	19	which	which	WDT
cord-300872-blycbi4u	336	20	impedes	impede	VBZ
cord-300872-blycbi4u	336	21	the	the	DT
cord-300872-blycbi4u	336	22	chelation	chelation	NN
cord-300872-blycbi4u	336	23	of	of	IN
cord-300872-blycbi4u	336	24	metal	metal	NN
cord-300872-blycbi4u	336	25	ions	ion	NNS
cord-300872-blycbi4u	336	26	due	due	JJ
cord-300872-blycbi4u	336	27	to	to	IN
cord-300872-blycbi4u	336	28	steric	steric	JJ
cord-300872-blycbi4u	336	29	hindrance	hindrance	NN
cord-300872-blycbi4u	336	30	.	.	.
cord-300872-blycbi4u	337	1	In	in	IN
cord-300872-blycbi4u	337	2	this	this	DT
cord-300872-blycbi4u	337	3	respect	respect	NN
cord-300872-blycbi4u	337	4	,	,	,
cord-300872-blycbi4u	337	5	it	-PRON-	PRP
cord-300872-blycbi4u	337	6	should	should	MD
cord-300872-blycbi4u	337	7	be	be	VB
cord-300872-blycbi4u	337	8	stated	state	VBN
cord-300872-blycbi4u	337	9	that	that	IN
cord-300872-blycbi4u	337	10	the	the	DT
cord-300872-blycbi4u	337	11	presence	presence	NN
cord-300872-blycbi4u	337	12	of	of	IN
cord-300872-blycbi4u	337	13	the	the	DT
cord-300872-blycbi4u	337	14	1,2,3-triazole	1,2,3-triazole	CD
cord-300872-blycbi4u	337	15	moiety	moiety	NN
cord-300872-blycbi4u	337	16	improves	improve	VBZ
cord-300872-blycbi4u	337	17	the	the	DT
cord-300872-blycbi4u	337	18	activity	activity	NN
cord-300872-blycbi4u	337	19	of	of	IN
cord-300872-blycbi4u	337	20	glycoconjugates	glycoconjugate	NNS
cord-300872-blycbi4u	337	21	,	,	,
cord-300872-blycbi4u	337	22	whereas	whereas	IN
cord-300872-blycbi4u	337	23	the	the	DT
cord-300872-blycbi4u	337	24	type	type	NN
cord-300872-blycbi4u	337	25	of	of	IN
cord-300872-blycbi4u	337	26	sugar	sugar	NN
cord-300872-blycbi4u	337	27	fragment	fragment	NN
cord-300872-blycbi4u	337	28	did	do	VBD
cord-300872-blycbi4u	337	29	not	not	RB
cord-300872-blycbi4u	337	30	affect	affect	VB
cord-300872-blycbi4u	337	31	the	the	DT
cord-300872-blycbi4u	337	32	activity	activity	NN
cord-300872-blycbi4u	337	33	significantly	significantly	RB
cord-300872-blycbi4u	337	34	.	.	.
cord-300872-blycbi4u	338	1	Finally	finally	RB
cord-300872-blycbi4u	338	2	,	,	,
cord-300872-blycbi4u	338	3	conjugates	conjugate	NNS
cord-300872-blycbi4u	338	4	with	with	IN
cord-300872-blycbi4u	338	5	a	a	DT
cord-300872-blycbi4u	338	6	sugar	sugar	NN
cord-300872-blycbi4u	338	7	moiety	moiety	NN
cord-300872-blycbi4u	338	8	and	and	CC
cord-300872-blycbi4u	338	9	free	free	JJ
cord-300872-blycbi4u	338	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	338	11	group	group	NN
cord-300872-blycbi4u	338	12	exerted	exert	VBD
cord-300872-blycbi4u	338	13	better	well	JJR
cord-300872-blycbi4u	338	14	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	338	15	potential	potential	NN
cord-300872-blycbi4u	338	16	than	than	IN
cord-300872-blycbi4u	338	17	acetylated	acetylated	JJ
cord-300872-blycbi4u	338	18	analogs	analog	NNS
cord-300872-blycbi4u	338	19	.	.	.
cord-300872-blycbi4u	339	1	Fouda	Fouda	NNP
cord-300872-blycbi4u	339	2	published	publish	VBD
cord-300872-blycbi4u	339	3	a	a	DT
cord-300872-blycbi4u	339	4	paper	paper	NN
cord-300872-blycbi4u	339	5	dealing	deal	VBG
cord-300872-blycbi4u	339	6	with	with	IN
cord-300872-blycbi4u	339	7	the	the	DT
cord-300872-blycbi4u	339	8	synthesis	synthesis	NN
cord-300872-blycbi4u	339	9	,	,	,
cord-300872-blycbi4u	339	10	characterization	characterization	NN
cord-300872-blycbi4u	339	11	,	,	,
cord-300872-blycbi4u	339	12	and	and	CC
cord-300872-blycbi4u	339	13	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	339	14	of	of	IN
cord-300872-blycbi4u	339	15	new	new	JJ
cord-300872-blycbi4u	339	16	derivatives	derivative	NNS
cord-300872-blycbi4u	339	17	of	of	IN
cord-300872-blycbi4u	339	18	halogenated	halogenated	JJ
cord-300872-blycbi4u	339	19	2-amino-4-aryl-4-pyrano[3,2-h]quinolone-3-carbonitrile	2-amino-4-aryl-4-pyrano[3,2-h]quinolone-3-carbonitrile	CD
cord-300872-blycbi4u	339	20	(	(	-LRB-
cord-300872-blycbi4u	339	21	48	48	CD
cord-300872-blycbi4u	339	22	)	)	-RRB-
cord-300872-blycbi4u	339	23	derivatives	derivative	NNS
cord-300872-blycbi4u	339	24	(	(	-LRB-
cord-300872-blycbi4u	339	25	Scheme	scheme	NN
cord-300872-blycbi4u	339	26	12	12	CD
cord-300872-blycbi4u	339	27	)	)	-RRB-
cord-300872-blycbi4u	339	28	[	[	-LRB-
cord-300872-blycbi4u	339	29	33	33	CD
cord-300872-blycbi4u	339	30	]	]	-RRB-
cord-300872-blycbi4u	339	31	.	.	.
cord-300872-blycbi4u	340	1	These	these	DT
cord-300872-blycbi4u	340	2	derivatives	derivative	NNS
cord-300872-blycbi4u	340	3	were	be	VBD
cord-300872-blycbi4u	340	4	prepared	prepare	VBN
cord-300872-blycbi4u	340	5	through	through	IN
cord-300872-blycbi4u	340	6	interactions	interaction	NNS
cord-300872-blycbi4u	340	7	of	of	IN
cord-300872-blycbi4u	340	8	various	various	JJ
cord-300872-blycbi4u	340	9	8hydroxyquinolines	8hydroxyquinolines	CD
cord-300872-blycbi4u	340	10	(	(	-LRB-
cord-300872-blycbi4u	340	11	46	46	CD
cord-300872-blycbi4u	340	12	)	)	-RRB-
cord-300872-blycbi4u	340	13	with	with	IN
cord-300872-blycbi4u	340	14	α	α	NN
cord-300872-blycbi4u	340	15	-	-	HYPH
cord-300872-blycbi4u	340	16	cyanocinnamonitriles	cyanocinnamonitrile	NNS
cord-300872-blycbi4u	340	17	(	(	-LRB-
cord-300872-blycbi4u	340	18	47	47	CD
cord-300872-blycbi4u	340	19	)	)	-RRB-
cord-300872-blycbi4u	340	20	.	.	.
cord-300872-blycbi4u	341	1	These	these	DT
cord-300872-blycbi4u	341	2	prepared	prepared	JJ
cord-300872-blycbi4u	341	3	compounds	compound	NNS
cord-300872-blycbi4u	341	4	were	be	VBD
cord-300872-blycbi4u	341	5	screened	screen	VBN
cord-300872-blycbi4u	341	6	for	for	IN
cord-300872-blycbi4u	341	7	potential	potential	JJ
cord-300872-blycbi4u	341	8	anticancer	anticancer	JJ
cord-300872-blycbi4u	341	9	activity	activity	NN
cord-300872-blycbi4u	341	10	against	against	IN
cord-300872-blycbi4u	341	11	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	341	12	,	,	,
cord-300872-blycbi4u	341	13	HCT	HCT	NNP
cord-300872-blycbi4u	341	14	116	116	CD
cord-300872-blycbi4u	341	15	,	,	,
cord-300872-blycbi4u	341	16	HepG-2	hepg-2	CD
cord-300872-blycbi4u	341	17	,	,	,
cord-300872-blycbi4u	341	18	and	and	CC
cord-300872-blycbi4u	341	19	A549	A549	NNPS
cord-300872-blycbi4u	341	20	using	use	VBG
cord-300872-blycbi4u	341	21	the	the	DT
cord-300872-blycbi4u	341	22	MMT	MMT	NNP
cord-300872-blycbi4u	341	23	assay	assay	NN
cord-300872-blycbi4u	341	24	.	.	.
cord-300872-blycbi4u	342	1	Structure	structure	NN
cord-300872-blycbi4u	342	2	-	-	HYPH
cord-300872-blycbi4u	342	3	activity	activity	NN
cord-300872-blycbi4u	342	4	relationship	relationship	NN
cord-300872-blycbi4u	342	5	(	(	-LRB-
cord-300872-blycbi4u	342	6	SAR	SAR	NNP
cord-300872-blycbi4u	342	7	)	)	-RRB-
cord-300872-blycbi4u	342	8	results	result	NNS
cord-300872-blycbi4u	342	9	revealed	reveal	VBD
cord-300872-blycbi4u	342	10	that	that	IN
cord-300872-blycbi4u	342	11	6-chloroanalogues	6-chloroanalogues	CD
cord-300872-blycbi4u	342	12	were	be	VBD
cord-300872-blycbi4u	342	13	the	the	DT
cord-300872-blycbi4u	342	14	most	most	RBS
cord-300872-blycbi4u	342	15	active	active	JJ
cord-300872-blycbi4u	342	16	,	,	,
cord-300872-blycbi4u	342	17	whereas	whereas	IN
cord-300872-blycbi4u	342	18	the	the	DT
cord-300872-blycbi4u	342	19	9-methylanaloguess	9-methylanaloguess	CD
cord-300872-blycbi4u	342	20	were	be	VBD
cord-300872-blycbi4u	342	21	the	the	DT
cord-300872-blycbi4u	342	22	least	least	JJS
cord-300872-blycbi4u	342	23	potent	potent	JJ
cord-300872-blycbi4u	342	24	.	.	.
cord-300872-blycbi4u	343	1	In	in	IN
cord-300872-blycbi4u	343	2	addition	addition	NN
cord-300872-blycbi4u	343	3	,	,	,
cord-300872-blycbi4u	343	4	the	the	DT
cord-300872-blycbi4u	343	5	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	343	6	of	of	IN
cord-300872-blycbi4u	343	7	the	the	DT
cord-300872-blycbi4u	343	8	products	product	NNS
cord-300872-blycbi4u	343	9	increased	increase	VBD
cord-300872-blycbi4u	343	10	in	in	IN
cord-300872-blycbi4u	343	11	the	the	DT
cord-300872-blycbi4u	343	12	presence	presence	NN
cord-300872-blycbi4u	343	13	of	of	IN
cord-300872-blycbi4u	343	14	halogen	halogen	NNP
cord-300872-blycbi4u	343	15	atom	atom	NN
cord-300872-blycbi4u	343	16	substituents	substituent	NNS
cord-300872-blycbi4u	343	17	at	at	IN
cord-300872-blycbi4u	343	18	positions	position	NNS
cord-300872-blycbi4u	343	19	4	4	CD
cord-300872-blycbi4u	343	20	,	,	,
cord-300872-blycbi4u	343	21	6	6	CD
cord-300872-blycbi4u	343	22	,	,	,
cord-300872-blycbi4u	343	23	and	and	CC
cord-300872-blycbi4u	343	24	9	9	CD
cord-300872-blycbi4u	343	25	.	.	.
cord-300872-blycbi4u	344	1	The	the	DT
cord-300872-blycbi4u	344	2	IC50	IC50	NNP
cord-300872-blycbi4u	344	3	values	value	NNS
cord-300872-blycbi4u	344	4	(	(	-LRB-
cord-300872-blycbi4u	344	5	mg	mg	NN
cord-300872-blycbi4u	344	6	/	/	SYM
cord-300872-blycbi4u	344	7	mL	mL	NNP
cord-300872-blycbi4u	344	8	)	)	-RRB-
cord-300872-blycbi4u	344	9	of	of	IN
cord-300872-blycbi4u	344	10	these	these	DT
cord-300872-blycbi4u	344	11	compounds	compound	NNS
cord-300872-blycbi4u	344	12	were	be	VBD
cord-300872-blycbi4u	344	13	in	in	IN
cord-300872-blycbi4u	344	14	the	the	DT
cord-300872-blycbi4u	344	15	ranges	range	NNS
cord-300872-blycbi4u	344	16	of	of	IN
cord-300872-blycbi4u	344	17	0.9	0.9	CD
cord-300872-blycbi4u	344	18	-	-	SYM
cord-300872-blycbi4u	344	19	38.2	38.2	CD
cord-300872-blycbi4u	344	20	,	,	,
cord-300872-blycbi4u	344	21	1.3	1.3	CD
cord-300872-blycbi4u	344	22	-	-	SYM
cord-300872-blycbi4u	344	23	45.5	45.5	CD
cord-300872-blycbi4u	344	24	,	,	,
cord-300872-blycbi4u	344	25	0.7	0.7	CD
cord-300872-blycbi4u	344	26	-	-	SYM
cord-300872-blycbi4u	344	27	44.5	44.5	CD
cord-300872-blycbi4u	344	28	,	,	,
cord-300872-blycbi4u	344	29	and	and	CC
cord-300872-blycbi4u	344	30	1.23	1.23	CD
cord-300872-blycbi4u	344	31	-	-	SYM
cord-300872-blycbi4u	344	32	36.7	36.7	CD
cord-300872-blycbi4u	344	33	against	against	IN
cord-300872-blycbi4u	344	34	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	344	35	,	,	,
cord-300872-blycbi4u	344	36	HCT	HCT	NNP
cord-300872-blycbi4u	344	37	116	116	CD
cord-300872-blycbi4u	344	38	,	,	,
cord-300872-blycbi4u	344	39	HepG2	HepG2	NNP
cord-300872-blycbi4u	344	40	,	,	,
cord-300872-blycbi4u	344	41	and	and	CC
cord-300872-blycbi4u	344	42	A549	a549	JJ
cord-300872-blycbi4u	344	43	,	,	,
cord-300872-blycbi4u	344	44	respectively	respectively	RB
cord-300872-blycbi4u	344	45	;	;	:
cord-300872-blycbi4u	344	46	while	while	IN
cord-300872-blycbi4u	344	47	the	the	DT
cord-300872-blycbi4u	344	48	colchicine	colchicine	NNP
cord-300872-blycbi4u	344	49	reference	reference	NN
cord-300872-blycbi4u	344	50	showed	show	VBD
cord-300872-blycbi4u	344	51	IC50	ic50	JJ
cord-300872-blycbi4u	344	52	values	value	NNS
cord-300872-blycbi4u	344	53	of	of	IN
cord-300872-blycbi4u	344	54	6.1	6.1	CD
cord-300872-blycbi4u	344	55	,	,	,
cord-300872-blycbi4u	344	56	2.6	2.6	CD
cord-300872-blycbi4u	344	57	,	,	,
cord-300872-blycbi4u	344	58	4.6	4.6	CD
cord-300872-blycbi4u	344	59	,	,	,
cord-300872-blycbi4u	344	60	and	and	CC
cord-300872-blycbi4u	344	61	3.78	3.78	CD
cord-300872-blycbi4u	344	62	mg	mg	NNP
cord-300872-blycbi4u	344	63	/	/	SYM
cord-300872-blycbi4u	344	64	mL	ml	NN
cord-300872-blycbi4u	344	65	,	,	,
cord-300872-blycbi4u	344	66	respectively	respectively	RB
cord-300872-blycbi4u	344	67	.	.	.
cord-300872-blycbi4u	345	1	In	in	IN
cord-300872-blycbi4u	345	2	a	a	DT
cord-300872-blycbi4u	345	3	similar	similar	JJ
cord-300872-blycbi4u	345	4	fashion	fashion	NN
cord-300872-blycbi4u	345	5	,	,	,
cord-300872-blycbi4u	345	6	Chhabra	Chhabra	NNP
cord-300872-blycbi4u	345	7	et	et	NNP
cord-300872-blycbi4u	345	8	al	al	NNP
cord-300872-blycbi4u	345	9	.	.	.
cord-300872-blycbi4u	346	1	(	(	-LRB-
cord-300872-blycbi4u	346	2	2017	2017	CD
cord-300872-blycbi4u	346	3	)	)	-RRB-
cord-300872-blycbi4u	346	4	described	describe	VBD
cord-300872-blycbi4u	346	5	an	an	DT
cord-300872-blycbi4u	346	6	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	346	7	IRA	IRA	NNP
cord-300872-blycbi4u	346	8	402(OH)-mediated	402(oh)-mediated	CD
cord-300872-blycbi4u	346	9	synthesis	synthesis	NN
cord-300872-blycbi4u	346	10	of	of	IN
cord-300872-blycbi4u	346	11	novel	novel	JJ
cord-300872-blycbi4u	346	12	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	346	13	-	-	HYPH
cord-300872-blycbi4u	346	14	quinoline	quinoline	NN
cord-300872-blycbi4u	346	15	conjugates	conjugate	NNS
cord-300872-blycbi4u	346	16	with	with	IN
cord-300872-blycbi4u	346	17	excellent	excellent	JJ
cord-300872-blycbi4u	346	18	yields	yield	NNS
cord-300872-blycbi4u	346	19	[	[	-LRB-
cord-300872-blycbi4u	346	20	34	34	CD
cord-300872-blycbi4u	346	21	]	]	-RRB-
cord-300872-blycbi4u	346	22	.	.	.
cord-300872-blycbi4u	347	1	A	a	DT
cord-300872-blycbi4u	347	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	347	3	procedure	procedure	NN
cord-300872-blycbi4u	347	4	(	(	-LRB-
cord-300872-blycbi4u	347	5	Scheme	scheme	NN
cord-300872-blycbi4u	347	6	13	13	CD
cord-300872-blycbi4u	347	7	)	)	-RRB-
cord-300872-blycbi4u	347	8	involved	involve	VBD
cord-300872-blycbi4u	347	9	a	a	DT
cord-300872-blycbi4u	347	10	condensation	condensation	NN
cord-300872-blycbi4u	347	11	reaction	reaction	NN
cord-300872-blycbi4u	347	12	between	between	IN
cord-300872-blycbi4u	347	13	the	the	DT
cord-300872-blycbi4u	347	14	amino	amino	NN
cord-300872-blycbi4u	347	15	group	group	NN
cord-300872-blycbi4u	347	16	(	(	-LRB-
cord-300872-blycbi4u	347	17	NH2	NH2	NNP
cord-300872-blycbi4u	347	18	)	)	-RRB-
cord-300872-blycbi4u	347	19	in	in	IN
cord-300872-blycbi4u	347	20	49	49	CD
cord-300872-blycbi4u	347	21	and	and	CC
cord-300872-blycbi4u	347	22	the	the	DT
cord-300872-blycbi4u	347	23	carbonyl	carbonyl	NN
cord-300872-blycbi4u	347	24	group	group	NN
cord-300872-blycbi4u	347	25	in	in	IN
cord-300872-blycbi4u	347	26	salicylic	salicylic	JJ
cord-300872-blycbi4u	347	27	aldehyde	aldehyde	NN
cord-300872-blycbi4u	347	28	(	(	-LRB-
cord-300872-blycbi4u	347	29	50	50	CD
cord-300872-blycbi4u	347	30	)	)	-RRB-
cord-300872-blycbi4u	347	31	,	,	,
cord-300872-blycbi4u	347	32	followed	follow	VBN
cord-300872-blycbi4u	347	33	by	by	IN
cord-300872-blycbi4u	347	34	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	347	35	cyclization	cyclization	NN
cord-300872-blycbi4u	347	36	under	under	IN
cord-300872-blycbi4u	347	37	a	a	DT
cord-300872-blycbi4u	347	38	These	these	DT
cord-300872-blycbi4u	347	39	prepared	prepared	JJ
cord-300872-blycbi4u	347	40	compounds	compound	NNS
cord-300872-blycbi4u	347	41	were	be	VBD
cord-300872-blycbi4u	347	42	screened	screen	VBN
cord-300872-blycbi4u	347	43	for	for	IN
cord-300872-blycbi4u	347	44	potential	potential	JJ
cord-300872-blycbi4u	347	45	anticancer	anticancer	JJ
cord-300872-blycbi4u	347	46	activity	activity	NN
cord-300872-blycbi4u	347	47	against	against	IN
cord-300872-blycbi4u	347	48	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	347	49	,	,	,
cord-300872-blycbi4u	347	50	HCT	HCT	NNP
cord-300872-blycbi4u	347	51	116	116	CD
cord-300872-blycbi4u	347	52	,	,	,
cord-300872-blycbi4u	347	53	HepG-2	hepg-2	CD
cord-300872-blycbi4u	347	54	,	,	,
cord-300872-blycbi4u	347	55	and	and	CC
cord-300872-blycbi4u	347	56	A549	A549	NNPS
cord-300872-blycbi4u	347	57	using	use	VBG
cord-300872-blycbi4u	347	58	the	the	DT
cord-300872-blycbi4u	347	59	MMT	MMT	NNP
cord-300872-blycbi4u	347	60	assay	assay	NN
cord-300872-blycbi4u	347	61	.	.	.
cord-300872-blycbi4u	348	1	Structure	structure	NN
cord-300872-blycbi4u	348	2	-	-	HYPH
cord-300872-blycbi4u	348	3	activity	activity	NN
cord-300872-blycbi4u	348	4	relationship	relationship	NN
cord-300872-blycbi4u	348	5	(	(	-LRB-
cord-300872-blycbi4u	348	6	SAR	SAR	NNP
cord-300872-blycbi4u	348	7	)	)	-RRB-
cord-300872-blycbi4u	348	8	results	result	NNS
cord-300872-blycbi4u	348	9	revealed	reveal	VBD
cord-300872-blycbi4u	348	10	that	that	IN
cord-300872-blycbi4u	348	11	6-chloroanalogues	6-chloroanalogues	CD
cord-300872-blycbi4u	348	12	were	be	VBD
cord-300872-blycbi4u	348	13	the	the	DT
cord-300872-blycbi4u	348	14	most	most	RBS
cord-300872-blycbi4u	348	15	active	active	JJ
cord-300872-blycbi4u	348	16	,	,	,
cord-300872-blycbi4u	348	17	whereas	whereas	IN
cord-300872-blycbi4u	348	18	the	the	DT
cord-300872-blycbi4u	348	19	9-methylanaloguess	9-methylanaloguess	CD
cord-300872-blycbi4u	348	20	were	be	VBD
cord-300872-blycbi4u	348	21	the	the	DT
cord-300872-blycbi4u	348	22	least	least	JJS
cord-300872-blycbi4u	348	23	potent	potent	JJ
cord-300872-blycbi4u	348	24	.	.	.
cord-300872-blycbi4u	349	1	In	in	IN
cord-300872-blycbi4u	349	2	addition	addition	NN
cord-300872-blycbi4u	349	3	,	,	,
cord-300872-blycbi4u	349	4	the	the	DT
cord-300872-blycbi4u	349	5	lipophilicity	lipophilicity	NN
cord-300872-blycbi4u	349	6	of	of	IN
cord-300872-blycbi4u	349	7	the	the	DT
cord-300872-blycbi4u	349	8	products	product	NNS
cord-300872-blycbi4u	349	9	increased	increase	VBD
cord-300872-blycbi4u	349	10	in	in	IN
cord-300872-blycbi4u	349	11	the	the	DT
cord-300872-blycbi4u	349	12	presence	presence	NN
cord-300872-blycbi4u	349	13	of	of	IN
cord-300872-blycbi4u	349	14	halogen	halogen	NNP
cord-300872-blycbi4u	349	15	atom	atom	NN
cord-300872-blycbi4u	349	16	substituents	substituent	NNS
cord-300872-blycbi4u	349	17	at	at	IN
cord-300872-blycbi4u	349	18	positions	position	NNS
cord-300872-blycbi4u	349	19	4	4	CD
cord-300872-blycbi4u	349	20	,	,	,
cord-300872-blycbi4u	349	21	6	6	CD
cord-300872-blycbi4u	349	22	,	,	,
cord-300872-blycbi4u	349	23	and	and	CC
cord-300872-blycbi4u	349	24	9	9	CD
cord-300872-blycbi4u	349	25	.	.	.
cord-300872-blycbi4u	350	1	The	the	DT
cord-300872-blycbi4u	350	2	IC	IC	NNP
cord-300872-blycbi4u	350	3	50	50	CD
cord-300872-blycbi4u	350	4	values	value	NNS
cord-300872-blycbi4u	350	5	(	(	-LRB-
cord-300872-blycbi4u	350	6	mg	mg	NN
cord-300872-blycbi4u	350	7	/	/	SYM
cord-300872-blycbi4u	350	8	mL	mL	NNP
cord-300872-blycbi4u	350	9	)	)	-RRB-
cord-300872-blycbi4u	350	10	of	of	IN
cord-300872-blycbi4u	350	11	these	these	DT
cord-300872-blycbi4u	350	12	compounds	compound	NNS
cord-300872-blycbi4u	350	13	were	be	VBD
cord-300872-blycbi4u	350	14	in	in	IN
cord-300872-blycbi4u	350	15	the	the	DT
cord-300872-blycbi4u	350	16	ranges	range	NNS
cord-300872-blycbi4u	350	17	of	of	IN
cord-300872-blycbi4u	350	18	0.9	0.9	CD
cord-300872-blycbi4u	350	19	-	-	SYM
cord-300872-blycbi4u	350	20	38.2	38.2	CD
cord-300872-blycbi4u	350	21	,	,	,
cord-300872-blycbi4u	350	22	1.3	1.3	CD
cord-300872-blycbi4u	350	23	-	-	SYM
cord-300872-blycbi4u	350	24	45.5	45.5	CD
cord-300872-blycbi4u	350	25	,	,	,
cord-300872-blycbi4u	350	26	0.7	0.7	CD
cord-300872-blycbi4u	350	27	-	-	SYM
cord-300872-blycbi4u	350	28	44.5	44.5	CD
cord-300872-blycbi4u	350	29	,	,	,
cord-300872-blycbi4u	350	30	and	and	CC
cord-300872-blycbi4u	350	31	1.23	1.23	CD
cord-300872-blycbi4u	350	32	-	-	SYM
cord-300872-blycbi4u	350	33	36.7	36.7	CD
cord-300872-blycbi4u	350	34	against	against	IN
cord-300872-blycbi4u	350	35	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	350	36	,	,	,
cord-300872-blycbi4u	350	37	HCT	HCT	NNP
cord-300872-blycbi4u	350	38	116	116	CD
cord-300872-blycbi4u	350	39	,	,	,
cord-300872-blycbi4u	350	40	HepG2	HepG2	NNP
cord-300872-blycbi4u	350	41	,	,	,
cord-300872-blycbi4u	350	42	and	and	CC
cord-300872-blycbi4u	350	43	A549	a549	JJ
cord-300872-blycbi4u	350	44	,	,	,
cord-300872-blycbi4u	350	45	respectively	respectively	RB
cord-300872-blycbi4u	350	46	;	;	:
cord-300872-blycbi4u	350	47	while	while	IN
cord-300872-blycbi4u	350	48	the	the	DT
cord-300872-blycbi4u	350	49	colchicine	colchicine	NNP
cord-300872-blycbi4u	350	50	reference	reference	NN
cord-300872-blycbi4u	350	51	showed	show	VBD
cord-300872-blycbi4u	350	52	IC	IC	NNP
cord-300872-blycbi4u	350	53	50	50	CD
cord-300872-blycbi4u	350	54	values	value	NNS
cord-300872-blycbi4u	350	55	of	of	IN
cord-300872-blycbi4u	350	56	6.1	6.1	CD
cord-300872-blycbi4u	350	57	,	,	,
cord-300872-blycbi4u	350	58	2.6	2.6	CD
cord-300872-blycbi4u	350	59	,	,	,
cord-300872-blycbi4u	350	60	4.6	4.6	CD
cord-300872-blycbi4u	350	61	,	,	,
cord-300872-blycbi4u	350	62	and	and	CC
cord-300872-blycbi4u	350	63	3.78	3.78	CD
cord-300872-blycbi4u	350	64	mg	mg	NNP
cord-300872-blycbi4u	350	65	/	/	SYM
cord-300872-blycbi4u	350	66	mL	ml	NN
cord-300872-blycbi4u	350	67	,	,	,
cord-300872-blycbi4u	350	68	respectively	respectively	RB
cord-300872-blycbi4u	350	69	.	.	.
cord-300872-blycbi4u	351	1	In	in	IN
cord-300872-blycbi4u	351	2	a	a	DT
cord-300872-blycbi4u	351	3	similar	similar	JJ
cord-300872-blycbi4u	351	4	fashion	fashion	NN
cord-300872-blycbi4u	351	5	,	,	,
cord-300872-blycbi4u	351	6	Chhabra	Chhabra	NNP
cord-300872-blycbi4u	351	7	et	et	NNP
cord-300872-blycbi4u	351	8	al	al	NNP
cord-300872-blycbi4u	351	9	.	.	.
cord-300872-blycbi4u	352	1	(	(	-LRB-
cord-300872-blycbi4u	352	2	2017	2017	CD
cord-300872-blycbi4u	352	3	)	)	-RRB-
cord-300872-blycbi4u	352	4	described	describe	VBD
cord-300872-blycbi4u	352	5	an	an	DT
cord-300872-blycbi4u	352	6	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	352	7	IRA	IRA	NNP
cord-300872-blycbi4u	352	8	402(OH)-mediated	402(oh)-mediated	CD
cord-300872-blycbi4u	352	9	synthesis	synthesis	NN
cord-300872-blycbi4u	352	10	of	of	IN
cord-300872-blycbi4u	352	11	novel	novel	JJ
cord-300872-blycbi4u	352	12	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	352	13	-	-	HYPH
cord-300872-blycbi4u	352	14	quinoline	quinoline	NN
cord-300872-blycbi4u	352	15	conjugates	conjugate	NNS
cord-300872-blycbi4u	352	16	with	with	IN
cord-300872-blycbi4u	352	17	excellent	excellent	JJ
cord-300872-blycbi4u	352	18	yields	yield	NNS
cord-300872-blycbi4u	352	19	[	[	-LRB-
cord-300872-blycbi4u	352	20	34	34	CD
cord-300872-blycbi4u	352	21	]	]	-RRB-
cord-300872-blycbi4u	352	22	.	.	.
cord-300872-blycbi4u	353	1	A	a	DT
cord-300872-blycbi4u	353	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	353	3	procedure	procedure	NN
cord-300872-blycbi4u	353	4	(	(	-LRB-
cord-300872-blycbi4u	353	5	Scheme	scheme	NN
cord-300872-blycbi4u	353	6	13	13	CD
cord-300872-blycbi4u	353	7	)	)	-RRB-
cord-300872-blycbi4u	353	8	involved	involve	VBD
cord-300872-blycbi4u	353	9	a	a	DT
cord-300872-blycbi4u	353	10	condensation	condensation	NN
cord-300872-blycbi4u	353	11	reaction	reaction	NN
cord-300872-blycbi4u	353	12	between	between	IN
cord-300872-blycbi4u	353	13	the	the	DT
cord-300872-blycbi4u	353	14	amino	amino	NN
cord-300872-blycbi4u	353	15	group	group	NN
cord-300872-blycbi4u	353	16	(	(	-LRB-
cord-300872-blycbi4u	353	17	NH	NH	NNP
cord-300872-blycbi4u	353	18	2	2	CD
cord-300872-blycbi4u	353	19	)	)	-RRB-
cord-300872-blycbi4u	353	20	in	in	IN
cord-300872-blycbi4u	353	21	49	49	CD
cord-300872-blycbi4u	353	22	and	and	CC
cord-300872-blycbi4u	353	23	the	the	DT
cord-300872-blycbi4u	353	24	carbonyl	carbonyl	NN
cord-300872-blycbi4u	353	25	group	group	NN
cord-300872-blycbi4u	353	26	in	in	IN
cord-300872-blycbi4u	353	27	salicylic	salicylic	JJ
cord-300872-blycbi4u	353	28	aldehyde	aldehyde	NN
cord-300872-blycbi4u	353	29	(	(	-LRB-
cord-300872-blycbi4u	353	30	50	50	CD
cord-300872-blycbi4u	353	31	)	)	-RRB-
cord-300872-blycbi4u	353	32	,	,	,
cord-300872-blycbi4u	353	33	followed	follow	VBN
cord-300872-blycbi4u	353	34	by	by	IN
cord-300872-blycbi4u	353	35	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	353	36	cyclization	cyclization	NN
cord-300872-blycbi4u	353	37	under	under	IN
cord-300872-blycbi4u	353	38	a	a	DT
cord-300872-blycbi4u	353	39	microwave	microwave	NN
cord-300872-blycbi4u	353	40	approach	approach	NN
cord-300872-blycbi4u	353	41	to	to	TO
cord-300872-blycbi4u	353	42	form	form	VB
cord-300872-blycbi4u	353	43	the	the	DT
cord-300872-blycbi4u	353	44	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	353	45	(	(	-LRB-
cord-300872-blycbi4u	353	46	51	51	CD
cord-300872-blycbi4u	353	47	)	)	-RRB-
cord-300872-blycbi4u	353	48	.	.	.
cord-300872-blycbi4u	354	1	The	the	DT
cord-300872-blycbi4u	354	2	reaction	reaction	NN
cord-300872-blycbi4u	354	3	between	between	IN
cord-300872-blycbi4u	354	4	51	51	CD
cord-300872-blycbi4u	354	5	and	and	CC
cord-300872-blycbi4u	354	6	5,7-dialkyl-8-hydroxyquinoline	5,7-dialkyl-8-hydroxyquinoline	CD
cord-300872-blycbi4u	354	7	as	as	IN
cord-300872-blycbi4u	354	8	a	a	DT
cord-300872-blycbi4u	354	9	phenolate	phenolate	NN
cord-300872-blycbi4u	354	10	ion	ion	NN
cord-300872-blycbi4u	354	11	in	in	IN
cord-300872-blycbi4u	354	12	the	the	DT
cord-300872-blycbi4u	354	13	presence	presence	NN
cord-300872-blycbi4u	354	14	of	of	IN
cord-300872-blycbi4u	354	15	a	a	DT
cord-300872-blycbi4u	354	16	catalytic	catalytic	JJ
cord-300872-blycbi4u	354	17	amount	amount	NN
cord-300872-blycbi4u	354	18	of	of	IN
cord-300872-blycbi4u	354	19	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	354	20	IRA	IRA	NNP
cord-300872-blycbi4u	354	21	and	and	CC
cord-300872-blycbi4u	354	22	an	an	DT
cord-300872-blycbi4u	354	23	excess	excess	JJ
cord-300872-blycbi4u	354	24	amount	amount	NN
cord-300872-blycbi4u	354	25	of	of	IN
cord-300872-blycbi4u	354	26	dibromoalkane	dibromoalkane	NN
cord-300872-blycbi4u	354	27	under	under	IN
cord-300872-blycbi4u	354	28	microwave	microwave	NN
cord-300872-blycbi4u	354	29	conditions	condition	NNS
cord-300872-blycbi4u	354	30	afforded	afford	VBD
cord-300872-blycbi4u	354	31	the	the	DT
cord-300872-blycbi4u	354	32	target	target	NN
cord-300872-blycbi4u	354	33	product	product	NN
cord-300872-blycbi4u	354	34	52	52	CD
cord-300872-blycbi4u	354	35	;	;	:
cord-300872-blycbi4u	354	36	dibromoalkanes	dibromoalkane	NNS
cord-300872-blycbi4u	354	37	were	be	VBD
cord-300872-blycbi4u	354	38	employed	employ	VBN
cord-300872-blycbi4u	354	39	as	as	IN
cord-300872-blycbi4u	354	40	linkers	linker	NNS
cord-300872-blycbi4u	354	41	between	between	IN
cord-300872-blycbi4u	354	42	the	the	DT
cord-300872-blycbi4u	354	43	two	two	CD
cord-300872-blycbi4u	354	44	fragments	fragment	NNS
cord-300872-blycbi4u	354	45	,	,	,
cord-300872-blycbi4u	354	46	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	354	47	and	and	CC
cord-300872-blycbi4u	354	48	2-benzothiazol-2-ylphenol	2-benzothiazol-2-ylphenol	CD
cord-300872-blycbi4u	354	49	.	.	.
cord-300872-blycbi4u	355	1	The	the	DT
cord-300872-blycbi4u	355	2	prepared	prepared	JJ
cord-300872-blycbi4u	355	3	compounds	compound	NNS
cord-300872-blycbi4u	355	4	were	be	VBD
cord-300872-blycbi4u	355	5	then	then	RB
cord-300872-blycbi4u	355	6	subjected	subject	VBN
cord-300872-blycbi4u	355	7	to	to	IN
cord-300872-blycbi4u	355	8	a	a	DT
cord-300872-blycbi4u	355	9	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	355	10	study	study	NN
cord-300872-blycbi4u	355	11	along	along	IN
cord-300872-blycbi4u	355	12	with	with	IN
cord-300872-blycbi4u	355	13	cisplatin	cisplatin	NN
cord-300872-blycbi4u	355	14	(	(	-LRB-
cord-300872-blycbi4u	355	15	a	a	DT
cord-300872-blycbi4u	355	16	positive	positive	JJ
cord-300872-blycbi4u	355	17	control	control	NN
cord-300872-blycbi4u	355	18	)	)	-RRB-
cord-300872-blycbi4u	355	19	against	against	IN
cord-300872-blycbi4u	355	20	a	a	DT
cord-300872-blycbi4u	355	21	panel	panel	NN
cord-300872-blycbi4u	355	22	of	of	IN
cord-300872-blycbi4u	355	23	cancer	cancer	NN
cord-300872-blycbi4u	355	24	cell	cell	NN
cord-300872-blycbi4u	355	25	lines	line	NNS
cord-300872-blycbi4u	355	26	,	,	,
cord-300872-blycbi4u	355	27	including	include	VBG
cord-300872-blycbi4u	355	28	HeLa	HeLa	NNP
cord-300872-blycbi4u	355	29	,	,	,
cord-300872-blycbi4u	355	30	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	355	31	,	,	,
cord-300872-blycbi4u	355	32	A549	a549	JJ
cord-300872-blycbi4u	355	33	,	,	,
cord-300872-blycbi4u	355	34	and	and	CC
cord-300872-blycbi4u	355	35	human	human	JJ
cord-300872-blycbi4u	355	36	ovarian	ovarian	JJ
cord-300872-blycbi4u	355	37	carcinoma	carcinoma	NN
cord-300872-blycbi4u	355	38	(	(	-LRB-
cord-300872-blycbi4u	355	39	A2780	A2780	NNP
cord-300872-blycbi4u	355	40	)	)	-RRB-
cord-300872-blycbi4u	355	41	,	,	,
cord-300872-blycbi4u	355	42	using	use	VBG
cord-300872-blycbi4u	355	43	the	the	DT
cord-300872-blycbi4u	355	44	MMT	MMT	NNP
cord-300872-blycbi4u	355	45	assay	assay	NN
cord-300872-blycbi4u	355	46	.	.	.
cord-300872-blycbi4u	356	1	Most	Most	JJS
cord-300872-blycbi4u	356	2	of	of	IN
cord-300872-blycbi4u	356	3	the	the	DT
cord-300872-blycbi4u	356	4	prepared	prepared	JJ
cord-300872-blycbi4u	356	5	compounds	compound	NNS
cord-300872-blycbi4u	356	6	were	be	VBD
cord-300872-blycbi4u	356	7	more	more	RBR
cord-300872-blycbi4u	356	8	potent	potent	JJ
cord-300872-blycbi4u	356	9	than	than	IN
cord-300872-blycbi4u	356	10	cisplatin	cisplatin	NN
cord-300872-blycbi4u	356	11	,	,	,
cord-300872-blycbi4u	356	12	with	with	IN
cord-300872-blycbi4u	356	13	IC	IC	NNP
cord-300872-blycbi4u	356	14	50	50	CD
cord-300872-blycbi4u	356	15	values	value	NNS
cord-300872-blycbi4u	356	16	in	in	IN
cord-300872-blycbi4u	356	17	the	the	DT
cord-300872-blycbi4u	356	18	ranges	range	NNS
cord-300872-blycbi4u	356	19	of	of	IN
cord-300872-blycbi4u	356	20	5	5	CD
cord-300872-blycbi4u	356	21	-	-	SYM
cord-300872-blycbi4u	356	22	19	19	CD
cord-300872-blycbi4u	356	23	,	,	,
cord-300872-blycbi4u	356	24	7	7	CD
cord-300872-blycbi4u	356	25	-	-	SYM
cord-300872-blycbi4u	356	26	49	49	CD
cord-300872-blycbi4u	356	27	,	,	,
cord-300872-blycbi4u	356	28	10	10	CD
cord-300872-blycbi4u	356	29	-	-	SYM
cord-300872-blycbi4u	356	30	30	30	CD
cord-300872-blycbi4u	356	31	,	,	,
cord-300872-blycbi4u	356	32	and	and	CC
cord-300872-blycbi4u	356	33	10	10	CD
cord-300872-blycbi4u	356	34	-	-	SYM
cord-300872-blycbi4u	356	35	38	38	CD
cord-300872-blycbi4u	356	36	mM	mm	NN
cord-300872-blycbi4u	356	37	against	against	IN
cord-300872-blycbi4u	356	38	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	356	39	,	,	,
cord-300872-blycbi4u	356	40	HeLa	HeLa	NNP
cord-300872-blycbi4u	356	41	cells	cell	NNS
cord-300872-blycbi4u	356	42	,	,	,
cord-300872-blycbi4u	356	43	A2780	A2780	NNP
cord-300872-blycbi4u	356	44	,	,	,
cord-300872-blycbi4u	356	45	and	and	CC
cord-300872-blycbi4u	356	46	A549	A549	NNPS
cord-300872-blycbi4u	356	47	,	,	,
cord-300872-blycbi4u	356	48	respectively	respectively	RB
cord-300872-blycbi4u	356	49	.	.	.
cord-300872-blycbi4u	357	1	In	in	IN
cord-300872-blycbi4u	357	2	addition	addition	NN
cord-300872-blycbi4u	357	3	,	,	,
cord-300872-blycbi4u	357	4	the	the	DT
cord-300872-blycbi4u	357	5	target	target	NN
cord-300872-blycbi4u	357	6	products	product	NNS
cord-300872-blycbi4u	357	7	were	be	VBD
cord-300872-blycbi4u	357	8	3	3	CD
cord-300872-blycbi4u	357	9	-	-	SYM
cord-300872-blycbi4u	357	10	25-fold	25-fold	JJ
cord-300872-blycbi4u	357	11	more	more	RBR
cord-300872-blycbi4u	357	12	selective	selective	JJ
cord-300872-blycbi4u	357	13	in	in	IN
cord-300872-blycbi4u	357	14	cancer	cancer	NN
cord-300872-blycbi4u	357	15	cell	cell	NN
cord-300872-blycbi4u	357	16	lines	line	NNS
cord-300872-blycbi4u	357	17	than	than	IN
cord-300872-blycbi4u	357	18	normal	normal	JJ
cord-300872-blycbi4u	357	19	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	357	20	.	.	.
cord-300872-blycbi4u	358	1	Molecules	molecule	NNS
cord-300872-blycbi4u	358	2	2020	2020	CD
cord-300872-blycbi4u	358	3	,	,	,
cord-300872-blycbi4u	358	4	25	25	CD
cord-300872-blycbi4u	358	5	,	,	,
cord-300872-blycbi4u	358	6	x	x	NN
cord-300872-blycbi4u	358	7	FOR	for	IN
cord-300872-blycbi4u	358	8	PEER	PEER	NNP
cord-300872-blycbi4u	358	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	358	10	12	12	CD
cord-300872-blycbi4u	358	11	of	of	IN
cord-300872-blycbi4u	358	12	26	26	CD
cord-300872-blycbi4u	358	13	microwave	microwave	NN
cord-300872-blycbi4u	358	14	approach	approach	NN
cord-300872-blycbi4u	358	15	to	to	TO
cord-300872-blycbi4u	358	16	form	form	VB
cord-300872-blycbi4u	358	17	the	the	DT
cord-300872-blycbi4u	358	18	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	358	19	(	(	-LRB-
cord-300872-blycbi4u	358	20	51	51	CD
cord-300872-blycbi4u	358	21	)	)	-RRB-
cord-300872-blycbi4u	358	22	.	.	.
cord-300872-blycbi4u	359	1	The	the	DT
cord-300872-blycbi4u	359	2	reaction	reaction	NN
cord-300872-blycbi4u	359	3	between	between	IN
cord-300872-blycbi4u	359	4	51	51	CD
cord-300872-blycbi4u	359	5	and	and	CC
cord-300872-blycbi4u	359	6	5,7-dialkyl-8hydroxyquinoline	5,7-dialkyl-8hydroxyquinoline	CD
cord-300872-blycbi4u	359	7	as	as	IN
cord-300872-blycbi4u	359	8	a	a	DT
cord-300872-blycbi4u	359	9	phenolate	phenolate	NN
cord-300872-blycbi4u	359	10	ion	ion	NN
cord-300872-blycbi4u	359	11	in	in	IN
cord-300872-blycbi4u	359	12	the	the	DT
cord-300872-blycbi4u	359	13	presence	presence	NN
cord-300872-blycbi4u	359	14	of	of	IN
cord-300872-blycbi4u	359	15	a	a	DT
cord-300872-blycbi4u	359	16	catalytic	catalytic	JJ
cord-300872-blycbi4u	359	17	amount	amount	NN
cord-300872-blycbi4u	359	18	of	of	IN
cord-300872-blycbi4u	359	19	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	359	20	IRA	IRA	NNP
cord-300872-blycbi4u	359	21	and	and	CC
cord-300872-blycbi4u	359	22	an	an	DT
cord-300872-blycbi4u	359	23	excess	excess	JJ
cord-300872-blycbi4u	359	24	amount	amount	NN
cord-300872-blycbi4u	359	25	of	of	IN
cord-300872-blycbi4u	359	26	dibromoalkane	dibromoalkane	NN
cord-300872-blycbi4u	359	27	under	under	IN
cord-300872-blycbi4u	359	28	microwave	microwave	NN
cord-300872-blycbi4u	359	29	conditions	condition	NNS
cord-300872-blycbi4u	359	30	afforded	afford	VBD
cord-300872-blycbi4u	359	31	the	the	DT
cord-300872-blycbi4u	359	32	target	target	NN
cord-300872-blycbi4u	359	33	product	product	NN
cord-300872-blycbi4u	359	34	52	52	CD
cord-300872-blycbi4u	359	35	;	;	:
cord-300872-blycbi4u	359	36	dibromoalkanes	dibromoalkane	NNS
cord-300872-blycbi4u	359	37	were	be	VBD
cord-300872-blycbi4u	359	38	employed	employ	VBN
cord-300872-blycbi4u	359	39	as	as	IN
cord-300872-blycbi4u	359	40	linkers	linker	NNS
cord-300872-blycbi4u	359	41	between	between	IN
cord-300872-blycbi4u	359	42	the	the	DT
cord-300872-blycbi4u	359	43	two	two	CD
cord-300872-blycbi4u	359	44	fragments	fragment	NNS
cord-300872-blycbi4u	359	45	,	,	,
cord-300872-blycbi4u	359	46	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	359	47	and	and	CC
cord-300872-blycbi4u	359	48	2benzothiazol-2-ylphenol	2benzothiazol-2-ylphenol	CD
cord-300872-blycbi4u	359	49	.	.	.
cord-300872-blycbi4u	360	1	The	the	DT
cord-300872-blycbi4u	360	2	prepared	prepared	JJ
cord-300872-blycbi4u	360	3	compounds	compound	NNS
cord-300872-blycbi4u	360	4	were	be	VBD
cord-300872-blycbi4u	360	5	then	then	RB
cord-300872-blycbi4u	360	6	subjected	subject	VBN
cord-300872-blycbi4u	360	7	to	to	IN
cord-300872-blycbi4u	360	8	a	a	DT
cord-300872-blycbi4u	360	9	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	360	10	study	study	NN
cord-300872-blycbi4u	360	11	along	along	IN
cord-300872-blycbi4u	360	12	with	with	IN
cord-300872-blycbi4u	360	13	cisplatin	cisplatin	NN
cord-300872-blycbi4u	360	14	(	(	-LRB-
cord-300872-blycbi4u	360	15	a	a	DT
cord-300872-blycbi4u	360	16	positive	positive	JJ
cord-300872-blycbi4u	360	17	control	control	NN
cord-300872-blycbi4u	360	18	)	)	-RRB-
cord-300872-blycbi4u	360	19	against	against	IN
cord-300872-blycbi4u	360	20	a	a	DT
cord-300872-blycbi4u	360	21	panel	panel	NN
cord-300872-blycbi4u	360	22	of	of	IN
cord-300872-blycbi4u	360	23	cancer	cancer	NN
cord-300872-blycbi4u	360	24	cell	cell	NN
cord-300872-blycbi4u	360	25	lines	line	NNS
cord-300872-blycbi4u	360	26	,	,	,
cord-300872-blycbi4u	360	27	including	include	VBG
cord-300872-blycbi4u	360	28	HeLa	HeLa	NNP
cord-300872-blycbi4u	360	29	,	,	,
cord-300872-blycbi4u	360	30	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	360	31	,	,	,
cord-300872-blycbi4u	360	32	A549	a549	JJ
cord-300872-blycbi4u	360	33	,	,	,
cord-300872-blycbi4u	360	34	and	and	CC
cord-300872-blycbi4u	360	35	human	human	JJ
cord-300872-blycbi4u	360	36	ovarian	ovarian	JJ
cord-300872-blycbi4u	360	37	carcinoma	carcinoma	NN
cord-300872-blycbi4u	360	38	(	(	-LRB-
cord-300872-blycbi4u	360	39	A2780	A2780	NNP
cord-300872-blycbi4u	360	40	)	)	-RRB-
cord-300872-blycbi4u	360	41	,	,	,
cord-300872-blycbi4u	360	42	using	use	VBG
cord-300872-blycbi4u	360	43	the	the	DT
cord-300872-blycbi4u	360	44	MMT	MMT	NNP
cord-300872-blycbi4u	360	45	assay	assay	NN
cord-300872-blycbi4u	360	46	.	.	.
cord-300872-blycbi4u	361	1	Most	Most	JJS
cord-300872-blycbi4u	361	2	of	of	IN
cord-300872-blycbi4u	361	3	the	the	DT
cord-300872-blycbi4u	361	4	prepared	prepared	JJ
cord-300872-blycbi4u	361	5	compounds	compound	NNS
cord-300872-blycbi4u	361	6	were	be	VBD
cord-300872-blycbi4u	361	7	more	more	RBR
cord-300872-blycbi4u	361	8	potent	potent	JJ
cord-300872-blycbi4u	361	9	than	than	IN
cord-300872-blycbi4u	361	10	cisplatin	cisplatin	NN
cord-300872-blycbi4u	361	11	,	,	,
cord-300872-blycbi4u	361	12	with	with	IN
cord-300872-blycbi4u	361	13	IC50	ic50	JJ
cord-300872-blycbi4u	361	14	values	value	NNS
cord-300872-blycbi4u	361	15	in	in	IN
cord-300872-blycbi4u	361	16	the	the	DT
cord-300872-blycbi4u	361	17	ranges	range	NNS
cord-300872-blycbi4u	361	18	of	of	IN
cord-300872-blycbi4u	361	19	5	5	CD
cord-300872-blycbi4u	361	20	-	-	SYM
cord-300872-blycbi4u	361	21	19	19	CD
cord-300872-blycbi4u	361	22	,	,	,
cord-300872-blycbi4u	361	23	7	7	CD
cord-300872-blycbi4u	361	24	-	-	SYM
cord-300872-blycbi4u	361	25	49	49	CD
cord-300872-blycbi4u	361	26	,	,	,
cord-300872-blycbi4u	361	27	10	10	CD
cord-300872-blycbi4u	361	28	-	-	SYM
cord-300872-blycbi4u	361	29	30	30	CD
cord-300872-blycbi4u	361	30	,	,	,
cord-300872-blycbi4u	361	31	and	and	CC
cord-300872-blycbi4u	361	32	10	10	CD
cord-300872-blycbi4u	361	33	-	-	SYM
cord-300872-blycbi4u	361	34	38	38	CD
cord-300872-blycbi4u	361	35	mM	mm	NN
cord-300872-blycbi4u	361	36	against	against	IN
cord-300872-blycbi4u	361	37	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	361	38	,	,	,
cord-300872-blycbi4u	361	39	HeLa	HeLa	NNP
cord-300872-blycbi4u	361	40	cells	cell	NNS
cord-300872-blycbi4u	361	41	,	,	,
cord-300872-blycbi4u	361	42	A2780	A2780	NNP
cord-300872-blycbi4u	361	43	,	,	,
cord-300872-blycbi4u	361	44	and	and	CC
cord-300872-blycbi4u	361	45	A549	A549	NNPS
cord-300872-blycbi4u	361	46	,	,	,
cord-300872-blycbi4u	361	47	respectively	respectively	RB
cord-300872-blycbi4u	361	48	.	.	.
cord-300872-blycbi4u	362	1	In	in	IN
cord-300872-blycbi4u	362	2	addition	addition	NN
cord-300872-blycbi4u	362	3	,	,	,
cord-300872-blycbi4u	362	4	the	the	DT
cord-300872-blycbi4u	362	5	target	target	NN
cord-300872-blycbi4u	362	6	products	product	NNS
cord-300872-blycbi4u	362	7	were	be	VBD
cord-300872-blycbi4u	362	8	3	3	CD
cord-300872-blycbi4u	362	9	-	-	SYM
cord-300872-blycbi4u	362	10	25-fold	25-fold	JJ
cord-300872-blycbi4u	362	11	more	more	RBR
cord-300872-blycbi4u	362	12	selective	selective	JJ
cord-300872-blycbi4u	362	13	in	in	IN
cord-300872-blycbi4u	362	14	cancer	cancer	NN
cord-300872-blycbi4u	362	15	cell	cell	NN
cord-300872-blycbi4u	362	16	lines	line	NNS
cord-300872-blycbi4u	362	17	than	than	IN
cord-300872-blycbi4u	362	18	normal	normal	JJ
cord-300872-blycbi4u	362	19	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	362	20	.	.	.
cord-300872-blycbi4u	363	1	Gayathri	Gayathri	NNP
cord-300872-blycbi4u	363	2	and	and	CC
cord-300872-blycbi4u	363	3	coworkers	coworker	NNS
cord-300872-blycbi4u	363	4	prepared	prepare	VBD
cord-300872-blycbi4u	363	5	a	a	DT
cord-300872-blycbi4u	363	6	novel	novel	JJ
cord-300872-blycbi4u	363	7	compound	compound	NN
cord-300872-blycbi4u	363	8	(	(	-LRB-
cord-300872-blycbi4u	363	9	Figure	figure	NN
cord-300872-blycbi4u	363	10	4	4	CD
cord-300872-blycbi4u	363	11	)	)	-RRB-
cord-300872-blycbi4u	363	12	bearing	bear	VBG
cord-300872-blycbi4u	363	13	three	three	CD
cord-300872-blycbi4u	363	14	quinolinone	quinolinone	NNP
cord-300872-blycbi4u	363	15	moieties	moiety	NNS
cord-300872-blycbi4u	363	16	in	in	IN
cord-300872-blycbi4u	363	17	a	a	DT
cord-300872-blycbi4u	363	18	simple	simple	JJ
cord-300872-blycbi4u	363	19	procedure	procedure	NN
cord-300872-blycbi4u	363	20	that	that	WDT
cord-300872-blycbi4u	363	21	involved	involve	VBD
cord-300872-blycbi4u	363	22	a	a	DT
cord-300872-blycbi4u	363	23	reaction	reaction	NN
cord-300872-blycbi4u	363	24	of	of	IN
cord-300872-blycbi4u	363	25	3,6-bis(bromomethyl)-2-chloroquinoline	3,6-bis(bromomethyl)-2-chloroquinoline	CD
cord-300872-blycbi4u	363	26	and	and	CC
cord-300872-blycbi4u	363	27	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	363	28	at	at	IN
cord-300872-blycbi4u	363	29	a	a	DT
cord-300872-blycbi4u	363	30	ratio	ratio	NN
cord-300872-blycbi4u	363	31	of	of	IN
cord-300872-blycbi4u	363	32	1:2	1:2	CD
cord-300872-blycbi4u	363	33	in	in	IN
cord-300872-blycbi4u	363	34	acetone	acetone	NN
cord-300872-blycbi4u	363	35	(	(	-LRB-
cord-300872-blycbi4u	363	36	aprotic	aprotic	JJ
cord-300872-blycbi4u	363	37	polar	polar	JJ
cord-300872-blycbi4u	363	38	solvent	solvent	NN
cord-300872-blycbi4u	363	39	)	)	-RRB-
cord-300872-blycbi4u	363	40	under	under	IN
cord-300872-blycbi4u	363	41	reflux	reflux	NN
cord-300872-blycbi4u	363	42	conditions	condition	NNS
cord-300872-blycbi4u	363	43	.	.	.
cord-300872-blycbi4u	364	1	The	the	DT
cord-300872-blycbi4u	364	2	target	target	NN
cord-300872-blycbi4u	364	3	product	product	NN
cord-300872-blycbi4u	364	4	was	be	VBD
cord-300872-blycbi4u	364	5	fully	fully	RB
cord-300872-blycbi4u	364	6	characterized	characterize	VBN
cord-300872-blycbi4u	364	7	by	by	IN
cord-300872-blycbi4u	364	8	using	use	VBG
cord-300872-blycbi4u	364	9	various	various	JJ
cord-300872-blycbi4u	364	10	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	364	11	techniques	technique	NNS
cord-300872-blycbi4u	364	12	and	and	CC
cord-300872-blycbi4u	364	13	singlecrystal	singlecrystal	NNP
cord-300872-blycbi4u	364	14	X	x	NN
cord-300872-blycbi4u	364	15	-	-	NN
cord-300872-blycbi4u	364	16	ray	ray	NN
cord-300872-blycbi4u	364	17	diffraction	diffraction	NN
cord-300872-blycbi4u	364	18	method	method	NN
cord-300872-blycbi4u	364	19	.	.	.
cord-300872-blycbi4u	365	1	This	this	DT
cord-300872-blycbi4u	365	2	compound	compound	NN
cord-300872-blycbi4u	365	3	was	be	VBD
cord-300872-blycbi4u	365	4	screened	screen	VBN
cord-300872-blycbi4u	365	5	against	against	IN
cord-300872-blycbi4u	365	6	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	365	7	and	and	CC
cord-300872-blycbi4u	365	8	Hela	Hela	NNP
cord-300872-blycbi4u	365	9	cancer	cancer	NN
cord-300872-blycbi4u	365	10	cell	cell	NN
cord-300872-blycbi4u	366	1	In	in	IN
cord-300872-blycbi4u	366	2	addition	addition	NN
cord-300872-blycbi4u	366	3	,	,	,
cord-300872-blycbi4u	366	4	Shamsi	Shamsi	NNP
cord-300872-blycbi4u	366	5	and	and	CC
cord-300872-blycbi4u	366	6	coworkers	coworker	NNS
cord-300872-blycbi4u	366	7	prepared	prepare	VBD
cord-300872-blycbi4u	366	8	16	16	CD
cord-300872-blycbi4u	366	9	quinoline	quinoline	NN
cord-300872-blycbi4u	366	10	-	-	HYPH
cord-300872-blycbi4u	366	11	based	base	VBN
cord-300872-blycbi4u	366	12	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	366	13	-	-	HYPH
cord-300872-blycbi4u	366	14	triazole	triazole	NN
cord-300872-blycbi4u	366	15	derivatives	derivative	NNS
cord-300872-blycbi4u	366	16	(	(	-LRB-
cord-300872-blycbi4u	366	17	Scheme	scheme	NN
cord-300872-blycbi4u	366	18	14	14	CD
cord-300872-blycbi4u	366	19	)	)	-RRB-
cord-300872-blycbi4u	366	20	based	base	VBN
cord-300872-blycbi4u	366	21	on	on	IN
cord-300872-blycbi4u	366	22	the	the	DT
cord-300872-blycbi4u	366	23	hybrid	hybrid	JJ
cord-300872-blycbi4u	366	24	strategy	strategy	NN
cord-300872-blycbi4u	366	25	of	of	IN
cord-300872-blycbi4u	366	26	nitrogen	nitrogen	NN
cord-300872-blycbi4u	366	27	-	-	HYPH
cord-300872-blycbi4u	366	28	containing	contain	VBG
cord-300872-blycbi4u	366	29	heterocyclic	heterocyclic	JJ
cord-300872-blycbi4u	366	30	scaffolds	scaffold	NNS
cord-300872-blycbi4u	366	31	[	[	-LRB-
cord-300872-blycbi4u	366	32	36	36	CD
cord-300872-blycbi4u	366	33	]	]	-RRB-
cord-300872-blycbi4u	366	34	.	.	.
cord-300872-blycbi4u	367	1	These	these	DT
cord-300872-blycbi4u	367	2	compounds	compound	NNS
cord-300872-blycbi4u	367	3	were	be	VBD
cord-300872-blycbi4u	367	4	considered	consider	VBN
cord-300872-blycbi4u	367	5	to	to	TO
cord-300872-blycbi4u	367	6	be	be	VB
cord-300872-blycbi4u	367	7	high	high	JJ
cord-300872-blycbi4u	367	8	-	-	HYPH
cord-300872-blycbi4u	367	9	impact	impact	NN
cord-300872-blycbi4u	367	10	motifs	motif	NNS
cord-300872-blycbi4u	367	11	with	with	IN
cord-300872-blycbi4u	367	12	a	a	DT
cord-300872-blycbi4u	367	13	wide	wide	JJ
cord-300872-blycbi4u	367	14	range	range	NN
cord-300872-blycbi4u	367	15	of	of	IN
cord-300872-blycbi4u	367	16	biological	biological	JJ
cord-300872-blycbi4u	367	17	activities	activity	NNS
cord-300872-blycbi4u	367	18	[	[	-LRB-
cord-300872-blycbi4u	367	19	37	37	CD
cord-300872-blycbi4u	367	20	,	,	,
cord-300872-blycbi4u	367	21	38	38	CD
cord-300872-blycbi4u	367	22	]	]	-RRB-
cord-300872-blycbi4u	367	23	.	.	.
cord-300872-blycbi4u	368	1	The	the	DT
cord-300872-blycbi4u	368	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	368	3	strategy	strategy	NN
cord-300872-blycbi4u	368	4	was	be	VBD
cord-300872-blycbi4u	368	5	based	base	VBN
cord-300872-blycbi4u	368	6	on	on	IN
cord-300872-blycbi4u	368	7	the	the	DT
cord-300872-blycbi4u	368	8	treatment	treatment	NN
cord-300872-blycbi4u	368	9	of	of	IN
cord-300872-blycbi4u	368	10	1	1	CD
cord-300872-blycbi4u	368	11	with	with	IN
cord-300872-blycbi4u	368	12	carbonate	carbonate	NN
cord-300872-blycbi4u	368	13	to	to	TO
cord-300872-blycbi4u	368	14	produce	produce	VB
cord-300872-blycbi4u	368	15	the	the	DT
cord-300872-blycbi4u	368	16	phenolate	phenolate	NN
cord-300872-blycbi4u	368	17	anion	anion	NN
cord-300872-blycbi4u	368	18	,	,	,
cord-300872-blycbi4u	368	19	which	which	WDT
cord-300872-blycbi4u	368	20	reacts	react	VBZ
cord-300872-blycbi4u	368	21	with	with	IN
cord-300872-blycbi4u	368	22	ethyl	ethyl	NN
cord-300872-blycbi4u	368	23	chloroacetate	chloroacetate	NNP
cord-300872-blycbi4u	368	24	under	under	IN
cord-300872-blycbi4u	368	25	SN2	sn2	JJ
cord-300872-blycbi4u	368	26	conditions	condition	NNS
cord-300872-blycbi4u	368	27	to	to	TO
cord-300872-blycbi4u	368	28	afford	afford	VB
cord-300872-blycbi4u	368	29	the	the	DT
cord-300872-blycbi4u	368	30	corresponding	correspond	VBG
cord-300872-blycbi4u	368	31	intermediate	intermediate	NN
cord-300872-blycbi4u	368	32	.	.	.
cord-300872-blycbi4u	369	1	Reaction	reaction	NN
cord-300872-blycbi4u	369	2	of	of	IN
cord-300872-blycbi4u	369	3	this	this	DT
cord-300872-blycbi4u	369	4	intermediate	intermediate	JJ
cord-300872-blycbi4u	369	5	with	with	IN
cord-300872-blycbi4u	369	6	hydrazine	hydrazine	NN
cord-300872-blycbi4u	369	7	produced	produce	VBN
cord-300872-blycbi4u	369	8	54	54	CD
cord-300872-blycbi4u	369	9	,	,	,
cord-300872-blycbi4u	369	10	which	which	WDT
cord-300872-blycbi4u	369	11	undergoes	undergo	VBZ
cord-300872-blycbi4u	369	12	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	369	13	cyclization	cyclization	NN
cord-300872-blycbi4u	369	14	in	in	IN
cord-300872-blycbi4u	369	15	the	the	DT
cord-300872-blycbi4u	369	16	presence	presence	NN
cord-300872-blycbi4u	369	17	of	of	IN
cord-300872-blycbi4u	369	18	carbon	carbon	NN
cord-300872-blycbi4u	369	19	disulfide	disulfide	NN
cord-300872-blycbi4u	369	20	and	and	CC
cord-300872-blycbi4u	369	21	the	the	DT
cord-300872-blycbi4u	369	22	base	base	NN
cord-300872-blycbi4u	369	23	(	(	-LRB-
cord-300872-blycbi4u	369	24	KOH	KOH	NNP
cord-300872-blycbi4u	369	25	)	)	-RRB-
cord-300872-blycbi4u	369	26	to	to	TO
cord-300872-blycbi4u	369	27	give	give	VB
cord-300872-blycbi4u	369	28	compound	compound	NN
cord-300872-blycbi4u	369	29	55	55	CD
cord-300872-blycbi4u	369	30	(	(	-LRB-
cord-300872-blycbi4u	369	31	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	369	32	)	)	-RRB-
cord-300872-blycbi4u	369	33	after	after	IN
cord-300872-blycbi4u	369	34	acidification	acidification	NN
cord-300872-blycbi4u	369	35	.	.	.
cord-300872-blycbi4u	370	1	The	the	DT
cord-300872-blycbi4u	370	2	thiol	thiol	NN
cord-300872-blycbi4u	370	3	group	group	NN
cord-300872-blycbi4u	370	4	(	(	-LRB-
cord-300872-blycbi4u	370	5	Ar	Ar	NNP
cord-300872-blycbi4u	370	6	-	-	HYPH
cord-300872-blycbi4u	370	7	SH	SH	NNP
cord-300872-blycbi4u	370	8	)	)	-RRB-
cord-300872-blycbi4u	370	9	in	in	IN
cord-300872-blycbi4u	370	10	55	55	CD
cord-300872-blycbi4u	370	11	is	be	VBZ
cord-300872-blycbi4u	370	12	acidic	acidic	JJ
cord-300872-blycbi4u	370	13	and	and	CC
cord-300872-blycbi4u	370	14	gives	give	VBZ
cord-300872-blycbi4u	370	15	the	the	DT
cord-300872-blycbi4u	370	16	Ar	Ar	NNP
cord-300872-blycbi4u	370	17	-	-	HYPH
cord-300872-blycbi4u	370	18	Sanion	Sanion	NNP
cord-300872-blycbi4u	370	19	upon	upon	IN
cord-300872-blycbi4u	370	20	treatment	treatment	NN
cord-300872-blycbi4u	370	21	with	with	IN
cord-300872-blycbi4u	370	22	a	a	DT
cord-300872-blycbi4u	370	23	base	base	NN
cord-300872-blycbi4u	370	24	.	.	.
cord-300872-blycbi4u	371	1	Then	then	RB
cord-300872-blycbi4u	371	2	,	,	,
cord-300872-blycbi4u	371	3	the	the	DT
cord-300872-blycbi4u	371	4	corresponding	corresponding	JJ
cord-300872-blycbi4u	371	5	anion	anion	NN
cord-300872-blycbi4u	371	6	reacts	react	VBZ
cord-300872-blycbi4u	371	7	with	with	IN
cord-300872-blycbi4u	371	8	propargyl	propargyl	NNS
cord-300872-blycbi4u	371	9	bromide	bromide	NN
cord-300872-blycbi4u	371	10	to	to	TO
cord-300872-blycbi4u	371	11	afford	afford	VB
cord-300872-blycbi4u	371	12	compound	compound	NN
cord-300872-blycbi4u	371	13	56	56	CD
cord-300872-blycbi4u	371	14	.	.	.
cord-300872-blycbi4u	372	1	Finally	finally	RB
cord-300872-blycbi4u	372	2	,	,	,
cord-300872-blycbi4u	372	3	reaction	reaction	NN
cord-300872-blycbi4u	372	4	of	of	IN
cord-300872-blycbi4u	372	5	various	various	JJ
cord-300872-blycbi4u	372	6	azide	azide	NN
cord-300872-blycbi4u	372	7	derivatives	derivative	NNS
cord-300872-blycbi4u	372	8	of	of	IN
cord-300872-blycbi4u	372	9	56	56	CD
cord-300872-blycbi4u	372	10	yielded	yield	VBD
cord-300872-blycbi4u	372	11	the	the	DT
cord-300872-blycbi4u	372	12	target	target	NN
cord-300872-blycbi4u	372	13	derivative	derivative	JJ
cord-300872-blycbi4u	372	14	57	57	CD
cord-300872-blycbi4u	372	15	through	through	IN
cord-300872-blycbi4u	372	16	a	a	DT
cord-300872-blycbi4u	372	17	(	(	-LRB-
cord-300872-blycbi4u	372	18	3	3	CD
cord-300872-blycbi4u	372	19	+	+	SYM
cord-300872-blycbi4u	372	20	2	2	CD
cord-300872-blycbi4u	372	21	)	)	-RRB-
cord-300872-blycbi4u	372	22	cycloaddition	cycloaddition	NN
cord-300872-blycbi4u	372	23	mechanism	mechanism	NN
cord-300872-blycbi4u	372	24	.	.	.
cord-300872-blycbi4u	373	1	Scheme	scheme	NN
cord-300872-blycbi4u	373	2	13	13	CD
cord-300872-blycbi4u	373	3	.	.	.
cord-300872-blycbi4u	374	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	374	2	of	of	IN
cord-300872-blycbi4u	374	3	novel	novel	JJ
cord-300872-blycbi4u	374	4	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	374	5	-	-	HYPH
cord-300872-blycbi4u	374	6	quinoline	quinoline	NN
cord-300872-blycbi4u	374	7	derivatives	derivative	NNS
cord-300872-blycbi4u	374	8	.	.	.
cord-300872-blycbi4u	375	1	Gayathri	Gayathri	NNP
cord-300872-blycbi4u	375	2	and	and	CC
cord-300872-blycbi4u	375	3	coworkers	coworker	NNS
cord-300872-blycbi4u	375	4	prepared	prepare	VBD
cord-300872-blycbi4u	375	5	a	a	DT
cord-300872-blycbi4u	375	6	novel	novel	JJ
cord-300872-blycbi4u	375	7	compound	compound	NN
cord-300872-blycbi4u	375	8	(	(	-LRB-
cord-300872-blycbi4u	375	9	Figure	figure	NN
cord-300872-blycbi4u	375	10	4	4	CD
cord-300872-blycbi4u	375	11	)	)	-RRB-
cord-300872-blycbi4u	375	12	bearing	bear	VBG
cord-300872-blycbi4u	375	13	three	three	CD
cord-300872-blycbi4u	375	14	quinolinone	quinolinone	NNP
cord-300872-blycbi4u	375	15	moieties	moiety	NNS
cord-300872-blycbi4u	375	16	in	in	IN
cord-300872-blycbi4u	375	17	a	a	DT
cord-300872-blycbi4u	375	18	simple	simple	JJ
cord-300872-blycbi4u	375	19	procedure	procedure	NN
cord-300872-blycbi4u	375	20	that	that	WDT
cord-300872-blycbi4u	375	21	involved	involve	VBD
cord-300872-blycbi4u	375	22	a	a	DT
cord-300872-blycbi4u	375	23	reaction	reaction	NN
cord-300872-blycbi4u	375	24	of	of	IN
cord-300872-blycbi4u	375	25	3,6-bis(bromomethyl)-2-chloroquinoline	3,6-bis(bromomethyl)-2-chloroquinoline	CD
cord-300872-blycbi4u	375	26	and	and	CC
cord-300872-blycbi4u	375	27	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	375	28	at	at	IN
cord-300872-blycbi4u	375	29	a	a	DT
cord-300872-blycbi4u	375	30	ratio	ratio	NN
cord-300872-blycbi4u	375	31	of	of	IN
cord-300872-blycbi4u	375	32	1:2	1:2	CD
cord-300872-blycbi4u	375	33	in	in	IN
cord-300872-blycbi4u	375	34	acetone	acetone	NN
cord-300872-blycbi4u	375	35	(	(	-LRB-
cord-300872-blycbi4u	375	36	aprotic	aprotic	JJ
cord-300872-blycbi4u	375	37	polar	polar	JJ
cord-300872-blycbi4u	375	38	solvent	solvent	NN
cord-300872-blycbi4u	375	39	)	)	-RRB-
cord-300872-blycbi4u	375	40	under	under	IN
cord-300872-blycbi4u	375	41	reflux	reflux	NN
cord-300872-blycbi4u	375	42	conditions	condition	NNS
cord-300872-blycbi4u	375	43	.	.	.
cord-300872-blycbi4u	376	1	The	the	DT
cord-300872-blycbi4u	376	2	target	target	NN
cord-300872-blycbi4u	376	3	product	product	NN
cord-300872-blycbi4u	376	4	was	be	VBD
cord-300872-blycbi4u	376	5	fully	fully	RB
cord-300872-blycbi4u	376	6	characterized	characterize	VBN
cord-300872-blycbi4u	376	7	by	by	IN
cord-300872-blycbi4u	376	8	using	use	VBG
cord-300872-blycbi4u	376	9	various	various	JJ
cord-300872-blycbi4u	376	10	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	376	11	techniques	technique	NNS
cord-300872-blycbi4u	376	12	and	and	CC
cord-300872-blycbi4u	376	13	single	single	JJ
cord-300872-blycbi4u	376	14	-	-	HYPH
cord-300872-blycbi4u	376	15	crystal	crystal	NN
cord-300872-blycbi4u	376	16	X	x	NN
cord-300872-blycbi4u	376	17	-	-	NN
cord-300872-blycbi4u	376	18	ray	ray	NN
cord-300872-blycbi4u	376	19	diffraction	diffraction	NN
cord-300872-blycbi4u	376	20	method	method	NN
cord-300872-blycbi4u	376	21	.	.	.
cord-300872-blycbi4u	377	1	This	this	DT
cord-300872-blycbi4u	377	2	compound	compound	NN
cord-300872-blycbi4u	377	3	was	be	VBD
cord-300872-blycbi4u	377	4	screened	screen	VBN
cord-300872-blycbi4u	377	5	against	against	IN
cord-300872-blycbi4u	377	6	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	377	7	and	and	CC
cord-300872-blycbi4u	377	8	Hela	Hela	NNP
cord-300872-blycbi4u	377	9	cancer	cancer	NN
cord-300872-blycbi4u	377	10	cell	cell	NN
cord-300872-blycbi4u	377	11	lines	line	NNS
cord-300872-blycbi4u	377	12	using	use	VBG
cord-300872-blycbi4u	377	13	MMT	MMT	NNP
cord-300872-blycbi4u	377	14	assay	assay	NN
cord-300872-blycbi4u	377	15	,	,	,
cord-300872-blycbi4u	377	16	giving	give	VBG
cord-300872-blycbi4u	377	17	IC	IC	NNP
cord-300872-blycbi4u	377	18	50	50	CD
cord-300872-blycbi4u	377	19	values	value	NNS
cord-300872-blycbi4u	377	20	of	of	IN
cord-300872-blycbi4u	377	21	21.02	21.02	CD
cord-300872-blycbi4u	377	22	and	and	CC
cord-300872-blycbi4u	377	23	27.73	27.73	CD
cord-300872-blycbi4u	377	24	mM	mm	CD
cord-300872-blycbi4u	377	25	,	,	,
cord-300872-blycbi4u	377	26	respectively	respectively	RB
cord-300872-blycbi4u	377	27	[	[	-LRB-
cord-300872-blycbi4u	377	28	35	35	CD
cord-300872-blycbi4u	377	29	]	]	-RRB-
cord-300872-blycbi4u	377	30	.	.	.
cord-300872-blycbi4u	378	1	Molecules	molecule	NNS
cord-300872-blycbi4u	378	2	2020	2020	CD
cord-300872-blycbi4u	378	3	,	,	,
cord-300872-blycbi4u	378	4	25	25	CD
cord-300872-blycbi4u	378	5	,	,	,
cord-300872-blycbi4u	378	6	x	x	NN
cord-300872-blycbi4u	378	7	FOR	for	IN
cord-300872-blycbi4u	378	8	PEER	PEER	NNP
cord-300872-blycbi4u	378	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	378	10	12	12	CD
cord-300872-blycbi4u	378	11	of	of	IN
cord-300872-blycbi4u	378	12	26	26	CD
cord-300872-blycbi4u	378	13	microwave	microwave	NN
cord-300872-blycbi4u	378	14	approach	approach	NN
cord-300872-blycbi4u	378	15	to	to	TO
cord-300872-blycbi4u	378	16	form	form	VB
cord-300872-blycbi4u	378	17	the	the	DT
cord-300872-blycbi4u	378	18	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	378	19	(	(	-LRB-
cord-300872-blycbi4u	378	20	51	51	CD
cord-300872-blycbi4u	378	21	)	)	-RRB-
cord-300872-blycbi4u	378	22	.	.	.
