id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017916-wh708hes	Mocchegiani, Eugenio	Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Ageing and Longevity	2008-08-04		.txt	text/plain	12635	581	41	Some nutritional factors (zinc and selenium) may remodel these changes leading to a possible escaping of diseases with subsequent healthy ageing, because they are especially involved in improving immune functions as well as antioxidant defense. Therefore, the interrelationships between zinc and MT is crucial in maintaining the immune response especially in ageing where the production of proinflammatory cytokines is chronic leading to a constant presence of inflammatory status coupled with low intracellular zinc ion bioavailability (Mocchegiani et al. All these "in vitro" and "in vivo" studies in ageing, some age-related diseases, and syndrome of accelerated ageing (nude mice, nTx mice, Down's Syndrome) demonstrate the pivotal role played by zinc supplementation in maintaining or improving global immune response and in fighting the oxidative stress, strengthen by findings observed in human centenarians.	./cache/cord-017916-wh708hes.txt	./txt/cord-017916-wh708hes.txt