id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292024-ae7rauc6	Fulop, T.	Immunosenescence is both functional/adaptive and dysfunctional/maladaptive	2020-09-15		.txt	text/plain	10195	543	47	The increased numbers and activity of certain innate or innate-like immune cell subsets with aging might be considered host responses to compensate for the drastic decline in adaptive immune cell development and function [95] . Several studies have also indicated age-related functional changes in DCs, such as impaired expression of TLRs [115] ; decreased production of cytokines, chemokines, and IFN-a after TLR stimulation [112] [113] [114] [115] [116] ; and increased responses to self-antigen [117] . In the meantime, senescent T cells, analogously to other senescent cells arising with age in the body, produce large amounts of proinflammatory cytokines (a phenomenon called senescence-associated secretory phenotype, SASP) as stated by the inflammaging characteristics of the human immune system [141, 142] . Given the central role of Treg cells in immune homeostasis, age-related loss of Treg function would be predicted to render the host susceptible to excessive immunity, encountered in elderly humans as a syndrome of chronic low-grade inflammation [172] .	./cache/cord-292024-ae7rauc6.txt	./txt/cord-292024-ae7rauc6.txt