id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017603-wq4cgqs2	Shanmugam, Naresh	Acute Liver Failure in Children	2018-10-16		.txt	text/plain	4424	248	40	Trying to address this issue, Bhaduri and Vergani defined ALF in children as "a rare multisystem disorder in which severe impairment of liver function, with or without encephalopathy, occurs in association with hepatocellular necrosis in a patient with no recognized underlying chronic liver disease" [2] . They used the following criteria to define acute liver failure (ALF) in children: (1) hepatic-based coagulopathy defined as a prothrombin time (PT) ≥ 15 s or international normalized ratio (INR) ≥ 1.5 not corrected by vitamin K in the presence of clinical hepatic encephalopathy (HE) or a PT ≥ 20 s or INR ≥ 2.0 regardless of the presence or absence of clinical hepatic encephalopathy (HE), (2) biochemical evidence of acute liver injury and (3) no known evidence of chronic liver disease [3] . A similar study in children failed to show any benefit, and Paediatric Acute Liver Failure study group does not recommend routine use of in non-acetaminophen-induced ALF in children [33] .	./cache/cord-017603-wq4cgqs2.txt	./txt/cord-017603-wq4cgqs2.txt