id	sid	tid	token	lemma	pos
cord-007084-4niom5mw	1	1	key	key	JJ
cord-007084-4niom5mw	1	2	:	:	:
cord-007084-4niom5mw	1	3	cord-007084	cord-007084	NN
cord-007084-4niom5mw	1	4	-	-	HYPH
cord-007084-4niom5mw	1	5	4niom5mw	4niom5mw	CD
cord-007084-4niom5mw	1	6	authors	author	NNS
cord-007084-4niom5mw	1	7	:	:	:
cord-007084-4niom5mw	1	8	POPPLEWELL	POPPLEWELL	NNP
cord-007084-4niom5mw	1	9	,	,	,
cord-007084-4niom5mw	1	10	PHILIP	PHILIP	NNP
cord-007084-4niom5mw	1	11	Y.	Y.	NNP
cord-007084-4niom5mw	1	12	;	;	:
cord-007084-4niom5mw	1	13	BUTTE	BUTTE	NNP
cord-007084-4niom5mw	1	14	,	,	,
cord-007084-4niom5mw	1	15	JOHN	JOHN	NNP
cord-007084-4niom5mw	1	16	;	;	:
cord-007084-4niom5mw	1	17	AZHAR	AZHAR	NNP
cord-007084-4niom5mw	1	18	,	,	,
cord-007084-4niom5mw	2	1	SALMAN	SALMAN	NNP
cord-007084-4niom5mw	2	2	title	title	NN
cord-007084-4niom5mw	2	3	:	:	:
cord-007084-4niom5mw	3	1	The	the	DT
cord-007084-4niom5mw	3	2	Influence	Influence	NNP
cord-007084-4niom5mw	3	3	of	of	IN
cord-007084-4niom5mw	3	4	Age	Age	NNP
cord-007084-4niom5mw	3	5	on	on	IN
cord-007084-4niom5mw	3	6	Steroidogenic	Steroidogenic	NNP
cord-007084-4niom5mw	3	7	Enzyme	Enzyme	NNP
cord-007084-4niom5mw	3	8	Activities	Activities	NNPS
cord-007084-4niom5mw	3	9	of	of	IN
cord-007084-4niom5mw	3	10	the	the	DT
cord-007084-4niom5mw	3	11	Rat	Rat	NNP
cord-007084-4niom5mw	3	12	Adrenal	Adrenal	NNP
cord-007084-4niom5mw	3	13	Gland	Gland	NNP
cord-007084-4niom5mw	3	14	:	:	:
cord-007084-4niom5mw	3	15	Enhanced	enhanced	JJ
cord-007084-4niom5mw	3	16	Expression	expression	NN
cord-007084-4niom5mw	3	17	of	of	IN
cord-007084-4niom5mw	3	18	Cholesterol	Cholesterol	NNP
cord-007084-4niom5mw	3	19	Side	Side	NNP
cord-007084-4niom5mw	3	20	-	-	HYPH
cord-007084-4niom5mw	3	21	Chain	Chain	NNP
cord-007084-4niom5mw	3	22	Cleavage	cleavage	NN
cord-007084-4niom5mw	3	23	Activity	activity	NN
cord-007084-4niom5mw	4	1	(	(	-LRB-
cord-007084-4niom5mw	4	2	*	*	NFP
cord-007084-4niom5mw	4	3	)	)	-RRB-
cord-007084-4niom5mw	4	4	date	date	NN
cord-007084-4niom5mw	4	5	:	:	:
cord-007084-4niom5mw	4	6	1987	1987	CD
cord-007084-4niom5mw	4	7	-	-	SYM
cord-007084-4niom5mw	4	8	06	06	CD
cord-007084-4niom5mw	4	9	-	-	HYPH
cord-007084-4niom5mw	4	10	01	01	CD
cord-007084-4niom5mw	4	11	journal	journal	NN
cord-007084-4niom5mw	4	12	:	:	:
cord-007084-4niom5mw	4	13	Endocrinology	Endocrinology	NNP
cord-007084-4niom5mw	4	14	DOI	DOI	NNP
cord-007084-4niom5mw	4	15	:	:	:
cord-007084-4niom5mw	4	16	10.1210	10.1210	CD
cord-007084-4niom5mw	4	17	/	/	SYM
cord-007084-4niom5mw	4	18	endo-120	endo-120	CD
cord-007084-4niom5mw	4	19	-	-	HYPH
cord-007084-4niom5mw	4	20	6	6	CD
cord-007084-4niom5mw	4	21	-	-	HYPH
cord-007084-4niom5mw	4	22	2521	2521	CD
cord-007084-4niom5mw	4	23	sha	sha	NNP
cord-007084-4niom5mw	4	24	:	:	:
cord-007084-4niom5mw	4	25	f4cb5c1bc8d5199a3bbee98951395f015eccdef9	f4cb5c1bc8d5199a3bbee98951395f015eccdef9	NFP
cord-007084-4niom5mw	4	26	doc_id	doc_id	CD
cord-007084-4niom5mw	4	27	:	:	:
cord-007084-4niom5mw	5	1	7084	7084	CD
cord-007084-4niom5mw	5	2	cord_uid	cord_uid	NN
cord-007084-4niom5mw	5	3	:	:	:
cord-007084-4niom5mw	6	1	4niom5mw	4niom5mw	CD
cord-007084-4niom5mw	7	1	The	the	DT
cord-007084-4niom5mw	7	2	ability	ability	NN
cord-007084-4niom5mw	7	3	of	of	IN
cord-007084-4niom5mw	7	4	isolated	isolate	VBN
cord-007084-4niom5mw	7	5	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	7	6	cells	cell	NNS
cord-007084-4niom5mw	7	7	to	to	TO
cord-007084-4niom5mw	7	8	secrete	secrete	VB
cord-007084-4niom5mw	7	9	corticosterone	corticosterone	NN
cord-007084-4niom5mw	7	10	in	in	IN
cord-007084-4niom5mw	7	11	response	response	NN
cord-007084-4niom5mw	7	12	to	to	IN
cord-007084-4niom5mw	7	13	ACTH	ACTH	NNP
cord-007084-4niom5mw	7	14	challenge	challenge	NN
cord-007084-4niom5mw	7	15	declines	decline	VBZ
cord-007084-4niom5mw	7	16	as	as	IN
cord-007084-4niom5mw	7	17	rats	rat	NNS
cord-007084-4niom5mw	7	18	age	age	NN
cord-007084-4niom5mw	7	19	,	,	,
cord-007084-4niom5mw	7	20	but	but	CC
cord-007084-4niom5mw	7	21	the	the	DT
cord-007084-4niom5mw	7	22	site	site	NN
cord-007084-4niom5mw	7	23	or	or	CC
cord-007084-4niom5mw	7	24	mechanism(s	mechanism(s	NNP
cord-007084-4niom5mw	7	25	)	)	-RRB-
cord-007084-4niom5mw	7	26	of	of	IN
cord-007084-4niom5mw	7	27	this	this	DT
cord-007084-4niom5mw	7	28	impairment	impairment	NN
cord-007084-4niom5mw	7	29	is	be	VBZ
cord-007084-4niom5mw	7	30	still	still	RB
cord-007084-4niom5mw	7	31	unknown	unknown	JJ
cord-007084-4niom5mw	7	32	.	.	.
cord-007084-4niom5mw	8	1	To	to	TO
cord-007084-4niom5mw	8	2	test	test	VB
cord-007084-4niom5mw	8	3	the	the	DT
cord-007084-4niom5mw	8	4	functionality	functionality	NN
cord-007084-4niom5mw	8	5	of	of	IN
cord-007084-4niom5mw	8	6	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	8	7	capacity	capacity	NN
cord-007084-4niom5mw	8	8	per	per	FW
cord-007084-4niom5mw	8	9	se	se	FW
cord-007084-4niom5mw	8	10	,	,	,
cord-007084-4niom5mw	8	11	we	-PRON-	PRP
cord-007084-4niom5mw	8	12	measured	measure	VBD
cord-007084-4niom5mw	8	13	the	the	DT
cord-007084-4niom5mw	8	14	key	key	JJ
cord-007084-4niom5mw	8	15	enzyme	enzyme	NN
cord-007084-4niom5mw	8	16	activities	activity	NNS
cord-007084-4niom5mw	8	17	involved	involve	VBN
cord-007084-4niom5mw	8	18	in	in	IN
cord-007084-4niom5mw	8	19	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	8	20	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	8	21	.	.	.
cord-007084-4niom5mw	9	1	We	-PRON-	PRP
cord-007084-4niom5mw	9	2	also	also	RB
cord-007084-4niom5mw	9	3	measured	measure	VBD
cord-007084-4niom5mw	9	4	the	the	DT
cord-007084-4niom5mw	9	5	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	9	6	cytochrome	cytochrome	NN
cord-007084-4niom5mw	9	7	P-450	P-450	VBD
cord-007084-4niom5mw	9	8	content	content	NN
cord-007084-4niom5mw	9	9	and	and	CC
cord-007084-4niom5mw	9	10	nonsteroidogenic	nonsteroidogenic	NNP
cord-007084-4niom5mw	9	11	enzymes	enzyme	NNS
cord-007084-4niom5mw	9	12	specific	specific	JJ
cord-007084-4niom5mw	9	13	for	for	IN
cord-007084-4niom5mw	9	14	subcellular	subcellular	JJ
cord-007084-4niom5mw	9	15	fractions	fraction	NNS
cord-007084-4niom5mw	9	16	.	.	.
cord-007084-4niom5mw	10	1	Mitochondria	mitochondria	NN
cord-007084-4niom5mw	10	2	and	and	CC
cord-007084-4niom5mw	10	3	microsomal	microsomal	NN
cord-007084-4niom5mw	10	4	fractions	fraction	NNS
cord-007084-4niom5mw	10	5	were	be	VBD
cord-007084-4niom5mw	10	6	isolated	isolate	VBN
cord-007084-4niom5mw	10	7	from	from	IN
cord-007084-4niom5mw	10	8	the	the	DT
cord-007084-4niom5mw	10	9	adrenals	adrenal	NNS
cord-007084-4niom5mw	10	10	of	of	IN
cord-007084-4niom5mw	10	11	2-	2-	CD
cord-007084-4niom5mw	10	12	,	,	,
cord-007084-4niom5mw	10	13	12-	12-	NNP
cord-007084-4niom5mw	10	14	,	,	,
cord-007084-4niom5mw	10	15	and	and	CC
cord-007084-4niom5mw	10	16	18-	18-	CD
cord-007084-4niom5mw	10	17	month	month	NN
cord-007084-4niom5mw	10	18	-	-	HYPH
cord-007084-4niom5mw	10	19	old	old	JJ
cord-007084-4niom5mw	10	20	animals	animal	NNS
cord-007084-4niom5mw	10	21	and	and	CC
cord-007084-4niom5mw	10	22	used	use	VBN
cord-007084-4niom5mw	10	23	for	for	IN
cord-007084-4niom5mw	10	24	various	various	JJ
cord-007084-4niom5mw	10	25	enzyme	enzyme	NN
cord-007084-4niom5mw	10	26	measurements	measurement	NNS
cord-007084-4niom5mw	10	27	.	.	.
cord-007084-4niom5mw	11	1	Mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	11	2	side	side	NN
cord-007084-4niom5mw	11	3	-	-	HYPH
cord-007084-4niom5mw	11	4	chain	chain	NN
cord-007084-4niom5mw	11	5	cleavage	cleavage	NN
cord-007084-4niom5mw	11	6	enzyme	enzyme	NN
cord-007084-4niom5mw	11	7	activity	activity	NN
cord-007084-4niom5mw	11	8	(	(	-LRB-
cord-007084-4niom5mw	11	9	nanomoles	nanomole	NNS
cord-007084-4niom5mw	11	10	per	per	IN
cord-007084-4niom5mw	11	11	min	min	NNP
cord-007084-4niom5mw	11	12	mg	mg	NNP
cord-007084-4niom5mw	11	13	protein(-1	protein(-1	NNP
cord-007084-4niom5mw	11	14	)	)	-RRB-
cord-007084-4niom5mw	11	15	)	)	-RRB-
cord-007084-4niom5mw	11	16	increased	increase	VBD
cord-007084-4niom5mw	11	17	from	from	IN
cord-007084-4niom5mw	11	18	a	a	DT
cord-007084-4niom5mw	11	19	mean	mean	NN
cord-007084-4niom5mw	11	20	of	of	IN
cord-007084-4niom5mw	11	21	0.43	0.43	CD
cord-007084-4niom5mw	11	22	±	±	CD
cord-007084-4niom5mw	11	23	0.06	0.06	CD
cord-007084-4niom5mw	11	24	in	in	IN
cord-007084-4niom5mw	11	25	2-month	2-month	JJ
cord-007084-4niom5mw	11	26	-	-	HYPH
cord-007084-4niom5mw	11	27	old	old	JJ
cord-007084-4niom5mw	11	28	rats	rat	NNS
cord-007084-4niom5mw	11	29	to	to	IN
cord-007084-4niom5mw	11	30	1.26	1.26	CD
cord-007084-4niom5mw	11	31	±	±	CD
cord-007084-4niom5mw	11	32	0.11	0.11	CD
cord-007084-4niom5mw	11	33	and	and	CC
cord-007084-4niom5mw	11	34	1.51	1.51	CD
cord-007084-4niom5mw	11	35	±	±	CD
cord-007084-4niom5mw	11	36	0.06	0.06	CD
cord-007084-4niom5mw	11	37	in	in	IN
cord-007084-4niom5mw	11	38	12-	12-	NNP
cord-007084-4niom5mw	11	39	and	and	CC
cord-007084-4niom5mw	11	40	18-month	18-month	JJ
cord-007084-4niom5mw	11	41	old	old	JJ
cord-007084-4niom5mw	11	42	rats	rat	NNS
cord-007084-4niom5mw	11	43	,	,	,
cord-007084-4niom5mw	11	44	respectively	respectively	RB
cord-007084-4niom5mw	11	45	.	.	.
cord-007084-4niom5mw	12	1	After	after	IN
cord-007084-4niom5mw	12	2	incubation	incubation	NN
cord-007084-4niom5mw	12	3	with	with	IN
cord-007084-4niom5mw	12	4	5-	5-	NNP
cord-007084-4niom5mw	12	5	cholesten-3j8,25-diol	cholesten-3j8,25-diol	NNP
cord-007084-4niom5mw	12	6	(	(	-LRB-
cord-007084-4niom5mw	12	7	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	12	8	;	;	:
cord-007084-4niom5mw	12	9	25	25	CD
cord-007084-4niom5mw	12	10	μg	μg	NNP
cord-007084-4niom5mw	12	11	/	/	SYM
cord-007084-4niom5mw	12	12	ml	ml	NN
cord-007084-4niom5mw	12	13	)	)	-RRB-
cord-007084-4niom5mw	12	14	sidechain	sidechain	NN
cord-007084-4niom5mw	12	15	cleave	cleave	NN
cord-007084-4niom5mw	12	16	activity	activity	NN
cord-007084-4niom5mw	12	17	rose	rise	VBD
cord-007084-4niom5mw	12	18	to	to	IN
cord-007084-4niom5mw	12	19	5.0	5.0	CD
cord-007084-4niom5mw	12	20	±	±	CD
cord-007084-4niom5mw	12	21	0.6	0.6	CD
cord-007084-4niom5mw	12	22	,	,	,
cord-007084-4niom5mw	12	23	12.4	12.4	CD
cord-007084-4niom5mw	12	24	±	±	CD
cord-007084-4niom5mw	12	25	1.2	1.2	CD
cord-007084-4niom5mw	12	26	,	,	,
cord-007084-4niom5mw	12	27	and	and	CC
cord-007084-4niom5mw	12	28	16	16	CD
cord-007084-4niom5mw	12	29	±	±	CD
cord-007084-4niom5mw	12	30	1.4	1.4	CD
cord-007084-4niom5mw	12	31	nmol	nmol	JJ
cord-007084-4niom5mw	12	32	min(-1	min(-1	NN
cord-007084-4niom5mw	12	33	)	)	-RRB-
cord-007084-4niom5mw	13	1	mg	mg	NNP
cord-007084-4niom5mw	13	2	protein(-1	protein(-1	NNP
cord-007084-4niom5mw	13	3	)	)	-RRB-
cord-007084-4niom5mw	14	1	in	in	IN
cord-007084-4niom5mw	14	2	adrenal	adrenal	JJ
cord-007084-4niom5mw	14	3	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	14	4	fractions	fraction	NNS
cord-007084-4niom5mw	14	5	from	from	IN
cord-007084-4niom5mw	14	6	2-	2-	CD
cord-007084-4niom5mw	14	7	,	,	,
cord-007084-4niom5mw	14	8	12-	12-	NNP
cord-007084-4niom5mw	14	9	,	,	,
cord-007084-4niom5mw	14	10	and	and	CC
cord-007084-4niom5mw	14	11	18-month	18-month	JJ
cord-007084-4niom5mw	14	12	-	-	HYPH
cord-007084-4niom5mw	14	13	old	old	JJ
cord-007084-4niom5mw	14	14	rats	rat	NNS
cord-007084-4niom5mw	14	15	,	,	,
cord-007084-4niom5mw	14	16	respectively	respectively	RB
cord-007084-4niom5mw	14	17	.	.	.
cord-007084-4niom5mw	15	1	In	in	IN
cord-007084-4niom5mw	15	2	contrast	contrast	NN
cord-007084-4niom5mw	15	3	,	,	,
cord-007084-4niom5mw	15	4	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	15	5	cytochrome	cytochrome	NN
cord-007084-4niom5mw	15	6	P-450	p-450	NN
cord-007084-4niom5mw	15	7	content	content	NN
cord-007084-4niom5mw	15	8	did	do	VBD
cord-007084-4niom5mw	15	9	not	not	RB
cord-007084-4niom5mw	15	10	vary	vary	VB
cord-007084-4niom5mw	15	11	with	with	IN
cord-007084-4niom5mw	15	12	advancing	advance	VBG
cord-007084-4niom5mw	15	13	age	age	NN
cord-007084-4niom5mw	15	14	.	.	.
cord-007084-4niom5mw	16	1	Microsomal	Microsomal	NNP
cord-007084-4niom5mw	16	2	δ(5)-3β	δ(5)-3β	NNP
cord-007084-4niom5mw	16	3	-	-	HYPH
cord-007084-4niom5mw	16	4	hyroxysteroid	hyroxysteroid	NNP
cord-007084-4niom5mw	17	1	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	17	2	-	-	HYPH
cord-007084-4niom5mw	17	3	δ(5)-δ(4)-	δ(5)-δ(4)-	JJ
cord-007084-4niom5mw	17	4	isomerase	isomerase	NN
cord-007084-4niom5mw	17	5	activities	activity	NNS
cord-007084-4niom5mw	17	6	were	be	VBD
cord-007084-4niom5mw	17	7	similar	similar	JJ
cord-007084-4niom5mw	17	8	in	in	IN
cord-007084-4niom5mw	17	9	2-	2-	NN
cord-007084-4niom5mw	17	10	and	and	CC
cord-007084-4niom5mw	17	11	12-month	12-month	JJ
cord-007084-4niom5mw	17	12	-	-	HYPH
cord-007084-4niom5mw	17	13	old	old	JJ
cord-007084-4niom5mw	17	14	rats	rat	NNS
cord-007084-4niom5mw	17	15	,	,	,
cord-007084-4niom5mw	17	16	but	but	CC
cord-007084-4niom5mw	17	17	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	17	18	(	(	-LRB-
cord-007084-4niom5mw	17	19	nanomoles	nanomole	NNS
cord-007084-4niom5mw	17	20	per	per	IN
cord-007084-4niom5mw	17	21	min	min	NNP
cord-007084-4niom5mw	17	22	mg	mg	NNP
cord-007084-4niom5mw	17	23	protein(-1	protein(-1	NNP
cord-007084-4niom5mw	17	24	)	)	-RRB-
cord-007084-4niom5mw	17	25	)	)	-RRB-
cord-007084-4niom5mw	18	1	activity	activity	NN
cord-007084-4niom5mw	18	2	was	be	VBD
cord-007084-4niom5mw	18	3	significantly	significantly	RB
cord-007084-4niom5mw	18	4	increased	increase	VBN
cord-007084-4niom5mw	18	5	in	in	IN
cord-007084-4niom5mw	18	6	12-month	12-month	JJ
cord-007084-4niom5mw	18	7	-	-	HYPH
cord-007084-4niom5mw	18	8	old	old	JJ
cord-007084-4niom5mw	18	9	rats	rat	NNS
cord-007084-4niom5mw	18	10	(	(	-LRB-
cord-007084-4niom5mw	18	11	2-month	2-month	JJ
cord-007084-4niom5mw	18	12	-	-	HYPH
cord-007084-4niom5mw	18	13	old	old	JJ
cord-007084-4niom5mw	18	14	,	,	,
cord-007084-4niom5mw	18	15	5.2	5.2	CD
cord-007084-4niom5mw	18	16	±	±	CD
cord-007084-4niom5mw	18	17	0.2	0.2	CD
cord-007084-4niom5mw	18	18	;	;	:
cord-007084-4niom5mw	18	19	12-month	12-month	JJ
cord-007084-4niom5mw	18	20	-	-	HYPH
cord-007084-4niom5mw	18	21	old	old	JJ
cord-007084-4niom5mw	18	22	,	,	,
cord-007084-4niom5mw	18	23	7.7	7.7	CD
cord-007084-4niom5mw	18	24	±	±	CD
cord-007084-4niom5mw	18	25	0.5	0.5	CD
cord-007084-4niom5mw	18	26	)	)	-RRB-
cord-007084-4niom5mw	18	27	.	.	.
cord-007084-4niom5mw	19	1	Finally	finally	RB
cord-007084-4niom5mw	19	2	,	,	,
cord-007084-4niom5mw	19	3	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	19	4	11β-	11β-	CD
cord-007084-4niom5mw	19	5	hydroxylase	hydroxylase	NN
cord-007084-4niom5mw	19	6	was	be	VBD
cord-007084-4niom5mw	19	7	comparable	comparable	JJ
cord-007084-4niom5mw	19	8	in	in	IN
cord-007084-4niom5mw	19	9	both	both	DT
cord-007084-4niom5mw	19	10	age	age	NN
cord-007084-4niom5mw	19	11	groups	group	NNS
cord-007084-4niom5mw	19	12	.	.	.
cord-007084-4niom5mw	20	1	In	in	IN
cord-007084-4niom5mw	20	2	addition	addition	NN
cord-007084-4niom5mw	20	3	,	,	,
cord-007084-4niom5mw	20	4	activities	activity	NNS
cord-007084-4niom5mw	20	5	of	of	IN
cord-007084-4niom5mw	20	6	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	20	7	nonsteroidogenic	nonsteroidogenic	NNP
cord-007084-4niom5mw	20	8	enzymes	enzyme	NNS
cord-007084-4niom5mw	20	9	,	,	,
cord-007084-4niom5mw	20	10	such	such	JJ
cord-007084-4niom5mw	20	11	as	as	IN
cord-007084-4niom5mw	20	12	monoamine	monoamine	NN
cord-007084-4niom5mw	20	13	oxidase	oxidase	NN
cord-007084-4niom5mw	20	14	,	,	,
cord-007084-4niom5mw	20	15	amytal	amytal	JJ
cord-007084-4niom5mw	20	16	insensitive	insensitive	JJ
cord-007084-4niom5mw	20	17	NADH	NADH	NNP
cord-007084-4niom5mw	20	18	cytochrome	cytochrome	NN
cord-007084-4niom5mw	20	19	c	c	NN
cord-007084-4niom5mw	20	20	reductase	reductase	NN
cord-007084-4niom5mw	20	21	,	,	,
cord-007084-4niom5mw	20	22	cytochrome	cytochrome	NN
cord-007084-4niom5mw	20	23	c	c	NN
cord-007084-4niom5mw	20	24	oxidase	oxidase	NN
cord-007084-4niom5mw	20	25	,	,	,
cord-007084-4niom5mw	20	26	succinate	succinate	NN
cord-007084-4niom5mw	20	27	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	20	28	,	,	,
cord-007084-4niom5mw	20	29	and	and	CC
cord-007084-4niom5mw	20	30	malate	malate	NNP
cord-007084-4niom5mw	20	31	dehydrogenase	dehydrogenase	NNP
cord-007084-4niom5mw	20	32	,	,	,
cord-007084-4niom5mw	20	33	did	do	VBD
cord-007084-4niom5mw	20	34	not	not	RB
cord-007084-4niom5mw	20	35	change	change	VB
cord-007084-4niom5mw	20	36	with	with	IN
cord-007084-4niom5mw	20	37	age	age	NN
cord-007084-4niom5mw	20	38	.	.	.
cord-007084-4niom5mw	21	1	It	-PRON-	PRP
cord-007084-4niom5mw	21	2	appears	appear	VBZ
cord-007084-4niom5mw	21	3	from	from	IN
cord-007084-4niom5mw	21	4	the	the	DT
cord-007084-4niom5mw	21	5	evidence	evidence	NN
cord-007084-4niom5mw	21	6	presented	present	VBD
cord-007084-4niom5mw	21	7	that	that	IN
cord-007084-4niom5mw	21	8	the	the	DT
cord-007084-4niom5mw	21	9	activities	activity	NNS
cord-007084-4niom5mw	21	10	of	of	IN
cord-007084-4niom5mw	21	11	the	the	DT
cord-007084-4niom5mw	21	12	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	21	13	enzymes	enzyme	NNS
cord-007084-4niom5mw	21	14	are	be	VBP
cord-007084-4niom5mw	21	15	not	not	RB
cord-007084-4niom5mw	21	16	responsible	responsible	JJ
cord-007084-4niom5mw	21	17	for	for	IN
cord-007084-4niom5mw	21	18	the	the	DT
cord-007084-4niom5mw	21	19	diminished	diminished	JJ
cord-007084-4niom5mw	21	20	capacity	capacity	NN
cord-007084-4niom5mw	21	21	in	in	IN
cord-007084-4niom5mw	21	22	corticosterone	corticosterone	NN
cord-007084-4niom5mw	21	23	production	production	NN
cord-007084-4niom5mw	21	24	seen	see	VBN
cord-007084-4niom5mw	21	25	with	with	IN
cord-007084-4niom5mw	21	26	aging	age	VBG
cord-007084-4niom5mw	21	27	in	in	IN
cord-007084-4niom5mw	21	28	the	the	DT
cord-007084-4niom5mw	21	29	rat	rat	NN
cord-007084-4niom5mw	21	30	.	.	.
cord-007084-4niom5mw	22	1	(	(	-LRB-
cord-007084-4niom5mw	22	2	Endocrinology120	Endocrinology120	NNP
cord-007084-4niom5mw	22	3	:	:	:
cord-007084-4niom5mw	23	1	2521–2528,1987	2521–2528,1987	LS
cord-007084-4niom5mw	23	2	)	)	-RRB-
cord-007084-4niom5mw	24	1	I	-PRON-	PRP
cord-007084-4niom5mw	24	2	T	T	NNP
cord-007084-4niom5mw	24	3	HAS	have	VBZ
cord-007084-4niom5mw	24	4	been	be	VBN
cord-007084-4niom5mw	24	5	reported	report	VBN
cord-007084-4niom5mw	24	6	previously	previously	RB
cord-007084-4niom5mw	24	7	from	from	IN
cord-007084-4niom5mw	24	8	this	this	DT
cord-007084-4niom5mw	24	9	laboratory	laboratory	NN
cord-007084-4niom5mw	24	10	that	that	WDT
cord-007084-4niom5mw	24	11	the	the	DT
cord-007084-4niom5mw	24	12	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	24	13	capacity	capacity	NN
cord-007084-4niom5mw	24	14	of	of	IN
cord-007084-4niom5mw	24	15	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	24	16	cells	cell	NNS
cord-007084-4niom5mw	24	17	declines	decline	VBZ
cord-007084-4niom5mw	24	18	as	as	IN
cord-007084-4niom5mw	24	19	rats	rat	NNS
cord-007084-4niom5mw	24	20	age	age	NN
cord-007084-4niom5mw	24	21	(	(	-LRB-
cord-007084-4niom5mw	24	22	1	1	CD
cord-007084-4niom5mw	24	23	)	)	-RRB-
cord-007084-4niom5mw	24	24	.	.	.
cord-007084-4niom5mw	25	1	Furthermore	furthermore	RB
cord-007084-4niom5mw	25	2	,	,	,
cord-007084-4niom5mw	25	3	this	this	DT
cord-007084-4niom5mw	25	4	defect	defect	NN
cord-007084-4niom5mw	25	5	seems	seem	VBZ
cord-007084-4niom5mw	25	6	to	to	TO
cord-007084-4niom5mw	25	7	be	be	VB
cord-007084-4niom5mw	25	8	due	due	JJ
cord-007084-4niom5mw	25	9	to	to	IN
cord-007084-4niom5mw	25	10	biochemical	biochemical	JJ
cord-007084-4niom5mw	25	11	events	event	NNS
cord-007084-4niom5mw	25	12	distal	distal	JJ
cord-007084-4niom5mw	25	13	to	to	IN
cord-007084-4niom5mw	25	14	binding	bind	VBG
cord-007084-4niom5mw	25	15	of	of	IN
cord-007084-4niom5mw	25	16	ACTH	ACTH	NNP
cord-007084-4niom5mw	25	17	to	to	IN
cord-007084-4niom5mw	25	18	its	-PRON-	PRP$
cord-007084-4niom5mw	25	19	receptor	receptor	NN
cord-007084-4niom5mw	25	20	and	and	CC
cord-007084-4niom5mw	25	21	stimulation	stimulation	NN
cord-007084-4niom5mw	25	22	of	of	IN
cord-007084-4niom5mw	25	23	cAMP	camp	NN
cord-007084-4niom5mw	25	24	production	production	NN
cord-007084-4niom5mw	25	25	(	(	-LRB-
cord-007084-4niom5mw	25	26	1	1	CD
cord-007084-4niom5mw	25	27	)	)	-RRB-
cord-007084-4niom5mw	25	28	.	.	.
cord-007084-4niom5mw	26	1	Although	although	IN
cord-007084-4niom5mw	26	2	the	the	DT
cord-007084-4niom5mw	26	3	exact	exact	JJ
cord-007084-4niom5mw	26	4	mechanism	mechanism	NN
cord-007084-4niom5mw	26	5	of	of	IN
cord-007084-4niom5mw	26	6	this	this	DT
cord-007084-4niom5mw	26	7	defect	defect	NN
cord-007084-4niom5mw	26	8	is	be	VBZ
cord-007084-4niom5mw	26	9	yet	yet	RB
cord-007084-4niom5mw	26	10	to	to	TO
cord-007084-4niom5mw	26	11	be	be	VB
cord-007084-4niom5mw	26	12	defined	define	VBN
cord-007084-4niom5mw	26	13	,	,	,
cord-007084-4niom5mw	26	14	the	the	DT
cord-007084-4niom5mw	26	15	possibility	possibility	NN
cord-007084-4niom5mw	26	16	that	that	IN
cord-007084-4niom5mw	26	17	this	this	DT
cord-007084-4niom5mw	26	18	phenomenon	phenomenon	NN
cord-007084-4niom5mw	26	19	may	may	MD
cord-007084-4niom5mw	26	20	represent	represent	VB
cord-007084-4niom5mw	26	21	a	a	DT
cord-007084-4niom5mw	26	22	direct	direct	JJ
cord-007084-4niom5mw	26	23	effect	effect	NN
cord-007084-4niom5mw	26	24	on	on	IN
cord-007084-4niom5mw	26	25	the	the	DT
cord-007084-4niom5mw	26	26	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	26	27	process	process	NN
cord-007084-4niom5mw	26	28	per	per	FW
cord-007084-4niom5mw	26	29	se	se	FW
cord-007084-4niom5mw	26	30	is	be	VBZ
cord-007084-4niom5mw	26	31	quite	quite	RB
cord-007084-4niom5mw	26	32	appealing	appealing	JJ
cord-007084-4niom5mw	26	33	.	.	.
cord-007084-4niom5mw	27	1	In	in	IN
cord-007084-4niom5mw	27	2	rat	rat	NN
cord-007084-4niom5mw	27	3	adrenals	adrenal	NNS
cord-007084-4niom5mw	27	4	,	,	,
cord-007084-4niom5mw	27	5	steroid	steroid	NN
cord-007084-4niom5mw	27	6	(	(	-LRB-
cord-007084-4niom5mw	27	7	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	27	8	)	)	-RRB-
cord-007084-4niom5mw	27	9	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	27	10	involves	involve	VBZ
cord-007084-4niom5mw	27	11	the	the	DT
cord-007084-4niom5mw	27	12	active	active	JJ
cord-007084-4niom5mw	27	13	participation	participation	NN
cord-007084-4niom5mw	27	14	of	of	IN
cord-007084-4niom5mw	27	15	cholesterol	cholesterol	NN
cord-007084-4niom5mw	27	16	side	side	NN
cord-007084-4niom5mw	27	17	-	-	HYPH
cord-007084-4niom5mw	27	18	chain	chain	NN
cord-007084-4niom5mw	27	19	cleavage	cleavage	NN
cord-007084-4niom5mw	27	20	,	,	,
cord-007084-4niom5mw	27	21	A	a	DT
cord-007084-4niom5mw	27	22	5	5	CD
cord-007084-4niom5mw	27	23	-3/?-hydroxysteroid	-3/?-hydroxysteroid	NN
cord-007084-4niom5mw	27	24	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	27	25	-	-	HYPH
cord-007084-4niom5mw	27	26	A	a	NN
cord-007084-4niom5mw	27	27	5	5	CD
cord-007084-4niom5mw	27	28	"	"	''
cord-007084-4niom5mw	27	29	4isomerase	4isomerase	CD
cord-007084-4niom5mw	27	30	(	(	-LRB-
cord-007084-4niom5mw	27	31	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	27	32	)	)	-RRB-
cord-007084-4niom5mw	27	33	,	,	,
cord-007084-4niom5mw	27	34	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	27	35	,	,	,
cord-007084-4niom5mw	27	36	and	and	CC
cord-007084-4niom5mw	27	37	11/3-hydroxylase	11/3-hydroxylase	CD
cord-007084-4niom5mw	27	38	activities	activity	NNS
cord-007084-4niom5mw	27	39	(	(	-LRB-
cord-007084-4niom5mw	27	40	2	2	CD
cord-007084-4niom5mw	27	41	)	)	-RRB-
cord-007084-4niom5mw	27	42	(	(	-LRB-
cord-007084-4niom5mw	27	43	3	3	LS
cord-007084-4niom5mw	27	44	)	)	-RRB-
cord-007084-4niom5mw	27	45	(	(	-LRB-
cord-007084-4niom5mw	27	46	4	4	LS
cord-007084-4niom5mw	27	47	)	)	-RRB-
cord-007084-4niom5mw	27	48	(	(	-LRB-
cord-007084-4niom5mw	27	49	5	5	LS
cord-007084-4niom5mw	27	50	)	)	-RRB-
cord-007084-4niom5mw	27	51	(	(	-LRB-
cord-007084-4niom5mw	27	52	6	6	LS
cord-007084-4niom5mw	27	53	)	)	-RRB-
cord-007084-4niom5mw	27	54	(	(	-LRB-
cord-007084-4niom5mw	27	55	7	7	LS
cord-007084-4niom5mw	27	56	)	)	-RRB-
cord-007084-4niom5mw	27	57	(	(	-LRB-
cord-007084-4niom5mw	27	58	8)	8)	NNP
cord-007084-4niom5mw	27	59	.	.	.
cord-007084-4niom5mw	28	1	Among	among	IN
cord-007084-4niom5mw	28	2	these	these	DT
cord-007084-4niom5mw	28	3	,	,	,
cord-007084-4niom5mw	28	4	cholesterol	cholesterol	NN
cord-007084-4niom5mw	28	5	side	side	NN
cord-007084-4niom5mw	28	6	-	-	HYPH
cord-007084-4niom5mw	28	7	chain	chain	NN
cord-007084-4niom5mw	28	8	cleavage	cleavage	NN
cord-007084-4niom5mw	28	9	(	(	-LRB-
cord-007084-4niom5mw	28	10	cytochrome	cytochrome	NN
cord-007084-4niom5mw	28	11	P-450	p-450	NN
cord-007084-4niom5mw	28	12	scc	scc	NNP
cord-007084-4niom5mw	28	13	)	)	-RRB-
cord-007084-4niom5mw	28	14	catalyzes	catalyze	VBZ
cord-007084-4niom5mw	28	15	the	the	DT
cord-007084-4niom5mw	28	16	first	first	JJ
cord-007084-4niom5mw	28	17	step	step	NN
cord-007084-4niom5mw	28	18	in	in	IN
cord-007084-4niom5mw	28	19	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	28	20	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	28	21	(	(	-LRB-
cord-007084-4niom5mw	28	22	i.e.	i.e.	FW
cord-007084-4niom5mw	28	23	the	the	DT
cord-007084-4niom5mw	28	24	conversion	conversion	NN
cord-007084-4niom5mw	28	25	of	of	IN
cord-007084-4niom5mw	28	26	cholesterol	cholesterol	NN
cord-007084-4niom5mw	28	27	to	to	IN
cord-007084-4niom5mw	28	28	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	28	29	)	)	-RRB-
cord-007084-4niom5mw	28	30	and	and	CC
cord-007084-4niom5mw	28	31	is	be	VBZ
cord-007084-4niom5mw	28	32	generally	generally	RB
cord-007084-4niom5mw	28	33	considered	consider	VBN
cord-007084-4niom5mw	28	34	to	to	TO
cord-007084-4niom5mw	28	35	be	be	VB
cord-007084-4niom5mw	28	36	the	the	DT
cord-007084-4niom5mw	28	37	rate	rate	NN
cord-007084-4niom5mw	28	38	-	-	HYPH
cord-007084-4niom5mw	28	39	limiting	limit	VBG
cord-007084-4niom5mw	28	40	step	step	NN
cord-007084-4niom5mw	28	41	in	in	IN
cord-007084-4niom5mw	28	42	steroidogenesis	steroidogenesis	NNP
cord-007084-4niom5mw	28	43	(	(	-LRB-
cord-007084-4niom5mw	28	44	2	2	CD
cord-007084-4niom5mw	28	45	)	)	-RRB-
cord-007084-4niom5mw	29	1	(	(	-LRB-
cord-007084-4niom5mw	29	2	3	3	LS
cord-007084-4niom5mw	29	3	)	)	-RRB-
cord-007084-4niom5mw	29	4	(	(	-LRB-
cord-007084-4niom5mw	29	5	4	4	LS
cord-007084-4niom5mw	29	6	)	)	-RRB-
cord-007084-4niom5mw	29	7	(	(	-LRB-
cord-007084-4niom5mw	29	8	5	5	LS
cord-007084-4niom5mw	29	9	)	)	-RRB-
cord-007084-4niom5mw	29	10	(	(	-LRB-
cord-007084-4niom5mw	29	11	6	6	LS
cord-007084-4niom5mw	29	12	)	)	-RRB-
cord-007084-4niom5mw	29	13	(	(	-LRB-
cord-007084-4niom5mw	29	14	7	7	CD
cord-007084-4niom5mw	29	15	)	)	-RRB-
cord-007084-4niom5mw	29	16	(	(	-LRB-
cord-007084-4niom5mw	30	1	8)	8)	NNP
cord-007084-4niom5mw	30	2	.	.	.
cord-007084-4niom5mw	31	1	Furthermore	furthermore	RB
cord-007084-4niom5mw	31	2	,	,	,
cord-007084-4niom5mw	31	3	the	the	DT
cord-007084-4niom5mw	31	4	levels	level	NNS
cord-007084-4niom5mw	31	5	of	of	IN
cord-007084-4niom5mw	31	6	various	various	JJ
cord-007084-4niom5mw	31	7	steroidogenic	steroidogenic	NN
cord-007084-4niom5mw	31	8	enzyme	enzyme	NN
cord-007084-4niom5mw	31	9	activities	activity	NNS
cord-007084-4niom5mw	31	10	have	have	VBP
cord-007084-4niom5mw	31	11	been	be	VBN
cord-007084-4niom5mw	31	12	shown	show	VBN
cord-007084-4niom5mw	31	13	to	to	TO
cord-007084-4niom5mw	31	14	be	be	VB
cord-007084-4niom5mw	31	15	influenced	influence	VBN
cord-007084-4niom5mw	32	1	and/or	and/or	CC
cord-007084-4niom5mw	32	2	regulated	regulate	VBN
cord-007084-4niom5mw	32	3	by	by	IN
cord-007084-4niom5mw	32	4	ACTH	ACTH	NNP
cord-007084-4niom5mw	32	5	(	(	-LRB-
cord-007084-4niom5mw	32	6	2	2	CD
cord-007084-4niom5mw	32	7	)	)	-RRB-
cord-007084-4niom5mw	32	8	(	(	-LRB-
cord-007084-4niom5mw	32	9	3	3	LS
cord-007084-4niom5mw	32	10	)	)	-RRB-
cord-007084-4niom5mw	32	11	(	(	-LRB-
cord-007084-4niom5mw	32	12	4	4	LS
cord-007084-4niom5mw	32	13	)	)	-RRB-
cord-007084-4niom5mw	32	14	(	(	-LRB-
cord-007084-4niom5mw	32	15	5	5	LS
cord-007084-4niom5mw	32	16	)	)	-RRB-
cord-007084-4niom5mw	32	17	(	(	-LRB-
cord-007084-4niom5mw	32	18	6	6	LS
cord-007084-4niom5mw	32	19	)	)	-RRB-
cord-007084-4niom5mw	32	20	(	(	-LRB-
cord-007084-4niom5mw	32	21	7	7	LS
cord-007084-4niom5mw	32	22	)	)	-RRB-
cord-007084-4niom5mw	32	23	(	(	-LRB-
cord-007084-4niom5mw	32	24	8)	8)	NNP
cord-007084-4niom5mw	32	25	(	(	-LRB-
cord-007084-4niom5mw	32	26	9	9	CD
cord-007084-4niom5mw	32	27	)	)	-RRB-
cord-007084-4niom5mw	32	28	(	(	-LRB-
cord-007084-4niom5mw	32	29	10	10	CD
cord-007084-4niom5mw	32	30	)	)	-RRB-
cord-007084-4niom5mw	32	31	(	(	-LRB-
cord-007084-4niom5mw	32	32	11	11	CD
cord-007084-4niom5mw	32	33	)	)	-RRB-
cord-007084-4niom5mw	32	34	(	(	-LRB-
cord-007084-4niom5mw	32	35	12	12	CD
cord-007084-4niom5mw	32	36	)	)	-RRB-
cord-007084-4niom5mw	32	37	(	(	-LRB-
cord-007084-4niom5mw	32	38	13	13	CD
cord-007084-4niom5mw	32	39	)	)	-RRB-
cord-007084-4niom5mw	32	40	(	(	-LRB-
cord-007084-4niom5mw	32	41	14	14	CD
cord-007084-4niom5mw	32	42	)	)	-RRB-
cord-007084-4niom5mw	32	43	(	(	-LRB-
cord-007084-4niom5mw	32	44	15	15	CD
cord-007084-4niom5mw	32	45	)	)	-RRB-
cord-007084-4niom5mw	32	46	.	.	.
cord-007084-4niom5mw	33	1	Therefore	therefore	RB
cord-007084-4niom5mw	33	2	,	,	,
cord-007084-4niom5mw	33	3	the	the	DT
cord-007084-4niom5mw	33	4	age	age	NN
cord-007084-4niom5mw	33	5	-	-	HYPH
cord-007084-4niom5mw	33	6	related	relate	VBN
cord-007084-4niom5mw	33	7	decline	decline	NN
cord-007084-4niom5mw	33	8	in	in	IN
cord-007084-4niom5mw	33	9	corticosterone	corticosterone	NN
cord-007084-4niom5mw	33	10	secretion	secretion	NN
cord-007084-4niom5mw	33	11	would	would	MD
cord-007084-4niom5mw	33	12	be	be	VB
cord-007084-4niom5mw	33	13	expected	expect	VBN
cord-007084-4niom5mw	33	14	to	to	TO
cord-007084-4niom5mw	33	15	have	have	VB
cord-007084-4niom5mw	33	16	a	a	DT
cord-007084-4niom5mw	33	17	profound	profound	JJ
cord-007084-4niom5mw	33	18	effect	effect	NN
cord-007084-4niom5mw	33	19	on	on	IN
cord-007084-4niom5mw	33	20	the	the	DT
cord-007084-4niom5mw	33	21	activity	activity	NN
cord-007084-4niom5mw	33	22	of	of	IN
cord-007084-4niom5mw	33	23	some	some	DT
cord-007084-4niom5mw	33	24	or	or	CC
cord-007084-4niom5mw	33	25	all	all	DT
cord-007084-4niom5mw	33	26	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	33	27	enzymes	enzyme	NNS
cord-007084-4niom5mw	33	28	.	.	.
cord-007084-4niom5mw	34	1	Moreover	moreover	RB
cord-007084-4niom5mw	34	2	,	,	,
cord-007084-4niom5mw	34	3	this	this	DT
cord-007084-4niom5mw	34	4	age	age	NN
cord-007084-4niom5mw	34	5	-	-	HYPH
cord-007084-4niom5mw	34	6	related	relate	VBN
cord-007084-4niom5mw	34	7	defect	defect	NN
cord-007084-4niom5mw	34	8	may	may	MD
cord-007084-4niom5mw	34	9	,	,	,
cord-007084-4niom5mw	34	10	in	in	IN
cord-007084-4niom5mw	34	11	fact	fact	NN
cord-007084-4niom5mw	34	12	,	,	,
cord-007084-4niom5mw	34	13	result	result	VB
cord-007084-4niom5mw	34	14	from	from	IN
cord-007084-4niom5mw	34	15	alterations	alteration	NNS
cord-007084-4niom5mw	34	16	in	in	IN
cord-007084-4niom5mw	34	17	the	the	DT
cord-007084-4niom5mw	34	18	key	key	JJ
cord-007084-4niom5mw	34	19	enzyme(s	enzyme(s	NN
cord-007084-4niom5mw	34	20	)	)	-RRB-
cord-007084-4niom5mw	34	21	involved	involve	VBN
cord-007084-4niom5mw	34	22	in	in	IN
cord-007084-4niom5mw	34	23	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	34	24	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	34	25	.	.	.
cord-007084-4niom5mw	35	1	The	the	DT
cord-007084-4niom5mw	35	2	present	present	JJ
cord-007084-4niom5mw	35	3	studies	study	NNS
cord-007084-4niom5mw	35	4	were	be	VBD
cord-007084-4niom5mw	35	5	conducted	conduct	VBN
cord-007084-4niom5mw	35	6	,	,	,
cord-007084-4niom5mw	35	7	therefore	therefore	RB
cord-007084-4niom5mw	35	8	,	,	,
cord-007084-4niom5mw	35	9	to	to	TO
cord-007084-4niom5mw	35	10	examine	examine	VB
cord-007084-4niom5mw	35	11	the	the	DT
cord-007084-4niom5mw	35	12	effects	effect	NNS
cord-007084-4niom5mw	35	13	of	of	IN
cord-007084-4niom5mw	35	14	aging	age	VBG
cord-007084-4niom5mw	35	15	on	on	IN
cord-007084-4niom5mw	35	16	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	35	17	enzymes	enzyme	NNS
cord-007084-4niom5mw	35	18	responsible	responsible	JJ
cord-007084-4niom5mw	35	19	for	for	IN
cord-007084-4niom5mw	35	20	the	the	DT
cord-007084-4niom5mw	35	21	production	production	NN
cord-007084-4niom5mw	35	22	of	of	IN
cord-007084-4niom5mw	35	23	corticosterone	corticosterone	NN
cord-007084-4niom5mw	35	24	.	.	.
cord-007084-4niom5mw	36	1	Additionally	additionally	RB
cord-007084-4niom5mw	36	2	,	,	,
cord-007084-4niom5mw	36	3	changes	change	NNS
cord-007084-4niom5mw	36	4	in	in	IN
cord-007084-4niom5mw	36	5	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	36	6	cytochrome	cytochrome	NN
cord-007084-4niom5mw	36	7	P-450	p-450	NN
cord-007084-4niom5mw	36	8	were	be	VBD
cord-007084-4niom5mw	36	9	compared	compare	VBN
cord-007084-4niom5mw	36	10	with	with	IN
cord-007084-4niom5mw	36	11	the	the	DT
cord-007084-4niom5mw	36	12	activity	activity	NN
cord-007084-4niom5mw	36	13	of	of	IN
cord-007084-4niom5mw	36	14	cholesterol	cholesterol	NN
cord-007084-4niom5mw	36	15	side	side	NN
cord-007084-4niom5mw	36	16	-	-	HYPH
cord-007084-4niom5mw	36	17	chain	chain	NN
cord-007084-4niom5mw	36	18	cleavage	cleavage	NN
cord-007084-4niom5mw	36	19	.	.	.
