id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315992-jxxio17w	Borja-Gonzalez, Maria	Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function	2020-07-08		.txt	text/plain	3030	194	42	The role of microRNAs (miRNAs, miRs) as epigenetic modifiers in regulating loss of muscle mass and function has become increasingly recognised (reviewed in [17] ). It therefore appears that miR-181 may play a critical role in regulating redox homeostasis and potentially mitochondrial dynamics in nervous and cardiac cells, with studies suggesting that inhibition of miR-181 may prevent cell death and improve antioxidant response via targeting BCL-1, BCL-2, GRP78 and PTEN. In our study, using miR gain-and loss-of-function approaches, we have demonstrated that miR-181 regulates skeletal muscle size and function during aging through regulating mitochondrial dynamics [46] . This may also suggest the important role of miR-181 family in a multitude of disorders associated with changes in mitochondrial dynamics and oxidative stress, such as sarcopenia or aging. The potential of miRs as novel therapeutics for various disorders has been proposed due to their implication in regulating multiple pathways and involvement in many disease states including aging and sarcopenia [25] , [27] , [35] .	./cache/cord-315992-jxxio17w.txt	./txt/cord-315992-jxxio17w.txt