cord-300872-blycbi4u	379	1	The	the	DT
cord-300872-blycbi4u	379	2	reaction	reaction	NN
cord-300872-blycbi4u	379	3	between	between	IN
cord-300872-blycbi4u	379	4	51	51	CD
cord-300872-blycbi4u	379	5	and	and	CC
cord-300872-blycbi4u	379	6	5,7-dialkyl-8hydroxyquinoline	5,7-dialkyl-8hydroxyquinoline	CD
cord-300872-blycbi4u	379	7	as	as	IN
cord-300872-blycbi4u	379	8	a	a	DT
cord-300872-blycbi4u	379	9	phenolate	phenolate	NN
cord-300872-blycbi4u	379	10	ion	ion	NN
cord-300872-blycbi4u	379	11	in	in	IN
cord-300872-blycbi4u	379	12	the	the	DT
cord-300872-blycbi4u	379	13	presence	presence	NN
cord-300872-blycbi4u	379	14	of	of	IN
cord-300872-blycbi4u	379	15	a	a	DT
cord-300872-blycbi4u	379	16	catalytic	catalytic	JJ
cord-300872-blycbi4u	379	17	amount	amount	NN
cord-300872-blycbi4u	379	18	of	of	IN
cord-300872-blycbi4u	379	19	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	379	20	IRA	IRA	NNP
cord-300872-blycbi4u	379	21	and	and	CC
cord-300872-blycbi4u	379	22	an	an	DT
cord-300872-blycbi4u	379	23	excess	excess	JJ
cord-300872-blycbi4u	379	24	amount	amount	NN
cord-300872-blycbi4u	379	25	of	of	IN
cord-300872-blycbi4u	379	26	dibromoalkane	dibromoalkane	NN
cord-300872-blycbi4u	379	27	under	under	IN
cord-300872-blycbi4u	379	28	microwave	microwave	NN
cord-300872-blycbi4u	379	29	conditions	condition	NNS
cord-300872-blycbi4u	379	30	afforded	afford	VBD
cord-300872-blycbi4u	379	31	the	the	DT
cord-300872-blycbi4u	379	32	target	target	NN
cord-300872-blycbi4u	379	33	product	product	NN
cord-300872-blycbi4u	379	34	52	52	CD
cord-300872-blycbi4u	379	35	;	;	:
cord-300872-blycbi4u	379	36	dibromoalkanes	dibromoalkane	NNS
cord-300872-blycbi4u	379	37	were	be	VBD
cord-300872-blycbi4u	379	38	employed	employ	VBN
cord-300872-blycbi4u	379	39	as	as	IN
cord-300872-blycbi4u	379	40	linkers	linker	NNS
cord-300872-blycbi4u	379	41	between	between	IN
cord-300872-blycbi4u	379	42	the	the	DT
cord-300872-blycbi4u	379	43	two	two	CD
cord-300872-blycbi4u	379	44	fragments	fragment	NNS
cord-300872-blycbi4u	379	45	,	,	,
cord-300872-blycbi4u	379	46	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	379	47	and	and	CC
cord-300872-blycbi4u	379	48	2benzothiazol-2-ylphenol	2benzothiazol-2-ylphenol	CD
cord-300872-blycbi4u	379	49	.	.	.
cord-300872-blycbi4u	380	1	The	the	DT
cord-300872-blycbi4u	380	2	prepared	prepared	JJ
cord-300872-blycbi4u	380	3	compounds	compound	NNS
cord-300872-blycbi4u	380	4	were	be	VBD
cord-300872-blycbi4u	380	5	then	then	RB
cord-300872-blycbi4u	380	6	subjected	subject	VBN
cord-300872-blycbi4u	380	7	to	to	IN
cord-300872-blycbi4u	380	8	a	a	DT
cord-300872-blycbi4u	380	9	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	380	10	study	study	NN
cord-300872-blycbi4u	380	11	along	along	IN
cord-300872-blycbi4u	380	12	with	with	IN
cord-300872-blycbi4u	380	13	cisplatin	cisplatin	NN
cord-300872-blycbi4u	380	14	(	(	-LRB-
cord-300872-blycbi4u	380	15	a	a	DT
cord-300872-blycbi4u	380	16	positive	positive	JJ
cord-300872-blycbi4u	380	17	control	control	NN
cord-300872-blycbi4u	380	18	)	)	-RRB-
cord-300872-blycbi4u	380	19	against	against	IN
cord-300872-blycbi4u	380	20	a	a	DT
cord-300872-blycbi4u	380	21	panel	panel	NN
cord-300872-blycbi4u	380	22	of	of	IN
cord-300872-blycbi4u	380	23	cancer	cancer	NN
cord-300872-blycbi4u	380	24	cell	cell	NN
cord-300872-blycbi4u	380	25	lines	line	NNS
cord-300872-blycbi4u	380	26	,	,	,
cord-300872-blycbi4u	380	27	including	include	VBG
cord-300872-blycbi4u	380	28	HeLa	HeLa	NNP
cord-300872-blycbi4u	380	29	,	,	,
cord-300872-blycbi4u	380	30	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	380	31	,	,	,
cord-300872-blycbi4u	380	32	A549	a549	JJ
cord-300872-blycbi4u	380	33	,	,	,
cord-300872-blycbi4u	380	34	and	and	CC
cord-300872-blycbi4u	380	35	human	human	JJ
cord-300872-blycbi4u	380	36	ovarian	ovarian	JJ
cord-300872-blycbi4u	380	37	carcinoma	carcinoma	NN
cord-300872-blycbi4u	380	38	(	(	-LRB-
cord-300872-blycbi4u	380	39	A2780	A2780	NNP
cord-300872-blycbi4u	380	40	)	)	-RRB-
cord-300872-blycbi4u	380	41	,	,	,
cord-300872-blycbi4u	380	42	using	use	VBG
cord-300872-blycbi4u	380	43	the	the	DT
cord-300872-blycbi4u	380	44	MMT	MMT	NNP
cord-300872-blycbi4u	380	45	assay	assay	NN
cord-300872-blycbi4u	380	46	.	.	.
cord-300872-blycbi4u	381	1	Most	Most	JJS
cord-300872-blycbi4u	381	2	of	of	IN
cord-300872-blycbi4u	381	3	the	the	DT
cord-300872-blycbi4u	381	4	prepared	prepared	JJ
cord-300872-blycbi4u	381	5	compounds	compound	NNS
cord-300872-blycbi4u	381	6	were	be	VBD
cord-300872-blycbi4u	381	7	more	more	RBR
cord-300872-blycbi4u	381	8	potent	potent	JJ
cord-300872-blycbi4u	381	9	than	than	IN
cord-300872-blycbi4u	381	10	cisplatin	cisplatin	NN
cord-300872-blycbi4u	381	11	,	,	,
cord-300872-blycbi4u	381	12	with	with	IN
cord-300872-blycbi4u	381	13	IC50	ic50	JJ
cord-300872-blycbi4u	381	14	values	value	NNS
cord-300872-blycbi4u	381	15	in	in	IN
cord-300872-blycbi4u	381	16	the	the	DT
cord-300872-blycbi4u	381	17	ranges	range	NNS
cord-300872-blycbi4u	381	18	of	of	IN
cord-300872-blycbi4u	381	19	5	5	CD
cord-300872-blycbi4u	381	20	-	-	SYM
cord-300872-blycbi4u	381	21	19	19	CD
cord-300872-blycbi4u	381	22	,	,	,
cord-300872-blycbi4u	381	23	7	7	CD
cord-300872-blycbi4u	381	24	-	-	SYM
cord-300872-blycbi4u	381	25	49	49	CD
cord-300872-blycbi4u	381	26	,	,	,
cord-300872-blycbi4u	381	27	10	10	CD
cord-300872-blycbi4u	381	28	-	-	SYM
cord-300872-blycbi4u	381	29	30	30	CD
cord-300872-blycbi4u	381	30	,	,	,
cord-300872-blycbi4u	381	31	and	and	CC
cord-300872-blycbi4u	381	32	10	10	CD
cord-300872-blycbi4u	381	33	-	-	SYM
cord-300872-blycbi4u	381	34	38	38	CD
cord-300872-blycbi4u	381	35	mM	mm	NN
cord-300872-blycbi4u	381	36	against	against	IN
cord-300872-blycbi4u	381	37	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	381	38	,	,	,
cord-300872-blycbi4u	381	39	HeLa	HeLa	NNP
cord-300872-blycbi4u	381	40	cells	cell	NNS
cord-300872-blycbi4u	381	41	,	,	,
cord-300872-blycbi4u	381	42	A2780	A2780	NNP
cord-300872-blycbi4u	381	43	,	,	,
cord-300872-blycbi4u	381	44	and	and	CC
cord-300872-blycbi4u	381	45	A549	A549	NNPS
cord-300872-blycbi4u	381	46	,	,	,
cord-300872-blycbi4u	381	47	respectively	respectively	RB
cord-300872-blycbi4u	381	48	.	.	.
cord-300872-blycbi4u	382	1	In	in	IN
cord-300872-blycbi4u	382	2	addition	addition	NN
cord-300872-blycbi4u	382	3	,	,	,
cord-300872-blycbi4u	382	4	the	the	DT
cord-300872-blycbi4u	382	5	target	target	NN
cord-300872-blycbi4u	382	6	products	product	NNS
cord-300872-blycbi4u	382	7	were	be	VBD
cord-300872-blycbi4u	382	8	3	3	CD
cord-300872-blycbi4u	382	9	-	-	SYM
cord-300872-blycbi4u	382	10	25-fold	25-fold	JJ
cord-300872-blycbi4u	382	11	more	more	RBR
cord-300872-blycbi4u	382	12	selective	selective	JJ
cord-300872-blycbi4u	382	13	in	in	IN
cord-300872-blycbi4u	382	14	cancer	cancer	NN
cord-300872-blycbi4u	382	15	cell	cell	NN
cord-300872-blycbi4u	382	16	lines	line	NNS
cord-300872-blycbi4u	382	17	than	than	IN
cord-300872-blycbi4u	382	18	normal	normal	JJ
cord-300872-blycbi4u	382	19	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	382	20	.	.	.
cord-300872-blycbi4u	383	1	Gayathri	Gayathri	NNP
cord-300872-blycbi4u	383	2	and	and	CC
cord-300872-blycbi4u	383	3	coworkers	coworker	NNS
cord-300872-blycbi4u	383	4	prepared	prepare	VBD
cord-300872-blycbi4u	383	5	a	a	DT
cord-300872-blycbi4u	383	6	novel	novel	JJ
cord-300872-blycbi4u	383	7	compound	compound	NN
cord-300872-blycbi4u	383	8	(	(	-LRB-
cord-300872-blycbi4u	383	9	Figure	figure	NN
cord-300872-blycbi4u	383	10	4	4	CD
cord-300872-blycbi4u	383	11	)	)	-RRB-
cord-300872-blycbi4u	383	12	bearing	bear	VBG
cord-300872-blycbi4u	383	13	three	three	CD
cord-300872-blycbi4u	383	14	quinolinone	quinolinone	NNP
cord-300872-blycbi4u	383	15	moieties	moiety	NNS
cord-300872-blycbi4u	383	16	in	in	IN
cord-300872-blycbi4u	383	17	a	a	DT
cord-300872-blycbi4u	383	18	simple	simple	JJ
cord-300872-blycbi4u	383	19	procedure	procedure	NN
cord-300872-blycbi4u	383	20	that	that	WDT
cord-300872-blycbi4u	383	21	involved	involve	VBD
cord-300872-blycbi4u	383	22	a	a	DT
cord-300872-blycbi4u	383	23	reaction	reaction	NN
cord-300872-blycbi4u	383	24	of	of	IN
cord-300872-blycbi4u	383	25	3,6-bis(bromomethyl)-2-chloroquinoline	3,6-bis(bromomethyl)-2-chloroquinoline	CD
cord-300872-blycbi4u	383	26	and	and	CC
cord-300872-blycbi4u	383	27	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	383	28	at	at	IN
cord-300872-blycbi4u	383	29	a	a	DT
cord-300872-blycbi4u	383	30	ratio	ratio	NN
cord-300872-blycbi4u	383	31	of	of	IN
cord-300872-blycbi4u	383	32	1:2	1:2	CD
cord-300872-blycbi4u	383	33	in	in	IN
cord-300872-blycbi4u	383	34	acetone	acetone	NN
cord-300872-blycbi4u	383	35	(	(	-LRB-
cord-300872-blycbi4u	383	36	aprotic	aprotic	JJ
cord-300872-blycbi4u	383	37	polar	polar	JJ
cord-300872-blycbi4u	383	38	solvent	solvent	NN
cord-300872-blycbi4u	383	39	)	)	-RRB-
cord-300872-blycbi4u	383	40	under	under	IN
cord-300872-blycbi4u	383	41	reflux	reflux	NN
cord-300872-blycbi4u	383	42	conditions	condition	NNS
cord-300872-blycbi4u	383	43	.	.	.
cord-300872-blycbi4u	384	1	The	the	DT
cord-300872-blycbi4u	384	2	target	target	NN
cord-300872-blycbi4u	384	3	product	product	NN
cord-300872-blycbi4u	384	4	was	be	VBD
cord-300872-blycbi4u	384	5	fully	fully	RB
cord-300872-blycbi4u	384	6	characterized	characterize	VBN
cord-300872-blycbi4u	384	7	by	by	IN
cord-300872-blycbi4u	384	8	using	use	VBG
cord-300872-blycbi4u	384	9	various	various	JJ
cord-300872-blycbi4u	384	10	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	384	11	techniques	technique	NNS
cord-300872-blycbi4u	384	12	and	and	CC
cord-300872-blycbi4u	384	13	singlecrystal	singlecrystal	NNP
cord-300872-blycbi4u	384	14	X	x	NN
cord-300872-blycbi4u	384	15	-	-	NN
cord-300872-blycbi4u	384	16	ray	ray	NN
cord-300872-blycbi4u	384	17	diffraction	diffraction	NN
cord-300872-blycbi4u	384	18	method	method	NN
cord-300872-blycbi4u	384	19	.	.	.
cord-300872-blycbi4u	385	1	This	this	DT
cord-300872-blycbi4u	385	2	compound	compound	NN
cord-300872-blycbi4u	385	3	was	be	VBD
cord-300872-blycbi4u	385	4	screened	screen	VBN
cord-300872-blycbi4u	385	5	against	against	IN
cord-300872-blycbi4u	385	6	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	385	7	and	and	CC
cord-300872-blycbi4u	385	8	Hela	Hela	NNP
cord-300872-blycbi4u	385	9	cancer	cancer	NN
cord-300872-blycbi4u	385	10	cell	cell	NN
cord-300872-blycbi4u	385	11	lines	line	NNS
cord-300872-blycbi4u	385	12	using	use	VBG
cord-300872-blycbi4u	385	13	MMT	MMT	NNP
cord-300872-blycbi4u	385	14	assay	assay	NN
cord-300872-blycbi4u	385	15	,	,	,
cord-300872-blycbi4u	385	16	giving	give	VBG
cord-300872-blycbi4u	385	17	IC50	ic50	JJ
cord-300872-blycbi4u	385	18	values	value	NNS
cord-300872-blycbi4u	385	19	of	of	IN
cord-300872-blycbi4u	385	20	21.02	21.02	CD
cord-300872-blycbi4u	385	21	and	and	CC
cord-300872-blycbi4u	385	22	27.73	27.73	CD
cord-300872-blycbi4u	385	23	mM	mm	CD
cord-300872-blycbi4u	385	24	,	,	,
cord-300872-blycbi4u	385	25	respectively	respectively	RB
cord-300872-blycbi4u	386	1	In	in	IN
cord-300872-blycbi4u	386	2	addition	addition	NN
cord-300872-blycbi4u	386	3	,	,	,
cord-300872-blycbi4u	386	4	Shamsi	Shamsi	NNP
cord-300872-blycbi4u	386	5	and	and	CC
cord-300872-blycbi4u	386	6	coworkers	coworker	NNS
cord-300872-blycbi4u	386	7	prepared	prepare	VBD
cord-300872-blycbi4u	386	8	16	16	CD
cord-300872-blycbi4u	386	9	quinoline	quinoline	NN
cord-300872-blycbi4u	386	10	-	-	HYPH
cord-300872-blycbi4u	386	11	based	base	VBN
cord-300872-blycbi4u	386	12	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	386	13	-	-	HYPH
cord-300872-blycbi4u	386	14	triazole	triazole	NN
cord-300872-blycbi4u	386	15	derivatives	derivative	NNS
cord-300872-blycbi4u	386	16	(	(	-LRB-
cord-300872-blycbi4u	386	17	Scheme	scheme	NN
cord-300872-blycbi4u	386	18	14	14	CD
cord-300872-blycbi4u	386	19	)	)	-RRB-
cord-300872-blycbi4u	386	20	based	base	VBN
cord-300872-blycbi4u	386	21	on	on	IN
cord-300872-blycbi4u	386	22	the	the	DT
cord-300872-blycbi4u	386	23	hybrid	hybrid	JJ
cord-300872-blycbi4u	386	24	strategy	strategy	NN
cord-300872-blycbi4u	386	25	of	of	IN
cord-300872-blycbi4u	386	26	nitrogen	nitrogen	NN
cord-300872-blycbi4u	386	27	-	-	HYPH
cord-300872-blycbi4u	386	28	containing	contain	VBG
cord-300872-blycbi4u	386	29	heterocyclic	heterocyclic	JJ
cord-300872-blycbi4u	386	30	scaffolds	scaffold	NNS
cord-300872-blycbi4u	386	31	[	[	-LRB-
cord-300872-blycbi4u	386	32	36	36	CD
cord-300872-blycbi4u	386	33	]	]	-RRB-
cord-300872-blycbi4u	386	34	.	.	.
cord-300872-blycbi4u	387	1	These	these	DT
cord-300872-blycbi4u	387	2	compounds	compound	NNS
cord-300872-blycbi4u	387	3	were	be	VBD
cord-300872-blycbi4u	387	4	considered	consider	VBN
cord-300872-blycbi4u	387	5	to	to	TO
cord-300872-blycbi4u	387	6	be	be	VB
cord-300872-blycbi4u	387	7	high	high	JJ
cord-300872-blycbi4u	387	8	-	-	HYPH
cord-300872-blycbi4u	387	9	impact	impact	NN
cord-300872-blycbi4u	387	10	motifs	motif	NNS
cord-300872-blycbi4u	387	11	with	with	IN
cord-300872-blycbi4u	387	12	a	a	DT
cord-300872-blycbi4u	387	13	wide	wide	JJ
cord-300872-blycbi4u	387	14	range	range	NN
cord-300872-blycbi4u	387	15	of	of	IN
cord-300872-blycbi4u	387	16	biological	biological	JJ
cord-300872-blycbi4u	387	17	activities	activity	NNS
cord-300872-blycbi4u	387	18	[	[	-LRB-
cord-300872-blycbi4u	387	19	37	37	CD
cord-300872-blycbi4u	387	20	,	,	,
cord-300872-blycbi4u	387	21	38	38	CD
cord-300872-blycbi4u	387	22	]	]	-RRB-
cord-300872-blycbi4u	387	23	.	.	.
cord-300872-blycbi4u	388	1	The	the	DT
cord-300872-blycbi4u	388	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	388	3	strategy	strategy	NN
cord-300872-blycbi4u	388	4	was	be	VBD
cord-300872-blycbi4u	388	5	based	base	VBN
cord-300872-blycbi4u	388	6	on	on	IN
cord-300872-blycbi4u	388	7	the	the	DT
cord-300872-blycbi4u	388	8	treatment	treatment	NN
cord-300872-blycbi4u	388	9	of	of	IN
cord-300872-blycbi4u	388	10	1	1	CD
cord-300872-blycbi4u	388	11	with	with	IN
cord-300872-blycbi4u	388	12	carbonate	carbonate	NN
cord-300872-blycbi4u	388	13	to	to	TO
cord-300872-blycbi4u	388	14	produce	produce	VB
cord-300872-blycbi4u	388	15	the	the	DT
cord-300872-blycbi4u	388	16	phenolate	phenolate	NN
cord-300872-blycbi4u	388	17	anion	anion	NN
cord-300872-blycbi4u	388	18	,	,	,
cord-300872-blycbi4u	388	19	which	which	WDT
cord-300872-blycbi4u	388	20	reacts	react	VBZ
cord-300872-blycbi4u	388	21	with	with	IN
cord-300872-blycbi4u	388	22	ethyl	ethyl	NN
cord-300872-blycbi4u	388	23	chloroacetate	chloroacetate	NNP
cord-300872-blycbi4u	388	24	under	under	IN
cord-300872-blycbi4u	388	25	SN2	sn2	JJ
cord-300872-blycbi4u	388	26	conditions	condition	NNS
cord-300872-blycbi4u	388	27	to	to	TO
cord-300872-blycbi4u	388	28	afford	afford	VB
cord-300872-blycbi4u	388	29	the	the	DT
cord-300872-blycbi4u	388	30	corresponding	correspond	VBG
cord-300872-blycbi4u	388	31	intermediate	intermediate	NN
cord-300872-blycbi4u	388	32	.	.	.
cord-300872-blycbi4u	389	1	Reaction	reaction	NN
cord-300872-blycbi4u	389	2	of	of	IN
cord-300872-blycbi4u	389	3	this	this	DT
cord-300872-blycbi4u	389	4	intermediate	intermediate	JJ
cord-300872-blycbi4u	389	5	with	with	IN
cord-300872-blycbi4u	389	6	hydrazine	hydrazine	NN
cord-300872-blycbi4u	389	7	produced	produce	VBN
cord-300872-blycbi4u	389	8	54	54	CD
cord-300872-blycbi4u	389	9	,	,	,
cord-300872-blycbi4u	389	10	which	which	WDT
cord-300872-blycbi4u	389	11	undergoes	undergo	VBZ
cord-300872-blycbi4u	389	12	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	389	13	cyclization	cyclization	NN
cord-300872-blycbi4u	389	14	in	in	IN
cord-300872-blycbi4u	389	15	the	the	DT
cord-300872-blycbi4u	389	16	presence	presence	NN
cord-300872-blycbi4u	389	17	of	of	IN
cord-300872-blycbi4u	389	18	carbon	carbon	NN
cord-300872-blycbi4u	389	19	disulfide	disulfide	NN
cord-300872-blycbi4u	389	20	and	and	CC
cord-300872-blycbi4u	389	21	the	the	DT
cord-300872-blycbi4u	389	22	base	base	NN
cord-300872-blycbi4u	389	23	(	(	-LRB-
cord-300872-blycbi4u	389	24	KOH	KOH	NNP
cord-300872-blycbi4u	389	25	)	)	-RRB-
cord-300872-blycbi4u	389	26	to	to	TO
cord-300872-blycbi4u	389	27	give	give	VB
cord-300872-blycbi4u	389	28	compound	compound	NN
cord-300872-blycbi4u	389	29	55	55	CD
cord-300872-blycbi4u	389	30	(	(	-LRB-
cord-300872-blycbi4u	389	31	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	389	32	)	)	-RRB-
cord-300872-blycbi4u	389	33	after	after	IN
cord-300872-blycbi4u	389	34	acidification	acidification	NN
cord-300872-blycbi4u	389	35	.	.	.
cord-300872-blycbi4u	390	1	The	the	DT
cord-300872-blycbi4u	390	2	thiol	thiol	NN
cord-300872-blycbi4u	390	3	group	group	NN
cord-300872-blycbi4u	390	4	(	(	-LRB-
cord-300872-blycbi4u	390	5	Ar	Ar	NNP
cord-300872-blycbi4u	390	6	-	-	HYPH
cord-300872-blycbi4u	390	7	SH	SH	NNP
cord-300872-blycbi4u	390	8	)	)	-RRB-
cord-300872-blycbi4u	390	9	in	in	IN
cord-300872-blycbi4u	390	10	55	55	CD
cord-300872-blycbi4u	390	11	is	be	VBZ
cord-300872-blycbi4u	390	12	acidic	acidic	JJ
cord-300872-blycbi4u	390	13	and	and	CC
cord-300872-blycbi4u	390	14	gives	give	VBZ
cord-300872-blycbi4u	390	15	the	the	DT
cord-300872-blycbi4u	390	16	Ar	Ar	NNP
cord-300872-blycbi4u	390	17	-	-	HYPH
cord-300872-blycbi4u	390	18	Sanion	Sanion	NNP
cord-300872-blycbi4u	390	19	upon	upon	IN
cord-300872-blycbi4u	390	20	treatment	treatment	NN
cord-300872-blycbi4u	390	21	with	with	IN
cord-300872-blycbi4u	390	22	a	a	DT
cord-300872-blycbi4u	390	23	base	base	NN
cord-300872-blycbi4u	390	24	.	.	.
cord-300872-blycbi4u	391	1	Then	then	RB
cord-300872-blycbi4u	391	2	,	,	,
cord-300872-blycbi4u	391	3	the	the	DT
cord-300872-blycbi4u	391	4	corresponding	corresponding	JJ
cord-300872-blycbi4u	391	5	anion	anion	NN
cord-300872-blycbi4u	391	6	reacts	react	VBZ
cord-300872-blycbi4u	391	7	with	with	IN
cord-300872-blycbi4u	391	8	propargyl	propargyl	NNS
cord-300872-blycbi4u	391	9	bromide	bromide	NN
cord-300872-blycbi4u	391	10	to	to	TO
cord-300872-blycbi4u	391	11	afford	afford	VB
cord-300872-blycbi4u	391	12	compound	compound	NN
cord-300872-blycbi4u	391	13	56	56	CD
cord-300872-blycbi4u	391	14	.	.	.
cord-300872-blycbi4u	392	1	Finally	finally	RB
cord-300872-blycbi4u	392	2	,	,	,
cord-300872-blycbi4u	392	3	reaction	reaction	NN
cord-300872-blycbi4u	392	4	of	of	IN
cord-300872-blycbi4u	392	5	various	various	JJ
cord-300872-blycbi4u	392	6	azide	azide	NN
cord-300872-blycbi4u	392	7	derivatives	derivative	NNS
cord-300872-blycbi4u	392	8	of	of	IN
cord-300872-blycbi4u	392	9	56	56	CD
cord-300872-blycbi4u	392	10	yielded	yield	VBD
cord-300872-blycbi4u	392	11	the	the	DT
cord-300872-blycbi4u	392	12	target	target	NN
cord-300872-blycbi4u	392	13	derivative	derivative	JJ
cord-300872-blycbi4u	392	14	57	57	CD
cord-300872-blycbi4u	392	15	through	through	IN
cord-300872-blycbi4u	392	16	a	a	DT
cord-300872-blycbi4u	392	17	(	(	-LRB-
cord-300872-blycbi4u	392	18	3	3	CD
cord-300872-blycbi4u	392	19	+	+	SYM
cord-300872-blycbi4u	392	20	2	2	CD
cord-300872-blycbi4u	392	21	)	)	-RRB-
cord-300872-blycbi4u	392	22	cycloaddition	cycloaddition	NN
cord-300872-blycbi4u	392	23	mechanism	mechanism	NN
cord-300872-blycbi4u	392	24	.	.	.
cord-300872-blycbi4u	393	1	In	in	IN
cord-300872-blycbi4u	393	2	addition	addition	NN
cord-300872-blycbi4u	393	3	,	,	,
cord-300872-blycbi4u	393	4	Shamsi	Shamsi	NNP
cord-300872-blycbi4u	393	5	and	and	CC
cord-300872-blycbi4u	393	6	coworkers	coworker	NNS
cord-300872-blycbi4u	393	7	prepared	prepare	VBD
cord-300872-blycbi4u	393	8	16	16	CD
cord-300872-blycbi4u	393	9	quinoline	quinoline	NN
cord-300872-blycbi4u	393	10	-	-	HYPH
cord-300872-blycbi4u	393	11	based	base	VBN
cord-300872-blycbi4u	393	12	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	393	13	-	-	HYPH
cord-300872-blycbi4u	393	14	triazole	triazole	NN
cord-300872-blycbi4u	393	15	derivatives	derivative	NNS
cord-300872-blycbi4u	393	16	(	(	-LRB-
cord-300872-blycbi4u	393	17	Scheme	scheme	NN
cord-300872-blycbi4u	393	18	14	14	CD
cord-300872-blycbi4u	393	19	)	)	-RRB-
cord-300872-blycbi4u	393	20	based	base	VBN
cord-300872-blycbi4u	393	21	on	on	IN
cord-300872-blycbi4u	393	22	the	the	DT
cord-300872-blycbi4u	393	23	hybrid	hybrid	JJ
cord-300872-blycbi4u	393	24	strategy	strategy	NN
cord-300872-blycbi4u	393	25	of	of	IN
cord-300872-blycbi4u	393	26	nitrogen	nitrogen	NN
cord-300872-blycbi4u	393	27	-	-	HYPH
cord-300872-blycbi4u	393	28	containing	contain	VBG
cord-300872-blycbi4u	393	29	heterocyclic	heterocyclic	JJ
cord-300872-blycbi4u	393	30	scaffolds	scaffold	NNS
cord-300872-blycbi4u	393	31	[	[	-LRB-
cord-300872-blycbi4u	393	32	36	36	CD
cord-300872-blycbi4u	393	33	]	]	-RRB-
cord-300872-blycbi4u	393	34	.	.	.
cord-300872-blycbi4u	394	1	These	these	DT
cord-300872-blycbi4u	394	2	compounds	compound	NNS
cord-300872-blycbi4u	394	3	were	be	VBD
cord-300872-blycbi4u	394	4	considered	consider	VBN
cord-300872-blycbi4u	394	5	to	to	TO
cord-300872-blycbi4u	394	6	be	be	VB
cord-300872-blycbi4u	394	7	high	high	JJ
cord-300872-blycbi4u	394	8	-	-	HYPH
cord-300872-blycbi4u	394	9	impact	impact	NN
cord-300872-blycbi4u	394	10	motifs	motif	NNS
cord-300872-blycbi4u	394	11	with	with	IN
cord-300872-blycbi4u	394	12	a	a	DT
cord-300872-blycbi4u	394	13	wide	wide	JJ
cord-300872-blycbi4u	394	14	range	range	NN
cord-300872-blycbi4u	394	15	of	of	IN
cord-300872-blycbi4u	394	16	biological	biological	JJ
cord-300872-blycbi4u	394	17	activities	activity	NNS
cord-300872-blycbi4u	394	18	[	[	-LRB-
cord-300872-blycbi4u	394	19	37	37	CD
cord-300872-blycbi4u	394	20	,	,	,
cord-300872-blycbi4u	394	21	38	38	CD
cord-300872-blycbi4u	394	22	]	]	-RRB-
cord-300872-blycbi4u	394	23	.	.	.
cord-300872-blycbi4u	395	1	The	the	DT
cord-300872-blycbi4u	395	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	395	3	strategy	strategy	NN
cord-300872-blycbi4u	395	4	was	be	VBD
cord-300872-blycbi4u	395	5	based	base	VBN
cord-300872-blycbi4u	395	6	on	on	IN
cord-300872-blycbi4u	395	7	the	the	DT
cord-300872-blycbi4u	395	8	treatment	treatment	NN
cord-300872-blycbi4u	395	9	of	of	IN
cord-300872-blycbi4u	395	10	1	1	CD
cord-300872-blycbi4u	395	11	with	with	IN
cord-300872-blycbi4u	395	12	carbonate	carbonate	NN
cord-300872-blycbi4u	395	13	to	to	TO
cord-300872-blycbi4u	395	14	produce	produce	VB
cord-300872-blycbi4u	395	15	the	the	DT
cord-300872-blycbi4u	395	16	phenolate	phenolate	NN
cord-300872-blycbi4u	395	17	anion	anion	NN
cord-300872-blycbi4u	395	18	,	,	,
cord-300872-blycbi4u	395	19	which	which	WDT
cord-300872-blycbi4u	395	20	reacts	react	VBZ
cord-300872-blycbi4u	395	21	with	with	IN
cord-300872-blycbi4u	395	22	ethyl	ethyl	NN
cord-300872-blycbi4u	395	23	chloroacetate	chloroacetate	NN
cord-300872-blycbi4u	395	24	under	under	IN
cord-300872-blycbi4u	395	25	S	S	NNP
cord-300872-blycbi4u	395	26	N	n	CD
cord-300872-blycbi4u	395	27	2	2	CD
cord-300872-blycbi4u	395	28	conditions	condition	NNS
cord-300872-blycbi4u	395	29	to	to	TO
cord-300872-blycbi4u	395	30	afford	afford	VB
cord-300872-blycbi4u	395	31	the	the	DT
cord-300872-blycbi4u	395	32	corresponding	correspond	VBG
cord-300872-blycbi4u	395	33	intermediate	intermediate	NN
cord-300872-blycbi4u	395	34	.	.	.
cord-300872-blycbi4u	396	1	Reaction	reaction	NN
cord-300872-blycbi4u	396	2	of	of	IN
cord-300872-blycbi4u	396	3	this	this	DT
cord-300872-blycbi4u	396	4	intermediate	intermediate	JJ
cord-300872-blycbi4u	396	5	with	with	IN
cord-300872-blycbi4u	396	6	hydrazine	hydrazine	NN
cord-300872-blycbi4u	396	7	produced	produce	VBN
cord-300872-blycbi4u	396	8	54	54	CD
cord-300872-blycbi4u	396	9	,	,	,
cord-300872-blycbi4u	396	10	which	which	WDT
cord-300872-blycbi4u	396	11	undergoes	undergo	VBZ
cord-300872-blycbi4u	396	12	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	396	13	cyclization	cyclization	NN
cord-300872-blycbi4u	396	14	in	in	IN
cord-300872-blycbi4u	396	15	the	the	DT
cord-300872-blycbi4u	396	16	presence	presence	NN
cord-300872-blycbi4u	396	17	of	of	IN
cord-300872-blycbi4u	396	18	carbon	carbon	NN
cord-300872-blycbi4u	396	19	disulfide	disulfide	NN
cord-300872-blycbi4u	396	20	and	and	CC
cord-300872-blycbi4u	396	21	the	the	DT
cord-300872-blycbi4u	396	22	base	base	NN
cord-300872-blycbi4u	396	23	(	(	-LRB-
cord-300872-blycbi4u	396	24	KOH	KOH	NNP
cord-300872-blycbi4u	396	25	)	)	-RRB-
cord-300872-blycbi4u	396	26	to	to	TO
cord-300872-blycbi4u	396	27	give	give	VB
cord-300872-blycbi4u	396	28	compound	compound	NN
cord-300872-blycbi4u	396	29	55	55	CD
cord-300872-blycbi4u	396	30	(	(	-LRB-
cord-300872-blycbi4u	396	31	1,3,4-oxadiazole	1,3,4-oxadiazole	CD
cord-300872-blycbi4u	396	32	)	)	-RRB-
cord-300872-blycbi4u	396	33	after	after	IN
cord-300872-blycbi4u	396	34	acidification	acidification	NN
cord-300872-blycbi4u	396	35	.	.	.
cord-300872-blycbi4u	397	1	The	the	DT
cord-300872-blycbi4u	397	2	thiol	thiol	NN
cord-300872-blycbi4u	397	3	group	group	NN
cord-300872-blycbi4u	397	4	(	(	-LRB-
cord-300872-blycbi4u	397	5	Ar	Ar	NNP
cord-300872-blycbi4u	397	6	-	-	HYPH
cord-300872-blycbi4u	397	7	SH	SH	NNP
cord-300872-blycbi4u	397	8	)	)	-RRB-
cord-300872-blycbi4u	397	9	in	in	IN
cord-300872-blycbi4u	397	10	55	55	CD
cord-300872-blycbi4u	397	11	is	be	VBZ
cord-300872-blycbi4u	397	12	acidic	acidic	JJ
cord-300872-blycbi4u	397	13	and	and	CC
cord-300872-blycbi4u	397	14	gives	give	VBZ
cord-300872-blycbi4u	397	15	the	the	DT
cord-300872-blycbi4u	397	16	Ar	Ar	NNP
cord-300872-blycbi4u	397	17	-	-	HYPH
cord-300872-blycbi4u	397	18	S	S	NNP
cord-300872-blycbi4u	397	19	−	−	NNP
cord-300872-blycbi4u	397	20	anion	anion	NN
cord-300872-blycbi4u	397	21	upon	upon	IN
cord-300872-blycbi4u	397	22	treatment	treatment	NN
cord-300872-blycbi4u	397	23	with	with	IN
cord-300872-blycbi4u	397	24	a	a	DT
cord-300872-blycbi4u	397	25	base	base	NN
cord-300872-blycbi4u	397	26	.	.	.
cord-300872-blycbi4u	398	1	Then	then	RB
cord-300872-blycbi4u	398	2	,	,	,
cord-300872-blycbi4u	398	3	the	the	DT
cord-300872-blycbi4u	398	4	corresponding	corresponding	JJ
cord-300872-blycbi4u	398	5	anion	anion	NN
cord-300872-blycbi4u	398	6	reacts	react	VBZ
cord-300872-blycbi4u	398	7	with	with	IN
cord-300872-blycbi4u	398	8	propargyl	propargyl	NNS
cord-300872-blycbi4u	398	9	bromide	bromide	NN
cord-300872-blycbi4u	398	10	to	to	TO
cord-300872-blycbi4u	398	11	afford	afford	VB
cord-300872-blycbi4u	398	12	compound	compound	NN
cord-300872-blycbi4u	398	13	56	56	CD
cord-300872-blycbi4u	398	14	.	.	.
cord-300872-blycbi4u	399	1	Finally	finally	RB
cord-300872-blycbi4u	399	2	,	,	,
cord-300872-blycbi4u	399	3	reaction	reaction	NN
cord-300872-blycbi4u	399	4	of	of	IN
cord-300872-blycbi4u	399	5	various	various	JJ
cord-300872-blycbi4u	399	6	azide	azide	NN
cord-300872-blycbi4u	399	7	derivatives	derivative	NNS
cord-300872-blycbi4u	399	8	of	of	IN
cord-300872-blycbi4u	399	9	56	56	CD
cord-300872-blycbi4u	399	10	yielded	yield	VBD
cord-300872-blycbi4u	399	11	the	the	DT
cord-300872-blycbi4u	399	12	target	target	NN
cord-300872-blycbi4u	399	13	derivative	derivative	JJ
cord-300872-blycbi4u	399	14	57	57	CD
cord-300872-blycbi4u	399	15	through	through	IN
cord-300872-blycbi4u	399	16	a	a	DT
cord-300872-blycbi4u	399	17	(	(	-LRB-
cord-300872-blycbi4u	399	18	3	3	CD
cord-300872-blycbi4u	399	19	+	+	SYM
cord-300872-blycbi4u	399	20	2	2	CD
cord-300872-blycbi4u	399	21	)	)	-RRB-
cord-300872-blycbi4u	399	22	cycloaddition	cycloaddition	NN
cord-300872-blycbi4u	399	23	mechanism	mechanism	NN
cord-300872-blycbi4u	399	24	.	.	.
cord-300872-blycbi4u	400	1	The	the	DT
cord-300872-blycbi4u	400	2	anticancer	anticancer	JJ
cord-300872-blycbi4u	400	3	activities	activity	NNS
cord-300872-blycbi4u	400	4	of	of	IN
cord-300872-blycbi4u	400	5	all	all	DT
cord-300872-blycbi4u	400	6	of	of	IN
cord-300872-blycbi4u	400	7	these	these	DT
cord-300872-blycbi4u	400	8	derivatives	derivative	NNS
cord-300872-blycbi4u	400	9	were	be	VBD
cord-300872-blycbi4u	400	10	examined	examine	VBN
cord-300872-blycbi4u	400	11	against	against	IN
cord-300872-blycbi4u	400	12	four	four	CD
cord-300872-blycbi4u	400	13	different	different	JJ
cord-300872-blycbi4u	400	14	human	human	NN
cord-300872-blycbi4u	400	15	cancel	cancel	VB
cord-300872-blycbi4u	400	16	cell	cell	NN
cord-300872-blycbi4u	400	17	lines	line	NNS
cord-300872-blycbi4u	400	18	,	,	,
cord-300872-blycbi4u	400	19	namely	namely	RB
cord-300872-blycbi4u	400	20	human	human	JJ
cord-300872-blycbi4u	400	21	lung	lung	NN
cord-300872-blycbi4u	400	22	carcinoma	carcinoma	NN
cord-300872-blycbi4u	400	23	(	(	-LRB-
cord-300872-blycbi4u	400	24	A-549	a-549	NN
cord-300872-blycbi4u	400	25	)	)	-RRB-
cord-300872-blycbi4u	400	26	,	,	,
cord-300872-blycbi4u	400	27	hepatocellular	hepatocellular	JJ
cord-300872-blycbi4u	400	28	carcinoma	carcinoma	NN
cord-300872-blycbi4u	400	29	(	(	-LRB-
cord-300872-blycbi4u	400	30	HepG2	HepG2	NNP
cord-300872-blycbi4u	400	31	)	)	-RRB-
cord-300872-blycbi4u	400	32	,	,	,
cord-300872-blycbi4u	400	33	human	human	JJ
cord-300872-blycbi4u	400	34	cervical	cervical	JJ
cord-300872-blycbi4u	400	35	carcinoma	carcinoma	NN
cord-300872-blycbi4u	400	36	-	-	HYPH
cord-300872-blycbi4u	400	37	HPV18	hpv18	JJ
cord-300872-blycbi4u	400	38	(	(	-LRB-
cord-300872-blycbi4u	400	39	Hela	Hela	NNP
cord-300872-blycbi4u	400	40	)	)	-RRB-
cord-300872-blycbi4u	400	41	,	,	,
cord-300872-blycbi4u	400	42	and	and	CC
cord-300872-blycbi4u	400	43	human	human	JJ
cord-300872-blycbi4u	400	44	cervical	cervical	JJ
cord-300872-blycbi4u	400	45	carcinoma	carcinoma	NN
cord-300872-blycbi4u	400	46	-	-	HYPH
cord-300872-blycbi4u	400	47	HPV16	hpv16	NN
cord-300872-blycbi4u	400	48	(	(	-LRB-
cord-300872-blycbi4u	400	49	SiHa	SiHa	NNP
cord-300872-blycbi4u	400	50	)	)	-RRB-
cord-300872-blycbi4u	400	51	,	,	,
cord-300872-blycbi4u	400	52	using	use	VBG
cord-300872-blycbi4u	400	53	the	the	DT
cord-300872-blycbi4u	400	54	MMT	MMT	NNP
cord-300872-blycbi4u	400	55	colorimetric	colorimetric	JJ
cord-300872-blycbi4u	400	56	assay	assay	NN
cord-300872-blycbi4u	400	57	;	;	:
cord-300872-blycbi4u	400	58	normal	normal	JJ
cord-300872-blycbi4u	400	59	cells	cell	NNS
cord-300872-blycbi4u	400	60	were	be	VBD
cord-300872-blycbi4u	400	61	used	use	VBN
cord-300872-blycbi4u	400	62	as	as	IN
cord-300872-blycbi4u	400	63	controls	control	NNS
cord-300872-blycbi4u	400	64	,	,	,
cord-300872-blycbi4u	400	65	whereas	whereas	IN
cord-300872-blycbi4u	400	66	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	400	67	was	be	VBD
cord-300872-blycbi4u	400	68	used	use	VBN
cord-300872-blycbi4u	400	69	as	as	IN
cord-300872-blycbi4u	400	70	the	the	DT
cord-300872-blycbi4u	400	71	reference	reference	NN
cord-300872-blycbi4u	400	72	drug	drug	NN
cord-300872-blycbi4u	400	73	.	.	.
cord-300872-blycbi4u	401	1	The	the	DT
cord-300872-blycbi4u	401	2	results	result	NNS
cord-300872-blycbi4u	401	3	indicated	indicate	VBD
cord-300872-blycbi4u	401	4	that	that	IN
cord-300872-blycbi4u	401	5	the	the	DT
cord-300872-blycbi4u	401	6	product	product	NN
cord-300872-blycbi4u	401	7	with	with	IN
cord-300872-blycbi4u	401	8	an	an	DT
cord-300872-blycbi4u	401	9	o	o	NN
cord-300872-blycbi4u	401	10	-	-	HYPH
cord-300872-blycbi4u	401	11	chloro	chloro	NN
cord-300872-blycbi4u	401	12	substitution	substitution	NN
cord-300872-blycbi4u	401	13	on	on	IN
cord-300872-blycbi4u	401	14	the	the	DT
cord-300872-blycbi4u	401	15	phenyl	phenyl	NN
cord-300872-blycbi4u	401	16	ring	ring	NN
cord-300872-blycbi4u	401	17	was	be	VBD
cord-300872-blycbi4u	401	18	the	the	DT
cord-300872-blycbi4u	401	19	most	most	RBS
cord-300872-blycbi4u	401	20	potent	potent	JJ
cord-300872-blycbi4u	401	21	,	,	,
cord-300872-blycbi4u	401	22	with	with	IN
cord-300872-blycbi4u	401	23	an	an	DT
cord-300872-blycbi4u	401	24	IC	IC	NNP
cord-300872-blycbi4u	401	25	50	50	CD
cord-300872-blycbi4u	401	26	value	value	NN
cord-300872-blycbi4u	401	27	of	of	IN
cord-300872-blycbi4u	401	28	5.6	5.6	CD
cord-300872-blycbi4u	401	29	mM	mm	CD
cord-300872-blycbi4u	401	30	against	against	IN
cord-300872-blycbi4u	401	31	the	the	DT
cord-300872-blycbi4u	401	32	A-549	a-549	NN
cord-300872-blycbi4u	401	33	cell	cell	NN
cord-300872-blycbi4u	401	34	line	line	NN
cord-300872-blycbi4u	401	35	,	,	,
cord-300872-blycbi4u	401	36	which	which	WDT
cord-300872-blycbi4u	401	37	is	be	VBZ
cord-300872-blycbi4u	401	38	higher	high	JJR
cord-300872-blycbi4u	401	39	than	than	IN
cord-300872-blycbi4u	401	40	that	that	DT
cord-300872-blycbi4u	401	41	of	of	IN
cord-300872-blycbi4u	401	42	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	401	43	(	(	-LRB-
cord-300872-blycbi4u	401	44	IC	IC	NNP
cord-300872-blycbi4u	401	45	50	50	CD
cord-300872-blycbi4u	401	46	=	=	SYM
cord-300872-blycbi4u	401	47	1.83	1.83	CD
cord-300872-blycbi4u	401	48	mM	mm	CD
cord-300872-blycbi4u	401	49	)	)	-RRB-
cord-300872-blycbi4u	401	50	.	.	.
cord-300872-blycbi4u	402	1	Interestingly	interestingly	RB
cord-300872-blycbi4u	402	2	,	,	,
cord-300872-blycbi4u	402	3	this	this	DT
cord-300872-blycbi4u	402	4	compound	compound	NN
cord-300872-blycbi4u	402	5	was	be	VBD
cord-300872-blycbi4u	402	6	not	not	RB
cord-300872-blycbi4u	402	7	toxic	toxic	JJ
cord-300872-blycbi4u	402	8	towards	towards	IN
cord-300872-blycbi4u	402	9	normal	normal	JJ
cord-300872-blycbi4u	402	10	cells	cell	NNS
cord-300872-blycbi4u	402	11	(	(	-LRB-
cord-300872-blycbi4u	402	12	up	up	IN
cord-300872-blycbi4u	402	13	to	to	TO
cord-300872-blycbi4u	402	14	200	200	CD
cord-300872-blycbi4u	402	15	mM	mm	CD
cord-300872-blycbi4u	402	16	concentration	concentration	NN
cord-300872-blycbi4u	402	17	)	)	-RRB-
cord-300872-blycbi4u	402	18	.	.	.
cord-300872-blycbi4u	403	1	The	the	DT
cord-300872-blycbi4u	403	2	anticancer	anticancer	JJ
cord-300872-blycbi4u	403	3	activities	activity	NNS
cord-300872-blycbi4u	403	4	of	of	IN
cord-300872-blycbi4u	403	5	all	all	DT
cord-300872-blycbi4u	403	6	of	of	IN
cord-300872-blycbi4u	403	7	these	these	DT
cord-300872-blycbi4u	403	8	derivatives	derivative	NNS
cord-300872-blycbi4u	403	9	were	be	VBD
cord-300872-blycbi4u	403	10	examined	examine	VBN
cord-300872-blycbi4u	403	11	against	against	IN
cord-300872-blycbi4u	403	12	four	four	CD
cord-300872-blycbi4u	403	13	different	different	JJ
cord-300872-blycbi4u	403	14	human	human	NN
cord-300872-blycbi4u	403	15	cancel	cancel	VB
cord-300872-blycbi4u	403	16	cell	cell	NN
cord-300872-blycbi4u	403	17	lines	line	NNS
cord-300872-blycbi4u	403	18	,	,	,
cord-300872-blycbi4u	403	19	namely	namely	RB
cord-300872-blycbi4u	403	20	human	human	JJ
cord-300872-blycbi4u	403	21	lung	lung	NN
cord-300872-blycbi4u	403	22	carcinoma	carcinoma	NN
cord-300872-blycbi4u	403	23	(	(	-LRB-
cord-300872-blycbi4u	403	24	A-549	a-549	NN
cord-300872-blycbi4u	403	25	)	)	-RRB-
cord-300872-blycbi4u	403	26	,	,	,
cord-300872-blycbi4u	403	27	hepatocellular	hepatocellular	JJ
cord-300872-blycbi4u	403	28	carcinoma	carcinoma	NN
cord-300872-blycbi4u	403	29	(	(	-LRB-
cord-300872-blycbi4u	403	30	HepG2	HepG2	NNP
cord-300872-blycbi4u	403	31	)	)	-RRB-
cord-300872-blycbi4u	403	32	,	,	,
cord-300872-blycbi4u	403	33	human	human	JJ
cord-300872-blycbi4u	403	34	cervical	cervical	JJ
cord-300872-blycbi4u	403	35	carcinoma	carcinoma	NN
cord-300872-blycbi4u	403	36	-	-	HYPH
cord-300872-blycbi4u	403	37	HPV18	hpv18	JJ
cord-300872-blycbi4u	403	38	(	(	-LRB-
cord-300872-blycbi4u	403	39	Hela	Hela	NNP
cord-300872-blycbi4u	403	40	)	)	-RRB-
cord-300872-blycbi4u	403	41	,	,	,
cord-300872-blycbi4u	403	42	and	and	CC
cord-300872-blycbi4u	403	43	human	human	JJ
cord-300872-blycbi4u	403	44	cervical	cervical	JJ
cord-300872-blycbi4u	403	45	carcinoma	carcinoma	NN
cord-300872-blycbi4u	403	46	-	-	HYPH
cord-300872-blycbi4u	403	47	HPV16	hpv16	NN
cord-300872-blycbi4u	403	48	(	(	-LRB-
cord-300872-blycbi4u	403	49	SiHa	SiHa	NNP
cord-300872-blycbi4u	403	50	)	)	-RRB-
cord-300872-blycbi4u	403	51	,	,	,
cord-300872-blycbi4u	403	52	using	use	VBG
cord-300872-blycbi4u	403	53	the	the	DT
cord-300872-blycbi4u	403	54	MMT	MMT	NNP
cord-300872-blycbi4u	403	55	colorimetric	colorimetric	JJ
cord-300872-blycbi4u	403	56	assay	assay	NN
cord-300872-blycbi4u	403	57	;	;	:
cord-300872-blycbi4u	403	58	normal	normal	JJ
cord-300872-blycbi4u	403	59	cells	cell	NNS
cord-300872-blycbi4u	403	60	were	be	VBD
cord-300872-blycbi4u	403	61	used	use	VBN
cord-300872-blycbi4u	403	62	as	as	IN
cord-300872-blycbi4u	403	63	controls	control	NNS
cord-300872-blycbi4u	403	64	,	,	,
cord-300872-blycbi4u	403	65	whereas	whereas	IN
cord-300872-blycbi4u	403	66	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	403	67	was	be	VBD
cord-300872-blycbi4u	403	68	used	use	VBN
cord-300872-blycbi4u	403	69	as	as	IN
cord-300872-blycbi4u	403	70	the	the	DT
cord-300872-blycbi4u	403	71	reference	reference	NN
cord-300872-blycbi4u	403	72	drug	drug	NN
cord-300872-blycbi4u	403	73	.	.	.
cord-300872-blycbi4u	404	1	The	the	DT
cord-300872-blycbi4u	404	2	results	result	NNS
cord-300872-blycbi4u	404	3	indicated	indicate	VBD
cord-300872-blycbi4u	404	4	that	that	IN
cord-300872-blycbi4u	404	5	the	the	DT
cord-300872-blycbi4u	404	6	product	product	NN
cord-300872-blycbi4u	404	7	with	with	IN
cord-300872-blycbi4u	404	8	an	an	DT
cord-300872-blycbi4u	404	9	o	o	NN
cord-300872-blycbi4u	404	10	-	-	HYPH
cord-300872-blycbi4u	404	11	chloro	chloro	NN
cord-300872-blycbi4u	404	12	substitution	substitution	NN
cord-300872-blycbi4u	404	13	on	on	IN
cord-300872-blycbi4u	404	14	the	the	DT
cord-300872-blycbi4u	404	15	phenyl	phenyl	NN
cord-300872-blycbi4u	404	16	ring	ring	NN
cord-300872-blycbi4u	404	17	was	be	VBD
cord-300872-blycbi4u	404	18	the	the	DT
cord-300872-blycbi4u	404	19	most	most	RBS
cord-300872-blycbi4u	404	20	potent	potent	JJ
cord-300872-blycbi4u	404	21	,	,	,
cord-300872-blycbi4u	404	22	with	with	IN
cord-300872-blycbi4u	404	23	an	an	DT
cord-300872-blycbi4u	404	24	IC50	IC50	NNP
cord-300872-blycbi4u	404	25	value	value	NN
cord-300872-blycbi4u	404	26	of	of	IN
cord-300872-blycbi4u	404	27	5.6	5.6	CD
cord-300872-blycbi4u	404	28	mM	mm	CD
cord-300872-blycbi4u	404	29	against	against	IN
cord-300872-blycbi4u	404	30	the	the	DT
cord-300872-blycbi4u	404	31	A-549	a-549	NN
cord-300872-blycbi4u	404	32	cell	cell	NN
cord-300872-blycbi4u	404	33	line	line	NN
cord-300872-blycbi4u	404	34	,	,	,
cord-300872-blycbi4u	404	35	which	which	WDT
cord-300872-blycbi4u	404	36	is	be	VBZ
cord-300872-blycbi4u	404	37	higher	high	JJR
cord-300872-blycbi4u	404	38	than	than	IN
cord-300872-blycbi4u	404	39	that	that	DT
cord-300872-blycbi4u	404	40	of	of	IN
cord-300872-blycbi4u	404	41	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	404	42	(	(	-LRB-
cord-300872-blycbi4u	404	43	IC50	IC50	NNP
cord-300872-blycbi4u	404	44	=	=	SYM
cord-300872-blycbi4u	404	45	1.83	1.83	CD
cord-300872-blycbi4u	404	46	mM	mm	CD
cord-300872-blycbi4u	404	47	)	)	-RRB-
cord-300872-blycbi4u	404	48	.	.	.
cord-300872-blycbi4u	405	1	Interestingly	interestingly	RB
cord-300872-blycbi4u	405	2	,	,	,
cord-300872-blycbi4u	405	3	this	this	DT
cord-300872-blycbi4u	405	4	compound	compound	NN
cord-300872-blycbi4u	405	5	was	be	VBD
cord-300872-blycbi4u	405	6	not	not	RB
cord-300872-blycbi4u	405	7	toxic	toxic	JJ
cord-300872-blycbi4u	405	8	towards	towards	IN
cord-300872-blycbi4u	405	9	normal	normal	JJ
cord-300872-blycbi4u	405	10	cells	cell	NNS
cord-300872-blycbi4u	405	11	(	(	-LRB-
cord-300872-blycbi4u	405	12	up	up	IN
cord-300872-blycbi4u	405	13	to	to	TO
cord-300872-blycbi4u	405	14	200	200	CD
cord-300872-blycbi4u	405	15	mM	mm	CD
cord-300872-blycbi4u	405	16	concentration	concentration	NN
cord-300872-blycbi4u	405	17	)	)	-RRB-
cord-300872-blycbi4u	405	18	.	.	.
cord-300872-blycbi4u	406	1	A	a	DT
cord-300872-blycbi4u	406	2	series	series	NN
cord-300872-blycbi4u	406	3	of	of	IN
cord-300872-blycbi4u	406	4	styrylquinolines	styrylquinoline	NNS
cord-300872-blycbi4u	406	5	with	with	IN
cord-300872-blycbi4u	406	6	various	various	JJ
cord-300872-blycbi4u	406	7	substituents	substituent	NNS
cord-300872-blycbi4u	406	8	was	be	VBD
cord-300872-blycbi4u	406	9	prepared	prepare	VBN
cord-300872-blycbi4u	406	10	as	as	IN
cord-300872-blycbi4u	406	11	shown	show	VBN
cord-300872-blycbi4u	406	12	in	in	IN
cord-300872-blycbi4u	406	13	Scheme	scheme	NN
cord-300872-blycbi4u	406	14	15	15	CD
cord-300872-blycbi4u	406	15	[	[	-LRB-
cord-300872-blycbi4u	406	16	39	39	CD
cord-300872-blycbi4u	406	17	]	]	-RRB-
cord-300872-blycbi4u	406	18	.	.	.
cord-300872-blycbi4u	407	1	In	in	IN
cord-300872-blycbi4u	407	2	the	the	DT
cord-300872-blycbi4u	407	3	first	first	JJ
cord-300872-blycbi4u	407	4	step	step	NN
cord-300872-blycbi4u	407	5	of	of	IN
cord-300872-blycbi4u	407	6	the	the	DT
cord-300872-blycbi4u	407	7	synthesis	synthesis	NN
cord-300872-blycbi4u	407	8	,	,	,
cord-300872-blycbi4u	407	9	the	the	DT
cord-300872-blycbi4u	407	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	407	11	group	group	NN
cord-300872-blycbi4u	407	12	in	in	IN
cord-300872-blycbi4u	407	13	58	58	CD
cord-300872-blycbi4u	407	14	was	be	VBD
cord-300872-blycbi4u	407	15	protected	protect	VBN
cord-300872-blycbi4u	407	16	by	by	IN
cord-300872-blycbi4u	407	17	conversion	conversion	NN
cord-300872-blycbi4u	407	18	into	into	IN
cord-300872-blycbi4u	407	19	the	the	DT
cord-300872-blycbi4u	407	20	acetyl	acetyl	NN
cord-300872-blycbi4u	407	21	analogue	analogue	NN
cord-300872-blycbi4u	407	22	59	59	CD
cord-300872-blycbi4u	407	23	.	.	.
cord-300872-blycbi4u	408	1	Then	then	RB
cord-300872-blycbi4u	408	2	,	,	,
cord-300872-blycbi4u	408	3	a	a	DT
cord-300872-blycbi4u	408	4	condensation	condensation	NN
cord-300872-blycbi4u	408	5	reaction	reaction	NN
cord-300872-blycbi4u	408	6	between	between	IN
cord-300872-blycbi4u	408	7	a	a	DT
cord-300872-blycbi4u	408	8	methyl	methyl	NN
cord-300872-blycbi4u	408	9	group	group	NN
cord-300872-blycbi4u	408	10	at	at	IN
cord-300872-blycbi4u	408	11	position	position	NN
cord-300872-blycbi4u	408	12	2	2	CD
cord-300872-blycbi4u	408	13	of	of	IN
cord-300872-blycbi4u	408	14	protected	protect	VBN
cord-300872-blycbi4u	408	15	8hydroxyquinoline	8hydroxyquinoline	CD
cord-300872-blycbi4u	408	16	and	and	CC
cord-300872-blycbi4u	408	17	appropriate	appropriate	JJ
cord-300872-blycbi4u	408	18	aromatic	aromatic	JJ
cord-300872-blycbi4u	408	19	aldehydes	aldehyde	NNS
cord-300872-blycbi4u	408	20	as	as	IN
cord-300872-blycbi4u	408	21	carried	carry	VBN
cord-300872-blycbi4u	408	22	out	out	RP
cord-300872-blycbi4u	408	23	using	use	VBG
cord-300872-blycbi4u	408	24	microwave	microwave	NN
cord-300872-blycbi4u	408	25	heating	heating	NN
cord-300872-blycbi4u	408	26	or	or	CC
cord-300872-blycbi4u	408	27	conventional	conventional	JJ
cord-300872-blycbi4u	408	28	procedures	procedure	NNS
cord-300872-blycbi4u	408	29	[	[	-LRB-
cord-300872-blycbi4u	408	30	40	40	CD
cord-300872-blycbi4u	408	31	]	]	-RRB-
cord-300872-blycbi4u	408	32	.	.	.
cord-300872-blycbi4u	409	1	Finally	finally	RB
cord-300872-blycbi4u	409	2	,	,	,
cord-300872-blycbi4u	409	3	deprotection	deprotection	NN
cord-300872-blycbi4u	409	4	of	of	IN
cord-300872-blycbi4u	409	5	the	the	DT
cord-300872-blycbi4u	409	6	acyl	acyl	NNP
cord-300872-blycbi4u	409	7	group	group	NN
cord-300872-blycbi4u	409	8	was	be	VBD
cord-300872-blycbi4u	409	9	achieved	achieve	VBN
cord-300872-blycbi4u	409	10	with	with	IN
cord-300872-blycbi4u	409	11	carbonate	carbonate	NN
cord-300872-blycbi4u	409	12	anion	anion	NN
cord-300872-blycbi4u	409	13	-	-	HYPH
cord-300872-blycbi4u	409	14	methanol	methanol	NN
cord-300872-blycbi4u	409	15	or	or	CC
cord-300872-blycbi4u	409	16	pyridine	pyridine	NN
cord-300872-blycbi4u	409	17	-	-	HYPH
cord-300872-blycbi4u	409	18	water	water	NN
cord-300872-blycbi4u	409	19	mixture	mixture	NN
cord-300872-blycbi4u	409	20	afforded	afford	VBD
cord-300872-blycbi4u	409	21	the	the	DT
cord-300872-blycbi4u	409	22	target	target	NN
cord-300872-blycbi4u	409	23	products	product	NNS
cord-300872-blycbi4u	409	24	60	60	CD
cord-300872-blycbi4u	409	25	.	.	.
cord-300872-blycbi4u	410	1	A	a	DT
cord-300872-blycbi4u	410	2	series	series	NN
cord-300872-blycbi4u	410	3	of	of	IN
cord-300872-blycbi4u	410	4	styrylquinolines	styrylquinoline	NNS
cord-300872-blycbi4u	410	5	with	with	IN
cord-300872-blycbi4u	410	6	various	various	JJ
cord-300872-blycbi4u	410	7	substituents	substituent	NNS
cord-300872-blycbi4u	410	8	was	be	VBD
cord-300872-blycbi4u	410	9	prepared	prepare	VBN
cord-300872-blycbi4u	410	10	as	as	IN
cord-300872-blycbi4u	410	11	shown	show	VBN
cord-300872-blycbi4u	410	12	in	in	IN
cord-300872-blycbi4u	410	13	Scheme	scheme	NN
cord-300872-blycbi4u	410	14	15	15	CD
cord-300872-blycbi4u	410	15	[	[	-LRB-
cord-300872-blycbi4u	410	16	39	39	CD
cord-300872-blycbi4u	410	17	]	]	-RRB-
cord-300872-blycbi4u	410	18	.	.	.
cord-300872-blycbi4u	411	1	In	in	IN
cord-300872-blycbi4u	411	2	the	the	DT
cord-300872-blycbi4u	411	3	first	first	JJ
cord-300872-blycbi4u	411	4	step	step	NN
cord-300872-blycbi4u	411	5	of	of	IN
cord-300872-blycbi4u	411	6	the	the	DT
cord-300872-blycbi4u	411	7	synthesis	synthesis	NN
cord-300872-blycbi4u	411	8	,	,	,
cord-300872-blycbi4u	411	9	the	the	DT
cord-300872-blycbi4u	411	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	411	11	group	group	NN
cord-300872-blycbi4u	411	12	in	in	IN
cord-300872-blycbi4u	411	13	58	58	CD
cord-300872-blycbi4u	411	14	was	be	VBD
cord-300872-blycbi4u	411	15	protected	protect	VBN
cord-300872-blycbi4u	411	16	by	by	IN
cord-300872-blycbi4u	411	17	conversion	conversion	NN
cord-300872-blycbi4u	411	18	into	into	IN
cord-300872-blycbi4u	411	19	the	the	DT
cord-300872-blycbi4u	411	20	acetyl	acetyl	NN
cord-300872-blycbi4u	411	21	analogue	analogue	NN
cord-300872-blycbi4u	411	22	59	59	CD
cord-300872-blycbi4u	411	23	.	.	.
cord-300872-blycbi4u	412	1	Then	then	RB
cord-300872-blycbi4u	412	2	,	,	,
cord-300872-blycbi4u	412	3	a	a	DT
cord-300872-blycbi4u	412	4	condensation	condensation	NN
cord-300872-blycbi4u	412	5	reaction	reaction	NN
cord-300872-blycbi4u	412	6	between	between	IN
cord-300872-blycbi4u	412	7	a	a	DT
cord-300872-blycbi4u	412	8	methyl	methyl	NN
cord-300872-blycbi4u	412	9	group	group	NN
cord-300872-blycbi4u	412	10	at	at	IN
cord-300872-blycbi4u	412	11	position	position	NN
cord-300872-blycbi4u	412	12	2	2	CD
cord-300872-blycbi4u	412	13	of	of	IN
cord-300872-blycbi4u	412	14	protected	protect	VBN
cord-300872-blycbi4u	412	15	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	412	16	and	and	CC
cord-300872-blycbi4u	412	17	appropriate	appropriate	JJ
cord-300872-blycbi4u	412	18	aromatic	aromatic	JJ
cord-300872-blycbi4u	412	19	aldehydes	aldehyde	NNS
cord-300872-blycbi4u	412	20	as	as	IN
cord-300872-blycbi4u	412	21	carried	carry	VBN
cord-300872-blycbi4u	412	22	out	out	RP
cord-300872-blycbi4u	412	23	using	use	VBG
cord-300872-blycbi4u	412	24	microwave	microwave	NN
cord-300872-blycbi4u	412	25	heating	heating	NN
cord-300872-blycbi4u	412	26	or	or	CC
cord-300872-blycbi4u	412	27	conventional	conventional	JJ
cord-300872-blycbi4u	412	28	procedures	procedure	NNS
cord-300872-blycbi4u	412	29	[	[	-LRB-
cord-300872-blycbi4u	412	30	40	40	CD
cord-300872-blycbi4u	412	31	]	]	-RRB-
cord-300872-blycbi4u	412	32	.	.	.
cord-300872-blycbi4u	413	1	Finally	finally	RB
cord-300872-blycbi4u	413	2	,	,	,
cord-300872-blycbi4u	413	3	deprotection	deprotection	NN
cord-300872-blycbi4u	413	4	of	of	IN
cord-300872-blycbi4u	413	5	the	the	DT
cord-300872-blycbi4u	413	6	acyl	acyl	NNP
cord-300872-blycbi4u	413	7	group	group	NN
cord-300872-blycbi4u	413	8	was	be	VBD
cord-300872-blycbi4u	413	9	achieved	achieve	VBN
cord-300872-blycbi4u	413	10	with	with	IN
cord-300872-blycbi4u	413	11	carbonate	carbonate	NN
cord-300872-blycbi4u	413	12	anion	anion	NN
cord-300872-blycbi4u	413	13	-	-	HYPH
cord-300872-blycbi4u	413	14	methanol	methanol	NN
cord-300872-blycbi4u	413	15	or	or	CC
cord-300872-blycbi4u	413	16	pyridine	pyridine	NN
cord-300872-blycbi4u	413	17	-	-	HYPH
cord-300872-blycbi4u	413	18	water	water	NN
cord-300872-blycbi4u	413	19	mixture	mixture	NN
cord-300872-blycbi4u	413	20	afforded	afford	VBD
cord-300872-blycbi4u	413	21	the	the	DT
cord-300872-blycbi4u	413	22	target	target	NN
cord-300872-blycbi4u	413	23	products	product	NNS
cord-300872-blycbi4u	413	24	60	60	CD
cord-300872-blycbi4u	413	25	.	.	.
cord-300872-blycbi4u	414	1	The	the	DT
cord-300872-blycbi4u	414	2	anticancer	anticancer	JJ
cord-300872-blycbi4u	414	3	activities	activity	NNS
cord-300872-blycbi4u	414	4	of	of	IN
cord-300872-blycbi4u	414	5	all	all	DT
cord-300872-blycbi4u	414	6	of	of	IN
cord-300872-blycbi4u	414	7	these	these	DT
cord-300872-blycbi4u	414	8	derivatives	derivative	NNS
cord-300872-blycbi4u	414	9	were	be	VBD
cord-300872-blycbi4u	414	10	examined	examine	VBN
cord-300872-blycbi4u	414	11	against	against	IN
cord-300872-blycbi4u	414	12	four	four	CD
cord-300872-blycbi4u	414	13	different	different	JJ
cord-300872-blycbi4u	414	14	human	human	NN
cord-300872-blycbi4u	414	15	cancel	cancel	VB
cord-300872-blycbi4u	414	16	cell	cell	NN
cord-300872-blycbi4u	414	17	lines	line	NNS
cord-300872-blycbi4u	414	18	,	,	,
cord-300872-blycbi4u	414	19	namely	namely	RB
cord-300872-blycbi4u	414	20	human	human	JJ
cord-300872-blycbi4u	414	21	lung	lung	NN
cord-300872-blycbi4u	414	22	carcinoma	carcinoma	NN
cord-300872-blycbi4u	414	23	(	(	-LRB-
cord-300872-blycbi4u	414	24	A-549	a-549	NN
cord-300872-blycbi4u	414	25	)	)	-RRB-
cord-300872-blycbi4u	414	26	,	,	,
cord-300872-blycbi4u	414	27	hepatocellular	hepatocellular	JJ
cord-300872-blycbi4u	414	28	carcinoma	carcinoma	NN
cord-300872-blycbi4u	414	29	(	(	-LRB-
cord-300872-blycbi4u	414	30	HepG2	HepG2	NNP
cord-300872-blycbi4u	414	31	)	)	-RRB-
cord-300872-blycbi4u	414	32	,	,	,
cord-300872-blycbi4u	414	33	human	human	JJ
cord-300872-blycbi4u	414	34	cervical	cervical	JJ
cord-300872-blycbi4u	414	35	carcinoma	carcinoma	NN
cord-300872-blycbi4u	414	36	-	-	HYPH
cord-300872-blycbi4u	414	37	HPV18	hpv18	JJ
cord-300872-blycbi4u	414	38	(	(	-LRB-
cord-300872-blycbi4u	414	39	Hela	Hela	NNP
cord-300872-blycbi4u	414	40	)	)	-RRB-
cord-300872-blycbi4u	414	41	,	,	,
cord-300872-blycbi4u	414	42	and	and	CC
cord-300872-blycbi4u	414	43	human	human	JJ
cord-300872-blycbi4u	414	44	cervical	cervical	JJ
cord-300872-blycbi4u	414	45	carcinoma	carcinoma	NN
cord-300872-blycbi4u	414	46	-	-	HYPH
cord-300872-blycbi4u	414	47	HPV16	hpv16	NN
cord-300872-blycbi4u	414	48	(	(	-LRB-
cord-300872-blycbi4u	414	49	SiHa	SiHa	NNP
cord-300872-blycbi4u	414	50	)	)	-RRB-
cord-300872-blycbi4u	414	51	,	,	,
cord-300872-blycbi4u	414	52	using	use	VBG
cord-300872-blycbi4u	414	53	the	the	DT
cord-300872-blycbi4u	414	54	MMT	MMT	NNP
cord-300872-blycbi4u	414	55	colorimetric	colorimetric	JJ
cord-300872-blycbi4u	414	56	assay	assay	NN
cord-300872-blycbi4u	414	57	;	;	:
cord-300872-blycbi4u	414	58	normal	normal	JJ
cord-300872-blycbi4u	414	59	cells	cell	NNS
cord-300872-blycbi4u	414	60	were	be	VBD
cord-300872-blycbi4u	414	61	used	use	VBN
cord-300872-blycbi4u	414	62	as	as	IN
cord-300872-blycbi4u	414	63	controls	control	NNS
cord-300872-blycbi4u	414	64	,	,	,
cord-300872-blycbi4u	414	65	whereas	whereas	IN
cord-300872-blycbi4u	414	66	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	414	67	was	be	VBD
cord-300872-blycbi4u	414	68	used	use	VBN
cord-300872-blycbi4u	414	69	as	as	IN
cord-300872-blycbi4u	414	70	the	the	DT
cord-300872-blycbi4u	414	71	reference	reference	NN
cord-300872-blycbi4u	414	72	drug	drug	NN
cord-300872-blycbi4u	414	73	.	.	.
cord-300872-blycbi4u	415	1	The	the	DT
cord-300872-blycbi4u	415	2	results	result	NNS
cord-300872-blycbi4u	415	3	indicated	indicate	VBD
cord-300872-blycbi4u	415	4	that	that	IN
cord-300872-blycbi4u	415	5	the	the	DT
cord-300872-blycbi4u	415	6	product	product	NN
cord-300872-blycbi4u	415	7	with	with	IN
cord-300872-blycbi4u	415	8	an	an	DT
cord-300872-blycbi4u	415	9	o	o	NN
cord-300872-blycbi4u	415	10	-	-	HYPH
cord-300872-blycbi4u	415	11	chloro	chloro	NN
cord-300872-blycbi4u	415	12	substitution	substitution	NN
cord-300872-blycbi4u	415	13	on	on	IN
cord-300872-blycbi4u	415	14	the	the	DT
cord-300872-blycbi4u	415	15	phenyl	phenyl	NN
cord-300872-blycbi4u	415	16	ring	ring	NN
cord-300872-blycbi4u	415	17	was	be	VBD
cord-300872-blycbi4u	415	18	the	the	DT
cord-300872-blycbi4u	415	19	most	most	RBS
cord-300872-blycbi4u	415	20	potent	potent	JJ
cord-300872-blycbi4u	415	21	,	,	,
cord-300872-blycbi4u	415	22	with	with	IN
cord-300872-blycbi4u	415	23	an	an	DT
cord-300872-blycbi4u	415	24	IC50	IC50	NNP
cord-300872-blycbi4u	415	25	value	value	NN
cord-300872-blycbi4u	415	26	of	of	IN
cord-300872-blycbi4u	415	27	5.6	5.6	CD
cord-300872-blycbi4u	415	28	mM	mm	CD
cord-300872-blycbi4u	415	29	against	against	IN
cord-300872-blycbi4u	415	30	the	the	DT
cord-300872-blycbi4u	415	31	A-549	a-549	NN
cord-300872-blycbi4u	415	32	cell	cell	NN
cord-300872-blycbi4u	415	33	line	line	NN
cord-300872-blycbi4u	415	34	,	,	,
cord-300872-blycbi4u	415	35	which	which	WDT
cord-300872-blycbi4u	415	36	is	be	VBZ
cord-300872-blycbi4u	415	37	higher	high	JJR
cord-300872-blycbi4u	415	38	than	than	IN
cord-300872-blycbi4u	415	39	that	that	DT
cord-300872-blycbi4u	415	40	of	of	IN
cord-300872-blycbi4u	415	41	doxorubicin	doxorubicin	NN
cord-300872-blycbi4u	415	42	(	(	-LRB-
cord-300872-blycbi4u	415	43	IC50	IC50	NNP
cord-300872-blycbi4u	415	44	=	=	SYM
cord-300872-blycbi4u	415	45	1.83	1.83	CD
cord-300872-blycbi4u	415	46	mM	mm	CD
cord-300872-blycbi4u	415	47	)	)	-RRB-
cord-300872-blycbi4u	415	48	.	.	.
cord-300872-blycbi4u	416	1	Interestingly	interestingly	RB
cord-300872-blycbi4u	416	2	,	,	,
cord-300872-blycbi4u	416	3	this	this	DT
cord-300872-blycbi4u	416	4	compound	compound	NN
cord-300872-blycbi4u	416	5	was	be	VBD
cord-300872-blycbi4u	416	6	not	not	RB
cord-300872-blycbi4u	416	7	toxic	toxic	JJ
cord-300872-blycbi4u	416	8	towards	towards	IN
cord-300872-blycbi4u	416	9	normal	normal	JJ
cord-300872-blycbi4u	416	10	cells	cell	NNS
cord-300872-blycbi4u	416	11	(	(	-LRB-
cord-300872-blycbi4u	416	12	up	up	IN
cord-300872-blycbi4u	416	13	to	to	TO
cord-300872-blycbi4u	416	14	200	200	CD
cord-300872-blycbi4u	416	15	mM	mm	CD
cord-300872-blycbi4u	416	16	concentration	concentration	NN
cord-300872-blycbi4u	416	17	)	)	-RRB-
cord-300872-blycbi4u	416	18	.	.	.
cord-300872-blycbi4u	417	1	A	a	DT
cord-300872-blycbi4u	417	2	series	series	NN
cord-300872-blycbi4u	417	3	of	of	IN
cord-300872-blycbi4u	417	4	styrylquinolines	styrylquinoline	NNS
cord-300872-blycbi4u	417	5	with	with	IN
cord-300872-blycbi4u	417	6	various	various	JJ
cord-300872-blycbi4u	417	7	substituents	substituent	NNS
cord-300872-blycbi4u	417	8	was	be	VBD
cord-300872-blycbi4u	417	9	prepared	prepare	VBN
cord-300872-blycbi4u	417	10	as	as	IN
cord-300872-blycbi4u	417	11	shown	show	VBN
cord-300872-blycbi4u	417	12	in	in	IN
cord-300872-blycbi4u	417	13	Scheme	scheme	NN
cord-300872-blycbi4u	417	14	15	15	CD
cord-300872-blycbi4u	417	15	[	[	-LRB-
cord-300872-blycbi4u	417	16	39	39	CD
cord-300872-blycbi4u	417	17	]	]	-RRB-
cord-300872-blycbi4u	417	18	.	.	.
cord-300872-blycbi4u	418	1	In	in	IN
cord-300872-blycbi4u	418	2	the	the	DT
cord-300872-blycbi4u	418	3	first	first	JJ
cord-300872-blycbi4u	418	4	step	step	NN
cord-300872-blycbi4u	418	5	of	of	IN
cord-300872-blycbi4u	418	6	the	the	DT
cord-300872-blycbi4u	418	7	synthesis	synthesis	NN
cord-300872-blycbi4u	418	8	,	,	,
cord-300872-blycbi4u	418	9	the	the	DT
cord-300872-blycbi4u	418	10	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	418	11	group	group	NN
cord-300872-blycbi4u	418	12	in	in	IN
cord-300872-blycbi4u	418	13	58	58	CD
cord-300872-blycbi4u	418	14	was	be	VBD
cord-300872-blycbi4u	418	15	protected	protect	VBN
cord-300872-blycbi4u	418	16	by	by	IN
cord-300872-blycbi4u	418	17	conversion	conversion	NN
cord-300872-blycbi4u	418	18	into	into	IN
cord-300872-blycbi4u	418	19	the	the	DT
cord-300872-blycbi4u	418	20	acetyl	acetyl	NN
cord-300872-blycbi4u	418	21	analogue	analogue	NN
cord-300872-blycbi4u	418	22	59	59	CD
cord-300872-blycbi4u	418	23	.	.	.
