id	sid	tid	token	lemma	pos
cord-018387-ci5wx26t	1	1	key	key	JJ
cord-018387-ci5wx26t	1	2	:	:	:
cord-018387-ci5wx26t	1	3	cord-018387-ci5wx26	cord-018387-ci5wx26	NNP
cord-018387-ci5wx26t	1	4	t	t	NNP
cord-018387-ci5wx26t	1	5	authors	author	NNS
cord-018387-ci5wx26t	1	6	:	:	:
cord-018387-ci5wx26t	1	7	Di	Di	NNP
cord-018387-ci5wx26t	1	8	Benedetto	Benedetto	NNP
cord-018387-ci5wx26t	1	9	,	,	,
cord-018387-ci5wx26t	1	10	Svetlana	Svetlana	NNP
cord-018387-ci5wx26t	1	11	;	;	:
cord-018387-ci5wx26t	1	12	Müller	Müller	NNP
cord-018387-ci5wx26t	1	13	,	,	,
cord-018387-ci5wx26t	2	1	Ludmila	Ludmila	NNP
cord-018387-ci5wx26t	2	2	title	title	NN
cord-018387-ci5wx26t	2	3	:	:	:
cord-018387-ci5wx26t	2	4	Aging	aging	NN
cord-018387-ci5wx26t	2	5	,	,	,
cord-018387-ci5wx26t	2	6	Immunity	Immunity	NNP
cord-018387-ci5wx26t	2	7	,	,	,
cord-018387-ci5wx26t	2	8	and	and	CC
cord-018387-ci5wx26t	2	9	Neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	2	10	:	:	:
cord-018387-ci5wx26t	3	1	The	the	DT
cord-018387-ci5wx26t	3	2	Modulatory	modulatory	JJ
cord-018387-ci5wx26t	3	3	Potential	potential	NN
cord-018387-ci5wx26t	3	4	of	of	IN
cord-018387-ci5wx26t	3	5	Nutrition	Nutrition	NNP
cord-018387-ci5wx26t	3	6	date	date	NN
cord-018387-ci5wx26t	3	7	:	:	:
cord-018387-ci5wx26t	3	8	2019	2019	CD
cord-018387-ci5wx26t	3	9	-	-	HYPH
cord-018387-ci5wx26t	3	10	07	07	CD
cord-018387-ci5wx26t	3	11	-	-	HYPH
cord-018387-ci5wx26t	3	12	31	31	CD
cord-018387-ci5wx26t	3	13	journal	journal	NN
cord-018387-ci5wx26t	3	14	:	:	:
cord-018387-ci5wx26t	3	15	Nutrition	Nutrition	NNP
cord-018387-ci5wx26t	3	16	and	and	CC
cord-018387-ci5wx26t	3	17	Immunity	Immunity	NNP
cord-018387-ci5wx26t	3	18	DOI	DOI	NNP
cord-018387-ci5wx26t	3	19	:	:	:
cord-018387-ci5wx26t	3	20	10.1007/978	10.1007/978	CD
cord-018387-ci5wx26t	3	21	-	-	HYPH
cord-018387-ci5wx26t	3	22	3	3	CD
cord-018387-ci5wx26t	3	23	-	-	HYPH
cord-018387-ci5wx26t	3	24	030	030	CD
cord-018387-ci5wx26t	3	25	-	-	HYPH
cord-018387-ci5wx26t	3	26	16073	16073	CD
cord-018387-ci5wx26t	3	27	-	-	HYPH
cord-018387-ci5wx26t	3	28	9_14	9_14	CD
cord-018387-ci5wx26t	3	29	sha	sha	NNP
cord-018387-ci5wx26t	3	30	:	:	:
cord-018387-ci5wx26t	3	31	19e02c46134425487becf1ff1750b38fd8b22bfd	19e02c46134425487becf1ff1750b38fd8b22bfd	CD
cord-018387-ci5wx26t	4	1	doc_id	doc_id	CD
cord-018387-ci5wx26t	5	1	:	:	:
cord-018387-ci5wx26t	5	2	18387	18387	CD
cord-018387-ci5wx26t	5	3	cord_uid	cord_uid	NNS
cord-018387-ci5wx26t	5	4	:	:	:
cord-018387-ci5wx26t	6	1	ci5wx26	ci5wx26	NNP
cord-018387-ci5wx26t	7	1	t	t	NNP
cord-018387-ci5wx26t	7	2	Aging	age	VBG
cord-018387-ci5wx26t	7	3	influences	influence	VBZ
cord-018387-ci5wx26t	7	4	an	an	DT
cord-018387-ci5wx26t	7	5	organism	organism	NN
cord-018387-ci5wx26t	7	6	’s	’s	POS
cord-018387-ci5wx26t	7	7	entire	entire	JJ
cord-018387-ci5wx26t	7	8	physiology	physiology	NN
cord-018387-ci5wx26t	7	9	,	,	,
cord-018387-ci5wx26t	7	10	affecting	affect	VBG
cord-018387-ci5wx26t	7	11	functions	function	NNS
cord-018387-ci5wx26t	7	12	at	at	IN
cord-018387-ci5wx26t	7	13	the	the	DT
cord-018387-ci5wx26t	7	14	molecular	molecular	JJ
cord-018387-ci5wx26t	7	15	,	,	,
cord-018387-ci5wx26t	7	16	cellular	cellular	JJ
cord-018387-ci5wx26t	7	17	,	,	,
cord-018387-ci5wx26t	7	18	and	and	CC
cord-018387-ci5wx26t	7	19	systemic	systemic	JJ
cord-018387-ci5wx26t	7	20	levels	level	NNS
cord-018387-ci5wx26t	7	21	and	and	CC
cord-018387-ci5wx26t	7	22	increasing	increase	VBG
cord-018387-ci5wx26t	7	23	susceptibility	susceptibility	NN
cord-018387-ci5wx26t	7	24	to	to	IN
cord-018387-ci5wx26t	7	25	many	many	JJ
cord-018387-ci5wx26t	7	26	major	major	JJ
cord-018387-ci5wx26t	7	27	chronic	chronic	JJ
cord-018387-ci5wx26t	7	28	diseases	disease	NNS
cord-018387-ci5wx26t	7	29	.	.	.
cord-018387-ci5wx26t	8	1	The	the	DT
cord-018387-ci5wx26t	8	2	changes	change	NNS
cord-018387-ci5wx26t	8	3	in	in	IN
cord-018387-ci5wx26t	8	4	the	the	DT
cord-018387-ci5wx26t	8	5	immune	immune	JJ
cord-018387-ci5wx26t	8	6	system	system	NN
cord-018387-ci5wx26t	8	7	that	that	WDT
cord-018387-ci5wx26t	8	8	accompany	accompany	VBP
cord-018387-ci5wx26t	8	9	human	human	JJ
cord-018387-ci5wx26t	8	10	aging	aging	NN
cord-018387-ci5wx26t	8	11	are	be	VBP
cord-018387-ci5wx26t	8	12	very	very	RB
cord-018387-ci5wx26t	8	13	complex	complex	JJ
cord-018387-ci5wx26t	8	14	and	and	CC
cord-018387-ci5wx26t	8	15	are	be	VBP
cord-018387-ci5wx26t	8	16	generally	generally	RB
cord-018387-ci5wx26t	8	17	referred	refer	VBN
cord-018387-ci5wx26t	8	18	to	to	IN
cord-018387-ci5wx26t	8	19	as	as	RB
cord-018387-ci5wx26t	8	20	immunosenescence	immunosenescence	NNP
cord-018387-ci5wx26t	8	21	.	.	.
cord-018387-ci5wx26t	9	1	The	the	DT
cord-018387-ci5wx26t	9	2	factors	factor	NNS
cord-018387-ci5wx26t	9	3	and	and	CC
cord-018387-ci5wx26t	9	4	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	9	5	of	of	IN
cord-018387-ci5wx26t	9	6	immunosenescence	immunosenescence	NNP
cord-018387-ci5wx26t	9	7	are	be	VBP
cord-018387-ci5wx26t	9	8	multiple	multiple	JJ
cord-018387-ci5wx26t	9	9	and	and	CC
cord-018387-ci5wx26t	9	10	include	include	VBP
cord-018387-ci5wx26t	9	11	,	,	,
cord-018387-ci5wx26t	9	12	among	among	IN
cord-018387-ci5wx26t	9	13	others	other	NNS
cord-018387-ci5wx26t	9	14	,	,	,
cord-018387-ci5wx26t	9	15	defects	defect	NNS
cord-018387-ci5wx26t	9	16	in	in	IN
cord-018387-ci5wx26t	9	17	the	the	DT
cord-018387-ci5wx26t	9	18	bone	bone	NN
cord-018387-ci5wx26t	9	19	marrow	marrow	NN
cord-018387-ci5wx26t	9	20	,	,	,
cord-018387-ci5wx26t	9	21	thymic	thymic	JJ
cord-018387-ci5wx26t	9	22	involution	involution	NN
cord-018387-ci5wx26t	9	23	,	,	,
cord-018387-ci5wx26t	9	24	and	and	CC
cord-018387-ci5wx26t	9	25	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	9	26	defects	defect	NNS
cord-018387-ci5wx26t	9	27	in	in	IN
cord-018387-ci5wx26t	9	28	the	the	DT
cord-018387-ci5wx26t	9	29	formation	formation	NN
cord-018387-ci5wx26t	9	30	,	,	,
cord-018387-ci5wx26t	9	31	maturation	maturation	NN
cord-018387-ci5wx26t	9	32	,	,	,
cord-018387-ci5wx26t	9	33	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	9	34	,	,	,
cord-018387-ci5wx26t	9	35	and	and	CC
cord-018387-ci5wx26t	9	36	migration	migration	NN
cord-018387-ci5wx26t	9	37	of	of	IN
cord-018387-ci5wx26t	9	38	peripheral	peripheral	JJ
cord-018387-ci5wx26t	9	39	lymphocytes	lymphocyte	NNS
cord-018387-ci5wx26t	9	40	.	.	.
cord-018387-ci5wx26t	10	1	Aging	aging	NN
cord-018387-ci5wx26t	10	2	affects	affect	VBZ
cord-018387-ci5wx26t	10	3	both	both	CC
cord-018387-ci5wx26t	10	4	the	the	DT
cord-018387-ci5wx26t	10	5	innate	innate	JJ
cord-018387-ci5wx26t	10	6	and	and	CC
cord-018387-ci5wx26t	10	7	adaptive	adaptive	JJ
cord-018387-ci5wx26t	10	8	arms	arm	NNS
cord-018387-ci5wx26t	10	9	of	of	IN
cord-018387-ci5wx26t	10	10	the	the	DT
cord-018387-ci5wx26t	10	11	immune	immune	JJ
cord-018387-ci5wx26t	10	12	system	system	NN
cord-018387-ci5wx26t	10	13	.	.	.
cord-018387-ci5wx26t	11	1	The	the	DT
cord-018387-ci5wx26t	11	2	process	process	NN
cord-018387-ci5wx26t	11	3	of	of	IN
cord-018387-ci5wx26t	11	4	aging	age	VBG
cord-018387-ci5wx26t	11	5	is	be	VBZ
cord-018387-ci5wx26t	11	6	commonly	commonly	RB
cord-018387-ci5wx26t	11	7	accompanied	accompany	VBN
cord-018387-ci5wx26t	11	8	by	by	IN
cord-018387-ci5wx26t	11	9	low	low	JJ
cord-018387-ci5wx26t	11	10	-	-	HYPH
cord-018387-ci5wx26t	11	11	grade	grade	NN
cord-018387-ci5wx26t	11	12	inflammation	inflammation	NN
cord-018387-ci5wx26t	11	13	thought	think	VBN
cord-018387-ci5wx26t	11	14	to	to	TO
cord-018387-ci5wx26t	11	15	contribute	contribute	VB
cord-018387-ci5wx26t	11	16	to	to	IN
cord-018387-ci5wx26t	11	17	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	11	18	and	and	CC
cord-018387-ci5wx26t	11	19	to	to	IN
cord-018387-ci5wx26t	11	20	many	many	JJ
cord-018387-ci5wx26t	11	21	age	age	NN
cord-018387-ci5wx26t	11	22	-	-	HYPH
cord-018387-ci5wx26t	11	23	related	relate	VBN
cord-018387-ci5wx26t	11	24	diseases	disease	NNS
cord-018387-ci5wx26t	11	25	.	.	.
cord-018387-ci5wx26t	12	1	Numerous	numerous	JJ
cord-018387-ci5wx26t	12	2	attempts	attempt	NNS
cord-018387-ci5wx26t	12	3	to	to	TO
cord-018387-ci5wx26t	12	4	define	define	VB
cord-018387-ci5wx26t	12	5	the	the	DT
cord-018387-ci5wx26t	12	6	role	role	NN
cord-018387-ci5wx26t	12	7	of	of	IN
cord-018387-ci5wx26t	12	8	chronic	chronic	JJ
cord-018387-ci5wx26t	12	9	inflammation	inflammation	NN
cord-018387-ci5wx26t	12	10	in	in	IN
cord-018387-ci5wx26t	12	11	aging	age	VBG
cord-018387-ci5wx26t	12	12	have	have	VBP
cord-018387-ci5wx26t	12	13	implicated	implicate	VBN
cord-018387-ci5wx26t	12	14	chronic	chronic	JJ
cord-018387-ci5wx26t	12	15	oxidative	oxidative	JJ
cord-018387-ci5wx26t	12	16	stress	stress	NN
cord-018387-ci5wx26t	12	17	,	,	,
cord-018387-ci5wx26t	12	18	mitochondrial	mitochondrial	JJ
cord-018387-ci5wx26t	12	19	damage	damage	NN
cord-018387-ci5wx26t	12	20	,	,	,
cord-018387-ci5wx26t	12	21	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	12	22	,	,	,
cord-018387-ci5wx26t	12	23	epigenetic	epigenetic	JJ
cord-018387-ci5wx26t	12	24	modifications	modification	NNS
cord-018387-ci5wx26t	12	25	,	,	,
cord-018387-ci5wx26t	12	26	and	and	CC
cord-018387-ci5wx26t	12	27	other	other	JJ
cord-018387-ci5wx26t	12	28	phenomena	phenomenon	NNS
cord-018387-ci5wx26t	12	29	.	.	.
cord-018387-ci5wx26t	13	1	Several	several	JJ
cord-018387-ci5wx26t	13	2	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	13	3	strategies	strategy	NNS
cord-018387-ci5wx26t	13	4	,	,	,
cord-018387-ci5wx26t	13	5	such	such	JJ
cord-018387-ci5wx26t	13	6	as	as	IN
cord-018387-ci5wx26t	13	7	intervening	intervene	VBG
cord-018387-ci5wx26t	13	8	to	to	TO
cord-018387-ci5wx26t	13	9	provide	provide	VB
cord-018387-ci5wx26t	13	10	an	an	DT
cord-018387-ci5wx26t	13	11	adequate	adequate	JJ
cord-018387-ci5wx26t	13	12	diet	diet	NN
cord-018387-ci5wx26t	13	13	and	and	CC
cord-018387-ci5wx26t	13	14	physical	physical	JJ
cord-018387-ci5wx26t	13	15	and	and	CC
cord-018387-ci5wx26t	13	16	mental	mental	JJ
cord-018387-ci5wx26t	13	17	activity	activity	NN
cord-018387-ci5wx26t	13	18	,	,	,
cord-018387-ci5wx26t	13	19	have	have	VBP
cord-018387-ci5wx26t	13	20	been	be	VBN
cord-018387-ci5wx26t	13	21	shown	show	VBN
cord-018387-ci5wx26t	13	22	to	to	TO
cord-018387-ci5wx26t	13	23	result	result	VB
cord-018387-ci5wx26t	13	24	in	in	IN
cord-018387-ci5wx26t	13	25	improved	improved	JJ
cord-018387-ci5wx26t	13	26	immune	immune	JJ
cord-018387-ci5wx26t	13	27	and	and	CC
cord-018387-ci5wx26t	13	28	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	13	29	functions	function	NNS
cord-018387-ci5wx26t	13	30	,	,	,
cord-018387-ci5wx26t	13	31	a	a	DT
cord-018387-ci5wx26t	13	32	decrease	decrease	NN
cord-018387-ci5wx26t	13	33	in	in	IN
cord-018387-ci5wx26t	13	34	oxidative	oxidative	JJ
cord-018387-ci5wx26t	13	35	stress	stress	NN
cord-018387-ci5wx26t	13	36	and	and	CC
cord-018387-ci5wx26t	13	37	inflammation	inflammation	NN
cord-018387-ci5wx26t	13	38	,	,	,
cord-018387-ci5wx26t	13	39	and	and	CC
cord-018387-ci5wx26t	13	40	a	a	DT
cord-018387-ci5wx26t	13	41	potential	potential	JJ
cord-018387-ci5wx26t	13	42	increase	increase	NN
cord-018387-ci5wx26t	13	43	in	in	IN
cord-018387-ci5wx26t	13	44	individual	individual	JJ
cord-018387-ci5wx26t	13	45	longevity	longevity	NN
cord-018387-ci5wx26t	13	46	.	.	.
cord-018387-ci5wx26t	14	1	The	the	DT
cord-018387-ci5wx26t	14	2	studies	study	NNS
cord-018387-ci5wx26t	14	3	published	publish	VBN
cord-018387-ci5wx26t	14	4	thus	thus	RB
cord-018387-ci5wx26t	14	5	far	far	RB
cord-018387-ci5wx26t	14	6	describe	describe	VBP
cord-018387-ci5wx26t	14	7	a	a	DT
cord-018387-ci5wx26t	14	8	critical	critical	JJ
cord-018387-ci5wx26t	14	9	role	role	NN
cord-018387-ci5wx26t	14	10	for	for	IN
cord-018387-ci5wx26t	14	11	nutrition	nutrition	NN
cord-018387-ci5wx26t	14	12	in	in	IN
cord-018387-ci5wx26t	14	13	maintaining	maintain	VBG
cord-018387-ci5wx26t	14	14	the	the	DT
cord-018387-ci5wx26t	14	15	immune	immune	JJ
cord-018387-ci5wx26t	14	16	response	response	NN
cord-018387-ci5wx26t	14	17	of	of	IN
cord-018387-ci5wx26t	14	18	the	the	DT
cord-018387-ci5wx26t	14	19	aged	aged	JJ
cord-018387-ci5wx26t	14	20	,	,	,
cord-018387-ci5wx26t	14	21	but	but	CC
cord-018387-ci5wx26t	14	22	they	-PRON-	PRP
cord-018387-ci5wx26t	14	23	also	also	RB
cord-018387-ci5wx26t	14	24	indicate	indicate	VBP
cord-018387-ci5wx26t	14	25	the	the	DT
cord-018387-ci5wx26t	14	26	need	need	NN
cord-018387-ci5wx26t	14	27	for	for	IN
cord-018387-ci5wx26t	14	28	a	a	DT
cord-018387-ci5wx26t	14	29	more	more	RBR
cord-018387-ci5wx26t	14	30	in	in	IN
cord-018387-ci5wx26t	14	31	-	-	HYPH
cord-018387-ci5wx26t	14	32	depth	depth	NN
cord-018387-ci5wx26t	14	33	,	,	,
cord-018387-ci5wx26t	14	34	holistic	holistic	JJ
cord-018387-ci5wx26t	14	35	approach	approach	NN
cord-018387-ci5wx26t	14	36	to	to	IN
cord-018387-ci5wx26t	14	37	determining	determine	VBG
cord-018387-ci5wx26t	14	38	the	the	DT
cord-018387-ci5wx26t	14	39	optimal	optimal	JJ
cord-018387-ci5wx26t	14	40	nutritional	nutritional	JJ
cord-018387-ci5wx26t	14	41	and	and	CC
cord-018387-ci5wx26t	14	42	behavioral	behavioral	JJ
cord-018387-ci5wx26t	14	43	strategies	strategy	NNS
cord-018387-ci5wx26t	14	44	that	that	WDT
cord-018387-ci5wx26t	14	45	would	would	MD
cord-018387-ci5wx26t	14	46	maintain	maintain	VB
cord-018387-ci5wx26t	14	47	immune	immune	JJ
cord-018387-ci5wx26t	14	48	and	and	CC
cord-018387-ci5wx26t	14	49	other	other	JJ
cord-018387-ci5wx26t	14	50	physiological	physiological	JJ
cord-018387-ci5wx26t	14	51	systems	system	NNS
cord-018387-ci5wx26t	14	52	in	in	IN
cord-018387-ci5wx26t	14	53	elderly	elderly	JJ
cord-018387-ci5wx26t	14	54	people	people	NNS
cord-018387-ci5wx26t	14	55	.	.	.
cord-018387-ci5wx26t	15	1	In	in	IN
cord-018387-ci5wx26t	15	2	this	this	DT
cord-018387-ci5wx26t	15	3	chapter	chapter	NN
cord-018387-ci5wx26t	15	4	,	,	,
cord-018387-ci5wx26t	15	5	we	-PRON-	PRP
cord-018387-ci5wx26t	15	6	focus	focus	VBP
cord-018387-ci5wx26t	15	7	first	first	RB
cord-018387-ci5wx26t	15	8	on	on	IN
cord-018387-ci5wx26t	15	9	the	the	DT
cord-018387-ci5wx26t	15	10	age	age	NN
cord-018387-ci5wx26t	15	11	-	-	HYPH
cord-018387-ci5wx26t	15	12	related	relate	VBN
cord-018387-ci5wx26t	15	13	changes	change	NNS
cord-018387-ci5wx26t	15	14	of	of	IN
cord-018387-ci5wx26t	15	15	the	the	DT
cord-018387-ci5wx26t	15	16	immune	immune	JJ
cord-018387-ci5wx26t	15	17	system	system	NN
cord-018387-ci5wx26t	15	18	.	.	.
cord-018387-ci5wx26t	16	1	Further	further	RB
cord-018387-ci5wx26t	16	2	,	,	,
cord-018387-ci5wx26t	16	3	we	-PRON-	PRP
cord-018387-ci5wx26t	16	4	discuss	discuss	VBP
cord-018387-ci5wx26t	16	5	possible	possible	JJ
cord-018387-ci5wx26t	16	6	deleterious	deleterious	JJ
cord-018387-ci5wx26t	16	7	influences	influence	NNS
cord-018387-ci5wx26t	16	8	of	of	IN
cord-018387-ci5wx26t	16	9	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	16	10	and	and	CC
cord-018387-ci5wx26t	16	11	low	low	JJ
cord-018387-ci5wx26t	16	12	-	-	HYPH
cord-018387-ci5wx26t	16	13	grade	grade	NN
cord-018387-ci5wx26t	16	14	inflammation	inflammation	NN
cord-018387-ci5wx26t	16	15	(	(	-LRB-
cord-018387-ci5wx26t	16	16	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	16	17	)	)	-RRB-
cord-018387-ci5wx26t	16	18	on	on	IN
cord-018387-ci5wx26t	16	19	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	16	20	processes	process	NNS
cord-018387-ci5wx26t	16	21	in	in	IN
cord-018387-ci5wx26t	16	22	the	the	DT
cord-018387-ci5wx26t	16	23	normally	normally	RB
cord-018387-ci5wx26t	16	24	aging	age	VBG
cord-018387-ci5wx26t	16	25	brain	brain	NN
cord-018387-ci5wx26t	16	26	.	.	.
cord-018387-ci5wx26t	17	1	Finally	finally	RB
cord-018387-ci5wx26t	17	2	,	,	,
cord-018387-ci5wx26t	17	3	we	-PRON-	PRP
cord-018387-ci5wx26t	17	4	consider	consider	VBP
cord-018387-ci5wx26t	17	5	our	-PRON-	PRP$
cord-018387-ci5wx26t	17	6	current	current	JJ
cord-018387-ci5wx26t	17	7	understanding	understanding	NN
cord-018387-ci5wx26t	17	8	of	of	IN
cord-018387-ci5wx26t	17	9	the	the	DT
cord-018387-ci5wx26t	17	10	modulatory	modulatory	JJ
cord-018387-ci5wx26t	17	11	potential	potential	NN
cord-018387-ci5wx26t	17	12	of	of	IN
cord-018387-ci5wx26t	17	13	nutrition	nutrition	NN
cord-018387-ci5wx26t	17	14	that	that	WDT
cord-018387-ci5wx26t	17	15	may	may	MD
cord-018387-ci5wx26t	17	16	mediate	mediate	VB
cord-018387-ci5wx26t	17	17	anti	anti	JJ
cord-018387-ci5wx26t	17	18	-	-	JJ
cord-018387-ci5wx26t	17	19	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	17	20	effects	effect	NNS
cord-018387-ci5wx26t	17	21	and	and	CC
cord-018387-ci5wx26t	17	22	thus	thus	RB
cord-018387-ci5wx26t	17	23	positively	positively	RB
cord-018387-ci5wx26t	17	24	affect	affect	VBP
cord-018387-ci5wx26t	17	25	immunity	immunity	NN
cord-018387-ci5wx26t	17	26	and	and	CC
cord-018387-ci5wx26t	17	27	the	the	DT
cord-018387-ci5wx26t	17	28	aging	age	VBG
cord-018387-ci5wx26t	17	29	brain	brain	NN
cord-018387-ci5wx26t	17	30	.	.	.
cord-018387-ci5wx26t	18	1	It	-PRON-	PRP
cord-018387-ci5wx26t	18	2	is	be	VBZ
cord-018387-ci5wx26t	18	3	now	now	RB
cord-018387-ci5wx26t	18	4	clear	clear	JJ
cord-018387-ci5wx26t	18	5	that	that	IN
cord-018387-ci5wx26t	18	6	a	a	DT
cord-018387-ci5wx26t	18	7	variety	variety	NN
cord-018387-ci5wx26t	18	8	of	of	IN
cord-018387-ci5wx26t	18	9	genetic	genetic	JJ
cord-018387-ci5wx26t	18	10	and	and	CC
cord-018387-ci5wx26t	18	11	environmental	environmental	JJ
cord-018387-ci5wx26t	18	12	factors	factor	NNS
cord-018387-ci5wx26t	18	13	impact	impact	VBP
cord-018387-ci5wx26t	18	14	upon	upon	IN
cord-018387-ci5wx26t	18	15	health	health	NN
cord-018387-ci5wx26t	18	16	in	in	IN
cord-018387-ci5wx26t	18	17	old	old	JJ
cord-018387-ci5wx26t	18	18	age	age	NN
cord-018387-ci5wx26t	18	19	,	,	,
cord-018387-ci5wx26t	18	20	including	include	VBG
cord-018387-ci5wx26t	18	21	effects	effect	NNS
cord-018387-ci5wx26t	18	22	on	on	IN
cord-018387-ci5wx26t	18	23	immunity	immunity	NN
cord-018387-ci5wx26t	18	24	.	.	.
cord-018387-ci5wx26t	19	1	However	however	RB
cord-018387-ci5wx26t	19	2	,	,	,
cord-018387-ci5wx26t	19	3	the	the	DT
cord-018387-ci5wx26t	19	4	relative	relative	JJ
cord-018387-ci5wx26t	19	5	contribution	contribution	NN
cord-018387-ci5wx26t	19	6	of	of	IN
cord-018387-ci5wx26t	19	7	these	these	DT
cord-018387-ci5wx26t	19	8	factors	factor	NNS
cord-018387-ci5wx26t	19	9	to	to	IN
cord-018387-ci5wx26t	19	10	immunosenescence	immunosenescence	NNP
cord-018387-ci5wx26t	19	11	will	will	MD
cord-018387-ci5wx26t	19	12	have	have	VB
cord-018387-ci5wx26t	19	13	to	to	TO
cord-018387-ci5wx26t	19	14	be	be	VB
cord-018387-ci5wx26t	19	15	more	more	RBR
cord-018387-ci5wx26t	19	16	accurately	accurately	RB
cord-018387-ci5wx26t	19	17	established	establish	VBN
cord-018387-ci5wx26t	19	18	.	.	.
cord-018387-ci5wx26t	20	1	These	these	DT
cord-018387-ci5wx26t	20	2	variables	variable	NNS
cord-018387-ci5wx26t	20	3	clearly	clearly	RB
cord-018387-ci5wx26t	20	4	include	include	VBP
cord-018387-ci5wx26t	20	5	nutrition	nutrition	NN
cord-018387-ci5wx26t	20	6	(	(	-LRB-
cord-018387-ci5wx26t	20	7	micro	micro	JJ
cord-018387-ci5wx26t	20	8	and	and	CC
cord-018387-ci5wx26t	20	9	macro	macro	NNP
cord-018387-ci5wx26t	20	10	)	)	-RRB-
cord-018387-ci5wx26t	20	11	,	,	,
cord-018387-ci5wx26t	20	12	physical	physical	JJ
cord-018387-ci5wx26t	20	13	activity	activity	NN
cord-018387-ci5wx26t	20	14	,	,	,
cord-018387-ci5wx26t	20	15	mental	mental	JJ
cord-018387-ci5wx26t	20	16	well	well	RB
cord-018387-ci5wx26t	20	17	-	-	HYPH
cord-018387-ci5wx26t	20	18	being	being	NN
cord-018387-ci5wx26t	20	19	,	,	,
cord-018387-ci5wx26t	20	20	as	as	RB
cord-018387-ci5wx26t	20	21	well	well	RB
cord-018387-ci5wx26t	20	22	as	as	IN
cord-018387-ci5wx26t	20	23	gender	gender	NN
cord-018387-ci5wx26t	20	24	and	and	CC
cord-018387-ci5wx26t	20	25	ethnicity	ethnicity	NN
cord-018387-ci5wx26t	20	26	,	,	,
cord-018387-ci5wx26t	20	27	genetic	genetic	JJ
cord-018387-ci5wx26t	20	28	background	background	NN
cord-018387-ci5wx26t	20	29	,	,	,
cord-018387-ci5wx26t	20	30	psychosocial	psychosocial	JJ
cord-018387-ci5wx26t	20	31	parameters	parameter	NNS
cord-018387-ci5wx26t	20	32	(	(	-LRB-
cord-018387-ci5wx26t	20	33	including	include	VBG
cord-018387-ci5wx26t	20	34	stress	stress	NN
cord-018387-ci5wx26t	20	35	)	)	-RRB-
cord-018387-ci5wx26t	20	36	,	,	,
cord-018387-ci5wx26t	20	37	socioeconomic	socioeconomic	JJ
cord-018387-ci5wx26t	20	38	status	status	NN
cord-018387-ci5wx26t	20	39	,	,	,
cord-018387-ci5wx26t	20	40	earlylife	earlylife	NN
cord-018387-ci5wx26t	20	41	events	event	NNS
cord-018387-ci5wx26t	20	42	,	,	,
cord-018387-ci5wx26t	20	43	and	and	CC
cord-018387-ci5wx26t	20	44	different	different	JJ
cord-018387-ci5wx26t	20	45	chronic	chronic	JJ
cord-018387-ci5wx26t	20	46	infections	infection	NNS
cord-018387-ci5wx26t	20	47	[	[	-LRB-
cord-018387-ci5wx26t	20	48	1	1	CD
cord-018387-ci5wx26t	20	49	,	,	,
cord-018387-ci5wx26t	20	50	2	2	CD
cord-018387-ci5wx26t	20	51	]	]	-RRB-
cord-018387-ci5wx26t	20	52	.	.	.
cord-018387-ci5wx26t	21	1	contributing	contribute	VBG
cord-018387-ci5wx26t	21	2	to	to	IN
cord-018387-ci5wx26t	21	3	immune	immune	JJ
cord-018387-ci5wx26t	21	4	competence	competence	NN
cord-018387-ci5wx26t	21	5	,	,	,
cord-018387-ci5wx26t	21	6	since	since	IN
cord-018387-ci5wx26t	21	7	undernutrition	undernutrition	NN
cord-018387-ci5wx26t	21	8	impairs	impair	VBZ
cord-018387-ci5wx26t	21	9	the	the	DT
cord-018387-ci5wx26t	21	10	immune	immune	JJ
cord-018387-ci5wx26t	21	11	system	system	NN
cord-018387-ci5wx26t	21	12	,	,	,
cord-018387-ci5wx26t	21	13	suppressing	suppress	VBG
cord-018387-ci5wx26t	21	14	immune	immune	JJ
cord-018387-ci5wx26t	21	15	functions	function	NNS
cord-018387-ci5wx26t	21	16	that	that	WDT
cord-018387-ci5wx26t	21	17	are	be	VBP
cord-018387-ci5wx26t	21	18	fundamental	fundamental	JJ
cord-018387-ci5wx26t	21	19	to	to	TO
cord-018387-ci5wx26t	21	20	host	host	VB
cord-018387-ci5wx26t	21	21	protection	protection	NN
cord-018387-ci5wx26t	21	22	.	.	.
cord-018387-ci5wx26t	22	1	Undernutrition	Undernutrition	NNP
cord-018387-ci5wx26t	22	2	leading	lead	VBG
cord-018387-ci5wx26t	22	3	to	to	IN
cord-018387-ci5wx26t	22	4	an	an	DT
cord-018387-ci5wx26t	22	5	impairment	impairment	NN
cord-018387-ci5wx26t	22	6	of	of	IN
cord-018387-ci5wx26t	22	7	immune	immune	JJ
cord-018387-ci5wx26t	22	8	function	function	NN
cord-018387-ci5wx26t	22	9	can	can	MD
cord-018387-ci5wx26t	22	10	be	be	VB
cord-018387-ci5wx26t	22	11	due	due	JJ
cord-018387-ci5wx26t	22	12	either	either	RB
cord-018387-ci5wx26t	22	13	to	to	TO
cord-018387-ci5wx26t	22	14	insufficient	insufficient	JJ
cord-018387-ci5wx26t	22	15	intake	intake	NN
cord-018387-ci5wx26t	22	16	of	of	IN
cord-018387-ci5wx26t	22	17	energy	energy	NN
cord-018387-ci5wx26t	22	18	and	and	CC
cord-018387-ci5wx26t	22	19	macronutrients	macronutrient	NNS
cord-018387-ci5wx26t	22	20	or	or	CC
cord-018387-ci5wx26t	22	21	to	to	IN
cord-018387-ci5wx26t	22	22	specific	specific	JJ
cord-018387-ci5wx26t	22	23	deficiencies	deficiency	NNS
cord-018387-ci5wx26t	22	24	in	in	IN
cord-018387-ci5wx26t	22	25	some	some	DT
cord-018387-ci5wx26t	22	26	particular	particular	JJ
cord-018387-ci5wx26t	22	27	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	22	28	,	,	,
cord-018387-ci5wx26t	22	29	although	although	IN
cord-018387-ci5wx26t	22	30	often	often	RB
cord-018387-ci5wx26t	22	31	these	these	DT
cord-018387-ci5wx26t	22	32	occur	occur	VBP
cord-018387-ci5wx26t	22	33	in	in	IN
cord-018387-ci5wx26t	22	34	combination	combination	NN
cord-018387-ci5wx26t	22	35	[	[	-LRB-
cord-018387-ci5wx26t	22	36	4	4	CD
cord-018387-ci5wx26t	22	37	]	]	-RRB-
cord-018387-ci5wx26t	22	38	.	.	.
cord-018387-ci5wx26t	23	1	Among	among	IN
cord-018387-ci5wx26t	23	2	other	other	JJ
cord-018387-ci5wx26t	23	3	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	23	4	,	,	,
cord-018387-ci5wx26t	23	5	zinc	zinc	NN
cord-018387-ci5wx26t	23	6	,	,	,
cord-018387-ci5wx26t	23	7	for	for	IN
cord-018387-ci5wx26t	23	8	instance	instance	NN
cord-018387-ci5wx26t	23	9	,	,	,
cord-018387-ci5wx26t	23	10	has	have	VBZ
cord-018387-ci5wx26t	23	11	an	an	DT
cord-018387-ci5wx26t	23	12	essential	essential	JJ
cord-018387-ci5wx26t	23	13	significance	significance	NN
cord-018387-ci5wx26t	23	14	to	to	IN
cord-018387-ci5wx26t	23	15	health	health	NN
cord-018387-ci5wx26t	23	16	;	;	:
cord-018387-ci5wx26t	23	17	its	-PRON-	PRP$
cord-018387-ci5wx26t	23	18	deficiency	deficiency	NN
cord-018387-ci5wx26t	23	19	is	be	VBZ
cord-018387-ci5wx26t	23	20	responsible	responsible	JJ
cord-018387-ci5wx26t	23	21	for	for	IN
cord-018387-ci5wx26t	23	22	various	various	JJ
cord-018387-ci5wx26t	23	23	diseases	disease	NNS
cord-018387-ci5wx26t	23	24	.	.	.
cord-018387-ci5wx26t	24	1	Zinc	zinc	NN
cord-018387-ci5wx26t	24	2	is	be	VBZ
cord-018387-ci5wx26t	24	3	one	one	CD
cord-018387-ci5wx26t	24	4	of	of	IN
cord-018387-ci5wx26t	24	5	the	the	DT
cord-018387-ci5wx26t	24	6	most	most	RBS
cord-018387-ci5wx26t	24	7	important	important	JJ
cord-018387-ci5wx26t	24	8	trace	trace	NN
cord-018387-ci5wx26t	24	9	elements	element	NNS
cord-018387-ci5wx26t	24	10	in	in	IN
cord-018387-ci5wx26t	24	11	the	the	DT
cord-018387-ci5wx26t	24	12	organism	organism	NN
cord-018387-ci5wx26t	24	13	,	,	,
cord-018387-ci5wx26t	24	14	with	with	IN
cord-018387-ci5wx26t	24	15	three	three	CD
cord-018387-ci5wx26t	24	16	major	major	JJ
cord-018387-ci5wx26t	24	17	biological	biological	JJ
cord-018387-ci5wx26t	24	18	roles	role	NNS
cord-018387-ci5wx26t	24	19	,	,	,
cord-018387-ci5wx26t	24	20	as	as	IN
cord-018387-ci5wx26t	24	21	a	a	DT
cord-018387-ci5wx26t	24	22	catalyst	catalyst	NN
cord-018387-ci5wx26t	24	23	,	,	,
cord-018387-ci5wx26t	24	24	structural	structural	JJ
cord-018387-ci5wx26t	24	25	,	,	,
cord-018387-ci5wx26t	24	26	and	and	CC
cord-018387-ci5wx26t	24	27	regulatory	regulatory	JJ
cord-018387-ci5wx26t	24	28	ion	ion	NN
cord-018387-ci5wx26t	24	29	.	.	.
cord-018387-ci5wx26t	25	1	It	-PRON-	PRP
cord-018387-ci5wx26t	25	2	plays	play	VBZ
cord-018387-ci5wx26t	25	3	a	a	DT
cord-018387-ci5wx26t	25	4	critical	critical	JJ
cord-018387-ci5wx26t	25	5	role	role	NN
cord-018387-ci5wx26t	25	6	in	in	IN
cord-018387-ci5wx26t	25	7	organism	organism	NN
cord-018387-ci5wx26t	25	8	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	25	9	,	,	,
cord-018387-ci5wx26t	25	10	in	in	IN
cord-018387-ci5wx26t	25	11	immune	immune	JJ
cord-018387-ci5wx26t	25	12	function	function	NN
cord-018387-ci5wx26t	25	13	,	,	,
cord-018387-ci5wx26t	25	14	in	in	IN
cord-018387-ci5wx26t	25	15	oxidative	oxidative	JJ
cord-018387-ci5wx26t	25	16	stress	stress	NN
cord-018387-ci5wx26t	25	17	,	,	,
cord-018387-ci5wx26t	25	18	in	in	IN
cord-018387-ci5wx26t	25	19	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	25	20	,	,	,
cord-018387-ci5wx26t	25	21	and	and	CC
cord-018387-ci5wx26t	25	22	in	in	IN
cord-018387-ci5wx26t	25	23	other	other	JJ
cord-018387-ci5wx26t	25	24	physiological	physiological	JJ
cord-018387-ci5wx26t	25	25	activities	activity	NNS
cord-018387-ci5wx26t	25	26	[	[	-LRB-
cord-018387-ci5wx26t	25	27	2	2	CD
cord-018387-ci5wx26t	25	28	,	,	,
cord-018387-ci5wx26t	25	29	5	5	CD
cord-018387-ci5wx26t	25	30	]	]	-RRB-
cord-018387-ci5wx26t	25	31	.	.	.
cord-018387-ci5wx26t	26	1	Thus	thus	RB
cord-018387-ci5wx26t	26	2	,	,	,
cord-018387-ci5wx26t	26	3	zinc	zinc	NN
cord-018387-ci5wx26t	26	4	deficiency	deficiency	NN
cord-018387-ci5wx26t	26	5	may	may	MD
cord-018387-ci5wx26t	26	6	adversely	adversely	RB
cord-018387-ci5wx26t	26	7	affect	affect	VB
cord-018387-ci5wx26t	26	8	the	the	DT
cord-018387-ci5wx26t	26	9	immunological	immunological	JJ
cord-018387-ci5wx26t	26	10	status	status	NN
cord-018387-ci5wx26t	26	11	,	,	,
cord-018387-ci5wx26t	26	12	increase	increase	VB
cord-018387-ci5wx26t	26	13	oxidative	oxidative	JJ
cord-018387-ci5wx26t	26	14	stress	stress	NN
cord-018387-ci5wx26t	26	15	,	,	,
cord-018387-ci5wx26t	26	16	lead	lead	VB
cord-018387-ci5wx26t	26	17	to	to	IN
cord-018387-ci5wx26t	26	18	the	the	DT
cord-018387-ci5wx26t	26	19	generation	generation	NN
cord-018387-ci5wx26t	26	20	of	of	IN
cord-018387-ci5wx26t	26	21	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	26	22	cytokines	cytokine	NNS
cord-018387-ci5wx26t	26	23	,	,	,
cord-018387-ci5wx26t	26	24	and	and	CC
cord-018387-ci5wx26t	26	25	influence	influence	VB
cord-018387-ci5wx26t	26	26	the	the	DT
cord-018387-ci5wx26t	26	27	progression	progression	NN
cord-018387-ci5wx26t	26	28	of	of	IN
cord-018387-ci5wx26t	26	29	many	many	JJ
cord-018387-ci5wx26t	26	30	chronic	chronic	JJ
cord-018387-ci5wx26t	26	31	diseases	disease	NNS
cord-018387-ci5wx26t	26	32	,	,	,
cord-018387-ci5wx26t	26	33	including	include	VBG
cord-018387-ci5wx26t	26	34	atherosclerosis	atherosclerosis	NN
cord-018387-ci5wx26t	26	35	,	,	,
cord-018387-ci5wx26t	26	36	neurological	neurological	JJ
cord-018387-ci5wx26t	26	37	disorders	disorder	NNS
cord-018387-ci5wx26t	26	38	,	,	,
cord-018387-ci5wx26t	26	39	autoimmune	autoimmune	JJ
cord-018387-ci5wx26t	26	40	diseases	disease	NNS
cord-018387-ci5wx26t	26	41	,	,	,
cord-018387-ci5wx26t	26	42	age	age	NN
cord-018387-ci5wx26t	26	43	-	-	HYPH
cord-018387-ci5wx26t	26	44	related	relate	VBN
cord-018387-ci5wx26t	26	45	degenerative	degenerative	JJ
cord-018387-ci5wx26t	26	46	diseases	disease	NNS
cord-018387-ci5wx26t	26	47	,	,	,
cord-018387-ci5wx26t	26	48	and	and	CC
cord-018387-ci5wx26t	26	49	various	various	JJ
cord-018387-ci5wx26t	26	50	malignancies	malignancy	NNS
cord-018387-ci5wx26t	26	51	[	[	-LRB-
cord-018387-ci5wx26t	26	52	5	5	CD
cord-018387-ci5wx26t	26	53	]	]	-RRB-
cord-018387-ci5wx26t	26	54	.	.	.
cord-018387-ci5wx26t	27	1	Zinc	zinc	NN
cord-018387-ci5wx26t	27	2	deficiency	deficiency	NN
cord-018387-ci5wx26t	27	3	is	be	VBZ
cord-018387-ci5wx26t	27	4	known	know	VBN
cord-018387-ci5wx26t	27	5	to	to	TO
cord-018387-ci5wx26t	27	6	decrease	decrease	VB
cord-018387-ci5wx26t	27	7	innate	innate	JJ
cord-018387-ci5wx26t	27	8	immune	immune	JJ
cord-018387-ci5wx26t	27	9	function	function	NN
cord-018387-ci5wx26t	27	10	.	.	.
cord-018387-ci5wx26t	28	1	It	-PRON-	PRP
cord-018387-ci5wx26t	28	2	particularly	particularly	RB
cord-018387-ci5wx26t	28	3	impairs	impair	VBZ
cord-018387-ci5wx26t	28	4	the	the	DT
cord-018387-ci5wx26t	28	5	lytic	lytic	JJ
cord-018387-ci5wx26t	28	6	activity	activity	NN
cord-018387-ci5wx26t	28	7	of	of	IN
cord-018387-ci5wx26t	28	8	natural	natural	JJ
cord-018387-ci5wx26t	28	9	killer	killer	NN
cord-018387-ci5wx26t	28	10	(	(	-LRB-
cord-018387-ci5wx26t	28	11	NK	NK	NNP
cord-018387-ci5wx26t	28	12	)	)	-RRB-
cord-018387-ci5wx26t	28	13	cells	cell	NNS
cord-018387-ci5wx26t	28	14	,	,	,
cord-018387-ci5wx26t	28	15	reduces	reduce	VBZ
cord-018387-ci5wx26t	28	16	natural	natural	JJ
cord-018387-ci5wx26t	28	17	killer	killer	NN
cord-018387-ci5wx26t	28	18	T	t	NN
cord-018387-ci5wx26t	28	19	(	(	-LRB-
cord-018387-ci5wx26t	28	20	NKT)-cell	nkt)-cell	CD
cord-018387-ci5wx26t	28	21	cytotoxicity	cytotoxicity	NN
cord-018387-ci5wx26t	28	22	and	and	CC
cord-018387-ci5wx26t	28	23	immune	immune	JJ
cord-018387-ci5wx26t	28	24	signaling	signaling	NN
cord-018387-ci5wx26t	28	25	,	,	,
cord-018387-ci5wx26t	28	26	influences	influence	VBZ
cord-018387-ci5wx26t	28	27	the	the	DT
cord-018387-ci5wx26t	28	28	neuroendocrine	neuroendocrine	JJ
cord-018387-ci5wx26t	28	29	-	-	HYPH
cord-018387-ci5wx26t	28	30	immune	immune	JJ
cord-018387-ci5wx26t	28	31	pathway	pathway	NN
cord-018387-ci5wx26t	28	32	,	,	,
cord-018387-ci5wx26t	28	33	and	and	CC
cord-018387-ci5wx26t	28	34	alters	alter	VBZ
cord-018387-ci5wx26t	28	35	cytokine	cytokine	JJ
cord-018387-ci5wx26t	28	36	generation	generation	NN
cord-018387-ci5wx26t	28	37	in	in	IN
cord-018387-ci5wx26t	28	38	mast	mast	NN
cord-018387-ci5wx26t	28	39	cells	cell	NNS
cord-018387-ci5wx26t	28	40	[	[	-LRB-
cord-018387-ci5wx26t	28	41	6	6	CD
cord-018387-ci5wx26t	28	42	,	,	,
cord-018387-ci5wx26t	28	43	7	7	CD
cord-018387-ci5wx26t	28	44	]	]	-RRB-
cord-018387-ci5wx26t	28	45	.	.	.
cord-018387-ci5wx26t	29	1	However	however	RB
cord-018387-ci5wx26t	29	2	,	,	,
cord-018387-ci5wx26t	29	3	excessive	excessive	JJ
cord-018387-ci5wx26t	29	4	amounts	amount	NNS
cord-018387-ci5wx26t	29	5	of	of	IN
cord-018387-ci5wx26t	29	6	some	some	DT
cord-018387-ci5wx26t	29	7	nutrients	nutrient	NNS
cord-018387-ci5wx26t	29	8	may	may	MD
cord-018387-ci5wx26t	29	9	also	also	RB
cord-018387-ci5wx26t	29	10	impair	impair	VB
cord-018387-ci5wx26t	29	11	immune	immune	JJ
cord-018387-ci5wx26t	29	12	function	function	NN
cord-018387-ci5wx26t	29	13	.	.	.
cord-018387-ci5wx26t	30	1	Overnutrition	Overnutrition	NNP
cord-018387-ci5wx26t	30	2	,	,	,
cord-018387-ci5wx26t	30	3	combined	combine	VBN
cord-018387-ci5wx26t	30	4	with	with	IN
cord-018387-ci5wx26t	30	5	an	an	DT
cord-018387-ci5wx26t	30	6	inactive	inactive	JJ
cord-018387-ci5wx26t	30	7	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	30	8	and	and	CC
cord-018387-ci5wx26t	30	9	sedentary	sedentary	JJ
cord-018387-ci5wx26t	30	10	behavior	behavior	NN
cord-018387-ci5wx26t	30	11	,	,	,
cord-018387-ci5wx26t	30	12	promotes	promote	VBZ
cord-018387-ci5wx26t	30	13	the	the	DT
cord-018387-ci5wx26t	30	14	accumulation	accumulation	NN
cord-018387-ci5wx26t	30	15	of	of	IN
cord-018387-ci5wx26t	30	16	visceral	visceral	JJ
cord-018387-ci5wx26t	30	17	fat	fat	NN
cord-018387-ci5wx26t	30	18	and	and	CC
cord-018387-ci5wx26t	30	19	leads	lead	VBZ
cord-018387-ci5wx26t	30	20	to	to	IN
cord-018387-ci5wx26t	30	21	obesity	obesity	NN
cord-018387-ci5wx26t	30	22	.	.	.
cord-018387-ci5wx26t	31	1	Accumulating	accumulate	VBG
cord-018387-ci5wx26t	31	2	evidence	evidence	NN
cord-018387-ci5wx26t	31	3	indicates	indicate	VBZ
cord-018387-ci5wx26t	31	4	that	that	IN
cord-018387-ci5wx26t	31	5	obesity	obesity	NN
cord-018387-ci5wx26t	31	6	causes	cause	VBZ
cord-018387-ci5wx26t	31	7	chronic	chronic	JJ
cord-018387-ci5wx26t	31	8	low	low	JJ
cord-018387-ci5wx26t	31	9	-	-	HYPH
cord-018387-ci5wx26t	31	10	grade	grade	NN
cord-018387-ci5wx26t	31	11	inflammation	inflammation	NN
cord-018387-ci5wx26t	31	12	and	and	CC
cord-018387-ci5wx26t	31	13	the	the	DT
cord-018387-ci5wx26t	31	14	development	development	NN
cord-018387-ci5wx26t	31	15	of	of	IN
cord-018387-ci5wx26t	31	16	systemic	systemic	JJ
cord-018387-ci5wx26t	31	17	metabolic	metabolic	JJ
cord-018387-ci5wx26t	31	18	dysfunction	dysfunction	NN
cord-018387-ci5wx26t	31	19	that	that	WDT
cord-018387-ci5wx26t	31	20	appears	appear	VBZ
cord-018387-ci5wx26t	31	21	to	to	TO
cord-018387-ci5wx26t	31	22	be	be	VB
cord-018387-ci5wx26t	31	23	aetiologically	aetiologically	RB
cord-018387-ci5wx26t	31	24	associated	associate	VBN
cord-018387-ci5wx26t	31	25	with	with	IN
cord-018387-ci5wx26t	31	26	obesity	obesity	NN
cord-018387-ci5wx26t	31	27	-	-	HYPH
cord-018387-ci5wx26t	31	28	linked	link	VBN
cord-018387-ci5wx26t	31	29	disorders	disorder	NNS
cord-018387-ci5wx26t	31	30	[	[	-LRB-
cord-018387-ci5wx26t	31	31	2	2	CD
cord-018387-ci5wx26t	31	32	,	,	,
cord-018387-ci5wx26t	31	33	8	8	CD
cord-018387-ci5wx26t	31	34	]	]	-RRB-
cord-018387-ci5wx26t	31	35	.	.	.
cord-018387-ci5wx26t	32	1	Adipose	adipose	JJ
cord-018387-ci5wx26t	32	2	tissue	tissue	NN
cord-018387-ci5wx26t	32	3	acts	act	VBZ
cord-018387-ci5wx26t	32	4	as	as	IN
cord-018387-ci5wx26t	32	5	a	a	DT
cord-018387-ci5wx26t	32	6	key	key	JJ
cord-018387-ci5wx26t	32	7	endocrine	endocrine	JJ
cord-018387-ci5wx26t	32	8	organ	organ	NN
cord-018387-ci5wx26t	32	9	by	by	IN
cord-018387-ci5wx26t	32	10	releasing	release	VBG
cord-018387-ci5wx26t	32	11	bioactive	bioactive	JJ
cord-018387-ci5wx26t	32	12	substances	substance	NNS
cord-018387-ci5wx26t	32	13	,	,	,
cord-018387-ci5wx26t	32	14	known	know	VBN
cord-018387-ci5wx26t	32	15	as	as	IN
cord-018387-ci5wx26t	32	16	adipokines	adipokine	NNS
cord-018387-ci5wx26t	32	17	,	,	,
cord-018387-ci5wx26t	32	18	that	that	WDT
cord-018387-ci5wx26t	32	19	may	may	MD
cord-018387-ci5wx26t	32	20	have	have	VB
cord-018387-ci5wx26t	32	21	either	either	CC
cord-018387-ci5wx26t	32	22	pro	pro	JJ
cord-018387-ci5wx26t	32	23	-	-	JJ
cord-018387-ci5wx26t	32	24	or	or	CC
cord-018387-ci5wx26t	32	25	anti	anti	JJ
cord-018387-ci5wx26t	32	26	-	-	JJ
cord-018387-ci5wx26t	32	27	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	32	28	activities	activity	NNS
cord-018387-ci5wx26t	32	29	[	[	-LRB-
cord-018387-ci5wx26t	32	30	9	9	CD
cord-018387-ci5wx26t	32	31	]	]	-RRB-
cord-018387-ci5wx26t	32	32	.	.	.
cord-018387-ci5wx26t	33	1	The	the	DT
cord-018387-ci5wx26t	33	2	production	production	NN
cord-018387-ci5wx26t	33	3	of	of	IN
cord-018387-ci5wx26t	33	4	pro	pro	JJ
cord-018387-ci5wx26t	33	5	-	-	JJ
cord-018387-ci5wx26t	33	6	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	33	7	adipokines	adipokine	NNS
cord-018387-ci5wx26t	33	8	,	,	,
cord-018387-ci5wx26t	33	9	such	such	JJ
cord-018387-ci5wx26t	33	10	as	as	IN
cord-018387-ci5wx26t	33	11	tumor	tumor	NN
cord-018387-ci5wx26t	33	12	necrosis	necrosis	NN
cord-018387-ci5wx26t	33	13	factor	factor	NN
cord-018387-ci5wx26t	33	14	(	(	-LRB-
cord-018387-ci5wx26t	33	15	TNF	TNF	NNP
cord-018387-ci5wx26t	33	16	)	)	-RRB-
cord-018387-ci5wx26t	33	17	,	,	,
cord-018387-ci5wx26t	33	18	leptin	leptin	NN
cord-018387-ci5wx26t	33	19	,	,	,
cord-018387-ci5wx26t	33	20	retinol	retinol	NN
cord-018387-ci5wx26t	33	21	-	-	HYPH
cord-018387-ci5wx26t	33	22	binding	bind	VBG
cord-018387-ci5wx26t	33	23	protein	protein	NN
cord-018387-ci5wx26t	33	24	4	4	CD
cord-018387-ci5wx26t	33	25	,	,	,
cord-018387-ci5wx26t	34	1	lipocalin	lipocalin	NNP
cord-018387-ci5wx26t	34	2	2	2	CD
cord-018387-ci5wx26t	34	3	,	,	,
cord-018387-ci5wx26t	34	4	IL-6	IL-6	NNP
cord-018387-ci5wx26t	34	5	,	,	,
cord-018387-ci5wx26t	34	6	IL-18	IL-18	NNP
cord-018387-ci5wx26t	34	7	,	,	,
cord-018387-ci5wx26t	34	8	and	and	CC
cord-018387-ci5wx26t	34	9	angiopoietin	angiopoietin	NN
cord-018387-ci5wx26t	34	10	-	-	HYPH
cord-018387-ci5wx26t	34	11	like	like	JJ
cord-018387-ci5wx26t	34	12	protein	protein	NN
cord-018387-ci5wx26t	34	13	2	2	CD
cord-018387-ci5wx26t	34	14	,	,	,
cord-018387-ci5wx26t	34	15	in	in	IN
cord-018387-ci5wx26t	34	16	expanding	expand	VBG
cord-018387-ci5wx26t	34	17	fat	fat	JJ
cord-018387-ci5wx26t	34	18	tissue	tissue	NN
cord-018387-ci5wx26t	34	19	increases	increase	NNS
cord-018387-ci5wx26t	34	20	,	,	,
cord-018387-ci5wx26t	34	21	while	while	IN
cord-018387-ci5wx26t	34	22	the	the	DT
cord-018387-ci5wx26t	34	23	concentrations	concentration	NNS
cord-018387-ci5wx26t	34	24	of	of	IN
cord-018387-ci5wx26t	34	25	anti	anti	JJ
cord-018387-ci5wx26t	34	26	-	-	JJ
cord-018387-ci5wx26t	34	27	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	34	28	cytokines	cytokine	NNS
cord-018387-ci5wx26t	34	29	are	be	VBP
cord-018387-ci5wx26t	34	30	reduced	reduce	VBN
cord-018387-ci5wx26t	34	31	[	[	-LRB-
cord-018387-ci5wx26t	34	32	9	9	CD
cord-018387-ci5wx26t	34	33	]	]	-RRB-
cord-018387-ci5wx26t	34	34	.	.	.
cord-018387-ci5wx26t	35	1	This	this	DT
cord-018387-ci5wx26t	35	2	process	process	NN
cord-018387-ci5wx26t	35	3	is	be	VBZ
cord-018387-ci5wx26t	35	4	accompanied	accompany	VBN
cord-018387-ci5wx26t	35	5	by	by	IN
cord-018387-ci5wx26t	35	6	an	an	DT
cord-018387-ci5wx26t	35	7	infiltration	infiltration	NN
cord-018387-ci5wx26t	35	8	of	of	IN
cord-018387-ci5wx26t	35	9	adipose	adipose	JJ
cord-018387-ci5wx26t	35	10	tissue	tissue	NN
cord-018387-ci5wx26t	35	11	with	with	IN
cord-018387-ci5wx26t	35	12	pro	pro	JJ
cord-018387-ci5wx26t	35	13	-	-	JJ
cord-018387-ci5wx26t	35	14	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	35	15	mediators	mediator	NNS
cord-018387-ci5wx26t	35	16	and	and	CC
cord-018387-ci5wx26t	35	17	the	the	DT
cord-018387-ci5wx26t	35	18	induction	induction	NN
cord-018387-ci5wx26t	35	19	of	of	IN
cord-018387-ci5wx26t	35	20	a	a	DT
cord-018387-ci5wx26t	35	21	low	low	JJ
cord-018387-ci5wx26t	35	22	-	-	HYPH
cord-018387-ci5wx26t	35	23	grade	grade	NN
cord-018387-ci5wx26t	35	24	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	35	25	state	state	NN
cord-018387-ci5wx26t	35	26	,	,	,
cord-018387-ci5wx26t	35	27	which	which	WDT
cord-018387-ci5wx26t	35	28	is	be	VBZ
cord-018387-ci5wx26t	35	29	characterized	characterize	VBN
cord-018387-ci5wx26t	35	30	by	by	IN
cord-018387-ci5wx26t	35	31	elevated	elevated	JJ
cord-018387-ci5wx26t	35	32	levels	level	NNS
cord-018387-ci5wx26t	35	33	of	of	IN
cord-018387-ci5wx26t	35	34	circulating	circulate	VBG
cord-018387-ci5wx26t	35	35	inflammation	inflammation	NN
cord-018387-ci5wx26t	35	36	markers	marker	NNS
cord-018387-ci5wx26t	35	37	,	,	,
cord-018387-ci5wx26t	35	38	such	such	JJ
cord-018387-ci5wx26t	35	39	as	as	IN
cord-018387-ci5wx26t	35	40	IL-6	IL-6	NNP
cord-018387-ci5wx26t	35	41	,	,	,
cord-018387-ci5wx26t	35	42	TNF	TNF	NNP
cord-018387-ci5wx26t	35	43	,	,	,
cord-018387-ci5wx26t	35	44	and	and	CC
cord-018387-ci5wx26t	35	45	C	c	NN
cord-018387-ci5wx26t	35	46	-	-	HYPH
cord-018387-ci5wx26t	35	47	reactive	reactive	JJ
cord-018387-ci5wx26t	35	48	protein	protein	NN
cord-018387-ci5wx26t	35	49	(	(	-LRB-
cord-018387-ci5wx26t	35	50	CRP	CRP	NNP
cord-018387-ci5wx26t	35	51	)	)	-RRB-
cord-018387-ci5wx26t	35	52	.	.	.
cord-018387-ci5wx26t	36	1	Adipose	adipose	JJ
cord-018387-ci5wx26t	36	2	tissue	tissue	NN
cord-018387-ci5wx26t	36	3	is	be	VBZ
cord-018387-ci5wx26t	36	4	infiltrated	infiltrate	VBN
cord-018387-ci5wx26t	36	5	with	with	IN
cord-018387-ci5wx26t	36	6	macrophages	macrophage	NNS
cord-018387-ci5wx26t	36	7	in	in	IN
cord-018387-ci5wx26t	36	8	two	two	CD
cord-018387-ci5wx26t	36	9	separate	separate	JJ
cord-018387-ci5wx26t	36	10	polarization	polarization	NN
cord-018387-ci5wx26t	36	11	states	state	NNS
cord-018387-ci5wx26t	36	12	:	:	:
cord-018387-ci5wx26t	36	13	M1	M1	NNP
cord-018387-ci5wx26t	36	14	,	,	,
cord-018387-ci5wx26t	36	15	which	which	WDT
cord-018387-ci5wx26t	36	16	produces	produce	VBZ
cord-018387-ci5wx26t	36	17	pro	pro	JJ
cord-018387-ci5wx26t	36	18	-	-	JJ
cord-018387-ci5wx26t	36	19	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	36	20	cytokines	cytokine	NNS
cord-018387-ci5wx26t	36	21	,	,	,
cord-018387-ci5wx26t	36	22	and	and	CC
cord-018387-ci5wx26t	36	23	M2	M2	NNP
cord-018387-ci5wx26t	36	24	,	,	,
cord-018387-ci5wx26t	36	25	which	which	WDT
cord-018387-ci5wx26t	36	26	produces	produce	VBZ
cord-018387-ci5wx26t	36	27	anti	anti	JJ
cord-018387-ci5wx26t	36	28	-	-	JJ
cord-018387-ci5wx26t	36	29	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	36	30	cytokines	cytokine	NNS
cord-018387-ci5wx26t	36	31	.	.	.
cord-018387-ci5wx26t	37	1	Therefore	therefore	RB
cord-018387-ci5wx26t	37	2	,	,	,
cord-018387-ci5wx26t	37	3	it	-PRON-	PRP
cord-018387-ci5wx26t	37	4	has	have	VBZ
cord-018387-ci5wx26t	37	5	been	be	VBN
cord-018387-ci5wx26t	37	6	proposed	propose	VBN
cord-018387-ci5wx26t	37	7	that	that	IN
cord-018387-ci5wx26t	37	8	in	in	IN
cord-018387-ci5wx26t	37	9	the	the	DT
cord-018387-ci5wx26t	37	10	adipose	adipose	JJ
cord-018387-ci5wx26t	37	11	tissue	tissue	NN
cord-018387-ci5wx26t	37	12	,	,	,
cord-018387-ci5wx26t	37	13	a	a	DT
cord-018387-ci5wx26t	37	14	phenotypic	phenotypic	NN
cord-018387-ci5wx26t	37	15	switch	switch	NN
cord-018387-ci5wx26t	37	16	takes	take	VBZ
cord-018387-ci5wx26t	37	17	place	place	NN
cord-018387-ci5wx26t	37	18	toward	toward	IN
cord-018387-ci5wx26t	37	19	the	the	DT
cord-018387-ci5wx26t	37	20	macrophages	macrophage	NNS
cord-018387-ci5wx26t	37	21	of	of	IN
cord-018387-ci5wx26t	37	22	M1-phenotype	M1-phenotype	NNS
cord-018387-ci5wx26t	37	23	,	,	,
cord-018387-ci5wx26t	37	24	promoting	promote	VBG
cord-018387-ci5wx26t	37	25	the	the	DT
cord-018387-ci5wx26t	37	26	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	37	27	state	state	NN
cord-018387-ci5wx26t	37	28	.	.	.
cord-018387-ci5wx26t	38	1	This	this	DT
cord-018387-ci5wx26t	38	2	low	low	JJ
cord-018387-ci5wx26t	38	3	-	-	HYPH
cord-018387-ci5wx26t	38	4	grade	grade	NN
cord-018387-ci5wx26t	38	5	systemic	systemic	JJ
cord-018387-ci5wx26t	38	6	inflammation	inflammation	NN
cord-018387-ci5wx26t	38	7	is	be	VBZ
cord-018387-ci5wx26t	38	8	known	know	VBN
cord-018387-ci5wx26t	38	9	to	to	TO
cord-018387-ci5wx26t	38	10	be	be	VB
cord-018387-ci5wx26t	38	11	associated	associate	VBN
cord-018387-ci5wx26t	38	12	with	with	IN
cord-018387-ci5wx26t	38	13	the	the	DT
cord-018387-ci5wx26t	38	14	development	development	NN
cord-018387-ci5wx26t	38	15	of	of	IN
cord-018387-ci5wx26t	38	16	atherosclerosis	atherosclerosis	NN
cord-018387-ci5wx26t	38	17	,	,	,
cord-018387-ci5wx26t	38	18	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	38	19	,	,	,
cord-018387-ci5wx26t	38	20	insulin	insulin	NN
cord-018387-ci5wx26t	38	21	resistance	resistance	NN
cord-018387-ci5wx26t	38	22	,	,	,
cord-018387-ci5wx26t	38	23	and	and	CC
cord-018387-ci5wx26t	38	24	the	the	DT
cord-018387-ci5wx26t	38	25	promotion	promotion	NN
cord-018387-ci5wx26t	38	26	of	of	IN
cord-018387-ci5wx26t	38	27	tumor	tumor	NN
cord-018387-ci5wx26t	38	28	growth	growth	NN
cord-018387-ci5wx26t	38	29	[	[	-LRB-
cord-018387-ci5wx26t	38	30	10	10	CD
cord-018387-ci5wx26t	38	31	]	]	-RRB-
cord-018387-ci5wx26t	38	32	.	.	.
