id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016903-z2vqfq98	Herndler-Brandstetter, Dietmar	The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly	2007		.txt	text/plain	6547	311	34	For instance, influenza, invasive Streptococcus pneumoniae infection, urinary tract and skin infections have a higher prevalence in elderly persons," Old individuals may also fail to respond sufficiently to therapy and frequently suffer from opportunistic infections, recurrent infections with the same pathogen or reactivation oflatent diseases, such as those caused by Mycobacterium tuberculosis or the Varicella zoster virus. This may lead to an increased morbidity and mortality and to a spreading ofthe disease, in particular within institutionalized elderly persons.P Further difficulties include the increased emergence of new, multiple drug-resistant strains with higher rransmissibiliry," the poor efficacy of the current bacille Calmette Guerin (BCG) vaccine in protecting adults and elderly people from pulmonary Infection" and the increased risk ofTB co-infection in HIV positive patients." However, in the past few years, several TB vaccine candidates have entered phase I clinical trials, including adjuvanted subunit vaccines as well as improved live recombinant strains of the current BCG vaccine (Table 1 ).	./cache/cord-016903-z2vqfq98.txt	./txt/cord-016903-z2vqfq98.txt