cord-007084-4niom5mw	37	1	Finally	finally	RB
cord-007084-4niom5mw	37	2	,	,	,
cord-007084-4niom5mw	37	3	to	to	TO
cord-007084-4niom5mw	37	4	assess	assess	VB
cord-007084-4niom5mw	37	5	nonspecific	nonspecific	JJ
cord-007084-4niom5mw	37	6	age	age	NN
cord-007084-4niom5mw	37	7	-	-	HYPH
cord-007084-4niom5mw	37	8	related	relate	VBN
cord-007084-4niom5mw	37	9	effects	effect	NNS
cord-007084-4niom5mw	37	10	,	,	,
cord-007084-4niom5mw	37	11	the	the	DT
cord-007084-4niom5mw	37	12	activities	activity	NNS
cord-007084-4niom5mw	37	13	of	of	IN
cord-007084-4niom5mw	37	14	several	several	JJ
cord-007084-4niom5mw	37	15	unrelated	unrelated	JJ
cord-007084-4niom5mw	37	16	enzymes	enzyme	NNS
cord-007084-4niom5mw	37	17	associated	associate	VBN
cord-007084-4niom5mw	37	18	with	with	IN
cord-007084-4niom5mw	37	19	specific	specific	JJ
cord-007084-4niom5mw	37	20	compartments	compartment	NNS
cord-007084-4niom5mw	37	21	of	of	IN
cord-007084-4niom5mw	37	22	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	37	23	were	be	VBD
cord-007084-4niom5mw	37	24	also	also	RB
cord-007084-4niom5mw	37	25	measured	measure	VBN
cord-007084-4niom5mw	37	26	.	.	.
cord-007084-4niom5mw	38	1	[	[	-LRB-
cord-007084-4niom5mw	38	2	7	7	CD
cord-007084-4niom5mw	38	3	-	-	SYM
cord-007084-4niom5mw	38	4	14	14	CD
cord-007084-4niom5mw	38	5	C	c	NN
cord-007084-4niom5mw	38	6	]	]	-RRB-
cord-007084-4niom5mw	39	1	Benzylamine	benzylamine	FW
cord-007084-4niom5mw	39	2	hydrochloride	hydrochloride	NN
cord-007084-4niom5mw	39	3	(	(	-LRB-
cord-007084-4niom5mw	39	4	SA	SA	NNP
cord-007084-4niom5mw	39	5	,	,	,
cord-007084-4niom5mw	39	6	50	50	CD
cord-007084-4niom5mw	39	7	-	-	SYM
cord-007084-4niom5mw	39	8	60	60	CD
cord-007084-4niom5mw	39	9	mCi	mCi	NNS
cord-007084-4niom5mw	39	10	/	/	SYM
cord-007084-4niom5mw	39	11	mmol	mmol	NN
cord-007084-4niom5mw	39	12	)	)	-RRB-
cord-007084-4niom5mw	39	13	and	and	CC
cord-007084-4niom5mw	40	1	[	[	-LRB-
cord-007084-4niom5mw	40	2	l,2-N-	l,2-N-	NNP
cord-007084-4niom5mw	40	3	3	3	CD
cord-007084-4niom5mw	40	4	H]deoxycorticosterone	H]deoxycorticosterone	NNP
cord-007084-4niom5mw	40	5	(	(	-LRB-
cord-007084-4niom5mw	40	6	SA	SA	NNP
cord-007084-4niom5mw	40	7	,	,	,
cord-007084-4niom5mw	40	8	35	35	CD
cord-007084-4niom5mw	40	9	-	-	SYM
cord-007084-4niom5mw	40	10	60	60	CD
cord-007084-4niom5mw	40	11	Ci	ci	NN
cord-007084-4niom5mw	40	12	/	/	SYM
cord-007084-4niom5mw	40	13	mmol	mmol	NN
cord-007084-4niom5mw	40	14	)	)	-RRB-
cord-007084-4niom5mw	40	15	were	be	VBD
cord-007084-4niom5mw	40	16	obtained	obtain	VBN
cord-007084-4niom5mw	40	17	from	from	IN
cord-007084-4niom5mw	40	18	Amersham	Amersham	NNP
cord-007084-4niom5mw	40	19	Corp.	Corp.	NNP
cord-007084-4niom5mw	40	20	(	(	-LRB-
cord-007084-4niom5mw	40	21	Arlington	Arlington	NNP
cord-007084-4niom5mw	40	22	Heights	Heights	NNP
cord-007084-4niom5mw	40	23	,	,	,
cord-007084-4niom5mw	40	24	IL	IL	NNP
cord-007084-4niom5mw	40	25	)	)	-RRB-
cord-007084-4niom5mw	40	26	.	.	.
cord-007084-4niom5mw	41	1	Fatty	fatty	JJ
cord-007084-4niom5mw	41	2	acid	acid	NN
cord-007084-4niom5mw	41	3	-	-	HYPH
cord-007084-4niom5mw	41	4	free	free	JJ
cord-007084-4niom5mw	41	5	BSA	BSA	NNP
cord-007084-4niom5mw	41	6	,	,	,
cord-007084-4niom5mw	41	7	glucose-6phosphate	glucose-6phosphate	NN
cord-007084-4niom5mw	41	8	,	,	,
cord-007084-4niom5mw	41	9	adenine	adenine	NN
cord-007084-4niom5mw	41	10	nucleotides	nucleotide	NNS
cord-007084-4niom5mw	41	11	,	,	,
cord-007084-4niom5mw	41	12	sodium	sodium	NN
cord-007084-4niom5mw	41	13	succinate	succinate	NN
cord-007084-4niom5mw	41	14	,	,	,
cord-007084-4niom5mw	41	15	and	and	CC
cord-007084-4niom5mw	41	16	cytochrome	cytochrome	NN
cord-007084-4niom5mw	41	17	c	c	NN
cord-007084-4niom5mw	41	18	were	be	VBD
cord-007084-4niom5mw	41	19	the	the	DT
cord-007084-4niom5mw	41	20	products	product	NNS
cord-007084-4niom5mw	41	21	of	of	IN
cord-007084-4niom5mw	41	22	Sigma	Sigma	NNP
cord-007084-4niom5mw	41	23	Chemical	Chemical	NNP
cord-007084-4niom5mw	41	24	Co.	Co.	NNP
cord-007084-4niom5mw	41	25	(	(	-LRB-
cord-007084-4niom5mw	41	26	St.	St.	NNP
cord-007084-4niom5mw	41	27	Louis	Louis	NNP
cord-007084-4niom5mw	41	28	,	,	,
cord-007084-4niom5mw	41	29	MO	MO	NNP
cord-007084-4niom5mw	41	30	)	)	-RRB-
cord-007084-4niom5mw	41	31	.	.	.
cord-007084-4niom5mw	42	1	All	all	DT
cord-007084-4niom5mw	42	2	unlabeled	unlabeled	JJ
cord-007084-4niom5mw	42	3	steroids	steroid	NNS
cord-007084-4niom5mw	42	4	were	be	VBD
cord-007084-4niom5mw	42	5	supplied	supply	VBN
cord-007084-4niom5mw	42	6	by	by	IN
cord-007084-4niom5mw	42	7	Research	Research	NNP
cord-007084-4niom5mw	42	8	Plus	Plus	NNP
cord-007084-4niom5mw	42	9	Laboratories	Laboratories	NNP
cord-007084-4niom5mw	42	10	(	(	-LRB-
cord-007084-4niom5mw	42	11	Denville	Denville	NNP
cord-007084-4niom5mw	42	12	,	,	,
cord-007084-4niom5mw	42	13	NJ	NJ	NNP
cord-007084-4niom5mw	42	14	)	)	-RRB-
cord-007084-4niom5mw	42	15	.	.	.
cord-007084-4niom5mw	43	1	5-Cholesten-3j8,25-diol	5-cholesten-3j8,25-diol	LS
cord-007084-4niom5mw	43	2	(	(	-LRB-
cord-007084-4niom5mw	43	3	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	43	4	)	)	-RRB-
cord-007084-4niom5mw	43	5	was	be	VBD
cord-007084-4niom5mw	43	6	purchased	purchase	VBN
cord-007084-4niom5mw	43	7	from	from	IN
cord-007084-4niom5mw	43	8	Steraloids	Steraloids	NNP
cord-007084-4niom5mw	43	9	,	,	,
cord-007084-4niom5mw	44	1	Inc.	Inc.	NNP
cord-007084-4niom5mw	44	2	(	(	-LRB-
cord-007084-4niom5mw	44	3	Wilton	Wilton	NNP
cord-007084-4niom5mw	44	4	,	,	,
cord-007084-4niom5mw	44	5	NY	NY	NNP
cord-007084-4niom5mw	44	6	)	)	-RRB-
cord-007084-4niom5mw	44	7	.	.	.
cord-007084-4niom5mw	45	1	All	all	DT
cord-007084-4niom5mw	45	2	other	other	JJ
cord-007084-4niom5mw	45	3	reagents	reagent	NNS
cord-007084-4niom5mw	45	4	used	use	VBN
cord-007084-4niom5mw	45	5	were	be	VBD
cord-007084-4niom5mw	45	6	of	of	IN
cord-007084-4niom5mw	45	7	analytical	analytical	JJ
cord-007084-4niom5mw	45	8	grade	grade	NN
cord-007084-4niom5mw	45	9	.	.	.
cord-007084-4niom5mw	46	1	Male	male	JJ
cord-007084-4niom5mw	46	2	retired	retire	VBN
cord-007084-4niom5mw	46	3	breeder	breeder	NN
cord-007084-4niom5mw	46	4	Sprague	Sprague	NNP
cord-007084-4niom5mw	46	5	-	-	HYPH
cord-007084-4niom5mw	46	6	Dawley	Dawley	NNP
cord-007084-4niom5mw	46	7	rats	rat	NNS
cord-007084-4niom5mw	46	8	[	[	-LRB-
cord-007084-4niom5mw	46	9	Crl	Crl	NNP
cord-007084-4niom5mw	46	10	:	:	:
cord-007084-4niom5mw	46	11	CoBs	CoBs	NNP
cord-007084-4niom5mw	46	12	CD	CD	NNP
cord-007084-4niom5mw	46	13	(	(	-LRB-
cord-007084-4niom5mw	46	14	SD)BR	SD)BR	NNP
cord-007084-4niom5mw	46	15	]	]	-RRB-
cord-007084-4niom5mw	46	16	,	,	,
cord-007084-4niom5mw	46	17	9	9	CD
cord-007084-4niom5mw	46	18	-	-	SYM
cord-007084-4niom5mw	46	19	10	10	CD
cord-007084-4niom5mw	46	20	months	month	NNS
cord-007084-4niom5mw	46	21	of	of	IN
cord-007084-4niom5mw	46	22	age	age	NN
cord-007084-4niom5mw	46	23	,	,	,
cord-007084-4niom5mw	46	24	were	be	VBD
cord-007084-4niom5mw	46	25	obtained	obtain	VBN
cord-007084-4niom5mw	46	26	from	from	IN
cord-007084-4niom5mw	46	27	Charles	Charles	NNP
cord-007084-4niom5mw	46	28	Rivers	Rivers	NNP
cord-007084-4niom5mw	46	29	Breeding	Breeding	NNP
cord-007084-4niom5mw	46	30	Laboratories	Laboratories	NNP
cord-007084-4niom5mw	46	31	(	(	-LRB-
cord-007084-4niom5mw	46	32	Wilmington	Wilmington	NNP
cord-007084-4niom5mw	46	33	,	,	,
cord-007084-4niom5mw	46	34	MA	MA	NNP
cord-007084-4niom5mw	46	35	)	)	-RRB-
cord-007084-4niom5mw	46	36	and	and	CC
cord-007084-4niom5mw	46	37	allowed	allow	VBN
cord-007084-4niom5mw	46	38	to	to	TO
cord-007084-4niom5mw	46	39	age	age	VB
cord-007084-4niom5mw	46	40	to	to	IN
cord-007084-4niom5mw	46	41	12	12	CD
cord-007084-4niom5mw	46	42	and	and	CC
cord-007084-4niom5mw	46	43	18	18	CD
cord-007084-4niom5mw	46	44	months	month	NNS
cord-007084-4niom5mw	46	45	in	in	IN
cord-007084-4niom5mw	46	46	our	-PRON-	PRP$
cord-007084-4niom5mw	46	47	facility	facility	NN
cord-007084-4niom5mw	46	48	for	for	IN
cord-007084-4niom5mw	46	49	aging	age	VBG
cord-007084-4niom5mw	46	50	animals	animal	NNS
cord-007084-4niom5mw	46	51	,	,	,
cord-007084-4niom5mw	46	52	which	which	WDT
cord-007084-4niom5mw	46	53	is	be	VBZ
cord-007084-4niom5mw	46	54	isolated	isolate	VBN
cord-007084-4niom5mw	46	55	from	from	IN
cord-007084-4niom5mw	46	56	the	the	DT
cord-007084-4niom5mw	46	57	general	general	JJ
cord-007084-4niom5mw	46	58	animal	animal	NN
cord-007084-4niom5mw	46	59	quarters	quarter	NNS
cord-007084-4niom5mw	46	60	in	in	IN
cord-007084-4niom5mw	46	61	this	this	DT
cord-007084-4niom5mw	46	62	V.A.	V.A.	NNP
cord-007084-4niom5mw	46	63	Center	Center	NNP
cord-007084-4niom5mw	46	64	.	.	.
cord-007084-4niom5mw	47	1	Two	two	CD
cord-007084-4niom5mw	47	2	-	-	HYPH
cord-007084-4niom5mw	47	3	month	month	NN
cord-007084-4niom5mw	47	4	-	-	HYPH
cord-007084-4niom5mw	47	5	old	old	JJ
cord-007084-4niom5mw	47	6	rats	rat	NNS
cord-007084-4niom5mw	47	7	of	of	IN
cord-007084-4niom5mw	47	8	the	the	DT
cord-007084-4niom5mw	47	9	same	same	JJ
cord-007084-4niom5mw	47	10	strain	strain	NN
cord-007084-4niom5mw	47	11	were	be	VBD
cord-007084-4niom5mw	47	12	obtained	obtain	VBN
cord-007084-4niom5mw	47	13	from	from	IN
cord-007084-4niom5mw	47	14	the	the	DT
cord-007084-4niom5mw	47	15	same	same	JJ
cord-007084-4niom5mw	47	16	source	source	NN
cord-007084-4niom5mw	47	17	.	.	.
cord-007084-4niom5mw	48	1	The	the	DT
cord-007084-4niom5mw	48	2	rats	rat	NNS
cord-007084-4niom5mw	48	3	were	be	VBD
cord-007084-4niom5mw	48	4	housed	house	VBN
cord-007084-4niom5mw	48	5	under	under	IN
cord-007084-4niom5mw	48	6	conditions	condition	NNS
cord-007084-4niom5mw	48	7	of	of	IN
cord-007084-4niom5mw	48	8	controlled	control	VBN
cord-007084-4niom5mw	48	9	light	light	NN
cord-007084-4niom5mw	48	10	(	(	-LRB-
cord-007084-4niom5mw	48	11	constant	constant	JJ
cord-007084-4niom5mw	48	12	light	light	NN
cord-007084-4niom5mw	48	13	from	from	IN
cord-007084-4niom5mw	48	14	0600	0600	CD
cord-007084-4niom5mw	48	15	-	-	SYM
cord-007084-4niom5mw	48	16	1800	1800	CD
cord-007084-4niom5mw	48	17	h	h	NN
cord-007084-4niom5mw	48	18	each	each	DT
cord-007084-4niom5mw	48	19	day	day	NN
cord-007084-4niom5mw	48	20	)	)	-RRB-
cord-007084-4niom5mw	48	21	and	and	CC
cord-007084-4niom5mw	48	22	temperature	temperature	NN
cord-007084-4niom5mw	48	23	(	(	-LRB-
cord-007084-4niom5mw	48	24	22	22	CD
cord-007084-4niom5mw	48	25	-	-	SYM
cord-007084-4niom5mw	48	26	24	24	CD
cord-007084-4niom5mw	48	27	C	C	NNP
cord-007084-4niom5mw	48	28	)	)	-RRB-
cord-007084-4niom5mw	48	29	and	and	CC
cord-007084-4niom5mw	48	30	given	give	VBN
cord-007084-4niom5mw	48	31	free	free	JJ
cord-007084-4niom5mw	48	32	access	access	NN
cord-007084-4niom5mw	48	33	to	to	IN
cord-007084-4niom5mw	48	34	Purina	Purina	NNP
cord-007084-4niom5mw	48	35	laboratory	laboratory	NN
cord-007084-4niom5mw	48	36	chow	chow	NN
cord-007084-4niom5mw	48	37	(	(	-LRB-
cord-007084-4niom5mw	48	38	no	no	UH
cord-007084-4niom5mw	48	39	.	.	.
cord-007084-4niom5mw	49	1	5012	5012	CD
cord-007084-4niom5mw	49	2	,	,	,
cord-007084-4niom5mw	49	3	Ralston	Ralston	NNP
cord-007084-4niom5mw	49	4	-	-	HYPH
cord-007084-4niom5mw	49	5	Purina	Purina	NNP
cord-007084-4niom5mw	49	6	,	,	,
cord-007084-4niom5mw	49	7	St.	St.	NNP
cord-007084-4niom5mw	49	8	Louis	Louis	NNP
cord-007084-4niom5mw	49	9	,	,	,
cord-007084-4niom5mw	49	10	MO	MO	NNP
cord-007084-4niom5mw	49	11	)	)	-RRB-
cord-007084-4niom5mw	49	12	and	and	CC
cord-007084-4niom5mw	49	13	water	water	NN
cord-007084-4niom5mw	49	14	.	.	.
cord-007084-4niom5mw	50	1	The	the	DT
cord-007084-4niom5mw	50	2	animals	animal	NNS
cord-007084-4niom5mw	50	3	in	in	IN
cord-007084-4niom5mw	50	4	this	this	DT
cord-007084-4niom5mw	50	5	colony	colony	NN
cord-007084-4niom5mw	50	6	are	be	VBP
cord-007084-4niom5mw	50	7	routinely	routinely	RB
cord-007084-4niom5mw	50	8	monitored	monitor	VBN
cord-007084-4niom5mw	50	9	for	for	IN
cord-007084-4niom5mw	50	10	the	the	DT
cord-007084-4niom5mw	50	11	following	follow	VBG
cord-007084-4niom5mw	50	12	viruses	virus	NNS
cord-007084-4niom5mw	50	13	and	and	CC
cord-007084-4niom5mw	50	14	infectious	infectious	JJ
cord-007084-4niom5mw	50	15	agents	agent	NNS
cord-007084-4niom5mw	50	16	:	:	:
cord-007084-4niom5mw	50	17	pneumonia	pneumonia	NN
cord-007084-4niom5mw	50	18	virus	virus	NN
cord-007084-4niom5mw	50	19	of	of	IN
cord-007084-4niom5mw	50	20	mice	mouse	NNS
cord-007084-4niom5mw	50	21	(	(	-LRB-
cord-007084-4niom5mw	50	22	PVM	PVM	NNP
cord-007084-4niom5mw	50	23	)	)	-RRB-
cord-007084-4niom5mw	50	24	,	,	,
cord-007084-4niom5mw	50	25	Rev-3	Rev-3	NNP
cord-007084-4niom5mw	50	26	virus	virus	NN
cord-007084-4niom5mw	50	27	,	,	,
cord-007084-4niom5mw	50	28	encephalomyelitis	encephalomyelitis	NN
cord-007084-4niom5mw	50	29	virus	virus	NN
cord-007084-4niom5mw	50	30	(	(	-LRB-
cord-007084-4niom5mw	50	31	GD	GD	NNP
cord-007084-4niom5mw	50	32	-	-	HYPH
cord-007084-4niom5mw	50	33	V11	V11	NNP
cord-007084-4niom5mw	50	34	)	)	-RRB-
cord-007084-4niom5mw	50	35	,	,	,
cord-007084-4niom5mw	50	36	Sendai	Sendai	NNP
cord-007084-4niom5mw	50	37	virus	virus	NN
cord-007084-4niom5mw	50	38	,	,	,
cord-007084-4niom5mw	50	39	Kilham	Kilham	NNP
cord-007084-4niom5mw	50	40	rat	rat	NN
cord-007084-4niom5mw	50	41	virus	virus	NN
cord-007084-4niom5mw	50	42	,	,	,
cord-007084-4niom5mw	50	43	rat	rat	NNP
cord-007084-4niom5mw	50	44	corona	corona	NNP
cord-007084-4niom5mw	50	45	virus	virus	NN
cord-007084-4niom5mw	50	46	/	/	SYM
cord-007084-4niom5mw	50	47	sialodacryoadenitus	sialodacryoadenitus	NNP
cord-007084-4niom5mw	50	48	(	(	-LRB-
cord-007084-4niom5mw	50	49	RCV	RCV	NNP
cord-007084-4niom5mw	50	50	/	/	SYM
cord-007084-4niom5mw	50	51	SDA	SDA	NNP
cord-007084-4niom5mw	50	52	)	)	-RRB-
cord-007084-4niom5mw	50	53	,	,	,
cord-007084-4niom5mw	50	54	and	and	CC
cord-007084-4niom5mw	50	55	Mycoplasma	Mycoplasma	NNP
cord-007084-4niom5mw	50	56	pulmonis	pulmonis	NNP
cord-007084-4niom5mw	50	57	.	.	.
cord-007084-4niom5mw	51	1	Occasional	occasional	JJ
cord-007084-4niom5mw	51	2	animals	animal	NNS
cord-007084-4niom5mw	51	3	tested	test	VBN
cord-007084-4niom5mw	51	4	positively	positively	RB
cord-007084-4niom5mw	51	5	for	for	IN
cord-007084-4niom5mw	51	6	PVM	PVM	NNP
cord-007084-4niom5mw	51	7	,	,	,
cord-007084-4niom5mw	51	8	h-1	h-1	NN
cord-007084-4niom5mw	51	9	virus	virus	NN
cord-007084-4niom5mw	51	10	and	and	CC
cord-007084-4niom5mw	51	11	REV	REV	NNP
cord-007084-4niom5mw	51	12	/	/	SYM
cord-007084-4niom5mw	51	13	SDA	SDA	NNP
cord-007084-4niom5mw	51	14	,	,	,
cord-007084-4niom5mw	51	15	but	but	CC
cord-007084-4niom5mw	51	16	all	all	DT
cord-007084-4niom5mw	51	17	animals	animal	NNS
cord-007084-4niom5mw	51	18	were	be	VBD
cord-007084-4niom5mw	51	19	negative	negative	JJ
cord-007084-4niom5mw	51	20	for	for	IN
cord-007084-4niom5mw	51	21	the	the	DT
cord-007084-4niom5mw	51	22	remaining	remain	VBG
cord-007084-4niom5mw	51	23	agents	agent	NNS
cord-007084-4niom5mw	51	24	.	.	.
cord-007084-4niom5mw	52	1	Routine	routine	JJ
cord-007084-4niom5mw	52	2	diagnostic	diagnostic	JJ
cord-007084-4niom5mw	52	3	necropsies	necropsy	NNS
cord-007084-4niom5mw	52	4	were	be	VBD
cord-007084-4niom5mw	52	5	not	not	RB
cord-007084-4niom5mw	52	6	performed	perform	VBN
cord-007084-4niom5mw	52	7	.	.	.
cord-007084-4niom5mw	53	1	In	in	IN
cord-007084-4niom5mw	53	2	addition	addition	NN
cord-007084-4niom5mw	53	3	,	,	,
cord-007084-4niom5mw	53	4	animals	animal	NNS
cord-007084-4niom5mw	53	5	were	be	VBD
cord-007084-4niom5mw	53	6	checked	check	VBN
cord-007084-4niom5mw	53	7	for	for	IN
cord-007084-4niom5mw	53	8	gross	gross	JJ
cord-007084-4niom5mw	53	9	pathology	pathology	NN
cord-007084-4niom5mw	53	10	before	before	IN
cord-007084-4niom5mw	53	11	use	use	NN
cord-007084-4niom5mw	53	12	.	.	.
cord-007084-4niom5mw	54	1	Those	those	DT
cord-007084-4niom5mw	54	2	with	with	IN
cord-007084-4niom5mw	54	3	visible	visible	JJ
cord-007084-4niom5mw	54	4	tumors	tumor	NNS
cord-007084-4niom5mw	54	5	or	or	CC
cord-007084-4niom5mw	54	6	apparent	apparent	JJ
cord-007084-4niom5mw	54	7	defects	defect	NNS
cord-007084-4niom5mw	54	8	were	be	VBD
cord-007084-4niom5mw	54	9	discarded	discard	VBN
cord-007084-4niom5mw	54	10	.	.	.
cord-007084-4niom5mw	55	1	Preparation	preparation	NN
cord-007084-4niom5mw	55	2	of	of	IN
cord-007084-4niom5mw	55	3	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	55	4	.	.	.
cord-007084-4niom5mw	56	1	Rats	rat	NNS
cord-007084-4niom5mw	56	2	were	be	VBD
cord-007084-4niom5mw	56	3	killed	kill	VBN
cord-007084-4niom5mw	56	4	by	by	IN
cord-007084-4niom5mw	56	5	cervical	cervical	JJ
cord-007084-4niom5mw	56	6	dislocation	dislocation	NN
cord-007084-4niom5mw	56	7	,	,	,
cord-007084-4niom5mw	56	8	and	and	CC
cord-007084-4niom5mw	56	9	the	the	DT
cord-007084-4niom5mw	56	10	adrenals	adrenal	NNS
cord-007084-4niom5mw	56	11	were	be	VBD
cord-007084-4niom5mw	56	12	rapidly	rapidly	RB
cord-007084-4niom5mw	56	13	removed	remove	VBN
cord-007084-4niom5mw	56	14	and	and	CC
cord-007084-4niom5mw	56	15	trimmed	trim	VBN
cord-007084-4niom5mw	56	16	of	of	IN
cord-007084-4niom5mw	56	17	excess	excess	JJ
cord-007084-4niom5mw	56	18	fat	fat	NN
cord-007084-4niom5mw	56	19	and	and	CC
cord-007084-4niom5mw	56	20	external	external	JJ
cord-007084-4niom5mw	56	21	connective	connective	JJ
cord-007084-4niom5mw	56	22	tissue	tissue	NN
cord-007084-4niom5mw	56	23	.	.	.
cord-007084-4niom5mw	57	1	Adrenal	adrenal	JJ
cord-007084-4niom5mw	57	2	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	57	3	were	be	VBD
cord-007084-4niom5mw	57	4	isolated	isolate	VBN
cord-007084-4niom5mw	57	5	by	by	IN
cord-007084-4niom5mw	57	6	a	a	DT
cord-007084-4niom5mw	57	7	slightly	slightly	RB
cord-007084-4niom5mw	57	8	modified	modify	VBN
cord-007084-4niom5mw	57	9	procedure	procedure	NN
cord-007084-4niom5mw	57	10	of	of	IN
cord-007084-4niom5mw	57	11	Toaff	Toaff	NNP
cord-007084-4niom5mw	57	12	et	et	FW
cord-007084-4niom5mw	57	13	al	al	NNP
cord-007084-4niom5mw	57	14	.	.	.
cord-007084-4niom5mw	58	1	(	(	-LRB-
cord-007084-4niom5mw	58	2	16	16	CD
cord-007084-4niom5mw	58	3	)	)	-RRB-
cord-007084-4niom5mw	58	4	,	,	,
cord-007084-4niom5mw	58	5	as	as	IN
cord-007084-4niom5mw	58	6	described	describe	VBN
cord-007084-4niom5mw	58	7	previously	previously	RB
cord-007084-4niom5mw	58	8	(	(	-LRB-
cord-007084-4niom5mw	58	9	17	17	CD
cord-007084-4niom5mw	58	10	,	,	,
cord-007084-4niom5mw	58	11	18	18	CD
cord-007084-4niom5mw	58	12	)	)	-RRB-
cord-007084-4niom5mw	58	13	.	.	.
cord-007084-4niom5mw	59	1	Briefly	briefly	RB
cord-007084-4niom5mw	59	2	,	,	,
cord-007084-4niom5mw	59	3	adrenals	adrenal	NNS
cord-007084-4niom5mw	59	4	from	from	IN
cord-007084-4niom5mw	59	5	four	four	CD
cord-007084-4niom5mw	59	6	to	to	TO
cord-007084-4niom5mw	59	7	six	six	CD
cord-007084-4niom5mw	59	8	rats	rat	NNS
cord-007084-4niom5mw	59	9	were	be	VBD
cord-007084-4niom5mw	59	10	homogenized	homogenize	VBN
cord-007084-4niom5mw	59	11	in	in	IN
cord-007084-4niom5mw	59	12	5	5	CD
cord-007084-4niom5mw	59	13	times	time	NNS
cord-007084-4niom5mw	59	14	their	-PRON-	PRP$
cord-007084-4niom5mw	59	15	wet	wet	JJ
cord-007084-4niom5mw	59	16	weight	weight	NN
cord-007084-4niom5mw	59	17	of	of	IN
cord-007084-4niom5mw	59	18	ice	ice	NN
cord-007084-4niom5mw	59	19	-	-	HYPH
cord-007084-4niom5mw	59	20	cold	cold	JJ
cord-007084-4niom5mw	59	21	buffer	buffer	NN
cord-007084-4niom5mw	59	22	containing	contain	VBG
cord-007084-4niom5mw	59	23	0.25	0.25	CD
cord-007084-4niom5mw	59	24	M	M	NNP
cord-007084-4niom5mw	59	25	sucrose	sucrose	NN
cord-007084-4niom5mw	59	26	,	,	,
cord-007084-4niom5mw	59	27	1	1	CD
cord-007084-4niom5mw	59	28	mM	mm	CD
cord-007084-4niom5mw	59	29	EDTA	EDTA	NNP
cord-007084-4niom5mw	59	30	,	,	,
cord-007084-4niom5mw	59	31	25	25	CD
cord-007084-4niom5mw	59	32	mM	mm	CD
cord-007084-4niom5mw	59	33	HEPES	HEPES	NNP
cord-007084-4niom5mw	59	34	(	(	-LRB-
cord-007084-4niom5mw	59	35	pH	pH	NNP
cord-007084-4niom5mw	59	36	7.0	7.0	CD
cord-007084-4niom5mw	59	37	)	)	-RRB-
cord-007084-4niom5mw	59	38	and	and	CC
cord-007084-4niom5mw	59	39	10	10	CD
cord-007084-4niom5mw	59	40	mg	mg	NNP
cord-007084-4niom5mw	59	41	/	/	SYM
cord-007084-4niom5mw	59	42	ml	ml	IN
cord-007084-4niom5mw	59	43	fatty	fatty	JJ
cord-007084-4niom5mw	59	44	acid	acid	NN
cord-007084-4niom5mw	59	45	-	-	HYPH
cord-007084-4niom5mw	59	46	free	free	JJ
cord-007084-4niom5mw	59	47	BSA	BSA	NNP
cord-007084-4niom5mw	59	48	(	(	-LRB-
cord-007084-4niom5mw	59	49	buffer	buffer	VB
cord-007084-4niom5mw	59	50	A	A	NNP
cord-007084-4niom5mw	59	51	)	)	-RRB-
cord-007084-4niom5mw	59	52	.	.	.
cord-007084-4niom5mw	60	1	The	the	DT
cord-007084-4niom5mw	60	2	homogenate	homogenate	NNP
cord-007084-4niom5mw	60	3	was	be	VBD
cord-007084-4niom5mw	60	4	then	then	RB
cord-007084-4niom5mw	60	5	centrifuged	centrifuge	VBN
cord-007084-4niom5mw	60	6	at	at	IN
cord-007084-4niom5mw	60	7	600	600	CD
cord-007084-4niom5mw	60	8	X	x	NN
cord-007084-4niom5mw	60	9	g	g	NN
cord-007084-4niom5mw	60	10	(	(	-LRB-
cord-007084-4niom5mw	60	11	JA	JA	NNP
cord-007084-4niom5mw	60	12	20	20	CD
cord-007084-4niom5mw	60	13	rotor	rotor	NN
cord-007084-4niom5mw	60	14	,	,	,
cord-007084-4niom5mw	60	15	Beckman	Beckman	NNP
cord-007084-4niom5mw	60	16	J21	J21	NNP
cord-007084-4niom5mw	60	17	,	,	,
cord-007084-4niom5mw	60	18	Palo	Palo	NNP
cord-007084-4niom5mw	60	19	Alto	Alto	NNP
cord-007084-4niom5mw	60	20	,	,	,
cord-007084-4niom5mw	60	21	CA	CA	NNP
cord-007084-4niom5mw	60	22	)	)	-RRB-
cord-007084-4niom5mw	60	23	for	for	IN
cord-007084-4niom5mw	60	24	10	10	CD
cord-007084-4niom5mw	60	25	min	min	NN
cord-007084-4niom5mw	60	26	to	to	TO
cord-007084-4niom5mw	60	27	remove	remove	VB
cord-007084-4niom5mw	60	28	intact	intact	JJ
cord-007084-4niom5mw	60	29	cells	cell	NNS
cord-007084-4niom5mw	60	30	,	,	,
cord-007084-4niom5mw	60	31	nuclei	nucleus	NNS
cord-007084-4niom5mw	60	32	,	,	,
cord-007084-4niom5mw	60	33	and	and	CC
cord-007084-4niom5mw	60	34	debris	debris	NN
cord-007084-4niom5mw	60	35	.	.	.
cord-007084-4niom5mw	61	1	The	the	DT
cord-007084-4niom5mw	61	2	supernatant	supernatant	NN
cord-007084-4niom5mw	61	3	was	be	VBD
cord-007084-4niom5mw	61	4	then	then	RB
cord-007084-4niom5mw	61	5	subjected	subject	VBN
cord-007084-4niom5mw	61	6	to	to	IN
cord-007084-4niom5mw	61	7	centrifugation	centrifugation	NN
cord-007084-4niom5mw	61	8	at	at	IN
cord-007084-4niom5mw	61	9	8700	8700	CD
cord-007084-4niom5mw	61	10	X	x	NN
cord-007084-4niom5mw	61	11	g	g	NN
cord-007084-4niom5mw	61	12	for	for	IN
cord-007084-4niom5mw	61	13	10	10	CD
cord-007084-4niom5mw	61	14	min	min	NN
cord-007084-4niom5mw	61	15	to	to	TO
cord-007084-4niom5mw	61	16	sediment	sediment	NN
cord-007084-4niom5mw	61	17	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	61	18	.	.	.
cord-007084-4niom5mw	62	1	The	the	DT
cord-007084-4niom5mw	62	2	pellet	pellet	NN
cord-007084-4niom5mw	62	3	(	(	-LRB-
cord-007084-4niom5mw	62	4	sedimented	sedimented	JJ
cord-007084-4niom5mw	62	5	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	62	6	)	)	-RRB-
cord-007084-4niom5mw	62	7	was	be	VBD
cord-007084-4niom5mw	62	8	resuspended	resuspend	VBN
cord-007084-4niom5mw	62	9	in	in	IN
cord-007084-4niom5mw	62	10	buffer	buffer	NN
cord-007084-4niom5mw	62	11	A	A	NNP
cord-007084-4niom5mw	62	12	and	and	CC
cord-007084-4niom5mw	62	13	centrifuged	centrifuge	VBN
cord-007084-4niom5mw	62	14	at	at	IN
cord-007084-4niom5mw	62	15	600	600	CD
cord-007084-4niom5mw	62	16	X	x	NN
cord-007084-4niom5mw	62	17	g	g	NN
cord-007084-4niom5mw	62	18	for	for	IN
cord-007084-4niom5mw	62	19	10	10	CD
cord-007084-4niom5mw	62	20	min	min	NN
cord-007084-4niom5mw	62	21	,	,	,
cord-007084-4niom5mw	62	22	and	and	CC
cord-007084-4niom5mw	62	23	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	62	24	were	be	VBD
cord-007084-4niom5mw	62	25	resedimented	resedimente	VBN
cord-007084-4niom5mw	62	26	at	at	IN
cord-007084-4niom5mw	62	27	8700	8700	CD
cord-007084-4niom5mw	62	28	X	x	NN
cord-007084-4niom5mw	62	29	g	g	NN
cord-007084-4niom5mw	62	30	for	for	IN
cord-007084-4niom5mw	62	31	a	a	DT
cord-007084-4niom5mw	62	32	further	further	JJ
cord-007084-4niom5mw	62	33	10	10	CD
cord-007084-4niom5mw	62	34	min	min	NN
cord-007084-4niom5mw	62	35	.	.	.
cord-007084-4niom5mw	63	1	The	the	DT
cord-007084-4niom5mw	63	2	resulting	result	VBG
cord-007084-4niom5mw	63	3	pellet	pellet	NN
cord-007084-4niom5mw	63	4	was	be	VBD
cord-007084-4niom5mw	63	5	resuspended	resuspend	VBN
cord-007084-4niom5mw	63	6	in	in	IN
cord-007084-4niom5mw	63	7	buffer	buffer	NN
cord-007084-4niom5mw	63	8	B	b	NN
cord-007084-4niom5mw	63	9	(	(	-LRB-
cord-007084-4niom5mw	63	10	0.2	0.2	CD
cord-007084-4niom5mw	63	11	M	m	NN
cord-007084-4niom5mw	63	12	sucrose	sucrose	NN
cord-007084-4niom5mw	63	13	,	,	,
cord-007084-4niom5mw	63	14	20	20	CD
cord-007084-4niom5mw	63	15	mM	mm	CD
cord-007084-4niom5mw	63	16	KC1,5	KC1,5	NNP
cord-007084-4niom5mw	63	17	mM	mM	NNP
cord-007084-4niom5mw	63	18	MgCl	MgCl	NNP
cord-007084-4niom5mw	63	19	2	2	CD
cord-007084-4niom5mw	63	20	,	,	,
cord-007084-4niom5mw	63	21	and	and	CC
cord-007084-4niom5mw	63	22	25	25	CD
cord-007084-4niom5mw	63	23	mM	mm	CD
cord-007084-4niom5mw	63	24	Tris	Tris	NNP
cord-007084-4niom5mw	63	25	-	-	HYPH
cord-007084-4niom5mw	63	26	HCl	HCl	NNP
cord-007084-4niom5mw	63	27	pH	pH	NNP
cord-007084-4niom5mw	63	28	7.4	7.4	CD
cord-007084-4niom5mw	63	29	)	)	-RRB-
cord-007084-4niom5mw	63	30	to	to	IN
cord-007084-4niom5mw	63	31	a	a	DT
cord-007084-4niom5mw	63	32	desired	desire	VBN
cord-007084-4niom5mw	63	33	protein	protein	NN
cord-007084-4niom5mw	63	34	concentration	concentration	NN
cord-007084-4niom5mw	63	35	and	and	CC
cord-007084-4niom5mw	63	36	immediately	immediately	RB
cord-007084-4niom5mw	63	37	used	use	VBD
cord-007084-4niom5mw	63	38	for	for	IN
cord-007084-4niom5mw	63	39	enzyme	enzyme	NN
cord-007084-4niom5mw	63	40	measurements	measurement	NNS
cord-007084-4niom5mw	63	41	.	.	.
cord-007084-4niom5mw	64	1	Preparation	preparation	NN
cord-007084-4niom5mw	64	2	of	of	IN
cord-007084-4niom5mw	64	3	microsomal	microsomal	NNP
cord-007084-4niom5mw	64	4	fraction	fraction	NN
cord-007084-4niom5mw	64	5	.	.	.
cord-007084-4niom5mw	65	1	The	the	DT
cord-007084-4niom5mw	65	2	8,700	8,700	CD
cord-007084-4niom5mw	65	3	X	x	NN
cord-007084-4niom5mw	65	4	g	g	NN
cord-007084-4niom5mw	65	5	supernatant	supernatant	NN
cord-007084-4niom5mw	65	6	was	be	VBD
cord-007084-4niom5mw	65	7	centrifuged	centrifuge	VBN
cord-007084-4niom5mw	65	8	at	at	IN
cord-007084-4niom5mw	65	9	15,000	15,000	CD
cord-007084-4niom5mw	65	10	x	x	SYM
cord-007084-4niom5mw	65	11	g	g	NN
cord-007084-4niom5mw	65	12	for	for	IN
cord-007084-4niom5mw	65	13	15	15	CD
cord-007084-4niom5mw	65	14	min	min	NN
cord-007084-4niom5mw	65	15	,	,	,
cord-007084-4niom5mw	65	16	and	and	CC
cord-007084-4niom5mw	65	17	the	the	DT
cord-007084-4niom5mw	65	18	pellet	pellet	NN
cord-007084-4niom5mw	65	19	was	be	VBD
cord-007084-4niom5mw	65	20	discarded	discard	VBN
cord-007084-4niom5mw	65	21	.	.	.
cord-007084-4niom5mw	66	1	The	the	DT
cord-007084-4niom5mw	66	2	supernatant	supernatant	JJ
cord-007084-4niom5mw	66	3	fraction	fraction	NN
cord-007084-4niom5mw	66	4	was	be	VBD
cord-007084-4niom5mw	66	5	next	next	RB
cord-007084-4niom5mw	66	6	centrifuged	centrifuge	VBN
cord-007084-4niom5mw	66	7	at	at	IN
cord-007084-4niom5mw	66	8	105,000	105,000	CD
cord-007084-4niom5mw	66	9	x	x	SYM
cord-007084-4niom5mw	66	10	g	g	NN
cord-007084-4niom5mw	66	11	for	for	IN
cord-007084-4niom5mw	66	12	60	60	CD
cord-007084-4niom5mw	66	13	min	min	NN
cord-007084-4niom5mw	66	14	(	(	-LRB-
cord-007084-4niom5mw	66	15	60-Ti	60-ti	CD
cord-007084-4niom5mw	66	16	rotor	rotor	NN
cord-007084-4niom5mw	66	17	,	,	,
cord-007084-4niom5mw	66	18	Beckman	Beckman	NNP
cord-007084-4niom5mw	66	19	LM	LM	NNP
cord-007084-4niom5mw	66	20	8	8	CD
cord-007084-4niom5mw	66	21	Ultracentrifuge	Ultracentrifuge	NNP
cord-007084-4niom5mw	66	22	)	)	-RRB-
cord-007084-4niom5mw	66	23	to	to	TO
cord-007084-4niom5mw	66	24	sediment	sediment	VB
cord-007084-4niom5mw	66	25	microsomal	microsomal	NNP
cord-007084-4niom5mw	66	26	fraction	fraction	NN
cord-007084-4niom5mw	66	27	.	.	.
cord-007084-4niom5mw	67	1	The	the	DT
cord-007084-4niom5mw	67	2	pellet	pellet	NN
cord-007084-4niom5mw	67	3	was	be	VBD
cord-007084-4niom5mw	67	4	washed	wash	VBN
cord-007084-4niom5mw	67	5	in	in	IN
cord-007084-4niom5mw	67	6	buffer	buffer	NN
cord-007084-4niom5mw	67	7	A	a	NN
cord-007084-4niom5mw	67	8	(	(	-LRB-
cord-007084-4niom5mw	67	9	without	without	IN
cord-007084-4niom5mw	67	10	BSA	BSA	NNP
cord-007084-4niom5mw	67	11	)	)	-RRB-
cord-007084-4niom5mw	67	12	and	and	CC
cord-007084-4niom5mw	67	13	again	again	RB
cord-007084-4niom5mw	67	14	collected	collect	VBN
cord-007084-4niom5mw	67	15	at	at	IN
cord-007084-4niom5mw	67	16	105,000	105,000	CD
cord-007084-4niom5mw	67	17	X	x	NN
cord-007084-4niom5mw	67	18	g	g	NN
cord-007084-4niom5mw	67	19	for	for	IN
cord-007084-4niom5mw	67	20	60	60	CD
cord-007084-4niom5mw	67	21	min	min	NN
cord-007084-4niom5mw	67	22	.	.	.
cord-007084-4niom5mw	68	1	The	the	DT
cord-007084-4niom5mw	68	2	sediment	sediment	NN
cord-007084-4niom5mw	68	3	was	be	VBD
cord-007084-4niom5mw	68	4	resuspended	resuspend	VBN
cord-007084-4niom5mw	68	5	in	in	IN
cord-007084-4niom5mw	68	6	buffer	buffer	NN
cord-007084-4niom5mw	68	7	C	C	NNP
cord-007084-4niom5mw	68	8	(	(	-LRB-
cord-007084-4niom5mw	68	9	0.25	0.25	CD
cord-007084-4niom5mw	68	10	M	M	NNP
cord-007084-4niom5mw	68	11	sucrose	sucrose	NN
cord-007084-4niom5mw	68	12	,	,	,
cord-007084-4niom5mw	68	13	1	1	CD
cord-007084-4niom5mw	68	14	mM	mm	CD
cord-007084-4niom5mw	68	15	EDTA	EDTA	NNP
cord-007084-4niom5mw	68	16	,	,	,
cord-007084-4niom5mw	68	17	and	and	CC
cord-007084-4niom5mw	68	18	10	10	CD
cord-007084-4niom5mw	68	19	mM	mm	CD
cord-007084-4niom5mw	68	20	potassium	potassium	NN
cord-007084-4niom5mw	68	21	phosphate	phosphate	NN
cord-007084-4niom5mw	68	22	,	,	,
cord-007084-4niom5mw	68	23	pH	pH	NNP
cord-007084-4niom5mw	68	24	7.0	7.0	CD
cord-007084-4niom5mw	68	25	)	)	-RRB-
cord-007084-4niom5mw	68	26	and	and	CC
cord-007084-4niom5mw	68	27	immediately	immediately	RB
cord-007084-4niom5mw	68	28	used	use	VBD
cord-007084-4niom5mw	68	29	for	for	IN
cord-007084-4niom5mw	68	30	enzyme	enzyme	NN
cord-007084-4niom5mw	68	31	assays	assay	NNS
cord-007084-4niom5mw	68	32	.	.	.
cord-007084-4niom5mw	69	1	Assay	assay	NN
cord-007084-4niom5mw	69	2	for	for	IN
cord-007084-4niom5mw	69	3	cholesterol	cholesterol	NN
cord-007084-4niom5mw	69	4	side	side	NN
cord-007084-4niom5mw	69	5	-	-	HYPH
cord-007084-4niom5mw	69	6	chain	chain	NN
cord-007084-4niom5mw	69	7	cleavage	cleavage	NN
cord-007084-4niom5mw	69	8	activity	activity	NN
cord-007084-4niom5mw	69	9	.	.	.
cord-007084-4niom5mw	70	1	The	the	DT
cord-007084-4niom5mw	70	2	enzyme	enzyme	NN
cord-007084-4niom5mw	70	3	activity	activity	NN
cord-007084-4niom5mw	70	4	was	be	VBD
cord-007084-4niom5mw	70	5	measured	measure	VBN
cord-007084-4niom5mw	70	6	by	by	IN
cord-007084-4niom5mw	70	7	a	a	DT
cord-007084-4niom5mw	70	8	slight	slight	JJ
cord-007084-4niom5mw	70	9	modification	modification	NN
cord-007084-4niom5mw	70	10	of	of	IN
cord-007084-4niom5mw	70	11	the	the	DT
cord-007084-4niom5mw	70	12	procedure	procedure	NN
cord-007084-4niom5mw	70	13	of	of	IN
cord-007084-4niom5mw	70	14	Toaff	Toaff	NNP
cord-007084-4niom5mw	70	15	et	et	FW
cord-007084-4niom5mw	70	16	al	al	NNP
cord-007084-4niom5mw	70	17	.	.	.
cord-007084-4niom5mw	71	1	(	(	-LRB-
cord-007084-4niom5mw	71	2	16	16	CD
cord-007084-4niom5mw	71	3	)	)	-RRB-
cord-007084-4niom5mw	71	4	,	,	,
cord-007084-4niom5mw	71	5	as	as	IN
cord-007084-4niom5mw	71	6	described	describe	VBN
cord-007084-4niom5mw	71	7	by	by	IN
cord-007084-4niom5mw	71	8	Mori	Mori	NNP
cord-007084-4niom5mw	71	9	and	and	CC
cord-007084-4niom5mw	71	10	Marsh	Marsh	NNP
cord-007084-4niom5mw	71	11	(	(	-LRB-
cord-007084-4niom5mw	71	12	17	17	CD
cord-007084-4niom5mw	71	13	)	)	-RRB-
cord-007084-4niom5mw	71	14	.	.	.