cord-300872-blycbi4u	419	1	Then	then	RB
cord-300872-blycbi4u	419	2	,	,	,
cord-300872-blycbi4u	419	3	a	a	DT
cord-300872-blycbi4u	419	4	condensation	condensation	NN
cord-300872-blycbi4u	419	5	reaction	reaction	NN
cord-300872-blycbi4u	419	6	between	between	IN
cord-300872-blycbi4u	419	7	a	a	DT
cord-300872-blycbi4u	419	8	methyl	methyl	NN
cord-300872-blycbi4u	419	9	group	group	NN
cord-300872-blycbi4u	419	10	at	at	IN
cord-300872-blycbi4u	419	11	position	position	NN
cord-300872-blycbi4u	419	12	2	2	CD
cord-300872-blycbi4u	419	13	of	of	IN
cord-300872-blycbi4u	419	14	protected	protect	VBN
cord-300872-blycbi4u	419	15	8hydroxyquinoline	8hydroxyquinoline	CD
cord-300872-blycbi4u	419	16	and	and	CC
cord-300872-blycbi4u	419	17	appropriate	appropriate	JJ
cord-300872-blycbi4u	419	18	aromatic	aromatic	JJ
cord-300872-blycbi4u	419	19	aldehydes	aldehyde	NNS
cord-300872-blycbi4u	419	20	as	as	IN
cord-300872-blycbi4u	419	21	carried	carry	VBN
cord-300872-blycbi4u	419	22	out	out	RP
cord-300872-blycbi4u	419	23	using	use	VBG
cord-300872-blycbi4u	419	24	microwave	microwave	NN
cord-300872-blycbi4u	419	25	heating	heating	NN
cord-300872-blycbi4u	419	26	or	or	CC
cord-300872-blycbi4u	419	27	conventional	conventional	JJ
cord-300872-blycbi4u	419	28	procedures	procedure	NNS
cord-300872-blycbi4u	419	29	[	[	-LRB-
cord-300872-blycbi4u	419	30	40	40	CD
cord-300872-blycbi4u	419	31	]	]	-RRB-
cord-300872-blycbi4u	419	32	.	.	.
cord-300872-blycbi4u	420	1	Finally	finally	RB
cord-300872-blycbi4u	420	2	,	,	,
cord-300872-blycbi4u	420	3	deprotection	deprotection	NN
cord-300872-blycbi4u	420	4	of	of	IN
cord-300872-blycbi4u	420	5	the	the	DT
cord-300872-blycbi4u	420	6	acyl	acyl	NNP
cord-300872-blycbi4u	420	7	group	group	NN
cord-300872-blycbi4u	420	8	was	be	VBD
cord-300872-blycbi4u	420	9	achieved	achieve	VBN
cord-300872-blycbi4u	420	10	with	with	IN
cord-300872-blycbi4u	420	11	carbonate	carbonate	NN
cord-300872-blycbi4u	420	12	anion	anion	NN
cord-300872-blycbi4u	420	13	-	-	HYPH
cord-300872-blycbi4u	420	14	methanol	methanol	NN
cord-300872-blycbi4u	420	15	or	or	CC
cord-300872-blycbi4u	420	16	pyridine	pyridine	NN
cord-300872-blycbi4u	420	17	-	-	HYPH
cord-300872-blycbi4u	420	18	water	water	NN
cord-300872-blycbi4u	420	19	mixture	mixture	NN
cord-300872-blycbi4u	420	20	afforded	afford	VBD
cord-300872-blycbi4u	420	21	the	the	DT
cord-300872-blycbi4u	420	22	target	target	NN
cord-300872-blycbi4u	420	23	products	product	NNS
cord-300872-blycbi4u	420	24	60	60	CD
cord-300872-blycbi4u	420	25	.	.	.
cord-300872-blycbi4u	421	1	All	all	DT
cord-300872-blycbi4u	421	2	prepared	prepared	JJ
cord-300872-blycbi4u	421	3	compounds	compound	NNS
cord-300872-blycbi4u	421	4	were	be	VBD
cord-300872-blycbi4u	421	5	screened	screen	VBN
cord-300872-blycbi4u	421	6	for	for	IN
cord-300872-blycbi4u	421	7	anticancer	anticancer	JJ
cord-300872-blycbi4u	421	8	activity	activity	NN
cord-300872-blycbi4u	421	9	against	against	IN
cord-300872-blycbi4u	421	10	the	the	DT
cord-300872-blycbi4u	421	11	wild	wild	JJ
cord-300872-blycbi4u	421	12	-	-	HYPH
cord-300872-blycbi4u	421	13	type	type	NN
cord-300872-blycbi4u	421	14	HCT	hct	NN
cord-300872-blycbi4u	421	15	116	116	CD
cord-300872-blycbi4u	421	16	P53	P53	NNP
cord-300872-blycbi4u	421	17	+	+	CC
cord-300872-blycbi4u	422	1	/+	/+	.
cord-300872-blycbi4u	423	1	and	and	CC
cord-300872-blycbi4u	423	2	HCT	HCT	NNP
cord-300872-blycbi4u	423	3	116	116	CD
cord-300872-blycbi4u	423	4	P53	P53	NNP
cord-300872-blycbi4u	423	5	−/−	−/−	NNP
cord-300872-blycbi4u	423	6	cells	cell	NNS
cord-300872-blycbi4u	423	7	and	and	CC
cord-300872-blycbi4u	423	8	for	for	IN
cord-300872-blycbi4u	423	9	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	423	10	against	against	IN
cord-300872-blycbi4u	423	11	normal	normal	JJ
cord-300872-blycbi4u	423	12	cell	cell	NN
cord-300872-blycbi4u	423	13	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	423	14	.	.	.
cord-300872-blycbi4u	424	1	The	the	DT
cord-300872-blycbi4u	424	2	results	result	NNS
cord-300872-blycbi4u	424	3	revealed	reveal	VBD
cord-300872-blycbi4u	424	4	that	that	IN
cord-300872-blycbi4u	424	5	derivatives	derivative	NNS
cord-300872-blycbi4u	424	6	that	that	WDT
cord-300872-blycbi4u	424	7	have	have	VBP
cord-300872-blycbi4u	424	8	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	424	9	or	or	CC
cord-300872-blycbi4u	424	10	acyloxy	acyloxy	JJ
cord-300872-blycbi4u	424	11	groups	group	NNS
cord-300872-blycbi4u	424	12	at	at	IN
cord-300872-blycbi4u	424	13	position	position	NN
cord-300872-blycbi4u	424	14	8	8	CD
cord-300872-blycbi4u	424	15	of	of	IN
cord-300872-blycbi4u	424	16	the	the	DT
cord-300872-blycbi4u	424	17	quinolone	quinolone	NNP
cord-300872-blycbi4u	424	18	moiety	moiety	NNP
cord-300872-blycbi4u	424	19	exhibit	exhibit	VB
cord-300872-blycbi4u	424	20	moderate	moderate	JJ
cord-300872-blycbi4u	424	21	activities	activity	NNS
cord-300872-blycbi4u	424	22	(	(	-LRB-
cord-300872-blycbi4u	424	23	4.60	4.60	CD
cord-300872-blycbi4u	424	24	-	-	SYM
cord-300872-blycbi4u	424	25	25.00	25.00	CD
cord-300872-blycbi4u	424	26	mM	mm	CD
cord-300872-blycbi4u	424	27	)	)	-RRB-
cord-300872-blycbi4u	424	28	and	and	CC
cord-300872-blycbi4u	424	29	(	(	-LRB-
cord-300872-blycbi4u	424	30	2.61	2.61	CD
cord-300872-blycbi4u	424	31	-	-	SYM
cord-300872-blycbi4u	424	32	25.00	25.00	CD
cord-300872-blycbi4u	424	33	mM	mm	CD
cord-300872-blycbi4u	424	34	)	)	-RRB-
cord-300872-blycbi4u	424	35	towards	towards	IN
cord-300872-blycbi4u	424	36	P53	P53	NNP
cord-300872-blycbi4u	424	37	+	+	CC
cord-300872-blycbi4u	424	38	/+	/+	.
cord-300872-blycbi4u	425	1	and	and	CC
cord-300872-blycbi4u	425	2	P53	P53	NNP
cord-300872-blycbi4u	425	3	−/−	−/−	NNP
cord-300872-blycbi4u	425	4	,	,	,
cord-300872-blycbi4u	425	5	respectively	respectively	RB
cord-300872-blycbi4u	425	6	.	.	.
cord-300872-blycbi4u	426	1	Analogues	analogue	NNS
cord-300872-blycbi4u	426	2	that	that	WDT
cord-300872-blycbi4u	426	3	were	be	VBD
cord-300872-blycbi4u	426	4	based	base	VBN
cord-300872-blycbi4u	426	5	on	on	IN
cord-300872-blycbi4u	426	6	dichloroquinone	dichloroquinone	NNP
cord-300872-blycbi4u	426	7	and	and	CC
cord-300872-blycbi4u	426	8	oxyacyl	oxyacyl	NNP
cord-300872-blycbi4u	426	9	groups	group	NNS
cord-300872-blycbi4u	426	10	were	be	VBD
cord-300872-blycbi4u	426	11	the	the	DT
cord-300872-blycbi4u	426	12	most	most	RBS
cord-300872-blycbi4u	426	13	active	active	JJ
cord-300872-blycbi4u	426	14	in	in	IN
cord-300872-blycbi4u	426	15	this	this	DT
cord-300872-blycbi4u	426	16	series	series	NN
cord-300872-blycbi4u	426	17	towards	towards	IN
cord-300872-blycbi4u	426	18	P53	P53	NNP
cord-300872-blycbi4u	426	19	+	+	CC
cord-300872-blycbi4u	426	20	/+	/+	.
cord-300872-blycbi4u	427	1	and	and	CC
cord-300872-blycbi4u	427	2	P53	P53	NNP
cord-300872-blycbi4u	427	3	−/−	−/−	NNP
cord-300872-blycbi4u	427	4	(	(	-LRB-
cord-300872-blycbi4u	427	5	0	0	NFP
cord-300872-blycbi4u	427	6	.	.	.
cord-300872-blycbi4u	428	1	28	28	CD
cord-300872-blycbi4u	428	2	-	-	SYM
cord-300872-blycbi4u	428	3	13.85	13.85	CD
cord-300872-blycbi4u	428	4	[	[	-LRB-
cord-300872-blycbi4u	428	5	41	41	CD
cord-300872-blycbi4u	428	6	]	]	-RRB-
cord-300872-blycbi4u	428	7	.	.	.
cord-300872-blycbi4u	429	1	Their	-PRON-	PRP$
cord-300872-blycbi4u	429	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	429	3	procedure	procedure	NN
cord-300872-blycbi4u	429	4	involved	involve	VBD
cord-300872-blycbi4u	429	5	a	a	DT
cord-300872-blycbi4u	429	6	Knoevenagel	Knoevenagel	NNP
cord-300872-blycbi4u	429	7	condensation	condensation	NN
cord-300872-blycbi4u	429	8	between	between	IN
cord-300872-blycbi4u	429	9	malonitrile	malonitrile	NNP
cord-300872-blycbi4u	429	10	(	(	-LRB-
cord-300872-blycbi4u	429	11	61	61	CD
cord-300872-blycbi4u	429	12	)	)	-RRB-
cord-300872-blycbi4u	429	13	and	and	CC
cord-300872-blycbi4u	429	14	the	the	DT
cord-300872-blycbi4u	429	15	respective	respective	JJ
cord-300872-blycbi4u	429	16	aryl	aryl	NN
cord-300872-blycbi4u	429	17	aldehyde	aldehyde	NN
cord-300872-blycbi4u	429	18	62	62	CD
cord-300872-blycbi4u	429	19	to	to	TO
cord-300872-blycbi4u	429	20	afford	afford	VB
cord-300872-blycbi4u	429	21	the	the	DT
cord-300872-blycbi4u	429	22	corresponding	correspond	VBG
cord-300872-blycbi4u	429	23	arylidene	arylidene	JJ
cord-300872-blycbi4u	429	24	-	-	HYPH
cord-300872-blycbi4u	429	25	malonitrile	malonitrile	NNP
cord-300872-blycbi4u	429	26	intermediates	intermediate	NNS
cord-300872-blycbi4u	429	27	63	63	CD
cord-300872-blycbi4u	429	28	,	,	,
cord-300872-blycbi4u	429	29	as	as	IN
cord-300872-blycbi4u	429	30	shown	show	VBN
cord-300872-blycbi4u	429	31	in	in	IN
cord-300872-blycbi4u	429	32	Scheme	Scheme	NNP
cord-300872-blycbi4u	429	33	16	16	CD
cord-300872-blycbi4u	429	34	.	.	.
cord-300872-blycbi4u	430	1	Then	then	RB
cord-300872-blycbi4u	430	2	,	,	,
cord-300872-blycbi4u	430	3	the	the	DT
cord-300872-blycbi4u	430	4	phenolate	phenolate	NN
cord-300872-blycbi4u	430	5	anion	anion	NN
cord-300872-blycbi4u	430	6	attacks	attack	VBZ
cord-300872-blycbi4u	430	7	the	the	DT
cord-300872-blycbi4u	430	8	β	β	NN
cord-300872-blycbi4u	430	9	-	-	HYPH
cord-300872-blycbi4u	430	10	carbon	carbon	NN
cord-300872-blycbi4u	430	11	via	via	IN
cord-300872-blycbi4u	430	12	C-7	C-7	NNP
cord-300872-blycbi4u	430	13	to	to	TO
cord-300872-blycbi4u	430	14	produce	produce	VB
cord-300872-blycbi4u	430	15	an	an	DT
cord-300872-blycbi4u	430	16	acyclic	acyclic	JJ
cord-300872-blycbi4u	430	17	Michael	Michael	NNP
cord-300872-blycbi4u	430	18	adduct	adduct	NN
cord-300872-blycbi4u	430	19	,	,	,
cord-300872-blycbi4u	430	20	which	which	WDT
cord-300872-blycbi4u	430	21	undergoes	undergo	VBZ
cord-300872-blycbi4u	430	22	cyclization	cyclization	NN
cord-300872-blycbi4u	430	23	reaction	reaction	NN
cord-300872-blycbi4u	430	24	(	(	-LRB-
cord-300872-blycbi4u	430	25	6-exo	6-exo	CD
cord-300872-blycbi4u	430	26	-	-	HYPH
cord-300872-blycbi4u	430	27	dig	dig	NN
cord-300872-blycbi4u	430	28	)	)	-RRB-
cord-300872-blycbi4u	430	29	and	and	CC
cord-300872-blycbi4u	430	30	tautomerization	tautomerization	NN
cord-300872-blycbi4u	430	31	to	to	TO
cord-300872-blycbi4u	430	32	afford	afford	VB
cord-300872-blycbi4u	430	33	the	the	DT
cord-300872-blycbi4u	430	34	target	target	NN
cord-300872-blycbi4u	430	35	product	product	NN
cord-300872-blycbi4u	430	36	64	64	CD
cord-300872-blycbi4u	430	37	.	.	.
cord-300872-blycbi4u	431	1	All	all	DT
cord-300872-blycbi4u	431	2	prepared	prepared	JJ
cord-300872-blycbi4u	431	3	derivatives	derivative	NNS
cord-300872-blycbi4u	431	4	in	in	IN
cord-300872-blycbi4u	431	5	the	the	DT
cord-300872-blycbi4u	431	6	study	study	NN
cord-300872-blycbi4u	431	7	(	(	-LRB-
cord-300872-blycbi4u	431	8	along	along	IN
cord-300872-blycbi4u	431	9	with	with	IN
cord-300872-blycbi4u	431	10	compound	compound	NN
cord-300872-blycbi4u	431	11	LY290181	ly290181	NN
cord-300872-blycbi4u	431	12	used	use	VBN
cord-300872-blycbi4u	431	13	as	as	IN
cord-300872-blycbi4u	431	14	the	the	DT
cord-300872-blycbi4u	431	15	standard	standard	NN
cord-300872-blycbi4u	431	16	)	)	-RRB-
cord-300872-blycbi4u	431	17	have	have	VBP
cord-300872-blycbi4u	431	18	been	be	VBN
cord-300872-blycbi4u	431	19	tested	test	VBN
cord-300872-blycbi4u	431	20	against	against	IN
cord-300872-blycbi4u	431	21	various	various	JJ
cord-300872-blycbi4u	431	22	cancer	cancer	NN
cord-300872-blycbi4u	431	23	cell	cell	NN
cord-300872-blycbi4u	431	24	lines	line	NNS
cord-300872-blycbi4u	431	25	,	,	,
cord-300872-blycbi4u	431	26	namely	namely	RB
cord-300872-blycbi4u	431	27	pancreatic	pancreatic	JJ
cord-300872-blycbi4u	431	28	carcinoma	carcinoma	NN
cord-300872-blycbi4u	431	29	518A	518A	NNP
cord-300872-blycbi4u	431	30	,	,	,
cord-300872-blycbi4u	431	31	colon	colon	NN
cord-300872-blycbi4u	431	32	carcinoma	carcinoma	NN
cord-300872-blycbi4u	431	33	cells	cell	NNS
cord-300872-blycbi4u	431	34	HT-29	HT-29	NNP
cord-300872-blycbi4u	431	35	,	,	,
cord-300872-blycbi4u	431	36	DLD-1	DLD-1	NNP
cord-300872-blycbi4u	431	37	,	,	,
cord-300872-blycbi4u	431	38	HCT	HCT	NNP
cord-300872-blycbi4u	431	39	116	116	CD
cord-300872-blycbi4u	431	40	,	,	,
cord-300872-blycbi4u	431	41	cervix	cervix	NN
cord-300872-blycbi4u	431	42	carcinoma	carcinoma	NN
cord-300872-blycbi4u	431	43	KB	KB	NNP
cord-300872-blycbi4u	431	44	-	-	HYPH
cord-300872-blycbi4u	431	45	V1	V1	NNP
cord-300872-blycbi4u	431	46	Vbl	Vbl	NNP
cord-300872-blycbi4u	431	47	,	,	,
cord-300872-blycbi4u	431	48	and	and	CC
cord-300872-blycbi4u	431	49	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	431	50	Tobo	tobo	JJ
cord-300872-blycbi4u	431	51	breast	breast	NN
cord-300872-blycbi4u	431	52	carcinoma	carcinoma	NN
cord-300872-blycbi4u	431	53	cell	cell	NN
cord-300872-blycbi4u	431	54	lines	line	NNS
cord-300872-blycbi4u	431	55	,	,	,
cord-300872-blycbi4u	431	56	in	in	IN
cord-300872-blycbi4u	431	57	addition	addition	NN
cord-300872-blycbi4u	431	58	to	to	IN
cord-300872-blycbi4u	431	59	non	non	JJ
cord-300872-blycbi4u	431	60	-	-	JJ
cord-300872-blycbi4u	431	61	malignant	malignant	JJ
cord-300872-blycbi4u	431	62	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	431	63	.	.	.
cord-300872-blycbi4u	432	1	The	the	DT
cord-300872-blycbi4u	432	2	results	result	NNS
cord-300872-blycbi4u	432	3	revealed	reveal	VBD
cord-300872-blycbi4u	432	4	that	that	IN
cord-300872-blycbi4u	432	5	that	that	IN
cord-300872-blycbi4u	432	6	these	these	DT
cord-300872-blycbi4u	432	7	derivatives	derivative	NNS
cord-300872-blycbi4u	432	8	exhibit	exhibit	VBP
cord-300872-blycbi4u	432	9	remarkable	remarkable	JJ
cord-300872-blycbi4u	432	10	activities	activity	NNS
cord-300872-blycbi4u	432	11	,	,	,
cord-300872-blycbi4u	432	12	with	with	IN
cord-300872-blycbi4u	432	13	IC	IC	NNP
cord-300872-blycbi4u	432	14	50	50	CD
cord-300872-blycbi4u	432	15	values	value	NNS
cord-300872-blycbi4u	432	16	in	in	IN
cord-300872-blycbi4u	432	17	nanomolar	nanomolar	NNP
cord-300872-blycbi4u	432	18	concentrations	concentration	NNS
cord-300872-blycbi4u	432	19	,	,	,
cord-300872-blycbi4u	432	20	meaning	mean	VBG
cord-300872-blycbi4u	432	21	these	these	DT
cord-300872-blycbi4u	432	22	results	result	NNS
cord-300872-blycbi4u	432	23	are	be	VBP
cord-300872-blycbi4u	432	24	even	even	RB
cord-300872-blycbi4u	432	25	better	well	JJR
cord-300872-blycbi4u	432	26	than	than	IN
cord-300872-blycbi4u	432	27	the	the	DT
cord-300872-blycbi4u	432	28	activity	activity	NN
cord-300872-blycbi4u	432	29	of	of	IN
cord-300872-blycbi4u	432	30	LY290181	ly290181	NN
cord-300872-blycbi4u	432	31	.	.	.
cord-300872-blycbi4u	433	1	Two	two	CD
cord-300872-blycbi4u	433	2	compounds	compound	NNS
cord-300872-blycbi4u	433	3	designated	designate	VBN
cord-300872-blycbi4u	433	4	with	with	IN
cord-300872-blycbi4u	433	5	R	r	NN
cord-300872-blycbi4u	433	6	=	=	SYM
cord-300872-blycbi4u	433	7	CH	CH	NNP
cord-300872-blycbi4u	433	8	3	3	CD
cord-300872-blycbi4u	433	9	,	,	,
cord-300872-blycbi4u	433	10	R	r	NN
cord-300872-blycbi4u	433	11	1	1	CD
cord-300872-blycbi4u	433	12	=	=	NFP
cord-300872-blycbi4u	434	1	R	r	NN
cord-300872-blycbi4u	434	2	3	3	CD
cord-300872-blycbi4u	434	3	=	=	NFP
cord-300872-blycbi4u	435	1	H	h	NN
cord-300872-blycbi4u	435	2	,	,	,
cord-300872-blycbi4u	435	3	R	r	NN
cord-300872-blycbi4u	435	4	2	2	CD
cord-300872-blycbi4u	435	5	=	=	NFP
cord-300872-blycbi4u	436	1	R	r	NN
cord-300872-blycbi4u	436	2	4	4	CD
cord-300872-blycbi4u	436	3	=	=	NFP
cord-300872-blycbi4u	437	1	F	F	NNP
cord-300872-blycbi4u	437	2	and	and	CC
cord-300872-blycbi4u	437	3	R	r	NN
cord-300872-blycbi4u	437	4	=	=	SYM
cord-300872-blycbi4u	437	5	CH	CH	NNP
cord-300872-blycbi4u	437	6	3	3	CD
cord-300872-blycbi4u	437	7	,	,	,
cord-300872-blycbi4u	437	8	R	r	NN
cord-300872-blycbi4u	437	9	1	1	CD
cord-300872-blycbi4u	438	1	=	=	NFP
cord-300872-blycbi4u	439	1	R	r	NN
cord-300872-blycbi4u	439	2	3	3	CD
cord-300872-blycbi4u	439	3	=	=	NFP
cord-300872-blycbi4u	440	1	R	r	NN
cord-300872-blycbi4u	440	2	4	4	CD
cord-300872-blycbi4u	440	3	=	=	NFP
cord-300872-blycbi4u	441	1	H	h	NN
cord-300872-blycbi4u	441	2	,	,	,
cord-300872-blycbi4u	441	3	R	r	NN
cord-300872-blycbi4u	441	4	2	2	CD
cord-300872-blycbi4u	442	1	=	=	NFP
cord-300872-blycbi4u	443	1	NO	no	DT
cord-300872-blycbi4u	443	2	2	2	CD
cord-300872-blycbi4u	443	3	were	be	VBD
cord-300872-blycbi4u	443	4	the	the	DT
cord-300872-blycbi4u	443	5	most	most	RBS
cord-300872-blycbi4u	443	6	active	active	JJ
cord-300872-blycbi4u	443	7	among	among	IN
cord-300872-blycbi4u	443	8	all	all	DT
cord-300872-blycbi4u	443	9	examined	examine	VBN
cord-300872-blycbi4u	443	10	molecules	molecule	NNS
cord-300872-blycbi4u	443	11	.	.	.
cord-300872-blycbi4u	444	1	The	the	DT
cord-300872-blycbi4u	444	2	first	first	JJ
cord-300872-blycbi4u	444	3	one	one	NN
cord-300872-blycbi4u	444	4	had	have	VBD
cord-300872-blycbi4u	444	5	IC	IC	NNP
cord-300872-blycbi4u	444	6	50	50	CD
cord-300872-blycbi4u	444	7	values	value	NNS
cord-300872-blycbi4u	444	8	of	of	IN
cord-300872-blycbi4u	444	9	20.1	20.1	CD
cord-300872-blycbi4u	444	10	and	and	CC
cord-300872-blycbi4u	444	11	14	14	CD
cord-300872-blycbi4u	444	12	nM	nm	NN
cord-300872-blycbi4u	444	13	against	against	IN
cord-300872-blycbi4u	444	14	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	444	15	and	and	CC
cord-300872-blycbi4u	444	16	KB	KB	NNP
cord-300872-blycbi4u	444	17	-	-	HYPH
cord-300872-blycbi4u	444	18	V1	V1	NNP
cord-300872-blycbi4u	444	19	Vbl	Vbl	NNP
cord-300872-blycbi4u	444	20	,	,	,
cord-300872-blycbi4u	444	21	respectively	respectively	RB
cord-300872-blycbi4u	444	22	.	.	.
cord-300872-blycbi4u	445	1	On	on	IN
cord-300872-blycbi4u	445	2	the	the	DT
cord-300872-blycbi4u	445	3	other	other	JJ
cord-300872-blycbi4u	445	4	hand	hand	NN
cord-300872-blycbi4u	445	5	,	,	,
cord-300872-blycbi4u	445	6	the	the	DT
cord-300872-blycbi4u	445	7	second	second	JJ
cord-300872-blycbi4u	445	8	compound	compound	NN
cord-300872-blycbi4u	445	9	had	have	VBD
cord-300872-blycbi4u	445	10	an	an	DT
cord-300872-blycbi4u	445	11	IC	IC	NNP
cord-300872-blycbi4u	445	12	50	50	CD
cord-300872-blycbi4u	445	13	value	value	NN
cord-300872-blycbi4u	445	14	of	of	IN
cord-300872-blycbi4u	445	15	20	20	CD
cord-300872-blycbi4u	445	16	nM	nm	NN
cord-300872-blycbi4u	445	17	against	against	IN
cord-300872-blycbi4u	445	18	KB	KB	NNP
cord-300872-blycbi4u	445	19	-	-	HYPH
cord-300872-blycbi4u	445	20	V1	V1	NNP
cord-300872-blycbi4u	445	21	Vbl	Vbl	NNP
cord-300872-blycbi4u	445	22	,	,	,
cord-300872-blycbi4u	445	23	which	which	WDT
cord-300872-blycbi4u	445	24	is	be	VBZ
cord-300872-blycbi4u	445	25	even	even	RB
cord-300872-blycbi4u	445	26	better	well	JJR
cord-300872-blycbi4u	445	27	than	than	IN
cord-300872-blycbi4u	445	28	the	the	DT
cord-300872-blycbi4u	445	29	reference	reference	NN
cord-300872-blycbi4u	445	30	.	.	.
cord-300872-blycbi4u	446	1	In	in	IN
cord-300872-blycbi4u	446	2	this	this	DT
cord-300872-blycbi4u	446	3	regard	regard	NN
cord-300872-blycbi4u	446	4	,	,	,
cord-300872-blycbi4u	446	5	it	-PRON-	PRP
cord-300872-blycbi4u	446	6	is	be	VBZ
cord-300872-blycbi4u	446	7	worth	worth	JJ
cord-300872-blycbi4u	446	8	mentioning	mention	VBG
cord-300872-blycbi4u	446	9	that	that	IN
cord-300872-blycbi4u	446	10	the	the	DT
cord-300872-blycbi4u	446	11	mechanism	mechanism	NN
cord-300872-blycbi4u	446	12	of	of	IN
cord-300872-blycbi4u	446	13	action	action	NN
cord-300872-blycbi4u	446	14	of	of	IN
cord-300872-blycbi4u	446	15	these	these	DT
cord-300872-blycbi4u	446	16	compounds	compound	NNS
cord-300872-blycbi4u	446	17	may	may	MD
cord-300872-blycbi4u	446	18	be	be	VB
cord-300872-blycbi4u	446	19	associated	associate	VBN
cord-300872-blycbi4u	446	20	with	with	IN
cord-300872-blycbi4u	446	21	tubulin	tubulin	JJ
cord-300872-blycbi4u	446	22	polymerization	polymerization	NN
cord-300872-blycbi4u	446	23	interference	interference	NN
cord-300872-blycbi4u	446	24	and	and	CC
cord-300872-blycbi4u	446	25	ROS	ROS	NNP
cord-300872-blycbi4u	446	26	formation	formation	NN
cord-300872-blycbi4u	446	27	,	,	,
cord-300872-blycbi4u	446	28	in	in	IN
cord-300872-blycbi4u	446	29	which	which	WDT
cord-300872-blycbi4u	446	30	the	the	DT
cord-300872-blycbi4u	446	31	molecule	molecule	NN
cord-300872-blycbi4u	446	32	-	-	HYPH
cord-300872-blycbi4u	446	33	induced	induce	VBN
cord-300872-blycbi4u	446	34	ROS	ROS	NNP
cord-300872-blycbi4u	446	35	generation	generation	NN
cord-300872-blycbi4u	446	36	could	could	MD
cord-300872-blycbi4u	446	37	be	be	VB
cord-300872-blycbi4u	446	38	responsible	responsible	JJ
cord-300872-blycbi4u	446	39	for	for	IN
cord-300872-blycbi4u	446	40	their	-PRON-	PRP$
cord-300872-blycbi4u	446	41	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	446	42	,	,	,
cord-300872-blycbi4u	446	43	since	since	IN
cord-300872-blycbi4u	446	44	ROS	ROS	NNP
cord-300872-blycbi4u	446	45	overproduction	overproduction	NN
cord-300872-blycbi4u	446	46	may	may	MD
cord-300872-blycbi4u	446	47	induce	induce	VB
cord-300872-blycbi4u	446	48	endoplasmic	endoplasmic	NN
cord-300872-blycbi4u	446	49	reticulum	reticulum	NN
cord-300872-blycbi4u	446	50	stress	stress	NN
cord-300872-blycbi4u	446	51	.	.	.
cord-300872-blycbi4u	447	1	All	all	DT
cord-300872-blycbi4u	447	2	prepared	prepared	JJ
cord-300872-blycbi4u	447	3	compounds	compound	NNS
cord-300872-blycbi4u	447	4	were	be	VBD
cord-300872-blycbi4u	447	5	screened	screen	VBN
cord-300872-blycbi4u	447	6	for	for	IN
cord-300872-blycbi4u	447	7	anticancer	anticancer	JJ
cord-300872-blycbi4u	447	8	activity	activity	NN
cord-300872-blycbi4u	447	9	against	against	IN
cord-300872-blycbi4u	447	10	the	the	DT
cord-300872-blycbi4u	447	11	wild	wild	JJ
cord-300872-blycbi4u	447	12	-	-	HYPH
cord-300872-blycbi4u	447	13	type	type	NN
cord-300872-blycbi4u	447	14	HCT	hct	NN
cord-300872-blycbi4u	447	15	116	116	CD
cord-300872-blycbi4u	447	16	P53	P53	NNP
cord-300872-blycbi4u	447	17	+	+	CC
cord-300872-blycbi4u	448	1	/+	/+	.
cord-300872-blycbi4u	449	1	and	and	CC
cord-300872-blycbi4u	449	2	HCT	HCT	NNP
cord-300872-blycbi4u	449	3	116	116	CD
cord-300872-blycbi4u	449	4	P53	P53	NNP
cord-300872-blycbi4u	449	5	−/−	−/−	NNP
cord-300872-blycbi4u	449	6	cells	cell	NNS
cord-300872-blycbi4u	449	7	and	and	CC
cord-300872-blycbi4u	449	8	for	for	IN
cord-300872-blycbi4u	449	9	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	449	10	against	against	IN
cord-300872-blycbi4u	449	11	normal	normal	JJ
cord-300872-blycbi4u	449	12	cell	cell	NN
cord-300872-blycbi4u	449	13	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	449	14	.	.	.
cord-300872-blycbi4u	450	1	The	the	DT
cord-300872-blycbi4u	450	2	results	result	NNS
cord-300872-blycbi4u	450	3	revealed	reveal	VBD
cord-300872-blycbi4u	450	4	that	that	IN
cord-300872-blycbi4u	450	5	derivatives	derivative	NNS
cord-300872-blycbi4u	450	6	that	that	WDT
cord-300872-blycbi4u	450	7	have	have	VBP
cord-300872-blycbi4u	450	8	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	450	9	or	or	CC
cord-300872-blycbi4u	450	10	acyloxy	acyloxy	JJ
cord-300872-blycbi4u	450	11	groups	group	NNS
cord-300872-blycbi4u	450	12	at	at	IN
cord-300872-blycbi4u	450	13	position	position	NN
cord-300872-blycbi4u	450	14	8	8	CD
cord-300872-blycbi4u	450	15	of	of	IN
cord-300872-blycbi4u	450	16	the	the	DT
cord-300872-blycbi4u	450	17	quinolone	quinolone	NNP
cord-300872-blycbi4u	450	18	moiety	moiety	NNP
cord-300872-blycbi4u	450	19	exhibit	exhibit	VB
cord-300872-blycbi4u	450	20	moderate	moderate	JJ
cord-300872-blycbi4u	450	21	activities	activity	NNS
cord-300872-blycbi4u	450	22	(	(	-LRB-
cord-300872-blycbi4u	450	23	4.60	4.60	CD
cord-300872-blycbi4u	450	24	-	-	SYM
cord-300872-blycbi4u	450	25	25.00	25.00	CD
cord-300872-blycbi4u	450	26	mM	mm	CD
cord-300872-blycbi4u	450	27	)	)	-RRB-
cord-300872-blycbi4u	450	28	and	and	CC
cord-300872-blycbi4u	450	29	(	(	-LRB-
cord-300872-blycbi4u	450	30	2.61	2.61	CD
cord-300872-blycbi4u	450	31	-	-	SYM
cord-300872-blycbi4u	450	32	25.00	25.00	CD
cord-300872-blycbi4u	450	33	mM	mm	CD
cord-300872-blycbi4u	450	34	)	)	-RRB-
cord-300872-blycbi4u	450	35	towards	towards	IN
cord-300872-blycbi4u	450	36	P53	P53	NNP
cord-300872-blycbi4u	450	37	+	+	CC
cord-300872-blycbi4u	450	38	/+	/+	.
cord-300872-blycbi4u	451	1	and	and	CC
cord-300872-blycbi4u	451	2	P53	P53	NNP
cord-300872-blycbi4u	451	3	−/−	−/−	NNP
cord-300872-blycbi4u	451	4	,	,	,
cord-300872-blycbi4u	451	5	respectively	respectively	RB
cord-300872-blycbi4u	451	6	.	.	.
cord-300872-blycbi4u	452	1	Analogues	analogue	NNS
cord-300872-blycbi4u	452	2	that	that	WDT
cord-300872-blycbi4u	452	3	were	be	VBD
cord-300872-blycbi4u	452	4	based	base	VBN
cord-300872-blycbi4u	452	5	on	on	IN
cord-300872-blycbi4u	452	6	dichloroquinone	dichloroquinone	NNP
cord-300872-blycbi4u	452	7	and	and	CC
cord-300872-blycbi4u	452	8	oxyacyl	oxyacyl	NNP
cord-300872-blycbi4u	452	9	groups	group	NNS
cord-300872-blycbi4u	452	10	were	be	VBD
cord-300872-blycbi4u	452	11	the	the	DT
cord-300872-blycbi4u	452	12	most	most	RBS
cord-300872-blycbi4u	452	13	active	active	JJ
cord-300872-blycbi4u	452	14	in	in	IN
cord-300872-blycbi4u	452	15	this	this	DT
cord-300872-blycbi4u	452	16	series	series	NN
cord-300872-blycbi4u	452	17	towards	towards	IN
cord-300872-blycbi4u	452	18	P53	P53	NNP
cord-300872-blycbi4u	452	19	+	+	CC
cord-300872-blycbi4u	452	20	/+	/+	.
cord-300872-blycbi4u	453	1	and	and	CC
cord-300872-blycbi4u	453	2	P53	P53	NNP
cord-300872-blycbi4u	453	3	−/−	−/−	NNP
cord-300872-blycbi4u	453	4	(	(	-LRB-
cord-300872-blycbi4u	453	5	0	0	NFP
cord-300872-blycbi4u	453	6	.	.	.
cord-300872-blycbi4u	454	1	28	28	CD
cord-300872-blycbi4u	454	2	-	-	SYM
cord-300872-blycbi4u	454	3	13.85	13.85	CD
cord-300872-blycbi4u	454	4	[	[	-LRB-
cord-300872-blycbi4u	454	5	41	41	CD
cord-300872-blycbi4u	454	6	]	]	-RRB-
cord-300872-blycbi4u	454	7	.	.	.
cord-300872-blycbi4u	455	1	Their	-PRON-	PRP$
cord-300872-blycbi4u	455	2	synthetic	synthetic	JJ
cord-300872-blycbi4u	455	3	procedure	procedure	NN
cord-300872-blycbi4u	455	4	involved	involve	VBD
cord-300872-blycbi4u	455	5	a	a	DT
cord-300872-blycbi4u	455	6	Knoevenagel	Knoevenagel	NNP
cord-300872-blycbi4u	455	7	condensation	condensation	NN
cord-300872-blycbi4u	455	8	between	between	IN
cord-300872-blycbi4u	455	9	malonitrile	malonitrile	NNP
cord-300872-blycbi4u	455	10	(	(	-LRB-
cord-300872-blycbi4u	455	11	61	61	CD
cord-300872-blycbi4u	455	12	)	)	-RRB-
cord-300872-blycbi4u	455	13	and	and	CC
cord-300872-blycbi4u	455	14	the	the	DT
cord-300872-blycbi4u	455	15	respective	respective	JJ
cord-300872-blycbi4u	455	16	aryl	aryl	NN
cord-300872-blycbi4u	455	17	aldehyde	aldehyde	NN
cord-300872-blycbi4u	455	18	62	62	CD
cord-300872-blycbi4u	455	19	to	to	TO
cord-300872-blycbi4u	455	20	afford	afford	VB
cord-300872-blycbi4u	455	21	the	the	DT
cord-300872-blycbi4u	455	22	corresponding	correspond	VBG
cord-300872-blycbi4u	455	23	arylidene	arylidene	JJ
cord-300872-blycbi4u	455	24	-	-	HYPH
cord-300872-blycbi4u	455	25	malonitrile	malonitrile	NNP
cord-300872-blycbi4u	455	26	intermediates	intermediate	NNS
cord-300872-blycbi4u	455	27	63	63	CD
cord-300872-blycbi4u	455	28	,	,	,
cord-300872-blycbi4u	455	29	as	as	IN
cord-300872-blycbi4u	455	30	shown	show	VBN
cord-300872-blycbi4u	455	31	in	in	IN
cord-300872-blycbi4u	455	32	Scheme	Scheme	NNP
cord-300872-blycbi4u	455	33	16	16	CD
cord-300872-blycbi4u	455	34	.	.	.
cord-300872-blycbi4u	456	1	Then	then	RB
cord-300872-blycbi4u	456	2	,	,	,
cord-300872-blycbi4u	456	3	the	the	DT
cord-300872-blycbi4u	456	4	phenolate	phenolate	NN
cord-300872-blycbi4u	456	5	anion	anion	NN
cord-300872-blycbi4u	456	6	attacks	attack	VBZ
cord-300872-blycbi4u	456	7	the	the	DT
cord-300872-blycbi4u	456	8	β	β	NN
cord-300872-blycbi4u	456	9	-	-	HYPH
cord-300872-blycbi4u	456	10	carbon	carbon	NN
cord-300872-blycbi4u	456	11	via	via	IN
cord-300872-blycbi4u	456	12	C-7	C-7	NNP
cord-300872-blycbi4u	456	13	to	to	TO
cord-300872-blycbi4u	456	14	produce	produce	VB
cord-300872-blycbi4u	456	15	an	an	DT
cord-300872-blycbi4u	456	16	acyclic	acyclic	JJ
cord-300872-blycbi4u	456	17	Michael	Michael	NNP
cord-300872-blycbi4u	456	18	adduct	adduct	NN
cord-300872-blycbi4u	456	19	,	,	,
cord-300872-blycbi4u	456	20	which	which	WDT
cord-300872-blycbi4u	456	21	undergoes	undergo	VBZ
cord-300872-blycbi4u	456	22	cyclization	cyclization	NN
cord-300872-blycbi4u	456	23	reaction	reaction	NN
cord-300872-blycbi4u	456	24	(	(	-LRB-
cord-300872-blycbi4u	456	25	6-exo	6-exo	CD
cord-300872-blycbi4u	456	26	-	-	HYPH
cord-300872-blycbi4u	456	27	dig	dig	NN
cord-300872-blycbi4u	456	28	)	)	-RRB-
cord-300872-blycbi4u	456	29	and	and	CC
cord-300872-blycbi4u	456	30	tautomerization	tautomerization	NN
cord-300872-blycbi4u	456	31	to	to	TO
cord-300872-blycbi4u	456	32	afford	afford	VB
cord-300872-blycbi4u	456	33	the	the	DT
cord-300872-blycbi4u	456	34	target	target	NN
cord-300872-blycbi4u	456	35	product	product	NN
cord-300872-blycbi4u	456	36	64	64	CD
cord-300872-blycbi4u	456	37	.	.	.
cord-300872-blycbi4u	457	1	All	all	DT
cord-300872-blycbi4u	457	2	prepared	prepared	JJ
cord-300872-blycbi4u	457	3	derivatives	derivative	NNS
cord-300872-blycbi4u	457	4	in	in	IN
cord-300872-blycbi4u	457	5	the	the	DT
cord-300872-blycbi4u	457	6	study	study	NN
cord-300872-blycbi4u	457	7	(	(	-LRB-
cord-300872-blycbi4u	457	8	along	along	IN
cord-300872-blycbi4u	457	9	with	with	IN
cord-300872-blycbi4u	457	10	compound	compound	NN
cord-300872-blycbi4u	457	11	LY290181	ly290181	NN
cord-300872-blycbi4u	457	12	used	use	VBN
cord-300872-blycbi4u	457	13	as	as	IN
cord-300872-blycbi4u	457	14	the	the	DT
cord-300872-blycbi4u	457	15	standard	standard	NN
cord-300872-blycbi4u	457	16	)	)	-RRB-
cord-300872-blycbi4u	457	17	have	have	VBP
cord-300872-blycbi4u	457	18	been	be	VBN
cord-300872-blycbi4u	457	19	tested	test	VBN
cord-300872-blycbi4u	457	20	against	against	IN
cord-300872-blycbi4u	457	21	various	various	JJ
cord-300872-blycbi4u	457	22	cancer	cancer	NN
cord-300872-blycbi4u	457	23	cell	cell	NN
cord-300872-blycbi4u	457	24	lines	line	NNS
cord-300872-blycbi4u	457	25	,	,	,
cord-300872-blycbi4u	457	26	namely	namely	RB
cord-300872-blycbi4u	457	27	pancreatic	pancreatic	JJ
cord-300872-blycbi4u	457	28	carcinoma	carcinoma	NN
cord-300872-blycbi4u	457	29	518A	518A	NNP
cord-300872-blycbi4u	457	30	,	,	,
cord-300872-blycbi4u	457	31	colon	colon	NN
cord-300872-blycbi4u	457	32	carcinoma	carcinoma	NN
cord-300872-blycbi4u	457	33	cells	cell	NNS
cord-300872-blycbi4u	457	34	HT-29	HT-29	NNP
cord-300872-blycbi4u	457	35	,	,	,
cord-300872-blycbi4u	457	36	DLD-1	DLD-1	NNP
cord-300872-blycbi4u	457	37	,	,	,
cord-300872-blycbi4u	457	38	HCT	HCT	NNP
cord-300872-blycbi4u	457	39	116	116	CD
cord-300872-blycbi4u	457	40	,	,	,
cord-300872-blycbi4u	457	41	cervix	cervix	NN
cord-300872-blycbi4u	457	42	carcinoma	carcinoma	NN
cord-300872-blycbi4u	457	43	KB	KB	NNP
cord-300872-blycbi4u	457	44	-	-	HYPH
cord-300872-blycbi4u	457	45	V1	V1	NNP
cord-300872-blycbi4u	457	46	Vbl	Vbl	NNP
cord-300872-blycbi4u	457	47	,	,	,
cord-300872-blycbi4u	457	48	and	and	CC
cord-300872-blycbi4u	457	49	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	457	50	Tobo	tobo	JJ
cord-300872-blycbi4u	457	51	breast	breast	NN
cord-300872-blycbi4u	457	52	carcinoma	carcinoma	NN
cord-300872-blycbi4u	457	53	cell	cell	NN
cord-300872-blycbi4u	457	54	lines	line	NNS
cord-300872-blycbi4u	457	55	,	,	,
cord-300872-blycbi4u	457	56	in	in	IN
cord-300872-blycbi4u	457	57	addition	addition	NN
cord-300872-blycbi4u	457	58	to	to	IN
cord-300872-blycbi4u	457	59	non	non	JJ
cord-300872-blycbi4u	457	60	-	-	JJ
cord-300872-blycbi4u	457	61	malignant	malignant	JJ
cord-300872-blycbi4u	457	62	fibroblasts	fibroblast	NNS
cord-300872-blycbi4u	457	63	.	.	.
cord-300872-blycbi4u	458	1	The	the	DT
cord-300872-blycbi4u	458	2	results	result	NNS
cord-300872-blycbi4u	458	3	revealed	reveal	VBD
cord-300872-blycbi4u	458	4	that	that	IN
cord-300872-blycbi4u	458	5	that	that	IN
cord-300872-blycbi4u	458	6	these	these	DT
cord-300872-blycbi4u	458	7	derivatives	derivative	NNS
cord-300872-blycbi4u	458	8	exhibit	exhibit	VBP
cord-300872-blycbi4u	458	9	remarkable	remarkable	JJ
cord-300872-blycbi4u	458	10	activities	activity	NNS
cord-300872-blycbi4u	458	11	,	,	,
cord-300872-blycbi4u	458	12	with	with	IN
cord-300872-blycbi4u	458	13	IC50	ic50	JJ
cord-300872-blycbi4u	458	14	values	value	NNS
cord-300872-blycbi4u	458	15	in	in	IN
cord-300872-blycbi4u	458	16	nanomolar	nanomolar	NNP
cord-300872-blycbi4u	458	17	concentrations	concentration	NNS
cord-300872-blycbi4u	458	18	,	,	,
cord-300872-blycbi4u	458	19	meaning	mean	VBG
cord-300872-blycbi4u	458	20	these	these	DT
cord-300872-blycbi4u	458	21	results	result	NNS
cord-300872-blycbi4u	458	22	are	be	VBP
cord-300872-blycbi4u	458	23	even	even	RB
cord-300872-blycbi4u	458	24	better	well	JJR
cord-300872-blycbi4u	458	25	than	than	IN
cord-300872-blycbi4u	458	26	the	the	DT
cord-300872-blycbi4u	458	27	activity	activity	NN
cord-300872-blycbi4u	458	28	of	of	IN
cord-300872-blycbi4u	458	29	LY290181	ly290181	NN
cord-300872-blycbi4u	458	30	.	.	.
cord-300872-blycbi4u	459	1	Two	two	CD
cord-300872-blycbi4u	459	2	compounds	compound	NNS
cord-300872-blycbi4u	459	3	designated	designate	VBN
cord-300872-blycbi4u	459	4	with	with	IN
cord-300872-blycbi4u	459	5	R	r	NN
cord-300872-blycbi4u	459	6	=	=	SYM
cord-300872-blycbi4u	459	7	CH3	ch3	NN
cord-300872-blycbi4u	459	8	,	,	,
cord-300872-blycbi4u	459	9	R1	R1	NNP
cord-300872-blycbi4u	459	10	=	=	SYM
cord-300872-blycbi4u	459	11	R3	r3	NN
cord-300872-blycbi4u	459	12	=	=	SYM
cord-300872-blycbi4u	459	13	H	h	NN
cord-300872-blycbi4u	459	14	,	,	,
cord-300872-blycbi4u	459	15	R2	r2	NN
cord-300872-blycbi4u	459	16	=	=	SYM
cord-300872-blycbi4u	459	17	R4	r4	NN
cord-300872-blycbi4u	459	18	=	=	NFP
cord-300872-blycbi4u	460	1	F	F	NNP
cord-300872-blycbi4u	460	2	and	and	CC
cord-300872-blycbi4u	460	3	R	R	NNP
cord-300872-blycbi4u	460	4	=	=	SYM
cord-300872-blycbi4u	460	5	CH3	ch3	NN
cord-300872-blycbi4u	460	6	,	,	,
cord-300872-blycbi4u	460	7	R1	R1	NNP
cord-300872-blycbi4u	460	8	=	=	NN
cord-300872-blycbi4u	461	1	R3	r3	NN
cord-300872-blycbi4u	461	2	=	=	NFP
cord-300872-blycbi4u	462	1	R4	r4	NN
cord-300872-blycbi4u	462	2	=	=	SYM
cord-300872-blycbi4u	462	3	H	H	NNP
cord-300872-blycbi4u	462	4	,	,	,
cord-300872-blycbi4u	462	5	R2	R2	NNP
cord-300872-blycbi4u	463	1	=	=	SYM
cord-300872-blycbi4u	463	2	NO2	NO2	NNP
cord-300872-blycbi4u	463	3	were	be	VBD
cord-300872-blycbi4u	463	4	the	the	DT
cord-300872-blycbi4u	463	5	most	most	RBS
cord-300872-blycbi4u	463	6	active	active	JJ
cord-300872-blycbi4u	463	7	among	among	IN
cord-300872-blycbi4u	463	8	all	all	DT
cord-300872-blycbi4u	463	9	examined	examine	VBN
cord-300872-blycbi4u	463	10	molecules	molecule	NNS
cord-300872-blycbi4u	463	11	.	.	.
cord-300872-blycbi4u	464	1	The	the	DT
cord-300872-blycbi4u	464	2	first	first	JJ
cord-300872-blycbi4u	464	3	one	one	NN
cord-300872-blycbi4u	464	4	had	have	VBD
cord-300872-blycbi4u	464	5	IC50	ic50	JJ
cord-300872-blycbi4u	464	6	values	value	NNS
cord-300872-blycbi4u	464	7	of	of	IN
cord-300872-blycbi4u	464	8	20.1	20.1	CD
cord-300872-blycbi4u	464	9	and	and	CC
cord-300872-blycbi4u	464	10	14	14	CD
cord-300872-blycbi4u	464	11	nM	nm	NN
cord-300872-blycbi4u	464	12	against	against	IN
cord-300872-blycbi4u	464	13	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	464	14	and	and	CC
cord-300872-blycbi4u	464	15	KB	KB	NNP
cord-300872-blycbi4u	464	16	-	-	HYPH
cord-300872-blycbi4u	464	17	V1	V1	NNP
cord-300872-blycbi4u	464	18	Vbl	Vbl	NNP
cord-300872-blycbi4u	464	19	,	,	,
cord-300872-blycbi4u	464	20	respectively	respectively	RB
cord-300872-blycbi4u	464	21	.	.	.
cord-300872-blycbi4u	465	1	On	on	IN
cord-300872-blycbi4u	465	2	the	the	DT
cord-300872-blycbi4u	465	3	other	other	JJ
cord-300872-blycbi4u	465	4	hand	hand	NN
cord-300872-blycbi4u	465	5	,	,	,
cord-300872-blycbi4u	465	6	the	the	DT
cord-300872-blycbi4u	465	7	second	second	JJ
cord-300872-blycbi4u	465	8	compound	compound	NN
cord-300872-blycbi4u	465	9	had	have	VBD
cord-300872-blycbi4u	465	10	an	an	DT
cord-300872-blycbi4u	465	11	IC50	IC50	NNP
cord-300872-blycbi4u	465	12	value	value	NN
cord-300872-blycbi4u	465	13	of	of	IN
cord-300872-blycbi4u	465	14	20	20	CD
cord-300872-blycbi4u	465	15	nM	nm	NN
cord-300872-blycbi4u	465	16	against	against	IN
cord-300872-blycbi4u	465	17	KB	KB	NNP
cord-300872-blycbi4u	465	18	-	-	HYPH
cord-300872-blycbi4u	465	19	V1	V1	NNP
cord-300872-blycbi4u	465	20	Vbl	Vbl	NNP
cord-300872-blycbi4u	465	21	,	,	,
cord-300872-blycbi4u	465	22	which	which	WDT
cord-300872-blycbi4u	465	23	is	be	VBZ
cord-300872-blycbi4u	465	24	even	even	RB
cord-300872-blycbi4u	465	25	better	well	JJR
cord-300872-blycbi4u	465	26	than	than	IN
cord-300872-blycbi4u	465	27	the	the	DT
cord-300872-blycbi4u	465	28	reference	reference	NN
cord-300872-blycbi4u	465	29	.	.	.
cord-300872-blycbi4u	466	1	In	in	IN
cord-300872-blycbi4u	466	2	this	this	DT
cord-300872-blycbi4u	466	3	regard	regard	NN
cord-300872-blycbi4u	466	4	,	,	,
cord-300872-blycbi4u	466	5	it	-PRON-	PRP
cord-300872-blycbi4u	466	6	is	be	VBZ
cord-300872-blycbi4u	466	7	worth	worth	JJ
cord-300872-blycbi4u	466	8	mentioning	mention	VBG
cord-300872-blycbi4u	466	9	that	that	IN
cord-300872-blycbi4u	466	10	the	the	DT
cord-300872-blycbi4u	466	11	mechanism	mechanism	NN
cord-300872-blycbi4u	466	12	of	of	IN
cord-300872-blycbi4u	466	13	action	action	NN
cord-300872-blycbi4u	466	14	of	of	IN
cord-300872-blycbi4u	466	15	these	these	DT
cord-300872-blycbi4u	466	16	compounds	compound	NNS
cord-300872-blycbi4u	466	17	may	may	MD
cord-300872-blycbi4u	466	18	be	be	VB
cord-300872-blycbi4u	466	19	associated	associate	VBN
cord-300872-blycbi4u	466	20	with	with	IN
cord-300872-blycbi4u	466	21	tubulin	tubulin	JJ
cord-300872-blycbi4u	466	22	polymerization	polymerization	NN
cord-300872-blycbi4u	466	23	interference	interference	NN
cord-300872-blycbi4u	466	24	and	and	CC
cord-300872-blycbi4u	466	25	ROS	ROS	NNP
cord-300872-blycbi4u	466	26	formation	formation	NN
cord-300872-blycbi4u	466	27	,	,	,
cord-300872-blycbi4u	466	28	in	in	IN
cord-300872-blycbi4u	466	29	which	which	WDT
cord-300872-blycbi4u	466	30	the	the	DT
cord-300872-blycbi4u	466	31	molecule	molecule	NN
cord-300872-blycbi4u	466	32	-	-	HYPH
cord-300872-blycbi4u	466	33	induced	induce	VBN
cord-300872-blycbi4u	466	34	ROS	ROS	NNP
cord-300872-blycbi4u	466	35	generation	generation	NN
cord-300872-blycbi4u	466	36	could	could	MD
cord-300872-blycbi4u	466	37	be	be	VB
cord-300872-blycbi4u	466	38	responsible	responsible	JJ
cord-300872-blycbi4u	466	39	for	for	IN
cord-300872-blycbi4u	466	40	their	-PRON-	PRP$
cord-300872-blycbi4u	466	41	cytotoxicity	cytotoxicity	NN
cord-300872-blycbi4u	466	42	,	,	,
cord-300872-blycbi4u	466	43	since	since	IN
cord-300872-blycbi4u	466	44	ROS	ROS	NNP
cord-300872-blycbi4u	466	45	overproduction	overproduction	NN
cord-300872-blycbi4u	466	46	may	may	MD
cord-300872-blycbi4u	466	47	induce	induce	VB
cord-300872-blycbi4u	466	48	endoplasmic	endoplasmic	NN
cord-300872-blycbi4u	466	49	reticulum	reticulum	NN
cord-300872-blycbi4u	466	50	stress	stress	NN
cord-300872-blycbi4u	466	51	.	.	.
cord-300872-blycbi4u	467	1	Matrix	matrix	NN
cord-300872-blycbi4u	467	2	metalloproteinases	metalloproteinase	NNS
cord-300872-blycbi4u	467	3	(	(	-LRB-
cord-300872-blycbi4u	467	4	MMPs	MMPs	NNP
cord-300872-blycbi4u	467	5	)	)	-RRB-
cord-300872-blycbi4u	467	6	play	play	VB
cord-300872-blycbi4u	467	7	significant	significant	JJ
cord-300872-blycbi4u	467	8	roles	role	NNS
cord-300872-blycbi4u	467	9	in	in	IN
cord-300872-blycbi4u	467	10	cancer	cancer	NN
cord-300872-blycbi4u	467	11	diseases	disease	NNS
cord-300872-blycbi4u	467	12	,	,	,
cord-300872-blycbi4u	467	13	with	with	IN
cord-300872-blycbi4u	467	14	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	467	15	and	and	CC
cord-300872-blycbi4u	467	16	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	467	17	being	be	VBG
cord-300872-blycbi4u	467	18	important	important	JJ
cord-300872-blycbi4u	467	19	types	type	NNS
cord-300872-blycbi4u	467	20	among	among	IN
cord-300872-blycbi4u	467	21	the	the	DT
cord-300872-blycbi4u	467	22	various	various	JJ
cord-300872-blycbi4u	467	23	MMPs	mmp	NNS
cord-300872-blycbi4u	467	24	.	.	.
cord-300872-blycbi4u	468	1	For	for	IN
cord-300872-blycbi4u	468	2	instance	instance	NN
cord-300872-blycbi4u	468	3	,	,	,
cord-300872-blycbi4u	468	4	they	-PRON-	PRP
cord-300872-blycbi4u	468	5	could	could	MD
cord-300872-blycbi4u	468	6	induce	induce	VB
cord-300872-blycbi4u	468	7	the	the	DT
cord-300872-blycbi4u	468	8	release	release	NN
cord-300872-blycbi4u	468	9	of	of	IN
cord-300872-blycbi4u	468	10	cell	cell	NN
cord-300872-blycbi4u	468	11	membrane	membrane	NN
cord-300872-blycbi4u	468	12	precursors	precursor	NNS
cord-300872-blycbi4u	468	13	of	of	IN
cord-300872-blycbi4u	468	14	growth	growth	NN
cord-300872-blycbi4u	468	15	factors	factor	NNS
cord-300872-blycbi4u	468	16	(	(	-LRB-
cord-300872-blycbi4u	468	17	e.g.	e.g.	RB
cord-300872-blycbi4u	468	18	,	,	,
cord-300872-blycbi4u	468	19	epidermal	epidermal	JJ
cord-300872-blycbi4u	468	20	growth	growth	NN
cord-300872-blycbi4u	468	21	factor	factor	NN
cord-300872-blycbi4u	468	22	receptor	receptor	NN
cord-300872-blycbi4u	468	23	)	)	-RRB-
cord-300872-blycbi4u	468	24	ligands	ligand	NNS
cord-300872-blycbi4u	468	25	,	,	,
cord-300872-blycbi4u	468	26	which	which	WDT
cord-300872-blycbi4u	468	27	promote	promote	VBP
cord-300872-blycbi4u	468	28	tumor	tumor	NN
cord-300872-blycbi4u	468	29	proliferation	proliferation	NN
cord-300872-blycbi4u	468	30	[	[	-LRB-
cord-300872-blycbi4u	468	31	42	42	CD
cord-300872-blycbi4u	468	32	,	,	,
cord-300872-blycbi4u	468	33	43	43	CD
cord-300872-blycbi4u	468	34	]	]	-RRB-
cord-300872-blycbi4u	468	35	.	.	.
cord-300872-blycbi4u	469	1	Along	along	IN
cord-300872-blycbi4u	469	2	this	this	DT
cord-300872-blycbi4u	469	3	line	line	NN
cord-300872-blycbi4u	469	4	,	,	,
cord-300872-blycbi4u	469	5	Chen	Chen	NNP
cord-300872-blycbi4u	469	6	and	and	CC
cord-300872-blycbi4u	469	7	colleagues	colleague	NNS
cord-300872-blycbi4u	469	8	described	describe	VBD
cord-300872-blycbi4u	469	9	the	the	DT
cord-300872-blycbi4u	469	10	synthesis	synthesis	NN
cord-300872-blycbi4u	469	11	of	of	IN
cord-300872-blycbi4u	469	12	two	two	CD
cord-300872-blycbi4u	469	13	series	series	NN
cord-300872-blycbi4u	469	14	of	of	IN
cord-300872-blycbi4u	469	15	8-hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	469	16	,	,	,
cord-300872-blycbi4u	469	17	as	as	IN
cord-300872-blycbi4u	469	18	shown	show	VBN
cord-300872-blycbi4u	469	19	in	in	IN
cord-300872-blycbi4u	469	20	Schemes	Schemes	NNP
cord-300872-blycbi4u	469	21	17	17	CD
cord-300872-blycbi4u	469	22	and	and	CC
cord-300872-blycbi4u	469	23	18	18	CD
cord-300872-blycbi4u	469	24	[	[	-LRB-
cord-300872-blycbi4u	469	25	44	44	CD
cord-300872-blycbi4u	469	26	]	]	-RRB-
cord-300872-blycbi4u	469	27	.	.	.
cord-300872-blycbi4u	470	1	In	in	IN
cord-300872-blycbi4u	470	2	Scheme	Scheme	NNP
cord-300872-blycbi4u	470	3	17	17	CD
cord-300872-blycbi4u	470	4	,	,	,
cord-300872-blycbi4u	470	5	the	the	DT
cord-300872-blycbi4u	470	6	first	first	JJ
cord-300872-blycbi4u	470	7	step	step	NN
cord-300872-blycbi4u	470	8	involved	involve	VBN
cord-300872-blycbi4u	470	9	protecting	protect	VBG
cord-300872-blycbi4u	470	10	the	the	DT
cord-300872-blycbi4u	470	11	amino	amino	NN
cord-300872-blycbi4u	470	12	group	group	NN
cord-300872-blycbi4u	470	13	in	in	IN
cord-300872-blycbi4u	470	14	65	65	CD
cord-300872-blycbi4u	470	15	with	with	IN
cord-300872-blycbi4u	470	16	tert	tert	NNP
cord-300872-blycbi4u	470	17	-	-	HYPH
cord-300872-blycbi4u	470	18	butyloxycarbonyl	butyloxycarbonyl	NNP
cord-300872-blycbi4u	470	19	(	(	-LRB-
cord-300872-blycbi4u	470	20	Boc	Boc	NNP
cord-300872-blycbi4u	470	21	)	)	-RRB-
cord-300872-blycbi4u	470	22	,	,	,
cord-300872-blycbi4u	470	23	then	then	RB
cord-300872-blycbi4u	470	24	the	the	DT
cord-300872-blycbi4u	470	25	free	free	JJ
cord-300872-blycbi4u	470	26	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	470	27	acid	acid	NN
cord-300872-blycbi4u	470	28	group	group	NN
cord-300872-blycbi4u	470	29	in	in	IN
cord-300872-blycbi4u	470	30	66	66	CD
cord-300872-blycbi4u	470	31	reacted	react	VBD
cord-300872-blycbi4u	470	32	with	with	IN
cord-300872-blycbi4u	470	33	the	the	DT
cord-300872-blycbi4u	470	34	amino	amino	NN
cord-300872-blycbi4u	470	35	groups	group	NNS
cord-300872-blycbi4u	470	36	in	in	IN
cord-300872-blycbi4u	470	37	various	various	JJ
cord-300872-blycbi4u	470	38	substrates	substrate	NNS
cord-300872-blycbi4u	470	39	leading	lead	VBG
cord-300872-blycbi4u	470	40	,	,	,
cord-300872-blycbi4u	470	41	to	to	IN
cord-300872-blycbi4u	470	42	the	the	DT
cord-300872-blycbi4u	470	43	formation	formation	NN
cord-300872-blycbi4u	470	44	of	of	IN
cord-300872-blycbi4u	470	45	carboxamide	carboxamide	NN
cord-300872-blycbi4u	470	46	67	67	CD
cord-300872-blycbi4u	470	47	.	.	.
cord-300872-blycbi4u	471	1	Other	other	JJ
cord-300872-blycbi4u	471	2	steps	step	NNS
cord-300872-blycbi4u	471	3	involved	involve	VBD
cord-300872-blycbi4u	471	4	deprotection	deprotection	NN
cord-300872-blycbi4u	471	5	to	to	TO
cord-300872-blycbi4u	471	6	liberate	liberate	VB
cord-300872-blycbi4u	471	7	the	the	DT
cord-300872-blycbi4u	471	8	free	free	JJ
cord-300872-blycbi4u	471	9	primary	primary	JJ
cord-300872-blycbi4u	471	10	amine	amine	NN
cord-300872-blycbi4u	471	11	68	68	CD
cord-300872-blycbi4u	471	12	[	[	-LRB-
cord-300872-blycbi4u	471	13	45	45	CD
cord-300872-blycbi4u	471	14	]	]	-RRB-
cord-300872-blycbi4u	471	15	,	,	,
cord-300872-blycbi4u	471	16	which	which	WDT
cord-300872-blycbi4u	471	17	Matrix	matrix	NN
cord-300872-blycbi4u	471	18	metalloproteinases	metalloproteinase	NNS
cord-300872-blycbi4u	471	19	(	(	-LRB-
cord-300872-blycbi4u	471	20	MMPs	MMPs	NNP
cord-300872-blycbi4u	471	21	)	)	-RRB-
cord-300872-blycbi4u	471	22	play	play	VB
cord-300872-blycbi4u	471	23	significant	significant	JJ
cord-300872-blycbi4u	471	24	roles	role	NNS
cord-300872-blycbi4u	471	25	in	in	IN
cord-300872-blycbi4u	471	26	cancer	cancer	NN
cord-300872-blycbi4u	471	27	diseases	disease	NNS
cord-300872-blycbi4u	471	28	,	,	,
cord-300872-blycbi4u	471	29	with	with	IN
cord-300872-blycbi4u	471	30	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	471	31	and	and	CC
cord-300872-blycbi4u	471	32	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	471	33	being	be	VBG
cord-300872-blycbi4u	471	34	important	important	JJ
cord-300872-blycbi4u	471	35	types	type	NNS
cord-300872-blycbi4u	471	36	among	among	IN
cord-300872-blycbi4u	471	37	the	the	DT
cord-300872-blycbi4u	471	38	various	various	JJ
cord-300872-blycbi4u	471	39	MMPs	mmp	NNS
cord-300872-blycbi4u	471	40	.	.	.
cord-300872-blycbi4u	472	1	For	for	IN
cord-300872-blycbi4u	472	2	instance	instance	NN
cord-300872-blycbi4u	472	3	,	,	,
cord-300872-blycbi4u	472	4	they	-PRON-	PRP
cord-300872-blycbi4u	472	5	could	could	MD
cord-300872-blycbi4u	472	6	induce	induce	VB
cord-300872-blycbi4u	472	7	the	the	DT
cord-300872-blycbi4u	472	8	release	release	NN
cord-300872-blycbi4u	472	9	of	of	IN
cord-300872-blycbi4u	472	10	cell	cell	NN
cord-300872-blycbi4u	472	11	membrane	membrane	NN
cord-300872-blycbi4u	472	12	precursors	precursor	NNS
cord-300872-blycbi4u	472	13	of	of	IN
cord-300872-blycbi4u	472	14	growth	growth	NN
cord-300872-blycbi4u	472	15	factors	factor	NNS
cord-300872-blycbi4u	472	16	(	(	-LRB-
cord-300872-blycbi4u	472	17	e.g.	e.g.	RB
cord-300872-blycbi4u	472	18	,	,	,
cord-300872-blycbi4u	472	19	epidermal	epidermal	JJ
cord-300872-blycbi4u	472	20	growth	growth	NN
cord-300872-blycbi4u	472	21	factor	factor	NN
cord-300872-blycbi4u	472	22	receptor	receptor	NN
cord-300872-blycbi4u	472	23	)	)	-RRB-
cord-300872-blycbi4u	472	24	ligands	ligand	NNS
cord-300872-blycbi4u	472	25	,	,	,
cord-300872-blycbi4u	472	26	which	which	WDT
cord-300872-blycbi4u	472	27	promote	promote	VBP
cord-300872-blycbi4u	472	28	tumor	tumor	NN
cord-300872-blycbi4u	472	29	proliferation	proliferation	NN
cord-300872-blycbi4u	472	30	[	[	-LRB-
cord-300872-blycbi4u	472	31	42	42	CD
cord-300872-blycbi4u	472	32	,	,	,
cord-300872-blycbi4u	472	33	43	43	CD
cord-300872-blycbi4u	472	34	]	]	-RRB-
cord-300872-blycbi4u	472	35	.	.	.
cord-300872-blycbi4u	473	1	Along	along	IN
cord-300872-blycbi4u	473	2	this	this	DT
cord-300872-blycbi4u	473	3	line	line	NN
cord-300872-blycbi4u	473	4	,	,	,
cord-300872-blycbi4u	473	5	Chen	Chen	NNP
cord-300872-blycbi4u	473	6	and	and	CC
cord-300872-blycbi4u	473	7	colleagues	colleague	NNS
cord-300872-blycbi4u	473	8	described	describe	VBD
cord-300872-blycbi4u	473	9	the	the	DT
cord-300872-blycbi4u	473	10	synthesis	synthesis	NN
cord-300872-blycbi4u	473	11	of	of	IN
cord-300872-blycbi4u	473	12	two	two	CD
cord-300872-blycbi4u	473	13	series	series	NN
cord-300872-blycbi4u	473	14	of	of	IN
cord-300872-blycbi4u	473	15	8-hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	473	16	,	,	,
cord-300872-blycbi4u	473	17	as	as	IN
cord-300872-blycbi4u	473	18	shown	show	VBN
cord-300872-blycbi4u	473	19	in	in	IN
cord-300872-blycbi4u	473	20	Schemes	Schemes	NNP
cord-300872-blycbi4u	473	21	17	17	CD
cord-300872-blycbi4u	473	22	and	and	CC
cord-300872-blycbi4u	473	23	18	18	CD
cord-300872-blycbi4u	473	24	[	[	-LRB-
cord-300872-blycbi4u	473	25	44	44	CD
cord-300872-blycbi4u	473	26	]	]	-RRB-
cord-300872-blycbi4u	473	27	.	.	.
cord-300872-blycbi4u	474	1	In	in	IN
cord-300872-blycbi4u	474	2	Scheme	Scheme	NNP
cord-300872-blycbi4u	474	3	17	17	CD
cord-300872-blycbi4u	474	4	,	,	,
cord-300872-blycbi4u	474	5	the	the	DT
cord-300872-blycbi4u	474	6	first	first	JJ
cord-300872-blycbi4u	474	7	step	step	NN
cord-300872-blycbi4u	474	8	involved	involve	VBN
cord-300872-blycbi4u	474	9	protecting	protect	VBG
cord-300872-blycbi4u	474	10	the	the	DT
cord-300872-blycbi4u	474	11	amino	amino	NN
cord-300872-blycbi4u	474	12	group	group	NN
cord-300872-blycbi4u	474	13	in	in	IN
cord-300872-blycbi4u	474	14	65	65	CD
cord-300872-blycbi4u	474	15	with	with	IN
cord-300872-blycbi4u	474	16	tert	tert	NNP
cord-300872-blycbi4u	474	17	-	-	HYPH
cord-300872-blycbi4u	474	18	butyloxycarbonyl	butyloxycarbonyl	NNP
cord-300872-blycbi4u	474	19	(	(	-LRB-
cord-300872-blycbi4u	474	20	Boc	Boc	NNP
cord-300872-blycbi4u	474	21	)	)	-RRB-
cord-300872-blycbi4u	474	22	,	,	,
cord-300872-blycbi4u	474	23	then	then	RB
cord-300872-blycbi4u	474	24	the	the	DT
cord-300872-blycbi4u	474	25	free	free	JJ
cord-300872-blycbi4u	474	26	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	474	27	acid	acid	NN
cord-300872-blycbi4u	474	28	group	group	NN
cord-300872-blycbi4u	474	29	in	in	IN
cord-300872-blycbi4u	474	30	66	66	CD
cord-300872-blycbi4u	474	31	reacted	react	VBD
cord-300872-blycbi4u	474	32	with	with	IN
cord-300872-blycbi4u	474	33	the	the	DT
cord-300872-blycbi4u	474	34	amino	amino	NN
cord-300872-blycbi4u	474	35	groups	group	NNS
cord-300872-blycbi4u	474	36	in	in	IN
cord-300872-blycbi4u	474	37	various	various	JJ
cord-300872-blycbi4u	474	38	substrates	substrate	NNS
cord-300872-blycbi4u	474	39	leading	lead	VBG
cord-300872-blycbi4u	474	40	,	,	,
cord-300872-blycbi4u	474	41	to	to	IN
cord-300872-blycbi4u	474	42	the	the	DT
cord-300872-blycbi4u	474	43	formation	formation	NN
cord-300872-blycbi4u	474	44	of	of	IN
cord-300872-blycbi4u	474	45	carboxamide	carboxamide	NN
cord-300872-blycbi4u	474	46	67	67	CD
cord-300872-blycbi4u	474	47	.	.	.
cord-300872-blycbi4u	475	1	Other	other	JJ
cord-300872-blycbi4u	475	2	steps	step	NNS
cord-300872-blycbi4u	475	3	involved	involve	VBD
cord-300872-blycbi4u	475	4	deprotection	deprotection	NN
cord-300872-blycbi4u	475	5	to	to	TO
cord-300872-blycbi4u	475	6	liberate	liberate	VB
cord-300872-blycbi4u	475	7	the	the	DT
cord-300872-blycbi4u	475	8	free	free	JJ
cord-300872-blycbi4u	475	9	primary	primary	JJ
cord-300872-blycbi4u	475	10	amine	amine	NN
cord-300872-blycbi4u	475	11	68	68	CD
cord-300872-blycbi4u	475	12	[	[	-LRB-
cord-300872-blycbi4u	475	13	45	45	CD
cord-300872-blycbi4u	475	14	]	]	-RRB-
cord-300872-blycbi4u	475	15	,	,	,
cord-300872-blycbi4u	475	16	which	which	WDT
cord-300872-blycbi4u	475	17	reacts	react	VBZ
cord-300872-blycbi4u	475	18	with	with	IN
cord-300872-blycbi4u	475	19	5-chloro-8-hydroxyquinoline-7-carboaldehyde	5-chloro-8-hydroxyquinoline-7-carboaldehyde	CD
cord-300872-blycbi4u	475	20	or	or	CC
cord-300872-blycbi4u	475	21	8-hydroxycarbaldehyde	8-hydroxycarbaldehyde	CD
cord-300872-blycbi4u	475	22	through	through	IN
cord-300872-blycbi4u	475	23	reduction	reduction	NN
cord-300872-blycbi4u	475	24	amination	amination	NN
cord-300872-blycbi4u	475	25	to	to	TO
cord-300872-blycbi4u	475	26	yield	yield	VB
cord-300872-blycbi4u	475	27	target	target	NN
cord-300872-blycbi4u	475	28	product	product	NN
cord-300872-blycbi4u	475	29	69	69	CD
cord-300872-blycbi4u	475	30	.	.	.
cord-300872-blycbi4u	476	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	476	2	,	,	,
cord-300872-blycbi4u	476	3	in	in	IN
cord-300872-blycbi4u	476	4	Scheme	Scheme	NNP
cord-300872-blycbi4u	476	5	18	18	CD
cord-300872-blycbi4u	476	6	,	,	,
cord-300872-blycbi4u	476	7	the	the	DT
cord-300872-blycbi4u	476	8	phenolic	phenolic	JJ
cord-300872-blycbi4u	476	9	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	476	10	group	group	NN
cord-300872-blycbi4u	476	11	in	in	IN
cord-300872-blycbi4u	476	12	70	70	CD
cord-300872-blycbi4u	476	13	was	be	VBD
cord-300872-blycbi4u	476	14	protected	protect	VBN
cord-300872-blycbi4u	476	15	and	and	CC
cord-300872-blycbi4u	476	16	reaction	reaction	NN
cord-300872-blycbi4u	476	17	of	of	IN
cord-300872-blycbi4u	476	18	the	the	DT
cord-300872-blycbi4u	476	19	primary	primary	JJ
cord-300872-blycbi4u	476	20	amino	amino	NN
cord-300872-blycbi4u	476	21	group	group	NN
cord-300872-blycbi4u	476	22	in	in	IN
cord-300872-blycbi4u	476	23	70	70	CD
cord-300872-blycbi4u	476	24	with	with	IN
cord-300872-blycbi4u	476	25	substituted	substituted	JJ
cord-300872-blycbi4u	476	26	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	476	27	acids	acid	NNS
cord-300872-blycbi4u	476	28	afforded	afford	VBD
cord-300872-blycbi4u	476	29	derivative	derivative	JJ
cord-300872-blycbi4u	476	30	71	71	CD
cord-300872-blycbi4u	476	31	.	.	.
cord-300872-blycbi4u	477	1	Finally	finally	RB
cord-300872-blycbi4u	477	2	,	,	,
cord-300872-blycbi4u	477	3	deprotection	deprotection	NN
cord-300872-blycbi4u	477	4	of	of	IN
cord-300872-blycbi4u	477	5	the	the	DT
cord-300872-blycbi4u	477	6	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	477	7	group	group	NN
cord-300872-blycbi4u	477	8	yielded	yield	VBD
cord-300872-blycbi4u	477	9	the	the	DT
cord-300872-blycbi4u	477	10	target	target	NN
cord-300872-blycbi4u	477	11	derivative	derivative	JJ
cord-300872-blycbi4u	477	12	72	72	CD
cord-300872-blycbi4u	477	13	.	.	.
cord-300872-blycbi4u	478	1	Molecules	molecule	NNS
cord-300872-blycbi4u	478	2	2020	2020	CD
cord-300872-blycbi4u	478	3	,	,	,
cord-300872-blycbi4u	478	4	25	25	CD
cord-300872-blycbi4u	478	5	,	,	,
cord-300872-blycbi4u	478	6	x	x	NN
cord-300872-blycbi4u	478	7	FOR	for	IN
cord-300872-blycbi4u	478	8	PEER	PEER	NNP
cord-300872-blycbi4u	478	9	REVIEW	REVIEW	NNP
cord-300872-blycbi4u	478	10	15	15	CD
cord-300872-blycbi4u	478	11	of	of	IN
cord-300872-blycbi4u	478	12	26	26	CD
cord-300872-blycbi4u	478	13	reacts	react	VBZ
cord-300872-blycbi4u	478	14	with	with	IN
cord-300872-blycbi4u	478	15	5-chloro-8-hydroxyquinoline-7-carboaldehyde	5-chloro-8-hydroxyquinoline-7-carboaldehyde	CD
cord-300872-blycbi4u	478	16	or	or	CC
cord-300872-blycbi4u	478	17	8-hydroxycarbaldehyde	8-hydroxycarbaldehyde	CD
cord-300872-blycbi4u	478	18	through	through	IN
cord-300872-blycbi4u	478	19	reduction	reduction	NN
cord-300872-blycbi4u	478	20	amination	amination	NN
cord-300872-blycbi4u	478	21	to	to	TO
cord-300872-blycbi4u	478	22	yield	yield	VB
cord-300872-blycbi4u	478	23	target	target	NN
cord-300872-blycbi4u	478	24	product	product	NN
cord-300872-blycbi4u	478	25	69	69	CD
cord-300872-blycbi4u	478	26	.	.	.