cord-018387-ci5wx26t	39	1	It	-PRON-	PRP
cord-018387-ci5wx26t	39	2	was	be	VBD
cord-018387-ci5wx26t	39	3	also	also	RB
cord-018387-ci5wx26t	39	4	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	39	5	that	that	IN
cord-018387-ci5wx26t	39	6	diet	diet	NN
cord-018387-ci5wx26t	39	7	-	-	HYPH
cord-018387-ci5wx26t	39	8	induced	induce	VBN
cord-018387-ci5wx26t	39	9	obesity	obesity	NN
cord-018387-ci5wx26t	39	10	recruits	recruit	NNS
cord-018387-ci5wx26t	39	11	monocytes	monocyte	VBZ
cord-018387-ci5wx26t	39	12	from	from	IN
cord-018387-ci5wx26t	39	13	the	the	DT
cord-018387-ci5wx26t	39	14	periphery	periphery	NN
cord-018387-ci5wx26t	39	15	to	to	IN
cord-018387-ci5wx26t	39	16	the	the	DT
cord-018387-ci5wx26t	39	17	brain	brain	NN
cord-018387-ci5wx26t	39	18	following	follow	VBG
cord-018387-ci5wx26t	39	19	herpes	herpes	NNP
cord-018387-ci5wx26t	39	20	simplex	simplex	NNP
cord-018387-ci5wx26t	39	21	virus	virus	NN
cord-018387-ci5wx26t	39	22	(	(	-LRB-
cord-018387-ci5wx26t	39	23	HSV)-1	HSV)-1	NNP
cord-018387-ci5wx26t	39	24	latency	latency	NN
cord-018387-ci5wx26t	39	25	in	in	IN
cord-018387-ci5wx26t	39	26	mice	mouse	NNS
cord-018387-ci5wx26t	39	27	[	[	-LRB-
cord-018387-ci5wx26t	39	28	11	11	CD
cord-018387-ci5wx26t	39	29	]	]	-RRB-
cord-018387-ci5wx26t	39	30	,	,	,
cord-018387-ci5wx26t	39	31	leading	lead	VBG
cord-018387-ci5wx26t	39	32	to	to	IN
cord-018387-ci5wx26t	39	33	an	an	DT
cord-018387-ci5wx26t	39	34	exaggerated	exaggerated	JJ
cord-018387-ci5wx26t	39	35	neuroinflammatory	neuroinflammatory	NN
cord-018387-ci5wx26t	39	36	response	response	NN
cord-018387-ci5wx26t	39	37	and	and	CC
cord-018387-ci5wx26t	39	38	the	the	DT
cord-018387-ci5wx26t	39	39	promotion	promotion	NN
cord-018387-ci5wx26t	39	40	of	of	IN
cord-018387-ci5wx26t	39	41	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	39	42	.	.	.
cord-018387-ci5wx26t	40	1	While	while	IN
cord-018387-ci5wx26t	40	2	these	these	DT
cord-018387-ci5wx26t	40	3	phenomena	phenomenon	NNS
cord-018387-ci5wx26t	40	4	are	be	VBP
cord-018387-ci5wx26t	40	5	not	not	RB
cord-018387-ci5wx26t	40	6	limited	limited	JJ
cord-018387-ci5wx26t	40	7	to	to	IN
cord-018387-ci5wx26t	40	8	the	the	DT
cord-018387-ci5wx26t	40	9	elderly	elderly	JJ
cord-018387-ci5wx26t	40	10	,	,	,
cord-018387-ci5wx26t	40	11	they	-PRON-	PRP
cord-018387-ci5wx26t	40	12	often	often	RB
cord-018387-ci5wx26t	40	13	tend	tend	VBP
cord-018387-ci5wx26t	40	14	to	to	TO
cord-018387-ci5wx26t	40	15	be	be	VB
cord-018387-ci5wx26t	40	16	exacerbated	exacerbate	VBN
cord-018387-ci5wx26t	40	17	in	in	IN
cord-018387-ci5wx26t	40	18	older	old	JJR
cord-018387-ci5wx26t	40	19	people	people	NNS
cord-018387-ci5wx26t	40	20	who	who	WP
cord-018387-ci5wx26t	40	21	,	,	,
cord-018387-ci5wx26t	40	22	for	for	IN
cord-018387-ci5wx26t	40	23	one	one	CD
cord-018387-ci5wx26t	40	24	reason	reason	NN
cord-018387-ci5wx26t	40	25	or	or	CC
cord-018387-ci5wx26t	40	26	another	another	DT
cord-018387-ci5wx26t	40	27	,	,	,
cord-018387-ci5wx26t	40	28	exercise	exercise	VB
cord-018387-ci5wx26t	40	29	less	less	JJR
cord-018387-ci5wx26t	40	30	than	than	IN
cord-018387-ci5wx26t	40	31	the	the	DT
cord-018387-ci5wx26t	40	32	young	young	JJ
cord-018387-ci5wx26t	40	33	[	[	-LRB-
cord-018387-ci5wx26t	40	34	2	2	CD
cord-018387-ci5wx26t	40	35	]	]	-RRB-
cord-018387-ci5wx26t	40	36	.	.	.
cord-018387-ci5wx26t	41	1	Thus	thus	RB
cord-018387-ci5wx26t	41	2	,	,	,
cord-018387-ci5wx26t	41	3	many	many	JJ
cord-018387-ci5wx26t	41	4	chronic	chronic	JJ
cord-018387-ci5wx26t	41	5	and	and	CC
cord-018387-ci5wx26t	41	6	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	41	7	diseases	disease	NNS
cord-018387-ci5wx26t	41	8	can	can	MD
cord-018387-ci5wx26t	41	9	be	be	VB
cord-018387-ci5wx26t	41	10	prevented	prevent	VBN
cord-018387-ci5wx26t	41	11	by	by	IN
cord-018387-ci5wx26t	41	12	changing	change	VBG
cord-018387-ci5wx26t	41	13	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	41	14	and	and	CC
cord-018387-ci5wx26t	41	15	behavioral	behavioral	JJ
cord-018387-ci5wx26t	41	16	habits	habit	NNS
cord-018387-ci5wx26t	41	17	,	,	,
cord-018387-ci5wx26t	41	18	particularly	particularly	RB
cord-018387-ci5wx26t	41	19	dietary	dietary	JJ
cord-018387-ci5wx26t	41	20	habits	habit	NNS
cord-018387-ci5wx26t	41	21	,	,	,
cord-018387-ci5wx26t	41	22	and	and	CC
cord-018387-ci5wx26t	41	23	exercise	exercise	NN
cord-018387-ci5wx26t	41	24	.	.	.
cord-018387-ci5wx26t	42	1	For	for	IN
cord-018387-ci5wx26t	42	2	example	example	NN
cord-018387-ci5wx26t	42	3	,	,	,
cord-018387-ci5wx26t	42	4	a	a	DT
cord-018387-ci5wx26t	42	5	positive	positive	JJ
cord-018387-ci5wx26t	42	6	effect	effect	NN
cord-018387-ci5wx26t	42	7	of	of	IN
cord-018387-ci5wx26t	42	8	a	a	DT
cord-018387-ci5wx26t	42	9	3-month	3-month	CD
cord-018387-ci5wx26t	42	10	regimen	regimen	NN
cord-018387-ci5wx26t	42	11	of	of	IN
cord-018387-ci5wx26t	42	12	comprehensive	comprehensive	JJ
cord-018387-ci5wx26t	42	13	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	42	14	changes	change	NNS
cord-018387-ci5wx26t	42	15	(	(	-LRB-
cord-018387-ci5wx26t	42	16	plant	plant	NN
cord-018387-ci5wx26t	42	17	-	-	HYPH
cord-018387-ci5wx26t	42	18	based	base	VBN
cord-018387-ci5wx26t	42	19	diet	diet	NN
cord-018387-ci5wx26t	42	20	,	,	,
cord-018387-ci5wx26t	42	21	moderate	moderate	JJ
cord-018387-ci5wx26t	42	22	exercise	exercise	NN
cord-018387-ci5wx26t	42	23	,	,	,
cord-018387-ci5wx26t	42	24	stress	stress	NN
cord-018387-ci5wx26t	42	25	management	management	NN
cord-018387-ci5wx26t	42	26	,	,	,
cord-018387-ci5wx26t	42	27	and	and	CC
cord-018387-ci5wx26t	42	28	improved	improve	VBN
cord-018387-ci5wx26t	42	29	social	social	JJ
cord-018387-ci5wx26t	42	30	support	support	NN
cord-018387-ci5wx26t	42	31	)	)	-RRB-
cord-018387-ci5wx26t	42	32	on	on	IN
cord-018387-ci5wx26t	42	33	increased	increase	VBN
cord-018387-ci5wx26t	42	34	telomerase	telomerase	NN
cord-018387-ci5wx26t	42	35	activity	activity	NN
cord-018387-ci5wx26t	42	36	was	be	VBD
cord-018387-ci5wx26t	42	37	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	42	38	in	in	IN
cord-018387-ci5wx26t	42	39	men	man	NNS
cord-018387-ci5wx26t	42	40	with	with	IN
cord-018387-ci5wx26t	42	41	low	low	JJ
cord-018387-ci5wx26t	42	42	-	-	HYPH
cord-018387-ci5wx26t	42	43	risk	risk	NN
cord-018387-ci5wx26t	42	44	prostate	prostate	NN
cord-018387-ci5wx26t	42	45	cancer	cancer	NN
cord-018387-ci5wx26t	42	46	.	.	.
cord-018387-ci5wx26t	43	1	After	after	IN
cord-018387-ci5wx26t	43	2	a	a	DT
cord-018387-ci5wx26t	43	3	5-year	5-year	CD
cord-018387-ci5wx26t	43	4	follow	follow	NN
cord-018387-ci5wx26t	43	5	-	-	HYPH
cord-018387-ci5wx26t	43	6	up	up	NN
cord-018387-ci5wx26t	43	7	,	,	,
cord-018387-ci5wx26t	43	8	relative	relative	JJ
cord-018387-ci5wx26t	43	9	telomere	telomere	NN
cord-018387-ci5wx26t	43	10	lengths	length	NNS
cord-018387-ci5wx26t	43	11	of	of	IN
cord-018387-ci5wx26t	43	12	lymphocytes	lymphocyte	NNS
cord-018387-ci5wx26t	43	13	were	be	VBD
cord-018387-ci5wx26t	43	14	increased	increase	VBN
cord-018387-ci5wx26t	43	15	in	in	IN
cord-018387-ci5wx26t	43	16	the	the	DT
cord-018387-ci5wx26t	43	17	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	43	18	intervention	intervention	NN
cord-018387-ci5wx26t	43	19	group	group	NN
cord-018387-ci5wx26t	43	20	and	and	CC
cord-018387-ci5wx26t	43	21	decreased	decrease	VBD
cord-018387-ci5wx26t	43	22	in	in	IN
cord-018387-ci5wx26t	43	23	the	the	DT
cord-018387-ci5wx26t	43	24	control	control	NN
cord-018387-ci5wx26t	43	25	group	group	NN
cord-018387-ci5wx26t	43	26	[	[	-LRB-
cord-018387-ci5wx26t	43	27	12	12	CD
cord-018387-ci5wx26t	43	28	]	]	-RRB-
cord-018387-ci5wx26t	43	29	.	.	.
cord-018387-ci5wx26t	44	1	According	accord	VBG
cord-018387-ci5wx26t	44	2	to	to	IN
cord-018387-ci5wx26t	44	3	the	the	DT
cord-018387-ci5wx26t	44	4	findings	finding	NNS
cord-018387-ci5wx26t	44	5	of	of	IN
cord-018387-ci5wx26t	44	6	another	another	DT
cord-018387-ci5wx26t	44	7	study	study	NN
cord-018387-ci5wx26t	44	8	on	on	IN
cord-018387-ci5wx26t	44	9	more	more	JJR
cord-018387-ci5wx26t	44	10	than	than	IN
cord-018387-ci5wx26t	44	11	23,000	23,000	CD
cord-018387-ci5wx26t	44	12	adults	adult	NNS
cord-018387-ci5wx26t	44	13	,	,	,
cord-018387-ci5wx26t	44	14	a	a	DT
cord-018387-ci5wx26t	44	15	healthy	healthy	JJ
cord-018387-ci5wx26t	44	16	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	44	17	alone	alone	RB
cord-018387-ci5wx26t	44	18	lowered	lower	VBD
cord-018387-ci5wx26t	44	19	the	the	DT
cord-018387-ci5wx26t	44	20	risk	risk	NN
cord-018387-ci5wx26t	44	21	of	of	IN
cord-018387-ci5wx26t	44	22	developing	develop	VBG
cord-018387-ci5wx26t	44	23	chronic	chronic	JJ
cord-018387-ci5wx26t	44	24	diseases	disease	NNS
cord-018387-ci5wx26t	44	25	with	with	IN
cord-018387-ci5wx26t	44	26	known	know	VBN
cord-018387-ci5wx26t	44	27	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	44	28	etiology	etiology	NN
cord-018387-ci5wx26t	44	29	by	by	IN
cord-018387-ci5wx26t	44	30	78	78	CD
cord-018387-ci5wx26t	44	31	%	%	NN
cord-018387-ci5wx26t	44	32	[	[	-LRB-
cord-018387-ci5wx26t	44	33	13	13	CD
cord-018387-ci5wx26t	44	34	]	]	-RRB-
cord-018387-ci5wx26t	44	35	.	.	.
cord-018387-ci5wx26t	45	1	Although	although	IN
cord-018387-ci5wx26t	45	2	such	such	JJ
cord-018387-ci5wx26t	45	3	changes	change	NNS
cord-018387-ci5wx26t	45	4	are	be	VBP
cord-018387-ci5wx26t	45	5	thought	think	VBN
cord-018387-ci5wx26t	45	6	to	to	TO
cord-018387-ci5wx26t	45	7	be	be	VB
cord-018387-ci5wx26t	45	8	beneficial	beneficial	JJ
cord-018387-ci5wx26t	45	9	,	,	,
cord-018387-ci5wx26t	45	10	more	more	JJR
cord-018387-ci5wx26t	45	11	investigations	investigation	NNS
cord-018387-ci5wx26t	45	12	are	be	VBP
cord-018387-ci5wx26t	45	13	needed	need	VBN
cord-018387-ci5wx26t	45	14	to	to	TO
cord-018387-ci5wx26t	45	15	confirm	confirm	VB
cord-018387-ci5wx26t	45	16	whether	whether	IN
cord-018387-ci5wx26t	45	17	this	this	DT
cord-018387-ci5wx26t	45	18	is	be	VBZ
cord-018387-ci5wx26t	45	19	really	really	RB
cord-018387-ci5wx26t	45	20	the	the	DT
cord-018387-ci5wx26t	45	21	case	case	NN
cord-018387-ci5wx26t	45	22	,	,	,
cord-018387-ci5wx26t	45	23	and	and	CC
cord-018387-ci5wx26t	45	24	the	the	DT
cord-018387-ci5wx26t	45	25	full	full	JJ
cord-018387-ci5wx26t	45	26	biological	biological	JJ
cord-018387-ci5wx26t	45	27	implications	implication	NNS
cord-018387-ci5wx26t	45	28	remain	remain	VBP
cord-018387-ci5wx26t	45	29	to	to	TO
cord-018387-ci5wx26t	45	30	be	be	VB
cord-018387-ci5wx26t	45	31	determined	determine	VBN
cord-018387-ci5wx26t	45	32	in	in	IN
cord-018387-ci5wx26t	45	33	large	large	JJ
cord-018387-ci5wx26t	45	34	RCTs	rct	NNS
cord-018387-ci5wx26t	45	35	[	[	-LRB-
cord-018387-ci5wx26t	45	36	2	2	CD
cord-018387-ci5wx26t	45	37	,	,	,
cord-018387-ci5wx26t	45	38	14	14	CD
cord-018387-ci5wx26t	45	39	]	]	-RRB-
cord-018387-ci5wx26t	45	40	.	.	.
cord-018387-ci5wx26t	46	1	Thus	thus	RB
cord-018387-ci5wx26t	46	2	,	,	,
cord-018387-ci5wx26t	46	3	recent	recent	JJ
cord-018387-ci5wx26t	46	4	studies	study	NNS
cord-018387-ci5wx26t	46	5	indicate	indicate	VBP
cord-018387-ci5wx26t	46	6	the	the	DT
cord-018387-ci5wx26t	46	7	need	need	NN
cord-018387-ci5wx26t	46	8	for	for	IN
cord-018387-ci5wx26t	46	9	a	a	DT
cord-018387-ci5wx26t	46	10	more	more	RBR
cord-018387-ci5wx26t	46	11	in	in	IN
cord-018387-ci5wx26t	46	12	-	-	HYPH
cord-018387-ci5wx26t	46	13	depth	depth	NN
cord-018387-ci5wx26t	46	14	,	,	,
cord-018387-ci5wx26t	46	15	holistic	holistic	JJ
cord-018387-ci5wx26t	46	16	approach	approach	NN
cord-018387-ci5wx26t	46	17	to	to	TO
cord-018387-ci5wx26t	46	18	determine	determine	VB
cord-018387-ci5wx26t	46	19	the	the	DT
cord-018387-ci5wx26t	46	20	optimal	optimal	JJ
cord-018387-ci5wx26t	46	21	nutritional	nutritional	JJ
cord-018387-ci5wx26t	46	22	and	and	CC
cord-018387-ci5wx26t	46	23	behavioral	behavioral	JJ
cord-018387-ci5wx26t	46	24	strategies	strategy	NNS
cord-018387-ci5wx26t	46	25	that	that	WDT
cord-018387-ci5wx26t	46	26	would	would	MD
cord-018387-ci5wx26t	46	27	maintain	maintain	VB
cord-018387-ci5wx26t	46	28	immune	immune	JJ
cord-018387-ci5wx26t	46	29	and	and	CC
cord-018387-ci5wx26t	46	30	other	other	JJ
cord-018387-ci5wx26t	46	31	physiological	physiological	JJ
cord-018387-ci5wx26t	46	32	systems	system	NNS
cord-018387-ci5wx26t	46	33	in	in	IN
cord-018387-ci5wx26t	46	34	the	the	DT
cord-018387-ci5wx26t	46	35	elderly	elderly	JJ
cord-018387-ci5wx26t	46	36	people	people	NNS
cord-018387-ci5wx26t	46	37	.	.	.
cord-018387-ci5wx26t	47	1	Superimposed	superimpose	VBN
cord-018387-ci5wx26t	47	2	on	on	IN
cord-018387-ci5wx26t	47	3	chronological	chronological	JJ
cord-018387-ci5wx26t	47	4	age	age	NN
cord-018387-ci5wx26t	47	5	alone	alone	RB
cord-018387-ci5wx26t	47	6	,	,	,
cord-018387-ci5wx26t	47	7	the	the	DT
cord-018387-ci5wx26t	47	8	remodeling	remodeling	NN
cord-018387-ci5wx26t	47	9	of	of	IN
cord-018387-ci5wx26t	47	10	immunity	immunity	NN
cord-018387-ci5wx26t	47	11	as	as	IN
cord-018387-ci5wx26t	47	12	a	a	DT
cord-018387-ci5wx26t	47	13	result	result	NN
cord-018387-ci5wx26t	47	14	of	of	IN
cord-018387-ci5wx26t	47	15	interactions	interaction	NNS
cord-018387-ci5wx26t	47	16	with	with	IN
cord-018387-ci5wx26t	47	17	the	the	DT
cord-018387-ci5wx26t	47	18	environment	environment	NN
cord-018387-ci5wx26t	47	19	over	over	IN
cord-018387-ci5wx26t	47	20	the	the	DT
cord-018387-ci5wx26t	47	21	life	life	NN
cord-018387-ci5wx26t	47	22	course	course	NN
cord-018387-ci5wx26t	47	23	is	be	VBZ
cord-018387-ci5wx26t	47	24	instrumental	instrumental	JJ
cord-018387-ci5wx26t	47	25	in	in	IN
cord-018387-ci5wx26t	47	26	shaping	shape	VBG
cord-018387-ci5wx26t	47	27	immune	immune	JJ
cord-018387-ci5wx26t	47	28	status	status	NN
cord-018387-ci5wx26t	47	29	in	in	IN
cord-018387-ci5wx26t	47	30	later	later	JJ
cord-018387-ci5wx26t	47	31	life	life	NN
cord-018387-ci5wx26t	47	32	.	.	.
cord-018387-ci5wx26t	48	1	In	in	IN
cord-018387-ci5wx26t	48	2	addition	addition	NN
cord-018387-ci5wx26t	48	3	to	to	IN
cord-018387-ci5wx26t	48	4	interactions	interaction	NNS
cord-018387-ci5wx26t	48	5	with	with	IN
cord-018387-ci5wx26t	48	6	pathogens	pathogen	NNS
cord-018387-ci5wx26t	48	7	,	,	,
cord-018387-ci5wx26t	48	8	host	host	NN
cord-018387-ci5wx26t	48	9	microbiome	microbiome	NN
cord-018387-ci5wx26t	48	10	and	and	CC
cord-018387-ci5wx26t	48	11	nutrition	nutrition	NN
cord-018387-ci5wx26t	48	12	,	,	,
cord-018387-ci5wx26t	48	13	exercise	exercise	NN
cord-018387-ci5wx26t	48	14	and	and	CC
cord-018387-ci5wx26t	48	15	stress	stress	NN
cord-018387-ci5wx26t	48	16	,	,	,
cord-018387-ci5wx26t	48	17	and	and	CC
cord-018387-ci5wx26t	48	18	many	many	JJ
cord-018387-ci5wx26t	48	19	other	other	JJ
cord-018387-ci5wx26t	48	20	extrinsic	extrinsic	JJ
cord-018387-ci5wx26t	48	21	factors	factor	NNS
cord-018387-ci5wx26t	48	22	are	be	VBP
cord-018387-ci5wx26t	48	23	crucial	crucial	JJ
cord-018387-ci5wx26t	48	24	modulators	modulator	NNS
cord-018387-ci5wx26t	48	25	of	of	IN
cord-018387-ci5wx26t	48	26	this	this	DT
cord-018387-ci5wx26t	48	27	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	48	28	process	process	NN
cord-018387-ci5wx26t	48	29	[	[	-LRB-
cord-018387-ci5wx26t	48	30	2	2	CD
cord-018387-ci5wx26t	48	31	]	]	-RRB-
cord-018387-ci5wx26t	48	32	.	.	.
cord-018387-ci5wx26t	49	1	In	in	IN
cord-018387-ci5wx26t	49	2	the	the	DT
cord-018387-ci5wx26t	49	3	next	next	JJ
cord-018387-ci5wx26t	49	4	sections	section	NNS
cord-018387-ci5wx26t	49	5	,	,	,
cord-018387-ci5wx26t	49	6	we	-PRON-	PRP
cord-018387-ci5wx26t	49	7	briefly	briefly	RB
cord-018387-ci5wx26t	49	8	describe	describe	VBP
cord-018387-ci5wx26t	49	9	the	the	DT
cord-018387-ci5wx26t	49	10	observed	observe	VBN
cord-018387-ci5wx26t	49	11	agerelated	agerelate	VBN
cord-018387-ci5wx26t	49	12	changes	change	NNS
cord-018387-ci5wx26t	49	13	in	in	IN
cord-018387-ci5wx26t	49	14	the	the	DT
cord-018387-ci5wx26t	49	15	immune	immune	JJ
cord-018387-ci5wx26t	49	16	system	system	NN
cord-018387-ci5wx26t	49	17	and	and	CC
cord-018387-ci5wx26t	49	18	then	then	RB
cord-018387-ci5wx26t	49	19	outline	outline	VB
cord-018387-ci5wx26t	49	20	the	the	DT
cord-018387-ci5wx26t	49	21	possible	possible	JJ
cord-018387-ci5wx26t	49	22	contribution	contribution	NN
cord-018387-ci5wx26t	49	23	of	of	IN
cord-018387-ci5wx26t	49	24	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	49	25	and	and	CC
cord-018387-ci5wx26t	49	26	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	49	27	to	to	IN
cord-018387-ci5wx26t	49	28	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	49	29	and	and	CC
cord-018387-ci5wx26t	49	30	finally	finally	RB
cord-018387-ci5wx26t	49	31	discuss	discuss	VB
cord-018387-ci5wx26t	49	32	the	the	DT
cord-018387-ci5wx26t	49	33	modulatory	modulatory	JJ
cord-018387-ci5wx26t	49	34	potential	potential	NN
cord-018387-ci5wx26t	49	35	of	of	IN
cord-018387-ci5wx26t	49	36	nutrition	nutrition	NN
cord-018387-ci5wx26t	49	37	and	and	CC
cord-018387-ci5wx26t	49	38	active	active	JJ
cord-018387-ci5wx26t	49	39	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	49	40	thereon	thereon	NN
cord-018387-ci5wx26t	49	41	.	.	.
cord-018387-ci5wx26t	50	1	Human	human	JJ
cord-018387-ci5wx26t	50	2	immune	immune	JJ
cord-018387-ci5wx26t	50	3	aging	aging	NN
cord-018387-ci5wx26t	50	4	represents	represent	VBZ
cord-018387-ci5wx26t	50	5	a	a	DT
cord-018387-ci5wx26t	50	6	universal	universal	JJ
cord-018387-ci5wx26t	50	7	and	and	CC
cord-018387-ci5wx26t	50	8	multifaceted	multifaceted	JJ
cord-018387-ci5wx26t	50	9	process	process	NN
cord-018387-ci5wx26t	50	10	characterized	characterize	VBN
cord-018387-ci5wx26t	50	11	by	by	IN
cord-018387-ci5wx26t	50	12	progressive	progressive	JJ
cord-018387-ci5wx26t	50	13	immunodeficiency	immunodeficiency	NN
cord-018387-ci5wx26t	50	14	,	,	,
cord-018387-ci5wx26t	50	15	chronic	chronic	JJ
cord-018387-ci5wx26t	50	16	inflammation	inflammation	NN
cord-018387-ci5wx26t	50	17	,	,	,
cord-018387-ci5wx26t	50	18	and	and	CC
cord-018387-ci5wx26t	50	19	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	50	20	[	[	-LRB-
cord-018387-ci5wx26t	50	21	15	15	CD
cord-018387-ci5wx26t	50	22	,	,	,
cord-018387-ci5wx26t	50	23	16	16	CD
cord-018387-ci5wx26t	50	24	]	]	-RRB-
cord-018387-ci5wx26t	50	25	.	.	.
cord-018387-ci5wx26t	51	1	The	the	DT
cord-018387-ci5wx26t	51	2	complex	complex	JJ
cord-018387-ci5wx26t	51	3	regulatory	regulatory	JJ
cord-018387-ci5wx26t	51	4	circuits	circuit	NNS
cord-018387-ci5wx26t	51	5	required	require	VBN
cord-018387-ci5wx26t	51	6	for	for	IN
cord-018387-ci5wx26t	51	7	maintaining	maintain	VBG
cord-018387-ci5wx26t	51	8	appropriate	appropriate	JJ
cord-018387-ci5wx26t	51	9	physiological	physiological	JJ
cord-018387-ci5wx26t	51	10	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	51	11	may	may	MD
cord-018387-ci5wx26t	51	12	become	become	VB
cord-018387-ci5wx26t	51	13	compromised	compromise	VBN
cord-018387-ci5wx26t	51	14	with	with	IN
cord-018387-ci5wx26t	51	15	aging	age	VBG
cord-018387-ci5wx26t	51	16	[	[	-LRB-
cord-018387-ci5wx26t	51	17	17	17	CD
cord-018387-ci5wx26t	51	18	,	,	,
cord-018387-ci5wx26t	51	19	18	18	CD
cord-018387-ci5wx26t	51	20	]	]	-RRB-
cord-018387-ci5wx26t	51	21	.	.	.
cord-018387-ci5wx26t	52	1	Age	age	NN
cord-018387-ci5wx26t	52	2	-	-	HYPH
cord-018387-ci5wx26t	52	3	related	relate	VBN
cord-018387-ci5wx26t	52	4	immune	immune	JJ
cord-018387-ci5wx26t	52	5	dysfunction	dysfunction	NN
cord-018387-ci5wx26t	52	6	(	(	-LRB-
cord-018387-ci5wx26t	52	7	in	in	IN
cord-018387-ci5wx26t	52	8	combination	combination	NN
cord-018387-ci5wx26t	52	9	with	with	IN
cord-018387-ci5wx26t	52	10	other	other	JJ
cord-018387-ci5wx26t	52	11	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	52	12	)	)	-RRB-
cord-018387-ci5wx26t	52	13	may	may	MD
cord-018387-ci5wx26t	52	14	at	at	IN
cord-018387-ci5wx26t	52	15	least	least	JJS
cord-018387-ci5wx26t	52	16	in	in	IN
cord-018387-ci5wx26t	52	17	part	part	NN
cord-018387-ci5wx26t	52	18	explain	explain	VB
cord-018387-ci5wx26t	52	19	the	the	DT
cord-018387-ci5wx26t	52	20	process	process	NN
cord-018387-ci5wx26t	52	21	of	of	IN
cord-018387-ci5wx26t	52	22	aging	age	VBG
cord-018387-ci5wx26t	52	23	itself	-PRON-	PRP
cord-018387-ci5wx26t	52	24	[	[	-LRB-
cord-018387-ci5wx26t	52	25	19	19	CD
cord-018387-ci5wx26t	52	26	]	]	-RRB-
cord-018387-ci5wx26t	52	27	,	,	,
cord-018387-ci5wx26t	52	28	as	as	IN
cord-018387-ci5wx26t	52	29	originally	originally	RB
cord-018387-ci5wx26t	52	30	proposed	propose	VBN
cord-018387-ci5wx26t	52	31	by	by	IN
cord-018387-ci5wx26t	52	32	Walford	Walford	NNP
cord-018387-ci5wx26t	52	33	in	in	IN
cord-018387-ci5wx26t	52	34	1969	1969	CD
cord-018387-ci5wx26t	52	35	[	[	-LRB-
cord-018387-ci5wx26t	52	36	20	20	CD
cord-018387-ci5wx26t	52	37	]	]	-RRB-
cord-018387-ci5wx26t	52	38	.	.	.
cord-018387-ci5wx26t	53	1	In	in	IN
cord-018387-ci5wx26t	53	2	the	the	DT
cord-018387-ci5wx26t	53	3	course	course	NN
cord-018387-ci5wx26t	53	4	of	of	IN
cord-018387-ci5wx26t	53	5	aging	age	VBG
cord-018387-ci5wx26t	53	6	,	,	,
cord-018387-ci5wx26t	53	7	our	-PRON-	PRP$
cord-018387-ci5wx26t	53	8	immune	immune	JJ
cord-018387-ci5wx26t	53	9	system	system	NN
cord-018387-ci5wx26t	53	10	undergoes	undergo	VBZ
cord-018387-ci5wx26t	53	11	an	an	DT
cord-018387-ci5wx26t	53	12	imprecisely	imprecisely	RB
cord-018387-ci5wx26t	53	13	defined	define	VBN
cord-018387-ci5wx26t	53	14	process	process	NN
cord-018387-ci5wx26t	53	15	of	of	IN
cord-018387-ci5wx26t	53	16	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	53	17	that	that	WDT
cord-018387-ci5wx26t	53	18	affects	affect	VBZ
cord-018387-ci5wx26t	53	19	both	both	CC
cord-018387-ci5wx26t	53	20	adaptive	adaptive	JJ
cord-018387-ci5wx26t	53	21	and	and	CC
cord-018387-ci5wx26t	53	22	innate	innate	JJ
cord-018387-ci5wx26t	53	23	immune	immune	JJ
cord-018387-ci5wx26t	53	24	systems	system	NNS
cord-018387-ci5wx26t	53	25	.	.	.
cord-018387-ci5wx26t	54	1	The	the	DT
cord-018387-ci5wx26t	54	2	most	most	RBS
cord-018387-ci5wx26t	54	3	marked	marked	JJ
cord-018387-ci5wx26t	54	4	changes	change	NNS
cord-018387-ci5wx26t	54	5	in	in	IN
cord-018387-ci5wx26t	54	6	adaptive	adaptive	JJ
cord-018387-ci5wx26t	54	7	immunity	immunity	NN
cord-018387-ci5wx26t	54	8	are	be	VBP
cord-018387-ci5wx26t	54	9	decreased	decrease	VBN
cord-018387-ci5wx26t	54	10	numbers	number	NNS
cord-018387-ci5wx26t	54	11	of	of	IN
cord-018387-ci5wx26t	54	12	peripheral	peripheral	JJ
cord-018387-ci5wx26t	54	13	naïve	naïve	JJ
cord-018387-ci5wx26t	54	14	T	T	NNP
cord-018387-ci5wx26t	54	15	cells	cell	NNS
cord-018387-ci5wx26t	54	16	and	and	CC
cord-018387-ci5wx26t	54	17	the	the	DT
cord-018387-ci5wx26t	54	18	concomitant	concomitant	JJ
cord-018387-ci5wx26t	54	19	accumulation	accumulation	NN
cord-018387-ci5wx26t	54	20	of	of	IN
cord-018387-ci5wx26t	54	21	late	late	JJ
cord-018387-ci5wx26t	54	22	-	-	HYPH
cord-018387-ci5wx26t	54	23	stage	stage	NN
cord-018387-ci5wx26t	54	24	differentiated	differentiate	VBN
cord-018387-ci5wx26t	54	25	memory	memory	NN
cord-018387-ci5wx26t	54	26	T	T	NNP
cord-018387-ci5wx26t	54	27	cells	cell	NNS
cord-018387-ci5wx26t	54	28	[	[	-LRB-
cord-018387-ci5wx26t	54	29	18	18	CD
cord-018387-ci5wx26t	54	30	,	,	,
cord-018387-ci5wx26t	54	31	[	[	-LRB-
cord-018387-ci5wx26t	54	32	21	21	CD
cord-018387-ci5wx26t	54	33	]	]	-RRB-
cord-018387-ci5wx26t	54	34	[	[	-LRB-
cord-018387-ci5wx26t	54	35	22	22	CD
cord-018387-ci5wx26t	54	36	]	]	-RRB-
cord-018387-ci5wx26t	54	37	[	[	-LRB-
cord-018387-ci5wx26t	54	38	23	23	CD
cord-018387-ci5wx26t	54	39	]	]	-RRB-
cord-018387-ci5wx26t	55	1	[	[	-LRB-
cord-018387-ci5wx26t	55	2	24	24	CD
cord-018387-ci5wx26t	55	3	]	]	-RRB-
cord-018387-ci5wx26t	55	4	[	[	-LRB-
cord-018387-ci5wx26t	55	5	25	25	CD
cord-018387-ci5wx26t	55	6	]	]	-RRB-
cord-018387-ci5wx26t	55	7	[	[	-LRB-
cord-018387-ci5wx26t	55	8	26	26	CD
cord-018387-ci5wx26t	55	9	]	]	-RRB-
cord-018387-ci5wx26t	55	10	[	[	-LRB-
cord-018387-ci5wx26t	55	11	27	27	CD
cord-018387-ci5wx26t	55	12	]	]	-RRB-
cord-018387-ci5wx26t	56	1	[	[	-LRB-
cord-018387-ci5wx26t	56	2	28	28	CD
cord-018387-ci5wx26t	56	3	]	]	-RRB-
cord-018387-ci5wx26t	56	4	with	with	IN
cord-018387-ci5wx26t	56	5	reduced	reduce	VBN
cord-018387-ci5wx26t	56	6	antigen	antigen	NN
cord-018387-ci5wx26t	56	7	receptor	receptor	NN
cord-018387-ci5wx26t	56	8	repertoire	repertoire	NN
cord-018387-ci5wx26t	56	9	diversity	diversity	NN
cord-018387-ci5wx26t	56	10	[	[	-LRB-
cord-018387-ci5wx26t	56	11	26	26	CD
cord-018387-ci5wx26t	56	12	,	,	,
cord-018387-ci5wx26t	56	13	[	[	-LRB-
cord-018387-ci5wx26t	56	14	29	29	CD
cord-018387-ci5wx26t	56	15	]	]	-RRB-
cord-018387-ci5wx26t	57	1	[	[	-LRB-
cord-018387-ci5wx26t	57	2	30	30	CD
cord-018387-ci5wx26t	57	3	]	]	-RRB-
cord-018387-ci5wx26t	58	1	[	[	-LRB-
cord-018387-ci5wx26t	58	2	31	31	CD
cord-018387-ci5wx26t	58	3	]	]	-RRB-
cord-018387-ci5wx26t	59	1	(	(	-LRB-
cord-018387-ci5wx26t	59	2	Figs	fig	NNS
cord-018387-ci5wx26t	59	3	.	.	.
cord-018387-ci5wx26t	60	1	14.1	14.1	CD
cord-018387-ci5wx26t	60	2	and	and	CC
cord-018387-ci5wx26t	60	3	14.2	14.2	CD
cord-018387-ci5wx26t	60	4	)	)	-RRB-
cord-018387-ci5wx26t	60	5	.	.	.
cord-018387-ci5wx26t	61	1	This	this	DT
cord-018387-ci5wx26t	61	2	phenomenon	phenomenon	NN
cord-018387-ci5wx26t	61	3	results	result	VBZ
cord-018387-ci5wx26t	61	4	from	from	IN
cord-018387-ci5wx26t	61	5	poorly	poorly	RB
cord-018387-ci5wx26t	61	6	understood	understand	VBN
cord-018387-ci5wx26t	61	7	age	age	NN
cord-018387-ci5wx26t	61	8	-	-	HYPH
cord-018387-ci5wx26t	61	9	related	relate	VBN
cord-018387-ci5wx26t	61	10	impairments	impairment	NNS
cord-018387-ci5wx26t	61	11	in	in	IN
cord-018387-ci5wx26t	61	12	the	the	DT
cord-018387-ci5wx26t	61	13	hematopoietic	hematopoietic	JJ
cord-018387-ci5wx26t	61	14	stem	stem	NN
cord-018387-ci5wx26t	61	15	cell	cell	NN
cord-018387-ci5wx26t	61	16	(	(	-LRB-
cord-018387-ci5wx26t	61	17	HSC	HSC	NNP
cord-018387-ci5wx26t	61	18	)	)	-RRB-
cord-018387-ci5wx26t	61	19	compartment	compartment	NN
cord-018387-ci5wx26t	61	20	which	which	WDT
cord-018387-ci5wx26t	61	21	generates	generate	VBZ
cord-018387-ci5wx26t	61	22	fewer	few	JJR
cord-018387-ci5wx26t	61	23	T	t	NN
cord-018387-ci5wx26t	61	24	-	-	HYPH
cord-018387-ci5wx26t	61	25	cell	cell	NN
cord-018387-ci5wx26t	61	26	precursors	precursor	NNS
cord-018387-ci5wx26t	61	27	in	in	IN
cord-018387-ci5wx26t	61	28	adult	adult	NN
cord-018387-ci5wx26t	61	29	and	and	CC
cord-018387-ci5wx26t	61	30	later	later	JJ
cord-018387-ci5wx26t	61	31	life	life	NN
cord-018387-ci5wx26t	61	32	,	,	,
cord-018387-ci5wx26t	61	33	on	on	IN
cord-018387-ci5wx26t	61	34	the	the	DT
cord-018387-ci5wx26t	61	35	one	one	CD
cord-018387-ci5wx26t	61	36	hand	hand	NN
cord-018387-ci5wx26t	61	37	,	,	,
cord-018387-ci5wx26t	61	38	and	and	CC
cord-018387-ci5wx26t	61	39	thymic	thymic	JJ
cord-018387-ci5wx26t	61	40	involution	involution	NN
cord-018387-ci5wx26t	61	41	at	at	IN
cord-018387-ci5wx26t	61	42	puberty	puberty	NN
cord-018387-ci5wx26t	61	43	which	which	WDT
cord-018387-ci5wx26t	61	44	markedly	markedly	RB
cord-018387-ci5wx26t	61	45	reduces	reduce	VBZ
cord-018387-ci5wx26t	61	46	the	the	DT
cord-018387-ci5wx26t	61	47	production	production	NN
cord-018387-ci5wx26t	61	48	of	of	IN
cord-018387-ci5wx26t	61	49	mature	mature	JJ
cord-018387-ci5wx26t	61	50	T	t	NN
cord-018387-ci5wx26t	61	51	cells	cell	NNS
cord-018387-ci5wx26t	61	52	from	from	IN
cord-018387-ci5wx26t	61	53	their	-PRON-	PRP$
cord-018387-ci5wx26t	61	54	precursors	precursor	NNS
cord-018387-ci5wx26t	61	55	,	,	,
cord-018387-ci5wx26t	61	56	on	on	IN
cord-018387-ci5wx26t	61	57	the	the	DT
cord-018387-ci5wx26t	61	58	other	other	JJ
cord-018387-ci5wx26t	61	59	hand	hand	NN
cord-018387-ci5wx26t	61	60	[	[	-LRB-
cord-018387-ci5wx26t	61	61	32	32	CD
cord-018387-ci5wx26t	61	62	]	]	-RRB-
cord-018387-ci5wx26t	61	63	.	.	.
cord-018387-ci5wx26t	62	1	The	the	DT
cord-018387-ci5wx26t	62	2	HSC	HSC	NNP
cord-018387-ci5wx26t	62	3	compartment	compartment	NN
cord-018387-ci5wx26t	62	4	(	(	-LRB-
cord-018387-ci5wx26t	62	5	Fig	Fig	NNP
cord-018387-ci5wx26t	62	6	.	.	NNP
cord-018387-ci5wx26t	62	7	14.1	14.1	CD
cord-018387-ci5wx26t	62	8	)	)	-RRB-
cord-018387-ci5wx26t	62	9	is	be	VBZ
cord-018387-ci5wx26t	62	10	negatively	negatively	RB
cord-018387-ci5wx26t	62	11	modulated	modulate	VBN
cord-018387-ci5wx26t	62	12	and	and	CC
cord-018387-ci5wx26t	62	13	functionally	functionally	RB
cord-018387-ci5wx26t	62	14	affected	affect	VBN
cord-018387-ci5wx26t	62	15	by	by	IN
cord-018387-ci5wx26t	62	16	aging	age	VBG
cord-018387-ci5wx26t	62	17	[	[	-LRB-
cord-018387-ci5wx26t	62	18	33	33	CD
cord-018387-ci5wx26t	62	19	]	]	-RRB-
cord-018387-ci5wx26t	62	20	and	and	CC
cord-018387-ci5wx26t	62	21	is	be	VBZ
cord-018387-ci5wx26t	62	22	increasingly	increasingly	RB
cord-018387-ci5wx26t	62	23	substituted	substitute	VBN
cord-018387-ci5wx26t	62	24	by	by	IN
cord-018387-ci5wx26t	62	25	adipose	adipose	JJ
cord-018387-ci5wx26t	62	26	tissue	tissue	NN
cord-018387-ci5wx26t	62	27	[	[	-LRB-
cord-018387-ci5wx26t	62	28	18	18	CD
cord-018387-ci5wx26t	62	29	,	,	,
cord-018387-ci5wx26t	62	30	34	34	CD
cord-018387-ci5wx26t	62	31	,	,	,
cord-018387-ci5wx26t	62	32	35	35	CD
cord-018387-ci5wx26t	62	33	]	]	-RRB-
cord-018387-ci5wx26t	62	34	.	.	.
cord-018387-ci5wx26t	63	1	Age	age	NN
cord-018387-ci5wx26t	63	2	-	-	HYPH
cord-018387-ci5wx26t	63	3	related	relate	VBN
cord-018387-ci5wx26t	63	4	modification	modification	NN
cord-018387-ci5wx26t	63	5	within	within	IN
cord-018387-ci5wx26t	63	6	the	the	DT
cord-018387-ci5wx26t	63	7	HSC	HSC	NNP
cord-018387-ci5wx26t	63	8	compartment	compartment	NN
cord-018387-ci5wx26t	63	9	may	may	MD
cord-018387-ci5wx26t	63	10	be	be	VB
cord-018387-ci5wx26t	63	11	partly	partly	RB
cord-018387-ci5wx26t	63	12	due	due	JJ
cord-018387-ci5wx26t	63	13	to	to	IN
cord-018387-ci5wx26t	63	14	the	the	DT
cord-018387-ci5wx26t	63	15	"	"	``
cord-018387-ci5wx26t	63	16	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	63	17	cellular	cellular	JJ
cord-018387-ci5wx26t	63	18	aging	aging	NN
cord-018387-ci5wx26t	63	19	"	"	''
cord-018387-ci5wx26t	63	20	of	of	IN
cord-018387-ci5wx26t	63	21	HSCs	hsc	VBG
cord-018387-ci5wx26t	63	22	themselves	-PRON-	PRP
cord-018387-ci5wx26t	63	23	.	.	.
cord-018387-ci5wx26t	64	1	Aged	aged	JJ
cord-018387-ci5wx26t	64	2	HSCs	hsc	NNS
cord-018387-ci5wx26t	64	3	demonstrate	demonstrate	VBP
cord-018387-ci5wx26t	64	4	more	more	RBR
cord-018387-ci5wx26t	64	5	accumulated	accumulate	VBN
cord-018387-ci5wx26t	64	6	DNA	dna	NN
cord-018387-ci5wx26t	64	7	damage	damage	NN
cord-018387-ci5wx26t	64	8	,	,	,
cord-018387-ci5wx26t	64	9	telomere	telomere	NN
cord-018387-ci5wx26t	64	10	attrition	attrition	NN
cord-018387-ci5wx26t	64	11	,	,	,
cord-018387-ci5wx26t	64	12	and	and	CC
cord-018387-ci5wx26t	64	13	epigenetic	epigenetic	JJ
cord-018387-ci5wx26t	64	14	deregulation	deregulation	NN
cord-018387-ci5wx26t	64	15	,	,	,
cord-018387-ci5wx26t	64	16	often	often	RB
cord-018387-ci5wx26t	64	17	in	in	IN
cord-018387-ci5wx26t	64	18	combination	combination	NN
cord-018387-ci5wx26t	64	19	with	with	IN
cord-018387-ci5wx26t	64	20	an	an	DT
cord-018387-ci5wx26t	64	21	increase	increase	NN
cord-018387-ci5wx26t	64	22	in	in	IN
cord-018387-ci5wx26t	64	23	intracellular	intracellular	JJ
cord-018387-ci5wx26t	64	24	reactive	reactive	JJ
cord-018387-ci5wx26t	64	25	oxygen	oxygen	NN
cord-018387-ci5wx26t	64	26	species	specie	NNS
cord-018387-ci5wx26t	64	27	(	(	-LRB-
cord-018387-ci5wx26t	64	28	ROS	ROS	NNP
cord-018387-ci5wx26t	64	29	)	)	-RRB-
cord-018387-ci5wx26t	64	30	[	[	-LRB-
cord-018387-ci5wx26t	64	31	2	2	CD
cord-018387-ci5wx26t	64	32	,	,	,
cord-018387-ci5wx26t	64	33	36	36	CD
cord-018387-ci5wx26t	64	34	]	]	-RRB-
cord-018387-ci5wx26t	64	35	.	.	.
cord-018387-ci5wx26t	65	1	Such	such	JJ
cord-018387-ci5wx26t	65	2	events	event	NNS
cord-018387-ci5wx26t	65	3	may	may	MD
cord-018387-ci5wx26t	65	4	also	also	RB
cord-018387-ci5wx26t	65	5	lead	lead	VB
cord-018387-ci5wx26t	65	6	to	to	IN
cord-018387-ci5wx26t	65	7	progressive	progressive	JJ
cord-018387-ci5wx26t	65	8	myeloproliferative	myeloproliferative	JJ
cord-018387-ci5wx26t	65	9	disorders	disorder	NNS
cord-018387-ci5wx26t	65	10	and	and	CC
cord-018387-ci5wx26t	65	11	the	the	DT
cord-018387-ci5wx26t	65	12	malignant	malignant	JJ
cord-018387-ci5wx26t	65	13	transformation	transformation	NN
cord-018387-ci5wx26t	65	14	of	of	IN
cord-018387-ci5wx26t	65	15	HSCs	HSCs	NNP
cord-018387-ci5wx26t	65	16	.	.	.
cord-018387-ci5wx26t	66	1	In	in	IN
cord-018387-ci5wx26t	66	2	addition	addition	NN
cord-018387-ci5wx26t	66	3	to	to	IN
cord-018387-ci5wx26t	66	4	such	such	JJ
cord-018387-ci5wx26t	66	5	"	"	``
cord-018387-ci5wx26t	66	6	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	66	7	"	"	''
cord-018387-ci5wx26t	66	8	HSC	HSC	NNP
cord-018387-ci5wx26t	66	9	age	age	NN
cord-018387-ci5wx26t	66	10	effects	effect	NNS
cord-018387-ci5wx26t	66	11	,	,	,
cord-018387-ci5wx26t	66	12	the	the	DT
cord-018387-ci5wx26t	66	13	extracellular	extracellular	JJ
cord-018387-ci5wx26t	66	14	and	and	CC
cord-018387-ci5wx26t	66	15	stromal	stromal	JJ
cord-018387-ci5wx26t	66	16	matrix	matrix	NN
cord-018387-ci5wx26t	66	17	of	of	IN
cord-018387-ci5wx26t	66	18	the	the	DT
cord-018387-ci5wx26t	66	19	aging	age	VBG
cord-018387-ci5wx26t	66	20	bone	bone	NN
cord-018387-ci5wx26t	66	21	marrow	marrow	NN
cord-018387-ci5wx26t	66	22	(	(	-LRB-
cord-018387-ci5wx26t	66	23	which	which	WDT
cord-018387-ci5wx26t	66	24	normally	normally	RB
cord-018387-ci5wx26t	66	25	nurtures	nurture	VBZ
cord-018387-ci5wx26t	66	26	and	and	CC
cord-018387-ci5wx26t	66	27	drives	drive	VBZ
cord-018387-ci5wx26t	66	28	stem	stem	VBP
cord-018387-ci5wx26t	66	29	cell	cell	NN
cord-018387-ci5wx26t	66	30	production	production	NN
cord-018387-ci5wx26t	66	31	)	)	-RRB-
cord-018387-ci5wx26t	66	32	also	also	RB
cord-018387-ci5wx26t	66	33	undergoes	undergo	VBZ
cord-018387-ci5wx26t	66	34	dramatic	dramatic	JJ
cord-018387-ci5wx26t	66	35	structural	structural	JJ
cord-018387-ci5wx26t	66	36	changes	change	NNS
cord-018387-ci5wx26t	66	37	in	in	IN
cord-018387-ci5wx26t	66	38	terms	term	NNS
cord-018387-ci5wx26t	66	39	of	of	IN
cord-018387-ci5wx26t	66	40	the	the	DT
cord-018387-ci5wx26t	66	41	numbers	number	NNS
cord-018387-ci5wx26t	66	42	of	of	IN
cord-018387-ci5wx26t	66	43	stromal	stromal	JJ
cord-018387-ci5wx26t	66	44	cells	cell	NNS
cord-018387-ci5wx26t	66	45	and	and	CC
cord-018387-ci5wx26t	66	46	osteoblasts	osteoblast	NNS
cord-018387-ci5wx26t	66	47	and	and	CC
cord-018387-ci5wx26t	66	48	reduced	reduce	VBN
cord-018387-ci5wx26t	66	49	production	production	NN
cord-018387-ci5wx26t	66	50	of	of	IN
cord-018387-ci5wx26t	66	51	IL-7	IL-7	NNP
cord-018387-ci5wx26t	66	52	(	(	-LRB-
cord-018387-ci5wx26t	66	53	Fig	Fig	NNP
cord-018387-ci5wx26t	66	54	.	.	NNP
cord-018387-ci5wx26t	66	55	14.1	14.1	CD
cord-018387-ci5wx26t	66	56	)	)	-RRB-
cord-018387-ci5wx26t	66	57	.	.	.
cord-018387-ci5wx26t	67	1	The	the	DT
cord-018387-ci5wx26t	67	2	aged	aged	JJ
cord-018387-ci5wx26t	67	3	pool	pool	NN
cord-018387-ci5wx26t	67	4	of	of	IN
cord-018387-ci5wx26t	67	5	HSCs	hscs	NN
cord-018387-ci5wx26t	67	6	is	be	VBZ
cord-018387-ci5wx26t	67	7	often	often	RB
cord-018387-ci5wx26t	67	8	characterized	characterize	VBN
cord-018387-ci5wx26t	67	9	by	by	IN
cord-018387-ci5wx26t	67	10	a	a	DT
cord-018387-ci5wx26t	67	11	marked	marked	JJ
cord-018387-ci5wx26t	67	12	shift	shift	NN
cord-018387-ci5wx26t	67	13	in	in	IN
cord-018387-ci5wx26t	67	14	lymphoid	lymphoid	JJ
cord-018387-ci5wx26t	67	15	and	and	CC
cord-018387-ci5wx26t	67	16	myeloid	myeloid	JJ
cord-018387-ci5wx26t	67	17	lineage	lineage	NN
cord-018387-ci5wx26t	67	18	output	output	NN
cord-018387-ci5wx26t	67	19	.	.	.
cord-018387-ci5wx26t	68	1	Such	such	JJ
cord-018387-ci5wx26t	68	2	age	age	NN
cord-018387-ci5wx26t	68	3	-	-	HYPH
cord-018387-ci5wx26t	68	4	associated	associate	VBN
cord-018387-ci5wx26t	68	5	myeloid	myeloid	NN
cord-018387-ci5wx26t	68	6	skewing	skewing	NN
cord-018387-ci5wx26t	68	7	of	of	IN
cord-018387-ci5wx26t	68	8	the	the	DT
cord-018387-ci5wx26t	68	9	differentiation	differentiation	NN
cord-018387-ci5wx26t	68	10	potential	potential	NN
cord-018387-ci5wx26t	68	11	,	,	,
cord-018387-ci5wx26t	68	12	together	together	RB
cord-018387-ci5wx26t	68	13	with	with	IN
cord-018387-ci5wx26t	68	14	decreased	decrease	VBN
cord-018387-ci5wx26t	68	15	homing	homing	NN
cord-018387-ci5wx26t	68	16	efficiency	efficiency	NN
cord-018387-ci5wx26t	68	17	,	,	,
cord-018387-ci5wx26t	68	18	contributes	contribute	VBZ
cord-018387-ci5wx26t	68	19	to	to	IN
cord-018387-ci5wx26t	68	20	changes	change	NNS
cord-018387-ci5wx26t	68	21	in	in	IN
cord-018387-ci5wx26t	68	22	the	the	DT
cord-018387-ci5wx26t	68	23	cellular	cellular	JJ
cord-018387-ci5wx26t	68	24	composition	composition	NN
cord-018387-ci5wx26t	68	25	of	of	IN
cord-018387-ci5wx26t	68	26	the	the	DT
cord-018387-ci5wx26t	68	27	HSC	HSC	NNP
cord-018387-ci5wx26t	68	28	compartment	compartment	NN
cord-018387-ci5wx26t	68	29	and	and	CC
cord-018387-ci5wx26t	68	30	is	be	VBZ
cord-018387-ci5wx26t	68	31	believed	believe	VBN
cord-018387-ci5wx26t	68	32	to	to	TO
cord-018387-ci5wx26t	68	33	be	be	VB
cord-018387-ci5wx26t	68	34	an	an	DT
cord-018387-ci5wx26t	68	35	important	important	JJ
cord-018387-ci5wx26t	68	36	contributor	contributor	NN
cord-018387-ci5wx26t	68	37	to	to	IN
cord-018387-ci5wx26t	68	38	the	the	DT
cord-018387-ci5wx26t	68	39	decline	decline	NN
cord-018387-ci5wx26t	68	40	of	of	IN
cord-018387-ci5wx26t	68	41	immune	immune	JJ
cord-018387-ci5wx26t	68	42	competence	competence	NN
cord-018387-ci5wx26t	68	43	in	in	IN
cord-018387-ci5wx26t	68	44	the	the	DT
cord-018387-ci5wx26t	68	45	elderly	elderly	JJ
cord-018387-ci5wx26t	68	46	[	[	-LRB-
cord-018387-ci5wx26t	68	47	2	2	CD
cord-018387-ci5wx26t	68	48	,	,	,
cord-018387-ci5wx26t	68	49	37	37	CD
cord-018387-ci5wx26t	68	50	,	,	,
cord-018387-ci5wx26t	68	51	38	38	CD
cord-018387-ci5wx26t	68	52	]	]	-RRB-
cord-018387-ci5wx26t	68	53	.	.	.
cord-018387-ci5wx26t	69	1	Given	give	VBN
cord-018387-ci5wx26t	69	2	the	the	DT
cord-018387-ci5wx26t	69	3	age	age	NN
cord-018387-ci5wx26t	69	4	-	-	HYPH
cord-018387-ci5wx26t	69	5	associated	associate	VBN
cord-018387-ci5wx26t	69	6	alterations	alteration	NNS
cord-018387-ci5wx26t	69	7	at	at	IN
cord-018387-ci5wx26t	69	8	the	the	DT
cord-018387-ci5wx26t	69	9	level	level	NN
cord-018387-ci5wx26t	69	10	of	of	IN
cord-018387-ci5wx26t	69	11	immune	immune	JJ
cord-018387-ci5wx26t	69	12	cell	cell	NN
cord-018387-ci5wx26t	69	13	production	production	NN
cord-018387-ci5wx26t	69	14	in	in	IN
cord-018387-ci5wx26t	69	15	the	the	DT
cord-018387-ci5wx26t	69	16	bone	bone	NN
cord-018387-ci5wx26t	69	17	marrow	marrow	NN
cord-018387-ci5wx26t	69	18	and	and	CC
cord-018387-ci5wx26t	69	19	the	the	DT
cord-018387-ci5wx26t	69	20	skewing	skewing	NN
cord-018387-ci5wx26t	69	21	toward	toward	IN
cord-018387-ci5wx26t	69	22	myeloid	myeloid	JJ
cord-018387-ci5wx26t	69	23	differentiation	differentiation	NN
cord-018387-ci5wx26t	69	24	in	in	IN
cord-018387-ci5wx26t	69	25	the	the	DT
cord-018387-ci5wx26t	69	26	cells	cell	NNS
cord-018387-ci5wx26t	69	27	exported	export	VBN
cord-018387-ci5wx26t	69	28	to	to	IN
cord-018387-ci5wx26t	69	29	the	the	DT
cord-018387-ci5wx26t	69	30	periphery	periphery	NN
cord-018387-ci5wx26t	69	31	,	,	,
cord-018387-ci5wx26t	69	32	it	-PRON-	PRP
cord-018387-ci5wx26t	69	33	is	be	VBZ
cord-018387-ci5wx26t	69	34	not	not	RB
cord-018387-ci5wx26t	69	35	surprising	surprising	JJ
cord-018387-ci5wx26t	69	36	that	that	IN
cord-018387-ci5wx26t	69	37	immune	immune	JJ
cord-018387-ci5wx26t	69	38	functioning	functioning	NN
cord-018387-ci5wx26t	69	39	also	also	RB
cord-018387-ci5wx26t	69	40	changes	change	VBZ
cord-018387-ci5wx26t	69	41	with	with	IN
cord-018387-ci5wx26t	69	42	age	age	NN
cord-018387-ci5wx26t	69	43	.	.	.
cord-018387-ci5wx26t	70	1	Not	not	RB
cord-018387-ci5wx26t	70	2	only	only	RB
cord-018387-ci5wx26t	70	3	are	be	VBP
cord-018387-ci5wx26t	70	4	fewer	few	JJR
cord-018387-ci5wx26t	70	5	B	b	NN
cord-018387-ci5wx26t	70	6	cells	cell	NNS
cord-018387-ci5wx26t	70	7	produced	produce	VBN
cord-018387-ci5wx26t	70	8	and	and	CC
cord-018387-ci5wx26t	70	9	fewer	few	JJR
cord-018387-ci5wx26t	70	10	T	t	NN
cord-018387-ci5wx26t	70	11	-	-	HYPH
cord-018387-ci5wx26t	70	12	cell	cell	NN
cord-018387-ci5wx26t	70	13	progenitors	progenitor	NNS
cord-018387-ci5wx26t	70	14	,	,	,
cord-018387-ci5wx26t	70	15	but	but	CC
cord-018387-ci5wx26t	70	16	in	in	IN
cord-018387-ci5wx26t	70	17	the	the	DT
cord-018387-ci5wx26t	70	18	case	case	NN
cord-018387-ci5wx26t	70	19	of	of	IN
cord-018387-ci5wx26t	70	20	the	the	DT
cord-018387-ci5wx26t	70	21	latter	latter	JJ
cord-018387-ci5wx26t	70	22	,	,	,
cord-018387-ci5wx26t	70	23	their	-PRON-	PRP$
cord-018387-ci5wx26t	70	24	development	development	NN
cord-018387-ci5wx26t	70	25	in	in	IN
cord-018387-ci5wx26t	70	26	the	the	DT
cord-018387-ci5wx26t	70	27	thymus	thymus	NN
cord-018387-ci5wx26t	70	28	is	be	VBZ
cord-018387-ci5wx26t	70	29	compromised	compromise	VBN
cord-018387-ci5wx26t	70	30	by	by	IN
cord-018387-ci5wx26t	70	31	the	the	DT
cord-018387-ci5wx26t	70	32	universal	universal	JJ
cord-018387-ci5wx26t	70	33	process	process	NN
cord-018387-ci5wx26t	70	34	of	of	IN
cord-018387-ci5wx26t	70	35	thymic	thymic	JJ
cord-018387-ci5wx26t	70	36	involution	involution	NN
cord-018387-ci5wx26t	70	37	(	(	-LRB-
cord-018387-ci5wx26t	70	38	Fig	Fig	NNP
cord-018387-ci5wx26t	70	39	.	.	NNP
cord-018387-ci5wx26t	70	40	14.1	14.1	CD
cord-018387-ci5wx26t	70	41	)	)	-RRB-
cord-018387-ci5wx26t	70	42	.	.	.
cord-018387-ci5wx26t	71	1	Although	although	IN
cord-018387-ci5wx26t	71	2	this	this	DT
cord-018387-ci5wx26t	71	3	may	may	MD
cord-018387-ci5wx26t	71	4	be	be	VB
cord-018387-ci5wx26t	71	5	viewed	view	VBN
cord-018387-ci5wx26t	71	6	as	as	IN
cord-018387-ci5wx26t	71	7	a	a	DT
cord-018387-ci5wx26t	71	8	developmental	developmental	JJ
cord-018387-ci5wx26t	71	9	event	event	NN
cord-018387-ci5wx26t	71	10	and	and	CC
cord-018387-ci5wx26t	71	11	not	not	RB
cord-018387-ci5wx26t	71	12	truly	truly	RB
cord-018387-ci5wx26t	71	13	a	a	DT
cord-018387-ci5wx26t	71	14	senescence	senescence	NN
cord-018387-ci5wx26t	71	15	effect	effect	NN
cord-018387-ci5wx26t	71	16	,	,	,
cord-018387-ci5wx26t	71	17	it	-PRON-	PRP
cord-018387-ci5wx26t	71	18	is	be	VBZ
cord-018387-ci5wx26t	71	19	thought	think	VBN
cord-018387-ci5wx26t	71	20	to	to	TO
cord-018387-ci5wx26t	71	21	have	have	VB
cord-018387-ci5wx26t	71	22	dramatic	dramatic	JJ
cord-018387-ci5wx26t	71	23	consequences	consequence	NNS
cord-018387-ci5wx26t	71	24	for	for	IN
cord-018387-ci5wx26t	71	25	immunity	immunity	NN
cord-018387-ci5wx26t	71	26	over	over	IN
cord-018387-ci5wx26t	71	27	the	the	DT
cord-018387-ci5wx26t	71	28	lifespan	lifespan	NN
cord-018387-ci5wx26t	71	29	[	[	-LRB-
cord-018387-ci5wx26t	71	30	18	18	CD
cord-018387-ci5wx26t	71	31	]	]	-RRB-
cord-018387-ci5wx26t	71	32	.	.	.
cord-018387-ci5wx26t	72	1	Both	both	DT
cord-018387-ci5wx26t	72	2	extrinsic	extrinsic	JJ
cord-018387-ci5wx26t	72	3	and	and	CC
cord-018387-ci5wx26t	72	4	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	72	5	factors	factor	NNS
cord-018387-ci5wx26t	72	6	are	be	VBP
cord-018387-ci5wx26t	72	7	considered	consider	VBN
cord-018387-ci5wx26t	72	8	(	(	-LRB-
cord-018387-ci5wx26t	72	9	Fig	Fig	NNP
cord-018387-ci5wx26t	72	10	.	.	NNP
cord-018387-ci5wx26t	72	11	14.1	14.1	CD
cord-018387-ci5wx26t	72	12	)	)	-RRB-
cord-018387-ci5wx26t	72	13	to	to	TO
cord-018387-ci5wx26t	72	14	be	be	VB
cord-018387-ci5wx26t	72	15	involved	involve	VBN
cord-018387-ci5wx26t	72	16	in	in	IN
cord-018387-ci5wx26t	72	17	causing	cause	VBG
cord-018387-ci5wx26t	72	18	thymic	thymic	JJ
cord-018387-ci5wx26t	72	19	involution	involution	NN
cord-018387-ci5wx26t	72	20	,	,	,
cord-018387-ci5wx26t	72	21	including	include	VBG
cord-018387-ci5wx26t	72	22	the	the	DT
cord-018387-ci5wx26t	72	23	thymic	thymic	JJ
cord-018387-ci5wx26t	72	24	microenvironment	microenvironment	NN
cord-018387-ci5wx26t	72	25	as	as	RB
cord-018387-ci5wx26t	72	26	well	well	RB
cord-018387-ci5wx26t	72	27	as	as	IN
cord-018387-ci5wx26t	72	28	the	the	DT
cord-018387-ci5wx26t	72	29	impaired	impair	VBN
cord-018387-ci5wx26t	72	30	development	development	NN
cord-018387-ci5wx26t	72	31	of	of	IN
cord-018387-ci5wx26t	72	32	aged	aged	JJ
cord-018387-ci5wx26t	72	33	thymocytes	thymocyte	NNS
cord-018387-ci5wx26t	72	34	themselves	-PRON-	PRP
cord-018387-ci5wx26t	72	35	[	[	-LRB-
cord-018387-ci5wx26t	72	36	39	39	CD
cord-018387-ci5wx26t	72	37	]	]	-RRB-
cord-018387-ci5wx26t	72	38	.	.	.