cord-007084-4niom5mw	72	1	The	the	DT
cord-007084-4niom5mw	72	2	incubation	incubation	NN
cord-007084-4niom5mw	72	3	medium	medium	NN
cord-007084-4niom5mw	72	4	in	in	IN
cord-007084-4niom5mw	72	5	a	a	DT
cord-007084-4niom5mw	72	6	final	final	JJ
cord-007084-4niom5mw	72	7	volume	volume	NN
cord-007084-4niom5mw	72	8	of	of	IN
cord-007084-4niom5mw	72	9	1	1	CD
cord-007084-4niom5mw	72	10	ml	ml	NNS
cord-007084-4niom5mw	72	11	contained	contain	VBD
cord-007084-4niom5mw	72	12	0.2	0.2	CD
cord-007084-4niom5mw	72	13	M	M	NNP
cord-007084-4niom5mw	72	14	sucrose	sucrose	NN
cord-007084-4niom5mw	72	15	,	,	,
cord-007084-4niom5mw	72	16	10	10	CD
cord-007084-4niom5mw	72	17	mM	mM	NNP
cord-007084-4niom5mw	72	18	KC1	KC1	NNP
cord-007084-4niom5mw	72	19	,	,	,
cord-007084-4niom5mw	72	20	5	5	CD
cord-007084-4niom5mw	72	21	mM	mm	CD
cord-007084-4niom5mw	72	22	MgCl	MgCl	NNP
cord-007084-4niom5mw	72	23	2	2	CD
cord-007084-4niom5mw	72	24	,	,	,
cord-007084-4niom5mw	72	25	0.2	0.2	CD
cord-007084-4niom5mw	72	26	mM	mm	CD
cord-007084-4niom5mw	72	27	EDTA	EDTA	NNP
cord-007084-4niom5mw	72	28	,	,	,
cord-007084-4niom5mw	72	29	10	10	CD
cord-007084-4niom5mw	72	30	mM	mm	CD
cord-007084-4niom5mw	72	31	potassium	potassium	NN
cord-007084-4niom5mw	72	32	phosphate	phosphate	NN
cord-007084-4niom5mw	72	33	,	,	,
cord-007084-4niom5mw	72	34	25	25	CD
cord-007084-4niom5mw	72	35	mM	mm	CD
cord-007084-4niom5mw	72	36	Tris	Tris	NNP
cord-007084-4niom5mw	72	37	-	-	HYPH
cord-007084-4niom5mw	72	38	HCl	HCl	NNP
cord-007084-4niom5mw	72	39	(	(	-LRB-
cord-007084-4niom5mw	72	40	pH	pH	NNP
cord-007084-4niom5mw	72	41	7.4	7.4	CD
cord-007084-4niom5mw	72	42	)	)	-RRB-
cord-007084-4niom5mw	72	43	,	,	,
cord-007084-4niom5mw	72	44	1	1	CD
cord-007084-4niom5mw	72	45	mg	mg	NNP
cord-007084-4niom5mw	72	46	/	/	SYM
cord-007084-4niom5mw	72	47	ml	ml	NNP
cord-007084-4niom5mw	72	48	BSA	BSA	NNP
cord-007084-4niom5mw	72	49	(	(	-LRB-
cord-007084-4niom5mw	72	50	essentially	essentially	RB
cord-007084-4niom5mw	72	51	fatty	fatty	JJ
cord-007084-4niom5mw	72	52	acid	acid	NN
cord-007084-4niom5mw	72	53	free	free	JJ
cord-007084-4niom5mw	72	54	)	)	-RRB-
cord-007084-4niom5mw	72	55	,	,	,
cord-007084-4niom5mw	72	56	3	3	CD
cord-007084-4niom5mw	72	57	mM	mm	CD
cord-007084-4niom5mw	72	58	sodium	sodium	NN
cord-007084-4niom5mw	72	59	succinate	succinate	NN
cord-007084-4niom5mw	72	60	,	,	,
cord-007084-4niom5mw	72	61	6	6	CD
cord-007084-4niom5mw	72	62	ftM	ftm	ADD
cord-007084-4niom5mw	72	63	cyanoketone	cyanoketone	NN
cord-007084-4niom5mw	72	64	,	,	,
cord-007084-4niom5mw	72	65	and	and	CC
cord-007084-4niom5mw	72	66	a	a	DT
cord-007084-4niom5mw	72	67	suitable	suitable	JJ
cord-007084-4niom5mw	72	68	aliquot	aliquot	NN
cord-007084-4niom5mw	72	69	of	of	IN
cord-007084-4niom5mw	72	70	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	72	71	preparation	preparation	NN
cord-007084-4niom5mw	72	72	(	(	-LRB-
cord-007084-4niom5mw	72	73	50	50	CD
cord-007084-4niom5mw	72	74	-	-	SYM
cord-007084-4niom5mw	72	75	100	100	CD
cord-007084-4niom5mw	72	76	^tg	^tg	NNP
cord-007084-4niom5mw	72	77	protein	protein	NN
cord-007084-4niom5mw	72	78	/	/	SYM
cord-007084-4niom5mw	72	79	ml	ml	NN
cord-007084-4niom5mw	72	80	)	)	-RRB-
cord-007084-4niom5mw	72	81	in	in	IN
cord-007084-4niom5mw	72	82	the	the	DT
cord-007084-4niom5mw	72	83	presence	presence	NN
cord-007084-4niom5mw	72	84	or	or	CC
cord-007084-4niom5mw	72	85	absence	absence	NN
cord-007084-4niom5mw	72	86	of	of	IN
cord-007084-4niom5mw	72	87	25hydroxycholesterol	25hydroxycholesterol	CD
cord-007084-4niom5mw	72	88	(	(	-LRB-
cord-007084-4niom5mw	72	89	25	25	CD
cord-007084-4niom5mw	72	90	/ng	/ng	NNPS
cord-007084-4niom5mw	72	91	/	/	SYM
cord-007084-4niom5mw	72	92	ml	ml	NN
cord-007084-4niom5mw	72	93	)	)	-RRB-
cord-007084-4niom5mw	72	94	.	.	.
cord-007084-4niom5mw	73	1	After	after	IN
cord-007084-4niom5mw	73	2	incubation	incubation	NN
cord-007084-4niom5mw	73	3	at	at	IN
cord-007084-4niom5mw	73	4	37	37	CD
cord-007084-4niom5mw	73	5	C	c	NN
cord-007084-4niom5mw	73	6	for	for	IN
cord-007084-4niom5mw	73	7	5	5	CD
cord-007084-4niom5mw	73	8	-	-	SYM
cord-007084-4niom5mw	73	9	10	10	CD
cord-007084-4niom5mw	73	10	min	min	NN
cord-007084-4niom5mw	73	11	,	,	,
cord-007084-4niom5mw	73	12	the	the	DT
cord-007084-4niom5mw	73	13	reaction	reaction	NN
cord-007084-4niom5mw	73	14	was	be	VBD
cord-007084-4niom5mw	73	15	terminated	terminate	VBN
cord-007084-4niom5mw	73	16	by	by	IN
cord-007084-4niom5mw	73	17	quick	quick	JJ
cord-007084-4niom5mw	73	18	freezing	freezing	NN
cord-007084-4niom5mw	73	19	at	at	IN
cord-007084-4niom5mw	73	20	-60	-60	NNS
cord-007084-4niom5mw	73	21	C.	c.	NN
cord-007084-4niom5mw	74	1	The	the	DT
cord-007084-4niom5mw	74	2	reaction	reaction	NN
cord-007084-4niom5mw	74	3	product	product	NN
cord-007084-4niom5mw	74	4	,	,	,
cord-007084-4niom5mw	74	5	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	74	6	,	,	,
cord-007084-4niom5mw	74	7	was	be	VBD
cord-007084-4niom5mw	74	8	extracted	extract	VBN
cord-007084-4niom5mw	74	9	from	from	IN
cord-007084-4niom5mw	74	10	the	the	DT
cord-007084-4niom5mw	74	11	incubation	incubation	NN
cord-007084-4niom5mw	74	12	mixture	mixture	NN
cord-007084-4niom5mw	74	13	with	with	IN
cord-007084-4niom5mw	74	14	hexane	hexane	NN
cord-007084-4niom5mw	74	15	(	(	-LRB-
cord-007084-4niom5mw	74	16	three	three	CD
cord-007084-4niom5mw	74	17	times	time	NNS
cord-007084-4niom5mw	74	18	,	,	,
cord-007084-4niom5mw	74	19	2	2	CD
cord-007084-4niom5mw	74	20	ml	ml	NN
cord-007084-4niom5mw	74	21	each	each	DT
cord-007084-4niom5mw	74	22	)	)	-RRB-
cord-007084-4niom5mw	74	23	and	and	CC
cord-007084-4niom5mw	74	24	assayed	assay	VBN
cord-007084-4niom5mw	74	25	by	by	IN
cord-007084-4niom5mw	74	26	specific	specific	JJ
cord-007084-4niom5mw	74	27	RIA	RIA	NNP
cord-007084-4niom5mw	74	28	(	(	-LRB-
cord-007084-4niom5mw	74	29	19	19	CD
cord-007084-4niom5mw	74	30	)	)	-RRB-
cord-007084-4niom5mw	74	31	.	.	.
cord-007084-4niom5mw	75	1	Cyanoketone	Cyanoketone	NNP
cord-007084-4niom5mw	75	2	was	be	VBD
cord-007084-4niom5mw	75	3	included	include	VBN
cord-007084-4niom5mw	75	4	to	to	TO
cord-007084-4niom5mw	75	5	inhibit	inhibit	VB
cord-007084-4niom5mw	75	6	further	further	JJ
cord-007084-4niom5mw	75	7	metabolism	metabolism	NN
cord-007084-4niom5mw	75	8	of	of	IN
cord-007084-4niom5mw	75	9	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	75	10	to	to	IN
cord-007084-4niom5mw	75	11	progesterone	progesterone	NN
cord-007084-4niom5mw	75	12	.	.	.
cord-007084-4niom5mw	76	1	All	all	DT
cord-007084-4niom5mw	76	2	assays	assay	NNS
cord-007084-4niom5mw	76	3	were	be	VBD
cord-007084-4niom5mw	76	4	run	run	VBN
cord-007084-4niom5mw	76	5	in	in	IN
cord-007084-4niom5mw	76	6	triplicate	triplicate	NN
cord-007084-4niom5mw	76	7	.	.	.
cord-007084-4niom5mw	77	1	The	the	DT
cord-007084-4niom5mw	77	2	cholesterol	cholesterol	NN
cord-007084-4niom5mw	77	3	side	side	NN
cord-007084-4niom5mw	77	4	-	-	HYPH
cord-007084-4niom5mw	77	5	chain	chain	NN
cord-007084-4niom5mw	77	6	cleavage	cleavage	NN
cord-007084-4niom5mw	77	7	activity	activity	NN
cord-007084-4niom5mw	77	8	is	be	VBZ
cord-007084-4niom5mw	77	9	expressed	express	VBN
cord-007084-4niom5mw	77	10	as	as	IN
cord-007084-4niom5mw	77	11	nanomoles	nanomole	NNS
cord-007084-4niom5mw	77	12	of	of	IN
cord-007084-4niom5mw	77	13	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	77	14	formed	form	VBN
cord-007084-4niom5mw	77	15	per	per	IN
cord-007084-4niom5mw	77	16	min	min	NNP
cord-007084-4niom5mw	77	17	mg	mg	NNP
cord-007084-4niom5mw	77	18	protein	protein	NN
cord-007084-4niom5mw	77	19	"	"	''
cord-007084-4niom5mw	77	20	1	1	CD
cord-007084-4niom5mw	77	21	.	.	.
cord-007084-4niom5mw	78	1	Assay	Assay	NNP
cord-007084-4niom5mw	78	2	for	for	IN
cord-007084-4niom5mw	78	3	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	78	4	.	.	.
cord-007084-4niom5mw	79	1	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	79	2	activity	activity	NN
cord-007084-4niom5mw	79	3	was	be	VBD
cord-007084-4niom5mw	79	4	determined	determine	VBN
cord-007084-4niom5mw	79	5	by	by	IN
cord-007084-4niom5mw	79	6	measuring	measure	VBG
cord-007084-4niom5mw	79	7	the	the	DT
cord-007084-4niom5mw	79	8	conversion	conversion	NN
cord-007084-4niom5mw	79	9	of	of	IN
cord-007084-4niom5mw	79	10	[	[	-LRB-
cord-007084-4niom5mw	79	11	3	3	CD
cord-007084-4niom5mw	79	12	H]pregnenolone	H]pregnenolone	NNP
cord-007084-4niom5mw	79	13	to	to	IN
cord-007084-4niom5mw	79	14	[	[	-LRB-
cord-007084-4niom5mw	79	15	3	3	CD
cord-007084-4niom5mw	79	16	H]progesterone	H]progesterone	NNP
cord-007084-4niom5mw	79	17	as	as	IN
cord-007084-4niom5mw	79	18	described	describe	VBN
cord-007084-4niom5mw	79	19	by	by	IN
cord-007084-4niom5mw	79	20	Shaw	Shaw	NNP
cord-007084-4niom5mw	79	21	et	et	NNP
cord-007084-4niom5mw	79	22	al	al	NNP
cord-007084-4niom5mw	79	23	.	.	.
cord-007084-4niom5mw	80	1	(	(	-LRB-
cord-007084-4niom5mw	80	2	20	20	CD
cord-007084-4niom5mw	80	3	)	)	-RRB-
cord-007084-4niom5mw	80	4	.	.	.
cord-007084-4niom5mw	81	1	Briefly	briefly	RB
cord-007084-4niom5mw	81	2	,	,	,
cord-007084-4niom5mw	81	3	incubation	incubation	NN
cord-007084-4niom5mw	81	4	medium	medium	NN
cord-007084-4niom5mw	81	5	in	in	IN
cord-007084-4niom5mw	81	6	a	a	DT
cord-007084-4niom5mw	81	7	final	final	JJ
cord-007084-4niom5mw	81	8	volume	volume	NN
cord-007084-4niom5mw	81	9	of	of	IN
cord-007084-4niom5mw	81	10	1.0	1.0	CD
cord-007084-4niom5mw	81	11	ml	ml	NNS
cord-007084-4niom5mw	81	12	contained	contain	VBD
cord-007084-4niom5mw	81	13	50	50	CD
cord-007084-4niom5mw	81	14	mM	mm	CD
cord-007084-4niom5mw	81	15	potassium	potassium	NN
cord-007084-4niom5mw	81	16	phosphate	phosphate	NN
cord-007084-4niom5mw	81	17	buffer	buffer	NN
cord-007084-4niom5mw	81	18	(	(	-LRB-
cord-007084-4niom5mw	81	19	pH	pH	NNP
cord-007084-4niom5mw	81	20	7.4	7.4	CD
cord-007084-4niom5mw	81	21	)	)	-RRB-
cord-007084-4niom5mw	81	22	,	,	,
cord-007084-4niom5mw	81	23	50	50	CD
cord-007084-4niom5mw	81	24	nM	nm	CD
cord-007084-4niom5mw	81	25	[	[	-LRB-
cord-007084-4niom5mw	81	26	3	3	CD
cord-007084-4niom5mw	81	27	H]pregnenolone	H]pregnenolone	NNP
cord-007084-4niom5mw	81	28	(	(	-LRB-
cord-007084-4niom5mw	81	29	400	400	CD
cord-007084-4niom5mw	81	30	dpm	dpm	NNP
cord-007084-4niom5mw	81	31	/	/	SYM
cord-007084-4niom5mw	81	32	pmol	pmol	NNP
cord-007084-4niom5mw	81	33	)	)	-RRB-
cord-007084-4niom5mw	81	34	,	,	,
cord-007084-4niom5mw	81	35	0.5	0.5	CD
cord-007084-4niom5mw	81	36	mM	mm	CD
cord-007084-4niom5mw	81	37	NAD	NAD	NNP
cord-007084-4niom5mw	81	38	+	+	CC
cord-007084-4niom5mw	81	39	,	,	,
cord-007084-4niom5mw	81	40	and	and	CC
cord-007084-4niom5mw	81	41	a	a	DT
cord-007084-4niom5mw	81	42	suitable	suitable	JJ
cord-007084-4niom5mw	81	43	aliquot	aliquot	NN
cord-007084-4niom5mw	81	44	of	of	IN
cord-007084-4niom5mw	81	45	microsomal	microsomal	NNP
cord-007084-4niom5mw	81	46	fraction	fraction	NN
cord-007084-4niom5mw	81	47	.	.	.
cord-007084-4niom5mw	82	1	The	the	DT
cord-007084-4niom5mw	82	2	reaction	reaction	NN
cord-007084-4niom5mw	82	3	,	,	,
cord-007084-4niom5mw	82	4	maintained	maintain	VBD
cord-007084-4niom5mw	82	5	at	at	IN
cord-007084-4niom5mw	82	6	37	37	CD
cord-007084-4niom5mw	82	7	C	c	NN
cord-007084-4niom5mw	82	8	for	for	IN
cord-007084-4niom5mw	82	9	15	15	CD
cord-007084-4niom5mw	82	10	-	-	SYM
cord-007084-4niom5mw	82	11	30	30	CD
cord-007084-4niom5mw	82	12	min	min	NN
cord-007084-4niom5mw	82	13	,	,	,
cord-007084-4niom5mw	82	14	was	be	VBD
cord-007084-4niom5mw	82	15	initiated	initiate	VBN
cord-007084-4niom5mw	82	16	by	by	IN
cord-007084-4niom5mw	82	17	the	the	DT
cord-007084-4niom5mw	82	18	addition	addition	NN
cord-007084-4niom5mw	82	19	of	of	IN
cord-007084-4niom5mw	82	20	[	[	-LRB-
cord-007084-4niom5mw	82	21	3	3	CD
cord-007084-4niom5mw	82	22	H]pregnenolone	H]pregnenolone	NNP
cord-007084-4niom5mw	82	23	(	(	-LRB-
cord-007084-4niom5mw	82	24	dissolved	dissolve	VBN
cord-007084-4niom5mw	82	25	in	in	IN
cord-007084-4niom5mw	82	26	30	30	CD
cord-007084-4niom5mw	82	27	n\	n\	NN
cord-007084-4niom5mw	82	28	dimethylsulfoxide	dimethylsulfoxide	NN
cord-007084-4niom5mw	82	29	)	)	-RRB-
cord-007084-4niom5mw	82	30	.	.	.
cord-007084-4niom5mw	83	1	The	the	DT
cord-007084-4niom5mw	83	2	reaction	reaction	NN
cord-007084-4niom5mw	83	3	was	be	VBD
cord-007084-4niom5mw	83	4	stopped	stop	VBN
cord-007084-4niom5mw	83	5	by	by	IN
cord-007084-4niom5mw	83	6	the	the	DT
cord-007084-4niom5mw	83	7	addition	addition	NN
cord-007084-4niom5mw	83	8	of	of	IN
cord-007084-4niom5mw	83	9	0.1	0.1	CD
cord-007084-4niom5mw	83	10	ml	ml	NN
cord-007084-4niom5mw	83	11	1	1	CD
cord-007084-4niom5mw	83	12	N	N	NNP
cord-007084-4niom5mw	83	13	NaOH	NaOH	NNP
cord-007084-4niom5mw	83	14	,	,	,
cord-007084-4niom5mw	83	15	and	and	CC
cord-007084-4niom5mw	83	16	unlabeled	unlabeled	JJ
cord-007084-4niom5mw	83	17	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	83	18	(	(	-LRB-
cord-007084-4niom5mw	83	19	50	50	CD
cord-007084-4niom5mw	83	20	ng	ng	NN
cord-007084-4niom5mw	83	21	)	)	-RRB-
cord-007084-4niom5mw	83	22	and	and	CC
cord-007084-4niom5mw	83	23	progesterone	progesterone	NN
cord-007084-4niom5mw	83	24	(	(	-LRB-
cord-007084-4niom5mw	83	25	50	50	CD
cord-007084-4niom5mw	83	26	fig	fig	NN
cord-007084-4niom5mw	83	27	)	)	-RRB-
cord-007084-4niom5mw	83	28	were	be	VBD
cord-007084-4niom5mw	83	29	added	add	VBN
cord-007084-4niom5mw	83	30	in	in	IN
cord-007084-4niom5mw	83	31	addition	addition	NN
cord-007084-4niom5mw	83	32	to	to	IN
cord-007084-4niom5mw	83	33	[	[	-LRB-
cord-007084-4niom5mw	83	34	14	14	CD
cord-007084-4niom5mw	83	35	C]progesterone	C]progesterone	NNP
cord-007084-4niom5mw	83	36	(	(	-LRB-
cord-007084-4niom5mw	83	37	5000	5000	CD
cord-007084-4niom5mw	83	38	dpm	dpm	NNP
cord-007084-4niom5mw	83	39	)	)	-RRB-
cord-007084-4niom5mw	83	40	to	to	TO
cord-007084-4niom5mw	83	41	monitor	monitor	VB
cord-007084-4niom5mw	83	42	recovery	recovery	NN
cord-007084-4niom5mw	83	43	.	.	.
cord-007084-4niom5mw	84	1	The	the	DT
cord-007084-4niom5mw	84	2	steroids	steroid	NNS
cord-007084-4niom5mw	84	3	were	be	VBD
cord-007084-4niom5mw	84	4	extracted	extract	VBN
cord-007084-4niom5mw	84	5	two	two	CD
cord-007084-4niom5mw	84	6	times	time	NNS
cord-007084-4niom5mw	84	7	with	with	IN
cord-007084-4niom5mw	84	8	5	5	CD
cord-007084-4niom5mw	84	9	ml	ml	NN
cord-007084-4niom5mw	84	10	diethyl	diethyl	NN
cord-007084-4niom5mw	84	11	ether	ether	NN
cord-007084-4niom5mw	84	12	,	,	,
cord-007084-4niom5mw	84	13	and	and	CC
cord-007084-4niom5mw	84	14	pooled	pool	VBD
cord-007084-4niom5mw	84	15	diethyl	diethyl	NN
cord-007084-4niom5mw	84	16	ether	ether	NN
cord-007084-4niom5mw	84	17	extracts	extract	NNS
cord-007084-4niom5mw	84	18	were	be	VBD
cord-007084-4niom5mw	84	19	dried	dry	VBN
cord-007084-4niom5mw	84	20	under	under	IN
cord-007084-4niom5mw	84	21	N	n	CD
cord-007084-4niom5mw	84	22	2	2	CD
cord-007084-4niom5mw	84	23	.	.	.
cord-007084-4niom5mw	85	1	Pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	85	2	and	and	CC
cord-007084-4niom5mw	85	3	progesterone	progesterone	NN
cord-007084-4niom5mw	85	4	were	be	VBD
cord-007084-4niom5mw	85	5	separated	separate	VBN
cord-007084-4niom5mw	85	6	by	by	IN
cord-007084-4niom5mw	85	7	ascending	ascend	VBG
cord-007084-4niom5mw	85	8	TLC	TLC	NNP
cord-007084-4niom5mw	85	9	on	on	IN
cord-007084-4niom5mw	85	10	silica	silica	NN
cord-007084-4niom5mw	85	11	gel	gel	NN
cord-007084-4niom5mw	85	12	H	h	NN
cord-007084-4niom5mw	85	13	using	use	VBG
cord-007084-4niom5mw	85	14	chloroformdiethyl	chloroformdiethyl	JJ
cord-007084-4niom5mw	85	15	ether	ether	NN
cord-007084-4niom5mw	85	16	(	(	-LRB-
cord-007084-4niom5mw	85	17	5:1	5:1	CD
cord-007084-4niom5mw	85	18	,	,	,
cord-007084-4niom5mw	85	19	vol	vol	NNP
cord-007084-4niom5mw	85	20	/	/	SYM
cord-007084-4niom5mw	85	21	vol	vol	NN
cord-007084-4niom5mw	85	22	)	)	-RRB-
cord-007084-4niom5mw	85	23	as	as	IN
cord-007084-4niom5mw	85	24	a	a	DT
cord-007084-4niom5mw	85	25	solvent	solvent	NN
cord-007084-4niom5mw	85	26	system	system	NN
cord-007084-4niom5mw	85	27	.	.	.
cord-007084-4niom5mw	86	1	The	the	DT
cord-007084-4niom5mw	86	2	radioactivity	radioactivity	NN
cord-007084-4niom5mw	86	3	associated	associate	VBN
cord-007084-4niom5mw	86	4	with	with	IN
cord-007084-4niom5mw	86	5	progesterone	progesterone	NN
cord-007084-4niom5mw	86	6	was	be	VBD
cord-007084-4niom5mw	86	7	measured	measure	VBN
cord-007084-4niom5mw	86	8	by	by	IN
cord-007084-4niom5mw	86	9	liquid	liquid	JJ
cord-007084-4niom5mw	86	10	scintillation	scintillation	NN
cord-007084-4niom5mw	86	11	spectrometry	spectrometry	NN
cord-007084-4niom5mw	86	12	(	(	-LRB-
cord-007084-4niom5mw	86	13	Beckman	Beckman	NNP
cord-007084-4niom5mw	86	14	LS3801	LS3801	NNP
cord-007084-4niom5mw	86	15	scintillation	scintillation	NN
cord-007084-4niom5mw	86	16	counter	counter	RB
cord-007084-4niom5mw	86	17	)	)	-RRB-
cord-007084-4niom5mw	86	18	.	.	.
cord-007084-4niom5mw	87	1	The	the	DT
cord-007084-4niom5mw	87	2	purity	purity	NN
cord-007084-4niom5mw	87	3	of	of	IN
cord-007084-4niom5mw	87	4	the	the	DT
cord-007084-4niom5mw	87	5	[	[	-LRB-
cord-007084-4niom5mw	87	6	3	3	CD
cord-007084-4niom5mw	87	7	H]progesterone	H]progesterone	NNP
cord-007084-4niom5mw	87	8	was	be	VBD
cord-007084-4niom5mw	87	9	determined	determine	VBN
cord-007084-4niom5mw	87	10	by	by	IN
cord-007084-4niom5mw	87	11	repeated	repeat	VBN
cord-007084-4niom5mw	87	12	recrystallization	recrystallization	NN
cord-007084-4niom5mw	87	13	.	.	.
cord-007084-4niom5mw	88	1	All	all	DT
cord-007084-4niom5mw	88	2	enzyme	enzyme	NN
cord-007084-4niom5mw	88	3	assays	assay	NNS
cord-007084-4niom5mw	88	4	were	be	VBD
cord-007084-4niom5mw	88	5	carried	carry	VBN
cord-007084-4niom5mw	88	6	out	out	RP
cord-007084-4niom5mw	88	7	in	in	IN
cord-007084-4niom5mw	88	8	triplicate	triplicate	NN
cord-007084-4niom5mw	88	9	.	.	.
cord-007084-4niom5mw	89	1	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	89	2	activity	activity	NN
cord-007084-4niom5mw	89	3	is	be	VBZ
cord-007084-4niom5mw	89	4	expressed	express	VBN
cord-007084-4niom5mw	89	5	as	as	IN
cord-007084-4niom5mw	89	6	nanomoles	nanomole	NNS
cord-007084-4niom5mw	89	7	of	of	IN
cord-007084-4niom5mw	89	8	progesterone	progesterone	NN
cord-007084-4niom5mw	89	9	produced	produce	VBN
cord-007084-4niom5mw	89	10	per	per	IN
cord-007084-4niom5mw	89	11	min	min	NNP
cord-007084-4niom5mw	89	12	mg	mg	NNP
cord-007084-4niom5mw	89	13	protein	protein	NN
cord-007084-4niom5mw	89	14	"	"	''
cord-007084-4niom5mw	89	15	1	1	CD
cord-007084-4niom5mw	89	16	.	.	.
cord-007084-4niom5mw	90	1	Assay	assay	NN
cord-007084-4niom5mw	90	2	for	for	IN
cord-007084-4niom5mw	90	3	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	90	4	activity	activity	NN
cord-007084-4niom5mw	90	5	.	.	.
cord-007084-4niom5mw	91	1	Enzyme	enzyme	NN
cord-007084-4niom5mw	91	2	activity	activity	NN
cord-007084-4niom5mw	91	3	was	be	VBD
cord-007084-4niom5mw	91	4	determined	determine	VBN
cord-007084-4niom5mw	91	5	by	by	IN
cord-007084-4niom5mw	91	6	measuring	measure	VBG
cord-007084-4niom5mw	91	7	the	the	DT
cord-007084-4niom5mw	91	8	formation	formation	NN
cord-007084-4niom5mw	91	9	of	of	IN
cord-007084-4niom5mw	91	10	[	[	-LRB-
cord-007084-4niom5mw	91	11	14	14	CD
cord-007084-4niom5mw	91	12	C]deoxycorticosterone	C]deoxycorticosterone	NNP
cord-007084-4niom5mw	91	13	from	from	IN
cord-007084-4niom5mw	91	14	[	[	-LRB-
cord-007084-4niom5mw	91	15	14	14	CD
cord-007084-4niom5mw	91	16	C]progesterone	C]progesterone	NNP
cord-007084-4niom5mw	91	17	according	accord	VBG
cord-007084-4niom5mw	91	18	to	to	IN
cord-007084-4niom5mw	91	19	the	the	DT
cord-007084-4niom5mw	91	20	procedure	procedure	NN
cord-007084-4niom5mw	91	21	of	of	IN
cord-007084-4niom5mw	91	22	Menard	Menard	NNP
cord-007084-4niom5mw	91	23	et	et	NNP
cord-007084-4niom5mw	91	24	al	al	NNP
cord-007084-4niom5mw	91	25	.	.	.
cord-007084-4niom5mw	92	1	(	(	-LRB-
cord-007084-4niom5mw	92	2	21	21	CD
cord-007084-4niom5mw	92	3	)	)	-RRB-
cord-007084-4niom5mw	92	4	.	.	.
cord-007084-4niom5mw	93	1	All	all	DT
cord-007084-4niom5mw	93	2	incubations	incubation	NNS
cord-007084-4niom5mw	93	3	were	be	VBD
cord-007084-4niom5mw	93	4	performed	perform	VBN
cord-007084-4niom5mw	93	5	at	at	IN
cord-007084-4niom5mw	93	6	37	37	CD
cord-007084-4niom5mw	93	7	C	c	NN
cord-007084-4niom5mw	93	8	for	for	IN
cord-007084-4niom5mw	93	9	15	15	CD
cord-007084-4niom5mw	93	10	-	-	SYM
cord-007084-4niom5mw	93	11	20	20	CD
cord-007084-4niom5mw	93	12	min	min	NN
cord-007084-4niom5mw	93	13	.	.	.
cord-007084-4niom5mw	94	1	The	the	DT
cord-007084-4niom5mw	94	2	:	:	:
cord-007084-4niom5mw	94	3	incubation	incubation	NN
cord-007084-4niom5mw	94	4	medium	medium	NN
cord-007084-4niom5mw	94	5	in	in	IN
cord-007084-4niom5mw	94	6	a	a	DT
cord-007084-4niom5mw	94	7	final	final	JJ
cord-007084-4niom5mw	94	8	volume	volume	NN
cord-007084-4niom5mw	94	9	of	of	IN
cord-007084-4niom5mw	94	10	0.4	0.4	CD
cord-007084-4niom5mw	94	11	ml	ml	NNS
cord-007084-4niom5mw	94	12	contained	contain	VBD
cord-007084-4niom5mw	94	13	50	50	CD
cord-007084-4niom5mw	94	14	mM	mM	NNP
cord-007084-4niom5mw	94	15	Tris	Tris	NNP
cord-007084-4niom5mw	94	16	-	-	HYPH
cord-007084-4niom5mw	94	17	HCl	HCl	NNP
cord-007084-4niom5mw	94	18	(	(	-LRB-
cord-007084-4niom5mw	94	19	pH	pH	NNP
cord-007084-4niom5mw	94	20	7.4	7.4	CD
cord-007084-4niom5mw	94	21	)	)	-RRB-
cord-007084-4niom5mw	94	22	,	,	,
cord-007084-4niom5mw	94	23	0.6	0.6	CD
cord-007084-4niom5mw	94	24	mM	mm	CD
cord-007084-4niom5mw	94	25	NADPH	NADPH	NNP
cord-007084-4niom5mw	94	26	,	,	,
cord-007084-4niom5mw	94	27	10	10	CD
cord-007084-4niom5mw	94	28	mM	mm	CD
cord-007084-4niom5mw	94	29	glucose-6-phosphate	glucose-6-phosphate	NNP
cord-007084-4niom5mw	94	30	,	,	,
cord-007084-4niom5mw	94	31	1	1	CD
cord-007084-4niom5mw	94	32	U	u	NN
cord-007084-4niom5mw	94	33	/	/	SYM
cord-007084-4niom5mw	94	34	ml	ml	NN
cord-007084-4niom5mw	94	35	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-007084-4niom5mw	94	36	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	94	37	,	,	,
cord-007084-4niom5mw	94	38	5	5	CD
cord-007084-4niom5mw	94	39	mM	mm	CD
cord-007084-4niom5mw	94	40	MgCl	MgCl	NNP
cord-007084-4niom5mw	94	41	2	2	CD
cord-007084-4niom5mw	94	42	,	,	,
cord-007084-4niom5mw	94	43	1	1	CD
cord-007084-4niom5mw	94	44	mM	mm	CD
cord-007084-4niom5mw	94	45	[	[	-LRB-
cord-007084-4niom5mw	94	46	14	14	CD
cord-007084-4niom5mw	94	47	C]progesterone	C]progesterone	NNP
cord-007084-4niom5mw	94	48	(	(	-LRB-
cord-007084-4niom5mw	94	49	10,000	10,000	CD
cord-007084-4niom5mw	94	50	dpm	dpm	NNP
cord-007084-4niom5mw	94	51	/	/	SYM
cord-007084-4niom5mw	94	52	nmol	nmol	NN
cord-007084-4niom5mw	94	53	in	in	IN
cord-007084-4niom5mw	94	54	2.5	2.5	CD
cord-007084-4niom5mw	94	55	%	%	NN
cord-007084-4niom5mw	94	56	propylene	propylene	NN
cord-007084-4niom5mw	94	57	glycol	glycol	NN
cord-007084-4niom5mw	94	58	)	)	-RRB-
cord-007084-4niom5mw	94	59	,	,	,
cord-007084-4niom5mw	94	60	and	and	CC
cord-007084-4niom5mw	94	61	a	a	DT
cord-007084-4niom5mw	94	62	suitable	suitable	JJ
cord-007084-4niom5mw	94	63	aliquot	aliquot	NN
cord-007084-4niom5mw	94	64	of	of	IN
cord-007084-4niom5mw	94	65	the	the	DT
cord-007084-4niom5mw	94	66	micro	micro	JJ
cord-007084-4niom5mw	94	67	-	-	JJ
cord-007084-4niom5mw	94	68	somal	somal	JJ
cord-007084-4niom5mw	94	69	fraction	fraction	NN
cord-007084-4niom5mw	94	70	.	.	.
cord-007084-4niom5mw	95	1	The	the	DT
cord-007084-4niom5mw	95	2	reaction	reaction	NN
cord-007084-4niom5mw	95	3	was	be	VBD
cord-007084-4niom5mw	95	4	initiated	initiate	VBN
cord-007084-4niom5mw	95	5	by	by	IN
cord-007084-4niom5mw	95	6	the	the	DT
cord-007084-4niom5mw	95	7	addition	addition	NN
cord-007084-4niom5mw	95	8	of	of	IN
cord-007084-4niom5mw	95	9	microsomal	microsomal	NNP
cord-007084-4niom5mw	95	10	fraction	fraction	NNP
cord-007084-4niom5mw	95	11	and	and	CC
cord-007084-4niom5mw	95	12	stopped	stop	VBD
cord-007084-4niom5mw	95	13	by	by	IN
cord-007084-4niom5mw	95	14	the	the	DT
cord-007084-4niom5mw	95	15	addition	addition	NN
cord-007084-4niom5mw	95	16	of	of	IN
cord-007084-4niom5mw	95	17	0.04	0.04	CD
cord-007084-4niom5mw	95	18	ml	ml	NN
cord-007084-4niom5mw	95	19	1	1	CD
cord-007084-4niom5mw	95	20	N	n	CD
cord-007084-4niom5mw	95	21	NaOH	NaOH	NNP
cord-007084-4niom5mw	95	22	.	.	.
cord-007084-4niom5mw	96	1	Fifty	fifty	CD
cord-007084-4niom5mw	96	2	micrograms	microgram	NNS
cord-007084-4niom5mw	96	3	each	each	DT
cord-007084-4niom5mw	96	4	of	of	IN
cord-007084-4niom5mw	96	5	progesterone	progesterone	NN
cord-007084-4niom5mw	96	6	and	and	CC
cord-007084-4niom5mw	96	7	deoxycorticosterone	deoxycorticosterone	NNP
cord-007084-4niom5mw	97	1	(	(	-LRB-
cord-007084-4niom5mw	97	2	containing	contain	VBG
cord-007084-4niom5mw	97	3	5000	5000	CD
cord-007084-4niom5mw	97	4	dpm	dpm	NNP
cord-007084-4niom5mw	97	5	[	[	-LRB-
cord-007084-4niom5mw	97	6	3	3	CD
cord-007084-4niom5mw	97	7	H]deoxycorticosterone	H]deoxycorticosterone	NNP
cord-007084-4niom5mw	97	8	to	to	TO
cord-007084-4niom5mw	97	9	monitor	monitor	VB
cord-007084-4niom5mw	97	10	recovery	recovery	NN
cord-007084-4niom5mw	97	11	)	)	-RRB-
cord-007084-4niom5mw	97	12	were	be	VBD
cord-007084-4niom5mw	97	13	added	add	VBN
cord-007084-4niom5mw	97	14	to	to	IN
cord-007084-4niom5mw	97	15	each	each	DT
cord-007084-4niom5mw	97	16	tube	tube	NN
cord-007084-4niom5mw	97	17	,	,	,
cord-007084-4niom5mw	97	18	and	and	CC
cord-007084-4niom5mw	97	19	steroids	steroid	NNS
cord-007084-4niom5mw	97	20	were	be	VBD
cord-007084-4niom5mw	97	21	extracted	extract	VBN
cord-007084-4niom5mw	97	22	with	with	IN
cord-007084-4niom5mw	97	23	dichloromethane	dichloromethane	NNP
cord-007084-4niom5mw	97	24	.	.	.
cord-007084-4niom5mw	98	1	Steroids	steroid	NNS
cord-007084-4niom5mw	98	2	were	be	VBD
cord-007084-4niom5mw	98	3	separated	separate	VBN
cord-007084-4niom5mw	98	4	by	by	IN
cord-007084-4niom5mw	98	5	TLC	TLC	NNP
cord-007084-4niom5mw	98	6	(	(	-LRB-
cord-007084-4niom5mw	98	7	Silica	silica	NN
cord-007084-4niom5mw	98	8	gel	gel	NN
cord-007084-4niom5mw	98	9	F254	f254	CD
cord-007084-4niom5mw	98	10	plates	plate	NNS
cord-007084-4niom5mw	98	11	)	)	-RRB-
cord-007084-4niom5mw	98	12	using	use	VBG
cord-007084-4niom5mw	98	13	dichloromethanebutyl	dichloromethanebutyl	NNP
cord-007084-4niom5mw	98	14	alcohol	alcohol	NNP
cord-007084-4niom5mw	98	15	(	(	-LRB-
cord-007084-4niom5mw	98	16	1:1	1:1	CD
cord-007084-4niom5mw	98	17	,	,	,
cord-007084-4niom5mw	98	18	vol	vol	NNP
cord-007084-4niom5mw	98	19	/	/	SYM
cord-007084-4niom5mw	98	20	vol	vol	NN
cord-007084-4niom5mw	98	21	)	)	-RRB-
cord-007084-4niom5mw	98	22	as	as	IN
cord-007084-4niom5mw	98	23	a	a	DT
cord-007084-4niom5mw	98	24	mobile	mobile	JJ
cord-007084-4niom5mw	98	25	phase	phase	NN
cord-007084-4niom5mw	98	26	.	.	.
cord-007084-4niom5mw	99	1	The	the	DT
cord-007084-4niom5mw	99	2	radioactivity	radioactivity	NN
cord-007084-4niom5mw	99	3	associated	associate	VBN
cord-007084-4niom5mw	99	4	with	with	IN
cord-007084-4niom5mw	99	5	deoxycorticosterone	deoxycorticosterone	NNP
cord-007084-4niom5mw	99	6	was	be	VBD
cord-007084-4niom5mw	99	7	measured	measure	VBN
cord-007084-4niom5mw	99	8	by	by	IN
cord-007084-4niom5mw	99	9	liquid	liquid	JJ
cord-007084-4niom5mw	99	10	scintillation	scintillation	NN
cord-007084-4niom5mw	99	11	spectrometry	spectrometry	NN
cord-007084-4niom5mw	99	12	,	,	,
cord-007084-4niom5mw	99	13	as	as	IN
cord-007084-4niom5mw	99	14	described	describe	VBN
cord-007084-4niom5mw	99	15	above	above	RB
cord-007084-4niom5mw	99	16	.	.	.
cord-007084-4niom5mw	100	1	All	all	DT
cord-007084-4niom5mw	100	2	assays	assay	NNS
cord-007084-4niom5mw	100	3	were	be	VBD
cord-007084-4niom5mw	100	4	carried	carry	VBN
cord-007084-4niom5mw	100	5	out	out	RP
cord-007084-4niom5mw	100	6	in	in	IN
cord-007084-4niom5mw	100	7	triplicate	triplicate	NN
cord-007084-4niom5mw	100	8	.	.	.
cord-007084-4niom5mw	101	1	The	the	DT
cord-007084-4niom5mw	101	2	enzyme	enzyme	NN
cord-007084-4niom5mw	101	3	activity	activity	NN
cord-007084-4niom5mw	101	4	is	be	VBZ
cord-007084-4niom5mw	101	5	expressed	express	VBN
cord-007084-4niom5mw	101	6	as	as	IN
cord-007084-4niom5mw	101	7	nanomoles	nanomole	NNS
cord-007084-4niom5mw	101	8	of	of	IN
cord-007084-4niom5mw	101	9	deoxycorticosterone	deoxycorticosterone	NNP
cord-007084-4niom5mw	101	10	formed	form	VBN
cord-007084-4niom5mw	101	11	per	per	IN
cord-007084-4niom5mw	101	12	min	min	NNP
cord-007084-4niom5mw	101	13	mg	mg	NNP
cord-007084-4niom5mw	101	14	protein	protein	NN
cord-007084-4niom5mw	101	15	"	"	''
cord-007084-4niom5mw	101	16	1	1	CD
cord-007084-4niom5mw	101	17	.	.	.
cord-007084-4niom5mw	102	1	Assay	assay	NN
cord-007084-4niom5mw	102	2	for	for	IN
cord-007084-4niom5mw	102	3	llfi	llfi	NN
cord-007084-4niom5mw	102	4	-	-	HYPH
cord-007084-4niom5mw	102	5	hydroxylase	hydroxylase	NN
cord-007084-4niom5mw	102	6	.	.	.
cord-007084-4niom5mw	103	1	The	the	DT
cord-007084-4niom5mw	103	2	enzyme	enzyme	NN
cord-007084-4niom5mw	103	3	activity	activity	NN
cord-007084-4niom5mw	103	4	was	be	VBD
cord-007084-4niom5mw	103	5	measured	measure	VBN
cord-007084-4niom5mw	103	6	by	by	IN
cord-007084-4niom5mw	103	7	following	follow	VBG
cord-007084-4niom5mw	103	8	the	the	DT
cord-007084-4niom5mw	103	9	conversion	conversion	NN
cord-007084-4niom5mw	103	10	of	of	IN
cord-007084-4niom5mw	103	11	[	[	-LRB-
cord-007084-4niom5mw	103	12	3	3	CD
cord-007084-4niom5mw	103	13	H]deoxycorticosterone	H]deoxycorticosterone	NNP
cord-007084-4niom5mw	103	14	to	to	IN
cord-007084-4niom5mw	103	15	[	[	-LRB-
cord-007084-4niom5mw	103	16	3	3	CD
cord-007084-4niom5mw	103	17	H	h	NN
cord-007084-4niom5mw	103	18	]	]	-RRB-
cord-007084-4niom5mw	103	19	corticosterone	corticosterone	NN
cord-007084-4niom5mw	103	20	,	,	,
cord-007084-4niom5mw	103	21	as	as	IN
cord-007084-4niom5mw	103	22	described	describe	VBN
cord-007084-4niom5mw	103	23	by	by	IN
cord-007084-4niom5mw	103	24	Churchill	Churchill	NNP
cord-007084-4niom5mw	103	25	et	et	NNP
cord-007084-4niom5mw	103	26	al	al	NNP
cord-007084-4niom5mw	103	27	.	.	.
cord-007084-4niom5mw	104	1	(	(	-LRB-
cord-007084-4niom5mw	104	2	22	22	CD
cord-007084-4niom5mw	104	3	)	)	-RRB-
cord-007084-4niom5mw	104	4	.	.	.
cord-007084-4niom5mw	105	1	Briefly	briefly	RB
cord-007084-4niom5mw	105	2	,	,	,
cord-007084-4niom5mw	105	3	incubation	incubation	NN
cord-007084-4niom5mw	105	4	medium	medium	NN
cord-007084-4niom5mw	105	5	in	in	IN
cord-007084-4niom5mw	105	6	a	a	DT
cord-007084-4niom5mw	105	7	final	final	JJ
cord-007084-4niom5mw	105	8	volume	volume	NN
cord-007084-4niom5mw	105	9	of	of	IN
cord-007084-4niom5mw	105	10	0.5	0.5	CD
cord-007084-4niom5mw	105	11	ml	ml	NNS
cord-007084-4niom5mw	105	12	contained	contain	VBD
cord-007084-4niom5mw	105	13	50	50	CD
cord-007084-4niom5mw	105	14	mM	mM	NNP
cord-007084-4niom5mw	105	15	Tris	Tris	NNP
cord-007084-4niom5mw	105	16	-	-	HYPH
cord-007084-4niom5mw	105	17	HCl	HCl	NNP
cord-007084-4niom5mw	105	18	(	(	-LRB-
cord-007084-4niom5mw	105	19	pH	pH	NNP
cord-007084-4niom5mw	105	20	7.4	7.4	CD
cord-007084-4niom5mw	105	21	)	)	-RRB-
cord-007084-4niom5mw	105	22	,	,	,
cord-007084-4niom5mw	105	23	1	1	CD
cord-007084-4niom5mw	105	24	mM	mm	CD
cord-007084-4niom5mw	105	25	MgCl	MgCl	NNP
cord-007084-4niom5mw	105	26	2	2	CD
cord-007084-4niom5mw	105	27	,	,	,
cord-007084-4niom5mw	105	28	1	1	CD
cord-007084-4niom5mw	105	29	mM	mm	CD
cord-007084-4niom5mw	106	1	[	[	-LRB-
cord-007084-4niom5mw	106	2	3	3	CD
cord-007084-4niom5mw	106	3	H]deoxycorticosterone	H]deoxycorticosterone	NNP
cord-007084-4niom5mw	106	4	(	(	-LRB-
cord-007084-4niom5mw	106	5	20,000	20,000	CD
cord-007084-4niom5mw	106	6	dpm	dpm	NNP
cord-007084-4niom5mw	106	7	/	/	SYM
cord-007084-4niom5mw	106	8	nmol	nmol	NN
cord-007084-4niom5mw	106	9	in	in	IN
cord-007084-4niom5mw	106	10	2.5	2.5	CD
cord-007084-4niom5mw	106	11	%	%	NN
cord-007084-4niom5mw	106	12	propylene	propylene	NN
cord-007084-4niom5mw	106	13	glycol	glycol	NN
cord-007084-4niom5mw	106	14	)	)	-RRB-
cord-007084-4niom5mw	106	15	,	,	,
cord-007084-4niom5mw	106	16	0.25	0.25	CD
cord-007084-4niom5mw	106	17	M	M	NNP
cord-007084-4niom5mw	106	18	sucrose	sucrose	NN
cord-007084-4niom5mw	106	19	,	,	,
cord-007084-4niom5mw	106	20	4	4	CD
cord-007084-4niom5mw	106	21	mM	mm	CD
cord-007084-4niom5mw	106	22	sodium	sodium	NN
cord-007084-4niom5mw	106	23	succinate	succinate	NN
cord-007084-4niom5mw	106	24	,	,	,
cord-007084-4niom5mw	106	25	and	and	CC
cord-007084-4niom5mw	106	26	a	a	DT
cord-007084-4niom5mw	106	27	suitable	suitable	JJ
cord-007084-4niom5mw	106	28	aliquot	aliquot	NN
cord-007084-4niom5mw	106	29	of	of	IN
cord-007084-4niom5mw	106	30	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	106	31	preparation	preparation	NN
cord-007084-4niom5mw	106	32	.	.	.
cord-007084-4niom5mw	107	1	All	all	DT
cord-007084-4niom5mw	107	2	incubations	incubation	NNS
cord-007084-4niom5mw	107	3	were	be	VBD
cord-007084-4niom5mw	107	4	carried	carry	VBN
cord-007084-4niom5mw	107	5	out	out	RP
cord-007084-4niom5mw	107	6	at	at	IN
cord-007084-4niom5mw	107	7	37	37	CD
cord-007084-4niom5mw	107	8	C	c	NN
cord-007084-4niom5mw	107	9	for	for	IN
cord-007084-4niom5mw	107	10	15	15	CD
cord-007084-4niom5mw	107	11	-	-	SYM
cord-007084-4niom5mw	107	12	20	20	CD
cord-007084-4niom5mw	107	13	min	min	NN
cord-007084-4niom5mw	107	14	.	.	.
cord-007084-4niom5mw	108	1	The	the	DT
cord-007084-4niom5mw	108	2	reaction	reaction	NN
cord-007084-4niom5mw	108	3	was	be	VBD
cord-007084-4niom5mw	108	4	initiated	initiate	VBN
cord-007084-4niom5mw	108	5	by	by	IN
cord-007084-4niom5mw	108	6	the	the	DT
cord-007084-4niom5mw	108	7	addition	addition	NN
cord-007084-4niom5mw	108	8	of	of	IN
cord-007084-4niom5mw	108	9	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	108	10	suspension	suspension	NN
cord-007084-4niom5mw	108	11	and	and	CC
cord-007084-4niom5mw	108	12	terminated	terminate	VBN
cord-007084-4niom5mw	108	13	by	by	IN
cord-007084-4niom5mw	108	14	the	the	DT
cord-007084-4niom5mw	108	15	addition	addition	NN
cord-007084-4niom5mw	108	16	of	of	IN
cord-007084-4niom5mw	108	17	0.05	0.05	CD
cord-007084-4niom5mw	108	18	ml	ml	NN
cord-007084-4niom5mw	108	19	1	1	CD
cord-007084-4niom5mw	108	20	N	n	CD
cord-007084-4niom5mw	108	21	NaOH	NaOH	NNP
cord-007084-4niom5mw	108	22	.	.	.
