id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294501-1nf98mpb	Bonafè, Massimiliano	Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes	2020-05-03		.txt	text/plain	3745	197	40	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by a high mortality of elderly men with age-related comorbidities. Consistent with this finding, the ability of DCs and macrophages to elicit CD8 + T cell response and proliferation and to release antiviral cytokines is impaired in elderly individuals [34] ; in parallel, these subjects are characterized by a reduced activity of plasmacytoid DCs, the main sources of type I IFNs, which underpin the antiviral response and provide the first-line sentinels in immune surveillance, also in the lung [35] . 4. In older men with age-related diseases, the aging-dependent reduction in ACE2 activity worsens SARS-CoV-2 infection outcomes Angiotensin-converting enzyme (ACE)2, the main SARS-CoV2 host cell receptor, plays a crucial role in virus entry into the cell, as previously demonstrated in SARS and NL63 human coronaviruses [41] . In these individuals, acute SARS-CoV-2 infection compounds their chronic, subclinical, aging-related proinflammatory state (inflamm-aging) which, together with immune senescence and the age-and gender-specific distribution of ACE2 in the airway epithelia, could blunt the antiviral response to inflammation.	./cache/cord-294501-1nf98mpb.txt	./txt/cord-294501-1nf98mpb.txt