cord-018387-ci5wx26t	73	1	During	during	IN
cord-018387-ci5wx26t	73	2	this	this	DT
cord-018387-ci5wx26t	73	3	ongoing	ongoing	JJ
cord-018387-ci5wx26t	73	4	process	process	NN
cord-018387-ci5wx26t	73	5	,	,	,
cord-018387-ci5wx26t	73	6	beginning	begin	VBG
cord-018387-ci5wx26t	73	7	even	even	RB
cord-018387-ci5wx26t	73	8	before	before	IN
cord-018387-ci5wx26t	73	9	puberty	puberty	NN
cord-018387-ci5wx26t	73	10	,	,	,
cord-018387-ci5wx26t	73	11	as	as	IN
cord-018387-ci5wx26t	73	12	in	in	IN
cord-018387-ci5wx26t	73	13	the	the	DT
cord-018387-ci5wx26t	73	14	bone	bone	NN
cord-018387-ci5wx26t	73	15	marrow	marrow	NN
cord-018387-ci5wx26t	73	16	,	,	,
cord-018387-ci5wx26t	73	17	a	a	DT
cord-018387-ci5wx26t	73	18	progressive	progressive	JJ
cord-018387-ci5wx26t	73	19	replacement	replacement	NN
cord-018387-ci5wx26t	73	20	of	of	IN
cord-018387-ci5wx26t	73	21	lymphoid	lymphoid	JJ
cord-018387-ci5wx26t	73	22	tissue	tissue	NN
cord-018387-ci5wx26t	73	23	by	by	IN
cord-018387-ci5wx26t	73	24	fatty	fatty	JJ
cord-018387-ci5wx26t	73	25	tissue	tissue	NN
cord-018387-ci5wx26t	73	26	takes	take	VBZ
cord-018387-ci5wx26t	73	27	place	place	NN
cord-018387-ci5wx26t	73	28	,	,	,
cord-018387-ci5wx26t	73	29	accompanied	accompany	VBN
cord-018387-ci5wx26t	73	30	by	by	IN
cord-018387-ci5wx26t	73	31	a	a	DT
cord-018387-ci5wx26t	73	32	reduction	reduction	NN
cord-018387-ci5wx26t	73	33	of	of	IN
cord-018387-ci5wx26t	73	34	the	the	DT
cord-018387-ci5wx26t	73	35	active	active	JJ
cord-018387-ci5wx26t	73	36	areas	area	NNS
cord-018387-ci5wx26t	73	37	of	of	IN
cord-018387-ci5wx26t	73	38	thymopoiesis	thymopoiesis	NN
cord-018387-ci5wx26t	73	39	[	[	-LRB-
cord-018387-ci5wx26t	73	40	40	40	CD
cord-018387-ci5wx26t	73	41	]	]	-RRB-
cord-018387-ci5wx26t	73	42	.	.	.
cord-018387-ci5wx26t	74	1	Most	Most	JJS
cord-018387-ci5wx26t	74	2	elderly	elderly	JJ
cord-018387-ci5wx26t	74	3	people	people	NNS
cord-018387-ci5wx26t	74	4	do	do	VBP
cord-018387-ci5wx26t	74	5	retain	retain	VB
cord-018387-ci5wx26t	74	6	some	some	DT
cord-018387-ci5wx26t	74	7	residual	residual	JJ
cord-018387-ci5wx26t	74	8	thymic	thymic	JJ
cord-018387-ci5wx26t	74	9	function	function	NN
cord-018387-ci5wx26t	74	10	,	,	,
cord-018387-ci5wx26t	74	11	which	which	WDT
cord-018387-ci5wx26t	74	12	may	may	MD
cord-018387-ci5wx26t	74	13	act	act	VB
cord-018387-ci5wx26t	74	14	to	to	TO
cord-018387-ci5wx26t	74	15	provide	provide	VB
cord-018387-ci5wx26t	74	16	a	a	DT
cord-018387-ci5wx26t	74	17	continuous	continuous	JJ
cord-018387-ci5wx26t	74	18	low	low	JJ
cord-018387-ci5wx26t	74	19	-	-	HYPH
cord-018387-ci5wx26t	74	20	level	level	NN
cord-018387-ci5wx26t	74	21	input	input	NN
cord-018387-ci5wx26t	74	22	of	of	IN
cord-018387-ci5wx26t	74	23	new	new	JJ
cord-018387-ci5wx26t	74	24	naïve	naïve	JJ
cord-018387-ci5wx26t	74	25	T	t	NN
cord-018387-ci5wx26t	74	26	cells	cell	NNS
cord-018387-ci5wx26t	74	27	(	(	-LRB-
cord-018387-ci5wx26t	74	28	Fig	Fig	NNP
cord-018387-ci5wx26t	74	29	.	.	NNP
cord-018387-ci5wx26t	74	30	14.1	14.1	CD
cord-018387-ci5wx26t	74	31	)	)	-RRB-
cord-018387-ci5wx26t	74	32	to	to	IN
cord-018387-ci5wx26t	74	33	the	the	DT
cord-018387-ci5wx26t	74	34	periphery	periphery	NN
cord-018387-ci5wx26t	74	35	[	[	-LRB-
cord-018387-ci5wx26t	74	36	41	41	CD
cord-018387-ci5wx26t	74	37	]	]	-RRB-
cord-018387-ci5wx26t	74	38	at	at	IN
cord-018387-ci5wx26t	74	39	least	least	JJS
cord-018387-ci5wx26t	74	40	until	until	IN
cord-018387-ci5wx26t	74	41	extreme	extreme	JJ
cord-018387-ci5wx26t	74	42	old	old	JJ
cord-018387-ci5wx26t	74	43	age	age	NN
cord-018387-ci5wx26t	74	44	[	[	-LRB-
cord-018387-ci5wx26t	74	45	18	18	CD
cord-018387-ci5wx26t	74	46	]	]	-RRB-
cord-018387-ci5wx26t	74	47	.	.	.
cord-018387-ci5wx26t	75	1	The	the	DT
cord-018387-ci5wx26t	75	2	end	end	NN
cord-018387-ci5wx26t	75	3	result	result	NN
cord-018387-ci5wx26t	75	4	of	of	IN
cord-018387-ci5wx26t	75	5	thymic	thymic	JJ
cord-018387-ci5wx26t	75	6	involution	involution	NN
cord-018387-ci5wx26t	75	7	is	be	VBZ
cord-018387-ci5wx26t	75	8	that	that	IN
cord-018387-ci5wx26t	75	9	the	the	DT
cord-018387-ci5wx26t	75	10	individual	individual	NN
cord-018387-ci5wx26t	75	11	is	be	VBZ
cord-018387-ci5wx26t	75	12	equipped	equip	VBN
cord-018387-ci5wx26t	75	13	with	with	IN
cord-018387-ci5wx26t	75	14	a	a	DT
cord-018387-ci5wx26t	75	15	set	set	NN
cord-018387-ci5wx26t	75	16	of	of	IN
cord-018387-ci5wx26t	75	17	naïve	naïve	JJ
cord-018387-ci5wx26t	75	18	T	t	NN
cord-018387-ci5wx26t	75	19	cells	cell	NNS
cord-018387-ci5wx26t	75	20	early	early	RB
cord-018387-ci5wx26t	75	21	in	in	IN
cord-018387-ci5wx26t	75	22	life	life	NN
cord-018387-ci5wx26t	75	23	,	,	,
cord-018387-ci5wx26t	75	24	but	but	CC
cord-018387-ci5wx26t	75	25	which	which	WDT
cord-018387-ci5wx26t	75	26	are	be	VBP
cord-018387-ci5wx26t	75	27	not	not	RB
cord-018387-ci5wx26t	75	28	constantly	constantly	RB
cord-018387-ci5wx26t	75	29	replaced	replace	VBN
cord-018387-ci5wx26t	75	30	at	at	IN
cord-018387-ci5wx26t	75	31	the	the	DT
cord-018387-ci5wx26t	75	32	same	same	JJ
cord-018387-ci5wx26t	75	33	level	level	NN
cord-018387-ci5wx26t	75	34	throughout	throughout	IN
cord-018387-ci5wx26t	75	35	life	life	NN
cord-018387-ci5wx26t	75	36	.	.	.
cord-018387-ci5wx26t	76	1	Thus	thus	RB
cord-018387-ci5wx26t	76	2	,	,	,
cord-018387-ci5wx26t	76	3	elderly	elderly	JJ
cord-018387-ci5wx26t	76	4	people	people	NNS
cord-018387-ci5wx26t	76	5	have	have	VBP
cord-018387-ci5wx26t	76	6	vanishingly	vanishingly	RB
cord-018387-ci5wx26t	76	7	small	small	JJ
cord-018387-ci5wx26t	76	8	numbers	number	NNS
cord-018387-ci5wx26t	76	9	of	of	IN
cord-018387-ci5wx26t	76	10	naïve	naïve	JJ
cord-018387-ci5wx26t	76	11	T	t	NN
cord-018387-ci5wx26t	76	12	cells	cell	NNS
cord-018387-ci5wx26t	76	13	and	and	CC
cord-018387-ci5wx26t	76	14	accumulations	accumulation	NNS
cord-018387-ci5wx26t	76	15	of	of	IN
cord-018387-ci5wx26t	76	16	memory	memory	NN
cord-018387-ci5wx26t	76	17	T	t	NN
cord-018387-ci5wx26t	76	18	cells	cell	NNS
cord-018387-ci5wx26t	76	19	(	(	-LRB-
cord-018387-ci5wx26t	76	20	Figs	fig	NNS
cord-018387-ci5wx26t	76	21	.	.	.
cord-018387-ci5wx26t	77	1	14.1	14.1	CD
cord-018387-ci5wx26t	77	2	and	and	CC
cord-018387-ci5wx26t	77	3	14.2	14.2	CD
cord-018387-ci5wx26t	77	4	)	)	-RRB-
cord-018387-ci5wx26t	77	5	,	,	,
cord-018387-ci5wx26t	77	6	mostly	mostly	RB
cord-018387-ci5wx26t	77	7	specific	specific	JJ
cord-018387-ci5wx26t	77	8	for	for	IN
cord-018387-ci5wx26t	77	9	the	the	DT
cord-018387-ci5wx26t	77	10	pathogens	pathogen	NNS
cord-018387-ci5wx26t	77	11	that	that	WDT
cord-018387-ci5wx26t	77	12	they	-PRON-	PRP
cord-018387-ci5wx26t	77	13	have	have	VBP
cord-018387-ci5wx26t	77	14	previously	previously	RB
cord-018387-ci5wx26t	77	15	encountered	encounter	VBN
cord-018387-ci5wx26t	77	16	[	[	-LRB-
cord-018387-ci5wx26t	77	17	18	18	CD
cord-018387-ci5wx26t	77	18	]	]	-RRB-
cord-018387-ci5wx26t	77	19	.	.	.
cord-018387-ci5wx26t	78	1	Aged	aged	JJ
cord-018387-ci5wx26t	78	2	individuals	individual	NNS
cord-018387-ci5wx26t	78	3	have	have	VBP
cord-018387-ci5wx26t	78	4	decreased	decrease	VBN
cord-018387-ci5wx26t	78	5	protection	protection	NN
cord-018387-ci5wx26t	78	6	against	against	IN
cord-018387-ci5wx26t	78	7	newly	newly	RB
cord-018387-ci5wx26t	78	8	arising	arise	VBG
cord-018387-ci5wx26t	78	9	infections	infection	NNS
cord-018387-ci5wx26t	78	10	as	as	RB
cord-018387-ci5wx26t	78	11	well	well	RB
cord-018387-ci5wx26t	78	12	as	as	IN
cord-018387-ci5wx26t	78	13	difficulties	difficulty	NNS
cord-018387-ci5wx26t	78	14	in	in	IN
cord-018387-ci5wx26t	78	15	controlling	control	VBG
cord-018387-ci5wx26t	78	16	endogenous	endogenous	JJ
cord-018387-ci5wx26t	78	17	persistent	persistent	JJ
cord-018387-ci5wx26t	78	18	viral	viral	JJ
cord-018387-ci5wx26t	78	19	infections	infection	NNS
cord-018387-ci5wx26t	78	20	[	[	-LRB-
cord-018387-ci5wx26t	78	21	42	42	CD
cord-018387-ci5wx26t	78	22	]	]	-RRB-
cord-018387-ci5wx26t	78	23	.	.	.
cord-018387-ci5wx26t	79	1	According	accord	VBG
cord-018387-ci5wx26t	79	2	to	to	IN
cord-018387-ci5wx26t	79	3	a	a	DT
cord-018387-ci5wx26t	79	4	current	current	JJ
cord-018387-ci5wx26t	79	5	paradigm	paradigm	NN
cord-018387-ci5wx26t	79	6	,	,	,
cord-018387-ci5wx26t	79	7	the	the	DT
cord-018387-ci5wx26t	79	8	age	age	NN
cord-018387-ci5wx26t	79	9	-	-	HYPH
cord-018387-ci5wx26t	79	10	associated	associate	VBN
cord-018387-ci5wx26t	79	11	shrinkage	shrinkage	NN
cord-018387-ci5wx26t	79	12	of	of	IN
cord-018387-ci5wx26t	79	13	compartment	compartment	NN
cord-018387-ci5wx26t	79	14	size	size	NN
cord-018387-ci5wx26t	79	15	and	and	CC
cord-018387-ci5wx26t	79	16	diminution	diminution	NN
cord-018387-ci5wx26t	79	17	in	in	IN
cord-018387-ci5wx26t	79	18	T	T	NNP
cord-018387-ci5wx26t	79	19	-	-	HYPH
cord-018387-ci5wx26t	79	20	and	and	CC
cord-018387-ci5wx26t	79	21	B	b	NN
cord-018387-ci5wx26t	79	22	-	-	HYPH
cord-018387-ci5wx26t	79	23	cell	cell	NN
cord-018387-ci5wx26t	79	24	receptor	receptor	NN
cord-018387-ci5wx26t	79	25	diversity	diversity	NN
cord-018387-ci5wx26t	79	26	(	(	-LRB-
cord-018387-ci5wx26t	79	27	Fig	Fig	NNP
cord-018387-ci5wx26t	79	28	.	.	.
cord-018387-ci5wx26t	79	29	14	14	CD
cord-018387-ci5wx26t	79	30	.1	.1	NFP
cord-018387-ci5wx26t	79	31	)	)	-RRB-
cord-018387-ci5wx26t	79	32	appears	appear	VBZ
cord-018387-ci5wx26t	79	33	to	to	TO
cord-018387-ci5wx26t	79	34	be	be	VB
cord-018387-ci5wx26t	79	35	responsible	responsible	JJ
cord-018387-ci5wx26t	79	36	for	for	IN
cord-018387-ci5wx26t	79	37	the	the	DT
cord-018387-ci5wx26t	79	38	impaired	impaired	JJ
cord-018387-ci5wx26t	79	39	protective	protective	JJ
cord-018387-ci5wx26t	79	40	ability	ability	NN
cord-018387-ci5wx26t	79	41	of	of	IN
cord-018387-ci5wx26t	79	42	the	the	DT
cord-018387-ci5wx26t	79	43	immune	immune	JJ
cord-018387-ci5wx26t	79	44	system	system	NN
cord-018387-ci5wx26t	79	45	to	to	TO
cord-018387-ci5wx26t	79	46	respond	respond	VB
cord-018387-ci5wx26t	79	47	to	to	IN
cord-018387-ci5wx26t	79	48	a	a	DT
cord-018387-ci5wx26t	79	49	universe	universe	NN
cord-018387-ci5wx26t	79	50	of	of	IN
cord-018387-ci5wx26t	79	51	antigens	antigen	NNS
cord-018387-ci5wx26t	79	52	[	[	-LRB-
cord-018387-ci5wx26t	79	53	25	25	CD
cord-018387-ci5wx26t	79	54	,	,	,
cord-018387-ci5wx26t	79	55	26	26	CD
cord-018387-ci5wx26t	79	56	,	,	,
cord-018387-ci5wx26t	79	57	42	42	CD
cord-018387-ci5wx26t	79	58	]	]	-RRB-
cord-018387-ci5wx26t	79	59	.	.	.
cord-018387-ci5wx26t	80	1	Particularly	particularly	RB
cord-018387-ci5wx26t	80	2	,	,	,
cord-018387-ci5wx26t	80	3	dramatic	dramatic	JJ
cord-018387-ci5wx26t	80	4	changes	change	NNS
cord-018387-ci5wx26t	80	5	with	with	IN
cord-018387-ci5wx26t	80	6	age	age	NN
cord-018387-ci5wx26t	80	7	are	be	VBP
cord-018387-ci5wx26t	80	8	seen	see	VBN
cord-018387-ci5wx26t	80	9	in	in	IN
cord-018387-ci5wx26t	80	10	the	the	DT
cord-018387-ci5wx26t	80	11	repertoire	repertoire	NN
cord-018387-ci5wx26t	80	12	diversity	diversity	NN
cord-018387-ci5wx26t	80	13	that	that	WDT
cord-018387-ci5wx26t	80	14	declines	decline	VBZ
cord-018387-ci5wx26t	80	15	dramatically	dramatically	RB
cord-018387-ci5wx26t	80	16	[	[	-LRB-
cord-018387-ci5wx26t	80	17	29	29	CD
cord-018387-ci5wx26t	80	18	,	,	,
cord-018387-ci5wx26t	80	19	31	31	CD
cord-018387-ci5wx26t	80	20	]	]	-RRB-
cord-018387-ci5wx26t	80	21	.	.	.
cord-018387-ci5wx26t	81	1	Lifelong	lifelong	JJ
cord-018387-ci5wx26t	81	2	exposure	exposure	NN
cord-018387-ci5wx26t	81	3	to	to	IN
cord-018387-ci5wx26t	81	4	different	different	JJ
cord-018387-ci5wx26t	81	5	pathogens	pathogen	NNS
cord-018387-ci5wx26t	81	6	(	(	-LRB-
cord-018387-ci5wx26t	81	7	Figs	fig	NNS
cord-018387-ci5wx26t	81	8	.	.	.
cord-018387-ci5wx26t	81	9	14.1	14.1	CD
cord-018387-ci5wx26t	81	10	and	and	CC
cord-018387-ci5wx26t	81	11	14.2	14.2	CD
cord-018387-ci5wx26t	81	12	)	)	-RRB-
cord-018387-ci5wx26t	81	13	is	be	VBZ
cord-018387-ci5wx26t	81	14	regarded	regard	VBN
cord-018387-ci5wx26t	81	15	as	as	IN
cord-018387-ci5wx26t	81	16	a	a	DT
cord-018387-ci5wx26t	81	17	major	major	JJ
cord-018387-ci5wx26t	81	18	driving	driving	NN
cord-018387-ci5wx26t	81	19	factor	factor	NN
cord-018387-ci5wx26t	81	20	of	of	IN
cord-018387-ci5wx26t	81	21	the	the	DT
cord-018387-ci5wx26t	81	22	phenotypic	phenotypic	JJ
cord-018387-ci5wx26t	81	23	changes	change	NNS
cord-018387-ci5wx26t	81	24	in	in	IN
cord-018387-ci5wx26t	81	25	the	the	DT
cord-018387-ci5wx26t	81	26	distribution	distribution	NN
cord-018387-ci5wx26t	81	27	of	of	IN
cord-018387-ci5wx26t	81	28	T	t	NN
cord-018387-ci5wx26t	81	29	-	-	HYPH
cord-018387-ci5wx26t	81	30	cell	cell	NN
cord-018387-ci5wx26t	81	31	subsets	subset	NNS
cord-018387-ci5wx26t	81	32	over	over	IN
cord-018387-ci5wx26t	81	33	the	the	DT
cord-018387-ci5wx26t	81	34	life	life	NN
cord-018387-ci5wx26t	81	35	course	course	NN
cord-018387-ci5wx26t	81	36	.	.	.
cord-018387-ci5wx26t	82	1	For	for	IN
cord-018387-ci5wx26t	82	2	unclear	unclear	JJ
cord-018387-ci5wx26t	82	3	reasons	reason	NNS
cord-018387-ci5wx26t	82	4	,	,	,
cord-018387-ci5wx26t	82	5	especially	especially	RB
cord-018387-ci5wx26t	82	6	a	a	DT
cord-018387-ci5wx26t	82	7	latent	latent	JJ
cord-018387-ci5wx26t	82	8	infection	infection	NN
cord-018387-ci5wx26t	82	9	with	with	IN
cord-018387-ci5wx26t	82	10	cytomegalovirus	cytomegalovirus	NNP
cord-018387-ci5wx26t	82	11	(	(	-LRB-
cord-018387-ci5wx26t	82	12	CMV	CMV	NNP
cord-018387-ci5wx26t	82	13	)	)	-RRB-
cord-018387-ci5wx26t	82	14	,	,	,
cord-018387-ci5wx26t	82	15	but	but	CC
cord-018387-ci5wx26t	82	16	not	not	RB
cord-018387-ci5wx26t	82	17	with	with	IN
cord-018387-ci5wx26t	82	18	any	any	DT
cord-018387-ci5wx26t	82	19	other	other	JJ
cord-018387-ci5wx26t	82	20	herpes	herpes	NN
cord-018387-ci5wx26t	82	21	viruses	virus	NNS
cord-018387-ci5wx26t	82	22	,	,	,
cord-018387-ci5wx26t	82	23	with	with	IN
cord-018387-ci5wx26t	82	24	recurrent	recurrent	JJ
cord-018387-ci5wx26t	82	25	episodes	episode	NNS
cord-018387-ci5wx26t	82	26	of	of	IN
cord-018387-ci5wx26t	82	27	reactivation	reactivation	NN
cord-018387-ci5wx26t	82	28	has	have	VBZ
cord-018387-ci5wx26t	82	29	been	be	VBN
cord-018387-ci5wx26t	82	30	found	find	VBN
cord-018387-ci5wx26t	82	31	to	to	TO
cord-018387-ci5wx26t	82	32	promote	promote	VB
cord-018387-ci5wx26t	82	33	memory	memory	NN
cord-018387-ci5wx26t	82	34	T	t	NN
cord-018387-ci5wx26t	82	35	-	-	HYPH
cord-018387-ci5wx26t	82	36	cell	cell	NN
cord-018387-ci5wx26t	82	37	"	"	''
cord-018387-ci5wx26t	82	38	inflation	inflation	NN
cord-018387-ci5wx26t	82	39	"	"	''
cord-018387-ci5wx26t	82	40	and	and	CC
cord-018387-ci5wx26t	82	41	drive	drive	VB
cord-018387-ci5wx26t	82	42	T	t	NN
cord-018387-ci5wx26t	82	43	cells	cell	NNS
cord-018387-ci5wx26t	82	44	to	to	IN
cord-018387-ci5wx26t	82	45	a	a	DT
cord-018387-ci5wx26t	82	46	late	late	JJ
cord-018387-ci5wx26t	82	47	stage	stage	NN
cord-018387-ci5wx26t	82	48	of	of	IN
cord-018387-ci5wx26t	82	49	differentiation	differentiation	NN
cord-018387-ci5wx26t	82	50	.	.	.
cord-018387-ci5wx26t	83	1	In	in	IN
cord-018387-ci5wx26t	83	2	aged	aged	JJ
cord-018387-ci5wx26t	83	3	individuals	individual	NNS
cord-018387-ci5wx26t	83	4	,	,	,
cord-018387-ci5wx26t	83	5	oligoclonally	oligoclonally	RB
cord-018387-ci5wx26t	83	6	expanded	expand	VBD
cord-018387-ci5wx26t	83	7	CD8	CD8	NNP
cord-018387-ci5wx26t	83	8	+	+	CC
cord-018387-ci5wx26t	83	9	T	T	NNP
cord-018387-ci5wx26t	83	10	cells	cell	NNS
cord-018387-ci5wx26t	83	11	show	show	VBP
cord-018387-ci5wx26t	83	12	an	an	DT
cord-018387-ci5wx26t	83	13	increased	increase	VBN
cord-018387-ci5wx26t	83	14	expression	expression	NN
cord-018387-ci5wx26t	83	15	of	of	IN
cord-018387-ci5wx26t	83	16	late	late	JJ
cord-018387-ci5wx26t	83	17	-	-	HYPH
cord-018387-ci5wx26t	83	18	stage	stage	NN
cord-018387-ci5wx26t	83	19	differentiation	differentiation	NN
cord-018387-ci5wx26t	83	20	markers	marker	NNS
cord-018387-ci5wx26t	83	21	.	.	.
cord-018387-ci5wx26t	84	1	The	the	DT
cord-018387-ci5wx26t	84	2	accumulation	accumulation	NN
cord-018387-ci5wx26t	84	3	of	of	IN
cord-018387-ci5wx26t	84	4	these	these	DT
cord-018387-ci5wx26t	84	5	highly	highly	RB
cord-018387-ci5wx26t	84	6	differentiated	differentiate	VBN
cord-018387-ci5wx26t	84	7	T	t	NN
cord-018387-ci5wx26t	84	8	cells	cell	NNS
cord-018387-ci5wx26t	84	9	,	,	,
cord-018387-ci5wx26t	84	10	at	at	IN
cord-018387-ci5wx26t	84	11	least	least	JJS
cord-018387-ci5wx26t	84	12	some	some	DT
cord-018387-ci5wx26t	84	13	of	of	IN
cord-018387-ci5wx26t	84	14	which	which	WDT
cord-018387-ci5wx26t	84	15	may	may	MD
cord-018387-ci5wx26t	84	16	be	be	VB
cord-018387-ci5wx26t	84	17	truly	truly	RB
cord-018387-ci5wx26t	84	18	senescent	senescent	JJ
cord-018387-ci5wx26t	84	19	,	,	,
cord-018387-ci5wx26t	84	20	contributes	contribute	VBZ
cord-018387-ci5wx26t	84	21	to	to	IN
cord-018387-ci5wx26t	84	22	the	the	DT
cord-018387-ci5wx26t	84	23	age	age	NN
cord-018387-ci5wx26t	84	24	-	-	HYPH
cord-018387-ci5wx26t	84	25	associated	associate	VBN
cord-018387-ci5wx26t	84	26	increased	increase	VBN
cord-018387-ci5wx26t	84	27	production	production	NN
cord-018387-ci5wx26t	84	28	of	of	IN
cord-018387-ci5wx26t	84	29	pro	pro	JJ
cord-018387-ci5wx26t	84	30	-	-	JJ
cord-018387-ci5wx26t	84	31	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	84	32	cytokines	cytokine	NNS
cord-018387-ci5wx26t	84	33	and	and	CC
cord-018387-ci5wx26t	84	34	low	low	JJ
cord-018387-ci5wx26t	84	35	-	-	HYPH
cord-018387-ci5wx26t	84	36	grade	grade	NN
cord-018387-ci5wx26t	84	37	inflammation	inflammation	NN
cord-018387-ci5wx26t	84	38	and	and	CC
cord-018387-ci5wx26t	84	39	could	could	MD
cord-018387-ci5wx26t	84	40	thus	thus	RB
cord-018387-ci5wx26t	84	41	possibly	possibly	RB
cord-018387-ci5wx26t	84	42	also	also	RB
cord-018387-ci5wx26t	84	43	contribute	contribute	VB
cord-018387-ci5wx26t	84	44	to	to	IN
cord-018387-ci5wx26t	84	45	age	age	NN
cord-018387-ci5wx26t	84	46	-	-	HYPH
cord-018387-ci5wx26t	84	47	related	relate	VBN
cord-018387-ci5wx26t	84	48	morbidity	morbidity	NN
cord-018387-ci5wx26t	84	49	and	and	CC
cord-018387-ci5wx26t	84	50	mortality	mortality	NN
cord-018387-ci5wx26t	84	51	[	[	-LRB-
cord-018387-ci5wx26t	84	52	24	24	CD
cord-018387-ci5wx26t	84	53	,	,	,
cord-018387-ci5wx26t	84	54	[	[	-LRB-
cord-018387-ci5wx26t	84	55	43	43	CD
cord-018387-ci5wx26t	84	56	]	]	-RRB-
cord-018387-ci5wx26t	84	57	[	[	-LRB-
cord-018387-ci5wx26t	84	58	44	44	CD
cord-018387-ci5wx26t	84	59	]	]	-RRB-
cord-018387-ci5wx26t	84	60	[	[	-LRB-
cord-018387-ci5wx26t	84	61	45	45	CD
cord-018387-ci5wx26t	84	62	]	]	-RRB-
cord-018387-ci5wx26t	85	1	[	[	-LRB-
cord-018387-ci5wx26t	85	2	46	46	CD
cord-018387-ci5wx26t	85	3	]	]	-RRB-
cord-018387-ci5wx26t	85	4	[	[	-LRB-
cord-018387-ci5wx26t	85	5	47	47	CD
cord-018387-ci5wx26t	85	6	]	]	-RRB-
cord-018387-ci5wx26t	85	7	.	.	.
cord-018387-ci5wx26t	86	1	Regulatory	regulatory	JJ
cord-018387-ci5wx26t	86	2	T	t	NN
cord-018387-ci5wx26t	86	3	cells	cell	NNS
cord-018387-ci5wx26t	86	4	(	(	-LRB-
cord-018387-ci5wx26t	86	5	Tregs	Tregs	NNP
cord-018387-ci5wx26t	86	6	)	)	-RRB-
cord-018387-ci5wx26t	86	7	play	play	VB
cord-018387-ci5wx26t	86	8	a	a	DT
cord-018387-ci5wx26t	86	9	central	central	JJ
cord-018387-ci5wx26t	86	10	role	role	NN
cord-018387-ci5wx26t	86	11	in	in	IN
cord-018387-ci5wx26t	86	12	immune	immune	JJ
cord-018387-ci5wx26t	86	13	regulation	regulation	NN
cord-018387-ci5wx26t	87	1	(	(	-LRB-
cord-018387-ci5wx26t	87	2	Fig	Fig	NNP
cord-018387-ci5wx26t	87	3	.	.	.
cord-018387-ci5wx26t	88	1	14	14	CD
cord-018387-ci5wx26t	88	2	.	.	.
cord-018387-ci5wx26t	88	3	1	1	LS
cord-018387-ci5wx26t	88	4	)	)	-RRB-
cord-018387-ci5wx26t	88	5	,	,	,
cord-018387-ci5wx26t	88	6	providing	provide	VBG
cord-018387-ci5wx26t	88	7	a	a	DT
cord-018387-ci5wx26t	88	8	delicate	delicate	JJ
cord-018387-ci5wx26t	88	9	balance	balance	NN
cord-018387-ci5wx26t	88	10	between	between	IN
cord-018387-ci5wx26t	88	11	protective	protective	JJ
cord-018387-ci5wx26t	88	12	and	and	CC
cord-018387-ci5wx26t	88	13	patho-	patho-	NN
cord-018387-ci5wx26t	89	1	The	the	DT
cord-018387-ci5wx26t	89	2	aging	age	VBG
cord-018387-ci5wx26t	89	3	immune	immune	JJ
cord-018387-ci5wx26t	89	4	system	system	NN
cord-018387-ci5wx26t	89	5	.	.	.
cord-018387-ci5wx26t	90	1	The	the	DT
cord-018387-ci5wx26t	90	2	HSC	HSC	NNP
cord-018387-ci5wx26t	90	3	compartment	compartment	NN
cord-018387-ci5wx26t	90	4	is	be	VBZ
cord-018387-ci5wx26t	90	5	negatively	negatively	RB
cord-018387-ci5wx26t	90	6	modulated	modulate	VBN
cord-018387-ci5wx26t	90	7	and	and	CC
cord-018387-ci5wx26t	90	8	functionally	functionally	RB
cord-018387-ci5wx26t	90	9	affected	affect	VBN
cord-018387-ci5wx26t	90	10	by	by	IN
cord-018387-ci5wx26t	90	11	aging	age	VBG
cord-018387-ci5wx26t	90	12	(	(	-LRB-
cord-018387-ci5wx26t	90	13	a	a	NN
cord-018387-ci5wx26t	90	14	)	)	-RRB-
cord-018387-ci5wx26t	90	15	.	.	.
cord-018387-ci5wx26t	91	1	Age	age	NN
cord-018387-ci5wx26t	91	2	-	-	HYPH
cord-018387-ci5wx26t	91	3	related	relate	VBN
cord-018387-ci5wx26t	91	4	modification	modification	NN
cord-018387-ci5wx26t	91	5	within	within	IN
cord-018387-ci5wx26t	91	6	the	the	DT
cord-018387-ci5wx26t	91	7	HSC	HSC	NNP
cord-018387-ci5wx26t	91	8	compartment	compartment	NN
cord-018387-ci5wx26t	91	9	may	may	MD
cord-018387-ci5wx26t	91	10	be	be	VB
cord-018387-ci5wx26t	91	11	partly	partly	RB
cord-018387-ci5wx26t	91	12	due	due	JJ
cord-018387-ci5wx26t	91	13	to	to	IN
cord-018387-ci5wx26t	91	14	"	"	``
cord-018387-ci5wx26t	91	15	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	91	16	cellular	cellular	JJ
cord-018387-ci5wx26t	91	17	aging	aging	NN
cord-018387-ci5wx26t	91	18	"	"	''
cord-018387-ci5wx26t	91	19	of	of	IN
cord-018387-ci5wx26t	91	20	HSCs	hsc	NNS
cord-018387-ci5wx26t	91	21	themselves	-PRON-	PRP
cord-018387-ci5wx26t	91	22	,	,	,
cord-018387-ci5wx26t	91	23	with	with	IN
cord-018387-ci5wx26t	91	24	accumulated	accumulate	VBN
cord-018387-ci5wx26t	91	25	DNA	dna	NN
cord-018387-ci5wx26t	91	26	damage	damage	NN
cord-018387-ci5wx26t	91	27	,	,	,
cord-018387-ci5wx26t	91	28	telomere	telomere	NN
cord-018387-ci5wx26t	91	29	attrition	attrition	NN
cord-018387-ci5wx26t	91	30	,	,	,
cord-018387-ci5wx26t	91	31	and	and	CC
cord-018387-ci5wx26t	91	32	epigenetic	epigenetic	JJ
cord-018387-ci5wx26t	91	33	deregulation	deregulation	NN
cord-018387-ci5wx26t	91	34	.	.	.
cord-018387-ci5wx26t	92	1	The	the	DT
cord-018387-ci5wx26t	92	2	extracellular	extracellular	JJ
cord-018387-ci5wx26t	92	3	and	and	CC
cord-018387-ci5wx26t	92	4	stromal	stromal	JJ
cord-018387-ci5wx26t	92	5	matrix	matrix	NN
cord-018387-ci5wx26t	92	6	also	also	RB
cord-018387-ci5wx26t	92	7	undergoes	undergo	VBZ
cord-018387-ci5wx26t	92	8	dramatic	dramatic	JJ
cord-018387-ci5wx26t	92	9	structural	structural	JJ
cord-018387-ci5wx26t	92	10	changes	change	NNS
cord-018387-ci5wx26t	92	11	in	in	IN
cord-018387-ci5wx26t	92	12	terms	term	NNS
cord-018387-ci5wx26t	92	13	of	of	IN
cord-018387-ci5wx26t	92	14	the	the	DT
cord-018387-ci5wx26t	92	15	numbers	number	NNS
cord-018387-ci5wx26t	92	16	of	of	IN
cord-018387-ci5wx26t	92	17	stromal	stromal	JJ
cord-018387-ci5wx26t	92	18	cells	cell	NNS
cord-018387-ci5wx26t	92	19	and	and	CC
cord-018387-ci5wx26t	92	20	osteoblasts	osteoblast	NNS
cord-018387-ci5wx26t	92	21	and	and	CC
cord-018387-ci5wx26t	92	22	the	the	DT
cord-018387-ci5wx26t	92	23	reduced	reduce	VBN
cord-018387-ci5wx26t	92	24	production	production	NN
cord-018387-ci5wx26t	92	25	of	of	IN
cord-018387-ci5wx26t	92	26	IL-7	IL-7	NNP
cord-018387-ci5wx26t	92	27	.	.	.
cord-018387-ci5wx26t	93	1	The	the	DT
cord-018387-ci5wx26t	93	2	aged	aged	JJ
cord-018387-ci5wx26t	93	3	pool	pool	NN
cord-018387-ci5wx26t	93	4	of	of	IN
cord-018387-ci5wx26t	93	5	HSC	HSC	NNP
cord-018387-ci5wx26t	93	6	shows	show	VBZ
cord-018387-ci5wx26t	93	7	a	a	DT
cord-018387-ci5wx26t	93	8	marked	marked	JJ
cord-018387-ci5wx26t	93	9	shift	shift	NN
cord-018387-ci5wx26t	93	10	in	in	IN
cord-018387-ci5wx26t	93	11	lymphoid	lymphoid	JJ
cord-018387-ci5wx26t	93	12	and	and	CC
cord-018387-ci5wx26t	93	13	myeloid	myeloid	JJ
cord-018387-ci5wx26t	93	14	lineage	lineage	NN
cord-018387-ci5wx26t	93	15	output	output	NN
cord-018387-ci5wx26t	93	16	.	.	.
cord-018387-ci5wx26t	94	1	Thymic	thymic	JJ
cord-018387-ci5wx26t	94	2	involution	involution	NN
cord-018387-ci5wx26t	94	3	(	(	-LRB-
cord-018387-ci5wx26t	94	4	b	b	NN
cord-018387-ci5wx26t	94	5	)	)	-RRB-
cord-018387-ci5wx26t	94	6	involves	involve	VBZ
cord-018387-ci5wx26t	94	7	both	both	CC
cord-018387-ci5wx26t	94	8	extrinsic	extrinsic	JJ
cord-018387-ci5wx26t	94	9	and	and	CC
cord-018387-ci5wx26t	94	10	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	94	11	factors	factor	NNS
cord-018387-ci5wx26t	94	12	,	,	,
cord-018387-ci5wx26t	94	13	including	include	VBG
cord-018387-ci5wx26t	94	14	the	the	DT
cord-018387-ci5wx26t	94	15	thymic	thymic	JJ
cord-018387-ci5wx26t	94	16	microenvironment	microenvironment	NN
cord-018387-ci5wx26t	94	17	as	as	RB
cord-018387-ci5wx26t	94	18	well	well	RB
cord-018387-ci5wx26t	94	19	as	as	IN
cord-018387-ci5wx26t	94	20	the	the	DT
cord-018387-ci5wx26t	94	21	impaired	impair	VBN
cord-018387-ci5wx26t	94	22	development	development	NN
cord-018387-ci5wx26t	94	23	of	of	IN
cord-018387-ci5wx26t	94	24	aged	aged	JJ
cord-018387-ci5wx26t	94	25	thymocytes	thymocyte	NNS
cord-018387-ci5wx26t	94	26	themselves	-PRON-	PRP
cord-018387-ci5wx26t	94	27	.	.	.
cord-018387-ci5wx26t	95	1	A	a	DT
cord-018387-ci5wx26t	95	2	progressive	progressive	JJ
cord-018387-ci5wx26t	95	3	replacement	replacement	NN
cord-018387-ci5wx26t	95	4	of	of	IN
cord-018387-ci5wx26t	95	5	lymphoid	lymphoid	JJ
cord-018387-ci5wx26t	95	6	tissue	tissue	NN
cord-018387-ci5wx26t	95	7	by	by	IN
cord-018387-ci5wx26t	95	8	fatty	fatty	JJ
cord-018387-ci5wx26t	95	9	tissue	tissue	NN
cord-018387-ci5wx26t	95	10	takes	take	VBZ
cord-018387-ci5wx26t	95	11	place	place	NN
cord-018387-ci5wx26t	95	12	,	,	,
cord-018387-ci5wx26t	95	13	accompanied	accompany	VBN
cord-018387-ci5wx26t	95	14	by	by	IN
cord-018387-ci5wx26t	95	15	a	a	DT
cord-018387-ci5wx26t	95	16	reduction	reduction	NN
cord-018387-ci5wx26t	95	17	of	of	IN
cord-018387-ci5wx26t	95	18	the	the	DT
cord-018387-ci5wx26t	95	19	active	active	JJ
cord-018387-ci5wx26t	95	20	areas	area	NNS
cord-018387-ci5wx26t	95	21	of	of	IN
cord-018387-ci5wx26t	95	22	thymopoiesis	thymopoiesis	NN
cord-018387-ci5wx26t	95	23	.	.	.
cord-018387-ci5wx26t	96	1	The	the	DT
cord-018387-ci5wx26t	96	2	end	end	NN
cord-018387-ci5wx26t	96	3	result	result	NN
cord-018387-ci5wx26t	96	4	of	of	IN
cord-018387-ci5wx26t	96	5	thymic	thymic	JJ
cord-018387-ci5wx26t	96	6	involution	involution	NN
cord-018387-ci5wx26t	96	7	is	be	VBZ
cord-018387-ci5wx26t	96	8	vanishingly	vanishingly	RB
cord-018387-ci5wx26t	96	9	small	small	JJ
cord-018387-ci5wx26t	96	10	numbers	number	NNS
cord-018387-ci5wx26t	96	11	of	of	IN
cord-018387-ci5wx26t	96	12	naïve	naïve	JJ
cord-018387-ci5wx26t	96	13	TC	TC	NNP
cord-018387-ci5wx26t	96	14	and	and	CC
cord-018387-ci5wx26t	96	15	accumulations	accumulation	NNS
cord-018387-ci5wx26t	96	16	of	of	IN
cord-018387-ci5wx26t	96	17	memory	memory	NN
cord-018387-ci5wx26t	96	18	TC	TC	NNP
cord-018387-ci5wx26t	96	19	(	(	-LRB-
cord-018387-ci5wx26t	96	20	c	c	NN
cord-018387-ci5wx26t	96	21	)	)	-RRB-
cord-018387-ci5wx26t	96	22	,	,	,
cord-018387-ci5wx26t	96	23	mostly	mostly	RB
cord-018387-ci5wx26t	96	24	specific	specific	JJ
cord-018387-ci5wx26t	96	25	for	for	IN
cord-018387-ci5wx26t	96	26	the	the	DT
cord-018387-ci5wx26t	96	27	pathogens	pathogen	NNS
cord-018387-ci5wx26t	96	28	that	that	WDT
cord-018387-ci5wx26t	96	29	they	-PRON-	PRP
cord-018387-ci5wx26t	96	30	have	have	VBP
cord-018387-ci5wx26t	96	31	previously	previously	RB
cord-018387-ci5wx26t	96	32	encountered	encounter	VBN
cord-018387-ci5wx26t	96	33	.	.	.
cord-018387-ci5wx26t	97	1	Age	age	NN
cord-018387-ci5wx26t	97	2	-	-	HYPH
cord-018387-ci5wx26t	97	3	affected	affect	VBN
cord-018387-ci5wx26t	97	4	Tregs	Tregs	NNP
cord-018387-ci5wx26t	97	5	(	(	-LRB-
cord-018387-ci5wx26t	97	6	d	d	NN
cord-018387-ci5wx26t	97	7	)	)	-RRB-
cord-018387-ci5wx26t	97	8	can	can	MD
cord-018387-ci5wx26t	97	9	induce	induce	VB
cord-018387-ci5wx26t	97	10	chronic	chronic	JJ
cord-018387-ci5wx26t	97	11	inflammation	inflammation	NN
cord-018387-ci5wx26t	97	12	,	,	,
cord-018387-ci5wx26t	97	13	an	an	DT
cord-018387-ci5wx26t	97	14	increased	increase	VBN
cord-018387-ci5wx26t	97	15	risk	risk	NN
cord-018387-ci5wx26t	97	16	of	of	IN
cord-018387-ci5wx26t	97	17	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	97	18	,	,	,
cord-018387-ci5wx26t	97	19	but	but	CC
cord-018387-ci5wx26t	97	20	also	also	RB
cord-018387-ci5wx26t	97	21	be	be	VB
cord-018387-ci5wx26t	97	22	responsible	responsible	JJ
cord-018387-ci5wx26t	97	23	for	for	IN
cord-018387-ci5wx26t	97	24	diminished	diminished	JJ
cord-018387-ci5wx26t	97	25	immunity	immunity	NN
cord-018387-ci5wx26t	97	26	.	.	.
cord-018387-ci5wx26t	98	1	Elevated	elevated	JJ
cord-018387-ci5wx26t	98	2	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	98	3	immune	immune	JJ
cord-018387-ci5wx26t	98	4	mediators	mediator	NNS
cord-018387-ci5wx26t	98	5	,	,	,
cord-018387-ci5wx26t	98	6	SARS	SARS	NNP
cord-018387-ci5wx26t	98	7	(	(	-LRB-
cord-018387-ci5wx26t	98	8	e	e	NNP
cord-018387-ci5wx26t	98	9	)	)	-RRB-
cord-018387-ci5wx26t	98	10	,	,	,
cord-018387-ci5wx26t	98	11	are	be	VBP
cord-018387-ci5wx26t	98	12	responsible	responsible	JJ
cord-018387-ci5wx26t	98	13	for	for	IN
cord-018387-ci5wx26t	98	14	the	the	DT
cord-018387-ci5wx26t	98	15	activation	activation	NN
cord-018387-ci5wx26t	98	16	of	of	IN
cord-018387-ci5wx26t	98	17	self	self	NN
cord-018387-ci5wx26t	98	18	-	-	HYPH
cord-018387-ci5wx26t	98	19	reactive	reactive	JJ
cord-018387-ci5wx26t	98	20	memory	memory	NN
cord-018387-ci5wx26t	98	21	BC	BC	NNP
cord-018387-ci5wx26t	98	22	,	,	,
cord-018387-ci5wx26t	98	23	producing	produce	VBG
cord-018387-ci5wx26t	98	24	increased	increase	VBN
cord-018387-ci5wx26t	98	25	levels	level	NNS
cord-018387-ci5wx26t	98	26	of	of	IN
cord-018387-ci5wx26t	98	27	auto	auto	NN
cord-018387-ci5wx26t	98	28	-	-	HYPH
cord-018387-ci5wx26t	98	29	Ab	ab	NN
cord-018387-ci5wx26t	98	30	(	(	-LRB-
cord-018387-ci5wx26t	98	31	f	f	NNP
cord-018387-ci5wx26t	98	32	)	)	-RRB-
cord-018387-ci5wx26t	98	33	,	,	,
cord-018387-ci5wx26t	98	34	which	which	WDT
cord-018387-ci5wx26t	98	35	are	be	VBP
cord-018387-ci5wx26t	98	36	frequent	frequent	JJ
cord-018387-ci5wx26t	98	37	in	in	IN
cord-018387-ci5wx26t	98	38	aged	aged	JJ
cord-018387-ci5wx26t	98	39	individuals	individual	NNS
cord-018387-ci5wx26t	98	40	as	as	IN
cord-018387-ci5wx26t	98	41	a	a	DT
cord-018387-ci5wx26t	98	42	result	result	NN
cord-018387-ci5wx26t	98	43	of	of	IN
cord-018387-ci5wx26t	98	44	tissue	tissue	NN
cord-018387-ci5wx26t	98	45	damage	damage	NN
cord-018387-ci5wx26t	98	46	and	and	CC
cord-018387-ci5wx26t	98	47	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	98	48	.	.	.
cord-018387-ci5wx26t	99	1	Repetitive	repetitive	JJ
cord-018387-ci5wx26t	99	2	antigenic	antigenic	JJ
cord-018387-ci5wx26t	99	3	challenges	challenge	NNS
cord-018387-ci5wx26t	99	4	over	over	IN
cord-018387-ci5wx26t	99	5	the	the	DT
cord-018387-ci5wx26t	99	6	lifetime	lifetime	NN
cord-018387-ci5wx26t	99	7	(	(	-LRB-
cord-018387-ci5wx26t	99	8	g	g	NN
cord-018387-ci5wx26t	99	9	)	)	-RRB-
cord-018387-ci5wx26t	99	10	may	may	MD
cord-018387-ci5wx26t	99	11	stimulate	stimulate	VB
cord-018387-ci5wx26t	99	12	pro	pro	JJ
cord-018387-ci5wx26t	99	13	-	-	JJ
cord-018387-ci5wx26t	99	14	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	99	15	cytokines	cytokine	NNS
cord-018387-ci5wx26t	99	16	,	,	,
cord-018387-ci5wx26t	99	17	contributing	contribute	VBG
cord-018387-ci5wx26t	99	18	to	to	IN
cord-018387-ci5wx26t	99	19	the	the	DT
cord-018387-ci5wx26t	99	20	maintenance	maintenance	NN
cord-018387-ci5wx26t	99	21	of	of	IN
cord-018387-ci5wx26t	99	22	persistent	persistent	JJ
cord-018387-ci5wx26t	99	23	chronic	chronic	JJ
cord-018387-ci5wx26t	99	24	inflammation	inflammation	NN
cord-018387-ci5wx26t	99	25	.	.	.
cord-018387-ci5wx26t	100	1	Self	self	NN
cord-018387-ci5wx26t	100	2	-	-	HYPH
cord-018387-ci5wx26t	100	3	reactive	reactive	JJ
cord-018387-ci5wx26t	100	4	B	b	NN
cord-018387-ci5wx26t	100	5	and	and	CC
cord-018387-ci5wx26t	100	6	T	t	NN
cord-018387-ci5wx26t	100	7	cells	cell	NNS
cord-018387-ci5wx26t	100	8	(	(	-LRB-
cord-018387-ci5wx26t	100	9	h	h	NN
cord-018387-ci5wx26t	100	10	)	)	-RRB-
cord-018387-ci5wx26t	100	11	recognize	recognize	VB
cord-018387-ci5wx26t	100	12	a	a	DT
cord-018387-ci5wx26t	100	13	self	self	NN
cord-018387-ci5wx26t	100	14	-	-	HYPH
cord-018387-ci5wx26t	100	15	antigen	antigen	NN
cord-018387-ci5wx26t	100	16	and	and	CC
cord-018387-ci5wx26t	100	17	differentiate	differentiate	VB
cord-018387-ci5wx26t	100	18	into	into	IN
cord-018387-ci5wx26t	100	19	memory	memory	NN
cord-018387-ci5wx26t	100	20	and	and	CC
cord-018387-ci5wx26t	100	21	effector	effector	NN
cord-018387-ci5wx26t	100	22	cells	cell	NNS
cord-018387-ci5wx26t	100	23	due	due	JJ
cord-018387-ci5wx26t	100	24	to	to	IN
cord-018387-ci5wx26t	100	25	a	a	DT
cord-018387-ci5wx26t	100	26	breakdown	breakdown	NN
cord-018387-ci5wx26t	100	27	of	of	IN
cord-018387-ci5wx26t	100	28	the	the	DT
cord-018387-ci5wx26t	100	29	control	control	NN
cord-018387-ci5wx26t	100	30	of	of	IN
cord-018387-ci5wx26t	100	31	autoreactivity	autoreactivity	NN
cord-018387-ci5wx26t	100	32	.	.	.
cord-018387-ci5wx26t	101	1	Chronic	chronic	JJ
cord-018387-ci5wx26t	101	2	inflammation	inflammation	NN
cord-018387-ci5wx26t	101	3	additionally	additionally	RB
cord-018387-ci5wx26t	101	4	resulting	result	VBG
cord-018387-ci5wx26t	101	5	in	in	IN
cord-018387-ci5wx26t	101	6	tissue	tissue	NN
cord-018387-ci5wx26t	101	7	injury	injury	NN
cord-018387-ci5wx26t	101	8	and	and	CC
cord-018387-ci5wx26t	101	9	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	101	10	attracts	attract	VBZ
cord-018387-ci5wx26t	101	11	DCs	dc	NNS
cord-018387-ci5wx26t	101	12	,	,	,
cord-018387-ci5wx26t	101	13	which	which	WDT
cord-018387-ci5wx26t	101	14	in	in	IN
cord-018387-ci5wx26t	101	15	elderly	elderly	JJ
cord-018387-ci5wx26t	101	16	people	people	NNS
cord-018387-ci5wx26t	101	17	have	have	VBP
cord-018387-ci5wx26t	101	18	impaired	impair	VBN
cord-018387-ci5wx26t	101	19	the	the	DT
cord-018387-ci5wx26t	101	20	ability	ability	NN
cord-018387-ci5wx26t	101	21	to	to	TO
cord-018387-ci5wx26t	101	22	take	take	VB
cord-018387-ci5wx26t	101	23	up	up	RP
cord-018387-ci5wx26t	101	24	apoptotic	apoptotic	JJ
cord-018387-ci5wx26t	101	25	cells	cell	NNS
cord-018387-ci5wx26t	101	26	(	(	-LRB-
cord-018387-ci5wx26t	101	27	i	i	NN
cord-018387-ci5wx26t	101	28	)	)	-RRB-
cord-018387-ci5wx26t	101	29	.	.	.
cord-018387-ci5wx26t	102	1	Instead	instead	RB
cord-018387-ci5wx26t	102	2	,	,	,
cord-018387-ci5wx26t	102	3	they	-PRON-	PRP
cord-018387-ci5wx26t	102	4	induce	induce	VBP
cord-018387-ci5wx26t	102	5	a	a	DT
cord-018387-ci5wx26t	102	6	vicious	vicious	JJ
cord-018387-ci5wx26t	102	7	circle	circle	NN
cord-018387-ci5wx26t	102	8	with	with	IN
cord-018387-ci5wx26t	102	9	a	a	DT
cord-018387-ci5wx26t	102	10	further	further	JJ
cord-018387-ci5wx26t	102	11	pro	pro	JJ
cord-018387-ci5wx26t	102	12	-	-	JJ
cord-018387-ci5wx26t	102	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	102	14	response	response	NN
cord-018387-ci5wx26t	102	15	and	and	CC
cord-018387-ci5wx26t	102	16	increased	increase	VBN
cord-018387-ci5wx26t	102	17	reactivity	reactivity	NN
cord-018387-ci5wx26t	102	18	to	to	IN
cord-018387-ci5wx26t	102	19	self	self	NN
cord-018387-ci5wx26t	102	20	-	-	HYPH
cord-018387-ci5wx26t	102	21	DNA	dna	NN
cord-018387-ci5wx26t	102	22	,	,	,
cord-018387-ci5wx26t	102	23	which	which	WDT
cord-018387-ci5wx26t	102	24	may	may	MD
cord-018387-ci5wx26t	102	25	be	be	VB
cord-018387-ci5wx26t	102	26	more	more	RBR
cord-018387-ci5wx26t	102	27	immunogenic	immunogenic	JJ
cord-018387-ci5wx26t	102	28	in	in	IN
cord-018387-ci5wx26t	102	29	the	the	DT
cord-018387-ci5wx26t	102	30	elderly	elderly	JJ
cord-018387-ci5wx26t	102	31	.	.	.
cord-018387-ci5wx26t	103	1	Additionally	additionally	RB
cord-018387-ci5wx26t	103	2	,	,	,
cord-018387-ci5wx26t	103	3	DAMPs	damps	FW
cord-018387-ci5wx26t	103	4	(	(	-LRB-
cord-018387-ci5wx26t	103	5	I	i	NN
cord-018387-ci5wx26t	103	6	)	)	-RRB-
cord-018387-ci5wx26t	103	7	,	,	,
cord-018387-ci5wx26t	103	8	present	present	JJ
cord-018387-ci5wx26t	103	9	in	in	IN
cord-018387-ci5wx26t	103	10	proteins	protein	NNS
cord-018387-ci5wx26t	103	11	released	release	VBN
cord-018387-ci5wx26t	103	12	during	during	IN
cord-018387-ci5wx26t	103	13	cell	cell	NN
cord-018387-ci5wx26t	103	14	necrosis	necrosis	NN
cord-018387-ci5wx26t	103	15	,	,	,
cord-018387-ci5wx26t	103	16	promote	promote	VB
cord-018387-ci5wx26t	103	17	sterile	sterile	JJ
cord-018387-ci5wx26t	103	18	inflammation	inflammation	NN
cord-018387-ci5wx26t	103	19	.	.	.
cord-018387-ci5wx26t	104	1	ECM	ECM	NNP
cord-018387-ci5wx26t	104	2	,	,	,
cord-018387-ci5wx26t	104	3	extracellular	extracellular	JJ
cord-018387-ci5wx26t	104	4	matrix	matrix	NN
cord-018387-ci5wx26t	104	5	;	;	:
cord-018387-ci5wx26t	104	6	HSC	HSC	NNP
cord-018387-ci5wx26t	104	7	,	,	,
cord-018387-ci5wx26t	104	8	hematopoietic	hematopoietic	JJ
cord-018387-ci5wx26t	104	9	stem	stem	NN
cord-018387-ci5wx26t	104	10	cell	cell	NN
cord-018387-ci5wx26t	104	11	;	;	:
cord-018387-ci5wx26t	104	12	TEC	TEC	NNP
cord-018387-ci5wx26t	104	13	,	,	,
cord-018387-ci5wx26t	104	14	thymic	thymic	JJ
cord-018387-ci5wx26t	104	15	epithelial	epithelial	JJ
cord-018387-ci5wx26t	104	16	cells	cell	NNS
cord-018387-ci5wx26t	104	17	;	;	:
cord-018387-ci5wx26t	104	18	ADPC	ADPC	NNP
cord-018387-ci5wx26t	104	19	,	,	,
cord-018387-ci5wx26t	104	20	adipocytes	adipocyte	NNS
cord-018387-ci5wx26t	104	21	;	;	:
cord-018387-ci5wx26t	104	22	OB	OB	NNP
cord-018387-ci5wx26t	104	23	,	,	,
cord-018387-ci5wx26t	104	24	osteoblasts	osteoblast	NNS
cord-018387-ci5wx26t	104	25	;	;	:
cord-018387-ci5wx26t	104	26	DC	DC	NNP
cord-018387-ci5wx26t	104	27	,	,	,
cord-018387-ci5wx26t	104	28	dendritic	dendritic	JJ
cord-018387-ci5wx26t	104	29	cells	cell	NNS
cord-018387-ci5wx26t	104	30	;	;	:
cord-018387-ci5wx26t	104	31	FB	fb	NN
cord-018387-ci5wx26t	104	32	,	,	,
cord-018387-ci5wx26t	104	33	fibroblasts	fibroblast	NNS
cord-018387-ci5wx26t	104	34	;	;	:
cord-018387-ci5wx26t	104	35	BM	BM	NNP
cord-018387-ci5wx26t	104	36	,	,	,
cord-018387-ci5wx26t	104	37	bone	bone	NN
cord-018387-ci5wx26t	104	38	marrow	marrow	NN
cord-018387-ci5wx26t	104	39	;	;	:
cord-018387-ci5wx26t	104	40	BC	BC	NNP
cord-018387-ci5wx26t	104	41	,	,	,
cord-018387-ci5wx26t	104	42	B	b	NN
cord-018387-ci5wx26t	104	43	cells	cell	NNS
cord-018387-ci5wx26t	104	44	;	;	:
cord-018387-ci5wx26t	104	45	TC	TC	NNP
cord-018387-ci5wx26t	104	46	,	,	,
cord-018387-ci5wx26t	104	47	T	t	NN
cord-018387-ci5wx26t	104	48	cells	cell	NNS
cord-018387-ci5wx26t	104	49	;	;	:
cord-018387-ci5wx26t	104	50	auto	auto	NN
cord-018387-ci5wx26t	104	51	-	-	HYPH
cord-018387-ci5wx26t	104	52	TC	TC	NNP
cord-018387-ci5wx26t	104	53	,	,	,
cord-018387-ci5wx26t	104	54	autoreactive	autoreactive	JJ
cord-018387-ci5wx26t	104	55	T	t	NN
cord-018387-ci5wx26t	104	56	cells	cell	NNS
cord-018387-ci5wx26t	104	57	;	;	:
cord-018387-ci5wx26t	104	58	Tregs	Tregs	NNP
cord-018387-ci5wx26t	104	59	,	,	,
cord-018387-ci5wx26t	104	60	regulatory	regulatory	JJ
cord-018387-ci5wx26t	104	61	TC	tc	NN
cord-018387-ci5wx26t	104	62	;	;	:
cord-018387-ci5wx26t	104	63	MDSCs	MDSCs	NNP
cord-018387-ci5wx26t	104	64	,	,	,
cord-018387-ci5wx26t	104	65	myeloid	myeloid	NN
cord-018387-ci5wx26t	104	66	-	-	HYPH
cord-018387-ci5wx26t	104	67	derived	derive	VBN
cord-018387-ci5wx26t	104	68	suppressor	suppressor	NN
cord-018387-ci5wx26t	104	69	cells	cell	NNS
cord-018387-ci5wx26t	104	70	;	;	:
cord-018387-ci5wx26t	104	71	ApoptB	apoptb	CC
cord-018387-ci5wx26t	104	72	,	,	,
cord-018387-ci5wx26t	104	73	apoptotic	apoptotic	JJ
cord-018387-ci5wx26t	104	74	bodies	body	NNS
cord-018387-ci5wx26t	104	75	;	;	:
cord-018387-ci5wx26t	104	76	DNA	dna	NN
cord-018387-ci5wx26t	104	77	,	,	,
cord-018387-ci5wx26t	104	78	deoxyribonucleic	deoxyribonucleic	JJ
cord-018387-ci5wx26t	104	79	acid	acid	NN
cord-018387-ci5wx26t	104	80	;	;	:
cord-018387-ci5wx26t	104	81	DAMPs	damp	NNS
cord-018387-ci5wx26t	104	82	,	,	,
cord-018387-ci5wx26t	104	83	damage	damage	NN
cord-018387-ci5wx26t	104	84	-	-	HYPH
cord-018387-ci5wx26t	104	85	associated	associate	VBN
cord-018387-ci5wx26t	104	86	molecular	molecular	JJ
cord-018387-ci5wx26t	104	87	patterns	pattern	NNS
cord-018387-ci5wx26t	104	88	;	;	:
cord-018387-ci5wx26t	104	89	SASP	SASP	NNP
cord-018387-ci5wx26t	104	90	,	,	,
cord-018387-ci5wx26t	104	91	senescence	senescence	NN
cord-018387-ci5wx26t	104	92	-	-	HYPH
cord-018387-ci5wx26t	104	93	associated	associate	VBN
cord-018387-ci5wx26t	104	94	secretory	secretory	JJ
cord-018387-ci5wx26t	104	95	phenotype	phenotype	NN
cord-018387-ci5wx26t	104	96	;	;	:
cord-018387-ci5wx26t	104	97	IL	IL	NNP
cord-018387-ci5wx26t	104	98	,	,	,
cord-018387-ci5wx26t	104	99	interleukin	interleukin	NN
cord-018387-ci5wx26t	104	100	;	;	:
cord-018387-ci5wx26t	104	101	Auto	Auto	NNP
cord-018387-ci5wx26t	104	102	-	-	HYPH
cord-018387-ci5wx26t	104	103	Ab	Ab	NNP
cord-018387-ci5wx26t	104	104	,	,	,
cord-018387-ci5wx26t	104	105	autoantibodies	autoantibody	NNS
cord-018387-ci5wx26t	104	106	.	.	.
cord-018387-ci5wx26t	105	1	(	(	-LRB-
cord-018387-ci5wx26t	105	2	Modified	modify	VBN
cord-018387-ci5wx26t	105	3	from	from	IN
cord-018387-ci5wx26t	105	4	Müller	Müller	NNP
cord-018387-ci5wx26t	105	5	and	and	CC
cord-018387-ci5wx26t	105	6	Pawelec	Pawelec	NNP
cord-018387-ci5wx26t	105	7	[	[	-LRB-
cord-018387-ci5wx26t	105	8	18	18	CD
cord-018387-ci5wx26t	105	9	]	]	-RRB-
cord-018387-ci5wx26t	105	10	)	)	-RRB-
cord-018387-ci5wx26t	106	1	genic	genic	NNP
cord-018387-ci5wx26t	106	2	immune	immune	JJ
cord-018387-ci5wx26t	106	3	responses	response	NNS
cord-018387-ci5wx26t	106	4	[	[	-LRB-
cord-018387-ci5wx26t	106	5	18	18	CD
cord-018387-ci5wx26t	106	6	]	]	-RRB-
cord-018387-ci5wx26t	106	7	.	.	.
cord-018387-ci5wx26t	107	1	Early	early	JJ
cord-018387-ci5wx26t	107	2	data	datum	NNS
cord-018387-ci5wx26t	107	3	indicated	indicate	VBD
cord-018387-ci5wx26t	107	4	that	that	IN
cord-018387-ci5wx26t	107	5	younger	young	JJR
cord-018387-ci5wx26t	107	6	and	and	CC
cord-018387-ci5wx26t	107	7	older	old	JJR
cord-018387-ci5wx26t	107	8	people	people	NNS
cord-018387-ci5wx26t	107	9	possessed	possess	VBD
cord-018387-ci5wx26t	107	10	phenotypically	phenotypically	RB
cord-018387-ci5wx26t	107	11	identical	identical	JJ
cord-018387-ci5wx26t	107	12	Tregs	Tregs	NNP
cord-018387-ci5wx26t	107	13	but	but	CC
cord-018387-ci5wx26t	107	14	that	that	IN
cord-018387-ci5wx26t	107	15	suppressive	suppressive	JJ
cord-018387-ci5wx26t	107	16	function	function	NN
cord-018387-ci5wx26t	107	17	waned	wane	VBD
cord-018387-ci5wx26t	107	18	in	in	IN
cord-018387-ci5wx26t	107	19	the	the	DT
cord-018387-ci5wx26t	107	20	latter	latter	JJ
cord-018387-ci5wx26t	107	21	[	[	-LRB-
cord-018387-ci5wx26t	107	22	48	48	CD
cord-018387-ci5wx26t	107	23	]	]	-RRB-
cord-018387-ci5wx26t	107	24	.	.	.