cord-007084-4niom5mw	109	1	Fifty	fifty	CD
cord-007084-4niom5mw	109	2	micrograms	microgram	NNS
cord-007084-4niom5mw	109	3	each	each	DT
cord-007084-4niom5mw	109	4	of	of	IN
cord-007084-4niom5mw	109	5	deoxycorticosterone	deoxycorticosterone	NN
cord-007084-4niom5mw	109	6	and	and	CC
cord-007084-4niom5mw	109	7	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	109	8	were	be	VBD
cord-007084-4niom5mw	109	9	added	add	VBN
cord-007084-4niom5mw	109	10	to	to	IN
cord-007084-4niom5mw	109	11	each	each	DT
cord-007084-4niom5mw	109	12	tube	tube	NN
cord-007084-4niom5mw	109	13	,	,	,
cord-007084-4niom5mw	109	14	and	and	CC
cord-007084-4niom5mw	109	15	steroids	steroid	NNS
cord-007084-4niom5mw	109	16	were	be	VBD
cord-007084-4niom5mw	109	17	extracted	extract	VBN
cord-007084-4niom5mw	109	18	with	with	IN
cord-007084-4niom5mw	109	19	dichloromethane	dichloromethane	NNP
cord-007084-4niom5mw	109	20	.	.	.
cord-007084-4niom5mw	110	1	Steroid	steroid	NN
cord-007084-4niom5mw	110	2	were	be	VBD
cord-007084-4niom5mw	110	3	separated	separate	VBN
cord-007084-4niom5mw	110	4	by	by	IN
cord-007084-4niom5mw	110	5	TLC	TLC	NNP
cord-007084-4niom5mw	110	6	using	use	VBG
cord-007084-4niom5mw	110	7	silica	silica	NN
cord-007084-4niom5mw	110	8	gel	gel	NN
cord-007084-4niom5mw	110	9	F	F	NNP
cord-007084-4niom5mw	110	10	254	254	CD
cord-007084-4niom5mw	110	11	plates	plate	NNS
cord-007084-4niom5mw	110	12	and	and	CC
cord-007084-4niom5mw	110	13	dichloromethane	dichloromethane	NN
cord-007084-4niom5mw	110	14	-	-	HYPH
cord-007084-4niom5mw	110	15	butyl	butyl	NN
cord-007084-4niom5mw	110	16	alcohol	alcohol	NN
cord-007084-4niom5mw	110	17	(	(	-LRB-
cord-007084-4niom5mw	110	18	1:1	1:1	CD
cord-007084-4niom5mw	110	19	,	,	,
cord-007084-4niom5mw	110	20	vol	vol	NNP
cord-007084-4niom5mw	110	21	/	/	SYM
cord-007084-4niom5mw	110	22	vol	vol	NN
cord-007084-4niom5mw	110	23	)	)	-RRB-
cord-007084-4niom5mw	110	24	as	as	IN
cord-007084-4niom5mw	110	25	a	a	DT
cord-007084-4niom5mw	110	26	solvent	solvent	NN
cord-007084-4niom5mw	110	27	system	system	NN
cord-007084-4niom5mw	110	28	.	.	.
cord-007084-4niom5mw	111	1	The	the	DT
cord-007084-4niom5mw	111	2	plates	plate	NNS
cord-007084-4niom5mw	111	3	were	be	VBD
cord-007084-4niom5mw	111	4	run	run	VBN
cord-007084-4niom5mw	111	5	three	three	CD
cord-007084-4niom5mw	111	6	times	time	NNS
cord-007084-4niom5mw	111	7	in	in	IN
cord-007084-4niom5mw	111	8	same	same	JJ
cord-007084-4niom5mw	111	9	solvent	solvent	NN
cord-007084-4niom5mw	111	10	system	system	NN
cord-007084-4niom5mw	111	11	,	,	,
cord-007084-4niom5mw	111	12	and	and	CC
cord-007084-4niom5mw	111	13	the	the	DT
cord-007084-4niom5mw	111	14	corticosteronecontaining	corticosteronecontaine	VBG
cord-007084-4niom5mw	111	15	areas	area	NNS
cord-007084-4niom5mw	111	16	were	be	VBD
cord-007084-4niom5mw	111	17	isolated	isolate	VBN
cord-007084-4niom5mw	111	18	,	,	,
cord-007084-4niom5mw	111	19	eluted	eluted	JJ
cord-007084-4niom5mw	111	20	,	,	,
cord-007084-4niom5mw	111	21	and	and	CC
cord-007084-4niom5mw	111	22	counted	count	VBN
cord-007084-4niom5mw	111	23	for	for	IN
cord-007084-4niom5mw	111	24	radioactivity	radioactivity	NN
cord-007084-4niom5mw	111	25	by	by	IN
cord-007084-4niom5mw	111	26	liquid	liquid	JJ
cord-007084-4niom5mw	111	27	scintillation	scintillation	NN
cord-007084-4niom5mw	111	28	spectrometry	spectrometry	NN
cord-007084-4niom5mw	111	29	,	,	,
cord-007084-4niom5mw	111	30	as	as	IN
cord-007084-4niom5mw	111	31	described	describe	VBN
cord-007084-4niom5mw	111	32	above	above	RB
cord-007084-4niom5mw	111	33	.	.	.
cord-007084-4niom5mw	112	1	All	all	DT
cord-007084-4niom5mw	112	2	enzyme	enzyme	NN
cord-007084-4niom5mw	112	3	assays	assay	NNS
cord-007084-4niom5mw	112	4	were	be	VBD
cord-007084-4niom5mw	112	5	carried	carry	VBN
cord-007084-4niom5mw	112	6	out	out	RP
cord-007084-4niom5mw	112	7	in	in	IN
cord-007084-4niom5mw	112	8	triplicate	triplicate	NN
cord-007084-4niom5mw	112	9	.	.	.
cord-007084-4niom5mw	113	1	The	the	DT
cord-007084-4niom5mw	113	2	enzyme	enzyme	NN
cord-007084-4niom5mw	113	3	activity	activity	NN
cord-007084-4niom5mw	113	4	is	be	VBZ
cord-007084-4niom5mw	113	5	expressed	express	VBN
cord-007084-4niom5mw	113	6	as	as	IN
cord-007084-4niom5mw	113	7	nanomoles	nanomole	NNS
cord-007084-4niom5mw	113	8	of	of	IN
cord-007084-4niom5mw	113	9	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	113	10	formed	form	VBN
cord-007084-4niom5mw	113	11	per	per	IN
cord-007084-4niom5mw	113	12	min	min	NNP
cord-007084-4niom5mw	113	13	mg	mg	NNP
cord-007084-4niom5mw	113	14	protein	protein	NN
cord-007084-4niom5mw	113	15	"	"	''
cord-007084-4niom5mw	113	16	1	1	CD
cord-007084-4niom5mw	113	17	.	.	.
cord-007084-4niom5mw	114	1	Measurement	measurement	NN
cord-007084-4niom5mw	114	2	of	of	IN
cord-007084-4niom5mw	114	3	cytochrome	cytochrome	NN
cord-007084-4niom5mw	114	4	P-450	p-450	NN
cord-007084-4niom5mw	114	5	.	.	.
cord-007084-4niom5mw	115	1	Mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	115	2	cytochrome	cytochrome	NN
cord-007084-4niom5mw	115	3	P-450	p-450	NN
cord-007084-4niom5mw	115	4	was	be	VBD
cord-007084-4niom5mw	115	5	measured	measure	VBN
cord-007084-4niom5mw	115	6	according	accord	VBG
cord-007084-4niom5mw	115	7	to	to	IN
cord-007084-4niom5mw	115	8	the	the	DT
cord-007084-4niom5mw	115	9	method	method	NN
cord-007084-4niom5mw	115	10	of	of	IN
cord-007084-4niom5mw	115	11	Omura	Omura	NNP
cord-007084-4niom5mw	115	12	and	and	CC
cord-007084-4niom5mw	115	13	Sato	Sato	NNP
cord-007084-4niom5mw	115	14	(	(	-LRB-
cord-007084-4niom5mw	115	15	23	23	CD
cord-007084-4niom5mw	115	16	)	)	-RRB-
cord-007084-4niom5mw	115	17	.	.	.
cord-007084-4niom5mw	116	1	The	the	DT
cord-007084-4niom5mw	116	2	extinction	extinction	NN
cord-007084-4niom5mw	116	3	coefficient	coefficient	NN
cord-007084-4niom5mw	116	4	of	of	IN
cord-007084-4niom5mw	116	5	91	91	CD
cord-007084-4niom5mw	116	6	cm	cm	NNS
cord-007084-4niom5mw	116	7	"	"	``
cord-007084-4niom5mw	116	8	1	1	CD
cord-007084-4niom5mw	116	9	mM	mm	CD
cord-007084-4niom5mw	116	10	"	"	''
cord-007084-4niom5mw	116	11	1	1	CD
cord-007084-4niom5mw	116	12	was	be	VBD
cord-007084-4niom5mw	116	13	used	use	VBN
cord-007084-4niom5mw	116	14	to	to	TO
cord-007084-4niom5mw	116	15	calculate	calculate	VB
cord-007084-4niom5mw	116	16	the	the	DT
cord-007084-4niom5mw	116	17	cytochrome	cytochrome	NN
cord-007084-4niom5mw	116	18	P-450	P-450	VBD
cord-007084-4niom5mw	116	19	concentration	concentration	NN
cord-007084-4niom5mw	116	20	from	from	IN
cord-007084-4niom5mw	116	21	the	the	DT
cord-007084-4niom5mw	116	22	absorbancy	absorbancy	NN
cord-007084-4niom5mw	116	23	difference	difference	NN
cord-007084-4niom5mw	116	24	between	between	IN
cord-007084-4niom5mw	116	25	450	450	CD
cord-007084-4niom5mw	116	26	and	and	CC
cord-007084-4niom5mw	116	27	490	490	CD
cord-007084-4niom5mw	116	28	nm	nm	NN
cord-007084-4niom5mw	116	29	.	.	.
cord-007084-4niom5mw	117	1	Miscellaneous	miscellaneous	JJ
cord-007084-4niom5mw	117	2	enzyme	enzyme	NN
cord-007084-4niom5mw	117	3	assays	assay	NNS
cord-007084-4niom5mw	117	4	.	.	.
cord-007084-4niom5mw	118	1	Succinate	succinate	NN
cord-007084-4niom5mw	118	2	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	118	3	activity	activity	NN
cord-007084-4niom5mw	118	4	was	be	VBD
cord-007084-4niom5mw	118	5	measured	measure	VBN
cord-007084-4niom5mw	118	6	according	accord	VBG
cord-007084-4niom5mw	118	7	to	to	IN
cord-007084-4niom5mw	118	8	the	the	DT
cord-007084-4niom5mw	118	9	method	method	NN
cord-007084-4niom5mw	118	10	of	of	IN
cord-007084-4niom5mw	118	11	Pennington	Pennington	NNP
cord-007084-4niom5mw	118	12	(	(	-LRB-
cord-007084-4niom5mw	118	13	24	24	CD
cord-007084-4niom5mw	118	14	)	)	-RRB-
cord-007084-4niom5mw	118	15	.	.	.
cord-007084-4niom5mw	119	1	The	the	DT
cord-007084-4niom5mw	119	2	activity	activity	NN
cord-007084-4niom5mw	119	3	is	be	VBZ
cord-007084-4niom5mw	119	4	expressed	express	VBN
cord-007084-4niom5mw	119	5	as	as	IN
cord-007084-4niom5mw	119	6	nanomoles	nanomole	NNS
cord-007084-4niom5mw	119	7	of	of	IN
cord-007084-4niom5mw	119	8	2-(p	2-(p	CD
cord-007084-4niom5mw	119	9	-	-	HYPH
cord-007084-4niom5mw	119	10	iodophenyl)3-(pnitrophenyl)5-phenyltetrazolium	iodophenyl)3-(pnitrophenyl)5-phenyltetrazolium	NN
cord-007084-4niom5mw	119	11	reduced	reduce	VBN
cord-007084-4niom5mw	119	12	per	per	IN
cord-007084-4niom5mw	119	13	min	min	NN
cord-007084-4niom5mw	119	14	mg	mg	NNP
cord-007084-4niom5mw	119	15	protein	protein	NN
cord-007084-4niom5mw	119	16	"	"	''
cord-007084-4niom5mw	119	17	1	1	CD
cord-007084-4niom5mw	119	18	.	.	.
cord-007084-4niom5mw	120	1	Malate	Malate	NNP
cord-007084-4niom5mw	120	2	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	120	3	was	be	VBD
cord-007084-4niom5mw	120	4	assayed	assay	VBN
cord-007084-4niom5mw	120	5	by	by	IN
cord-007084-4niom5mw	120	6	a	a	DT
cord-007084-4niom5mw	120	7	modification	modification	NN
cord-007084-4niom5mw	120	8	of	of	IN
cord-007084-4niom5mw	120	9	the	the	DT
cord-007084-4niom5mw	120	10	procedure	procedure	NN
cord-007084-4niom5mw	120	11	of	of	IN
cord-007084-4niom5mw	120	12	Ochoa	Ochoa	NNP
cord-007084-4niom5mw	120	13	(	(	-LRB-
cord-007084-4niom5mw	120	14	25	25	CD
cord-007084-4niom5mw	120	15	)	)	-RRB-
cord-007084-4niom5mw	120	16	,	,	,
cord-007084-4niom5mw	120	17	as	as	IN
cord-007084-4niom5mw	120	18	described	describe	VBN
cord-007084-4niom5mw	120	19	by	by	IN
cord-007084-4niom5mw	120	20	Vardanis	Vardanis	NNP
cord-007084-4niom5mw	120	21	(	(	-LRB-
cord-007084-4niom5mw	120	22	26	26	CD
cord-007084-4niom5mw	120	23	)	)	-RRB-
cord-007084-4niom5mw	120	24	,	,	,
cord-007084-4niom5mw	120	25	with	with	IN
cord-007084-4niom5mw	120	26	activity	activity	NN
cord-007084-4niom5mw	120	27	expressed	express	VBN
cord-007084-4niom5mw	120	28	as	as	IN
cord-007084-4niom5mw	120	29	nanomoles	nanomole	NNS
cord-007084-4niom5mw	120	30	of	of	IN
cord-007084-4niom5mw	120	31	NADH	NADH	NNP
cord-007084-4niom5mw	120	32	oxidized	oxidize	VBN
cord-007084-4niom5mw	120	33	per	per	IN
cord-007084-4niom5mw	120	34	min	min	NN
cord-007084-4niom5mw	120	35	mg	mg	NNP
cord-007084-4niom5mw	120	36	protein	protein	NN
cord-007084-4niom5mw	120	37	"	"	''
cord-007084-4niom5mw	120	38	1	1	CD
cord-007084-4niom5mw	120	39	.	.	.
cord-007084-4niom5mw	121	1	The	the	DT
cord-007084-4niom5mw	121	2	radiochemical	radiochemical	JJ
cord-007084-4niom5mw	121	3	procedure	procedure	NN
cord-007084-4niom5mw	121	4	of	of	IN
cord-007084-4niom5mw	121	5	McCaman	McCaman	NNP
cord-007084-4niom5mw	121	6	et	et	NNP
cord-007084-4niom5mw	121	7	al	al	NNP
cord-007084-4niom5mw	121	8	.	.	.
cord-007084-4niom5mw	122	1	(	(	-LRB-
cord-007084-4niom5mw	122	2	27	27	CD
cord-007084-4niom5mw	122	3	)	)	-RRB-
cord-007084-4niom5mw	122	4	was	be	VBD
cord-007084-4niom5mw	122	5	used	use	VBN
cord-007084-4niom5mw	122	6	to	to	TO
cord-007084-4niom5mw	122	7	quantitate	quantitate	VB
cord-007084-4niom5mw	122	8	monoamine	monoamine	NN
cord-007084-4niom5mw	122	9	oxidase	oxidase	NN
cord-007084-4niom5mw	122	10	,	,	,
cord-007084-4niom5mw	122	11	with	with	IN
cord-007084-4niom5mw	122	12	activity	activity	NN
cord-007084-4niom5mw	122	13	expressed	express	VBN
cord-007084-4niom5mw	122	14	as	as	IN
cord-007084-4niom5mw	122	15	nanomoles	nanomole	NNS
cord-007084-4niom5mw	122	16	of	of	IN
cord-007084-4niom5mw	122	17	benzaldehyde	benzaldehyde	NN
cord-007084-4niom5mw	122	18	produced	produce	VBN
cord-007084-4niom5mw	122	19	per	per	IN
cord-007084-4niom5mw	122	20	min	min	NN
cord-007084-4niom5mw	122	21	mg	mg	NNP
cord-007084-4niom5mw	122	22	protein	protein	NN
cord-007084-4niom5mw	122	23	"	"	''
cord-007084-4niom5mw	122	24	1	1	CD
cord-007084-4niom5mw	122	25	.	.	.
cord-007084-4niom5mw	123	1	Amytal	amytal	JJ
cord-007084-4niom5mw	123	2	-	-	HYPH
cord-007084-4niom5mw	123	3	insensitive	insensitive	JJ
cord-007084-4niom5mw	123	4	NADH	NADH	NNP
cord-007084-4niom5mw	123	5	cytochrome	cytochrome	NN
cord-007084-4niom5mw	123	6	c	c	NN
cord-007084-4niom5mw	123	7	reductase	reductase	NN
cord-007084-4niom5mw	123	8	was	be	VBD
cord-007084-4niom5mw	123	9	measured	measure	VBN
cord-007084-4niom5mw	123	10	by	by	IN
cord-007084-4niom5mw	123	11	a	a	DT
cord-007084-4niom5mw	123	12	combination	combination	NN
cord-007084-4niom5mw	123	13	of	of	IN
cord-007084-4niom5mw	123	14	the	the	DT
cord-007084-4niom5mw	123	15	procedures	procedure	NNS
cord-007084-4niom5mw	123	16	of	of	IN
cord-007084-4niom5mw	123	17	Sottocasa	Sottocasa	NNP
cord-007084-4niom5mw	123	18	et	et	FW
cord-007084-4niom5mw	123	19	al	al	NNP
cord-007084-4niom5mw	123	20	.	.	.
cord-007084-4niom5mw	124	1	(	(	-LRB-
cord-007084-4niom5mw	124	2	28	28	CD
cord-007084-4niom5mw	124	3	)	)	-RRB-
cord-007084-4niom5mw	124	4	and	and	CC
cord-007084-4niom5mw	124	5	Privalle	Privalle	NNP
cord-007084-4niom5mw	124	6	et	et	NNP
cord-007084-4niom5mw	124	7	al	al	NNP
cord-007084-4niom5mw	124	8	.	.	.
cord-007084-4niom5mw	125	1	(	(	-LRB-
cord-007084-4niom5mw	125	2	29	29	CD
cord-007084-4niom5mw	125	3	)	)	-RRB-
cord-007084-4niom5mw	125	4	.	.	.
cord-007084-4niom5mw	126	1	The	the	DT
cord-007084-4niom5mw	126	2	enzyme	enzyme	NN
cord-007084-4niom5mw	126	3	activity	activity	NN
cord-007084-4niom5mw	126	4	is	be	VBZ
cord-007084-4niom5mw	126	5	expressed	express	VBN
cord-007084-4niom5mw	126	6	as	as	IN
cord-007084-4niom5mw	126	7	nanomoles	nanomole	NNS
cord-007084-4niom5mw	126	8	of	of	IN
cord-007084-4niom5mw	126	9	cytochrome	cytochrome	NN
cord-007084-4niom5mw	126	10	c	c	NN
cord-007084-4niom5mw	126	11	reduced	reduce	VBN
cord-007084-4niom5mw	126	12	per	per	IN
cord-007084-4niom5mw	126	13	min	min	NNP
cord-007084-4niom5mw	126	14	mg	mg	NNP
cord-007084-4niom5mw	126	15	protein	protein	NN
cord-007084-4niom5mw	126	16	"	"	''
cord-007084-4niom5mw	126	17	1	1	CD
cord-007084-4niom5mw	126	18	.	.	.
cord-007084-4niom5mw	127	1	Cytochrome	cytochrome	NN
cord-007084-4niom5mw	127	2	oxidase	oxidase	NN
cord-007084-4niom5mw	127	3	activity	activity	NN
cord-007084-4niom5mw	127	4	was	be	VBD
cord-007084-4niom5mw	127	5	measured	measure	VBN
cord-007084-4niom5mw	127	6	according	accord	VBG
cord-007084-4niom5mw	127	7	to	to	IN
cord-007084-4niom5mw	127	8	the	the	DT
cord-007084-4niom5mw	127	9	methods	method	NNS
cord-007084-4niom5mw	127	10	of	of	IN
cord-007084-4niom5mw	127	11	Cooperstein	Cooperstein	NNP
cord-007084-4niom5mw	127	12	and	and	CC
cord-007084-4niom5mw	127	13	Lazarow	Lazarow	NNP
cord-007084-4niom5mw	127	14	(	(	-LRB-
cord-007084-4niom5mw	127	15	30	30	CD
cord-007084-4niom5mw	127	16	)	)	-RRB-
cord-007084-4niom5mw	127	17	,	,	,
cord-007084-4niom5mw	127	18	with	with	IN
cord-007084-4niom5mw	127	19	activity	activity	NN
cord-007084-4niom5mw	127	20	expressed	express	VBN
cord-007084-4niom5mw	127	21	as	as	IN
cord-007084-4niom5mw	127	22	nanomoles	nanomole	NNS
cord-007084-4niom5mw	127	23	of	of	IN
cord-007084-4niom5mw	127	24	cytochrome	cytochrome	NN
cord-007084-4niom5mw	127	25	c	c	NN
cord-007084-4niom5mw	127	26	oxidized	oxidize	VBN
cord-007084-4niom5mw	128	1	per	per	IN
cord-007084-4niom5mw	128	2	min	min	NNP
cord-007084-4niom5mw	128	3	mg	mg	NNP
cord-007084-4niom5mw	128	4	protein	protein	NN
cord-007084-4niom5mw	128	5	"	"	''
cord-007084-4niom5mw	128	6	1	1	CD
cord-007084-4niom5mw	128	7	.	.	.
cord-007084-4niom5mw	129	1	The	the	DT
cord-007084-4niom5mw	129	2	protein	protein	NN
cord-007084-4niom5mw	129	3	content	content	NN
cord-007084-4niom5mw	129	4	of	of	IN
cord-007084-4niom5mw	129	5	all	all	DT
cord-007084-4niom5mw	129	6	fractions	fraction	NNS
cord-007084-4niom5mw	129	7	was	be	VBD
cord-007084-4niom5mw	129	8	measured	measure	VBN
cord-007084-4niom5mw	129	9	by	by	IN
cord-007084-4niom5mw	129	10	the	the	DT
cord-007084-4niom5mw	129	11	modified	modify	VBN
cord-007084-4niom5mw	129	12	procedure	procedure	NN
cord-007084-4niom5mw	129	13	of	of	IN
cord-007084-4niom5mw	129	14	Lowry	Lowry	NNP
cord-007084-4niom5mw	129	15	et	et	NNP
cord-007084-4niom5mw	129	16	al	al	NNP
cord-007084-4niom5mw	129	17	.	.	.
cord-007084-4niom5mw	130	1	(	(	-LRB-
cord-007084-4niom5mw	130	2	31	31	CD
cord-007084-4niom5mw	130	3	)	)	-RRB-
cord-007084-4niom5mw	130	4	,	,	,
cord-007084-4niom5mw	130	5	as	as	IN
cord-007084-4niom5mw	130	6	described	describe	VBN
cord-007084-4niom5mw	130	7	by	by	IN
cord-007084-4niom5mw	130	8	Markwell	Markwell	NNP
cord-007084-4niom5mw	130	9	et	et	NNP
cord-007084-4niom5mw	130	10	al	al	NNP
cord-007084-4niom5mw	130	11	.	.	.
cord-007084-4niom5mw	131	1	(	(	-LRB-
cord-007084-4niom5mw	131	2	32	32	CD
cord-007084-4niom5mw	131	3	)	)	-RRB-
cord-007084-4niom5mw	131	4	.	.	.
cord-007084-4niom5mw	132	1	Statistical	statistical	JJ
cord-007084-4niom5mw	132	2	analyses	analysis	NNS
cord-007084-4niom5mw	132	3	.	.	.
cord-007084-4niom5mw	133	1	The	the	DT
cord-007084-4niom5mw	133	2	results	result	NNS
cord-007084-4niom5mw	133	3	are	be	VBP
cord-007084-4niom5mw	133	4	expressed	express	VBN
cord-007084-4niom5mw	133	5	as	as	IN
cord-007084-4niom5mw	133	6	the	the	DT
cord-007084-4niom5mw	133	7	mean	mean	JJ
cord-007084-4niom5mw	133	8	±	±	NNP
cord-007084-4niom5mw	133	9	SE	SE	NNP
cord-007084-4niom5mw	133	10	.	.	.
cord-007084-4niom5mw	134	1	The	the	DT
cord-007084-4niom5mw	134	2	results	result	NNS
cord-007084-4niom5mw	134	3	were	be	VBD
cord-007084-4niom5mw	134	4	analyzed	analyze	VBN
cord-007084-4niom5mw	134	5	by	by	IN
cord-007084-4niom5mw	134	6	analysis	analysis	NN
cord-007084-4niom5mw	134	7	of	of	IN
cord-007084-4niom5mw	134	8	variance	variance	NN
cord-007084-4niom5mw	134	9	.	.	.
cord-007084-4niom5mw	135	1	The	the	DT
cord-007084-4niom5mw	135	2	analysis	analysis	NN
cord-007084-4niom5mw	135	3	used	use	VBD
cord-007084-4niom5mw	135	4	the	the	DT
cord-007084-4niom5mw	135	5	general	general	JJ
cord-007084-4niom5mw	135	6	linear	linear	JJ
cord-007084-4niom5mw	135	7	models	model	NNS
cord-007084-4niom5mw	135	8	procedures	procedure	NNS
cord-007084-4niom5mw	135	9	of	of	IN
cord-007084-4niom5mw	135	10	SAS	SAS	NNP
cord-007084-4niom5mw	135	11	(	(	-LRB-
cord-007084-4niom5mw	135	12	SAS	SAS	NNP
cord-007084-4niom5mw	135	13	Institute	Institute	NNP
cord-007084-4niom5mw	135	14	,	,	,
cord-007084-4niom5mw	135	15	Cary	Cary	NNP
cord-007084-4niom5mw	135	16	,	,	,
cord-007084-4niom5mw	135	17	NC	NC	NNP
cord-007084-4niom5mw	135	18	)	)	-RRB-
cord-007084-4niom5mw	135	19	when	when	WRB
cord-007084-4niom5mw	135	20	giving	give	VBG
cord-007084-4niom5mw	135	21	a	a	DT
cord-007084-4niom5mw	135	22	significant	significant	JJ
cord-007084-4niom5mw	135	23	F	F	NNP
cord-007084-4niom5mw	135	24	value	value	NN
cord-007084-4niom5mw	135	25	;	;	:
cord-007084-4niom5mw	135	26	Scheffe	Scheffe	NNP
cord-007084-4niom5mw	135	27	's	's	POS
cord-007084-4niom5mw	135	28	posttests	posttest	NNS
cord-007084-4niom5mw	135	29	were	be	VBD
cord-007084-4niom5mw	135	30	used	use	VBN
cord-007084-4niom5mw	135	31	to	to	TO
cord-007084-4niom5mw	135	32	determine	determine	VB
cord-007084-4niom5mw	135	33	differences	difference	NNS
cord-007084-4niom5mw	135	34	between	between	IN
cord-007084-4niom5mw	135	35	any	any	DT
cord-007084-4niom5mw	135	36	two	two	CD
cord-007084-4niom5mw	135	37	age	age	NN
cord-007084-4niom5mw	135	38	groups	group	NNS
cord-007084-4niom5mw	135	39	.	.	.
cord-007084-4niom5mw	136	1	P	p	NN
cord-007084-4niom5mw	136	2	<	<	XX
cord-007084-4niom5mw	136	3	0.05	0.05	CD
cord-007084-4niom5mw	136	4	was	be	VBD
cord-007084-4niom5mw	136	5	considered	consider	VBN
cord-007084-4niom5mw	136	6	statistically	statistically	RB
cord-007084-4niom5mw	136	7	significant	significant	JJ
cord-007084-4niom5mw	136	8	.	.	.
cord-007084-4niom5mw	137	1	Cholesterol	cholesterol	NN
cord-007084-4niom5mw	137	2	side	side	NN
cord-007084-4niom5mw	137	3	-	-	HYPH
cord-007084-4niom5mw	137	4	chain	chain	NN
cord-007084-4niom5mw	137	5	cleavage	cleavage	NN
cord-007084-4niom5mw	137	6	enzyme	enzyme	NN
cord-007084-4niom5mw	137	7	activity	activity	NN
cord-007084-4niom5mw	137	8	,	,	,
cord-007084-4niom5mw	137	9	the	the	DT
cord-007084-4niom5mw	137	10	rate	rate	NN
cord-007084-4niom5mw	137	11	-	-	HYPH
cord-007084-4niom5mw	137	12	limiting	limit	VBG
cord-007084-4niom5mw	137	13	enzyme	enzyme	NN
cord-007084-4niom5mw	137	14	in	in	IN
cord-007084-4niom5mw	137	15	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	137	16	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	137	17	,	,	,
cord-007084-4niom5mw	137	18	was	be	VBD
cord-007084-4niom5mw	137	19	measured	measure	VBN
cord-007084-4niom5mw	137	20	in	in	IN
cord-007084-4niom5mw	137	21	adrenal	adrenal	JJ
cord-007084-4niom5mw	137	22	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	137	23	isolated	isolate	VBN
cord-007084-4niom5mw	137	24	from	from	IN
cord-007084-4niom5mw	137	25	2-	2-	CD
cord-007084-4niom5mw	137	26	,	,	,
cord-007084-4niom5mw	137	27	12-	12-	NNP
cord-007084-4niom5mw	137	28	,	,	,
cord-007084-4niom5mw	137	29	and	and	CC
cord-007084-4niom5mw	137	30	18-month	18-month	JJ
cord-007084-4niom5mw	137	31	-	-	HYPH
cord-007084-4niom5mw	137	32	old	old	JJ
cord-007084-4niom5mw	137	33	male	male	JJ
cord-007084-4niom5mw	137	34	Sprague	Sprague	NNP
cord-007084-4niom5mw	137	35	-	-	HYPH
cord-007084-4niom5mw	137	36	Dawley	Dawley	NNP
cord-007084-4niom5mw	137	37	rats	rat	NNS
cord-007084-4niom5mw	137	38	.	.	.
cord-007084-4niom5mw	138	1	All	all	DT
cord-007084-4niom5mw	138	2	assays	assay	NNS
cord-007084-4niom5mw	138	3	were	be	VBD
cord-007084-4niom5mw	138	4	carried	carry	VBN
cord-007084-4niom5mw	138	5	out	out	RP
cord-007084-4niom5mw	138	6	in	in	IN
cord-007084-4niom5mw	138	7	the	the	DT
cord-007084-4niom5mw	138	8	presence	presence	NN
cord-007084-4niom5mw	138	9	and	and	CC
cord-007084-4niom5mw	138	10	absence	absence	NN
cord-007084-4niom5mw	138	11	of	of	IN
cord-007084-4niom5mw	138	12	25hydroxycholesterol	25hydroxycholesterol	CD
cord-007084-4niom5mw	138	13	(	(	-LRB-
cord-007084-4niom5mw	138	14	25	25	CD
cord-007084-4niom5mw	138	15	/ug	/ug	,
cord-007084-4niom5mw	138	16	/	/	SYM
cord-007084-4niom5mw	138	17	ml	ml	NN
cord-007084-4niom5mw	138	18	)	)	-RRB-
cord-007084-4niom5mw	138	19	.	.	.
cord-007084-4niom5mw	139	1	The	the	DT
cord-007084-4niom5mw	139	2	enzyme	enzyme	NN
cord-007084-4niom5mw	139	3	-	-	HYPH
cord-007084-4niom5mw	139	4	catalyzed	catalyze	VBN
cord-007084-4niom5mw	139	5	reaction	reaction	NN
cord-007084-4niom5mw	139	6	product	product	NN
cord-007084-4niom5mw	139	7	,	,	,
cord-007084-4niom5mw	139	8	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	139	9	,	,	,
cord-007084-4niom5mw	139	10	was	be	VBD
cord-007084-4niom5mw	139	11	quantitated	quantitate	VBN
cord-007084-4niom5mw	139	12	by	by	IN
cord-007084-4niom5mw	139	13	a	a	DT
cord-007084-4niom5mw	139	14	specific	specific	JJ
cord-007084-4niom5mw	139	15	RIA	RIA	NNP
cord-007084-4niom5mw	139	16	.	.	.
cord-007084-4niom5mw	140	1	Results	result	NNS
cord-007084-4niom5mw	140	2	presented	present	VBN
cord-007084-4niom5mw	140	3	in	in	IN
cord-007084-4niom5mw	140	4	Figs	Figs	NNP
cord-007084-4niom5mw	140	5	.	.	.
cord-007084-4niom5mw	141	1	1	1	CD
cord-007084-4niom5mw	141	2	and	and	CC
cord-007084-4niom5mw	141	3	2	2	CD
cord-007084-4niom5mw	141	4	show	show	NN
cord-007084-4niom5mw	141	5	incubation	incubation	NN
cord-007084-4niom5mw	141	6	time	time	NN
cord-007084-4niom5mw	141	7	-	-	HYPH
cord-007084-4niom5mw	141	8	and	and	CC
cord-007084-4niom5mw	141	9	enzyme	enzyme	NN
cord-007084-4niom5mw	141	10	concentration	concentration	NN
cord-007084-4niom5mw	141	11	-	-	HYPH
cord-007084-4niom5mw	141	12	dependent	dependent	JJ
cord-007084-4niom5mw	141	13	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	141	14	formation	formation	NN
cord-007084-4niom5mw	141	15	by	by	IN
cord-007084-4niom5mw	141	16	the	the	DT
cord-007084-4niom5mw	141	17	adrenal	adrenal	JJ
cord-007084-4niom5mw	141	18	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	141	19	isolated	isolate	VBN
cord-007084-4niom5mw	141	20	from	from	IN
cord-007084-4niom5mw	141	21	2-and	2-and	CD
cord-007084-4niom5mw	141	22	12-month	12-month	JJ
cord-007084-4niom5mw	141	23	-	-	HYPH
cord-007084-4niom5mw	141	24	old	old	JJ
cord-007084-4niom5mw	141	25	rats	rat	NNS
cord-007084-4niom5mw	141	26	.	.	.
cord-007084-4niom5mw	142	1	Under	under	IN
cord-007084-4niom5mw	142	2	basal	basal	NN
cord-007084-4niom5mw	142	3	conditions	condition	NNS
cord-007084-4niom5mw	142	4	,	,	,
cord-007084-4niom5mw	142	5	the	the	DT
cord-007084-4niom5mw	142	6	rate	rate	NN
cord-007084-4niom5mw	142	7	of	of	IN
cord-007084-4niom5mw	142	8	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	142	9	formation	formation	NN
cord-007084-4niom5mw	142	10	was	be	VBD
cord-007084-4niom5mw	142	11	low	low	JJ
cord-007084-4niom5mw	142	12	and	and	CC
cord-007084-4niom5mw	142	13	exhibited	exhibit	VBD
cord-007084-4niom5mw	142	14	a	a	DT
cord-007084-4niom5mw	142	15	biphasic	biphasic	JJ
cord-007084-4niom5mw	142	16	response	response	NN
cord-007084-4niom5mw	142	17	(	(	-LRB-
cord-007084-4niom5mw	142	18	Fig	Fig	NNP
cord-007084-4niom5mw	142	19	.	.	NNP
cord-007084-4niom5mw	142	20	1	1	CD
cord-007084-4niom5mw	142	21	,	,	,
cord-007084-4niom5mw	142	22	inset	inset	NN
cord-007084-4niom5mw	142	23	)	)	-RRB-
cord-007084-4niom5mw	142	24	.	.	.
cord-007084-4niom5mw	143	1	In	in	IN
cord-007084-4niom5mw	143	2	contrast	contrast	NN
cord-007084-4niom5mw	143	3	,	,	,
cord-007084-4niom5mw	143	4	addition	addition	NN
cord-007084-4niom5mw	143	5	of	of	IN
cord-007084-4niom5mw	143	6	oxygenated	oxygenated	JJ
cord-007084-4niom5mw	143	7	sterol	sterol	NN
cord-007084-4niom5mw	143	8	(	(	-LRB-
cord-007084-4niom5mw	143	9	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	143	10	)	)	-RRB-
cord-007084-4niom5mw	143	11	greatly	greatly	RB
cord-007084-4niom5mw	143	12	enhanced	enhance	VBN
cord-007084-4niom5mw	143	13	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	143	14	production	production	NN
cord-007084-4niom5mw	143	15	,	,	,
cord-007084-4niom5mw	143	16	and	and	CC
cord-007084-4niom5mw	143	17	again	again	RB
cord-007084-4niom5mw	143	18	this	this	DT
cord-007084-4niom5mw	143	19	effect	effect	NN
cord-007084-4niom5mw	143	20	was	be	VBD
cord-007084-4niom5mw	143	21	biphasic	biphasic	JJ
cord-007084-4niom5mw	143	22	.	.	.
cord-007084-4niom5mw	144	1	Furthermore	furthermore	RB
cord-007084-4niom5mw	144	2	,	,	,
cord-007084-4niom5mw	144	3	at	at	IN
cord-007084-4niom5mw	144	4	each	each	DT
cord-007084-4niom5mw	144	5	time	time	NN
cord-007084-4niom5mw	144	6	point	point	NN
cord-007084-4niom5mw	144	7	studied	study	VBD
cord-007084-4niom5mw	144	8	,	,	,
cord-007084-4niom5mw	144	9	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	144	10	from	from	IN
cord-007084-4niom5mw	144	11	senescent	senescent	JJ
cord-007084-4niom5mw	144	12	rats	rat	NNS
cord-007084-4niom5mw	144	13	synthesized	synthesize	VBD
cord-007084-4niom5mw	144	14	2	2	CD
cord-007084-4niom5mw	144	15	-	-	SYM
cord-007084-4niom5mw	144	16	3	3	CD
cord-007084-4niom5mw	144	17	times	time	NNS
cord-007084-4niom5mw	144	18	more	more	JJR
cord-007084-4niom5mw	144	19	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	144	20	compared	compare	VBN
cord-007084-4niom5mw	144	21	to	to	IN
cord-007084-4niom5mw	144	22	corresponding	correspond	VBG
cord-007084-4niom5mw	144	23	values	value	NNS
cord-007084-4niom5mw	144	24	from	from	IN
cord-007084-4niom5mw	144	25	young	young	JJ
cord-007084-4niom5mw	144	26	control	control	NN
cord-007084-4niom5mw	144	27	groups	group	NNS
cord-007084-4niom5mw	144	28	.	.	.
cord-007084-4niom5mw	145	1	Similarly	similarly	RB
cord-007084-4niom5mw	145	2	,	,	,
cord-007084-4niom5mw	145	3	the	the	DT
cord-007084-4niom5mw	145	4	rate	rate	NN
cord-007084-4niom5mw	145	5	of	of	IN
cord-007084-4niom5mw	145	6	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	145	7	formation	formation	NN
cord-007084-4niom5mw	145	8	was	be	VBD
cord-007084-4niom5mw	145	9	linear	linear	JJ
cord-007084-4niom5mw	145	10	with	with	IN
cord-007084-4niom5mw	145	11	protein	protein	NN
cord-007084-4niom5mw	145	12	concentration	concentration	NN
cord-007084-4niom5mw	145	13	up	up	IN
cord-007084-4niom5mw	145	14	to	to	IN
cord-007084-4niom5mw	145	15	100	100	CD
cord-007084-4niom5mw	145	16	/Kg	/Kg	NNS
cord-007084-4niom5mw	145	17	/	/	SYM
cord-007084-4niom5mw	145	18	ml	ml	XX
cord-007084-4niom5mw	145	19	in	in	IN
cord-007084-4niom5mw	145	20	both	both	DT
cord-007084-4niom5mw	145	21	age	age	NN
cord-007084-4niom5mw	145	22	groups	group	NNS
cord-007084-4niom5mw	145	23	examined	examine	VBD
cord-007084-4niom5mw	145	24	(	(	-LRB-
cord-007084-4niom5mw	145	25	Fig	Fig	NNP
cord-007084-4niom5mw	145	26	.	.	.
cord-007084-4niom5mw	145	27	 	 	_SP
cord-007084-4niom5mw	145	28	2	2	CD
cord-007084-4niom5mw	145	29	)	)	-RRB-
cord-007084-4niom5mw	145	30	.	.	.
cord-007084-4niom5mw	146	1	Like	like	IN
cord-007084-4niom5mw	146	2	time	time	NN
cord-007084-4niom5mw	146	3	-	-	HYPH
cord-007084-4niom5mw	146	4	course	course	NN
cord-007084-4niom5mw	146	5	studies	study	NNS
cord-007084-4niom5mw	146	6	,	,	,
cord-007084-4niom5mw	146	7	enzyme	enzyme	NN
cord-007084-4niom5mw	146	8	concentration	concentration	NN
cord-007084-4niom5mw	146	9	studies	study	NNS
cord-007084-4niom5mw	146	10	also	also	RB
cord-007084-4niom5mw	146	11	revealed	reveal	VBD
cord-007084-4niom5mw	146	12	enhanced	enhance	VBN
cord-007084-4niom5mw	146	13	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	146	14	capacity	capacity	NN
cord-007084-4niom5mw	146	15	of	of	IN
cord-007084-4niom5mw	146	16	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	146	17	from	from	IN
cord-007084-4niom5mw	146	18	12-month	12-month	JJ
cord-007084-4niom5mw	146	19	-	-	HYPH
cord-007084-4niom5mw	146	20	old	old	JJ
cord-007084-4niom5mw	146	21	rats	rat	NNS
cord-007084-4niom5mw	146	22	,	,	,
cord-007084-4niom5mw	146	23	and	and	CC
cord-007084-4niom5mw	146	24	this	this	DT
cord-007084-4niom5mw	146	25	effect	effect	NN
cord-007084-4niom5mw	146	26	was	be	VBD
cord-007084-4niom5mw	146	27	potentiated	potentiate	VBN
cord-007084-4niom5mw	146	28	in	in	IN
cord-007084-4niom5mw	146	29	the	the	DT
cord-007084-4niom5mw	146	30	presence	presence	NN
cord-007084-4niom5mw	146	31	of	of	IN
cord-007084-4niom5mw	146	32	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	146	33	.	.	.
cord-007084-4niom5mw	147	1	We	-PRON-	PRP
cord-007084-4niom5mw	147	2	next	next	RB
cord-007084-4niom5mw	147	3	examined	examine	VBD
cord-007084-4niom5mw	147	4	the	the	DT
cord-007084-4niom5mw	147	5	side	side	NN
cord-007084-4niom5mw	147	6	-	-	HYPH
cord-007084-4niom5mw	147	7	chain	chain	NN
cord-007084-4niom5mw	147	8	cleavage	cleavage	NN
cord-007084-4niom5mw	147	9	enzyme	enzyme	NN
cord-007084-4niom5mw	147	10	activity	activity	NN
cord-007084-4niom5mw	147	11	in	in	IN
cord-007084-4niom5mw	147	12	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	147	13	isolated	isolate	VBN
cord-007084-4niom5mw	147	14	from	from	IN
cord-007084-4niom5mw	147	15	rats	rat	NNS
cord-007084-4niom5mw	147	16	2	2	CD
cord-007084-4niom5mw	147	17	,	,	,
cord-007084-4niom5mw	147	18	12	12	CD
cord-007084-4niom5mw	147	19	,	,	,
cord-007084-4niom5mw	147	20	and	and	CC
cord-007084-4niom5mw	147	21	18	18	CD
cord-007084-4niom5mw	147	22	months	month	NNS
cord-007084-4niom5mw	147	23	of	of	IN
cord-007084-4niom5mw	147	24	age	age	NN
cord-007084-4niom5mw	147	25	,	,	,
cord-007084-4niom5mw	147	26	and	and	CC
cord-007084-4niom5mw	147	27	the	the	DT
cord-007084-4niom5mw	147	28	results	result	NNS
cord-007084-4niom5mw	147	29	are	be	VBP
cord-007084-4niom5mw	147	30	presented	present	VBN
cord-007084-4niom5mw	147	31	in	in	IN
cord-007084-4niom5mw	147	32	Fig	Fig	NNP
cord-007084-4niom5mw	147	33	.	.	.
cord-007084-4niom5mw	148	1	3	3	LS
cord-007084-4niom5mw	148	2	.	.	.
cord-007084-4niom5mw	149	1	Under	under	IN
cord-007084-4niom5mw	149	2	basal	basal	NN
cord-007084-4niom5mw	149	3	conditions	condition	NNS
cord-007084-4niom5mw	149	4	(	(	-LRB-
cord-007084-4niom5mw	149	5	without	without	IN
cord-007084-4niom5mw	149	6	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	149	7	)	)	-RRB-
cord-007084-4niom5mw	149	8	,	,	,
cord-007084-4niom5mw	149	9	cholesterol	cholesterol	NN
cord-007084-4niom5mw	149	10	side	side	NN
cord-007084-4niom5mw	149	11	-	-	HYPH
cord-007084-4niom5mw	149	12	chain	chain	NN
cord-007084-4niom5mw	149	13	cleavage	cleavage	NN
cord-007084-4niom5mw	149	14	activity	activity	NN
cord-007084-4niom5mw	149	15	(	(	-LRB-
cord-007084-4niom5mw	149	16	expressed	express	VBN
cord-007084-4niom5mw	149	17	as	as	IN
cord-007084-4niom5mw	149	18	nanomoles	nanomole	NNS
cord-007084-4niom5mw	149	19	of	of	IN
cord-007084-4niom5mw	149	20	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	149	21	produced	produce	VBN
cord-007084-4niom5mw	149	22	per	per	IN
cord-007084-4niom5mw	149	23	min	min	NNP
cord-007084-4niom5mw	149	24	mg	mg	NNP
cord-007084-4niom5mw	149	25	protein	protein	NN
cord-007084-4niom5mw	149	26	"	"	''
cord-007084-4niom5mw	149	27	1	1	CD
cord-007084-4niom5mw	149	28	)	)	-RRB-
cord-007084-4niom5mw	149	29	increased	increase	VBN
cord-007084-4niom5mw	149	30	(	(	-LRB-
cord-007084-4niom5mw	149	31	P	p	NN
cord-007084-4niom5mw	149	32	<	<	XX
cord-007084-4niom5mw	149	33	0.001	0.001	CD
cord-007084-4niom5mw	149	34	)	)	-RRB-
cord-007084-4niom5mw	149	35	from	from	IN
cord-007084-4niom5mw	149	36	a	a	DT
cord-007084-4niom5mw	149	37	mean	mean	NN
cord-007084-4niom5mw	149	38	(	(	-LRB-
cord-007084-4niom5mw	149	39	±SE	±se	NN
cord-007084-4niom5mw	149	40	)	)	-RRB-
cord-007084-4niom5mw	149	41	of	of	IN
cord-007084-4niom5mw	149	42	0.43	0.43	CD
cord-007084-4niom5mw	149	43	±	±	CD
cord-007084-4niom5mw	149	44	0.06	0.06	CD
cord-007084-4niom5mw	149	45	in	in	IN
cord-007084-4niom5mw	149	46	2-month	2-month	JJ
cord-007084-4niom5mw	149	47	-	-	HYPH
cord-007084-4niom5mw	149	48	old	old	JJ
cord-007084-4niom5mw	149	49	rats	rat	NNS
cord-007084-4niom5mw	149	50	to	to	IN
cord-007084-4niom5mw	149	51	1.26	1.26	CD
cord-007084-4niom5mw	149	52	±	±	CD
cord-007084-4niom5mw	149	53	0.11	0.11	CD
cord-007084-4niom5mw	149	54	and	and	CC
cord-007084-4niom5mw	149	55	1.51	1.51	CD
cord-007084-4niom5mw	149	56	±	±	CD
cord-007084-4niom5mw	149	57	0.06	0.06	CD
cord-007084-4niom5mw	149	58	in	in	IN
cord-007084-4niom5mw	149	59	the	the	DT
cord-007084-4niom5mw	149	60	12-and	12-and	CD
cord-007084-4niom5mw	149	61	18-month	18-month	JJ
cord-007084-4niom5mw	149	62	-	-	HYPH
cord-007084-4niom5mw	149	63	old	old	JJ
cord-007084-4niom5mw	149	64	rats	rat	NNS
cord-007084-4niom5mw	149	65	,	,	,
cord-007084-4niom5mw	149	66	respectively	respectively	RB
cord-007084-4niom5mw	149	67	.	.	.