cord-300872-blycbi4u	479	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	479	2	,	,	,
cord-300872-blycbi4u	479	3	in	in	IN
cord-300872-blycbi4u	479	4	Scheme	Scheme	NNP
cord-300872-blycbi4u	479	5	18	18	CD
cord-300872-blycbi4u	479	6	,	,	,
cord-300872-blycbi4u	479	7	the	the	DT
cord-300872-blycbi4u	479	8	phenolic	phenolic	JJ
cord-300872-blycbi4u	479	9	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	479	10	group	group	NN
cord-300872-blycbi4u	479	11	in	in	IN
cord-300872-blycbi4u	479	12	70	70	CD
cord-300872-blycbi4u	479	13	was	be	VBD
cord-300872-blycbi4u	479	14	protected	protect	VBN
cord-300872-blycbi4u	479	15	and	and	CC
cord-300872-blycbi4u	479	16	reaction	reaction	NN
cord-300872-blycbi4u	479	17	of	of	IN
cord-300872-blycbi4u	479	18	the	the	DT
cord-300872-blycbi4u	479	19	primary	primary	JJ
cord-300872-blycbi4u	479	20	amino	amino	NN
cord-300872-blycbi4u	479	21	group	group	NN
cord-300872-blycbi4u	479	22	in	in	IN
cord-300872-blycbi4u	479	23	70	70	CD
cord-300872-blycbi4u	479	24	with	with	IN
cord-300872-blycbi4u	479	25	substituted	substituted	JJ
cord-300872-blycbi4u	479	26	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	479	27	acids	acid	NNS
cord-300872-blycbi4u	479	28	afforded	afford	VBD
cord-300872-blycbi4u	479	29	derivative	derivative	JJ
cord-300872-blycbi4u	479	30	71	71	CD
cord-300872-blycbi4u	479	31	.	.	.
cord-300872-blycbi4u	480	1	Finally	finally	RB
cord-300872-blycbi4u	480	2	,	,	,
cord-300872-blycbi4u	480	3	deprotection	deprotection	NN
cord-300872-blycbi4u	480	4	of	of	IN
cord-300872-blycbi4u	480	5	the	the	DT
cord-300872-blycbi4u	480	6	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	480	7	group	group	NN
cord-300872-blycbi4u	480	8	yielded	yield	VBD
cord-300872-blycbi4u	480	9	the	the	DT
cord-300872-blycbi4u	480	10	target	target	NN
cord-300872-blycbi4u	480	11	derivative	derivative	JJ
cord-300872-blycbi4u	480	12	72	72	CD
cord-300872-blycbi4u	480	13	.	.	.
cord-300872-blycbi4u	481	1	HO	HO	NNP
cord-300872-blycbi4u	482	1	All	all	DT
cord-300872-blycbi4u	482	2	of	of	IN
cord-300872-blycbi4u	482	3	these	these	DT
cord-300872-blycbi4u	482	4	derivatives	derivative	NNS
cord-300872-blycbi4u	482	5	were	be	VBD
cord-300872-blycbi4u	482	6	screened	screen	VBN
cord-300872-blycbi4u	482	7	as	as	IN
cord-300872-blycbi4u	482	8	potential	potential	JJ
cord-300872-blycbi4u	482	9	MMP-2/9	mmp-2/9	NN
cord-300872-blycbi4u	482	10	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	482	11	.	.	.
cord-300872-blycbi4u	483	1	The	the	DT
cord-300872-blycbi4u	483	2	results	result	NNS
cord-300872-blycbi4u	483	3	revealed	reveal	VBD
cord-300872-blycbi4u	483	4	that	that	IN
cord-300872-blycbi4u	483	5	compounds	compound	NNS
cord-300872-blycbi4u	483	6	(	(	-LRB-
cord-300872-blycbi4u	483	7	of	of	IN
cord-300872-blycbi4u	483	8	series	series	NN
cord-300872-blycbi4u	483	9	1	1	CD
cord-300872-blycbi4u	483	10	)	)	-RRB-
cord-300872-blycbi4u	483	11	that	that	WDT
cord-300872-blycbi4u	483	12	have	have	VBP
cord-300872-blycbi4u	483	13	substituents	substituent	NNS
cord-300872-blycbi4u	483	14	at	at	IN
cord-300872-blycbi4u	483	15	C-7	C-7	NNP
cord-300872-blycbi4u	483	16	on	on	IN
cord-300872-blycbi4u	483	17	the	the	DT
cord-300872-blycbi4u	483	18	quinolone	quinolone	NNP
cord-300872-blycbi4u	483	19	moiety	moiety	NNP
cord-300872-blycbi4u	483	20	showed	show	VBD
cord-300872-blycbi4u	483	21	IC50	ic50	JJ
cord-300872-blycbi4u	483	22	values	value	NNS
cord-300872-blycbi4u	483	23	(	(	-LRB-
cord-300872-blycbi4u	483	24	mM	mm	NN
cord-300872-blycbi4u	483	25	)	)	-RRB-
cord-300872-blycbi4u	483	26	in	in	IN
cord-300872-blycbi4u	483	27	the	the	DT
cord-300872-blycbi4u	483	28	range	range	NN
cord-300872-blycbi4u	483	29	of	of	IN
cord-300872-blycbi4u	483	30	0.81	0.81	CD
cord-300872-blycbi4u	483	31	-	-	SYM
cord-300872-blycbi4u	483	32	10	10	CD
cord-300872-blycbi4u	483	33	,	,	,
cord-300872-blycbi4u	483	34	while	while	IN
cord-300872-blycbi4u	483	35	for	for	IN
cord-300872-blycbi4u	483	36	those	those	DT
cord-300872-blycbi4u	483	37	with	with	IN
cord-300872-blycbi4u	483	38	substituents	substituent	NNS
cord-300872-blycbi4u	483	39	at	at	IN
cord-300872-blycbi4u	483	40	C-5	C-5	NNP
cord-300872-blycbi4u	483	41	,	,	,
cord-300872-blycbi4u	483	42	the	the	DT
cord-300872-blycbi4u	483	43	IC50	ic50	JJ
cord-300872-blycbi4u	483	44	values	value	NNS
cord-300872-blycbi4u	483	45	ranged	range	VBD
cord-300872-blycbi4u	483	46	from	from	IN
cord-300872-blycbi4u	483	47	5.7	5.7	CD
cord-300872-blycbi4u	483	48	to	to	IN
cord-300872-blycbi4u	483	49	10	10	CD
cord-300872-blycbi4u	483	50	.	.	.
cord-300872-blycbi4u	484	1	On	on	IN
cord-300872-blycbi4u	484	2	the	the	DT
cord-300872-blycbi4u	484	3	other	other	JJ
cord-300872-blycbi4u	484	4	hand	hand	NN
cord-300872-blycbi4u	484	5	,	,	,
cord-300872-blycbi4u	484	6	derivatives	derivative	NNS
cord-300872-blycbi4u	484	7	belonging	belong	VBG
cord-300872-blycbi4u	484	8	to	to	IN
cord-300872-blycbi4u	484	9	series	series	NN
cord-300872-blycbi4u	484	10	2	2	CD
cord-300872-blycbi4u	484	11	showed	show	VBD
cord-300872-blycbi4u	484	12	IC50	ic50	JJ
cord-300872-blycbi4u	484	13	values	value	NNS
cord-300872-blycbi4u	484	14	in	in	IN
cord-300872-blycbi4u	484	15	the	the	DT
cord-300872-blycbi4u	484	16	range	range	NN
cord-300872-blycbi4u	484	17	of	of	IN
cord-300872-blycbi4u	484	18	6.5	6.5	CD
cord-300872-blycbi4u	484	19	-	-	SYM
cord-300872-blycbi4u	484	20	10	10	CD
cord-300872-blycbi4u	484	21	against	against	IN
cord-300872-blycbi4u	484	22	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	484	23	.	.	.
cord-300872-blycbi4u	485	1	As	as	IN
cord-300872-blycbi4u	485	2	for	for	IN
cord-300872-blycbi4u	485	3	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	485	4	,	,	,
cord-300872-blycbi4u	485	5	using	use	VBG
cord-300872-blycbi4u	485	6	the	the	DT
cord-300872-blycbi4u	485	7	same	same	JJ
cord-300872-blycbi4u	485	8	sequence	sequence	NN
cord-300872-blycbi4u	485	9	,	,	,
cord-300872-blycbi4u	485	10	the	the	DT
cord-300872-blycbi4u	485	11	IC50	ic50	JJ
cord-300872-blycbi4u	485	12	values	value	NNS
cord-300872-blycbi4u	485	13	(	(	-LRB-
cord-300872-blycbi4u	485	14	mM	mm	NN
cord-300872-blycbi4u	485	15	)	)	-RRB-
cord-300872-blycbi4u	485	16	were	be	VBD
cord-300872-blycbi4u	485	17	in	in	IN
cord-300872-blycbi4u	485	18	the	the	DT
cord-300872-blycbi4u	485	19	ranges	range	NNS
cord-300872-blycbi4u	485	20	of	of	IN
cord-300872-blycbi4u	485	21	1.3	1.3	CD
cord-300872-blycbi4u	485	22	-	-	SYM
cord-300872-blycbi4u	485	23	10	10	CD
cord-300872-blycbi4u	485	24	,	,	,
cord-300872-blycbi4u	485	25	5.1	5.1	CD
cord-300872-blycbi4u	485	26	-	-	SYM
cord-300872-blycbi4u	485	27	10	10	CD
cord-300872-blycbi4u	485	28	,	,	,
cord-300872-blycbi4u	485	29	and	and	CC
cord-300872-blycbi4u	485	30	˃10	˃10	NNS
cord-300872-blycbi4u	485	31	.	.	.
cord-300872-blycbi4u	486	1	Some	some	DT
cord-300872-blycbi4u	486	2	selected	select	VBN
cord-300872-blycbi4u	486	3	compounds	compound	NNS
cord-300872-blycbi4u	486	4	(	(	-LRB-
cord-300872-blycbi4u	486	5	those	those	DT
cord-300872-blycbi4u	486	6	with	with	IN
cord-300872-blycbi4u	486	7	substituents	substituent	NNS
cord-300872-blycbi4u	486	8	at	at	IN
cord-300872-blycbi4u	486	9	C-7	C-7	NNP
cord-300872-blycbi4u	486	10	)	)	-RRB-
cord-300872-blycbi4u	486	11	were	be	VBD
cord-300872-blycbi4u	486	12	further	further	RB
cord-300872-blycbi4u	486	13	screened	screen	VBN
cord-300872-blycbi4u	486	14	against	against	IN
cord-300872-blycbi4u	486	15	a	a	DT
cord-300872-blycbi4u	486	16	panel	panel	NN
cord-300872-blycbi4u	486	17	of	of	IN
cord-300872-blycbi4u	486	18	cancer	cancer	NN
cord-300872-blycbi4u	486	19	cell	cell	NN
cord-300872-blycbi4u	486	20	lines	line	NNS
cord-300872-blycbi4u	486	21	(	(	-LRB-
cord-300872-blycbi4u	486	22	HL60	HL60	NNP
cord-300872-blycbi4u	486	23	,	,	,
cord-300872-blycbi4u	486	24	K562	k562	XX
cord-300872-blycbi4u	486	25	,	,	,
cord-300872-blycbi4u	486	26	KG1	KG1	NNP
cord-300872-blycbi4u	486	27	,	,	,
cord-300872-blycbi4u	486	28	A549	A549	NNP
cord-300872-blycbi4u	486	29	,	,	,
cord-300872-blycbi4u	486	30	PC-3	PC-3	NNP
cord-300872-blycbi4u	486	31	,	,	,
cord-300872-blycbi4u	486	32	and	and	CC
cord-300872-blycbi4u	486	33	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	486	34	)	)	-RRB-
cord-300872-blycbi4u	486	35	,	,	,
cord-300872-blycbi4u	486	36	along	along	IN
cord-300872-blycbi4u	486	37	with	with	IN
cord-300872-blycbi4u	486	38	human	human	JJ
cord-300872-blycbi4u	486	39	umbilical	umbilical	JJ
cord-300872-blycbi4u	486	40	vein	vein	NN
cord-300872-blycbi4u	486	41	endothelial	endothelial	JJ
cord-300872-blycbi4u	486	42	cells	cell	NNS
cord-300872-blycbi4u	486	43	.	.	.
cord-300872-blycbi4u	487	1	The	the	DT
cord-300872-blycbi4u	487	2	results	result	NNS
cord-300872-blycbi4u	487	3	indicated	indicate	VBD
cord-300872-blycbi4u	487	4	that	that	IN
cord-300872-blycbi4u	487	5	most	most	JJS
cord-300872-blycbi4u	487	6	of	of	IN
cord-300872-blycbi4u	487	7	the	the	DT
cord-300872-blycbi4u	487	8	tested	test	VBN
cord-300872-blycbi4u	487	9	compounds	compound	NNS
cord-300872-blycbi4u	487	10	exhibited	exhibit	VBD
cord-300872-blycbi4u	487	11	good	good	JJ
cord-300872-blycbi4u	487	12	bioactivity	bioactivity	NN
cord-300872-blycbi4u	487	13	,	,	,
cord-300872-blycbi4u	487	14	with	with	IN
cord-300872-blycbi4u	487	15	IC50	ic50	JJ
cord-300872-blycbi4u	487	16	values	value	NNS
cord-300872-blycbi4u	487	17	in	in	IN
cord-300872-blycbi4u	487	18	the	the	DT
cord-300872-blycbi4u	487	19	range	range	NN
cord-300872-blycbi4u	487	20	of	of	IN
cord-300872-blycbi4u	488	1	0.69	0.69	CD
cord-300872-blycbi4u	488	2	-	-	SYM
cord-300872-blycbi4u	488	3	22	22	CD
cord-300872-blycbi4u	488	4	mM.	mm.	NN
cord-300872-blycbi4u	488	5	Finally	finally	RB
cord-300872-blycbi4u	488	6	,	,	,
cord-300872-blycbi4u	488	7	the	the	DT
cord-300872-blycbi4u	488	8	positive	positive	JJ
cord-300872-blycbi4u	488	9	control	control	NN
cord-300872-blycbi4u	488	10	,	,	,
cord-300872-blycbi4u	488	11	All	all	DT
cord-300872-blycbi4u	488	12	of	of	IN
cord-300872-blycbi4u	488	13	these	these	DT
cord-300872-blycbi4u	488	14	derivatives	derivative	NNS
cord-300872-blycbi4u	488	15	were	be	VBD
cord-300872-blycbi4u	488	16	screened	screen	VBN
cord-300872-blycbi4u	488	17	as	as	IN
cord-300872-blycbi4u	488	18	potential	potential	JJ
cord-300872-blycbi4u	488	19	MMP-2/9	mmp-2/9	NN
cord-300872-blycbi4u	488	20	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	488	21	.	.	.
cord-300872-blycbi4u	489	1	The	the	DT
cord-300872-blycbi4u	489	2	results	result	NNS
cord-300872-blycbi4u	489	3	revealed	reveal	VBD
cord-300872-blycbi4u	489	4	that	that	IN
cord-300872-blycbi4u	489	5	compounds	compound	NNS
cord-300872-blycbi4u	489	6	(	(	-LRB-
cord-300872-blycbi4u	489	7	of	of	IN
cord-300872-blycbi4u	489	8	series	series	NN
cord-300872-blycbi4u	489	9	1	1	CD
cord-300872-blycbi4u	489	10	)	)	-RRB-
cord-300872-blycbi4u	489	11	that	that	WDT
cord-300872-blycbi4u	489	12	have	have	VBP
cord-300872-blycbi4u	489	13	substituents	substituent	NNS
cord-300872-blycbi4u	489	14	at	at	IN
cord-300872-blycbi4u	489	15	C-7	C-7	NNP
cord-300872-blycbi4u	489	16	on	on	IN
cord-300872-blycbi4u	489	17	the	the	DT
cord-300872-blycbi4u	489	18	quinolone	quinolone	NNP
cord-300872-blycbi4u	489	19	moiety	moiety	NNP
cord-300872-blycbi4u	489	20	showed	show	VBD
cord-300872-blycbi4u	489	21	IC50	ic50	JJ
cord-300872-blycbi4u	489	22	values	value	NNS
cord-300872-blycbi4u	489	23	(	(	-LRB-
cord-300872-blycbi4u	489	24	mM	mm	NN
cord-300872-blycbi4u	489	25	)	)	-RRB-
cord-300872-blycbi4u	489	26	in	in	IN
cord-300872-blycbi4u	489	27	the	the	DT
cord-300872-blycbi4u	489	28	range	range	NN
cord-300872-blycbi4u	489	29	of	of	IN
cord-300872-blycbi4u	489	30	0.81	0.81	CD
cord-300872-blycbi4u	489	31	-	-	SYM
cord-300872-blycbi4u	489	32	10	10	CD
cord-300872-blycbi4u	489	33	,	,	,
cord-300872-blycbi4u	489	34	while	while	IN
cord-300872-blycbi4u	489	35	for	for	IN
cord-300872-blycbi4u	489	36	those	those	DT
cord-300872-blycbi4u	489	37	with	with	IN
cord-300872-blycbi4u	489	38	substituents	substituent	NNS
cord-300872-blycbi4u	489	39	at	at	IN
cord-300872-blycbi4u	489	40	C-5	C-5	NNP
cord-300872-blycbi4u	489	41	,	,	,
cord-300872-blycbi4u	489	42	the	the	DT
cord-300872-blycbi4u	489	43	IC50	ic50	JJ
cord-300872-blycbi4u	489	44	values	value	NNS
cord-300872-blycbi4u	489	45	ranged	range	VBD
cord-300872-blycbi4u	489	46	from	from	IN
cord-300872-blycbi4u	489	47	5.7	5.7	CD
cord-300872-blycbi4u	489	48	to	to	IN
cord-300872-blycbi4u	489	49	10	10	CD
cord-300872-blycbi4u	489	50	.	.	.
cord-300872-blycbi4u	490	1	On	on	IN
cord-300872-blycbi4u	490	2	the	the	DT
cord-300872-blycbi4u	490	3	other	other	JJ
cord-300872-blycbi4u	490	4	hand	hand	NN
cord-300872-blycbi4u	490	5	,	,	,
cord-300872-blycbi4u	490	6	derivatives	derivative	NNS
cord-300872-blycbi4u	490	7	belonging	belong	VBG
cord-300872-blycbi4u	490	8	to	to	IN
cord-300872-blycbi4u	490	9	series	series	NN
cord-300872-blycbi4u	490	10	2	2	CD
cord-300872-blycbi4u	490	11	showed	show	VBD
cord-300872-blycbi4u	490	12	IC50	ic50	JJ
cord-300872-blycbi4u	490	13	values	value	NNS
cord-300872-blycbi4u	490	14	in	in	IN
cord-300872-blycbi4u	490	15	the	the	DT
cord-300872-blycbi4u	490	16	range	range	NN
cord-300872-blycbi4u	490	17	of	of	IN
cord-300872-blycbi4u	490	18	6.5	6.5	CD
cord-300872-blycbi4u	490	19	-	-	SYM
cord-300872-blycbi4u	490	20	10	10	CD
cord-300872-blycbi4u	490	21	against	against	IN
cord-300872-blycbi4u	490	22	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	490	23	.	.	.
cord-300872-blycbi4u	491	1	As	as	IN
cord-300872-blycbi4u	491	2	for	for	IN
cord-300872-blycbi4u	491	3	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	491	4	,	,	,
cord-300872-blycbi4u	491	5	using	use	VBG
cord-300872-blycbi4u	491	6	the	the	DT
cord-300872-blycbi4u	491	7	same	same	JJ
cord-300872-blycbi4u	491	8	sequence	sequence	NN
cord-300872-blycbi4u	491	9	,	,	,
cord-300872-blycbi4u	491	10	the	the	DT
cord-300872-blycbi4u	491	11	IC50	ic50	JJ
cord-300872-blycbi4u	491	12	values	value	NNS
cord-300872-blycbi4u	491	13	(	(	-LRB-
cord-300872-blycbi4u	491	14	mM	mm	NN
cord-300872-blycbi4u	491	15	)	)	-RRB-
cord-300872-blycbi4u	491	16	were	be	VBD
cord-300872-blycbi4u	491	17	in	in	IN
cord-300872-blycbi4u	491	18	the	the	DT
cord-300872-blycbi4u	491	19	ranges	range	NNS
cord-300872-blycbi4u	491	20	of	of	IN
cord-300872-blycbi4u	491	21	1.3	1.3	CD
cord-300872-blycbi4u	491	22	-	-	SYM
cord-300872-blycbi4u	491	23	10	10	CD
cord-300872-blycbi4u	491	24	,	,	,
cord-300872-blycbi4u	491	25	5.1	5.1	CD
cord-300872-blycbi4u	491	26	-	-	SYM
cord-300872-blycbi4u	491	27	10	10	CD
cord-300872-blycbi4u	491	28	,	,	,
cord-300872-blycbi4u	491	29	and	and	CC
cord-300872-blycbi4u	491	30	˃10	˃10	NNS
cord-300872-blycbi4u	491	31	.	.	.
cord-300872-blycbi4u	492	1	Some	some	DT
cord-300872-blycbi4u	492	2	selected	select	VBN
cord-300872-blycbi4u	492	3	compounds	compound	NNS
cord-300872-blycbi4u	492	4	(	(	-LRB-
cord-300872-blycbi4u	492	5	those	those	DT
cord-300872-blycbi4u	492	6	with	with	IN
cord-300872-blycbi4u	492	7	substituents	substituent	NNS
cord-300872-blycbi4u	492	8	at	at	IN
cord-300872-blycbi4u	492	9	C-7	C-7	NNP
cord-300872-blycbi4u	492	10	)	)	-RRB-
cord-300872-blycbi4u	492	11	were	be	VBD
cord-300872-blycbi4u	492	12	further	further	RB
cord-300872-blycbi4u	492	13	screened	screen	VBN
cord-300872-blycbi4u	492	14	against	against	IN
cord-300872-blycbi4u	492	15	a	a	DT
cord-300872-blycbi4u	492	16	panel	panel	NN
cord-300872-blycbi4u	492	17	of	of	IN
cord-300872-blycbi4u	492	18	cancer	cancer	NN
cord-300872-blycbi4u	492	19	cell	cell	NN
cord-300872-blycbi4u	492	20	lines	line	NNS
cord-300872-blycbi4u	492	21	(	(	-LRB-
cord-300872-blycbi4u	492	22	HL60	HL60	NNP
cord-300872-blycbi4u	492	23	,	,	,
cord-300872-blycbi4u	492	24	K562	k562	XX
cord-300872-blycbi4u	492	25	,	,	,
cord-300872-blycbi4u	492	26	KG1	KG1	NNP
cord-300872-blycbi4u	492	27	,	,	,
cord-300872-blycbi4u	492	28	A549	A549	NNP
cord-300872-blycbi4u	492	29	,	,	,
cord-300872-blycbi4u	492	30	PC-3	PC-3	NNP
cord-300872-blycbi4u	492	31	,	,	,
cord-300872-blycbi4u	492	32	and	and	CC
cord-300872-blycbi4u	492	33	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	492	34	)	)	-RRB-
cord-300872-blycbi4u	492	35	,	,	,
cord-300872-blycbi4u	492	36	along	along	IN
cord-300872-blycbi4u	492	37	with	with	IN
cord-300872-blycbi4u	492	38	human	human	JJ
cord-300872-blycbi4u	492	39	umbilical	umbilical	JJ
cord-300872-blycbi4u	492	40	vein	vein	NN
cord-300872-blycbi4u	492	41	endothelial	endothelial	JJ
cord-300872-blycbi4u	492	42	cells	cell	NNS
cord-300872-blycbi4u	492	43	.	.	.
cord-300872-blycbi4u	493	1	The	the	DT
cord-300872-blycbi4u	493	2	results	result	NNS
cord-300872-blycbi4u	493	3	indicated	indicate	VBD
cord-300872-blycbi4u	493	4	that	that	IN
cord-300872-blycbi4u	493	5	most	most	JJS
cord-300872-blycbi4u	493	6	of	of	IN
cord-300872-blycbi4u	493	7	the	the	DT
cord-300872-blycbi4u	493	8	tested	test	VBN
cord-300872-blycbi4u	493	9	compounds	compound	NNS
cord-300872-blycbi4u	493	10	exhibited	exhibit	VBD
cord-300872-blycbi4u	493	11	good	good	JJ
cord-300872-blycbi4u	493	12	bioactivity	bioactivity	NN
cord-300872-blycbi4u	493	13	,	,	,
cord-300872-blycbi4u	493	14	with	with	IN
cord-300872-blycbi4u	493	15	IC50	ic50	JJ
cord-300872-blycbi4u	493	16	values	value	NNS
cord-300872-blycbi4u	493	17	in	in	IN
cord-300872-blycbi4u	493	18	the	the	DT
cord-300872-blycbi4u	493	19	range	range	NN
cord-300872-blycbi4u	493	20	of	of	IN
cord-300872-blycbi4u	494	1	0.69	0.69	CD
cord-300872-blycbi4u	494	2	-	-	SYM
cord-300872-blycbi4u	494	3	22	22	CD
cord-300872-blycbi4u	494	4	mM.	mm.	NN
cord-300872-blycbi4u	494	5	Finally	finally	RB
cord-300872-blycbi4u	494	6	,	,	,
cord-300872-blycbi4u	494	7	the	the	DT
cord-300872-blycbi4u	494	8	positive	positive	JJ
cord-300872-blycbi4u	494	9	control	control	NN
cord-300872-blycbi4u	494	10	,	,	,
cord-300872-blycbi4u	494	11	All	all	DT
cord-300872-blycbi4u	494	12	of	of	IN
cord-300872-blycbi4u	494	13	these	these	DT
cord-300872-blycbi4u	494	14	derivatives	derivative	NNS
cord-300872-blycbi4u	494	15	were	be	VBD
cord-300872-blycbi4u	494	16	screened	screen	VBN
cord-300872-blycbi4u	494	17	as	as	IN
cord-300872-blycbi4u	494	18	potential	potential	JJ
cord-300872-blycbi4u	494	19	MMP-2/9	mmp-2/9	NN
cord-300872-blycbi4u	494	20	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	494	21	.	.	.
cord-300872-blycbi4u	495	1	The	the	DT
cord-300872-blycbi4u	495	2	results	result	NNS
cord-300872-blycbi4u	495	3	revealed	reveal	VBD
cord-300872-blycbi4u	495	4	that	that	IN
cord-300872-blycbi4u	495	5	compounds	compound	NNS
cord-300872-blycbi4u	495	6	(	(	-LRB-
cord-300872-blycbi4u	495	7	of	of	IN
cord-300872-blycbi4u	495	8	series	series	NN
cord-300872-blycbi4u	495	9	1	1	CD
cord-300872-blycbi4u	495	10	)	)	-RRB-
cord-300872-blycbi4u	495	11	that	that	WDT
cord-300872-blycbi4u	495	12	have	have	VBP
cord-300872-blycbi4u	495	13	substituents	substituent	NNS
cord-300872-blycbi4u	495	14	at	at	IN
cord-300872-blycbi4u	495	15	C-7	C-7	NNP
cord-300872-blycbi4u	495	16	on	on	IN
cord-300872-blycbi4u	495	17	the	the	DT
cord-300872-blycbi4u	495	18	quinolone	quinolone	NNP
cord-300872-blycbi4u	495	19	moiety	moiety	NNP
cord-300872-blycbi4u	495	20	showed	show	VBD
cord-300872-blycbi4u	495	21	IC	IC	NNP
cord-300872-blycbi4u	495	22	50	50	CD
cord-300872-blycbi4u	495	23	values	value	NNS
cord-300872-blycbi4u	495	24	(	(	-LRB-
cord-300872-blycbi4u	495	25	mM	mm	NN
cord-300872-blycbi4u	495	26	)	)	-RRB-
cord-300872-blycbi4u	495	27	in	in	IN
cord-300872-blycbi4u	495	28	the	the	DT
cord-300872-blycbi4u	495	29	range	range	NN
cord-300872-blycbi4u	495	30	of	of	IN
cord-300872-blycbi4u	495	31	0.81	0.81	CD
cord-300872-blycbi4u	495	32	-	-	SYM
cord-300872-blycbi4u	495	33	10	10	CD
cord-300872-blycbi4u	495	34	,	,	,
cord-300872-blycbi4u	495	35	while	while	IN
cord-300872-blycbi4u	495	36	for	for	IN
cord-300872-blycbi4u	495	37	those	those	DT
cord-300872-blycbi4u	495	38	with	with	IN
cord-300872-blycbi4u	495	39	substituents	substituent	NNS
cord-300872-blycbi4u	495	40	at	at	IN
cord-300872-blycbi4u	495	41	C-5	C-5	NNP
cord-300872-blycbi4u	495	42	,	,	,
cord-300872-blycbi4u	495	43	the	the	DT
cord-300872-blycbi4u	495	44	IC	IC	NNP
cord-300872-blycbi4u	495	45	50	50	CD
cord-300872-blycbi4u	495	46	values	value	NNS
cord-300872-blycbi4u	495	47	ranged	range	VBD
cord-300872-blycbi4u	495	48	from	from	IN
cord-300872-blycbi4u	495	49	5.7	5.7	CD
cord-300872-blycbi4u	495	50	to	to	IN
cord-300872-blycbi4u	495	51	10	10	CD
cord-300872-blycbi4u	495	52	.	.	.
cord-300872-blycbi4u	496	1	On	on	IN
cord-300872-blycbi4u	496	2	the	the	DT
cord-300872-blycbi4u	496	3	other	other	JJ
cord-300872-blycbi4u	496	4	hand	hand	NN
cord-300872-blycbi4u	496	5	,	,	,
cord-300872-blycbi4u	496	6	derivatives	derivative	NNS
cord-300872-blycbi4u	496	7	belonging	belong	VBG
cord-300872-blycbi4u	496	8	to	to	IN
cord-300872-blycbi4u	496	9	series	series	NN
cord-300872-blycbi4u	496	10	2	2	CD
cord-300872-blycbi4u	496	11	showed	show	VBD
cord-300872-blycbi4u	496	12	IC	IC	NNP
cord-300872-blycbi4u	496	13	50	50	CD
cord-300872-blycbi4u	496	14	values	value	NNS
cord-300872-blycbi4u	496	15	in	in	IN
cord-300872-blycbi4u	496	16	the	the	DT
cord-300872-blycbi4u	496	17	range	range	NN
cord-300872-blycbi4u	496	18	of	of	IN
cord-300872-blycbi4u	496	19	6.5	6.5	CD
cord-300872-blycbi4u	496	20	-	-	SYM
cord-300872-blycbi4u	496	21	10	10	CD
cord-300872-blycbi4u	496	22	against	against	IN
cord-300872-blycbi4u	496	23	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	496	24	.	.	.
cord-300872-blycbi4u	497	1	As	as	IN
cord-300872-blycbi4u	497	2	for	for	IN
cord-300872-blycbi4u	497	3	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	497	4	,	,	,
cord-300872-blycbi4u	497	5	using	use	VBG
cord-300872-blycbi4u	497	6	the	the	DT
cord-300872-blycbi4u	497	7	same	same	JJ
cord-300872-blycbi4u	497	8	sequence	sequence	NN
cord-300872-blycbi4u	497	9	,	,	,
cord-300872-blycbi4u	497	10	the	the	DT
cord-300872-blycbi4u	497	11	IC	IC	NNP
cord-300872-blycbi4u	497	12	50	50	CD
cord-300872-blycbi4u	497	13	values	value	NNS
cord-300872-blycbi4u	497	14	(	(	-LRB-
cord-300872-blycbi4u	497	15	mM	mm	NN
cord-300872-blycbi4u	497	16	)	)	-RRB-
cord-300872-blycbi4u	497	17	were	be	VBD
cord-300872-blycbi4u	497	18	in	in	IN
cord-300872-blycbi4u	497	19	the	the	DT
cord-300872-blycbi4u	497	20	ranges	range	NNS
cord-300872-blycbi4u	497	21	of	of	IN
cord-300872-blycbi4u	497	22	1.3	1.3	CD
cord-300872-blycbi4u	497	23	-	-	SYM
cord-300872-blycbi4u	497	24	10	10	CD
cord-300872-blycbi4u	497	25	,	,	,
cord-300872-blycbi4u	497	26	5.1	5.1	CD
cord-300872-blycbi4u	497	27	-	-	SYM
cord-300872-blycbi4u	497	28	10	10	CD
cord-300872-blycbi4u	497	29	,	,	,
cord-300872-blycbi4u	497	30	and	and	CC
cord-300872-blycbi4u	497	31	>	>	XX
cord-300872-blycbi4u	497	32	10	10	CD
cord-300872-blycbi4u	497	33	.	.	.
cord-300872-blycbi4u	498	1	Some	some	DT
cord-300872-blycbi4u	498	2	selected	select	VBN
cord-300872-blycbi4u	498	3	compounds	compound	NNS
cord-300872-blycbi4u	498	4	(	(	-LRB-
cord-300872-blycbi4u	498	5	those	those	DT
cord-300872-blycbi4u	498	6	with	with	IN
cord-300872-blycbi4u	498	7	substituents	substituent	NNS
cord-300872-blycbi4u	498	8	at	at	IN
cord-300872-blycbi4u	498	9	C-7	C-7	NNP
cord-300872-blycbi4u	498	10	)	)	-RRB-
cord-300872-blycbi4u	498	11	were	be	VBD
cord-300872-blycbi4u	498	12	further	further	RB
cord-300872-blycbi4u	498	13	screened	screen	VBN
cord-300872-blycbi4u	498	14	against	against	IN
cord-300872-blycbi4u	498	15	a	a	DT
cord-300872-blycbi4u	498	16	panel	panel	NN
cord-300872-blycbi4u	498	17	of	of	IN
cord-300872-blycbi4u	498	18	cancer	cancer	NN
cord-300872-blycbi4u	498	19	cell	cell	NN
cord-300872-blycbi4u	498	20	lines	line	NNS
cord-300872-blycbi4u	498	21	(	(	-LRB-
cord-300872-blycbi4u	498	22	HL60	HL60	NNP
cord-300872-blycbi4u	498	23	,	,	,
cord-300872-blycbi4u	498	24	K562	k562	XX
cord-300872-blycbi4u	498	25	,	,	,
cord-300872-blycbi4u	498	26	KG1	KG1	NNP
cord-300872-blycbi4u	498	27	,	,	,
cord-300872-blycbi4u	498	28	A549	A549	NNP
cord-300872-blycbi4u	498	29	,	,	,
cord-300872-blycbi4u	498	30	PC-3	PC-3	NNP
cord-300872-blycbi4u	498	31	,	,	,
cord-300872-blycbi4u	498	32	and	and	CC
cord-300872-blycbi4u	498	33	MCF-7	MCF-7	NNP
cord-300872-blycbi4u	498	34	)	)	-RRB-
cord-300872-blycbi4u	498	35	,	,	,
cord-300872-blycbi4u	498	36	along	along	IN
cord-300872-blycbi4u	498	37	with	with	IN
cord-300872-blycbi4u	498	38	human	human	JJ
cord-300872-blycbi4u	498	39	umbilical	umbilical	JJ
cord-300872-blycbi4u	498	40	vein	vein	NN
cord-300872-blycbi4u	498	41	endothelial	endothelial	JJ
cord-300872-blycbi4u	498	42	cells	cell	NNS
cord-300872-blycbi4u	498	43	.	.	.
cord-300872-blycbi4u	499	1	The	the	DT
cord-300872-blycbi4u	499	2	results	result	NNS
cord-300872-blycbi4u	499	3	indicated	indicate	VBD
cord-300872-blycbi4u	499	4	that	that	IN
cord-300872-blycbi4u	499	5	most	most	JJS
cord-300872-blycbi4u	499	6	of	of	IN
cord-300872-blycbi4u	499	7	the	the	DT
cord-300872-blycbi4u	499	8	tested	test	VBN
cord-300872-blycbi4u	499	9	compounds	compound	NNS
cord-300872-blycbi4u	499	10	exhibited	exhibit	VBD
cord-300872-blycbi4u	499	11	good	good	JJ
cord-300872-blycbi4u	499	12	bioactivity	bioactivity	NN
cord-300872-blycbi4u	499	13	,	,	,
cord-300872-blycbi4u	499	14	with	with	IN
cord-300872-blycbi4u	499	15	IC	IC	NNP
cord-300872-blycbi4u	499	16	50	50	CD
cord-300872-blycbi4u	499	17	values	value	NNS
cord-300872-blycbi4u	499	18	in	in	IN
cord-300872-blycbi4u	499	19	the	the	DT
cord-300872-blycbi4u	499	20	range	range	NN
cord-300872-blycbi4u	499	21	of	of	IN
cord-300872-blycbi4u	500	1	0.69	0.69	CD
cord-300872-blycbi4u	500	2	-	-	SYM
cord-300872-blycbi4u	500	3	22	22	CD
cord-300872-blycbi4u	500	4	mM.	mm.	NN
cord-300872-blycbi4u	500	5	Finally	finally	RB
cord-300872-blycbi4u	500	6	,	,	,
cord-300872-blycbi4u	500	7	the	the	DT
cord-300872-blycbi4u	500	8	positive	positive	JJ
cord-300872-blycbi4u	500	9	control	control	NN
cord-300872-blycbi4u	500	10	,	,	,
cord-300872-blycbi4u	500	11	the	the	DT
cord-300872-blycbi4u	500	12	hydroxamate	hydroxamate	NN
cord-300872-blycbi4u	500	13	-	-	HYPH
cord-300872-blycbi4u	500	14	based	base	VBN
cord-300872-blycbi4u	500	15	MMP	MMP	NNP
cord-300872-blycbi4u	500	16	inhibitor	inhibitor	NN
cord-300872-blycbi4u	500	17	NNGH	NNGH	NNP
cord-300872-blycbi4u	500	18	[	[	-LRB-
cord-300872-blycbi4u	500	19	46	46	CD
cord-300872-blycbi4u	500	20	]	]	-RRB-
cord-300872-blycbi4u	500	21	,	,	,
cord-300872-blycbi4u	500	22	showed	show	VBD
cord-300872-blycbi4u	500	23	IC	IC	NNP
cord-300872-blycbi4u	500	24	50	50	CD
cord-300872-blycbi4u	500	25	values	value	NNS
cord-300872-blycbi4u	500	26	of	of	IN
cord-300872-blycbi4u	500	27	29	29	CD
cord-300872-blycbi4u	500	28	-	-	SYM
cord-300872-blycbi4u	500	29	187	187	CD
cord-300872-blycbi4u	500	30	mM	mm	CD
cord-300872-blycbi4u	500	31	for	for	IN
cord-300872-blycbi4u	500	32	antiproliferation	antiproliferation	NN
cord-300872-blycbi4u	500	33	activities	activity	NNS
cord-300872-blycbi4u	500	34	against	against	IN
cord-300872-blycbi4u	500	35	various	various	JJ
cord-300872-blycbi4u	500	36	cancer	cancer	NN
cord-300872-blycbi4u	500	37	cell	cell	NN
cord-300872-blycbi4u	500	38	lines	line	NNS
cord-300872-blycbi4u	500	39	,	,	,
cord-300872-blycbi4u	500	40	and	and	CC
cord-300872-blycbi4u	500	41	against	against	IN
cord-300872-blycbi4u	500	42	MMP-2	MMP-2	NNP
cord-300872-blycbi4u	500	43	and	and	CC
cord-300872-blycbi4u	500	44	MMP-9	MMP-9	NNP
cord-300872-blycbi4u	500	45	showed	show	VBD
cord-300872-blycbi4u	500	46	values	value	NNS
cord-300872-blycbi4u	500	47	of	of	IN
cord-300872-blycbi4u	500	48	0.0091	0.0091	CD
cord-300872-blycbi4u	500	49	and	and	CC
cord-300872-blycbi4u	500	50	0.0088	0.0088	CD
cord-300872-blycbi4u	500	51	mM	mm	CD
cord-300872-blycbi4u	500	52	,	,	,
cord-300872-blycbi4u	500	53	respectively	respectively	RB
cord-300872-blycbi4u	500	54	.	.	.
cord-300872-blycbi4u	501	1	Ökten	Ökten	NNP
cord-300872-blycbi4u	501	2	and	and	CC
cord-300872-blycbi4u	501	3	coworkers	coworker	NNS
cord-300872-blycbi4u	501	4	described	describe	VBD
cord-300872-blycbi4u	501	5	the	the	DT
cord-300872-blycbi4u	501	6	synthesis	synthesis	NN
cord-300872-blycbi4u	501	7	of	of	IN
cord-300872-blycbi4u	501	8	5,7-dibromo-8-hydroxyquinoline	5,7-dibromo-8-hydroxyquinoline	CD
cord-300872-blycbi4u	501	9	[	[	-LRB-
cord-300872-blycbi4u	501	10	47	47	CD
cord-300872-blycbi4u	501	11	]	]	-RRB-
cord-300872-blycbi4u	501	12	in	in	IN
cord-300872-blycbi4u	501	13	excellent	excellent	JJ
cord-300872-blycbi4u	501	14	yield	yield	NN
cord-300872-blycbi4u	501	15	via	via	IN
cord-300872-blycbi4u	501	16	reaction	reaction	NN
cord-300872-blycbi4u	501	17	of	of	IN
cord-300872-blycbi4u	501	18	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	501	19	with	with	IN
cord-300872-blycbi4u	501	20	two	two	CD
cord-300872-blycbi4u	501	21	equivalents	equivalent	NNS
cord-300872-blycbi4u	501	22	of	of	IN
cord-300872-blycbi4u	501	23	bromine	bromine	NN
cord-300872-blycbi4u	501	24	in	in	IN
cord-300872-blycbi4u	501	25	chloroform	chloroform	NN
cord-300872-blycbi4u	501	26	.	.	.
cord-300872-blycbi4u	502	1	The	the	DT
cord-300872-blycbi4u	502	2	target	target	NN
cord-300872-blycbi4u	502	3	molecule	molecule	NN
cord-300872-blycbi4u	502	4	exhibited	exhibit	VBD
cord-300872-blycbi4u	502	5	IC	IC	NNP
cord-300872-blycbi4u	502	6	50	50	CD
cord-300872-blycbi4u	502	7	values	value	NNS
cord-300872-blycbi4u	502	8	(	(	-LRB-
cord-300872-blycbi4u	502	9	mg	mg	NN
cord-300872-blycbi4u	502	10	/	/	SYM
cord-300872-blycbi4u	502	11	mL	mL	NNP
cord-300872-blycbi4u	502	12	)	)	-RRB-
cord-300872-blycbi4u	502	13	of	of	IN
cord-300872-blycbi4u	502	14	5.8	5.8	CD
cord-300872-blycbi4u	502	15	,	,	,
cord-300872-blycbi4u	502	16	17.6	17.6	CD
cord-300872-blycbi4u	502	17	,	,	,
cord-300872-blycbi4u	502	18	18.7	18.7	CD
cord-300872-blycbi4u	502	19	,	,	,
cord-300872-blycbi4u	502	20	5.4	5.4	CD
cord-300872-blycbi4u	502	21	,	,	,
cord-300872-blycbi4u	502	22	16.5	16.5	CD
cord-300872-blycbi4u	502	23	,	,	,
cord-300872-blycbi4u	502	24	and	and	CC
cord-300872-blycbi4u	502	25	>	>	XX
cord-300872-blycbi4u	502	26	1000	1000	CD
cord-300872-blycbi4u	502	27	against	against	IN
cord-300872-blycbi4u	502	28	A549	A549	NNP
cord-300872-blycbi4u	502	29	,	,	,
cord-300872-blycbi4u	502	30	FL	FL	NNP
cord-300872-blycbi4u	502	31	,	,	,
cord-300872-blycbi4u	502	32	HeLa	HeLa	NNP
cord-300872-blycbi4u	502	33	,	,	,
cord-300872-blycbi4u	502	34	HT29	HT29	NNP
cord-300872-blycbi4u	502	35	,	,	,
cord-300872-blycbi4u	502	36	MCF7	MCF7	NNP
cord-300872-blycbi4u	502	37	,	,	,
cord-300872-blycbi4u	502	38	and	and	CC
cord-300872-blycbi4u	502	39	Hep3B	Hep3B	NNS
cord-300872-blycbi4u	502	40	,	,	,
cord-300872-blycbi4u	502	41	respectively	respectively	RB
cord-300872-blycbi4u	502	42	.	.	.
cord-300872-blycbi4u	503	1	From	from	IN
cord-300872-blycbi4u	503	2	all	all	DT
cord-300872-blycbi4u	503	3	of	of	IN
cord-300872-blycbi4u	503	4	these	these	DT
cord-300872-blycbi4u	503	5	studies	study	NNS
cord-300872-blycbi4u	503	6	,	,	,
cord-300872-blycbi4u	503	7	one	one	PRP
cord-300872-blycbi4u	503	8	can	can	MD
cord-300872-blycbi4u	503	9	see	see	VB
cord-300872-blycbi4u	503	10	the	the	DT
cord-300872-blycbi4u	503	11	importance	importance	NN
cord-300872-blycbi4u	503	12	of	of	IN
cord-300872-blycbi4u	503	13	the	the	DT
cord-300872-blycbi4u	503	14	8-HQ	8-hq	CD
cord-300872-blycbi4u	503	15	moiety	moiety	NN
cord-300872-blycbi4u	503	16	in	in	IN
cord-300872-blycbi4u	503	17	potential	potential	JJ
cord-300872-blycbi4u	503	18	anticancer	anticancer	JJ
cord-300872-blycbi4u	503	19	drugs	drug	NNS
cord-300872-blycbi4u	503	20	.	.	.
cord-300872-blycbi4u	504	1	In	in	IN
cord-300872-blycbi4u	504	2	addition	addition	NN
cord-300872-blycbi4u	504	3	,	,	,
cord-300872-blycbi4u	504	4	some	some	DT
cord-300872-blycbi4u	504	5	of	of	IN
cord-300872-blycbi4u	504	6	the	the	DT
cord-300872-blycbi4u	504	7	prepared	prepared	JJ
cord-300872-blycbi4u	504	8	compounds	compound	NNS
cord-300872-blycbi4u	504	9	could	could	MD
cord-300872-blycbi4u	504	10	be	be	VB
cord-300872-blycbi4u	504	11	leads	lead	NNS
cord-300872-blycbi4u	504	12	towards	towards	IN
cord-300872-blycbi4u	504	13	the	the	DT
cord-300872-blycbi4u	504	14	development	development	NN
cord-300872-blycbi4u	504	15	of	of	IN
cord-300872-blycbi4u	504	16	potent	potent	JJ
cord-300872-blycbi4u	504	17	and	and	CC
cord-300872-blycbi4u	504	18	safe	safe	JJ
cord-300872-blycbi4u	504	19	drugs	drug	NNS
cord-300872-blycbi4u	504	20	.	.	.
cord-300872-blycbi4u	505	1	However	however	RB
cord-300872-blycbi4u	505	2	,	,	,
cord-300872-blycbi4u	505	3	more	more	JJR
cord-300872-blycbi4u	505	4	work	work	NN
cord-300872-blycbi4u	505	5	is	be	VBZ
cord-300872-blycbi4u	505	6	required	require	VBN
cord-300872-blycbi4u	505	7	in	in	IN
cord-300872-blycbi4u	505	8	this	this	DT
cord-300872-blycbi4u	505	9	category	category	NN
cord-300872-blycbi4u	505	10	,	,	,
cord-300872-blycbi4u	505	11	which	which	WDT
cord-300872-blycbi4u	505	12	could	could	MD
cord-300872-blycbi4u	505	13	involve	involve	VB
cord-300872-blycbi4u	505	14	the	the	DT
cord-300872-blycbi4u	505	15	use	use	NN
cord-300872-blycbi4u	505	16	of	of	IN
cord-300872-blycbi4u	505	17	animals	animal	NNS
cord-300872-blycbi4u	505	18	and	and	CC
cord-300872-blycbi4u	505	19	possibly	possibly	RB
cord-300872-blycbi4u	505	20	human	human	JJ
cord-300872-blycbi4u	505	21	subjects	subject	NNS
cord-300872-blycbi4u	505	22	to	to	TO
cord-300872-blycbi4u	505	23	evaluate	evaluate	VB
cord-300872-blycbi4u	505	24	the	the	DT
cord-300872-blycbi4u	505	25	efficacy	efficacy	NN
cord-300872-blycbi4u	505	26	and	and	CC
cord-300872-blycbi4u	505	27	safety	safety	NN
cord-300872-blycbi4u	505	28	profiles	profile	NNS
cord-300872-blycbi4u	505	29	of	of	IN
cord-300872-blycbi4u	505	30	the	the	DT
cord-300872-blycbi4u	505	31	prepared	prepared	JJ
cord-300872-blycbi4u	505	32	compounds	compound	NNS
cord-300872-blycbi4u	505	33	.	.	.
cord-300872-blycbi4u	506	1	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	506	2	's	's	POS
cord-300872-blycbi4u	506	3	disease	disease	NN
cord-300872-blycbi4u	506	4	(	(	-LRB-
cord-300872-blycbi4u	506	5	AD	ad	NN
cord-300872-blycbi4u	506	6	)	)	-RRB-
cord-300872-blycbi4u	506	7	,	,	,
cord-300872-blycbi4u	506	8	characterized	characterize	VBN
cord-300872-blycbi4u	506	9	by	by	IN
cord-300872-blycbi4u	506	10	a	a	DT
cord-300872-blycbi4u	506	11	loss	loss	NN
cord-300872-blycbi4u	506	12	of	of	IN
cord-300872-blycbi4u	506	13	cognitive	cognitive	JJ
cord-300872-blycbi4u	506	14	ability	ability	NN
cord-300872-blycbi4u	506	15	and	and	CC
cord-300872-blycbi4u	506	16	severe	severe	JJ
cord-300872-blycbi4u	506	17	behavioral	behavioral	JJ
cord-300872-blycbi4u	506	18	irregularities	irregularity	NNS
cord-300872-blycbi4u	506	19	,	,	,
cord-300872-blycbi4u	506	20	is	be	VBZ
cord-300872-blycbi4u	506	21	a	a	DT
cord-300872-blycbi4u	506	22	chronic	chronic	JJ
cord-300872-blycbi4u	506	23	neurodegenerative	neurodegenerative	JJ
cord-300872-blycbi4u	506	24	disorder	disorder	NN
cord-300872-blycbi4u	506	25	.	.	.
cord-300872-blycbi4u	507	1	It	-PRON-	PRP
cord-300872-blycbi4u	507	2	is	be	VBZ
cord-300872-blycbi4u	507	3	most	most	RBS
cord-300872-blycbi4u	507	4	common	common	JJ
cord-300872-blycbi4u	507	5	among	among	IN
cord-300872-blycbi4u	507	6	the	the	DT
cord-300872-blycbi4u	507	7	elderly	elderly	JJ
cord-300872-blycbi4u	507	8	,	,	,
cord-300872-blycbi4u	507	9	and	and	CC
cord-300872-blycbi4u	507	10	can	can	MD
cord-300872-blycbi4u	507	11	be	be	VB
cord-300872-blycbi4u	507	12	described	describe	VBN
cord-300872-blycbi4u	507	13	as	as	IN
cord-300872-blycbi4u	507	14	an	an	DT
cord-300872-blycbi4u	507	15	irreversible	irreversible	JJ
cord-300872-blycbi4u	507	16	brain	brain	NN
cord-300872-blycbi4u	507	17	disorder	disorder	NN
cord-300872-blycbi4u	507	18	that	that	WDT
cord-300872-blycbi4u	507	19	breaks	break	VBZ
cord-300872-blycbi4u	507	20	down	down	RP
cord-300872-blycbi4u	507	21	memory	memory	NN
cord-300872-blycbi4u	507	22	and	and	CC
cord-300872-blycbi4u	507	23	reduces	reduce	VBZ
cord-300872-blycbi4u	507	24	the	the	DT
cord-300872-blycbi4u	507	25	ability	ability	NN
cord-300872-blycbi4u	507	26	of	of	IN
cord-300872-blycbi4u	507	27	a	a	DT
cord-300872-blycbi4u	507	28	patient	patient	NN
cord-300872-blycbi4u	507	29	to	to	TO
cord-300872-blycbi4u	507	30	carry	carry	VB
cord-300872-blycbi4u	507	31	out	out	RP
cord-300872-blycbi4u	507	32	simple	simple	JJ
cord-300872-blycbi4u	507	33	mental	mental	JJ
cord-300872-blycbi4u	507	34	and	and	CC
cord-300872-blycbi4u	507	35	cognitive	cognitive	JJ
cord-300872-blycbi4u	507	36	functions	function	NNS
cord-300872-blycbi4u	507	37	,	,	,
cord-300872-blycbi4u	507	38	such	such	JJ
cord-300872-blycbi4u	507	39	as	as	IN
cord-300872-blycbi4u	507	40	comprehension	comprehension	NN
cord-300872-blycbi4u	507	41	,	,	,
cord-300872-blycbi4u	507	42	solving	solve	VBG
cord-300872-blycbi4u	507	43	simple	simple	JJ
cord-300872-blycbi4u	507	44	problems	problem	NNS
cord-300872-blycbi4u	507	45	,	,	,
cord-300872-blycbi4u	507	46	and	and	CC
cord-300872-blycbi4u	507	47	trivial	trivial	JJ
cord-300872-blycbi4u	507	48	calculations	calculation	NNS
cord-300872-blycbi4u	507	49	.	.	.
cord-300872-blycbi4u	508	1	This	this	DT
cord-300872-blycbi4u	508	2	disease	disease	NN
cord-300872-blycbi4u	508	3	is	be	VBZ
cord-300872-blycbi4u	508	4	becoming	become	VBG
cord-300872-blycbi4u	508	5	a	a	DT
cord-300872-blycbi4u	508	6	universal	universal	JJ
cord-300872-blycbi4u	508	7	health	health	NN
cord-300872-blycbi4u	508	8	problem	problem	NN
cord-300872-blycbi4u	508	9	,	,	,
cord-300872-blycbi4u	508	10	and	and	CC
cord-300872-blycbi4u	508	11	it	-PRON-	PRP
cord-300872-blycbi4u	508	12	can	can	MD
cord-300872-blycbi4u	508	13	eventually	eventually	RB
cord-300872-blycbi4u	508	14	lead	lead	VB
cord-300872-blycbi4u	508	15	to	to	IN
cord-300872-blycbi4u	508	16	death	death	NN
cord-300872-blycbi4u	508	17	[	[	-LRB-
cord-300872-blycbi4u	508	18	48	48	CD
cord-300872-blycbi4u	508	19	]	]	-RRB-
cord-300872-blycbi4u	508	20	.	.	.
cord-300872-blycbi4u	509	1	Statistics	statistic	NNS
cord-300872-blycbi4u	509	2	indicate	indicate	VBP
cord-300872-blycbi4u	509	3	the	the	DT
cord-300872-blycbi4u	509	4	presence	presence	NN
cord-300872-blycbi4u	509	5	of	of	IN
cord-300872-blycbi4u	509	6	approximately	approximately	RB
cord-300872-blycbi4u	509	7	2.5	2.5	CD
cord-300872-blycbi4u	509	8	to	to	TO
cord-300872-blycbi4u	509	9	4.0	4.0	CD
cord-300872-blycbi4u	509	10	million	million	CD
cord-300872-blycbi4u	509	11	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	509	12	's	's	POS
cord-300872-blycbi4u	509	13	disease	disease	NN
cord-300872-blycbi4u	509	14	patients	patient	NNS
cord-300872-blycbi4u	509	15	in	in	IN
cord-300872-blycbi4u	509	16	the	the	DT
cord-300872-blycbi4u	509	17	United	United	NNP
cord-300872-blycbi4u	509	18	States	States	NNP
cord-300872-blycbi4u	509	19	,	,	,
cord-300872-blycbi4u	509	20	and	and	CC
cord-300872-blycbi4u	509	21	17	17	CD
cord-300872-blycbi4u	509	22	and	and	CC
cord-300872-blycbi4u	509	23	25	25	CD
cord-300872-blycbi4u	509	24	million	million	CD
cord-300872-blycbi4u	509	25	worldwide	worldwide	RB
cord-300872-blycbi4u	509	26	[	[	-LRB-
cord-300872-blycbi4u	509	27	49	49	CD
cord-300872-blycbi4u	509	28	]	]	-RRB-
cord-300872-blycbi4u	509	29	.	.	.
cord-300872-blycbi4u	510	1	Published	publish	VBN
cord-300872-blycbi4u	510	2	research	research	NN
cord-300872-blycbi4u	510	3	findings	finding	NNS
cord-300872-blycbi4u	510	4	indicate	indicate	VBP
cord-300872-blycbi4u	510	5	that	that	IN
cord-300872-blycbi4u	510	6	cholinergic	cholinergic	JJ
cord-300872-blycbi4u	510	7	dysfunction	dysfunction	NN
cord-300872-blycbi4u	510	8	could	could	MD
cord-300872-blycbi4u	510	9	be	be	VB
cord-300872-blycbi4u	510	10	associated	associate	VBN
cord-300872-blycbi4u	510	11	with	with	IN
cord-300872-blycbi4u	510	12	selective	selective	JJ
cord-300872-blycbi4u	510	13	and	and	CC
cord-300872-blycbi4u	510	14	irreversible	irreversible	JJ
cord-300872-blycbi4u	510	15	deficiency	deficiency	NN
cord-300872-blycbi4u	510	16	of	of	IN
cord-300872-blycbi4u	510	17	the	the	DT
cord-300872-blycbi4u	510	18	neurotransmitter	neurotransmitter	NN
cord-300872-blycbi4u	510	19	acetylcholine	acetylcholine	NN
cord-300872-blycbi4u	510	20	,	,	,
cord-300872-blycbi4u	510	21	which	which	WDT
cord-300872-blycbi4u	510	22	is	be	VBZ
cord-300872-blycbi4u	510	23	controlled	control	VBN
cord-300872-blycbi4u	510	24	by	by	IN
cord-300872-blycbi4u	510	25	hydrolysis	hydrolysis	NN
cord-300872-blycbi4u	510	26	of	of	IN
cord-300872-blycbi4u	510	27	acetylcholine	acetylcholine	NN
cord-300872-blycbi4u	510	28	via	via	IN
cord-300872-blycbi4u	510	29	acetylcholinestrase	acetylcholinestrase	NNP
cord-300872-blycbi4u	510	30	(	(	-LRB-
cord-300872-blycbi4u	510	31	AChE	ache	NN
cord-300872-blycbi4u	510	32	)	)	-RRB-
cord-300872-blycbi4u	510	33	and	and	CC
cord-300872-blycbi4u	510	34	butyrylcholinestrase	butyrylcholinestrase	NN
cord-300872-blycbi4u	510	35	(	(	-LRB-
cord-300872-blycbi4u	510	36	BChE	BChE	NNP
cord-300872-blycbi4u	510	37	)	)	-RRB-
cord-300872-blycbi4u	510	38	.	.	.
cord-300872-blycbi4u	511	1	Additionally	additionally	RB
cord-300872-blycbi4u	511	2	,	,	,
cord-300872-blycbi4u	511	3	it	-PRON-	PRP
cord-300872-blycbi4u	511	4	was	be	VBD
cord-300872-blycbi4u	511	5	suggested	suggest	VBN
cord-300872-blycbi4u	511	6	that	that	IN
cord-300872-blycbi4u	511	7	AChE	ache	NN
cord-300872-blycbi4u	511	8	predominates	predominate	VBZ
cord-300872-blycbi4u	511	9	in	in	IN
cord-300872-blycbi4u	511	10	a	a	DT
cord-300872-blycbi4u	511	11	healthy	healthy	JJ
cord-300872-blycbi4u	511	12	brain	brain	NN
cord-300872-blycbi4u	511	13	,	,	,
cord-300872-blycbi4u	511	14	whereas	whereas	IN
cord-300872-blycbi4u	511	15	BChE	BChE	NNP
cord-300872-blycbi4u	511	16	is	be	VBZ
cord-300872-blycbi4u	511	17	considered	consider	VBN
cord-300872-blycbi4u	511	18	to	to	TO
cord-300872-blycbi4u	511	19	play	play	VB
cord-300872-blycbi4u	511	20	a	a	DT
cord-300872-blycbi4u	511	21	minor	minor	JJ
cord-300872-blycbi4u	511	22	role	role	NN
cord-300872-blycbi4u	511	23	in	in	IN
cord-300872-blycbi4u	511	24	regulating	regulate	VBG
cord-300872-blycbi4u	511	25	the	the	DT
cord-300872-blycbi4u	511	26	brain	brain	NN
cord-300872-blycbi4u	511	27	's	's	POS
cord-300872-blycbi4u	511	28	ACh	ACh	NNP
cord-300872-blycbi4u	511	29	levels	level	NNS
cord-300872-blycbi4u	511	30	[	[	-LRB-
cord-300872-blycbi4u	511	31	49	49	CD
cord-300872-blycbi4u	511	32	]	]	-RRB-
cord-300872-blycbi4u	511	33	.	.	.
cord-300872-blycbi4u	512	1	The	the	DT
cord-300872-blycbi4u	512	2	approved	approve	VBN
cord-300872-blycbi4u	512	3	prescribed	prescribed	JJ
cord-300872-blycbi4u	512	4	commercial	commercial	JJ
cord-300872-blycbi4u	512	5	drugs	drug	NNS
cord-300872-blycbi4u	512	6	for	for	IN
cord-300872-blycbi4u	512	7	the	the	DT
cord-300872-blycbi4u	512	8	treatment	treatment	NN
cord-300872-blycbi4u	512	9	of	of	IN
cord-300872-blycbi4u	512	10	AD	ad	NN
cord-300872-blycbi4u	512	11	,	,	,
cord-300872-blycbi4u	512	12	which	which	WDT
cord-300872-blycbi4u	512	13	provide	provide	VBP
cord-300872-blycbi4u	512	14	slight	slight	JJ
cord-300872-blycbi4u	512	15	improvements	improvement	NNS
cord-300872-blycbi4u	512	16	in	in	IN
cord-300872-blycbi4u	512	17	memory	memory	NN
cord-300872-blycbi4u	512	18	,	,	,
cord-300872-blycbi4u	512	19	include	include	VBP
cord-300872-blycbi4u	512	20	donepezil	donepezil	NNP
cord-300872-blycbi4u	512	21	,	,	,
cord-300872-blycbi4u	512	22	rivastigmine	rivastigmine	NNP
cord-300872-blycbi4u	512	23	,	,	,
cord-300872-blycbi4u	512	24	and	and	CC
cord-300872-blycbi4u	512	25	others	other	NNS
cord-300872-blycbi4u	512	26	;	;	:
cord-300872-blycbi4u	512	27	their	-PRON-	PRP$
cord-300872-blycbi4u	512	28	action	action	NN
cord-300872-blycbi4u	512	29	is	be	VBZ
cord-300872-blycbi4u	512	30	based	base	VBN
cord-300872-blycbi4u	512	31	on	on	IN
cord-300872-blycbi4u	512	32	the	the	DT
cord-300872-blycbi4u	512	33	inhibition	inhibition	NN
cord-300872-blycbi4u	512	34	of	of	IN
cord-300872-blycbi4u	512	35	acetylcholinesterase	acetylcholinesterase	NN
cord-300872-blycbi4u	512	36	.	.	.
cord-300872-blycbi4u	513	1	It	-PRON-	PRP
cord-300872-blycbi4u	513	2	is	be	VBZ
cord-300872-blycbi4u	513	3	also	also	RB
cord-300872-blycbi4u	513	4	worth	worth	JJ
cord-300872-blycbi4u	513	5	mentioning	mention	VBG
cord-300872-blycbi4u	513	6	that	that	IN
cord-300872-blycbi4u	513	7	other	other	JJ
cord-300872-blycbi4u	513	8	factors	factor	NNS
cord-300872-blycbi4u	513	9	contribute	contribute	VBP
cord-300872-blycbi4u	513	10	to	to	IN
cord-300872-blycbi4u	513	11	AD	ad	NN
cord-300872-blycbi4u	513	12	,	,	,
cord-300872-blycbi4u	513	13	such	such	JJ
cord-300872-blycbi4u	513	14	as	as	IN
cord-300872-blycbi4u	513	15	β	β	NN
cord-300872-blycbi4u	513	16	-	-	HYPH
cord-300872-blycbi4u	513	17	amyloid	amyloid	NN
cord-300872-blycbi4u	513	18	(	(	-LRB-
cord-300872-blycbi4u	514	1	A	a	DT
cord-300872-blycbi4u	514	2	β	β	NN
cord-300872-blycbi4u	514	3	)	)	-RRB-
cord-300872-blycbi4u	514	4	deposits	deposit	NNS
cord-300872-blycbi4u	514	5	and	and	CC
cord-300872-blycbi4u	514	6	oxidative	oxidative	JJ
cord-300872-blycbi4u	514	7	stress	stress	NN
cord-300872-blycbi4u	514	8	.	.	.
cord-300872-blycbi4u	515	1	In	in	IN
cord-300872-blycbi4u	515	2	this	this	DT
cord-300872-blycbi4u	515	3	respect	respect	NN
cord-300872-blycbi4u	515	4	,	,	,
cord-300872-blycbi4u	515	5	several	several	JJ
cord-300872-blycbi4u	515	6	studies	study	NNS
cord-300872-blycbi4u	515	7	have	have	VBP
cord-300872-blycbi4u	515	8	shown	show	VBN
cord-300872-blycbi4u	515	9	that	that	IN
cord-300872-blycbi4u	515	10	levels	level	NNS
cord-300872-blycbi4u	515	11	of	of	IN
cord-300872-blycbi4u	515	12	redox	redox	NN
cord-300872-blycbi4u	515	13	-	-	HYPH
cord-300872-blycbi4u	515	14	active	active	JJ
cord-300872-blycbi4u	515	15	metal	metal	NN
cord-300872-blycbi4u	515	16	ions	ion	NNS
cord-300872-blycbi4u	515	17	,	,	,
cord-300872-blycbi4u	515	18	including	include	VBG
cord-300872-blycbi4u	515	19	Cu	Cu	NNP
cord-300872-blycbi4u	515	20	2	2	CD
cord-300872-blycbi4u	515	21	+	+	SYM
cord-300872-blycbi4u	515	22	and	and	CC
cord-300872-blycbi4u	515	23	Zn	Zn	NNP
cord-300872-blycbi4u	515	24	2	2	CD
cord-300872-blycbi4u	515	25	+	+	CC
cord-300872-blycbi4u	515	26	,	,	,
cord-300872-blycbi4u	515	27	are	be	VBP
cord-300872-blycbi4u	515	28	observed	observe	VBN
cord-300872-blycbi4u	515	29	in	in	IN
cord-300872-blycbi4u	515	30	the	the	DT
cord-300872-blycbi4u	515	31	brains	brain	NNS
cord-300872-blycbi4u	515	32	of	of	IN
cord-300872-blycbi4u	515	33	AD	ad	NN
cord-300872-blycbi4u	515	34	patients	patient	NNS
cord-300872-blycbi4u	515	35	[	[	-LRB-
cord-300872-blycbi4u	515	36	50	50	CD
cord-300872-blycbi4u	515	37	]	]	-RRB-
cord-300872-blycbi4u	515	38	.	.	.
cord-300872-blycbi4u	516	1	These	these	DT
cord-300872-blycbi4u	516	2	metal	metal	NN
cord-300872-blycbi4u	516	3	ions	ion	NNS
cord-300872-blycbi4u	516	4	can	can	MD
cord-300872-blycbi4u	516	5	interact	interact	VB
cord-300872-blycbi4u	516	6	with	with	IN
cord-300872-blycbi4u	516	7	β	β	NN
cord-300872-blycbi4u	516	8	-	-	HYPH
cord-300872-blycbi4u	516	9	amyloid	amyloid	NN
cord-300872-blycbi4u	516	10	peptides	peptide	NNS
cord-300872-blycbi4u	516	11	to	to	TO
cord-300872-blycbi4u	516	12	form	form	VB
cord-300872-blycbi4u	516	13	insoluble	insoluble	JJ
cord-300872-blycbi4u	516	14	plaques	plaque	NNS
cord-300872-blycbi4u	516	15	[	[	-LRB-
cord-300872-blycbi4u	516	16	51	51	CD
cord-300872-blycbi4u	516	17	,	,	,
cord-300872-blycbi4u	516	18	52	52	CD
cord-300872-blycbi4u	516	19	]	]	-RRB-
cord-300872-blycbi4u	516	20	.	.	.
cord-300872-blycbi4u	517	1	In	in	IN
cord-300872-blycbi4u	517	2	the	the	DT
cord-300872-blycbi4u	517	3	search	search	NN
cord-300872-blycbi4u	517	4	for	for	IN
cord-300872-blycbi4u	517	5	potent	potent	JJ
cord-300872-blycbi4u	517	6	BuChE	BuChE	NNS
cord-300872-blycbi4u	517	7	and	and	CC
cord-300872-blycbi4u	517	8	AChE	ache	NN
cord-300872-blycbi4u	517	9	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	517	10	,	,	,
cord-300872-blycbi4u	517	11	Hirbod	Hirbod	NNP
cord-300872-blycbi4u	517	12	et	et	NNP
cord-300872-blycbi4u	517	13	al	al	NNP
cord-300872-blycbi4u	517	14	.	.	.
cord-300872-blycbi4u	518	1	(	(	-LRB-
cord-300872-blycbi4u	518	2	2017	2017	CD
cord-300872-blycbi4u	518	3	)	)	-RRB-
cord-300872-blycbi4u	518	4	designed	design	VBN
cord-300872-blycbi4u	518	5	and	and	CC
cord-300872-blycbi4u	518	6	prepared	prepare	VBD
cord-300872-blycbi4u	518	7	eight	eight	CD
cord-300872-blycbi4u	518	8	novel	novel	JJ
cord-300872-blycbi4u	518	9	compounds	compound	NNS
cord-300872-blycbi4u	518	10	incorporating	incorporate	VBG
cord-300872-blycbi4u	518	11	coumarin	coumarin	NN
cord-300872-blycbi4u	518	12	and	and	CC
cord-300872-blycbi4u	518	13	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	518	14	moieties	moiety	NNS
cord-300872-blycbi4u	518	15	(	(	-LRB-
cord-300872-blycbi4u	518	16	73	73	CD
cord-300872-blycbi4u	518	17	)	)	-RRB-
cord-300872-blycbi4u	518	18	,	,	,
cord-300872-blycbi4u	518	19	as	as	IN
cord-300872-blycbi4u	518	20	shown	show	VBN
cord-300872-blycbi4u	518	21	in	in	IN
cord-300872-blycbi4u	518	22	the	the	DT
cord-300872-blycbi4u	518	23	[	[	-LRB-
cord-300872-blycbi4u	518	24	53	53	CD
cord-300872-blycbi4u	518	25	]	]	-RRB-
cord-300872-blycbi4u	518	26	.	.	.
cord-300872-blycbi4u	519	1	These	these	DT
cord-300872-blycbi4u	519	2	researchers	researcher	NNS
cord-300872-blycbi4u	519	3	used	use	VBD
cord-300872-blycbi4u	519	4	various	various	JJ
cord-300872-blycbi4u	519	5	dibromoalkanes	dibromoalkane	NNS
cord-300872-blycbi4u	519	6	(	(	-LRB-
cord-300872-blycbi4u	519	7	n	n	NN
cord-300872-blycbi4u	519	8	=	=	SYM
cord-300872-blycbi4u	519	9	3	3	CD
cord-300872-blycbi4u	519	10	-	-	SYM
cord-300872-blycbi4u	519	11	5	5	CD
cord-300872-blycbi4u	519	12	)	)	-RRB-
cord-300872-blycbi4u	519	13	as	as	IN
cord-300872-blycbi4u	519	14	cross	cross	NN
cord-300872-blycbi4u	519	15	-	-	NNS
cord-300872-blycbi4u	519	16	linkers	linker	NNS
cord-300872-blycbi4u	519	17	between	between	IN
cord-300872-blycbi4u	519	18	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	519	19	and	and	CC
cord-300872-blycbi4u	519	20	coumarin	coumarin	NN
cord-300872-blycbi4u	519	21	rings	ring	NNS
cord-300872-blycbi4u	519	22	in	in	IN
cord-300872-blycbi4u	519	23	the	the	DT
cord-300872-blycbi4u	519	24	presence	presence	NN
cord-300872-blycbi4u	519	25	of	of	IN
cord-300872-blycbi4u	519	26	an	an	DT
cord-300872-blycbi4u	519	27	aprotic	aprotic	JJ
cord-300872-blycbi4u	519	28	solvent	solvent	NN
cord-300872-blycbi4u	519	29	(	(	-LRB-
cord-300872-blycbi4u	519	30	N	N	NNP
cord-300872-blycbi4u	519	31	,	,	,
cord-300872-blycbi4u	519	32	N	n	NN
cord-300872-blycbi4u	519	33	-	-	HYPH
cord-300872-blycbi4u	519	34	dimethylformamide	dimethylformamide	RB
cord-300872-blycbi4u	519	35	)	)	-RRB-
cord-300872-blycbi4u	519	36	.	.	.
cord-300872-blycbi4u	520	1	In	in	IN
cord-300872-blycbi4u	520	2	addition	addition	NN
cord-300872-blycbi4u	520	3	,	,	,
cord-300872-blycbi4u	520	4	the	the	DT
cord-300872-blycbi4u	520	5	activity	activity	NN
cord-300872-blycbi4u	520	6	levels	level	NNS
cord-300872-blycbi4u	520	7	of	of	IN
cord-300872-blycbi4u	520	8	these	these	DT
cord-300872-blycbi4u	520	9	prepared	prepared	JJ
cord-300872-blycbi4u	520	10	compounds	compound	NNS
cord-300872-blycbi4u	520	11	were	be	VBD
cord-300872-blycbi4u	520	12	evaluated	evaluate	VBN
cord-300872-blycbi4u	520	13	against	against	IN
cord-300872-blycbi4u	520	14	BuChE	buche	NN
cord-300872-blycbi4u	520	15	and	and	CC
cord-300872-blycbi4u	520	16	AChE	ache	NN
cord-300872-blycbi4u	520	17	using	use	VBG
cord-300872-blycbi4u	520	18	Ellman	Ellman	NNP
cord-300872-blycbi4u	520	19	's	's	POS
cord-300872-blycbi4u	520	20	method	method	NN
cord-300872-blycbi4u	520	21	.	.	.
cord-300872-blycbi4u	521	1	The	the	DT
cord-300872-blycbi4u	521	2	results	result	NNS
cord-300872-blycbi4u	521	3	demonstrated	demonstrate	VBD
cord-300872-blycbi4u	521	4	that	that	IN
cord-300872-blycbi4u	521	5	some	some	DT
cord-300872-blycbi4u	521	6	of	of	IN
cord-300872-blycbi4u	521	7	the	the	DT
cord-300872-blycbi4u	521	8	prepared	prepared	JJ
cord-300872-blycbi4u	521	9	compounds	compound	NNS
cord-300872-blycbi4u	521	10	exhibited	exhibit	VBD
cord-300872-blycbi4u	521	11	potent	potent	JJ
cord-300872-blycbi4u	521	12	AChE	ache	NN
cord-300872-blycbi4u	521	13	and	and	CC
cord-300872-blycbi4u	521	14	BuCHE	BuCHE	NNP
cord-300872-blycbi4u	521	15	inhibition	inhibition	NN
cord-300872-blycbi4u	521	16	activities	activity	NNS
cord-300872-blycbi4u	521	17	,	,	,
cord-300872-blycbi4u	521	18	with	with	IN
cord-300872-blycbi4u	521	19	half	half	RB
cord-300872-blycbi4u	521	20	-	-	HYPH
cord-300872-blycbi4u	521	21	maximal	maximal	JJ
cord-300872-blycbi4u	521	22	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	521	23	concentration	concentration	NN
cord-300872-blycbi4u	521	24	(	(	-LRB-
cord-300872-blycbi4u	521	25	IC	IC	NNP
cord-300872-blycbi4u	521	26	50	50	CD
cord-300872-blycbi4u	521	27	(	(	-LRB-
cord-300872-blycbi4u	521	28	74	74	CD
cord-300872-blycbi4u	521	29	and	and	CC
cord-300872-blycbi4u	521	30	75	75	CD
cord-300872-blycbi4u	521	31	)	)	-RRB-
cord-300872-blycbi4u	521	32	,	,	,
cord-300872-blycbi4u	521	33	as	as	IN
cord-300872-blycbi4u	521	34	shown	show	VBN
cord-300872-blycbi4u	521	35	in	in	IN
cord-300872-blycbi4u	521	36	Figure	figure	NN
cord-300872-blycbi4u	521	37	5	5	CD
cord-300872-blycbi4u	521	38	[	[	-LRB-
cord-300872-blycbi4u	521	39	54	54	CD
cord-300872-blycbi4u	521	40	]	]	-RRB-
cord-300872-blycbi4u	521	41	.	.	.
cord-300872-blycbi4u	522	1	The	the	DT
cord-300872-blycbi4u	522	2	target	target	NN
cord-300872-blycbi4u	522	3	compounds	compound	NNS
cord-300872-blycbi4u	522	4	were	be	VBD
cord-300872-blycbi4u	522	5	prepared	prepare	VBN
cord-300872-blycbi4u	522	6	by	by	IN
cord-300872-blycbi4u	522	7	chloromethylation	chloromethylation	NN
cord-300872-blycbi4u	522	8	of	of	IN
cord-300872-blycbi4u	522	9	8-HQ	8-hq	CD
cord-300872-blycbi4u	522	10	to	to	TO
cord-300872-blycbi4u	522	11	give	give	VB
cord-300872-blycbi4u	522	12	5-chloromethyl-8-hydroxyquinoline	5-chloromethyl-8-hydroxyquinoline	CD
cord-300872-blycbi4u	522	13	.	.	.