cord-018387-ci5wx26t	108	1	More	More	JJR
cord-018387-ci5wx26t	108	2	recent	recent	JJ
cord-018387-ci5wx26t	108	3	data	datum	NNS
cord-018387-ci5wx26t	108	4	confirm	confirm	VBP
cord-018387-ci5wx26t	108	5	that	that	IN
cord-018387-ci5wx26t	108	6	aging	age	VBG
cord-018387-ci5wx26t	108	7	significantly	significantly	RB
cord-018387-ci5wx26t	108	8	affects	affect	VBZ
cord-018387-ci5wx26t	108	9	the	the	DT
cord-018387-ci5wx26t	108	10	generation	generation	NN
cord-018387-ci5wx26t	108	11	,	,	,
cord-018387-ci5wx26t	108	12	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	108	13	,	,	,
cord-018387-ci5wx26t	108	14	diversity	diversity	NN
cord-018387-ci5wx26t	108	15	,	,	,
cord-018387-ci5wx26t	108	16	and	and	CC
cord-018387-ci5wx26t	108	17	functional	functional	JJ
cord-018387-ci5wx26t	108	18	competence	competence	NN
cord-018387-ci5wx26t	108	19	of	of	IN
cord-018387-ci5wx26t	108	20	Tregs	Tregs	NNP
cord-018387-ci5wx26t	108	21	.	.	.
cord-018387-ci5wx26t	109	1	A	a	DT
cord-018387-ci5wx26t	109	2	decline	decline	NN
cord-018387-ci5wx26t	109	3	of	of	IN
cord-018387-ci5wx26t	109	4	thymic	thymic	JJ
cord-018387-ci5wx26t	109	5	function	function	NN
cord-018387-ci5wx26t	109	6	disturbs	disturb	VBZ
cord-018387-ci5wx26t	109	7	the	the	DT
cord-018387-ci5wx26t	109	8	thymic	thymic	JJ
cord-018387-ci5wx26t	109	9	Treg	Treg	NNP
cord-018387-ci5wx26t	109	10	production	production	NN
cord-018387-ci5wx26t	109	11	and	and	CC
cord-018387-ci5wx26t	109	12	also	also	RB
cord-018387-ci5wx26t	109	13	seems	seem	VBZ
cord-018387-ci5wx26t	109	14	to	to	TO
cord-018387-ci5wx26t	109	15	be	be	VB
cord-018387-ci5wx26t	109	16	compensated	compensate	VBN
cord-018387-ci5wx26t	109	17	for	for	IN
cord-018387-ci5wx26t	109	18	through	through	IN
cord-018387-ci5wx26t	109	19	the	the	DT
cord-018387-ci5wx26t	109	20	peripheral	peripheral	JJ
cord-018387-ci5wx26t	109	21	expansion	expansion	NN
cord-018387-ci5wx26t	109	22	of	of	IN
cord-018387-ci5wx26t	109	23	pre	pre	JJ
cord-018387-ci5wx26t	109	24	-	-	JJ
cord-018387-ci5wx26t	109	25	existing	existing	JJ
cord-018387-ci5wx26t	109	26	Tregs	Tregs	NNP
cord-018387-ci5wx26t	109	27	and/or	and/or	CC
cord-018387-ci5wx26t	109	28	through	through	IN
cord-018387-ci5wx26t	109	29	the	the	DT
cord-018387-ci5wx26t	109	30	conversion	conversion	NN
cord-018387-ci5wx26t	109	31	of	of	IN
cord-018387-ci5wx26t	109	32	conventional	conventional	JJ
cord-018387-ci5wx26t	109	33	T	t	NN
cord-018387-ci5wx26t	109	34	cells	cell	NNS
cord-018387-ci5wx26t	109	35	into	into	IN
cord-018387-ci5wx26t	109	36	Tregs	Tregs	NNP
cord-018387-ci5wx26t	109	37	[	[	-LRB-
cord-018387-ci5wx26t	109	38	49	49	CD
cord-018387-ci5wx26t	109	39	]	]	-RRB-
cord-018387-ci5wx26t	109	40	,	,	,
cord-018387-ci5wx26t	109	41	as	as	IN
cord-018387-ci5wx26t	109	42	had	have	VBD
cord-018387-ci5wx26t	109	43	been	be	VBN
cord-018387-ci5wx26t	109	44	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	109	45	using	use	VBG
cord-018387-ci5wx26t	109	46	T	t	NN
cord-018387-ci5wx26t	109	47	-	-	HYPH
cord-018387-ci5wx26t	109	48	cell	cell	NN
cord-018387-ci5wx26t	109	49	clonal	clonal	JJ
cord-018387-ci5wx26t	109	50	culture	culture	NN
cord-018387-ci5wx26t	109	51	models	model	NNS
cord-018387-ci5wx26t	109	52	much	much	RB
cord-018387-ci5wx26t	109	53	earlier	early	RBR
cord-018387-ci5wx26t	109	54	[	[	-LRB-
cord-018387-ci5wx26t	109	55	50	50	CD
cord-018387-ci5wx26t	109	56	]	]	-RRB-
cord-018387-ci5wx26t	109	57	.	.	.
cord-018387-ci5wx26t	110	1	Thus	thus	RB
cord-018387-ci5wx26t	110	2	,	,	,
cord-018387-ci5wx26t	110	3	due	due	IN
cord-018387-ci5wx26t	110	4	to	to	IN
cord-018387-ci5wx26t	110	5	the	the	DT
cord-018387-ci5wx26t	110	6	leading	leading	JJ
cord-018387-ci5wx26t	110	7	role	role	NN
cord-018387-ci5wx26t	110	8	of	of	IN
cord-018387-ci5wx26t	110	9	Tregs	Tregs	NNP
cord-018387-ci5wx26t	110	10	in	in	IN
cord-018387-ci5wx26t	110	11	immune	immune	JJ
cord-018387-ci5wx26t	110	12	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	110	13	,	,	,
cord-018387-ci5wx26t	110	14	an	an	DT
cord-018387-ci5wx26t	110	15	age	age	NN
cord-018387-ci5wx26t	110	16	-	-	HYPH
cord-018387-ci5wx26t	110	17	related	relate	VBN
cord-018387-ci5wx26t	110	18	deterioration	deterioration	NN
cord-018387-ci5wx26t	110	19	of	of	IN
cord-018387-ci5wx26t	110	20	Tregs	Tregs	NNP
cord-018387-ci5wx26t	110	21	(	(	-LRB-
cord-018387-ci5wx26t	110	22	Fig	Fig	NNP
cord-018387-ci5wx26t	110	23	.	.	.
cord-018387-ci5wx26t	110	24	14	14	CD
cord-018387-ci5wx26t	110	25	.	.	.
cord-018387-ci5wx26t	110	26	1	1	LS
cord-018387-ci5wx26t	110	27	)	)	-RRB-
cord-018387-ci5wx26t	110	28	might	may	MD
cord-018387-ci5wx26t	110	29	induce	induce	VB
cord-018387-ci5wx26t	110	30	either	either	CC
cord-018387-ci5wx26t	110	31	excessive	excessive	JJ
cord-018387-ci5wx26t	110	32	immunity	immunity	NN
cord-018387-ci5wx26t	110	33	(	(	-LRB-
cord-018387-ci5wx26t	110	34	impacting	impact	VBG
cord-018387-ci5wx26t	110	35	a	a	DT
cord-018387-ci5wx26t	110	36	chronic	chronic	JJ
cord-018387-ci5wx26t	110	37	inflammation	inflammation	NN
cord-018387-ci5wx26t	110	38	as	as	RB
cord-018387-ci5wx26t	110	39	well	well	RB
cord-018387-ci5wx26t	110	40	as	as	IN
cord-018387-ci5wx26t	110	41	increasing	increase	VBG
cord-018387-ci5wx26t	110	42	the	the	DT
cord-018387-ci5wx26t	110	43	risk	risk	NN
cord-018387-ci5wx26t	110	44	for	for	IN
cord-018387-ci5wx26t	110	45	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	110	46	)	)	-RRB-
cord-018387-ci5wx26t	110	47	or	or	CC
cord-018387-ci5wx26t	110	48	,	,	,
cord-018387-ci5wx26t	110	49	conversely	conversely	RB
cord-018387-ci5wx26t	110	50	,	,	,
cord-018387-ci5wx26t	110	51	an	an	DT
cord-018387-ci5wx26t	110	52	age	age	NN
cord-018387-ci5wx26t	110	53	-	-	HYPH
cord-018387-ci5wx26t	110	54	related	relate	VBN
cord-018387-ci5wx26t	110	55	increase	increase	NN
cord-018387-ci5wx26t	110	56	of	of	IN
cord-018387-ci5wx26t	110	57	Treg	Treg	NNP
cord-018387-ci5wx26t	110	58	activity	activity	NN
cord-018387-ci5wx26t	110	59	might	may	MD
cord-018387-ci5wx26t	110	60	result	result	VB
cord-018387-ci5wx26t	110	61	in	in	IN
cord-018387-ci5wx26t	110	62	failing	fail	VBG
cord-018387-ci5wx26t	110	63	immunity	immunity	NN
cord-018387-ci5wx26t	110	64	(	(	-LRB-
cord-018387-ci5wx26t	110	65	raising	raise	VBG
cord-018387-ci5wx26t	110	66	the	the	DT
cord-018387-ci5wx26t	110	67	risk	risk	NN
cord-018387-ci5wx26t	110	68	of	of	IN
cord-018387-ci5wx26t	110	69	malignancies	malignancy	NNS
cord-018387-ci5wx26t	110	70	and	and	CC
cord-018387-ci5wx26t	110	71	infectious	infectious	JJ
cord-018387-ci5wx26t	110	72	diseases	disease	NNS
cord-018387-ci5wx26t	110	73	)	)	-RRB-
cord-018387-ci5wx26t	110	74	in	in	IN
cord-018387-ci5wx26t	110	75	the	the	DT
cord-018387-ci5wx26t	110	76	elderly	elderly	JJ
cord-018387-ci5wx26t	110	77	[	[	-LRB-
cord-018387-ci5wx26t	110	78	49	49	CD
cord-018387-ci5wx26t	110	79	,	,	,
cord-018387-ci5wx26t	110	80	51	51	CD
cord-018387-ci5wx26t	110	81	,	,	,
cord-018387-ci5wx26t	110	82	52	52	CD
cord-018387-ci5wx26t	110	83	]	]	-RRB-
cord-018387-ci5wx26t	110	84	.	.	.
cord-018387-ci5wx26t	111	1	As	as	IN
cord-018387-ci5wx26t	111	2	we	-PRON-	PRP
cord-018387-ci5wx26t	111	3	age	age	VBP
cord-018387-ci5wx26t	111	4	,	,	,
cord-018387-ci5wx26t	111	5	the	the	DT
cord-018387-ci5wx26t	111	6	maintenance	maintenance	NN
cord-018387-ci5wx26t	111	7	of	of	IN
cord-018387-ci5wx26t	111	8	homeostatic	homeostatic	JJ
cord-018387-ci5wx26t	111	9	conditions	condition	NNS
cord-018387-ci5wx26t	111	10	may	may	MD
cord-018387-ci5wx26t	111	11	become	become	VB
cord-018387-ci5wx26t	111	12	compromised	compromised	JJ
cord-018387-ci5wx26t	111	13	[	[	-LRB-
cord-018387-ci5wx26t	111	14	18	18	CD
cord-018387-ci5wx26t	111	15	]	]	-RRB-
cord-018387-ci5wx26t	111	16	.	.	.
cord-018387-ci5wx26t	112	1	The	the	DT
cord-018387-ci5wx26t	112	2	consequence	consequence	NN
cord-018387-ci5wx26t	112	3	of	of	IN
cord-018387-ci5wx26t	112	4	this	this	DT
cord-018387-ci5wx26t	112	5	imbalance	imbalance	NN
cord-018387-ci5wx26t	112	6	may	may	MD
cord-018387-ci5wx26t	112	7	be	be	VB
cord-018387-ci5wx26t	112	8	that	that	IN
cord-018387-ci5wx26t	112	9	immunity	immunity	NN
cord-018387-ci5wx26t	112	10	is	be	VBZ
cord-018387-ci5wx26t	112	11	redirected	redirect	VBN
cord-018387-ci5wx26t	112	12	toward	toward	IN
cord-018387-ci5wx26t	112	13	the	the	DT
cord-018387-ci5wx26t	112	14	innate	innate	JJ
cord-018387-ci5wx26t	112	15	immune	immune	JJ
cord-018387-ci5wx26t	112	16	responses	response	NNS
cord-018387-ci5wx26t	112	17	,	,	,
cord-018387-ci5wx26t	112	18	characterized	characterize	VBN
cord-018387-ci5wx26t	112	19	by	by	IN
cord-018387-ci5wx26t	112	20	increased	increase	VBN
cord-018387-ci5wx26t	112	21	levels	level	NNS
cord-018387-ci5wx26t	112	22	of	of	IN
cord-018387-ci5wx26t	112	23	systemic	systemic	JJ
cord-018387-ci5wx26t	112	24	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	112	25	molecules	molecule	NNS
cord-018387-ci5wx26t	112	26	-a	-a	IN
cord-018387-ci5wx26t	112	27	phenomenon	phenomenon	NN
cord-018387-ci5wx26t	112	28	dubbed	dub	VBN
cord-018387-ci5wx26t	112	29	as	as	IN
cord-018387-ci5wx26t	112	30	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	112	31	[	[	-LRB-
cord-018387-ci5wx26t	112	32	44	44	CD
cord-018387-ci5wx26t	112	33	]	]	-RRB-
cord-018387-ci5wx26t	112	34	.	.	.
cord-018387-ci5wx26t	113	1	Large	large	JJ
cord-018387-ci5wx26t	113	2	epidemiologic	epidemiologic	JJ
cord-018387-ci5wx26t	113	3	studies	study	NNS
cord-018387-ci5wx26t	113	4	commonly	commonly	RB
cord-018387-ci5wx26t	113	5	report	report	VBP
cord-018387-ci5wx26t	113	6	about	about	IN
cord-018387-ci5wx26t	113	7	elevated	elevated	JJ
cord-018387-ci5wx26t	113	8	levels	level	NNS
cord-018387-ci5wx26t	113	9	of	of	IN
cord-018387-ci5wx26t	113	10	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	113	11	factors	factor	NNS
cord-018387-ci5wx26t	113	12	such	such	JJ
cord-018387-ci5wx26t	113	13	as	as	IN
cord-018387-ci5wx26t	113	14	CRP	CRP	NNP
cord-018387-ci5wx26t	113	15	,	,	,
cord-018387-ci5wx26t	113	16	IL-6	IL-6	NNP
cord-018387-ci5wx26t	113	17	,	,	,
cord-018387-ci5wx26t	113	18	and	and	CC
cord-018387-ci5wx26t	113	19	TNF	TNF	NNP
cord-018387-ci5wx26t	113	20	in	in	IN
cord-018387-ci5wx26t	113	21	the	the	DT
cord-018387-ci5wx26t	113	22	peripheral	peripheral	JJ
cord-018387-ci5wx26t	113	23	blood	blood	NN
cord-018387-ci5wx26t	113	24	of	of	IN
cord-018387-ci5wx26t	113	25	elderly	elderly	JJ
cord-018387-ci5wx26t	113	26	people	people	NNS
cord-018387-ci5wx26t	113	27	[	[	-LRB-
cord-018387-ci5wx26t	113	28	53	53	CD
cord-018387-ci5wx26t	113	29	]	]	-RRB-
cord-018387-ci5wx26t	113	30	.	.	.
cord-018387-ci5wx26t	114	1	Elevated	elevated	JJ
cord-018387-ci5wx26t	114	2	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	114	3	immune	immune	JJ
cord-018387-ci5wx26t	114	4	mediators	mediator	NNS
cord-018387-ci5wx26t	114	5	(	(	-LRB-
cord-018387-ci5wx26t	114	6	Fig	Fig	NNP
cord-018387-ci5wx26t	114	7	.	.	NNP
cord-018387-ci5wx26t	114	8	14.1	14.1	CD
cord-018387-ci5wx26t	114	9	)	)	-RRB-
cord-018387-ci5wx26t	114	10	are	be	VBP
cord-018387-ci5wx26t	114	11	thought	think	VBN
cord-018387-ci5wx26t	114	12	to	to	TO
cord-018387-ci5wx26t	114	13	be	be	VB
cord-018387-ci5wx26t	114	14	involved	involve	VBN
cord-018387-ci5wx26t	114	15	in	in	IN
cord-018387-ci5wx26t	114	16	most	most	JJS
cord-018387-ci5wx26t	114	17	age	age	NN
cord-018387-ci5wx26t	114	18	-	-	HYPH
cord-018387-ci5wx26t	114	19	related	relate	VBN
cord-018387-ci5wx26t	114	20	chronic	chronic	NN
cord-018387-ci5wx26t	114	21	and	and	CC
cord-018387-ci5wx26t	114	22	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	114	23	diseases	disease	NNS
cord-018387-ci5wx26t	114	24	as	as	RB
cord-018387-ci5wx26t	114	25	well	well	RB
cord-018387-ci5wx26t	114	26	as	as	IN
cord-018387-ci5wx26t	114	27	carcinogenesis	carcinogenesis	NN
cord-018387-ci5wx26t	114	28	.	.	.
cord-018387-ci5wx26t	115	1	Over	over	IN
cord-018387-ci5wx26t	115	2	the	the	DT
cord-018387-ci5wx26t	115	3	life	life	NN
cord-018387-ci5wx26t	115	4	course	course	NN
cord-018387-ci5wx26t	115	5	,	,	,
cord-018387-ci5wx26t	115	6	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	115	7	stimuli	stimulus	NNS
cord-018387-ci5wx26t	115	8	from	from	IN
cord-018387-ci5wx26t	115	9	pathogen	pathogen	NN
cord-018387-ci5wx26t	115	10	sources	source	NNS
cord-018387-ci5wx26t	115	11	are	be	VBP
cord-018387-ci5wx26t	115	12	likely	likely	JJ
cord-018387-ci5wx26t	115	13	to	to	TO
cord-018387-ci5wx26t	115	14	become	become	VB
cord-018387-ci5wx26t	115	15	increasingly	increasingly	RB
cord-018387-ci5wx26t	115	16	entangled	entangle	VBN
cord-018387-ci5wx26t	115	17	with	with	IN
cord-018387-ci5wx26t	115	18	endogenous	endogenous	JJ
cord-018387-ci5wx26t	115	19	stimuli	stimulus	NNS
cord-018387-ci5wx26t	115	20	.	.	.
cord-018387-ci5wx26t	116	1	One	one	CD
cord-018387-ci5wx26t	116	2	possible	possible	JJ
cord-018387-ci5wx26t	116	3	source	source	NN
cord-018387-ci5wx26t	116	4	of	of	IN
cord-018387-ci5wx26t	116	5	this	this	DT
cord-018387-ci5wx26t	116	6	endogenous	endogenous	JJ
cord-018387-ci5wx26t	116	7	"	"	``
cord-018387-ci5wx26t	116	8	noise	noise	NN
cord-018387-ci5wx26t	116	9	"	"	''
cord-018387-ci5wx26t	116	10	is	be	VBZ
cord-018387-ci5wx26t	116	11	the	the	DT
cord-018387-ci5wx26t	116	12	senescence	senescence	NN
cord-018387-ci5wx26t	116	13	-	-	HYPH
cord-018387-ci5wx26t	116	14	associated	associate	VBN
cord-018387-ci5wx26t	116	15	secretory	secretory	JJ
cord-018387-ci5wx26t	116	16	phenotype	phenotype	NN
cord-018387-ci5wx26t	116	17	(	(	-LRB-
cord-018387-ci5wx26t	116	18	SASP	SASP	NNP
cord-018387-ci5wx26t	116	19	)	)	-RRB-
cord-018387-ci5wx26t	116	20	characterizing	characterize	VBG
cord-018387-ci5wx26t	116	21	the	the	DT
cord-018387-ci5wx26t	116	22	accumulating	accumulate	VBG
cord-018387-ci5wx26t	116	23	"	"	``
cord-018387-ci5wx26t	116	24	senescent	senescent	JJ
cord-018387-ci5wx26t	116	25	"	"	''
cord-018387-ci5wx26t	116	26	cells	cell	NNS
cord-018387-ci5wx26t	116	27	in	in	IN
cord-018387-ci5wx26t	116	28	the	the	DT
cord-018387-ci5wx26t	116	29	elderly	elderly	JJ
cord-018387-ci5wx26t	116	30	that	that	WDT
cord-018387-ci5wx26t	116	31	can	can	MD
cord-018387-ci5wx26t	116	32	affect	affect	VB
cord-018387-ci5wx26t	116	33	the	the	DT
cord-018387-ci5wx26t	116	34	behavior	behavior	NN
cord-018387-ci5wx26t	116	35	of	of	IN
cord-018387-ci5wx26t	116	36	neighboring	neighboring	NN
cord-018387-ci5wx26t	116	37	cells	cell	NNS
cord-018387-ci5wx26t	116	38	[	[	-LRB-
cord-018387-ci5wx26t	116	39	54	54	CD
cord-018387-ci5wx26t	116	40	,	,	,
cord-018387-ci5wx26t	116	41	55	55	CD
cord-018387-ci5wx26t	116	42	]	]	-RRB-
cord-018387-ci5wx26t	116	43	.	.	.
cord-018387-ci5wx26t	117	1	The	the	DT
cord-018387-ci5wx26t	117	2	SASP	SASP	NNP
cord-018387-ci5wx26t	117	3	is	be	VBZ
cord-018387-ci5wx26t	117	4	a	a	DT
cord-018387-ci5wx26t	117	5	spectrum	spectrum	NN
cord-018387-ci5wx26t	117	6	of	of	IN
cord-018387-ci5wx26t	117	7	pro	pro	JJ
cord-018387-ci5wx26t	117	8	-	-	JJ
cord-018387-ci5wx26t	117	9	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	117	10	proteins	protein	NNS
cord-018387-ci5wx26t	117	11	and	and	CC
cord-018387-ci5wx26t	117	12	cytokines	cytokine	NNS
cord-018387-ci5wx26t	117	13	secreted	secrete	VBN
cord-018387-ci5wx26t	117	14	by	by	IN
cord-018387-ci5wx26t	117	15	such	such	JJ
cord-018387-ci5wx26t	117	16	cells	cell	NNS
cord-018387-ci5wx26t	117	17	,	,	,
cord-018387-ci5wx26t	117	18	which	which	WDT
cord-018387-ci5wx26t	117	19	have	have	VBP
cord-018387-ci5wx26t	117	20	permanently	permanently	RB
cord-018387-ci5wx26t	117	21	exited	exit	VBN
cord-018387-ci5wx26t	117	22	the	the	DT
cord-018387-ci5wx26t	117	23	cell	cell	NN
cord-018387-ci5wx26t	117	24	cycle	cycle	NN
cord-018387-ci5wx26t	117	25	and	and	CC
cord-018387-ci5wx26t	117	26	are	be	VBP
cord-018387-ci5wx26t	117	27	known	know	VBN
cord-018387-ci5wx26t	117	28	to	to	TO
cord-018387-ci5wx26t	117	29	accumulate	accumulate	VB
cord-018387-ci5wx26t	117	30	in	in	IN
cord-018387-ci5wx26t	117	31	the	the	DT
cord-018387-ci5wx26t	117	32	periphery	periphery	NN
cord-018387-ci5wx26t	117	33	to	to	IN
cord-018387-ci5wx26t	117	34	significant	significant	JJ
cord-018387-ci5wx26t	117	35	numbers	number	NNS
cord-018387-ci5wx26t	117	36	with	with	IN
cord-018387-ci5wx26t	117	37	advancing	advance	VBG
cord-018387-ci5wx26t	117	38	age	age	NN
cord-018387-ci5wx26t	117	39	[	[	-LRB-
cord-018387-ci5wx26t	117	40	56	56	CD
cord-018387-ci5wx26t	117	41	,	,	,
cord-018387-ci5wx26t	117	42	57	57	CD
cord-018387-ci5wx26t	117	43	]	]	-RRB-
cord-018387-ci5wx26t	117	44	.	.	.
cord-018387-ci5wx26t	118	1	This	this	DT
cord-018387-ci5wx26t	118	2	process	process	NN
cord-018387-ci5wx26t	118	3	is	be	VBZ
cord-018387-ci5wx26t	118	4	also	also	RB
cord-018387-ci5wx26t	118	5	associated	associate	VBN
cord-018387-ci5wx26t	118	6	with	with	IN
cord-018387-ci5wx26t	118	7	the	the	DT
cord-018387-ci5wx26t	118	8	activation	activation	NN
cord-018387-ci5wx26t	118	9	of	of	IN
cord-018387-ci5wx26t	118	10	self	self	NN
cord-018387-ci5wx26t	118	11	-	-	HYPH
cord-018387-ci5wx26t	118	12	reactive	reactive	JJ
cord-018387-ci5wx26t	118	13	memory	memory	NN
cord-018387-ci5wx26t	118	14	B	b	NN
cord-018387-ci5wx26t	118	15	cells	cell	NNS
cord-018387-ci5wx26t	118	16	,	,	,
cord-018387-ci5wx26t	118	17	producing	produce	VBG
cord-018387-ci5wx26t	118	18	increased	increase	VBN
cord-018387-ci5wx26t	118	19	levels	level	NNS
cord-018387-ci5wx26t	118	20	of	of	IN
cord-018387-ci5wx26t	118	21	autoantibodies	autoantibody	NNS
cord-018387-ci5wx26t	118	22	(	(	-LRB-
cord-018387-ci5wx26t	118	23	Fig	Fig	NNP
cord-018387-ci5wx26t	118	24	.	.	NNP
cord-018387-ci5wx26t	118	25	14.1	14.1	CD
cord-018387-ci5wx26t	118	26	)	)	-RRB-
cord-018387-ci5wx26t	118	27	,	,	,
cord-018387-ci5wx26t	118	28	which	which	WDT
cord-018387-ci5wx26t	118	29	are	be	VBP
cord-018387-ci5wx26t	118	30	frequent	frequent	JJ
cord-018387-ci5wx26t	118	31	in	in	IN
cord-018387-ci5wx26t	118	32	aged	aged	JJ
cord-018387-ci5wx26t	118	33	individuals	individual	NNS
cord-018387-ci5wx26t	118	34	as	as	IN
cord-018387-ci5wx26t	118	35	a	a	DT
cord-018387-ci5wx26t	118	36	result	result	NN
cord-018387-ci5wx26t	118	37	of	of	IN
cord-018387-ci5wx26t	118	38	tissue	tissue	NN
cord-018387-ci5wx26t	118	39	damage	damage	NN
cord-018387-ci5wx26t	118	40	and	and	CC
cord-018387-ci5wx26t	118	41	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	118	42	[	[	-LRB-
cord-018387-ci5wx26t	118	43	58	58	CD
cord-018387-ci5wx26t	118	44	]	]	-RRB-
cord-018387-ci5wx26t	118	45	.	.	.
cord-018387-ci5wx26t	119	1	Repetitive	repetitive	JJ
cord-018387-ci5wx26t	119	2	antigenic	antigenic	JJ
cord-018387-ci5wx26t	119	3	challenges	challenge	NNS
cord-018387-ci5wx26t	119	4	over	over	IN
cord-018387-ci5wx26t	119	5	a	a	DT
cord-018387-ci5wx26t	119	6	lifetime	lifetime	NN
cord-018387-ci5wx26t	119	7	(	(	-LRB-
cord-018387-ci5wx26t	119	8	Figs	fig	NNS
cord-018387-ci5wx26t	119	9	.	.	.
cord-018387-ci5wx26t	119	10	14.1	14.1	CD
cord-018387-ci5wx26t	119	11	and	and	CC
cord-018387-ci5wx26t	119	12	14.2	14.2	CD
cord-018387-ci5wx26t	119	13	)	)	-RRB-
cord-018387-ci5wx26t	119	14	may	may	MD
cord-018387-ci5wx26t	119	15	stimulate	stimulate	VB
cord-018387-ci5wx26t	119	16	pro	pro	JJ
cord-018387-ci5wx26t	119	17	-	-	JJ
cord-018387-ci5wx26t	119	18	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	119	19	cytokines	cytokine	NNS
cord-018387-ci5wx26t	119	20	,	,	,
cord-018387-ci5wx26t	119	21	contributing	contribute	VBG
cord-018387-ci5wx26t	119	22	to	to	IN
cord-018387-ci5wx26t	119	23	the	the	DT
cord-018387-ci5wx26t	119	24	maintenance	maintenance	NN
cord-018387-ci5wx26t	119	25	of	of	IN
cord-018387-ci5wx26t	119	26	persistent	persistent	JJ
cord-018387-ci5wx26t	119	27	chronic	chronic	JJ
cord-018387-ci5wx26t	119	28	inflammation	inflammation	NN
cord-018387-ci5wx26t	119	29	[	[	-LRB-
cord-018387-ci5wx26t	119	30	59	59	CD
cord-018387-ci5wx26t	119	31	]	]	-RRB-
cord-018387-ci5wx26t	119	32	.	.	.
cord-018387-ci5wx26t	120	1	Such	such	JJ
cord-018387-ci5wx26t	120	2	persistent	persistent	JJ
cord-018387-ci5wx26t	120	3	age	age	NN
cord-018387-ci5wx26t	120	4	-	-	HYPH
cord-018387-ci5wx26t	120	5	related	relate	VBN
cord-018387-ci5wx26t	120	6	chronic	chronic	JJ
cord-018387-ci5wx26t	120	7	inflammation	inflammation	NN
cord-018387-ci5wx26t	120	8	represents	represent	VBZ
cord-018387-ci5wx26t	120	9	an	an	DT
cord-018387-ci5wx26t	120	10	extreme	extreme	JJ
cord-018387-ci5wx26t	120	11	stress	stress	NN
cord-018387-ci5wx26t	120	12	factor	factor	NN
cord-018387-ci5wx26t	120	13	for	for	IN
cord-018387-ci5wx26t	120	14	the	the	DT
cord-018387-ci5wx26t	120	15	immune	immune	JJ
cord-018387-ci5wx26t	120	16	system	system	NN
cord-018387-ci5wx26t	120	17	,	,	,
cord-018387-ci5wx26t	120	18	causing	cause	VBG
cord-018387-ci5wx26t	120	19	eventual	eventual	JJ
cord-018387-ci5wx26t	120	20	exhaustion	exhaustion	NN
cord-018387-ci5wx26t	120	21	.	.	.
cord-018387-ci5wx26t	121	1	Autoimmunity	Autoimmunity	NNP
cord-018387-ci5wx26t	121	2	is	be	VBZ
cord-018387-ci5wx26t	121	3	associated	associate	VBN
cord-018387-ci5wx26t	121	4	with	with	IN
cord-018387-ci5wx26t	121	5	what	what	WP
cord-018387-ci5wx26t	121	6	could	could	MD
cord-018387-ci5wx26t	121	7	be	be	VB
cord-018387-ci5wx26t	121	8	considered	consider	VBN
cord-018387-ci5wx26t	121	9	premature	premature	JJ
cord-018387-ci5wx26t	121	10	immune	immune	JJ
cord-018387-ci5wx26t	121	11	aging	aging	NN
cord-018387-ci5wx26t	121	12	,	,	,
cord-018387-ci5wx26t	121	13	demonstrating	demonstrate	VBG
cord-018387-ci5wx26t	121	14	the	the	DT
cord-018387-ci5wx26t	121	15	relationship	relationship	NN
cord-018387-ci5wx26t	121	16	between	between	IN
cord-018387-ci5wx26t	121	17	chronic	chronic	JJ
cord-018387-ci5wx26t	121	18	immune	immune	JJ
cord-018387-ci5wx26t	121	19	stimulation	stimulation	NN
cord-018387-ci5wx26t	121	20	and	and	CC
cord-018387-ci5wx26t	121	21	progressive	progressive	JJ
cord-018387-ci5wx26t	121	22	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	121	23	[	[	-LRB-
cord-018387-ci5wx26t	121	24	18	18	CD
cord-018387-ci5wx26t	121	25	,	,	,
cord-018387-ci5wx26t	121	26	60	60	CD
cord-018387-ci5wx26t	121	27	]	]	-RRB-
cord-018387-ci5wx26t	121	28	.	.	.
cord-018387-ci5wx26t	122	1	According	accord	VBG
cord-018387-ci5wx26t	122	2	to	to	IN
cord-018387-ci5wx26t	122	3	the	the	DT
cord-018387-ci5wx26t	122	4	current	current	JJ
cord-018387-ci5wx26t	122	5	paradigm	paradigm	NN
cord-018387-ci5wx26t	122	6	,	,	,
cord-018387-ci5wx26t	122	7	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	122	8	develops	develop	VBZ
cord-018387-ci5wx26t	122	9	when	when	WRB
cord-018387-ci5wx26t	122	10	self	self	NN
cord-018387-ci5wx26t	122	11	-	-	HYPH
cord-018387-ci5wx26t	122	12	reactive	reactive	JJ
cord-018387-ci5wx26t	122	13	B	B	NNP
cord-018387-ci5wx26t	122	14	and	and	CC
cord-018387-ci5wx26t	122	15	T	t	NN
cord-018387-ci5wx26t	122	16	cells	cell	NNS
cord-018387-ci5wx26t	122	17	(	(	-LRB-
cord-018387-ci5wx26t	122	18	Fig	Fig	NNP
cord-018387-ci5wx26t	122	19	.	.	NNP
cord-018387-ci5wx26t	122	20	14.1	14.1	CD
cord-018387-ci5wx26t	122	21	)	)	-RRB-
cord-018387-ci5wx26t	122	22	recognize	recognize	VBP
cord-018387-ci5wx26t	122	23	a	a	DT
cord-018387-ci5wx26t	122	24	self	self	NN
cord-018387-ci5wx26t	122	25	-	-	HYPH
cord-018387-ci5wx26t	122	26	antigen	antigen	NN
cord-018387-ci5wx26t	122	27	and	and	CC
cord-018387-ci5wx26t	122	28	differentiate	differentiate	VB
cord-018387-ci5wx26t	122	29	into	into	IN
cord-018387-ci5wx26t	122	30	memory	memory	NN
cord-018387-ci5wx26t	122	31	and	and	CC
cord-018387-ci5wx26t	122	32	effector	effector	NN
cord-018387-ci5wx26t	122	33	cells	cell	NNS
cord-018387-ci5wx26t	122	34	due	due	JJ
cord-018387-ci5wx26t	122	35	to	to	IN
cord-018387-ci5wx26t	122	36	the	the	DT
cord-018387-ci5wx26t	122	37	breakdown	breakdown	NN
cord-018387-ci5wx26t	122	38	of	of	IN
cord-018387-ci5wx26t	122	39	the	the	DT
cord-018387-ci5wx26t	122	40	control	control	NN
cord-018387-ci5wx26t	122	41	of	of	IN
cord-018387-ci5wx26t	122	42	autoreactivity	autoreactivity	NNP
cord-018387-ci5wx26t	122	43	[	[	-LRB-
cord-018387-ci5wx26t	122	44	15	15	CD
cord-018387-ci5wx26t	122	45	]	]	-RRB-
cord-018387-ci5wx26t	122	46	.	.	.
cord-018387-ci5wx26t	123	1	It	-PRON-	PRP
cord-018387-ci5wx26t	123	2	can	can	MD
cord-018387-ci5wx26t	123	3	occur	occur	VB
cord-018387-ci5wx26t	123	4	by	by	IN
cord-018387-ci5wx26t	123	5	a	a	DT
cord-018387-ci5wx26t	123	6	selection	selection	NN
cord-018387-ci5wx26t	123	7	of	of	IN
cord-018387-ci5wx26t	123	8	T	t	NN
cord-018387-ci5wx26t	123	9	cells	cell	NNS
cord-018387-ci5wx26t	123	10	with	with	IN
cord-018387-ci5wx26t	123	11	an	an	DT
cord-018387-ci5wx26t	123	12	elevated	elevated	JJ
cord-018387-ci5wx26t	123	13	affinity	affinity	NN
cord-018387-ci5wx26t	123	14	for	for	IN
cord-018387-ci5wx26t	123	15	self	self	NN
cord-018387-ci5wx26t	123	16	-	-	HYPH
cord-018387-ci5wx26t	123	17	antigens	antigen	NNS
cord-018387-ci5wx26t	123	18	or	or	CC
cord-018387-ci5wx26t	123	19	latent	latent	JJ
cord-018387-ci5wx26t	123	20	viruses	virus	NNS
cord-018387-ci5wx26t	123	21	,	,	,
cord-018387-ci5wx26t	123	22	which	which	WDT
cord-018387-ci5wx26t	123	23	are	be	VBP
cord-018387-ci5wx26t	123	24	at	at	IN
cord-018387-ci5wx26t	123	25	the	the	DT
cord-018387-ci5wx26t	123	26	same	same	JJ
cord-018387-ci5wx26t	123	27	time	time	NN
cord-018387-ci5wx26t	123	28	also	also	RB
cord-018387-ci5wx26t	123	29	pro	pro	JJ
cord-018387-ci5wx26t	123	30	-	-	JJ
cord-018387-ci5wx26t	123	31	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	123	32	.	.	.
cord-018387-ci5wx26t	124	1	The	the	DT
cord-018387-ci5wx26t	124	2	chronic	chronic	JJ
cord-018387-ci5wx26t	124	3	inflammation	inflammation	NN
cord-018387-ci5wx26t	124	4	additionally	additionally	RB
cord-018387-ci5wx26t	124	5	resulting	result	VBG
cord-018387-ci5wx26t	124	6	in	in	IN
cord-018387-ci5wx26t	124	7	tissue	tissue	NN
cord-018387-ci5wx26t	124	8	injury	injury	NN
cord-018387-ci5wx26t	124	9	and	and	CC
cord-018387-ci5wx26t	124	10	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	124	11	attracts	attract	VBZ
cord-018387-ci5wx26t	124	12	dendritic	dendritic	JJ
cord-018387-ci5wx26t	124	13	cells	cell	NNS
cord-018387-ci5wx26t	124	14	(	(	-LRB-
cord-018387-ci5wx26t	124	15	DC	DC	NNP
cord-018387-ci5wx26t	124	16	)	)	-RRB-
cord-018387-ci5wx26t	124	17	,	,	,
cord-018387-ci5wx26t	124	18	which	which	WDT
cord-018387-ci5wx26t	124	19	in	in	IN
cord-018387-ci5wx26t	124	20	elderly	elderly	JJ
cord-018387-ci5wx26t	124	21	people	people	NNS
cord-018387-ci5wx26t	124	22	have	have	VBP
cord-018387-ci5wx26t	124	23	an	an	DT
cord-018387-ci5wx26t	124	24	impaired	impaired	JJ
cord-018387-ci5wx26t	124	25	ability	ability	NN
cord-018387-ci5wx26t	124	26	to	to	TO
cord-018387-ci5wx26t	124	27	take	take	VB
cord-018387-ci5wx26t	124	28	up	up	RP
cord-018387-ci5wx26t	124	29	apoptotic	apoptotic	JJ
cord-018387-ci5wx26t	124	30	cells	cell	NNS
cord-018387-ci5wx26t	124	31	(	(	-LRB-
cord-018387-ci5wx26t	124	32	Fig	Fig	NNP
cord-018387-ci5wx26t	124	33	.	.	NNP
cord-018387-ci5wx26t	124	34	14.1	14.1	CD
cord-018387-ci5wx26t	124	35	)	)	-RRB-
cord-018387-ci5wx26t	124	36	.	.	.
cord-018387-ci5wx26t	125	1	Instead	instead	RB
cord-018387-ci5wx26t	125	2	,	,	,
cord-018387-ci5wx26t	125	3	they	-PRON-	PRP
cord-018387-ci5wx26t	125	4	induce	induce	VBP
cord-018387-ci5wx26t	125	5	a	a	DT
cord-018387-ci5wx26t	125	6	vicious	vicious	JJ
cord-018387-ci5wx26t	125	7	circle	circle	NN
cord-018387-ci5wx26t	125	8	with	with	IN
cord-018387-ci5wx26t	125	9	a	a	DT
cord-018387-ci5wx26t	125	10	further	further	JJ
cord-018387-ci5wx26t	125	11	pro	pro	JJ
cord-018387-ci5wx26t	125	12	-	-	JJ
cord-018387-ci5wx26t	125	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	125	14	response	response	NN
cord-018387-ci5wx26t	125	15	and	and	CC
cord-018387-ci5wx26t	125	16	increased	increase	VBN
cord-018387-ci5wx26t	125	17	reactivity	reactivity	NN
cord-018387-ci5wx26t	125	18	to	to	IN
cord-018387-ci5wx26t	125	19	self	self	NN
cord-018387-ci5wx26t	125	20	-	-	HYPH
cord-018387-ci5wx26t	125	21	DNA	dna	NN
cord-018387-ci5wx26t	125	22	,	,	,
cord-018387-ci5wx26t	125	23	which	which	WDT
cord-018387-ci5wx26t	125	24	may	may	MD
cord-018387-ci5wx26t	125	25	be	be	VB
cord-018387-ci5wx26t	125	26	more	more	RBR
cord-018387-ci5wx26t	125	27	immunogenic	immunogenic	JJ
cord-018387-ci5wx26t	125	28	in	in	IN
cord-018387-ci5wx26t	125	29	the	the	DT
cord-018387-ci5wx26t	125	30	elderly	elderly	JJ
cord-018387-ci5wx26t	125	31	due	due	IN
cord-018387-ci5wx26t	125	32	to	to	IN
cord-018387-ci5wx26t	125	33	increased	increase	VBN
cord-018387-ci5wx26t	125	34	hypomethylation	hypomethylation	NN
cord-018387-ci5wx26t	125	35	[	[	-LRB-
cord-018387-ci5wx26t	125	36	16	16	CD
cord-018387-ci5wx26t	125	37	]	]	-RRB-
cord-018387-ci5wx26t	125	38	.	.	.
cord-018387-ci5wx26t	126	1	Additionally	additionally	RB
cord-018387-ci5wx26t	126	2	,	,	,
cord-018387-ci5wx26t	126	3	damageassociated	damageassociate	VBN
cord-018387-ci5wx26t	126	4	molecular	molecular	JJ
cord-018387-ci5wx26t	126	5	patterns	pattern	NNS
cord-018387-ci5wx26t	126	6	(	(	-LRB-
cord-018387-ci5wx26t	126	7	DAMPs	damp	NNS
cord-018387-ci5wx26t	126	8	)	)	-RRB-
cord-018387-ci5wx26t	126	9	,	,	,
cord-018387-ci5wx26t	126	10	present	present	JJ
cord-018387-ci5wx26t	126	11	on	on	IN
cord-018387-ci5wx26t	126	12	proteins	protein	NNS
cord-018387-ci5wx26t	126	13	released	release	VBN
cord-018387-ci5wx26t	126	14	during	during	IN
cord-018387-ci5wx26t	126	15	cell	cell	NN
cord-018387-ci5wx26t	126	16	necrosis	necrosis	NN
cord-018387-ci5wx26t	126	17	and	and	CC
cord-018387-ci5wx26t	126	18	promoting	promote	VBG
cord-018387-ci5wx26t	126	19	sterile	sterile	JJ
cord-018387-ci5wx26t	126	20	inflammation	inflammation	NN
cord-018387-ci5wx26t	126	21	,	,	,
cord-018387-ci5wx26t	126	22	also	also	RB
cord-018387-ci5wx26t	126	23	become	become	VBP
cord-018387-ci5wx26t	126	24	more	more	RBR
cord-018387-ci5wx26t	126	25	frequent	frequent	JJ
cord-018387-ci5wx26t	126	26	with	with	IN
cord-018387-ci5wx26t	126	27	advancing	advance	VBG
cord-018387-ci5wx26t	126	28	age	age	NN
cord-018387-ci5wx26t	126	29	[	[	-LRB-
cord-018387-ci5wx26t	126	30	17	17	CD
cord-018387-ci5wx26t	126	31	,	,	,
cord-018387-ci5wx26t	126	32	18	18	CD
cord-018387-ci5wx26t	126	33	]	]	-RRB-
cord-018387-ci5wx26t	126	34	.	.	.
cord-018387-ci5wx26t	127	1	It	-PRON-	PRP
cord-018387-ci5wx26t	127	2	has	have	VBZ
cord-018387-ci5wx26t	127	3	been	be	VBN
cord-018387-ci5wx26t	127	4	suggested	suggest	VBN
cord-018387-ci5wx26t	127	5	that	that	IN
cord-018387-ci5wx26t	127	6	aging	aging	NN
cord-018387-ci5wx26t	127	7	is	be	VBZ
cord-018387-ci5wx26t	127	8	associated	associate	VBN
cord-018387-ci5wx26t	127	9	with	with	IN
cord-018387-ci5wx26t	127	10	chronic	chronic	JJ
cord-018387-ci5wx26t	127	11	innate	innate	JJ
cord-018387-ci5wx26t	127	12	immune	immune	JJ
cord-018387-ci5wx26t	127	13	activation	activation	NN
cord-018387-ci5wx26t	127	14	and	and	CC
cord-018387-ci5wx26t	127	15	significant	significant	JJ
cord-018387-ci5wx26t	127	16	changes	change	NNS
cord-018387-ci5wx26t	127	17	in	in	IN
cord-018387-ci5wx26t	127	18	the	the	DT
cord-018387-ci5wx26t	127	19	functions	function	NNS
cord-018387-ci5wx26t	127	20	of	of	IN
cord-018387-ci5wx26t	127	21	monocytes	monocyte	NNS
cord-018387-ci5wx26t	127	22	and	and	CC
cord-018387-ci5wx26t	127	23	macrophages	macrophage	NNS
cord-018387-ci5wx26t	127	24	,	,	,
cord-018387-ci5wx26t	127	25	which	which	WDT
cord-018387-ci5wx26t	127	26	may	may	MD
cord-018387-ci5wx26t	127	27	have	have	VB
cord-018387-ci5wx26t	127	28	implications	implication	NNS
cord-018387-ci5wx26t	127	29	for	for	IN
cord-018387-ci5wx26t	127	30	increased	increase	VBN
cord-018387-ci5wx26t	127	31	low	low	JJ
cord-018387-ci5wx26t	127	32	-	-	HYPH
cord-018387-ci5wx26t	127	33	grade	grade	NN
cord-018387-ci5wx26t	127	34	chronic	chronic	JJ
cord-018387-ci5wx26t	127	35	inflammation	inflammation	NN
cord-018387-ci5wx26t	127	36	and	and	CC
cord-018387-ci5wx26t	127	37	for	for	IN
cord-018387-ci5wx26t	127	38	the	the	DT
cord-018387-ci5wx26t	127	39	development	development	NN
cord-018387-ci5wx26t	127	40	of	of	IN
cord-018387-ci5wx26t	127	41	age	age	NN
cord-018387-ci5wx26t	127	42	-	-	HYPH
cord-018387-ci5wx26t	127	43	related	relate	VBN
cord-018387-ci5wx26t	127	44	diseases	disease	NNS
cord-018387-ci5wx26t	127	45	[	[	-LRB-
cord-018387-ci5wx26t	127	46	61	61	CD
cord-018387-ci5wx26t	127	47	]	]	-RRB-
cord-018387-ci5wx26t	127	48	.	.	.
cord-018387-ci5wx26t	128	1	Monocytes	monocyte	NNS
cord-018387-ci5wx26t	128	2	are	be	VBP
cord-018387-ci5wx26t	128	3	known	know	VBN
cord-018387-ci5wx26t	128	4	to	to	TO
cord-018387-ci5wx26t	128	5	be	be	VB
cord-018387-ci5wx26t	128	6	mediators	mediator	NNS
cord-018387-ci5wx26t	128	7	of	of	IN
cord-018387-ci5wx26t	128	8	the	the	DT
cord-018387-ci5wx26t	128	9	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	128	10	response	response	NN
cord-018387-ci5wx26t	128	11	and	and	CC
cord-018387-ci5wx26t	128	12	comprise	comprise	VBP
cord-018387-ci5wx26t	128	13	at	at	RB
cord-018387-ci5wx26t	128	14	least	least	RBS
cord-018387-ci5wx26t	128	15	three	three	CD
cord-018387-ci5wx26t	128	16	different	different	JJ
cord-018387-ci5wx26t	128	17	subsets	subset	NNS
cord-018387-ci5wx26t	128	18	,	,	,
cord-018387-ci5wx26t	128	19	namely	namely	RB
cord-018387-ci5wx26t	128	20	,	,	,
cord-018387-ci5wx26t	128	21	classical	classical	JJ
cord-018387-ci5wx26t	128	22	,	,	,
cord-018387-ci5wx26t	128	23	intermediate	intermediate	JJ
cord-018387-ci5wx26t	128	24	,	,	,
cord-018387-ci5wx26t	128	25	and	and	CC
cord-018387-ci5wx26t	128	26	nonclassical	nonclassical	JJ
cord-018387-ci5wx26t	128	27	monocytes	monocyte	NNS
cord-018387-ci5wx26t	128	28	.	.	.
cord-018387-ci5wx26t	129	1	An	an	DT
cord-018387-ci5wx26t	129	2	age	age	NN
cord-018387-ci5wx26t	129	3	-	-	HYPH
cord-018387-ci5wx26t	129	4	related	relate	VBN
cord-018387-ci5wx26t	129	5	increase	increase	NN
cord-018387-ci5wx26t	129	6	in	in	IN
cord-018387-ci5wx26t	129	7	frequencies	frequency	NNS
cord-018387-ci5wx26t	129	8	of	of	IN
cord-018387-ci5wx26t	129	9	intermediate	intermediate	JJ
cord-018387-ci5wx26t	129	10	and	and	CC
cord-018387-ci5wx26t	129	11	nonclassical	nonclassical	JJ
cord-018387-ci5wx26t	129	12	monocytes	monocyte	NNS
cord-018387-ci5wx26t	129	13	has	have	VBZ
cord-018387-ci5wx26t	129	14	been	be	VBN
cord-018387-ci5wx26t	129	15	reported	report	VBN
cord-018387-ci5wx26t	129	16	[	[	-LRB-
cord-018387-ci5wx26t	129	17	62	62	CD
cord-018387-ci5wx26t	129	18	,	,	,
cord-018387-ci5wx26t	129	19	61	61	CD
cord-018387-ci5wx26t	129	20	]	]	-RRB-
cord-018387-ci5wx26t	129	21	.	.	.
cord-018387-ci5wx26t	130	1	Our	-PRON-	PRP$
cord-018387-ci5wx26t	130	2	results	result	NNS
cord-018387-ci5wx26t	130	3	from	from	IN
cord-018387-ci5wx26t	130	4	the	the	DT
cord-018387-ci5wx26t	130	5	Berlin	Berlin	NNP
cord-018387-ci5wx26t	130	6	Aging	Aging	NNP
cord-018387-ci5wx26t	130	7	Study	Study	NNP
cord-018387-ci5wx26t	130	8	II	II	NNP
cord-018387-ci5wx26t	130	9	confirmed	confirm	VBD
cord-018387-ci5wx26t	130	10	these	these	DT
cord-018387-ci5wx26t	130	11	findings	finding	NNS
cord-018387-ci5wx26t	130	12	,	,	,
cord-018387-ci5wx26t	130	13	where	where	WRB
cord-018387-ci5wx26t	130	14	we	-PRON-	PRP
cord-018387-ci5wx26t	130	15	also	also	RB
cord-018387-ci5wx26t	130	16	found	find	VBD
cord-018387-ci5wx26t	130	17	an	an	DT
cord-018387-ci5wx26t	130	18	age	age	NN
cord-018387-ci5wx26t	130	19	-	-	HYPH
cord-018387-ci5wx26t	130	20	related	relate	VBN
cord-018387-ci5wx26t	130	21	increase	increase	NN
cord-018387-ci5wx26t	130	22	in	in	IN
cord-018387-ci5wx26t	130	23	frequencies	frequency	NNS
cord-018387-ci5wx26t	130	24	of	of	IN
cord-018387-ci5wx26t	130	25	intermediate	intermediate	JJ
cord-018387-ci5wx26t	130	26	and	and	CC
cord-018387-ci5wx26t	130	27	nonclassical	nonclassical	JJ
cord-018387-ci5wx26t	130	28	monocytes	monocyte	NNS
cord-018387-ci5wx26t	130	29	[	[	-LRB-
cord-018387-ci5wx26t	130	30	63	63	CD
cord-018387-ci5wx26t	130	31	]	]	-RRB-
cord-018387-ci5wx26t	130	32	.	.	.
cord-018387-ci5wx26t	131	1	Together	together	RB
cord-018387-ci5wx26t	131	2	with	with	IN
cord-018387-ci5wx26t	131	3	age	age	NN
cord-018387-ci5wx26t	131	4	-	-	HYPH
cord-018387-ci5wx26t	131	5	related	relate	VBN
cord-018387-ci5wx26t	131	6	macrophage	macrophage	NN
cord-018387-ci5wx26t	131	7	activation	activation	NN
cord-018387-ci5wx26t	131	8	,	,	,
cord-018387-ci5wx26t	131	9	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	131	10	monocytes	monocyte	NNS
cord-018387-ci5wx26t	131	11	contribute	contribute	VBP
cord-018387-ci5wx26t	131	12	to	to	IN
cord-018387-ci5wx26t	131	13	the	the	DT
cord-018387-ci5wx26t	131	14	subclinical	subclinical	JJ
cord-018387-ci5wx26t	131	15	chronic	chronic	JJ
cord-018387-ci5wx26t	131	16	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	131	17	process	process	NN
cord-018387-ci5wx26t	131	18	[	[	-LRB-
cord-018387-ci5wx26t	131	19	44	44	CD
cord-018387-ci5wx26t	131	20	,	,	,
cord-018387-ci5wx26t	131	21	64	64	CD
cord-018387-ci5wx26t	131	22	,	,	,
cord-018387-ci5wx26t	131	23	65	65	CD
cord-018387-ci5wx26t	131	24	]	]	-RRB-
cord-018387-ci5wx26t	131	25	.	.	.
cord-018387-ci5wx26t	132	1	The	the	DT
cord-018387-ci5wx26t	132	2	immune	immune	JJ
cord-018387-ci5wx26t	132	3	and	and	CC
cord-018387-ci5wx26t	132	4	central	central	JJ
cord-018387-ci5wx26t	132	5	nervous	nervous	JJ
cord-018387-ci5wx26t	132	6	systems	system	NNS
cord-018387-ci5wx26t	132	7	represent	represent	VBP
cord-018387-ci5wx26t	132	8	two	two	CD
cord-018387-ci5wx26t	132	9	adaptive	adaptive	JJ
cord-018387-ci5wx26t	132	10	physiological	physiological	JJ
cord-018387-ci5wx26t	132	11	systems	system	NNS
cord-018387-ci5wx26t	132	12	of	of	IN
cord-018387-ci5wx26t	132	13	the	the	DT
cord-018387-ci5wx26t	132	14	body	body	NN
cord-018387-ci5wx26t	132	15	,	,	,
cord-018387-ci5wx26t	132	16	which	which	WDT
cord-018387-ci5wx26t	132	17	extensively	extensively	RB
cord-018387-ci5wx26t	132	18	communicate	communicate	VBP
cord-018387-ci5wx26t	132	19	with	with	IN
cord-018387-ci5wx26t	132	20	each	each	DT
cord-018387-ci5wx26t	132	21	other	other	JJ
cord-018387-ci5wx26t	132	22	throughout	throughout	IN
cord-018387-ci5wx26t	132	23	the	the	DT
cord-018387-ci5wx26t	132	24	lifespan	lifespan	NN
cord-018387-ci5wx26t	132	25	.	.	.
cord-018387-ci5wx26t	133	1	Given	give	VBN
cord-018387-ci5wx26t	133	2	the	the	DT
cord-018387-ci5wx26t	133	3	multifaceted	multifaceted	JJ
cord-018387-ci5wx26t	133	4	interactions	interaction	NNS
cord-018387-ci5wx26t	133	5	between	between	IN
cord-018387-ci5wx26t	133	6	these	these	DT
cord-018387-ci5wx26t	133	7	systems	system	NNS
cord-018387-ci5wx26t	133	8	and	and	CC
cord-018387-ci5wx26t	133	9	their	-PRON-	PRP$
cord-018387-ci5wx26t	133	10	tight	tight	JJ
cord-018387-ci5wx26t	133	11	interdependency	interdependency	NN
cord-018387-ci5wx26t	133	12	,	,	,
cord-018387-ci5wx26t	133	13	it	-PRON-	PRP
cord-018387-ci5wx26t	133	14	is	be	VBZ
cord-018387-ci5wx26t	133	15	to	to	TO
cord-018387-ci5wx26t	133	16	be	be	VB
cord-018387-ci5wx26t	133	17	expected	expect	VBN
cord-018387-ci5wx26t	133	18	that	that	IN
cord-018387-ci5wx26t	133	19	peripheral	peripheral	JJ
cord-018387-ci5wx26t	133	20	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	133	21	and	and	CC
cord-018387-ci5wx26t	133	22	inflammaging	inflammaging	NN
cord-018387-ci5wx26t	133	23	contribute	contribute	VBP
cord-018387-ci5wx26t	133	24	to	to	IN
cord-018387-ci5wx26t	133	25	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	133	26	.	.	.
cord-018387-ci5wx26t	134	1	Peripheral	peripheral	JJ
cord-018387-ci5wx26t	134	2	low	low	JJ
cord-018387-ci5wx26t	134	3	-	-	HYPH
cord-018387-ci5wx26t	134	4	grade	grade	NN
cord-018387-ci5wx26t	134	5	inflammation	inflammation	NN
cord-018387-ci5wx26t	134	6	may	may	MD
cord-018387-ci5wx26t	134	7	promote	promote	VB
cord-018387-ci5wx26t	134	8	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	134	9	processes	process	NNS
cord-018387-ci5wx26t	134	10	in	in	IN
cord-018387-ci5wx26t	134	11	the	the	DT
cord-018387-ci5wx26t	134	12	aged	aged	JJ
cord-018387-ci5wx26t	134	13	brain	brain	NN
cord-018387-ci5wx26t	134	14	(	(	-LRB-
cord-018387-ci5wx26t	134	15	Fig	Fig	NNP
cord-018387-ci5wx26t	134	16	.	.	.
cord-018387-ci5wx26t	134	17	14	14	CD
cord-018387-ci5wx26t	134	18	.	.	.
cord-018387-ci5wx26t	134	19	2	2	LS
cord-018387-ci5wx26t	134	20	)	)	-RRB-
cord-018387-ci5wx26t	134	21	by	by	IN
cord-018387-ci5wx26t	134	22	modulating	modulate	VBG
cord-018387-ci5wx26t	134	23	glial	glial	JJ
cord-018387-ci5wx26t	134	24	cells	cell	NNS
cord-018387-ci5wx26t	134	25	toward	toward	IN
cord-018387-ci5wx26t	134	26	a	a	DT
cord-018387-ci5wx26t	134	27	more	more	RBR
cord-018387-ci5wx26t	134	28	active	active	JJ
cord-018387-ci5wx26t	134	29	pro	pro	JJ
cord-018387-ci5wx26t	134	30	-	-	JJ
cord-018387-ci5wx26t	134	31	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	134	32	state	state	NN
cord-018387-ci5wx26t	134	33	,	,	,
cord-018387-ci5wx26t	134	34	leading	lead	VBG
cord-018387-ci5wx26t	134	35	to	to	IN
cord-018387-ci5wx26t	134	36	the	the	DT
cord-018387-ci5wx26t	134	37	loss	loss	NN
cord-018387-ci5wx26t	134	38	of	of	IN
cord-018387-ci5wx26t	134	39	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	134	40	function	function	NN
cord-018387-ci5wx26t	134	41	,	,	,
cord-018387-ci5wx26t	134	42	to	to	IN
cord-018387-ci5wx26t	134	43	neuronal	neuronal	JJ
cord-018387-ci5wx26t	134	44	dysfunction	dysfunction	NN
cord-018387-ci5wx26t	134	45	,	,	,
cord-018387-ci5wx26t	134	46	and	and	CC
cord-018387-ci5wx26t	134	47	to	to	IN
cord-018387-ci5wx26t	134	48	the	the	DT
cord-018387-ci5wx26t	134	49	accumulation	accumulation	NN
cord-018387-ci5wx26t	134	50	of	of	IN
cord-018387-ci5wx26t	134	51	brain	brain	NN
cord-018387-ci5wx26t	134	52	tissue	tissue	NN
cord-018387-ci5wx26t	134	53	damage	damage	NN
cord-018387-ci5wx26t	134	54	[	[	-LRB-
cord-018387-ci5wx26t	134	55	65	65	CD
cord-018387-ci5wx26t	134	56	]	]	-RRB-
cord-018387-ci5wx26t	134	57	[	[	-LRB-
cord-018387-ci5wx26t	134	58	66	66	CD
cord-018387-ci5wx26t	134	59	]	]	-RRB-
cord-018387-ci5wx26t	134	60	[	[	-LRB-
cord-018387-ci5wx26t	134	61	67	67	CD
cord-018387-ci5wx26t	134	62	]	]	-RRB-
cord-018387-ci5wx26t	134	63	.	.	.
cord-018387-ci5wx26t	135	1	Systemic	systemic	JJ
cord-018387-ci5wx26t	135	2	inflammation	inflammation	NN
cord-018387-ci5wx26t	135	3	may	may	MD
cord-018387-ci5wx26t	135	4	,	,	,
cord-018387-ci5wx26t	135	5	therefore	therefore	RB
cord-018387-ci5wx26t	135	6	,	,	,
cord-018387-ci5wx26t	135	7	increase	increase	VB
cord-018387-ci5wx26t	135	8	the	the	DT
cord-018387-ci5wx26t	135	9	risk	risk	NN
cord-018387-ci5wx26t	135	10	of	of	IN
cord-018387-ci5wx26t	135	11	developing	develop	VBG
cord-018387-ci5wx26t	135	12	cognitive	cognitive	JJ
cord-018387-ci5wx26t	135	13	impairment	impairment	NN
cord-018387-ci5wx26t	135	14	,	,	,
cord-018387-ci5wx26t	135	15	neurological	neurological	JJ
cord-018387-ci5wx26t	135	16	disorders	disorder	NNS
cord-018387-ci5wx26t	135	17	,	,	,
cord-018387-ci5wx26t	135	18	and	and	CC
cord-018387-ci5wx26t	135	19	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	135	20	[	[	-LRB-
cord-018387-ci5wx26t	135	21	68	68	CD
cord-018387-ci5wx26t	135	22	]	]	-RRB-
cord-018387-ci5wx26t	135	23	[	[	-LRB-
cord-018387-ci5wx26t	135	24	69	69	CD
cord-018387-ci5wx26t	135	25	]	]	-RRB-
cord-018387-ci5wx26t	135	26	[	[	-LRB-
cord-018387-ci5wx26t	135	27	70	70	CD
cord-018387-ci5wx26t	135	28	]	]	-RRB-
cord-018387-ci5wx26t	135	29	.	.	.
cord-018387-ci5wx26t	136	1	In	in	IN
cord-018387-ci5wx26t	136	2	the	the	DT
cord-018387-ci5wx26t	136	3	next	next	JJ
cord-018387-ci5wx26t	136	4	section	section	NN
cord-018387-ci5wx26t	136	5	,	,	,
cord-018387-ci5wx26t	136	6	we	-PRON-	PRP
cord-018387-ci5wx26t	136	7	will	will	MD
cord-018387-ci5wx26t	136	8	have	have	VB
cord-018387-ci5wx26t	136	9	a	a	DT
cord-018387-ci5wx26t	136	10	closer	close	JJR
cord-018387-ci5wx26t	136	11	look	look	NN
cord-018387-ci5wx26t	136	12	at	at	IN
cord-018387-ci5wx26t	136	13	how	how	WRB
cord-018387-ci5wx26t	136	14	inflammaging	inflammaging	NN
cord-018387-ci5wx26t	136	15	may	may	MD
cord-018387-ci5wx26t	136	16	contribute	contribute	VB
cord-018387-ci5wx26t	136	17	to	to	IN
cord-018387-ci5wx26t	136	18	the	the	DT
cord-018387-ci5wx26t	136	19	process	process	NN
cord-018387-ci5wx26t	136	20	of	of	IN
cord-018387-ci5wx26t	136	21	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	136	22	during	during	IN
cord-018387-ci5wx26t	136	23	aging	age	VBG
cord-018387-ci5wx26t	136	24	.	.	.
cord-018387-ci5wx26t	137	1	Human	human	JJ
cord-018387-ci5wx26t	137	2	aging	aging	NN
cord-018387-ci5wx26t	137	3	is	be	VBZ
cord-018387-ci5wx26t	137	4	characterized	characterize	VBN
cord-018387-ci5wx26t	137	5	by	by	IN
cord-018387-ci5wx26t	137	6	an	an	DT
cord-018387-ci5wx26t	137	7	impairment	impairment	NN
cord-018387-ci5wx26t	137	8	of	of	IN
cord-018387-ci5wx26t	137	9	cognitive	cognitive	JJ
cord-018387-ci5wx26t	137	10	abilities	ability	NNS
cord-018387-ci5wx26t	137	11	.	.	.
cord-018387-ci5wx26t	138	1	Although	although	IN
cord-018387-ci5wx26t	138	2	no	no	DT
cord-018387-ci5wx26t	138	3	agreement	agreement	NN
cord-018387-ci5wx26t	138	4	exists	exist	VBZ
cord-018387-ci5wx26t	138	5	on	on	IN
cord-018387-ci5wx26t	138	6	the	the	DT
cord-018387-ci5wx26t	138	7	basic	basic	JJ
cord-018387-ci5wx26t	138	8	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	138	9	involved	involve	VBN
cord-018387-ci5wx26t	138	10	in	in	IN
cord-018387-ci5wx26t	138	11	this	this	DT
cord-018387-ci5wx26t	138	12	process	process	NN
cord-018387-ci5wx26t	138	13	,	,	,
cord-018387-ci5wx26t	138	14	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	138	15	appears	appear	VBZ
cord-018387-ci5wx26t	138	16	to	to	TO
cord-018387-ci5wx26t	138	17	be	be	VB
cord-018387-ci5wx26t	138	18	the	the	DT
cord-018387-ci5wx26t	138	19	main	main	JJ
cord-018387-ci5wx26t	138	20	contributor	contributor	NN
cord-018387-ci5wx26t	138	21	that	that	WDT
cord-018387-ci5wx26t	138	22	links	link	VBZ
cord-018387-ci5wx26t	138	23	together	together	RB
cord-018387-ci5wx26t	138	24	many	many	JJ
cord-018387-ci5wx26t	138	25	factors	factor	NNS
cord-018387-ci5wx26t	138	26	associated	associate	VBN
cord-018387-ci5wx26t	138	27	with	with	IN
cord-018387-ci5wx26t	138	28	cognitive	cognitive	JJ
cord-018387-ci5wx26t	138	29	aging	age	VBG
cord-018387-ci5wx26t	138	30	[	[	-LRB-
cord-018387-ci5wx26t	138	31	65	65	CD
cord-018387-ci5wx26t	138	32	,	,	,
cord-018387-ci5wx26t	138	33	71	71	CD
cord-018387-ci5wx26t	138	34	]	]	-RRB-
cord-018387-ci5wx26t	138	35	.	.	.