cord-007084-4niom5mw	150	1	Similarly	similarly	RB
cord-007084-4niom5mw	150	2	,	,	,
cord-007084-4niom5mw	150	3	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	150	4	isolated	isolate	VBN
cord-007084-4niom5mw	150	5	from	from	IN
cord-007084-4niom5mw	150	6	12-and	12-and	CD
cord-007084-4niom5mw	150	7	18-month	18-month	JJ
cord-007084-4niom5mw	150	8	-	-	HYPH
cord-007084-4niom5mw	150	9	old	old	JJ
cord-007084-4niom5mw	150	10	rats	rat	NNS
cord-007084-4niom5mw	150	11	showed	show	VBD
cord-007084-4niom5mw	150	12	significantly	significantly	RB
cord-007084-4niom5mw	150	13	higher	high	JJR
cord-007084-4niom5mw	150	14	activity	activity	NN
cord-007084-4niom5mw	150	15	in	in	IN
cord-007084-4niom5mw	150	16	the	the	DT
cord-007084-4niom5mw	150	17	presence	presence	NN
cord-007084-4niom5mw	150	18	of	of	IN
cord-007084-4niom5mw	150	19	more	more	RBR
cord-007084-4niom5mw	150	20	polar	polar	JJ
cord-007084-4niom5mw	150	21	exogenous	exogenous	JJ
cord-007084-4niom5mw	150	22	substrate	substrate	NN
cord-007084-4niom5mw	150	23	(	(	-LRB-
cord-007084-4niom5mw	150	24	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	150	25	)	)	-RRB-
cord-007084-4niom5mw	150	26	compared	compare	VBN
cord-007084-4niom5mw	150	27	to	to	IN
cord-007084-4niom5mw	150	28	the	the	DT
cord-007084-4niom5mw	150	29	2-month	2-month	JJ
cord-007084-4niom5mw	150	30	-	-	HYPH
cord-007084-4niom5mw	150	31	old	old	JJ
cord-007084-4niom5mw	150	32	groups	group	NNS
cord-007084-4niom5mw	150	33	(	(	-LRB-
cord-007084-4niom5mw	150	34	18-month	18-month	JJ
cord-007084-4niom5mw	150	35	-	-	HYPH
cord-007084-4niom5mw	150	36	old	old	JJ
cord-007084-4niom5mw	150	37	,	,	,
cord-007084-4niom5mw	150	38	16	16	CD
cord-007084-4niom5mw	150	39	±	±	NNP
cord-007084-4niom5mw	150	40	1.4	1.4	CD
cord-007084-4niom5mw	150	41	;	;	:
cord-007084-4niom5mw	150	42	12-month	12-month	JJ
cord-007084-4niom5mw	150	43	-	-	HYPH
cord-007084-4niom5mw	150	44	old	old	JJ
cord-007084-4niom5mw	150	45	,	,	,
cord-007084-4niom5mw	150	46	12.4	12.4	CD
cord-007084-4niom5mw	150	47	±	±	CD
cord-007084-4niom5mw	150	48	1.2	1.2	CD
cord-007084-4niom5mw	150	49	;	;	:
cord-007084-4niom5mw	150	50	2-month	2-month	JJ
cord-007084-4niom5mw	150	51	-	-	HYPH
cord-007084-4niom5mw	150	52	old	old	JJ
cord-007084-4niom5mw	150	53	,	,	,
cord-007084-4niom5mw	150	54	5.0	5.0	CD
cord-007084-4niom5mw	150	55	±	±	CD
cord-007084-4niom5mw	150	56	0.6	0.6	CD
cord-007084-4niom5mw	150	57	)	)	-RRB-
cord-007084-4niom5mw	150	58	.	.	.
cord-007084-4niom5mw	151	1	All	all	DT
cord-007084-4niom5mw	151	2	of	of	IN
cord-007084-4niom5mw	151	3	these	these	DT
cord-007084-4niom5mw	151	4	enzyme	enzyme	NN
cord-007084-4niom5mw	151	5	assays	assay	NNS
cord-007084-4niom5mw	151	6	were	be	VBD
cord-007084-4niom5mw	151	7	carried	carry	VBN
cord-007084-4niom5mw	151	8	out	out	RP
cord-007084-4niom5mw	151	9	under	under	IN
cord-007084-4niom5mw	151	10	a	a	DT
cord-007084-4niom5mw	151	11	nearlinear	nearlinear	JJ
cord-007084-4niom5mw	151	12	range	range	NN
cord-007084-4niom5mw	151	13	of	of	IN
cord-007084-4niom5mw	151	14	time	time	NN
cord-007084-4niom5mw	151	15	and	and	CC
cord-007084-4niom5mw	151	16	enzyme	enzyme	NN
cord-007084-4niom5mw	151	17	protein	protein	NN
cord-007084-4niom5mw	151	18	concentration	concentration	NN
cord-007084-4niom5mw	151	19	.	.	.
cord-007084-4niom5mw	152	1	Thus	thus	RB
cord-007084-4niom5mw	152	2	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	152	3	isolated	isolate	VBN
cord-007084-4niom5mw	152	4	from	from	IN
cord-007084-4niom5mw	152	5	the	the	DT
cord-007084-4niom5mw	152	6	12-or	12-or	CD
cord-007084-4niom5mw	152	7	18-month-	18-month-	CD
cord-007084-4niom5mw	152	8	old	old	JJ
cord-007084-4niom5mw	152	9	rats	rat	NNS
cord-007084-4niom5mw	152	10	exhibited	exhibit	VBD
cord-007084-4niom5mw	152	11	an	an	DT
cord-007084-4niom5mw	152	12	enhanced	enhance	VBN
cord-007084-4niom5mw	152	13	capacity	capacity	NN
cord-007084-4niom5mw	152	14	to	to	TO
cord-007084-4niom5mw	152	15	synthesize	synthesize	VB
cord-007084-4niom5mw	152	16	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	152	17	compared	compare	VBN
cord-007084-4niom5mw	152	18	to	to	IN
cord-007084-4niom5mw	152	19	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	152	20	from	from	IN
cord-007084-4niom5mw	152	21	control	control	NN
cord-007084-4niom5mw	152	22	groups	group	NNS
cord-007084-4niom5mw	152	23	.	.	.
cord-007084-4niom5mw	153	1	Moreover	moreover	RB
cord-007084-4niom5mw	153	2	,	,	,
cord-007084-4niom5mw	153	3	addition	addition	NN
cord-007084-4niom5mw	153	4	of	of	IN
cord-007084-4niom5mw	153	5	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-007084-4niom5mw	153	6	produced	produce	VBD
cord-007084-4niom5mw	153	7	a	a	DT
cord-007084-4niom5mw	153	8	further	further	JJ
cord-007084-4niom5mw	153	9	substantial	substantial	JJ
cord-007084-4niom5mw	153	10	increase	increase	NN
cord-007084-4niom5mw	153	11	in	in	IN
cord-007084-4niom5mw	153	12	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	153	13	formation	formation	NN
cord-007084-4niom5mw	153	14	in	in	IN
cord-007084-4niom5mw	153	15	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	153	16	isolated	isolate	VBN
cord-007084-4niom5mw	153	17	from	from	IN
cord-007084-4niom5mw	153	18	older	old	JJR
cord-007084-4niom5mw	153	19	animals	animal	NNS
cord-007084-4niom5mw	153	20	,	,	,
cord-007084-4niom5mw	153	21	and	and	CC
cord-007084-4niom5mw	153	22	levels	level	NNS
cord-007084-4niom5mw	153	23	were	be	VBD
cord-007084-4niom5mw	153	24	significantly	significantly	RB
cord-007084-4niom5mw	153	25	higher	high	JJR
cord-007084-4niom5mw	153	26	than	than	IN
cord-007084-4niom5mw	153	27	those	those	DT
cord-007084-4niom5mw	153	28	in	in	IN
cord-007084-4niom5mw	153	29	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	153	30	from	from	IN
cord-007084-4niom5mw	153	31	control	control	NN
cord-007084-4niom5mw	153	32	groups	group	NNS
cord-007084-4niom5mw	153	33	.	.	.
cord-007084-4niom5mw	154	1	In	in	IN
cord-007084-4niom5mw	154	2	contrast	contrast	NN
cord-007084-4niom5mw	154	3	to	to	IN
cord-007084-4niom5mw	154	4	progressive	progressive	JJ
cord-007084-4niom5mw	154	5	changes	change	NNS
cord-007084-4niom5mw	154	6	in	in	IN
cord-007084-4niom5mw	154	7	side	side	NN
cord-007084-4niom5mw	154	8	-	-	HYPH
cord-007084-4niom5mw	154	9	chain	chain	NN
cord-007084-4niom5mw	154	10	cleavage	cleavage	NN
cord-007084-4niom5mw	154	11	activity	activity	NN
cord-007084-4niom5mw	154	12	,	,	,
cord-007084-4niom5mw	154	13	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	154	14	cytochrome	cytochrome	NN
cord-007084-4niom5mw	154	15	-	-	HYPH
cord-007084-4niom5mw	154	16	P450	p450	JJ
cord-007084-4niom5mw	154	17	contents	content	NNS
cord-007084-4niom5mw	154	18	did	do	VBD
cord-007084-4niom5mw	154	19	not	not	RB
cord-007084-4niom5mw	154	20	change	change	VB
cord-007084-4niom5mw	154	21	with	with	IN
cord-007084-4niom5mw	154	22	age	age	NN
cord-007084-4niom5mw	154	23	(	(	-LRB-
cord-007084-4niom5mw	154	24	Table	table	NN
cord-007084-4niom5mw	154	25	1	1	CD
cord-007084-4niom5mw	154	26	)	)	-RRB-
cord-007084-4niom5mw	154	27	.	.	.
cord-007084-4niom5mw	155	1	A	a	DT
cord-007084-4niom5mw	155	2	comparison	comparison	NN
cord-007084-4niom5mw	155	3	of	of	IN
cord-007084-4niom5mw	155	4	the	the	DT
cord-007084-4niom5mw	155	5	activities	activity	NNS
cord-007084-4niom5mw	155	6	of	of	IN
cord-007084-4niom5mw	155	7	other	other	JJ
cord-007084-4niom5mw	155	8	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	155	9	enzymes	enzyme	NNS
cord-007084-4niom5mw	155	10	,	,	,
cord-007084-4niom5mw	155	11	3/3-HSD	3/3-HSD	VBD
cord-007084-4niom5mw	155	12	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	155	13	,	,	,
cord-007084-4niom5mw	155	14	and	and	CC
cord-007084-4niom5mw	155	15	11	11	CD
cord-007084-4niom5mw	155	16	/	/	SYM
cord-007084-4niom5mw	155	17	Miydroxylase	Miydroxylase	NNP
cord-007084-4niom5mw	155	18	,	,	,
cord-007084-4niom5mw	155	19	in	in	IN
cord-007084-4niom5mw	155	20	microsomal	microsomal	NN
cord-007084-4niom5mw	155	21	and	and	CC
cord-007084-4niom5mw	155	22	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	155	23	fractions	fraction	NNS
cord-007084-4niom5mw	155	24	of	of	IN
cord-007084-4niom5mw	155	25	adrenals	adrenal	NNS
cord-007084-4niom5mw	155	26	from	from	IN
cord-007084-4niom5mw	155	27	2-and	2-and	CD
cord-007084-4niom5mw	155	28	12-month	12-month	JJ
cord-007084-4niom5mw	155	29	-	-	HYPH
cord-007084-4niom5mw	155	30	old	old	JJ
cord-007084-4niom5mw	155	31	animals	animal	NNS
cord-007084-4niom5mw	155	32	is	be	VBZ
cord-007084-4niom5mw	155	33	shown	show	VBN
cord-007084-4niom5mw	155	34	in	in	IN
cord-007084-4niom5mw	155	35	Table	Table	NNP
cord-007084-4niom5mw	155	36	2	2	CD
cord-007084-4niom5mw	155	37	.	.	.
cord-007084-4niom5mw	156	1	No	no	DT
cord-007084-4niom5mw	156	2	significant	significant	JJ
cord-007084-4niom5mw	156	3	age	age	NN
cord-007084-4niom5mw	156	4	-	-	HYPH
cord-007084-4niom5mw	156	5	related	relate	VBN
cord-007084-4niom5mw	156	6	changes	change	NNS
cord-007084-4niom5mw	156	7	were	be	VBD
cord-007084-4niom5mw	156	8	noted	note	VBN
cord-007084-4niom5mw	156	9	for	for	IN
cord-007084-4niom5mw	156	10	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	156	11	(	(	-LRB-
cord-007084-4niom5mw	157	1	29.8	29.8	CD
cord-007084-4niom5mw	157	2	±	±	CD
cord-007084-4niom5mw	157	3	1.2	1.2	CD
cord-007084-4niom5mw	157	4	nmol	nmol	JJ
cord-007084-4niom5mw	157	5	min	min	NNP
cord-007084-4niom5mw	157	6	"	"	''
cord-007084-4niom5mw	157	7	1	1	CD
cord-007084-4niom5mw	157	8	mg	mg	NNP
cord-007084-4niom5mw	157	9	protein	protein	NN
cord-007084-4niom5mw	157	10	"	"	''
cord-007084-4niom5mw	157	11	1	1	CD
cord-007084-4niom5mw	157	12	in	in	IN
cord-007084-4niom5mw	158	1	2-monthold	2-monthold	CD
cord-007084-4niom5mw	158	2	rats	rat	NNS
cord-007084-4niom5mw	158	3	us	-PRON-	PRP
cord-007084-4niom5mw	158	4	.	.	.
cord-007084-4niom5mw	159	1	29.5	29.5	CD
cord-007084-4niom5mw	159	2	±	±	CD
cord-007084-4niom5mw	159	3	2.2	2.2	CD
cord-007084-4niom5mw	159	4	nmol	nmol	JJ
cord-007084-4niom5mw	159	5	min	min	NNP
cord-007084-4niom5mw	159	6	"	"	''
cord-007084-4niom5mw	159	7	1	1	CD
cord-007084-4niom5mw	159	8	mg	mg	NNP
cord-007084-4niom5mw	159	9	protein	protein	NN
cord-007084-4niom5mw	159	10	"	"	''
cord-007084-4niom5mw	159	11	1	1	CD
cord-007084-4niom5mw	159	12	in	in	IN
cord-007084-4niom5mw	159	13	12month	12month	JJ
cord-007084-4niom5mw	159	14	-	-	HYPH
cord-007084-4niom5mw	159	15	old	old	JJ
cord-007084-4niom5mw	159	16	rats	rat	NNS
cord-007084-4niom5mw	159	17	;	;	:
cord-007084-4niom5mw	159	18	P	p	NN
cord-007084-4niom5mw	159	19	=	=	SYM
cord-007084-4niom5mw	159	20	NS	NS	NNP
cord-007084-4niom5mw	159	21	)	)	-RRB-
cord-007084-4niom5mw	159	22	.	.	.
cord-007084-4niom5mw	160	1	Similarly	similarly	RB
cord-007084-4niom5mw	160	2	,	,	,
cord-007084-4niom5mw	160	3	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	160	4	110hydroxylase	110hydroxylase	NN
cord-007084-4niom5mw	160	5	activity	activity	NN
cord-007084-4niom5mw	160	6	was	be	VBD
cord-007084-4niom5mw	160	7	comparable	comparable	JJ
cord-007084-4niom5mw	160	8	in	in	IN
cord-007084-4niom5mw	160	9	both	both	DT
cord-007084-4niom5mw	160	10	age	age	NN
cord-007084-4niom5mw	160	11	groups	group	NNS
cord-007084-4niom5mw	160	12	examined	examine	VBD
cord-007084-4niom5mw	160	13	(	(	-LRB-
cord-007084-4niom5mw	160	14	1.21	1.21	CD
cord-007084-4niom5mw	160	15	±	±	CD
cord-007084-4niom5mw	160	16	0.15	0.15	CD
cord-007084-4niom5mw	160	17	nmol	nmol	NNP
cord-007084-4niom5mw	160	18	min	min	NNP
cord-007084-4niom5mw	160	19	"	"	''
cord-007084-4niom5mw	160	20	1	1	CD
cord-007084-4niom5mw	160	21	mg	mg	NNP
cord-007084-4niom5mw	160	22	protein	protein	NN
cord-007084-4niom5mw	160	23	"	"	''
cord-007084-4niom5mw	160	24	1	1	CD
cord-007084-4niom5mw	160	25	in	in	IN
cord-007084-4niom5mw	160	26	2month	2month	JJ
cord-007084-4niom5mw	160	27	-	-	HYPH
cord-007084-4niom5mw	160	28	olds	old	NNS
cord-007084-4niom5mw	160	29	us	-PRON-	PRP
cord-007084-4niom5mw	160	30	.	.	.
cord-007084-4niom5mw	161	1	1.19	1.19	CD
cord-007084-4niom5mw	161	2	±	±	CD
cord-007084-4niom5mw	161	3	0.09	0.09	CD
cord-007084-4niom5mw	161	4	nmol	nmol	NNP
cord-007084-4niom5mw	161	5	min	min	NNP
cord-007084-4niom5mw	161	6	"	"	``
cord-007084-4niom5mw	161	7	1	1	CD
cord-007084-4niom5mw	161	8	mg	mg	NNP
cord-007084-4niom5mw	161	9	protein	protein	NN
cord-007084-4niom5mw	161	10	"	"	''
cord-007084-4niom5mw	161	11	1	1	CD
cord-007084-4niom5mw	161	12	in	in	IN
cord-007084-4niom5mw	161	13	12-month	12-month	JJ
cord-007084-4niom5mw	161	14	-	-	HYPH
cord-007084-4niom5mw	161	15	olds	old	NNS
cord-007084-4niom5mw	161	16	;	;	:
cord-007084-4niom5mw	161	17	P	p	NN
cord-007084-4niom5mw	161	18	=	=	SYM
cord-007084-4niom5mw	161	19	NS	NS	NNP
cord-007084-4niom5mw	161	20	)	)	-RRB-
cord-007084-4niom5mw	161	21	.	.	.
cord-007084-4niom5mw	162	1	In	in	IN
cord-007084-4niom5mw	162	2	contrast	contrast	JJ
cord-007084-4niom5mw	162	3	microsomal	microsomal	NN
cord-007084-4niom5mw	162	4	21hydroxylase	21hydroxylase	CD
cord-007084-4niom5mw	162	5	activity	activity	NN
cord-007084-4niom5mw	162	6	was	be	VBD
cord-007084-4niom5mw	162	7	slightly	slightly	RB
cord-007084-4niom5mw	162	8	but	but	CC
cord-007084-4niom5mw	162	9	significantly	significantly	RB
cord-007084-4niom5mw	162	10	(	(	-LRB-
cord-007084-4niom5mw	162	11	P	p	NN
cord-007084-4niom5mw	162	12	<	<	XX
cord-007084-4niom5mw	162	13	0.001	0.001	CD
cord-007084-4niom5mw	162	14	)	)	-RRB-
cord-007084-4niom5mw	162	15	increased	increase	VBD
cord-007084-4niom5mw	162	16	in	in	IN
cord-007084-4niom5mw	162	17	12-month	12-month	JJ
cord-007084-4niom5mw	162	18	-	-	HYPH
cord-007084-4niom5mw	162	19	old	old	JJ
cord-007084-4niom5mw	162	20	rats	rat	NNS
cord-007084-4niom5mw	162	21	(	(	-LRB-
cord-007084-4niom5mw	163	1	7.7	7.7	CD
cord-007084-4niom5mw	163	2	±	±	CD
cord-007084-4niom5mw	163	3	0.5	0.5	CD
cord-007084-4niom5mw	163	4	nmol	nmol	NN
cord-007084-4niom5mw	163	5	min	min	NNP
cord-007084-4niom5mw	163	6	"	"	''
cord-007084-4niom5mw	163	7	1	1	CD
cord-007084-4niom5mw	163	8	mg	mg	NNP
cord-007084-4niom5mw	163	9	protein	protein	NN
cord-007084-4niom5mw	163	10	"	"	''
cord-007084-4niom5mw	163	11	1	1	CD
cord-007084-4niom5mw	163	12	)	)	-RRB-
cord-007084-4niom5mw	163	13	compared	compare	VBN
cord-007084-4niom5mw	163	14	to	to	IN
cord-007084-4niom5mw	163	15	that	that	DT
cord-007084-4niom5mw	163	16	in	in	IN
cord-007084-4niom5mw	163	17	2-month	2-month	JJ
cord-007084-4niom5mw	163	18	-	-	HYPH
cord-007084-4niom5mw	163	19	old	old	JJ
cord-007084-4niom5mw	163	20	animals	animal	NNS
cord-007084-4niom5mw	163	21	(	(	-LRB-
cord-007084-4niom5mw	163	22	5.2	5.2	CD
cord-007084-4niom5mw	163	23	±	±	NNP
cord-007084-4niom5mw	163	24	0.2	0.2	CD
cord-007084-4niom5mw	163	25	nmol	nmol	NNP
cord-007084-4niom5mw	163	26	min	min	NNP
cord-007084-4niom5mw	163	27	"	"	''
cord-007084-4niom5mw	163	28	1	1	CD
cord-007084-4niom5mw	163	29	mg	mg	NNP
cord-007084-4niom5mw	163	30	protein	protein	NN
cord-007084-4niom5mw	163	31	"	"	''
cord-007084-4niom5mw	163	32	1	1	CD
cord-007084-4niom5mw	163	33	)	)	-RRB-
cord-007084-4niom5mw	163	34	.	.	.
cord-007084-4niom5mw	164	1	Mean	mean	JJ
cord-007084-4niom5mw	164	2	activities	activity	NNS
cord-007084-4niom5mw	164	3	(	(	-LRB-
cord-007084-4niom5mw	164	4	±SE	±se	NN
cord-007084-4niom5mw	164	5	)	)	-RRB-
cord-007084-4niom5mw	164	6	of	of	IN
cord-007084-4niom5mw	164	7	monoamine	monoamine	NN
cord-007084-4niom5mw	164	8	oxidase	oxidase	NN
cord-007084-4niom5mw	164	9	,	,	,
cord-007084-4niom5mw	164	10	amytalinsensitive	amytalinsensitive	JJ
cord-007084-4niom5mw	164	11	NADH	NADH	NNP
cord-007084-4niom5mw	164	12	cytochrome	cytochrome	NN
cord-007084-4niom5mw	164	13	c	c	NNP
cord-007084-4niom5mw	164	14	reductase	reductase	NN
cord-007084-4niom5mw	164	15	,	,	,
cord-007084-4niom5mw	164	16	succinate	succinate	NN
cord-007084-4niom5mw	164	17	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	164	18	,	,	,
cord-007084-4niom5mw	164	19	cytochrome	cytochrome	NN
cord-007084-4niom5mw	164	20	oxidase	oxidase	NN
cord-007084-4niom5mw	164	21	,	,	,
cord-007084-4niom5mw	164	22	and	and	CC
cord-007084-4niom5mw	164	23	malate	malate	NN
cord-007084-4niom5mw	164	24	dehydrogenase	dehydrogenase	NNP
cord-007084-4niom5mw	164	25	are	be	VBP
cord-007084-4niom5mw	164	26	presented	present	VBN
cord-007084-4niom5mw	164	27	in	in	IN
cord-007084-4niom5mw	164	28	Table	Table	NNP
cord-007084-4niom5mw	164	29	3	3	CD
cord-007084-4niom5mw	164	30	.	.	.
cord-007084-4niom5mw	165	1	Monoamine	monoamine	NN
cord-007084-4niom5mw	165	2	oxidase	oxidase	NN
cord-007084-4niom5mw	165	3	(	(	-LRB-
cord-007084-4niom5mw	165	4	33	33	CD
cord-007084-4niom5mw	165	5	,	,	,
cord-007084-4niom5mw	165	6	34	34	CD
cord-007084-4niom5mw	165	7	)	)	-RRB-
cord-007084-4niom5mw	165	8	and	and	CC
cord-007084-4niom5mw	165	9	amytal	amytal	JJ
cord-007084-4niom5mw	165	10	-	-	HYPH
cord-007084-4niom5mw	165	11	insensitive	insensitive	JJ
cord-007084-4niom5mw	165	12	Results	result	NNS
cord-007084-4niom5mw	165	13	are	be	VBP
cord-007084-4niom5mw	165	14	the	the	DT
cord-007084-4niom5mw	165	15	mean	mean	JJ
cord-007084-4niom5mw	165	16	±	±	NNP
cord-007084-4niom5mw	165	17	SE	SE	NNP
cord-007084-4niom5mw	165	18	.	.	.
cord-007084-4niom5mw	166	1	The	the	DT
cord-007084-4niom5mw	166	2	number	number	NN
cord-007084-4niom5mw	166	3	of	of	IN
cord-007084-4niom5mw	166	4	experiments	experiment	NNS
cord-007084-4niom5mw	166	5	is	be	VBZ
cord-007084-4niom5mw	166	6	given	give	VBN
cord-007084-4niom5mw	166	7	in	in	IN
cord-007084-4niom5mw	166	8	parentheses	parenthesis	NNS
cord-007084-4niom5mw	166	9	.	.	.
cord-007084-4niom5mw	167	1	"	"	``
cord-007084-4niom5mw	167	2	Expressed	express	VBN
cord-007084-4niom5mw	167	3	as	as	IN
cord-007084-4niom5mw	167	4	nanomoles	nanomole	NNS
cord-007084-4niom5mw	167	5	of	of	IN
cord-007084-4niom5mw	167	6	progesterone	progesterone	NN
cord-007084-4niom5mw	167	7	produced	produce	VBN
cord-007084-4niom5mw	167	8	per	per	IN
cord-007084-4niom5mw	167	9	min	min	NNP
cord-007084-4niom5mw	167	10	mg	mg	NNP
cord-007084-4niom5mw	167	11	protein	protein	NN
cord-007084-4niom5mw	167	12	"	"	''
cord-007084-4niom5mw	167	13	1	1	CD
cord-007084-4niom5mw	167	14	.	.	.
cord-007084-4niom5mw	167	15	6	6	CD
cord-007084-4niom5mw	167	16	Expressed	express	VBD
cord-007084-4niom5mw	167	17	as	as	IN
cord-007084-4niom5mw	167	18	nanomoles	nanomole	NNS
cord-007084-4niom5mw	167	19	of	of	IN
cord-007084-4niom5mw	167	20	deoxycorticosterone	deoxycorticosterone	NNP
cord-007084-4niom5mw	167	21	produced	produce	VBN
cord-007084-4niom5mw	167	22	per	per	IN
cord-007084-4niom5mw	167	23	min	min	NNP
cord-007084-4niom5mw	167	24	mg	mg	NNP
cord-007084-4niom5mw	167	25	protein	protein	NN
cord-007084-4niom5mw	167	26	"	"	''
cord-007084-4niom5mw	167	27	1	1	CD
cord-007084-4niom5mw	167	28	.	.	.
cord-007084-4niom5mw	168	1	c	c	NNP
cord-007084-4niom5mw	168	2	Expressed	express	VBD
cord-007084-4niom5mw	168	3	as	as	IN
cord-007084-4niom5mw	168	4	nanomoles	nanomole	NNS
cord-007084-4niom5mw	168	5	of	of	IN
cord-007084-4niom5mw	168	6	corticosterone	corticosterone	NNP
cord-007084-4niom5mw	168	7	produced	produce	VBN
cord-007084-4niom5mw	168	8	per	per	IN
cord-007084-4niom5mw	168	9	min	min	NNP
cord-007084-4niom5mw	168	10	mg	mg	NNP
cord-007084-4niom5mw	168	11	protein	protein	NN
cord-007084-4niom5mw	168	12	"	"	''
cord-007084-4niom5mw	168	13	1	1	CD
cord-007084-4niom5mw	168	14	.	.	.
cord-007084-4niom5mw	169	1	Results	result	NNS
cord-007084-4niom5mw	169	2	are	be	VBP
cord-007084-4niom5mw	169	3	the	the	DT
cord-007084-4niom5mw	169	4	mean	mean	JJ
cord-007084-4niom5mw	169	5	±	±	NNP
cord-007084-4niom5mw	169	6	SE	SE	NNP
cord-007084-4niom5mw	169	7	of	of	IN
cord-007084-4niom5mw	169	8	eight	eight	CD
cord-007084-4niom5mw	169	9	separate	separate	JJ
cord-007084-4niom5mw	169	10	experiments	experiment	NNS
cord-007084-4niom5mw	169	11	.	.	.
cord-007084-4niom5mw	169	12	0	0	NFP
cord-007084-4niom5mw	170	1	Expressed	express	VBN
cord-007084-4niom5mw	170	2	as	as	IN
cord-007084-4niom5mw	170	3	nanomoles	nanomole	NNS
cord-007084-4niom5mw	170	4	of	of	IN
cord-007084-4niom5mw	170	5	benzaldehyde	benzaldehyde	NN
cord-007084-4niom5mw	170	6	produced	produce	VBN
cord-007084-4niom5mw	170	7	per	per	IN
cord-007084-4niom5mw	170	8	min	min	NN
cord-007084-4niom5mw	170	9	mg	mg	NNP
cord-007084-4niom5mw	170	10	protein	protein	NN
cord-007084-4niom5mw	170	11	"	"	''
cord-007084-4niom5mw	170	12	1	1	CD
cord-007084-4niom5mw	170	13	.	.	.
cord-007084-4niom5mw	170	14	6	6	CD
cord-007084-4niom5mw	170	15	Expressed	express	VBD
cord-007084-4niom5mw	170	16	as	as	IN
cord-007084-4niom5mw	170	17	nanomoles	nanomole	NNS
cord-007084-4niom5mw	170	18	of	of	IN
cord-007084-4niom5mw	170	19	cytochrome	cytochrome	NN
cord-007084-4niom5mw	170	20	c	c	NN
cord-007084-4niom5mw	170	21	reduced	reduce	VBN
cord-007084-4niom5mw	170	22	per	per	IN
cord-007084-4niom5mw	170	23	min	min	NNP
cord-007084-4niom5mw	170	24	mg	mg	NNP
cord-007084-4niom5mw	170	25	protein	protein	NN
cord-007084-4niom5mw	170	26	"	"	''
cord-007084-4niom5mw	170	27	1	1	CD
cord-007084-4niom5mw	170	28	.	.	.
cord-007084-4niom5mw	171	1	c	c	NNP
cord-007084-4niom5mw	171	2	Expressed	express	VBD
cord-007084-4niom5mw	171	3	as	as	IN
cord-007084-4niom5mw	171	4	nanomoles	nanomole	NNS
cord-007084-4niom5mw	171	5	of	of	IN
cord-007084-4niom5mw	171	6	iodonitrotetrazolium	iodonitrotetrazolium	NN
cord-007084-4niom5mw	171	7	reduced	reduce	VBN
cord-007084-4niom5mw	171	8	per	per	IN
cord-007084-4niom5mw	171	9	min	min	NNP
cord-007084-4niom5mw	171	10	mg	mg	NNP
cord-007084-4niom5mw	171	11	protein	protein	NN
cord-007084-4niom5mw	171	12	"	"	''
cord-007084-4niom5mw	171	13	1	1	CD
cord-007084-4niom5mw	171	14	.	.	.
cord-007084-4niom5mw	172	1	d	d	NNP
cord-007084-4niom5mw	172	2	Expressed	express	VBD
cord-007084-4niom5mw	172	3	as	as	IN
cord-007084-4niom5mw	172	4	nanomoles	nanomole	NNS
cord-007084-4niom5mw	172	5	of	of	IN
cord-007084-4niom5mw	172	6	cytochrome	cytochrome	NN
cord-007084-4niom5mw	172	7	c	c	NN
cord-007084-4niom5mw	172	8	oxidized	oxidize	VBN
cord-007084-4niom5mw	172	9	per	per	IN
cord-007084-4niom5mw	172	10	min	min	NN
cord-007084-4niom5mw	172	11	mg	mg	NNP
cord-007084-4niom5mw	172	12	protein	protein	NN
cord-007084-4niom5mw	172	13	"	"	''
cord-007084-4niom5mw	172	14	1	1	CD
cord-007084-4niom5mw	172	15	.	.	.
cord-007084-4niom5mw	173	1	e	e	LS
cord-007084-4niom5mw	173	2	Expressed	express	VBN
cord-007084-4niom5mw	173	3	as	as	IN
cord-007084-4niom5mw	173	4	nanomoles	nanomole	NNS
cord-007084-4niom5mw	173	5	of	of	IN
cord-007084-4niom5mw	173	6	NADH	NADH	NNP
cord-007084-4niom5mw	173	7	oxidized	oxidize	VBN
cord-007084-4niom5mw	173	8	per	per	IN
cord-007084-4niom5mw	173	9	min	min	NN
cord-007084-4niom5mw	173	10	mg	mg	NNP
cord-007084-4niom5mw	173	11	protein	protein	NN
cord-007084-4niom5mw	173	12	"	"	''
cord-007084-4niom5mw	173	13	1	1	CD
cord-007084-4niom5mw	173	14	.	.	.
cord-007084-4niom5mw	174	1	NADH	NADH	NNP
cord-007084-4niom5mw	174	2	cytochrome	cytochrome	NNP
cord-007084-4niom5mw	175	1	c	c	NNP
cord-007084-4niom5mw	175	2	reductase	reductase	NNP
cord-007084-4niom5mw	175	3	(	(	-LRB-
cord-007084-4niom5mw	175	4	18	18	CD
cord-007084-4niom5mw	175	5	,	,	,
cord-007084-4niom5mw	175	6	28	28	CD
cord-007084-4niom5mw	175	7	,	,	,
cord-007084-4niom5mw	175	8	29	29	CD
cord-007084-4niom5mw	175	9	,	,	,
cord-007084-4niom5mw	175	10	35	35	CD
cord-007084-4niom5mw	175	11	)	)	-RRB-
cord-007084-4niom5mw	175	12	are	be	VBP
cord-007084-4niom5mw	175	13	located	locate	VBN
cord-007084-4niom5mw	175	14	on	on	IN
cord-007084-4niom5mw	175	15	the	the	DT
cord-007084-4niom5mw	175	16	outer	outer	JJ
cord-007084-4niom5mw	175	17	mitochondrial	mitochondrial	NN
cord-007084-4niom5mw	175	18	membrane	membrane	NN
cord-007084-4niom5mw	175	19	and	and	CC
cord-007084-4niom5mw	175	20	were	be	VBD
cord-007084-4niom5mw	175	21	chosen	choose	VBN
cord-007084-4niom5mw	175	22	for	for	IN
cord-007084-4niom5mw	175	23	study	study	NN
cord-007084-4niom5mw	175	24	to	to	TO
cord-007084-4niom5mw	175	25	serve	serve	VB
cord-007084-4niom5mw	175	26	as	as	IN
cord-007084-4niom5mw	175	27	a	a	DT
cord-007084-4niom5mw	175	28	control	control	NN
cord-007084-4niom5mw	175	29	for	for	IN
cord-007084-4niom5mw	175	30	the	the	DT
cord-007084-4niom5mw	175	31	increase	increase	NN
cord-007084-4niom5mw	175	32	in	in	IN
cord-007084-4niom5mw	175	33	sidechain	sidechain	NN
cord-007084-4niom5mw	175	34	cleavage	cleavage	NN
cord-007084-4niom5mw	175	35	activity	activity	NN
cord-007084-4niom5mw	175	36	associated	associate	VBN
cord-007084-4niom5mw	175	37	with	with	IN
cord-007084-4niom5mw	175	38	preparation	preparation	NN
cord-007084-4niom5mw	175	39	of	of	IN
cord-007084-4niom5mw	175	40	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	175	41	fractions	fraction	NNS
cord-007084-4niom5mw	175	42	.	.	.
cord-007084-4niom5mw	176	1	Succinate	succinate	NN
cord-007084-4niom5mw	176	2	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	176	3	and	and	CC
cord-007084-4niom5mw	176	4	cytochrome	cytochrome	NN
cord-007084-4niom5mw	176	5	oxidase	oxidase	NN
cord-007084-4niom5mw	176	6	are	be	VBP
cord-007084-4niom5mw	176	7	conventional	conventional	JJ
cord-007084-4niom5mw	176	8	markers	marker	NNS
cord-007084-4niom5mw	176	9	of	of	IN
cord-007084-4niom5mw	176	10	the	the	DT
cord-007084-4niom5mw	176	11	inner	inner	JJ
cord-007084-4niom5mw	176	12	mitochondrial	mitochondrial	NN
cord-007084-4niom5mw	176	13	membrane	membrane	NN
cord-007084-4niom5mw	176	14	(	(	-LRB-
cord-007084-4niom5mw	176	15	26	26	CD
cord-007084-4niom5mw	176	16	)	)	-RRB-
cord-007084-4niom5mw	176	17	and	and	CC
cord-007084-4niom5mw	176	18	were	be	VBD
cord-007084-4niom5mw	176	19	chosen	choose	VBN
cord-007084-4niom5mw	176	20	as	as	IN
cord-007084-4niom5mw	176	21	a	a	DT
cord-007084-4niom5mw	176	22	control	control	NN
cord-007084-4niom5mw	176	23	for	for	IN
cord-007084-4niom5mw	176	24	the	the	DT
cord-007084-4niom5mw	176	25	possibility	possibility	NN
cord-007084-4niom5mw	176	26	that	that	IN
cord-007084-4niom5mw	176	27	age	age	NN
cord-007084-4niom5mw	176	28	leads	lead	VBZ
cord-007084-4niom5mw	176	29	to	to	IN
cord-007084-4niom5mw	176	30	a	a	DT
cord-007084-4niom5mw	176	31	generalized	generalized	JJ
cord-007084-4niom5mw	176	32	change	change	NN
cord-007084-4niom5mw	176	33	in	in	IN
cord-007084-4niom5mw	176	34	the	the	DT
cord-007084-4niom5mw	176	35	activity	activity	NN
cord-007084-4niom5mw	176	36	of	of	IN
cord-007084-4niom5mw	176	37	adrenal	adrenal	JJ
cord-007084-4niom5mw	176	38	enzymes	enzyme	NNS
cord-007084-4niom5mw	176	39	.	.	.
cord-007084-4niom5mw	177	1	Malate	Malate	NNP
cord-007084-4niom5mw	177	2	jdehydrogenase	jdehydrogenase	NNP
cord-007084-4niom5mw	177	3	is	be	VBZ
cord-007084-4niom5mw	177	4	a	a	DT
cord-007084-4niom5mw	177	5	classical	classical	JJ
cord-007084-4niom5mw	177	6	marker	marker	NN
cord-007084-4niom5mw	177	7	for	for	IN
cord-007084-4niom5mw	177	8	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	177	9	matrix	matrix	NN
cord-007084-4niom5mw	177	10	(	(	-LRB-
cord-007084-4niom5mw	177	11	26	26	CD
cord-007084-4niom5mw	177	12	,	,	,
cord-007084-4niom5mw	177	13	29	29	CD
cord-007084-4niom5mw	177	14	)	)	-RRB-
cord-007084-4niom5mw	177	15	and	and	CC
cord-007084-4niom5mw	177	16	was	be	VBD
cord-007084-4niom5mw	177	17	employed	employ	VBN
cord-007084-4niom5mw	177	18	to	to	TO
cord-007084-4niom5mw	177	19	serve	serve	VB
cord-007084-4niom5mw	177	20	as	as	IN
cord-007084-4niom5mw	177	21	a	a	DT
cord-007084-4niom5mw	177	22	control	control	NN
cord-007084-4niom5mw	177	23	for	for	IN
cord-007084-4niom5mw	177	24	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	177	25	integrity	integrity	NN
cord-007084-4niom5mw	177	26	.	.	.
cord-007084-4niom5mw	178	1	The	the	DT
cord-007084-4niom5mw	178	2	fact	fact	NN
cord-007084-4niom5mw	178	3	that	that	IN
cord-007084-4niom5mw	178	4	the	the	DT
cord-007084-4niom5mw	178	5	activity	activity	NN
cord-007084-4niom5mw	178	6	of	of	IN
cord-007084-4niom5mw	178	7	none	none	NN
cord-007084-4niom5mw	178	8	of	of	IN
cord-007084-4niom5mw	178	9	these	these	DT
cord-007084-4niom5mw	178	10	enzymes	enzyme	NNS
cord-007084-4niom5mw	178	11	changed	change	VBN
cord-007084-4niom5mw	178	12	as	as	IN
cord-007084-4niom5mw	178	13	rats	rat	NNS
cord-007084-4niom5mw	178	14	grew	grow	VBD
cord-007084-4niom5mw	178	15	older	old	JJR
cord-007084-4niom5mw	178	16	provides	provide	VBZ
cord-007084-4niom5mw	178	17	support	support	NN
cord-007084-4niom5mw	178	18	for	for	IN
cord-007084-4niom5mw	178	19	the	the	DT
cord-007084-4niom5mw	178	20	relative	relative	JJ
cord-007084-4niom5mw	178	21	specificity	specificity	NN
cord-007084-4niom5mw	178	22	of	of	IN
cord-007084-4niom5mw	178	23	the	the	DT
cord-007084-4niom5mw	178	24	age	age	NN
cord-007084-4niom5mw	178	25	-	-	HYPH
cord-007084-4niom5mw	178	26	related	relate	VBN
cord-007084-4niom5mw	178	27	increase	increase	NN
cord-007084-4niom5mw	178	28	in	in	IN
cord-007084-4niom5mw	178	29	cholesterol	cholesterol	NN
cord-007084-4niom5mw	178	30	side	side	NN
cord-007084-4niom5mw	178	31	-	-	HYPH
cord-007084-4niom5mw	178	32	chain	chain	NN
cord-007084-4niom5mw	178	33	cleavage	cleavage	NN
cord-007084-4niom5mw	178	34	activity	activity	NN
cord-007084-4niom5mw	178	35	.	.	.
cord-007084-4niom5mw	179	1	The	the	DT
cord-007084-4niom5mw	179	2	ability	ability	NN
cord-007084-4niom5mw	179	3	of	of	IN
cord-007084-4niom5mw	179	4	isolated	isolate	VBN
cord-007084-4niom5mw	179	5	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	179	6	cells	cell	NNS
cord-007084-4niom5mw	179	7	to	to	TO
cord-007084-4niom5mw	179	8	respond	respond	VB
cord-007084-4niom5mw	179	9	to	to	IN
cord-007084-4niom5mw	179	10	ACTH	ACTH	NNP
cord-007084-4niom5mw	179	11	declines	decline	NNS
cord-007084-4niom5mw	179	12	with	with	IN
cord-007084-4niom5mw	179	13	advancing	advance	VBG
cord-007084-4niom5mw	179	14	age	age	NN
cord-007084-4niom5mw	179	15	(	(	-LRB-
cord-007084-4niom5mw	179	16	1	1	CD
cord-007084-4niom5mw	179	17	,	,	,
cord-007084-4niom5mw	179	18	36	36	CD
cord-007084-4niom5mw	179	19	)	)	-RRB-
cord-007084-4niom5mw	179	20	.	.	.
cord-007084-4niom5mw	180	1	We	-PRON-	PRP
cord-007084-4niom5mw	180	2	have	have	VBP
cord-007084-4niom5mw	180	3	shown	show	VBN
cord-007084-4niom5mw	180	4	previously	previously	RB
cord-007084-4niom5mw	180	5	that	that	IN
cord-007084-4niom5mw	180	6	this	this	DT
cord-007084-4niom5mw	180	7	aging	age	VBG
cord-007084-4niom5mw	180	8	defect	defect	NN
cord-007084-4niom5mw	180	9	lies	lie	VBZ
cord-007084-4niom5mw	180	10	distal	distal	JJ
cord-007084-4niom5mw	180	11	to	to	IN
cord-007084-4niom5mw	180	12	both	both	DT
cord-007084-4niom5mw	180	13	binding	binding	NN
cord-007084-4niom5mw	180	14	of	of	IN
cord-007084-4niom5mw	180	15	ACTH	ACTH	NNP
cord-007084-4niom5mw	180	16	to	to	IN
cord-007084-4niom5mw	180	17	its	-PRON-	PRP$
cord-007084-4niom5mw	180	18	receptor	receptor	NN
cord-007084-4niom5mw	180	19	and	and	CC
cord-007084-4niom5mw	180	20	the	the	DT
cord-007084-4niom5mw	180	21	consequent	consequent	JJ
cord-007084-4niom5mw	180	22	production	production	NN
cord-007084-4niom5mw	180	23	of	of	IN
cord-007084-4niom5mw	180	24	its	-PRON-	PRP$
cord-007084-4niom5mw	180	25	secondary	secondary	JJ
cord-007084-4niom5mw	180	26	messenger	messenger	NN
cord-007084-4niom5mw	180	27	cAMP	camp	NN
cord-007084-4niom5mw	180	28	(	(	-LRB-
cord-007084-4niom5mw	180	29	1	1	CD
cord-007084-4niom5mw	180	30	)	)	-RRB-
cord-007084-4niom5mw	180	31	.	.	.
cord-007084-4niom5mw	181	1	In	in	IN
cord-007084-4niom5mw	181	2	the	the	DT
cord-007084-4niom5mw	181	3	present	present	JJ
cord-007084-4niom5mw	181	4	studies	study	NNS
cord-007084-4niom5mw	181	5	the	the	DT
cord-007084-4niom5mw	181	6	possible	possible	JJ
cord-007084-4niom5mw	181	7	relationship	relationship	NN
cord-007084-4niom5mw	181	8	between	between	IN
cord-007084-4niom5mw	181	9	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	181	10	enzyme	enzyme	NN
cord-007084-4niom5mw	181	11	activities	activity	NNS
cord-007084-4niom5mw	181	12	and	and	CC
cord-007084-4niom5mw	181	13	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	181	14	in	in	IN
cord-007084-4niom5mw	181	15	rat	rat	NN
cord-007084-4niom5mw	181	16	adrenals	adrenal	NNS
cord-007084-4niom5mw	181	17	during	during	IN
cord-007084-4niom5mw	181	18	aging	age	VBG
cord-007084-4niom5mw	181	19	was	be	VBD
cord-007084-4niom5mw	181	20	explored	explore	VBN
cord-007084-4niom5mw	181	21	.	.	.
cord-007084-4niom5mw	182	1	Accordingly	accordingly	RB
cord-007084-4niom5mw	182	2	,	,	,
cord-007084-4niom5mw	182	3	we	-PRON-	PRP
cord-007084-4niom5mw	182	4	measured	measure	VBD
cord-007084-4niom5mw	182	5	cholesterol	cholesterol	NN
cord-007084-4niom5mw	182	6	side	side	NN
cord-007084-4niom5mw	182	7	-	-	HYPH
cord-007084-4niom5mw	182	8	chain	chain	NN
cord-007084-4niom5mw	182	9	cleavage	cleavage	NN
cord-007084-4niom5mw	182	10	,	,	,
cord-007084-4niom5mw	182	11	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	182	12	,	,	,
cord-007084-4niom5mw	182	13	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	182	14	,	,	,
cord-007084-4niom5mw	182	15	11/3-hydroxylase	11/3-hydroxylase	CD
cord-007084-4niom5mw	182	16	activities	activity	NNS
cord-007084-4niom5mw	182	17	,	,	,
cord-007084-4niom5mw	182	18	and	and	CC
cord-007084-4niom5mw	182	19	cytochrome	cytochrome	JJ
cord-007084-4niom5mw	182	20	P450	p450	JJ
cord-007084-4niom5mw	182	21	contents	content	NNS
cord-007084-4niom5mw	182	22	in	in	IN
cord-007084-4niom5mw	182	23	appropriate	appropriate	JJ
cord-007084-4niom5mw	182	24	mitochondrial	mitochondrial	NN
cord-007084-4niom5mw	182	25	and	and	CC
cord-007084-4niom5mw	182	26	microsomal	microsomal	JJ
cord-007084-4niom5mw	182	27	fractions	fraction	NNS
cord-007084-4niom5mw	182	28	of	of	IN
cord-007084-4niom5mw	182	29	adrenals	adrenal	NNS
cord-007084-4niom5mw	182	30	from	from	IN
cord-007084-4niom5mw	182	31	2-	2-	CD
cord-007084-4niom5mw	182	32	,	,	,
cord-007084-4niom5mw	182	33	12-	12-	NNP
cord-007084-4niom5mw	182	34	,	,	,
cord-007084-4niom5mw	182	35	and	and	CC
cord-007084-4niom5mw	182	36	18-month	18-month	JJ
cord-007084-4niom5mw	182	37	-	-	HYPH
cord-007084-4niom5mw	182	38	old	old	JJ
cord-007084-4niom5mw	182	39	rats	rat	NNS
cord-007084-4niom5mw	182	40	.	.	.