cord-300872-blycbi4u	523	1	Then	then	RB
cord-300872-blycbi4u	523	2	,	,	,
cord-300872-blycbi4u	523	3	the	the	DT
cord-300872-blycbi4u	523	4	former	former	JJ
cord-300872-blycbi4u	523	5	compound	compound	NN
cord-300872-blycbi4u	523	6	was	be	VBD
cord-300872-blycbi4u	523	7	reacted	react	VBN
cord-300872-blycbi4u	523	8	with	with	IN
cord-300872-blycbi4u	523	9	tert	tert	NNP
cord-300872-blycbi4u	523	10	-	-	HYPH
cord-300872-blycbi4u	523	11	butylpiperazine-1-carboxylate	butylpiperazine-1-carboxylate	NNP
cord-300872-blycbi4u	523	12	followed	follow	VBN
cord-300872-blycbi4u	523	13	by	by	IN
cord-300872-blycbi4u	523	14	trifluoroacetic	trifluoroacetic	JJ
cord-300872-blycbi4u	523	15	acid	acid	NN
cord-300872-blycbi4u	523	16	to	to	TO
cord-300872-blycbi4u	523	17	remove	remove	VB
cord-300872-blycbi4u	523	18	the	the	DT
cord-300872-blycbi4u	523	19	protected	protect	VBN
cord-300872-blycbi4u	523	20	Boc	Boc	NNP
cord-300872-blycbi4u	523	21	group	group	NN
cord-300872-blycbi4u	523	22	.	.	.
cord-300872-blycbi4u	524	1	Finally	finally	RB
cord-300872-blycbi4u	524	2	,	,	,
cord-300872-blycbi4u	524	3	the	the	DT
cord-300872-blycbi4u	524	4	resulting	result	VBG
cord-300872-blycbi4u	524	5	compound	compound	NN
cord-300872-blycbi4u	524	6	was	be	VBD
cord-300872-blycbi4u	524	7	reacted	react	VBN
cord-300872-blycbi4u	524	8	with	with	IN
cord-300872-blycbi4u	524	9	the	the	DT
cord-300872-blycbi4u	524	10	appropriate	appropriate	JJ
cord-300872-blycbi4u	524	11	cinnamic	cinnamic	NN
cord-300872-blycbi4u	524	12	or	or	CC
cord-300872-blycbi4u	524	13	hydroxycinnamic	hydroxycinnamic	JJ
cord-300872-blycbi4u	524	14	acids	acid	NNS
cord-300872-blycbi4u	524	15	,	,	,
cord-300872-blycbi4u	524	16	using	use	VBG
cord-300872-blycbi4u	524	17	1-ethyl-3-(3-dimethylaminopropyl)carbodiimide	1-ethyl-3-(3-dimethylaminopropyl)carbodiimide	CD
cord-300872-blycbi4u	524	18	(	(	-LRB-
cord-300872-blycbi4u	524	19	EDC	EDC	NNP
cord-300872-blycbi4u	524	20	)	)	-RRB-
cord-300872-blycbi4u	524	21	.	.	.
cord-300872-blycbi4u	525	1	In	in	IN
cord-300872-blycbi4u	525	2	this	this	DT
cord-300872-blycbi4u	525	3	context	context	NN
cord-300872-blycbi4u	525	4	,	,	,
cord-300872-blycbi4u	525	5	β	β	NN
cord-300872-blycbi4u	525	6	-	-	HYPH
cord-300872-blycbi4u	525	7	amyloid	amyloid	NNP
cord-300872-blycbi4u	525	8	(	(	-LRB-
cord-300872-blycbi4u	525	9	Aβ	Aβ	NNP
cord-300872-blycbi4u	525	10	)	)	-RRB-
cord-300872-blycbi4u	525	11	significantly	significantly	RB
cord-300872-blycbi4u	525	12	contributed	contribute	VBD
cord-300872-blycbi4u	525	13	to	to	IN
cord-300872-blycbi4u	525	14	the	the	DT
cord-300872-blycbi4u	525	15	progression	progression	NN
cord-300872-blycbi4u	525	16	of	of	IN
cord-300872-blycbi4u	525	17	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	525	18	's	's	POS
cord-300872-blycbi4u	525	19	disease	disease	NN
cord-300872-blycbi4u	525	20	(	(	-LRB-
cord-300872-blycbi4u	525	21	AD	ad	NN
cord-300872-blycbi4u	525	22	)	)	-RRB-
cord-300872-blycbi4u	525	23	,	,	,
cord-300872-blycbi4u	525	24	where	where	WRB
cord-300872-blycbi4u	525	25	elevated	elevated	JJ
cord-300872-blycbi4u	525	26	levels	level	NNS
cord-300872-blycbi4u	525	27	of	of	IN
cord-300872-blycbi4u	525	28	Aβ	Aβ	NNP
cord-300872-blycbi4u	525	29	have	have	VBP
cord-300872-blycbi4u	525	30	been	be	VBN
cord-300872-blycbi4u	525	31	detected	detect	VBN
cord-300872-blycbi4u	525	32	in	in	IN
cord-300872-blycbi4u	525	33	the	the	DT
cord-300872-blycbi4u	525	34	brains	brain	NNS
cord-300872-blycbi4u	525	35	of	of	IN
cord-300872-blycbi4u	525	36	AD	ad	NN
cord-300872-blycbi4u	525	37	patients	patient	NNS
cord-300872-blycbi4u	525	38	.	.	.
cord-300872-blycbi4u	526	1	Moreover	moreover	RB
cord-300872-blycbi4u	526	2	,	,	,
cord-300872-blycbi4u	526	3	Aβ	Aβ	NNP
cord-300872-blycbi4u	526	4	A	a	DT
cord-300872-blycbi4u	526	5	aggregation	aggregation	NN
cord-300872-blycbi4u	526	6	can	can	MD
cord-300872-blycbi4u	526	7	be	be	VB
cord-300872-blycbi4u	526	8	clearly	clearly	RB
cord-300872-blycbi4u	526	9	observed	observe	VBN
cord-300872-blycbi4u	526	10	in	in	IN
cord-300872-blycbi4u	526	11	the	the	DT
cord-300872-blycbi4u	526	12	presence	presence	NN
cord-300872-blycbi4u	526	13	of	of	IN
cord-300872-blycbi4u	526	14	Cu	Cu	NNP
cord-300872-blycbi4u	526	15	2	2	CD
cord-300872-blycbi4u	527	1	+	+	CC
cord-300872-blycbi4u	527	2	,	,	,
cord-300872-blycbi4u	527	3	Zn	Zn	NNP
cord-300872-blycbi4u	527	4	2	2	CD
cord-300872-blycbi4u	528	1	+	+	UH
cord-300872-blycbi4u	528	2	,	,	,
cord-300872-blycbi4u	528	3	and	and	CC
cord-300872-blycbi4u	528	4	Fe	Fe	NNP
cord-300872-blycbi4u	528	5	2	2	CD
cord-300872-blycbi4u	528	6	+	+	SYM
cord-300872-blycbi4u	528	7	ions	ion	NNS
cord-300872-blycbi4u	528	8	,	,	,
cord-300872-blycbi4u	528	9	since	since	IN
cord-300872-blycbi4u	528	10	these	these	DT
cord-300872-blycbi4u	528	11	ions	ion	NNS
cord-300872-blycbi4u	528	12	can	can	MD
cord-300872-blycbi4u	528	13	readily	readily	RB
cord-300872-blycbi4u	528	14	bind	bind	VB
cord-300872-blycbi4u	528	15	to	to	IN
cord-300872-blycbi4u	528	16	Aβ	Aβ	NNP
cord-300872-blycbi4u	528	17	through	through	IN
cord-300872-blycbi4u	528	18	some	some	DT
cord-300872-blycbi4u	528	19	of	of	IN
cord-300872-blycbi4u	528	20	its	-PRON-	PRP$
cord-300872-blycbi4u	528	21	specific	specific	JJ
cord-300872-blycbi4u	528	22	residues	residue	NNS
cord-300872-blycbi4u	528	23	.	.	.
cord-300872-blycbi4u	529	1	In	in	IN
cord-300872-blycbi4u	529	2	addition	addition	NN
cord-300872-blycbi4u	529	3	,	,	,
cord-300872-blycbi4u	529	4	Aβ	Aβ	NNP
cord-300872-blycbi4u	529	5	can	can	MD
cord-300872-blycbi4u	529	6	aggregate	aggregate	VB
cord-300872-blycbi4u	529	7	by	by	IN
cord-300872-blycbi4u	529	8	itself	-PRON-	PRP
cord-300872-blycbi4u	529	9	.	.	.
cord-300872-blycbi4u	530	1	Th	th	DT
cord-300872-blycbi4u	530	2	prepared	prepared	JJ
cord-300872-blycbi4u	530	3	target	target	NN
cord-300872-blycbi4u	530	4	compounds	compound	NNS
cord-300872-blycbi4u	530	5	were	be	VBD
cord-300872-blycbi4u	530	6	tested	test	VBN
cord-300872-blycbi4u	530	7	for	for	IN
cord-300872-blycbi4u	530	8	their	-PRON-	PRP$
cord-300872-blycbi4u	530	9	inhibition	inhibition	NN
cord-300872-blycbi4u	530	10	of	of	IN
cord-300872-blycbi4u	530	11	Aβ	Aβ	NNP
cord-300872-blycbi4u	530	12	aggregation	aggregation	NN
cord-300872-blycbi4u	530	13	using	use	VBG
cord-300872-blycbi4u	530	14	the	the	DT
cord-300872-blycbi4u	530	15	thioflavon	thioflavon	NN
cord-300872-blycbi4u	530	16	T	t	NN
cord-300872-blycbi4u	530	17	-	-	HYPH
cord-300872-blycbi4u	530	18	binding	bind	VBG
cord-300872-blycbi4u	530	19	assay	assay	NN
cord-300872-blycbi4u	530	20	[	[	-LRB-
cord-300872-blycbi4u	530	21	55	55	CD
cord-300872-blycbi4u	530	22	,	,	,
cord-300872-blycbi4u	530	23	56	56	CD
cord-300872-blycbi4u	530	24	]	]	-RRB-
cord-300872-blycbi4u	530	25	.	.	.
cord-300872-blycbi4u	531	1	Furthermore	furthermore	RB
cord-300872-blycbi4u	531	2	,	,	,
cord-300872-blycbi4u	531	3	chelating	chelating	NN
cord-300872-blycbi4u	531	4	studies	study	NNS
cord-300872-blycbi4u	531	5	of	of	IN
cord-300872-blycbi4u	531	6	Cu	Cu	NNP
cord-300872-blycbi4u	531	7	2	2	CD
cord-300872-blycbi4u	532	1	+	+	CC
cord-300872-blycbi4u	532	2	,	,	,
cord-300872-blycbi4u	532	3	Zn	Zn	NNP
cord-300872-blycbi4u	532	4	2	2	CD
cord-300872-blycbi4u	533	1	+	+	CC
cord-300872-blycbi4u	534	1	,	,	,
cord-300872-blycbi4u	534	2	Fe	Fe	NNP
cord-300872-blycbi4u	534	3	3	3	CD
cord-300872-blycbi4u	534	4	+	+	CC
cord-300872-blycbi4u	534	5	,	,	,
cord-300872-blycbi4u	534	6	and	and	CC
cord-300872-blycbi4u	534	7	Fe	Fe	NNP
cord-300872-blycbi4u	534	8	2	2	CD
cord-300872-blycbi4u	534	9	+	+	SYM
cord-300872-blycbi4u	534	10	were	be	VBD
cord-300872-blycbi4u	534	11	conducted	conduct	VBN
cord-300872-blycbi4u	534	12	using	use	VBG
cord-300872-blycbi4u	534	13	the	the	DT
cord-300872-blycbi4u	534	14	former	former	JJ
cord-300872-blycbi4u	534	15	prepared	prepared	JJ
cord-300872-blycbi4u	534	16	derivatives	derivative	NNS
cord-300872-blycbi4u	534	17	by	by	IN
cord-300872-blycbi4u	534	18	means	mean	NNS
cord-300872-blycbi4u	534	19	of	of	IN
cord-300872-blycbi4u	534	20	a	a	DT
cord-300872-blycbi4u	534	21	UV	uv	NN
cord-300872-blycbi4u	534	22	-	-	HYPH
cord-300872-blycbi4u	534	23	Vis	vis	NN
cord-300872-blycbi4u	534	24	spectrophotometer	spectrophotometer	NN
cord-300872-blycbi4u	534	25	.	.	.
cord-300872-blycbi4u	535	1	The	the	DT
cord-300872-blycbi4u	535	2	results	result	NNS
cord-300872-blycbi4u	535	3	revealed	reveal	VBD
cord-300872-blycbi4u	535	4	that	that	IN
cord-300872-blycbi4u	535	5	the	the	DT
cord-300872-blycbi4u	535	6	compound	compound	NN
cord-300872-blycbi4u	535	7	designated	designate	VBN
cord-300872-blycbi4u	535	8	with	with	IN
cord-300872-blycbi4u	535	9	R	r	NN
cord-300872-blycbi4u	535	10	1	1	CD
cord-300872-blycbi4u	535	11	=	=	SYM
cord-300872-blycbi4u	535	12	H	h	NN
cord-300872-blycbi4u	535	13	,	,	,
cord-300872-blycbi4u	535	14	R	r	NN
cord-300872-blycbi4u	535	15	2	2	CD
cord-300872-blycbi4u	535	16	,	,	,
cord-300872-blycbi4u	535	17	R	r	NN
cord-300872-blycbi4u	535	18	3	3	CD
cord-300872-blycbi4u	536	1	=	=	NFP
cord-300872-blycbi4u	537	1	OCH	OCH	NNP
cord-300872-blycbi4u	537	2	3	3	CD
cord-300872-blycbi4u	537	3	showed	show	VBD
cord-300872-blycbi4u	537	4	the	the	DT
cord-300872-blycbi4u	537	5	maximum	maximum	JJ
cord-300872-blycbi4u	537	6	percentage	percentage	NN
cord-300872-blycbi4u	537	7	inhibition	inhibition	NN
cord-300872-blycbi4u	537	8	of	of	IN
cord-300872-blycbi4u	537	9	Aβ	Aβ	NNP
cord-300872-blycbi4u	537	10	1→42	1→42	CD
cord-300872-blycbi4u	537	11	aggregation	aggregation	NN
cord-300872-blycbi4u	537	12	of	of	IN
cord-300872-blycbi4u	537	13	65.82	65.82	CD
cord-300872-blycbi4u	537	14	%	%	NN
cord-300872-blycbi4u	537	15	with	with	IN
cord-300872-blycbi4u	537	16	an	an	DT
cord-300872-blycbi4u	537	17	IC	IC	NNP
cord-300872-blycbi4u	537	18	50	50	CD
cord-300872-blycbi4u	537	19	of	of	IN
cord-300872-blycbi4u	537	20	5.64	5.64	CD
cord-300872-blycbi4u	537	21	mM	mm	CD
cord-300872-blycbi4u	537	22	compared	compare	VBN
cord-300872-blycbi4u	537	23	to	to	IN
cord-300872-blycbi4u	537	24	resveratrol	resveratrol	NN
cord-300872-blycbi4u	537	25	,	,	,
cord-300872-blycbi4u	537	26	which	which	WDT
cord-300872-blycbi4u	537	27	showed	show	VBD
cord-300872-blycbi4u	537	28	corresponding	corresponding	JJ
cord-300872-blycbi4u	537	29	values	value	NNS
cord-300872-blycbi4u	537	30	of	of	IN
cord-300872-blycbi4u	537	31	51.74	51.74	CD
cord-300872-blycbi4u	537	32	%	%	NN
cord-300872-blycbi4u	537	33	and	and	CC
cord-300872-blycbi4u	537	34	12.43	12.43	CD
cord-300872-blycbi4u	537	35	mM.	mm.	NN
cord-300872-blycbi4u	538	1	In	in	IN
cord-300872-blycbi4u	538	2	addition	addition	NN
cord-300872-blycbi4u	538	3	,	,	,
cord-300872-blycbi4u	538	4	the	the	DT
cord-300872-blycbi4u	538	5	previous	previous	JJ
cord-300872-blycbi4u	538	6	compound	compound	NN
cord-300872-blycbi4u	538	7	was	be	VBD
cord-300872-blycbi4u	538	8	selected	select	VBN
cord-300872-blycbi4u	538	9	as	as	IN
cord-300872-blycbi4u	538	10	a	a	DT
cord-300872-blycbi4u	538	11	representative	representative	NN
cord-300872-blycbi4u	538	12	to	to	TO
cord-300872-blycbi4u	538	13	examine	examine	VB
cord-300872-blycbi4u	538	14	its	-PRON-	PRP$
cord-300872-blycbi4u	538	15	metal	metal	NN
cord-300872-blycbi4u	538	16	chelation	chelation	NN
cord-300872-blycbi4u	538	17	behavior	behavior	NN
cord-300872-blycbi4u	538	18	;	;	:
cord-300872-blycbi4u	538	19	it	-PRON-	PRP
cord-300872-blycbi4u	538	20	exhibited	exhibit	VBD
cord-300872-blycbi4u	538	21	significant	significant	JJ
cord-300872-blycbi4u	538	22	activity	activity	NN
cord-300872-blycbi4u	538	23	in	in	IN
cord-300872-blycbi4u	538	24	this	this	DT
cord-300872-blycbi4u	538	25	context	context	NN
cord-300872-blycbi4u	538	26	,	,	,
cord-300872-blycbi4u	538	27	producing	produce	VBG
cord-300872-blycbi4u	538	28	even	even	RB
cord-300872-blycbi4u	538	29	better	well	JJR
cord-300872-blycbi4u	538	30	results	result	NNS
cord-300872-blycbi4u	538	31	than	than	IN
cord-300872-blycbi4u	538	32	clioquinol	clioquinol	NN
cord-300872-blycbi4u	538	33	.	.	.
cord-300872-blycbi4u	539	1	Molecules	molecule	NNS
cord-300872-blycbi4u	539	2	2020	2020	CD
cord-300872-blycbi4u	539	3	,	,	,
cord-300872-blycbi4u	539	4	25	25	CD
cord-300872-blycbi4u	539	5	[	[	-LRB-
cord-300872-blycbi4u	539	6	57	57	CD
cord-300872-blycbi4u	539	7	]	]	-RRB-
cord-300872-blycbi4u	539	8	.	.	.
cord-300872-blycbi4u	540	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	540	2	of	of	IN
cord-300872-blycbi4u	540	3	these	these	DT
cord-300872-blycbi4u	540	4	compounds	compound	NNS
cord-300872-blycbi4u	540	5	involved	involve	VBD
cord-300872-blycbi4u	540	6	protection	protection	NN
cord-300872-blycbi4u	540	7	of	of	IN
cord-300872-blycbi4u	540	8	the	the	DT
cord-300872-blycbi4u	540	9	phenolic	phenolic	JJ
cord-300872-blycbi4u	540	10	group	group	NN
cord-300872-blycbi4u	540	11	in	in	IN
cord-300872-blycbi4u	540	12	76	76	CD
cord-300872-blycbi4u	540	13	using	use	VBG
cord-300872-blycbi4u	540	14	Boc	Boc	NNP
cord-300872-blycbi4u	540	15	group	group	NN
cord-300872-blycbi4u	540	16	to	to	TO
cord-300872-blycbi4u	540	17	allow	allow	VB
cord-300872-blycbi4u	540	18	the	the	DT
cord-300872-blycbi4u	540	19	reaction	reaction	NN
cord-300872-blycbi4u	540	20	of	of	IN
cord-300872-blycbi4u	540	21	the	the	DT
cord-300872-blycbi4u	540	22	primary	primary	JJ
cord-300872-blycbi4u	540	23	aromatic	aromatic	JJ
cord-300872-blycbi4u	540	24	amine	amine	NN
cord-300872-blycbi4u	540	25	in	in	IN
cord-300872-blycbi4u	540	26	77	77	CD
cord-300872-blycbi4u	540	27	with	with	IN
cord-300872-blycbi4u	540	28	substituted	substitute	VBN
cord-300872-blycbi4u	540	29	benzoyl	benzoyl	JJ
cord-300872-blycbi4u	540	30	chlorides	chloride	NNS
cord-300872-blycbi4u	540	31	in	in	IN
cord-300872-blycbi4u	540	32	the	the	DT
cord-300872-blycbi4u	540	33	presence	presence	NN
cord-300872-blycbi4u	540	34	of	of	IN
cord-300872-blycbi4u	540	35	triethylamine	triethylamine	NN
cord-300872-blycbi4u	540	36	(	(	-LRB-
cord-300872-blycbi4u	540	37	TEA	tea	NN
cord-300872-blycbi4u	540	38	)	)	-RRB-
cord-300872-blycbi4u	540	39	as	as	IN
cord-300872-blycbi4u	540	40	the	the	DT
cord-300872-blycbi4u	540	41	base	base	NN
cord-300872-blycbi4u	540	42	and	and	CC
cord-300872-blycbi4u	540	43	catalyst	catalyst	NN
cord-300872-blycbi4u	540	44	to	to	TO
cord-300872-blycbi4u	540	45	form	form	VB
cord-300872-blycbi4u	540	46	the	the	DT
cord-300872-blycbi4u	540	47	carboxamide	carboxamide	JJ
cord-300872-blycbi4u	540	48	group	group	NN
cord-300872-blycbi4u	540	49	78	78	CD
cord-300872-blycbi4u	540	50	.	.	.
cord-300872-blycbi4u	541	1	In	in	IN
cord-300872-blycbi4u	541	2	the	the	DT
cord-300872-blycbi4u	541	3	final	final	JJ
cord-300872-blycbi4u	541	4	step	step	NN
cord-300872-blycbi4u	541	5	,	,	,
cord-300872-blycbi4u	541	6	deprotection	deprotection	NN
cord-300872-blycbi4u	541	7	of	of	IN
cord-300872-blycbi4u	541	8	the	the	DT
cord-300872-blycbi4u	541	9	Boc	Boc	NNP
cord-300872-blycbi4u	541	10	group	group	NN
cord-300872-blycbi4u	541	11	was	be	VBD
cord-300872-blycbi4u	541	12	accomplished	accomplish	VBN
cord-300872-blycbi4u	541	13	with	with	IN
cord-300872-blycbi4u	541	14	hydrogen	hydrogen	NN
cord-300872-blycbi4u	541	15	chloride	chloride	NN
cord-300872-blycbi4u	541	16	to	to	TO
cord-300872-blycbi4u	541	17	afford	afford	VB
cord-300872-blycbi4u	541	18	the	the	DT
cord-300872-blycbi4u	541	19	desired	desire	VBN
cord-300872-blycbi4u	541	20	products	product	NNS
cord-300872-blycbi4u	541	21	as	as	IN
cord-300872-blycbi4u	541	22	salt	salt	NN
cord-300872-blycbi4u	541	23	79	79	CD
cord-300872-blycbi4u	541	24	.	.	.
cord-300872-blycbi4u	542	1	Regarding	regard	VBG
cord-300872-blycbi4u	542	2	Scheme	Scheme	NNP
cord-300872-blycbi4u	542	3	20	20	CD
cord-300872-blycbi4u	542	4	,	,	,
cord-300872-blycbi4u	542	5	the	the	DT
cord-300872-blycbi4u	542	6	phenoxide	phenoxide	JJ
cord-300872-blycbi4u	542	7	anion	anion	NN
cord-300872-blycbi4u	542	8	in	in	IN
cord-300872-blycbi4u	542	9	80	80	CD
cord-300872-blycbi4u	542	10	was	be	VBD
cord-300872-blycbi4u	542	11	formed	form	VBN
cord-300872-blycbi4u	542	12	in	in	IN
cord-300872-blycbi4u	542	13	situ	situ	NN
cord-300872-blycbi4u	542	14	by	by	IN
cord-300872-blycbi4u	542	15	reaction	reaction	NN
cord-300872-blycbi4u	542	16	of	of	IN
cord-300872-blycbi4u	542	17	the	the	DT
cord-300872-blycbi4u	542	18	phenolic	phenolic	JJ
cord-300872-blycbi4u	542	19	group	group	NN
cord-300872-blycbi4u	542	20	with	with	IN
cord-300872-blycbi4u	542	21	potassium	potassium	NN
cord-300872-blycbi4u	542	22	carbonate	carbonate	NN
cord-300872-blycbi4u	542	23	(	(	-LRB-
cord-300872-blycbi4u	542	24	base	base	NN
cord-300872-blycbi4u	542	25	)	)	-RRB-
cord-300872-blycbi4u	542	26	,	,	,
cord-300872-blycbi4u	542	27	which	which	WDT
cord-300872-blycbi4u	542	28	then	then	RB
cord-300872-blycbi4u	542	29	reacts	react	VBZ
cord-300872-blycbi4u	542	30	with	with	IN
cord-300872-blycbi4u	542	31	benzyl	benzyl	NN
cord-300872-blycbi4u	542	32	bromide	bromide	NN
cord-300872-blycbi4u	542	33	.	.	.
cord-300872-blycbi4u	543	1	The	the	DT
cord-300872-blycbi4u	543	2	methyl	methyl	NN
cord-300872-blycbi4u	543	3	group	group	NN
cord-300872-blycbi4u	543	4	in	in	IN
cord-300872-blycbi4u	543	5	81	81	CD
cord-300872-blycbi4u	543	6	was	be	VBD
cord-300872-blycbi4u	543	7	then	then	RB
cord-300872-blycbi4u	543	8	subjected	subject	VBN
cord-300872-blycbi4u	543	9	to	to	IN
cord-300872-blycbi4u	543	10	Pinnick	Pinnick	NNP
cord-300872-blycbi4u	543	11	oxidation	oxidation	NN
cord-300872-blycbi4u	543	12	using	use	VBG
cord-300872-blycbi4u	543	13	SeO2	SeO2	NNS
cord-300872-blycbi4u	543	14	to	to	TO
cord-300872-blycbi4u	543	15	afford	afford	VB
cord-300872-blycbi4u	543	16	the	the	DT
cord-300872-blycbi4u	543	17	corresponding	corresponding	JJ
cord-300872-blycbi4u	543	18	acid	acid	NN
cord-300872-blycbi4u	543	19	82	82	CD
cord-300872-blycbi4u	543	20	.	.	.
cord-300872-blycbi4u	544	1	Reaction	reaction	NN
cord-300872-blycbi4u	544	2	of	of	IN
cord-300872-blycbi4u	544	3	the	the	DT
cord-300872-blycbi4u	544	4	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	544	5	acid	acid	NN
cord-300872-blycbi4u	544	6	group	group	NN
cord-300872-blycbi4u	544	7	in	in	IN
cord-300872-blycbi4u	544	8	82	82	CD
cord-300872-blycbi4u	544	9	with	with	IN
cord-300872-blycbi4u	544	10	thionyl	thionyl	NNP
cord-300872-blycbi4u	544	11	chloride	chloride	NN
cord-300872-blycbi4u	544	12	and	and	CC
cord-300872-blycbi4u	544	13	then	then	RB
cord-300872-blycbi4u	544	14	with	with	IN
cord-300872-blycbi4u	544	15	3-(cyclopentyloxy)-4-methoxyaniline	3-(cyclopentyloxy)-4-methoxyaniline	CD
cord-300872-blycbi4u	544	16	or	or	CC
cord-300872-blycbi4u	544	17	3,4-dimethoxyaniline	3,4-dimethoxyaniline	CD
cord-300872-blycbi4u	544	18	afforded	afford	VBN
cord-300872-blycbi4u	544	19	83	83	CD
cord-300872-blycbi4u	544	20	upon	upon	IN
cord-300872-blycbi4u	544	21	removal	removal	NN
cord-300872-blycbi4u	544	22	of	of	IN
cord-300872-blycbi4u	544	23	Bn	Bn	NNP
cord-300872-blycbi4u	544	24	with	with	IN
cord-300872-blycbi4u	544	25	hydrogen	hydrogen	NN
cord-300872-blycbi4u	544	26	gas	gas	NN
cord-300872-blycbi4u	544	27	in	in	IN
cord-300872-blycbi4u	544	28	the	the	DT
cord-300872-blycbi4u	544	29	presence	presence	NN
cord-300872-blycbi4u	544	30	of	of	IN
cord-300872-blycbi4u	544	31	the	the	DT
cord-300872-blycbi4u	544	32	palladium	palladium	NN
cord-300872-blycbi4u	544	33	catalyst	catalyst	NN
cord-300872-blycbi4u	544	34	yielded	yield	VBD
cord-300872-blycbi4u	544	35	the	the	DT
cord-300872-blycbi4u	544	36	desired	desire	VBN
cord-300872-blycbi4u	544	37	product	product	NN
cord-300872-blycbi4u	544	38	84	84	CD
cord-300872-blycbi4u	544	39	.	.	.
cord-300872-blycbi4u	545	1	On	on	IN
cord-300872-blycbi4u	545	2	the	the	DT
cord-300872-blycbi4u	545	3	other	other	JJ
cord-300872-blycbi4u	545	4	hand	hand	NN
cord-300872-blycbi4u	545	5	,	,	,
cord-300872-blycbi4u	545	6	synthesis	synthesis	NN
cord-300872-blycbi4u	545	7	of	of	IN
cord-300872-blycbi4u	545	8	compound	compound	NN
cord-300872-blycbi4u	545	9	87	87	CD
cord-300872-blycbi4u	545	10	was	be	VBD
cord-300872-blycbi4u	545	11	achieved	achieve	VBN
cord-300872-blycbi4u	545	12	by	by	IN
cord-300872-blycbi4u	545	13	converting	convert	VBG
cord-300872-blycbi4u	545	14	1	1	CD
cord-300872-blycbi4u	545	15	into	into	IN
cord-300872-blycbi4u	545	16	tert	tert	NNP
cord-300872-blycbi4u	545	17	-	-	HYPH
cord-300872-blycbi4u	545	18	butyldimethylsilyl	butyldimethylsilyl	NNP
cord-300872-blycbi4u	545	19	(	(	-LRB-
cord-300872-blycbi4u	545	20	TBS)-protected	tbs)-protecte	VBN
cord-300872-blycbi4u	545	21	2-aminoquinolin-8-ol	2-aminoquinolin-8-ol	CD
cord-300872-blycbi4u	545	22	(	(	-LRB-
cord-300872-blycbi4u	545	23	85	85	CD
cord-300872-blycbi4u	545	24	)	)	-RRB-
cord-300872-blycbi4u	545	25	.	.	.
cord-300872-blycbi4u	546	1	This	this	DT
cord-300872-blycbi4u	546	2	process	process	NN
cord-300872-blycbi4u	546	3	was	be	VBD
cord-300872-blycbi4u	546	4	carried	carry	VBN
cord-300872-blycbi4u	546	5	out	out	RP
cord-300872-blycbi4u	546	6	by	by	IN
cord-300872-blycbi4u	546	7	oxidation	oxidation	NN
cord-300872-blycbi4u	546	8	of	of	IN
cord-300872-blycbi4u	546	9	the	the	DT
cord-300872-blycbi4u	546	10	starting	starting	NN
cord-300872-blycbi4u	546	11	material	material	NN
cord-300872-blycbi4u	546	12	using	use	VBG
cord-300872-blycbi4u	546	13	m	m	NNP
cord-300872-blycbi4u	546	14	-	-	HYPH
cord-300872-blycbi4u	546	15	chloroperbenzoic	chloroperbenzoic	NNP
cord-300872-blycbi4u	546	16	acid	acid	NNP
cord-300872-blycbi4u	546	17	(	(	-LRB-
cord-300872-blycbi4u	546	18	mCPBA	mCPBA	NNP
cord-300872-blycbi4u	546	19	)	)	-RRB-
cord-300872-blycbi4u	546	20	to	to	TO
cord-300872-blycbi4u	546	21	form	form	VB
cord-300872-blycbi4u	546	22	N	n	CD
cord-300872-blycbi4u	546	23	-	-	HYPH
cord-300872-blycbi4u	546	24	oxide	oxide	NN
cord-300872-blycbi4u	546	25	,	,	,
cord-300872-blycbi4u	546	26	which	which	WDT
cord-300872-blycbi4u	546	27	was	be	VBD
cord-300872-blycbi4u	546	28	subsequently	subsequently	RB
cord-300872-blycbi4u	546	29	followed	follow	VBN
cord-300872-blycbi4u	546	30	by	by	IN
cord-300872-blycbi4u	546	31	refluxing	refluxe	VBG
cord-300872-blycbi4u	546	32	with	with	IN
cord-300872-blycbi4u	546	33	dimethylsulfate	dimethylsulfate	NN
cord-300872-blycbi4u	546	34	,	,	,
cord-300872-blycbi4u	546	35	treatment	treatment	NN
cord-300872-blycbi4u	546	36	with	with	IN
cord-300872-blycbi4u	546	37	NH4OH	NH4OH	NNP
cord-300872-blycbi4u	546	38	,	,	,
cord-300872-blycbi4u	546	39	and	and	CC
cord-300872-blycbi4u	546	40	finally	finally	RB
cord-300872-blycbi4u	546	41	protection	protection	NN
cord-300872-blycbi4u	546	42	with	with	IN
cord-300872-blycbi4u	546	43	tert	tert	NNP
cord-300872-blycbi4u	546	44	-	-	HYPH
cord-300872-blycbi4u	546	45	butyldimethylsilyl	butyldimethylsilyl	NNP
cord-300872-blycbi4u	546	46	chloride	chloride	NN
cord-300872-blycbi4u	546	47	(	(	-LRB-
cord-300872-blycbi4u	546	48	TBSCl	TBSCl	NNP
cord-300872-blycbi4u	546	49	)	)	-RRB-
cord-300872-blycbi4u	546	50	.	.	.
cord-300872-blycbi4u	547	1	The	the	DT
cord-300872-blycbi4u	547	2	obtained	obtain	VBN
cord-300872-blycbi4u	547	3	derivative	derivative	JJ
cord-300872-blycbi4u	547	4	86	86	CD
cord-300872-blycbi4u	547	5	was	be	VBD
cord-300872-blycbi4u	547	6	treated	treat	VBN
cord-300872-blycbi4u	547	7	with	with	IN
cord-300872-blycbi4u	547	8	the	the	DT
cord-300872-blycbi4u	547	9	corresponding	correspond	VBG
cord-300872-blycbi4u	547	10	benzoyl	benzoyl	NN
cord-300872-blycbi4u	547	11	chlorides	chloride	NNS
cord-300872-blycbi4u	547	12	,	,	,
cord-300872-blycbi4u	547	13	then	then	RB
cord-300872-blycbi4u	547	14	went	go	VBD
cord-300872-blycbi4u	547	15	through	through	IN
cord-300872-blycbi4u	547	16	the	the	DT
cord-300872-blycbi4u	547	17	deprotection	deprotection	NN
cord-300872-blycbi4u	547	18	process	process	NN
cord-300872-blycbi4u	547	19	using	use	VBG
cord-300872-blycbi4u	547	20	tetrabutylammoniumfluoride	tetrabutylammoniumfluoride	NNP
cord-300872-blycbi4u	547	21	(	(	-LRB-
cord-300872-blycbi4u	547	22	TBAF	TBAF	NNP
cord-300872-blycbi4u	547	23	)	)	-RRB-
cord-300872-blycbi4u	547	24	to	to	TO
cord-300872-blycbi4u	547	25	afford	afford	VB
cord-300872-blycbi4u	547	26	the	the	DT
cord-300872-blycbi4u	547	27	phenolic	phenolic	JJ
cord-300872-blycbi4u	547	28	group	group	NN
cord-300872-blycbi4u	547	29	in	in	IN
cord-300872-blycbi4u	547	30	the	the	DT
cord-300872-blycbi4u	547	31	target	target	NN
cord-300872-blycbi4u	547	32	derivative	derivative	JJ
cord-300872-blycbi4u	547	33	87	87	CD
cord-300872-blycbi4u	548	1	(	(	-LRB-
cord-300872-blycbi4u	548	2	Scheme	scheme	NN
cord-300872-blycbi4u	548	3	21	21	CD
cord-300872-blycbi4u	548	4	)	)	-RRB-
cord-300872-blycbi4u	548	5	.	.	.
cord-300872-blycbi4u	549	1	Compounds	compound	NNS
cord-300872-blycbi4u	549	2	79	79	CD
cord-300872-blycbi4u	549	3	,	,	,
cord-300872-blycbi4u	549	4	84	84	CD
cord-300872-blycbi4u	549	5	,	,	,
cord-300872-blycbi4u	549	6	and	and	CC
cord-300872-blycbi4u	549	7	87	87	CD
cord-300872-blycbi4u	549	8	are	be	VBP
cord-300872-blycbi4u	549	9	considered	consider	VBN
cord-300872-blycbi4u	549	10	hybrids	hybrid	NNS
cord-300872-blycbi4u	549	11	of	of	IN
cord-300872-blycbi4u	549	12	clioquinol	clioquinol	NN
cord-300872-blycbi4u	549	13	-	-	HYPH
cord-300872-blycbi4u	549	14	rolipram	rolipram	NNP
cord-300872-blycbi4u	549	15	and	and	CC
cord-300872-blycbi4u	549	16	roflumilast	roflumilast	JJ
cord-300872-blycbi4u	549	17	as	as	IN
cord-300872-blycbi4u	549	18	multitarget	multitarget	NN
cord-300872-blycbi4u	549	19	-	-	HYPH
cord-300872-blycbi4u	549	20	directed	direct	VBN
cord-300872-blycbi4u	549	21	ligands	ligand	NNS
cord-300872-blycbi4u	549	22	for	for	IN
cord-300872-blycbi4u	549	23	the	the	DT
cord-300872-blycbi4u	549	24	treatment	treatment	NN
cord-300872-blycbi4u	549	25	of	of	IN
cord-300872-blycbi4u	549	26	AD	ad	NN
cord-300872-blycbi4u	549	27	in	in	IN
cord-300872-blycbi4u	549	28	terms	term	NNS
cord-300872-blycbi4u	549	29	of	of	IN
cord-300872-blycbi4u	549	30	inhibition	inhibition	NN
cord-300872-blycbi4u	549	31	of	of	IN
cord-300872-blycbi4u	549	32	phosphodiesterase	phosphodiesterase	NN
cord-300872-blycbi4u	549	33	4D	4d	CD
cord-300872-blycbi4u	549	34	(	(	-LRB-
cord-300872-blycbi4u	549	35	PDE4D	PDE4D	NNP
cord-300872-blycbi4u	549	36	)	)	-RRB-
cord-300872-blycbi4u	549	37	,	,	,
cord-300872-blycbi4u	549	38	the	the	DT
cord-300872-blycbi4u	549	39	oxygen	oxygen	NN
cord-300872-blycbi4u	549	40	radical	radical	JJ
cord-300872-blycbi4u	549	41	absorbance	absorbance	NN
cord-300872-blycbi4u	549	42	capacity	capacity	NN
cord-300872-blycbi4u	549	43	(	(	-LRB-
cord-300872-blycbi4u	549	44	ORAC	ORAC	NNP
cord-300872-blycbi4u	549	45	)	)	-RRB-
cord-300872-blycbi4u	549	46	value	value	NN
cord-300872-blycbi4u	549	47	,	,	,
cord-300872-blycbi4u	549	48	and	and	CC
cord-300872-blycbi4u	549	49	the	the	DT
cord-300872-blycbi4u	549	50	experimental	experimental	JJ
cord-300872-blycbi4u	549	51	potential	potential	NN
cord-300872-blycbi4u	549	52	of	of	IN
cord-300872-blycbi4u	549	53	the	the	DT
cord-300872-blycbi4u	549	54	blood	blood	NN
cord-300872-blycbi4u	549	55	-	-	HYPH
cord-300872-blycbi4u	549	56	brain	brain	NN
cord-300872-blycbi4u	549	57	barrier	barrier	NN
cord-300872-blycbi4u	549	58	(	(	-LRB-
cord-300872-blycbi4u	549	59	BBB	BBB	NNP
cord-300872-blycbi4u	549	60	)	)	-RRB-
cord-300872-blycbi4u	549	61	permeability	permeability	NN
cord-300872-blycbi4u	549	62	(	(	-LRB-
cord-300872-blycbi4u	549	63	Pe	Pe	NNP
cord-300872-blycbi4u	549	64	)	)	-RRB-
cord-300872-blycbi4u	549	65	of	of	IN
cord-300872-blycbi4u	549	66	the	the	DT
cord-300872-blycbi4u	549	67	selected	select	VBN
cord-300872-blycbi4u	549	68	compounds	compound	NNS
cord-300872-blycbi4u	549	69	using	use	VBG
cord-300872-blycbi4u	549	70	parallel	parallel	JJ
cord-300872-blycbi4u	549	71	artificial	artificial	JJ
cord-300872-blycbi4u	549	72	membrane	membrane	NN
cord-300872-blycbi4u	549	73	permeation	permeation	NN
cord-300872-blycbi4u	549	74	assay	assay	NN
cord-300872-blycbi4u	549	75	(	(	-LRB-
cord-300872-blycbi4u	549	76	PAMPA	PAMPA	NNP
cord-300872-blycbi4u	549	77	)	)	-RRB-
cord-300872-blycbi4u	549	78	.	.	.
cord-300872-blycbi4u	550	1	In	in	IN
cord-300872-blycbi4u	550	2	this	this	DT
cord-300872-blycbi4u	550	3	respect	respect	NN
cord-300872-blycbi4u	550	4	,	,	,
cord-300872-blycbi4u	550	5	PDE4D	PDE4D	NNP
cord-300872-blycbi4u	550	6	is	be	VBZ
cord-300872-blycbi4u	550	7	involved	involve	VBN
cord-300872-blycbi4u	550	8	in	in	IN
cord-300872-blycbi4u	550	9	the	the	DT
cord-300872-blycbi4u	550	10	process	process	NN
cord-300872-blycbi4u	550	11	of	of	IN
cord-300872-blycbi4u	550	12	longterm	longterm	JJ
cord-300872-blycbi4u	550	13	potentiation	potentiation	NN
cord-300872-blycbi4u	550	14	and	and	CC
cord-300872-blycbi4u	550	15	memory	memory	NN
cord-300872-blycbi4u	550	16	consolidation	consolidation	NN
cord-300872-blycbi4u	550	17	.	.	.
cord-300872-blycbi4u	551	1	One	one	CD
cord-300872-blycbi4u	551	2	of	of	IN
cord-300872-blycbi4u	551	3	the	the	DT
cord-300872-blycbi4u	551	4	derivatives	derivative	NNS
cord-300872-blycbi4u	551	5	of	of	IN
cord-300872-blycbi4u	551	6	79	79	CD
cord-300872-blycbi4u	551	7	,	,	,
cord-300872-blycbi4u	551	8	for	for	IN
cord-300872-blycbi4u	551	9	which	which	WDT
cord-300872-blycbi4u	551	10	X	x	NN
cord-300872-blycbi4u	551	11	=	=	NN
cord-300872-blycbi4u	551	12	H	h	NN
cord-300872-blycbi4u	551	13	,	,	,
cord-300872-blycbi4u	551	14	R	r	NN
cord-300872-blycbi4u	551	15	1	1	CD
cord-300872-blycbi4u	552	1	=	=	SYM
cord-300872-blycbi4u	552	2	CF2H	CF2H	NNP
cord-300872-blycbi4u	552	3	,	,	,
cord-300872-blycbi4u	552	4	[	[	-LRB-
cord-300872-blycbi4u	552	5	57	57	CD
cord-300872-blycbi4u	552	6	]	]	-RRB-
cord-300872-blycbi4u	552	7	.	.	.
cord-300872-blycbi4u	553	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	553	2	of	of	IN
cord-300872-blycbi4u	553	3	these	these	DT
cord-300872-blycbi4u	553	4	compounds	compound	NNS
cord-300872-blycbi4u	553	5	involved	involve	VBD
cord-300872-blycbi4u	553	6	protection	protection	NN
cord-300872-blycbi4u	553	7	of	of	IN
cord-300872-blycbi4u	553	8	the	the	DT
cord-300872-blycbi4u	553	9	phenolic	phenolic	JJ
cord-300872-blycbi4u	553	10	group	group	NN
cord-300872-blycbi4u	553	11	in	in	IN
cord-300872-blycbi4u	553	12	76	76	CD
cord-300872-blycbi4u	553	13	using	use	VBG
cord-300872-blycbi4u	553	14	Boc	Boc	NNP
cord-300872-blycbi4u	553	15	group	group	NN
cord-300872-blycbi4u	553	16	to	to	TO
cord-300872-blycbi4u	553	17	allow	allow	VB
cord-300872-blycbi4u	553	18	the	the	DT
cord-300872-blycbi4u	553	19	reaction	reaction	NN
cord-300872-blycbi4u	553	20	of	of	IN
cord-300872-blycbi4u	553	21	the	the	DT
cord-300872-blycbi4u	553	22	primary	primary	JJ
cord-300872-blycbi4u	553	23	aromatic	aromatic	JJ
cord-300872-blycbi4u	553	24	amine	amine	NN
cord-300872-blycbi4u	553	25	in	in	IN
cord-300872-blycbi4u	553	26	77	77	CD
cord-300872-blycbi4u	553	27	with	with	IN
cord-300872-blycbi4u	553	28	substituted	substitute	VBN
cord-300872-blycbi4u	553	29	benzoyl	benzoyl	JJ
cord-300872-blycbi4u	553	30	chlorides	chloride	NNS
cord-300872-blycbi4u	553	31	in	in	IN
cord-300872-blycbi4u	553	32	the	the	DT
cord-300872-blycbi4u	553	33	presence	presence	NN
cord-300872-blycbi4u	553	34	of	of	IN
cord-300872-blycbi4u	553	35	triethylamine	triethylamine	NN
cord-300872-blycbi4u	553	36	(	(	-LRB-
cord-300872-blycbi4u	553	37	TEA	tea	NN
cord-300872-blycbi4u	553	38	)	)	-RRB-
cord-300872-blycbi4u	553	39	as	as	IN
cord-300872-blycbi4u	553	40	the	the	DT
cord-300872-blycbi4u	553	41	base	base	NN
cord-300872-blycbi4u	553	42	and	and	CC
cord-300872-blycbi4u	553	43	catalyst	catalyst	NN
cord-300872-blycbi4u	553	44	to	to	TO
cord-300872-blycbi4u	553	45	form	form	VB
cord-300872-blycbi4u	553	46	the	the	DT
cord-300872-blycbi4u	553	47	carboxamide	carboxamide	JJ
cord-300872-blycbi4u	553	48	group	group	NN
cord-300872-blycbi4u	553	49	78	78	CD
cord-300872-blycbi4u	553	50	.	.	.
cord-300872-blycbi4u	554	1	In	in	IN
cord-300872-blycbi4u	554	2	the	the	DT
cord-300872-blycbi4u	554	3	final	final	JJ
cord-300872-blycbi4u	554	4	step	step	NN
cord-300872-blycbi4u	554	5	,	,	,
cord-300872-blycbi4u	554	6	deprotection	deprotection	NN
cord-300872-blycbi4u	554	7	of	of	IN
cord-300872-blycbi4u	554	8	the	the	DT
cord-300872-blycbi4u	554	9	Boc	Boc	NNP
cord-300872-blycbi4u	554	10	group	group	NN
cord-300872-blycbi4u	554	11	was	be	VBD
cord-300872-blycbi4u	554	12	accomplished	accomplish	VBN
cord-300872-blycbi4u	554	13	with	with	IN
cord-300872-blycbi4u	554	14	hydrogen	hydrogen	NN
cord-300872-blycbi4u	554	15	chloride	chloride	NN
cord-300872-blycbi4u	554	16	to	to	TO
cord-300872-blycbi4u	554	17	afford	afford	VB
cord-300872-blycbi4u	554	18	the	the	DT
cord-300872-blycbi4u	554	19	desired	desire	VBN
cord-300872-blycbi4u	554	20	products	product	NNS
cord-300872-blycbi4u	554	21	as	as	IN
cord-300872-blycbi4u	554	22	salt	salt	NN
cord-300872-blycbi4u	554	23	79	79	CD
cord-300872-blycbi4u	554	24	.	.	.
cord-300872-blycbi4u	555	1	Regarding	regard	VBG
cord-300872-blycbi4u	555	2	Scheme	Scheme	NNP
cord-300872-blycbi4u	555	3	20	20	CD
cord-300872-blycbi4u	555	4	,	,	,
cord-300872-blycbi4u	555	5	the	the	DT
cord-300872-blycbi4u	555	6	phenoxide	phenoxide	JJ
cord-300872-blycbi4u	555	7	anion	anion	NN
cord-300872-blycbi4u	555	8	in	in	IN
cord-300872-blycbi4u	555	9	80	80	CD
cord-300872-blycbi4u	555	10	was	be	VBD
cord-300872-blycbi4u	555	11	formed	form	VBN
cord-300872-blycbi4u	555	12	in	in	IN
cord-300872-blycbi4u	555	13	situ	situ	NN
cord-300872-blycbi4u	555	14	by	by	IN
cord-300872-blycbi4u	555	15	reaction	reaction	NN
cord-300872-blycbi4u	555	16	of	of	IN
cord-300872-blycbi4u	555	17	the	the	DT
cord-300872-blycbi4u	555	18	phenolic	phenolic	JJ
cord-300872-blycbi4u	555	19	group	group	NN
cord-300872-blycbi4u	555	20	with	with	IN
cord-300872-blycbi4u	555	21	potassium	potassium	NN
cord-300872-blycbi4u	555	22	carbonate	carbonate	NN
cord-300872-blycbi4u	555	23	(	(	-LRB-
cord-300872-blycbi4u	555	24	base	base	NN
cord-300872-blycbi4u	555	25	)	)	-RRB-
cord-300872-blycbi4u	555	26	,	,	,
cord-300872-blycbi4u	555	27	which	which	WDT
cord-300872-blycbi4u	555	28	then	then	RB
cord-300872-blycbi4u	555	29	reacts	react	VBZ
cord-300872-blycbi4u	555	30	with	with	IN
cord-300872-blycbi4u	555	31	benzyl	benzyl	NN
cord-300872-blycbi4u	555	32	bromide	bromide	NN
cord-300872-blycbi4u	555	33	.	.	.
cord-300872-blycbi4u	556	1	The	the	DT
cord-300872-blycbi4u	556	2	methyl	methyl	NN
cord-300872-blycbi4u	556	3	group	group	NN
cord-300872-blycbi4u	556	4	in	in	IN
cord-300872-blycbi4u	556	5	81	81	CD
cord-300872-blycbi4u	556	6	was	be	VBD
cord-300872-blycbi4u	556	7	then	then	RB
cord-300872-blycbi4u	556	8	subjected	subject	VBN
cord-300872-blycbi4u	556	9	to	to	IN
cord-300872-blycbi4u	556	10	Pinnick	Pinnick	NNP
cord-300872-blycbi4u	556	11	oxidation	oxidation	NN
cord-300872-blycbi4u	556	12	using	use	VBG
cord-300872-blycbi4u	556	13	SeO	SeO	NNP
cord-300872-blycbi4u	556	14	2	2	CD
cord-300872-blycbi4u	556	15	to	to	TO
cord-300872-blycbi4u	556	16	afford	afford	VB
cord-300872-blycbi4u	556	17	the	the	DT
cord-300872-blycbi4u	556	18	corresponding	corresponding	JJ
cord-300872-blycbi4u	556	19	acid	acid	NN
cord-300872-blycbi4u	556	20	82	82	CD
cord-300872-blycbi4u	556	21	.	.	.
cord-300872-blycbi4u	557	1	Reaction	reaction	NN
cord-300872-blycbi4u	557	2	of	of	IN
cord-300872-blycbi4u	557	3	the	the	DT
cord-300872-blycbi4u	557	4	carboxylic	carboxylic	JJ
cord-300872-blycbi4u	557	5	acid	acid	NN
cord-300872-blycbi4u	557	6	group	group	NN
cord-300872-blycbi4u	557	7	in	in	IN
cord-300872-blycbi4u	557	8	82	82	CD
cord-300872-blycbi4u	557	9	with	with	IN
cord-300872-blycbi4u	557	10	thionyl	thionyl	NNP
cord-300872-blycbi4u	557	11	chloride	chloride	NN
cord-300872-blycbi4u	557	12	and	and	CC
cord-300872-blycbi4u	557	13	then	then	RB
cord-300872-blycbi4u	557	14	with	with	IN
cord-300872-blycbi4u	557	15	3-(cyclopentyloxy)-4-methoxyaniline	3-(cyclopentyloxy)-4-methoxyaniline	CD
cord-300872-blycbi4u	557	16	or	or	CC
cord-300872-blycbi4u	557	17	3,4-dimethoxyaniline	3,4-dimethoxyaniline	CD
cord-300872-blycbi4u	557	18	afforded	afford	VBN
cord-300872-blycbi4u	557	19	83	83	CD
cord-300872-blycbi4u	557	20	upon	upon	IN
cord-300872-blycbi4u	557	21	removal	removal	NN
cord-300872-blycbi4u	557	22	of	of	IN
cord-300872-blycbi4u	557	23	Bn	Bn	NNP
cord-300872-blycbi4u	557	24	with	with	IN
cord-300872-blycbi4u	557	25	hydrogen	hydrogen	NN
cord-300872-blycbi4u	557	26	gas	gas	NN
cord-300872-blycbi4u	557	27	in	in	IN
cord-300872-blycbi4u	557	28	the	the	DT
cord-300872-blycbi4u	557	29	presence	presence	NN
cord-300872-blycbi4u	557	30	of	of	IN
cord-300872-blycbi4u	557	31	the	the	DT
cord-300872-blycbi4u	557	32	palladium	palladium	NN
cord-300872-blycbi4u	557	33	catalyst	catalyst	NN
cord-300872-blycbi4u	557	34	yielded	yield	VBD
cord-300872-blycbi4u	557	35	the	the	DT
cord-300872-blycbi4u	557	36	desired	desire	VBN
cord-300872-blycbi4u	557	37	product	product	NN
cord-300872-blycbi4u	557	38	84	84	CD
cord-300872-blycbi4u	557	39	.	.	.
cord-300872-blycbi4u	558	1	On	on	IN
cord-300872-blycbi4u	558	2	the	the	DT
cord-300872-blycbi4u	558	3	other	other	JJ
cord-300872-blycbi4u	558	4	hand	hand	NN
cord-300872-blycbi4u	558	5	,	,	,
cord-300872-blycbi4u	558	6	synthesis	synthesis	NN
cord-300872-blycbi4u	558	7	of	of	IN
cord-300872-blycbi4u	558	8	compound	compound	NN
cord-300872-blycbi4u	558	9	87	87	CD
cord-300872-blycbi4u	558	10	was	be	VBD
cord-300872-blycbi4u	558	11	achieved	achieve	VBN
cord-300872-blycbi4u	558	12	by	by	IN
cord-300872-blycbi4u	558	13	converting	convert	VBG
cord-300872-blycbi4u	558	14	1	1	CD
cord-300872-blycbi4u	558	15	into	into	IN
cord-300872-blycbi4u	558	16	tert	tert	NNP
cord-300872-blycbi4u	558	17	-	-	HYPH
cord-300872-blycbi4u	558	18	butyldimethylsilyl	butyldimethylsilyl	NNP
cord-300872-blycbi4u	558	19	(	(	-LRB-
cord-300872-blycbi4u	558	20	TBS)-protected	tbs)-protecte	VBN
cord-300872-blycbi4u	558	21	2-aminoquinolin-8-ol	2-aminoquinolin-8-ol	CD
cord-300872-blycbi4u	558	22	(	(	-LRB-
cord-300872-blycbi4u	558	23	85	85	CD
cord-300872-blycbi4u	558	24	)	)	-RRB-
cord-300872-blycbi4u	558	25	.	.	.
cord-300872-blycbi4u	559	1	This	this	DT
cord-300872-blycbi4u	559	2	process	process	NN
cord-300872-blycbi4u	559	3	was	be	VBD
cord-300872-blycbi4u	559	4	carried	carry	VBN
cord-300872-blycbi4u	559	5	out	out	RP
cord-300872-blycbi4u	559	6	by	by	IN
cord-300872-blycbi4u	559	7	oxidation	oxidation	NN
cord-300872-blycbi4u	559	8	of	of	IN
cord-300872-blycbi4u	559	9	the	the	DT
cord-300872-blycbi4u	559	10	starting	starting	NN
cord-300872-blycbi4u	559	11	material	material	NN
cord-300872-blycbi4u	559	12	using	use	VBG
cord-300872-blycbi4u	559	13	m	m	NNP
cord-300872-blycbi4u	559	14	-	-	HYPH
cord-300872-blycbi4u	559	15	chloroperbenzoic	chloroperbenzoic	NNP
cord-300872-blycbi4u	559	16	acid	acid	NNP
cord-300872-blycbi4u	559	17	(	(	-LRB-
cord-300872-blycbi4u	559	18	mCPBA	mCPBA	NNP
cord-300872-blycbi4u	559	19	)	)	-RRB-
cord-300872-blycbi4u	559	20	to	to	TO
cord-300872-blycbi4u	559	21	form	form	VB
cord-300872-blycbi4u	559	22	N	n	CD
cord-300872-blycbi4u	559	23	-	-	HYPH
cord-300872-blycbi4u	559	24	oxide	oxide	NN
cord-300872-blycbi4u	559	25	,	,	,
cord-300872-blycbi4u	559	26	which	which	WDT
cord-300872-blycbi4u	559	27	was	be	VBD
cord-300872-blycbi4u	559	28	subsequently	subsequently	RB
cord-300872-blycbi4u	559	29	followed	follow	VBN
cord-300872-blycbi4u	559	30	by	by	IN
cord-300872-blycbi4u	559	31	refluxing	refluxe	VBG
cord-300872-blycbi4u	559	32	with	with	IN
cord-300872-blycbi4u	559	33	dimethylsulfate	dimethylsulfate	NN
cord-300872-blycbi4u	559	34	,	,	,
cord-300872-blycbi4u	559	35	treatment	treatment	NN
cord-300872-blycbi4u	559	36	with	with	IN
cord-300872-blycbi4u	559	37	NH	NH	NNP
cord-300872-blycbi4u	559	38	4	4	CD
cord-300872-blycbi4u	559	39	OH	oh	UH
cord-300872-blycbi4u	559	40	,	,	,
cord-300872-blycbi4u	559	41	and	and	CC
cord-300872-blycbi4u	559	42	finally	finally	RB
cord-300872-blycbi4u	559	43	protection	protection	NN
cord-300872-blycbi4u	559	44	with	with	IN
cord-300872-blycbi4u	559	45	tert	tert	NNP
cord-300872-blycbi4u	559	46	-	-	HYPH
cord-300872-blycbi4u	559	47	butyldimethylsilyl	butyldimethylsilyl	NNP
cord-300872-blycbi4u	559	48	chloride	chloride	NN
cord-300872-blycbi4u	559	49	(	(	-LRB-
cord-300872-blycbi4u	559	50	TBSCl	TBSCl	NNP
cord-300872-blycbi4u	559	51	)	)	-RRB-
cord-300872-blycbi4u	559	52	.	.	.
cord-300872-blycbi4u	560	1	The	the	DT
cord-300872-blycbi4u	560	2	obtained	obtain	VBN
cord-300872-blycbi4u	560	3	derivative	derivative	JJ
cord-300872-blycbi4u	560	4	86	86	CD
cord-300872-blycbi4u	560	5	was	be	VBD
cord-300872-blycbi4u	560	6	treated	treat	VBN
cord-300872-blycbi4u	560	7	with	with	IN
cord-300872-blycbi4u	560	8	the	the	DT
cord-300872-blycbi4u	560	9	corresponding	correspond	VBG
cord-300872-blycbi4u	560	10	benzoyl	benzoyl	NN
cord-300872-blycbi4u	560	11	chlorides	chloride	NNS
cord-300872-blycbi4u	560	12	,	,	,
cord-300872-blycbi4u	560	13	then	then	RB
cord-300872-blycbi4u	560	14	went	go	VBD
cord-300872-blycbi4u	560	15	through	through	IN
cord-300872-blycbi4u	560	16	the	the	DT
cord-300872-blycbi4u	560	17	deprotection	deprotection	NN
cord-300872-blycbi4u	560	18	process	process	NN
cord-300872-blycbi4u	560	19	using	use	VBG
cord-300872-blycbi4u	560	20	tetrabutylammoniumfluoride	tetrabutylammoniumfluoride	NNP
cord-300872-blycbi4u	560	21	(	(	-LRB-
cord-300872-blycbi4u	560	22	TBAF	TBAF	NNP
cord-300872-blycbi4u	560	23	)	)	-RRB-
cord-300872-blycbi4u	560	24	to	to	TO
cord-300872-blycbi4u	560	25	afford	afford	VB
cord-300872-blycbi4u	560	26	the	the	DT
cord-300872-blycbi4u	560	27	phenolic	phenolic	JJ
cord-300872-blycbi4u	560	28	group	group	NN
cord-300872-blycbi4u	560	29	in	in	IN
cord-300872-blycbi4u	560	30	the	the	DT
cord-300872-blycbi4u	560	31	target	target	NN
cord-300872-blycbi4u	560	32	derivative	derivative	JJ
cord-300872-blycbi4u	560	33	87	87	CD
cord-300872-blycbi4u	561	1	(	(	-LRB-
cord-300872-blycbi4u	561	2	Scheme	scheme	NN
cord-300872-blycbi4u	561	3	21	21	CD
cord-300872-blycbi4u	561	4	)	)	-RRB-
cord-300872-blycbi4u	561	5	.	.	.
cord-300872-blycbi4u	562	1	during	during	IN
cord-300872-blycbi4u	562	2	AD	ad	NN
cord-300872-blycbi4u	562	3	[	[	-LRB-
cord-300872-blycbi4u	562	4	60	60	CD
cord-300872-blycbi4u	562	5	]	]	-RRB-
cord-300872-blycbi4u	562	6	.	.	.
cord-300872-blycbi4u	563	1	The	the	DT
cord-300872-blycbi4u	563	2	Pe	Pe	NNP
cord-300872-blycbi4u	563	3	values	value	NNS
cord-300872-blycbi4u	563	4	of	of	IN
cord-300872-blycbi4u	563	5	selected	select	VBN
cord-300872-blycbi4u	563	6	compounds	compound	NNS
cord-300872-blycbi4u	563	7	were	be	VBD
cord-300872-blycbi4u	563	8	evaluated	evaluate	VBN
cord-300872-blycbi4u	563	9	using	use	VBG
cord-300872-blycbi4u	563	10	PAMPA	PAMPA	NNP
cord-300872-blycbi4u	563	11	.	.	.
cord-300872-blycbi4u	564	1	The	the	DT
cord-300872-blycbi4u	564	2	results	result	NNS
cord-300872-blycbi4u	564	3	indicated	indicate	VBD
cord-300872-blycbi4u	564	4	that	that	IN
cord-300872-blycbi4u	564	5	a	a	DT
cord-300872-blycbi4u	564	6	derivative	derivative	NN
cord-300872-blycbi4u	564	7	of	of	IN
cord-300872-blycbi4u	564	8	87	87	CD
cord-300872-blycbi4u	564	9	with	with	IN
cord-300872-blycbi4u	564	10	R	R	NNP
cord-300872-blycbi4u	564	11	1	1	CD
cord-300872-blycbi4u	564	12	=	=	SYM
cord-300872-blycbi4u	564	13	CH3	CH3	NNP
cord-300872-blycbi4u	564	14	and	and	CC
cord-300872-blycbi4u	564	15	R	R	NNP
cord-300872-blycbi4u	564	16	2	2	CD
cord-300872-blycbi4u	564	17	=	=	SYM
cord-300872-blycbi4u	564	18	cyclopentylmethyl	cyclopentylmethyl	NN
cord-300872-blycbi4u	564	19	exhibited	exhibit	VBD
cord-300872-blycbi4u	564	20	a	a	DT
cord-300872-blycbi4u	564	21	maximum	maximum	JJ
cord-300872-blycbi4u	564	22	value	value	NN
cord-300872-blycbi4u	564	23	of	of	IN
cord-300872-blycbi4u	564	24	Pe	Pe	NNP
cord-300872-blycbi4u	564	25	16.41	16.41	CD
cord-300872-blycbi4u	564	26	(	(	-LRB-
cord-300872-blycbi4u	564	27	±	±	CD
cord-300872-blycbi4u	564	28	0.44	0.44	CD
cord-300872-blycbi4u	564	29	)	)	-RRB-
cord-300872-blycbi4u	565	1	×	×	NNP
cord-300872-blycbi4u	565	2	10	10	CD
cord-300872-blycbi4u	565	3	6	6	CD
cord-300872-blycbi4u	565	4	cm	cm	NN
cord-300872-blycbi4u	565	5	s	s	NNP
cord-300872-blycbi4u	565	6	-1	-1	NN
cord-300872-blycbi4u	565	7	,	,	,
cord-300872-blycbi4u	565	8	whereas	whereas	IN
cord-300872-blycbi4u	565	9	other	other	JJ
cord-300872-blycbi4u	565	10	tested	test	VBN
cord-300872-blycbi4u	565	11	compounds	compound	NNS
cord-300872-blycbi4u	565	12	showed	show	VBD
cord-300872-blycbi4u	565	13	values	value	NNS
cord-300872-blycbi4u	565	14	higher	high	JJR
cord-300872-blycbi4u	565	15	than	than	IN
cord-300872-blycbi4u	565	16	4.7	4.7	CD
cord-300872-blycbi4u	565	17	×	×	NN
cord-300872-blycbi4u	565	18	10	10	CD
cord-300872-blycbi4u	565	19	6	6	CD
cord-300872-blycbi4u	565	20	cm	cm	NN
cord-300872-blycbi4u	565	21	s	s	NNP
cord-300872-blycbi4u	565	22	-1	-1	NN
cord-300872-blycbi4u	565	23	,	,	,
cord-300872-blycbi4u	565	24	indicating	indicate	VBG
cord-300872-blycbi4u	565	25	that	that	IN
cord-300872-blycbi4u	565	26	these	these	DT
cord-300872-blycbi4u	565	27	compounds	compound	NNS
cord-300872-blycbi4u	565	28	may	may	MD
cord-300872-blycbi4u	565	29	cross	cross	VB
cord-300872-blycbi4u	565	30	the	the	DT
cord-300872-blycbi4u	565	31	BBB	BBB	NNP
cord-300872-blycbi4u	565	32	.	.	.
cord-300872-blycbi4u	566	1	The	the	DT
cord-300872-blycbi4u	566	2	Pe	Pe	NNP
cord-300872-blycbi4u	566	3	values	value	NNS
cord-300872-blycbi4u	566	4	for	for	IN
cord-300872-blycbi4u	566	5	rolipram	rolipram	NNP
cord-300872-blycbi4u	566	6	,	,	,
cord-300872-blycbi4u	566	7	roflumilast	roflumilast	NNP
cord-300872-blycbi4u	566	8	,	,	,
cord-300872-blycbi4u	566	9	and	and	CC
cord-300872-blycbi4u	566	10	clioquinol	clioquinol	NN
cord-300872-blycbi4u	566	11	were	be	VBD
cord-300872-blycbi4u	566	12	evaluated	evaluate	VBN
cord-300872-blycbi4u	566	13	as	as	IN
cord-300872-blycbi4u	566	14	(	(	-LRB-
cord-300872-blycbi4u	566	15	18.87	18.87	CD
cord-300872-blycbi4u	566	16	±	±	CD
cord-300872-blycbi4u	566	17	0.57	0.57	CD
cord-300872-blycbi4u	566	18	)	)	-RRB-
cord-300872-blycbi4u	566	19	,	,	,
cord-300872-blycbi4u	566	20	(	(	-LRB-
cord-300872-blycbi4u	566	21	9.22	9.22	CD
cord-300872-blycbi4u	566	22	±	±	CD
cord-300872-blycbi4u	566	23	0.62	0.62	CD
cord-300872-blycbi4u	566	24	)	)	-RRB-
cord-300872-blycbi4u	566	25	,	,	,
cord-300872-blycbi4u	566	26	and	and	CC
cord-300872-blycbi4u	567	1	(	(	-LRB-
cord-300872-blycbi4u	567	2	5.20	5.20	CD
cord-300872-blycbi4u	567	3	±	±	CD
cord-300872-blycbi4u	567	4	0.33	0.33	CD
cord-300872-blycbi4u	567	5	)	)	-RRB-
cord-300872-blycbi4u	568	1	x	x	SYM
cord-300872-blycbi4u	568	2	10	10	CD
cord-300872-blycbi4u	568	3	6	6	CD
cord-300872-blycbi4u	568	4	cm	cm	NN
cord-300872-blycbi4u	568	5	s	s	NN
cord-300872-blycbi4u	568	6	-1	-1	NN
cord-300872-blycbi4u	568	7	,	,	,
cord-300872-blycbi4u	568	8	respectively	respectively	RB
cord-300872-blycbi4u	568	9	.	.	.
cord-300872-blycbi4u	569	1	during	during	IN
cord-300872-blycbi4u	569	2	AD	ad	NN
cord-300872-blycbi4u	569	3	[	[	-LRB-
cord-300872-blycbi4u	569	4	60	60	CD
cord-300872-blycbi4u	569	5	]	]	-RRB-
cord-300872-blycbi4u	569	6	.	.	.
cord-300872-blycbi4u	570	1	The	the	DT
cord-300872-blycbi4u	570	2	Pe	Pe	NNP
cord-300872-blycbi4u	570	3	values	value	NNS
cord-300872-blycbi4u	570	4	of	of	IN
cord-300872-blycbi4u	570	5	selected	select	VBN
cord-300872-blycbi4u	570	6	compounds	compound	NNS
cord-300872-blycbi4u	570	7	were	be	VBD
cord-300872-blycbi4u	570	8	evaluated	evaluate	VBN
cord-300872-blycbi4u	570	9	using	use	VBG
cord-300872-blycbi4u	570	10	PAMPA	PAMPA	NNP
cord-300872-blycbi4u	570	11	.	.	.
cord-300872-blycbi4u	571	1	The	the	DT
cord-300872-blycbi4u	571	2	results	result	NNS
cord-300872-blycbi4u	571	3	indicated	indicate	VBD
cord-300872-blycbi4u	571	4	that	that	IN
cord-300872-blycbi4u	571	5	a	a	DT
cord-300872-blycbi4u	571	6	derivative	derivative	NN
cord-300872-blycbi4u	571	7	of	of	IN
cord-300872-blycbi4u	571	8	87	87	CD
cord-300872-blycbi4u	571	9	with	with	IN
cord-300872-blycbi4u	571	10	R	R	NNP
cord-300872-blycbi4u	571	11	1	1	CD
cord-300872-blycbi4u	571	12	=	=	SYM
cord-300872-blycbi4u	571	13	CH3	CH3	NNP
cord-300872-blycbi4u	571	14	and	and	CC
cord-300872-blycbi4u	571	15	R	R	NNP
cord-300872-blycbi4u	571	16	2	2	CD
cord-300872-blycbi4u	571	17	=	=	SYM
cord-300872-blycbi4u	571	18	cyclopentylmethyl	cyclopentylmethyl	NN
cord-300872-blycbi4u	571	19	exhibited	exhibit	VBD
cord-300872-blycbi4u	571	20	a	a	DT
cord-300872-blycbi4u	571	21	maximum	maximum	JJ
cord-300872-blycbi4u	571	22	value	value	NN
cord-300872-blycbi4u	571	23	of	of	IN
cord-300872-blycbi4u	571	24	Pe	Pe	NNP
cord-300872-blycbi4u	571	25	16.41	16.41	CD
cord-300872-blycbi4u	571	26	(	(	-LRB-
cord-300872-blycbi4u	571	27	±	±	CD
cord-300872-blycbi4u	571	28	0.44	0.44	CD
cord-300872-blycbi4u	571	29	)	)	-RRB-
cord-300872-blycbi4u	572	1	×	×	NNP
cord-300872-blycbi4u	572	2	10	10	CD
cord-300872-blycbi4u	572	3	6	6	CD
cord-300872-blycbi4u	572	4	cm	cm	NN
cord-300872-blycbi4u	572	5	s	s	NNP
cord-300872-blycbi4u	572	6	-1	-1	NN
cord-300872-blycbi4u	572	7	,	,	,
cord-300872-blycbi4u	572	8	whereas	whereas	IN
cord-300872-blycbi4u	572	9	other	other	JJ
cord-300872-blycbi4u	572	10	tested	test	VBN
cord-300872-blycbi4u	572	11	compounds	compound	NNS
cord-300872-blycbi4u	572	12	showed	show	VBD
cord-300872-blycbi4u	572	13	values	value	NNS
cord-300872-blycbi4u	572	14	higher	high	JJR
cord-300872-blycbi4u	572	15	than	than	IN
cord-300872-blycbi4u	572	16	4.7	4.7	CD
cord-300872-blycbi4u	572	17	×	×	NN
cord-300872-blycbi4u	572	18	10	10	CD
cord-300872-blycbi4u	572	19	6	6	CD
cord-300872-blycbi4u	572	20	cm	cm	NN
cord-300872-blycbi4u	572	21	s	s	NNP
cord-300872-blycbi4u	572	22	-1	-1	NN
cord-300872-blycbi4u	572	23	,	,	,
cord-300872-blycbi4u	572	24	indicating	indicate	VBG
cord-300872-blycbi4u	572	25	that	that	IN
cord-300872-blycbi4u	572	26	these	these	DT
cord-300872-blycbi4u	572	27	compounds	compound	NNS
cord-300872-blycbi4u	572	28	may	may	MD
cord-300872-blycbi4u	572	29	cross	cross	VB
cord-300872-blycbi4u	572	30	the	the	DT
cord-300872-blycbi4u	572	31	BBB	BBB	NNP
cord-300872-blycbi4u	572	32	.	.	.
cord-300872-blycbi4u	573	1	The	the	DT
cord-300872-blycbi4u	573	2	Pe	Pe	NNP
cord-300872-blycbi4u	573	3	values	value	NNS
cord-300872-blycbi4u	573	4	for	for	IN
cord-300872-blycbi4u	573	5	rolipram	rolipram	NNP
cord-300872-blycbi4u	573	6	,	,	,
cord-300872-blycbi4u	573	7	roflumilast	roflumilast	NNP
cord-300872-blycbi4u	573	8	,	,	,
cord-300872-blycbi4u	573	9	and	and	CC
cord-300872-blycbi4u	573	10	clioquinol	clioquinol	NN
cord-300872-blycbi4u	573	11	were	be	VBD
cord-300872-blycbi4u	573	12	evaluated	evaluate	VBN
cord-300872-blycbi4u	573	13	as	as	IN
cord-300872-blycbi4u	573	14	(	(	-LRB-
cord-300872-blycbi4u	573	15	18.87	18.87	CD
cord-300872-blycbi4u	573	16	±	±	CD
cord-300872-blycbi4u	573	17	0.57	0.57	CD
cord-300872-blycbi4u	573	18	)	)	-RRB-
cord-300872-blycbi4u	573	19	,	,	,
cord-300872-blycbi4u	573	20	(	(	-LRB-
cord-300872-blycbi4u	573	21	9.22	9.22	CD
cord-300872-blycbi4u	573	22	±	±	CD
cord-300872-blycbi4u	573	23	0.62	0.62	CD
cord-300872-blycbi4u	573	24	)	)	-RRB-
cord-300872-blycbi4u	573	25	,	,	,
cord-300872-blycbi4u	573	26	and	and	CC
cord-300872-blycbi4u	574	1	(	(	-LRB-
cord-300872-blycbi4u	574	2	5.20	5.20	CD
cord-300872-blycbi4u	574	3	±	±	CD
cord-300872-blycbi4u	574	4	0.33	0.33	CD
cord-300872-blycbi4u	574	5	)	)	-RRB-
cord-300872-blycbi4u	575	1	x	x	SYM
cord-300872-blycbi4u	575	2	10	10	CD
cord-300872-blycbi4u	575	3	6	6	CD
cord-300872-blycbi4u	575	4	cm	cm	NN
cord-300872-blycbi4u	575	5	s	s	NN
cord-300872-blycbi4u	575	6	-1	-1	NN
cord-300872-blycbi4u	575	7	,	,	,
cord-300872-blycbi4u	575	8	respectively	respectively	RB
cord-300872-blycbi4u	575	9	.	.	.
cord-300872-blycbi4u	576	1	Figure	figure	NN
cord-300872-blycbi4u	576	2	6	6	CD
cord-300872-blycbi4u	576	3	[	[	-LRB-
cord-300872-blycbi4u	576	4	61	61	CD
cord-300872-blycbi4u	576	5	]	]	-RRB-
cord-300872-blycbi4u	576	6	.	.	.
cord-300872-blycbi4u	577	1	Compounds	compound	NNS
cord-300872-blycbi4u	577	2	88	88	CD
cord-300872-blycbi4u	577	3	and	and	CC
cord-300872-blycbi4u	577	4	89	89	CD
cord-300872-blycbi4u	577	5	were	be	VBD
cord-300872-blycbi4u	577	6	prepared	prepare	VBN
cord-300872-blycbi4u	577	7	from	from	IN
cord-300872-blycbi4u	577	8	8-HQ	8-hq	CD
cord-300872-blycbi4u	577	9	by	by	IN
cord-300872-blycbi4u	577	10	reaction	reaction	NN
cord-300872-blycbi4u	577	11	first	first	RB
cord-300872-blycbi4u	577	12	with	with	IN
cord-300872-blycbi4u	577	13	formaldehyde	formaldehyde	NN
cord-300872-blycbi4u	577	14	in	in	IN
cord-300872-blycbi4u	577	15	the	the	DT
cord-300872-blycbi4u	577	16	presence	presence	NN
cord-300872-blycbi4u	577	17	of	of	IN
cord-300872-blycbi4u	577	18	hydrogen	hydrogen	NN
cord-300872-blycbi4u	577	19	chloride	chloride	NN
cord-300872-blycbi4u	577	20	,	,	,
cord-300872-blycbi4u	577	21	followed	follow	VBN
cord-300872-blycbi4u	577	22	by	by	IN
cord-300872-blycbi4u	577	23	reaction	reaction	NN
cord-300872-blycbi4u	577	24	with	with	IN
cord-300872-blycbi4u	577	25	triethylphosphite	triethylphosphite	NNP
cord-300872-blycbi4u	577	26	to	to	TO
cord-300872-blycbi4u	577	27	afford	afford	VB
cord-300872-blycbi4u	577	28	diethyl	diethyl	FW
cord-300872-blycbi4u	577	29	(	(	-LRB-
cord-300872-blycbi4u	577	30	(	(	-LRB-
cord-300872-blycbi4u	577	31	8-hydroxyquinolin-5-yl)methyl)phosphonate	8-hydroxyquinolin-5-yl)methyl)phosphonate	CD
cord-300872-blycbi4u	577	32	[	[	-LRB-
cord-300872-blycbi4u	577	33	56	56	CD
cord-300872-blycbi4u	577	34	]	]	-RRB-
cord-300872-blycbi4u	577	35	.	.	.
