id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353600-5wo74ms4	Tyrrell, Daniel J.	Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6	2020-09-11		.txt	text/plain	8240	392	31	In mice, ageing is associated with an elevation in the levels of the inflammatory cytokine IL-6 in the aorta, which participates in a positive feedback loop with the impaired vascular mitochondrial function to accelerate atherogenesis. • Ageing-related alterations in the bone marrow increase the phenomenon of clonal haematopoiesis of indeterminate potential (CHIP) and promote a skewing towards myeloid cell differentiation, both of which can accelerate atherosclerosis. • The role of the vasculature and myeloid cells of the immune system in promoting age-related atherosclerosis might be mediated by shared inflammatory pathways, in particular IL-6 signalling. In a 2019 study in mice, β 2 adrenergic receptor signalling in the bone marrow niche was found to increase with ageing in association with increased generation of myeloid cells and platelets through an IL6 dependent mechanism 60 . Blocking IL-6 might interfere with the increased IL-6 signalling in bone marrow adipocytes that occurs with ageing (which promotes a skewing towards myeloid cell differentiation), thereby reducing the risk of clonal haematopoiesis of indeterminate potential (CHIP).	./cache/cord-353600-5wo74ms4.txt	./txt/cord-353600-5wo74ms4.txt