cord-007084-4niom5mw	183	1	An	an	DT
cord-007084-4niom5mw	183	2	unexpected	unexpected	JJ
cord-007084-4niom5mw	183	3	finding	finding	NN
cord-007084-4niom5mw	183	4	was	be	VBD
cord-007084-4niom5mw	183	5	that	that	IN
cord-007084-4niom5mw	183	6	cholesterol	cholesterol	NN
cord-007084-4niom5mw	183	7	side	side	NN
cord-007084-4niom5mw	183	8	-	-	HYPH
cord-007084-4niom5mw	183	9	chain	chain	NN
cord-007084-4niom5mw	183	10	cleavage	cleavage	NN
cord-007084-4niom5mw	183	11	activity	activity	NN
cord-007084-4niom5mw	183	12	showed	show	VBD
cord-007084-4niom5mw	183	13	a	a	DT
cord-007084-4niom5mw	183	14	progressive	progressive	JJ
cord-007084-4niom5mw	183	15	increase	increase	NN
cord-007084-4niom5mw	183	16	with	with	IN
cord-007084-4niom5mw	183	17	advancing	advance	VBG
cord-007084-4niom5mw	183	18	age	age	NN
cord-007084-4niom5mw	183	19	.	.	.
cord-007084-4niom5mw	184	1	A	a	DT
cord-007084-4niom5mw	184	2	slight	slight	JJ
cord-007084-4niom5mw	184	3	but	but	CC
cord-007084-4niom5mw	184	4	significant	significant	JJ
cord-007084-4niom5mw	184	5	increase	increase	NN
cord-007084-4niom5mw	184	6	in	in	IN
cord-007084-4niom5mw	184	7	the	the	DT
cord-007084-4niom5mw	184	8	activity	activity	NN
cord-007084-4niom5mw	184	9	of	of	IN
cord-007084-4niom5mw	184	10	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	184	11	was	be	VBD
cord-007084-4niom5mw	184	12	also	also	RB
cord-007084-4niom5mw	184	13	noted	note	VBN
cord-007084-4niom5mw	184	14	in	in	IN
cord-007084-4niom5mw	184	15	adrenal	adrenal	JJ
cord-007084-4niom5mw	184	16	microsomal	microsomal	NNP
cord-007084-4niom5mw	184	17	fractions	fraction	NNS
cord-007084-4niom5mw	184	18	from	from	IN
cord-007084-4niom5mw	184	19	senescent	senescent	JJ
cord-007084-4niom5mw	184	20	rats	rat	NNS
cord-007084-4niom5mw	184	21	.	.	.
cord-007084-4niom5mw	185	1	In	in	IN
cord-007084-4niom5mw	185	2	contrast	contrast	NN
cord-007084-4niom5mw	185	3	,	,	,
cord-007084-4niom5mw	185	4	activities	activity	NNS
cord-007084-4niom5mw	185	5	of	of	IN
cord-007084-4niom5mw	185	6	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	185	7	and	and	CC
cord-007084-4niom5mw	185	8	110hydroxylase	110hydroxylase	NNP
cord-007084-4niom5mw	185	9	were	be	VBD
cord-007084-4niom5mw	185	10	insensitive	insensitive	JJ
cord-007084-4niom5mw	185	11	to	to	IN
cord-007084-4niom5mw	185	12	the	the	DT
cord-007084-4niom5mw	185	13	aging	age	VBG
cord-007084-4niom5mw	185	14	process	process	NN
cord-007084-4niom5mw	185	15	.	.	.
cord-007084-4niom5mw	186	1	Interestingly	interestingly	RB
cord-007084-4niom5mw	186	2	,	,	,
cord-007084-4niom5mw	186	3	the	the	DT
cord-007084-4niom5mw	186	4	current	current	JJ
cord-007084-4niom5mw	186	5	results	result	NNS
cord-007084-4niom5mw	186	6	have	have	VBP
cord-007084-4niom5mw	186	7	clearly	clearly	RB
cord-007084-4niom5mw	186	8	indicated	indicate	VBN
cord-007084-4niom5mw	186	9	that	that	IN
cord-007084-4niom5mw	186	10	adrenal	adrenal	JJ
cord-007084-4niom5mw	186	11	side	side	NN
cord-007084-4niom5mw	186	12	-	-	HYPH
cord-007084-4niom5mw	186	13	chain	chain	NN
cord-007084-4niom5mw	186	14	cleavage	cleavage	NN
cord-007084-4niom5mw	186	15	enzyme	enzyme	NN
cord-007084-4niom5mw	186	16	activity	activity	NN
cord-007084-4niom5mw	186	17	increased	increase	VBD
cord-007084-4niom5mw	186	18	at	at	IN
cord-007084-4niom5mw	186	19	a	a	DT
cord-007084-4niom5mw	186	20	time	time	NN
cord-007084-4niom5mw	186	21	when	when	WRB
cord-007084-4niom5mw	186	22	ACTH	ACTH	NNP
cord-007084-4niom5mw	186	23	-	-	HYPH
cord-007084-4niom5mw	186	24	induced	induce	VBN
cord-007084-4niom5mw	186	25	cellular	cellular	JJ
cord-007084-4niom5mw	186	26	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	186	27	has	have	VBZ
cord-007084-4niom5mw	186	28	been	be	VBN
cord-007084-4niom5mw	186	29	more	more	JJR
cord-007084-4niom5mw	186	30	than	than	IN
cord-007084-4niom5mw	186	31	60	60	CD
cord-007084-4niom5mw	186	32	%	%	NN
cord-007084-4niom5mw	186	33	depressed	depressed	JJ
cord-007084-4niom5mw	186	34	(	(	-LRB-
cord-007084-4niom5mw	186	35	1	1	CD
cord-007084-4niom5mw	186	36	,	,	,
cord-007084-4niom5mw	186	37	36	36	CD
cord-007084-4niom5mw	186	38	)	)	-RRB-
cord-007084-4niom5mw	186	39	.	.	.
cord-007084-4niom5mw	187	1	Several	several	JJ
cord-007084-4niom5mw	187	2	mechanisms	mechanism	NNS
cord-007084-4niom5mw	187	3	might	may	MD
cord-007084-4niom5mw	187	4	account	account	VB
cord-007084-4niom5mw	187	5	for	for	IN
cord-007084-4niom5mw	187	6	the	the	DT
cord-007084-4niom5mw	187	7	stimulatory	stimulatory	JJ
cord-007084-4niom5mw	187	8	effect	effect	NN
cord-007084-4niom5mw	187	9	of	of	IN
cord-007084-4niom5mw	187	10	aging	age	VBG
cord-007084-4niom5mw	187	11	on	on	IN
cord-007084-4niom5mw	187	12	cholesterol	cholesterol	NN
cord-007084-4niom5mw	187	13	side	side	NN
cord-007084-4niom5mw	187	14	-	-	HYPH
cord-007084-4niom5mw	187	15	chain	chain	NN
cord-007084-4niom5mw	187	16	cleavage	cleavage	NN
cord-007084-4niom5mw	187	17	activity	activity	NN
cord-007084-4niom5mw	187	18	.	.	.
cord-007084-4niom5mw	188	1	One	one	CD
cord-007084-4niom5mw	188	2	possibility	possibility	NN
cord-007084-4niom5mw	188	3	is	be	VBZ
cord-007084-4niom5mw	188	4	an	an	DT
cord-007084-4niom5mw	188	5	augmentation	augmentation	NN
cord-007084-4niom5mw	188	6	of	of	IN
cord-007084-4niom5mw	188	7	enzyme	enzyme	NN
cord-007084-4niom5mw	188	8	synthesis	synthesis	NN
cord-007084-4niom5mw	188	9	.	.	.
cord-007084-4niom5mw	189	1	In	in	IN
cord-007084-4niom5mw	189	2	addition	addition	NN
cord-007084-4niom5mw	189	3	,	,	,
cord-007084-4niom5mw	189	4	if	if	IN
cord-007084-4niom5mw	189	5	degradation	degradation	NN
cord-007084-4niom5mw	189	6	of	of	IN
cord-007084-4niom5mw	189	7	cholesterol	cholesterol	NN
cord-007084-4niom5mw	189	8	side	side	NN
cord-007084-4niom5mw	189	9	-	-	HYPH
cord-007084-4niom5mw	189	10	chain	chain	NN
cord-007084-4niom5mw	189	11	cleavage	cleavage	NN
cord-007084-4niom5mw	189	12	enzyme	enzyme	NN
cord-007084-4niom5mw	189	13	protein	protein	NN
cord-007084-4niom5mw	189	14	were	be	VBD
cord-007084-4niom5mw	189	15	to	to	TO
cord-007084-4niom5mw	189	16	proceed	proceed	VB
cord-007084-4niom5mw	189	17	at	at	IN
cord-007084-4niom5mw	189	18	a	a	DT
cord-007084-4niom5mw	189	19	lower	low	JJR
cord-007084-4niom5mw	189	20	rate	rate	NN
cord-007084-4niom5mw	189	21	than	than	IN
cord-007084-4niom5mw	189	22	in	in	IN
cord-007084-4niom5mw	189	23	young	young	JJ
cord-007084-4niom5mw	189	24	rats	rat	NNS
cord-007084-4niom5mw	189	25	,	,	,
cord-007084-4niom5mw	189	26	the	the	DT
cord-007084-4niom5mw	189	27	levels	level	NNS
cord-007084-4niom5mw	189	28	of	of	IN
cord-007084-4niom5mw	189	29	this	this	DT
cord-007084-4niom5mw	189	30	enzyme	enzyme	NN
cord-007084-4niom5mw	189	31	would	would	MD
cord-007084-4niom5mw	189	32	be	be	VB
cord-007084-4niom5mw	189	33	expected	expect	VBN
cord-007084-4niom5mw	189	34	to	to	TO
cord-007084-4niom5mw	189	35	be	be	VB
cord-007084-4niom5mw	189	36	higher	high	JJR
cord-007084-4niom5mw	189	37	,	,	,
cord-007084-4niom5mw	189	38	since	since	IN
cord-007084-4niom5mw	189	39	the	the	DT
cord-007084-4niom5mw	189	40	steady	steady	JJ
cord-007084-4niom5mw	189	41	state	state	NN
cord-007084-4niom5mw	189	42	level	level	NN
cord-007084-4niom5mw	189	43	of	of	IN
cord-007084-4niom5mw	189	44	any	any	DT
cord-007084-4niom5mw	189	45	given	give	VBN
cord-007084-4niom5mw	189	46	protein	protein	NN
cord-007084-4niom5mw	189	47	is	be	VBZ
cord-007084-4niom5mw	189	48	achieved	achieve	VBN
cord-007084-4niom5mw	189	49	by	by	IN
cord-007084-4niom5mw	189	50	its	-PRON-	PRP$
cord-007084-4niom5mw	189	51	relative	relative	JJ
cord-007084-4niom5mw	189	52	rates	rate	NNS
cord-007084-4niom5mw	189	53	of	of	IN
cord-007084-4niom5mw	189	54	synthesis	synthesis	NN
cord-007084-4niom5mw	189	55	and	and	CC
cord-007084-4niom5mw	189	56	degradation	degradation	NN
cord-007084-4niom5mw	189	57	.	.	.
cord-007084-4niom5mw	190	1	A	a	DT
cord-007084-4niom5mw	190	2	second	second	JJ
cord-007084-4niom5mw	190	3	possibility	possibility	NN
cord-007084-4niom5mw	190	4	may	may	MD
cord-007084-4niom5mw	190	5	be	be	VB
cord-007084-4niom5mw	190	6	that	that	IN
cord-007084-4niom5mw	190	7	an	an	DT
cord-007084-4niom5mw	190	8	increased	increase	VBN
cord-007084-4niom5mw	190	9	activity	activity	NN
cord-007084-4niom5mw	190	10	represents	represent	VBZ
cord-007084-4niom5mw	190	11	cellular	cellular	JJ
cord-007084-4niom5mw	190	12	adaptive	adaptive	JJ
cord-007084-4niom5mw	190	13	changes	change	NNS
cord-007084-4niom5mw	190	14	to	to	TO
cord-007084-4niom5mw	190	15	deal	deal	VB
cord-007084-4niom5mw	190	16	with	with	IN
cord-007084-4niom5mw	190	17	the	the	DT
cord-007084-4niom5mw	190	18	diminished	diminished	JJ
cord-007084-4niom5mw	190	19	capacity	capacity	NN
cord-007084-4niom5mw	190	20	of	of	IN
cord-007084-4niom5mw	190	21	the	the	DT
cord-007084-4niom5mw	190	22	adrenal	adrenal	JJ
cord-007084-4niom5mw	190	23	gland	gland	NN
cord-007084-4niom5mw	190	24	to	to	TO
cord-007084-4niom5mw	190	25	mobilize	mobilize	VB
cord-007084-4niom5mw	190	26	and	and	CC
cord-007084-4niom5mw	190	27	use	use	VB
cord-007084-4niom5mw	190	28	cholesterol	cholesterol	NN
cord-007084-4niom5mw	190	29	esters	ester	NNS
cord-007084-4niom5mw	190	30	for	for	IN
cord-007084-4niom5mw	190	31	steroidogenesis	steroidogenesis	NNP
cord-007084-4niom5mw	190	32	.	.	.
cord-007084-4niom5mw	191	1	Indeed	indeed	RB
cord-007084-4niom5mw	191	2	,	,	,
cord-007084-4niom5mw	191	3	we	-PRON-	PRP
cord-007084-4niom5mw	191	4	have	have	VBP
cord-007084-4niom5mw	191	5	recently	recently	RB
cord-007084-4niom5mw	191	6	shown	show	VBN
cord-007084-4niom5mw	191	7	that	that	IN
cord-007084-4niom5mw	191	8	cholesterol	cholesterol	NN
cord-007084-4niom5mw	191	9	ester	ester	NN
cord-007084-4niom5mw	191	10	content	content	NN
cord-007084-4niom5mw	191	11	increases	increase	NNS
cord-007084-4niom5mw	191	12	with	with	IN
cord-007084-4niom5mw	191	13	age	age	NN
cord-007084-4niom5mw	191	14	and	and	CC
cord-007084-4niom5mw	191	15	that	that	IN
cord-007084-4niom5mw	191	16	this	this	DT
cord-007084-4niom5mw	191	17	defect	defect	NN
cord-007084-4niom5mw	191	18	was	be	VBD
cord-007084-4niom5mw	191	19	related	relate	VBN
cord-007084-4niom5mw	191	20	to	to	IN
cord-007084-4niom5mw	191	21	specific	specific	JJ
cord-007084-4niom5mw	191	22	changes	change	NNS
cord-007084-4niom5mw	191	23	in	in	IN
cord-007084-4niom5mw	191	24	neutral	neutral	JJ
cord-007084-4niom5mw	191	25	cholesterol	cholesterol	NN
cord-007084-4niom5mw	191	26	esterase	esterase	NN
cord-007084-4niom5mw	191	27	(	(	-LRB-
cord-007084-4niom5mw	191	28	Popplewell	Popplewell	NNP
cord-007084-4niom5mw	191	29	,	,	,
cord-007084-4niom5mw	191	30	P.	P.	NNP
cord-007084-4niom5mw	191	31	Y.	Y.	NNP
cord-007084-4niom5mw	191	32	,	,	,
cord-007084-4niom5mw	191	33	and	and	CC
cord-007084-4niom5mw	191	34	S.	S.	NNP
cord-007084-4niom5mw	191	35	Azhar	Azhar	NNP
cord-007084-4niom5mw	191	36	,	,	,
cord-007084-4niom5mw	191	37	submitted	submit	VBD
cord-007084-4niom5mw	191	38	)	)	-RRB-
cord-007084-4niom5mw	191	39	.	.	.
cord-007084-4niom5mw	192	1	Thus	thus	RB
cord-007084-4niom5mw	192	2	,	,	,
cord-007084-4niom5mw	192	3	an	an	DT
cord-007084-4niom5mw	192	4	increase	increase	NN
cord-007084-4niom5mw	192	5	in	in	IN
cord-007084-4niom5mw	192	6	cholesterol	cholesterol	NN
cord-007084-4niom5mw	192	7	side	side	NN
cord-007084-4niom5mw	192	8	-	-	HYPH
cord-007084-4niom5mw	192	9	chain	chain	NN
cord-007084-4niom5mw	192	10	cleavage	cleavage	NN
cord-007084-4niom5mw	192	11	activity	activity	NN
cord-007084-4niom5mw	192	12	can	can	MD
cord-007084-4niom5mw	192	13	be	be	VB
cord-007084-4niom5mw	192	14	viewed	view	VBN
cord-007084-4niom5mw	192	15	as	as	IN
cord-007084-4niom5mw	192	16	a	a	DT
cord-007084-4niom5mw	192	17	compensation	compensation	NN
cord-007084-4niom5mw	192	18	on	on	IN
cord-007084-4niom5mw	192	19	the	the	DT
cord-007084-4niom5mw	192	20	part	part	NN
cord-007084-4niom5mw	192	21	of	of	IN
cord-007084-4niom5mw	192	22	the	the	DT
cord-007084-4niom5mw	192	23	enzyme	enzyme	NN
cord-007084-4niom5mw	192	24	to	to	IN
cord-007084-4niom5mw	192	25	the	the	DT
cord-007084-4niom5mw	192	26	elevated	elevated	JJ
cord-007084-4niom5mw	192	27	cholesterol	cholesterol	NN
cord-007084-4niom5mw	192	28	esters	ester	NNS
cord-007084-4niom5mw	192	29	levels	level	NNS
cord-007084-4niom5mw	192	30	.	.	.
cord-007084-4niom5mw	193	1	That	that	RB
cord-007084-4niom5mw	193	2	is	is	RB
cord-007084-4niom5mw	193	3	,	,	,
cord-007084-4niom5mw	193	4	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	193	5	side	side	NN
cord-007084-4niom5mw	193	6	-	-	HYPH
cord-007084-4niom5mw	193	7	chain	chain	NN
cord-007084-4niom5mw	193	8	cleavage	cleavage	NN
cord-007084-4niom5mw	193	9	enzymes	enzyme	NNS
cord-007084-4niom5mw	193	10	increase	increase	VBP
cord-007084-4niom5mw	193	11	in	in	IN
cord-007084-4niom5mw	193	12	activity	activity	NN
cord-007084-4niom5mw	193	13	in	in	IN
cord-007084-4niom5mw	193	14	order	order	NN
cord-007084-4niom5mw	193	15	to	to	TO
cord-007084-4niom5mw	193	16	effectively	effectively	RB
cord-007084-4niom5mw	193	17	use	use	VB
cord-007084-4niom5mw	193	18	that	that	DT
cord-007084-4niom5mw	193	19	cholesterol	cholesterol	NN
cord-007084-4niom5mw	193	20	which	which	WDT
cord-007084-4niom5mw	193	21	becomes	become	VBZ
cord-007084-4niom5mw	193	22	available	available	JJ
cord-007084-4niom5mw	193	23	from	from	IN
cord-007084-4niom5mw	193	24	the	the	DT
cord-007084-4niom5mw	193	25	stored	store	VBN
cord-007084-4niom5mw	193	26	cholesterol	cholesterol	NN
cord-007084-4niom5mw	193	27	ester	ester	NN
cord-007084-4niom5mw	193	28	.	.	.
cord-007084-4niom5mw	194	1	However	however	RB
cord-007084-4niom5mw	194	2	,	,	,
cord-007084-4niom5mw	194	3	the	the	DT
cord-007084-4niom5mw	194	4	fact	fact	NN
cord-007084-4niom5mw	194	5	that	that	IN
cord-007084-4niom5mw	194	6	the	the	DT
cord-007084-4niom5mw	194	7	adrenal	adrenal	JJ
cord-007084-4niom5mw	194	8	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	194	9	response	response	NN
cord-007084-4niom5mw	194	10	is	be	VBZ
cord-007084-4niom5mw	194	11	still	still	RB
cord-007084-4niom5mw	194	12	blunted	blunt	VBN
cord-007084-4niom5mw	194	13	in	in	IN
cord-007084-4niom5mw	194	14	senescent	senescent	JJ
cord-007084-4niom5mw	194	15	rats	rat	NNS
cord-007084-4niom5mw	194	16	demonstrates	demonstrate	VBZ
cord-007084-4niom5mw	194	17	this	this	DT
cord-007084-4niom5mw	194	18	to	to	TO
cord-007084-4niom5mw	194	19	be	be	VB
cord-007084-4niom5mw	194	20	a	a	DT
cord-007084-4niom5mw	194	21	partially	partially	RB
cord-007084-4niom5mw	194	22	successful	successful	JJ
cord-007084-4niom5mw	194	23	compensation	compensation	NN
cord-007084-4niom5mw	194	24	.	.	.
cord-007084-4niom5mw	195	1	Another	another	DT
cord-007084-4niom5mw	195	2	possibility	possibility	NN
cord-007084-4niom5mw	195	3	of	of	IN
cord-007084-4niom5mw	195	4	equal	equal	JJ
cord-007084-4niom5mw	195	5	importance	importance	NN
cord-007084-4niom5mw	195	6	is	be	VBZ
cord-007084-4niom5mw	195	7	that	that	IN
cord-007084-4niom5mw	195	8	the	the	DT
cord-007084-4niom5mw	195	9	observed	observed	JJ
cord-007084-4niom5mw	195	10	increase	increase	NN
cord-007084-4niom5mw	195	11	in	in	IN
cord-007084-4niom5mw	195	12	cholesterol	cholesterol	NN
cord-007084-4niom5mw	195	13	side	side	NN
cord-007084-4niom5mw	195	14	-	-	HYPH
cord-007084-4niom5mw	195	15	chain	chain	NN
cord-007084-4niom5mw	195	16	activity	activity	NN
cord-007084-4niom5mw	195	17	may	may	MD
cord-007084-4niom5mw	195	18	be	be	VB
cord-007084-4niom5mw	195	19	in	in	IN
cord-007084-4niom5mw	195	20	response	response	NN
cord-007084-4niom5mw	195	21	to	to	IN
cord-007084-4niom5mw	195	22	vastly	vastly	RB
cord-007084-4niom5mw	195	23	elevated	elevated	JJ
cord-007084-4niom5mw	195	24	levels	level	NNS
cord-007084-4niom5mw	195	25	of	of	IN
cord-007084-4niom5mw	195	26	plasma	plasma	NN
cord-007084-4niom5mw	195	27	ACTH	ACTH	NNP
cord-007084-4niom5mw	195	28	,	,	,
cord-007084-4niom5mw	195	29	previously	previously	RB
cord-007084-4niom5mw	195	30	reported	report	VBN
cord-007084-4niom5mw	195	31	in	in	IN
cord-007084-4niom5mw	195	32	senescent	senescent	JJ
cord-007084-4niom5mw	195	33	rats	rat	NNS
cord-007084-4niom5mw	195	34	(	(	-LRB-
cord-007084-4niom5mw	195	35	37	37	CD
cord-007084-4niom5mw	195	36	)	)	-RRB-
cord-007084-4niom5mw	195	37	.	.	.
cord-007084-4niom5mw	196	1	This	this	DT
cord-007084-4niom5mw	196	2	hyperstimulation	hyperstimulation	NN
cord-007084-4niom5mw	196	3	hypothesis	hypothesis	NN
cord-007084-4niom5mw	196	4	is	be	VBZ
cord-007084-4niom5mw	196	5	supported	support	VBN
cord-007084-4niom5mw	196	6	by	by	IN
cord-007084-4niom5mw	196	7	the	the	DT
cord-007084-4niom5mw	196	8	observations	observation	NNS
cord-007084-4niom5mw	196	9	that	that	WDT
cord-007084-4niom5mw	196	10	the	the	DT
cord-007084-4niom5mw	196	11	cholesterol	cholesterol	NN
cord-007084-4niom5mw	196	12	side	side	NN
cord-007084-4niom5mw	196	13	-	-	HYPH
cord-007084-4niom5mw	196	14	chain	chain	NN
cord-007084-4niom5mw	196	15	cleavage	cleavage	NN
cord-007084-4niom5mw	196	16	step	step	NN
cord-007084-4niom5mw	196	17	is	be	VBZ
cord-007084-4niom5mw	196	18	the	the	DT
cord-007084-4niom5mw	196	19	rate	rate	NN
cord-007084-4niom5mw	196	20	-	-	HYPH
cord-007084-4niom5mw	196	21	limiting	limit	VBG
cord-007084-4niom5mw	196	22	step	step	NN
cord-007084-4niom5mw	196	23	in	in	IN
cord-007084-4niom5mw	196	24	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	196	25	and	and	CC
cord-007084-4niom5mw	196	26	,	,	,
cord-007084-4niom5mw	196	27	as	as	IN
cord-007084-4niom5mw	196	28	such	such	JJ
cord-007084-4niom5mw	196	29	,	,	,
cord-007084-4niom5mw	196	30	activated	activate	VBN
cord-007084-4niom5mw	196	31	/	/	SYM
cord-007084-4niom5mw	196	32	regulated	regulate	VBN
cord-007084-4niom5mw	196	33	by	by	IN
cord-007084-4niom5mw	196	34	ACTH	ACTH	NNP
cord-007084-4niom5mw	196	35	(	(	-LRB-
cord-007084-4niom5mw	196	36	2	2	CD
cord-007084-4niom5mw	196	37	,	,	,
cord-007084-4niom5mw	196	38	4	4	CD
cord-007084-4niom5mw	196	39	,	,	,
cord-007084-4niom5mw	196	40	5	5	CD
cord-007084-4niom5mw	196	41	)	)	-RRB-
cord-007084-4niom5mw	196	42	.	.	.
cord-007084-4niom5mw	197	1	Finally	finally	RB
cord-007084-4niom5mw	197	2	,	,	,
cord-007084-4niom5mw	197	3	evidence	evidence	NN
cord-007084-4niom5mw	197	4	has	have	VBZ
cord-007084-4niom5mw	197	5	recently	recently	RB
cord-007084-4niom5mw	197	6	been	be	VBN
cord-007084-4niom5mw	197	7	presented	present	VBN
cord-007084-4niom5mw	197	8	to	to	TO
cord-007084-4niom5mw	197	9	support	support	VB
cord-007084-4niom5mw	197	10	the	the	DT
cord-007084-4niom5mw	197	11	idea	idea	NN
cord-007084-4niom5mw	197	12	that	that	IN
cord-007084-4niom5mw	197	13	adrenal	adrenal	JJ
cord-007084-4niom5mw	197	14	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	197	15	contain	contain	VBP
cord-007084-4niom5mw	197	16	more	more	JJR
cord-007084-4niom5mw	197	17	than	than	IN
cord-007084-4niom5mw	197	18	one	one	CD
cord-007084-4niom5mw	197	19	cholesterol	cholesterol	NN
cord-007084-4niom5mw	197	20	side	side	NN
cord-007084-4niom5mw	197	21	-	-	HYPH
cord-007084-4niom5mw	197	22	chain	chain	NN
cord-007084-4niom5mw	197	23	cleavage	cleavage	NN
cord-007084-4niom5mw	197	24	system	system	NN
cord-007084-4niom5mw	197	25	(	(	-LRB-
cord-007084-4niom5mw	197	26	38	38	CD
cord-007084-4niom5mw	197	27	)	)	-RRB-
cord-007084-4niom5mw	197	28	(	(	-LRB-
cord-007084-4niom5mw	197	29	39	39	CD
cord-007084-4niom5mw	197	30	)	)	-RRB-
cord-007084-4niom5mw	197	31	(	(	-LRB-
cord-007084-4niom5mw	197	32	40	40	CD
cord-007084-4niom5mw	197	33	)	)	-RRB-
cord-007084-4niom5mw	197	34	.	.	.
cord-007084-4niom5mw	198	1	Thus	thus	RB
cord-007084-4niom5mw	198	2	,	,	,
cord-007084-4niom5mw	198	3	it	-PRON-	PRP
cord-007084-4niom5mw	198	4	is	be	VBZ
cord-007084-4niom5mw	198	5	conceivable	conceivable	JJ
cord-007084-4niom5mw	198	6	that	that	IN
cord-007084-4niom5mw	198	7	elevated	elevated	JJ
cord-007084-4niom5mw	198	8	levels	level	NNS
cord-007084-4niom5mw	198	9	represent	represent	VBP
cord-007084-4niom5mw	198	10	stimulation	stimulation	NN
cord-007084-4niom5mw	198	11	of	of	IN
cord-007084-4niom5mw	198	12	only	only	RB
cord-007084-4niom5mw	198	13	one	one	CD
cord-007084-4niom5mw	198	14	isoenzymic	isoenzymic	JJ
cord-007084-4niom5mw	198	15	form	form	NN
cord-007084-4niom5mw	198	16	which	which	WDT
cord-007084-4niom5mw	198	17	may	may	MD
cord-007084-4niom5mw	198	18	or	or	CC
cord-007084-4niom5mw	198	19	may	may	MD
cord-007084-4niom5mw	198	20	not	not	RB
cord-007084-4niom5mw	198	21	actively	actively	RB
cord-007084-4niom5mw	198	22	participate	participate	VB
cord-007084-4niom5mw	198	23	in	in	IN
cord-007084-4niom5mw	198	24	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	198	25	under	under	IN
cord-007084-4niom5mw	198	26	in	in	IN
cord-007084-4niom5mw	198	27	vivo	vivo	NN
cord-007084-4niom5mw	198	28	situations	situation	NNS
cord-007084-4niom5mw	198	29	.	.	.
cord-007084-4niom5mw	199	1	Obviously	obviously	RB
cord-007084-4niom5mw	199	2	more	more	RBR
cord-007084-4niom5mw	199	3	rigorous	rigorous	JJ
cord-007084-4niom5mw	199	4	experimental	experimental	JJ
cord-007084-4niom5mw	199	5	approaches	approach	NNS
cord-007084-4niom5mw	199	6	are	be	VBP
cord-007084-4niom5mw	199	7	needed	need	VBN
cord-007084-4niom5mw	199	8	to	to	TO
cord-007084-4niom5mw	199	9	sort	sort	VB
cord-007084-4niom5mw	199	10	out	out	RP
cord-007084-4niom5mw	199	11	these	these	DT
cord-007084-4niom5mw	199	12	various	various	JJ
cord-007084-4niom5mw	199	13	possibilities	possibility	NNS
cord-007084-4niom5mw	199	14	.	.	.
cord-007084-4niom5mw	200	1	Such	such	JJ
cord-007084-4niom5mw	200	2	investigations	investigation	NNS
cord-007084-4niom5mw	200	3	are	be	VBP
cord-007084-4niom5mw	200	4	currently	currently	RB
cord-007084-4niom5mw	200	5	in	in	IN
cord-007084-4niom5mw	200	6	progress	progress	NN
cord-007084-4niom5mw	200	7	in	in	IN
cord-007084-4niom5mw	200	8	our	-PRON-	PRP$
cord-007084-4niom5mw	200	9	laboratory	laboratory	NN
cord-007084-4niom5mw	200	10	.	.	.
cord-007084-4niom5mw	201	1	We	-PRON-	PRP
cord-007084-4niom5mw	201	2	were	be	VBD
cord-007084-4niom5mw	201	3	unable	unable	JJ
cord-007084-4niom5mw	201	4	to	to	TO
cord-007084-4niom5mw	201	5	document	document	VB
cord-007084-4niom5mw	201	6	any	any	DT
cord-007084-4niom5mw	201	7	age	age	NN
cord-007084-4niom5mw	201	8	-	-	HYPH
cord-007084-4niom5mw	201	9	related	relate	VBN
cord-007084-4niom5mw	201	10	changes	change	NNS
cord-007084-4niom5mw	201	11	in	in	IN
cord-007084-4niom5mw	201	12	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	201	13	cytochrome	cytochrome	NN
cord-007084-4niom5mw	201	14	P450	p450	JJ
cord-007084-4niom5mw	201	15	levels	level	NNS
cord-007084-4niom5mw	201	16	.	.	.
cord-007084-4niom5mw	202	1	These	these	DT
cord-007084-4niom5mw	202	2	results	result	NNS
cord-007084-4niom5mw	202	3	point	point	VBP
cord-007084-4niom5mw	202	4	to	to	IN
cord-007084-4niom5mw	202	5	a	a	DT
cord-007084-4niom5mw	202	6	dissociation	dissociation	NN
cord-007084-4niom5mw	202	7	between	between	IN
cord-007084-4niom5mw	202	8	cytochrome	cytochrome	NN
cord-007084-4niom5mw	202	9	P450	p450	JJ
cord-007084-4niom5mw	202	10	levels	level	NNS
cord-007084-4niom5mw	202	11	and	and	CC
cord-007084-4niom5mw	202	12	cholesterol	cholesterol	NN
cord-007084-4niom5mw	202	13	side	side	NN
cord-007084-4niom5mw	202	14	-	-	HYPH
cord-007084-4niom5mw	202	15	chain	chain	NN
cord-007084-4niom5mw	202	16	cleavage	cleavage	NN
cord-007084-4niom5mw	202	17	enzyme	enzyme	NN
cord-007084-4niom5mw	202	18	activity	activity	NN
cord-007084-4niom5mw	202	19	.	.	.
cord-007084-4niom5mw	203	1	This	this	DT
cord-007084-4niom5mw	203	2	discrepancy	discrepancy	NN
cord-007084-4niom5mw	203	3	could	could	MD
cord-007084-4niom5mw	203	4	be	be	VB
cord-007084-4niom5mw	203	5	attributed	attribute	VBN
cord-007084-4niom5mw	203	6	to	to	IN
cord-007084-4niom5mw	203	7	a	a	DT
cord-007084-4niom5mw	203	8	variation	variation	NN
cord-007084-4niom5mw	203	9	in	in	IN
cord-007084-4niom5mw	203	10	the	the	DT
cord-007084-4niom5mw	203	11	relative	relative	JJ
cord-007084-4niom5mw	203	12	compositions	composition	NNS
cord-007084-4niom5mw	203	13	of	of	IN
cord-007084-4niom5mw	203	14	various	various	JJ
cord-007084-4niom5mw	203	15	forms	form	NNS
cord-007084-4niom5mw	203	16	of	of	IN
cord-007084-4niom5mw	203	17	cytochrome	cytochrome	NN
cord-007084-4niom5mw	203	18	P450	p450	NN
cord-007084-4niom5mw	203	19	in	in	IN
cord-007084-4niom5mw	203	20	total	total	JJ
cord-007084-4niom5mw	203	21	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	203	22	preparations	preparation	NNS
cord-007084-4niom5mw	203	23	from	from	IN
cord-007084-4niom5mw	203	24	young	young	JJ
cord-007084-4niom5mw	203	25	and	and	CC
cord-007084-4niom5mw	203	26	senescent	senescent	JJ
cord-007084-4niom5mw	203	27	rat	rat	NN
cord-007084-4niom5mw	203	28	adrenals	adrenal	NNS
cord-007084-4niom5mw	203	29	(	(	-LRB-
cord-007084-4niom5mw	203	30	41	41	CD
cord-007084-4niom5mw	203	31	,	,	,
cord-007084-4niom5mw	203	32	42	42	CD
cord-007084-4niom5mw	203	33	)	)	-RRB-
cord-007084-4niom5mw	203	34	.	.	.
cord-007084-4niom5mw	204	1	In	in	IN
cord-007084-4niom5mw	204	2	addition	addition	NN
cord-007084-4niom5mw	204	3	,	,	,
cord-007084-4niom5mw	204	4	a	a	DT
cord-007084-4niom5mw	204	5	pool	pool	NN
cord-007084-4niom5mw	204	6	of	of	IN
cord-007084-4niom5mw	204	7	cytochrome	cytochrome	NN
cord-007084-4niom5mw	204	8	P450	p450	NN
cord-007084-4niom5mw	204	9	not	not	RB
cord-007084-4niom5mw	204	10	associated	associate	VBN
cord-007084-4niom5mw	204	11	with	with	IN
cord-007084-4niom5mw	204	12	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	204	13	enzymes	enzyme	NNS
cord-007084-4niom5mw	204	14	(	(	-LRB-
cord-007084-4niom5mw	204	15	i.e.	i.e.	FW
cord-007084-4niom5mw	204	16	cytochrome	cytochrome	JJ
cord-007084-4niom5mw	204	17	P450	p450	NN
cord-007084-4niom5mw	204	18	8CC	8cc	CD
cord-007084-4niom5mw	204	19	or	or	CC
cord-007084-4niom5mw	204	20	cytochrome	cytochrome	NN
cord-007084-4niom5mw	204	21	P450	P450	NNP
cord-007084-4niom5mw	204	22	U/	U/	NNP
cord-007084-4niom5mw	204	23	3	3	CD
cord-007084-4niom5mw	204	24	)	)	-RRB-
cord-007084-4niom5mw	204	25	may	may	MD
cord-007084-4niom5mw	204	26	exist	exist	VB
cord-007084-4niom5mw	204	27	(	(	-LRB-
cord-007084-4niom5mw	204	28	12	12	CD
cord-007084-4niom5mw	204	29	)	)	-RRB-
cord-007084-4niom5mw	204	30	,	,	,
cord-007084-4niom5mw	204	31	which	which	WDT
cord-007084-4niom5mw	204	32	,	,	,
cord-007084-4niom5mw	204	33	in	in	IN
cord-007084-4niom5mw	204	34	turn	turn	NN
cord-007084-4niom5mw	204	35	,	,	,
cord-007084-4niom5mw	204	36	could	could	MD
cord-007084-4niom5mw	204	37	mask	mask	VB
cord-007084-4niom5mw	204	38	a	a	DT
cord-007084-4niom5mw	204	39	real	real	JJ
cord-007084-4niom5mw	204	40	age	age	NN
cord-007084-4niom5mw	204	41	effect	effect	NN
cord-007084-4niom5mw	204	42	on	on	IN
cord-007084-4niom5mw	204	43	specific	specific	JJ
cord-007084-4niom5mw	204	44	cytochrome	cytochrome	NN
cord-007084-4niom5mw	204	45	P450	P450	NNP
cord-007084-4niom5mw	204	46	8CC	8cc	CD
cord-007084-4niom5mw	204	47	.	.	.
cord-007084-4niom5mw	205	1	The	the	DT
cord-007084-4niom5mw	205	2	above	above	JJ
cord-007084-4niom5mw	205	3	hypothesis	hypothesis	NN
cord-007084-4niom5mw	205	4	is	be	VBZ
cord-007084-4niom5mw	205	5	of	of	IN
cord-007084-4niom5mw	205	6	interest	interest	NN
cord-007084-4niom5mw	205	7	in	in	IN
cord-007084-4niom5mw	205	8	view	view	NN
cord-007084-4niom5mw	205	9	of	of	IN
cord-007084-4niom5mw	205	10	the	the	DT
cord-007084-4niom5mw	205	11	previous	previous	JJ
cord-007084-4niom5mw	205	12	finding	finding	NN
cord-007084-4niom5mw	205	13	demonstrating	demonstrate	VBG
cord-007084-4niom5mw	205	14	a	a	DT
cord-007084-4niom5mw	205	15	dissociation	dissociation	NN
cord-007084-4niom5mw	205	16	in	in	IN
cord-007084-4niom5mw	205	17	half	half	RB
cord-007084-4niom5mw	205	18	-	-	HYPH
cord-007084-4niom5mw	205	19	lives	life	NNS
cord-007084-4niom5mw	205	20	of	of	IN
cord-007084-4niom5mw	205	21	21-hydroxylase	21-hydroxylase	CD
cord-007084-4niom5mw	205	22	and	and	CC
cord-007084-4niom5mw	205	23	cytochrome	cytochrome	NN
cord-007084-4niom5mw	205	24	P450	P450	NNPS
cord-007084-4niom5mw	205	25	(	(	-LRB-
cord-007084-4niom5mw	205	26	4.5	4.5	CD
cord-007084-4niom5mw	205	27	vs.	vs.	IN
cord-007084-4niom5mw	205	28	2.9	2.9	CD
cord-007084-4niom5mw	205	29	days	day	NNS
cord-007084-4niom5mw	205	30	)	)	-RRB-
cord-007084-4niom5mw	205	31	in	in	IN
cord-007084-4niom5mw	205	32	rat	rat	NN
cord-007084-4niom5mw	205	33	adrenals	adrenal	NNS
cord-007084-4niom5mw	205	34	after	after	IN
cord-007084-4niom5mw	205	35	hypophysectomy	hypophysectomy	NNP
cord-007084-4niom5mw	205	36	(	(	-LRB-
cord-007084-4niom5mw	205	37	12	12	CD
cord-007084-4niom5mw	205	38	)	)	-RRB-
cord-007084-4niom5mw	205	39	.	.	.
cord-007084-4niom5mw	206	1	Additional	additional	JJ
cord-007084-4niom5mw	206	2	evidence	evidence	NN
cord-007084-4niom5mw	206	3	for	for	IN
cord-007084-4niom5mw	206	4	this	this	DT
cord-007084-4niom5mw	206	5	hypothesis	hypothesis	NN
cord-007084-4niom5mw	206	6	is	be	VBZ
cord-007084-4niom5mw	206	7	the	the	DT
cord-007084-4niom5mw	206	8	recent	recent	JJ
cord-007084-4niom5mw	206	9	finding	finding	NN
cord-007084-4niom5mw	206	10	of	of	IN
cord-007084-4niom5mw	206	11	Naumoff	Naumoff	NNP
cord-007084-4niom5mw	206	12	and	and	CC
cord-007084-4niom5mw	206	13	Stevenson	Stevenson	NNP
cord-007084-4niom5mw	206	14	(	(	-LRB-
cord-007084-4niom5mw	206	15	43	43	CD
cord-007084-4niom5mw	206	16	)	)	-RRB-
cord-007084-4niom5mw	206	17	,	,	,
cord-007084-4niom5mw	206	18	who	who	WP
cord-007084-4niom5mw	206	19	observed	observe	VBD
cord-007084-4niom5mw	206	20	a	a	DT
cord-007084-4niom5mw	206	21	delayed	delay	VBN
cord-007084-4niom5mw	206	22	developmental	developmental	JJ
cord-007084-4niom5mw	206	23	maturation	maturation	NN
cord-007084-4niom5mw	206	24	pattern	pattern	NN
cord-007084-4niom5mw	206	25	for	for	IN
cord-007084-4niom5mw	206	26	cholesterol	cholesterol	NN
cord-007084-4niom5mw	206	27	side	side	NN
cord-007084-4niom5mw	206	28	-	-	HYPH
cord-007084-4niom5mw	206	29	chain	chain	NN
cord-007084-4niom5mw	206	30	activity	activity	NN
cord-007084-4niom5mw	206	31	compared	compare	VBN
cord-007084-4niom5mw	206	32	to	to	IN
cord-007084-4niom5mw	206	33	cytochrome	cytochrome	NN
cord-007084-4niom5mw	206	34	P450	p450	NN
cord-007084-4niom5mw	206	35	in	in	IN
cord-007084-4niom5mw	206	36	rat	rat	NN
cord-007084-4niom5mw	206	37	ovaries	ovary	NNS
cord-007084-4niom5mw	206	38	after	after	IN
cord-007084-4niom5mw	206	39	gonadotropin	gonadotropin	NN
cord-007084-4niom5mw	206	40	treatment	treatment	NN
cord-007084-4niom5mw	206	41	.	.	.
cord-007084-4niom5mw	207	1	In	in	IN
cord-007084-4niom5mw	207	2	view	view	NN
cord-007084-4niom5mw	207	3	of	of	IN
cord-007084-4niom5mw	207	4	these	these	DT
cord-007084-4niom5mw	207	5	observations	observation	NNS
cord-007084-4niom5mw	207	6	,	,	,
cord-007084-4niom5mw	207	7	it	-PRON-	PRP
cord-007084-4niom5mw	207	8	is	be	VBZ
cord-007084-4niom5mw	207	9	not	not	RB
cord-007084-4niom5mw	207	10	unreasonable	unreasonable	JJ
cord-007084-4niom5mw	207	11	to	to	TO
cord-007084-4niom5mw	207	12	speculate	speculate	VB
cord-007084-4niom5mw	207	13	that	that	IN
cord-007084-4niom5mw	207	14	levels	level	NNS
cord-007084-4niom5mw	207	15	of	of	IN
cord-007084-4niom5mw	207	16	cytochrome	cytochrome	NN
cord-007084-4niom5mw	207	17	P450	p450	NN
cord-007084-4niom5mw	207	18	and	and	CC
cord-007084-4niom5mw	207	19	side	side	NN
cord-007084-4niom5mw	207	20	-	-	HYPH
cord-007084-4niom5mw	207	21	chain	chain	NN
cord-007084-4niom5mw	207	22	cleavage	cleavage	NN
cord-007084-4niom5mw	207	23	are	be	VBP
cord-007084-4niom5mw	207	24	modulated	modulate	VBN
cord-007084-4niom5mw	207	25	differentially	differentially	RB
cord-007084-4niom5mw	207	26	as	as	IN
cord-007084-4niom5mw	207	27	rats	rat	NNS
cord-007084-4niom5mw	207	28	grow	grow	VBP
cord-007084-4niom5mw	207	29	old	old	JJ
cord-007084-4niom5mw	207	30	.	.	.
cord-007084-4niom5mw	208	1	Finally	finally	RB
cord-007084-4niom5mw	208	2	,	,	,
cord-007084-4niom5mw	208	3	demonstration	demonstration	NN
cord-007084-4niom5mw	208	4	of	of	IN
cord-007084-4niom5mw	208	5	any	any	DT
cord-007084-4niom5mw	208	6	specific	specific	JJ
cord-007084-4niom5mw	208	7	age	age	NN
cord-007084-4niom5mw	208	8	effect	effect	NN
cord-007084-4niom5mw	208	9	on	on	IN
cord-007084-4niom5mw	208	10	cytochrome	cytochrome	NN
cord-007084-4niom5mw	208	11	P450	P450	NNP
cord-007084-4niom5mw	208	12	8CC	8cc	CD
cord-007084-4niom5mw	208	13	will	will	MD
cord-007084-4niom5mw	208	14	require	require	VB
cord-007084-4niom5mw	208	15	the	the	DT
cord-007084-4niom5mw	208	16	purification	purification	NN
cord-007084-4niom5mw	208	17	of	of	IN
cord-007084-4niom5mw	208	18	a	a	DT
cord-007084-4niom5mw	208	19	side	side	NN
cord-007084-4niom5mw	208	20	-	-	HYPH
cord-007084-4niom5mw	208	21	chain	chain	NN
cord-007084-4niom5mw	208	22	cleavage	cleavage	NN
cord-007084-4niom5mw	208	23	enzyme	enzyme	NN
cord-007084-4niom5mw	208	24	system	system	NN
cord-007084-4niom5mw	208	25	from	from	IN
cord-007084-4niom5mw	208	26	adrenals	adrenal	NNS
cord-007084-4niom5mw	208	27	of	of	IN
cord-007084-4niom5mw	208	28	young	young	JJ
cord-007084-4niom5mw	208	29	and	and	CC
cord-007084-4niom5mw	208	30	old	old	JJ
cord-007084-4niom5mw	208	31	rats	rat	NNS
cord-007084-4niom5mw	208	32	.	.	.
cord-007084-4niom5mw	209	1	Results	result	NNS
cord-007084-4niom5mw	209	2	of	of	IN
cord-007084-4niom5mw	209	3	the	the	DT
cord-007084-4niom5mw	209	4	present	present	JJ
cord-007084-4niom5mw	209	5	study	study	NN
cord-007084-4niom5mw	209	6	also	also	RB
cord-007084-4niom5mw	209	7	suggest	suggest	VBP
cord-007084-4niom5mw	209	8	that	that	IN
cord-007084-4niom5mw	209	9	the	the	DT
cord-007084-4niom5mw	209	10	decline	decline	NN
cord-007084-4niom5mw	209	11	in	in	IN
cord-007084-4niom5mw	209	12	steroidogenesis	steroidogenesis	NNP
cord-007084-4niom5mw	209	13	observed	observe	VBN
cord-007084-4niom5mw	209	14	in	in	IN
cord-007084-4niom5mw	209	15	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	209	16	cells	cell	NNS
cord-007084-4niom5mw	209	17	isolated	isolate	VBN
cord-007084-4niom5mw	209	18	from	from	IN
cord-007084-4niom5mw	209	19	senescent	senescent	JJ
cord-007084-4niom5mw	209	20	rats	rat	NNS
cord-007084-4niom5mw	209	21	is	be	VBZ
cord-007084-4niom5mw	209	22	not	not	RB
cord-007084-4niom5mw	209	23	related	relate	VBN
cord-007084-4niom5mw	209	24	to	to	IN
cord-007084-4niom5mw	209	25	a	a	DT
cord-007084-4niom5mw	209	26	reduction	reduction	NN
cord-007084-4niom5mw	209	27	in	in	IN
cord-007084-4niom5mw	209	28	cholesterol	cholesterol	NN
cord-007084-4niom5mw	209	29	side	side	NN
cord-007084-4niom5mw	209	30	-	-	HYPH
cord-007084-4niom5mw	209	31	chain	chain	NN
cord-007084-4niom5mw	209	32	cleavage	cleavage	NN
cord-007084-4niom5mw	209	33	activity	activity	NN
cord-007084-4niom5mw	209	34	or	or	CC
cord-007084-4niom5mw	209	35	other	other	JJ
cord-007084-4niom5mw	209	36	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	209	37	responses	response	NNS
cord-007084-4niom5mw	209	38	,	,	,
cord-007084-4niom5mw	209	39	as	as	IN
cord-007084-4niom5mw	209	40	measured	measure	VBN
cord-007084-4niom5mw	209	41	in	in	IN
cord-007084-4niom5mw	209	42	vitro	vitro	FW
cord-007084-4niom5mw	209	43	in	in	IN
cord-007084-4niom5mw	209	44	isolated	isolate	VBN
cord-007084-4niom5mw	209	45	subcellular	subcellular	JJ
cord-007084-4niom5mw	209	46	components	component	NNS
cord-007084-4niom5mw	209	47	.	.	.