cord-018387-ci5wx26t	139	1	As	as	IN
cord-018387-ci5wx26t	139	2	we	-PRON-	PRP
cord-018387-ci5wx26t	139	3	age	age	VBP
cord-018387-ci5wx26t	139	4	,	,	,
cord-018387-ci5wx26t	139	5	we	-PRON-	PRP
cord-018387-ci5wx26t	139	6	experience	experience	VBP
cord-018387-ci5wx26t	139	7	greater	great	JJR
cord-018387-ci5wx26t	139	8	susceptibility	susceptibility	NN
cord-018387-ci5wx26t	139	9	to	to	IN
cord-018387-ci5wx26t	139	10	memory	memory	NN
cord-018387-ci5wx26t	139	11	impairments	impairment	NNS
cord-018387-ci5wx26t	139	12	following	follow	VBG
cord-018387-ci5wx26t	139	13	an	an	DT
cord-018387-ci5wx26t	139	14	immune	immune	JJ
cord-018387-ci5wx26t	139	15	challenge	challenge	NN
cord-018387-ci5wx26t	139	16	that	that	WDT
cord-018387-ci5wx26t	139	17	is	be	VBZ
cord-018387-ci5wx26t	139	18	characterized	characterize	VBN
cord-018387-ci5wx26t	139	19	by	by	IN
cord-018387-ci5wx26t	139	20	an	an	DT
cord-018387-ci5wx26t	139	21	increased	increase	VBN
cord-018387-ci5wx26t	139	22	and	and	CC
cord-018387-ci5wx26t	139	23	prolonged	prolonged	JJ
cord-018387-ci5wx26t	139	24	production	production	NN
cord-018387-ci5wx26t	139	25	of	of	IN
cord-018387-ci5wx26t	139	26	pro	pro	JJ
cord-018387-ci5wx26t	139	27	-	-	JJ
cord-018387-ci5wx26t	139	28	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	139	29	cytokines	cytokine	NNS
cord-018387-ci5wx26t	139	30	in	in	IN
cord-018387-ci5wx26t	139	31	the	the	DT
cord-018387-ci5wx26t	139	32	otherwise	otherwise	RB
cord-018387-ci5wx26t	139	33	healthy	healthy	JJ
cord-018387-ci5wx26t	139	34	aged	aged	JJ
cord-018387-ci5wx26t	139	35	brain	brain	NN
cord-018387-ci5wx26t	139	36	[	[	-LRB-
cord-018387-ci5wx26t	139	37	65	65	CD
cord-018387-ci5wx26t	139	38	,	,	,
cord-018387-ci5wx26t	139	39	72	72	CD
cord-018387-ci5wx26t	139	40	]	]	-RRB-
cord-018387-ci5wx26t	139	41	.	.	.
cord-018387-ci5wx26t	140	1	It	-PRON-	PRP
cord-018387-ci5wx26t	140	2	is	be	VBZ
cord-018387-ci5wx26t	140	3	widely	widely	RB
cord-018387-ci5wx26t	140	4	established	establish	VBN
cord-018387-ci5wx26t	140	5	that	that	IN
cord-018387-ci5wx26t	140	6	both	both	DT
cord-018387-ci5wx26t	140	7	aging	age	VBG
cord-018387-ci5wx26t	140	8	and	and	CC
cord-018387-ci5wx26t	140	9	stress	stress	NN
cord-018387-ci5wx26t	140	10	can	can	MD
cord-018387-ci5wx26t	140	11	affect	affect	VB
cord-018387-ci5wx26t	140	12	the	the	DT
cord-018387-ci5wx26t	140	13	neuroendocrine	neuroendocrine	JJ
cord-018387-ci5wx26t	140	14	system	system	NN
cord-018387-ci5wx26t	140	15	,	,	,
cord-018387-ci5wx26t	140	16	activate	activate	VB
cord-018387-ci5wx26t	140	17	the	the	DT
cord-018387-ci5wx26t	140	18	hypothalamic	hypothalamic	JJ
cord-018387-ci5wx26t	140	19	-	-	HYPH
cord-018387-ci5wx26t	140	20	pituitary	pituitary	NN
cord-018387-ci5wx26t	140	21	-	-	HYPH
cord-018387-ci5wx26t	140	22	adrenal	adrenal	NN
cord-018387-ci5wx26t	140	23	(	(	-LRB-
cord-018387-ci5wx26t	140	24	HPA	HPA	NNP
cord-018387-ci5wx26t	140	25	)	)	-RRB-
cord-018387-ci5wx26t	140	26	axis	axis	NN
cord-018387-ci5wx26t	140	27	to	to	TO
cord-018387-ci5wx26t	140	28	release	release	VB
cord-018387-ci5wx26t	140	29	corticotropin	corticotropin	NNP
cord-018387-ci5wx26t	140	30	-	-	HYPH
cord-018387-ci5wx26t	140	31	releasing	release	VBG
cord-018387-ci5wx26t	140	32	hormone	hormone	NN
cord-018387-ci5wx26t	140	33	(	(	-LRB-
cord-018387-ci5wx26t	140	34	CRH	CRH	NNP
cord-018387-ci5wx26t	140	35	)	)	-RRB-
cord-018387-ci5wx26t	140	36	from	from	IN
cord-018387-ci5wx26t	140	37	the	the	DT
cord-018387-ci5wx26t	140	38	paraventricular	paraventricular	NNP
cord-018387-ci5wx26t	140	39	nucleus	nucleus	NN
cord-018387-ci5wx26t	140	40	of	of	IN
cord-018387-ci5wx26t	140	41	the	the	DT
cord-018387-ci5wx26t	140	42	hypothalamus	hypothalamus	NN
cord-018387-ci5wx26t	140	43	,	,	,
cord-018387-ci5wx26t	140	44	and	and	CC
cord-018387-ci5wx26t	140	45	cause	cause	VB
cord-018387-ci5wx26t	140	46	the	the	DT
cord-018387-ci5wx26t	140	47	anterior	anterior	JJ
cord-018387-ci5wx26t	140	48	pituitary	pituitary	JJ
cord-018387-ci5wx26t	140	49	gland	gland	NN
cord-018387-ci5wx26t	140	50	to	to	IN
cord-018387-ci5wx26t	140	51	secrete	secrete	JJ
cord-018387-ci5wx26t	140	52	adrenocorticotropin	adrenocorticotropin	NNP
cord-018387-ci5wx26t	140	53	(	(	-LRB-
cord-018387-ci5wx26t	140	54	ACTH	ACTH	NNP
cord-018387-ci5wx26t	140	55	)	)	-RRB-
cord-018387-ci5wx26t	141	1	(	(	-LRB-
cord-018387-ci5wx26t	141	2	Fig	Fig	NNP
cord-018387-ci5wx26t	141	3	.	.	.
cord-018387-ci5wx26t	141	4	14.3	14.3	CD
cord-018387-ci5wx26t	141	5	)	)	-RRB-
cord-018387-ci5wx26t	141	6	.	.	.
cord-018387-ci5wx26t	142	1	This	this	DT
cord-018387-ci5wx26t	142	2	,	,	,
cord-018387-ci5wx26t	142	3	in	in	IN
cord-018387-ci5wx26t	142	4	turn	turn	NN
cord-018387-ci5wx26t	142	5	,	,	,
cord-018387-ci5wx26t	142	6	induces	induce	VBZ
cord-018387-ci5wx26t	142	7	the	the	DT
cord-018387-ci5wx26t	142	8	release	release	NN
cord-018387-ci5wx26t	142	9	of	of	IN
cord-018387-ci5wx26t	142	10	glucocorti	glucocorti	NNP
cord-018387-ci5wx26t	142	11	-	-	HYPH
cord-018387-ci5wx26t	142	12	coids	coid	NNS
cord-018387-ci5wx26t	142	13	from	from	IN
cord-018387-ci5wx26t	142	14	the	the	DT
cord-018387-ci5wx26t	142	15	adrenal	adrenal	JJ
cord-018387-ci5wx26t	142	16	gland	gland	NN
cord-018387-ci5wx26t	142	17	into	into	IN
cord-018387-ci5wx26t	142	18	the	the	DT
cord-018387-ci5wx26t	142	19	circulation	circulation	NN
cord-018387-ci5wx26t	142	20	[	[	-LRB-
cord-018387-ci5wx26t	142	21	73	73	CD
cord-018387-ci5wx26t	142	22	]	]	-RRB-
cord-018387-ci5wx26t	142	23	.	.	.
cord-018387-ci5wx26t	143	1	Cortisol	cortisol	NN
cord-018387-ci5wx26t	143	2	affects	affect	VBZ
cord-018387-ci5wx26t	143	3	the	the	DT
cord-018387-ci5wx26t	143	4	immune	immune	JJ
cord-018387-ci5wx26t	143	5	system	system	NN
cord-018387-ci5wx26t	143	6	in	in	IN
cord-018387-ci5wx26t	143	7	different	different	JJ
cord-018387-ci5wx26t	143	8	ways	way	NNS
cord-018387-ci5wx26t	143	9	by	by	IN
cord-018387-ci5wx26t	143	10	regulating	regulate	VBG
cord-018387-ci5wx26t	143	11	the	the	DT
cord-018387-ci5wx26t	143	12	expression	expression	NN
cord-018387-ci5wx26t	143	13	of	of	IN
cord-018387-ci5wx26t	143	14	cytokines	cytokine	NNS
cord-018387-ci5wx26t	143	15	[	[	-LRB-
cord-018387-ci5wx26t	143	16	74	74	CD
cord-018387-ci5wx26t	143	17	]	]	-RRB-
cord-018387-ci5wx26t	143	18	,	,	,
cord-018387-ci5wx26t	143	19	chemokines	chemokine	NNS
cord-018387-ci5wx26t	143	20	,	,	,
cord-018387-ci5wx26t	143	21	and	and	CC
cord-018387-ci5wx26t	143	22	adhesion	adhesion	NN
cord-018387-ci5wx26t	143	23	molecules	molecule	NNS
cord-018387-ci5wx26t	143	24	and	and	CC
cord-018387-ci5wx26t	143	25	by	by	IN
cord-018387-ci5wx26t	143	26	affecting	affect	VBG
cord-018387-ci5wx26t	143	27	immune	immune	JJ
cord-018387-ci5wx26t	143	28	cell	cell	NN
cord-018387-ci5wx26t	143	29	migration	migration	NN
cord-018387-ci5wx26t	143	30	,	,	,
cord-018387-ci5wx26t	143	31	maturation	maturation	NN
cord-018387-ci5wx26t	143	32	,	,	,
cord-018387-ci5wx26t	143	33	and	and	CC
cord-018387-ci5wx26t	143	34	differentiation	differentiation	NN
cord-018387-ci5wx26t	143	35	[	[	-LRB-
cord-018387-ci5wx26t	143	36	65	65	CD
cord-018387-ci5wx26t	143	37	,	,	,
cord-018387-ci5wx26t	143	38	72	72	CD
cord-018387-ci5wx26t	143	39	,	,	,
cord-018387-ci5wx26t	143	40	75	75	CD
cord-018387-ci5wx26t	143	41	]	]	-RRB-
cord-018387-ci5wx26t	143	42	.	.	.
cord-018387-ci5wx26t	144	1	High	high	JJ
cord-018387-ci5wx26t	144	2	levels	level	NNS
cord-018387-ci5wx26t	144	3	of	of	IN
cord-018387-ci5wx26t	144	4	cortisol	cortisol	NN
cord-018387-ci5wx26t	144	5	can	can	MD
cord-018387-ci5wx26t	144	6	negatively	negatively	RB
cord-018387-ci5wx26t	144	7	influence	influence	VB
cord-018387-ci5wx26t	144	8	hippocampal	hippocampal	JJ
cord-018387-ci5wx26t	144	9	neurogenesis	neurogenesis	NN
cord-018387-ci5wx26t	144	10	directly	directly	RB
cord-018387-ci5wx26t	144	11	or	or	CC
cord-018387-ci5wx26t	144	12	indirectly	indirectly	RB
cord-018387-ci5wx26t	144	13	through	through	IN
cord-018387-ci5wx26t	144	14	the	the	DT
cord-018387-ci5wx26t	144	15	regulation	regulation	NN
cord-018387-ci5wx26t	144	16	of	of	IN
cord-018387-ci5wx26t	144	17	the	the	DT
cord-018387-ci5wx26t	144	18	expression	expression	NN
cord-018387-ci5wx26t	144	19	of	of	IN
cord-018387-ci5wx26t	144	20	cytokines	cytokine	NNS
cord-018387-ci5wx26t	144	21	and	and	CC
cord-018387-ci5wx26t	144	22	their	-PRON-	PRP$
cord-018387-ci5wx26t	144	23	receptors	receptor	NNS
cord-018387-ci5wx26t	144	24	on	on	IN
cord-018387-ci5wx26t	144	25	the	the	DT
cord-018387-ci5wx26t	144	26	brain	brain	NN
cord-018387-ci5wx26t	144	27	and	and	CC
cord-018387-ci5wx26t	144	28	immune	immune	JJ
cord-018387-ci5wx26t	144	29	cells	cell	NNS
cord-018387-ci5wx26t	144	30	.	.	.
cord-018387-ci5wx26t	145	1	Recent	recent	JJ
cord-018387-ci5wx26t	145	2	ultrastructural	ultrastructural	JJ
cord-018387-ci5wx26t	145	3	analyses	analysis	NNS
cord-018387-ci5wx26t	145	4	have	have	VBP
cord-018387-ci5wx26t	145	5	uncovered	uncover	VBN
cord-018387-ci5wx26t	145	6	a	a	DT
cord-018387-ci5wx26t	145	7	new	new	JJ
cord-018387-ci5wx26t	145	8	player	player	NN
cord-018387-ci5wx26t	145	9	in	in	IN
cord-018387-ci5wx26t	145	10	the	the	DT
cord-018387-ci5wx26t	145	11	age	age	NN
cord-018387-ci5wx26t	145	12	-	-	HYPH
cord-018387-ci5wx26t	145	13	related	relate	VBN
cord-018387-ci5wx26t	145	14	remodeling	remodeling	NN
cord-018387-ci5wx26t	145	15	of	of	IN
cord-018387-ci5wx26t	145	16	neuronal	neuronal	JJ
cord-018387-ci5wx26t	145	17	circuits	circuit	NNS
cord-018387-ci5wx26t	145	18	,	,	,
cord-018387-ci5wx26t	145	19	especially	especially	RB
cord-018387-ci5wx26t	145	20	at	at	IN
cord-018387-ci5wx26t	145	21	the	the	DT
cord-018387-ci5wx26t	145	22	synapse	synapse	NN
cord-018387-ci5wx26t	145	23	level	level	NN
cord-018387-ci5wx26t	145	24	,	,	,
cord-018387-ci5wx26t	145	25	that	that	RB
cord-018387-ci5wx26t	145	26	is	be	VBZ
cord-018387-ci5wx26t	145	27	rare	rare	JJ
cord-018387-ci5wx26t	145	28	under	under	IN
cord-018387-ci5wx26t	145	29	homeostatic	homeostatic	JJ
cord-018387-ci5wx26t	145	30	conditions	condition	NNS
cord-018387-ci5wx26t	145	31	but	but	CC
cord-018387-ci5wx26t	145	32	becomes	become	VBZ
cord-018387-ci5wx26t	145	33	abundant	abundant	JJ
cord-018387-ci5wx26t	145	34	during	during	IN
cord-018387-ci5wx26t	145	35	aging	age	VBG
cord-018387-ci5wx26t	145	36	,	,	,
cord-018387-ci5wx26t	145	37	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	145	38	,	,	,
cord-018387-ci5wx26t	145	39	and	and	CC
cord-018387-ci5wx26t	145	40	chronic	chronic	JJ
cord-018387-ci5wx26t	145	41	stress	stress	NN
cord-018387-ci5wx26t	145	42	[	[	-LRB-
cord-018387-ci5wx26t	145	43	76	76	CD
cord-018387-ci5wx26t	145	44	]	]	-RRB-
cord-018387-ci5wx26t	145	45	.	.	.
cord-018387-ci5wx26t	146	1	These	these	DT
cord-018387-ci5wx26t	146	2	hyperactive	hyperactive	JJ
cord-018387-ci5wx26t	146	3	"	"	``
cord-018387-ci5wx26t	146	4	dark	dark	JJ
cord-018387-ci5wx26t	146	5	microglia	microglia	NNS
cord-018387-ci5wx26t	146	6	"	"	''
cord-018387-ci5wx26t	146	7	(	(	-LRB-
cord-018387-ci5wx26t	146	8	Fig	Fig	NNP
cord-018387-ci5wx26t	146	9	.	.	.
cord-018387-ci5wx26t	146	10	14	14	CD
cord-018387-ci5wx26t	146	11	.	.	.
cord-018387-ci5wx26t	147	1	3	3	LS
cord-018387-ci5wx26t	147	2	)	)	-RRB-
cord-018387-ci5wx26t	147	3	frequently	frequently	RB
cord-018387-ci5wx26t	147	4	reach	reach	VB
cord-018387-ci5wx26t	147	5	into	into	IN
cord-018387-ci5wx26t	147	6	synaptic	synaptic	JJ
cord-018387-ci5wx26t	147	7	clefts	cleft	NNS
cord-018387-ci5wx26t	147	8	with	with	IN
cord-018387-ci5wx26t	147	9	their	-PRON-	PRP$
cord-018387-ci5wx26t	147	10	highly	highly	RB
cord-018387-ci5wx26t	147	11	ramified	ramified	JJ
cord-018387-ci5wx26t	147	12	and	and	CC
cord-018387-ci5wx26t	147	13	thin	thin	JJ
cord-018387-ci5wx26t	147	14	processes	process	NNS
cord-018387-ci5wx26t	147	15	,	,	,
cord-018387-ci5wx26t	147	16	extensively	extensively	RB
cord-018387-ci5wx26t	147	17	encircle	encircle	VBP
cord-018387-ci5wx26t	147	18	axon	axon	NN
cord-018387-ci5wx26t	147	19	terminals	terminal	NNS
cord-018387-ci5wx26t	147	20	and	and	CC
cord-018387-ci5wx26t	147	21	dendritic	dendritic	JJ
cord-018387-ci5wx26t	147	22	spines	spine	NNS
cord-018387-ci5wx26t	147	23	,	,	,
cord-018387-ci5wx26t	147	24	and	and	CC
cord-018387-ci5wx26t	147	25	engulf	engulf	VB
cord-018387-ci5wx26t	147	26	them	-PRON-	PRP
cord-018387-ci5wx26t	147	27	[	[	-LRB-
cord-018387-ci5wx26t	147	28	76	76	CD
cord-018387-ci5wx26t	147	29	,	,	,
cord-018387-ci5wx26t	147	30	77	77	CD
cord-018387-ci5wx26t	147	31	]	]	-RRB-
cord-018387-ci5wx26t	147	32	.	.	.
cord-018387-ci5wx26t	148	1	Aging	age	VBG
cord-018387-ci5wx26t	148	2	and	and	CC
cord-018387-ci5wx26t	148	3	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	148	4	are	be	VBP
cord-018387-ci5wx26t	148	5	characterized	characterize	VBN
cord-018387-ci5wx26t	148	6	by	by	IN
cord-018387-ci5wx26t	148	7	dysregulated	dysregulate	VBN
cord-018387-ci5wx26t	148	8	interactions	interaction	NNS
cord-018387-ci5wx26t	148	9	with	with	IN
cord-018387-ci5wx26t	148	10	synapses	synapsis	NNS
cord-018387-ci5wx26t	148	11	,	,	,
cord-018387-ci5wx26t	148	12	resulting	result	VBG
cord-018387-ci5wx26t	148	13	in	in	IN
cord-018387-ci5wx26t	148	14	neuronal	neuronal	JJ
cord-018387-ci5wx26t	148	15	loss	loss	NN
cord-018387-ci5wx26t	148	16	,	,	,
cord-018387-ci5wx26t	148	17	which	which	WDT
cord-018387-ci5wx26t	148	18	,	,	,
cord-018387-ci5wx26t	148	19	in	in	IN
cord-018387-ci5wx26t	148	20	turn	turn	NN
cord-018387-ci5wx26t	148	21	,	,	,
cord-018387-ci5wx26t	148	22	represents	represent	VBZ
cord-018387-ci5wx26t	148	23	the	the	DT
cord-018387-ci5wx26t	148	24	best	good	JJS
cord-018387-ci5wx26t	148	25	pathological	pathological	JJ
cord-018387-ci5wx26t	148	26	correlate	correlate	NN
cord-018387-ci5wx26t	148	27	of	of	IN
cord-018387-ci5wx26t	148	28	cognitive	cognitive	JJ
cord-018387-ci5wx26t	148	29	decline	decline	NN
cord-018387-ci5wx26t	148	30	[	[	-LRB-
cord-018387-ci5wx26t	148	31	77	77	CD
cord-018387-ci5wx26t	148	32	]	]	-RRB-
cord-018387-ci5wx26t	148	33	.	.	.
cord-018387-ci5wx26t	149	1	These	these	DT
cord-018387-ci5wx26t	149	2	conditions	condition	NNS
cord-018387-ci5wx26t	149	3	can	can	MD
cord-018387-ci5wx26t	149	4	sensitize	sensitize	VB
cord-018387-ci5wx26t	149	5	the	the	DT
cord-018387-ci5wx26t	149	6	aged	aged	JJ
cord-018387-ci5wx26t	149	7	brain	brain	NN
cord-018387-ci5wx26t	149	8	to	to	TO
cord-018387-ci5wx26t	149	9	produce	produce	VB
cord-018387-ci5wx26t	149	10	an	an	DT
cord-018387-ci5wx26t	149	11	exaggerated	exaggerated	JJ
cord-018387-ci5wx26t	149	12	response	response	NN
cord-018387-ci5wx26t	149	13	following	follow	VBG
cord-018387-ci5wx26t	149	14	exposure	exposure	NN
cord-018387-ci5wx26t	149	15	to	to	IN
cord-018387-ci5wx26t	149	16	a	a	DT
cord-018387-ci5wx26t	149	17	stressor	stressor	NN
cord-018387-ci5wx26t	149	18	or	or	CC
cord-018387-ci5wx26t	149	19	to	to	IN
cord-018387-ci5wx26t	149	20	the	the	DT
cord-018387-ci5wx26t	149	21	presence	presence	NN
cord-018387-ci5wx26t	149	22	of	of	IN
cord-018387-ci5wx26t	149	23	an	an	DT
cord-018387-ci5wx26t	149	24	immune	immune	JJ
cord-018387-ci5wx26t	149	25	stimulus	stimulus	NN
cord-018387-ci5wx26t	149	26	in	in	IN
cord-018387-ci5wx26t	149	27	the	the	DT
cord-018387-ci5wx26t	149	28	periphery	periphery	NN
cord-018387-ci5wx26t	149	29	[	[	-LRB-
cord-018387-ci5wx26t	149	30	78	78	CD
cord-018387-ci5wx26t	149	31	]	]	-RRB-
cord-018387-ci5wx26t	149	32	.	.	.
cord-018387-ci5wx26t	150	1	Altered	alter	VBN
cord-018387-ci5wx26t	150	2	microglia	microglia	NN
cord-018387-ci5wx26t	150	3	profiles	profile	NNS
cord-018387-ci5wx26t	150	4	together	together	RB
cord-018387-ci5wx26t	150	5	with	with	IN
cord-018387-ci5wx26t	150	6	impairments	impairment	NNS
cord-018387-ci5wx26t	150	7	in	in	IN
cord-018387-ci5wx26t	150	8	key	key	JJ
cord-018387-ci5wx26t	150	9	regulatory	regulatory	JJ
cord-018387-ci5wx26t	150	10	systems	system	NNS
cord-018387-ci5wx26t	150	11	can	can	MD
cord-018387-ci5wx26t	150	12	lead	lead	VB
cord-018387-ci5wx26t	150	13	to	to	IN
cord-018387-ci5wx26t	150	14	prolonged	prolonged	JJ
cord-018387-ci5wx26t	150	15	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	150	16	and	and	CC
cord-018387-ci5wx26t	150	17	age	age	NN
cord-018387-ci5wx26t	150	18	-	-	HYPH
cord-018387-ci5wx26t	150	19	related	relate	VBN
cord-018387-ci5wx26t	150	20	neurobehavioral	neurobehavioral	JJ
cord-018387-ci5wx26t	150	21	complications	complication	NNS
cord-018387-ci5wx26t	150	22	[	[	-LRB-
cord-018387-ci5wx26t	150	23	65	65	CD
cord-018387-ci5wx26t	150	24	,	,	,
cord-018387-ci5wx26t	150	25	79	79	CD
cord-018387-ci5wx26t	150	26	]	]	-RRB-
cord-018387-ci5wx26t	150	27	.	.	.
cord-018387-ci5wx26t	151	1	On	on	IN
cord-018387-ci5wx26t	151	2	the	the	DT
cord-018387-ci5wx26t	151	3	systemic	systemic	JJ
cord-018387-ci5wx26t	151	4	level	level	NN
cord-018387-ci5wx26t	151	5	,	,	,
cord-018387-ci5wx26t	151	6	peripheral	peripheral	JJ
cord-018387-ci5wx26t	151	7	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	151	8	and	and	CC
cord-018387-ci5wx26t	151	9	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	151	10	lead	lead	NN
cord-018387-ci5wx26t	151	11	to	to	IN
cord-018387-ci5wx26t	151	12	age	age	NN
cord-018387-ci5wx26t	151	13	-	-	HYPH
cord-018387-ci5wx26t	151	14	related	relate	VBN
cord-018387-ci5wx26t	151	15	changes	change	NNS
cord-018387-ci5wx26t	151	16	in	in	IN
cord-018387-ci5wx26t	151	17	the	the	DT
cord-018387-ci5wx26t	151	18	blood	blood	NN
cord-018387-ci5wx26t	152	1	(	(	-LRB-
cord-018387-ci5wx26t	152	2	Fig	Fig	NNP
cord-018387-ci5wx26t	152	3	.	.	.
cord-018387-ci5wx26t	153	1	14	14	CD
cord-018387-ci5wx26t	153	2	.	.	.
cord-018387-ci5wx26t	153	3	3	3	LS
cord-018387-ci5wx26t	153	4	)	)	-RRB-
cord-018387-ci5wx26t	153	5	[	[	-LRB-
cord-018387-ci5wx26t	153	6	65	65	CD
cord-018387-ci5wx26t	153	7	]	]	-RRB-
cord-018387-ci5wx26t	153	8	.	.	.
cord-018387-ci5wx26t	154	1	Chronic	chronic	JJ
cord-018387-ci5wx26t	154	2	exposure	exposure	NN
cord-018387-ci5wx26t	154	3	to	to	IN
cord-018387-ci5wx26t	154	4	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	154	5	mediators	mediator	NNS
cord-018387-ci5wx26t	154	6	may	may	MD
cord-018387-ci5wx26t	154	7	disrupt	disrupt	VB
cord-018387-ci5wx26t	154	8	the	the	DT
cord-018387-ci5wx26t	154	9	endothelial	endothelial	JJ
cord-018387-ci5wx26t	154	10	barrier	barrier	NN
cord-018387-ci5wx26t	154	11	and	and	CC
cord-018387-ci5wx26t	154	12	allow	allow	VB
cord-018387-ci5wx26t	154	13	for	for	IN
cord-018387-ci5wx26t	154	14	the	the	DT
cord-018387-ci5wx26t	154	15	transfer	transfer	NN
cord-018387-ci5wx26t	154	16	of	of	IN
cord-018387-ci5wx26t	154	17	immune	immune	JJ
cord-018387-ci5wx26t	154	18	cells	cell	NNS
cord-018387-ci5wx26t	154	19	and	and	CC
cord-018387-ci5wx26t	154	20	numerous	numerous	JJ
cord-018387-ci5wx26t	154	21	pro	pro	JJ
cord-018387-ci5wx26t	154	22	-	-	JJ
cord-018387-ci5wx26t	154	23	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	154	24	cytokines	cytokine	NNS
cord-018387-ci5wx26t	154	25	into	into	IN
cord-018387-ci5wx26t	154	26	the	the	DT
cord-018387-ci5wx26t	154	27	brain	brain	NN
cord-018387-ci5wx26t	154	28	parenchyma	parenchyma	NN
cord-018387-ci5wx26t	154	29	that	that	WDT
cord-018387-ci5wx26t	154	30	,	,	,
cord-018387-ci5wx26t	154	31	in	in	IN
cord-018387-ci5wx26t	154	32	turn	turn	NN
cord-018387-ci5wx26t	154	33	,	,	,
cord-018387-ci5wx26t	154	34	can	can	MD
cord-018387-ci5wx26t	154	35	modulate	modulate	VB
cord-018387-ci5wx26t	154	36	microglial	microglial	JJ
cord-018387-ci5wx26t	154	37	phenotype	phenotype	NN
cord-018387-ci5wx26t	154	38	and	and	CC
cord-018387-ci5wx26t	154	39	reactivity	reactivity	NN
cord-018387-ci5wx26t	154	40	and	and	CC
cord-018387-ci5wx26t	154	41	drive	drive	VB
cord-018387-ci5wx26t	154	42	low	low	JJ
cord-018387-ci5wx26t	154	43	-	-	HYPH
cord-018387-ci5wx26t	154	44	grade	grade	NN
cord-018387-ci5wx26t	154	45	brain	brain	NN
cord-018387-ci5wx26t	154	46	inflammation	inflammation	NN
cord-018387-ci5wx26t	154	47	.	.	.
cord-018387-ci5wx26t	155	1	Brain	brain	NN
cord-018387-ci5wx26t	155	2	cells	cell	NNS
cord-018387-ci5wx26t	155	3	,	,	,
cord-018387-ci5wx26t	155	4	such	such	JJ
cord-018387-ci5wx26t	155	5	as	as	IN
cord-018387-ci5wx26t	155	6	microglia	microglia	NN
cord-018387-ci5wx26t	155	7	,	,	,
cord-018387-ci5wx26t	155	8	astrocytes	astrocyte	NNS
cord-018387-ci5wx26t	155	9	,	,	,
cord-018387-ci5wx26t	155	10	and	and	CC
cord-018387-ci5wx26t	155	11	neurons	neuron	NNS
cord-018387-ci5wx26t	155	12	,	,	,
cord-018387-ci5wx26t	155	13	as	as	RB
cord-018387-ci5wx26t	155	14	well	well	RB
cord-018387-ci5wx26t	155	15	as	as	IN
cord-018387-ci5wx26t	155	16	peripheral	peripheral	JJ
cord-018387-ci5wx26t	155	17	immune	immune	JJ
cord-018387-ci5wx26t	155	18	cells	cell	NNS
cord-018387-ci5wx26t	155	19	,	,	,
cord-018387-ci5wx26t	155	20	such	such	JJ
cord-018387-ci5wx26t	155	21	as	as	IN
cord-018387-ci5wx26t	155	22	T	T	NNP
cord-018387-ci5wx26t	155	23	cells	cell	NNS
cord-018387-ci5wx26t	155	24	,	,	,
cord-018387-ci5wx26t	155	25	monocytes	monocyte	NNS
cord-018387-ci5wx26t	155	26	,	,	,
cord-018387-ci5wx26t	155	27	and	and	CC
cord-018387-ci5wx26t	155	28	macrophages	macrophage	NNS
cord-018387-ci5wx26t	155	29	,	,	,
cord-018387-ci5wx26t	155	30	participate	participate	VB
cord-018387-ci5wx26t	155	31	in	in	IN
cord-018387-ci5wx26t	155	32	inflammation	inflammation	NN
cord-018387-ci5wx26t	155	33	(	(	-LRB-
cord-018387-ci5wx26t	155	34	Fig	Fig	NNP
cord-018387-ci5wx26t	155	35	.	.	.
cord-018387-ci5wx26t	155	36	14.3	14.3	CD
cord-018387-ci5wx26t	155	37	)	)	-RRB-
cord-018387-ci5wx26t	155	38	.	.	.
cord-018387-ci5wx26t	156	1	It	-PRON-	PRP
cord-018387-ci5wx26t	156	2	would	would	MD
cord-018387-ci5wx26t	156	3	provide	provide	VB
cord-018387-ci5wx26t	156	4	an	an	DT
cord-018387-ci5wx26t	156	5	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	156	6	milieu	milieu	NN
cord-018387-ci5wx26t	156	7	that	that	WDT
cord-018387-ci5wx26t	156	8	is	be	VBZ
cord-018387-ci5wx26t	156	9	populated	populate	VBN
cord-018387-ci5wx26t	156	10	by	by	IN
cord-018387-ci5wx26t	156	11	all	all	PDT
cord-018387-ci5wx26t	156	12	these	these	DT
cord-018387-ci5wx26t	156	13	resident	resident	JJ
cord-018387-ci5wx26t	156	14	and	and	CC
cord-018387-ci5wx26t	156	15	additional	additional	JJ
cord-018387-ci5wx26t	156	16	infiltrating	infiltrate	VBG
cord-018387-ci5wx26t	156	17	immune	immune	JJ
cord-018387-ci5wx26t	156	18	cells	cell	NNS
cord-018387-ci5wx26t	156	19	that	that	WDT
cord-018387-ci5wx26t	156	20	participate	participate	VBP
cord-018387-ci5wx26t	156	21	in	in	IN
cord-018387-ci5wx26t	156	22	a	a	DT
cord-018387-ci5wx26t	156	23	complex	complex	JJ
cord-018387-ci5wx26t	156	24	inter-	inter-	NN
cord-018387-ci5wx26t	157	1	Fig	fig	NN
cord-018387-ci5wx26t	157	2	.	.	.
cord-018387-ci5wx26t	157	3	14.3	14.3	CD
cord-018387-ci5wx26t	158	1	The	the	DT
cord-018387-ci5wx26t	158	2	aging	age	VBG
cord-018387-ci5wx26t	158	3	brain	brain	NN
cord-018387-ci5wx26t	158	4	and	and	CC
cord-018387-ci5wx26t	158	5	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	158	6	.	.	.
cord-018387-ci5wx26t	159	1	Aging	age	VBG
cord-018387-ci5wx26t	159	2	and	and	CC
cord-018387-ci5wx26t	159	3	stress	stress	NN
cord-018387-ci5wx26t	159	4	activate	activate	VBP
cord-018387-ci5wx26t	159	5	the	the	DT
cord-018387-ci5wx26t	159	6	HPA	HPA	NNP
cord-018387-ci5wx26t	159	7	axis	axis	NN
cord-018387-ci5wx26t	159	8	to	to	TO
cord-018387-ci5wx26t	159	9	release	release	VB
cord-018387-ci5wx26t	159	10	CRH	crh	NN
cord-018387-ci5wx26t	159	11	from	from	IN
cord-018387-ci5wx26t	159	12	the	the	DT
cord-018387-ci5wx26t	159	13	paraventricular	paraventricular	NNP
cord-018387-ci5wx26t	159	14	nucleus	nucleus	NN
cord-018387-ci5wx26t	159	15	of	of	IN
cord-018387-ci5wx26t	159	16	the	the	DT
cord-018387-ci5wx26t	159	17	hypothalamus	hypothalamus	NN
cord-018387-ci5wx26t	159	18	and	and	CC
cord-018387-ci5wx26t	159	19	cause	cause	VB
cord-018387-ci5wx26t	159	20	the	the	DT
cord-018387-ci5wx26t	159	21	anterior	anterior	JJ
cord-018387-ci5wx26t	159	22	pituitary	pituitary	JJ
cord-018387-ci5wx26t	159	23	gland	gland	NN
cord-018387-ci5wx26t	159	24	to	to	TO
cord-018387-ci5wx26t	159	25	secrete	secrete	VB
cord-018387-ci5wx26t	159	26	ACTH	ACTH	NNP
cord-018387-ci5wx26t	159	27	.	.	.
cord-018387-ci5wx26t	160	1	This	this	DT
cord-018387-ci5wx26t	160	2	,	,	,
cord-018387-ci5wx26t	160	3	in	in	IN
cord-018387-ci5wx26t	160	4	turn	turn	NN
cord-018387-ci5wx26t	160	5	,	,	,
cord-018387-ci5wx26t	160	6	induces	induce	VBZ
cord-018387-ci5wx26t	160	7	the	the	DT
cord-018387-ci5wx26t	160	8	release	release	NN
cord-018387-ci5wx26t	160	9	of	of	IN
cord-018387-ci5wx26t	160	10	glucocorticoids	glucocorticoid	NNS
cord-018387-ci5wx26t	160	11	from	from	IN
cord-018387-ci5wx26t	160	12	the	the	DT
cord-018387-ci5wx26t	160	13	adrenal	adrenal	JJ
cord-018387-ci5wx26t	160	14	gland	gland	NN
cord-018387-ci5wx26t	160	15	into	into	IN
cord-018387-ci5wx26t	160	16	the	the	DT
cord-018387-ci5wx26t	160	17	circulation	circulation	NN
cord-018387-ci5wx26t	160	18	.	.	.
cord-018387-ci5wx26t	161	1	High	high	JJ
cord-018387-ci5wx26t	161	2	levels	level	NNS
cord-018387-ci5wx26t	161	3	of	of	IN
cord-018387-ci5wx26t	161	4	cortisol	cortisol	NN
cord-018387-ci5wx26t	161	5	can	can	MD
cord-018387-ci5wx26t	161	6	negatively	negatively	RB
cord-018387-ci5wx26t	161	7	influence	influence	VB
cord-018387-ci5wx26t	161	8	hippocampal	hippocampal	JJ
cord-018387-ci5wx26t	161	9	neurogenesis	neurogenesis	NN
cord-018387-ci5wx26t	161	10	directly	directly	RB
cord-018387-ci5wx26t	161	11	or	or	CC
cord-018387-ci5wx26t	161	12	indirectly	indirectly	RB
cord-018387-ci5wx26t	161	13	through	through	IN
cord-018387-ci5wx26t	161	14	the	the	DT
cord-018387-ci5wx26t	161	15	regulation	regulation	NN
cord-018387-ci5wx26t	161	16	of	of	IN
cord-018387-ci5wx26t	161	17	an	an	DT
cord-018387-ci5wx26t	161	18	expression	expression	NN
cord-018387-ci5wx26t	161	19	of	of	IN
cord-018387-ci5wx26t	161	20	cytokines	cytokine	NNS
cord-018387-ci5wx26t	161	21	and	and	CC
cord-018387-ci5wx26t	161	22	their	-PRON-	PRP$
cord-018387-ci5wx26t	161	23	receptors	receptor	NNS
cord-018387-ci5wx26t	161	24	on	on	IN
cord-018387-ci5wx26t	161	25	the	the	DT
cord-018387-ci5wx26t	161	26	brain	brain	NN
cord-018387-ci5wx26t	161	27	and	and	CC
cord-018387-ci5wx26t	161	28	immune	immune	JJ
cord-018387-ci5wx26t	161	29	cells	cell	NNS
cord-018387-ci5wx26t	161	30	.	.	.
cord-018387-ci5wx26t	162	1	Peripheral	peripheral	JJ
cord-018387-ci5wx26t	162	2	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	162	3	and	and	CC
cord-018387-ci5wx26t	162	4	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	162	5	lead	lead	NN
cord-018387-ci5wx26t	162	6	to	to	IN
cord-018387-ci5wx26t	162	7	age	age	NN
cord-018387-ci5wx26t	162	8	-	-	HYPH
cord-018387-ci5wx26t	162	9	related	relate	VBN
cord-018387-ci5wx26t	162	10	changes	change	NNS
cord-018387-ci5wx26t	162	11	in	in	IN
cord-018387-ci5wx26t	162	12	the	the	DT
cord-018387-ci5wx26t	162	13	blood	blood	NN
cord-018387-ci5wx26t	162	14	.	.	.
cord-018387-ci5wx26t	163	1	Chronic	chronic	JJ
cord-018387-ci5wx26t	163	2	exposure	exposure	NN
cord-018387-ci5wx26t	163	3	to	to	IN
cord-018387-ci5wx26t	163	4	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	163	5	mediators	mediator	NNS
cord-018387-ci5wx26t	163	6	may	may	MD
cord-018387-ci5wx26t	163	7	disrupt	disrupt	VB
cord-018387-ci5wx26t	163	8	the	the	DT
cord-018387-ci5wx26t	163	9	endothelial	endothelial	JJ
cord-018387-ci5wx26t	163	10	barrier	barrier	NN
cord-018387-ci5wx26t	163	11	and	and	CC
cord-018387-ci5wx26t	163	12	allow	allow	VB
cord-018387-ci5wx26t	163	13	for	for	IN
cord-018387-ci5wx26t	163	14	the	the	DT
cord-018387-ci5wx26t	163	15	transfer	transfer	NN
cord-018387-ci5wx26t	163	16	of	of	IN
cord-018387-ci5wx26t	163	17	immune	immune	JJ
cord-018387-ci5wx26t	163	18	cells	cell	NNS
cord-018387-ci5wx26t	163	19	and	and	CC
cord-018387-ci5wx26t	163	20	numerous	numerous	JJ
cord-018387-ci5wx26t	163	21	pro	pro	JJ
cord-018387-ci5wx26t	163	22	-	-	JJ
cord-018387-ci5wx26t	163	23	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	163	24	cytokines	cytokine	NNS
cord-018387-ci5wx26t	163	25	into	into	IN
cord-018387-ci5wx26t	163	26	the	the	DT
cord-018387-ci5wx26t	163	27	brain	brain	NN
cord-018387-ci5wx26t	163	28	parenchyma	parenchyma	NN
cord-018387-ci5wx26t	163	29	that	that	WDT
cord-018387-ci5wx26t	163	30	,	,	,
cord-018387-ci5wx26t	163	31	in	in	IN
cord-018387-ci5wx26t	163	32	turn	turn	NN
cord-018387-ci5wx26t	163	33	,	,	,
cord-018387-ci5wx26t	163	34	can	can	MD
cord-018387-ci5wx26t	163	35	modulate	modulate	VB
cord-018387-ci5wx26t	163	36	microglial	microglial	JJ
cord-018387-ci5wx26t	163	37	phenotype	phenotype	NN
cord-018387-ci5wx26t	163	38	and	and	CC
cord-018387-ci5wx26t	163	39	reactivity	reactivity	NN
cord-018387-ci5wx26t	163	40	and	and	CC
cord-018387-ci5wx26t	163	41	drive	drive	VB
cord-018387-ci5wx26t	163	42	low	low	JJ
cord-018387-ci5wx26t	163	43	-	-	HYPH
cord-018387-ci5wx26t	163	44	grade	grade	NN
cord-018387-ci5wx26t	163	45	brain	brain	NN
cord-018387-ci5wx26t	163	46	inflammation	inflammation	NN
cord-018387-ci5wx26t	163	47	.	.	.
cord-018387-ci5wx26t	164	1	Activated	activate	VBN
cord-018387-ci5wx26t	164	2	microglia	microglia	NNS
cord-018387-ci5wx26t	164	3	and	and	CC
cord-018387-ci5wx26t	164	4	astrocytes	astrocyte	NNS
cord-018387-ci5wx26t	164	5	change	change	VBP
cord-018387-ci5wx26t	164	6	their	-PRON-	PRP$
cord-018387-ci5wx26t	164	7	morphology	morphology	NN
cord-018387-ci5wx26t	164	8	and	and	CC
cord-018387-ci5wx26t	164	9	function	function	VB
cord-018387-ci5wx26t	164	10	and	and	CC
cord-018387-ci5wx26t	164	11	produce	produce	VB
cord-018387-ci5wx26t	164	12	pro	pro	JJ
cord-018387-ci5wx26t	164	13	-	-	JJ
cord-018387-ci5wx26t	164	14	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	164	15	cytokines	cytokine	NNS
cord-018387-ci5wx26t	164	16	,	,	,
cord-018387-ci5wx26t	164	17	such	such	JJ
cord-018387-ci5wx26t	164	18	as	as	IN
cord-018387-ci5wx26t	164	19	IL-1	IL-1	NNP
cord-018387-ci5wx26t	164	20	β	β	NNP
cord-018387-ci5wx26t	164	21	,	,	,
cord-018387-ci5wx26t	164	22	IL-6	IL-6	NNP
cord-018387-ci5wx26t	164	23	,	,	,
cord-018387-ci5wx26t	164	24	and	and	CC
cord-018387-ci5wx26t	164	25	TNF	TNF	NNP
cord-018387-ci5wx26t	164	26	.	.	.
cord-018387-ci5wx26t	165	1	Macrophages	macrophage	NNS
cord-018387-ci5wx26t	165	2	change	change	VBP
cord-018387-ci5wx26t	165	3	their	-PRON-	PRP$
cord-018387-ci5wx26t	165	4	protective	protective	JJ
cord-018387-ci5wx26t	165	5	M2-phenotype	M2-phenotype	NNS
cord-018387-ci5wx26t	165	6	to	to	IN
cord-018387-ci5wx26t	165	7	the	the	DT
cord-018387-ci5wx26t	165	8	pro	pro	JJ
cord-018387-ci5wx26t	165	9	-	-	JJ
cord-018387-ci5wx26t	165	10	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	165	11	M1-phenotype	M1-phenotype	NNS
cord-018387-ci5wx26t	165	12	,	,	,
cord-018387-ci5wx26t	165	13	thus	thus	RB
cord-018387-ci5wx26t	165	14	contributing	contribute	VBG
cord-018387-ci5wx26t	165	15	to	to	IN
cord-018387-ci5wx26t	165	16	further	further	JJ
cord-018387-ci5wx26t	165	17	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	165	18	.	.	.
cord-018387-ci5wx26t	166	1	This	this	DT
cord-018387-ci5wx26t	166	2	overproduction	overproduction	NN
cord-018387-ci5wx26t	166	3	of	of	IN
cord-018387-ci5wx26t	166	4	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	166	5	mediators	mediator	NNS
cord-018387-ci5wx26t	166	6	disrupts	disrupt	VBZ
cord-018387-ci5wx26t	166	7	the	the	DT
cord-018387-ci5wx26t	166	8	delicate	delicate	JJ
cord-018387-ci5wx26t	166	9	balance	balance	NN
cord-018387-ci5wx26t	166	10	needed	need	VBN
cord-018387-ci5wx26t	166	11	for	for	IN
cord-018387-ci5wx26t	166	12	LTP	LTP	NNP
cord-018387-ci5wx26t	166	13	induction	induction	NN
cord-018387-ci5wx26t	166	14	,	,	,
cord-018387-ci5wx26t	166	15	impairs	impair	VBZ
cord-018387-ci5wx26t	166	16	synaptic	synaptic	JJ
cord-018387-ci5wx26t	166	17	plasticity	plasticity	NN
cord-018387-ci5wx26t	166	18	,	,	,
cord-018387-ci5wx26t	166	19	and	and	CC
cord-018387-ci5wx26t	166	20	reduces	reduce	VBZ
cord-018387-ci5wx26t	166	21	the	the	DT
cord-018387-ci5wx26t	166	22	production	production	NN
cord-018387-ci5wx26t	166	23	of	of	IN
cord-018387-ci5wx26t	166	24	BDNF	BDNF	NNP
cord-018387-ci5wx26t	166	25	and	and	CC
cord-018387-ci5wx26t	166	26	IGF-1	IGF-1	NNP
cord-018387-ci5wx26t	166	27	,	,	,
cord-018387-ci5wx26t	166	28	thus	thus	RB
cord-018387-ci5wx26t	166	29	having	have	VBG
cord-018387-ci5wx26t	166	30	detrimental	detrimental	JJ
cord-018387-ci5wx26t	166	31	consequences	consequence	NNS
cord-018387-ci5wx26t	166	32	for	for	IN
cord-018387-ci5wx26t	166	33	neural	neural	JJ
cord-018387-ci5wx26t	166	34	precursor	precursor	NN
cord-018387-ci5wx26t	166	35	cells	cell	NNS
cord-018387-ci5wx26t	166	36	as	as	RB
cord-018387-ci5wx26t	166	37	well	well	RB
cord-018387-ci5wx26t	166	38	as	as	IN
cord-018387-ci5wx26t	166	39	for	for	IN
cord-018387-ci5wx26t	166	40	the	the	DT
cord-018387-ci5wx26t	166	41	normal	normal	JJ
cord-018387-ci5wx26t	166	42	neuronal	neuronal	JJ
cord-018387-ci5wx26t	166	43	functioning	functioning	NN
cord-018387-ci5wx26t	166	44	.	.	.
cord-018387-ci5wx26t	167	1	HPA	HPA	NNP
cord-018387-ci5wx26t	167	2	,	,	,
cord-018387-ci5wx26t	167	3	hypothalamic	hypothalamic	JJ
cord-018387-ci5wx26t	167	4	-	-	HYPH
cord-018387-ci5wx26t	167	5	pituitary	pituitary	NN
cord-018387-ci5wx26t	167	6	-	-	HYPH
cord-018387-ci5wx26t	167	7	adrenal	adrenal	NN
cord-018387-ci5wx26t	167	8	axis	axis	NN
cord-018387-ci5wx26t	167	9	;	;	:
cord-018387-ci5wx26t	167	10	CRH	CRH	NNP
cord-018387-ci5wx26t	167	11	,	,	,
cord-018387-ci5wx26t	167	12	corticotropin	corticotropin	NNP
cord-018387-ci5wx26t	167	13	-	-	HYPH
cord-018387-ci5wx26t	167	14	releasing	release	VBG
cord-018387-ci5wx26t	167	15	hormone	hormone	NN
cord-018387-ci5wx26t	167	16	;	;	:
cord-018387-ci5wx26t	167	17	ACTH	ACTH	NNP
cord-018387-ci5wx26t	167	18	,	,	,
cord-018387-ci5wx26t	167	19	adrenocorticotropin	adrenocorticotropin	NNP
cord-018387-ci5wx26t	167	20	;	;	:
cord-018387-ci5wx26t	167	21	IL	IL	NNP
cord-018387-ci5wx26t	167	22	,	,	,
cord-018387-ci5wx26t	167	23	interleukin	interleukin	NN
cord-018387-ci5wx26t	167	24	;	;	:
cord-018387-ci5wx26t	167	25	IFN	IFN	NNP
cord-018387-ci5wx26t	167	26	,	,	,
cord-018387-ci5wx26t	167	27	interferon	interferon	NN
cord-018387-ci5wx26t	167	28	;	;	:
cord-018387-ci5wx26t	167	29	TNF	TNF	NNP
cord-018387-ci5wx26t	167	30	,	,	,
cord-018387-ci5wx26t	167	31	tumor	tumor	NN
cord-018387-ci5wx26t	167	32	necrosis	necrosis	NN
cord-018387-ci5wx26t	167	33	factor	factor	NN
cord-018387-ci5wx26t	167	34	;	;	:
cord-018387-ci5wx26t	167	35	LTP	LTP	NNP
cord-018387-ci5wx26t	167	36	,	,	,
cord-018387-ci5wx26t	167	37	long	long	JJ
cord-018387-ci5wx26t	167	38	-	-	HYPH
cord-018387-ci5wx26t	167	39	term	term	NN
cord-018387-ci5wx26t	167	40	memory	memory	NN
cord-018387-ci5wx26t	167	41	potentiation	potentiation	NN
cord-018387-ci5wx26t	167	42	;	;	:
cord-018387-ci5wx26t	167	43	BDNF	BDNF	NNP
cord-018387-ci5wx26t	167	44	,	,	,
cord-018387-ci5wx26t	167	45	brainderived	brainderived	JJ
cord-018387-ci5wx26t	167	46	neurotrophic	neurotrophic	NN
cord-018387-ci5wx26t	167	47	factor	factor	NN
cord-018387-ci5wx26t	167	48	;	;	:
cord-018387-ci5wx26t	167	49	IGF	IGF	NNP
cord-018387-ci5wx26t	167	50	,	,	,
cord-018387-ci5wx26t	167	51	insulin	insulin	NN
cord-018387-ci5wx26t	167	52	-	-	HYPH
cord-018387-ci5wx26t	167	53	like	like	JJ
cord-018387-ci5wx26t	167	54	growth	growth	NN
cord-018387-ci5wx26t	167	55	factor	factor	NN
cord-018387-ci5wx26t	167	56	.	.	.
cord-018387-ci5wx26t	168	1	(	(	-LRB-
cord-018387-ci5wx26t	168	2	Modified	modify	VBN
cord-018387-ci5wx26t	168	3	from	from	IN
cord-018387-ci5wx26t	168	4	Di	Di	NNP
cord-018387-ci5wx26t	168	5	Benedetto	Benedetto	NNP
cord-018387-ci5wx26t	168	6	et	et	NNP
cord-018387-ci5wx26t	168	7	al	al	NNP
cord-018387-ci5wx26t	168	8	.	.	.
cord-018387-ci5wx26t	169	1	[	[	-LRB-
cord-018387-ci5wx26t	169	2	65	65	CD
cord-018387-ci5wx26t	169	3	]	]	-RRB-
cord-018387-ci5wx26t	169	4	.	.	.
cord-018387-ci5wx26t	170	1	https://	https://	NNP
cord-018387-ci5wx26t	170	2	doi.org/10.1016/j.neubiorev.2017.01.044	doi.org/10.1016/j.neubiorev.2017.01.044	NNP
cord-018387-ci5wx26t	170	3	)	)	-RRB-
cord-018387-ci5wx26t	170	4	play	play	VBP
cord-018387-ci5wx26t	170	5	between	between	IN
cord-018387-ci5wx26t	170	6	secreted	secrete	VBN
cord-018387-ci5wx26t	170	7	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	170	8	modulators	modulator	NNS
cord-018387-ci5wx26t	170	9	and	and	CC
cord-018387-ci5wx26t	170	10	activated	activate	VBN
cord-018387-ci5wx26t	170	11	cell	cell	NN
cord-018387-ci5wx26t	170	12	surface	surface	NN
cord-018387-ci5wx26t	170	13	receptors	receptor	NNS
cord-018387-ci5wx26t	170	14	,	,	,
cord-018387-ci5wx26t	170	15	such	such	JJ
cord-018387-ci5wx26t	170	16	as	as	IN
cord-018387-ci5wx26t	170	17	Tolllike	Tolllike	NNP
cord-018387-ci5wx26t	170	18	receptors	receptor	NNS
cord-018387-ci5wx26t	170	19	(	(	-LRB-
cord-018387-ci5wx26t	170	20	TLRs	TLRs	NNP
cord-018387-ci5wx26t	170	21	)	)	-RRB-
cord-018387-ci5wx26t	170	22	[	[	-LRB-
cord-018387-ci5wx26t	170	23	65	65	CD
cord-018387-ci5wx26t	170	24	]	]	-RRB-
cord-018387-ci5wx26t	170	25	.	.	.
cord-018387-ci5wx26t	171	1	These	these	DT
cord-018387-ci5wx26t	171	2	receptors	receptor	NNS
cord-018387-ci5wx26t	171	3	are	be	VBP
cord-018387-ci5wx26t	171	4	primarily	primarily	RB
cord-018387-ci5wx26t	171	5	expressed	express	VBN
cord-018387-ci5wx26t	171	6	on	on	IN
cord-018387-ci5wx26t	171	7	cells	cell	NNS
cord-018387-ci5wx26t	171	8	that	that	WDT
cord-018387-ci5wx26t	171	9	play	play	VBP
cord-018387-ci5wx26t	171	10	central	central	JJ
cord-018387-ci5wx26t	171	11	roles	role	NNS
cord-018387-ci5wx26t	171	12	in	in	IN
cord-018387-ci5wx26t	171	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	171	14	response	response	NN
cord-018387-ci5wx26t	171	15	,	,	,
cord-018387-ci5wx26t	171	16	including	include	VBG
cord-018387-ci5wx26t	171	17	macrophages	macrophage	NNS
cord-018387-ci5wx26t	171	18	and	and	CC
cord-018387-ci5wx26t	171	19	microglia	microglia	NNS
cord-018387-ci5wx26t	171	20	[	[	-LRB-
cord-018387-ci5wx26t	171	21	80	80	CD
cord-018387-ci5wx26t	171	22	]	]	-RRB-
cord-018387-ci5wx26t	171	23	.	.	.
cord-018387-ci5wx26t	172	1	Activated	activate	VBN
cord-018387-ci5wx26t	172	2	microglia	microglia	NNS
cord-018387-ci5wx26t	172	3	and	and	CC
cord-018387-ci5wx26t	172	4	astrocytes	astrocyte	NNS
cord-018387-ci5wx26t	172	5	change	change	VBP
cord-018387-ci5wx26t	172	6	their	-PRON-	PRP$
cord-018387-ci5wx26t	172	7	morphology	morphology	NN
cord-018387-ci5wx26t	172	8	and	and	CC
cord-018387-ci5wx26t	172	9	function	function	VB
cord-018387-ci5wx26t	172	10	and	and	CC
cord-018387-ci5wx26t	172	11	produce	produce	VB
cord-018387-ci5wx26t	172	12	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	172	13	cytokines	cytokine	NNS
cord-018387-ci5wx26t	172	14	such	such	JJ
cord-018387-ci5wx26t	172	15	as	as	IN
cord-018387-ci5wx26t	172	16	IL-1β	IL-1β	NNP
cord-018387-ci5wx26t	172	17	,	,	,
cord-018387-ci5wx26t	172	18	IL-6	IL-6	NNP
cord-018387-ci5wx26t	172	19	,	,	,
cord-018387-ci5wx26t	172	20	and	and	CC
cord-018387-ci5wx26t	172	21	TNF	TNF	NNP
cord-018387-ci5wx26t	172	22	[	[	-LRB-
cord-018387-ci5wx26t	172	23	65	65	CD
cord-018387-ci5wx26t	172	24	]	]	-RRB-
cord-018387-ci5wx26t	172	25	.	.	.
cord-018387-ci5wx26t	173	1	Recent	recent	JJ
cord-018387-ci5wx26t	173	2	work	work	NN
cord-018387-ci5wx26t	173	3	suggests	suggest	VBZ
cord-018387-ci5wx26t	173	4	that	that	IN
cord-018387-ci5wx26t	173	5	microglia	microglia	NNS
cord-018387-ci5wx26t	173	6	undergo	undergo	VBP
cord-018387-ci5wx26t	173	7	a	a	DT
cord-018387-ci5wx26t	173	8	process	process	NN
cord-018387-ci5wx26t	173	9	of	of	IN
cord-018387-ci5wx26t	173	10	senescence	senescence	NN
cord-018387-ci5wx26t	173	11	,	,	,
cord-018387-ci5wx26t	173	12	similar	similar	JJ
cord-018387-ci5wx26t	173	13	to	to	IN
cord-018387-ci5wx26t	173	14	the	the	DT
cord-018387-ci5wx26t	173	15	one	one	CD
cord-018387-ci5wx26t	173	16	in	in	IN
cord-018387-ci5wx26t	173	17	peripheral	peripheral	JJ
cord-018387-ci5wx26t	173	18	immune	immune	JJ
cord-018387-ci5wx26t	173	19	cells	cell	NNS
cord-018387-ci5wx26t	173	20	.	.	.
cord-018387-ci5wx26t	174	1	Senescent	senescent	JJ
cord-018387-ci5wx26t	174	2	and	and	CC
cord-018387-ci5wx26t	174	3	hyperactive	hyperactive	JJ
cord-018387-ci5wx26t	174	4	microglia	microglia	NNS
cord-018387-ci5wx26t	174	5	have	have	VBP
cord-018387-ci5wx26t	174	6	been	be	VBN
cord-018387-ci5wx26t	174	7	detected	detect	VBN
cord-018387-ci5wx26t	174	8	in	in	IN
cord-018387-ci5wx26t	174	9	the	the	DT
cord-018387-ci5wx26t	174	10	aged	aged	JJ
cord-018387-ci5wx26t	174	11	and	and	CC
cord-018387-ci5wx26t	174	12	diseased	diseased	JJ
cord-018387-ci5wx26t	174	13	brain	brain	NN
cord-018387-ci5wx26t	174	14	[	[	-LRB-
cord-018387-ci5wx26t	174	15	81	81	CD
cord-018387-ci5wx26t	174	16	]	]	-RRB-
cord-018387-ci5wx26t	174	17	.	.	.
cord-018387-ci5wx26t	175	1	The	the	DT
cord-018387-ci5wx26t	175	2	aging	age	VBG
cord-018387-ci5wx26t	175	3	brain	brain	NN
cord-018387-ci5wx26t	175	4	,	,	,
cord-018387-ci5wx26t	175	5	in	in	IN
cord-018387-ci5wx26t	175	6	turn	turn	NN
cord-018387-ci5wx26t	175	7	,	,	,
cord-018387-ci5wx26t	175	8	is	be	VBZ
cord-018387-ci5wx26t	175	9	apparently	apparently	RB
cord-018387-ci5wx26t	175	10	able	able	JJ
cord-018387-ci5wx26t	175	11	to	to	TO
cord-018387-ci5wx26t	175	12	modulate	modulate	VB
cord-018387-ci5wx26t	175	13	the	the	DT
cord-018387-ci5wx26t	175	14	immune	immune	JJ
cord-018387-ci5wx26t	175	15	system	system	NN
cord-018387-ci5wx26t	175	16	and	and	CC
cord-018387-ci5wx26t	175	17	to	to	TO
cord-018387-ci5wx26t	175	18	support	support	VB
cord-018387-ci5wx26t	175	19	the	the	DT
cord-018387-ci5wx26t	175	20	recruitment	recruitment	NN
cord-018387-ci5wx26t	175	21	of	of	IN
cord-018387-ci5wx26t	175	22	immune	immune	JJ
cord-018387-ci5wx26t	175	23	cells	cell	NNS
cord-018387-ci5wx26t	175	24	from	from	IN
cord-018387-ci5wx26t	175	25	the	the	DT
cord-018387-ci5wx26t	175	26	periphery	periphery	NN
cord-018387-ci5wx26t	175	27	,	,	,
cord-018387-ci5wx26t	175	28	thereby	thereby	RB
cord-018387-ci5wx26t	175	29	contributing	contribute	VBG
cord-018387-ci5wx26t	175	30	further	far	RBR
cord-018387-ci5wx26t	175	31	to	to	IN
cord-018387-ci5wx26t	175	32	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	175	33	and	and	CC
cord-018387-ci5wx26t	175	34	neuroinflammation	neuroinflammation	VB
cord-018387-ci5wx26t	175	35	[	[	-LRB-
cord-018387-ci5wx26t	175	36	82	82	CD
cord-018387-ci5wx26t	175	37	]	]	-RRB-
cord-018387-ci5wx26t	175	38	.	.	.
cord-018387-ci5wx26t	176	1	In	in	IN
cord-018387-ci5wx26t	176	2	addition	addition	NN
cord-018387-ci5wx26t	176	3	,	,	,
cord-018387-ci5wx26t	176	4	macrophages	macrophage	NNS
cord-018387-ci5wx26t	176	5	change	change	VBP
cord-018387-ci5wx26t	176	6	their	-PRON-	PRP$
cord-018387-ci5wx26t	176	7	protective	protective	JJ
cord-018387-ci5wx26t	176	8	M2-phenotype	M2-phenotype	NNS
cord-018387-ci5wx26t	176	9	to	to	IN
cord-018387-ci5wx26t	176	10	the	the	DT
cord-018387-ci5wx26t	176	11	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	176	12	M1-phenotype	M1-phenotype	NNS
cord-018387-ci5wx26t	176	13	,	,	,
cord-018387-ci5wx26t	176	14	thus	thus	RB
cord-018387-ci5wx26t	176	15	contributing	contribute	VBG
cord-018387-ci5wx26t	176	16	to	to	IN
cord-018387-ci5wx26t	176	17	further	further	JJ
cord-018387-ci5wx26t	176	18	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	176	19	[	[	-LRB-
cord-018387-ci5wx26t	176	20	65	65	CD
cord-018387-ci5wx26t	176	21	]	]	-RRB-
cord-018387-ci5wx26t	176	22	.	.	.
cord-018387-ci5wx26t	177	1	As	as	IN
cord-018387-ci5wx26t	177	2	the	the	DT
cord-018387-ci5wx26t	177	3	aged	aged	JJ
cord-018387-ci5wx26t	177	4	brain	brain	NN
cord-018387-ci5wx26t	177	5	is	be	VBZ
cord-018387-ci5wx26t	177	6	already	already	RB
cord-018387-ci5wx26t	177	7	"	"	``
cord-018387-ci5wx26t	177	8	primed	prime	VBN
cord-018387-ci5wx26t	177	9	"	"	''
cord-018387-ci5wx26t	177	10	to	to	TO
cord-018387-ci5wx26t	177	11	respond	respond	VB
cord-018387-ci5wx26t	177	12	to	to	IN
cord-018387-ci5wx26t	177	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	177	14	stimuli	stimulus	NNS
cord-018387-ci5wx26t	177	15	,	,	,
cord-018387-ci5wx26t	177	16	additional	additional	JJ
cord-018387-ci5wx26t	177	17	stress	stress	NN
cord-018387-ci5wx26t	177	18	or	or	CC
cord-018387-ci5wx26t	177	19	infection	infection	NN
cord-018387-ci5wx26t	177	20	may	may	MD
cord-018387-ci5wx26t	177	21	induce	induce	VB
cord-018387-ci5wx26t	177	22	more	more	RBR
cord-018387-ci5wx26t	177	23	detrimental	detrimental	JJ
cord-018387-ci5wx26t	177	24	changes	change	NNS
cord-018387-ci5wx26t	177	25	in	in	IN
cord-018387-ci5wx26t	177	26	the	the	DT
cord-018387-ci5wx26t	177	27	cognitive	cognitive	JJ
cord-018387-ci5wx26t	177	28	functioning	functioning	NN
cord-018387-ci5wx26t	177	29	of	of	IN
cord-018387-ci5wx26t	177	30	aged	aged	JJ
cord-018387-ci5wx26t	177	31	individuals	individual	NNS
cord-018387-ci5wx26t	177	32	[	[	-LRB-
cord-018387-ci5wx26t	177	33	78	78	CD
cord-018387-ci5wx26t	177	34	,	,	,
cord-018387-ci5wx26t	177	35	83	83	CD
cord-018387-ci5wx26t	177	36	]	]	-RRB-
cord-018387-ci5wx26t	177	37	.	.	.