cord-300872-blycbi4u	578	1	In	in	IN
cord-300872-blycbi4u	578	2	this	this	DT
cord-300872-blycbi4u	578	3	reaction	reaction	NN
cord-300872-blycbi4u	578	4	,	,	,
cord-300872-blycbi4u	578	5	the	the	DT
cord-300872-blycbi4u	578	6	phenolic	phenolic	JJ
cord-300872-blycbi4u	578	7	group	group	NN
cord-300872-blycbi4u	578	8	was	be	VBD
cord-300872-blycbi4u	578	9	protected	protect	VBN
cord-300872-blycbi4u	578	10	via	via	IN
cord-300872-blycbi4u	578	11	reaction	reaction	NN
cord-300872-blycbi4u	578	12	with	with	IN
cord-300872-blycbi4u	578	13	chloro(methoxy)methane	chloro(methoxy)methane	NN
cord-300872-blycbi4u	578	14	to	to	TO
cord-300872-blycbi4u	578	15	yield	yield	VB
cord-300872-blycbi4u	578	16	diethyl	diethyl	FW
cord-300872-blycbi4u	578	17	(	(	-LRB-
cord-300872-blycbi4u	578	18	(	(	-LRB-
cord-300872-blycbi4u	578	19	8-(methoxymethoxy)quinolin-5-yl)methyl)-phosphonate	8-(methoxymethoxy)quinolin-5-yl)methyl)-phosphonate	CD
cord-300872-blycbi4u	578	20	.	.	.
cord-300872-blycbi4u	579	1	Subsequent	subsequent	JJ
cord-300872-blycbi4u	579	2	reaction	reaction	NN
cord-300872-blycbi4u	579	3	of	of	IN
cord-300872-blycbi4u	579	4	the	the	DT
cord-300872-blycbi4u	579	5	last	last	JJ
cord-300872-blycbi4u	579	6	compound	compound	NN
cord-300872-blycbi4u	579	7	with	with	IN
cord-300872-blycbi4u	579	8	various	various	JJ
cord-300872-blycbi4u	579	9	2-nitrobenzaldehydes	2-nitrobenzaldehydes	CD
cord-300872-blycbi4u	579	10	in	in	IN
cord-300872-blycbi4u	579	11	the	the	DT
cord-300872-blycbi4u	579	12	presence	presence	NN
cord-300872-blycbi4u	579	13	of	of	IN
cord-300872-blycbi4u	579	14	sodium	sodium	NN
cord-300872-blycbi4u	579	15	hydride	hydride	NN
cord-300872-blycbi4u	579	16	yielded	yield	VBD
cord-300872-blycbi4u	579	17	derivatives	derivative	NNS
cord-300872-blycbi4u	579	18	of	of	IN
cord-300872-blycbi4u	579	19	8-(methoxymethoxy)-5-(2-nitrostyryl)quinolone	8-(methoxymethoxy)-5-(2-nitrostyryl)quinolone	CD
cord-300872-blycbi4u	579	20	.	.	.
cord-300872-blycbi4u	580	1	Reductive	reductive	JJ
cord-300872-blycbi4u	580	2	cyclization	cyclization	NN
cord-300872-blycbi4u	580	3	of	of	IN
cord-300872-blycbi4u	580	4	2-nitrostyrenes	2-nitrostyrenes	CD
cord-300872-blycbi4u	580	5	with	with	IN
cord-300872-blycbi4u	580	6	carbon	carbon	NN
cord-300872-blycbi4u	580	7	monoxide	monoxide	NN
cord-300872-blycbi4u	580	8	followed	follow	VBN
cord-300872-blycbi4u	580	9	by	by	IN
cord-300872-blycbi4u	580	10	removal	removal	NN
cord-300872-blycbi4u	580	11	of	of	IN
cord-300872-blycbi4u	580	12	the	the	DT
cord-300872-blycbi4u	580	13	protecting	protect	VBG
cord-300872-blycbi4u	580	14	group	group	NN
cord-300872-blycbi4u	580	15	(	(	-LRB-
cord-300872-blycbi4u	580	16	methoxymethane	methoxymethane	NNP
cord-300872-blycbi4u	580	17	)	)	-RRB-
cord-300872-blycbi4u	580	18	by	by	IN
cord-300872-blycbi4u	580	19	hydrochloride	hydrochloride	NN
cord-300872-blycbi4u	580	20	solution	solution	NN
cord-300872-blycbi4u	580	21	led	lead	VBD
cord-300872-blycbi4u	580	22	to	to	IN
cord-300872-blycbi4u	580	23	the	the	DT
cord-300872-blycbi4u	580	24	formation	formation	NN
cord-300872-blycbi4u	580	25	of	of	IN
cord-300872-blycbi4u	580	26	the	the	DT
cord-300872-blycbi4u	580	27	final	final	JJ
cord-300872-blycbi4u	580	28	product	product	NN
cord-300872-blycbi4u	580	29	.	.	.
cord-300872-blycbi4u	581	1	For	for	IN
cord-300872-blycbi4u	581	2	compound	compound	NN
cord-300872-blycbi4u	581	3	89	89	CD
cord-300872-blycbi4u	581	4	,	,	,
cord-300872-blycbi4u	581	5	diethyl	diethyl	NNP
cord-300872-blycbi4u	581	6	(	(	-LRB-
cord-300872-blycbi4u	581	7	(	(	-LRB-
cord-300872-blycbi4u	581	8	7-chloro-8-	7-chloro-8-	CD
cord-300872-blycbi4u	581	9	Compounds	Compounds	NNPS
cord-300872-blycbi4u	581	10	79	79	CD
cord-300872-blycbi4u	581	11	,	,	,
cord-300872-blycbi4u	581	12	84	84	CD
cord-300872-blycbi4u	581	13	,	,	,
cord-300872-blycbi4u	581	14	and	and	CC
cord-300872-blycbi4u	581	15	87	87	CD
cord-300872-blycbi4u	581	16	are	be	VBP
cord-300872-blycbi4u	581	17	considered	consider	VBN
cord-300872-blycbi4u	581	18	hybrids	hybrid	NNS
cord-300872-blycbi4u	581	19	of	of	IN
cord-300872-blycbi4u	581	20	clioquinol	clioquinol	NN
cord-300872-blycbi4u	581	21	-	-	HYPH
cord-300872-blycbi4u	581	22	rolipram	rolipram	NNP
cord-300872-blycbi4u	581	23	and	and	CC
cord-300872-blycbi4u	581	24	roflumilast	roflumilast	JJ
cord-300872-blycbi4u	581	25	as	as	IN
cord-300872-blycbi4u	581	26	multitarget	multitarget	NN
cord-300872-blycbi4u	581	27	-	-	HYPH
cord-300872-blycbi4u	581	28	directed	direct	VBN
cord-300872-blycbi4u	581	29	ligands	ligand	NNS
cord-300872-blycbi4u	581	30	for	for	IN
cord-300872-blycbi4u	581	31	the	the	DT
cord-300872-blycbi4u	581	32	treatment	treatment	NN
cord-300872-blycbi4u	581	33	of	of	IN
cord-300872-blycbi4u	581	34	AD	ad	NN
cord-300872-blycbi4u	581	35	in	in	IN
cord-300872-blycbi4u	581	36	terms	term	NNS
cord-300872-blycbi4u	581	37	of	of	IN
cord-300872-blycbi4u	581	38	inhibition	inhibition	NN
cord-300872-blycbi4u	581	39	of	of	IN
cord-300872-blycbi4u	581	40	phosphodiesterase	phosphodiesterase	NN
cord-300872-blycbi4u	581	41	4D	4d	CD
cord-300872-blycbi4u	581	42	(	(	-LRB-
cord-300872-blycbi4u	581	43	PDE4D	PDE4D	NNP
cord-300872-blycbi4u	581	44	)	)	-RRB-
cord-300872-blycbi4u	581	45	,	,	,
cord-300872-blycbi4u	581	46	the	the	DT
cord-300872-blycbi4u	581	47	oxygen	oxygen	NN
cord-300872-blycbi4u	581	48	radical	radical	JJ
cord-300872-blycbi4u	581	49	absorbance	absorbance	NN
cord-300872-blycbi4u	581	50	capacity	capacity	NN
cord-300872-blycbi4u	581	51	(	(	-LRB-
cord-300872-blycbi4u	581	52	ORAC	ORAC	NNP
cord-300872-blycbi4u	581	53	)	)	-RRB-
cord-300872-blycbi4u	581	54	value	value	NN
cord-300872-blycbi4u	581	55	,	,	,
cord-300872-blycbi4u	581	56	and	and	CC
cord-300872-blycbi4u	581	57	the	the	DT
cord-300872-blycbi4u	581	58	experimental	experimental	JJ
cord-300872-blycbi4u	581	59	potential	potential	NN
cord-300872-blycbi4u	581	60	of	of	IN
cord-300872-blycbi4u	581	61	the	the	DT
cord-300872-blycbi4u	581	62	blood	blood	NN
cord-300872-blycbi4u	581	63	-	-	HYPH
cord-300872-blycbi4u	581	64	brain	brain	NN
cord-300872-blycbi4u	581	65	barrier	barrier	NN
cord-300872-blycbi4u	581	66	(	(	-LRB-
cord-300872-blycbi4u	581	67	BBB	BBB	NNP
cord-300872-blycbi4u	581	68	)	)	-RRB-
cord-300872-blycbi4u	581	69	permeability	permeability	NN
cord-300872-blycbi4u	581	70	(	(	-LRB-
cord-300872-blycbi4u	581	71	Pe	Pe	NNP
cord-300872-blycbi4u	581	72	)	)	-RRB-
cord-300872-blycbi4u	581	73	of	of	IN
cord-300872-blycbi4u	581	74	the	the	DT
cord-300872-blycbi4u	581	75	selected	select	VBN
cord-300872-blycbi4u	581	76	compounds	compound	NNS
cord-300872-blycbi4u	581	77	using	use	VBG
cord-300872-blycbi4u	581	78	parallel	parallel	JJ
cord-300872-blycbi4u	581	79	artificial	artificial	JJ
cord-300872-blycbi4u	581	80	membrane	membrane	NN
cord-300872-blycbi4u	581	81	permeation	permeation	NN
cord-300872-blycbi4u	581	82	assay	assay	NN
cord-300872-blycbi4u	581	83	(	(	-LRB-
cord-300872-blycbi4u	581	84	PAMPA	PAMPA	NNP
cord-300872-blycbi4u	581	85	)	)	-RRB-
cord-300872-blycbi4u	581	86	.	.	.
cord-300872-blycbi4u	582	1	In	in	IN
cord-300872-blycbi4u	582	2	this	this	DT
cord-300872-blycbi4u	582	3	respect	respect	NN
cord-300872-blycbi4u	582	4	,	,	,
cord-300872-blycbi4u	582	5	PDE4D	PDE4D	NNP
cord-300872-blycbi4u	582	6	is	be	VBZ
cord-300872-blycbi4u	582	7	involved	involve	VBN
cord-300872-blycbi4u	582	8	in	in	IN
cord-300872-blycbi4u	582	9	the	the	DT
cord-300872-blycbi4u	582	10	process	process	NN
cord-300872-blycbi4u	582	11	of	of	IN
cord-300872-blycbi4u	582	12	long	long	JJ
cord-300872-blycbi4u	582	13	-	-	HYPH
cord-300872-blycbi4u	582	14	term	term	NN
cord-300872-blycbi4u	582	15	potentiation	potentiation	NN
cord-300872-blycbi4u	582	16	and	and	CC
cord-300872-blycbi4u	582	17	memory	memory	NN
cord-300872-blycbi4u	582	18	consolidation	consolidation	NN
cord-300872-blycbi4u	582	19	.	.	.
cord-300872-blycbi4u	583	1	One	one	CD
cord-300872-blycbi4u	583	2	of	of	IN
cord-300872-blycbi4u	583	3	the	the	DT
cord-300872-blycbi4u	583	4	derivatives	derivative	NNS
cord-300872-blycbi4u	583	5	of	of	IN
cord-300872-blycbi4u	583	6	79	79	CD
cord-300872-blycbi4u	583	7	,	,	,
cord-300872-blycbi4u	583	8	for	for	IN
cord-300872-blycbi4u	583	9	which	which	WDT
cord-300872-blycbi4u	583	10	X	x	NN
cord-300872-blycbi4u	583	11	=	=	NN
cord-300872-blycbi4u	583	12	H	h	NN
cord-300872-blycbi4u	583	13	,	,	,
cord-300872-blycbi4u	583	14	R	r	NN
cord-300872-blycbi4u	583	15	1	1	CD
cord-300872-blycbi4u	583	16	=	=	NN
cord-300872-blycbi4u	583	17	CF	cf	NN
cord-300872-blycbi4u	583	18	2	2	CD
cord-300872-blycbi4u	583	19	H	h	NN
cord-300872-blycbi4u	583	20	,	,	,
cord-300872-blycbi4u	583	21	R	r	NN
cord-300872-blycbi4u	583	22	2	2	CD
cord-300872-blycbi4u	583	23	=	=	SYM
cord-300872-blycbi4u	583	24	cyclopentylethyl	cyclopentylethyl	NN
cord-300872-blycbi4u	583	25	,	,	,
cord-300872-blycbi4u	583	26	exhibited	exhibit	VBD
cord-300872-blycbi4u	583	27	an	an	DT
cord-300872-blycbi4u	583	28	IC	IC	NNP
cord-300872-blycbi4u	583	29	50	50	CD
cord-300872-blycbi4u	583	30	of	of	IN
cord-300872-blycbi4u	583	31	0.399	0.399	CD
cord-300872-blycbi4u	583	32	mM	mm	CD
cord-300872-blycbi4u	583	33	against	against	IN
cord-300872-blycbi4u	583	34	PDE4D	PDE4D	NNS
cord-300872-blycbi4u	583	35	compared	compare	VBN
cord-300872-blycbi4u	583	36	to	to	IN
cord-300872-blycbi4u	583	37	rolipram	rolipram	NNP
cord-300872-blycbi4u	583	38	as	as	IN
cord-300872-blycbi4u	583	39	the	the	DT
cord-300872-blycbi4u	583	40	reference	reference	NN
cord-300872-blycbi4u	583	41	compound	compound	NN
cord-300872-blycbi4u	583	42	(	(	-LRB-
cord-300872-blycbi4u	583	43	IC	IC	NNP
cord-300872-blycbi4u	583	44	50	50	CD
cord-300872-blycbi4u	583	45	0.621	0.621	CD
cord-300872-blycbi4u	583	46	mM	mm	CD
cord-300872-blycbi4u	583	47	)	)	-RRB-
cord-300872-blycbi4u	583	48	,	,	,
cord-300872-blycbi4u	583	49	whereas	whereas	IN
cord-300872-blycbi4u	583	50	the	the	DT
cord-300872-blycbi4u	583	51	derivative	derivative	JJ
cord-300872-blycbi4u	583	52	showing	showing	NN
cord-300872-blycbi4u	583	53	X	x	NN
cord-300872-blycbi4u	583	54	=	=	NN
cord-300872-blycbi4u	583	55	H	h	NN
cord-300872-blycbi4u	583	56	,	,	,
cord-300872-blycbi4u	584	1	R	r	NN
cord-300872-blycbi4u	584	2	1	1	CD
cord-300872-blycbi4u	584	3	=	=	SYM
cord-300872-blycbi4u	584	4	cyclopentylmethyl	cyclopentylmethyl	NN
cord-300872-blycbi4u	584	5	of	of	IN
cord-300872-blycbi4u	584	6	family	family	NN
cord-300872-blycbi4u	584	7	84	84	CD
cord-300872-blycbi4u	584	8	exhibited	exhibit	VBD
cord-300872-blycbi4u	584	9	the	the	DT
cord-300872-blycbi4u	584	10	highest	high	JJS
cord-300872-blycbi4u	584	11	value	value	NN
cord-300872-blycbi4u	584	12	among	among	IN
cord-300872-blycbi4u	584	13	all	all	DT
cord-300872-blycbi4u	584	14	tested	test	VBN
cord-300872-blycbi4u	584	15	compounds	compound	NNS
cord-300872-blycbi4u	584	16	in	in	IN
cord-300872-blycbi4u	584	17	the	the	DT
cord-300872-blycbi4u	584	18	ORAC	ORAC	NNP
cord-300872-blycbi4u	584	19	assay	assay	NN
cord-300872-blycbi4u	584	20	(	(	-LRB-
cord-300872-blycbi4u	584	21	its	-PRON-	PRP$
cord-300872-blycbi4u	584	22	value	value	NN
cord-300872-blycbi4u	584	23	is	be	VBZ
cord-300872-blycbi4u	584	24	1.98	1.98	CD
cord-300872-blycbi4u	584	25	expressed	express	VBN
cord-300872-blycbi4u	584	26	as	as	IN
cord-300872-blycbi4u	584	27	Trolox	Trolox	NNP
cord-300872-blycbi4u	584	28	equivalents	equivalent	NNS
cord-300872-blycbi4u	584	29	)	)	-RRB-
cord-300872-blycbi4u	584	30	.	.	.
cord-300872-blycbi4u	585	1	In	in	IN
cord-300872-blycbi4u	585	2	this	this	DT
cord-300872-blycbi4u	585	3	respect	respect	NN
cord-300872-blycbi4u	585	4	,	,	,
cord-300872-blycbi4u	585	5	the	the	DT
cord-300872-blycbi4u	585	6	ORAC	orac	JJ
cord-300872-blycbi4u	585	7	value	value	NN
cord-300872-blycbi4u	585	8	of	of	IN
cord-300872-blycbi4u	585	9	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	585	10	activities	activity	NNS
cord-300872-blycbi4u	585	11	increases	increase	VBZ
cord-300872-blycbi4u	585	12	the	the	DT
cord-300872-blycbi4u	585	13	ability	ability	NN
cord-300872-blycbi4u	585	14	of	of	IN
cord-300872-blycbi4u	585	15	a	a	DT
cord-300872-blycbi4u	585	16	given	give	VBN
cord-300872-blycbi4u	585	17	compound	compound	NN
cord-300872-blycbi4u	585	18	as	as	IN
cord-300872-blycbi4u	585	19	the	the	DT
cord-300872-blycbi4u	585	20	antioxidant	antioxidant	NN
cord-300872-blycbi4u	585	21	becomes	become	VBZ
cord-300872-blycbi4u	585	22	better	well	JJR
cord-300872-blycbi4u	585	23	[	[	-LRB-
cord-300872-blycbi4u	585	24	58	58	CD
cord-300872-blycbi4u	585	25	]	]	-RRB-
cord-300872-blycbi4u	585	26	.	.	.
cord-300872-blycbi4u	586	1	Clioquinol	Clioquinol	NNP
cord-300872-blycbi4u	586	2	,	,	,
cord-300872-blycbi4u	586	3	rolipram	rolipram	NNP
cord-300872-blycbi4u	586	4	,	,	,
cord-300872-blycbi4u	586	5	and	and	CC
cord-300872-blycbi4u	586	6	roflumilast	roflumilast	NN
cord-300872-blycbi4u	586	7	showed	show	VBD
cord-300872-blycbi4u	586	8	values	value	NNS
cord-300872-blycbi4u	586	9	of	of	IN
cord-300872-blycbi4u	586	10	0.60	0.60	CD
cord-300872-blycbi4u	586	11	,	,	,
cord-300872-blycbi4u	586	12	0.070	0.070	CD
cord-300872-blycbi4u	586	13	,	,	,
cord-300872-blycbi4u	586	14	and	and	CC
cord-300872-blycbi4u	586	15	0.067	0.067	CD
cord-300872-blycbi4u	586	16	,	,	,
cord-300872-blycbi4u	586	17	respectively	respectively	RB
cord-300872-blycbi4u	586	18	.	.	.
cord-300872-blycbi4u	587	1	Oxidative	oxidative	JJ
cord-300872-blycbi4u	587	2	stress	stress	NN
cord-300872-blycbi4u	587	3	has	have	VBZ
cord-300872-blycbi4u	587	4	a	a	DT
cord-300872-blycbi4u	587	5	major	major	JJ
cord-300872-blycbi4u	587	6	effect	effect	NN
cord-300872-blycbi4u	587	7	in	in	IN
cord-300872-blycbi4u	587	8	the	the	DT
cord-300872-blycbi4u	587	9	production	production	NN
cord-300872-blycbi4u	587	10	of	of	IN
cord-300872-blycbi4u	587	11	excess	excess	JJ
cord-300872-blycbi4u	587	12	free	free	JJ
cord-300872-blycbi4u	587	13	radicals	radical	NNS
cord-300872-blycbi4u	587	14	,	,	,
cord-300872-blycbi4u	587	15	which	which	WDT
cord-300872-blycbi4u	587	16	lead	lead	VBP
cord-300872-blycbi4u	587	17	to	to	IN
cord-300872-blycbi4u	587	18	cell	cell	NN
cord-300872-blycbi4u	587	19	death	death	NN
cord-300872-blycbi4u	587	20	and	and	CC
cord-300872-blycbi4u	587	21	cytosceletal	cytosceletal	JJ
cord-300872-blycbi4u	587	22	damage	damage	NN
cord-300872-blycbi4u	587	23	in	in	IN
cord-300872-blycbi4u	587	24	AD	ad	NN
cord-300872-blycbi4u	587	25	[	[	-LRB-
cord-300872-blycbi4u	587	26	59	59	CD
cord-300872-blycbi4u	587	27	]	]	-RRB-
cord-300872-blycbi4u	587	28	.	.	.
cord-300872-blycbi4u	588	1	Finally	finally	RB
cord-300872-blycbi4u	588	2	,	,	,
cord-300872-blycbi4u	588	3	the	the	DT
cord-300872-blycbi4u	588	4	BBB	BBB	NNP
cord-300872-blycbi4u	588	5	has	have	VBZ
cord-300872-blycbi4u	588	6	a	a	DT
cord-300872-blycbi4u	588	7	major	major	JJ
cord-300872-blycbi4u	588	8	role	role	NN
cord-300872-blycbi4u	588	9	in	in	IN
cord-300872-blycbi4u	588	10	the	the	DT
cord-300872-blycbi4u	588	11	generation	generation	NN
cord-300872-blycbi4u	588	12	of	of	IN
cord-300872-blycbi4u	588	13	chronic	chronic	JJ
cord-300872-blycbi4u	588	14	brain	brain	NN
cord-300872-blycbi4u	588	15	inflammation	inflammation	NN
cord-300872-blycbi4u	588	16	during	during	IN
cord-300872-blycbi4u	588	17	AD	ad	NN
cord-300872-blycbi4u	588	18	[	[	-LRB-
cord-300872-blycbi4u	588	19	60	60	CD
cord-300872-blycbi4u	588	20	]	]	-RRB-
cord-300872-blycbi4u	588	21	.	.	.
cord-300872-blycbi4u	589	1	The	the	DT
cord-300872-blycbi4u	589	2	Pe	Pe	NNP
cord-300872-blycbi4u	589	3	values	value	NNS
cord-300872-blycbi4u	589	4	of	of	IN
cord-300872-blycbi4u	589	5	selected	select	VBN
cord-300872-blycbi4u	589	6	compounds	compound	NNS
cord-300872-blycbi4u	589	7	were	be	VBD
cord-300872-blycbi4u	589	8	evaluated	evaluate	VBN
cord-300872-blycbi4u	589	9	using	use	VBG
cord-300872-blycbi4u	589	10	PAMPA	PAMPA	NNP
cord-300872-blycbi4u	589	11	.	.	.
cord-300872-blycbi4u	590	1	The	the	DT
cord-300872-blycbi4u	590	2	results	result	NNS
cord-300872-blycbi4u	590	3	indicated	indicate	VBD
cord-300872-blycbi4u	590	4	that	that	IN
cord-300872-blycbi4u	590	5	a	a	DT
cord-300872-blycbi4u	590	6	derivative	derivative	NN
cord-300872-blycbi4u	590	7	of	of	IN
cord-300872-blycbi4u	590	8	87	87	CD
cord-300872-blycbi4u	590	9	with	with	IN
cord-300872-blycbi4u	590	10	R	r	NN
cord-300872-blycbi4u	590	11	1	1	CD
cord-300872-blycbi4u	590	12	=	=	SYM
cord-300872-blycbi4u	590	13	CH	CH	NNP
cord-300872-blycbi4u	590	14	3	3	CD
cord-300872-blycbi4u	590	15	and	and	CC
cord-300872-blycbi4u	590	16	R	r	NN
cord-300872-blycbi4u	590	17	2	2	CD
cord-300872-blycbi4u	591	1	=	=	NFP
cord-300872-blycbi4u	592	1	cyclopentylmethyl	cyclopentylmethyl	NNP
cord-300872-blycbi4u	592	2	exhibited	exhibit	VBD
cord-300872-blycbi4u	592	3	a	a	DT
cord-300872-blycbi4u	592	4	maximum	maximum	JJ
cord-300872-blycbi4u	592	5	value	value	NN
cord-300872-blycbi4u	592	6	of	of	IN
cord-300872-blycbi4u	592	7	Pe	Pe	NNP
cord-300872-blycbi4u	592	8	16.41	16.41	CD
cord-300872-blycbi4u	593	1	(	(	-LRB-
cord-300872-blycbi4u	593	2	±0.44	±0.44	NNP
cord-300872-blycbi4u	593	3	)	)	-RRB-
cord-300872-blycbi4u	593	4	×	×	NNP
cord-300872-blycbi4u	593	5	10	10	CD
cord-300872-blycbi4u	593	6	6	6	CD
cord-300872-blycbi4u	593	7	cm	cm	NNS
cord-300872-blycbi4u	593	8	s	s	NNP
cord-300872-blycbi4u	593	9	−1	−1	NNP
cord-300872-blycbi4u	593	10	,	,	,
cord-300872-blycbi4u	593	11	whereas	whereas	IN
cord-300872-blycbi4u	593	12	other	other	JJ
cord-300872-blycbi4u	593	13	tested	test	VBN
cord-300872-blycbi4u	593	14	compounds	compound	NNS
cord-300872-blycbi4u	593	15	showed	show	VBD
cord-300872-blycbi4u	593	16	values	value	NNS
cord-300872-blycbi4u	593	17	higher	high	JJR
cord-300872-blycbi4u	593	18	than	than	IN
cord-300872-blycbi4u	593	19	4.7	4.7	CD
cord-300872-blycbi4u	593	20	×	×	NN
cord-300872-blycbi4u	593	21	10	10	CD
cord-300872-blycbi4u	593	22	6	6	CD
cord-300872-blycbi4u	593	23	cm	cm	NNS
cord-300872-blycbi4u	593	24	s	s	NNP
cord-300872-blycbi4u	593	25	−1	−1	NNP
cord-300872-blycbi4u	593	26	,	,	,
cord-300872-blycbi4u	594	1	indicating	indicate	VBG
cord-300872-blycbi4u	594	2	that	that	IN
cord-300872-blycbi4u	594	3	these	these	DT
cord-300872-blycbi4u	594	4	compounds	compound	NNS
cord-300872-blycbi4u	594	5	may	may	MD
cord-300872-blycbi4u	594	6	cross	cross	VB
cord-300872-blycbi4u	594	7	the	the	DT
cord-300872-blycbi4u	594	8	BBB	BBB	NNP
cord-300872-blycbi4u	594	9	.	.	.
cord-300872-blycbi4u	595	1	The	the	DT
cord-300872-blycbi4u	595	2	Pe	Pe	NNP
cord-300872-blycbi4u	595	3	values	value	NNS
cord-300872-blycbi4u	595	4	for	for	IN
cord-300872-blycbi4u	595	5	rolipram	rolipram	NNP
cord-300872-blycbi4u	595	6	,	,	,
cord-300872-blycbi4u	595	7	roflumilast	roflumilast	NNP
cord-300872-blycbi4u	595	8	,	,	,
cord-300872-blycbi4u	595	9	and	and	CC
cord-300872-blycbi4u	595	10	clioquinol	clioquinol	NN
cord-300872-blycbi4u	595	11	were	be	VBD
cord-300872-blycbi4u	595	12	evaluated	evaluate	VBN
cord-300872-blycbi4u	595	13	as	as	IN
cord-300872-blycbi4u	595	14	(	(	-LRB-
cord-300872-blycbi4u	595	15	18.87	18.87	CD
cord-300872-blycbi4u	595	16	±	±	CD
cord-300872-blycbi4u	595	17	0.57	0.57	CD
cord-300872-blycbi4u	595	18	)	)	-RRB-
cord-300872-blycbi4u	595	19	,	,	,
cord-300872-blycbi4u	595	20	(	(	-LRB-
cord-300872-blycbi4u	595	21	9.22	9.22	CD
cord-300872-blycbi4u	595	22	±	±	CD
cord-300872-blycbi4u	595	23	0.62	0.62	CD
cord-300872-blycbi4u	595	24	)	)	-RRB-
cord-300872-blycbi4u	595	25	,	,	,
cord-300872-blycbi4u	595	26	and	and	CC
cord-300872-blycbi4u	596	1	(	(	-LRB-
cord-300872-blycbi4u	596	2	5.20	5.20	CD
cord-300872-blycbi4u	596	3	±	±	CD
cord-300872-blycbi4u	596	4	0.33	0.33	CD
cord-300872-blycbi4u	596	5	)	)	-RRB-
cord-300872-blycbi4u	596	6	×	×	NN
cord-300872-blycbi4u	596	7	10	10	CD
cord-300872-blycbi4u	596	8	6	6	CD
cord-300872-blycbi4u	596	9	cm	cm	NNS
cord-300872-blycbi4u	596	10	s	s	NNP
cord-300872-blycbi4u	596	11	−1	−1	NNP
cord-300872-blycbi4u	596	12	,	,	,
cord-300872-blycbi4u	596	13	respectively	respectively	RB
cord-300872-blycbi4u	596	14	.	.	.
cord-300872-blycbi4u	597	1	An	an	DT
cord-300872-blycbi4u	597	2	earlier	early	JJR
cord-300872-blycbi4u	597	3	paper	paper	NN
cord-300872-blycbi4u	597	4	by	by	IN
cord-300872-blycbi4u	597	5	Wang	Wang	NNP
cord-300872-blycbi4u	597	6	et	et	NNP
cord-300872-blycbi4u	597	7	al	al	NNP
cord-300872-blycbi4u	597	8	.	.	.
cord-300872-blycbi4u	598	1	(	(	-LRB-
cord-300872-blycbi4u	598	2	2018	2018	CD
cord-300872-blycbi4u	598	3	)	)	-RRB-
cord-300872-blycbi4u	598	4	described	describe	VBD
cord-300872-blycbi4u	598	5	the	the	DT
cord-300872-blycbi4u	598	6	synthesis	synthesis	NN
cord-300872-blycbi4u	598	7	of	of	IN
cord-300872-blycbi4u	598	8	new	new	JJ
cord-300872-blycbi4u	598	9	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	598	10	derivatives	derivative	NNS
cord-300872-blycbi4u	598	11	,	,	,
cord-300872-blycbi4u	598	12	as	as	IN
cord-300872-blycbi4u	598	13	shown	show	VBN
cord-300872-blycbi4u	598	14	in	in	IN
cord-300872-blycbi4u	598	15	Figure	figure	NN
cord-300872-blycbi4u	598	16	6	6	CD
cord-300872-blycbi4u	598	17	[	[	-LRB-
cord-300872-blycbi4u	598	18	61	61	CD
cord-300872-blycbi4u	598	19	]	]	-RRB-
cord-300872-blycbi4u	598	20	.	.	.
cord-300872-blycbi4u	599	1	Compounds	compound	NNS
cord-300872-blycbi4u	599	2	88	88	CD
cord-300872-blycbi4u	599	3	and	and	CC
cord-300872-blycbi4u	599	4	89	89	CD
cord-300872-blycbi4u	599	5	were	be	VBD
cord-300872-blycbi4u	599	6	prepared	prepare	VBN
cord-300872-blycbi4u	599	7	from	from	IN
cord-300872-blycbi4u	599	8	8-HQ	8-hq	CD
cord-300872-blycbi4u	599	9	by	by	IN
cord-300872-blycbi4u	599	10	reaction	reaction	NN
cord-300872-blycbi4u	599	11	first	first	RB
cord-300872-blycbi4u	599	12	with	with	IN
cord-300872-blycbi4u	599	13	formaldehyde	formaldehyde	NN
cord-300872-blycbi4u	599	14	in	in	IN
cord-300872-blycbi4u	599	15	the	the	DT
cord-300872-blycbi4u	599	16	presence	presence	NN
cord-300872-blycbi4u	599	17	of	of	IN
cord-300872-blycbi4u	599	18	hydrogen	hydrogen	NN
cord-300872-blycbi4u	599	19	chloride	chloride	NN
cord-300872-blycbi4u	599	20	,	,	,
cord-300872-blycbi4u	599	21	followed	follow	VBN
cord-300872-blycbi4u	599	22	by	by	IN
cord-300872-blycbi4u	599	23	reaction	reaction	NN
cord-300872-blycbi4u	599	24	with	with	IN
cord-300872-blycbi4u	599	25	triethylphosphite	triethylphosphite	NNP
cord-300872-blycbi4u	599	26	to	to	TO
cord-300872-blycbi4u	599	27	afford	afford	VB
cord-300872-blycbi4u	599	28	diethyl	diethyl	FW
cord-300872-blycbi4u	599	29	(	(	-LRB-
cord-300872-blycbi4u	599	30	(	(	-LRB-
cord-300872-blycbi4u	599	31	8-hydroxyquinolin-5-yl)methyl)phosphonate	8-hydroxyquinolin-5-yl)methyl)phosphonate	CD
cord-300872-blycbi4u	599	32	[	[	-LRB-
cord-300872-blycbi4u	599	33	56	56	CD
cord-300872-blycbi4u	599	34	]	]	-RRB-
cord-300872-blycbi4u	599	35	.	.	.
cord-300872-blycbi4u	600	1	In	in	IN
cord-300872-blycbi4u	600	2	this	this	DT
cord-300872-blycbi4u	600	3	reaction	reaction	NN
cord-300872-blycbi4u	600	4	,	,	,
cord-300872-blycbi4u	600	5	the	the	DT
cord-300872-blycbi4u	600	6	phenolic	phenolic	JJ
cord-300872-blycbi4u	600	7	group	group	NN
cord-300872-blycbi4u	600	8	was	be	VBD
cord-300872-blycbi4u	600	9	protected	protect	VBN
cord-300872-blycbi4u	600	10	via	via	IN
cord-300872-blycbi4u	600	11	reaction	reaction	NN
cord-300872-blycbi4u	600	12	with	with	IN
cord-300872-blycbi4u	600	13	chloro	chloro	NNP
cord-300872-blycbi4u	600	14	(	(	-LRB-
cord-300872-blycbi4u	600	15	methoxy)methane	methoxy)methane	NNP
cord-300872-blycbi4u	600	16	to	to	TO
cord-300872-blycbi4u	600	17	yield	yield	VB
cord-300872-blycbi4u	600	18	diethyl	diethyl	NNP
cord-300872-blycbi4u	600	19	(	(	-LRB-
cord-300872-blycbi4u	600	20	(	(	-LRB-
cord-300872-blycbi4u	600	21	8-(methoxymethoxy	8-(methoxymethoxy	CD
cord-300872-blycbi4u	600	22	)	)	-RRB-
cord-300872-blycbi4u	600	23	quinolin-5-yl)methyl)-phosphonate	quinolin-5-yl)methyl)-phosphonate	NN
cord-300872-blycbi4u	600	24	.	.	.
cord-300872-blycbi4u	601	1	Subsequent	subsequent	JJ
cord-300872-blycbi4u	601	2	reaction	reaction	NN
cord-300872-blycbi4u	601	3	of	of	IN
cord-300872-blycbi4u	601	4	the	the	DT
cord-300872-blycbi4u	601	5	last	last	JJ
cord-300872-blycbi4u	601	6	compound	compound	NN
cord-300872-blycbi4u	601	7	with	with	IN
cord-300872-blycbi4u	601	8	various	various	JJ
cord-300872-blycbi4u	601	9	2-nitrob	2-nitrob	CD
cord-300872-blycbi4u	601	10	enzaldehydes	enzaldehyde	NNS
cord-300872-blycbi4u	601	11	in	in	IN
cord-300872-blycbi4u	601	12	the	the	DT
cord-300872-blycbi4u	601	13	presence	presence	NN
cord-300872-blycbi4u	601	14	of	of	IN
cord-300872-blycbi4u	601	15	sodium	sodium	NN
cord-300872-blycbi4u	601	16	hydride	hydride	NN
cord-300872-blycbi4u	601	17	yielded	yield	VBD
cord-300872-blycbi4u	601	18	derivatives	derivative	NNS
cord-300872-blycbi4u	601	19	of	of	IN
cord-300872-blycbi4u	601	20	8-(methoxymethoxy)-5-(2-nitro	8-(methoxymethoxy)-5-(2-nitro	NNP
cord-300872-blycbi4u	601	21	styryl)quinolone	styryl)quinolone	NNP
cord-300872-blycbi4u	601	22	.	.	.
cord-300872-blycbi4u	602	1	Reductive	reductive	JJ
cord-300872-blycbi4u	602	2	cyclization	cyclization	NN
cord-300872-blycbi4u	602	3	of	of	IN
cord-300872-blycbi4u	602	4	2-nitrostyrenes	2-nitrostyrenes	CD
cord-300872-blycbi4u	602	5	with	with	IN
cord-300872-blycbi4u	602	6	carbon	carbon	NN
cord-300872-blycbi4u	602	7	monoxide	monoxide	NN
cord-300872-blycbi4u	602	8	followed	follow	VBN
cord-300872-blycbi4u	602	9	by	by	IN
cord-300872-blycbi4u	602	10	removal	removal	NN
cord-300872-blycbi4u	602	11	of	of	IN
cord-300872-blycbi4u	602	12	the	the	DT
cord-300872-blycbi4u	602	13	protecting	protect	VBG
cord-300872-blycbi4u	602	14	group	group	NN
cord-300872-blycbi4u	602	15	(	(	-LRB-
cord-300872-blycbi4u	602	16	methoxymethane	methoxymethane	NNP
cord-300872-blycbi4u	602	17	)	)	-RRB-
cord-300872-blycbi4u	602	18	by	by	IN
cord-300872-blycbi4u	602	19	hydrochloride	hydrochloride	NN
cord-300872-blycbi4u	602	20	solution	solution	NN
cord-300872-blycbi4u	602	21	led	lead	VBD
cord-300872-blycbi4u	602	22	to	to	IN
cord-300872-blycbi4u	602	23	the	the	DT
cord-300872-blycbi4u	602	24	formation	formation	NN
cord-300872-blycbi4u	602	25	of	of	IN
cord-300872-blycbi4u	602	26	the	the	DT
cord-300872-blycbi4u	602	27	final	final	JJ
cord-300872-blycbi4u	602	28	product	product	NN
cord-300872-blycbi4u	602	29	.	.	.
cord-300872-blycbi4u	603	1	For	for	IN
cord-300872-blycbi4u	603	2	compound	compound	NN
cord-300872-blycbi4u	603	3	89	89	CD
cord-300872-blycbi4u	603	4	,	,	,
cord-300872-blycbi4u	603	5	diethyl	diethyl	NNP
cord-300872-blycbi4u	603	6	(	(	-LRB-
cord-300872-blycbi4u	603	7	(	(	-LRB-
cord-300872-blycbi4u	603	8	7-chloro-8-hydroxyquinolin-5-yl)methyl)-phosphonate	7-chloro-8-hydroxyquinolin-5-yl)methyl)-phosphonate	JJ
cord-300872-blycbi4u	603	9	was	be	VBD
cord-300872-blycbi4u	603	10	prepared	prepare	VBN
cord-300872-blycbi4u	603	11	by	by	IN
cord-300872-blycbi4u	603	12	reacting	react	VBG
cord-300872-blycbi4u	603	13	diethyl	diethyl	NNP
cord-300872-blycbi4u	603	14	(	(	-LRB-
cord-300872-blycbi4u	603	15	(	(	-LRB-
cord-300872-blycbi4u	603	16	8-hydroxyquinolin-5-yl)methyl)phosphonate	8-hydroxyquinolin-5-yl)methyl)phosphonate	CD
cord-300872-blycbi4u	603	17	with	with	IN
cord-300872-blycbi4u	603	18	sodium	sodium	NN
cord-300872-blycbi4u	603	19	hypochlorite	hypochlorite	NN
cord-300872-blycbi4u	603	20	,	,	,
cord-300872-blycbi4u	603	21	followed	follow	VBN
cord-300872-blycbi4u	603	22	by	by	IN
cord-300872-blycbi4u	603	23	the	the	DT
cord-300872-blycbi4u	603	24	same	same	JJ
cord-300872-blycbi4u	603	25	previous	previous	JJ
cord-300872-blycbi4u	603	26	steps	step	NNS
cord-300872-blycbi4u	603	27	.	.	.
cord-300872-blycbi4u	604	1	On	on	IN
cord-300872-blycbi4u	604	2	the	the	DT
cord-300872-blycbi4u	604	3	other	other	JJ
cord-300872-blycbi4u	604	4	hand	hand	NN
cord-300872-blycbi4u	604	5	,	,	,
cord-300872-blycbi4u	604	6	compound	compound	NN
cord-300872-blycbi4u	604	7	91	91	CD
cord-300872-blycbi4u	604	8	was	be	VBD
cord-300872-blycbi4u	604	9	prepared	prepare	VBN
cord-300872-blycbi4u	604	10	through	through	IN
cord-300872-blycbi4u	604	11	a	a	DT
cord-300872-blycbi4u	604	12	series	series	NN
cord-300872-blycbi4u	604	13	of	of	IN
cord-300872-blycbi4u	604	14	steps	step	NNS
cord-300872-blycbi4u	604	15	that	that	WDT
cord-300872-blycbi4u	604	16	involved	involve	VBD
cord-300872-blycbi4u	604	17	reacting	react	VBG
cord-300872-blycbi4u	604	18	2-methyl-8-hydroxyqunolines	2-methyl-8-hydroxyqunolines	CD
cord-300872-blycbi4u	604	19	90	90	CD
cord-300872-blycbi4u	604	20	with	with	IN
cord-300872-blycbi4u	604	21	acetic	acetic	JJ
cord-300872-blycbi4u	604	22	anhydride	anhydride	NN
cord-300872-blycbi4u	604	23	,	,	,
cord-300872-blycbi4u	604	24	then	then	RB
cord-300872-blycbi4u	604	25	with	with	IN
cord-300872-blycbi4u	604	26	2-nitrobenzaldehydes	2-nitrobenzaldehydes	CD
cord-300872-blycbi4u	604	27	,	,	,
cord-300872-blycbi4u	604	28	followed	follow	VBN
cord-300872-blycbi4u	604	29	by	by	IN
cord-300872-blycbi4u	604	30	reductive	reductive	JJ
cord-300872-blycbi4u	604	31	cyclization	cyclization	NN
cord-300872-blycbi4u	604	32	of	of	IN
cord-300872-blycbi4u	604	33	2-nitrostyerenes	2-nitrostyerenes	CD
cord-300872-blycbi4u	604	34	in	in	IN
cord-300872-blycbi4u	604	35	the	the	DT
cord-300872-blycbi4u	604	36	presence	presence	NN
cord-300872-blycbi4u	604	37	of	of	IN
cord-300872-blycbi4u	604	38	the	the	DT
cord-300872-blycbi4u	604	39	palladium	palladium	NN
cord-300872-blycbi4u	604	40	(	(	-LRB-
cord-300872-blycbi4u	604	41	II	II	NNP
cord-300872-blycbi4u	604	42	)	)	-RRB-
cord-300872-blycbi4u	604	43	acetate	acetate	NN
cord-300872-blycbi4u	604	44	catalyst	catalyst	NN
cord-300872-blycbi4u	604	45	under	under	IN
cord-300872-blycbi4u	604	46	carbon	carbon	NN
cord-300872-blycbi4u	604	47	monoxide	monoxide	NN
cord-300872-blycbi4u	604	48	gas	gas	NN
cord-300872-blycbi4u	604	49	,	,	,
cord-300872-blycbi4u	604	50	and	and	CC
cord-300872-blycbi4u	604	51	finally	finally	RB
cord-300872-blycbi4u	604	52	with	with	IN
cord-300872-blycbi4u	604	53	a	a	DT
cord-300872-blycbi4u	604	54	base	base	NN
cord-300872-blycbi4u	604	55	(	(	-LRB-
cord-300872-blycbi4u	604	56	carbonate	carbonate	NN
cord-300872-blycbi4u	604	57	or	or	CC
cord-300872-blycbi4u	604	58	methoxide	methoxide	NN
cord-300872-blycbi4u	604	59	ions	ion	NNS
cord-300872-blycbi4u	604	60	,	,	,
cord-300872-blycbi4u	604	61	depending	depend	VBG
cord-300872-blycbi4u	604	62	on	on	IN
cord-300872-blycbi4u	604	63	the	the	DT
cord-300872-blycbi4u	604	64	nature	nature	NN
cord-300872-blycbi4u	604	65	of	of	IN
cord-300872-blycbi4u	604	66	X	x	NN
cord-300872-blycbi4u	604	67	)	)	-RRB-
cord-300872-blycbi4u	604	68	.	.	.
cord-300872-blycbi4u	605	1	Compounds	compound	NNS
cord-300872-blycbi4u	605	2	88	88	CD
cord-300872-blycbi4u	605	3	,	,	,
cord-300872-blycbi4u	605	4	89	89	CD
cord-300872-blycbi4u	605	5	,	,	,
cord-300872-blycbi4u	605	6	and	and	CC
cord-300872-blycbi4u	605	7	91	91	CD
cord-300872-blycbi4u	605	8	were	be	VBD
cord-300872-blycbi4u	605	9	tested	test	VBN
cord-300872-blycbi4u	605	10	against	against	IN
cord-300872-blycbi4u	605	11	the	the	DT
cord-300872-blycbi4u	605	12	ORAC	ORAC	NNP
cord-300872-blycbi4u	605	13	assay	assay	NN
cord-300872-blycbi4u	605	14	,	,	,
cord-300872-blycbi4u	605	15	BBB	BBB	NNP
cord-300872-blycbi4u	605	16	permeability	permeability	NN
cord-300872-blycbi4u	605	17	assay	assay	NN
cord-300872-blycbi4u	605	18	,	,	,
cord-300872-blycbi4u	605	19	and	and	CC
cord-300872-blycbi4u	605	20	inhibition	inhibition	NN
cord-300872-blycbi4u	605	21	activity	activity	NN
cord-300872-blycbi4u	605	22	towards	towards	IN
cord-300872-blycbi4u	605	23	amyloid	amyloid	NN
cord-300872-blycbi4u	605	24	beta	beta	NN
cord-300872-blycbi4u	605	25	(	(	-LRB-
cord-300872-blycbi4u	605	26	Aβ	Aβ	NNP
cord-300872-blycbi4u	605	27	)	)	-RRB-
cord-300872-blycbi4u	605	28	self	self	NN
cord-300872-blycbi4u	605	29	-	-	HYPH
cord-300872-blycbi4u	605	30	induced	induce	VBN
cord-300872-blycbi4u	605	31	aggregation	aggregation	NN
cord-300872-blycbi4u	605	32	.	.	.
cord-300872-blycbi4u	606	1	The	the	DT
cord-300872-blycbi4u	606	2	results	result	NNS
cord-300872-blycbi4u	606	3	revealed	reveal	VBD
cord-300872-blycbi4u	606	4	that	that	IN
cord-300872-blycbi4u	606	5	compounds	compound	NNS
cord-300872-blycbi4u	606	6	88	88	CD
cord-300872-blycbi4u	607	1	(	(	-LRB-
cord-300872-blycbi4u	607	2	R	r	NN
cord-300872-blycbi4u	607	3	=	=	SYM
cord-300872-blycbi4u	607	4	OH	OH	NNP
cord-300872-blycbi4u	607	5	)	)	-RRB-
cord-300872-blycbi4u	607	6	,	,	,
cord-300872-blycbi4u	607	7	89	89	CD
cord-300872-blycbi4u	608	1	(	(	-LRB-
cord-300872-blycbi4u	608	2	x	x	NN
cord-300872-blycbi4u	608	3	=	=	SYM
cord-300872-blycbi4u	608	4	H	h	NN
cord-300872-blycbi4u	608	5	,	,	,
cord-300872-blycbi4u	608	6	R	r	NN
cord-300872-blycbi4u	608	7	1	1	CD
cord-300872-blycbi4u	608	8	=	=	NFP
cord-300872-blycbi4u	609	1	OH	oh	UH
cord-300872-blycbi4u	609	2	,	,	,
cord-300872-blycbi4u	609	3	R	r	NN
cord-300872-blycbi4u	609	4	2	2	CD
cord-300872-blycbi4u	609	5	=	=	SYM
cord-300872-blycbi4u	609	6	H	h	NN
cord-300872-blycbi4u	609	7	)	)	-RRB-
cord-300872-blycbi4u	609	8	,	,	,
cord-300872-blycbi4u	609	9	and	and	CC
cord-300872-blycbi4u	609	10	91	91	CD
cord-300872-blycbi4u	610	1	(	(	-LRB-
cord-300872-blycbi4u	610	2	x	x	NN
cord-300872-blycbi4u	610	3	=	=	SYM
cord-300872-blycbi4u	610	4	H	h	NN
cord-300872-blycbi4u	610	5	,	,	,
cord-300872-blycbi4u	610	6	R	r	NN
cord-300872-blycbi4u	610	7	1	1	CD
cord-300872-blycbi4u	611	1	=	=	NFP
cord-300872-blycbi4u	612	1	OH	oh	UH
cord-300872-blycbi4u	612	2	,	,	,
cord-300872-blycbi4u	612	3	R	r	NN
cord-300872-blycbi4u	612	4	2	2	CD
cord-300872-blycbi4u	612	5	=	=	NN
cord-300872-blycbi4u	612	6	CH	CH	NNP
cord-300872-blycbi4u	612	7	3	3	CD
cord-300872-blycbi4u	612	8	)	)	-RRB-
cord-300872-blycbi4u	612	9	exhibited	exhibit	VBD
cord-300872-blycbi4u	612	10	the	the	DT
cord-300872-blycbi4u	612	11	highest	high	JJS
cord-300872-blycbi4u	612	12	activities	activity	NNS
cord-300872-blycbi4u	612	13	among	among	IN
cord-300872-blycbi4u	612	14	all	all	DT
cord-300872-blycbi4u	612	15	prepared	prepare	VBN
cord-300872-blycbi4u	612	16	compounds	compound	NNS
cord-300872-blycbi4u	612	17	(	(	-LRB-
cord-300872-blycbi4u	612	18	6.6	6.6	CD
cord-300872-blycbi4u	612	19	,	,	,
cord-300872-blycbi4u	612	20	5.3	5.3	CD
cord-300872-blycbi4u	612	21	,	,	,
cord-300872-blycbi4u	612	22	5.9	5.9	CD
cord-300872-blycbi4u	612	23	,	,	,
cord-300872-blycbi4u	612	24	and	and	CC
cord-300872-blycbi4u	612	25	5.4	5.4	CD
cord-300872-blycbi4u	612	26	,	,	,
cord-300872-blycbi4u	612	27	respectively	respectively	RB
cord-300872-blycbi4u	612	28	)	)	-RRB-
cord-300872-blycbi4u	612	29	.	.	.
cord-300872-blycbi4u	613	1	The	the	DT
cord-300872-blycbi4u	613	2	presence	presence	NN
cord-300872-blycbi4u	613	3	of	of	IN
cord-300872-blycbi4u	613	4	the	the	DT
cord-300872-blycbi4u	613	5	phenolic	phenolic	JJ
cord-300872-blycbi4u	613	6	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	613	7	group	group	NN
cord-300872-blycbi4u	613	8	at	at	IN
cord-300872-blycbi4u	613	9	C-5	C-5	NNP
cord-300872-blycbi4u	613	10	of	of	IN
cord-300872-blycbi4u	613	11	the	the	DT
cord-300872-blycbi4u	613	12	indole	indole	NN
cord-300872-blycbi4u	613	13	moiety	moiety	NN
cord-300872-blycbi4u	613	14	enhances	enhance	VBZ
cord-300872-blycbi4u	613	15	the	the	DT
cord-300872-blycbi4u	613	16	activity	activity	NN
cord-300872-blycbi4u	613	17	.	.	.
cord-300872-blycbi4u	614	1	On	on	IN
cord-300872-blycbi4u	614	2	the	the	DT
cord-300872-blycbi4u	614	3	other	other	JJ
cord-300872-blycbi4u	614	4	hand	hand	NN
cord-300872-blycbi4u	614	5	,	,	,
cord-300872-blycbi4u	614	6	the	the	DT
cord-300872-blycbi4u	614	7	presence	presence	NN
cord-300872-blycbi4u	614	8	of	of	IN
cord-300872-blycbi4u	614	9	a	a	DT
cord-300872-blycbi4u	614	10	chlorine	chlorine	NN
cord-300872-blycbi4u	614	11	atom	atom	NN
cord-300872-blycbi4u	614	12	in	in	IN
cord-300872-blycbi4u	614	13	compound	compound	NN
cord-300872-blycbi4u	614	14	89	89	CD
cord-300872-blycbi4u	614	15	lowers	lower	VBZ
cord-300872-blycbi4u	614	16	the	the	DT
cord-300872-blycbi4u	614	17	activity	activity	NN
cord-300872-blycbi4u	614	18	compared	compare	VBN
cord-300872-blycbi4u	614	19	to	to	IN
cord-300872-blycbi4u	614	20	a	a	DT
cord-300872-blycbi4u	614	21	hydrogen	hydrogen	NN
cord-300872-blycbi4u	614	22	.	.	.
cord-300872-blycbi4u	615	1	The	the	DT
cord-300872-blycbi4u	615	2	reference	reference	NN
cord-300872-blycbi4u	615	3	standards	standard	NNS
cord-300872-blycbi4u	615	4	,	,	,
cord-300872-blycbi4u	615	5	including	include	VBG
cord-300872-blycbi4u	615	6	clioquinol	clioquinol	NN
cord-300872-blycbi4u	615	7	,	,	,
cord-300872-blycbi4u	615	8	melatonin	melatonin	NN
cord-300872-blycbi4u	615	9	,	,	,
cord-300872-blycbi4u	615	10	and	and	CC
cord-300872-blycbi4u	615	11	a	a	DT
cord-300872-blycbi4u	615	12	mixture	mixture	NN
cord-300872-blycbi4u	615	13	of	of	IN
cord-300872-blycbi4u	615	14	clioquinol	clioquinol	NN
cord-300872-blycbi4u	615	15	and	and	CC
cord-300872-blycbi4u	615	16	melatonin	melatonin	NN
cord-300872-blycbi4u	615	17	,	,	,
cord-300872-blycbi4u	615	18	exhibit	exhibit	VBP
cord-300872-blycbi4u	615	19	the	the	DT
cord-300872-blycbi4u	615	20	values	value	NNS
cord-300872-blycbi4u	615	21	of	of	IN
cord-300872-blycbi4u	615	22	0.5	0.5	CD
cord-300872-blycbi4u	615	23	,	,	,
cord-300872-blycbi4u	615	24	2.4	2.4	CD
cord-300872-blycbi4u	615	25	,	,	,
cord-300872-blycbi4u	615	26	and	and	CC
cord-300872-blycbi4u	615	27	2.9	2.9	CD
cord-300872-blycbi4u	615	28	,	,	,
cord-300872-blycbi4u	615	29	respectively	respectively	RB
cord-300872-blycbi4u	615	30	.	.	.
cord-300872-blycbi4u	616	1	This	this	DT
cord-300872-blycbi4u	616	2	test	test	NN
cord-300872-blycbi4u	616	3	was	be	VBD
cord-300872-blycbi4u	616	4	performed	perform	VBN
cord-300872-blycbi4u	616	5	based	base	VBN
cord-300872-blycbi4u	616	6	on	on	IN
cord-300872-blycbi4u	616	7	a	a	DT
cord-300872-blycbi4u	616	8	fluorescein	fluorescein	NN
cord-300872-blycbi4u	616	9	(	(	-LRB-
cord-300872-blycbi4u	616	10	ORAC	ORAC	NNP
cord-300872-blycbi4u	616	11	-	-	HYPH
cord-300872-blycbi4u	616	12	FL	FL	NNP
cord-300872-blycbi4u	616	13	)	)	-RRB-
cord-300872-blycbi4u	616	14	method	method	NN
cord-300872-blycbi4u	616	15	with	with	IN
cord-300872-blycbi4u	616	16	a	a	DT
cord-300872-blycbi4u	616	17	Trolox	Trolox	NNP
cord-300872-blycbi4u	616	18	as	as	IN
cord-300872-blycbi4u	616	19	the	the	DT
cord-300872-blycbi4u	616	20	internal	internal	JJ
cord-300872-blycbi4u	616	21	standard	standard	NN
cord-300872-blycbi4u	616	22	.	.	.
cord-300872-blycbi4u	617	1	Similarly	similarly	RB
cord-300872-blycbi4u	617	2	,	,	,
cord-300872-blycbi4u	617	3	permeation	permeation	NN
cord-300872-blycbi4u	617	4	of	of	IN
cord-300872-blycbi4u	617	5	the	the	DT
cord-300872-blycbi4u	617	6	BBB	BBB	NNP
cord-300872-blycbi4u	617	7	is	be	VBZ
cord-300872-blycbi4u	617	8	considered	consider	VBN
cord-300872-blycbi4u	617	9	an	an	DT
cord-300872-blycbi4u	617	10	important	important	JJ
cord-300872-blycbi4u	617	11	parameter	parameter	NN
cord-300872-blycbi4u	617	12	for	for	IN
cord-300872-blycbi4u	617	13	potential	potential	JJ
cord-300872-blycbi4u	617	14	central	central	JJ
cord-300872-blycbi4u	617	15	nervous	nervous	JJ
cord-300872-blycbi4u	617	16	system	system	NN
cord-300872-blycbi4u	617	17	(	(	-LRB-
cord-300872-blycbi4u	617	18	CNS	CNS	NNP
cord-300872-blycbi4u	617	19	)	)	-RRB-
cord-300872-blycbi4u	617	20	candidates	candidate	NNS
cord-300872-blycbi4u	617	21	;	;	:
cord-300872-blycbi4u	617	22	this	this	DT
cord-300872-blycbi4u	617	23	assay	assay	NN
cord-300872-blycbi4u	617	24	was	be	VBD
cord-300872-blycbi4u	617	25	accomplished	accomplish	VBN
cord-300872-blycbi4u	617	26	using	use	VBG
cord-300872-blycbi4u	617	27	the	the	DT
cord-300872-blycbi4u	617	28	PARMA	PARMA	NNP
cord-300872-blycbi4u	617	29	method	method	NN
cord-300872-blycbi4u	617	30	.	.	.
cord-300872-blycbi4u	618	1	The	the	DT
cord-300872-blycbi4u	618	2	results	result	NNS
cord-300872-blycbi4u	618	3	showed	show	VBD
cord-300872-blycbi4u	618	4	that	that	IN
cord-300872-blycbi4u	618	5	most	most	JJS
cord-300872-blycbi4u	618	6	of	of	IN
cord-300872-blycbi4u	618	7	the	the	DT
cord-300872-blycbi4u	618	8	target	target	NN
cord-300872-blycbi4u	618	9	products	product	NNS
cord-300872-blycbi4u	618	10	could	could	MD
cord-300872-blycbi4u	618	11	effectively	effectively	RB
cord-300872-blycbi4u	618	12	permeate	permeate	VB
cord-300872-blycbi4u	618	13	the	the	DT
cord-300872-blycbi4u	618	14	BBB	BBB	NNP
cord-300872-blycbi4u	618	15	through	through	IN
cord-300872-blycbi4u	618	16	passive	passive	JJ
cord-300872-blycbi4u	618	17	diffusion	diffusion	NN
cord-300872-blycbi4u	618	18	.	.	.
cord-300872-blycbi4u	619	1	Two	two	CD
cord-300872-blycbi4u	619	2	compounds	compound	NNS
cord-300872-blycbi4u	619	3	of	of	IN
cord-300872-blycbi4u	619	4	series	series	NN
cord-300872-blycbi4u	619	5	91	91	CD
cord-300872-blycbi4u	619	6	,	,	,
cord-300872-blycbi4u	619	7	designated	designate	VBN
cord-300872-blycbi4u	619	8	as	as	IN
cord-300872-blycbi4u	619	9	x	x	NN
cord-300872-blycbi4u	619	10	=	=	SYM
cord-300872-blycbi4u	619	11	H	h	NN
cord-300872-blycbi4u	619	12	,	,	,
cord-300872-blycbi4u	619	13	R	r	NN
cord-300872-blycbi4u	619	14	1	1	CD
cord-300872-blycbi4u	620	1	=	=	NFP
cord-300872-blycbi4u	621	1	OH	oh	UH
cord-300872-blycbi4u	621	2	,	,	,
cord-300872-blycbi4u	621	3	R	r	NN
cord-300872-blycbi4u	621	4	2	2	CD
cord-300872-blycbi4u	621	5	=	=	SYM
cord-300872-blycbi4u	621	6	H	h	NN
cord-300872-blycbi4u	621	7	and	and	CC
cord-300872-blycbi4u	622	1	x	x	LS
cord-300872-blycbi4u	622	2	=	=	SYM
cord-300872-blycbi4u	622	3	H	h	NN
cord-300872-blycbi4u	622	4	,	,	,
cord-300872-blycbi4u	622	5	R	r	NN
cord-300872-blycbi4u	622	6	1	1	CD
cord-300872-blycbi4u	623	1	=	=	NFP
cord-300872-blycbi4u	624	1	OH	oh	UH
cord-300872-blycbi4u	624	2	,	,	,
cord-300872-blycbi4u	624	3	R	r	NN
cord-300872-blycbi4u	624	4	2	2	CD
cord-300872-blycbi4u	625	1	=	=	SYM
cord-300872-blycbi4u	625	2	OCH	OCH	NNP
cord-300872-blycbi4u	625	3	3	3	CD
cord-300872-blycbi4u	625	4	,	,	,
cord-300872-blycbi4u	625	5	showed	show	VBD
cord-300872-blycbi4u	625	6	higher	high	JJR
cord-300872-blycbi4u	625	7	BBB	BBB	NNP
cord-300872-blycbi4u	625	8	permeability	permeability	NN
cord-300872-blycbi4u	625	9	activity	activity	NN
cord-300872-blycbi4u	625	10	(	(	-LRB-
cord-300872-blycbi4u	625	11	Pe	Pe	NNP
cord-300872-blycbi4u	625	12	values	value	NNS
cord-300872-blycbi4u	625	13	14.8	14.8	CD
cord-300872-blycbi4u	625	14	and	and	CC
cord-300872-blycbi4u	625	15	12.1	12.1	CD
cord-300872-blycbi4u	625	16	,	,	,
cord-300872-blycbi4u	625	17	respectively	respectively	RB
cord-300872-blycbi4u	625	18	)	)	-RRB-
cord-300872-blycbi4u	625	19	compared	compare	VBN
cord-300872-blycbi4u	625	20	to	to	IN
cord-300872-blycbi4u	625	21	other	other	JJ
cord-300872-blycbi4u	625	22	derivatives	derivative	NNS
cord-300872-blycbi4u	625	23	that	that	WDT
cord-300872-blycbi4u	625	24	have	have	VBP
cord-300872-blycbi4u	625	25	a	a	DT
cord-300872-blycbi4u	625	26	hydrogen	hydrogen	NN
cord-300872-blycbi4u	625	27	atom	atom	NN
cord-300872-blycbi4u	625	28	instead	instead	RB
cord-300872-blycbi4u	625	29	of	of	IN
cord-300872-blycbi4u	625	30	the	the	DT
cord-300872-blycbi4u	625	31	phenolic	phenolic	JJ
cord-300872-blycbi4u	625	32	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	625	33	group	group	NN
cord-300872-blycbi4u	625	34	.	.	.
cord-300872-blycbi4u	626	1	In	in	IN
cord-300872-blycbi4u	626	2	contrast	contrast	NN
cord-300872-blycbi4u	626	3	,	,	,
cord-300872-blycbi4u	626	4	compounds	compound	NNS
cord-300872-blycbi4u	626	5	88	88	CD
cord-300872-blycbi4u	626	6	and	and	CC
cord-300872-blycbi4u	626	7	89	89	CD
cord-300872-blycbi4u	626	8	,	,	,
cord-300872-blycbi4u	626	9	bearing	bear	VBG
cord-300872-blycbi4u	626	10	the	the	DT
cord-300872-blycbi4u	626	11	indole	indole	NN
cord-300872-blycbi4u	626	12	moiety	moiety	NN
cord-300872-blycbi4u	626	13	at	at	IN
cord-300872-blycbi4u	626	14	position	position	NN
cord-300872-blycbi4u	626	15	5	5	CD
cord-300872-blycbi4u	626	16	of	of	IN
cord-300872-blycbi4u	626	17	the	the	DT
cord-300872-blycbi4u	626	18	quinolone	quinolone	NNP
cord-300872-blycbi4u	626	19	scaffold	scaffold	NN
cord-300872-blycbi4u	626	20	,	,	,
cord-300872-blycbi4u	626	21	gave	give	VBD
cord-300872-blycbi4u	626	22	Pe	Pe	NNP
cord-300872-blycbi4u	626	23	values	value	NNS
cord-300872-blycbi4u	626	24	of	of	IN
cord-300872-blycbi4u	626	25	9.1	9.1	CD
cord-300872-blycbi4u	626	26	and	and	CC
cord-300872-blycbi4u	626	27	6.8	6.8	CD
cord-300872-blycbi4u	626	28	,	,	,
cord-300872-blycbi4u	626	29	respectively	respectively	RB
cord-300872-blycbi4u	626	30	,	,	,
cord-300872-blycbi4u	626	31	even	even	RB
cord-300872-blycbi4u	626	32	in	in	IN
cord-300872-blycbi4u	626	33	the	the	DT
cord-300872-blycbi4u	626	34	presence	presence	NN
cord-300872-blycbi4u	626	35	of	of	IN
cord-300872-blycbi4u	626	36	a	a	DT
cord-300872-blycbi4u	626	37	phenolic	phenolic	JJ
cord-300872-blycbi4u	626	38	hydroxyl	hydroxyl	NN
cord-300872-blycbi4u	626	39	group	group	NN
cord-300872-blycbi4u	626	40	.	.	.
cord-300872-blycbi4u	627	1	Aβ	Aβ	NNP
cord-300872-blycbi4u	627	2	represents	represent	VBZ
cord-300872-blycbi4u	627	3	the	the	DT
cord-300872-blycbi4u	627	4	major	major	JJ
cord-300872-blycbi4u	627	5	component	component	NN
cord-300872-blycbi4u	627	6	of	of	IN
cord-300872-blycbi4u	627	7	amyloid	amyloid	NN
cord-300872-blycbi4u	627	8	plaques	plaque	NNS
cord-300872-blycbi4u	627	9	found	find	VBN
cord-300872-blycbi4u	627	10	in	in	IN
cord-300872-blycbi4u	627	11	the	the	DT
cord-300872-blycbi4u	627	12	brains	brain	NNS
cord-300872-blycbi4u	627	13	of	of	IN
cord-300872-blycbi4u	627	14	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	627	15	's	's	POS
cord-300872-blycbi4u	627	16	patients	patient	NNS
cord-300872-blycbi4u	627	17	[	[	-LRB-
cord-300872-blycbi4u	627	18	62	62	CD
cord-300872-blycbi4u	627	19	]	]	-RRB-
cord-300872-blycbi4u	627	20	.	.	.
cord-300872-blycbi4u	628	1	Inhibition	inhibition	NN
cord-300872-blycbi4u	628	2	of	of	IN
cord-300872-blycbi4u	628	3	Aβ	Aβ	NNP
cord-300872-blycbi4u	628	4	self	self	NN
cord-300872-blycbi4u	628	5	-	-	HYPH
cord-300872-blycbi4u	628	6	induced	induce	VBN
cord-300872-blycbi4u	628	7	aggregation	aggregation	NN
cord-300872-blycbi4u	628	8	for	for	IN
cord-300872-blycbi4u	628	9	the	the	DT
cord-300872-blycbi4u	628	10	prepared	prepared	JJ
cord-300872-blycbi4u	628	11	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	628	12	-	-	HYPH
cord-300872-blycbi4u	628	13	indole	indole	NN
cord-300872-blycbi4u	628	14	derivatives	derivative	NNS
cord-300872-blycbi4u	628	15	was	be	VBD
cord-300872-blycbi4u	628	16	examined	examine	VBN
cord-300872-blycbi4u	628	17	using	use	VBG
cord-300872-blycbi4u	628	18	thioflavin	thioflavin	NNP
cord-300872-blycbi4u	628	19	fluorescence	fluorescence	NN
cord-300872-blycbi4u	628	20	.	.	.
cord-300872-blycbi4u	629	1	One	one	CD
cord-300872-blycbi4u	629	2	of	of	IN
cord-300872-blycbi4u	629	3	the	the	DT
cord-300872-blycbi4u	629	4	derivatives	derivative	NNS
cord-300872-blycbi4u	629	5	of	of	IN
cord-300872-blycbi4u	629	6	91	91	CD
cord-300872-blycbi4u	629	7	,	,	,
cord-300872-blycbi4u	629	8	for	for	IN
cord-300872-blycbi4u	629	9	which	which	WDT
cord-300872-blycbi4u	629	10	X	x	NN
cord-300872-blycbi4u	629	11	=	=	NN
cord-300872-blycbi4u	629	12	H	h	NN
cord-300872-blycbi4u	629	13	,	,	,
cord-300872-blycbi4u	629	14	R	r	NN
cord-300872-blycbi4u	629	15	1	1	CD
cord-300872-blycbi4u	630	1	=	=	NFP
cord-300872-blycbi4u	631	1	OH	oh	UH
cord-300872-blycbi4u	631	2	,	,	,
cord-300872-blycbi4u	631	3	R	r	NN
cord-300872-blycbi4u	631	4	2	2	CD
cord-300872-blycbi4u	631	5	=	=	SYM
cord-300872-blycbi4u	631	6	H	h	NN
cord-300872-blycbi4u	631	7	,	,	,
cord-300872-blycbi4u	631	8	caused	cause	VBD
cord-300872-blycbi4u	631	9	51.2	51.2	CD
cord-300872-blycbi4u	631	10	%	%	NN
cord-300872-blycbi4u	631	11	percent	percent	NN
cord-300872-blycbi4u	631	12	inhibition	inhibition	NN
cord-300872-blycbi4u	631	13	,	,	,
cord-300872-blycbi4u	631	14	which	which	WDT
cord-300872-blycbi4u	631	15	was	be	VBD
cord-300872-blycbi4u	631	16	the	the	DT
cord-300872-blycbi4u	631	17	highest	high	JJS
cord-300872-blycbi4u	631	18	percentage	percentage	NN
cord-300872-blycbi4u	631	19	among	among	IN
cord-300872-blycbi4u	631	20	the	the	DT
cord-300872-blycbi4u	631	21	prepared	prepared	JJ
cord-300872-blycbi4u	631	22	compounds	compound	NNS
cord-300872-blycbi4u	631	23	.	.	.
cord-300872-blycbi4u	632	1	On	on	IN
cord-300872-blycbi4u	632	2	the	the	DT
cord-300872-blycbi4u	632	3	other	other	JJ
cord-300872-blycbi4u	632	4	hand	hand	NN
cord-300872-blycbi4u	632	5	,	,	,
cord-300872-blycbi4u	632	6	compounds	compound	VBZ
cord-300872-blycbi4u	632	7	88	88	CD
cord-300872-blycbi4u	632	8	and	and	CC
cord-300872-blycbi4u	632	9	89	89	CD
cord-300872-blycbi4u	632	10	caused	cause	VBD
cord-300872-blycbi4u	632	11	57.2	57.2	CD
cord-300872-blycbi4u	632	12	%	%	NN
cord-300872-blycbi4u	632	13	and	and	CC
cord-300872-blycbi4u	632	14	68.7	68.7	CD
cord-300872-blycbi4u	632	15	%	%	NN
cord-300872-blycbi4u	632	16	inhibition	inhibition	NN
cord-300872-blycbi4u	632	17	,	,	,
cord-300872-blycbi4u	632	18	respectively	respectively	RB
cord-300872-blycbi4u	632	19	;	;	:
cord-300872-blycbi4u	632	20	whereas	whereas	IN
cord-300872-blycbi4u	632	21	clioquinol	clioquinol	NN
cord-300872-blycbi4u	632	22	,	,	,
cord-300872-blycbi4u	632	23	curcumin	curcumin	NN
cord-300872-blycbi4u	632	24	,	,	,
cord-300872-blycbi4u	632	25	and	and	CC
cord-300872-blycbi4u	632	26	resveratrol	resveratrol	NN
cord-300872-blycbi4u	632	27	showed	show	VBD
cord-300872-blycbi4u	632	28	1.9	1.9	CD
cord-300872-blycbi4u	632	29	%	%	NN
cord-300872-blycbi4u	632	30	,	,	,
cord-300872-blycbi4u	632	31	36.7	36.7	CD
cord-300872-blycbi4u	632	32	%	%	NN
cord-300872-blycbi4u	632	33	,	,	,
cord-300872-blycbi4u	632	34	and	and	CC
cord-300872-blycbi4u	632	35	42.1	42.1	CD
cord-300872-blycbi4u	632	36	%	%	NN
cord-300872-blycbi4u	632	37	inhibition	inhibition	NN
cord-300872-blycbi4u	632	38	,	,	,
cord-300872-blycbi4u	632	39	respectively	respectively	RB
cord-300872-blycbi4u	632	40	.	.	.
cord-300872-blycbi4u	633	1	In	in	IN
cord-300872-blycbi4u	633	2	a	a	DT
cord-300872-blycbi4u	633	3	recent	recent	JJ
cord-300872-blycbi4u	633	4	publication	publication	NN
cord-300872-blycbi4u	633	5	,	,	,
cord-300872-blycbi4u	633	6	Prati	Prati	NNP
cord-300872-blycbi4u	633	7	and	and	CC
cord-300872-blycbi4u	633	8	coworkers	coworker	NNS
cord-300872-blycbi4u	633	9	[	[	-LRB-
cord-300872-blycbi4u	633	10	63	63	CD
cord-300872-blycbi4u	633	11	]	]	-RRB-
cord-300872-blycbi4u	633	12	described	describe	VBD
cord-300872-blycbi4u	633	13	the	the	DT
cord-300872-blycbi4u	633	14	synthesis	synthesis	NN
cord-300872-blycbi4u	633	15	of	of	IN
cord-300872-blycbi4u	633	16	a	a	DT
cord-300872-blycbi4u	633	17	new	new	JJ
cord-300872-blycbi4u	633	18	series	series	NN
cord-300872-blycbi4u	633	19	of	of	IN
cord-300872-blycbi4u	633	20	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	633	21	derivatives	derivative	NNS
cord-300872-blycbi4u	633	22	(	(	-LRB-
cord-300872-blycbi4u	633	23	94	94	CD
cord-300872-blycbi4u	633	24	)	)	-RRB-
cord-300872-blycbi4u	633	25	for	for	IN
cord-300872-blycbi4u	633	26	which	which	WDT
cord-300872-blycbi4u	633	27	the	the	DT
cord-300872-blycbi4u	633	28	products	product	NNS
cord-300872-blycbi4u	633	29	possess	possess	VBP
cord-300872-blycbi4u	633	30	structural	structural	JJ
cord-300872-blycbi4u	633	31	features	feature	NNS
cord-300872-blycbi4u	633	32	of	of	IN
cord-300872-blycbi4u	633	33	two	two	CD
cord-300872-blycbi4u	633	34	commercial	commercial	JJ
cord-300872-blycbi4u	633	35	drugs	drug	NNS
cord-300872-blycbi4u	633	36	,	,	,
cord-300872-blycbi4u	633	37	namely	namely	RB
cord-300872-blycbi4u	633	38	donepezil	donepezil	NNP
cord-300872-blycbi4u	633	39	and	and	CC
cord-300872-blycbi4u	633	40	clioquinol	clioquinol	NNP
cord-300872-blycbi4u	633	41	.	.	.
cord-300872-blycbi4u	634	1	Depicted	depict	VBN
cord-300872-blycbi4u	634	2	in	in	IN
cord-300872-blycbi4u	634	3	Scheme	Scheme	NNP
cord-300872-blycbi4u	634	4	22	22	CD
cord-300872-blycbi4u	634	5	are	be	VBP
cord-300872-blycbi4u	634	6	the	the	DT
cord-300872-blycbi4u	634	7	steps	step	NNS
cord-300872-blycbi4u	634	8	involved	involve	VBN
cord-300872-blycbi4u	634	9	in	in	IN
cord-300872-blycbi4u	634	10	the	the	DT
cord-300872-blycbi4u	634	11	synthesis	synthesis	NN
cord-300872-blycbi4u	634	12	of	of	IN
cord-300872-blycbi4u	634	13	these	these	DT
cord-300872-blycbi4u	634	14	compounds	compound	NNS
cord-300872-blycbi4u	634	15	.	.	.
cord-300872-blycbi4u	635	1	In	in	IN
cord-300872-blycbi4u	635	2	a	a	DT
cord-300872-blycbi4u	635	3	recent	recent	JJ
cord-300872-blycbi4u	635	4	publication	publication	NN
cord-300872-blycbi4u	635	5	,	,	,
cord-300872-blycbi4u	635	6	Prati	Prati	NNP
cord-300872-blycbi4u	635	7	and	and	CC
cord-300872-blycbi4u	635	8	coworkers	coworker	NNS
cord-300872-blycbi4u	635	9	[	[	-LRB-
cord-300872-blycbi4u	635	10	63	63	CD
cord-300872-blycbi4u	635	11	]	]	-RRB-
cord-300872-blycbi4u	636	1	This	this	DT
cord-300872-blycbi4u	636	2	synthesis	synthesis	NN
cord-300872-blycbi4u	636	3	was	be	VBD
cord-300872-blycbi4u	636	4	a	a	DT
cord-300872-blycbi4u	636	5	multicomponent	multicomponent	JJ
cord-300872-blycbi4u	636	6	Mannich	Mannich	NNP
cord-300872-blycbi4u	636	7	reaction	reaction	NN
cord-300872-blycbi4u	636	8	that	that	WDT
cord-300872-blycbi4u	636	9	involved	involve	VBD
cord-300872-blycbi4u	636	10	a	a	DT
cord-300872-blycbi4u	636	11	mixture	mixture	NN
cord-300872-blycbi4u	636	12	containing	contain	VBG
cord-300872-blycbi4u	636	13	piperazine	piperazine	NN
cord-300872-blycbi4u	636	14	(	(	-LRB-
cord-300872-blycbi4u	636	15	92	92	CD
cord-300872-blycbi4u	636	16	)	)	-RRB-
cord-300872-blycbi4u	636	17	,	,	,
cord-300872-blycbi4u	636	18	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	636	19	,	,	,
cord-300872-blycbi4u	636	20	and	and	CC
cord-300872-blycbi4u	636	21	8-HQ	8-hq	CD
cord-300872-blycbi4u	636	22	or	or	CC
cord-300872-blycbi4u	636	23	its	-PRON-	PRP$
cord-300872-blycbi4u	636	24	5-chloroanalogue	5-chloroanalogue	CD
cord-300872-blycbi4u	636	25	under	under	IN
cord-300872-blycbi4u	636	26	a	a	DT
cord-300872-blycbi4u	636	27	microwave	microwave	NN
cord-300872-blycbi4u	636	28	-	-	HYPH
cord-300872-blycbi4u	636	29	assisted	assist	VBN
cord-300872-blycbi4u	636	30	procedure	procedure	NN
cord-300872-blycbi4u	636	31	to	to	TO
cord-300872-blycbi4u	636	32	afford	afford	VB
cord-300872-blycbi4u	636	33	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	CD
cord-300872-blycbi4u	636	34	(	(	-LRB-
cord-300872-blycbi4u	636	35	93	93	CD
cord-300872-blycbi4u	636	36	)	)	-RRB-
cord-300872-blycbi4u	636	37	.	.	.