cord-007084-4niom5mw	210	1	These	these	DT
cord-007084-4niom5mw	210	2	in	in	IN
cord-007084-4niom5mw	210	3	vitro	vitro	FW
cord-007084-4niom5mw	210	4	results	result	NNS
cord-007084-4niom5mw	210	5	do	do	VBP
cord-007084-4niom5mw	210	6	hot	hot	JJ
cord-007084-4niom5mw	210	7	exclude	exclude	VB
cord-007084-4niom5mw	210	8	the	the	DT
cord-007084-4niom5mw	210	9	possibility	possibility	NN
cord-007084-4niom5mw	210	10	,	,	,
cord-007084-4niom5mw	210	11	however	however	RB
cord-007084-4niom5mw	210	12	,	,	,
cord-007084-4niom5mw	210	13	that	that	IN
cord-007084-4niom5mw	210	14	side	side	NN
cord-007084-4niom5mw	210	15	-	-	HYPH
cord-007084-4niom5mw	210	16	chain	chain	NN
cord-007084-4niom5mw	210	17	cleavage	cleavage	NN
cord-007084-4niom5mw	210	18	activity	activity	NN
cord-007084-4niom5mw	210	19	is	be	VBZ
cord-007084-4niom5mw	210	20	reduced	reduce	VBN
cord-007084-4niom5mw	210	21	(	(	-LRB-
cord-007084-4niom5mw	210	22	or	or	CC
cord-007084-4niom5mw	210	23	blunted	blunt	VBN
cord-007084-4niom5mw	210	24	)	)	-RRB-
cord-007084-4niom5mw	210	25	in	in	IN
cord-007084-4niom5mw	210	26	intact	intact	JJ
cord-007084-4niom5mw	210	27	cells	cell	NNS
cord-007084-4niom5mw	210	28	or	or	CC
cord-007084-4niom5mw	210	29	in	in	IN
cord-007084-4niom5mw	210	30	vivo	vivo	NNP
cord-007084-4niom5mw	210	31	.	.	.
cord-007084-4niom5mw	211	1	Furthermore	furthermore	RB
cord-007084-4niom5mw	211	2	,	,	,
cord-007084-4niom5mw	211	3	the	the	DT
cord-007084-4niom5mw	211	4	possibility	possibility	NN
cord-007084-4niom5mw	211	5	that	that	IN
cord-007084-4niom5mw	211	6	the	the	DT
cord-007084-4niom5mw	211	7	aging	aging	NN
cord-007084-4niom5mw	211	8	process	process	NN
cord-007084-4niom5mw	211	9	directly	directly	RB
cord-007084-4niom5mw	211	10	affects	affect	VBZ
cord-007084-4niom5mw	211	11	the	the	DT
cord-007084-4niom5mw	211	12	performance	performance	NN
cord-007084-4niom5mw	211	13	(	(	-LRB-
cord-007084-4niom5mw	211	14	in	in	IN
cord-007084-4niom5mw	211	15	vivo	vivo	NNP
cord-007084-4niom5mw	211	16	)	)	-RRB-
cord-007084-4niom5mw	211	17	of	of	IN
cord-007084-4niom5mw	211	18	recently	recently	RB
cord-007084-4niom5mw	211	19	identified	identify	VBN
cord-007084-4niom5mw	211	20	regulator	regulator	NN
cord-007084-4niom5mw	211	21	(	(	-LRB-
cord-007084-4niom5mw	211	22	29	29	CD
cord-007084-4niom5mw	211	23	,	,	,
cord-007084-4niom5mw	211	24	(	(	-LRB-
cord-007084-4niom5mw	211	25	44	44	CD
cord-007084-4niom5mw	211	26	)	)	-RRB-
cord-007084-4niom5mw	211	27	(	(	-LRB-
cord-007084-4niom5mw	211	28	45	45	CD
cord-007084-4niom5mw	211	29	)	)	-RRB-
cord-007084-4niom5mw	211	30	(	(	-LRB-
cord-007084-4niom5mw	211	31	46	46	CD
cord-007084-4niom5mw	211	32	)	)	-RRB-
cord-007084-4niom5mw	211	33	(	(	-LRB-
cord-007084-4niom5mw	211	34	47	47	CD
cord-007084-4niom5mw	211	35	)	)	-RRB-
cord-007084-4niom5mw	211	36	(	(	-LRB-
cord-007084-4niom5mw	211	37	48	48	CD
cord-007084-4niom5mw	211	38	)	)	-RRB-
cord-007084-4niom5mw	211	39	(	(	-LRB-
cord-007084-4niom5mw	211	40	49	49	CD
cord-007084-4niom5mw	211	41	)	)	-RRB-
cord-007084-4niom5mw	211	42	(	(	-LRB-
cord-007084-4niom5mw	211	43	50	50	CD
cord-007084-4niom5mw	211	44	)	)	-RRB-
cord-007084-4niom5mw	211	45	(	(	-LRB-
cord-007084-4niom5mw	211	46	51	51	CD
cord-007084-4niom5mw	211	47	)	)	-RRB-
cord-007084-4niom5mw	211	48	(	(	-LRB-
cord-007084-4niom5mw	211	49	52	52	CD
cord-007084-4niom5mw	211	50	)	)	-RRB-
cord-007084-4niom5mw	211	51	(	(	-LRB-
cord-007084-4niom5mw	211	52	53	53	CD
cord-007084-4niom5mw	211	53	)	)	-RRB-
cord-007084-4niom5mw	211	54	(	(	-LRB-
cord-007084-4niom5mw	211	55	54	54	CD
cord-007084-4niom5mw	211	56	)	)	-RRB-
cord-007084-4niom5mw	211	57	(	(	-LRB-
cord-007084-4niom5mw	211	58	55	55	CD
cord-007084-4niom5mw	211	59	)	)	-RRB-
cord-007084-4niom5mw	211	60	of	of	IN
cord-007084-4niom5mw	211	61	the	the	DT
cord-007084-4niom5mw	211	62	side	side	NN
cord-007084-4niom5mw	211	63	-	-	HYPH
cord-007084-4niom5mw	211	64	chain	chain	NN
cord-007084-4niom5mw	211	65	cleavage	cleavage	NN
cord-007084-4niom5mw	211	66	enzyme	enzyme	NN
cord-007084-4niom5mw	211	67	activity	activity	NN
cord-007084-4niom5mw	211	68	should	should	MD
cord-007084-4niom5mw	211	69	also	also	RB
cord-007084-4niom5mw	211	70	be	be	VB
cord-007084-4niom5mw	211	71	considered	consider	VBN
cord-007084-4niom5mw	211	72	.	.	.
cord-007084-4niom5mw	212	1	Previous	previous	JJ
cord-007084-4niom5mw	212	2	reports	report	NNS
cord-007084-4niom5mw	212	3	indicate	indicate	VBP
cord-007084-4niom5mw	212	4	that	that	IN
cord-007084-4niom5mw	212	5	the	the	DT
cord-007084-4niom5mw	212	6	aging	age	VBG
cord-007084-4niom5mw	212	7	process	process	NN
cord-007084-4niom5mw	212	8	in	in	IN
cord-007084-4niom5mw	212	9	mouse	mouse	NN
cord-007084-4niom5mw	212	10	and	and	CC
cord-007084-4niom5mw	212	11	rat	rat	NN
cord-007084-4niom5mw	212	12	adrenals	adrenal	NNS
cord-007084-4niom5mw	212	13	is	be	VBZ
cord-007084-4niom5mw	212	14	associated	associate	VBN
cord-007084-4niom5mw	212	15	with	with	IN
cord-007084-4niom5mw	212	16	changes	change	NNS
cord-007084-4niom5mw	212	17	in	in	IN
cord-007084-4niom5mw	212	18	3/3-HSD	3/3-HSD	NNP
cord-007084-4niom5mw	212	19	(	(	-LRB-
cord-007084-4niom5mw	212	20	55	55	CD
cord-007084-4niom5mw	212	21	,	,	,
cord-007084-4niom5mw	212	22	56	56	CD
cord-007084-4niom5mw	212	23	)	)	-RRB-
cord-007084-4niom5mw	212	24	.	.	.
cord-007084-4niom5mw	213	1	We	-PRON-	PRP
cord-007084-4niom5mw	213	2	realize	realize	VBP
cord-007084-4niom5mw	213	3	that	that	IN
cord-007084-4niom5mw	213	4	our	-PRON-	PRP$
cord-007084-4niom5mw	213	5	inability	inability	NN
cord-007084-4niom5mw	213	6	to	to	TO
cord-007084-4niom5mw	213	7	demonstrate	demonstrate	VB
cord-007084-4niom5mw	213	8	an	an	DT
cord-007084-4niom5mw	213	9	age	age	NN
cord-007084-4niom5mw	213	10	effect	effect	NN
cord-007084-4niom5mw	213	11	on	on	IN
cord-007084-4niom5mw	213	12	this	this	DT
cord-007084-4niom5mw	213	13	enzyme	enzyme	NN
cord-007084-4niom5mw	213	14	are	be	VBP
cord-007084-4niom5mw	213	15	in	in	IN
cord-007084-4niom5mw	213	16	conflict	conflict	NN
cord-007084-4niom5mw	213	17	with	with	IN
cord-007084-4niom5mw	213	18	earlier	early	JJR
cord-007084-4niom5mw	213	19	studies	study	NNS
cord-007084-4niom5mw	213	20	(	(	-LRB-
cord-007084-4niom5mw	213	21	55	55	CD
cord-007084-4niom5mw	213	22	,	,	,
cord-007084-4niom5mw	213	23	56	56	CD
cord-007084-4niom5mw	213	24	)	)	-RRB-
cord-007084-4niom5mw	213	25	.	.	.
cord-007084-4niom5mw	214	1	Several	several	JJ
cord-007084-4niom5mw	214	2	technical	technical	JJ
cord-007084-4niom5mw	214	3	/	/	SYM
cord-007084-4niom5mw	214	4	physiological	physiological	JJ
cord-007084-4niom5mw	214	5	differences	difference	NNS
cord-007084-4niom5mw	214	6	in	in	IN
cord-007084-4niom5mw	214	7	the	the	DT
cord-007084-4niom5mw	214	8	experimental	experimental	JJ
cord-007084-4niom5mw	214	9	approach	approach	NN
cord-007084-4niom5mw	214	10	to	to	IN
cord-007084-4niom5mw	214	11	the	the	DT
cord-007084-4niom5mw	214	12	problem	problem	NN
cord-007084-4niom5mw	214	13	may	may	MD
cord-007084-4niom5mw	214	14	account	account	VB
cord-007084-4niom5mw	214	15	for	for	IN
cord-007084-4niom5mw	214	16	the	the	DT
cord-007084-4niom5mw	214	17	observed	observed	JJ
cord-007084-4niom5mw	214	18	incongruent	incongruent	JJ
cord-007084-4niom5mw	214	19	findings	finding	NNS
cord-007084-4niom5mw	214	20	.	.	.
cord-007084-4niom5mw	215	1	For	for	IN
cord-007084-4niom5mw	215	2	instance	instance	NN
cord-007084-4niom5mw	215	3	,	,	,
cord-007084-4niom5mw	215	4	the	the	DT
cord-007084-4niom5mw	215	5	earlier	early	JJR
cord-007084-4niom5mw	215	6	studies	study	NNS
cord-007084-4niom5mw	215	7	were	be	VBD
cord-007084-4niom5mw	215	8	carried	carry	VBN
cord-007084-4niom5mw	215	9	out	out	RP
cord-007084-4niom5mw	215	10	with	with	IN
cord-007084-4niom5mw	215	11	female	female	JJ
cord-007084-4niom5mw	215	12	rats	rat	NNS
cord-007084-4niom5mw	215	13	or	or	CC
cord-007084-4niom5mw	215	14	mice	mouse	NNS
cord-007084-4niom5mw	215	15	,	,	,
cord-007084-4niom5mw	215	16	as	as	IN
cord-007084-4niom5mw	215	17	opposed	oppose	VBN
cord-007084-4niom5mw	215	18	to	to	IN
cord-007084-4niom5mw	215	19	male	male	JJ
cord-007084-4niom5mw	215	20	rats	rat	NNS
cord-007084-4niom5mw	215	21	employed	employ	VBN
cord-007084-4niom5mw	215	22	in	in	IN
cord-007084-4niom5mw	215	23	the	the	DT
cord-007084-4niom5mw	215	24	present	present	JJ
cord-007084-4niom5mw	215	25	studies	study	NNS
cord-007084-4niom5mw	215	26	.	.	.
cord-007084-4niom5mw	216	1	Additionally	additionally	RB
cord-007084-4niom5mw	216	2	,	,	,
cord-007084-4niom5mw	216	3	variations	variation	NNS
cord-007084-4niom5mw	216	4	in	in	IN
cord-007084-4niom5mw	216	5	the	the	DT
cord-007084-4niom5mw	216	6	assay	assay	NN
cord-007084-4niom5mw	216	7	mixture	mixture	NN
cord-007084-4niom5mw	216	8	and	and	CC
cord-007084-4niom5mw	216	9	other	other	JJ
cord-007084-4niom5mw	216	10	experimental	experimental	JJ
cord-007084-4niom5mw	216	11	conditions	condition	NNS
cord-007084-4niom5mw	216	12	may	may	MD
cord-007084-4niom5mw	216	13	account	account	VB
cord-007084-4niom5mw	216	14	for	for	IN
cord-007084-4niom5mw	216	15	the	the	DT
cord-007084-4niom5mw	216	16	observed	observed	JJ
cord-007084-4niom5mw	216	17	discrepancy	discrepancy	NN
cord-007084-4niom5mw	216	18	.	.	.
cord-007084-4niom5mw	217	1	Likewise	likewise	RB
cord-007084-4niom5mw	217	2	,	,	,
cord-007084-4niom5mw	217	3	alterations	alteration	NNS
cord-007084-4niom5mw	217	4	in	in	IN
cord-007084-4niom5mw	217	5	nutritional	nutritional	JJ
cord-007084-4niom5mw	217	6	status	status	NN
cord-007084-4niom5mw	217	7	,	,	,
cord-007084-4niom5mw	217	8	animal	animal	NN
cord-007084-4niom5mw	217	9	strain	strain	NN
cord-007084-4niom5mw	217	10	,	,	,
cord-007084-4niom5mw	217	11	or	or	CC
cord-007084-4niom5mw	217	12	other	other	JJ
cord-007084-4niom5mw	217	13	physiological	physiological	JJ
cord-007084-4niom5mw	217	14	factors	factor	NNS
cord-007084-4niom5mw	217	15	could	could	MD
cord-007084-4niom5mw	217	16	also	also	RB
cord-007084-4niom5mw	217	17	contribute	contribute	VB
cord-007084-4niom5mw	217	18	significantly	significantly	RB
cord-007084-4niom5mw	217	19	.	.	.
cord-007084-4niom5mw	218	1	Finally	finally	RB
cord-007084-4niom5mw	218	2	,	,	,
cord-007084-4niom5mw	218	3	since	since	IN
cord-007084-4niom5mw	218	4	this	this	DT
cord-007084-4niom5mw	218	5	enzyme	enzyme	NN
cord-007084-4niom5mw	218	6	is	be	VBZ
cord-007084-4niom5mw	218	7	not	not	RB
cord-007084-4niom5mw	218	8	rate	rate	NN
cord-007084-4niom5mw	218	9	limiting	limit	VBG
cord-007084-4niom5mw	218	10	,	,	,
cord-007084-4niom5mw	218	11	even	even	RB
cord-007084-4niom5mw	218	12	a	a	DT
cord-007084-4niom5mw	218	13	modest	modest	JJ
cord-007084-4niom5mw	218	14	decline	decline	NN
cord-007084-4niom5mw	218	15	in	in	IN
cord-007084-4niom5mw	218	16	its	-PRON-	PRP$
cord-007084-4niom5mw	218	17	activity	activity	NN
cord-007084-4niom5mw	218	18	should	should	MD
cord-007084-4niom5mw	218	19	have	have	VB
cord-007084-4niom5mw	218	20	very	very	RB
cord-007084-4niom5mw	218	21	little	little	JJ
cord-007084-4niom5mw	218	22	adverse	adverse	JJ
cord-007084-4niom5mw	218	23	effect	effect	NN
cord-007084-4niom5mw	218	24	on	on	IN
cord-007084-4niom5mw	218	25	the	the	DT
cord-007084-4niom5mw	218	26	overall	overall	JJ
cord-007084-4niom5mw	218	27	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	218	28	capacity	capacity	NN
cord-007084-4niom5mw	218	29	of	of	IN
cord-007084-4niom5mw	218	30	the	the	DT
cord-007084-4niom5mw	218	31	adrenal	adrenal	JJ
cord-007084-4niom5mw	218	32	gland	gland	NN
cord-007084-4niom5mw	218	33	.	.	.
cord-007084-4niom5mw	219	1	Significant	significant	JJ
cord-007084-4niom5mw	219	2	changes	change	NNS
cord-007084-4niom5mw	219	3	in	in	IN
cord-007084-4niom5mw	219	4	some	some	DT
cord-007084-4niom5mw	219	5	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	219	6	enzymes	enzyme	NNS
cord-007084-4niom5mw	219	7	in	in	IN
cord-007084-4niom5mw	219	8	other	other	JJ
cord-007084-4niom5mw	219	9	steroid	steroid	NN
cord-007084-4niom5mw	219	10	-	-	HYPH
cord-007084-4niom5mw	219	11	producing	produce	VBG
cord-007084-4niom5mw	219	12	tissues	tissue	NNS
cord-007084-4niom5mw	219	13	have	have	VBP
cord-007084-4niom5mw	219	14	been	be	VBN
cord-007084-4niom5mw	219	15	demonstrated	demonstrate	VBN
cord-007084-4niom5mw	219	16	in	in	IN
cord-007084-4niom5mw	219	17	senescent	senescent	JJ
cord-007084-4niom5mw	219	18	rats	rat	NNS
cord-007084-4niom5mw	219	19	.	.	.
cord-007084-4niom5mw	220	1	For	for	IN
cord-007084-4niom5mw	220	2	example	example	NN
cord-007084-4niom5mw	220	3	,	,	,
cord-007084-4niom5mw	220	4	testicular	testicular	JJ
cord-007084-4niom5mw	220	5	30-HSD	30-hsd	CD
cord-007084-4niom5mw	220	6	activities	activity	NNS
cord-007084-4niom5mw	220	7	have	have	VBP
cord-007084-4niom5mw	220	8	been	be	VBN
cord-007084-4niom5mw	220	9	shown	show	VBN
cord-007084-4niom5mw	220	10	to	to	TO
cord-007084-4niom5mw	220	11	decline	decline	VB
cord-007084-4niom5mw	220	12	with	with	IN
cord-007084-4niom5mw	220	13	advancing	advance	VBG
cord-007084-4niom5mw	220	14	age	age	NN
cord-007084-4niom5mw	220	15	(	(	-LRB-
cord-007084-4niom5mw	220	16	57	57	CD
cord-007084-4niom5mw	220	17	)	)	-RRB-
cord-007084-4niom5mw	220	18	(	(	-LRB-
cord-007084-4niom5mw	220	19	58	58	CD
cord-007084-4niom5mw	220	20	)	)	-RRB-
cord-007084-4niom5mw	220	21	(	(	-LRB-
cord-007084-4niom5mw	220	22	59	59	CD
cord-007084-4niom5mw	220	23	)	)	-RRB-
cord-007084-4niom5mw	220	24	.	.	.
cord-007084-4niom5mw	221	1	Similarly	similarly	RB
cord-007084-4niom5mw	221	2	,	,	,
cord-007084-4niom5mw	221	3	other	other	JJ
cord-007084-4niom5mw	221	4	researchers	researcher	NNS
cord-007084-4niom5mw	221	5	have	have	VBP
cord-007084-4niom5mw	221	6	reported	report	VBN
cord-007084-4niom5mw	221	7	significant	significant	JJ
cord-007084-4niom5mw	221	8	age	age	NN
cord-007084-4niom5mw	221	9	-	-	HYPH
cord-007084-4niom5mw	221	10	related	relate	VBN
cord-007084-4niom5mw	221	11	loss	loss	NN
cord-007084-4niom5mw	221	12	of	of	IN
cord-007084-4niom5mw	221	13	this	this	DT
cord-007084-4niom5mw	221	14	enzyme	enzyme	NN
cord-007084-4niom5mw	221	15	activity	activity	NN
cord-007084-4niom5mw	221	16	in	in	IN
cord-007084-4niom5mw	221	17	rat	rat	NN
cord-007084-4niom5mw	221	18	ovary	ovary	NN
cord-007084-4niom5mw	221	19	(	(	-LRB-
cord-007084-4niom5mw	221	20	60	60	CD
cord-007084-4niom5mw	221	21	)	)	-RRB-
cord-007084-4niom5mw	221	22	(	(	-LRB-
cord-007084-4niom5mw	221	23	61	61	CD
cord-007084-4niom5mw	221	24	)	)	-RRB-
cord-007084-4niom5mw	221	25	(	(	-LRB-
cord-007084-4niom5mw	221	26	62	62	CD
cord-007084-4niom5mw	221	27	)	)	-RRB-
cord-007084-4niom5mw	221	28	.	.	.
cord-007084-4niom5mw	222	1	Likewise	likewise	RB
cord-007084-4niom5mw	222	2	,	,	,
cord-007084-4niom5mw	222	3	other	other	JJ
cord-007084-4niom5mw	222	4	researchers	researcher	NNS
cord-007084-4niom5mw	222	5	have	have	VBP
cord-007084-4niom5mw	222	6	presented	present	VBN
cord-007084-4niom5mw	222	7	evidence	evidence	NN
cord-007084-4niom5mw	222	8	that	that	IN
cord-007084-4niom5mw	222	9	activities	activity	NNS
cord-007084-4niom5mw	222	10	of	of	IN
cord-007084-4niom5mw	222	11	17a	17a	NNS
cord-007084-4niom5mw	222	12	-	-	HYPH
cord-007084-4niom5mw	222	13	hydroxylase	hydroxylase	NN
cord-007084-4niom5mw	222	14	(	(	-LRB-
cord-007084-4niom5mw	222	15	57	57	CD
cord-007084-4niom5mw	222	16	,	,	,
cord-007084-4niom5mw	222	17	59	59	CD
cord-007084-4niom5mw	222	18	,	,	,
cord-007084-4niom5mw	222	19	63	63	CD
cord-007084-4niom5mw	222	20	)	)	-RRB-
cord-007084-4niom5mw	222	21	,	,	,
cord-007084-4niom5mw	222	22	C17	C17	NNP
cord-007084-4niom5mw	222	23	-	-	HYPH
cord-007084-4niom5mw	222	24	20	20	CD
cord-007084-4niom5mw	222	25	lyase	lyase	NN
cord-007084-4niom5mw	222	26	(	(	-LRB-
cord-007084-4niom5mw	222	27	63	63	CD
cord-007084-4niom5mw	222	28	)	)	-RRB-
cord-007084-4niom5mw	222	29	,	,	,
cord-007084-4niom5mw	222	30	as	as	RB
cord-007084-4niom5mw	222	31	well	well	RB
cord-007084-4niom5mw	222	32	as	as	IN
cord-007084-4niom5mw	222	33	microsomal	microsomal	NNP
cord-007084-4niom5mw	222	34	cytochrome	cytochrome	NNP
cord-007084-4niom5mw	222	35	P-450	P-450	VBD
cord-007084-4niom5mw	222	36	(	(	-LRB-
cord-007084-4niom5mw	222	37	63	63	CD
cord-007084-4niom5mw	222	38	)	)	-RRB-
cord-007084-4niom5mw	222	39	are	be	VBP
cord-007084-4niom5mw	222	40	depressed	depress	VBN
cord-007084-4niom5mw	222	41	in	in	IN
cord-007084-4niom5mw	222	42	testes	testis	NNS
cord-007084-4niom5mw	222	43	from	from	IN
cord-007084-4niom5mw	222	44	aged	aged	JJ
cord-007084-4niom5mw	222	45	rats	rat	NNS
cord-007084-4niom5mw	222	46	.	.	.
cord-007084-4niom5mw	223	1	However	however	RB
cord-007084-4niom5mw	223	2	,	,	,
cord-007084-4niom5mw	223	3	comparison	comparison	NN
cord-007084-4niom5mw	223	4	of	of	IN
cord-007084-4niom5mw	223	5	data	datum	NNS
cord-007084-4niom5mw	223	6	from	from	IN
cord-007084-4niom5mw	223	7	different	different	JJ
cord-007084-4niom5mw	223	8	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	223	9	tissues	tissue	NNS
cord-007084-4niom5mw	223	10	suggests	suggest	VBZ
cord-007084-4niom5mw	223	11	that	that	IN
cord-007084-4niom5mw	223	12	changes	change	NNS
cord-007084-4niom5mw	223	13	in	in	IN
cord-007084-4niom5mw	223	14	enzyme	enzyme	NN
cord-007084-4niom5mw	223	15	activities	activity	NNS
cord-007084-4niom5mw	223	16	that	that	WDT
cord-007084-4niom5mw	223	17	occur	occur	VBP
cord-007084-4niom5mw	223	18	with	with	IN
cord-007084-4niom5mw	223	19	aging	age	VBG
cord-007084-4niom5mw	223	20	in	in	IN
cord-007084-4niom5mw	223	21	one	one	CD
cord-007084-4niom5mw	223	22	steroid	steroid	NN
cord-007084-4niom5mw	223	23	-	-	HYPH
cord-007084-4niom5mw	223	24	producing	produce	VBG
cord-007084-4niom5mw	223	25	tissue	tissue	NN
cord-007084-4niom5mw	223	26	may	may	MD
cord-007084-4niom5mw	223	27	not	not	RB
cord-007084-4niom5mw	223	28	necessarily	necessarily	RB
cord-007084-4niom5mw	223	29	be	be	VB
cord-007084-4niom5mw	223	30	applicable	applicable	JJ
cord-007084-4niom5mw	223	31	to	to	IN
cord-007084-4niom5mw	223	32	other	other	JJ
cord-007084-4niom5mw	223	33	steroid	steroid	NN
cord-007084-4niom5mw	223	34	-	-	HYPH
cord-007084-4niom5mw	223	35	producing	produce	VBG
cord-007084-4niom5mw	223	36	tissues	tissue	NNS
cord-007084-4niom5mw	223	37	.	.	.
cord-007084-4niom5mw	224	1	In	in	IN
cord-007084-4niom5mw	224	2	conclusion	conclusion	NN
cord-007084-4niom5mw	224	3	,	,	,
cord-007084-4niom5mw	224	4	the	the	DT
cord-007084-4niom5mw	224	5	results	result	NNS
cord-007084-4niom5mw	224	6	of	of	IN
cord-007084-4niom5mw	224	7	the	the	DT
cord-007084-4niom5mw	224	8	present	present	JJ
cord-007084-4niom5mw	224	9	study	study	NN
cord-007084-4niom5mw	224	10	suggest	suggest	VBP
cord-007084-4niom5mw	224	11	that	that	IN
cord-007084-4niom5mw	224	12	the	the	DT
cord-007084-4niom5mw	224	13	impairment	impairment	NN
cord-007084-4niom5mw	224	14	of	of	IN
cord-007084-4niom5mw	224	15	corticosterone	corticosterone	NN
cord-007084-4niom5mw	224	16	secretion	secretion	NN
cord-007084-4niom5mw	224	17	in	in	IN
cord-007084-4niom5mw	224	18	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	224	19	cells	cell	NNS
cord-007084-4niom5mw	224	20	isolated	isolate	VBN
cord-007084-4niom5mw	224	21	from	from	IN
cord-007084-4niom5mw	224	22	senescent	senescent	JJ
cord-007084-4niom5mw	224	23	rats	rat	NNS
cord-007084-4niom5mw	224	24	is	be	VBZ
cord-007084-4niom5mw	224	25	probably	probably	RB
cord-007084-4niom5mw	224	26	not	not	RB
cord-007084-4niom5mw	224	27	related	relate	VBN
cord-007084-4niom5mw	224	28	to	to	IN
cord-007084-4niom5mw	224	29	a	a	DT
cord-007084-4niom5mw	224	30	reduction	reduction	NN
cord-007084-4niom5mw	224	31	in	in	IN
cord-007084-4niom5mw	224	32	the	the	DT
cord-007084-4niom5mw	224	33	activity	activity	NN
cord-007084-4niom5mw	224	34	of	of	IN
cord-007084-4niom5mw	224	35	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	224	36	enzymes	enzyme	NNS
cord-007084-4niom5mw	224	37	,	,	,
cord-007084-4niom5mw	224	38	as	as	IN
cord-007084-4niom5mw	224	39	measured	measure	VBN
cord-007084-4niom5mw	224	40	in	in	IN
cord-007084-4niom5mw	224	41	vitro	vitro	FW
cord-007084-4niom5mw	224	42	.	.	.
cord-007084-4niom5mw	225	1	However	however	RB
cord-007084-4niom5mw	225	2	,	,	,
cord-007084-4niom5mw	225	3	since	since	IN
cord-007084-4niom5mw	225	4	the	the	DT
cord-007084-4niom5mw	225	5	transport	transport	NN
cord-007084-4niom5mw	225	6	of	of	IN
cord-007084-4niom5mw	225	7	cholesterol	cholesterol	NN
cord-007084-4niom5mw	225	8	to	to	IN
cord-007084-4niom5mw	225	9	cytochrome	cytochrome	NN
cord-007084-4niom5mw	225	10	P450	P450	NNP
cord-007084-4niom5mw	225	11	scc	scc	NNP
cord-007084-4niom5mw	225	12	rather	rather	RB
cord-007084-4niom5mw	225	13	than	than	IN
cord-007084-4niom5mw	225	14	the	the	DT
cord-007084-4niom5mw	225	15	activity	activity	NN
cord-007084-4niom5mw	225	16	of	of	IN
cord-007084-4niom5mw	225	17	cytochrome	cytochrome	NN
cord-007084-4niom5mw	225	18	P450	P450	NNP
cord-007084-4niom5mw	225	19	scc	scc	NN
cord-007084-4niom5mw	225	20	per	per	FW
cord-007084-4niom5mw	225	21	se	se	FW
cord-007084-4niom5mw	225	22	limits	limit	VBZ
cord-007084-4niom5mw	225	23	the	the	DT
cord-007084-4niom5mw	225	24	rate	rate	NN
cord-007084-4niom5mw	225	25	of	of	IN
cord-007084-4niom5mw	225	26	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	225	27	,	,	,
cord-007084-4niom5mw	225	28	it	-PRON-	PRP
cord-007084-4niom5mw	225	29	is	be	VBZ
cord-007084-4niom5mw	225	30	possible	possible	JJ
cord-007084-4niom5mw	225	31	at	at	IN
cord-007084-4niom5mw	225	32	this	this	DT
cord-007084-4niom5mw	225	33	time	time	NN
cord-007084-4niom5mw	225	34	to	to	IN
cord-007084-4niom5mw	225	35	at	at	IN
cord-007084-4niom5mw	225	36	least	least	JJS
cord-007084-4niom5mw	225	37	speculate	speculate	VB
cord-007084-4niom5mw	225	38	that	that	IN
cord-007084-4niom5mw	225	39	the	the	DT
cord-007084-4niom5mw	225	40	age	age	NN
cord-007084-4niom5mw	225	41	-	-	HYPH
cord-007084-4niom5mw	225	42	related	relate	VBN
cord-007084-4niom5mw	225	43	decline	decline	NN
cord-007084-4niom5mw	225	44	in	in	IN
cord-007084-4niom5mw	225	45	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	225	46	is	be	VBZ
cord-007084-4niom5mw	225	47	related	relate	VBN
cord-007084-4niom5mw	225	48	to	to	IN
cord-007084-4niom5mw	225	49	a	a	DT
cord-007084-4niom5mw	225	50	decrease	decrease	NN
cord-007084-4niom5mw	225	51	in	in	IN
cord-007084-4niom5mw	225	52	the	the	DT
cord-007084-4niom5mw	225	53	transport	transport	NN
cord-007084-4niom5mw	225	54	of	of	IN
cord-007084-4niom5mw	225	55	cholesterol	cholesterol	NN
cord-007084-4niom5mw	225	56	to	to	IN
cord-007084-4niom5mw	225	57	the	the	DT
cord-007084-4niom5mw	225	58	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	225	59	.	.	.
cord-007084-4niom5mw	226	1	The	the	DT
cord-007084-4niom5mw	226	2	roles	role	NNS
cord-007084-4niom5mw	226	3	of	of	IN
cord-007084-4niom5mw	226	4	microtubules	microtubule	NNS
cord-007084-4niom5mw	226	5	(	(	-LRB-
cord-007084-4niom5mw	226	6	44	44	CD
cord-007084-4niom5mw	226	7	)	)	-RRB-
cord-007084-4niom5mw	226	8	,	,	,
cord-007084-4niom5mw	226	9	microfilaments	microfilaments	NNP
cord-007084-4niom5mw	226	10	(	(	-LRB-
cord-007084-4niom5mw	226	11	44	44	CD
cord-007084-4niom5mw	226	12	)	)	-RRB-
cord-007084-4niom5mw	226	13	,	,	,
cord-007084-4niom5mw	226	14	phospholipids	phospholipid	NNS
cord-007084-4niom5mw	226	15	(	(	-LRB-
cord-007084-4niom5mw	226	16	40	40	CD
cord-007084-4niom5mw	226	17	,	,	,
cord-007084-4niom5mw	226	18	(	(	-LRB-
cord-007084-4niom5mw	226	19	45	45	CD
cord-007084-4niom5mw	226	20	)	)	-RRB-
cord-007084-4niom5mw	226	21	(	(	-LRB-
cord-007084-4niom5mw	226	22	46	46	CD
cord-007084-4niom5mw	226	23	)	)	-RRB-
cord-007084-4niom5mw	226	24	(	(	-LRB-
cord-007084-4niom5mw	226	25	47	47	CD
cord-007084-4niom5mw	226	26	)	)	-RRB-
cord-007084-4niom5mw	226	27	52	52	CD
cord-007084-4niom5mw	226	28	)	)	-RRB-
cord-007084-4niom5mw	226	29	,	,	,
cord-007084-4niom5mw	226	30	sterol	sterol	NN
cord-007084-4niom5mw	226	31	carrier	carrier	NN
cord-007084-4niom5mw	226	32	proteins	protein	NNS
cord-007084-4niom5mw	226	33	(	(	-LRB-
cord-007084-4niom5mw	226	34	48	48	CD
cord-007084-4niom5mw	226	35	)	)	-RRB-
cord-007084-4niom5mw	226	36	(	(	-LRB-
cord-007084-4niom5mw	226	37	49	49	CD
cord-007084-4niom5mw	226	38	)	)	-RRB-
cord-007084-4niom5mw	226	39	(	(	-LRB-
cord-007084-4niom5mw	226	40	50	50	CD
cord-007084-4niom5mw	226	41	)	)	-RRB-
cord-007084-4niom5mw	226	42	(	(	-LRB-
cord-007084-4niom5mw	226	43	51	51	CD
cord-007084-4niom5mw	226	44	)	)	-RRB-
cord-007084-4niom5mw	226	45	,	,	,
cord-007084-4niom5mw	226	46	and	and	CC
cord-007084-4niom5mw	226	47	other	other	JJ
cord-007084-4niom5mw	226	48	factors	factor	NNS
cord-007084-4niom5mw	226	49	(	(	-LRB-
cord-007084-4niom5mw	226	50	28	28	CD
cord-007084-4niom5mw	226	51	,	,	,
cord-007084-4niom5mw	226	52	53	53	CD
cord-007084-4niom5mw	226	53	,	,	,
cord-007084-4niom5mw	226	54	54	54	CD
cord-007084-4niom5mw	226	55	)	)	-RRB-
cord-007084-4niom5mw	226	56	have	have	VBP
cord-007084-4niom5mw	226	57	all	all	DT
cord-007084-4niom5mw	226	58	been	be	VBN
cord-007084-4niom5mw	226	59	described	describe	VBN
cord-007084-4niom5mw	226	60	as	as	IN
cord-007084-4niom5mw	226	61	playing	play	VBG
cord-007084-4niom5mw	226	62	a	a	DT
cord-007084-4niom5mw	226	63	part	part	NN
cord-007084-4niom5mw	226	64	in	in	IN
cord-007084-4niom5mw	226	65	cholesterol	cholesterol	NN
cord-007084-4niom5mw	226	66	transport	transport	NN
cord-007084-4niom5mw	226	67	.	.	.
cord-007084-4niom5mw	227	1	Failure	failure	NN
cord-007084-4niom5mw	227	2	of	of	IN
cord-007084-4niom5mw	227	3	or	or	CC
cord-007084-4niom5mw	227	4	changes	change	NNS
cord-007084-4niom5mw	227	5	in	in	IN
cord-007084-4niom5mw	227	6	any	any	DT
cord-007084-4niom5mw	227	7	of	of	IN
cord-007084-4niom5mw	227	8	these	these	DT
cord-007084-4niom5mw	227	9	mechanisms	mechanism	NNS
cord-007084-4niom5mw	227	10	with	with	IN
cord-007084-4niom5mw	227	11	age	age	NN
cord-007084-4niom5mw	227	12	would	would	MD
cord-007084-4niom5mw	227	13	reduce	reduce	VB
cord-007084-4niom5mw	227	14	the	the	DT
cord-007084-4niom5mw	227	15	amount	amount	NN
cord-007084-4niom5mw	227	16	of	of	IN
cord-007084-4niom5mw	227	17	cholesterol	cholesterol	NN
cord-007084-4niom5mw	227	18	substrate	substrate	NN
cord-007084-4niom5mw	227	19	available	available	JJ
cord-007084-4niom5mw	227	20	for	for	IN
cord-007084-4niom5mw	227	21	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	227	22	within	within	IN
cord-007084-4niom5mw	227	23	the	the	DT
cord-007084-4niom5mw	227	24	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	227	25	,	,	,
cord-007084-4niom5mw	227	26	and	and	CC
cord-007084-4niom5mw	227	27	we	-PRON-	PRP
cord-007084-4niom5mw	227	28	are	be	VBP
cord-007084-4niom5mw	227	29	presently	presently	RB
cord-007084-4niom5mw	227	30	studying	study	VBG
cord-007084-4niom5mw	227	31	the	the	DT
cord-007084-4niom5mw	227	32	possibility	possibility	NN
cord-007084-4niom5mw	227	33	that	that	IN
cord-007084-4niom5mw	227	34	cholesterol	cholesterol	NN
cord-007084-4niom5mw	227	35	transport	transport	NN
cord-007084-4niom5mw	227	36	is	be	VBZ
cord-007084-4niom5mw	227	37	also	also	RB
cord-007084-4niom5mw	227	38	altered	alter	VBN
cord-007084-4niom5mw	227	39	with	with	IN
cord-007084-4niom5mw	227	40	age	age	NN
cord-007084-4niom5mw	227	41	.	.	.
cord-007084-4niom5mw	228	1	Differential	differential	JJ
cord-007084-4niom5mw	228	2	effects	effect	NNS
cord-007084-4niom5mw	228	3	of	of	IN
cord-007084-4niom5mw	228	4	aging	age	VBG
cord-007084-4niom5mw	228	5	on	on	IN
cord-007084-4niom5mw	228	6	ACTH	ACTH	NNP
cord-007084-4niom5mw	228	7	receptors	receptor	NNS
cord-007084-4niom5mw	228	8	,	,	,
cord-007084-4niom5mw	228	9	adenosine	adenosine	NN
cord-007084-4niom5mw	228	10	3',5	3',5	JJ
cord-007084-4niom5mw	228	11	'	'	``
cord-007084-4niom5mw	228	12	cyclic	cyclic	JJ
cord-007084-4niom5mw	228	13	monophosphate	monophosphate	NN
cord-007084-4niom5mw	228	14	response	response	NN
cord-007084-4niom5mw	228	15	and	and	CC
cord-007084-4niom5mw	228	16	corticosterone	corticosterone	NN
cord-007084-4niom5mw	228	17	secretion	secretion	NN
cord-007084-4niom5mw	228	18	in	in	IN
cord-007084-4niom5mw	228	19	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	228	20	cells	cell	NNS
cord-007084-4niom5mw	228	21	from	from	IN
cord-007084-4niom5mw	228	22	Sprague	Sprague	NNP
cord-007084-4niom5mw	228	23	-	-	HYPH
cord-007084-4niom5mw	228	24	Dawley	Dawley	NNP
cord-007084-4niom5mw	228	25	rats	rat	NNS
cord-007084-4niom5mw	228	26	On	on	IN
cord-007084-4niom5mw	228	27	the	the	DT
cord-007084-4niom5mw	228	28	mechanism	mechanism	NN
cord-007084-4niom5mw	228	29	of	of	IN
cord-007084-4niom5mw	228	30	action	action	NN
cord-007084-4niom5mw	228	31	of	of	IN
cord-007084-4niom5mw	228	32	ACTH	ACTH	NNP
cord-007084-4niom5mw	228	33	Adrenal	adrenal	JJ
cord-007084-4niom5mw	228	34	gland	gland	NN
cord-007084-4niom5mw	228	35	Cholesterol	cholesterol	NN
cord-007084-4niom5mw	228	36	side	side	NN
cord-007084-4niom5mw	228	37	-	-	HYPH
cord-007084-4niom5mw	228	38	chain	chain	NN
cord-007084-4niom5mw	228	39	cleavage	cleavage	NN
cord-007084-4niom5mw	228	40	,	,	,
cord-007084-4niom5mw	228	41	cytochrome	cytochrome	NN
cord-007084-4niom5mw	228	42	P450	p450	NN
cord-007084-4niom5mw	228	43	,	,	,
cord-007084-4niom5mw	228	44	and	and	CC
cord-007084-4niom5mw	228	45	the	the	DT
cord-007084-4niom5mw	228	46	control	control	NN
cord-007084-4niom5mw	228	47	of	of	IN
cord-007084-4niom5mw	228	48	steroidogenesis	steroidogenesis	NNP
cord-007084-4niom5mw	228	49	Cholesterol	cholesterol	NN
cord-007084-4niom5mw	228	50	metabolism	metabolism	NN
cord-007084-4niom5mw	228	51	in	in	IN
cord-007084-4niom5mw	228	52	the	the	DT
cord-007084-4niom5mw	228	53	adrenal	adrenal	JJ
cord-007084-4niom5mw	228	54	cortex	cortex	NN
cord-007084-4niom5mw	228	55	Regulation	Regulation	NNP
cord-007084-4niom5mw	228	56	of	of	IN
cord-007084-4niom5mw	228	57	the	the	DT
cord-007084-4niom5mw	228	58	adrenal	adrenal	JJ
cord-007084-4niom5mw	228	59	and	and	CC
cord-007084-4niom5mw	228	60	gonadal	gonadal	NNP
cord-007084-4niom5mw	228	61	microsomal	microsomal	NNP
cord-007084-4niom5mw	228	62	mixed	mixed	JJ
cord-007084-4niom5mw	228	63	function	function	NN
cord-007084-4niom5mw	228	64	oxygenases	oxygenase	NNS
cord-007084-4niom5mw	228	65	of	of	IN
cord-007084-4niom5mw	228	66	steroid	steroid	NN
cord-007084-4niom5mw	228	67	hormone	hormone	NN
cord-007084-4niom5mw	228	68	biosynthesis	biosynthesis	NN
cord-007084-4niom5mw	229	1	The	the	DT
cord-007084-4niom5mw	229	2	roles	role	NNS
cord-007084-4niom5mw	229	3	of	of	IN
cord-007084-4niom5mw	229	4	cytochrome	cytochrome	NN
cord-007084-4niom5mw	229	5	P450	p450	NN
cord-007084-4niom5mw	229	6	in	in	IN
cord-007084-4niom5mw	229	7	the	the	DT
cord-007084-4niom5mw	229	8	synthesis	synthesis	NN
cord-007084-4niom5mw	229	9	and	and	CC
cord-007084-4niom5mw	229	10	metabolism	metabolism	NN
cord-007084-4niom5mw	229	11	of	of	IN
cord-007084-4niom5mw	229	12	steroids	steroid	NNS
cord-007084-4niom5mw	230	1	A	a	DT
cord-007084-4niom5mw	230	2	heuristic	heuristic	JJ
cord-007084-4niom5mw	230	3	proposal	proposal	NN
cord-007084-4niom5mw	230	4	for	for	IN
cord-007084-4niom5mw	230	5	understanding	understand	VBG
cord-007084-4niom5mw	230	6	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	230	7	processes	process	NNS
cord-007084-4niom5mw	231	1	The	the	DT
cord-007084-4niom5mw	231	2	mechanism	mechanism	NN
cord-007084-4niom5mw	231	3	of	of	IN
cord-007084-4niom5mw	231	4	action	action	NN
cord-007084-4niom5mw	231	5	of	of	IN
cord-007084-4niom5mw	231	6	adrenocorticotropic	adrenocorticotropic	NNP
cord-007084-4niom5mw	231	7	hormone	hormone	NNP
cord-007084-4niom5mw	231	8	:	:	:
cord-007084-4niom5mw	231	9	the	the	DT
cord-007084-4niom5mw	231	10	role	role	NN
cord-007084-4niom5mw	231	11	of	of	IN
cord-007084-4niom5mw	231	12	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	231	13	cholesterol	cholesterol	NN
cord-007084-4niom5mw	231	14	accumulation	accumulation	NN
cord-007084-4niom5mw	231	15	in	in	IN
cord-007084-4niom5mw	231	16	the	the	DT
cord-007084-4niom5mw	231	17	regulation	regulation	NN
cord-007084-4niom5mw	231	18	of	of	IN
cord-007084-4niom5mw	231	19	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	231	20	Evidence	evidence	NN
cord-007084-4niom5mw	231	21	that	that	IN
cord-007084-4niom5mw	231	22	the	the	DT
cord-007084-4niom5mw	231	23	cyclohexamide	cyclohexamide	NN
cord-007084-4niom5mw	231	24	-	-	HYPH
cord-007084-4niom5mw	231	25	sensitive	sensitive	JJ
cord-007084-4niom5mw	231	26	site	site	NN
cord-007084-4niom5mw	231	27	of	of	IN
cord-007084-4niom5mw	231	28	adrenocorticotropic	adrenocorticotropic	NNP
cord-007084-4niom5mw	231	29	hormone	hormone	NN
cord-007084-4niom5mw	231	30	action	action	NN
cord-007084-4niom5mw	231	31	is	be	VBZ
cord-007084-4niom5mw	231	32	in	in	IN
cord-007084-4niom5mw	231	33	the	the	DT
cord-007084-4niom5mw	231	34	mitochondrion	mitochondrion	NN
cord-007084-4niom5mw	231	35	:	:	:
cord-007084-4niom5mw	231	36	changes	change	NNS
cord-007084-4niom5mw	231	37	in	in	IN
cord-007084-4niom5mw	231	38	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	231	39	formation	formation	NN
cord-007084-4niom5mw	231	40	,	,	,
cord-007084-4niom5mw	231	41	cholesterol	cholesterol	NN
cord-007084-4niom5mw	231	42	content	content	NN
cord-007084-4niom5mw	231	43	,	,	,
cord-007084-4niom5mw	231	44	and	and	CC
cord-007084-4niom5mw	231	45	the	the	DT
cord-007084-4niom5mw	231	46	electron	electron	NN
cord-007084-4niom5mw	231	47	paramagnetic	paramagnetic	JJ
cord-007084-4niom5mw	231	48	resonance	resonance	NN
cord-007084-4niom5mw	231	49	spectra	spectrum	NNS
cord-007084-4niom5mw	231	50	of	of	IN
cord-007084-4niom5mw	231	51	cytochrome	cytochrome	NN
cord-007084-4niom5mw	231	52	P-450	p-450	XX
cord-007084-4niom5mw	232	1	Regulation	regulation	NN
cord-007084-4niom5mw	232	2	of	of	IN
cord-007084-4niom5mw	232	3	cytochrome	cytochrome	NN
cord-007084-4niom5mw	232	4	P-450	p-450	NN
cord-007084-4niom5mw	232	5	supported	support	VBD
cord-007084-4niom5mw	232	6	11-/3-hydroxylation	11-/3-hydroxylation	CD
cord-007084-4niom5mw	232	7	of	of	IN
cord-007084-4niom5mw	232	8	deoxycortisol	deoxycortisol	NNP
cord-007084-4niom5mw	232	9	by	by	IN
cord-007084-4niom5mw	232	10	steroids	steroid	NNS
cord-007084-4niom5mw	232	11	,	,	,
cord-007084-4niom5mw	232	12	oxygen	oxygen	NN
cord-007084-4niom5mw	232	13	and	and	CC
cord-007084-4niom5mw	232	14	antioxidants	antioxidant	NNS
cord-007084-4niom5mw	232	15	in	in	IN
cord-007084-4niom5mw	232	16	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	232	17	cell	cell	NN
cord-007084-4niom5mw	232	18	cultures	culture	NNS
cord-007084-4niom5mw	232	19	Life	Life	NNP
cord-007084-4niom5mw	232	20	time	time	NN
cord-007084-4niom5mw	232	21	of	of	IN
cord-007084-4niom5mw	232	22	adrenal	adrenal	JJ
cord-007084-4niom5mw	232	23	cytochrome	cytochrome	NN
cord-007084-4niom5mw	232	24	P450	P450	NNP
cord-007084-4niom5mw	232	25	as	as	IN
cord-007084-4niom5mw	232	26	influenced	influence	VBN
cord-007084-4niom5mw	232	27	by	by	IN
cord-007084-4niom5mw	232	28	ACTH	ACTH	NNP
cord-007084-4niom5mw	232	29	Mechanism	Mechanism	NNP
cord-007084-4niom5mw	232	30	of	of	IN
cord-007084-4niom5mw	232	31	induction	induction	NN
cord-007084-4niom5mw	232	32	of	of	IN
cord-007084-4niom5mw	232	33	A	a	DT
cord-007084-4niom5mw	232	34	5	5	CD
cord-007084-4niom5mw	232	35	-3/	-3/	.