cord-018387-ci5wx26t	178	1	Furthermore	furthermore	RB
cord-018387-ci5wx26t	178	2	,	,	,
cord-018387-ci5wx26t	178	3	the	the	DT
cord-018387-ci5wx26t	178	4	age	age	NN
cord-018387-ci5wx26t	178	5	-	-	HYPH
cord-018387-ci5wx26t	178	6	related	relate	VBN
cord-018387-ci5wx26t	178	7	concurrent	concurrent	JJ
cord-018387-ci5wx26t	178	8	reduction	reduction	NN
cord-018387-ci5wx26t	178	9	of	of	IN
cord-018387-ci5wx26t	178	10	anti	anti	JJ
cord-018387-ci5wx26t	178	11	-	-	JJ
cord-018387-ci5wx26t	178	12	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	178	13	molecules	molecule	NNS
cord-018387-ci5wx26t	178	14	also	also	RB
cord-018387-ci5wx26t	178	15	contributes	contribute	VBZ
cord-018387-ci5wx26t	178	16	to	to	IN
cord-018387-ci5wx26t	178	17	a	a	DT
cord-018387-ci5wx26t	178	18	sensitization	sensitization	NN
cord-018387-ci5wx26t	178	19	to	to	IN
cord-018387-ci5wx26t	178	20	extrinsic	extrinsic	JJ
cord-018387-ci5wx26t	178	21	and	and	CC
cord-018387-ci5wx26t	178	22	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	178	23	stressors	stressor	NNS
cord-018387-ci5wx26t	178	24	.	.	.
cord-018387-ci5wx26t	179	1	T	t	NN
cord-018387-ci5wx26t	179	2	cells	cell	NNS
cord-018387-ci5wx26t	179	3	produce	produce	VBP
cord-018387-ci5wx26t	179	4	less	less	JJR
cord-018387-ci5wx26t	179	5	IL-4	IL-4	NNP
cord-018387-ci5wx26t	179	6	and	and	CC
cord-018387-ci5wx26t	179	7	IL-10	IL-10	NNP
cord-018387-ci5wx26t	179	8	and	and	CC
cord-018387-ci5wx26t	179	9	more	more	RBR
cord-018387-ci5wx26t	179	10	interferon	interferon	NN
cord-018387-ci5wx26t	179	11	gamma	gamma	NN
cord-018387-ci5wx26t	179	12	(	(	-LRB-
cord-018387-ci5wx26t	179	13	IFN	IFN	NNP
cord-018387-ci5wx26t	179	14	-	-	HYPH
cord-018387-ci5wx26t	179	15	γ	γ	NNP
cord-018387-ci5wx26t	179	16	)	)	-RRB-
cord-018387-ci5wx26t	179	17	,	,	,
cord-018387-ci5wx26t	179	18	thereby	thereby	RB
cord-018387-ci5wx26t	179	19	promoting	promote	VBG
cord-018387-ci5wx26t	179	20	microglial	microglial	JJ
cord-018387-ci5wx26t	179	21	activation	activation	NN
cord-018387-ci5wx26t	179	22	.	.	.
cord-018387-ci5wx26t	180	1	This	this	DT
cord-018387-ci5wx26t	180	2	has	have	VBZ
cord-018387-ci5wx26t	180	3	detrimental	detrimental	JJ
cord-018387-ci5wx26t	180	4	consequences	consequence	NNS
cord-018387-ci5wx26t	180	5	for	for	IN
cord-018387-ci5wx26t	180	6	neural	neural	JJ
cord-018387-ci5wx26t	180	7	precursor	precursor	NN
cord-018387-ci5wx26t	180	8	cells	cell	NNS
cord-018387-ci5wx26t	180	9	,	,	,
cord-018387-ci5wx26t	180	10	leading	lead	VBG
cord-018387-ci5wx26t	180	11	to	to	IN
cord-018387-ci5wx26t	180	12	a	a	DT
cord-018387-ci5wx26t	180	13	decrease	decrease	NN
cord-018387-ci5wx26t	180	14	of	of	IN
cord-018387-ci5wx26t	180	15	neurogenesis	neurogenesis	NN
cord-018387-ci5wx26t	180	16	(	(	-LRB-
cord-018387-ci5wx26t	180	17	Fig	Fig	NNP
cord-018387-ci5wx26t	180	18	.	.	.
cord-018387-ci5wx26t	180	19	14	14	CD
cord-018387-ci5wx26t	180	20	.	.	.
cord-018387-ci5wx26t	181	1	3	3	LS
cord-018387-ci5wx26t	181	2	)	)	-RRB-
cord-018387-ci5wx26t	181	3	as	as	RB
cord-018387-ci5wx26t	181	4	well	well	RB
cord-018387-ci5wx26t	181	5	as	as	IN
cord-018387-ci5wx26t	181	6	increased	increase	VBN
cord-018387-ci5wx26t	181	7	decrements	decrement	NNS
cord-018387-ci5wx26t	181	8	in	in	IN
cord-018387-ci5wx26t	181	9	learning	learning	NN
cord-018387-ci5wx26t	181	10	and	and	CC
cord-018387-ci5wx26t	181	11	memory	memory	NN
cord-018387-ci5wx26t	181	12	[	[	-LRB-
cord-018387-ci5wx26t	181	13	84	84	CD
cord-018387-ci5wx26t	181	14	,	,	,
cord-018387-ci5wx26t	181	15	85	85	CD
cord-018387-ci5wx26t	181	16	]	]	-RRB-
cord-018387-ci5wx26t	181	17	.	.	.
cord-018387-ci5wx26t	182	1	Taken	take	VBN
cord-018387-ci5wx26t	182	2	together	together	RB
cord-018387-ci5wx26t	182	3	,	,	,
cord-018387-ci5wx26t	182	4	the	the	DT
cord-018387-ci5wx26t	182	5	overproduction	overproduction	NN
cord-018387-ci5wx26t	182	6	of	of	IN
cord-018387-ci5wx26t	182	7	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	182	8	mediators	mediator	NNS
cord-018387-ci5wx26t	182	9	in	in	IN
cord-018387-ci5wx26t	182	10	the	the	DT
cord-018387-ci5wx26t	182	11	periphery	periphery	NN
cord-018387-ci5wx26t	182	12	may	may	MD
cord-018387-ci5wx26t	182	13	induce	induce	VB
cord-018387-ci5wx26t	182	14	a	a	DT
cord-018387-ci5wx26t	182	15	progressive	progressive	JJ
cord-018387-ci5wx26t	182	16	increase	increase	NN
cord-018387-ci5wx26t	182	17	in	in	IN
cord-018387-ci5wx26t	182	18	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	182	19	,	,	,
cord-018387-ci5wx26t	182	20	characterized	characterize	VBN
cord-018387-ci5wx26t	182	21	by	by	IN
cord-018387-ci5wx26t	182	22	increased	increase	VBN
cord-018387-ci5wx26t	182	23	glial	glial	JJ
cord-018387-ci5wx26t	182	24	activation	activation	NN
cord-018387-ci5wx26t	182	25	,	,	,
cord-018387-ci5wx26t	182	26	elevated	elevate	VBD
cord-018387-ci5wx26t	182	27	steady	steady	JJ
cord-018387-ci5wx26t	182	28	-	-	HYPH
cord-018387-ci5wx26t	182	29	state	state	NN
cord-018387-ci5wx26t	182	30	levels	level	NNS
cord-018387-ci5wx26t	182	31	of	of	IN
cord-018387-ci5wx26t	182	32	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	182	33	cytokines	cytokine	NNS
cord-018387-ci5wx26t	182	34	,	,	,
cord-018387-ci5wx26t	182	35	and	and	CC
cord-018387-ci5wx26t	182	36	a	a	DT
cord-018387-ci5wx26t	182	37	decreased	decreased	JJ
cord-018387-ci5wx26t	182	38	production	production	NN
cord-018387-ci5wx26t	182	39	of	of	IN
cord-018387-ci5wx26t	182	40	antiinflammatory	antiinflammatory	JJ
cord-018387-ci5wx26t	182	41	molecules	molecule	NNS
cord-018387-ci5wx26t	182	42	,	,	,
cord-018387-ci5wx26t	182	43	even	even	RB
cord-018387-ci5wx26t	182	44	in	in	IN
cord-018387-ci5wx26t	182	45	neurologically	neurologically	RB
cord-018387-ci5wx26t	182	46	intact	intact	JJ
cord-018387-ci5wx26t	182	47	aged	age	VBN
cord-018387-ci5wx26t	182	48	individuals	individual	NNS
cord-018387-ci5wx26t	182	49	[	[	-LRB-
cord-018387-ci5wx26t	182	50	65	65	CD
cord-018387-ci5wx26t	182	51	]	]	-RRB-
cord-018387-ci5wx26t	182	52	.	.	.
cord-018387-ci5wx26t	183	1	In	in	IN
cord-018387-ci5wx26t	183	2	the	the	DT
cord-018387-ci5wx26t	183	3	next	next	JJ
cord-018387-ci5wx26t	183	4	section	section	NN
cord-018387-ci5wx26t	183	5	,	,	,
cord-018387-ci5wx26t	183	6	we	-PRON-	PRP
cord-018387-ci5wx26t	183	7	consider	consider	VBP
cord-018387-ci5wx26t	183	8	the	the	DT
cord-018387-ci5wx26t	183	9	modulatory	modulatory	JJ
cord-018387-ci5wx26t	183	10	potential	potential	NN
cord-018387-ci5wx26t	183	11	of	of	IN
cord-018387-ci5wx26t	183	12	nutrition	nutrition	NN
cord-018387-ci5wx26t	183	13	in	in	IN
cord-018387-ci5wx26t	183	14	its	-PRON-	PRP$
cord-018387-ci5wx26t	183	15	ability	ability	NN
cord-018387-ci5wx26t	183	16	,	,	,
cord-018387-ci5wx26t	183	17	in	in	IN
cord-018387-ci5wx26t	183	18	combination	combination	NN
cord-018387-ci5wx26t	183	19	with	with	IN
cord-018387-ci5wx26t	183	20	physical	physical	JJ
cord-018387-ci5wx26t	183	21	activity	activity	NN
cord-018387-ci5wx26t	183	22	,	,	,
cord-018387-ci5wx26t	183	23	to	to	TO
cord-018387-ci5wx26t	183	24	mediate	mediate	VB
cord-018387-ci5wx26t	183	25	anti	anti	JJ
cord-018387-ci5wx26t	183	26	-	-	JJ
cord-018387-ci5wx26t	183	27	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	183	28	effects	effect	NNS
cord-018387-ci5wx26t	183	29	and	and	CC
cord-018387-ci5wx26t	183	30	thus	thus	RB
cord-018387-ci5wx26t	183	31	positively	positively	RB
cord-018387-ci5wx26t	183	32	influence	influence	VBP
cord-018387-ci5wx26t	183	33	immunity	immunity	NN
cord-018387-ci5wx26t	183	34	and	and	CC
cord-018387-ci5wx26t	183	35	the	the	DT
cord-018387-ci5wx26t	183	36	aging	age	VBG
cord-018387-ci5wx26t	183	37	brain	brain	NN
cord-018387-ci5wx26t	183	38	.	.	.
cord-018387-ci5wx26t	184	1	Evidence	evidence	NN
cord-018387-ci5wx26t	184	2	that	that	IN
cord-018387-ci5wx26t	184	3	long	long	JJ
cord-018387-ci5wx26t	184	4	-	-	HYPH
cord-018387-ci5wx26t	184	5	term	term	NN
cord-018387-ci5wx26t	184	6	behavioral	behavioral	JJ
cord-018387-ci5wx26t	184	7	changes	change	NNS
cord-018387-ci5wx26t	184	8	,	,	,
cord-018387-ci5wx26t	184	9	including	include	VBG
cord-018387-ci5wx26t	184	10	nutritional	nutritional	JJ
cord-018387-ci5wx26t	184	11	intervention	intervention	NN
cord-018387-ci5wx26t	184	12	and	and	CC
cord-018387-ci5wx26t	184	13	reduced	reduce	VBN
cord-018387-ci5wx26t	184	14	energy	energy	NN
cord-018387-ci5wx26t	184	15	intake	intake	NN
cord-018387-ci5wx26t	184	16	together	together	RB
cord-018387-ci5wx26t	184	17	with	with	IN
cord-018387-ci5wx26t	184	18	physical	physical	JJ
cord-018387-ci5wx26t	184	19	activity	activity	NN
cord-018387-ci5wx26t	184	20	,	,	,
cord-018387-ci5wx26t	184	21	may	may	MD
cord-018387-ci5wx26t	184	22	prevent	prevent	VB
cord-018387-ci5wx26t	184	23	,	,	,
cord-018387-ci5wx26t	184	24	improve	improve	VB
cord-018387-ci5wx26t	184	25	,	,	,
cord-018387-ci5wx26t	184	26	or	or	CC
cord-018387-ci5wx26t	184	27	even	even	RB
cord-018387-ci5wx26t	184	28	reverse	reverse	VB
cord-018387-ci5wx26t	184	29	age	age	NN
cord-018387-ci5wx26t	184	30	-	-	HYPH
cord-018387-ci5wx26t	184	31	related	relate	VBN
cord-018387-ci5wx26t	184	32	impairments	impairment	NNS
cord-018387-ci5wx26t	184	33	in	in	IN
cord-018387-ci5wx26t	184	34	immune	immune	JJ
cord-018387-ci5wx26t	184	35	function	function	NN
cord-018387-ci5wx26t	184	36	continues	continue	VBZ
cord-018387-ci5wx26t	184	37	to	to	TO
cord-018387-ci5wx26t	184	38	accumulate	accumulate	VB
cord-018387-ci5wx26t	184	39	[	[	-LRB-
cord-018387-ci5wx26t	184	40	2	2	CD
cord-018387-ci5wx26t	184	41	]	]	-RRB-
cord-018387-ci5wx26t	184	42	.	.	.
cord-018387-ci5wx26t	185	1	Lifestyle	lifestyle	NN
cord-018387-ci5wx26t	185	2	factors	factor	NNS
cord-018387-ci5wx26t	185	3	,	,	,
cord-018387-ci5wx26t	185	4	such	such	JJ
cord-018387-ci5wx26t	185	5	as	as	IN
cord-018387-ci5wx26t	185	6	diet	diet	NN
cord-018387-ci5wx26t	185	7	and	and	CC
cord-018387-ci5wx26t	185	8	exercise	exercise	NN
cord-018387-ci5wx26t	185	9	,	,	,
cord-018387-ci5wx26t	185	10	have	have	VBP
cord-018387-ci5wx26t	185	11	been	be	VBN
cord-018387-ci5wx26t	185	12	established	establish	VBN
cord-018387-ci5wx26t	185	13	as	as	IN
cord-018387-ci5wx26t	185	14	playing	play	VBG
cord-018387-ci5wx26t	185	15	an	an	DT
cord-018387-ci5wx26t	185	16	important	important	JJ
cord-018387-ci5wx26t	185	17	role	role	NN
cord-018387-ci5wx26t	185	18	in	in	IN
cord-018387-ci5wx26t	185	19	immunosenescence	immunosenescence	NNP
cord-018387-ci5wx26t	185	20	,	,	,
cord-018387-ci5wx26t	185	21	and	and	CC
cord-018387-ci5wx26t	185	22	the	the	DT
cord-018387-ci5wx26t	185	23	practice	practice	NN
cord-018387-ci5wx26t	185	24	of	of	IN
cord-018387-ci5wx26t	185	25	"	"	``
cord-018387-ci5wx26t	185	26	healthy	healthy	JJ
cord-018387-ci5wx26t	185	27	"	"	''
cord-018387-ci5wx26t	185	28	behavior	behavior	NN
cord-018387-ci5wx26t	185	29	may	may	MD
cord-018387-ci5wx26t	185	30	minimize	minimize	VB
cord-018387-ci5wx26t	185	31	the	the	DT
cord-018387-ci5wx26t	185	32	age	age	NN
cord-018387-ci5wx26t	185	33	-	-	HYPH
cord-018387-ci5wx26t	185	34	associated	associate	VBN
cord-018387-ci5wx26t	185	35	decline	decline	NN
cord-018387-ci5wx26t	185	36	of	of	IN
cord-018387-ci5wx26t	185	37	immune	immune	JJ
cord-018387-ci5wx26t	185	38	function	function	NN
cord-018387-ci5wx26t	185	39	(	(	-LRB-
cord-018387-ci5wx26t	185	40	Figs	fig	NNS
cord-018387-ci5wx26t	185	41	.	.	.
cord-018387-ci5wx26t	186	1	14.4	14.4	CD
cord-018387-ci5wx26t	186	2	and	and	CC
cord-018387-ci5wx26t	186	3	14.5	14.5	CD
cord-018387-ci5wx26t	186	4	)	)	-RRB-
cord-018387-ci5wx26t	186	5	.	.	.
cord-018387-ci5wx26t	187	1	Accumulating	accumulate	VBG
cord-018387-ci5wx26t	187	2	data	datum	NNS
cord-018387-ci5wx26t	187	3	strongly	strongly	RB
cord-018387-ci5wx26t	187	4	suggest	suggest	VBP
cord-018387-ci5wx26t	187	5	that	that	IN
cord-018387-ci5wx26t	187	6	inflammation	inflammation	NN
cord-018387-ci5wx26t	187	7	and	and	CC
cord-018387-ci5wx26t	187	8	oxidative	oxidative	JJ
cord-018387-ci5wx26t	187	9	stress	stress	NN
cord-018387-ci5wx26t	187	10	are	be	VBP
cord-018387-ci5wx26t	187	11	the	the	DT
cord-018387-ci5wx26t	187	12	main	main	JJ
cord-018387-ci5wx26t	187	13	inducers	inducer	NNS
cord-018387-ci5wx26t	187	14	of	of	IN
cord-018387-ci5wx26t	187	15	cellular	cellular	JJ
cord-018387-ci5wx26t	187	16	aging	aging	NN
cord-018387-ci5wx26t	187	17	(	(	-LRB-
cord-018387-ci5wx26t	187	18	Fig	Fig	NNP
cord-018387-ci5wx26t	187	19	.	.	.
cord-018387-ci5wx26t	187	20	14.5	14.5	CD
cord-018387-ci5wx26t	187	21	)	)	-RRB-
cord-018387-ci5wx26t	187	22	.	.	.
cord-018387-ci5wx26t	188	1	The	the	DT
cord-018387-ci5wx26t	188	2	cross	cross	NN
cord-018387-ci5wx26t	188	3	talk	talk	NN
cord-018387-ci5wx26t	188	4	between	between	IN
cord-018387-ci5wx26t	188	5	oxidative	oxidative	JJ
cord-018387-ci5wx26t	188	6	stress	stress	NN
cord-018387-ci5wx26t	188	7	and	and	CC
cord-018387-ci5wx26t	188	8	inflammation	inflammation	NN
cord-018387-ci5wx26t	188	9	is	be	VBZ
cord-018387-ci5wx26t	188	10	a	a	DT
cord-018387-ci5wx26t	188	11	complex	complex	JJ
cord-018387-ci5wx26t	188	12	process	process	NN
cord-018387-ci5wx26t	188	13	,	,	,
cord-018387-ci5wx26t	188	14	and	and	CC
cord-018387-ci5wx26t	188	15	there	there	EX
cord-018387-ci5wx26t	188	16	are	be	VBP
cord-018387-ci5wx26t	188	17	studies	study	NNS
cord-018387-ci5wx26t	188	18	reporting	report	VBG
cord-018387-ci5wx26t	188	19	that	that	IN
cord-018387-ci5wx26t	188	20	ROS	ROS	NNP
cord-018387-ci5wx26t	188	21	can	can	MD
cord-018387-ci5wx26t	188	22	stimulate	stimulate	VB
cord-018387-ci5wx26t	188	23	inflammation	inflammation	NN
cord-018387-ci5wx26t	188	24	via	via	IN
cord-018387-ci5wx26t	188	25	the	the	DT
cord-018387-ci5wx26t	188	26	activation	activation	NN
cord-018387-ci5wx26t	188	27	of	of	IN
cord-018387-ci5wx26t	188	28	inflammasomes	inflammasome	NNS
cord-018387-ci5wx26t	188	29	and	and	CC
cord-018387-ci5wx26t	188	30	the	the	DT
cord-018387-ci5wx26t	188	31	production	production	NN
cord-018387-ci5wx26t	188	32	of	of	IN
cord-018387-ci5wx26t	188	33	cytokines	cytokine	NNS
cord-018387-ci5wx26t	188	34	such	such	JJ
cord-018387-ci5wx26t	188	35	as	as	IN
cord-018387-ci5wx26t	188	36	IL-1β	IL-1β	NNP
cord-018387-ci5wx26t	188	37	and	and	CC
cord-018387-ci5wx26t	188	38	IL-18	IL-18	NNP
cord-018387-ci5wx26t	188	39	,	,	,
cord-018387-ci5wx26t	188	40	which	which	WDT
cord-018387-ci5wx26t	188	41	subsequently	subsequently	RB
cord-018387-ci5wx26t	188	42	trigger	trigger	VBP
cord-018387-ci5wx26t	188	43	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	188	44	responses	response	NNS
cord-018387-ci5wx26t	188	45	[	[	-LRB-
cord-018387-ci5wx26t	188	46	86	86	CD
cord-018387-ci5wx26t	188	47	]	]	-RRB-
cord-018387-ci5wx26t	188	48	.	.	.
cord-018387-ci5wx26t	189	1	At	at	IN
cord-018387-ci5wx26t	189	2	least	least	JJS
cord-018387-ci5wx26t	189	3	in	in	IN
cord-018387-ci5wx26t	189	4	the	the	DT
cord-018387-ci5wx26t	189	5	context	context	NN
cord-018387-ci5wx26t	189	6	of	of	IN
cord-018387-ci5wx26t	189	7	adiposity	adiposity	NN
cord-018387-ci5wx26t	189	8	and	and	CC
cord-018387-ci5wx26t	189	9	inflammation	inflammation	NN
cord-018387-ci5wx26t	189	10	mentioned	mention	VBN
cord-018387-ci5wx26t	189	11	above	above	RB
cord-018387-ci5wx26t	189	12	,	,	,
cord-018387-ci5wx26t	189	13	as	as	RB
cord-018387-ci5wx26t	189	14	well	well	RB
cord-018387-ci5wx26t	189	15	as	as	IN
cord-018387-ci5wx26t	189	16	via	via	IN
cord-018387-ci5wx26t	189	17	multiple	multiple	JJ
cord-018387-ci5wx26t	189	18	other	other	JJ
cord-018387-ci5wx26t	189	19	postulated	postulate	VBN
cord-018387-ci5wx26t	189	20	physiological	physiological	JJ
cord-018387-ci5wx26t	189	21	effects	effect	NNS
cord-018387-ci5wx26t	189	22	,	,	,
cord-018387-ci5wx26t	189	23	caloric	caloric	JJ
cord-018387-ci5wx26t	189	24	restriction	restriction	NN
cord-018387-ci5wx26t	189	25	(	(	-LRB-
cord-018387-ci5wx26t	189	26	CR	CR	NNP
cord-018387-ci5wx26t	189	27	)	)	-RRB-
cord-018387-ci5wx26t	189	28	in	in	IN
cord-018387-ci5wx26t	189	29	humans	human	NNS
cord-018387-ci5wx26t	189	30	might	may	MD
cord-018387-ci5wx26t	189	31	have	have	VB
cord-018387-ci5wx26t	189	32	beneficial	beneficial	JJ
cord-018387-ci5wx26t	189	33	effects	effect	NNS
cord-018387-ci5wx26t	189	34	in	in	IN
cord-018387-ci5wx26t	189	35	terms	term	NNS
cord-018387-ci5wx26t	189	36	of	of	IN
cord-018387-ci5wx26t	189	37	lowering	lower	VBG
cord-018387-ci5wx26t	189	38	metabolism	metabolism	NN
cord-018387-ci5wx26t	189	39	,	,	,
cord-018387-ci5wx26t	189	40	a	a	DT
cord-018387-ci5wx26t	189	41	reduction	reduction	NN
cord-018387-ci5wx26t	189	42	of	of	IN
cord-018387-ci5wx26t	189	43	visceral	visceral	JJ
cord-018387-ci5wx26t	189	44	fat	fat	NN
cord-018387-ci5wx26t	189	45	,	,	,
cord-018387-ci5wx26t	189	46	and	and	CC
cord-018387-ci5wx26t	189	47	weight	weight	NN
cord-018387-ci5wx26t	189	48	loss	loss	NN
cord-018387-ci5wx26t	189	49	[	[	-LRB-
cord-018387-ci5wx26t	189	50	2	2	CD
cord-018387-ci5wx26t	189	51	]	]	-RRB-
cord-018387-ci5wx26t	189	52	.	.	.
cord-018387-ci5wx26t	190	1	CR	CR	NNP
cord-018387-ci5wx26t	190	2	has	have	VBZ
cord-018387-ci5wx26t	190	3	been	be	VBN
cord-018387-ci5wx26t	190	4	shown	show	VBN
cord-018387-ci5wx26t	190	5	to	to	TO
cord-018387-ci5wx26t	190	6	delay	delay	VB
cord-018387-ci5wx26t	190	7	signs	sign	NNS
cord-018387-ci5wx26t	190	8	of	of	IN
cord-018387-ci5wx26t	190	9	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	190	10	in	in	IN
cord-018387-ci5wx26t	190	11	animals	animal	NNS
cord-018387-ci5wx26t	190	12	and	and	CC
cord-018387-ci5wx26t	190	13	is	be	VBZ
cord-018387-ci5wx26t	190	14	considered	consider	VBN
cord-018387-ci5wx26t	190	15	today	today	NN
cord-018387-ci5wx26t	190	16	as	as	IN
cord-018387-ci5wx26t	190	17	the	the	DT
cord-018387-ci5wx26t	190	18	only	only	RB
cord-018387-ci5wx26t	190	19	known	know	VBN
cord-018387-ci5wx26t	190	20	method	method	NN
cord-018387-ci5wx26t	190	21	to	to	TO
cord-018387-ci5wx26t	190	22	prolong	prolong	VB
cord-018387-ci5wx26t	190	23	median	median	NN
cord-018387-ci5wx26t	190	24	as	as	RB
cord-018387-ci5wx26t	190	25	well	well	RB
cord-018387-ci5wx26t	190	26	as	as	IN
cord-018387-ci5wx26t	190	27	maximal	maximal	JJ
cord-018387-ci5wx26t	190	28	lifespan	lifespan	NN
cord-018387-ci5wx26t	190	29	in	in	IN
cord-018387-ci5wx26t	190	30	several	several	JJ
cord-018387-ci5wx26t	190	31	tested	test	VBN
cord-018387-ci5wx26t	190	32	species	specie	NNS
cord-018387-ci5wx26t	190	33	,	,	,
cord-018387-ci5wx26t	190	34	from	from	IN
cord-018387-ci5wx26t	190	35	invertebrates	invertebrate	NNS
cord-018387-ci5wx26t	190	36	to	to	IN
cord-018387-ci5wx26t	190	37	rodents	rodent	NNS
cord-018387-ci5wx26t	190	38	and	and	CC
cord-018387-ci5wx26t	190	39	even	even	RB
cord-018387-ci5wx26t	190	40	including	include	VBG
cord-018387-ci5wx26t	190	41	nonhuman	nonhuman	NN
cord-018387-ci5wx26t	190	42	primates	primate	NNS
cord-018387-ci5wx26t	190	43	[	[	-LRB-
cord-018387-ci5wx26t	190	44	32	32	CD
cord-018387-ci5wx26t	190	45	,	,	,
cord-018387-ci5wx26t	190	46	87	87	CD
cord-018387-ci5wx26t	190	47	]	]	-RRB-
cord-018387-ci5wx26t	190	48	.	.	.
cord-018387-ci5wx26t	191	1	Thus	thus	RB
cord-018387-ci5wx26t	191	2	,	,	,
cord-018387-ci5wx26t	191	3	in	in	IN
cord-018387-ci5wx26t	191	4	rodents	rodent	NNS
cord-018387-ci5wx26t	191	5	and	and	CC
cord-018387-ci5wx26t	191	6	nonhuman	nonhuman	NN
cord-018387-ci5wx26t	191	7	primates	primate	NNS
cord-018387-ci5wx26t	191	8	,	,	,
cord-018387-ci5wx26t	191	9	CR	CR	NNP
cord-018387-ci5wx26t	191	10	leads	lead	VBZ
cord-018387-ci5wx26t	191	11	to	to	IN
cord-018387-ci5wx26t	191	12	an	an	DT
cord-018387-ci5wx26t	191	13	attenuation	attenuation	NN
cord-018387-ci5wx26t	191	14	of	of	IN
cord-018387-ci5wx26t	191	15	the	the	DT
cord-018387-ci5wx26t	191	16	age	age	NN
cord-018387-ci5wx26t	191	17	-	-	HYPH
cord-018387-ci5wx26t	191	18	related	relate	VBN
cord-018387-ci5wx26t	191	19	shift	shift	NN
cord-018387-ci5wx26t	191	20	from	from	IN
cord-018387-ci5wx26t	191	21	naïve	naïve	JJ
cord-018387-ci5wx26t	191	22	to	to	TO
cord-018387-ci5wx26t	191	23	memoryphenotype	memoryphenotype	NNP
cord-018387-ci5wx26t	191	24	T	t	NN
cord-018387-ci5wx26t	191	25	cells	cell	NNS
cord-018387-ci5wx26t	191	26	and	and	CC
cord-018387-ci5wx26t	191	27	maintains	maintain	VBZ
cord-018387-ci5wx26t	191	28	a	a	DT
cord-018387-ci5wx26t	191	29	higher	high	JJR
cord-018387-ci5wx26t	191	30	number	number	NN
cord-018387-ci5wx26t	191	31	of	of	IN
cord-018387-ci5wx26t	191	32	naïve	naïve	JJ
cord-018387-ci5wx26t	191	33	T	t	NN
cord-018387-ci5wx26t	191	34	cells	cell	NNS
cord-018387-ci5wx26t	191	35	in	in	IN
cord-018387-ci5wx26t	191	36	aged	aged	JJ
cord-018387-ci5wx26t	191	37	animals	animal	NNS
cord-018387-ci5wx26t	191	38	[	[	-LRB-
cord-018387-ci5wx26t	191	39	88	88	CD
cord-018387-ci5wx26t	191	40	]	]	-RRB-
cord-018387-ci5wx26t	191	41	.	.	.
cord-018387-ci5wx26t	192	1	Furthermore	furthermore	RB
cord-018387-ci5wx26t	192	2	,	,	,
cord-018387-ci5wx26t	192	3	the	the	DT
cord-018387-ci5wx26t	192	4	age	age	NN
cord-018387-ci5wx26t	192	5	-	-	HYPH
cord-018387-ci5wx26t	192	6	associated	associate	VBN
cord-018387-ci5wx26t	192	7	rise	rise	NN
cord-018387-ci5wx26t	192	8	of	of	IN
cord-018387-ci5wx26t	192	9	pro	pro	JJ
cord-018387-ci5wx26t	192	10	-	-	JJ
cord-018387-ci5wx26t	192	11	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	192	12	cytokines	cytokine	NNS
cord-018387-ci5wx26t	192	13	,	,	,
cord-018387-ci5wx26t	192	14	such	such	JJ
cord-018387-ci5wx26t	192	15	as	as	IN
cord-018387-ci5wx26t	192	16	IL-6	IL-6	NNP
cord-018387-ci5wx26t	192	17	,	,	,
cord-018387-ci5wx26t	192	18	IFN	IFN	NNP
cord-018387-ci5wx26t	192	19	-	-	HYPH
cord-018387-ci5wx26t	192	20	γ	γ	NNP
cord-018387-ci5wx26t	192	21	,	,	,
cord-018387-ci5wx26t	192	22	and	and	CC
cord-018387-ci5wx26t	192	23	TNF	TNF	NNP
cord-018387-ci5wx26t	192	24	,	,	,
cord-018387-ci5wx26t	192	25	and	and	CC
cord-018387-ci5wx26t	192	26	the	the	DT
cord-018387-ci5wx26t	192	27	resulting	result	VBG
cord-018387-ci5wx26t	192	28	pro	pro	JJ
cord-018387-ci5wx26t	192	29	-	-	JJ
cord-018387-ci5wx26t	192	30	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	192	31	state	state	NN
cord-018387-ci5wx26t	192	32	of	of	IN
cord-018387-ci5wx26t	192	33	an	an	DT
cord-018387-ci5wx26t	192	34	aged	aged	JJ
cord-018387-ci5wx26t	192	35	immune	immune	JJ
cord-018387-ci5wx26t	192	36	system	system	NN
cord-018387-ci5wx26t	192	37	can	can	MD
cord-018387-ci5wx26t	192	38	be	be	VB
cord-018387-ci5wx26t	192	39	reversed	reverse	VBN
cord-018387-ci5wx26t	192	40	by	by	IN
cord-018387-ci5wx26t	192	41	CR	CR	NNP
cord-018387-ci5wx26t	192	42	.	.	.
cord-018387-ci5wx26t	193	1	It	-PRON-	PRP
cord-018387-ci5wx26t	193	2	has	have	VBZ
cord-018387-ci5wx26t	193	3	been	be	VBN
cord-018387-ci5wx26t	193	4	reported	report	VBN
cord-018387-ci5wx26t	193	5	that	that	IN
cord-018387-ci5wx26t	193	6	the	the	DT
cord-018387-ci5wx26t	193	7	age	age	NN
cord-018387-ci5wx26t	193	8	-	-	HYPH
cord-018387-ci5wx26t	193	9	related	relate	VBN
cord-018387-ci5wx26t	193	10	decrease	decrease	NN
cord-018387-ci5wx26t	193	11	in	in	IN
cord-018387-ci5wx26t	193	12	the	the	DT
cord-018387-ci5wx26t	193	13	proliferative	proliferative	JJ
cord-018387-ci5wx26t	193	14	capacity	capacity	NN
cord-018387-ci5wx26t	193	15	of	of	IN
cord-018387-ci5wx26t	193	16	T	t	NN
cord-018387-ci5wx26t	193	17	cells	cell	NNS
cord-018387-ci5wx26t	193	18	(	(	-LRB-
cord-018387-ci5wx26t	193	19	due	due	IN
cord-018387-ci5wx26t	193	20	to	to	IN
cord-018387-ci5wx26t	193	21	the	the	DT
cord-018387-ci5wx26t	193	22	shift	shift	NN
cord-018387-ci5wx26t	193	23	from	from	IN
cord-018387-ci5wx26t	193	24	naïve	naïve	JJ
cord-018387-ci5wx26t	193	25	to	to	IN
cord-018387-ci5wx26t	193	26	memory	memory	NN
cord-018387-ci5wx26t	193	27	-	-	HYPH
cord-018387-ci5wx26t	193	28	phenotype	phenotype	NN
cord-018387-ci5wx26t	193	29	T	t	NN
cord-018387-ci5wx26t	193	30	cells	cell	NNS
cord-018387-ci5wx26t	193	31	)	)	-RRB-
cord-018387-ci5wx26t	193	32	can	can	MD
cord-018387-ci5wx26t	193	33	be	be	VB
cord-018387-ci5wx26t	193	34	reversed	reverse	VBN
cord-018387-ci5wx26t	193	35	by	by	IN
cord-018387-ci5wx26t	193	36	CR	CR	NNP
cord-018387-ci5wx26t	193	37	[	[	-LRB-
cord-018387-ci5wx26t	193	38	2	2	CD
cord-018387-ci5wx26t	193	39	,	,	,
cord-018387-ci5wx26t	193	40	32	32	CD
cord-018387-ci5wx26t	193	41	]	]	-RRB-
cord-018387-ci5wx26t	193	42	.	.	.
cord-018387-ci5wx26t	194	1	Nevertheless	nevertheless	RB
cord-018387-ci5wx26t	194	2	,	,	,
cord-018387-ci5wx26t	194	3	there	there	EX
cord-018387-ci5wx26t	194	4	are	be	VBP
cord-018387-ci5wx26t	194	5	still	still	RB
cord-018387-ci5wx26t	194	6	many	many	JJ
cord-018387-ci5wx26t	194	7	open	open	JJ
cord-018387-ci5wx26t	194	8	questions	question	NNS
cord-018387-ci5wx26t	194	9	concerning	concern	VBG
cord-018387-ci5wx26t	194	10	CR	cr	NN
cord-018387-ci5wx26t	194	11	,	,	,
cord-018387-ci5wx26t	194	12	which	which	WDT
cord-018387-ci5wx26t	194	13	has	have	VBZ
cord-018387-ci5wx26t	194	14	been	be	VBN
cord-018387-ci5wx26t	194	15	shown	show	VBN
cord-018387-ci5wx26t	194	16	to	to	TO
cord-018387-ci5wx26t	194	17	be	be	VB
cord-018387-ci5wx26t	194	18	effective	effective	JJ
cord-018387-ci5wx26t	194	19	in	in	IN
cord-018387-ci5wx26t	194	20	improving	improve	VBG
cord-018387-ci5wx26t	194	21	the	the	DT
cord-018387-ci5wx26t	194	22	immune	immune	JJ
cord-018387-ci5wx26t	194	23	response	response	NN
cord-018387-ci5wx26t	194	24	in	in	IN
cord-018387-ci5wx26t	194	25	unchallenged	unchallenged	JJ
cord-018387-ci5wx26t	194	26	animals	animal	NNS
cord-018387-ci5wx26t	194	27	,	,	,
cord-018387-ci5wx26t	194	28	although	although	IN
cord-018387-ci5wx26t	194	29	it	-PRON-	PRP
cord-018387-ci5wx26t	194	30	might	may	MD
cord-018387-ci5wx26t	194	31	compromise	compromise	VB
cord-018387-ci5wx26t	194	32	the	the	DT
cord-018387-ci5wx26t	194	33	host	host	NN
cord-018387-ci5wx26t	194	34	's	's	POS
cord-018387-ci5wx26t	194	35	defense	defense	NN
cord-018387-ci5wx26t	194	36	against	against	IN
cord-018387-ci5wx26t	194	37	pathogenic	pathogenic	JJ
cord-018387-ci5wx26t	194	38	infection	infection	NN
cord-018387-ci5wx26t	194	39	and	and	CC
cord-018387-ci5wx26t	194	40	result	result	VB
cord-018387-ci5wx26t	194	41	in	in	IN
cord-018387-ci5wx26t	194	42	higher	high	JJR
cord-018387-ci5wx26t	194	43	morbidity	morbidity	NN
cord-018387-ci5wx26t	194	44	and	and	CC
cord-018387-ci5wx26t	194	45	mortality	mortality	NN
cord-018387-ci5wx26t	194	46	outside	outside	IN
cord-018387-ci5wx26t	194	47	the	the	DT
cord-018387-ci5wx26t	194	48	laboratory	laboratory	NN
cord-018387-ci5wx26t	194	49	.	.	.
cord-018387-ci5wx26t	195	1	Moreover	moreover	RB
cord-018387-ci5wx26t	195	2	,	,	,
cord-018387-ci5wx26t	195	3	CR	CR	NNP
cord-018387-ci5wx26t	195	4	has	have	VBZ
cord-018387-ci5wx26t	195	5	been	be	VBN
cord-018387-ci5wx26t	195	6	shown	show	VBN
cord-018387-ci5wx26t	195	7	to	to	TO
cord-018387-ci5wx26t	195	8	delay	delay	VB
cord-018387-ci5wx26t	195	9	immunosenescence	immunosenescence	RB
cord-018387-ci5wx26t	195	10	in	in	IN
cord-018387-ci5wx26t	195	11	animals	animal	NNS
cord-018387-ci5wx26t	195	12	,	,	,
cord-018387-ci5wx26t	195	13	but	but	CC
cord-018387-ci5wx26t	195	14	this	this	DT
cord-018387-ci5wx26t	195	15	effect	effect	NN
cord-018387-ci5wx26t	195	16	needs	need	VBZ
cord-018387-ci5wx26t	195	17	to	to	TO
cord-018387-ci5wx26t	195	18	be	be	VB
cord-018387-ci5wx26t	195	19	verified	verify	VBN
cord-018387-ci5wx26t	195	20	in	in	IN
cord-018387-ci5wx26t	195	21	humans	human	NNS
cord-018387-ci5wx26t	195	22	.	.	.
cord-018387-ci5wx26t	196	1	Furthermore	furthermore	RB
cord-018387-ci5wx26t	196	2	,	,	,
cord-018387-ci5wx26t	196	3	short	short	JJ
cord-018387-ci5wx26t	196	4	-	-	HYPH
cord-018387-ci5wx26t	196	5	term	term	NN
cord-018387-ci5wx26t	196	6	CR	CR	NNP
cord-018387-ci5wx26t	196	7	may	may	MD
cord-018387-ci5wx26t	196	8	well	well	RB
cord-018387-ci5wx26t	196	9	be	be	VB
cord-018387-ci5wx26t	196	10	feasible	feasible	JJ
cord-018387-ci5wx26t	196	11	,	,	,
cord-018387-ci5wx26t	196	12	whereas	whereas	IN
cord-018387-ci5wx26t	196	13	long	long	JJ
cord-018387-ci5wx26t	196	14	-	-	HYPH
cord-018387-ci5wx26t	196	15	term	term	NN
cord-018387-ci5wx26t	196	16	dietary	dietary	JJ
cord-018387-ci5wx26t	196	17	restriction	restriction	NN
cord-018387-ci5wx26t	196	18	might	may	MD
cord-018387-ci5wx26t	196	19	have	have	VB
cord-018387-ci5wx26t	196	20	detrimental	detrimental	JJ
cord-018387-ci5wx26t	196	21	psychological	psychological	JJ
cord-018387-ci5wx26t	196	22	and	and	CC
cord-018387-ci5wx26t	196	23	other	other	JJ
cord-018387-ci5wx26t	196	24	effects	effect	NNS
cord-018387-ci5wx26t	196	25	in	in	IN
cord-018387-ci5wx26t	196	26	humans	human	NNS
cord-018387-ci5wx26t	196	27	,	,	,
cord-018387-ci5wx26t	196	28	especially	especially	RB
cord-018387-ci5wx26t	196	29	in	in	IN
cord-018387-ci5wx26t	196	30	the	the	DT
cord-018387-ci5wx26t	196	31	older	old	JJR
cord-018387-ci5wx26t	196	32	population	population	NN
cord-018387-ci5wx26t	196	33	,	,	,
cord-018387-ci5wx26t	196	34	making	make	VBG
cord-018387-ci5wx26t	196	35	its	-PRON-	PRP$
cord-018387-ci5wx26t	196	36	practicality	practicality	NN
cord-018387-ci5wx26t	196	37	questionable	questionable	JJ
cord-018387-ci5wx26t	196	38	[	[	-LRB-
cord-018387-ci5wx26t	196	39	2	2	CD
cord-018387-ci5wx26t	196	40	,	,	,
cord-018387-ci5wx26t	196	41	89	89	CD
cord-018387-ci5wx26t	196	42	,	,	,
cord-018387-ci5wx26t	196	43	90	90	CD
cord-018387-ci5wx26t	196	44	]	]	-RRB-
cord-018387-ci5wx26t	196	45	.	.	.
cord-018387-ci5wx26t	197	1	Nevertheless	nevertheless	RB
cord-018387-ci5wx26t	197	2	,	,	,
cord-018387-ci5wx26t	197	3	the	the	DT
cord-018387-ci5wx26t	197	4	recent	recent	JJ
cord-018387-ci5wx26t	197	5	results	result	NNS
cord-018387-ci5wx26t	197	6	from	from	IN
cord-018387-ci5wx26t	197	7	a	a	DT
cord-018387-ci5wx26t	197	8	multicentered	multicentered	JJ
cord-018387-ci5wx26t	197	9	,	,	,
cord-018387-ci5wx26t	197	10	randomized	randomized	JJ
cord-018387-ci5wx26t	197	11	clinical	clinical	JJ
cord-018387-ci5wx26t	197	12	trial	trial	NN
cord-018387-ci5wx26t	197	13	have	have	VBP
cord-018387-ci5wx26t	197	14	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	197	15	that	that	IN
cord-018387-ci5wx26t	197	16	long	long	JJ
cord-018387-ci5wx26t	197	17	-	-	HYPH
cord-018387-ci5wx26t	197	18	term	term	NN
cord-018387-ci5wx26t	197	19	moderate	moderate	JJ
cord-018387-ci5wx26t	197	20	CR	cr	NN
cord-018387-ci5wx26t	197	21	without	without	IN
cord-018387-ci5wx26t	197	22	malnutrition	malnutrition	NN
cord-018387-ci5wx26t	197	23	induces	induce	VBZ
cord-018387-ci5wx26t	197	24	a	a	DT
cord-018387-ci5wx26t	197	25	significant	significant	JJ
cord-018387-ci5wx26t	197	26	and	and	CC
cord-018387-ci5wx26t	197	27	persistent	persistent	JJ
cord-018387-ci5wx26t	197	28	inhibition	inhibition	NN
cord-018387-ci5wx26t	197	29	of	of	IN
cord-018387-ci5wx26t	197	30	inflammation	inflammation	NN
cord-018387-ci5wx26t	197	31	in	in	IN
cord-018387-ci5wx26t	197	32	young	young	JJ
cord-018387-ci5wx26t	197	33	and	and	CC
cord-018387-ci5wx26t	197	34	middle	middle	JJ
cord-018387-ci5wx26t	197	35	-	-	HYPH
cord-018387-ci5wx26t	197	36	aged	aged	JJ
cord-018387-ci5wx26t	197	37	healthy	healthy	JJ
cord-018387-ci5wx26t	197	38	nonobese	nonobese	JJ
cord-018387-ci5wx26t	197	39	adults	adult	NNS
cord-018387-ci5wx26t	197	40	without	without	IN
cord-018387-ci5wx26t	197	41	impairing	impair	VBG
cord-018387-ci5wx26t	197	42	the	the	DT
cord-018387-ci5wx26t	197	43	cell	cell	NN
cord-018387-ci5wx26t	197	44	-	-	HYPH
cord-018387-ci5wx26t	197	45	mediated	mediate	VBN
cord-018387-ci5wx26t	197	46	immunity	immunity	NN
cord-018387-ci5wx26t	197	47	[	[	-LRB-
cord-018387-ci5wx26t	197	48	91	91	CD
cord-018387-ci5wx26t	197	49	]	]	-RRB-
cord-018387-ci5wx26t	197	50	.	.	.
cord-018387-ci5wx26t	198	1	The	the	DT
cord-018387-ci5wx26t	198	2	optimization	optimization	NN
cord-018387-ci5wx26t	198	3	of	of	IN
cord-018387-ci5wx26t	198	4	nutrition	nutrition	NN
cord-018387-ci5wx26t	198	5	may	may	MD
cord-018387-ci5wx26t	198	6	represent	represent	VB
cord-018387-ci5wx26t	198	7	one	one	CD
cord-018387-ci5wx26t	198	8	of	of	IN
cord-018387-ci5wx26t	198	9	the	the	DT
cord-018387-ci5wx26t	198	10	first	first	JJ
cord-018387-ci5wx26t	198	11	and	and	CC
cord-018387-ci5wx26t	198	12	theoretically	theoretically	RB
cord-018387-ci5wx26t	198	13	easiest	easy	JJS
cord-018387-ci5wx26t	198	14	and	and	CC
cord-018387-ci5wx26t	198	15	cheapest	cheap	JJS
cord-018387-ci5wx26t	198	16	strategies	strategy	NNS
cord-018387-ci5wx26t	198	17	that	that	WDT
cord-018387-ci5wx26t	198	18	can	can	MD
cord-018387-ci5wx26t	198	19	be	be	VB
cord-018387-ci5wx26t	198	20	employed	employ	VBN
cord-018387-ci5wx26t	198	21	to	to	TO
cord-018387-ci5wx26t	198	22	preserve	preserve	VB
cord-018387-ci5wx26t	198	23	health	health	NN
cord-018387-ci5wx26t	198	24	during	during	IN
cord-018387-ci5wx26t	198	25	aging	age	VBG
cord-018387-ci5wx26t	198	26	[	[	-LRB-
cord-018387-ci5wx26t	198	27	2	2	CD
cord-018387-ci5wx26t	198	28	]	]	-RRB-
cord-018387-ci5wx26t	198	29	.	.	.
cord-018387-ci5wx26t	199	1	The	the	DT
cord-018387-ci5wx26t	199	2	development	development	NN
cord-018387-ci5wx26t	199	3	of	of	IN
cord-018387-ci5wx26t	199	4	"	"	``
cord-018387-ci5wx26t	199	5	elderly	elderly	JJ
cord-018387-ci5wx26t	199	6	specific	specific	JJ
cord-018387-ci5wx26t	199	7	,	,	,
cord-018387-ci5wx26t	199	8	"	"	``
cord-018387-ci5wx26t	199	9	functional	functional	JJ
cord-018387-ci5wx26t	199	10	foods	food	NNS
cord-018387-ci5wx26t	199	11	,	,	,
cord-018387-ci5wx26t	199	12	containing	contain	VBG
cord-018387-ci5wx26t	199	13	probiotics	probiotic	NNS
cord-018387-ci5wx26t	199	14	and/or	and/or	CC
cord-018387-ci5wx26t	199	15	prebiotics	prebiotic	NNS
cord-018387-ci5wx26t	199	16	,	,	,
cord-018387-ci5wx26t	199	17	may	may	MD
cord-018387-ci5wx26t	199	18	help	help	VB
cord-018387-ci5wx26t	199	19	in	in	IN
cord-018387-ci5wx26t	199	20	preventing	prevent	VBG
cord-018387-ci5wx26t	199	21	the	the	DT
cord-018387-ci5wx26t	199	22	age	age	NN
cord-018387-ci5wx26t	199	23	-	-	HYPH
cord-018387-ci5wx26t	199	24	related	relate	VBN
cord-018387-ci5wx26t	199	25	disruption	disruption	NN
cord-018387-ci5wx26t	199	26	of	of	IN
cord-018387-ci5wx26t	199	27	the	the	DT
cord-018387-ci5wx26t	199	28	gut	gut	NN
cord-018387-ci5wx26t	199	29	environment	environment	NN
cord-018387-ci5wx26t	199	30	[	[	-LRB-
cord-018387-ci5wx26t	199	31	92	92	CD
cord-018387-ci5wx26t	199	32	]	]	-RRB-
cord-018387-ci5wx26t	199	33	.	.	.
cord-018387-ci5wx26t	200	1	In	in	IN
cord-018387-ci5wx26t	200	2	fact	fact	NN
cord-018387-ci5wx26t	200	3	,	,	,
cord-018387-ci5wx26t	200	4	it	-PRON-	PRP
cord-018387-ci5wx26t	200	5	has	have	VBZ
cord-018387-ci5wx26t	200	6	been	be	VBN
cord-018387-ci5wx26t	200	7	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	200	8	that	that	IN
cord-018387-ci5wx26t	200	9	the	the	DT
cord-018387-ci5wx26t	200	10	maintenance	maintenance	NN
cord-018387-ci5wx26t	200	11	of	of	IN
cord-018387-ci5wx26t	200	12	a	a	DT
cord-018387-ci5wx26t	200	13	"	"	``
cord-018387-ci5wx26t	200	14	healthy	healthy	JJ
cord-018387-ci5wx26t	200	15	"	"	''
cord-018387-ci5wx26t	200	16	gut	gut	NN
cord-018387-ci5wx26t	200	17	microbiota	microbiota	NN
cord-018387-ci5wx26t	200	18	during	during	IN
cord-018387-ci5wx26t	200	19	aging	age	VBG
cord-018387-ci5wx26t	200	20	could	could	MD
cord-018387-ci5wx26t	200	21	help	help	VB
cord-018387-ci5wx26t	200	22	to	to	TO
cord-018387-ci5wx26t	200	23	delay	delay	VB
cord-018387-ci5wx26t	200	24	or	or	CC
cord-018387-ci5wx26t	200	25	prevent	prevent	VB
cord-018387-ci5wx26t	200	26	the	the	DT
cord-018387-ci5wx26t	200	27	inflammaging	inflammaging	NN
cord-018387-ci5wx26t	200	28	process	process	NN
cord-018387-ci5wx26t	200	29	[	[	-LRB-
cord-018387-ci5wx26t	200	30	93	93	CD
cord-018387-ci5wx26t	200	31	]	]	-RRB-
cord-018387-ci5wx26t	200	32	.	.	.
cord-018387-ci5wx26t	201	1	Immunostimulatory	Immunostimulatory	NNP
cord-018387-ci5wx26t	201	2	properties	property	NNS
cord-018387-ci5wx26t	201	3	,	,	,
cord-018387-ci5wx26t	201	4	such	such	JJ
cord-018387-ci5wx26t	201	5	as	as	IN
cord-018387-ci5wx26t	201	6	the	the	DT
cord-018387-ci5wx26t	201	7	modulation	modulation	NN
cord-018387-ci5wx26t	201	8	of	of	IN
cord-018387-ci5wx26t	201	9	cytokine	cytokine	NN
cord-018387-ci5wx26t	201	10	production	production	NN
cord-018387-ci5wx26t	201	11	or	or	CC
cord-018387-ci5wx26t	201	12	adjuvant	adjuvant	JJ
cord-018387-ci5wx26t	201	13	effects	effect	NNS
cord-018387-ci5wx26t	201	14	on	on	IN
cord-018387-ci5wx26t	201	15	T	t	NN
cord-018387-ci5wx26t	201	16	-	-	HYPH
cord-018387-ci5wx26t	201	17	lymphocytes	lymphocyte	NNS
cord-018387-ci5wx26t	201	18	and	and	CC
cord-018387-ci5wx26t	201	19	NK	NK	NNP
cord-018387-ci5wx26t	201	20	activity	activity	NN
cord-018387-ci5wx26t	201	21	,	,	,
cord-018387-ci5wx26t	201	22	have	have	VBP
cord-018387-ci5wx26t	201	23	been	be	VBN
cord-018387-ci5wx26t	201	24	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	201	25	for	for	IN
cord-018387-ci5wx26t	201	26	various	various	JJ
cord-018387-ci5wx26t	201	27	health	health	NN
cord-018387-ci5wx26t	201	28	-	-	HYPH
cord-018387-ci5wx26t	201	29	promot-	promot-	NN
cord-018387-ci5wx26t	201	30	ing	ing	DT
cord-018387-ci5wx26t	201	31	Lactobacillus	lactobacillus	NN
cord-018387-ci5wx26t	201	32	and	and	CC
cord-018387-ci5wx26t	201	33	Bifidobacterium	bifidobacterium	NN
cord-018387-ci5wx26t	201	34	strains	strain	NNS
cord-018387-ci5wx26t	201	35	[	[	-LRB-
cord-018387-ci5wx26t	201	36	94	94	CD
cord-018387-ci5wx26t	201	37	]	]	-RRB-
cord-018387-ci5wx26t	201	38	[	[	-LRB-
cord-018387-ci5wx26t	201	39	95	95	CD
cord-018387-ci5wx26t	201	40	]	]	-RRB-
cord-018387-ci5wx26t	201	41	[	[	-LRB-
cord-018387-ci5wx26t	201	42	96	96	CD
cord-018387-ci5wx26t	201	43	]	]	-RRB-
cord-018387-ci5wx26t	201	44	.	.	.
cord-018387-ci5wx26t	202	1	It	-PRON-	PRP
cord-018387-ci5wx26t	202	2	has	have	VBZ
cord-018387-ci5wx26t	202	3	been	be	VBN
cord-018387-ci5wx26t	202	4	shown	show	VBN
cord-018387-ci5wx26t	202	5	that	that	IN
cord-018387-ci5wx26t	202	6	3-and	3-and	CD
cord-018387-ci5wx26t	202	7	6-week	6-week	CD
cord-018387-ci5wx26t	202	8	interventions	intervention	NNS
cord-018387-ci5wx26t	202	9	in	in	IN
cord-018387-ci5wx26t	202	10	elderly	elderly	JJ
cord-018387-ci5wx26t	202	11	people	people	NNS
cord-018387-ci5wx26t	202	12	can	can	MD
cord-018387-ci5wx26t	202	13	have	have	VB
cord-018387-ci5wx26t	202	14	positive	positive	JJ
cord-018387-ci5wx26t	202	15	effects	effect	NNS
cord-018387-ci5wx26t	202	16	,	,	,
cord-018387-ci5wx26t	202	17	such	such	JJ
cord-018387-ci5wx26t	202	18	as	as	IN
cord-018387-ci5wx26t	202	19	measurable	measurable	JJ
cord-018387-ci5wx26t	202	20	increases	increase	NNS
cord-018387-ci5wx26t	202	21	of	of	IN
cord-018387-ci5wx26t	202	22	NK	NK	NNP
cord-018387-ci5wx26t	202	23	cells	cell	NNS
cord-018387-ci5wx26t	202	24	,	,	,
cord-018387-ci5wx26t	202	25	tumoricidal	tumoricidal	JJ
cord-018387-ci5wx26t	202	26	activity	activity	NN
cord-018387-ci5wx26t	202	27	,	,	,
cord-018387-ci5wx26t	202	28	and	and	CC
cord-018387-ci5wx26t	202	29	monocyte	monocyte	NNP
cord-018387-ci5wx26t	202	30	phagocytic	phagocytic	JJ
cord-018387-ci5wx26t	202	31	capacity	capacity	NN
cord-018387-ci5wx26t	202	32	[	[	-LRB-
cord-018387-ci5wx26t	202	33	97	97	CD
cord-018387-ci5wx26t	202	34	]	]	-RRB-
cord-018387-ci5wx26t	202	35	.	.	.
cord-018387-ci5wx26t	203	1	A	a	DT
cord-018387-ci5wx26t	203	2	probiotic	probiotic	JJ
cord-018387-ci5wx26t	203	3	yogurt	yogurt	NN
cord-018387-ci5wx26t	203	4	supplementation	supplementation	NN
cord-018387-ci5wx26t	203	5	tested	test	VBN
cord-018387-ci5wx26t	203	6	on	on	IN
cord-018387-ci5wx26t	203	7	elderly	elderly	JJ
cord-018387-ci5wx26t	203	8	persons	person	NNS
cord-018387-ci5wx26t	203	9	affected	affect	VBD
cord-018387-ci5wx26t	203	10	intestinal	intestinal	JJ
cord-018387-ci5wx26t	203	11	bacterial	bacterial	JJ
cord-018387-ci5wx26t	203	12	overgrowth	overgrowth	NN
cord-018387-ci5wx26t	203	13	.	.	.
cord-018387-ci5wx26t	204	1	This	this	DT
cord-018387-ci5wx26t	204	2	intervention	intervention	NN
cord-018387-ci5wx26t	204	3	was	be	VBD
cord-018387-ci5wx26t	204	4	able	able	JJ
cord-018387-ci5wx26t	204	5	to	to	TO
cord-018387-ci5wx26t	204	6	normalize	normalize	VB
cord-018387-ci5wx26t	204	7	the	the	DT
cord-018387-ci5wx26t	204	8	response	response	NN
cord-018387-ci5wx26t	204	9	to	to	TO
cord-018387-ci5wx26t	204	10	endotoxin	endotoxin	NN
cord-018387-ci5wx26t	204	11	and	and	CC
cord-018387-ci5wx26t	204	12	modulate	modulate	VB
cord-018387-ci5wx26t	204	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	204	14	markers	marker	NNS
cord-018387-ci5wx26t	204	15	in	in	IN
cord-018387-ci5wx26t	204	16	blood	blood	NN
cord-018387-ci5wx26t	204	17	[	[	-LRB-
cord-018387-ci5wx26t	204	18	98	98	CD
cord-018387-ci5wx26t	204	19	]	]	-RRB-
cord-018387-ci5wx26t	204	20	as	as	RB
cord-018387-ci5wx26t	204	21	well	well	RB
cord-018387-ci5wx26t	204	22	as	as	IN
cord-018387-ci5wx26t	204	23	decrease	decrease	VB
cord-018387-ci5wx26t	204	24	the	the	DT
cord-018387-ci5wx26t	204	25	incidence	incidence	NN
cord-018387-ci5wx26t	204	26	of	of	IN
cord-018387-ci5wx26t	204	27	infections	infection	NNS
cord-018387-ci5wx26t	204	28	in	in	IN
cord-018387-ci5wx26t	204	29	this	this	DT
cord-018387-ci5wx26t	204	30	group	group	NN
cord-018387-ci5wx26t	204	31	of	of	IN
cord-018387-ci5wx26t	204	32	elderly	elderly	JJ
cord-018387-ci5wx26t	204	33	people	people	NNS
cord-018387-ci5wx26t	204	34	.	.	.
cord-018387-ci5wx26t	205	1	Furthermore	furthermore	RB
cord-018387-ci5wx26t	205	2	,	,	,
cord-018387-ci5wx26t	205	3	a	a	DT
cord-018387-ci5wx26t	205	4	significant	significant	JJ
cord-018387-ci5wx26t	205	5	increase	increase	NN
cord-018387-ci5wx26t	205	6	of	of	IN
cord-018387-ci5wx26t	205	7	phagocytosis	phagocytosis	NN
cord-018387-ci5wx26t	205	8	,	,	,
cord-018387-ci5wx26t	205	9	NK	nk	NN
cord-018387-ci5wx26t	205	10	-	-	HYPH
cord-018387-ci5wx26t	205	11	cell	cell	NN
cord-018387-ci5wx26t	205	12	activity	activity	NN
cord-018387-ci5wx26t	205	13	,	,	,
cord-018387-ci5wx26t	205	14	and	and	CC
cord-018387-ci5wx26t	205	15	production	production	NN
cord-018387-ci5wx26t	205	16	of	of	IN
cord-018387-ci5wx26t	205	17	IL-10	IL-10	NNP
cord-018387-ci5wx26t	205	18	was	be	VBD
cord-018387-ci5wx26t	205	19	also	also	RB
cord-018387-ci5wx26t	205	20	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	205	21	following	follow	VBG
cord-018387-ci5wx26t	205	22	the	the	DT
cord-018387-ci5wx26t	205	23	probiotic	probiotic	JJ
cord-018387-ci5wx26t	205	24	supplementation	supplementation	NN
cord-018387-ci5wx26t	205	25	in	in	IN
cord-018387-ci5wx26t	205	26	the	the	DT
cord-018387-ci5wx26t	205	27	elderly	elderly	JJ
cord-018387-ci5wx26t	205	28	as	as	RB
cord-018387-ci5wx26t	205	29	well	well	RB
cord-018387-ci5wx26t	205	30	as	as	IN
cord-018387-ci5wx26t	205	31	the	the	DT
cord-018387-ci5wx26t	205	32	reduced	reduce	VBN
cord-018387-ci5wx26t	205	33	production	production	NN
cord-018387-ci5wx26t	205	34	of	of	IN
cord-018387-ci5wx26t	205	35	the	the	DT
cord-018387-ci5wx26t	205	36	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	205	37	cytokines	cytokine	NNS
cord-018387-ci5wx26t	205	38	IL-6	IL-6	NNP
cord-018387-ci5wx26t	205	39	,	,	,
cord-018387-ci5wx26t	205	40	IL-1β	IL-1β	NNP
cord-018387-ci5wx26t	205	41	,	,	,
cord-018387-ci5wx26t	205	42	and	and	CC
cord-018387-ci5wx26t	205	43	TNF	TNF	NNP
cord-018387-ci5wx26t	205	44	[	[	-LRB-
cord-018387-ci5wx26t	205	45	92	92	CD
cord-018387-ci5wx26t	205	46	,	,	,
cord-018387-ci5wx26t	205	47	99	99	CD
cord-018387-ci5wx26t	205	48	]	]	-RRB-
cord-018387-ci5wx26t	205	49	.	.	.
cord-018387-ci5wx26t	206	1	Boge	Boge	NNP
cord-018387-ci5wx26t	206	2	et	et	NNP
cord-018387-ci5wx26t	206	3	al	al	NNP
cord-018387-ci5wx26t	206	4	.	.	.
