id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282839-3ii79g6j	Moreno-Fernández Ayala, Daniel J.	Age-related mitochondrial dysfunction as a key factor in COVID-19 disease	2020-11-07		.txt	text/plain	10245	560	37	Thus, it seems clear that mitochondrial dysfunction is an important factor in the proinflammatory profile caused by the release of inflammatory cytokines produced by activation of NLRP3 inflammasome and other mechanisms over-activated in aging and in metabolic diseases. It seems clear that, mitochondrial dysfunction in diabetic patients contributes importantly to the low-grade inflammatory profile associated with this disease that is aggravated during aging and has been associated with higher severity in COVID-19 infection. Mediterranean diet, rich in plant foods, is associated with reduced risk of developing age-J o u r n a l P r e -p r o o f related chronic diseases by inducing protection against oxidative stress and improving mitochondrial activity that could be the cause of a reduced inflammation level (Tosti et al., 2018) . Mitochondrial dysfunction releases many damage signals to cytosol that end in the activation of inflammasome and the release of inflammatory cytokines that cause the chronic inflammation associated with aging and age-related diseases.	./cache/cord-282839-3ii79g6j.txt	./txt/cord-282839-3ii79g6j.txt