cord-300872-blycbi4u	637	1	This	this	DT
cord-300872-blycbi4u	637	2	synthon	synthon	NN
cord-300872-blycbi4u	637	3	was	be	VBD
cord-300872-blycbi4u	637	4	then	then	RB
cord-300872-blycbi4u	637	5	reacted	react	VBN
cord-300872-blycbi4u	637	6	with	with	IN
cord-300872-blycbi4u	637	7	various	various	JJ
cord-300872-blycbi4u	637	8	benzyl	benzyl	NN
cord-300872-blycbi4u	637	9	chlorides	chloride	NNS
cord-300872-blycbi4u	637	10	in	in	IN
cord-300872-blycbi4u	637	11	DMF	DMF	NNP
cord-300872-blycbi4u	637	12	.	.	.
cord-300872-blycbi4u	638	1	Compound	compound	NN
cord-300872-blycbi4u	638	2	94	94	CD
cord-300872-blycbi4u	638	3	and	and	CC
cord-300872-blycbi4u	638	4	its	-PRON-	PRP$
cord-300872-blycbi4u	638	5	derivatives	derivative	NNS
cord-300872-blycbi4u	638	6	were	be	VBD
cord-300872-blycbi4u	638	7	assayed	assay	VBN
cord-300872-blycbi4u	638	8	for	for	IN
cord-300872-blycbi4u	638	9	potential	potential	JJ
cord-300872-blycbi4u	638	10	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	638	11	activity	activity	NN
cord-300872-blycbi4u	638	12	towards	towards	IN
cord-300872-blycbi4u	638	13	human	human	JJ
cord-300872-blycbi4u	638	14	anti	anti	JJ
cord-300872-blycbi4u	638	15	-	-	JJ
cord-300872-blycbi4u	638	16	hAChE	hache	JJ
cord-300872-blycbi4u	638	17	and	and	CC
cord-300872-blycbi4u	638	18	anti	anti	NNS
cord-300872-blycbi4u	638	19	-	-	NN
cord-300872-blycbi4u	638	20	hBChE.	hbche.	XX
cord-300872-blycbi4u	639	1	The	the	DT
cord-300872-blycbi4u	639	2	results	result	NNS
cord-300872-blycbi4u	639	3	indicated	indicate	VBD
cord-300872-blycbi4u	639	4	that	that	IN
cord-300872-blycbi4u	639	5	at	at	IN
cord-300872-blycbi4u	639	6	a	a	DT
cord-300872-blycbi4u	639	7	concentration	concentration	NN
cord-300872-blycbi4u	639	8	of	of	IN
cord-300872-blycbi4u	639	9	40	40	CD
cord-300872-blycbi4u	639	10	mM	mm	CD
cord-300872-blycbi4u	639	11	,	,	,
cord-300872-blycbi4u	639	12	all	all	DT
cord-300872-blycbi4u	639	13	derivatives	derivative	NNS
cord-300872-blycbi4u	639	14	exhibited	exhibit	VBD
cord-300872-blycbi4u	639	15	inhibition	inhibition	NN
cord-300872-blycbi4u	639	16	,	,	,
cord-300872-blycbi4u	639	17	with	with	IN
cord-300872-blycbi4u	639	18	values	value	NNS
cord-300872-blycbi4u	639	19	ranging	range	VBG
cord-300872-blycbi4u	639	20	from	from	IN
cord-300872-blycbi4u	639	21	9.0	9.0	CD
cord-300872-blycbi4u	639	22	to	to	IN
cord-300872-blycbi4u	639	23	63.8	63.8	CD
cord-300872-blycbi4u	639	24	%	%	NN
cord-300872-blycbi4u	639	25	and	and	CC
cord-300872-blycbi4u	639	26	49.2	49.2	CD
cord-300872-blycbi4u	639	27	to	to	IN
cord-300872-blycbi4u	639	28	89.1	89.1	CD
cord-300872-blycbi4u	639	29	%	%	NN
cord-300872-blycbi4u	639	30	for	for	IN
cord-300872-blycbi4u	639	31	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	639	32	and	and	CC
cord-300872-blycbi4u	639	33	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	639	34	derivatives	derivative	NNS
cord-300872-blycbi4u	639	35	,	,	,
cord-300872-blycbi4u	639	36	respectively	respectively	RB
cord-300872-blycbi4u	639	37	,	,	,
cord-300872-blycbi4u	639	38	against	against	IN
cord-300872-blycbi4u	639	39	hBChE.	hbche.	XX
cord-300872-blycbi4u	640	1	However	however	RB
cord-300872-blycbi4u	640	2	,	,	,
cord-300872-blycbi4u	640	3	these	these	DT
cord-300872-blycbi4u	640	4	compounds	compound	NNS
cord-300872-blycbi4u	640	5	were	be	VBD
cord-300872-blycbi4u	640	6	inactive	inactive	JJ
cord-300872-blycbi4u	640	7	or	or	CC
cord-300872-blycbi4u	640	8	showed	show	VBD
cord-300872-blycbi4u	640	9	very	very	RB
cord-300872-blycbi4u	640	10	weak	weak	JJ
cord-300872-blycbi4u	640	11	inhibition	inhibition	NN
cord-300872-blycbi4u	640	12	activity	activity	NN
cord-300872-blycbi4u	640	13	against	against	IN
cord-300872-blycbi4u	640	14	hAChE	hAChE	NNP
cord-300872-blycbi4u	640	15	,	,	,
cord-300872-blycbi4u	640	16	suggesting	suggest	VBG
cord-300872-blycbi4u	640	17	selectivity	selectivity	NN
cord-300872-blycbi4u	640	18	of	of	IN
cord-300872-blycbi4u	640	19	the	the	DT
cord-300872-blycbi4u	640	20	target	target	NN
cord-300872-blycbi4u	640	21	products	product	NNS
cord-300872-blycbi4u	640	22	towards	towards	IN
cord-300872-blycbi4u	640	23	hBChE.	hbche.	XX
cord-300872-blycbi4u	641	1	In	in	IN
cord-300872-blycbi4u	641	2	addition	addition	NN
cord-300872-blycbi4u	641	3	,	,	,
cord-300872-blycbi4u	641	4	these	these	DT
cord-300872-blycbi4u	641	5	results	result	NNS
cord-300872-blycbi4u	641	6	highlighted	highlight	VBD
cord-300872-blycbi4u	641	7	the	the	DT
cord-300872-blycbi4u	641	8	effect	effect	NN
cord-300872-blycbi4u	641	9	of	of	IN
cord-300872-blycbi4u	641	10	the	the	DT
cord-300872-blycbi4u	641	11	chlorine	chlorine	NN
cord-300872-blycbi4u	641	12	atom	atom	NN
cord-300872-blycbi4u	641	13	at	at	IN
cord-300872-blycbi4u	641	14	position	position	NN
cord-300872-blycbi4u	641	15	5	5	CD
cord-300872-blycbi4u	641	16	of	of	IN
cord-300872-blycbi4u	641	17	the	the	DT
cord-300872-blycbi4u	641	18	8hydroxyquinoline	8hydroxyquinoline	CD
cord-300872-blycbi4u	641	19	moiety	moiety	NN
cord-300872-blycbi4u	641	20	on	on	IN
cord-300872-blycbi4u	641	21	the	the	DT
cord-300872-blycbi4u	641	22	activity	activity	NN
cord-300872-blycbi4u	641	23	compared	compare	VBN
cord-300872-blycbi4u	641	24	to	to	IN
cord-300872-blycbi4u	641	25	the	the	DT
cord-300872-blycbi4u	641	26	hydrogen	hydrogen	NN
cord-300872-blycbi4u	641	27	atom	atom	NN
cord-300872-blycbi4u	641	28	.	.	.
cord-300872-blycbi4u	642	1	The	the	DT
cord-300872-blycbi4u	642	2	chemical	chemical	NN
cord-300872-blycbi4u	642	3	references	reference	NNS
cord-300872-blycbi4u	642	4	This	this	DT
cord-300872-blycbi4u	642	5	synthesis	synthesis	NN
cord-300872-blycbi4u	642	6	was	be	VBD
cord-300872-blycbi4u	642	7	a	a	DT
cord-300872-blycbi4u	642	8	multicomponent	multicomponent	JJ
cord-300872-blycbi4u	642	9	Mannich	Mannich	NNP
cord-300872-blycbi4u	642	10	reaction	reaction	NN
cord-300872-blycbi4u	642	11	that	that	WDT
cord-300872-blycbi4u	642	12	involved	involve	VBD
cord-300872-blycbi4u	642	13	a	a	DT
cord-300872-blycbi4u	642	14	mixture	mixture	NN
cord-300872-blycbi4u	642	15	containing	contain	VBG
cord-300872-blycbi4u	642	16	piperazine	piperazine	NN
cord-300872-blycbi4u	642	17	(	(	-LRB-
cord-300872-blycbi4u	642	18	92	92	CD
cord-300872-blycbi4u	642	19	)	)	-RRB-
cord-300872-blycbi4u	642	20	,	,	,
cord-300872-blycbi4u	642	21	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	642	22	,	,	,
cord-300872-blycbi4u	642	23	and	and	CC
cord-300872-blycbi4u	642	24	8-HQ	8-hq	CD
cord-300872-blycbi4u	642	25	or	or	CC
cord-300872-blycbi4u	642	26	its	-PRON-	PRP$
cord-300872-blycbi4u	642	27	5-chloroanalogue	5-chloroanalogue	CD
cord-300872-blycbi4u	642	28	under	under	IN
cord-300872-blycbi4u	642	29	a	a	DT
cord-300872-blycbi4u	642	30	microwave	microwave	NN
cord-300872-blycbi4u	642	31	-	-	HYPH
cord-300872-blycbi4u	642	32	assisted	assist	VBN
cord-300872-blycbi4u	642	33	procedure	procedure	NN
cord-300872-blycbi4u	642	34	to	to	TO
cord-300872-blycbi4u	642	35	afford	afford	VB
cord-300872-blycbi4u	642	36	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	CD
cord-300872-blycbi4u	642	37	(	(	-LRB-
cord-300872-blycbi4u	642	38	93	93	CD
cord-300872-blycbi4u	642	39	)	)	-RRB-
cord-300872-blycbi4u	642	40	.	.	.
cord-300872-blycbi4u	643	1	This	this	DT
cord-300872-blycbi4u	643	2	synthon	synthon	NN
cord-300872-blycbi4u	643	3	was	be	VBD
cord-300872-blycbi4u	643	4	then	then	RB
cord-300872-blycbi4u	643	5	reacted	react	VBN
cord-300872-blycbi4u	643	6	with	with	IN
cord-300872-blycbi4u	643	7	various	various	JJ
cord-300872-blycbi4u	643	8	benzyl	benzyl	NN
cord-300872-blycbi4u	643	9	chlorides	chloride	NNS
cord-300872-blycbi4u	643	10	in	in	IN
cord-300872-blycbi4u	643	11	DMF	DMF	NNP
cord-300872-blycbi4u	643	12	.	.	.
cord-300872-blycbi4u	644	1	Compound	compound	NN
cord-300872-blycbi4u	644	2	94	94	CD
cord-300872-blycbi4u	644	3	and	and	CC
cord-300872-blycbi4u	644	4	its	-PRON-	PRP$
cord-300872-blycbi4u	644	5	derivatives	derivative	NNS
cord-300872-blycbi4u	644	6	were	be	VBD
cord-300872-blycbi4u	644	7	assayed	assay	VBN
cord-300872-blycbi4u	644	8	for	for	IN
cord-300872-blycbi4u	644	9	potential	potential	JJ
cord-300872-blycbi4u	644	10	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	644	11	activity	activity	NN
cord-300872-blycbi4u	644	12	towards	towards	IN
cord-300872-blycbi4u	644	13	human	human	JJ
cord-300872-blycbi4u	644	14	anti	anti	JJ
cord-300872-blycbi4u	644	15	-	-	JJ
cord-300872-blycbi4u	644	16	hAChE	hache	JJ
cord-300872-blycbi4u	644	17	and	and	CC
cord-300872-blycbi4u	644	18	anti	anti	NNS
cord-300872-blycbi4u	644	19	-	-	NN
cord-300872-blycbi4u	644	20	hBChE.	hbche.	XX
cord-300872-blycbi4u	645	1	The	the	DT
cord-300872-blycbi4u	645	2	results	result	NNS
cord-300872-blycbi4u	645	3	indicated	indicate	VBD
cord-300872-blycbi4u	645	4	that	that	IN
cord-300872-blycbi4u	645	5	at	at	IN
cord-300872-blycbi4u	645	6	a	a	DT
cord-300872-blycbi4u	645	7	concentration	concentration	NN
cord-300872-blycbi4u	645	8	of	of	IN
cord-300872-blycbi4u	645	9	40	40	CD
cord-300872-blycbi4u	645	10	mM	mm	CD
cord-300872-blycbi4u	645	11	,	,	,
cord-300872-blycbi4u	645	12	all	all	DT
cord-300872-blycbi4u	645	13	derivatives	derivative	NNS
cord-300872-blycbi4u	645	14	exhibited	exhibit	VBD
cord-300872-blycbi4u	645	15	inhibition	inhibition	NN
cord-300872-blycbi4u	645	16	,	,	,
cord-300872-blycbi4u	645	17	with	with	IN
cord-300872-blycbi4u	645	18	values	value	NNS
cord-300872-blycbi4u	645	19	ranging	range	VBG
cord-300872-blycbi4u	645	20	from	from	IN
cord-300872-blycbi4u	645	21	9.0	9.0	CD
cord-300872-blycbi4u	645	22	to	to	IN
cord-300872-blycbi4u	645	23	63.8	63.8	CD
cord-300872-blycbi4u	645	24	%	%	NN
cord-300872-blycbi4u	645	25	and	and	CC
cord-300872-blycbi4u	645	26	49.2	49.2	CD
cord-300872-blycbi4u	645	27	to	to	IN
cord-300872-blycbi4u	645	28	89.1	89.1	CD
cord-300872-blycbi4u	645	29	%	%	NN
cord-300872-blycbi4u	645	30	for	for	IN
cord-300872-blycbi4u	645	31	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	645	32	and	and	CC
cord-300872-blycbi4u	645	33	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	645	34	derivatives	derivative	NNS
cord-300872-blycbi4u	645	35	,	,	,
cord-300872-blycbi4u	645	36	respectively	respectively	RB
cord-300872-blycbi4u	645	37	,	,	,
cord-300872-blycbi4u	645	38	against	against	IN
cord-300872-blycbi4u	645	39	hBChE.	hbche.	XX
cord-300872-blycbi4u	646	1	However	however	RB
cord-300872-blycbi4u	646	2	,	,	,
cord-300872-blycbi4u	646	3	these	these	DT
cord-300872-blycbi4u	646	4	compounds	compound	NNS
cord-300872-blycbi4u	646	5	were	be	VBD
cord-300872-blycbi4u	646	6	inactive	inactive	JJ
cord-300872-blycbi4u	646	7	or	or	CC
cord-300872-blycbi4u	646	8	showed	show	VBD
cord-300872-blycbi4u	646	9	very	very	RB
cord-300872-blycbi4u	646	10	weak	weak	JJ
cord-300872-blycbi4u	646	11	inhibition	inhibition	NN
cord-300872-blycbi4u	646	12	activity	activity	NN
cord-300872-blycbi4u	646	13	against	against	IN
cord-300872-blycbi4u	646	14	hAChE	hAChE	NNP
cord-300872-blycbi4u	646	15	,	,	,
cord-300872-blycbi4u	646	16	suggesting	suggest	VBG
cord-300872-blycbi4u	646	17	selectivity	selectivity	NN
cord-300872-blycbi4u	646	18	of	of	IN
cord-300872-blycbi4u	646	19	the	the	DT
cord-300872-blycbi4u	646	20	target	target	NN
cord-300872-blycbi4u	646	21	products	product	NNS
cord-300872-blycbi4u	646	22	towards	towards	IN
cord-300872-blycbi4u	646	23	hBChE.	hbche.	XX
cord-300872-blycbi4u	647	1	In	in	IN
cord-300872-blycbi4u	647	2	addition	addition	NN
cord-300872-blycbi4u	647	3	,	,	,
cord-300872-blycbi4u	647	4	these	these	DT
cord-300872-blycbi4u	647	5	results	result	NNS
cord-300872-blycbi4u	647	6	highlighted	highlight	VBD
cord-300872-blycbi4u	647	7	the	the	DT
cord-300872-blycbi4u	647	8	effect	effect	NN
cord-300872-blycbi4u	647	9	of	of	IN
cord-300872-blycbi4u	647	10	the	the	DT
cord-300872-blycbi4u	647	11	chlorine	chlorine	NN
cord-300872-blycbi4u	647	12	atom	atom	NN
cord-300872-blycbi4u	647	13	at	at	IN
cord-300872-blycbi4u	647	14	position	position	NN
cord-300872-blycbi4u	647	15	5	5	CD
cord-300872-blycbi4u	647	16	of	of	IN
cord-300872-blycbi4u	647	17	the	the	DT
cord-300872-blycbi4u	647	18	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	647	19	moiety	moiety	NN
cord-300872-blycbi4u	647	20	on	on	IN
cord-300872-blycbi4u	647	21	the	the	DT
cord-300872-blycbi4u	647	22	activity	activity	NN
cord-300872-blycbi4u	647	23	compared	compare	VBN
cord-300872-blycbi4u	647	24	to	to	IN
cord-300872-blycbi4u	647	25	the	the	DT
cord-300872-blycbi4u	647	26	hydrogen	hydrogen	NN
cord-300872-blycbi4u	647	27	atom	atom	NN
cord-300872-blycbi4u	647	28	.	.	.
cord-300872-blycbi4u	648	1	The	the	DT
cord-300872-blycbi4u	648	2	chemical	chemical	NN
cord-300872-blycbi4u	648	3	references	reference	NNS
cord-300872-blycbi4u	648	4	donepezil	donepezil	NNP
cord-300872-blycbi4u	648	5	,	,	,
cord-300872-blycbi4u	648	6	tacrine	tacrine	FW
cord-300872-blycbi4u	648	7	,	,	,
cord-300872-blycbi4u	648	8	and	and	CC
cord-300872-blycbi4u	648	9	galantamine	galantamine	NNP
cord-300872-blycbi4u	648	10	exhibited	exhibit	VBD
cord-300872-blycbi4u	648	11	inhibition	inhibition	NN
cord-300872-blycbi4u	648	12	towards	towards	IN
cord-300872-blycbi4u	648	13	hBChE	hBChE	NNP
cord-300872-blycbi4u	648	14	,	,	,
cord-300872-blycbi4u	648	15	with	with	IN
cord-300872-blycbi4u	648	16	values	value	NNS
cord-300872-blycbi4u	648	17	of	of	IN
cord-300872-blycbi4u	648	18	84.3	84.3	CD
cord-300872-blycbi4u	648	19	,	,	,
cord-300872-blycbi4u	648	20	>	>	XX
cord-300872-blycbi4u	648	21	90	90	CD
cord-300872-blycbi4u	648	22	,	,	,
cord-300872-blycbi4u	648	23	and	and	CC
cord-300872-blycbi4u	648	24	65.8	65.8	CD
cord-300872-blycbi4u	648	25	%	%	NN
cord-300872-blycbi4u	648	26	,	,	,
cord-300872-blycbi4u	648	27	respectively	respectively	RB
cord-300872-blycbi4u	648	28	.	.	.
cord-300872-blycbi4u	649	1	On	on	IN
cord-300872-blycbi4u	649	2	the	the	DT
cord-300872-blycbi4u	649	3	other	other	JJ
cord-300872-blycbi4u	649	4	hand	hand	NN
cord-300872-blycbi4u	649	5	,	,	,
cord-300872-blycbi4u	649	6	the	the	DT
cord-300872-blycbi4u	649	7	inhibition	inhibition	NN
cord-300872-blycbi4u	649	8	activity	activity	NN
cord-300872-blycbi4u	649	9	of	of	IN
cord-300872-blycbi4u	649	10	compound	compound	NN
cord-300872-blycbi4u	649	11	10	10	CD
cord-300872-blycbi4u	649	12	and	and	CC
cord-300872-blycbi4u	649	13	its	-PRON-	PRP$
cord-300872-blycbi4u	649	14	derivatives	derivative	NNS
cord-300872-blycbi4u	649	15	towards	towards	IN
cord-300872-blycbi4u	649	16	the	the	DT
cord-300872-blycbi4u	649	17	Aβ	Aβ	NNP
cord-300872-blycbi4u	649	18	42	42	CD
cord-300872-blycbi4u	649	19	antiaggregating	antiaggregating	NN
cord-300872-blycbi4u	649	20	property	property	NN
cord-300872-blycbi4u	649	21	was	be	VBD
cord-300872-blycbi4u	649	22	evaluated	evaluate	VBN
cord-300872-blycbi4u	649	23	.	.	.
cord-300872-blycbi4u	650	1	The	the	DT
cord-300872-blycbi4u	650	2	obtained	obtain	VBN
cord-300872-blycbi4u	650	3	results	result	NNS
cord-300872-blycbi4u	650	4	demonstrated	demonstrate	VBD
cord-300872-blycbi4u	650	5	that	that	IN
cord-300872-blycbi4u	650	6	the	the	DT
cord-300872-blycbi4u	650	7	inhibition	inhibition	NN
cord-300872-blycbi4u	650	8	potencies	potency	NNS
cord-300872-blycbi4u	650	9	of	of	IN
cord-300872-blycbi4u	650	10	all	all	DT
cord-300872-blycbi4u	650	11	derivatives	derivative	NNS
cord-300872-blycbi4u	650	12	ranged	range	VBD
cord-300872-blycbi4u	650	13	from	from	IN
cord-300872-blycbi4u	650	14	19.1	19.1	CD
cord-300872-blycbi4u	650	15	to	to	IN
cord-300872-blycbi4u	650	16	65.0	65.0	CD
cord-300872-blycbi4u	650	17	%	%	NN
cord-300872-blycbi4u	650	18	at	at	IN
cord-300872-blycbi4u	650	19	the	the	DT
cord-300872-blycbi4u	650	20	concentration	concentration	NN
cord-300872-blycbi4u	650	21	of	of	IN
cord-300872-blycbi4u	650	22	50	50	CD
cord-300872-blycbi4u	650	23	mM	mm	CD
cord-300872-blycbi4u	650	24	;	;	:
cord-300872-blycbi4u	650	25	both	both	DT
cord-300872-blycbi4u	650	26	series	series	NN
cord-300872-blycbi4u	650	27	(	(	-LRB-
cord-300872-blycbi4u	650	28	X	x	NN
cord-300872-blycbi4u	650	29	=	=	NN
cord-300872-blycbi4u	650	30	H	H	NNP
cord-300872-blycbi4u	650	31	,	,	,
cord-300872-blycbi4u	650	32	Cl	Cl	NNP
cord-300872-blycbi4u	650	33	)	)	-RRB-
cord-300872-blycbi4u	650	34	had	have	VBD
cord-300872-blycbi4u	650	35	close	close	JJ
cord-300872-blycbi4u	650	36	activity	activity	NN
cord-300872-blycbi4u	650	37	rates	rate	NNS
cord-300872-blycbi4u	650	38	.	.	.
cord-300872-blycbi4u	651	1	In	in	IN
cord-300872-blycbi4u	651	2	addition	addition	NN
cord-300872-blycbi4u	651	3	,	,	,
cord-300872-blycbi4u	651	4	the	the	DT
cord-300872-blycbi4u	651	5	metal	metal	NN
cord-300872-blycbi4u	651	6	chelating	chelating	NN
cord-300872-blycbi4u	651	7	ability	ability	NN
cord-300872-blycbi4u	651	8	of	of	IN
cord-300872-blycbi4u	651	9	the	the	DT
cord-300872-blycbi4u	651	10	selected	select	VBN
cord-300872-blycbi4u	651	11	compounds	compound	NNS
cord-300872-blycbi4u	651	12	was	be	VBD
cord-300872-blycbi4u	651	13	examined	examine	VBN
cord-300872-blycbi4u	651	14	using	use	VBG
cord-300872-blycbi4u	651	15	Cu	Cu	NNP
cord-300872-blycbi4u	651	16	2	2	CD
cord-300872-blycbi4u	651	17	+	+	SYM
cord-300872-blycbi4u	651	18	and	and	CC
cord-300872-blycbi4u	651	19	Zn	Zn	NNP
cord-300872-blycbi4u	651	20	2	2	CD
cord-300872-blycbi4u	651	21	+	+	CC
cord-300872-blycbi4u	651	22	in	in	IN
cord-300872-blycbi4u	651	23	phosphate	phosphate	NN
cord-300872-blycbi4u	651	24	buffer	buffer	NN
cord-300872-blycbi4u	651	25	solution	solution	NN
cord-300872-blycbi4u	651	26	(	(	-LRB-
cord-300872-blycbi4u	651	27	pH	pH	NNP
cord-300872-blycbi4u	651	28	7.4	7.4	CD
cord-300872-blycbi4u	651	29	)	)	-RRB-
cord-300872-blycbi4u	651	30	.	.	.
cord-300872-blycbi4u	652	1	Spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	652	2	data	datum	NNS
cord-300872-blycbi4u	652	3	showed	show	VBD
cord-300872-blycbi4u	652	4	that	that	IN
cord-300872-blycbi4u	652	5	there	there	EX
cord-300872-blycbi4u	652	6	is	be	VBZ
cord-300872-blycbi4u	652	7	a	a	DT
cord-300872-blycbi4u	652	8	bathochromic	bathochromic	JJ
cord-300872-blycbi4u	652	9	shift	shift	NN
cord-300872-blycbi4u	652	10	of	of	IN
cord-300872-blycbi4u	652	11	about	about	RB
cord-300872-blycbi4u	652	12	18	18	CD
cord-300872-blycbi4u	652	13	nm	nm	RB
cord-300872-blycbi4u	652	14	from	from	IN
cord-300872-blycbi4u	652	15	the	the	DT
cord-300872-blycbi4u	652	16	original	original	JJ
cord-300872-blycbi4u	652	17	band	band	NN
cord-300872-blycbi4u	652	18	(	(	-LRB-
cord-300872-blycbi4u	652	19	243	243	CD
cord-300872-blycbi4u	652	20	nm	nm	CD
cord-300872-blycbi4u	652	21	)	)	-RRB-
cord-300872-blycbi4u	652	22	upon	upon	IN
cord-300872-blycbi4u	652	23	complex	complex	JJ
cord-300872-blycbi4u	652	24	formation	formation	NN
cord-300872-blycbi4u	652	25	;	;	:
cord-300872-blycbi4u	652	26	as	as	IN
cord-300872-blycbi4u	652	27	the	the	DT
cord-300872-blycbi4u	652	28	metal	metal	NN
cord-300872-blycbi4u	652	29	ion	ion	NN
cord-300872-blycbi4u	652	30	concentration	concentration	NN
cord-300872-blycbi4u	652	31	increases	increase	NNS
cord-300872-blycbi4u	652	32	(	(	-LRB-
cord-300872-blycbi4u	652	33	1.56	1.56	CD
cord-300872-blycbi4u	652	34	to	to	IN
cord-300872-blycbi4u	652	35	50	50	CD
cord-300872-blycbi4u	652	36	mM	mm	CD
cord-300872-blycbi4u	652	37	)	)	-RRB-
cord-300872-blycbi4u	652	38	,	,	,
cord-300872-blycbi4u	652	39	the	the	DT
cord-300872-blycbi4u	652	40	intensity	intensity	NN
cord-300872-blycbi4u	652	41	of	of	IN
cord-300872-blycbi4u	652	42	the	the	DT
cord-300872-blycbi4u	652	43	absorption	absorption	NN
cord-300872-blycbi4u	652	44	band	band	NN
cord-300872-blycbi4u	652	45	also	also	RB
cord-300872-blycbi4u	652	46	increases	increase	VBZ
cord-300872-blycbi4u	652	47	.	.	.
cord-300872-blycbi4u	653	1	Finally	finally	RB
cord-300872-blycbi4u	653	2	,	,	,
cord-300872-blycbi4u	653	3	all	all	DT
cord-300872-blycbi4u	653	4	derivatives	derivative	NNS
cord-300872-blycbi4u	653	5	showed	show	VBD
cord-300872-blycbi4u	653	6	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	653	7	activity	activity	NN
cord-300872-blycbi4u	653	8	,	,	,
cord-300872-blycbi4u	653	9	whereby	whereby	WRB
cord-300872-blycbi4u	653	10	some	some	DT
cord-300872-blycbi4u	653	11	prepared	prepared	JJ
cord-300872-blycbi4u	653	12	compounds	compound	NNS
cord-300872-blycbi4u	653	13	exhibited	exhibit	VBD
cord-300872-blycbi4u	653	14	higher	high	JJR
cord-300872-blycbi4u	653	15	activity	activity	NN
cord-300872-blycbi4u	653	16	than	than	IN
cord-300872-blycbi4u	653	17	Trolox	Trolox	NNP
cord-300872-blycbi4u	653	18	.	.	.
cord-300872-blycbi4u	654	1	Raj	Raj	NNP
cord-300872-blycbi4u	654	2	and	and	CC
cord-300872-blycbi4u	654	3	Padhi	Padhi	NNP
cord-300872-blycbi4u	654	4	reported	report	VBD
cord-300872-blycbi4u	654	5	that	that	IN
cord-300872-blycbi4u	654	6	the	the	DT
cord-300872-blycbi4u	654	7	condensation	condensation	NN
cord-300872-blycbi4u	654	8	of	of	IN
cord-300872-blycbi4u	654	9	8-hydroxyquinoline-2-carbaldehyde	8-hydroxyquinoline-2-carbaldehyde	CD
cord-300872-blycbi4u	654	10	(	(	-LRB-
cord-300872-blycbi4u	654	11	95	95	CD
cord-300872-blycbi4u	654	12	)	)	-RRB-
cord-300872-blycbi4u	654	13	with	with	IN
cord-300872-blycbi4u	654	14	aromatic	aromatic	JJ
cord-300872-blycbi4u	654	15	diamines	diamine	NNS
cord-300872-blycbi4u	654	16	(	(	-LRB-
cord-300872-blycbi4u	654	17	96	96	CD
cord-300872-blycbi4u	654	18	)	)	-RRB-
cord-300872-blycbi4u	654	19	afforded	afford	VBN
cord-300872-blycbi4u	654	20	quinoline	quinoline	NN
cord-300872-blycbi4u	654	21	-	-	HYPH
cord-300872-blycbi4u	654	22	based	base	VBN
cord-300872-blycbi4u	654	23	benzimidazole	benzimidazole	NNP
cord-300872-blycbi4u	654	24	(	(	-LRB-
cord-300872-blycbi4u	654	25	97	97	CD
cord-300872-blycbi4u	654	26	)	)	-RRB-
cord-300872-blycbi4u	654	27	followed	follow	VBN
cord-300872-blycbi4u	654	28	by	by	IN
cord-300872-blycbi4u	654	29	intracyclization	intracyclization	NN
cord-300872-blycbi4u	654	30	reaction	reaction	NN
cord-300872-blycbi4u	654	31	to	to	TO
cord-300872-blycbi4u	654	32	produce	produce	VB
cord-300872-blycbi4u	654	33	derivatives	derivative	NNS
cord-300872-blycbi4u	654	34	of	of	IN
cord-300872-blycbi4u	654	35	100	100	CD
cord-300872-blycbi4u	654	36	.	.	.
cord-300872-blycbi4u	655	1	With	with	IN
cord-300872-blycbi4u	655	2	aliphatic	aliphatic	JJ
cord-300872-blycbi4u	655	3	diamines	diamine	NNS
cord-300872-blycbi4u	655	4	(	(	-LRB-
cord-300872-blycbi4u	655	5	98	98	CD
cord-300872-blycbi4u	655	6	)	)	-RRB-
cord-300872-blycbi4u	655	7	,	,	,
cord-300872-blycbi4u	655	8	compound	compound	NN
cord-300872-blycbi4u	655	9	95	95	CD
cord-300872-blycbi4u	655	10	produced	produce	VBN
cord-300872-blycbi4u	655	11	bis	bis	NNP
cord-300872-blycbi4u	655	12	-	-	HYPH
cord-300872-blycbi4u	655	13	imines	imine	NNS
cord-300872-blycbi4u	655	14	(	(	-LRB-
cord-300872-blycbi4u	655	15	99	99	CD
cord-300872-blycbi4u	655	16	)	)	-RRB-
cord-300872-blycbi4u	655	17	without	without	IN
cord-300872-blycbi4u	655	18	undergoing	undergo	VBG
cord-300872-blycbi4u	655	19	intracyclization	intracyclization	NN
cord-300872-blycbi4u	655	20	reaction	reaction	NN
cord-300872-blycbi4u	655	21	,	,	,
cord-300872-blycbi4u	655	22	as	as	IN
cord-300872-blycbi4u	655	23	shown	show	VBN
cord-300872-blycbi4u	655	24	in	in	IN
cord-300872-blycbi4u	655	25	Scheme	scheme	NN
cord-300872-blycbi4u	655	26	23	23	CD
cord-300872-blycbi4u	655	27	[	[	-LRB-
cord-300872-blycbi4u	655	28	64	64	CD
cord-300872-blycbi4u	655	29	]	]	-RRB-
cord-300872-blycbi4u	655	30	.	.	.
cord-300872-blycbi4u	656	1	Products	product	NNS
cord-300872-blycbi4u	656	2	of	of	IN
cord-300872-blycbi4u	656	3	these	these	DT
cord-300872-blycbi4u	656	4	reactions	reaction	NNS
cord-300872-blycbi4u	656	5	have	have	VBP
cord-300872-blycbi4u	656	6	been	be	VBN
cord-300872-blycbi4u	656	7	well	well	RB
cord-300872-blycbi4u	656	8	-	-	HYPH
cord-300872-blycbi4u	656	9	characterized	characterize	VBN
cord-300872-blycbi4u	656	10	using	use	VBG
cord-300872-blycbi4u	656	11	various	various	JJ
cord-300872-blycbi4u	656	12	techniques	technique	NNS
cord-300872-blycbi4u	656	13	,	,	,
cord-300872-blycbi4u	656	14	including	include	VBG
cord-300872-blycbi4u	656	15	FT	FT	NNP
cord-300872-blycbi4u	656	16	-	-	HYPH
cord-300872-blycbi4u	656	17	IR	IR	NNP
cord-300872-blycbi4u	656	18	,	,	,
cord-300872-blycbi4u	656	19	NMR	NMR	NNP
cord-300872-blycbi4u	656	20	,	,	,
cord-300872-blycbi4u	656	21	MS	MS	NNP
cord-300872-blycbi4u	656	22	,	,	,
cord-300872-blycbi4u	656	23	and	and	CC
cord-300872-blycbi4u	656	24	single	single	JJ
cord-300872-blycbi4u	656	25	-	-	HYPH
cord-300872-blycbi4u	656	26	crystal	crystal	NN
cord-300872-blycbi4u	656	27	X	x	NN
cord-300872-blycbi4u	656	28	-	-	NN
cord-300872-blycbi4u	656	29	ray	ray	NN
cord-300872-blycbi4u	656	30	diffraction	diffraction	NN
cord-300872-blycbi4u	656	31	method	method	NN
cord-300872-blycbi4u	656	32	.	.	.
cord-300872-blycbi4u	657	1	In	in	IN
cord-300872-blycbi4u	657	2	the	the	DT
cord-300872-blycbi4u	657	3	first	first	JJ
cord-300872-blycbi4u	657	4	step	step	NN
cord-300872-blycbi4u	657	5	of	of	IN
cord-300872-blycbi4u	657	6	both	both	DT
cord-300872-blycbi4u	657	7	reactions	reaction	NNS
cord-300872-blycbi4u	657	8	,	,	,
cord-300872-blycbi4u	657	9	one	one	CD
cord-300872-blycbi4u	657	10	equivalent	equivalent	NN
cord-300872-blycbi4u	657	11	of	of	IN
cord-300872-blycbi4u	657	12	8-hydroxyquinoline-2-carbaldehyde	8-hydroxyquinoline-2-carbaldehyde	CD
cord-300872-blycbi4u	657	13	underwent	undergo	VBD
cord-300872-blycbi4u	657	14	a	a	DT
cord-300872-blycbi4u	657	15	condensation	condensation	NN
cord-300872-blycbi4u	657	16	reaction	reaction	NN
cord-300872-blycbi4u	657	17	with	with	IN
cord-300872-blycbi4u	657	18	one	one	CD
cord-300872-blycbi4u	657	19	equivalent	equivalent	NN
cord-300872-blycbi4u	657	20	of	of	IN
cord-300872-blycbi4u	657	21	primary	primary	JJ
cord-300872-blycbi4u	657	22	amine	amine	NN
cord-300872-blycbi4u	657	23	to	to	TO
cord-300872-blycbi4u	657	24	form	form	VB
cord-300872-blycbi4u	657	25	the	the	DT
cord-300872-blycbi4u	657	26	mono	mono	NN
cord-300872-blycbi4u	657	27	-	-	HYPH
cord-300872-blycbi4u	657	28	imine	imine	NN
cord-300872-blycbi4u	657	29	product	product	NN
cord-300872-blycbi4u	657	30	(	(	-LRB-
cord-300872-blycbi4u	657	31	Schiff	Schiff	NNP
cord-300872-blycbi4u	657	32	bases	basis	NNS
cord-300872-blycbi4u	657	33	)	)	-RRB-
cord-300872-blycbi4u	657	34	.	.	.
cord-300872-blycbi4u	658	1	However	however	RB
cord-300872-blycbi4u	658	2	,	,	,
cord-300872-blycbi4u	658	3	in	in	IN
cord-300872-blycbi4u	658	4	the	the	DT
cord-300872-blycbi4u	658	5	second	second	JJ
cord-300872-blycbi4u	658	6	step	step	NN
cord-300872-blycbi4u	658	7	and	and	CC
cord-300872-blycbi4u	658	8	with	with	IN
cord-300872-blycbi4u	658	9	the	the	DT
cord-300872-blycbi4u	658	10	presence	presence	NN
cord-300872-blycbi4u	658	11	of	of	IN
cord-300872-blycbi4u	658	12	aromatic	aromatic	JJ
cord-300872-blycbi4u	658	13	amine	amine	NN
cord-300872-blycbi4u	658	14	,	,	,
cord-300872-blycbi4u	658	15	an	an	DT
cord-300872-blycbi4u	658	16	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	658	17	ring	ring	NN
cord-300872-blycbi4u	658	18	cyclization	cyclization	NN
cord-300872-blycbi4u	658	19	occurred	occur	VBD
cord-300872-blycbi4u	658	20	,	,	,
cord-300872-blycbi4u	658	21	where	where	WRB
cord-300872-blycbi4u	658	22	the	the	DT
cord-300872-blycbi4u	658	23	resulting	result	VBG
cord-300872-blycbi4u	658	24	precursor	precursor	NN
cord-300872-blycbi4u	658	25	reacts	react	VBZ
cord-300872-blycbi4u	658	26	further	further	RB
cord-300872-blycbi4u	658	27	with	with	IN
cord-300872-blycbi4u	658	28	the	the	DT
cord-300872-blycbi4u	658	29	second	second	JJ
cord-300872-blycbi4u	658	30	equivalent	equivalent	NN
cord-300872-blycbi4u	658	31	of	of	IN
cord-300872-blycbi4u	658	32	8-hydroxyquinoline-2-carbaldehyde	8-hydroxyquinoline-2-carbaldehyde	CD
cord-300872-blycbi4u	658	33	,	,	,
cord-300872-blycbi4u	658	34	followed	follow	VBN
cord-300872-blycbi4u	658	35	by	by	IN
cord-300872-blycbi4u	658	36	migration	migration	NN
cord-300872-blycbi4u	658	37	of	of	IN
cord-300872-blycbi4u	658	38	hydride	hydride	NN
cord-300872-blycbi4u	658	39	to	to	TO
cord-300872-blycbi4u	658	40	afford	afford	VB
cord-300872-blycbi4u	658	41	compound	compound	NN
cord-300872-blycbi4u	658	42	100	100	CD
cord-300872-blycbi4u	658	43	.	.	.
cord-300872-blycbi4u	659	1	In	in	IN
cord-300872-blycbi4u	659	2	the	the	DT
cord-300872-blycbi4u	659	3	case	case	NN
cord-300872-blycbi4u	659	4	of	of	IN
cord-300872-blycbi4u	659	5	an	an	DT
cord-300872-blycbi4u	659	6	aliphatic	aliphatic	JJ
cord-300872-blycbi4u	659	7	amine	amine	NN
cord-300872-blycbi4u	659	8	,	,	,
cord-300872-blycbi4u	659	9	the	the	DT
cord-300872-blycbi4u	659	10	second	second	JJ
cord-300872-blycbi4u	659	11	step	step	NN
cord-300872-blycbi4u	659	12	represents	represent	VBZ
cord-300872-blycbi4u	659	13	a	a	DT
cord-300872-blycbi4u	659	14	second	second	JJ
cord-300872-blycbi4u	659	15	condensation	condensation	NN
cord-300872-blycbi4u	659	16	reaction	reaction	NN
cord-300872-blycbi4u	659	17	with	with	IN
cord-300872-blycbi4u	659	18	another	another	DT
cord-300872-blycbi4u	659	19	molecule	molecule	NN
cord-300872-blycbi4u	659	20	of	of	IN
cord-300872-blycbi4u	659	21	8-hydroxyquinoline-2-carbaldehyde	8-hydroxyquinoline-2-carbaldehyde	CD
cord-300872-blycbi4u	659	22	to	to	TO
cord-300872-blycbi4u	659	23	give	give	VB
cord-300872-blycbi4u	659	24	the	the	DT
cord-300872-blycbi4u	659	25	final	final	JJ
cord-300872-blycbi4u	659	26	product	product	NN
cord-300872-blycbi4u	659	27	99	99	CD
cord-300872-blycbi4u	659	28	.	.	.
cord-300872-blycbi4u	660	1	In	in	IN
cord-300872-blycbi4u	660	2	a	a	DT
cord-300872-blycbi4u	660	3	recent	recent	JJ
cord-300872-blycbi4u	660	4	publication	publication	NN
cord-300872-blycbi4u	660	5	,	,	,
cord-300872-blycbi4u	660	6	Prati	Prati	NNP
cord-300872-blycbi4u	660	7	and	and	CC
cord-300872-blycbi4u	660	8	coworkers	coworker	NNS
cord-300872-blycbi4u	660	9	[	[	-LRB-
cord-300872-blycbi4u	660	10	63	63	CD
cord-300872-blycbi4u	660	11	]	]	-RRB-
cord-300872-blycbi4u	660	12	described	describe	VBD
cord-300872-blycbi4u	660	13	the	the	DT
cord-300872-blycbi4u	660	14	synthesis	synthesis	NN
cord-300872-blycbi4u	660	15	of	of	IN
cord-300872-blycbi4u	660	16	a	a	DT
cord-300872-blycbi4u	660	17	new	new	JJ
cord-300872-blycbi4u	660	18	series	series	NN
cord-300872-blycbi4u	660	19	of	of	IN
cord-300872-blycbi4u	660	20	8hydroxyquinoline	8hydroxyquinoline	CD
cord-300872-blycbi4u	660	21	derivatives	derivative	NNS
cord-300872-blycbi4u	660	22	(	(	-LRB-
cord-300872-blycbi4u	660	23	94	94	CD
cord-300872-blycbi4u	660	24	)	)	-RRB-
cord-300872-blycbi4u	660	25	for	for	IN
cord-300872-blycbi4u	660	26	which	which	WDT
cord-300872-blycbi4u	660	27	the	the	DT
cord-300872-blycbi4u	660	28	products	product	NNS
cord-300872-blycbi4u	660	29	possess	possess	VBP
cord-300872-blycbi4u	660	30	structural	structural	JJ
cord-300872-blycbi4u	660	31	features	feature	NNS
cord-300872-blycbi4u	660	32	of	of	IN
cord-300872-blycbi4u	660	33	two	two	CD
cord-300872-blycbi4u	660	34	commercial	commercial	JJ
cord-300872-blycbi4u	660	35	drugs	drug	NNS
cord-300872-blycbi4u	660	36	,	,	,
cord-300872-blycbi4u	660	37	namely	namely	RB
cord-300872-blycbi4u	660	38	donepezil	donepezil	NNP
cord-300872-blycbi4u	660	39	and	and	CC
cord-300872-blycbi4u	660	40	clioquinol	clioquinol	NNP
cord-300872-blycbi4u	660	41	.	.	.
cord-300872-blycbi4u	661	1	Depicted	depict	VBN
cord-300872-blycbi4u	661	2	in	in	IN
cord-300872-blycbi4u	661	3	Scheme	Scheme	NNP
cord-300872-blycbi4u	661	4	22	22	CD
cord-300872-blycbi4u	661	5	are	be	VBP
cord-300872-blycbi4u	661	6	the	the	DT
cord-300872-blycbi4u	661	7	steps	step	NNS
cord-300872-blycbi4u	661	8	involved	involve	VBN
cord-300872-blycbi4u	661	9	in	in	IN
cord-300872-blycbi4u	661	10	the	the	DT
cord-300872-blycbi4u	661	11	synthesis	synthesis	NN
cord-300872-blycbi4u	661	12	of	of	IN
cord-300872-blycbi4u	661	13	these	these	DT
cord-300872-blycbi4u	661	14	compounds	compound	NNS
cord-300872-blycbi4u	661	15	.	.	.
cord-300872-blycbi4u	662	1	This	this	DT
cord-300872-blycbi4u	662	2	synthesis	synthesis	NN
cord-300872-blycbi4u	662	3	was	be	VBD
cord-300872-blycbi4u	662	4	a	a	DT
cord-300872-blycbi4u	662	5	multicomponent	multicomponent	JJ
cord-300872-blycbi4u	662	6	Mannich	Mannich	NNP
cord-300872-blycbi4u	662	7	reaction	reaction	NN
cord-300872-blycbi4u	662	8	that	that	WDT
cord-300872-blycbi4u	662	9	involved	involve	VBD
cord-300872-blycbi4u	662	10	a	a	DT
cord-300872-blycbi4u	662	11	mixture	mixture	NN
cord-300872-blycbi4u	662	12	containing	contain	VBG
cord-300872-blycbi4u	662	13	piperazine	piperazine	NN
cord-300872-blycbi4u	662	14	(	(	-LRB-
cord-300872-blycbi4u	662	15	92	92	CD
cord-300872-blycbi4u	662	16	)	)	-RRB-
cord-300872-blycbi4u	662	17	,	,	,
cord-300872-blycbi4u	662	18	paraformaldehyde	paraformaldehyde	NNP
cord-300872-blycbi4u	662	19	,	,	,
cord-300872-blycbi4u	662	20	and	and	CC
cord-300872-blycbi4u	662	21	8-HQ	8-hq	CD
cord-300872-blycbi4u	662	22	or	or	CC
cord-300872-blycbi4u	662	23	its	-PRON-	PRP$
cord-300872-blycbi4u	662	24	5-chloroanalogue	5-chloroanalogue	CD
cord-300872-blycbi4u	662	25	under	under	IN
cord-300872-blycbi4u	662	26	a	a	DT
cord-300872-blycbi4u	662	27	microwave	microwave	NN
cord-300872-blycbi4u	662	28	-	-	HYPH
cord-300872-blycbi4u	662	29	assisted	assist	VBN
cord-300872-blycbi4u	662	30	procedure	procedure	NN
cord-300872-blycbi4u	662	31	to	to	TO
cord-300872-blycbi4u	662	32	afford	afford	VB
cord-300872-blycbi4u	662	33	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	7-(piperazin-1-ylmethyl)-8-hydroxyquinolines	CD
cord-300872-blycbi4u	662	34	(	(	-LRB-
cord-300872-blycbi4u	662	35	93	93	CD
cord-300872-blycbi4u	662	36	)	)	-RRB-
cord-300872-blycbi4u	662	37	.	.	.
cord-300872-blycbi4u	663	1	This	this	DT
cord-300872-blycbi4u	663	2	synthon	synthon	NN
cord-300872-blycbi4u	663	3	was	be	VBD
cord-300872-blycbi4u	663	4	then	then	RB
cord-300872-blycbi4u	663	5	reacted	react	VBN
cord-300872-blycbi4u	663	6	with	with	IN
cord-300872-blycbi4u	663	7	various	various	JJ
cord-300872-blycbi4u	663	8	benzyl	benzyl	NN
cord-300872-blycbi4u	663	9	chlorides	chloride	NNS
cord-300872-blycbi4u	663	10	in	in	IN
cord-300872-blycbi4u	663	11	DMF	DMF	NNP
cord-300872-blycbi4u	663	12	.	.	.
cord-300872-blycbi4u	664	1	Compound	compound	NN
cord-300872-blycbi4u	664	2	94	94	CD
cord-300872-blycbi4u	664	3	and	and	CC
cord-300872-blycbi4u	664	4	its	-PRON-	PRP$
cord-300872-blycbi4u	664	5	derivatives	derivative	NNS
cord-300872-blycbi4u	664	6	were	be	VBD
cord-300872-blycbi4u	664	7	assayed	assay	VBN
cord-300872-blycbi4u	664	8	for	for	IN
cord-300872-blycbi4u	664	9	potential	potential	JJ
cord-300872-blycbi4u	664	10	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	664	11	activity	activity	NN
cord-300872-blycbi4u	664	12	towards	towards	IN
cord-300872-blycbi4u	664	13	human	human	JJ
cord-300872-blycbi4u	664	14	anti	anti	JJ
cord-300872-blycbi4u	664	15	-	-	JJ
cord-300872-blycbi4u	664	16	hAChE	hache	JJ
cord-300872-blycbi4u	664	17	and	and	CC
cord-300872-blycbi4u	664	18	anti	anti	NNS
cord-300872-blycbi4u	664	19	-	-	NN
cord-300872-blycbi4u	664	20	hBChE.	hbche.	XX
cord-300872-blycbi4u	665	1	The	the	DT
cord-300872-blycbi4u	665	2	results	result	NNS
cord-300872-blycbi4u	665	3	indicated	indicate	VBD
cord-300872-blycbi4u	665	4	that	that	IN
cord-300872-blycbi4u	665	5	at	at	IN
cord-300872-blycbi4u	665	6	a	a	DT
cord-300872-blycbi4u	665	7	concentration	concentration	NN
cord-300872-blycbi4u	665	8	of	of	IN
cord-300872-blycbi4u	665	9	40	40	CD
cord-300872-blycbi4u	665	10	mM	mm	CD
cord-300872-blycbi4u	665	11	,	,	,
cord-300872-blycbi4u	665	12	all	all	DT
cord-300872-blycbi4u	665	13	derivatives	derivative	NNS
cord-300872-blycbi4u	665	14	exhibited	exhibit	VBD
cord-300872-blycbi4u	665	15	inhibition	inhibition	NN
cord-300872-blycbi4u	665	16	,	,	,
cord-300872-blycbi4u	665	17	with	with	IN
cord-300872-blycbi4u	665	18	values	value	NNS
cord-300872-blycbi4u	665	19	ranging	range	VBG
cord-300872-blycbi4u	665	20	from	from	IN
cord-300872-blycbi4u	665	21	9.0	9.0	CD
cord-300872-blycbi4u	665	22	to	to	IN
cord-300872-blycbi4u	665	23	63.8	63.8	CD
cord-300872-blycbi4u	665	24	%	%	NN
cord-300872-blycbi4u	665	25	and	and	CC
cord-300872-blycbi4u	665	26	49.2	49.2	CD
cord-300872-blycbi4u	665	27	to	to	IN
cord-300872-blycbi4u	665	28	89.1	89.1	CD
cord-300872-blycbi4u	665	29	%	%	NN
cord-300872-blycbi4u	665	30	for	for	IN
cord-300872-blycbi4u	665	31	5-chloro-8-hydroxyquinoline	5-chloro-8-hydroxyquinoline	CD
cord-300872-blycbi4u	665	32	and	and	CC
cord-300872-blycbi4u	665	33	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	665	34	derivatives	derivative	NNS
cord-300872-blycbi4u	665	35	,	,	,
cord-300872-blycbi4u	665	36	respectively	respectively	RB
cord-300872-blycbi4u	665	37	,	,	,
cord-300872-blycbi4u	665	38	against	against	IN
cord-300872-blycbi4u	665	39	hBChE.	hbche.	XX
cord-300872-blycbi4u	666	1	However	however	RB
cord-300872-blycbi4u	666	2	,	,	,
cord-300872-blycbi4u	666	3	these	these	DT
cord-300872-blycbi4u	666	4	compounds	compound	NNS
cord-300872-blycbi4u	666	5	were	be	VBD
cord-300872-blycbi4u	666	6	inactive	inactive	JJ
cord-300872-blycbi4u	666	7	or	or	CC
cord-300872-blycbi4u	666	8	showed	show	VBD
cord-300872-blycbi4u	666	9	very	very	RB
cord-300872-blycbi4u	666	10	weak	weak	JJ
cord-300872-blycbi4u	666	11	inhibition	inhibition	NN
cord-300872-blycbi4u	666	12	activity	activity	NN
cord-300872-blycbi4u	666	13	against	against	IN
cord-300872-blycbi4u	666	14	hAChE	hAChE	NNP
cord-300872-blycbi4u	666	15	,	,	,
cord-300872-blycbi4u	666	16	suggesting	suggest	VBG
cord-300872-blycbi4u	666	17	selectivity	selectivity	NN
cord-300872-blycbi4u	666	18	of	of	IN
cord-300872-blycbi4u	666	19	the	the	DT
cord-300872-blycbi4u	666	20	target	target	NN
cord-300872-blycbi4u	666	21	products	product	NNS
cord-300872-blycbi4u	666	22	towards	towards	IN
cord-300872-blycbi4u	666	23	hBChE.	hbche.	XX
cord-300872-blycbi4u	667	1	In	in	IN
cord-300872-blycbi4u	667	2	addition	addition	NN
cord-300872-blycbi4u	667	3	,	,	,
cord-300872-blycbi4u	667	4	these	these	DT
cord-300872-blycbi4u	667	5	results	result	NNS
cord-300872-blycbi4u	667	6	highlighted	highlight	VBD
cord-300872-blycbi4u	667	7	the	the	DT
cord-300872-blycbi4u	667	8	effect	effect	NN
cord-300872-blycbi4u	667	9	of	of	IN
cord-300872-blycbi4u	667	10	the	the	DT
cord-300872-blycbi4u	667	11	chlorine	chlorine	NN
cord-300872-blycbi4u	667	12	atom	atom	NN
cord-300872-blycbi4u	667	13	at	at	IN
cord-300872-blycbi4u	667	14	position	position	NN
cord-300872-blycbi4u	667	15	5	5	CD
cord-300872-blycbi4u	667	16	of	of	IN
cord-300872-blycbi4u	667	17	the	the	DT
cord-300872-blycbi4u	667	18	8hydroxyquinoline	8hydroxyquinoline	CD
cord-300872-blycbi4u	667	19	moiety	moiety	NN
cord-300872-blycbi4u	667	20	on	on	IN
cord-300872-blycbi4u	667	21	the	the	DT
cord-300872-blycbi4u	667	22	activity	activity	NN
cord-300872-blycbi4u	667	23	compared	compare	VBN
cord-300872-blycbi4u	667	24	to	to	IN
cord-300872-blycbi4u	667	25	the	the	DT
cord-300872-blycbi4u	667	26	hydrogen	hydrogen	NN
cord-300872-blycbi4u	667	27	atom	atom	NN
cord-300872-blycbi4u	667	28	.	.	.
cord-300872-blycbi4u	668	1	The	the	DT
cord-300872-blycbi4u	668	2	chemical	chemical	NN
cord-300872-blycbi4u	668	3	references	reference	NNS
cord-300872-blycbi4u	668	4	Scheme	Scheme	NNP
cord-300872-blycbi4u	668	5	23	23	CD
cord-300872-blycbi4u	668	6	.	.	.
cord-300872-blycbi4u	669	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	669	2	of	of	IN
cord-300872-blycbi4u	669	3	new	new	JJ
cord-300872-blycbi4u	669	4	derivatives	derivative	NNS
cord-300872-blycbi4u	669	5	of	of	IN
cord-300872-blycbi4u	669	6	8-hydroxyquinolie	8-hydroxyquinolie	CD
cord-300872-blycbi4u	669	7	-	-	HYPH
cord-300872-blycbi4u	669	8	based	base	VBN
cord-300872-blycbi4u	669	9	benzimidazole	benzimidazole	NN
cord-300872-blycbi4u	669	10	.	.	.
cord-300872-blycbi4u	670	1	On	on	IN
cord-300872-blycbi4u	670	2	the	the	DT
cord-300872-blycbi4u	670	3	other	other	JJ
cord-300872-blycbi4u	670	4	hand	hand	NN
cord-300872-blycbi4u	670	5	,	,	,
cord-300872-blycbi4u	670	6	Kong	Kong	NNP
cord-300872-blycbi4u	670	7	et	et	NNP
cord-300872-blycbi4u	670	8	al	al	NNP
cord-300872-blycbi4u	670	9	.	.	.
cord-300872-blycbi4u	671	1	(	(	-LRB-
cord-300872-blycbi4u	671	2	2017	2017	CD
cord-300872-blycbi4u	671	3	)	)	-RRB-
cord-300872-blycbi4u	671	4	prepared	prepared	JJ
cord-300872-blycbi4u	671	5	novel	novel	JJ
cord-300872-blycbi4u	671	6	barbituroquinoline	barbituroquinoline	NN
cord-300872-blycbi4u	671	7	derivatives	derivative	NNS
cord-300872-blycbi4u	671	8	106	106	CD
cord-300872-blycbi4u	671	9	and	and	CC
cord-300872-blycbi4u	671	10	107	107	CD
cord-300872-blycbi4u	671	11	in	in	IN
cord-300872-blycbi4u	671	12	a	a	DT
cord-300872-blycbi4u	671	13	one	one	CD
cord-300872-blycbi4u	671	14	-	-	HYPH
cord-300872-blycbi4u	671	15	pot	pot	NN
cord-300872-blycbi4u	671	16	procedure	procedure	NN
cord-300872-blycbi4u	671	17	by	by	IN
cord-300872-blycbi4u	671	18	combining	combine	VBG
cord-300872-blycbi4u	671	19	three	three	CD
cord-300872-blycbi4u	671	20	components	component	NNS
cord-300872-blycbi4u	671	21	in	in	IN
cord-300872-blycbi4u	671	22	water	water	NN
cord-300872-blycbi4u	671	23	,	,	,
cord-300872-blycbi4u	671	24	namely	namely	RB
cord-300872-blycbi4u	671	25	1	1	CD
cord-300872-blycbi4u	671	26	,	,	,
cord-300872-blycbi4u	671	27	2-thiobarbituric	2-thiobarbituric	CD
cord-300872-blycbi4u	671	28	acid	acid	NN
cord-300872-blycbi4u	671	29	(	(	-LRB-
cord-300872-blycbi4u	671	30	104	104	CD
cord-300872-blycbi4u	671	31	)	)	-RRB-
cord-300872-blycbi4u	671	32	,	,	,
cord-300872-blycbi4u	671	33	and	and	CC
cord-300872-blycbi4u	671	34	aldehyde	aldehyde	NN
cord-300872-blycbi4u	671	35	(	(	-LRB-
cord-300872-blycbi4u	671	36	isatin	isatin	NNP
cord-300872-blycbi4u	671	37	)	)	-RRB-
cord-300872-blycbi4u	671	38	105	105	CD
cord-300872-blycbi4u	671	39	[	[	-LRB-
cord-300872-blycbi4u	671	40	67	67	CD
cord-300872-blycbi4u	671	41	]	]	-RRB-
cord-300872-blycbi4u	671	42	,	,	,
cord-300872-blycbi4u	671	43	as	as	IN
cord-300872-blycbi4u	671	44	shown	show	VBN
cord-300872-blycbi4u	671	45	in	in	IN
cord-300872-blycbi4u	671	46	Scheme	Scheme	NNP
cord-300872-blycbi4u	671	47	25	25	CD
cord-300872-blycbi4u	671	48	.	.	.
cord-300872-blycbi4u	672	1	This	this	DT
cord-300872-blycbi4u	672	2	reaction	reaction	NN
cord-300872-blycbi4u	672	3	was	be	VBD
cord-300872-blycbi4u	672	4	conducted	conduct	VBN
cord-300872-blycbi4u	672	5	under	under	IN
cord-300872-blycbi4u	672	6	mild	mild	JJ
cord-300872-blycbi4u	672	7	experimental	experimental	JJ
cord-300872-blycbi4u	672	8	conditions	condition	NNS
cord-300872-blycbi4u	672	9	and	and	CC
cord-300872-blycbi4u	672	10	without	without	IN
cord-300872-blycbi4u	672	11	a	a	DT
cord-300872-blycbi4u	672	12	catalyst	catalyst	NN
cord-300872-blycbi4u	672	13	.	.	.
cord-300872-blycbi4u	673	1	nitriles	nitrile	NNS
cord-300872-blycbi4u	673	2	or	or	CC
cord-300872-blycbi4u	673	3	acetonitrile	acetonitrile	NN
cord-300872-blycbi4u	673	4	in	in	IN
cord-300872-blycbi4u	673	5	aqueous	aqueous	JJ
cord-300872-blycbi4u	673	6	potassium	potassium	NN
cord-300872-blycbi4u	673	7	hydroxide	hydroxide	NN
cord-300872-blycbi4u	673	8	solution	solution	NN
cord-300872-blycbi4u	673	9	yielded	yield	VBD
cord-300872-blycbi4u	673	10	1,2,4-triazole	1,2,4-triazole	CD
cord-300872-blycbi4u	673	11	-	-	HYPH
cord-300872-blycbi4u	673	12	based	base	VBN
cord-300872-blycbi4u	673	13	quinolone	quinolone	NNP
cord-300872-blycbi4u	673	14	(	(	-LRB-
cord-300872-blycbi4u	673	15	103	103	CD
cord-300872-blycbi4u	674	1	On	on	IN
cord-300872-blycbi4u	674	2	the	the	DT
cord-300872-blycbi4u	674	3	other	other	JJ
cord-300872-blycbi4u	674	4	hand	hand	NN
cord-300872-blycbi4u	674	5	,	,	,
cord-300872-blycbi4u	674	6	Kong	Kong	NNP
cord-300872-blycbi4u	674	7	et	et	NNP
cord-300872-blycbi4u	674	8	al	al	NNP
cord-300872-blycbi4u	674	9	.	.	.
cord-300872-blycbi4u	675	1	(	(	-LRB-
cord-300872-blycbi4u	675	2	2017	2017	CD
cord-300872-blycbi4u	675	3	)	)	-RRB-
cord-300872-blycbi4u	675	4	prepared	prepared	JJ
cord-300872-blycbi4u	675	5	novel	novel	JJ
cord-300872-blycbi4u	675	6	barbituroquinoline	barbituroquinoline	NN
cord-300872-blycbi4u	675	7	derivatives	derivative	NNS
cord-300872-blycbi4u	675	8	106	106	CD
cord-300872-blycbi4u	675	9	and	and	CC
cord-300872-blycbi4u	675	10	107	107	CD
cord-300872-blycbi4u	675	11	in	in	IN
cord-300872-blycbi4u	675	12	a	a	DT
cord-300872-blycbi4u	675	13	one	one	CD
cord-300872-blycbi4u	675	14	-	-	HYPH
cord-300872-blycbi4u	675	15	pot	pot	NN
cord-300872-blycbi4u	675	16	procedure	procedure	NN
cord-300872-blycbi4u	675	17	by	by	IN
cord-300872-blycbi4u	675	18	combining	combine	VBG
cord-300872-blycbi4u	675	19	three	three	CD
cord-300872-blycbi4u	675	20	components	component	NNS
cord-300872-blycbi4u	675	21	in	in	IN
cord-300872-blycbi4u	675	22	water	water	NN
cord-300872-blycbi4u	675	23	,	,	,
cord-300872-blycbi4u	675	24	namely	namely	RB
cord-300872-blycbi4u	675	25	1	1	CD
cord-300872-blycbi4u	675	26	,	,	,
cord-300872-blycbi4u	675	27	2-thiobarbituric	2-thiobarbituric	CD
cord-300872-blycbi4u	675	28	acid	acid	NN
cord-300872-blycbi4u	675	29	(	(	-LRB-
cord-300872-blycbi4u	675	30	104	104	CD
cord-300872-blycbi4u	675	31	)	)	-RRB-
cord-300872-blycbi4u	675	32	,	,	,
cord-300872-blycbi4u	675	33	and	and	CC
cord-300872-blycbi4u	675	34	aldehyde	aldehyde	NN
cord-300872-blycbi4u	675	35	(	(	-LRB-
cord-300872-blycbi4u	675	36	isatin	isatin	NNP
cord-300872-blycbi4u	675	37	)	)	-RRB-
cord-300872-blycbi4u	675	38	105	105	CD
cord-300872-blycbi4u	675	39	[	[	-LRB-
cord-300872-blycbi4u	675	40	67	67	CD
cord-300872-blycbi4u	675	41	]	]	-RRB-
cord-300872-blycbi4u	675	42	,	,	,
cord-300872-blycbi4u	675	43	as	as	IN
cord-300872-blycbi4u	675	44	shown	show	VBN
cord-300872-blycbi4u	675	45	in	in	IN
cord-300872-blycbi4u	675	46	Scheme	Scheme	NNP
cord-300872-blycbi4u	675	47	25	25	CD
cord-300872-blycbi4u	675	48	.	.	.
cord-300872-blycbi4u	676	1	This	this	DT
cord-300872-blycbi4u	676	2	reaction	reaction	NN
cord-300872-blycbi4u	676	3	was	be	VBD
cord-300872-blycbi4u	676	4	conducted	conduct	VBN
cord-300872-blycbi4u	676	5	under	under	IN
cord-300872-blycbi4u	676	6	mild	mild	JJ
cord-300872-blycbi4u	676	7	experimental	experimental	JJ
cord-300872-blycbi4u	676	8	conditions	condition	NNS
cord-300872-blycbi4u	676	9	and	and	CC
cord-300872-blycbi4u	676	10	without	without	IN
cord-300872-blycbi4u	676	11	a	a	DT
cord-300872-blycbi4u	676	12	catalyst	catalyst	NN
cord-300872-blycbi4u	676	13	.	.	.
cord-300872-blycbi4u	676	14	 	 	_SP
cord-300872-blycbi4u	677	1	The	the	DT
cord-300872-blycbi4u	677	2	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	677	3	moiety	moiety	NN
cord-300872-blycbi4u	677	4	can	can	MD
cord-300872-blycbi4u	677	5	act	act	VB
cord-300872-blycbi4u	677	6	as	as	IN
cord-300872-blycbi4u	677	7	a	a	DT
cord-300872-blycbi4u	677	8	building	building	NN
cord-300872-blycbi4u	677	9	block	block	NN
cord-300872-blycbi4u	677	10	for	for	IN
cord-300872-blycbi4u	677	11	various	various	JJ
cord-300872-blycbi4u	677	12	pharmacologically	pharmacologically	RB
cord-300872-blycbi4u	677	13	active	active	JJ
cord-300872-blycbi4u	677	14	scaffolds	scaffold	NNS
cord-300872-blycbi4u	677	15	.	.	.
cord-300872-blycbi4u	678	1	In	in	IN
cord-300872-blycbi4u	678	2	the	the	DT
cord-300872-blycbi4u	678	3	present	present	JJ
cord-300872-blycbi4u	678	4	work	work	NN
cord-300872-blycbi4u	678	5	,	,	,
cord-300872-blycbi4u	678	6	we	-PRON-	PRP
cord-300872-blycbi4u	678	7	have	have	VBP
cord-300872-blycbi4u	678	8	reviewed	review	VBN
cord-300872-blycbi4u	678	9	the	the	DT
cord-300872-blycbi4u	678	10	recent	recent	JJ
cord-300872-blycbi4u	678	11	literature	literature	NN
cord-300872-blycbi4u	678	12	pertaining	pertain	VBG
cord-300872-blycbi4u	678	13	to	to	IN
cord-300872-blycbi4u	678	14	the	the	DT
cord-300872-blycbi4u	678	15	synthesis	synthesis	NN
cord-300872-blycbi4u	678	16	and	and	CC
cord-300872-blycbi4u	678	17	bioactivity	bioactivity	NN
cord-300872-blycbi4u	678	18	of	of	IN
cord-300872-blycbi4u	678	19	numerous	numerous	JJ
cord-300872-blycbi4u	678	20	8-HQ	8-hq	CD
cord-300872-blycbi4u	678	21	derivatives	derivative	NNS
cord-300872-blycbi4u	678	22	as	as	IN
cord-300872-blycbi4u	678	23	anticancer	anticancer	JJ
cord-300872-blycbi4u	678	24	,	,	,
cord-300872-blycbi4u	678	25	antiviral	antiviral	JJ
cord-300872-blycbi4u	678	26	,	,	,
cord-300872-blycbi4u	678	27	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	678	28	,	,	,
cord-300872-blycbi4u	678	29	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	678	30	,	,	,
cord-300872-blycbi4u	678	31	antifungal	antifungal	JJ
cord-300872-blycbi4u	678	32	,	,	,
cord-300872-blycbi4u	678	33	and	and	CC
cord-300872-blycbi4u	678	34	anticancer	anticancer	JJ
cord-300872-blycbi4u	678	35	agents	agent	NNS
cord-300872-blycbi4u	678	36	.	.	.
cord-300872-blycbi4u	679	1	The	the	DT
cord-300872-blycbi4u	679	2	results	result	NNS
cord-300872-blycbi4u	679	3	obtained	obtain	VBN
cord-300872-blycbi4u	679	4	from	from	IN
cord-300872-blycbi4u	679	5	this	this	DT
cord-300872-blycbi4u	679	6	review	review	NN
cord-300872-blycbi4u	679	7	highlight	highlight	VB
cord-300872-blycbi4u	679	8	the	the	DT
cord-300872-blycbi4u	679	9	importance	importance	NN
cord-300872-blycbi4u	679	10	of	of	IN
cord-300872-blycbi4u	679	11	numerous	numerous	JJ
cord-300872-blycbi4u	679	12	derivatives	derivative	NNS
cord-300872-blycbi4u	679	13	of	of	IN
cord-300872-blycbi4u	679	14	8-HQ	8-hq	CD
cord-300872-blycbi4u	679	15	as	as	IN
cord-300872-blycbi4u	679	16	possible	possible	JJ
cord-300872-blycbi4u	679	17	chemotherapeutic	chemotherapeutic	JJ
cord-300872-blycbi4u	679	18	agents	agent	NNS
cord-300872-blycbi4u	679	19	and	and	CC
cord-300872-blycbi4u	679	20	as	as	IN
cord-300872-blycbi4u	679	21	possible	possible	JJ
cord-300872-blycbi4u	679	22	leads	lead	VBZ
cord-300872-blycbi4u	679	23	towards	towards	IN
cord-300872-blycbi4u	679	24	the	the	DT
cord-300872-blycbi4u	679	25	development	development	NN
cord-300872-blycbi4u	679	26	of	of	IN
cord-300872-blycbi4u	679	27	new	new	JJ
cord-300872-blycbi4u	679	28	drugs	drug	NNS
cord-300872-blycbi4u	679	29	to	to	TO
cord-300872-blycbi4u	679	30	treat	treat	VB
cord-300872-blycbi4u	679	31	various	various	JJ
cord-300872-blycbi4u	679	32	diseases	disease	NNS
cord-300872-blycbi4u	679	33	,	,	,
cord-300872-blycbi4u	679	34	including	include	VBG
cord-300872-blycbi4u	679	35	cancer	cancer	NN
cord-300872-blycbi4u	679	36	.	.	.
cord-300872-blycbi4u	680	1	We	-PRON-	PRP
cord-300872-blycbi4u	680	2	hope	hope	VBP
cord-300872-blycbi4u	680	3	that	that	IN
cord-300872-blycbi4u	680	4	data	datum	NNS
cord-300872-blycbi4u	680	5	presented	present	VBN
cord-300872-blycbi4u	680	6	in	in	IN
cord-300872-blycbi4u	680	7	this	this	DT
cord-300872-blycbi4u	680	8	review	review	NN
cord-300872-blycbi4u	680	9	could	could	MD
cord-300872-blycbi4u	680	10	help	help	VB
cord-300872-blycbi4u	680	11	researchers	researcher	NNS
cord-300872-blycbi4u	680	12	in	in	IN
cord-300872-blycbi4u	680	13	the	the	DT
cord-300872-blycbi4u	680	14	fields	field	NNS
cord-300872-blycbi4u	680	15	of	of	IN
cord-300872-blycbi4u	680	16	medicinal	medicinal	JJ
cord-300872-blycbi4u	680	17	chemistry	chemistry	NN
cord-300872-blycbi4u	680	18	and	and	CC
cord-300872-blycbi4u	680	19	pharmacology	pharmacology	NN
cord-300872-blycbi4u	680	20	in	in	IN
cord-300872-blycbi4u	680	21	designing	design	VBG
cord-300872-blycbi4u	680	22	new	new	JJ
cord-300872-blycbi4u	680	23	active	active	JJ
cord-300872-blycbi4u	680	24	compounds	compound	NNS
cord-300872-blycbi4u	680	25	and	and	CC
cord-300872-blycbi4u	680	26	in	in	IN
cord-300872-blycbi4u	680	27	the	the	DT
cord-300872-blycbi4u	680	28	modification	modification	NN
cord-300872-blycbi4u	680	29	of	of	IN
cord-300872-blycbi4u	680	30	existing	exist	VBG
cord-300872-blycbi4u	680	31	compounds	compound	NNS
cord-300872-blycbi4u	680	32	in	in	IN
cord-300872-blycbi4u	680	33	the	the	DT
cord-300872-blycbi4u	680	34	search	search	NN
cord-300872-blycbi4u	680	35	for	for	IN
cord-300872-blycbi4u	680	36	new	new	JJ
cord-300872-blycbi4u	680	37	drug	drug	NN
cord-300872-blycbi4u	680	38	leads	lead	NNS
cord-300872-blycbi4u	680	39	.	.	.
cord-300872-blycbi4u	681	1	The	the	DT
cord-300872-blycbi4u	681	2	development	development	NN
cord-300872-blycbi4u	681	3	of	of	IN
cord-300872-blycbi4u	681	4	drugs	drug	NNS
cord-300872-blycbi4u	681	5	,	,	,
cord-300872-blycbi4u	681	6	either	either	CC
cord-300872-blycbi4u	681	7	natural	natural	JJ
cord-300872-blycbi4u	681	8	or	or	CC
cord-300872-blycbi4u	681	9	synthetic	synthetic	JJ
cord-300872-blycbi4u	681	10	,	,	,
cord-300872-blycbi4u	681	11	is	be	VBZ
cord-300872-blycbi4u	681	12	gaining	gain	VBG
cord-300872-blycbi4u	681	13	popularity	popularity	NN
cord-300872-blycbi4u	681	14	in	in	IN
cord-300872-blycbi4u	681	15	the	the	DT
cord-300872-blycbi4u	681	16	fight	fight	NN
cord-300872-blycbi4u	681	17	against	against	IN
cord-300872-blycbi4u	681	18	diseases	disease	NNS
cord-300872-blycbi4u	681	19	,	,	,
cord-300872-blycbi4u	681	20	such	such	JJ
cord-300872-blycbi4u	681	21	as	as	IN
cord-300872-blycbi4u	681	22	cardiovascular	cardiovascular	JJ
cord-300872-blycbi4u	681	23	disorders	disorder	NNS
cord-300872-blycbi4u	681	24	,	,	,
cord-300872-blycbi4u	681	25	cancer	cancer	NN
cord-300872-blycbi4u	681	26	insurgence	insurgence	NN
cord-300872-blycbi4u	681	27	,	,	,
cord-300872-blycbi4u	681	28	and	and	CC
cord-300872-blycbi4u	681	29	immune	immune	JJ
cord-300872-blycbi4u	681	30	dysfunction	dysfunction	NN
cord-300872-blycbi4u	681	31	.	.	.
cord-300872-blycbi4u	682	1	There	there	EX
cord-300872-blycbi4u	682	2	are	be	VBP
cord-300872-blycbi4u	682	3	certain	certain	JJ
cord-300872-blycbi4u	682	4	nuclei	nucleus	NNS
cord-300872-blycbi4u	682	5	such	such	JJ
cord-300872-blycbi4u	682	6	as	as	IN
cord-300872-blycbi4u	682	7	8-HQ	8-hq	CD
cord-300872-blycbi4u	682	8	that	that	WDT
cord-300872-blycbi4u	682	9	are	be	VBP
cord-300872-blycbi4u	682	10	important	important	JJ
cord-300872-blycbi4u	682	11	building	building	NN
cord-300872-blycbi4u	682	12	blocks	block	NNS
cord-300872-blycbi4u	682	13	in	in	IN
cord-300872-blycbi4u	682	14	the	the	DT
cord-300872-blycbi4u	682	15	medicinal	medicinal	JJ
cord-300872-blycbi4u	682	16	arena	arena	NN
cord-300872-blycbi4u	682	17	.	.	.
cord-300872-blycbi4u	683	1	Therefore	therefore	RB
cord-300872-blycbi4u	683	2	,	,	,
cord-300872-blycbi4u	683	3	new	new	JJ
cord-300872-blycbi4u	683	4	synthetic	synthetic	JJ
cord-300872-blycbi4u	683	5	methods	method	NNS
cord-300872-blycbi4u	683	6	for	for	IN
cord-300872-blycbi4u	683	7	bioactive	bioactive	JJ
cord-300872-blycbi4u	683	8	8-HQ	8-hq	CD
cord-300872-blycbi4u	683	9	derivatives	derivative	NNS
cord-300872-blycbi4u	683	10	should	should	MD
cord-300872-blycbi4u	683	11	be	be	VB
cord-300872-blycbi4u	683	12	pursued	pursue	VBN
cord-300872-blycbi4u	683	13	.	.	.
