id author title date pages extension mime words sentences flesch summary cache txt cord-018387-ci5wx26t Di Benedetto, Svetlana Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition 2019-07-31 .txt text/plain 9553 431 31 Several lifestyle strategies, such as intervening to provide an adequate diet and physical and mental activity, have been shown to result in improved immune and neuroprotective functions, a decrease in oxidative stress and inflammation, and a potential increase in individual longevity. Thus, zinc deficiency may adversely affect the immunological status, increase oxidative stress, lead to the generation of inflammatory cytokines, and influence the progression of many chronic diseases, including atherosclerosis, neurological disorders, autoimmune diseases, age-related degenerative diseases, and various malignancies [5] . It has been suggested that aging is associated with chronic innate immune activation and significant changes in the functions of monocytes and macrophages, which may have implications for increased low-grade chronic inflammation and for the development of age-related diseases [61] . Evidence that long-term behavioral changes, including nutritional intervention and reduced energy intake together with physical activity, may prevent, improve, or even reverse age-related impairments in immune function continues to accumulate [2] . ./cache/cord-018387-ci5wx26t.txt ./txt/cord-018387-ci5wx26t.txt