id author title date pages extension mime words sentences flesch summary cache txt cord-005097-6xkx9a56 Herndler-Brandstetter, Dietmar Immunizations in the elderly: do they live up to their promise? 2006 .txt text/plain 6394 285 40 The present article aims at outlining the impact of infectious diseases on the elderly and summarizing the progress made in the field of vaccinations of the elderly and how age-related changes within the immune system contribute to the decreased efficacy of vaccines. The following paragraphs will now deal with the most important infectious diseases that threaten the elderly population and will present data on their occurrence, vaccine availability and efficacy, vaccination coverage and current health authority recommendations. This live-attenuated VZV vaccine, which is 14-times more potent than the currently available vaccines that prevent chickenpox, has specifically been developed to protect the reactivation of herpes zoster in elderly people [28, 29] . The frequent occurrence and severity of infectious diseases seen in the elderly is mostly related to an age-related decline in the functions of the immune system that also negatively influences the production of protective antibody levels after vaccination. ./cache/cord-005097-6xkx9a56.txt ./txt/cord-005097-6xkx9a56.txt