cord-300872-blycbi4u	684	1	In	in	IN
cord-300872-blycbi4u	684	2	this	this	DT
cord-300872-blycbi4u	684	3	respect	respect	NN
cord-300872-blycbi4u	684	4	,	,	,
cord-300872-blycbi4u	684	5	more	more	RBR
cord-300872-blycbi4u	684	6	biological	biological	JJ
cord-300872-blycbi4u	684	7	testing	testing	NN
cord-300872-blycbi4u	684	8	,	,	,
cord-300872-blycbi4u	684	9	including	include	VBG
cord-300872-blycbi4u	684	10	in	in	IN
cord-300872-blycbi4u	684	11	vivo	vivo	NNP
cord-300872-blycbi4u	684	12	studies	study	NNS
cord-300872-blycbi4u	684	13	,	,	,
cord-300872-blycbi4u	684	14	should	should	MD
cord-300872-blycbi4u	684	15	accompany	accompany	VB
cord-300872-blycbi4u	684	16	these	these	DT
cord-300872-blycbi4u	684	17	syntheses	synthesis	NNS
cord-300872-blycbi4u	684	18	.	.	.
cord-300872-blycbi4u	685	1	Studies	study	NNS
cord-300872-blycbi4u	685	2	should	should	MD
cord-300872-blycbi4u	685	3	also	also	RB
cord-300872-blycbi4u	685	4	involve	involve	VB
cord-300872-blycbi4u	685	5	different	different	JJ
cord-300872-blycbi4u	685	6	pharmacokinetic	pharmacokinetic	JJ
cord-300872-blycbi4u	685	7	parameters	parameter	NNS
cord-300872-blycbi4u	685	8	related	relate	VBN
cord-300872-blycbi4u	685	9	to	to	IN
cord-300872-blycbi4u	685	10	the	the	DT
cord-300872-blycbi4u	685	11	safety	safety	NN
cord-300872-blycbi4u	685	12	profiles	profile	NNS
cord-300872-blycbi4u	685	13	of	of	IN
cord-300872-blycbi4u	685	14	potent	potent	JJ
cord-300872-blycbi4u	685	15	derivatives	derivative	NNS
cord-300872-blycbi4u	685	16	.	.	.
cord-300872-blycbi4u	686	1	In	in	IN
cord-300872-blycbi4u	686	2	this	this	DT
cord-300872-blycbi4u	686	3	review	review	NN
cord-300872-blycbi4u	686	4	,	,	,
cord-300872-blycbi4u	686	5	we	-PRON-	PRP
cord-300872-blycbi4u	686	6	have	have	VBP
cord-300872-blycbi4u	686	7	shown	show	VBN
cord-300872-blycbi4u	686	8	different	different	JJ
cord-300872-blycbi4u	686	9	synthetic	synthetic	JJ
cord-300872-blycbi4u	686	10	strategies	strategy	NNS
cord-300872-blycbi4u	686	11	for	for	IN
cord-300872-blycbi4u	686	12	pharmaceutically	pharmaceutically	RB
cord-300872-blycbi4u	686	13	important	important	JJ
cord-300872-blycbi4u	686	14	chemicals	chemical	NNS
cord-300872-blycbi4u	686	15	that	that	WDT
cord-300872-blycbi4u	686	16	incorporate	incorporate	VBP
cord-300872-blycbi4u	686	17	the	the	DT
cord-300872-blycbi4u	686	18	8-HQ	8-hq	CD
cord-300872-blycbi4u	686	19	moiety	moiety	NN
cord-300872-blycbi4u	686	20	.	.	.
cord-300872-blycbi4u	687	1	These	these	DT
cord-300872-blycbi4u	687	2	compounds	compound	NNS
cord-300872-blycbi4u	687	3	exhibited	exhibit	VBD
cord-300872-blycbi4u	687	4	a	a	DT
cord-300872-blycbi4u	687	5	wide	wide	JJ
cord-300872-blycbi4u	687	6	range	range	NN
cord-300872-blycbi4u	687	7	of	of	IN
cord-300872-blycbi4u	687	8	biological	biological	JJ
cord-300872-blycbi4u	687	9	activities	activity	NNS
cord-300872-blycbi4u	687	10	and	and	CC
cord-300872-blycbi4u	687	11	could	could	MD
cord-300872-blycbi4u	687	12	be	be	VB
cord-300872-blycbi4u	687	13	used	use	VBN
cord-300872-blycbi4u	687	14	as	as	IN
cord-300872-blycbi4u	687	15	therapeutic	therapeutic	JJ
cord-300872-blycbi4u	687	16	agents	agent	NNS
cord-300872-blycbi4u	687	17	against	against	IN
cord-300872-blycbi4u	687	18	different	different	JJ
cord-300872-blycbi4u	687	19	diseases	disease	NNS
cord-300872-blycbi4u	687	20	,	,	,
cord-300872-blycbi4u	687	21	including	include	VBG
cord-300872-blycbi4u	687	22	cancer	cancer	NN
cord-300872-blycbi4u	687	23	.	.	.
cord-300872-blycbi4u	688	1	Some	some	DT
cord-300872-blycbi4u	688	2	of	of	IN
cord-300872-blycbi4u	688	3	these	these	DT
cord-300872-blycbi4u	688	4	compounds	compound	NNS
cord-300872-blycbi4u	688	5	could	could	MD
cord-300872-blycbi4u	688	6	be	be	VB
cord-300872-blycbi4u	688	7	envisioned	envision	VBN
cord-300872-blycbi4u	688	8	as	as	IN
cord-300872-blycbi4u	688	9	leads	lead	NNS
cord-300872-blycbi4u	688	10	in	in	IN
cord-300872-blycbi4u	688	11	the	the	DT
cord-300872-blycbi4u	688	12	development	development	NN
cord-300872-blycbi4u	688	13	of	of	IN
cord-300872-blycbi4u	688	14	drugs	drug	NNS
cord-300872-blycbi4u	688	15	.	.	.
cord-300872-blycbi4u	689	1	Compound	compound	NN
cord-300872-blycbi4u	689	2	101	101	CD
cord-300872-blycbi4u	689	3	then	then	RB
cord-300872-blycbi4u	689	4	reacted	react	VBD
cord-300872-blycbi4u	689	5	with	with	IN
cord-300872-blycbi4u	689	6	alkenes	alkene	NNS
cord-300872-blycbi4u	689	7	or	or	CC
cord-300872-blycbi4u	689	8	alkynes	alkyne	NNS
cord-300872-blycbi4u	689	9	containing	contain	VBG
cord-300872-blycbi4u	689	10	electron	electron	NN
cord-300872-blycbi4u	689	11	-	-	HYPH
cord-300872-blycbi4u	689	12	withdrawing	withdraw	VBG
cord-300872-blycbi4u	689	13	substituents	substituent	NNS
cord-300872-blycbi4u	689	14	under	under	IN
cord-300872-blycbi4u	689	15	the	the	DT
cord-300872-blycbi4u	689	16	mechanism	mechanism	NN
cord-300872-blycbi4u	689	17	of	of	IN
cord-300872-blycbi4u	689	18	1,3-dipolarcycloaddition	1,3-dipolarcycloaddition	CD
cord-300872-blycbi4u	689	19	and	and	CC
cord-300872-blycbi4u	689	20	in	in	IN
cord-300872-blycbi4u	689	21	the	the	DT
cord-300872-blycbi4u	689	22	presence	presence	NN
cord-300872-blycbi4u	689	23	of	of	IN
cord-300872-blycbi4u	689	24	a	a	DT
cord-300872-blycbi4u	689	25	base	base	NN
cord-300872-blycbi4u	689	26	(	(	-LRB-
cord-300872-blycbi4u	689	27	K	K	NNP
cord-300872-blycbi4u	689	28	2	2	CD
cord-300872-blycbi4u	689	29	CO	CO	NNP
cord-300872-blycbi4u	689	30	3	3	CD
cord-300872-blycbi4u	689	31	)	)	-RRB-
cord-300872-blycbi4u	689	32	to	to	TO
cord-300872-blycbi4u	689	33	afford	afford	VB
cord-300872-blycbi4u	689	34	102	102	CD
cord-300872-blycbi4u	689	35	.	.	.
cord-300872-blycbi4u	690	1	On	on	IN
cord-300872-blycbi4u	690	2	the	the	DT
cord-300872-blycbi4u	690	3	other	other	JJ
cord-300872-blycbi4u	690	4	hand	hand	NN
cord-300872-blycbi4u	690	5	,	,	,
cord-300872-blycbi4u	690	6	the	the	DT
cord-300872-blycbi4u	690	7	reaction	reaction	NN
cord-300872-blycbi4u	690	8	of	of	IN
cord-300872-blycbi4u	690	9	101	101	CD
cord-300872-blycbi4u	690	10	with	with	IN
cord-300872-blycbi4u	690	11	aromatic	aromatic	JJ
cord-300872-blycbi4u	690	12	nitriles	nitrile	NNS
cord-300872-blycbi4u	690	13	or	or	CC
cord-300872-blycbi4u	690	14	acetonitrile	acetonitrile	NN
cord-300872-blycbi4u	690	15	in	in	IN
cord-300872-blycbi4u	690	16	aqueous	aqueous	JJ
cord-300872-blycbi4u	690	17	potassium	potassium	NN
cord-300872-blycbi4u	690	18	hydroxide	hydroxide	NN
cord-300872-blycbi4u	690	19	solution	solution	NN
cord-300872-blycbi4u	690	20	yielded	yield	VBD
cord-300872-blycbi4u	690	21	1,2,4-triazole	1,2,4-triazole	CD
cord-300872-blycbi4u	690	22	-	-	HYPH
cord-300872-blycbi4u	690	23	based	base	VBN
cord-300872-blycbi4u	690	24	quinolone	quinolone	NNP
cord-300872-blycbi4u	690	25	(	(	-LRB-
cord-300872-blycbi4u	690	26	103	103	CD
cord-300872-blycbi4u	690	27	)	)	-RRB-
cord-300872-blycbi4u	690	28	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	690	29	and	and	CC
cord-300872-blycbi4u	690	30	its	-PRON-	PRP$
cord-300872-blycbi4u	690	31	derivatives	derivative	NNS
cord-300872-blycbi4u	690	32	:	:	:
cord-300872-blycbi4u	690	33	Synthesis	synthesis	NN
cord-300872-blycbi4u	690	34	and	and	CC
cord-300872-blycbi4u	690	35	applications	application	NNS
cord-300872-blycbi4u	690	36	Immiscible	Immiscible	NNP
cord-300872-blycbi4u	690	37	polymers	polymer	NNS
cord-300872-blycbi4u	690	38	in	in	IN
cord-300872-blycbi4u	690	39	double	double	JJ
cord-300872-blycbi4u	690	40	spin	spin	NN
cord-300872-blycbi4u	690	41	-	-	HYPH
cord-300872-blycbi4u	690	42	coated	coat	VBN
cord-300872-blycbi4u	690	43	electroluminescent	electroluminescent	NN
cord-300872-blycbi4u	690	44	devices	device	NNS
cord-300872-blycbi4u	690	45	containing	contain	VBG
cord-300872-blycbi4u	690	46	phenyl	phenyl	NN
cord-300872-blycbi4u	690	47	-	-	HYPH
cord-300872-blycbi4u	690	48	substituted	substitute	VBN
cord-300872-blycbi4u	690	49	Tris	Tris	NNP
cord-300872-blycbi4u	690	50	(	(	-LRB-
cord-300872-blycbi4u	690	51	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	690	52	)	)	-RRB-
cord-300872-blycbi4u	690	53	aluminum	aluminum	NN
cord-300872-blycbi4u	690	54	derivatives	derivative	NNS
cord-300872-blycbi4u	690	55	soluble	soluble	JJ
cord-300872-blycbi4u	690	56	in	in	IN
cord-300872-blycbi4u	690	57	a	a	DT
cord-300872-blycbi4u	690	58	host	host	NN
cord-300872-blycbi4u	690	59	polymer	polymer	NN
cord-300872-blycbi4u	690	60	8-Hydroxyquinolines	8-hydroxyquinolines	CD
cord-300872-blycbi4u	690	61	in	in	IN
cord-300872-blycbi4u	690	62	medicinal	medicinal	JJ
cord-300872-blycbi4u	690	63	chemistry	chemistry	NN
cord-300872-blycbi4u	690	64	:	:	:
cord-300872-blycbi4u	690	65	A	a	DT
cord-300872-blycbi4u	690	66	structural	structural	JJ
cord-300872-blycbi4u	690	67	perspective	perspective	NN
cord-300872-blycbi4u	690	68	8-Hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	690	69	:	:	:
cord-300872-blycbi4u	691	1	A	a	DT
cord-300872-blycbi4u	691	2	privileged	privileged	JJ
cord-300872-blycbi4u	691	3	structure	structure	NN
cord-300872-blycbi4u	691	4	with	with	IN
cord-300872-blycbi4u	691	5	a	a	DT
cord-300872-blycbi4u	691	6	broad	broad	RB
cord-300872-blycbi4u	691	7	-	-	HYPH
cord-300872-blycbi4u	691	8	ranging	range	VBG
cord-300872-blycbi4u	691	9	pharmacological	pharmacological	JJ
cord-300872-blycbi4u	691	10	potential	potential	JJ
cord-300872-blycbi4u	691	11	Synthesis	synthesis	NN
cord-300872-blycbi4u	691	12	,	,	,
cord-300872-blycbi4u	691	13	characterization	characterization	NN
cord-300872-blycbi4u	691	14	,	,	,
cord-300872-blycbi4u	691	15	and	and	CC
cord-300872-blycbi4u	691	16	anti	anti	JJ
cord-300872-blycbi4u	691	17	-	-	JJ
cord-300872-blycbi4u	691	18	corrosion	corrosion	JJ
cord-300872-blycbi4u	691	19	properties	property	NNS
cord-300872-blycbi4u	691	20	of	of	IN
cord-300872-blycbi4u	691	21	an	an	DT
cord-300872-blycbi4u	691	22	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	691	23	derivative	derivative	JJ
cord-300872-blycbi4u	691	24	Synthesis	synthesis	NN
cord-300872-blycbi4u	691	25	and	and	CC
cord-300872-blycbi4u	691	26	characterization	characterization	NN
cord-300872-blycbi4u	691	27	of	of	IN
cord-300872-blycbi4u	691	28	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	691	29	complexes	complex	NNS
cord-300872-blycbi4u	691	30	of	of	IN
cord-300872-blycbi4u	691	31	Tin	Tin	NNP
cord-300872-blycbi4u	691	32	(	(	-LRB-
cord-300872-blycbi4u	691	33	Iv	Iv	NNP
cord-300872-blycbi4u	691	34	)	)	-RRB-
cord-300872-blycbi4u	691	35	and	and	CC
cord-300872-blycbi4u	691	36	their	-PRON-	PRP$
cord-300872-blycbi4u	691	37	application	application	NN
cord-300872-blycbi4u	691	38	in	in	IN
cord-300872-blycbi4u	691	39	organic	organic	JJ
cord-300872-blycbi4u	691	40	light	light	NN
cord-300872-blycbi4u	691	41	emitting	emit	VBG
cord-300872-blycbi4u	691	42	diode	diode	NN
cord-300872-blycbi4u	691	43	Antiviral	antiviral	JJ
cord-300872-blycbi4u	691	44	activity	activity	NN
cord-300872-blycbi4u	691	45	of	of	IN
cord-300872-blycbi4u	691	46	novel	novel	JJ
cord-300872-blycbi4u	691	47	quinoline	quinoline	NN
cord-300872-blycbi4u	691	48	derivatives	derivative	NNS
cord-300872-blycbi4u	691	49	against	against	IN
cord-300872-blycbi4u	691	50	dengue	dengue	NN
cord-300872-blycbi4u	691	51	virus	virus	NN
cord-300872-blycbi4u	691	52	serotype	serotype	NN
cord-300872-blycbi4u	691	53	2	2	CD
cord-300872-blycbi4u	691	54	8-Hydroxyquinoline-2-carboxanilides	8-hydroxyquinoline-2-carboxanilides	CD
cord-300872-blycbi4u	691	55	as	as	IN
cord-300872-blycbi4u	691	56	antiviral	antiviral	JJ
cord-300872-blycbi4u	691	57	agents	agent	NNS
cord-300872-blycbi4u	691	58	against	against	IN
cord-300872-blycbi4u	691	59	Avian	avian	JJ
cord-300872-blycbi4u	691	60	influenza	influenza	NN
cord-300872-blycbi4u	691	61	virus	virus	NN
cord-300872-blycbi4u	691	62	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	691	63	and	and	CC
cord-300872-blycbi4u	691	64	Antibacterial	antibacterial	JJ
cord-300872-blycbi4u	691	65	activity	activity	NN
cord-300872-blycbi4u	691	66	of	of	IN
cord-300872-blycbi4u	691	67	3-benzylamide	3-benzylamide	CD
cord-300872-blycbi4u	691	68	derivatives	derivative	NNS
cord-300872-blycbi4u	691	69	as	as	IN
cord-300872-blycbi4u	691	70	Ftsz	Ftsz	NNP
cord-300872-blycbi4u	691	71	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	692	1	Chemoselective	chemoselective	JJ
cord-300872-blycbi4u	692	2	synthesis	synthesis	NN
cord-300872-blycbi4u	692	3	of	of	IN
cord-300872-blycbi4u	692	4	5-Amino-7-Bromoquinolin-8-Yl	5-amino-7-bromoquinolin-8-yl	CD
cord-300872-blycbi4u	692	5	Sulfonate	Sulfonate	NNP
cord-300872-blycbi4u	692	6	derivatives	derivative	NNS
cord-300872-blycbi4u	692	7	and	and	CC
cord-300872-blycbi4u	692	8	their	-PRON-	PRP$
cord-300872-blycbi4u	692	9	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	692	10	evaluation	evaluation	NN
cord-300872-blycbi4u	692	11	Synthesis	synthesis	NN
cord-300872-blycbi4u	692	12	,	,	,
cord-300872-blycbi4u	692	13	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	692	14	properties	property	NNS
cord-300872-blycbi4u	692	15	and	and	CC
cord-300872-blycbi4u	692	16	bioinformatics	bioinformatics	NN
cord-300872-blycbi4u	692	17	computational	computational	JJ
cord-300872-blycbi4u	692	18	analyses	analysis	NNS
cord-300872-blycbi4u	692	19	of	of	IN
cord-300872-blycbi4u	692	20	novel	novel	JJ
cord-300872-blycbi4u	692	21	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	692	22	derivatives	derivative	NNS
cord-300872-blycbi4u	692	23	Synthesis	synthesis	NN
cord-300872-blycbi4u	692	24	and	and	CC
cord-300872-blycbi4u	692	25	biological	biological	JJ
cord-300872-blycbi4u	692	26	evaluation	evaluation	NN
cord-300872-blycbi4u	692	27	of	of	IN
cord-300872-blycbi4u	692	28	quinoline	quinoline	JJ
cord-300872-blycbi4u	692	29	derivatives	derivative	NNS
cord-300872-blycbi4u	692	30	as	as	IN
cord-300872-blycbi4u	692	31	a	a	DT
cord-300872-blycbi4u	692	32	novel	novel	JJ
cord-300872-blycbi4u	692	33	class	class	NN
cord-300872-blycbi4u	692	34	of	of	IN
cord-300872-blycbi4u	692	35	broad	broad	JJ
cord-300872-blycbi4u	692	36	-	-	HYPH
cord-300872-blycbi4u	692	37	spectrum	spectrum	NN
cord-300872-blycbi4u	692	38	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	692	39	agents	agent	NNS
cord-300872-blycbi4u	692	40	In	in	IN
cord-300872-blycbi4u	692	41	Vitro	Vitro	NNP
cord-300872-blycbi4u	692	42	activities	activity	NNS
cord-300872-blycbi4u	692	43	of	of	IN
cord-300872-blycbi4u	692	44	a	a	DT
cord-300872-blycbi4u	692	45	new	new	JJ
cord-300872-blycbi4u	692	46	fluoroquinolone	fluoroquinolone	NN
cord-300872-blycbi4u	692	47	derivative	derivative	NN
cord-300872-blycbi4u	692	48	highly	highly	RB
cord-300872-blycbi4u	692	49	active	active	JJ
cord-300872-blycbi4u	692	50	against	against	IN
cord-300872-blycbi4u	692	51	Chlamydia	Chlamydia	NNP
cord-300872-blycbi4u	692	52	trachomatis	trachomatis	NN
cord-300872-blycbi4u	692	53	Antifungal	antifungal	JJ
cord-300872-blycbi4u	692	54	activity	activity	NN
cord-300872-blycbi4u	692	55	of	of	IN
cord-300872-blycbi4u	692	56	Umbelliferone	Umbelliferone	NNP
cord-300872-blycbi4u	692	57	derivatives	derivative	NNS
cord-300872-blycbi4u	692	58	:	:	:
cord-300872-blycbi4u	693	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	693	2	and	and	CC
cord-300872-blycbi4u	693	3	structure	structure	NN
cord-300872-blycbi4u	693	4	-	-	HYPH
cord-300872-blycbi4u	693	5	activity	activity	NN
cord-300872-blycbi4u	693	6	relationships	relationship	NNS
cord-300872-blycbi4u	693	7	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	693	8	of	of	IN
cord-300872-blycbi4u	693	9	some	some	DT
cord-300872-blycbi4u	693	10	novel	novel	JJ
cord-300872-blycbi4u	693	11	3	3	CD
cord-300872-blycbi4u	693	12	,	,	,
cord-300872-blycbi4u	693	13	4	4	CD
cord-300872-blycbi4u	693	14	,	,	,
cord-300872-blycbi4u	693	15	5-trisubstituted	5-trisubstituted	CD
cord-300872-blycbi4u	693	16	Triazole	Triazole	NNP
cord-300872-blycbi4u	693	17	derivatives	derivative	NNS
cord-300872-blycbi4u	693	18	bearing	bear	VBG
cord-300872-blycbi4u	693	19	quinoline	quinoline	JJ
cord-300872-blycbi4u	693	20	ring	ring	NN
cord-300872-blycbi4u	693	21	and	and	CC
cord-300872-blycbi4u	693	22	evaluation	evaluation	NN
cord-300872-blycbi4u	693	23	of	of	IN
cord-300872-blycbi4u	693	24	their	-PRON-	PRP$
cord-300872-blycbi4u	693	25	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	693	26	activity	activity	NN
cord-300872-blycbi4u	694	1	A	a	DT
cord-300872-blycbi4u	694	2	comprehensive	comprehensive	JJ
cord-300872-blycbi4u	694	3	review	review	NN
cord-300872-blycbi4u	694	4	on	on	IN
cord-300872-blycbi4u	694	5	the	the	DT
cord-300872-blycbi4u	694	6	chemotherapeutic	chemotherapeutic	JJ
cord-300872-blycbi4u	694	7	potential	potential	NN
cord-300872-blycbi4u	694	8	of	of	IN
cord-300872-blycbi4u	694	9	Piceatannol	Piceatannol	NNP
cord-300872-blycbi4u	694	10	for	for	IN
cord-300872-blycbi4u	694	11	cancer	cancer	NN
cord-300872-blycbi4u	694	12	treatment	treatment	NN
cord-300872-blycbi4u	694	13	,	,	,
cord-300872-blycbi4u	694	14	with	with	IN
cord-300872-blycbi4u	694	15	mechanistic	mechanistic	JJ
cord-300872-blycbi4u	694	16	insights	insight	NNS
cord-300872-blycbi4u	694	17	A	a	DT
cord-300872-blycbi4u	694	18	novel	novel	JJ
cord-300872-blycbi4u	694	19	potent	potent	JJ
cord-300872-blycbi4u	694	20	Nicotinamide	Nicotinamide	NNP
cord-300872-blycbi4u	694	21	Phosphoribosyltransferase	Phosphoribosyltransferase	NNP
cord-300872-blycbi4u	694	22	inhibitor	inhibitor	NN
cord-300872-blycbi4u	694	23	synthesized	synthesize	VBN
cord-300872-blycbi4u	694	24	via	via	IN
cord-300872-blycbi4u	694	25	click	click	NN
cord-300872-blycbi4u	694	26	chemistry	chemistry	NN
cord-300872-blycbi4u	694	27	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	694	28	and	and	CC
cord-300872-blycbi4u	694	29	structure	structure	NN
cord-300872-blycbi4u	694	30	-	-	HYPH
cord-300872-blycbi4u	694	31	activity	activity	NN
cord-300872-blycbi4u	694	32	relationships	relationship	NNS
cord-300872-blycbi4u	694	33	study	study	NN
cord-300872-blycbi4u	694	34	of	of	IN
cord-300872-blycbi4u	694	35	A	a	DT
cord-300872-blycbi4u	694	36	-	-	HYPH
cord-300872-blycbi4u	694	37	Aminophosphonate	Aminophosphonate	NNP
cord-300872-blycbi4u	694	38	derivatives	derivative	NNS
cord-300872-blycbi4u	694	39	containing	contain	VBG
cord-300872-blycbi4u	694	40	a	a	DT
cord-300872-blycbi4u	694	41	Quinoline	Quinoline	NNP
cord-300872-blycbi4u	694	42	moiety	moiety	VBZ
cord-300872-blycbi4u	694	43	An	an	DT
cord-300872-blycbi4u	694	44	extremely	extremely	RB
cord-300872-blycbi4u	694	45	stable	stable	JJ
cord-300872-blycbi4u	694	46	and	and	CC
cord-300872-blycbi4u	694	47	orthogonal	orthogonal	JJ
cord-300872-blycbi4u	694	48	DNA	dna	NN
cord-300872-blycbi4u	694	49	base	base	NN
cord-300872-blycbi4u	694	50	pair	pair	NN
cord-300872-blycbi4u	694	51	with	with	IN
cord-300872-blycbi4u	694	52	a	a	DT
cord-300872-blycbi4u	694	53	simplified	simplified	JJ
cord-300872-blycbi4u	694	54	three	three	CD
cord-300872-blycbi4u	694	55	-	-	HYPH
cord-300872-blycbi4u	694	56	carbon	carbon	NN
cord-300872-blycbi4u	694	57	backbone	backbone	NN
cord-300872-blycbi4u	694	58	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	694	59	and	and	CC
cord-300872-blycbi4u	694	60	investigation	investigation	NN
cord-300872-blycbi4u	694	61	of	of	IN
cord-300872-blycbi4u	694	62	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	694	63	and	and	CC
cord-300872-blycbi4u	694	64	antioxidants	antioxidant	NNS
cord-300872-blycbi4u	694	65	properties	property	NNS
cord-300872-blycbi4u	694	66	of	of	IN
cord-300872-blycbi4u	694	67	some	some	DT
cord-300872-blycbi4u	694	68	new	new	JJ
cord-300872-blycbi4u	694	69	5-subsituted-8-Hydroxyquinoline	5-subsituted-8-hydroxyquinoline	CD
cord-300872-blycbi4u	694	70	derivatives	derivative	NNS
cord-300872-blycbi4u	694	71	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	694	72	,	,	,
cord-300872-blycbi4u	694	73	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	694	74	characterization	characterization	NN
cord-300872-blycbi4u	694	75	,	,	,
cord-300872-blycbi4u	694	76	X	x	NN
cord-300872-blycbi4u	694	77	-	-	NN
cord-300872-blycbi4u	694	78	ray	ray	JJ
cord-300872-blycbi4u	694	79	analysis	analysis	NN
cord-300872-blycbi4u	694	80	,	,	,
cord-300872-blycbi4u	694	81	and	and	CC
cord-300872-blycbi4u	694	82	Dft	Dft	NNP
cord-300872-blycbi4u	694	83	-	-	HYPH
cord-300872-blycbi4u	694	84	Hf	Hf	NNP
cord-300872-blycbi4u	694	85	calculations	calculation	NNS
cord-300872-blycbi4u	694	86	of	of	IN
cord-300872-blycbi4u	694	87	5-Ethoxymethyl-8-Hydroxyquinoline	5-ethoxymethyl-8-hydroxyquinoline	CD
cord-300872-blycbi4u	694	88	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	694	89	and	and	CC
cord-300872-blycbi4u	694	90	antimicrobial	antimicrobial	JJ
cord-300872-blycbi4u	694	91	activities	activity	NNS
cord-300872-blycbi4u	694	92	of	of	IN
cord-300872-blycbi4u	694	93	sulfonohydrazide	sulfonohydrazide	NN
cord-300872-blycbi4u	694	94	-	-	HYPH
cord-300872-blycbi4u	694	95	substituted	substitute	VBN
cord-300872-blycbi4u	694	96	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	694	97	derivative	derivative	NN
cord-300872-blycbi4u	694	98	and	and	CC
cord-300872-blycbi4u	694	99	its	-PRON-	PRP$
cord-300872-blycbi4u	694	100	oxinates	oxinate	NNS
cord-300872-blycbi4u	695	1	Bioconjugation	Bioconjugation	NNP
cord-300872-blycbi4u	696	1	Via	via	IN
cord-300872-blycbi4u	696	2	Azide	Azide	NNP
cord-300872-blycbi4u	696	3	-	-	HYPH
cord-300872-blycbi4u	696	4	Staudinger	Staudinger	NNP
cord-300872-blycbi4u	696	5	ligation	ligation	NN
cord-300872-blycbi4u	696	6	:	:	:
cord-300872-blycbi4u	697	1	An	an	DT
cord-300872-blycbi4u	697	2	overview	overview	NN
cord-300872-blycbi4u	697	3	Synthesis	synthesis	NN
cord-300872-blycbi4u	697	4	and	and	CC
cord-300872-blycbi4u	697	5	biological	biological	JJ
cord-300872-blycbi4u	697	6	evaluation	evaluation	NN
cord-300872-blycbi4u	697	7	of	of	IN
cord-300872-blycbi4u	697	8	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	697	9	-	-	HYPH
cord-300872-blycbi4u	697	10	hydrazones	hydrazone	NNS
cord-300872-blycbi4u	697	11	for	for	IN
cord-300872-blycbi4u	697	12	anti	anti	JJ
cord-300872-blycbi4u	697	13	-	-	NNP
cord-300872-blycbi4u	697	14	Hiv-1	Hiv-1	NNP
cord-300872-blycbi4u	697	15	and	and	CC
cord-300872-blycbi4u	697	16	anticancer	anticancer	JJ
cord-300872-blycbi4u	697	17	potential	potential	NN
cord-300872-blycbi4u	697	18	Design	design	NN
cord-300872-blycbi4u	697	19	,	,	,
cord-300872-blycbi4u	697	20	synthesis	synthesis	NN
cord-300872-blycbi4u	697	21	and	and	CC
cord-300872-blycbi4u	697	22	biological	biological	JJ
cord-300872-blycbi4u	697	23	evaluation	evaluation	NN
cord-300872-blycbi4u	697	24	of	of	IN
cord-300872-blycbi4u	697	25	2-substituted	2-substituted	CD
cord-300872-blycbi4u	697	26	quinolines	quinoline	NNS
cord-300872-blycbi4u	697	27	as	as	IN
cord-300872-blycbi4u	697	28	potential	potential	JJ
cord-300872-blycbi4u	697	29	antileishmanial	antileishmanial	JJ
cord-300872-blycbi4u	697	30	agents	agent	NNS
cord-300872-blycbi4u	697	31	Design	Design	NNP
cord-300872-blycbi4u	697	32	,	,	,
cord-300872-blycbi4u	697	33	synthesis	synthesis	NN
cord-300872-blycbi4u	697	34	and	and	CC
cord-300872-blycbi4u	697	35	biological	biological	JJ
cord-300872-blycbi4u	697	36	evaluation	evaluation	NN
cord-300872-blycbi4u	697	37	of	of	IN
cord-300872-blycbi4u	697	38	1	1	CD
cord-300872-blycbi4u	697	39	,	,	,
cord-300872-blycbi4u	697	40	3	3	CD
cord-300872-blycbi4u	697	41	,	,	,
cord-300872-blycbi4u	697	42	6-trisubstituted	6-trisubstituted	CD
cord-300872-blycbi4u	697	43	B	b	NN
cord-300872-blycbi4u	697	44	-	-	HYPH
cord-300872-blycbi4u	697	45	carboline	carboline	NN
cord-300872-blycbi4u	697	46	derivatives	derivative	NNS
cord-300872-blycbi4u	697	47	for	for	IN
cord-300872-blycbi4u	697	48	cytotoxic	cytotoxic	JJ
cord-300872-blycbi4u	697	49	and	and	CC
cord-300872-blycbi4u	697	50	anti	anti	JJ
cord-300872-blycbi4u	697	51	-	-	JJ
cord-300872-blycbi4u	697	52	Leishmanial	leishmanial	JJ
cord-300872-blycbi4u	697	53	potential	potential	JJ
cord-300872-blycbi4u	697	54	Co	co	NN
cord-300872-blycbi4u	697	55	-	-	HYPH
cord-300872-blycbi4u	697	56	Delivery	Delivery	NNP
cord-300872-blycbi4u	697	57	of	of	IN
cord-300872-blycbi4u	697	58	Docetaxel	Docetaxel	NNP
cord-300872-blycbi4u	697	59	and	and	CC
cord-300872-blycbi4u	697	60	Gemcitabine	Gemcitabine	NNP
cord-300872-blycbi4u	697	61	by	by	IN
cord-300872-blycbi4u	697	62	Anacardic	Anacardic	NNP
cord-300872-blycbi4u	697	63	acid	acid	NN
cord-300872-blycbi4u	697	64	modified	modify	VBN
cord-300872-blycbi4u	697	65	self	self	NN
cord-300872-blycbi4u	697	66	-	-	HYPH
cord-300872-blycbi4u	697	67	assembled	assemble	VBN
cord-300872-blycbi4u	697	68	Albumin	albumin	NN
cord-300872-blycbi4u	697	69	nanoparticles	nanoparticle	NNS
cord-300872-blycbi4u	697	70	for	for	IN
cord-300872-blycbi4u	697	71	effective	effective	JJ
cord-300872-blycbi4u	697	72	Breast	Breast	NNP
cord-300872-blycbi4u	697	73	cancer	cancer	NN
cord-300872-blycbi4u	697	74	management	management	NN
cord-300872-blycbi4u	697	75	Novel	Novel	NNP
cord-300872-blycbi4u	697	76	Gemcitabine	Gemcitabine	NNP
cord-300872-blycbi4u	697	77	conjugated	conjugate	VBD
cord-300872-blycbi4u	697	78	Albumin	albumin	NN
cord-300872-blycbi4u	697	79	nanoparticles	nanoparticle	NNS
cord-300872-blycbi4u	697	80	:	:	:
cord-300872-blycbi4u	698	1	A	a	DT
cord-300872-blycbi4u	698	2	potential	potential	JJ
cord-300872-blycbi4u	698	3	strategy	strategy	NN
cord-300872-blycbi4u	698	4	to	to	TO
cord-300872-blycbi4u	698	5	enhance	enhance	VB
cord-300872-blycbi4u	698	6	drug	drug	NN
cord-300872-blycbi4u	698	7	efficacy	efficacy	NN
cord-300872-blycbi4u	698	8	in	in	IN
cord-300872-blycbi4u	698	9	pancreatic	pancreatic	JJ
cord-300872-blycbi4u	698	10	cancer	cancer	NN
cord-300872-blycbi4u	698	11	treatment	treatment	NN
cord-300872-blycbi4u	698	12	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	698	13	of	of	IN
cord-300872-blycbi4u	698	14	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	698	15	glycoconjugates	glycoconjugate	NNS
cord-300872-blycbi4u	698	16	and	and	CC
cord-300872-blycbi4u	698	17	preliminary	preliminary	JJ
cord-300872-blycbi4u	698	18	assay	assay	NN
cord-300872-blycbi4u	698	19	of	of	IN
cord-300872-blycbi4u	698	20	their	-PRON-	PRP$
cord-300872-blycbi4u	698	21	B1,4-Galt	B1,4-Galt	NNP
cord-300872-blycbi4u	698	22	inhibitory	inhibitory	JJ
cord-300872-blycbi4u	698	23	and	and	CC
cord-300872-blycbi4u	698	24	anti	anti	JJ
cord-300872-blycbi4u	698	25	-	-	JJ
cord-300872-blycbi4u	698	26	cancer	cancer	JJ
cord-300872-blycbi4u	698	27	properties	property	NNS
cord-300872-blycbi4u	698	28	Synthesis	synthesis	NN
cord-300872-blycbi4u	698	29	and	and	CC
cord-300872-blycbi4u	698	30	characterization	characterization	NN
cord-300872-blycbi4u	698	31	of	of	IN
cord-300872-blycbi4u	698	32	a	a	DT
cord-300872-blycbi4u	698	33	new	new	JJ
cord-300872-blycbi4u	698	34	cationic	cationic	JJ
cord-300872-blycbi4u	698	35	galactolipid	galactolipid	NN
cord-300872-blycbi4u	698	36	with	with	IN
cord-300872-blycbi4u	698	37	carbamate	carbamate	NN
cord-300872-blycbi4u	698	38	for	for	IN
cord-300872-blycbi4u	698	39	gene	gene	NN
cord-300872-blycbi4u	698	40	delivery	delivery	NN
cord-300872-blycbi4u	698	41	Click'assembly	click'assembly	RB
cord-300872-blycbi4u	698	42	of	of	IN
cord-300872-blycbi4u	698	43	glycoclusters	glycoclusters	NNP
cord-300872-blycbi4u	698	44	and	and	CC
cord-300872-blycbi4u	698	45	discovery	discovery	NN
cord-300872-blycbi4u	698	46	of	of	IN
cord-300872-blycbi4u	698	47	a	a	DT
cord-300872-blycbi4u	698	48	trehalose	trehalose	JJ
cord-300872-blycbi4u	698	49	analogue	analogue	NN
cord-300872-blycbi4u	698	50	that	that	WDT
cord-300872-blycbi4u	698	51	retards	retard	VBZ
cord-300872-blycbi4u	698	52	Aβ40	Aβ40	NNP
cord-300872-blycbi4u	698	53	aggregation	aggregation	NN
cord-300872-blycbi4u	698	54	and	and	CC
cord-300872-blycbi4u	698	55	inhibits	inhibit	VBZ
cord-300872-blycbi4u	698	56	Aβ40-induced	aβ40-induced	JJ
cord-300872-blycbi4u	698	57	neurotoxicity	neurotoxicity	NN
cord-300872-blycbi4u	699	1	Chemoselective	chemoselective	JJ
cord-300872-blycbi4u	699	2	ligation	ligation	NN
cord-300872-blycbi4u	699	3	of	of	IN
cord-300872-blycbi4u	699	4	maleimidosugars	maleimidosugar	NNS
cord-300872-blycbi4u	699	5	to	to	IN
cord-300872-blycbi4u	699	6	peptides	peptide	NNS
cord-300872-blycbi4u	699	7	/	/	SYM
cord-300872-blycbi4u	699	8	protein	protein	NN
cord-300872-blycbi4u	699	9	for	for	IN
cord-300872-blycbi4u	699	10	the	the	DT
cord-300872-blycbi4u	699	11	preparation	preparation	NN
cord-300872-blycbi4u	699	12	of	of	IN
cord-300872-blycbi4u	699	13	neoglycopeptides/	neoglycopeptides/	CD
cord-300872-blycbi4u	700	1	neoglycoprotein	neoglycoprotein	NNP
cord-300872-blycbi4u	700	2	Halogenated	Halogenated	NNP
cord-300872-blycbi4u	700	3	2-amino-4h	2-amino-4h	NNP
cord-300872-blycbi4u	700	4	-	-	HYPH
cord-300872-blycbi4u	700	5	pyrano	pyrano	NNP
cord-300872-blycbi4u	701	1	[	[	-LRB-
cord-300872-blycbi4u	701	2	3,2-H	3,2-h	CD
cord-300872-blycbi4u	701	3	]	]	-RRB-
cord-300872-blycbi4u	701	4	quinoline-3-carbonitriles	quinoline-3-carbonitriles	NNPS
cord-300872-blycbi4u	701	5	as	as	IN
cord-300872-blycbi4u	701	6	antitumor	antitumor	JJ
cord-300872-blycbi4u	701	7	agents	agent	NNS
cord-300872-blycbi4u	701	8	and	and	CC
cord-300872-blycbi4u	701	9	structure	structure	NN
cord-300872-blycbi4u	701	10	-	-	HYPH
cord-300872-blycbi4u	701	11	activity	activity	NN
cord-300872-blycbi4u	701	12	relationships	relationship	NNS
cord-300872-blycbi4u	701	13	of	of	IN
cord-300872-blycbi4u	701	14	the	the	DT
cord-300872-blycbi4u	701	15	4-	4-	NNP
cord-300872-blycbi4u	701	16	,	,	,
cord-300872-blycbi4u	701	17	6-	6-	UH
cord-300872-blycbi4u	701	18	,	,	,
cord-300872-blycbi4u	701	19	and	and	CC
cord-300872-blycbi4u	701	20	9-positions	9-positions	CD
cord-300872-blycbi4u	701	21	Amberlite	Amberlite	NNP
cord-300872-blycbi4u	701	22	Ira	Ira	NNP
cord-300872-blycbi4u	701	23	402	402	CD
cord-300872-blycbi4u	702	1	(	(	-LRB-
cord-300872-blycbi4u	702	2	Oh	oh	UH
cord-300872-blycbi4u	702	3	)	)	-RRB-
cord-300872-blycbi4u	702	4	mediated	mediate	VBN
cord-300872-blycbi4u	702	5	green	green	JJ
cord-300872-blycbi4u	702	6	synthesis	synthesis	NN
cord-300872-blycbi4u	702	7	of	of	IN
cord-300872-blycbi4u	702	8	novel	novel	JJ
cord-300872-blycbi4u	702	9	benzothiazole	benzothiazole	NNP
cord-300872-blycbi4u	702	10	-	-	HYPH
cord-300872-blycbi4u	702	11	quinoline	quinoline	NN
cord-300872-blycbi4u	702	12	conjugates	conjugate	NNS
cord-300872-blycbi4u	702	13	as	as	IN
cord-300872-blycbi4u	702	14	cancer	cancer	NN
cord-300872-blycbi4u	702	15	theranostics	theranostic	NNS
cord-300872-blycbi4u	703	1	Comparative	comparative	JJ
cord-300872-blycbi4u	703	2	theoretical	theoretical	JJ
cord-300872-blycbi4u	703	3	and	and	CC
cord-300872-blycbi4u	703	4	experimental	experimental	JJ
cord-300872-blycbi4u	703	5	study	study	NN
cord-300872-blycbi4u	703	6	on	on	IN
cord-300872-blycbi4u	703	7	novel	novel	JJ
cord-300872-blycbi4u	703	8	tri	tri	JJ
cord-300872-blycbi4u	703	9	-	-	JJ
cord-300872-blycbi4u	703	10	quinoline	quinoline	JJ
cord-300872-blycbi4u	703	11	system	system	NN
cord-300872-blycbi4u	703	12	and	and	CC
cord-300872-blycbi4u	703	13	its	-PRON-	PRP$
cord-300872-blycbi4u	703	14	anticancer	anticancer	JJ
cord-300872-blycbi4u	703	15	studies	study	NNS
cord-300872-blycbi4u	703	16	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	703	17	,	,	,
cord-300872-blycbi4u	703	18	anticancer	anticancer	JJ
cord-300872-blycbi4u	703	19	evaluation	evaluation	NN
cord-300872-blycbi4u	703	20	and	and	CC
cord-300872-blycbi4u	703	21	DNA	dna	NN
cord-300872-blycbi4u	703	22	-	-	HYPH
cord-300872-blycbi4u	703	23	binding	bind	VBG
cord-300872-blycbi4u	703	24	spectroscopic	spectroscopic	JJ
cord-300872-blycbi4u	703	25	insights	insight	NNS
cord-300872-blycbi4u	703	26	of	of	IN
cord-300872-blycbi4u	703	27	quinoline	quinoline	NN
cord-300872-blycbi4u	703	28	-	-	HYPH
cord-300872-blycbi4u	703	29	based	base	VBN
cord-300872-blycbi4u	703	30	1	1	CD
cord-300872-blycbi4u	703	31	,	,	,
cord-300872-blycbi4u	703	32	3	3	CD
cord-300872-blycbi4u	703	33	,	,	,
cord-300872-blycbi4u	703	34	4-oxadiazole-1	4-oxadiazole-1	CD
cord-300872-blycbi4u	703	35	,	,	,
cord-300872-blycbi4u	703	36	2	2	CD
cord-300872-blycbi4u	703	37	,	,	,
cord-300872-blycbi4u	703	38	3-triazole	3-triazole	CD
cord-300872-blycbi4u	703	39	conjugates	conjugate	VBZ
cord-300872-blycbi4u	703	40	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	703	41	and	and	CC
cord-300872-blycbi4u	703	42	anti	anti	JJ
cord-300872-blycbi4u	703	43	-	-	JJ
cord-300872-blycbi4u	703	44	breast	breast	JJ
cord-300872-blycbi4u	703	45	cancer	cancer	NN
cord-300872-blycbi4u	703	46	activities	activity	NNS
cord-300872-blycbi4u	703	47	of	of	IN
cord-300872-blycbi4u	703	48	substituted	substitute	VBN
cord-300872-blycbi4u	703	49	quinolines	quinoline	NNS
cord-300872-blycbi4u	703	50	Design	Design	NNP
cord-300872-blycbi4u	703	51	,	,	,
cord-300872-blycbi4u	703	52	synthesis	synthesis	NN
cord-300872-blycbi4u	703	53	and	and	CC
cord-300872-blycbi4u	703	54	biological	biological	JJ
cord-300872-blycbi4u	703	55	evaluation	evaluation	NN
cord-300872-blycbi4u	703	56	of	of	IN
cord-300872-blycbi4u	703	57	new	new	JJ
cord-300872-blycbi4u	703	58	4-(4-substituted	4-(4-substituted	CD
cord-300872-blycbi4u	703	59	-	-	HYPH
cord-300872-blycbi4u	703	60	anilino	anilino	NNS
cord-300872-blycbi4u	703	61	)	)	-RRB-
cord-300872-blycbi4u	704	1	quinoline	quinoline	JJ
cord-300872-blycbi4u	704	2	derivatives	derivative	NNS
cord-300872-blycbi4u	704	3	as	as	IN
cord-300872-blycbi4u	704	4	anticancer	anticancer	JJ
cord-300872-blycbi4u	704	5	agents	agent	NNS
cord-300872-blycbi4u	705	1	The	the	DT
cord-300872-blycbi4u	705	2	synthesis	synthesis	NN
cord-300872-blycbi4u	705	3	and	and	CC
cord-300872-blycbi4u	705	4	anticancer	anticancer	JJ
cord-300872-blycbi4u	705	5	activity	activity	NN
cord-300872-blycbi4u	705	6	of	of	IN
cord-300872-blycbi4u	705	7	2-styrylquinoline	2-styrylquinoline	CD
cord-300872-blycbi4u	705	8	derivatives	derivative	NNS
cord-300872-blycbi4u	705	9	.	.	.
cord-300872-blycbi4u	706	1	A	a	DT
cord-300872-blycbi4u	706	2	P53	P53	NNP
cord-300872-blycbi4u	706	3	independent	independent	JJ
cord-300872-blycbi4u	706	4	mechanism	mechanism	NN
cord-300872-blycbi4u	706	5	of	of	IN
cord-300872-blycbi4u	706	6	action	action	NN
cord-300872-blycbi4u	707	1	An	an	DT
cord-300872-blycbi4u	707	2	efficient	efficient	JJ
cord-300872-blycbi4u	707	3	microwave	microwave	NN
cord-300872-blycbi4u	707	4	-	-	HYPH
cord-300872-blycbi4u	707	5	assisted	assist	VBN
cord-300872-blycbi4u	707	6	synthesis	synthesis	NN
cord-300872-blycbi4u	707	7	of	of	IN
cord-300872-blycbi4u	707	8	structurally	structurally	RB
cord-300872-blycbi4u	707	9	diverse	diverse	JJ
cord-300872-blycbi4u	707	10	styrylquinolines	styrylquinoline	NNS
cord-300872-blycbi4u	707	11	New	new	JJ
cord-300872-blycbi4u	707	12	pyranoquinoline	pyranoquinoline	NN
cord-300872-blycbi4u	707	13	derivatives	derivative	NNS
cord-300872-blycbi4u	707	14	as	as	IN
cord-300872-blycbi4u	707	15	vascular	vascular	JJ
cord-300872-blycbi4u	707	16	-	-	HYPH
cord-300872-blycbi4u	707	17	disrupting	disrupt	VBG
cord-300872-blycbi4u	707	18	anticancer	anticancer	JJ
cord-300872-blycbi4u	707	19	agents	agent	NNS
cord-300872-blycbi4u	707	20	Matrix	Matrix	NNP
cord-300872-blycbi4u	707	21	metalloproteinase-7	metalloproteinase-7	NNP
cord-300872-blycbi4u	707	22	degrades	degrade	VBZ
cord-300872-blycbi4u	707	23	all	all	DT
cord-300872-blycbi4u	707	24	insulin	insulin	NN
cord-300872-blycbi4u	707	25	-	-	HYPH
cord-300872-blycbi4u	707	26	like	like	JJ
cord-300872-blycbi4u	707	27	growth	growth	NN
cord-300872-blycbi4u	707	28	factor	factor	NN
cord-300872-blycbi4u	707	29	binding	bind	VBG
cord-300872-blycbi4u	707	30	proteins	protein	NNS
cord-300872-blycbi4u	707	31	and	and	CC
cord-300872-blycbi4u	707	32	facilitates	facilitate	VBZ
cord-300872-blycbi4u	707	33	insulin	insulin	NN
cord-300872-blycbi4u	707	34	-	-	HYPH
cord-300872-blycbi4u	707	35	like	like	JJ
cord-300872-blycbi4u	707	36	growth	growth	NN
cord-300872-blycbi4u	707	37	factor	factor	NN
cord-300872-blycbi4u	707	38	bioavailability	bioavailability	NN
cord-300872-blycbi4u	707	39	Review	Review	NNP
cord-300872-blycbi4u	707	40	on	on	IN
cord-300872-blycbi4u	707	41	Epidermal	epidermal	JJ
cord-300872-blycbi4u	707	42	growth	growth	NN
cord-300872-blycbi4u	707	43	factor	factor	NN
cord-300872-blycbi4u	707	44	receptor	receptor	NN
cord-300872-blycbi4u	707	45	(	(	-LRB-
cord-300872-blycbi4u	707	46	Egfr	Egfr	NNP
cord-300872-blycbi4u	707	47	)	)	-RRB-
cord-300872-blycbi4u	707	48	structure	structure	NN
cord-300872-blycbi4u	707	49	,	,	,
cord-300872-blycbi4u	707	50	signaling	signal	VBG
cord-300872-blycbi4u	707	51	pathways	pathway	NNS
cord-300872-blycbi4u	707	52	,	,	,
cord-300872-blycbi4u	707	53	interactions	interaction	NNS
cord-300872-blycbi4u	707	54	,	,	,
cord-300872-blycbi4u	707	55	and	and	CC
cord-300872-blycbi4u	707	56	recent	recent	JJ
cord-300872-blycbi4u	707	57	updates	update	NNS
cord-300872-blycbi4u	707	58	of	of	IN
cord-300872-blycbi4u	707	59	Egfr	Egfr	NNP
cord-300872-blycbi4u	707	60	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	707	61	Design	Design	NNP
cord-300872-blycbi4u	707	62	,	,	,
cord-300872-blycbi4u	707	63	synthesis	synthesis	NN
cord-300872-blycbi4u	707	64	and	and	CC
cord-300872-blycbi4u	707	65	preliminary	preliminary	JJ
cord-300872-blycbi4u	707	66	bioactivity	bioactivity	NN
cord-300872-blycbi4u	707	67	evaluations	evaluation	NNS
cord-300872-blycbi4u	707	68	of	of	IN
cord-300872-blycbi4u	707	69	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	707	70	derivatives	derivative	NNS
cord-300872-blycbi4u	707	71	as	as	IN
cord-300872-blycbi4u	707	72	Matrix	Matrix	NNP
cord-300872-blycbi4u	707	73	metalloproteinase	metalloproteinase	NN
cord-300872-blycbi4u	707	74	(	(	-LRB-
cord-300872-blycbi4u	707	75	Mmp	Mmp	NNP
cord-300872-blycbi4u	707	76	)	)	-RRB-
cord-300872-blycbi4u	707	77	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	707	78	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	707	79	of	of	IN
cord-300872-blycbi4u	707	80	tetracyclic	tetracyclic	NNP
cord-300872-blycbi4u	707	81	pyrrolidine	pyrrolidine	NNP
cord-300872-blycbi4u	707	82	/	/	SYM
cord-300872-blycbi4u	707	83	isoxazolidine	isoxazolidine	JJ
cord-300872-blycbi4u	707	84	fused	fuse	VBN
cord-300872-blycbi4u	707	85	pyrano	pyrano	NNP
cord-300872-blycbi4u	707	86	[	[	-LRB-
cord-300872-blycbi4u	707	87	3,2-H	3,2-h	CD
cord-300872-blycbi4u	707	88	]	]	-RRB-
cord-300872-blycbi4u	707	89	quinolines	quinoline	NNS
cord-300872-blycbi4u	707	90	via	via	IN
cord-300872-blycbi4u	707	91	intramolecular	intramolecular	JJ
cord-300872-blycbi4u	707	92	1,3-dipolar	1,3-dipolar	CD
cord-300872-blycbi4u	707	93	cycloaddition	cycloaddition	NN
cord-300872-blycbi4u	707	94	in	in	IN
cord-300872-blycbi4u	707	95	ionic	ionic	JJ
cord-300872-blycbi4u	707	96	liquid	liquid	JJ
cord-300872-blycbi4u	707	97	Discovery	Discovery	NNP
cord-300872-blycbi4u	707	98	of	of	IN
cord-300872-blycbi4u	707	99	Cgs	Cgs	NNP
cord-300872-blycbi4u	707	100	27023a	27023a	CD
cord-300872-blycbi4u	707	101	,	,	,
cord-300872-blycbi4u	707	102	a	a	DT
cord-300872-blycbi4u	707	103	non	non	JJ
cord-300872-blycbi4u	707	104	-	-	JJ
cord-300872-blycbi4u	707	105	peptidic	peptidic	JJ
cord-300872-blycbi4u	707	106	,	,	,
cord-300872-blycbi4u	707	107	potent	potent	JJ
cord-300872-blycbi4u	707	108	,	,	,
cord-300872-blycbi4u	707	109	and	and	CC
cord-300872-blycbi4u	707	110	orally	orally	RB
cord-300872-blycbi4u	707	111	active	active	JJ
cord-300872-blycbi4u	707	112	stromelysin	stromelysin	NNP
cord-300872-blycbi4u	707	113	inhibitor	inhibitor	NN
cord-300872-blycbi4u	707	114	that	that	WDT
cord-300872-blycbi4u	707	115	blocks	block	VBZ
cord-300872-blycbi4u	707	116	cartilage	cartilage	NN
cord-300872-blycbi4u	707	117	degradation	degradation	NN
cord-300872-blycbi4u	707	118	in	in	IN
cord-300872-blycbi4u	707	119	rabbits	rabbit	NNS
cord-300872-blycbi4u	707	120	Quinoline	Quinoline	NNP
cord-300872-blycbi4u	707	121	-	-	HYPH
cord-300872-blycbi4u	707	122	Based	base	VBN
cord-300872-blycbi4u	707	123	promising	promising	JJ
cord-300872-blycbi4u	707	124	anticancer	anticancer	NN
cord-300872-blycbi4u	707	125	and	and	CC
cord-300872-blycbi4u	707	126	antibacterial	antibacterial	JJ
cord-300872-blycbi4u	707	127	agents	agent	NNS
cord-300872-blycbi4u	707	128	,	,	,
cord-300872-blycbi4u	707	129	and	and	CC
cord-300872-blycbi4u	707	130	some	some	DT
cord-300872-blycbi4u	707	131	metabolic	metabolic	JJ
cord-300872-blycbi4u	707	132	enzyme	enzyme	NN
cord-300872-blycbi4u	707	133	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	707	134	Acetylcholinesterase	Acetylcholinesterase	NNP
cord-300872-blycbi4u	707	135	inhibition	inhibition	NN
cord-300872-blycbi4u	707	136	by	by	IN
cord-300872-blycbi4u	707	137	flavonoids	flavonoid	NNS
cord-300872-blycbi4u	707	138	from	from	IN
cord-300872-blycbi4u	707	139	Agrimonia	Agrimonia	NNP
cord-300872-blycbi4u	708	1	pilosa	pilosa	NNP
cord-300872-blycbi4u	708	2	Coumarin	Coumarin	NNP
cord-300872-blycbi4u	708	3	derivatives	derivative	NNS
cord-300872-blycbi4u	708	4	as	as	IN
cord-300872-blycbi4u	708	5	acetyl	acetyl	NN
cord-300872-blycbi4u	708	6	-	-	:
cord-300872-blycbi4u	708	7	and	and	CC
cord-300872-blycbi4u	708	8	butyrylcholinestrase	butyrylcholinestrase	NN
cord-300872-blycbi4u	708	9	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	708	10	:	:	:
cord-300872-blycbi4u	709	1	An	an	DT
cord-300872-blycbi4u	709	2	In	in	IN
cord-300872-blycbi4u	709	3	Vitro	Vitro	NNP
cord-300872-blycbi4u	709	4	,	,	,
cord-300872-blycbi4u	709	5	molecular	molecular	JJ
cord-300872-blycbi4u	709	6	docking	docking	NN
cord-300872-blycbi4u	709	7	,	,	,
cord-300872-blycbi4u	709	8	and	and	CC
cord-300872-blycbi4u	709	9	molecular	molecular	JJ
cord-300872-blycbi4u	709	10	dynamics	dynamic	NNS
cord-300872-blycbi4u	709	11	simulations	simulation	NNS
cord-300872-blycbi4u	709	12	study	study	VBP
cord-300872-blycbi4u	709	13	Cholinesterase	Cholinesterase	NNP
cord-300872-blycbi4u	709	14	inhibitors	inhibitor	NNS
cord-300872-blycbi4u	709	15	and	and	CC
cord-300872-blycbi4u	709	16	beyond	beyond	IN
cord-300872-blycbi4u	709	17	Pet	Pet	NNP
cord-300872-blycbi4u	709	18	imaging	imaging	NN
cord-300872-blycbi4u	709	19	of	of	IN
cord-300872-blycbi4u	709	20	copper	copper	NN
cord-300872-blycbi4u	709	21	trafficking	trafficking	NN
cord-300872-blycbi4u	709	22	in	in	IN
cord-300872-blycbi4u	709	23	a	a	DT
cord-300872-blycbi4u	709	24	mouse	mouse	NN
cord-300872-blycbi4u	709	25	model	model	NN
cord-300872-blycbi4u	709	26	of	of	IN
cord-300872-blycbi4u	709	27	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	709	28	disease	disease	NN
cord-300872-blycbi4u	709	29	Nanoprobing	Nanoprobing	NNP
cord-300872-blycbi4u	709	30	of	of	IN
cord-300872-blycbi4u	709	31	the	the	DT
cord-300872-blycbi4u	709	32	effect	effect	NN
cord-300872-blycbi4u	709	33	of	of	IN
cord-300872-blycbi4u	709	34	Cu	Cu	NNP
cord-300872-blycbi4u	709	35	2	2	CD
cord-300872-blycbi4u	709	36	+	+	SYM
cord-300872-blycbi4u	709	37	cations	cation	NNS
cord-300872-blycbi4u	709	38	on	on	IN
cord-300872-blycbi4u	709	39	misfolding	misfolde	VBG
cord-300872-blycbi4u	709	40	,	,	,
cord-300872-blycbi4u	709	41	interaction	interaction	NN
cord-300872-blycbi4u	709	42	and	and	CC
cord-300872-blycbi4u	709	43	aggregation	aggregation	NN
cord-300872-blycbi4u	709	44	of	of	IN
cord-300872-blycbi4u	709	45	Amyloid	Amyloid	NNP
cord-300872-blycbi4u	709	46	B	B	NNP
cord-300872-blycbi4u	709	47	peptide	peptide	NN
cord-300872-blycbi4u	709	48	Coumarin	Coumarin	NNP
cord-300872-blycbi4u	709	49	derivatives	derivative	NNS
cord-300872-blycbi4u	709	50	bearing	bear	VBG
cord-300872-blycbi4u	709	51	benzoheterocycle	benzoheterocycle	NNP
cord-300872-blycbi4u	709	52	moiety	moiety	NN
cord-300872-blycbi4u	709	53	:	:	:
cord-300872-blycbi4u	710	1	Synthesis	synthesis	NN
cord-300872-blycbi4u	710	2	,	,	,
cord-300872-blycbi4u	710	3	cholinesterase	cholinesterase	NN
cord-300872-blycbi4u	710	4	inhibitory	inhibitory	NN
cord-300872-blycbi4u	710	5	,	,	,
cord-300872-blycbi4u	710	6	and	and	CC
cord-300872-blycbi4u	710	7	docking	dock	VBG
cord-300872-blycbi4u	710	8	simulation	simulation	NN
cord-300872-blycbi4u	710	9	study	study	NN
cord-300872-blycbi4u	710	10	Novel	Novel	NNP
cord-300872-blycbi4u	710	11	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	710	12	derivatives	derivative	NNS
cord-300872-blycbi4u	710	13	targeting	target	VBG
cord-300872-blycbi4u	710	14	B	B	NNP
cord-300872-blycbi4u	710	15	-	-	HYPH
cord-300872-blycbi4u	710	16	Amyloid	Amyloid	NNP
cord-300872-blycbi4u	710	17	aggregation	aggregation	NN
cord-300872-blycbi4u	710	18	,	,	,
cord-300872-blycbi4u	710	19	metal	metal	NN
cord-300872-blycbi4u	710	20	chelation	chelation	NN
cord-300872-blycbi4u	710	21	and	and	CC
cord-300872-blycbi4u	710	22	oxidative	oxidative	JJ
cord-300872-blycbi4u	710	23	stress	stress	NN
cord-300872-blycbi4u	710	24	AGAINST	against	IN
cord-300872-blycbi4u	710	25	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	26	's	's	POS
cord-300872-blycbi4u	710	27	disease	disease	NN
cord-300872-blycbi4u	710	28	Design	design	NN
cord-300872-blycbi4u	710	29	,	,	,
cord-300872-blycbi4u	710	30	synthesis	synthesis	NN
cord-300872-blycbi4u	710	31	,	,	,
cord-300872-blycbi4u	710	32	and	and	CC
cord-300872-blycbi4u	710	33	evaluation	evaluation	NN
cord-300872-blycbi4u	710	34	of	of	IN
cord-300872-blycbi4u	710	35	multitarget	multitarget	NN
cord-300872-blycbi4u	710	36	-	-	HYPH
cord-300872-blycbi4u	710	37	directed	direct	VBN
cord-300872-blycbi4u	710	38	resveratrol	resveratrol	NN
cord-300872-blycbi4u	710	39	derivatives	derivative	NNS
cord-300872-blycbi4u	710	40	for	for	IN
cord-300872-blycbi4u	710	41	the	the	DT
cord-300872-blycbi4u	710	42	treatment	treatment	NN
cord-300872-blycbi4u	710	43	of	of	IN
cord-300872-blycbi4u	710	44	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	45	's	's	POS
cord-300872-blycbi4u	710	46	disease	disease	NN
cord-300872-blycbi4u	710	47	Design	design	NN
cord-300872-blycbi4u	710	48	,	,	,
cord-300872-blycbi4u	710	49	synthesis	synthesis	NN
cord-300872-blycbi4u	710	50	,	,	,
cord-300872-blycbi4u	710	51	and	and	CC
cord-300872-blycbi4u	710	52	evaluation	evaluation	NN
cord-300872-blycbi4u	710	53	of	of	IN
cord-300872-blycbi4u	710	54	orally	orally	RB
cord-300872-blycbi4u	710	55	available	available	JJ
cord-300872-blycbi4u	710	56	Clioquinol	Clioquinol	NNP
cord-300872-blycbi4u	710	57	-	-	HYPH
cord-300872-blycbi4u	710	58	Moracin	Moracin	NNP
cord-300872-blycbi4u	710	59	M	M	NNP
cord-300872-blycbi4u	710	60	hybrids	hybrid	NNS
cord-300872-blycbi4u	710	61	as	as	IN
cord-300872-blycbi4u	710	62	multitarget	multitarget	NN
cord-300872-blycbi4u	710	63	-	-	HYPH
cord-300872-blycbi4u	710	64	directed	direct	VBN
cord-300872-blycbi4u	710	65	ligands	ligand	NNS
cord-300872-blycbi4u	710	66	for	for	IN
cord-300872-blycbi4u	710	67	cognitive	cognitive	JJ
cord-300872-blycbi4u	710	68	improvement	improvement	NN
cord-300872-blycbi4u	710	69	in	in	IN
cord-300872-blycbi4u	710	70	a	a	DT
cord-300872-blycbi4u	710	71	rat	rat	NN
cord-300872-blycbi4u	710	72	model	model	NN
cord-300872-blycbi4u	710	73	of	of	IN
cord-300872-blycbi4u	710	74	neurodegeneration	neurodegeneration	NN
cord-300872-blycbi4u	710	75	in	in	IN
cord-300872-blycbi4u	710	76	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	77	's	's	POS
cord-300872-blycbi4u	710	78	disease	disease	NN
cord-300872-blycbi4u	710	79	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	710	80	and	and	CC
cord-300872-blycbi4u	710	81	evaluation	evaluation	NN
cord-300872-blycbi4u	710	82	of	of	IN
cord-300872-blycbi4u	710	83	clioquinol	clioquinol	NNP
cord-300872-blycbi4u	710	84	-	-	HYPH
cord-300872-blycbi4u	710	85	rolipram	rolipram	NNP
cord-300872-blycbi4u	710	86	/	/	SYM
cord-300872-blycbi4u	710	87	roflumilast	roflumilast	NN
cord-300872-blycbi4u	710	88	hybrids	hybrid	NNS
cord-300872-blycbi4u	710	89	as	as	IN
cord-300872-blycbi4u	710	90	multitarget	multitarget	NN
cord-300872-blycbi4u	710	91	-	-	HYPH
cord-300872-blycbi4u	710	92	directed	direct	VBN
cord-300872-blycbi4u	710	93	ligands	ligand	NNS
cord-300872-blycbi4u	710	94	for	for	IN
cord-300872-blycbi4u	710	95	the	the	DT
cord-300872-blycbi4u	710	96	treatment	treatment	NN
cord-300872-blycbi4u	710	97	of	of	IN
cord-300872-blycbi4u	710	98	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	99	's	's	POS
cord-300872-blycbi4u	710	100	disease	disease	NN
cord-300872-blycbi4u	710	101	Profiling	Profiling	NNP
cord-300872-blycbi4u	710	102	Donepezil	Donepezil	NNP
cord-300872-blycbi4u	710	103	template	template	NN
cord-300872-blycbi4u	710	104	into	into	IN
cord-300872-blycbi4u	710	105	multipotent	multipotent	JJ
cord-300872-blycbi4u	710	106	hybrids	hybrid	NNS
cord-300872-blycbi4u	710	107	with	with	IN
cord-300872-blycbi4u	710	108	antioxidant	antioxidant	JJ
cord-300872-blycbi4u	710	109	properties	property	NNS
cord-300872-blycbi4u	710	110	Antioxidant	antioxidant	NN
cord-300872-blycbi4u	710	111	capacity	capacity	NN
cord-300872-blycbi4u	710	112	in	in	IN
cord-300872-blycbi4u	710	113	the	the	DT
cord-300872-blycbi4u	710	114	lipophilic	lipophilic	JJ
cord-300872-blycbi4u	710	115	fraction	fraction	NN
cord-300872-blycbi4u	710	116	of	of	IN
cord-300872-blycbi4u	710	117	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	118	's	's	POS
cord-300872-blycbi4u	710	119	brain	brain	NN
cord-300872-blycbi4u	710	120	tissues	tissue	VBZ
cord-300872-blycbi4u	710	121	Inflammatory	inflammatory	JJ
cord-300872-blycbi4u	710	122	events	event	NNS
cord-300872-blycbi4u	710	123	at	at	IN
cord-300872-blycbi4u	710	124	blood	blood	NN
cord-300872-blycbi4u	710	125	-	-	HYPH
cord-300872-blycbi4u	710	126	brain	brain	NN
cord-300872-blycbi4u	710	127	barrier	barrier	NN
cord-300872-blycbi4u	710	128	in	in	IN
cord-300872-blycbi4u	710	129	neuroinflammatory	neuroinflammatory	NN
cord-300872-blycbi4u	710	130	and	and	CC
cord-300872-blycbi4u	710	131	neurodegenerative	neurodegenerative	JJ
cord-300872-blycbi4u	710	132	disorders	disorder	NNS
cord-300872-blycbi4u	710	133	:	:	:
cord-300872-blycbi4u	710	134	Implications	implication	NNS
cord-300872-blycbi4u	710	135	for	for	IN
cord-300872-blycbi4u	710	136	clinical	clinical	JJ
cord-300872-blycbi4u	710	137	disease	disease	NN
cord-300872-blycbi4u	710	138	Design	design	NN
cord-300872-blycbi4u	710	139	,	,	,
cord-300872-blycbi4u	710	140	synthesis	synthesis	NN
cord-300872-blycbi4u	710	141	,	,	,
cord-300872-blycbi4u	710	142	and	and	CC
cord-300872-blycbi4u	710	143	evaluation	evaluation	NN
cord-300872-blycbi4u	710	144	of	of	IN
cord-300872-blycbi4u	710	145	orally	orally	RB
cord-300872-blycbi4u	710	146	bioavailable	bioavailable	JJ
cord-300872-blycbi4u	710	147	quinoline	quinoline	JJ
cord-300872-blycbi4u	710	148	-	-	HYPH
cord-300872-blycbi4u	710	149	indole	indole	NN
cord-300872-blycbi4u	710	150	derivatives	derivative	NNS
cord-300872-blycbi4u	710	151	as	as	IN
cord-300872-blycbi4u	710	152	innovative	innovative	JJ
cord-300872-blycbi4u	710	153	multitarget	multitarget	NN
cord-300872-blycbi4u	710	154	-	-	HYPH
cord-300872-blycbi4u	710	155	directed	direct	VBN
cord-300872-blycbi4u	710	156	ligands	ligand	NNS
cord-300872-blycbi4u	710	157	:	:	:
cord-300872-blycbi4u	710	158	Promotion	promotion	NN
cord-300872-blycbi4u	710	159	of	of	IN
cord-300872-blycbi4u	710	160	cell	cell	NN
cord-300872-blycbi4u	710	161	proliferation	proliferation	NN
cord-300872-blycbi4u	710	162	in	in	IN
cord-300872-blycbi4u	710	163	the	the	DT
cord-300872-blycbi4u	710	164	adult	adult	NN
cord-300872-blycbi4u	710	165	murine	murine	JJ
cord-300872-blycbi4u	710	166	hippocampus	hippocampus	NN
cord-300872-blycbi4u	710	167	for	for	IN
cord-300872-blycbi4u	710	168	the	the	DT
cord-300872-blycbi4u	710	169	treatment	treatment	NN
cord-300872-blycbi4u	710	170	of	of	IN
cord-300872-blycbi4u	710	171	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	710	172	's	's	POS
cord-300872-blycbi4u	710	173	disease	disease	NN
cord-300872-blycbi4u	711	1	The	the	DT
cord-300872-blycbi4u	711	2	amyloid	amyloid	NN
cord-300872-blycbi4u	711	3	beta	beta	NN
cord-300872-blycbi4u	711	4	peptide	peptide	NN
cord-300872-blycbi4u	711	5	:	:	:
cord-300872-blycbi4u	711	6	A	a	DT
cord-300872-blycbi4u	711	7	chemist	chemist	NN
cord-300872-blycbi4u	711	8	's	's	POS
cord-300872-blycbi4u	711	9	perspective	perspective	NN
cord-300872-blycbi4u	711	10	.	.	.
cord-300872-blycbi4u	712	1	Role	role	NN
cord-300872-blycbi4u	712	2	in	in	IN
cord-300872-blycbi4u	712	3	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	712	4	's	's	POS
cord-300872-blycbi4u	712	5	and	and	CC
cord-300872-blycbi4u	712	6	fibrillization	fibrillization	NN
cord-300872-blycbi4u	712	7	Novel	Novel	NNP
cord-300872-blycbi4u	712	8	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	712	9	derivatives	derivative	NNS
cord-300872-blycbi4u	712	10	as	as	IN
cord-300872-blycbi4u	712	11	multitarget	multitarget	NN
cord-300872-blycbi4u	712	12	compounds	compound	NNS
cord-300872-blycbi4u	712	13	for	for	IN
cord-300872-blycbi4u	712	14	the	the	DT
cord-300872-blycbi4u	712	15	treatment	treatment	NN
cord-300872-blycbi4u	712	16	of	of	IN
cord-300872-blycbi4u	712	17	Alzheimer	Alzheimer	NNP
cord-300872-blycbi4u	712	18	's	's	POS
cord-300872-blycbi4u	712	19	disease	disease	NN
cord-300872-blycbi4u	712	20	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	712	21	,	,	,
cord-300872-blycbi4u	712	22	characterization	characterization	NN
cord-300872-blycbi4u	712	23	,	,	,
cord-300872-blycbi4u	712	24	and	and	CC
cord-300872-blycbi4u	712	25	structure	structure	NN
cord-300872-blycbi4u	712	26	of	of	IN
cord-300872-blycbi4u	712	27	quinoline	quinoline	NN
cord-300872-blycbi4u	712	28	-	-	HYPH
cord-300872-blycbi4u	712	29	based	base	VBN
cord-300872-blycbi4u	712	30	benzimidazole	benzimidazole	NNP
cord-300872-blycbi4u	712	31	derivatives	derivative	NNS
cord-300872-blycbi4u	712	32	Synthesis	Synthesis	NNP
cord-300872-blycbi4u	712	33	of	of	IN
cord-300872-blycbi4u	712	34	pyrazolo	pyrazolo	NN
cord-300872-blycbi4u	712	35	-	-	,
cord-300872-blycbi4u	712	36	and	and	CC
cord-300872-blycbi4u	712	37	[	[	-LRB-
cord-300872-blycbi4u	712	38	1,2,4	1,2,4	CD
cord-300872-blycbi4u	712	39	]	]	-RRB-
cord-300872-blycbi4u	712	40	triazolo-[1,5-A	triazolo-[1,5-A	.
cord-300872-blycbi4u	712	41	]	]	-RRB-
cord-300872-blycbi4u	712	42	quinolin-9-ols	quinolin-9-ol	NNS
cord-300872-blycbi4u	712	43	by	by	IN
cord-300872-blycbi4u	712	44	cycloaddition	cycloaddition	NN
cord-300872-blycbi4u	712	45	to	to	IN
cord-300872-blycbi4u	712	46	8-hydroxyquinoline	8-hydroxyquinoline	CD
cord-300872-blycbi4u	712	47	N	n	CD
cord-300872-blycbi4u	712	48	-	-	HYPH
cord-300872-blycbi4u	712	49	imide	imide	NN
cord-300872-blycbi4u	712	50	O	O	NNP
cord-300872-blycbi4u	712	51	-	-	HYPH
cord-300872-blycbi4u	712	52	Mesitylenesulfonylhydroxylamine	Mesitylenesulfonylhydroxylamine	NNP
cord-300872-blycbi4u	712	53	and	and	CC
cord-300872-blycbi4u	712	54	related	related	JJ
cord-300872-blycbi4u	712	55	compounds	compound	NNS
cord-300872-blycbi4u	712	56	-	-	HYPH
cord-300872-blycbi4u	712	57	powerful	powerful	JJ
cord-300872-blycbi4u	712	58	aminating	aminating	NN
cord-300872-blycbi4u	712	59	reagents	reagent	NNS
cord-300872-blycbi4u	713	1	Convenient	convenient	JJ
cord-300872-blycbi4u	713	2	one	one	CD
cord-300872-blycbi4u	713	3	-	-	HYPH
cord-300872-blycbi4u	713	4	pot	pot	NN
cord-300872-blycbi4u	713	5	synthesis	synthesis	NN
cord-300872-blycbi4u	713	6	of	of	IN
cord-300872-blycbi4u	713	7	thiobarbituro	thiobarbituro	NNP
cord-300872-blycbi4u	713	8	-	-	HYPH
cord-300872-blycbi4u	713	9	quinoline	quinoline	JJ
cord-300872-blycbi4u	713	10	derivatives	derivative	NNS
cord-300872-blycbi4u	713	11	via	via	IN
cord-300872-blycbi4u	713	12	catalyst	catalyst	NN
cord-300872-blycbi4u	713	13	-	-	HYPH
cord-300872-blycbi4u	713	14	free	free	JJ
cord-300872-blycbi4u	713	15	multicomponent	multicomponent	NN
cord-300872-blycbi4u	713	16	reactions	reaction	NNS
cord-300872-blycbi4u	713	17	in	in	IN
cord-300872-blycbi4u	713	18	water	water	NN
cord-300872-blycbi4u	714	1	This	this	DT
cord-300872-blycbi4u	714	2	article	article	NN
cord-300872-blycbi4u	714	3	is	be	VBZ
cord-300872-blycbi4u	714	4	an	an	DT
cord-300872-blycbi4u	714	5	open	open	JJ
cord-300872-blycbi4u	714	6	access	access	NN
cord-300872-blycbi4u	714	7	article	article	NN
cord-300872-blycbi4u	714	8	distributed	distribute	VBN
cord-300872-blycbi4u	714	9	under	under	IN
cord-300872-blycbi4u	714	10	the	the	DT
cord-300872-blycbi4u	714	11	terms	term	NNS
cord-300872-blycbi4u	714	12	and	and	CC
cord-300872-blycbi4u	714	13	conditions	condition	NNS
cord-300872-blycbi4u	714	14	of	of	IN
cord-300872-blycbi4u	714	15	the	the	DT
cord-300872-blycbi4u	714	16	Creative	Creative	NNP
cord-300872-blycbi4u	714	17	Commons	Commons	NNP
cord-300872-blycbi4u	714	18	Attribution	Attribution	NNP
cord-300872-blycbi4u	714	19	(	(	-LRB-
cord-300872-blycbi4u	714	20	CC	CC	NNP
cord-300872-blycbi4u	714	21	BY	by	IN
cord-300872-blycbi4u	714	22	)	)	-RRB-
cord-300872-blycbi4u	714	23	license	license	NN
cord-300872-blycbi4u	714	24	Funding	funding	NN
cord-300872-blycbi4u	714	25	:	:	:
cord-300872-blycbi4u	715	1	This	this	DT
cord-300872-blycbi4u	715	2	research	research	NN
cord-300872-blycbi4u	715	3	received	receive	VBD
cord-300872-blycbi4u	715	4	no	no	DT
cord-300872-blycbi4u	715	5	external	external	JJ
cord-300872-blycbi4u	715	6	funding	funding	NN
cord-300872-blycbi4u	715	7	.	.	.
cord-300872-blycbi4u	716	1	The	the	DT
cord-300872-blycbi4u	716	2	authors	author	NNS
cord-300872-blycbi4u	716	3	declare	declare	VBP
cord-300872-blycbi4u	716	4	no	no	DT
cord-300872-blycbi4u	716	5	conflict	conflict	NN
cord-300872-blycbi4u	716	6	of	of	IN
cord-300872-blycbi4u	716	7	interest	interest	NN
cord-300872-blycbi4u	716	8	.	.	.