id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016057-efc6msf4	Blumberg, Lucille	Severe Malaria: Manifestations, diagnosis, chemotherapy, and management of severe malaria in adults	2005		.txt	text/plain	4788	267	46	In a confidential inquiry into malaria deaths in an area of South Africa with limited tertiary care facilities, major contributing factors were delays in diagnosis and initiation of adequate therapy, failure to administer the correct antimalarial at the correct dosage and frequency, inadequate monitoring of severity indicators in complicated cases, and the suboptimal management of complications (6). Some patients with severe malaria may have a negative smear due to sequestration of parasitised red blood cells, and a decision to treat with antimalarial chemotherapy should be considered if the index of suspicion is very high. The choice of chemotherapy for malaria is dependent on the severity of disease, the known or suspected resistance pattern of the parasite in the area where the malaria infection was acquired, the species of parasite, and patient profile (age, pregnancy, comorbidity, allergies, and medications, including any antimalarials recently administered). Acute renal failure in patients with severe falciparum malaria	./cache/cord-016057-efc6msf4.txt	./txt/cord-016057-efc6msf4.txt