cord-018387-ci5wx26t	207	1	showed	show	VBD
cord-018387-ci5wx26t	207	2	in	in	IN
cord-018387-ci5wx26t	207	3	two	two	CD
cord-018387-ci5wx26t	207	4	clinical	clinical	JJ
cord-018387-ci5wx26t	207	5	trials	trial	NNS
cord-018387-ci5wx26t	207	6	that	that	WDT
cord-018387-ci5wx26t	207	7	the	the	DT
cord-018387-ci5wx26t	207	8	consumption	consumption	NN
cord-018387-ci5wx26t	207	9	of	of	IN
cord-018387-ci5wx26t	207	10	a	a	DT
cord-018387-ci5wx26t	207	11	probiotic	probiotic	JJ
cord-018387-ci5wx26t	207	12	drink	drink	NN
cord-018387-ci5wx26t	207	13	(	(	-LRB-
cord-018387-ci5wx26t	207	14	containing	contain	VBG
cord-018387-ci5wx26t	207	15	L.	L.	NNP
cord-018387-ci5wx26t	207	16	casei	casei	NNP
cord-018387-ci5wx26t	207	17	)	)	-RRB-
cord-018387-ci5wx26t	207	18	by	by	IN
cord-018387-ci5wx26t	207	19	elderly	elderly	JJ
cord-018387-ci5wx26t	207	20	subjects	subject	NNS
cord-018387-ci5wx26t	207	21	for	for	IN
cord-018387-ci5wx26t	207	22	several	several	JJ
cord-018387-ci5wx26t	207	23	weeks	week	NNS
cord-018387-ci5wx26t	207	24	before	before	IN
cord-018387-ci5wx26t	207	25	and	and	CC
cord-018387-ci5wx26t	207	26	after	after	IN
cord-018387-ci5wx26t	207	27	an	an	DT
cord-018387-ci5wx26t	207	28	influenza	influenza	NN
cord-018387-ci5wx26t	207	29	vaccination	vaccination	NN
cord-018387-ci5wx26t	207	30	led	lead	VBD
cord-018387-ci5wx26t	207	31	to	to	IN
cord-018387-ci5wx26t	207	32	a	a	DT
cord-018387-ci5wx26t	207	33	significant	significant	JJ
cord-018387-ci5wx26t	207	34	increase	increase	NN
cord-018387-ci5wx26t	207	35	in	in	IN
cord-018387-ci5wx26t	207	36	the	the	DT
cord-018387-ci5wx26t	207	37	influenza	influenza	NN
cord-018387-ci5wx26t	207	38	-	-	HYPH
cord-018387-ci5wx26t	207	39	specific	specific	JJ
cord-018387-ci5wx26t	207	40	antibody	antibody	NN
cord-018387-ci5wx26t	207	41	titer	titer	NN
cord-018387-ci5wx26t	207	42	,	,	,
cord-018387-ci5wx26t	207	43	demonstrating	demonstrate	VBG
cord-018387-ci5wx26t	207	44	the	the	DT
cord-018387-ci5wx26t	207	45	potential	potential	NN
cord-018387-ci5wx26t	207	46	of	of	IN
cord-018387-ci5wx26t	207	47	probiotics	probiotic	NNS
cord-018387-ci5wx26t	207	48	in	in	IN
cord-018387-ci5wx26t	207	49	improving	improve	VBG
cord-018387-ci5wx26t	207	50	the	the	DT
cord-018387-ci5wx26t	207	51	protective	protective	JJ
cord-018387-ci5wx26t	207	52	efficacy	efficacy	NN
cord-018387-ci5wx26t	207	53	of	of	IN
cord-018387-ci5wx26t	207	54	vaccination	vaccination	NN
cord-018387-ci5wx26t	207	55	in	in	IN
cord-018387-ci5wx26t	207	56	the	the	DT
cord-018387-ci5wx26t	207	57	elderly	elderly	JJ
cord-018387-ci5wx26t	207	58	population	population	NN
cord-018387-ci5wx26t	207	59	,	,	,
cord-018387-ci5wx26t	207	60	in	in	IN
cord-018387-ci5wx26t	207	61	which	which	WDT
cord-018387-ci5wx26t	207	62	it	-PRON-	PRP
cord-018387-ci5wx26t	207	63	is	be	VBZ
cord-018387-ci5wx26t	207	64	usually	usually	RB
cord-018387-ci5wx26t	207	65	considerably	considerably	RB
cord-018387-ci5wx26t	207	66	reduced	reduce	VBN
cord-018387-ci5wx26t	207	67	[	[	-LRB-
cord-018387-ci5wx26t	207	68	100	100	CD
cord-018387-ci5wx26t	207	69	,	,	,
cord-018387-ci5wx26t	207	70	101	101	CD
cord-018387-ci5wx26t	207	71	]	]	-RRB-
cord-018387-ci5wx26t	207	72	.	.	.
cord-018387-ci5wx26t	208	1	A	a	DT
cord-018387-ci5wx26t	208	2	seminal	seminal	JJ
cord-018387-ci5wx26t	208	3	advance	advance	NN
cord-018387-ci5wx26t	208	4	has	have	VBZ
cord-018387-ci5wx26t	208	5	been	be	VBN
cord-018387-ci5wx26t	208	6	the	the	DT
cord-018387-ci5wx26t	208	7	realization	realization	NN
cord-018387-ci5wx26t	208	8	that	that	IN
cord-018387-ci5wx26t	208	9	probiotic	probiotic	JJ
cord-018387-ci5wx26t	208	10	supplementation	supplementation	NN
cord-018387-ci5wx26t	208	11	is	be	VBZ
cord-018387-ci5wx26t	208	12	likely	likely	JJ
cord-018387-ci5wx26t	208	13	to	to	TO
cord-018387-ci5wx26t	208	14	require	require	VB
cord-018387-ci5wx26t	208	15	"	"	``
cord-018387-ci5wx26t	208	16	tailor	tailor	NN
cord-018387-ci5wx26t	208	17	-	-	HYPH
cord-018387-ci5wx26t	208	18	made	make	VBN
cord-018387-ci5wx26t	208	19	"	"	``
cord-018387-ci5wx26t	208	20	mixtures	mixture	NNS
cord-018387-ci5wx26t	208	21	of	of	IN
cord-018387-ci5wx26t	208	22	different	different	JJ
cord-018387-ci5wx26t	208	23	bacteria	bacteria	NNS
cord-018387-ci5wx26t	208	24	in	in	IN
cord-018387-ci5wx26t	208	25	order	order	NN
cord-018387-ci5wx26t	208	26	to	to	TO
cord-018387-ci5wx26t	208	27	achieve	achieve	VB
cord-018387-ci5wx26t	208	28	the	the	DT
cord-018387-ci5wx26t	208	29	desired	desire	VBN
cord-018387-ci5wx26t	208	30	effect	effect	NN
cord-018387-ci5wx26t	208	31	.	.	.
cord-018387-ci5wx26t	209	1	Atarashi	Atarashi	NNP
cord-018387-ci5wx26t	209	2	et	et	FW
cord-018387-ci5wx26t	209	3	al	al	NNP
cord-018387-ci5wx26t	209	4	.	.	NNP
cord-018387-ci5wx26t	209	5	identified	identify	VBD
cord-018387-ci5wx26t	209	6	17	17	CD
cord-018387-ci5wx26t	209	7	strains	strain	NNS
cord-018387-ci5wx26t	209	8	of	of	IN
cord-018387-ci5wx26t	209	9	bacteria	bacteria	NNS
cord-018387-ci5wx26t	209	10	preferentially	preferentially	RB
cord-018387-ci5wx26t	209	11	inducing	induce	VBG
cord-018387-ci5wx26t	209	12	colonic	colonic	JJ
cord-018387-ci5wx26t	209	13	Tregs	Tregs	NNP
cord-018387-ci5wx26t	209	14	which	which	WDT
cord-018387-ci5wx26t	209	15	reduced	reduce	VBD
cord-018387-ci5wx26t	209	16	symptoms	symptom	NNS
cord-018387-ci5wx26t	209	17	in	in	IN
cord-018387-ci5wx26t	209	18	models	model	NNS
cord-018387-ci5wx26t	209	19	of	of	IN
cord-018387-ci5wx26t	209	20	colitis	colitis	NN
cord-018387-ci5wx26t	209	21	and	and	CC
cord-018387-ci5wx26t	209	22	allergic	allergic	JJ
cord-018387-ci5wx26t	209	23	diarrhea	diarrhea	NN
cord-018387-ci5wx26t	209	24	in	in	IN
cord-018387-ci5wx26t	209	25	mice	mouse	NNS
cord-018387-ci5wx26t	209	26	[	[	-LRB-
cord-018387-ci5wx26t	209	27	102	102	CD
cord-018387-ci5wx26t	209	28	]	]	-RRB-
cord-018387-ci5wx26t	209	29	.	.	.
cord-018387-ci5wx26t	210	1	Thus	thus	RB
cord-018387-ci5wx26t	210	2	,	,	,
cord-018387-ci5wx26t	210	3	supplementation	supplementation	NN
cord-018387-ci5wx26t	210	4	with	with	IN
cord-018387-ci5wx26t	210	5	tailor	tailor	NN
cord-018387-ci5wx26t	210	6	-	-	HYPH
cord-018387-ci5wx26t	210	7	made	make	VBN
cord-018387-ci5wx26t	210	8	mixtures	mixture	NNS
cord-018387-ci5wx26t	210	9	of	of	IN
cord-018387-ci5wx26t	210	10	probiotics	probiotic	NNS
cord-018387-ci5wx26t	210	11	may	may	MD
cord-018387-ci5wx26t	210	12	be	be	VB
cord-018387-ci5wx26t	210	13	effective	effective	JJ
cord-018387-ci5wx26t	210	14	in	in	IN
cord-018387-ci5wx26t	210	15	modulating	modulate	VBG
cord-018387-ci5wx26t	210	16	immune	immune	JJ
cord-018387-ci5wx26t	210	17	responses	response	NNS
cord-018387-ci5wx26t	210	18	where	where	WRB
cord-018387-ci5wx26t	210	19	the	the	DT
cord-018387-ci5wx26t	210	20	use	use	NN
cord-018387-ci5wx26t	210	21	of	of	IN
cord-018387-ci5wx26t	210	22	single	single	JJ
cord-018387-ci5wx26t	210	23	strains	strain	NNS
cord-018387-ci5wx26t	210	24	is	be	VBZ
cord-018387-ci5wx26t	210	25	ineffective	ineffective	JJ
cord-018387-ci5wx26t	210	26	.	.	.
cord-018387-ci5wx26t	211	1	This	this	DT
cord-018387-ci5wx26t	211	2	may	may	MD
cord-018387-ci5wx26t	211	3	be	be	VB
cord-018387-ci5wx26t	211	4	one	one	CD
cord-018387-ci5wx26t	211	5	reason	reason	NN
cord-018387-ci5wx26t	211	6	why	why	WRB
cord-018387-ci5wx26t	211	7	the	the	DT
cord-018387-ci5wx26t	211	8	results	result	NNS
cord-018387-ci5wx26t	211	9	of	of	IN
cord-018387-ci5wx26t	211	10	the	the	DT
cord-018387-ci5wx26t	211	11	many	many	JJ
cord-018387-ci5wx26t	211	12	human	human	JJ
cord-018387-ci5wx26t	211	13	probiotics	probiotic	NNS
cord-018387-ci5wx26t	211	14	supplementation	supplementation	NN
cord-018387-ci5wx26t	211	15	trials	trial	NNS
cord-018387-ci5wx26t	211	16	have	have	VBP
cord-018387-ci5wx26t	211	17	often	often	RB
cord-018387-ci5wx26t	211	18	been	be	VBN
cord-018387-ci5wx26t	211	19	equivocal	equivocal	JJ
cord-018387-ci5wx26t	211	20	since	since	IN
cord-018387-ci5wx26t	211	21	mostly	mostly	RB
cord-018387-ci5wx26t	211	22	a	a	DT
cord-018387-ci5wx26t	211	23	single	single	JJ
cord-018387-ci5wx26t	211	24	strain	strain	NN
cord-018387-ci5wx26t	211	25	was	be	VBD
cord-018387-ci5wx26t	211	26	used	use	VBN
cord-018387-ci5wx26t	211	27	even	even	RB
cord-018387-ci5wx26t	211	28	if	if	IN
cord-018387-ci5wx26t	211	29	it	-PRON-	PRP
cord-018387-ci5wx26t	211	30	was	be	VBD
cord-018387-ci5wx26t	211	31	the	the	DT
cord-018387-ci5wx26t	211	32	"	"	``
cord-018387-ci5wx26t	211	33	right	right	JJ
cord-018387-ci5wx26t	211	34	"	"	''
cord-018387-ci5wx26t	211	35	strain	strain	NN
cord-018387-ci5wx26t	211	36	[	[	-LRB-
cord-018387-ci5wx26t	211	37	2	2	CD
cord-018387-ci5wx26t	211	38	]	]	-RRB-
cord-018387-ci5wx26t	211	39	.	.	.
cord-018387-ci5wx26t	212	1	The	the	DT
cord-018387-ci5wx26t	212	2	mechanism	mechanism	NN
cord-018387-ci5wx26t	212	3	of	of	IN
cord-018387-ci5wx26t	212	4	action	action	NN
cord-018387-ci5wx26t	212	5	of	of	IN
cord-018387-ci5wx26t	212	6	the	the	DT
cord-018387-ci5wx26t	212	7	mixed	mixed	JJ
cord-018387-ci5wx26t	212	8	bacterial	bacterial	JJ
cord-018387-ci5wx26t	212	9	strains	strain	NNS
cord-018387-ci5wx26t	212	10	is	be	VBZ
cord-018387-ci5wx26t	212	11	the	the	DT
cord-018387-ci5wx26t	212	12	induction	induction	NN
cord-018387-ci5wx26t	212	13	of	of	IN
cord-018387-ci5wx26t	212	14	CD4	CD4	NNP
cord-018387-ci5wx26t	212	15	+	+	CC
cord-018387-ci5wx26t	212	16	CD25	CD25	NNP
cord-018387-ci5wx26t	212	17	+	+	CC
cord-018387-ci5wx26t	212	18	FOXP3	foxp3	NN
cord-018387-ci5wx26t	213	1	+	+	CC
cord-018387-ci5wx26t	214	1	Tregs	treg	NNS
cord-018387-ci5wx26t	214	2	by	by	IN
cord-018387-ci5wx26t	214	3	bacterial	bacterial	JJ
cord-018387-ci5wx26t	214	4	antigens	antigen	NNS
cord-018387-ci5wx26t	214	5	,	,	,
cord-018387-ci5wx26t	214	6	which	which	WDT
cord-018387-ci5wx26t	214	7	in	in	IN
cord-018387-ci5wx26t	214	8	turn	turn	NN
cord-018387-ci5wx26t	214	9	stimulate	stimulate	VBP
cord-018387-ci5wx26t	214	10	the	the	DT
cord-018387-ci5wx26t	214	11	intestinal	intestinal	JJ
cord-018387-ci5wx26t	214	12	epithelial	epithelial	JJ
cord-018387-ci5wx26t	214	13	cells	cell	NNS
cord-018387-ci5wx26t	214	14	to	to	TO
cord-018387-ci5wx26t	214	15	produce	produce	VB
cord-018387-ci5wx26t	214	16	TGF	TGF	NNP
cord-018387-ci5wx26t	214	17	-	-	HYPH
cord-018387-ci5wx26t	214	18	ß1	ß1	NNP
cord-018387-ci5wx26t	214	19	,	,	,
cord-018387-ci5wx26t	214	20	but	but	CC
cord-018387-ci5wx26t	214	21	not	not	RB
cord-018387-ci5wx26t	214	22	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	214	23	IL-6	IL-6	NNP
cord-018387-ci5wx26t	214	24	,	,	,
cord-018387-ci5wx26t	214	25	and	and	CC
cord-018387-ci5wx26t	214	26	TNF	TNF	NNP
cord-018387-ci5wx26t	214	27	.	.	.
cord-018387-ci5wx26t	215	1	Fecal	fecal	JJ
cord-018387-ci5wx26t	215	2	samples	sample	NNS
cord-018387-ci5wx26t	215	3	from	from	IN
cord-018387-ci5wx26t	215	4	patients	patient	NNS
cord-018387-ci5wx26t	215	5	with	with	IN
cord-018387-ci5wx26t	215	6	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	215	7	bowel	bowel	NN
cord-018387-ci5wx26t	215	8	disease	disease	NN
cord-018387-ci5wx26t	215	9	and	and	CC
cord-018387-ci5wx26t	215	10	atopy	atopy	NN
cord-018387-ci5wx26t	215	11	have	have	VBP
cord-018387-ci5wx26t	215	12	been	be	VBN
cord-018387-ci5wx26t	215	13	reported	report	VBN
cord-018387-ci5wx26t	215	14	to	to	TO
cord-018387-ci5wx26t	215	15	contain	contain	VB
cord-018387-ci5wx26t	215	16	relatively	relatively	RB
cord-018387-ci5wx26t	215	17	low	low	JJ
cord-018387-ci5wx26t	215	18	amounts	amount	NNS
cord-018387-ci5wx26t	215	19	of	of	IN
cord-018387-ci5wx26t	215	20	some	some	DT
cord-018387-ci5wx26t	215	21	of	of	IN
cord-018387-ci5wx26t	215	22	the	the	DT
cord-018387-ci5wx26t	215	23	same	same	JJ
cord-018387-ci5wx26t	215	24	bacterial	bacterial	JJ
cord-018387-ci5wx26t	215	25	strains	strain	NNS
cord-018387-ci5wx26t	215	26	,	,	,
cord-018387-ci5wx26t	215	27	suggesting	suggest	VBG
cord-018387-ci5wx26t	215	28	their	-PRON-	PRP$
cord-018387-ci5wx26t	215	29	relevance	relevance	NN
cord-018387-ci5wx26t	215	30	to	to	IN
cord-018387-ci5wx26t	215	31	human	human	JJ
cord-018387-ci5wx26t	215	32	disease	disease	NN
cord-018387-ci5wx26t	215	33	as	as	RB
cord-018387-ci5wx26t	215	34	well	well	RB
cord-018387-ci5wx26t	215	35	as	as	IN
cord-018387-ci5wx26t	215	36	in	in	IN
cord-018387-ci5wx26t	215	37	the	the	DT
cord-018387-ci5wx26t	215	38	animal	animal	NN
cord-018387-ci5wx26t	215	39	model	model	NN
cord-018387-ci5wx26t	215	40	.	.	.
cord-018387-ci5wx26t	216	1	In	in	IN
cord-018387-ci5wx26t	216	2	the	the	DT
cord-018387-ci5wx26t	216	3	context	context	NN
cord-018387-ci5wx26t	216	4	of	of	IN
cord-018387-ci5wx26t	216	5	supporting	support	VBG
cord-018387-ci5wx26t	216	6	the	the	DT
cord-018387-ci5wx26t	216	7	"	"	``
cord-018387-ci5wx26t	216	8	right	right	JJ
cord-018387-ci5wx26t	216	9	"	"	''
cord-018387-ci5wx26t	216	10	balance	balance	NN
cord-018387-ci5wx26t	216	11	of	of	IN
cord-018387-ci5wx26t	216	12	gut	gut	NN
cord-018387-ci5wx26t	216	13	bacteria	bacteria	NNS
cord-018387-ci5wx26t	216	14	,	,	,
cord-018387-ci5wx26t	216	15	reversing	reverse	VBG
cord-018387-ci5wx26t	216	16	our	-PRON-	PRP$
cord-018387-ci5wx26t	216	17	nutritional	nutritional	JJ
cord-018387-ci5wx26t	216	18	habits	habit	NNS
cord-018387-ci5wx26t	216	19	"	"	''
cord-018387-ci5wx26t	216	20	back	back	RB
cord-018387-ci5wx26t	216	21	to	to	IN
cord-018387-ci5wx26t	216	22	mother	mother	NN
cord-018387-ci5wx26t	216	23	nature	nature	NN
cord-018387-ci5wx26t	216	24	"	"	''
cord-018387-ci5wx26t	216	25	might	may	MD
cord-018387-ci5wx26t	216	26	represent	represent	VB
cord-018387-ci5wx26t	216	27	an	an	DT
cord-018387-ci5wx26t	216	28	additional	additional	JJ
cord-018387-ci5wx26t	216	29	solution	solution	NN
cord-018387-ci5wx26t	216	30	for	for	IN
cord-018387-ci5wx26t	216	31	the	the	DT
cord-018387-ci5wx26t	216	32	modulation	modulation	NN
cord-018387-ci5wx26t	216	33	of	of	IN
cord-018387-ci5wx26t	216	34	agerelated	agerelate	VBN
cord-018387-ci5wx26t	216	35	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	216	36	status	status	NN
cord-018387-ci5wx26t	216	37	and	and	CC
cord-018387-ci5wx26t	216	38	associated	associated	JJ
cord-018387-ci5wx26t	216	39	chronic	chronic	NN
cord-018387-ci5wx26t	216	40	and	and	CC
cord-018387-ci5wx26t	216	41	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	216	42	diseases	disease	NNS
cord-018387-ci5wx26t	216	43	[	[	-LRB-
cord-018387-ci5wx26t	216	44	2	2	CD
cord-018387-ci5wx26t	216	45	]	]	-RRB-
cord-018387-ci5wx26t	216	46	.	.	.
cord-018387-ci5wx26t	217	1	The	the	DT
cord-018387-ci5wx26t	217	2	accumulating	accumulate	VBG
cord-018387-ci5wx26t	217	3	data	datum	NNS
cord-018387-ci5wx26t	217	4	from	from	IN
cord-018387-ci5wx26t	217	5	in	in	IN
cord-018387-ci5wx26t	217	6	vitro	vitro	FW
cord-018387-ci5wx26t	217	7	,	,	,
cord-018387-ci5wx26t	217	8	animal	animal	NN
cord-018387-ci5wx26t	217	9	,	,	,
cord-018387-ci5wx26t	217	10	and	and	CC
cord-018387-ci5wx26t	217	11	clinical	clinical	JJ
cord-018387-ci5wx26t	217	12	studies	study	NNS
cord-018387-ci5wx26t	217	13	provide	provide	VBP
cord-018387-ci5wx26t	217	14	evidence	evidence	NN
cord-018387-ci5wx26t	217	15	that	that	IN
cord-018387-ci5wx26t	217	16	a	a	DT
cord-018387-ci5wx26t	217	17	greater	great	JJR
cord-018387-ci5wx26t	217	18	consumption	consumption	NN
cord-018387-ci5wx26t	217	19	of	of	IN
cord-018387-ci5wx26t	217	20	fruits	fruit	NNS
cord-018387-ci5wx26t	217	21	,	,	,
cord-018387-ci5wx26t	217	22	cereals	cereal	NNS
cord-018387-ci5wx26t	217	23	,	,	,
cord-018387-ci5wx26t	217	24	vegetables	vegetable	NNS
cord-018387-ci5wx26t	217	25	,	,	,
cord-018387-ci5wx26t	217	26	legumes	legume	NNS
cord-018387-ci5wx26t	217	27	,	,	,
cord-018387-ci5wx26t	217	28	and	and	CC
cord-018387-ci5wx26t	217	29	spices	spice	NNS
cord-018387-ci5wx26t	217	30	is	be	VBZ
cord-018387-ci5wx26t	217	31	associated	associate	VBN
cord-018387-ci5wx26t	217	32	with	with	IN
cord-018387-ci5wx26t	217	33	a	a	DT
cord-018387-ci5wx26t	217	34	lower	low	JJR
cord-018387-ci5wx26t	217	35	risk	risk	NN
cord-018387-ci5wx26t	217	36	of	of	IN
cord-018387-ci5wx26t	217	37	many	many	JJ
cord-018387-ci5wx26t	217	38	diseases	disease	NNS
cord-018387-ci5wx26t	217	39	[	[	-LRB-
cord-018387-ci5wx26t	217	40	103	103	CD
cord-018387-ci5wx26t	217	41	]	]	-RRB-
cord-018387-ci5wx26t	217	42	[	[	-LRB-
cord-018387-ci5wx26t	217	43	104	104	CD
cord-018387-ci5wx26t	217	44	]	]	-RRB-
cord-018387-ci5wx26t	217	45	[	[	-LRB-
cord-018387-ci5wx26t	217	46	105	105	CD
cord-018387-ci5wx26t	217	47	]	]	-RRB-
cord-018387-ci5wx26t	217	48	[	[	-LRB-
cord-018387-ci5wx26t	217	49	106	106	CD
cord-018387-ci5wx26t	217	50	]	]	-RRB-
cord-018387-ci5wx26t	217	51	[	[	-LRB-
cord-018387-ci5wx26t	217	52	107	107	CD
cord-018387-ci5wx26t	217	53	]	]	-RRB-
cord-018387-ci5wx26t	217	54	[	[	-LRB-
cord-018387-ci5wx26t	217	55	108	108	CD
cord-018387-ci5wx26t	217	56	]	]	-RRB-
cord-018387-ci5wx26t	217	57	.	.	.
cord-018387-ci5wx26t	218	1	Consumption	consumption	NN
cord-018387-ci5wx26t	218	2	of	of	IN
cord-018387-ci5wx26t	218	3	diets	diet	NNS
cord-018387-ci5wx26t	218	4	consisting	consist	VBG
cord-018387-ci5wx26t	218	5	of	of	IN
cord-018387-ci5wx26t	218	6	natural	natural	JJ
cord-018387-ci5wx26t	218	7	foods	food	NNS
cord-018387-ci5wx26t	218	8	can	can	MD
cord-018387-ci5wx26t	218	9	also	also	RB
cord-018387-ci5wx26t	218	10	raise	raise	VB
cord-018387-ci5wx26t	218	11	the	the	DT
cord-018387-ci5wx26t	218	12	amounts	amount	NNS
cord-018387-ci5wx26t	218	13	of	of	IN
cord-018387-ci5wx26t	218	14	plant	plant	NN
cord-018387-ci5wx26t	218	15	-	-	HYPH
cord-018387-ci5wx26t	218	16	based	base	VBN
cord-018387-ci5wx26t	218	17	nutraceuticals	nutraceutical	NNS
cord-018387-ci5wx26t	218	18	in	in	IN
cord-018387-ci5wx26t	218	19	the	the	DT
cord-018387-ci5wx26t	218	20	body	body	NN
cord-018387-ci5wx26t	218	21	,	,	,
cord-018387-ci5wx26t	218	22	such	such	JJ
cord-018387-ci5wx26t	218	23	as	as	IN
cord-018387-ci5wx26t	218	24	antioxidants	antioxidant	NNS
cord-018387-ci5wx26t	218	25	and	and	CC
cord-018387-ci5wx26t	218	26	anti	anti	JJ
cord-018387-ci5wx26t	218	27	-	-	JJ
cord-018387-ci5wx26t	218	28	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	218	29	agents	agent	NNS
cord-018387-ci5wx26t	218	30	.	.	.
cord-018387-ci5wx26t	219	1	These	these	DT
cord-018387-ci5wx26t	219	2	nutraceuticals	nutraceutical	NNS
cord-018387-ci5wx26t	219	3	are	be	VBP
cord-018387-ci5wx26t	219	4	known	know	VBN
cord-018387-ci5wx26t	219	5	to	to	TO
cord-018387-ci5wx26t	219	6	cope	cope	VB
cord-018387-ci5wx26t	219	7	with	with	IN
cord-018387-ci5wx26t	219	8	free	free	JJ
cord-018387-ci5wx26t	219	9	radicals	radical	NNS
cord-018387-ci5wx26t	219	10	and	and	CC
cord-018387-ci5wx26t	219	11	to	to	TO
cord-018387-ci5wx26t	219	12	modulate	modulate	VB
cord-018387-ci5wx26t	219	13	the	the	DT
cord-018387-ci5wx26t	219	14	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	219	15	signaling	signal	VBG
cord-018387-ci5wx26t	219	16	pathways	pathway	NNS
cord-018387-ci5wx26t	219	17	in	in	IN
cord-018387-ci5wx26t	219	18	cells	cell	NNS
cord-018387-ci5wx26t	219	19	,	,	,
cord-018387-ci5wx26t	219	20	suppressing	suppress	VBG
cord-018387-ci5wx26t	219	21	the	the	DT
cord-018387-ci5wx26t	219	22	onset	onset	NN
cord-018387-ci5wx26t	219	23	of	of	IN
cord-018387-ci5wx26t	219	24	age	age	NN
cord-018387-ci5wx26t	219	25	-	-	HYPH
cord-018387-ci5wx26t	219	26	related	relate	VBN
cord-018387-ci5wx26t	219	27	chronic	chronic	JJ
cord-018387-ci5wx26t	219	28	conditions	condition	NNS
cord-018387-ci5wx26t	219	29	[	[	-LRB-
cord-018387-ci5wx26t	219	30	2	2	CD
cord-018387-ci5wx26t	219	31	,	,	,
cord-018387-ci5wx26t	219	32	107	107	CD
cord-018387-ci5wx26t	219	33	,	,	,
cord-018387-ci5wx26t	219	34	[	[	-LRB-
cord-018387-ci5wx26t	219	35	109	109	CD
cord-018387-ci5wx26t	219	36	]	]	-RRB-
cord-018387-ci5wx26t	219	37	[	[	-LRB-
cord-018387-ci5wx26t	219	38	110	110	CD
cord-018387-ci5wx26t	219	39	]	]	-RRB-
cord-018387-ci5wx26t	219	40	[	[	-LRB-
cord-018387-ci5wx26t	219	41	111	111	CD
cord-018387-ci5wx26t	219	42	]	]	-RRB-
cord-018387-ci5wx26t	219	43	.	.	.
cord-018387-ci5wx26t	220	1	Several	several	JJ
cord-018387-ci5wx26t	220	2	studies	study	NNS
cord-018387-ci5wx26t	220	3	demonstrate	demonstrate	VBP
cord-018387-ci5wx26t	220	4	that	that	IN
cord-018387-ci5wx26t	220	5	dietary	dietary	JJ
cord-018387-ci5wx26t	220	6	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	220	7	are	be	VBP
cord-018387-ci5wx26t	220	8	able	able	JJ
cord-018387-ci5wx26t	220	9	to	to	TO
cord-018387-ci5wx26t	220	10	repress	repress	VB
cord-018387-ci5wx26t	220	11	inflammation	inflammation	NN
cord-018387-ci5wx26t	220	12	by	by	IN
cord-018387-ci5wx26t	220	13	the	the	DT
cord-018387-ci5wx26t	220	14	inhibition	inhibition	NN
cord-018387-ci5wx26t	220	15	of	of	IN
cord-018387-ci5wx26t	220	16	nuclear	nuclear	JJ
cord-018387-ci5wx26t	220	17	factor	factor	NN
cord-018387-ci5wx26t	220	18	kappa	kappa	NN
cord-018387-ci5wx26t	220	19	-	-	HYPH
cord-018387-ci5wx26t	220	20	light	light	JJ
cord-018387-ci5wx26t	220	21	-	-	HYPH
cord-018387-ci5wx26t	220	22	chain	chain	NN
cord-018387-ci5wx26t	220	23	enhancer	enhancer	NN
cord-018387-ci5wx26t	220	24	of	of	IN
cord-018387-ci5wx26t	220	25	activated	activate	VBN
cord-018387-ci5wx26t	220	26	B	b	NN
cord-018387-ci5wx26t	220	27	-	-	HYPH
cord-018387-ci5wx26t	220	28	cell	cell	NN
cord-018387-ci5wx26t	220	29	(	(	-LRB-
cord-018387-ci5wx26t	220	30	NF	nf	NN
cord-018387-ci5wx26t	220	31	-	-	HYPH
cord-018387-ci5wx26t	220	32	κB	κB	NNP
cord-018387-ci5wx26t	220	33	)	)	-RRB-
cord-018387-ci5wx26t	220	34	signaling	signal	VBG
cord-018387-ci5wx26t	220	35	[	[	-LRB-
cord-018387-ci5wx26t	220	36	112	112	CD
cord-018387-ci5wx26t	220	37	]	]	-RRB-
cord-018387-ci5wx26t	220	38	[	[	-LRB-
cord-018387-ci5wx26t	220	39	113	113	CD
cord-018387-ci5wx26t	220	40	]	]	-RRB-
cord-018387-ci5wx26t	220	41	[	[	-LRB-
cord-018387-ci5wx26t	220	42	114	114	CD
cord-018387-ci5wx26t	220	43	]	]	-RRB-
cord-018387-ci5wx26t	220	44	[	[	-LRB-
cord-018387-ci5wx26t	220	45	115	115	CD
cord-018387-ci5wx26t	220	46	]	]	-RRB-
cord-018387-ci5wx26t	220	47	[	[	-LRB-
cord-018387-ci5wx26t	220	48	116	116	CD
cord-018387-ci5wx26t	220	49	]	]	-RRB-
cord-018387-ci5wx26t	220	50	.	.	.
cord-018387-ci5wx26t	221	1	Remarkably	remarkably	RB
cord-018387-ci5wx26t	221	2	,	,	,
cord-018387-ci5wx26t	221	3	plant	plant	NN
cord-018387-ci5wx26t	221	4	extracts	extract	NNS
cord-018387-ci5wx26t	221	5	from	from	IN
cord-018387-ci5wx26t	221	6	strawberry	strawberry	NN
cord-018387-ci5wx26t	221	7	,	,	,
cord-018387-ci5wx26t	221	8	mulberry	mulberry	NN
cord-018387-ci5wx26t	221	9	,	,	,
cord-018387-ci5wx26t	221	10	and	and	CC
cord-018387-ci5wx26t	221	11	blueberry	blueberry	NN
cord-018387-ci5wx26t	221	12	were	be	VBD
cord-018387-ci5wx26t	221	13	shown	show	VBN
cord-018387-ci5wx26t	221	14	to	to	TO
cord-018387-ci5wx26t	221	15	contain	contain	VB
cord-018387-ci5wx26t	221	16	antioxidants	antioxidant	NNS
cord-018387-ci5wx26t	221	17	that	that	WDT
cord-018387-ci5wx26t	221	18	are	be	VBP
cord-018387-ci5wx26t	221	19	able	able	JJ
cord-018387-ci5wx26t	221	20	to	to	TO
cord-018387-ci5wx26t	221	21	activate	activate	VB
cord-018387-ci5wx26t	221	22	the	the	DT
cord-018387-ci5wx26t	221	23	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	221	24	defense	defense	NN
cord-018387-ci5wx26t	221	25	system	system	NN
cord-018387-ci5wx26t	221	26	and	and	CC
cord-018387-ci5wx26t	221	27	to	to	TO
cord-018387-ci5wx26t	221	28	counter	counter	VB
cord-018387-ci5wx26t	221	29	the	the	DT
cord-018387-ci5wx26t	221	30	deleterious	deleterious	JJ
cord-018387-ci5wx26t	221	31	effects	effect	NNS
cord-018387-ci5wx26t	221	32	of	of	IN
cord-018387-ci5wx26t	221	33	irradiation	irradiation	NN
cord-018387-ci5wx26t	221	34	by	by	IN
cord-018387-ci5wx26t	221	35	reducing	reduce	VBG
cord-018387-ci5wx26t	221	36	oxidative	oxidative	JJ
cord-018387-ci5wx26t	221	37	stress	stress	NN
cord-018387-ci5wx26t	221	38	and	and	CC
cord-018387-ci5wx26t	221	39	inflammation	inflammation	NN
cord-018387-ci5wx26t	221	40	[	[	-LRB-
cord-018387-ci5wx26t	221	41	117	117	CD
cord-018387-ci5wx26t	221	42	]	]	-RRB-
cord-018387-ci5wx26t	221	43	.	.	.
cord-018387-ci5wx26t	222	1	A	a	DT
cord-018387-ci5wx26t	222	2	significant	significant	JJ
cord-018387-ci5wx26t	222	3	decrease	decrease	NN
cord-018387-ci5wx26t	222	4	in	in	IN
cord-018387-ci5wx26t	222	5	the	the	DT
cord-018387-ci5wx26t	222	6	levels	level	NNS
cord-018387-ci5wx26t	222	7	of	of	IN
cord-018387-ci5wx26t	222	8	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	222	9	cytokines	cytokine	NNS
cord-018387-ci5wx26t	222	10	was	be	VBD
cord-018387-ci5wx26t	222	11	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	222	12	by	by	IN
cord-018387-ci5wx26t	222	13	the	the	DT
cord-018387-ci5wx26t	222	14	administration	administration	NN
cord-018387-ci5wx26t	222	15	of	of	IN
cord-018387-ci5wx26t	222	16	the	the	DT
cord-018387-ci5wx26t	222	17	diet	diet	NN
cord-018387-ci5wx26t	222	18	supplements	supplement	NNS
cord-018387-ci5wx26t	222	19	containing	contain	VBG
cord-018387-ci5wx26t	222	20	pomegranates	pomegranate	NNS
cord-018387-ci5wx26t	222	21	,	,	,
cord-018387-ci5wx26t	222	22	figs	fig	NNS
cord-018387-ci5wx26t	222	23	,	,	,
cord-018387-ci5wx26t	222	24	or	or	CC
cord-018387-ci5wx26t	222	25	dates	date	VBZ
cord-018387-ci5wx26t	222	26	[	[	-LRB-
cord-018387-ci5wx26t	222	27	118	118	CD
cord-018387-ci5wx26t	222	28	]	]	-RRB-
cord-018387-ci5wx26t	222	29	.	.	.
cord-018387-ci5wx26t	223	1	Nutritional	nutritional	JJ
cord-018387-ci5wx26t	223	2	intervention	intervention	NN
cord-018387-ci5wx26t	223	3	including	include	VBG
cord-018387-ci5wx26t	223	4	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	223	5	and	and	CC
cord-018387-ci5wx26t	223	6	vitamins	vitamin	NNS
cord-018387-ci5wx26t	223	7	has	have	VBZ
cord-018387-ci5wx26t	223	8	also	also	RB
cord-018387-ci5wx26t	223	9	been	be	VBN
cord-018387-ci5wx26t	223	10	recognized	recognize	VBN
cord-018387-ci5wx26t	223	11	as	as	IN
cord-018387-ci5wx26t	223	12	a	a	DT
cord-018387-ci5wx26t	223	13	practical	practical	JJ
cord-018387-ci5wx26t	223	14	,	,	,
cord-018387-ci5wx26t	223	15	cost	cost	NN
cord-018387-ci5wx26t	223	16	-	-	HYPH
cord-018387-ci5wx26t	223	17	effective	effective	JJ
cord-018387-ci5wx26t	223	18	approach	approach	NN
cord-018387-ci5wx26t	223	19	to	to	TO
cord-018387-ci5wx26t	223	20	attenuate	attenuate	VB
cord-018387-ci5wx26t	223	21	age	age	NN
cord-018387-ci5wx26t	223	22	-	-	HYPH
cord-018387-ci5wx26t	223	23	associated	associate	VBN
cord-018387-ci5wx26t	223	24	declines	decline	NNS
cord-018387-ci5wx26t	223	25	in	in	IN
cord-018387-ci5wx26t	223	26	immune	immune	JJ
cord-018387-ci5wx26t	223	27	function	function	NN
cord-018387-ci5wx26t	223	28	,	,	,
cord-018387-ci5wx26t	223	29	vaccination	vaccination	NN
cord-018387-ci5wx26t	223	30	efficiency	efficiency	NN
cord-018387-ci5wx26t	223	31	,	,	,
cord-018387-ci5wx26t	223	32	and	and	CC
cord-018387-ci5wx26t	223	33	resistance	resistance	NN
cord-018387-ci5wx26t	223	34	to	to	IN
cord-018387-ci5wx26t	223	35	infectious	infectious	JJ
cord-018387-ci5wx26t	223	36	and	and	CC
cord-018387-ci5wx26t	223	37	neoplastic	neoplastic	JJ
cord-018387-ci5wx26t	223	38	diseases	disease	NNS
cord-018387-ci5wx26t	223	39	.	.	.
cord-018387-ci5wx26t	224	1	The	the	DT
cord-018387-ci5wx26t	224	2	importance	importance	NN
cord-018387-ci5wx26t	224	3	of	of	IN
cord-018387-ci5wx26t	224	4	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	224	5	,	,	,
cord-018387-ci5wx26t	224	6	trace	trace	NN
cord-018387-ci5wx26t	224	7	elements	element	NNS
cord-018387-ci5wx26t	224	8	,	,	,
cord-018387-ci5wx26t	224	9	and	and	CC
cord-018387-ci5wx26t	224	10	vitamins	vitamin	NNS
cord-018387-ci5wx26t	224	11	in	in	IN
cord-018387-ci5wx26t	224	12	proper	proper	JJ
cord-018387-ci5wx26t	224	13	immune	immune	JJ
cord-018387-ci5wx26t	224	14	functioning	functioning	NN
cord-018387-ci5wx26t	224	15	is	be	VBZ
cord-018387-ci5wx26t	224	16	clear	clear	JJ
cord-018387-ci5wx26t	224	17	,	,	,
cord-018387-ci5wx26t	224	18	and	and	CC
cord-018387-ci5wx26t	224	19	deficiencies	deficiency	NNS
cord-018387-ci5wx26t	224	20	in	in	IN
cord-018387-ci5wx26t	224	21	one	one	CD
cord-018387-ci5wx26t	224	22	or	or	CC
cord-018387-ci5wx26t	224	23	more	more	JJR
cord-018387-ci5wx26t	224	24	of	of	IN
cord-018387-ci5wx26t	224	25	these	these	DT
cord-018387-ci5wx26t	224	26	nutrients	nutrient	NNS
cord-018387-ci5wx26t	224	27	may	may	MD
cord-018387-ci5wx26t	224	28	impair	impair	VB
cord-018387-ci5wx26t	224	29	practically	practically	RB
cord-018387-ci5wx26t	224	30	all	all	DT
cord-018387-ci5wx26t	224	31	forms	form	NNS
cord-018387-ci5wx26t	224	32	of	of	IN
cord-018387-ci5wx26t	224	33	immunity	immunity	NN
cord-018387-ci5wx26t	224	34	[	[	-LRB-
cord-018387-ci5wx26t	224	35	2	2	CD
cord-018387-ci5wx26t	224	36	]	]	-RRB-
cord-018387-ci5wx26t	224	37	.	.	.
cord-018387-ci5wx26t	225	1	Among	among	IN
cord-018387-ci5wx26t	225	2	them	-PRON-	PRP
cord-018387-ci5wx26t	225	3	,	,	,
cord-018387-ci5wx26t	225	4	zinc	zinc	NN
cord-018387-ci5wx26t	225	5	is	be	VBZ
cord-018387-ci5wx26t	225	6	an	an	DT
cord-018387-ci5wx26t	225	7	essential	essential	JJ
cord-018387-ci5wx26t	225	8	element	element	NN
cord-018387-ci5wx26t	225	9	of	of	IN
cord-018387-ci5wx26t	225	10	which	which	WDT
cord-018387-ci5wx26t	225	11	the	the	DT
cord-018387-ci5wx26t	225	12	significance	significance	NN
cord-018387-ci5wx26t	225	13	to	to	IN
cord-018387-ci5wx26t	225	14	health	health	NN
cord-018387-ci5wx26t	225	15	is	be	VBZ
cord-018387-ci5wx26t	225	16	indisputable	indisputable	JJ
cord-018387-ci5wx26t	225	17	,	,	,
cord-018387-ci5wx26t	225	18	as	as	IN
cord-018387-ci5wx26t	225	19	discussed	discuss	VBN
cord-018387-ci5wx26t	225	20	above	above	IN
cord-018387-ci5wx26t	225	21	[	[	-LRB-
cord-018387-ci5wx26t	225	22	119	119	CD
cord-018387-ci5wx26t	225	23	]	]	-RRB-
cord-018387-ci5wx26t	225	24	.	.	.
cord-018387-ci5wx26t	226	1	It	-PRON-	PRP
cord-018387-ci5wx26t	226	2	has	have	VBZ
cord-018387-ci5wx26t	226	3	been	be	VBN
cord-018387-ci5wx26t	226	4	shown	show	VBN
cord-018387-ci5wx26t	226	5	that	that	IN
cord-018387-ci5wx26t	226	6	zinc	zinc	NN
cord-018387-ci5wx26t	226	7	supplementation	supplementation	NN
cord-018387-ci5wx26t	226	8	enhances	enhance	VBZ
cord-018387-ci5wx26t	226	9	the	the	DT
cord-018387-ci5wx26t	226	10	innate	innate	JJ
cord-018387-ci5wx26t	226	11	immune	immune	JJ
cord-018387-ci5wx26t	226	12	responses	response	NNS
cord-018387-ci5wx26t	226	13	by	by	IN
cord-018387-ci5wx26t	226	14	increasing	increase	VBG
cord-018387-ci5wx26t	226	15	phagocytosis	phagocytosis	NN
cord-018387-ci5wx26t	226	16	and	and	CC
cord-018387-ci5wx26t	226	17	T	t	NN
cord-018387-ci5wx26t	226	18	-	-	HYPH
cord-018387-ci5wx26t	226	19	cell	cell	NN
cord-018387-ci5wx26t	226	20	functionality	functionality	NN
cord-018387-ci5wx26t	226	21	[	[	-LRB-
cord-018387-ci5wx26t	226	22	120	120	CD
cord-018387-ci5wx26t	226	23	]	]	-RRB-
cord-018387-ci5wx26t	226	24	.	.	.
cord-018387-ci5wx26t	227	1	An	an	DT
cord-018387-ci5wx26t	227	2	increase	increase	NN
cord-018387-ci5wx26t	227	3	in	in	IN
cord-018387-ci5wx26t	227	4	serum	serum	NN
cord-018387-ci5wx26t	227	5	zinc	zinc	NN
cord-018387-ci5wx26t	227	6	concentration	concentration	NN
cord-018387-ci5wx26t	227	7	was	be	VBD
cord-018387-ci5wx26t	227	8	associated	associate	VBN
cord-018387-ci5wx26t	227	9	with	with	IN
cord-018387-ci5wx26t	227	10	an	an	DT
cord-018387-ci5wx26t	227	11	increase	increase	NN
cord-018387-ci5wx26t	227	12	in	in	IN
cord-018387-ci5wx26t	227	13	the	the	DT
cord-018387-ci5wx26t	227	14	number	number	NN
cord-018387-ci5wx26t	227	15	of	of	IN
cord-018387-ci5wx26t	227	16	T	t	NN
cord-018387-ci5wx26t	227	17	cells	cell	NNS
cord-018387-ci5wx26t	227	18	[	[	-LRB-
cord-018387-ci5wx26t	227	19	119	119	CD
cord-018387-ci5wx26t	227	20	]	]	-RRB-
cord-018387-ci5wx26t	227	21	.	.	.
cord-018387-ci5wx26t	228	1	Zinc	zinc	NN
cord-018387-ci5wx26t	228	2	supplementation	supplementation	NN
cord-018387-ci5wx26t	228	3	was	be	VBD
cord-018387-ci5wx26t	228	4	also	also	RB
cord-018387-ci5wx26t	228	5	able	able	JJ
cord-018387-ci5wx26t	228	6	to	to	TO
cord-018387-ci5wx26t	228	7	improve	improve	VB
cord-018387-ci5wx26t	228	8	the	the	DT
cord-018387-ci5wx26t	228	9	generation	generation	NN
cord-018387-ci5wx26t	228	10	of	of	IN
cord-018387-ci5wx26t	228	11	NK	NK	NNP
cord-018387-ci5wx26t	228	12	cells	cell	NNS
cord-018387-ci5wx26t	228	13	from	from	IN
cord-018387-ci5wx26t	228	14	CD34	CD34	NNP
cord-018387-ci5wx26t	228	15	+	+	CC
cord-018387-ci5wx26t	228	16	cell	cell	NN
cord-018387-ci5wx26t	228	17	progenitors	progenitor	NNS
cord-018387-ci5wx26t	228	18	through	through	IN
cord-018387-ci5wx26t	228	19	the	the	DT
cord-018387-ci5wx26t	228	20	increased	increase	VBN
cord-018387-ci5wx26t	228	21	expression	expression	NN
cord-018387-ci5wx26t	228	22	of	of	IN
cord-018387-ci5wx26t	228	23	the	the	DT
cord-018387-ci5wx26t	228	24	GATA-3	GATA-3	NNP
cord-018387-ci5wx26t	228	25	transcription	transcription	NN
cord-018387-ci5wx26t	228	26	factor	factor	NN
cord-018387-ci5wx26t	228	27	[	[	-LRB-
cord-018387-ci5wx26t	228	28	7	7	CD
cord-018387-ci5wx26t	228	29	]	]	-RRB-
cord-018387-ci5wx26t	228	30	.	.	.
cord-018387-ci5wx26t	229	1	Vitamin	vitamin	NN
cord-018387-ci5wx26t	229	2	C	C	NNP
cord-018387-ci5wx26t	229	3	has	have	VBZ
cord-018387-ci5wx26t	229	4	also	also	RB
cord-018387-ci5wx26t	229	5	been	be	VBN
cord-018387-ci5wx26t	229	6	found	find	VBN
cord-018387-ci5wx26t	229	7	to	to	TO
cord-018387-ci5wx26t	229	8	positively	positively	RB
cord-018387-ci5wx26t	229	9	modulate	modulate	VB
cord-018387-ci5wx26t	229	10	immunosenescence	immunosenescence	RB
cord-018387-ci5wx26t	229	11	and	and	CC
cord-018387-ci5wx26t	229	12	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	229	13	,	,	,
cord-018387-ci5wx26t	229	14	representing	represent	VBG
cord-018387-ci5wx26t	229	15	two	two	CD
cord-018387-ci5wx26t	229	16	main	main	JJ
cord-018387-ci5wx26t	229	17	hallmarks	hallmark	NNS
cord-018387-ci5wx26t	229	18	of	of	IN
cord-018387-ci5wx26t	229	19	human	human	JJ
cord-018387-ci5wx26t	229	20	aging	aging	NN
cord-018387-ci5wx26t	229	21	.	.	.
cord-018387-ci5wx26t	230	1	Moreover	moreover	RB
cord-018387-ci5wx26t	230	2	,	,	,
cord-018387-ci5wx26t	230	3	it	-PRON-	PRP
cord-018387-ci5wx26t	230	4	has	have	VBZ
cord-018387-ci5wx26t	230	5	been	be	VBN
cord-018387-ci5wx26t	230	6	shown	show	VBN
cord-018387-ci5wx26t	230	7	to	to	TO
cord-018387-ci5wx26t	230	8	epigenetically	epigenetically	RB
cord-018387-ci5wx26t	230	9	regulate	regulate	VB
cord-018387-ci5wx26t	230	10	genome	genome	NN
cord-018387-ci5wx26t	230	11	integrity	integrity	NN
cord-018387-ci5wx26t	230	12	and	and	CC
cord-018387-ci5wx26t	230	13	stability	stability	NN
cord-018387-ci5wx26t	230	14	,	,	,
cord-018387-ci5wx26t	230	15	indicating	indicate	VBG
cord-018387-ci5wx26t	230	16	a	a	DT
cord-018387-ci5wx26t	230	17	key	key	JJ
cord-018387-ci5wx26t	230	18	role	role	NN
cord-018387-ci5wx26t	230	19	of	of	IN
cord-018387-ci5wx26t	230	20	vitamin	vitamin	NN
cord-018387-ci5wx26t	230	21	C	c	NN
cord-018387-ci5wx26t	230	22	in	in	IN
cord-018387-ci5wx26t	230	23	healthy	healthy	JJ
cord-018387-ci5wx26t	230	24	aging	age	VBG
cord-018387-ci5wx26t	230	25	[	[	-LRB-
cord-018387-ci5wx26t	230	26	121	121	CD
cord-018387-ci5wx26t	230	27	]	]	-RRB-
cord-018387-ci5wx26t	230	28	.	.	.
cord-018387-ci5wx26t	231	1	Vitamin	vitamin	NN
cord-018387-ci5wx26t	231	2	E	e	NN
cord-018387-ci5wx26t	231	3	supplementation	supplementation	NN
cord-018387-ci5wx26t	231	4	has	have	VBZ
cord-018387-ci5wx26t	231	5	been	be	VBN
cord-018387-ci5wx26t	231	6	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	231	7	to	to	TO
cord-018387-ci5wx26t	231	8	improve	improve	VB
cord-018387-ci5wx26t	231	9	immune	immune	JJ
cord-018387-ci5wx26t	231	10	responsiveness	responsiveness	NN
cord-018387-ci5wx26t	231	11	in	in	IN
cord-018387-ci5wx26t	231	12	healthy	healthy	JJ
cord-018387-ci5wx26t	231	13	elderly	elderly	JJ
cord-018387-ci5wx26t	231	14	individuals	individual	NNS
cord-018387-ci5wx26t	231	15	by	by	IN
cord-018387-ci5wx26t	231	16	the	the	DT
cord-018387-ci5wx26t	231	17	enhancement	enhancement	NN
cord-018387-ci5wx26t	231	18	of	of	IN
cord-018387-ci5wx26t	231	19	cell	cell	NN
cord-018387-ci5wx26t	231	20	-	-	HYPH
cord-018387-ci5wx26t	231	21	mediated	mediate	VBN
cord-018387-ci5wx26t	231	22	immunity	immunity	NN
cord-018387-ci5wx26t	231	23	[	[	-LRB-
cord-018387-ci5wx26t	231	24	122	122	CD
cord-018387-ci5wx26t	231	25	]	]	-RRB-
cord-018387-ci5wx26t	231	26	.	.	.
cord-018387-ci5wx26t	232	1	It	-PRON-	PRP
cord-018387-ci5wx26t	232	2	was	be	VBD
cord-018387-ci5wx26t	232	3	also	also	RB
cord-018387-ci5wx26t	232	4	able	able	JJ
cord-018387-ci5wx26t	232	5	to	to	TO
cord-018387-ci5wx26t	232	6	reverse	reverse	VB
cord-018387-ci5wx26t	232	7	many	many	JJ
cord-018387-ci5wx26t	232	8	of	of	IN
cord-018387-ci5wx26t	232	9	the	the	DT
cord-018387-ci5wx26t	232	10	T	t	NN
cord-018387-ci5wx26t	232	11	-	-	HYPH
cord-018387-ci5wx26t	232	12	cell	cell	NN
cord-018387-ci5wx26t	232	13	age	age	NN
cord-018387-ci5wx26t	232	14	-	-	HYPH
cord-018387-ci5wx26t	232	15	associated	associate	VBN
cord-018387-ci5wx26t	232	16	defects	defect	NNS
cord-018387-ci5wx26t	232	17	,	,	,
cord-018387-ci5wx26t	232	18	including	include	VBG
cord-018387-ci5wx26t	232	19	reduced	reduce	VBN
cord-018387-ci5wx26t	232	20	levels	level	NNS
cord-018387-ci5wx26t	232	21	of	of	IN
cord-018387-ci5wx26t	232	22	phosphorylation	phosphorylation	NN
cord-018387-ci5wx26t	232	23	of	of	IN
cord-018387-ci5wx26t	232	24	critical	critical	JJ
cord-018387-ci5wx26t	232	25	signaling	signal	VBG
cord-018387-ci5wx26t	232	26	proteins	protein	NNS
cord-018387-ci5wx26t	232	27	,	,	,
cord-018387-ci5wx26t	232	28	as	as	RB
cord-018387-ci5wx26t	232	29	well	well	RB
cord-018387-ci5wx26t	232	30	as	as	IN
cord-018387-ci5wx26t	232	31	to	to	TO
cord-018387-ci5wx26t	232	32	improve	improve	VB
cord-018387-ci5wx26t	232	33	defective	defective	JJ
cord-018387-ci5wx26t	232	34	immune	immune	JJ
cord-018387-ci5wx26t	232	35	synapse	synapse	NN
cord-018387-ci5wx26t	232	36	formation	formation	NN
cord-018387-ci5wx26t	232	37	.	.	.
cord-018387-ci5wx26t	233	1	Vitamin	vitamin	NN
cord-018387-ci5wx26t	233	2	E	e	NN
cord-018387-ci5wx26t	233	3	also	also	RB
cord-018387-ci5wx26t	233	4	enhances	enhance	VBZ
cord-018387-ci5wx26t	233	5	the	the	DT
cord-018387-ci5wx26t	233	6	production	production	NN
cord-018387-ci5wx26t	233	7	of	of	IN
cord-018387-ci5wx26t	233	8	IL-2	IL-2	NNP
cord-018387-ci5wx26t	233	9	,	,	,
cord-018387-ci5wx26t	233	10	the	the	DT
cord-018387-ci5wx26t	233	11	expression	expression	NN
cord-018387-ci5wx26t	233	12	of	of	IN
cord-018387-ci5wx26t	233	13	several	several	JJ
cord-018387-ci5wx26t	233	14	cell	cell	NN
cord-018387-ci5wx26t	233	15	cycle	cycle	NN
cord-018387-ci5wx26t	233	16	control	control	NN
cord-018387-ci5wx26t	233	17	proteins	protein	NNS
cord-018387-ci5wx26t	233	18	,	,	,
cord-018387-ci5wx26t	233	19	and	and	CC
cord-018387-ci5wx26t	233	20	T	t	NN
cord-018387-ci5wx26t	233	21	-	-	HYPH
cord-018387-ci5wx26t	233	22	cell	cell	NN
cord-018387-ci5wx26t	233	23	proliferation	proliferation	NN
cord-018387-ci5wx26t	233	24	[	[	-LRB-
cord-018387-ci5wx26t	233	25	123	123	CD
cord-018387-ci5wx26t	233	26	]	]	-RRB-
cord-018387-ci5wx26t	233	27	.	.	.
cord-018387-ci5wx26t	234	1	Intake	intake	NN
cord-018387-ci5wx26t	234	2	of	of	IN
cord-018387-ci5wx26t	234	3	vitamin	vitamin	NN
cord-018387-ci5wx26t	234	4	E	e	NN
cord-018387-ci5wx26t	234	5	above	above	IN
cord-018387-ci5wx26t	234	6	recommended	recommend	VBN
cord-018387-ci5wx26t	234	7	levels	level	NNS
cord-018387-ci5wx26t	234	8	has	have	VBZ
cord-018387-ci5wx26t	234	9	been	be	VBN
cord-018387-ci5wx26t	234	10	shown	show	VBN
cord-018387-ci5wx26t	234	11	to	to	TO
cord-018387-ci5wx26t	234	12	enhance	enhance	VB
cord-018387-ci5wx26t	234	13	T	t	NN
cord-018387-ci5wx26t	234	14	-	-	HYPH
cord-018387-ci5wx26t	234	15	cell	cell	NN
cord-018387-ci5wx26t	234	16	function	function	NN
cord-018387-ci5wx26t	234	17	in	in	IN
cord-018387-ci5wx26t	234	18	aged	aged	JJ
cord-018387-ci5wx26t	234	19	animals	animal	NNS
cord-018387-ci5wx26t	234	20	and	and	CC
cord-018387-ci5wx26t	234	21	humans	human	NNS
cord-018387-ci5wx26t	234	22	.	.	.
cord-018387-ci5wx26t	235	1	This	this	DT
cord-018387-ci5wx26t	235	2	effect	effect	NN
cord-018387-ci5wx26t	235	3	is	be	VBZ
cord-018387-ci5wx26t	235	4	believed	believe	VBN
cord-018387-ci5wx26t	235	5	to	to	TO
cord-018387-ci5wx26t	235	6	contribute	contribute	VB
cord-018387-ci5wx26t	235	7	to	to	IN
cord-018387-ci5wx26t	235	8	an	an	DT
cord-018387-ci5wx26t	235	9	improved	improved	JJ
cord-018387-ci5wx26t	235	10	resistance	resistance	NN
cord-018387-ci5wx26t	235	11	to	to	IN
cord-018387-ci5wx26t	235	12	influenza	influenza	NN
cord-018387-ci5wx26t	235	13	infection	infection	NN
cord-018387-ci5wx26t	235	14	and	and	CC
cord-018387-ci5wx26t	235	15	to	to	IN
cord-018387-ci5wx26t	235	16	a	a	DT
cord-018387-ci5wx26t	235	17	reduced	reduce	VBN
cord-018387-ci5wx26t	235	18	incidence	incidence	NN
cord-018387-ci5wx26t	235	19	of	of	IN
cord-018387-ci5wx26t	235	20	upper	upper	JJ
cord-018387-ci5wx26t	235	21	respiratory	respiratory	JJ
cord-018387-ci5wx26t	235	22	infections	infection	NNS
cord-018387-ci5wx26t	235	23	in	in	IN
cord-018387-ci5wx26t	235	24	elderly	elderly	JJ
cord-018387-ci5wx26t	235	25	people	people	NNS
cord-018387-ci5wx26t	235	26	[	[	-LRB-
cord-018387-ci5wx26t	235	27	1	1	CD
cord-018387-ci5wx26t	235	28	,	,	,
cord-018387-ci5wx26t	235	29	124	124	CD
cord-018387-ci5wx26t	235	30	]	]	-RRB-
cord-018387-ci5wx26t	235	31	.	.	.
cord-018387-ci5wx26t	236	1	Here	here	RB
cord-018387-ci5wx26t	236	2	,	,	,
cord-018387-ci5wx26t	236	3	we	-PRON-	PRP
cord-018387-ci5wx26t	236	4	can	can	MD
cord-018387-ci5wx26t	236	5	provide	provide	VB
cord-018387-ci5wx26t	236	6	only	only	RB
cord-018387-ci5wx26t	236	7	a	a	DT
cord-018387-ci5wx26t	236	8	few	few	JJ
cord-018387-ci5wx26t	236	9	examples	example	NNS
cord-018387-ci5wx26t	236	10	,	,	,
cord-018387-ci5wx26t	236	11	limited	limit	VBN
cord-018387-ci5wx26t	236	12	to	to	IN
cord-018387-ci5wx26t	236	13	spices	spice	NNS
cord-018387-ci5wx26t	236	14	and	and	CC
cord-018387-ci5wx26t	236	15	fruits	fruit	NNS
cord-018387-ci5wx26t	236	16	and	and	CC
cord-018387-ci5wx26t	236	17	their	-PRON-	PRP$
cord-018387-ci5wx26t	236	18	bioactive	bioactive	JJ
cord-018387-ci5wx26t	236	19	components	component	NNS
cord-018387-ci5wx26t	236	20	,	,	,
cord-018387-ci5wx26t	236	21	known	know	VBN
cord-018387-ci5wx26t	236	22	to	to	TO
cord-018387-ci5wx26t	236	23	modulate	modulate	VB
cord-018387-ci5wx26t	236	24	different	different	JJ
cord-018387-ci5wx26t	236	25	stages	stage	NNS
cord-018387-ci5wx26t	236	26	of	of	IN
cord-018387-ci5wx26t	236	27	tumorigenesis	tumorigenesis	NN
cord-018387-ci5wx26t	236	28	,	,	,
cord-018387-ci5wx26t	236	29	including	include	VBG
cord-018387-ci5wx26t	236	30	tumor	tumor	NN
cord-018387-ci5wx26t	236	31	cell	cell	NN
cord-018387-ci5wx26t	236	32	survival	survival	NN
cord-018387-ci5wx26t	236	33	,	,	,
cord-018387-ci5wx26t	236	34	proliferation	proliferation	NN
cord-018387-ci5wx26t	236	35	,	,	,
cord-018387-ci5wx26t	236	36	invasion	invasion	NN
cord-018387-ci5wx26t	236	37	,	,	,
cord-018387-ci5wx26t	236	38	and	and	CC
cord-018387-ci5wx26t	236	39	angiogenesis	angiogenesis	NN
cord-018387-ci5wx26t	236	40	.	.	.
cord-018387-ci5wx26t	237	1	The	the	DT
cord-018387-ci5wx26t	237	2	anticancer	anticancer	JJ
cord-018387-ci5wx26t	237	3	activities	activity	NNS
cord-018387-ci5wx26t	237	4	of	of	IN
cord-018387-ci5wx26t	237	5	spices	spice	NNS
cord-018387-ci5wx26t	237	6	are	be	VBP
cord-018387-ci5wx26t	237	7	mediated	mediate	VBN
cord-018387-ci5wx26t	237	8	primarily	primarily	RB
cord-018387-ci5wx26t	237	9	through	through	IN
cord-018387-ci5wx26t	237	10	the	the	DT
cord-018387-ci5wx26t	237	11	suppression	suppression	NN
cord-018387-ci5wx26t	237	12	of	of	IN
cord-018387-ci5wx26t	237	13	inflammation	inflammation	NN
cord-018387-ci5wx26t	237	14	.	.	.
cord-018387-ci5wx26t	238	1	Bioactive	bioactive	JJ
cord-018387-ci5wx26t	238	2	components	component	NNS
cord-018387-ci5wx26t	238	3	of	of	IN
cord-018387-ci5wx26t	238	4	spices	spice	NNS
cord-018387-ci5wx26t	238	5	,	,	,
cord-018387-ci5wx26t	238	6	such	such	JJ
cord-018387-ci5wx26t	238	7	as	as	IN
cord-018387-ci5wx26t	238	8	eugenol	eugenol	NN
cord-018387-ci5wx26t	238	9	and	and	CC
cord-018387-ci5wx26t	238	10	6-gingerol	6-gingerol	CD
cord-018387-ci5wx26t	238	11	,	,	,
cord-018387-ci5wx26t	238	12	prevent	prevent	VB
cord-018387-ci5wx26t	238	13	the	the	DT
cord-018387-ci5wx26t	238	14	release	release	NN
cord-018387-ci5wx26t	238	15	of	of	IN
cord-018387-ci5wx26t	238	16	TNF	TNF	NNP
cord-018387-ci5wx26t	238	17	and	and	CC
cord-018387-ci5wx26t	238	18	IL-1β	IL-1β	NNP
cord-018387-ci5wx26t	238	19	[	[	-LRB-
cord-018387-ci5wx26t	238	20	125	125	CD
cord-018387-ci5wx26t	238	21	]	]	-RRB-
cord-018387-ci5wx26t	239	1	in	in	IN
cord-018387-ci5wx26t	239	2	vitro	vitro	FW
cord-018387-ci5wx26t	239	3	stimulated	stimulate	VBN
cord-018387-ci5wx26t	239	4	macrophages	macrophage	NNS
cord-018387-ci5wx26t	239	5	[	[	-LRB-
cord-018387-ci5wx26t	239	6	126	126	CD
cord-018387-ci5wx26t	239	7	]	]	-RRB-
cord-018387-ci5wx26t	239	8	.	.	.