cord-007084-4niom5mw	233	1	Miydroxysteroid	miydroxysteroid	JJ
cord-007084-4niom5mw	233	2	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	233	3	-	-	HYPH
cord-007084-4niom5mw	233	4	isomerase	isomerase	NN
cord-007084-4niom5mw	233	5	activity	activity	NN
cord-007084-4niom5mw	233	6	in	in	IN
cord-007084-4niom5mw	233	7	rat	rat	NN
cord-007084-4niom5mw	233	8	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	233	9	cells	cell	NNS
cord-007084-4niom5mw	233	10	by	by	IN
cord-007084-4niom5mw	233	11	corticotropin	corticotropin	NNP
cord-007084-4niom5mw	233	12	Steroidogenic	Steroidogenic	NNP
cord-007084-4niom5mw	233	13	enzyme	enzyme	NN
cord-007084-4niom5mw	233	14	activities	activity	NNS
cord-007084-4niom5mw	233	15	in	in	IN
cord-007084-4niom5mw	233	16	cultured	cultured	JJ
cord-007084-4niom5mw	233	17	human	human	JJ
cord-007084-4niom5mw	233	18	definitive	definitive	JJ
cord-007084-4niom5mw	233	19	zone	zone	NN
cord-007084-4niom5mw	233	20	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	233	21	cells	cell	NNS
cord-007084-4niom5mw	233	22	:	:	:
cord-007084-4niom5mw	233	23	comparison	comparison	NN
cord-007084-4niom5mw	233	24	with	with	IN
cord-007084-4niom5mw	233	25	bovine	bovine	JJ
cord-007084-4niom5mw	233	26	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	233	27	cells	cell	NNS
cord-007084-4niom5mw	233	28	and	and	CC
cord-007084-4niom5mw	233	29	resultant	resultant	JJ
cord-007084-4niom5mw	233	30	differences	difference	NNS
cord-007084-4niom5mw	233	31	in	in	IN
cord-007084-4niom5mw	233	32	adrenal	adrenal	JJ
cord-007084-4niom5mw	233	33	androgen	androgen	NN
cord-007084-4niom5mw	233	34	synthesis	synthesis	NN
cord-007084-4niom5mw	234	1	In	in	IN
cord-007084-4niom5mw	234	2	vitro	vitro	FW
cord-007084-4niom5mw	234	3	spontaneous	spontaneous	JJ
cord-007084-4niom5mw	234	4	and	and	CC
cord-007084-4niom5mw	234	5	adrenocorticotropin	adrenocorticotropin	JJ
cord-007084-4niom5mw	234	6	dependent	dependent	JJ
cord-007084-4niom5mw	234	7	maturation	maturation	NN
cord-007084-4niom5mw	234	8	of	of	IN
cord-007084-4niom5mw	234	9	the	the	DT
cord-007084-4niom5mw	234	10	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	234	11	pathway	pathway	NN
cord-007084-4niom5mw	234	12	of	of	IN
cord-007084-4niom5mw	234	13	ovine	ovine	JJ
cord-007084-4niom5mw	234	14	fetal	fetal	JJ
cord-007084-4niom5mw	234	15	adrenal	adrenal	JJ
cord-007084-4niom5mw	234	16	cells	cell	NNS
cord-007084-4niom5mw	234	17	Relationship	relationship	NN
cord-007084-4niom5mw	234	18	of	of	IN
cord-007084-4niom5mw	234	19	cholesterol	cholesterol	NN
cord-007084-4niom5mw	234	20	supply	supply	NN
cord-007084-4niom5mw	234	21	to	to	IN
cord-007084-4niom5mw	234	22	luteal	luteal	JJ
cord-007084-4niom5mw	234	23	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	234	24	steroid	steroid	NN
cord-007084-4niom5mw	234	25	synthesis	synthesis	NN
cord-007084-4niom5mw	235	1	The	the	DT
cord-007084-4niom5mw	235	2	site	site	NN
cord-007084-4niom5mw	235	3	of	of	IN
cord-007084-4niom5mw	235	4	luteinizing	luteinize	VBG
cord-007084-4niom5mw	235	5	hormoe	hormoe	NN
cord-007084-4niom5mw	235	6	stimulation	stimulation	NN
cord-007084-4niom5mw	235	7	of	of	IN
cord-007084-4niom5mw	235	8	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	235	9	in	in	IN
cord-007084-4niom5mw	235	10	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	235	11	of	of	IN
cord-007084-4niom5mw	235	12	the	the	DT
cord-007084-4niom5mw	235	13	rat	rat	NN
cord-007084-4niom5mw	235	14	corpus	corpus	NNP
cord-007084-4niom5mw	235	15	luteum	luteum	NN
cord-007084-4niom5mw	235	16	Oxygen	oxygen	NN
cord-007084-4niom5mw	235	17	dependence	dependence	NN
cord-007084-4niom5mw	235	18	of	of	IN
cord-007084-4niom5mw	235	19	adrenal	adrenal	JJ
cord-007084-4niom5mw	235	20	cortex	cortex	NNP
cord-007084-4niom5mw	235	21	cholesterol	cholesterol	NN
cord-007084-4niom5mw	235	22	side	side	NN
cord-007084-4niom5mw	235	23	chain	chain	NN
cord-007084-4niom5mw	235	24	cleavage	cleavage	NN
cord-007084-4niom5mw	235	25	'	'	''
cord-007084-4niom5mw	235	26	:	:	:
cord-007084-4niom5mw	235	27	implications	implication	NNS
cord-007084-4niom5mw	235	28	in	in	IN
cord-007084-4niom5mw	235	29	the	the	DT
cord-007084-4niom5mw	235	30	rate	rate	NN
cord-007084-4niom5mw	235	31	-	-	HYPH
cord-007084-4niom5mw	235	32	limiting	limit	VBG
cord-007084-4niom5mw	235	33	steps	step	NNS
cord-007084-4niom5mw	235	34	in	in	IN
cord-007084-4niom5mw	235	35	steroidogenesis	steroidogenesis	NNP
cord-007084-4niom5mw	235	36	Radioimm'unoassay	Radioimm'unoassay	NNP
cord-007084-4niom5mw	235	37	of	of	IN
cord-007084-4niom5mw	235	38	serum	serum	NN
cord-007084-4niom5mw	235	39	and	and	CC
cord-007084-4niom5mw	235	40	ovarian	ovarian	JJ
cord-007084-4niom5mw	235	41	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	235	42	in	in	IN
cord-007084-4niom5mw	235	43	immature	immature	JJ
cord-007084-4niom5mw	235	44	rats	rat	NNS
cord-007084-4niom5mw	235	45	Synergistic	synergistic	JJ
cord-007084-4niom5mw	235	46	effect	effect	NN
cord-007084-4niom5mw	235	47	of	of	IN
cord-007084-4niom5mw	235	48	follicle	follicle	NN
cord-007084-4niom5mw	235	49	-	-	HYPH
cord-007084-4niom5mw	235	50	stimulating	stimulate	VBG
cord-007084-4niom5mw	235	51	hormone	hormone	NN
cord-007084-4niom5mw	235	52	and	and	CC
cord-007084-4niom5mw	235	53	luteinizing	luteinize	VBG
cord-007084-4niom5mw	235	54	hormone	hormone	NN
cord-007084-4niom5mw	235	55	on	on	IN
cord-007084-4niom5mw	235	56	testicular	testicular	NN
cord-007084-4niom5mw	236	1	A	a	DT
cord-007084-4niom5mw	237	1	5	5	LS
cord-007084-4niom5mw	237	2	-3/3-hydroxysteroid	-3/3-hydroxysteroid	JJ
cord-007084-4niom5mw	237	3	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	237	4	-	-	HYPH
cord-007084-4niom5mw	237	5	isomerase	isomerase	NN
cord-007084-4niom5mw	237	6	:	:	:
cord-007084-4niom5mw	237	7	application	application	NN
cord-007084-4niom5mw	237	8	of	of	IN
cord-007084-4niom5mw	237	9	a	a	DT
cord-007084-4niom5mw	237	10	new	new	JJ
cord-007084-4niom5mw	237	11	method	method	NN
cord-007084-4niom5mw	237	12	for	for	IN
cord-007084-4niom5mw	237	13	the	the	DT
cord-007084-4niom5mw	237	14	separation	separation	NN
cord-007084-4niom5mw	237	15	of	of	IN
cord-007084-4niom5mw	237	16	testicular	testicular	NN
cord-007084-4niom5mw	237	17	compartments	compartment	NNS
cord-007084-4niom5mw	237	18	Spironolactone	Spironolactone	NNP
cord-007084-4niom5mw	237	19	and	and	CC
cord-007084-4niom5mw	237	20	cytochrome	cytochrome	NN
cord-007084-4niom5mw	238	1	P-450	p-450	CC
cord-007084-4niom5mw	238	2	:	:	:
cord-007084-4niom5mw	238	3	impairment	impairment	NN
cord-007084-4niom5mw	238	4	of	of	IN
cord-007084-4niom5mw	238	5	steroid	steroid	NN
cord-007084-4niom5mw	238	6	21-hydroxylation	21-hydroxylation	CD
cord-007084-4niom5mw	238	7	in	in	IN
cord-007084-4niom5mw	238	8	the	the	DT
cord-007084-4niom5mw	238	9	adrenal	adrenal	JJ
cord-007084-4niom5mw	238	10	cortex	cortex	NN
cord-007084-4niom5mw	238	11	Topological	topological	JJ
cord-007084-4niom5mw	238	12	studies	study	NNS
cord-007084-4niom5mw	238	13	of	of	IN
cord-007084-4niom5mw	238	14	the	the	DT
cord-007084-4niom5mw	238	15	steroid	steroid	JJ
cord-007084-4niom5mw	238	16	hydroxylase	hydroxylase	NN
cord-007084-4niom5mw	238	17	complexes	complex	NNS
cord-007084-4niom5mw	238	18	in	in	IN
cord-007084-4niom5mw	238	19	bovine	bovine	JJ
cord-007084-4niom5mw	238	20	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	238	21	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	239	1	The	the	DT
cord-007084-4niom5mw	239	2	carbon	carbon	NN
cord-007084-4niom5mw	239	3	-	-	HYPH
cord-007084-4niom5mw	239	4	monoxide	monoxide	NN
cord-007084-4niom5mw	239	5	binding	binding	NN
cord-007084-4niom5mw	239	6	pigment	pigment	NN
cord-007084-4niom5mw	239	7	of	of	IN
cord-007084-4niom5mw	239	8	liver	liver	NN
cord-007084-4niom5mw	239	9	microsomes	microsome	NNS
cord-007084-4niom5mw	239	10	.	.	.
cord-007084-4niom5mw	240	1	I.	I.	NNP
cord-007084-4niom5mw	240	2	Evidence	evidence	NN
cord-007084-4niom5mw	240	3	for	for	IN
cord-007084-4niom5mw	240	4	its	-PRON-	PRP$
cord-007084-4niom5mw	240	5	homoprotein	homoprotein	NNP
cord-007084-4niom5mw	240	6	nature	nature	NN
cord-007084-4niom5mw	240	7	Biochemistry	Biochemistry	NNP
cord-007084-4niom5mw	240	8	of	of	IN
cord-007084-4niom5mw	240	9	dystrophic	dystrophic	JJ
cord-007084-4niom5mw	240	10	muscle	muscle	NN
cord-007084-4niom5mw	240	11	:	:	:
cord-007084-4niom5mw	241	1	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	241	2	succiniate	succiniate	NNP
cord-007084-4niom5mw	241	3	tetrazolium	tetrazolium	NNP
cord-007084-4niom5mw	241	4	reductase	reductase	NN
cord-007084-4niom5mw	241	5	and	and	CC
cord-007084-4niom5mw	241	6	adenosine	adenosine	NN
cord-007084-4niom5mw	241	7	triphosphatase	triphosphatase	NN
cord-007084-4niom5mw	241	8	Malic	malic	JJ
cord-007084-4niom5mw	241	9	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	241	10	from	from	IN
cord-007084-4niom5mw	241	11	pig	pig	NN
cord-007084-4niom5mw	241	12	heart	heart	NN
cord-007084-4niom5mw	241	13	Protein	Protein	NNP
cord-007084-4niom5mw	241	14	kinase	kinase	VBZ
cord-007084-4niom5mw	241	15	activity	activity	NN
cord-007084-4niom5mw	241	16	at	at	IN
cord-007084-4niom5mw	241	17	the	the	DT
cord-007084-4niom5mw	241	18	inner	inner	JJ
cord-007084-4niom5mw	241	19	membrane	membrane	NN
cord-007084-4niom5mw	241	20	of	of	IN
cord-007084-4niom5mw	241	21	mammalian	mammalian	JJ
cord-007084-4niom5mw	241	22	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	241	23	Microdetermination	Microdetermination	NNP
cord-007084-4niom5mw	241	24	of	of	IN
cord-007084-4niom5mw	241	25	monoamine	monoamine	NN
cord-007084-4niom5mw	241	26	oxidase	oxidase	NN
cord-007084-4niom5mw	241	27	and	and	CC
cord-007084-4niom5mw	241	28	5-hydroxytryptophan	5-hydroxytryptophan	CD
cord-007084-4niom5mw	241	29	decarboxylase	decarboxylase	NN
cord-007084-4niom5mw	241	30	activities	activity	NNS
cord-007084-4niom5mw	241	31	in	in	IN
cord-007084-4niom5mw	241	32	nervous	nervous	JJ
cord-007084-4niom5mw	241	33	tissues	tissue	NNS
cord-007084-4niom5mw	242	1	An	an	DT
cord-007084-4niom5mw	242	2	electron	electron	NN
cord-007084-4niom5mw	242	3	-	-	HYPH
cord-007084-4niom5mw	242	4	transport	transport	NN
cord-007084-4niom5mw	242	5	system	system	NN
cord-007084-4niom5mw	242	6	associated	associate	VBN
cord-007084-4niom5mw	242	7	with	with	IN
cord-007084-4niom5mw	242	8	the	the	DT
cord-007084-4niom5mw	242	9	outer	outer	JJ
cord-007084-4niom5mw	242	10	membrane	membrane	NN
cord-007084-4niom5mw	242	11	of	of	IN
cord-007084-4niom5mw	242	12	liver	liver	NN
cord-007084-4niom5mw	242	13	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	242	14	:	:	:
cord-007084-4niom5mw	242	15	a	a	DT
cord-007084-4niom5mw	242	16	biochemical	biochemical	JJ
cord-007084-4niom5mw	242	17	and	and	CC
cord-007084-4niom5mw	242	18	morphological	morphological	JJ
cord-007084-4niom5mw	242	19	study	study	NN
cord-007084-4niom5mw	242	20	Regulation	regulation	NN
cord-007084-4niom5mw	242	21	of	of	IN
cord-007084-4niom5mw	242	22	intramitochondrial	intramitochondrial	JJ
cord-007084-4niom5mw	242	23	cholesterol	cholesterol	NN
cord-007084-4niom5mw	242	24	transfer	transfer	NN
cord-007084-4niom5mw	242	25	to	to	IN
cord-007084-4niom5mw	242	26	side	side	NN
cord-007084-4niom5mw	242	27	-	-	HYPH
cord-007084-4niom5mw	242	28	chain	chain	NN
cord-007084-4niom5mw	242	29	cleavage	cleavage	NN
cord-007084-4niom5mw	242	30	cytochrome	cytochrome	NN
cord-007084-4niom5mw	242	31	P-450	p-450	XX
cord-007084-4niom5mw	242	32	in	in	IN
cord-007084-4niom5mw	242	33	rat	rat	NN
cord-007084-4niom5mw	242	34	adrenal	adrenal	JJ
cord-007084-4niom5mw	242	35	gland	gland	NN
cord-007084-4niom5mw	243	1	A	a	DT
cord-007084-4niom5mw	243	2	microspectrophotometric	microspectrophotometric	JJ
cord-007084-4niom5mw	243	3	method	method	NN
cord-007084-4niom5mw	243	4	for	for	IN
cord-007084-4niom5mw	243	5	the	the	DT
cord-007084-4niom5mw	243	6	determination	determination	NN
cord-007084-4niom5mw	243	7	of	of	IN
cord-007084-4niom5mw	243	8	cytochrome	cytochrome	NN
cord-007084-4niom5mw	243	9	oxidase	oxidase	NN
cord-007084-4niom5mw	243	10	Protein	Protein	NNP
cord-007084-4niom5mw	243	11	measurement	measurement	NN
cord-007084-4niom5mw	243	12	with	with	IN
cord-007084-4niom5mw	243	13	the	the	DT
cord-007084-4niom5mw	243	14	Folin	Folin	NNP
cord-007084-4niom5mw	243	15	phenol	phenol	NN
cord-007084-4niom5mw	243	16	reagent	reagent	NN
cord-007084-4niom5mw	243	17	A	a	DT
cord-007084-4niom5mw	243	18	modification	modification	NN
cord-007084-4niom5mw	243	19	of	of	IN
cord-007084-4niom5mw	243	20	the	the	DT
cord-007084-4niom5mw	243	21	Lowry	Lowry	NNP
cord-007084-4niom5mw	243	22	procedure	procedure	NN
cord-007084-4niom5mw	243	23	to	to	TO
cord-007084-4niom5mw	243	24	simplify	simplify	VB
cord-007084-4niom5mw	243	25	protein	protein	NN
cord-007084-4niom5mw	243	26	determination	determination	NN
cord-007084-4niom5mw	243	27	in	in	IN
cord-007084-4niom5mw	243	28	membrane	membrane	NN
cord-007084-4niom5mw	243	29	and	and	CC
cord-007084-4niom5mw	243	30	lipoprotein	lipoprotein	NN
cord-007084-4niom5mw	243	31	samples	sample	NNS
cord-007084-4niom5mw	244	1	The	the	DT
cord-007084-4niom5mw	244	2	submitochondrial	submitochondrial	JJ
cord-007084-4niom5mw	244	3	localization	localization	NN
cord-007084-4niom5mw	244	4	of	of	IN
cord-007084-4niom5mw	244	5	monoamine	monoamine	NN
cord-007084-4niom5mw	244	6	oxidase	oxidase	NN
cord-007084-4niom5mw	244	7	-	-	HYPH
cord-007084-4niom5mw	244	8	enzymatic	enzymatic	JJ
cord-007084-4niom5mw	244	9	marker	marker	NN
cord-007084-4niom5mw	244	10	for	for	IN
cord-007084-4niom5mw	244	11	the	the	DT
cord-007084-4niom5mw	244	12	outer	outer	JJ
cord-007084-4niom5mw	244	13	membrane	membrane	NN
cord-007084-4niom5mw	244	14	of	of	IN
cord-007084-4niom5mw	244	15	rat	rat	NN
cord-007084-4niom5mw	244	16	liver	liver	NN
cord-007084-4niom5mw	244	17	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	244	18	Utilization	utilization	NN
cord-007084-4niom5mw	244	19	of	of	IN
cord-007084-4niom5mw	244	20	intramitochondrial	intramitochondrial	NN
cord-007084-4niom5mw	244	21	membrane	membrane	NN
cord-007084-4niom5mw	244	22	cholesterol	cholesterol	NN
cord-007084-4niom5mw	244	23	by	by	IN
cord-007084-4niom5mw	244	24	cytochrome	cytochrome	NN
cord-007084-4niom5mw	244	25	P-450	P-450	VBD
cord-007084-4niom5mw	244	26	dependent	dependent	JJ
cord-007084-4niom5mw	244	27	cholesterol	cholesterol	NN
cord-007084-4niom5mw	244	28	side	side	NN
cord-007084-4niom5mw	244	29	-	-	HYPH
cord-007084-4niom5mw	244	30	chain	chain	NN
cord-007084-4niom5mw	244	31	cleavage	cleavage	NN
cord-007084-4niom5mw	244	32	reaction	reaction	NN
cord-007084-4niom5mw	244	33	in	in	IN
cord-007084-4niom5mw	244	34	bovine	bovine	JJ
cord-007084-4niom5mw	244	35	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	244	36	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	244	37	:	:	:
cord-007084-4niom5mw	244	38	steroidogenic	steroidogenic	NNP
cord-007084-4niom5mw	244	39	and	and	CC
cord-007084-4niom5mw	244	40	non	non	JJ
cord-007084-4niom5mw	244	41	-	-	JJ
cord-007084-4niom5mw	244	42	steroidogenic	steroidogenic	JJ
cord-007084-4niom5mw	244	43	pools	pool	NNS
cord-007084-4niom5mw	244	44	of	of	IN
cord-007084-4niom5mw	244	45	cholesterol	cholesterol	NN
cord-007084-4niom5mw	244	46	in	in	IN
cord-007084-4niom5mw	244	47	the	the	DT
cord-007084-4niom5mw	244	48	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	244	49	inner	inner	JJ
cord-007084-4niom5mw	244	50	membranes	membrane	NNS
cord-007084-4niom5mw	244	51	Localization	Localization	NNP
cord-007084-4niom5mw	244	52	of	of	IN
cord-007084-4niom5mw	244	53	L	l	NN
cord-007084-4niom5mw	244	54	-	-	HYPH
cord-007084-4niom5mw	244	55	lactate	lactate	NN
cord-007084-4niom5mw	244	56	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	244	57	in	in	IN
cord-007084-4niom5mw	244	58	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	244	59	Aging	age	VBG
cord-007084-4niom5mw	244	60	of	of	IN
cord-007084-4niom5mw	244	61	the	the	DT
cord-007084-4niom5mw	244	62	rat	rat	NN
cord-007084-4niom5mw	244	63	adrenocortical	adrenocortical	JJ
cord-007084-4niom5mw	244	64	cells	cell	NNS
cord-007084-4niom5mw	244	65	:	:	:
cord-007084-4niom5mw	244	66	response	response	NN
cord-007084-4niom5mw	244	67	to	to	IN
cord-007084-4niom5mw	244	68	ACTH	ACTH	NNP
cord-007084-4niom5mw	244	69	and	and	CC
cord-007084-4niom5mw	244	70	cyclic	cyclic	JJ
cord-007084-4niom5mw	244	71	AMP	amp	NN
cord-007084-4niom5mw	244	72	in	in	IN
cord-007084-4niom5mw	244	73	vitro	vitro	FW
cord-007084-4niom5mw	245	1	The	the	DT
cord-007084-4niom5mw	245	2	neuroendocrinology	neuroendocrinology	NN
cord-007084-4niom5mw	245	3	of	of	IN
cord-007084-4niom5mw	245	4	stress	stress	NN
cord-007084-4niom5mw	245	5	and	and	CC
cord-007084-4niom5mw	245	6	aging	aging	NN
cord-007084-4niom5mw	245	7	:	:	:
cord-007084-4niom5mw	245	8	The	the	DT
cord-007084-4niom5mw	245	9	glucocorticoid	glucocorticoid	NN
cord-007084-4niom5mw	245	10	cascade	cascade	NN
cord-007084-4niom5mw	245	11	hypothesis	hypothesis	NN
cord-007084-4niom5mw	245	12	Cytochrome	cytochrome	NN
cord-007084-4niom5mw	245	13	P-450	p-450	NN
cord-007084-4niom5mw	245	14	of	of	IN
cord-007084-4niom5mw	245	15	adrenal	adrenal	JJ
cord-007084-4niom5mw	245	16	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	245	17	:	:	:
cord-007084-4niom5mw	245	18	steroid	steroid	NN
cord-007084-4niom5mw	245	19	binding	bind	VBG
cord-007084-4niom5mw	245	20	sites	site	NNS
cord-007084-4niom5mw	245	21	of	of	IN
cord-007084-4niom5mw	245	22	two	two	CD
cord-007084-4niom5mw	245	23	distinguishable	distinguishable	JJ
cord-007084-4niom5mw	245	24	forms	form	NNS
cord-007084-4niom5mw	245	25	of	of	IN
cord-007084-4niom5mw	245	26	rat	rat	NN
cord-007084-4niom5mw	245	27	adrenal	adrenal	JJ
cord-007084-4niom5mw	245	28	mitochondrial	mitochondrial	NN
cord-007084-4niom5mw	245	29	cytochrome	cytochrome	NN
cord-007084-4niom5mw	245	30	P-4508c	p-4508c	NN
cord-007084-4niom5mw	245	31	C	C	NNP
cord-007084-4niom5mw	245	32	Evidence	evidence	NN
cord-007084-4niom5mw	245	33	suggesting	suggest	VBG
cord-007084-4niom5mw	245	34	that	that	IN
cord-007084-4niom5mw	245	35	more	more	JJR
cord-007084-4niom5mw	245	36	than	than	IN
cord-007084-4niom5mw	245	37	one	one	CD
cord-007084-4niom5mw	245	38	sterol	sterol	NN
cord-007084-4niom5mw	245	39	side	side	NN
cord-007084-4niom5mw	245	40	chain	chain	NN
cord-007084-4niom5mw	245	41	cleavage	cleavage	NN
cord-007084-4niom5mw	245	42	system	system	NN
cord-007084-4niom5mw	245	43	exists	exist	VBZ
cord-007084-4niom5mw	245	44	in	in	IN
cord-007084-4niom5mw	245	45	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	245	46	from	from	IN
cord-007084-4niom5mw	245	47	bovine	bovine	JJ
cord-007084-4niom5mw	245	48	adrenal	adrenal	JJ
cord-007084-4niom5mw	245	49	cortex	cortex	NNS
cord-007084-4niom5mw	245	50	Effects	effect	NNS
cord-007084-4niom5mw	245	51	of	of	IN
cord-007084-4niom5mw	245	52	phospholipid	phospholipid	NN
cord-007084-4niom5mw	245	53	and	and	CC
cord-007084-4niom5mw	245	54	detergent	detergent	NN
cord-007084-4niom5mw	245	55	on	on	IN
cord-007084-4niom5mw	245	56	the	the	DT
cord-007084-4niom5mw	245	57	substrate	substrate	JJ
cord-007084-4niom5mw	245	58	specificity	specificity	NN
cord-007084-4niom5mw	245	59	of	of	IN
cord-007084-4niom5mw	245	60	adrenal	adrenal	JJ
cord-007084-4niom5mw	245	61	cytochrome	cytochrome	NN
cord-007084-4niom5mw	245	62	P-450SCC	P-450SCC	NNP
cord-007084-4niom5mw	245	63	:	:	:
cord-007084-4niom5mw	245	64	substrate	substrate	NN
cord-007084-4niom5mw	245	65	binding	binding	NN
cord-007084-4niom5mw	245	66	and	and	CC
cord-007084-4niom5mw	245	67	kinetics	kinetic	NNS
cord-007084-4niom5mw	245	68	of	of	IN
cord-007084-4niom5mw	245	69	cholesterol	cholesterol	NN
cord-007084-4niom5mw	245	70	side	side	NN
cord-007084-4niom5mw	245	71	-	-	HYPH
cord-007084-4niom5mw	245	72	chain	chain	NN
cord-007084-4niom5mw	245	73	oxidation	oxidation	NN
cord-007084-4niom5mw	245	74	Purification	purification	NN
cord-007084-4niom5mw	245	75	and	and	CC
cord-007084-4niom5mw	245	76	characterization	characterization	NN
cord-007084-4niom5mw	245	77	of	of	IN
cord-007084-4niom5mw	245	78	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	245	79	cytochrome	cytochrome	NN
cord-007084-4niom5mw	245	80	P-450	p-450	NN
cord-007084-4niom5mw	245	81	associated	associate	VBN
cord-007084-4niom5mw	245	82	with	with	IN
cord-007084-4niom5mw	245	83	cholesterol	cholesterol	NN
cord-007084-4niom5mw	245	84	side	side	NN
cord-007084-4niom5mw	245	85	-	-	HYPH
cord-007084-4niom5mw	245	86	chain	chain	NN
cord-007084-4niom5mw	245	87	cleavage	cleavage	NN
cord-007084-4niom5mw	245	88	from	from	IN
cord-007084-4niom5mw	245	89	bovine	bovine	JJ
cord-007084-4niom5mw	245	90	corpus	corpus	NNP
cord-007084-4niom5mw	245	91	luteum	luteum	NN
cord-007084-4niom5mw	245	92	Inhibition	Inhibition	NNP
cord-007084-4niom5mw	245	93	of	of	IN
cord-007084-4niom5mw	245	94	cholesterol	cholesterol	NN
cord-007084-4niom5mw	245	95	side	side	NN
cord-007084-4niom5mw	245	96	chain	chain	NN
cord-007084-4niom5mw	245	97	cleavage	cleavage	NN
cord-007084-4niom5mw	245	98	by	by	IN
cord-007084-4niom5mw	245	99	active	active	JJ
cord-007084-4niom5mw	245	100	site	site	NN
cord-007084-4niom5mw	245	101	directed	direct	VBN
cord-007084-4niom5mw	245	102	antibody	antibody	NN
cord-007084-4niom5mw	245	103	to	to	IN
cord-007084-4niom5mw	245	104	corpus	corpus	NNP
cord-007084-4niom5mw	245	105	luteum	luteum	NN
cord-007084-4niom5mw	245	106	cytochrome	cytochrome	NN
cord-007084-4niom5mw	245	107	P450	P450	NNP
cord-007084-4niom5mw	246	1	The	the	DT
cord-007084-4niom5mw	246	2	differential	differential	JJ
cord-007084-4niom5mw	246	3	development	development	NN
cord-007084-4niom5mw	246	4	of	of	IN
cord-007084-4niom5mw	246	5	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	246	6	cytochrome	cytochrome	NN
cord-007084-4niom5mw	246	7	P-450	p-450	NN
cord-007084-4niom5mw	246	8	and	and	CC
cord-007084-4niom5mw	246	9	the	the	DT
cord-007084-4niom5mw	246	10	respiratory	respiratory	JJ
cord-007084-4niom5mw	246	11	cytochromes	cytochrome	NNS
cord-007084-4niom5mw	246	12	in	in	IN
cord-007084-4niom5mw	246	13	rat	rat	NN
cord-007084-4niom5mw	246	14	ovary	ovary	NN
cord-007084-4niom5mw	246	15	Intracellular	Intracellular	NNP
cord-007084-4niom5mw	246	16	movement	movement	NN
cord-007084-4niom5mw	246	17	of	of	IN
cord-007084-4niom5mw	246	18	cholesterol	cholesterol	NN
cord-007084-4niom5mw	246	19	in	in	IN
cord-007084-4niom5mw	246	20	rat	rat	NN
cord-007084-4niom5mw	246	21	adrenal	adrenal	JJ
cord-007084-4niom5mw	246	22	cells	cell	NNS
cord-007084-4niom5mw	246	23	:	:	:
cord-007084-4niom5mw	246	24	kinetics	kinetic	NNS
cord-007084-4niom5mw	246	25	and	and	CC
cord-007084-4niom5mw	246	26	effects	effect	NNS
cord-007084-4niom5mw	246	27	of	of	IN
cord-007084-4niom5mw	246	28	inhibitors	inhibitor	NNS
cord-007084-4niom5mw	247	1	On	on	IN
cord-007084-4niom5mw	247	2	the	the	DT
cord-007084-4niom5mw	247	3	mechanism	mechanism	NN
cord-007084-4niom5mw	247	4	whereby	whereby	WRB
cord-007084-4niom5mw	247	5	ACTH	ACTH	NNP
cord-007084-4niom5mw	247	6	and	and	CC
cord-007084-4niom5mw	247	7	cyclic	cyclic	JJ
cord-007084-4niom5mw	247	8	AMP	AMP	NNP
cord-007084-4niom5mw	247	9	increase	increase	NN
cord-007084-4niom5mw	247	10	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	11	polyphosphoinositides	polyphosphoinositide	NNS
cord-007084-4niom5mw	247	12	:	:	:
cord-007084-4niom5mw	247	13	rapid	rapid	JJ
cord-007084-4niom5mw	247	14	stimulation	stimulation	NN
cord-007084-4niom5mw	247	15	of	of	IN
cord-007084-4niom5mw	247	16	the	the	DT
cord-007084-4niom5mw	247	17	synthesis	synthesis	NN
cord-007084-4niom5mw	247	18	of	of	IN
cord-007084-4niom5mw	247	19	phosphatidic	phosphatidic	JJ
cord-007084-4niom5mw	247	20	acid	acid	NN
cord-007084-4niom5mw	247	21	and	and	CC
cord-007084-4niom5mw	247	22	derivatives	derivative	NNS
cord-007084-4niom5mw	247	23	of	of	IN
cord-007084-4niom5mw	247	24	CDP	CDP	NNP
cord-007084-4niom5mw	247	25	~	~	NFP
cord-007084-4niom5mw	247	26	diacylglycerol	diacylglycerol	NN
cord-007084-4niom5mw	247	27	Phosphoinositide	Phosphoinositide	NNP
cord-007084-4niom5mw	247	28	metabolism	metabolism	NN
cord-007084-4niom5mw	247	29	and	and	CC
cord-007084-4niom5mw	247	30	hormone	hormone	NN
cord-007084-4niom5mw	247	31	action	action	NN
cord-007084-4niom5mw	247	32	Adrenocorticotropic	Adrenocorticotropic	NNP
cord-007084-4niom5mw	247	33	hormone	hormone	NN
cord-007084-4niom5mw	247	34	-	-	HYPH
cord-007084-4niom5mw	247	35	mediated	mediate	VBN
cord-007084-4niom5mw	247	36	changes	change	NNS
cord-007084-4niom5mw	247	37	in	in	IN
cord-007084-4niom5mw	247	38	rat	rat	NN
cord-007084-4niom5mw	247	39	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	40	mitochondrial	mitochondrial	NN
cord-007084-4niom5mw	247	41	phospholipids	phospholipid	NNS
cord-007084-4niom5mw	247	42	Sterol	Sterol	NNP
cord-007084-4niom5mw	247	43	carrier	carrier	NN
cord-007084-4niom5mw	247	44	protein	protein	NN
cord-007084-4niom5mw	247	45	2	2	CD
cord-007084-4niom5mw	247	46	:	:	:
cord-007084-4niom5mw	247	47	delivery	delivery	NN
cord-007084-4niom5mw	247	48	of	of	IN
cord-007084-4niom5mw	247	49	cholesterol	cholesterol	NN
cord-007084-4niom5mw	247	50	from	from	IN
cord-007084-4niom5mw	247	51	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	52	lipid	lipid	NN
cord-007084-4niom5mw	247	53	droplets	droplet	NNS
cord-007084-4niom5mw	247	54	to	to	IN
cord-007084-4niom5mw	247	55	mitochondria	mitochondrion	NNS
cord-007084-4niom5mw	247	56	for	for	IN
cord-007084-4niom5mw	247	57	pregnenolone	pregnenolone	NN
cord-007084-4niom5mw	247	58	synthesis	synthesis	NN
cord-007084-4niom5mw	247	59	Sterol	Sterol	NNP
cord-007084-4niom5mw	247	60	carrier	carrier	NN
cord-007084-4niom5mw	247	61	protein	protein	NN
cord-007084-4niom5mw	247	62	2	2	CD
cord-007084-4niom5mw	247	63	:	:	:
cord-007084-4niom5mw	247	64	identification	identification	NN
cord-007084-4niom5mw	247	65	of	of	IN
cord-007084-4niom5mw	247	66	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	67	sterol	sterol	NN
cord-007084-4niom5mw	247	68	carrier	carrier	NN
cord-007084-4niom5mw	247	69	protein	protein	NN
cord-007084-4niom5mw	247	70	2	2	CD
cord-007084-4niom5mw	247	71	and	and	CC
cord-007084-4niom5mw	247	72	site	site	NN
cord-007084-4niom5mw	247	73	of	of	IN
cord-007084-4niom5mw	247	74	action	action	NN
cord-007084-4niom5mw	247	75	for	for	IN
cord-007084-4niom5mw	247	76	mitochondrial	mitochondrial	JJ
cord-007084-4niom5mw	247	77	cholesterol	cholesterol	NN
cord-007084-4niom5mw	247	78	utilization	utilization	NN
cord-007084-4niom5mw	247	79	Intramitochondrial	Intramitochondrial	NNP
cord-007084-4niom5mw	247	80	movement	movement	NN
cord-007084-4niom5mw	247	81	of	of	IN
cord-007084-4niom5mw	247	82	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	83	sterol	sterol	NN
cord-007084-4niom5mw	247	84	carrier	carrier	NN
cord-007084-4niom5mw	247	85	protein	protein	NN
cord-007084-4niom5mw	247	86	with	with	IN
cord-007084-4niom5mw	247	87	cholesterol	cholesterol	NN
cord-007084-4niom5mw	247	88	in	in	IN
cord-007084-4niom5mw	247	89	response	response	NN
cord-007084-4niom5mw	247	90	to	to	IN
cord-007084-4niom5mw	247	91	corticotropin	corticotropin	NNP
cord-007084-4niom5mw	247	92	Scallen	Scallen	NNP
cord-007084-4niom5mw	247	93	TJ	TJ	NNP
cord-007084-4niom5mw	247	94	1985	1985	CD
cord-007084-4niom5mw	247	95	Phospholipid	Phospholipid	NNP
cord-007084-4niom5mw	247	96	,	,	,
cord-007084-4niom5mw	247	97	sterol	sterol	NN
cord-007084-4niom5mw	247	98	carrier	carrier	NN
cord-007084-4niom5mw	247	99	protein	protein	NN
cord-007084-4niom5mw	247	100	2	2	CD
cord-007084-4niom5mw	247	101	and	and	CC
cord-007084-4niom5mw	247	102	adrenal	adrenal	JJ
cord-007084-4niom5mw	247	103	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	247	104	Polyphosphoinositide	Polyphosphoinositide	NNP
cord-007084-4niom5mw	247	105	activation	activation	NN
cord-007084-4niom5mw	247	106	of	of	IN
cord-007084-4niom5mw	247	107	cholesterol	cholesterol	NN
cord-007084-4niom5mw	247	108	side	side	NN
cord-007084-4niom5mw	247	109	chain	chain	NN
cord-007084-4niom5mw	247	110	cleavage	cleavage	NN
cord-007084-4niom5mw	247	111	with	with	IN
cord-007084-4niom5mw	247	112	purified	purify	VBN
cord-007084-4niom5mw	247	113	cytochrome	cytochrome	NN
cord-007084-4niom5mw	247	114	P-4508CC	P-4508CC	NNP
cord-007084-4niom5mw	247	115	Brownie	Brownie	NNP
cord-007084-4niom5mw	247	116	AC	AC	NNP
cord-007084-4niom5mw	247	117	i983	i983	NN
cord-007084-4niom5mw	248	1	Cholesterol	cholesterol	NN
cord-007084-4niom5mw	248	2	side	side	NN
cord-007084-4niom5mw	248	3	-	-	HYPH
cord-007084-4niom5mw	248	4	chain	chain	NN
cord-007084-4niom5mw	248	5	cleavage	cleavage	NN
cord-007084-4niom5mw	248	6	in	in	IN
cord-007084-4niom5mw	248	7	the	the	DT
cord-007084-4niom5mw	248	8	rat	rat	NN
cord-007084-4niom5mw	248	9	adrenal	adrenal	JJ
cord-007084-4niom5mw	248	10	cortex	cortex	NN
cord-007084-4niom5mw	248	11	:	:	:
cord-007084-4niom5mw	248	12	isolation	isolation	NN
cord-007084-4niom5mw	248	13	of	of	IN
cord-007084-4niom5mw	248	14	a	a	DT
cord-007084-4niom5mw	248	15	cycloheximide	cycloheximide	NN
cord-007084-4niom5mw	248	16	-	-	HYPH
cord-007084-4niom5mw	248	17	sensitive	sensitive	JJ
cord-007084-4niom5mw	248	18	activator	activator	NN
cord-007084-4niom5mw	248	19	peptide	peptide	NN
cord-007084-4niom5mw	248	20	Modulation	modulation	NN
cord-007084-4niom5mw	248	21	of	of	IN
cord-007084-4niom5mw	248	22	the	the	DT
cord-007084-4niom5mw	248	23	kinetics	kinetic	NNS
cord-007084-4niom5mw	248	24	of	of	IN
cord-007084-4niom5mw	248	25	cholesterol	cholesterol	NN
cord-007084-4niom5mw	248	26	side	side	NN
cord-007084-4niom5mw	248	27	-	-	HYPH
cord-007084-4niom5mw	248	28	chain	chain	NN
cord-007084-4niom5mw	248	29	cleavage	cleavage	NN
cord-007084-4niom5mw	248	30	by	by	IN
cord-007084-4niom5mw	248	31	an	an	DT
cord-007084-4niom5mw	248	32	activator	activator	NN
cord-007084-4niom5mw	248	33	and	and	CC
cord-007084-4niom5mw	248	34	by	by	IN
cord-007084-4niom5mw	248	35	an	an	DT
cord-007084-4niom5mw	248	36	inhibitor	inhibitor	NN
cord-007084-4niom5mw	248	37	isolated	isolate	VBN
cord-007084-4niom5mw	248	38	from	from	IN
cord-007084-4niom5mw	248	39	the	the	DT
cord-007084-4niom5mw	248	40	cytosol	cytosol	NN
cord-007084-4niom5mw	248	41	of	of	IN
cord-007084-4niom5mw	248	42	the	the	DT
cord-007084-4niom5mw	248	43	cortex	cortex	NN
cord-007084-4niom5mw	248	44	of	of	IN
cord-007084-4niom5mw	248	45	bovine	bovine	NN
cord-007084-4niom5mw	248	46	.	.	.
cord-007084-4niom5mw	249	1	adrenals	adrenal	NNS
cord-007084-4niom5mw	249	2	Aging	age	VBG
cord-007084-4niom5mw	249	3	and	and	CC
cord-007084-4niom5mw	249	4	adrenal	adrenal	JJ
cord-007084-4niom5mw	250	1	A	a	DT
cord-007084-4niom5mw	250	2	5	5	CD
cord-007084-4niom5mw	250	3	-3-/3-hydroxysteroid	-3-/3-hydroxysteroid	NN
cord-007084-4niom5mw	250	4	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	250	5	in	in	IN
cord-007084-4niom5mw	250	6	female	female	JJ
cord-007084-4niom5mw	250	7	mice	mouse	NNS
cord-007084-4niom5mw	250	8	Aging	age	VBG
cord-007084-4niom5mw	250	9	and	and	CC
cord-007084-4niom5mw	250	10	adrenal	adrenal	JJ
cord-007084-4niom5mw	251	1	A	a	DT
cord-007084-4niom5mw	251	2	6	6	CD
cord-007084-4niom5mw	251	3	-3/3-hydroxysteroid	-3/3-hydroxysteroid	JJ
cord-007084-4niom5mw	251	4	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	251	5	in	in	IN
cord-007084-4niom5mw	251	6	female	female	JJ
cord-007084-4niom5mw	251	7	rats	rat	NNS
cord-007084-4niom5mw	252	1	The	the	DT
cord-007084-4niom5mw	252	2	effect	effect	NN
cord-007084-4niom5mw	252	3	of	of	IN
cord-007084-4niom5mw	252	4	vasectomy	vasectomy	NN
cord-007084-4niom5mw	252	5	on	on	IN
cord-007084-4niom5mw	252	6	steroid	steroid	NN
cord-007084-4niom5mw	252	7	metabolism	metabolism	NN
cord-007084-4niom5mw	252	8	by	by	IN
cord-007084-4niom5mw	252	9	the	the	DT
cord-007084-4niom5mw	252	10	seminiferous	seminiferous	JJ
cord-007084-4niom5mw	252	11	tubules	tubule	NNS
cord-007084-4niom5mw	252	12	and	and	CC
cord-007084-4niom5mw	252	13	interstitial	interstitial	JJ
cord-007084-4niom5mw	252	14	tissue	tissue	NN
cord-007084-4niom5mw	252	15	of	of	IN
cord-007084-4niom5mw	252	16	the	the	DT
cord-007084-4niom5mw	252	17	rat	rat	NN
cord-007084-4niom5mw	252	18	testis	testis	NN
cord-007084-4niom5mw	252	19	:	:	:
cord-007084-4niom5mw	252	20	a	a	DT
cord-007084-4niom5mw	252	21	comparison	comparison	NN
cord-007084-4niom5mw	252	22	with	with	IN
cord-007084-4niom5mw	252	23	the	the	DT
cord-007084-4niom5mw	252	24	effects	effect	NNS
cord-007084-4niom5mw	252	25	of	of	IN
cord-007084-4niom5mw	252	26	aging	age	VBG
cord-007084-4niom5mw	252	27	Effect	effect	NN
cord-007084-4niom5mw	252	28	of	of	IN
cord-007084-4niom5mw	252	29	age	age	NN
cord-007084-4niom5mw	252	30	on	on	IN
cord-007084-4niom5mw	252	31	testis	testis	NN
cord-007084-4niom5mw	252	32	A	a	NN
cord-007084-4niom5mw	253	1	6	6	LS
cord-007084-4niom5mw	253	2	-3j8-hydroxysteroid	-3j8-hydroxysteroid	DT
cord-007084-4niom5mw	253	3	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	253	4	in	in	IN
cord-007084-4niom5mw	253	5	the	the	DT
cord-007084-4niom5mw	253	6	rat	rat	NN
cord-007084-4niom5mw	253	7	Testicular	Testicular	NNP
cord-007084-4niom5mw	253	8	function	function	NN
cord-007084-4niom5mw	253	9	and	and	CC
cord-007084-4niom5mw	253	10	sexual	sexual	JJ
cord-007084-4niom5mw	253	11	activity	activity	NN
cord-007084-4niom5mw	253	12	in	in	IN
cord-007084-4niom5mw	253	13	senescent	senescent	JJ
cord-007084-4niom5mw	253	14	mice	mouse	NNS
cord-007084-4niom5mw	254	1	Ovarian	ovarian	NN
cord-007084-4niom5mw	255	1	A	a	DT
cord-007084-4niom5mw	255	2	5	5	CD
cord-007084-4niom5mw	255	3	-3/3-hydroxysteroid	-3/3-hydroxysteroid	JJ
cord-007084-4niom5mw	255	4	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	255	5	in	in	IN
cord-007084-4niom5mw	255	6	aging	age	VBG
cord-007084-4niom5mw	255	7	rats	rat	NNS
cord-007084-4niom5mw	255	8	Aging	age	VBG
cord-007084-4niom5mw	255	9	and	and	CC
cord-007084-4niom5mw	255	10	ovarian	ovarian	NN
cord-007084-4niom5mw	255	11	A	a	NN
cord-007084-4niom5mw	255	12	5	5	CD
cord-007084-4niom5mw	256	1	-3j8	-3j8	:
cord-007084-4niom5mw	257	1	hydroxysteroid	hydroxysteroid	NNP
cord-007084-4niom5mw	257	2	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	257	3	in	in	IN
cord-007084-4niom5mw	257	4	rats	rat	NNS
cord-007084-4niom5mw	257	5	Aging	age	VBG
cord-007084-4niom5mw	257	6	and	and	CC
cord-007084-4niom5mw	257	7	ovarian	ovarian	NN
cord-007084-4niom5mw	258	1	A	a	DT
cord-007084-4niom5mw	258	2	5	5	CD
cord-007084-4niom5mw	258	3	-3/3-hydroxysteroid	-3/3-hydroxysteroid	JJ
cord-007084-4niom5mw	258	4	dehydrogenase	dehydrogenase	NN
cord-007084-4niom5mw	258	5	in	in	IN
cord-007084-4niom5mw	258	6	the	the	DT
cord-007084-4niom5mw	258	7	pregnant	pregnant	JJ
cord-007084-4niom5mw	258	8	mouse	mouse	NN
cord-007084-4niom5mw	259	1	An	an	DT
cord-007084-4niom5mw	259	2	analysis	analysis	NN
cord-007084-4niom5mw	259	3	of	of	IN
cord-007084-4niom5mw	259	4	the	the	DT
cord-007084-4niom5mw	259	5	age	age	NN
cord-007084-4niom5mw	259	6	-	-	HYPH
cord-007084-4niom5mw	259	7	related	relate	VBN
cord-007084-4niom5mw	259	8	decline	decline	NN
cord-007084-4niom5mw	259	9	in	in	IN
cord-007084-4niom5mw	259	10	testicular	testicular	JJ
cord-007084-4niom5mw	259	11	steroidogenesis	steroidogenesis	NN
cord-007084-4niom5mw	259	12	in	in	IN
cord-007084-4niom5mw	259	13	the	the	DT
cord-007084-4niom5mw	259	14	rat	rat	NN