cord-018387-ci5wx26t	240	1	Curcumin	curcumin	NN
cord-018387-ci5wx26t	240	2	has	have	VBZ
cord-018387-ci5wx26t	240	3	been	be	VBN
cord-018387-ci5wx26t	240	4	shown	show	VBN
cord-018387-ci5wx26t	240	5	to	to	TO
cord-018387-ci5wx26t	240	6	suppress	suppress	VB
cord-018387-ci5wx26t	240	7	the	the	DT
cord-018387-ci5wx26t	240	8	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	240	9	mediators	mediator	NNS
cord-018387-ci5wx26t	240	10	NF	nf	NN
cord-018387-ci5wx26t	240	11	-	-	HYPH
cord-018387-ci5wx26t	240	12	κβ	κβ	NNP
cord-018387-ci5wx26t	240	13	and	and	CC
cord-018387-ci5wx26t	240	14	COX-2	COX-2	NNP
cord-018387-ci5wx26t	240	15	[	[	-LRB-
cord-018387-ci5wx26t	240	16	127	127	CD
cord-018387-ci5wx26t	240	17	]	]	-RRB-
cord-018387-ci5wx26t	240	18	,	,	,
cord-018387-ci5wx26t	240	19	anethole	anethole	NNP
cord-018387-ci5wx26t	240	20	inhibits	inhibit	VBZ
cord-018387-ci5wx26t	240	21	NF	NF	NNP
cord-018387-ci5wx26t	240	22	-	-	HYPH
cord-018387-ci5wx26t	240	23	κβ	κβ	NN
cord-018387-ci5wx26t	240	24	activation	activation	NN
cord-018387-ci5wx26t	240	25	and	and	CC
cord-018387-ci5wx26t	240	26	cytokine	cytokine	NN
cord-018387-ci5wx26t	240	27	production	production	NN
cord-018387-ci5wx26t	240	28	[	[	-LRB-
cord-018387-ci5wx26t	240	29	128	128	CD
cord-018387-ci5wx26t	240	30	]	]	-RRB-
cord-018387-ci5wx26t	240	31	,	,	,
cord-018387-ci5wx26t	240	32	and	and	CC
cord-018387-ci5wx26t	240	33	cinnamaldehyde	cinnamaldehyde	NNP
cord-018387-ci5wx26t	240	34	blocks	block	VBZ
cord-018387-ci5wx26t	240	35	the	the	DT
cord-018387-ci5wx26t	240	36	age	age	NN
cord-018387-ci5wx26t	240	37	-	-	HYPH
cord-018387-ci5wx26t	240	38	related	relate	VBN
cord-018387-ci5wx26t	240	39	activation	activation	NN
cord-018387-ci5wx26t	240	40	of	of	IN
cord-018387-ci5wx26t	240	41	NF	nf	NN
cord-018387-ci5wx26t	240	42	-	-	HYPH
cord-018387-ci5wx26t	240	43	κβ	κβ	NN
cord-018387-ci5wx26t	240	44	and	and	CC
cord-018387-ci5wx26t	240	45	targets	target	VBZ
cord-018387-ci5wx26t	240	46	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	240	47	COX-2	COX-2	NNP
cord-018387-ci5wx26t	240	48	as	as	RB
cord-018387-ci5wx26t	240	49	well	well	RB
cord-018387-ci5wx26t	240	50	as	as	IN
cord-018387-ci5wx26t	240	51	induces	induce	VBZ
cord-018387-ci5wx26t	240	52	nitric	nitric	JJ
cord-018387-ci5wx26t	240	53	oxide	oxide	NN
cord-018387-ci5wx26t	240	54	synthase	synthase	NN
cord-018387-ci5wx26t	240	55	(	(	-LRB-
cord-018387-ci5wx26t	240	56	NOS	NOS	NNP
cord-018387-ci5wx26t	240	57	)	)	-RRB-
cord-018387-ci5wx26t	240	58	[	[	-LRB-
cord-018387-ci5wx26t	240	59	129	129	CD
cord-018387-ci5wx26t	240	60	]	]	-RRB-
cord-018387-ci5wx26t	240	61	.	.	.
cord-018387-ci5wx26t	241	1	Ursolic	Ursolic	NNP
cord-018387-ci5wx26t	241	2	acid	acid	NN
cord-018387-ci5wx26t	241	3	,	,	,
cord-018387-ci5wx26t	241	4	which	which	WDT
cord-018387-ci5wx26t	241	5	is	be	VBZ
cord-018387-ci5wx26t	241	6	present	present	JJ
cord-018387-ci5wx26t	241	7	in	in	IN
cord-018387-ci5wx26t	241	8	many	many	JJ
cord-018387-ci5wx26t	241	9	fruits	fruit	NNS
cord-018387-ci5wx26t	241	10	,	,	,
cord-018387-ci5wx26t	241	11	including	include	VBG
cord-018387-ci5wx26t	241	12	apples	apple	NNS
cord-018387-ci5wx26t	241	13	,	,	,
cord-018387-ci5wx26t	241	14	pears	pear	NNS
cord-018387-ci5wx26t	241	15	,	,	,
cord-018387-ci5wx26t	241	16	plums	plum	NNS
cord-018387-ci5wx26t	241	17	,	,	,
cord-018387-ci5wx26t	241	18	bearberries	bearberry	NNS
cord-018387-ci5wx26t	241	19	,	,	,
cord-018387-ci5wx26t	241	20	loquat	loquat	NN
cord-018387-ci5wx26t	241	21	,	,	,
cord-018387-ci5wx26t	241	22	jamun	jamun	NN
cord-018387-ci5wx26t	241	23	,	,	,
cord-018387-ci5wx26t	241	24	and	and	CC
cord-018387-ci5wx26t	241	25	rosemary	rosemary	NN
cord-018387-ci5wx26t	241	26	,	,	,
cord-018387-ci5wx26t	241	27	has	have	VBZ
cord-018387-ci5wx26t	241	28	been	be	VBN
cord-018387-ci5wx26t	241	29	found	find	VBN
cord-018387-ci5wx26t	241	30	to	to	TO
cord-018387-ci5wx26t	241	31	exert	exert	VB
cord-018387-ci5wx26t	241	32	antitumor	antitumor	JJ
cord-018387-ci5wx26t	241	33	activity	activity	NN
cord-018387-ci5wx26t	241	34	against	against	IN
cord-018387-ci5wx26t	241	35	colon	colon	NN
cord-018387-ci5wx26t	241	36	cancer	cancer	NN
cord-018387-ci5wx26t	241	37	[	[	-LRB-
cord-018387-ci5wx26t	241	38	130	130	CD
cord-018387-ci5wx26t	241	39	]	]	-RRB-
cord-018387-ci5wx26t	241	40	,	,	,
cord-018387-ci5wx26t	241	41	breast	breast	NN
cord-018387-ci5wx26t	241	42	cancer	cancer	NN
cord-018387-ci5wx26t	241	43	[	[	-LRB-
cord-018387-ci5wx26t	241	44	131	131	CD
cord-018387-ci5wx26t	241	45	]	]	-RRB-
cord-018387-ci5wx26t	241	46	,	,	,
cord-018387-ci5wx26t	241	47	nonsmall	nonsmall	NNP
cord-018387-ci5wx26t	241	48	cell	cell	NN
cord-018387-ci5wx26t	241	49	lung	lung	NN
cord-018387-ci5wx26t	241	50	cancer	cancer	NN
cord-018387-ci5wx26t	241	51	[	[	-LRB-
cord-018387-ci5wx26t	241	52	132	132	CD
cord-018387-ci5wx26t	241	53	]	]	-RRB-
cord-018387-ci5wx26t	241	54	,	,	,
cord-018387-ci5wx26t	241	55	pancreatic	pancreatic	JJ
cord-018387-ci5wx26t	241	56	cancer	cancer	NN
cord-018387-ci5wx26t	241	57	[	[	-LRB-
cord-018387-ci5wx26t	241	58	105	105	CD
cord-018387-ci5wx26t	241	59	]	]	-RRB-
cord-018387-ci5wx26t	241	60	,	,	,
cord-018387-ci5wx26t	241	61	melanoma	melanoma	NN
cord-018387-ci5wx26t	241	62	[	[	-LRB-
cord-018387-ci5wx26t	241	63	133	133	CD
cord-018387-ci5wx26t	241	64	]	]	-RRB-
cord-018387-ci5wx26t	241	65	,	,	,
cord-018387-ci5wx26t	241	66	multiple	multiple	JJ
cord-018387-ci5wx26t	241	67	myeloma	myeloma	NN
cord-018387-ci5wx26t	241	68	[	[	-LRB-
cord-018387-ci5wx26t	241	69	134	134	CD
cord-018387-ci5wx26t	241	70	]	]	-RRB-
cord-018387-ci5wx26t	241	71	,	,	,
cord-018387-ci5wx26t	241	72	cervical	cervical	JJ
cord-018387-ci5wx26t	241	73	cancer	cancer	NN
cord-018387-ci5wx26t	241	74	[	[	-LRB-
cord-018387-ci5wx26t	241	75	135	135	CD
cord-018387-ci5wx26t	241	76	]	]	-RRB-
cord-018387-ci5wx26t	241	77	,	,	,
cord-018387-ci5wx26t	241	78	and	and	CC
cord-018387-ci5wx26t	241	79	prostate	prostate	NN
cord-018387-ci5wx26t	241	80	cancer	cancer	NN
cord-018387-ci5wx26t	241	81	[	[	-LRB-
cord-018387-ci5wx26t	241	82	108	108	CD
cord-018387-ci5wx26t	241	83	]	]	-RRB-
cord-018387-ci5wx26t	241	84	.	.	.
cord-018387-ci5wx26t	242	1	Also	also	RB
cord-018387-ci5wx26t	242	2	,	,	,
cord-018387-ci5wx26t	242	3	several	several	JJ
cord-018387-ci5wx26t	242	4	other	other	JJ
cord-018387-ci5wx26t	242	5	nutraceuticals	nutraceutical	NNS
cord-018387-ci5wx26t	242	6	have	have	VBP
cord-018387-ci5wx26t	242	7	been	be	VBN
cord-018387-ci5wx26t	242	8	shown	show	VBN
cord-018387-ci5wx26t	242	9	to	to	TO
cord-018387-ci5wx26t	242	10	exert	exert	VB
cord-018387-ci5wx26t	242	11	antitumor	antitumor	JJ
cord-018387-ci5wx26t	242	12	and	and	CC
cord-018387-ci5wx26t	242	13	anti	anti	JJ
cord-018387-ci5wx26t	242	14	-	-	JJ
cord-018387-ci5wx26t	242	15	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	242	16	activities	activity	NNS
cord-018387-ci5wx26t	242	17	.	.	.
cord-018387-ci5wx26t	243	1	Since	since	IN
cord-018387-ci5wx26t	243	2	oxidative	oxidative	JJ
cord-018387-ci5wx26t	243	3	stress	stress	NN
cord-018387-ci5wx26t	243	4	and	and	CC
cord-018387-ci5wx26t	243	5	inflammation	inflammation	NN
cord-018387-ci5wx26t	243	6	are	be	VBP
cord-018387-ci5wx26t	243	7	two	two	CD
cord-018387-ci5wx26t	243	8	of	of	IN
cord-018387-ci5wx26t	243	9	the	the	DT
cord-018387-ci5wx26t	243	10	major	major	JJ
cord-018387-ci5wx26t	243	11	triggers	trigger	NNS
cord-018387-ci5wx26t	243	12	of	of	IN
cord-018387-ci5wx26t	243	13	age	age	NN
cord-018387-ci5wx26t	243	14	-	-	HYPH
cord-018387-ci5wx26t	243	15	related	relate	VBN
cord-018387-ci5wx26t	243	16	pathologies	pathology	NNS
cord-018387-ci5wx26t	243	17	and	and	CC
cord-018387-ci5wx26t	243	18	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	243	19	,	,	,
cord-018387-ci5wx26t	243	20	the	the	DT
cord-018387-ci5wx26t	243	21	consumption	consumption	NN
cord-018387-ci5wx26t	243	22	of	of	IN
cord-018387-ci5wx26t	243	23	phytochemicals	phytochemical	NNS
cord-018387-ci5wx26t	243	24	from	from	IN
cord-018387-ci5wx26t	243	25	fruits	fruit	NNS
cord-018387-ci5wx26t	243	26	,	,	,
cord-018387-ci5wx26t	243	27	vegetables	vegetable	NNS
cord-018387-ci5wx26t	243	28	,	,	,
cord-018387-ci5wx26t	243	29	herbs	herb	NNS
cord-018387-ci5wx26t	243	30	,	,	,
cord-018387-ci5wx26t	243	31	and	and	CC
cord-018387-ci5wx26t	243	32	spices	spice	NNS
cord-018387-ci5wx26t	243	33	may	may	MD
cord-018387-ci5wx26t	243	34	exert	exert	VB
cord-018387-ci5wx26t	243	35	relevant	relevant	JJ
cord-018387-ci5wx26t	243	36	immunomodulatory	immunomodulatory	NN
cord-018387-ci5wx26t	243	37	and	and	CC
cord-018387-ci5wx26t	243	38	anti	anti	JJ
cord-018387-ci5wx26t	243	39	-	-	JJ
cord-018387-ci5wx26t	243	40	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	243	41	activities	activity	NNS
cord-018387-ci5wx26t	243	42	also	also	RB
cord-018387-ci5wx26t	243	43	in	in	IN
cord-018387-ci5wx26t	243	44	the	the	DT
cord-018387-ci5wx26t	243	45	context	context	NN
cord-018387-ci5wx26t	243	46	of	of	IN
cord-018387-ci5wx26t	243	47	the	the	DT
cord-018387-ci5wx26t	243	48	aging	age	VBG
cord-018387-ci5wx26t	243	49	brain	brain	NN
cord-018387-ci5wx26t	243	50	[	[	-LRB-
cord-018387-ci5wx26t	243	51	86	86	CD
cord-018387-ci5wx26t	243	52	]	]	-RRB-
cord-018387-ci5wx26t	243	53	.	.	.
cord-018387-ci5wx26t	244	1	Compelling	compelling	JJ
cord-018387-ci5wx26t	244	2	evidence	evidence	NN
cord-018387-ci5wx26t	244	3	has	have	VBZ
cord-018387-ci5wx26t	244	4	shown	show	VBN
cord-018387-ci5wx26t	244	5	that	that	IN
cord-018387-ci5wx26t	244	6	dietary	dietary	JJ
cord-018387-ci5wx26t	244	7	phytochemicals	phytochemical	NNS
cord-018387-ci5wx26t	244	8	,	,	,
cord-018387-ci5wx26t	244	9	particularly	particularly	RB
cord-018387-ci5wx26t	244	10	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	244	11	,	,	,
cord-018387-ci5wx26t	244	12	have	have	VBP
cord-018387-ci5wx26t	244	13	properties	property	NNS
cord-018387-ci5wx26t	244	14	that	that	WDT
cord-018387-ci5wx26t	244	15	may	may	MD
cord-018387-ci5wx26t	244	16	suppress	suppress	VB
cord-018387-ci5wx26t	244	17	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	244	18	and	and	CC
cord-018387-ci5wx26t	244	19	prevent	prevent	VB
cord-018387-ci5wx26t	244	20	toxic	toxic	JJ
cord-018387-ci5wx26t	244	21	and	and	CC
cord-018387-ci5wx26t	244	22	degenerative	degenerative	JJ
cord-018387-ci5wx26t	244	23	effects	effect	NNS
cord-018387-ci5wx26t	244	24	in	in	IN
cord-018387-ci5wx26t	244	25	the	the	DT
cord-018387-ci5wx26t	244	26	brain	brain	NN
cord-018387-ci5wx26t	244	27	.	.	.
cord-018387-ci5wx26t	245	1	The	the	DT
cord-018387-ci5wx26t	245	2	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	245	3	by	by	IN
cord-018387-ci5wx26t	245	4	which	which	WDT
cord-018387-ci5wx26t	245	5	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	245	6	exert	exert	VBP
cord-018387-ci5wx26t	245	7	their	-PRON-	PRP$
cord-018387-ci5wx26t	245	8	action	action	NN
cord-018387-ci5wx26t	245	9	are	be	VBP
cord-018387-ci5wx26t	245	10	not	not	RB
cord-018387-ci5wx26t	245	11	fully	fully	RB
cord-018387-ci5wx26t	245	12	understood	understand	VBN
cord-018387-ci5wx26t	245	13	,	,	,
cord-018387-ci5wx26t	245	14	but	but	CC
cord-018387-ci5wx26t	245	15	it	-PRON-	PRP
cord-018387-ci5wx26t	245	16	is	be	VBZ
cord-018387-ci5wx26t	245	17	clear	clear	JJ
cord-018387-ci5wx26t	245	18	that	that	IN
cord-018387-ci5wx26t	245	19	they	-PRON-	PRP
cord-018387-ci5wx26t	245	20	have	have	VBP
cord-018387-ci5wx26t	245	21	a	a	DT
cord-018387-ci5wx26t	245	22	direct	direct	JJ
cord-018387-ci5wx26t	245	23	effect	effect	NN
cord-018387-ci5wx26t	245	24	through	through	IN
cord-018387-ci5wx26t	245	25	their	-PRON-	PRP$
cord-018387-ci5wx26t	245	26	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	245	27	activities	activity	NNS
cord-018387-ci5wx26t	245	28	.	.	.
cord-018387-ci5wx26t	246	1	They	-PRON-	PRP
cord-018387-ci5wx26t	246	2	have	have	VBP
cord-018387-ci5wx26t	246	3	also	also	RB
cord-018387-ci5wx26t	246	4	been	be	VBN
cord-018387-ci5wx26t	246	5	shown	show	VBN
cord-018387-ci5wx26t	246	6	to	to	TO
cord-018387-ci5wx26t	246	7	modulate	modulate	VB
cord-018387-ci5wx26t	246	8	intracellular	intracellular	JJ
cord-018387-ci5wx26t	246	9	signaling	signal	VBG
cord-018387-ci5wx26t	246	10	cascades	cascade	NNS
cord-018387-ci5wx26t	246	11	,	,	,
cord-018387-ci5wx26t	246	12	including	include	VBG
cord-018387-ci5wx26t	246	13	the	the	DT
cord-018387-ci5wx26t	246	14	PI3K	PI3K	NNP
cord-018387-ci5wx26t	246	15	-	-	HYPH
cord-018387-ci5wx26t	246	16	Akt	Akt	NNP
cord-018387-ci5wx26t	246	17	,	,	,
cord-018387-ci5wx26t	246	18	MAPK	MAPK	NNP
cord-018387-ci5wx26t	246	19	,	,	,
cord-018387-ci5wx26t	246	20	Nrf2	Nrf2	NNP
cord-018387-ci5wx26t	246	21	,	,	,
cord-018387-ci5wx26t	246	22	and	and	CC
cord-018387-ci5wx26t	246	23	MEK	MEK	NNP
cord-018387-ci5wx26t	246	24	pathways	pathway	NNS
cord-018387-ci5wx26t	246	25	.	.	.
cord-018387-ci5wx26t	247	1	Polyphenols	Polyphenols	NNP
cord-018387-ci5wx26t	247	2	also	also	RB
cord-018387-ci5wx26t	247	3	interact	interact	VBP
cord-018387-ci5wx26t	247	4	with	with	IN
cord-018387-ci5wx26t	247	5	a	a	DT
cord-018387-ci5wx26t	247	6	range	range	NN
cord-018387-ci5wx26t	247	7	of	of	IN
cord-018387-ci5wx26t	247	8	neurotransmitters	neurotransmitter	NNS
cord-018387-ci5wx26t	247	9	,	,	,
cord-018387-ci5wx26t	247	10	illustrating	illustrate	VBG
cord-018387-ci5wx26t	247	11	that	that	IN
cord-018387-ci5wx26t	247	12	these	these	DT
cord-018387-ci5wx26t	247	13	compounds	compound	NNS
cord-018387-ci5wx26t	247	14	can	can	MD
cord-018387-ci5wx26t	247	15	promote	promote	VB
cord-018387-ci5wx26t	247	16	their	-PRON-	PRP$
cord-018387-ci5wx26t	247	17	health	health	NN
cord-018387-ci5wx26t	247	18	benefits	benefit	NNS
cord-018387-ci5wx26t	247	19	in	in	IN
cord-018387-ci5wx26t	247	20	the	the	DT
cord-018387-ci5wx26t	247	21	brain	brain	NN
cord-018387-ci5wx26t	247	22	through	through	IN
cord-018387-ci5wx26t	247	23	a	a	DT
cord-018387-ci5wx26t	247	24	direct	direct	JJ
cord-018387-ci5wx26t	247	25	,	,	,
cord-018387-ci5wx26t	247	26	indirect	indirect	JJ
cord-018387-ci5wx26t	247	27	,	,	,
cord-018387-ci5wx26t	247	28	or	or	CC
cord-018387-ci5wx26t	247	29	complex	complex	JJ
cord-018387-ci5wx26t	247	30	action	action	NN
cord-018387-ci5wx26t	247	31	[	[	-LRB-
cord-018387-ci5wx26t	247	32	136	136	CD
cord-018387-ci5wx26t	247	33	]	]	-RRB-
cord-018387-ci5wx26t	247	34	.	.	.
cord-018387-ci5wx26t	248	1	Approaches	approach	NNS
cord-018387-ci5wx26t	248	2	with	with	IN
cord-018387-ci5wx26t	248	3	multiple	multiple	JJ
cord-018387-ci5wx26t	248	4	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	248	5	nutrients	nutrient	NNS
cord-018387-ci5wx26t	248	6	to	to	TO
cord-018387-ci5wx26t	248	7	block	block	VB
cord-018387-ci5wx26t	248	8	the	the	DT
cord-018387-ci5wx26t	248	9	oxidative	oxidative	JJ
cord-018387-ci5wx26t	248	10	stress	stress	NN
cord-018387-ci5wx26t	248	11	related	relate	VBN
cord-018387-ci5wx26t	248	12	to	to	IN
cord-018387-ci5wx26t	248	13	the	the	DT
cord-018387-ci5wx26t	248	14	systemic	systemic	JJ
cord-018387-ci5wx26t	248	15	and	and	CC
cord-018387-ci5wx26t	248	16	brain	brain	NN
cord-018387-ci5wx26t	248	17	inflammation	inflammation	NN
cord-018387-ci5wx26t	248	18	pathways	pathway	NNS
cord-018387-ci5wx26t	249	1	may	may	MD
cord-018387-ci5wx26t	249	2	,	,	,
cord-018387-ci5wx26t	249	3	therefore	therefore	RB
cord-018387-ci5wx26t	249	4	,	,	,
cord-018387-ci5wx26t	249	5	prevent	prevent	VB
cord-018387-ci5wx26t	249	6	or	or	CC
cord-018387-ci5wx26t	249	7	delay	delay	VB
cord-018387-ci5wx26t	249	8	the	the	DT
cord-018387-ci5wx26t	249	9	cognitive	cognitive	JJ
cord-018387-ci5wx26t	249	10	impairments	impairment	NNS
cord-018387-ci5wx26t	249	11	by	by	IN
cord-018387-ci5wx26t	249	12	preventing	prevent	VBG
cord-018387-ci5wx26t	249	13	microglia	microglia	NNS
cord-018387-ci5wx26t	249	14	aging	age	VBG
cord-018387-ci5wx26t	249	15	[	[	-LRB-
cord-018387-ci5wx26t	249	16	137	137	CD
cord-018387-ci5wx26t	249	17	]	]	-RRB-
cord-018387-ci5wx26t	249	18	.	.	.
cord-018387-ci5wx26t	250	1	As	as	IN
cord-018387-ci5wx26t	250	2	a	a	DT
cord-018387-ci5wx26t	250	3	framework	framework	NN
cord-018387-ci5wx26t	250	4	of	of	IN
cord-018387-ci5wx26t	250	5	balanced	balanced	JJ
cord-018387-ci5wx26t	250	6	multicomponent	multicomponent	JJ
cord-018387-ci5wx26t	250	7	diet	diet	NN
cord-018387-ci5wx26t	250	8	strategy	strategy	NN
cord-018387-ci5wx26t	250	9	,	,	,
cord-018387-ci5wx26t	250	10	adherence	adherence	NN
cord-018387-ci5wx26t	250	11	to	to	IN
cord-018387-ci5wx26t	250	12	a	a	DT
cord-018387-ci5wx26t	250	13	Mediterranean	Mediterranean	NNP
cord-018387-ci5wx26t	250	14	diet	diet	NN
cord-018387-ci5wx26t	250	15	enriched	enrich	VBN
cord-018387-ci5wx26t	250	16	with	with	IN
cord-018387-ci5wx26t	250	17	fruits	fruit	NNS
cord-018387-ci5wx26t	250	18	,	,	,
cord-018387-ci5wx26t	250	19	vegetables	vegetable	NNS
cord-018387-ci5wx26t	250	20	,	,	,
cord-018387-ci5wx26t	250	21	nuts	nut	NNS
cord-018387-ci5wx26t	250	22	,	,	,
cord-018387-ci5wx26t	250	23	and	and	CC
cord-018387-ci5wx26t	250	24	unsaturated	unsaturated	JJ
cord-018387-ci5wx26t	250	25	fatty	fatty	JJ
cord-018387-ci5wx26t	250	26	acids	acid	NNS
cord-018387-ci5wx26t	250	27	promotes	promote	VBZ
cord-018387-ci5wx26t	250	28	neuroprotection	neuroprotection	NN
cord-018387-ci5wx26t	250	29	by	by	IN
cord-018387-ci5wx26t	250	30	decreasing	decrease	VBG
cord-018387-ci5wx26t	250	31	inflammation	inflammation	NN
cord-018387-ci5wx26t	250	32	,	,	,
cord-018387-ci5wx26t	250	33	restoring	restore	VBG
cord-018387-ci5wx26t	250	34	cerebral	cerebral	JJ
cord-018387-ci5wx26t	250	35	blood	blood	NN
cord-018387-ci5wx26t	250	36	flow	flow	NN
cord-018387-ci5wx26t	250	37	and	and	CC
cord-018387-ci5wx26t	250	38	volume	volume	NN
cord-018387-ci5wx26t	250	39	,	,	,
cord-018387-ci5wx26t	250	40	inhibiting	inhibit	VBG
cord-018387-ci5wx26t	250	41	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	250	42	,	,	,
cord-018387-ci5wx26t	250	43	and	and	CC
cord-018387-ci5wx26t	250	44	enhancing	enhance	VBG
cord-018387-ci5wx26t	250	45	neural	neural	JJ
cord-018387-ci5wx26t	250	46	plasticity	plasticity	NN
cord-018387-ci5wx26t	250	47	by	by	IN
cord-018387-ci5wx26t	250	48	increasing	increase	VBG
cord-018387-ci5wx26t	250	49	neurogenesis	neurogenesis	NN
cord-018387-ci5wx26t	250	50	[	[	-LRB-
cord-018387-ci5wx26t	250	51	138	138	CD
cord-018387-ci5wx26t	250	52	]	]	-RRB-
cord-018387-ci5wx26t	250	53	.	.	.
cord-018387-ci5wx26t	251	1	Flavonoids	Flavonoids	NNP
cord-018387-ci5wx26t	251	2	,	,	,
cord-018387-ci5wx26t	251	3	plant	plant	NN
cord-018387-ci5wx26t	251	4	polyphenolic	polyphenolic	NN
cord-018387-ci5wx26t	251	5	compounds	compound	NNS
cord-018387-ci5wx26t	251	6	,	,	,
cord-018387-ci5wx26t	251	7	which	which	WDT
cord-018387-ci5wx26t	251	8	are	be	VBP
cord-018387-ci5wx26t	251	9	abundant	abundant	JJ
cord-018387-ci5wx26t	251	10	in	in	IN
cord-018387-ci5wx26t	251	11	fruits	fruit	NNS
cord-018387-ci5wx26t	251	12	and	and	CC
cord-018387-ci5wx26t	251	13	vegetables	vegetable	NNS
cord-018387-ci5wx26t	251	14	,	,	,
cord-018387-ci5wx26t	251	15	exhibit	exhibit	VB
cord-018387-ci5wx26t	251	16	a	a	DT
cord-018387-ci5wx26t	251	17	wide	wide	JJ
cord-018387-ci5wx26t	251	18	variety	variety	NN
cord-018387-ci5wx26t	251	19	of	of	IN
cord-018387-ci5wx26t	251	20	biological	biological	JJ
cord-018387-ci5wx26t	251	21	effects	effect	NNS
cord-018387-ci5wx26t	251	22	,	,	,
cord-018387-ci5wx26t	251	23	including	include	VBG
cord-018387-ci5wx26t	251	24	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	251	25	,	,	,
cord-018387-ci5wx26t	251	26	free	free	JJ
cord-018387-ci5wx26t	251	27	-	-	HYPH
cord-018387-ci5wx26t	251	28	radical	radical	JJ
cord-018387-ci5wx26t	251	29	scavenging	scavenging	NN
cord-018387-ci5wx26t	251	30	,	,	,
cord-018387-ci5wx26t	251	31	and	and	CC
cord-018387-ci5wx26t	251	32	anti	anti	JJ
cord-018387-ci5wx26t	251	33	-	-	JJ
cord-018387-ci5wx26t	251	34	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	251	35	properties	property	NNS
cord-018387-ci5wx26t	251	36	.	.	.
cord-018387-ci5wx26t	252	1	Luteolin	Luteolin	NNP
cord-018387-ci5wx26t	252	2	,	,	,
cord-018387-ci5wx26t	252	3	a	a	DT
cord-018387-ci5wx26t	252	4	flavonoid	flavonoid	NN
cord-018387-ci5wx26t	252	5	found	find	VBN
cord-018387-ci5wx26t	252	6	in	in	IN
cord-018387-ci5wx26t	252	7	high	high	JJ
cord-018387-ci5wx26t	252	8	concentrations	concentration	NNS
cord-018387-ci5wx26t	252	9	in	in	IN
cord-018387-ci5wx26t	252	10	celery	celery	NN
cord-018387-ci5wx26t	252	11	and	and	CC
cord-018387-ci5wx26t	252	12	green	green	JJ
cord-018387-ci5wx26t	252	13	pepper	pepper	NN
cord-018387-ci5wx26t	252	14	,	,	,
cord-018387-ci5wx26t	252	15	has	have	VBZ
cord-018387-ci5wx26t	252	16	been	be	VBN
cord-018387-ci5wx26t	252	17	shown	show	VBN
cord-018387-ci5wx26t	252	18	to	to	TO
cord-018387-ci5wx26t	252	19	reduce	reduce	VB
cord-018387-ci5wx26t	252	20	the	the	DT
cord-018387-ci5wx26t	252	21	production	production	NN
cord-018387-ci5wx26t	252	22	of	of	IN
cord-018387-ci5wx26t	252	23	pro	pro	JJ
cord-018387-ci5wx26t	252	24	-	-	JJ
cord-018387-ci5wx26t	252	25	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	252	26	mediators	mediator	NNS
cord-018387-ci5wx26t	252	27	and	and	CC
cord-018387-ci5wx26t	252	28	to	to	TO
cord-018387-ci5wx26t	252	29	inhibit	inhibit	VB
cord-018387-ci5wx26t	252	30	the	the	DT
cord-018387-ci5wx26t	252	31	JNK	JNK	NNP
cord-018387-ci5wx26t	252	32	and	and	CC
cord-018387-ci5wx26t	252	33	AP-1	AP-1	NNP
cord-018387-ci5wx26t	252	34	signaling	signal	VBG
cord-018387-ci5wx26t	252	35	pathway	pathway	NN
cord-018387-ci5wx26t	252	36	in	in	IN
cord-018387-ci5wx26t	252	37	mice	mouse	NNS
cord-018387-ci5wx26t	252	38	[	[	-LRB-
cord-018387-ci5wx26t	252	39	139	139	CD
cord-018387-ci5wx26t	252	40	]	]	-RRB-
cord-018387-ci5wx26t	252	41	.	.	.
cord-018387-ci5wx26t	253	1	It	-PRON-	PRP
cord-018387-ci5wx26t	253	2	was	be	VBD
cord-018387-ci5wx26t	253	3	therefore	therefore	RB
cord-018387-ci5wx26t	253	4	suggested	suggest	VBN
cord-018387-ci5wx26t	253	5	that	that	IN
cord-018387-ci5wx26t	253	6	luteolin	luteolin	NN
cord-018387-ci5wx26t	253	7	may	may	MD
cord-018387-ci5wx26t	253	8	inhibit	inhibit	VB
cord-018387-ci5wx26t	253	9	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	253	10	and	and	CC
cord-018387-ci5wx26t	253	11	improve	improve	VB
cord-018387-ci5wx26t	253	12	cognition	cognition	NN
cord-018387-ci5wx26t	253	13	in	in	IN
cord-018387-ci5wx26t	253	14	the	the	DT
cord-018387-ci5wx26t	253	15	otherwise	otherwise	RB
cord-018387-ci5wx26t	253	16	healthy	healthy	JJ
cord-018387-ci5wx26t	253	17	aged	age	VBN
cord-018387-ci5wx26t	253	18	by	by	IN
cord-018387-ci5wx26t	253	19	constraining	constrain	VBG
cord-018387-ci5wx26t	253	20	brain	brain	NN
cord-018387-ci5wx26t	253	21	microglia	microglia	NNS
cord-018387-ci5wx26t	253	22	[	[	-LRB-
cord-018387-ci5wx26t	253	23	140	140	CD
cord-018387-ci5wx26t	253	24	]	]	-RRB-
cord-018387-ci5wx26t	253	25	.	.	.
cord-018387-ci5wx26t	254	1	Phenolic	phenolic	JJ
cord-018387-ci5wx26t	254	2	acids	acid	NNS
cord-018387-ci5wx26t	254	3	,	,	,
cord-018387-ci5wx26t	254	4	an	an	DT
cord-018387-ci5wx26t	254	5	important	important	JJ
cord-018387-ci5wx26t	254	6	class	class	NN
cord-018387-ci5wx26t	254	7	of	of	IN
cord-018387-ci5wx26t	254	8	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	254	9	,	,	,
cord-018387-ci5wx26t	254	10	are	be	VBP
cord-018387-ci5wx26t	254	11	abundantly	abundantly	RB
cord-018387-ci5wx26t	254	12	present	present	JJ
cord-018387-ci5wx26t	254	13	in	in	IN
cord-018387-ci5wx26t	254	14	berries	berry	NNS
cord-018387-ci5wx26t	254	15	,	,	,
cord-018387-ci5wx26t	254	16	nuts	nut	NNS
cord-018387-ci5wx26t	254	17	,	,	,
cord-018387-ci5wx26t	254	18	coffee	coffee	NN
cord-018387-ci5wx26t	254	19	,	,	,
cord-018387-ci5wx26t	254	20	tea	tea	NN
cord-018387-ci5wx26t	254	21	,	,	,
cord-018387-ci5wx26t	254	22	and	and	CC
cord-018387-ci5wx26t	254	23	whole	whole	JJ
cord-018387-ci5wx26t	254	24	grains	grain	NNS
cord-018387-ci5wx26t	254	25	.	.	.
cord-018387-ci5wx26t	255	1	They	-PRON-	PRP
cord-018387-ci5wx26t	255	2	exert	exert	VBP
cord-018387-ci5wx26t	255	3	their	-PRON-	PRP$
cord-018387-ci5wx26t	255	4	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	255	5	and	and	CC
cord-018387-ci5wx26t	255	6	anti	anti	JJ
cord-018387-ci5wx26t	255	7	-	-	JJ
cord-018387-ci5wx26t	255	8	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	255	9	activities	activity	NNS
cord-018387-ci5wx26t	255	10	by	by	IN
cord-018387-ci5wx26t	255	11	the	the	DT
cord-018387-ci5wx26t	255	12	attenuation	attenuation	NN
cord-018387-ci5wx26t	255	13	of	of	IN
cord-018387-ci5wx26t	255	14	microglial	microglial	JJ
cord-018387-ci5wx26t	255	15	activation	activation	NN
cord-018387-ci5wx26t	255	16	;	;	:
cord-018387-ci5wx26t	255	17	the	the	DT
cord-018387-ci5wx26t	255	18	significant	significant	JJ
cord-018387-ci5wx26t	255	19	inhibition	inhibition	NN
cord-018387-ci5wx26t	255	20	of	of	IN
cord-018387-ci5wx26t	255	21	the	the	DT
cord-018387-ci5wx26t	255	22	production	production	NN
cord-018387-ci5wx26t	255	23	of	of	IN
cord-018387-ci5wx26t	255	24	TNF	TNF	NNP
cord-018387-ci5wx26t	255	25	,	,	,
cord-018387-ci5wx26t	255	26	IL-6	IL-6	NNP
cord-018387-ci5wx26t	255	27	,	,	,
cord-018387-ci5wx26t	255	28	IL-1β	IL-1β	NNP
cord-018387-ci5wx26t	255	29	,	,	,
cord-018387-ci5wx26t	255	30	and	and	CC
cord-018387-ci5wx26t	255	31	NO	no	NN
cord-018387-ci5wx26t	255	32	;	;	:
cord-018387-ci5wx26t	255	33	and	and	CC
cord-018387-ci5wx26t	255	34	the	the	DT
cord-018387-ci5wx26t	255	35	reduction	reduction	NN
cord-018387-ci5wx26t	255	36	of	of	IN
cord-018387-ci5wx26t	255	37	mRNA	mrna	NN
cord-018387-ci5wx26t	255	38	and	and	CC
cord-018387-ci5wx26t	255	39	protein	protein	NN
cord-018387-ci5wx26t	255	40	levels	level	NNS
cord-018387-ci5wx26t	255	41	of	of	IN
cord-018387-ci5wx26t	255	42	COX-2	COX-2	NNP
cord-018387-ci5wx26t	255	43	and	and	CC
cord-018387-ci5wx26t	255	44	iNOS	inos	JJ
cord-018387-ci5wx26t	255	45	[	[	-LRB-
cord-018387-ci5wx26t	255	46	141	141	CD
cord-018387-ci5wx26t	255	47	]	]	-RRB-
cord-018387-ci5wx26t	255	48	.	.	.
cord-018387-ci5wx26t	256	1	Also	also	RB
cord-018387-ci5wx26t	256	2	,	,	,
cord-018387-ci5wx26t	256	3	retinoids	retinoid	NNS
cord-018387-ci5wx26t	256	4	and	and	CC
cord-018387-ci5wx26t	256	5	carotenoids	carotenoid	NNS
cord-018387-ci5wx26t	256	6	are	be	VBP
cord-018387-ci5wx26t	256	7	known	know	VBN
cord-018387-ci5wx26t	256	8	as	as	IN
cord-018387-ci5wx26t	256	9	potent	potent	JJ
cord-018387-ci5wx26t	256	10	antioxidants	antioxidant	NNS
cord-018387-ci5wx26t	256	11	and	and	CC
cord-018387-ci5wx26t	256	12	anti	anti	JJ
cord-018387-ci5wx26t	256	13	-	-	JJ
cord-018387-ci5wx26t	256	14	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	256	15	agents	agent	NNS
cord-018387-ci5wx26t	256	16	having	have	VBG
cord-018387-ci5wx26t	256	17	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	256	18	properties	property	NNS
cord-018387-ci5wx26t	256	19	[	[	-LRB-
cord-018387-ci5wx26t	256	20	142	142	CD
cord-018387-ci5wx26t	256	21	]	]	-RRB-
cord-018387-ci5wx26t	256	22	.	.	.
cord-018387-ci5wx26t	257	1	Sesamol	Sesamol	NNP
cord-018387-ci5wx26t	257	2	,	,	,
cord-018387-ci5wx26t	257	3	a	a	DT
cord-018387-ci5wx26t	257	4	phenolic	phenolic	JJ
cord-018387-ci5wx26t	257	5	lignan	lignan	NN
cord-018387-ci5wx26t	257	6	from	from	IN
cord-018387-ci5wx26t	257	7	sesame	sesame	NNP
cord-018387-ci5wx26t	257	8	supplementation	supplementation	NN
cord-018387-ci5wx26t	257	9	,	,	,
cord-018387-ci5wx26t	257	10	prevents	prevent	VBZ
cord-018387-ci5wx26t	257	11	systemic	systemic	JJ
cord-018387-ci5wx26t	257	12	inflammation	inflammation	NN
cord-018387-ci5wx26t	257	13	-	-	HYPH
cord-018387-ci5wx26t	257	14	induced	induce	VBN
cord-018387-ci5wx26t	257	15	memory	memory	NN
cord-018387-ci5wx26t	257	16	impairment	impairment	NN
cord-018387-ci5wx26t	257	17	[	[	-LRB-
cord-018387-ci5wx26t	257	18	143	143	CD
cord-018387-ci5wx26t	257	19	]	]	-RRB-
cord-018387-ci5wx26t	257	20	.	.	.
cord-018387-ci5wx26t	258	1	Recently	recently	RB
cord-018387-ci5wx26t	258	2	,	,	,
cord-018387-ci5wx26t	258	3	much	much	JJ
cord-018387-ci5wx26t	258	4	interest	interest	NN
cord-018387-ci5wx26t	258	5	has	have	VBZ
cord-018387-ci5wx26t	258	6	focused	focus	VBN
cord-018387-ci5wx26t	258	7	on	on	IN
cord-018387-ci5wx26t	258	8	the	the	DT
cord-018387-ci5wx26t	258	9	suggested	suggest	VBN
cord-018387-ci5wx26t	258	10	anti	anti	JJ
cord-018387-ci5wx26t	258	11	-	-	JJ
cord-018387-ci5wx26t	258	12	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	258	13	and	and	CC
cord-018387-ci5wx26t	258	14	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	258	15	effects	effect	NNS
cord-018387-ci5wx26t	258	16	of	of	IN
cord-018387-ci5wx26t	258	17	dietary	dietary	JJ
cord-018387-ci5wx26t	258	18	-	-	HYPH
cord-018387-ci5wx26t	258	19	derived	derive	VBN
cord-018387-ci5wx26t	258	20	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	258	21	and	and	CC
cord-018387-ci5wx26t	258	22	the	the	DT
cord-018387-ci5wx26t	258	23	long	long	JJ
cord-018387-ci5wx26t	258	24	-	-	HYPH
cord-018387-ci5wx26t	258	25	chain	chain	NN
cord-018387-ci5wx26t	258	26	n-3	n-3	NN
cord-018387-ci5wx26t	258	27	polyunsaturated	polyunsaturated	JJ
cord-018387-ci5wx26t	258	28	fatty	fatty	JJ
cord-018387-ci5wx26t	258	29	acids	acid	NNS
cord-018387-ci5wx26t	258	30	(	(	-LRB-
cord-018387-ci5wx26t	258	31	PUFA	PUFA	NNP
cord-018387-ci5wx26t	258	32	)	)	-RRB-
cord-018387-ci5wx26t	258	33	,	,	,
cord-018387-ci5wx26t	258	34	eicosapentaenoic	eicosapentaenoic	JJ
cord-018387-ci5wx26t	258	35	acid	acid	NN
cord-018387-ci5wx26t	258	36	(	(	-LRB-
cord-018387-ci5wx26t	258	37	EPA	EPA	NNP
cord-018387-ci5wx26t	258	38	)	)	-RRB-
cord-018387-ci5wx26t	258	39	,	,	,
cord-018387-ci5wx26t	258	40	and	and	CC
cord-018387-ci5wx26t	258	41	docosahexaenoic	docosahexaenoic	NNP
cord-018387-ci5wx26t	258	42	acid	acid	NNP
cord-018387-ci5wx26t	258	43	(	(	-LRB-
cord-018387-ci5wx26t	258	44	DHA	DHA	NNP
cord-018387-ci5wx26t	258	45	)	)	-RRB-
cord-018387-ci5wx26t	258	46	,	,	,
cord-018387-ci5wx26t	258	47	rendering	render	VBG
cord-018387-ci5wx26t	258	48	these	these	DT
cord-018387-ci5wx26t	258	49	molecules	molecule	NNS
cord-018387-ci5wx26t	258	50	as	as	IN
cord-018387-ci5wx26t	258	51	potential	potential	JJ
cord-018387-ci5wx26t	258	52	candidates	candidate	NNS
cord-018387-ci5wx26t	258	53	for	for	IN
cord-018387-ci5wx26t	258	54	use	use	NN
cord-018387-ci5wx26t	258	55	in	in	IN
cord-018387-ci5wx26t	258	56	preventative	preventative	JJ
cord-018387-ci5wx26t	258	57	and	and	CC
cord-018387-ci5wx26t	258	58	therapeutic	therapeutic	JJ
cord-018387-ci5wx26t	258	59	strategies	strategy	NNS
cord-018387-ci5wx26t	258	60	to	to	TO
cord-018387-ci5wx26t	258	61	reduce	reduce	VB
cord-018387-ci5wx26t	258	62	the	the	DT
cord-018387-ci5wx26t	258	63	risk	risk	NN
cord-018387-ci5wx26t	258	64	of	of	IN
cord-018387-ci5wx26t	258	65	age	age	NN
cord-018387-ci5wx26t	258	66	-	-	HYPH
cord-018387-ci5wx26t	258	67	related	relate	VBN
cord-018387-ci5wx26t	258	68	chronic	chronic	NN
cord-018387-ci5wx26t	258	69	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	258	70	diseases	disease	NNS
cord-018387-ci5wx26t	258	71	[	[	-LRB-
cord-018387-ci5wx26t	258	72	144	144	CD
cord-018387-ci5wx26t	258	73	]	]	-RRB-
cord-018387-ci5wx26t	259	1	[	[	-LRB-
cord-018387-ci5wx26t	259	2	145	145	CD
cord-018387-ci5wx26t	259	3	]	]	-RRB-
cord-018387-ci5wx26t	259	4	[	[	-LRB-
cord-018387-ci5wx26t	259	5	146	146	CD
cord-018387-ci5wx26t	259	6	]	]	-RRB-
cord-018387-ci5wx26t	259	7	.	.	.
cord-018387-ci5wx26t	260	1	Both	both	DT
cord-018387-ci5wx26t	260	2	DHA	DHA	NNP
cord-018387-ci5wx26t	260	3	and	and	CC
cord-018387-ci5wx26t	260	4	EPA	EPA	NNP
cord-018387-ci5wx26t	260	5	can	can	MD
cord-018387-ci5wx26t	260	6	reduce	reduce	VB
cord-018387-ci5wx26t	260	7	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	260	8	and	and	CC
cord-018387-ci5wx26t	260	9	cognitive	cognitive	JJ
cord-018387-ci5wx26t	260	10	decline	decline	NN
cord-018387-ci5wx26t	260	11	.	.	.
cord-018387-ci5wx26t	261	1	In	in	IN
cord-018387-ci5wx26t	261	2	particular	particular	JJ
cord-018387-ci5wx26t	261	3	,	,	,
cord-018387-ci5wx26t	261	4	it	-PRON-	PRP
cord-018387-ci5wx26t	261	5	has	have	VBZ
cord-018387-ci5wx26t	261	6	been	be	VBN
cord-018387-ci5wx26t	261	7	demonstrated	demonstrate	VBN
cord-018387-ci5wx26t	261	8	that	that	IN
cord-018387-ci5wx26t	261	9	EPA	EPA	NNP
cord-018387-ci5wx26t	261	10	positively	positively	RB
cord-018387-ci5wx26t	261	11	influences	influence	VBZ
cord-018387-ci5wx26t	261	12	mood	mood	NN
cord-018387-ci5wx26t	261	13	disorders	disorder	NNS
cord-018387-ci5wx26t	261	14	and	and	CC
cord-018387-ci5wx26t	261	15	DHA	DHA	NNP
cord-018387-ci5wx26t	261	16	maintains	maintain	VBZ
cord-018387-ci5wx26t	261	17	normal	normal	JJ
cord-018387-ci5wx26t	261	18	brain	brain	NN
cord-018387-ci5wx26t	261	19	structure	structure	NN
cord-018387-ci5wx26t	261	20	[	[	-LRB-
cord-018387-ci5wx26t	261	21	147	147	CD
cord-018387-ci5wx26t	261	22	]	]	-RRB-
cord-018387-ci5wx26t	261	23	.	.	.
cord-018387-ci5wx26t	262	1	Supplementation	supplementation	NN
cord-018387-ci5wx26t	262	2	with	with	IN
cord-018387-ci5wx26t	262	3	EPA	EPA	NNP
cord-018387-ci5wx26t	262	4	may	may	MD
cord-018387-ci5wx26t	262	5	attenuate	attenuate	VB
cord-018387-ci5wx26t	262	6	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	262	7	by	by	IN
cord-018387-ci5wx26t	262	8	inhibiting	inhibit	VBG
cord-018387-ci5wx26t	262	9	microglial	microglial	JJ
cord-018387-ci5wx26t	262	10	activation	activation	NN
cord-018387-ci5wx26t	262	11	and	and	CC
cord-018387-ci5wx26t	262	12	microgliaproduced	microgliaproduce	VBD
cord-018387-ci5wx26t	262	13	pro	pro	JJ
cord-018387-ci5wx26t	262	14	-	-	JJ
cord-018387-ci5wx26t	262	15	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	262	16	cytokines	cytokine	NNS
cord-018387-ci5wx26t	262	17	and	and	CC
cord-018387-ci5wx26t	262	18	by	by	IN
cord-018387-ci5wx26t	262	19	enhancing	enhance	VBG
cord-018387-ci5wx26t	262	20	the	the	DT
cord-018387-ci5wx26t	262	21	expression	expression	NN
cord-018387-ci5wx26t	262	22	of	of	IN
cord-018387-ci5wx26t	262	23	astrocyte	astrocyte	RB
cord-018387-ci5wx26t	262	24	-	-	HYPH
cord-018387-ci5wx26t	262	25	produced	produce	VBN
cord-018387-ci5wx26t	262	26	neurotrophins	neurotrophin	NNS
cord-018387-ci5wx26t	262	27	and	and	CC
cord-018387-ci5wx26t	262	28	their	-PRON-	PRP$
cord-018387-ci5wx26t	262	29	receptors	receptor	NNS
cord-018387-ci5wx26t	262	30	[	[	-LRB-
cord-018387-ci5wx26t	262	31	148	148	CD
cord-018387-ci5wx26t	262	32	]	]	-RRB-
cord-018387-ci5wx26t	262	33	.	.	.
cord-018387-ci5wx26t	263	1	In	in	IN
cord-018387-ci5wx26t	263	2	general	general	JJ
cord-018387-ci5wx26t	263	3	,	,	,
cord-018387-ci5wx26t	263	4	many	many	JJ
cord-018387-ci5wx26t	263	5	studies	study	NNS
cord-018387-ci5wx26t	263	6	with	with	IN
cord-018387-ci5wx26t	263	7	animal	animal	NN
cord-018387-ci5wx26t	263	8	models	model	NNS
cord-018387-ci5wx26t	263	9	support	support	VBP
cord-018387-ci5wx26t	263	10	the	the	DT
cord-018387-ci5wx26t	263	11	protective	protective	JJ
cord-018387-ci5wx26t	263	12	effects	effect	NNS
cord-018387-ci5wx26t	263	13	of	of	IN
cord-018387-ci5wx26t	263	14	n-3	n-3	NN
cord-018387-ci5wx26t	263	15	PUFA	PUFA	NNP
cord-018387-ci5wx26t	263	16	supplementation	supplementation	NN
cord-018387-ci5wx26t	263	17	under	under	IN
cord-018387-ci5wx26t	263	18	different	different	JJ
cord-018387-ci5wx26t	263	19	conditions	condition	NNS
cord-018387-ci5wx26t	263	20	.	.	.
cord-018387-ci5wx26t	264	1	However	however	RB
cord-018387-ci5wx26t	264	2	,	,	,
cord-018387-ci5wx26t	264	3	studies	study	NNS
cord-018387-ci5wx26t	264	4	to	to	TO
cord-018387-ci5wx26t	264	5	demonstrate	demonstrate	VB
cord-018387-ci5wx26t	264	6	clear	clear	JJ
cord-018387-ci5wx26t	264	7	benefits	benefit	NNS
cord-018387-ci5wx26t	264	8	on	on	IN
cord-018387-ci5wx26t	264	9	human	human	JJ
cord-018387-ci5wx26t	264	10	subjects	subject	NNS
cord-018387-ci5wx26t	264	11	toward	toward	IN
cord-018387-ci5wx26t	264	12	a	a	DT
cord-018387-ci5wx26t	264	13	particular	particular	JJ
cord-018387-ci5wx26t	264	14	disease	disease	NN
cord-018387-ci5wx26t	264	15	have	have	VBP
cord-018387-ci5wx26t	264	16	not	not	RB
cord-018387-ci5wx26t	264	17	been	be	VBN
cord-018387-ci5wx26t	264	18	conclusive	conclusive	JJ
cord-018387-ci5wx26t	264	19	,	,	,
cord-018387-ci5wx26t	264	20	probably	probably	RB
cord-018387-ci5wx26t	264	21	due	due	IN
cord-018387-ci5wx26t	264	22	to	to	IN
cord-018387-ci5wx26t	264	23	heterogeneous	heterogeneous	JJ
cord-018387-ci5wx26t	264	24	dietary	dietary	JJ
cord-018387-ci5wx26t	264	25	habits	habit	NNS
cord-018387-ci5wx26t	264	26	and	and	CC
cord-018387-ci5wx26t	264	27	the	the	DT
cord-018387-ci5wx26t	264	28	population	population	NN
cord-018387-ci5wx26t	264	29	being	be	VBG
cord-018387-ci5wx26t	264	30	in	in	IN
cord-018387-ci5wx26t	264	31	different	different	JJ
cord-018387-ci5wx26t	264	32	demographic	demographic	JJ
cord-018387-ci5wx26t	264	33	conditions	condition	NNS
cord-018387-ci5wx26t	264	34	.	.	.
cord-018387-ci5wx26t	265	1	Since	since	IN
cord-018387-ci5wx26t	265	2	many	many	JJ
cord-018387-ci5wx26t	265	3	botanical	botanical	JJ
cord-018387-ci5wx26t	265	4	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	265	5	can	can	MD
cord-018387-ci5wx26t	265	6	also	also	RB
cord-018387-ci5wx26t	265	7	up	up	RB
cord-018387-ci5wx26t	265	8	-	-	:
cord-018387-ci5wx26t	265	9	and	and	CC
cord-018387-ci5wx26t	265	10	downregulate	downregulate	VB
cord-018387-ci5wx26t	265	11	the	the	DT
cord-018387-ci5wx26t	265	12	same	same	JJ
cord-018387-ci5wx26t	265	13	pathways	pathway	NNS
cord-018387-ci5wx26t	265	14	,	,	,
cord-018387-ci5wx26t	265	15	future	future	JJ
cord-018387-ci5wx26t	265	16	studies	study	NNS
cord-018387-ci5wx26t	265	17	may	may	MD
cord-018387-ci5wx26t	265	18	need	need	VB
cord-018387-ci5wx26t	265	19	to	to	TO
cord-018387-ci5wx26t	265	20	include	include	VB
cord-018387-ci5wx26t	265	21	testing	testing	NN
cord-018387-ci5wx26t	265	22	for	for	IN
cord-018387-ci5wx26t	265	23	combined	combined	JJ
cord-018387-ci5wx26t	265	24	effects	effect	NNS
cord-018387-ci5wx26t	265	25	of	of	IN
cord-018387-ci5wx26t	265	26	DHA	DHA	NNP
cord-018387-ci5wx26t	265	27	and	and	CC
cord-018387-ci5wx26t	265	28	these	these	DT
cord-018387-ci5wx26t	265	29	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	265	30	[	[	-LRB-
cord-018387-ci5wx26t	265	31	149	149	CD
cord-018387-ci5wx26t	265	32	]	]	-RRB-
cord-018387-ci5wx26t	265	33	.	.	.
cord-018387-ci5wx26t	266	1	Thus	thus	RB
cord-018387-ci5wx26t	266	2	,	,	,
cord-018387-ci5wx26t	266	3	more	more	RBR
cord-018387-ci5wx26t	266	4	clinical	clinical	JJ
cord-018387-ci5wx26t	266	5	studies	study	NNS
cord-018387-ci5wx26t	266	6	are	be	VBP
cord-018387-ci5wx26t	266	7	needed	need	VBN
cord-018387-ci5wx26t	266	8	to	to	TO
cord-018387-ci5wx26t	266	9	determine	determine	VB
cord-018387-ci5wx26t	266	10	the	the	DT
cord-018387-ci5wx26t	266	11	amounts	amount	NNS
cord-018387-ci5wx26t	266	12	of	of	IN
cord-018387-ci5wx26t	266	13	dietary	dietary	JJ
cord-018387-ci5wx26t	266	14	agents	agent	NNS
cord-018387-ci5wx26t	266	15	needed	need	VBN
cord-018387-ci5wx26t	266	16	to	to	TO
cord-018387-ci5wx26t	266	17	delay	delay	VB
cord-018387-ci5wx26t	266	18	aging	age	VBG
cord-018387-ci5wx26t	266	19	and	and	CC
cord-018387-ci5wx26t	266	20	agerelated	agerelated	JJ
cord-018387-ci5wx26t	266	21	diseases	disease	NNS
cord-018387-ci5wx26t	266	22	and	and	CC
cord-018387-ci5wx26t	266	23	to	to	TO
cord-018387-ci5wx26t	266	24	investigate	investigate	VB
cord-018387-ci5wx26t	266	25	their	-PRON-	PRP$
cord-018387-ci5wx26t	266	26	effects	effect	NNS
cord-018387-ci5wx26t	266	27	on	on	IN
cord-018387-ci5wx26t	266	28	different	different	JJ
cord-018387-ci5wx26t	266	29	age	age	NN
cord-018387-ci5wx26t	266	30	groups	group	NNS
cord-018387-ci5wx26t	266	31	[	[	-LRB-
cord-018387-ci5wx26t	266	32	107	107	CD
cord-018387-ci5wx26t	266	33	]	]	-RRB-
cord-018387-ci5wx26t	266	34	.	.	.
cord-018387-ci5wx26t	267	1	Furthermore	furthermore	RB
cord-018387-ci5wx26t	267	2	,	,	,
cord-018387-ci5wx26t	267	3	when	when	WRB
cord-018387-ci5wx26t	267	4	identifying	identify	VBG
cord-018387-ci5wx26t	267	5	dietary	dietary	JJ
cord-018387-ci5wx26t	267	6	approaches	approach	NNS
cord-018387-ci5wx26t	267	7	to	to	TO
cord-018387-ci5wx26t	267	8	promote	promote	VB
cord-018387-ci5wx26t	267	9	healthy	healthy	JJ
cord-018387-ci5wx26t	267	10	brain	brain	NN
cord-018387-ci5wx26t	267	11	aging	aging	NN
cord-018387-ci5wx26t	267	12	,	,	,
cord-018387-ci5wx26t	267	13	a	a	DT
cord-018387-ci5wx26t	267	14	holistic	holistic	JJ
cord-018387-ci5wx26t	267	15	approach	approach	NN
cord-018387-ci5wx26t	267	16	should	should	MD
cord-018387-ci5wx26t	267	17	be	be	VB
cord-018387-ci5wx26t	267	18	considered	consider	VBN
cord-018387-ci5wx26t	267	19	,	,	,
cord-018387-ci5wx26t	267	20	including	include	VBG
cord-018387-ci5wx26t	267	21	nutrition	nutrition	NN
cord-018387-ci5wx26t	267	22	,	,	,
cord-018387-ci5wx26t	267	23	exercise	exercise	NN
cord-018387-ci5wx26t	267	24	,	,	,
cord-018387-ci5wx26t	267	25	and	and	CC
cord-018387-ci5wx26t	267	26	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	267	27	factors	factor	NNS
cord-018387-ci5wx26t	267	28	,	,	,
cord-018387-ci5wx26t	267	29	which	which	WDT
cord-018387-ci5wx26t	267	30	not	not	RB
cord-018387-ci5wx26t	267	31	only	only	RB
cord-018387-ci5wx26t	267	32	target	target	VBP
cord-018387-ci5wx26t	267	33	the	the	DT
cord-018387-ci5wx26t	267	34	brain	brain	NN
cord-018387-ci5wx26t	267	35	but	but	CC
cord-018387-ci5wx26t	267	36	also	also	RB
cord-018387-ci5wx26t	267	37	overall	overall	JJ
cord-018387-ci5wx26t	267	38	cardiovascular	cardiovascular	JJ
cord-018387-ci5wx26t	267	39	,	,	,
cord-018387-ci5wx26t	267	40	immune	immune	JJ
cord-018387-ci5wx26t	267	41	,	,	,
cord-018387-ci5wx26t	267	42	and	and	CC
cord-018387-ci5wx26t	267	43	metabolic	metabolic	JJ
cord-018387-ci5wx26t	267	44	health	health	NN
cord-018387-ci5wx26t	267	45	[	[	-LRB-
cord-018387-ci5wx26t	267	46	144	144	CD
cord-018387-ci5wx26t	267	47	]	]	-RRB-
cord-018387-ci5wx26t	267	48	.	.	.
cord-018387-ci5wx26t	268	1	Several	several	JJ
cord-018387-ci5wx26t	268	2	interventions	intervention	NNS
cord-018387-ci5wx26t	268	3	,	,	,
cord-018387-ci5wx26t	268	4	including	include	VBG
cord-018387-ci5wx26t	268	5	different	different	JJ
cord-018387-ci5wx26t	268	6	types	type	NNS
cord-018387-ci5wx26t	268	7	of	of	IN
cord-018387-ci5wx26t	268	8	exercises	exercise	NNS
cord-018387-ci5wx26t	268	9	,	,	,
cord-018387-ci5wx26t	268	10	have	have	VBP
cord-018387-ci5wx26t	268	11	been	be	VBN
cord-018387-ci5wx26t	268	12	proposed	propose	VBN
cord-018387-ci5wx26t	268	13	to	to	TO
cord-018387-ci5wx26t	268	14	restore	restore	VB
cord-018387-ci5wx26t	268	15	immune	immune	JJ
cord-018387-ci5wx26t	268	16	and	and	CC
cord-018387-ci5wx26t	268	17	neural	neural	JJ
cord-018387-ci5wx26t	268	18	functions	function	NNS
cord-018387-ci5wx26t	268	19	in	in	IN
cord-018387-ci5wx26t	268	20	elderly	elderly	JJ
cord-018387-ci5wx26t	268	21	people	people	NNS
cord-018387-ci5wx26t	268	22	.	.	.
cord-018387-ci5wx26t	269	1	Physical	physical	JJ
cord-018387-ci5wx26t	269	2	exercise	exercise	NN
cord-018387-ci5wx26t	269	3	and	and	CC
cord-018387-ci5wx26t	269	4	physical	physical	JJ
cord-018387-ci5wx26t	269	5	activity	activity	NN
cord-018387-ci5wx26t	269	6	in	in	IN
cord-018387-ci5wx26t	269	7	later	later	JJ
cord-018387-ci5wx26t	269	8	life	life	NN
cord-018387-ci5wx26t	269	9	might	may	MD
cord-018387-ci5wx26t	269	10	target	target	VB
cord-018387-ci5wx26t	269	11	modifiable	modifiable	JJ
cord-018387-ci5wx26t	269	12	risk	risk	NN
cord-018387-ci5wx26t	269	13	factors	factor	NNS
cord-018387-ci5wx26t	269	14	of	of	IN
cord-018387-ci5wx26t	269	15	aging	age	VBG
cord-018387-ci5wx26t	269	16	,	,	,
cord-018387-ci5wx26t	269	17	such	such	JJ
cord-018387-ci5wx26t	269	18	as	as	IN
cord-018387-ci5wx26t	269	19	low	low	JJ
cord-018387-ci5wx26t	269	20	-	-	HYPH
cord-018387-ci5wx26t	269	21	grade	grade	NN
cord-018387-ci5wx26t	269	22	inflammation	inflammation	NN
cord-018387-ci5wx26t	269	23	,	,	,
cord-018387-ci5wx26t	269	24	inducing	induce	VBG
cord-018387-ci5wx26t	269	25	immunoprotective	immunoprotective	JJ
cord-018387-ci5wx26t	269	26	and	and	CC
cord-018387-ci5wx26t	269	27	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	269	28	functions	function	NNS
cord-018387-ci5wx26t	269	29	(	(	-LRB-
cord-018387-ci5wx26t	269	30	Fig	Fig	NNP
cord-018387-ci5wx26t	269	31	.	.	.
cord-018387-ci5wx26t	269	32	14.5	14.5	CD
cord-018387-ci5wx26t	269	33	)	)	-RRB-
cord-018387-ci5wx26t	270	1	[	[	-LRB-
cord-018387-ci5wx26t	270	2	150	150	CD
cord-018387-ci5wx26t	270	3	,	,	,
cord-018387-ci5wx26t	270	4	151	151	CD
cord-018387-ci5wx26t	270	5	]	]	-RRB-
cord-018387-ci5wx26t	270	6	.	.	.
cord-018387-ci5wx26t	271	1	Numerous	numerous	JJ
cord-018387-ci5wx26t	271	2	studies	study	NNS
cord-018387-ci5wx26t	271	3	have	have	VBP
cord-018387-ci5wx26t	271	4	revealed	reveal	VBN
cord-018387-ci5wx26t	271	5	the	the	DT
cord-018387-ci5wx26t	271	6	anti	anti	JJ
cord-018387-ci5wx26t	271	7	-	-	JJ
cord-018387-ci5wx26t	271	8	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	271	9	and	and	CC
cord-018387-ci5wx26t	271	10	antioxidative	antioxidative	JJ
cord-018387-ci5wx26t	271	11	effects	effect	NNS
cord-018387-ci5wx26t	271	12	following	follow	VBG
cord-018387-ci5wx26t	271	13	physical	physical	JJ
cord-018387-ci5wx26t	271	14	activity	activity	NN
cord-018387-ci5wx26t	271	15	(	(	-LRB-
cord-018387-ci5wx26t	271	16	Figs	fig	NNS
cord-018387-ci5wx26t	271	17	.	.	.
cord-018387-ci5wx26t	272	1	14.4	14.4	CD
cord-018387-ci5wx26t	272	2	and	and	CC
cord-018387-ci5wx26t	272	3	14.5	14.5	CD
cord-018387-ci5wx26t	272	4	)	)	-RRB-
cord-018387-ci5wx26t	272	5	,	,	,
cord-018387-ci5wx26t	272	6	which	which	WDT
cord-018387-ci5wx26t	272	7	potentially	potentially	RB
cord-018387-ci5wx26t	272	8	exert	exert	VBP
cord-018387-ci5wx26t	272	9	beneficial	beneficial	JJ
cord-018387-ci5wx26t	272	10	effects	effect	NNS
cord-018387-ci5wx26t	272	11	on	on	IN
cord-018387-ci5wx26t	272	12	neuroplasticity	neuroplasticity	NN
cord-018387-ci5wx26t	272	13	,	,	,
cord-018387-ci5wx26t	272	14	affect	affect	VB
cord-018387-ci5wx26t	272	15	the	the	DT
cord-018387-ci5wx26t	272	16	expression	expression	NN
cord-018387-ci5wx26t	272	17	of	of	IN
cord-018387-ci5wx26t	272	18	neurotrophins	neurotrophins	NNP
cord-018387-ci5wx26t	272	19	,	,	,
cord-018387-ci5wx26t	272	20	and	and	CC
cord-018387-ci5wx26t	272	21	therefore	therefore	RB
cord-018387-ci5wx26t	272	22	help	help	VBP
cord-018387-ci5wx26t	272	23	to	to	TO
cord-018387-ci5wx26t	272	24	maintain	maintain	VB
cord-018387-ci5wx26t	272	25	normal	normal	JJ
cord-018387-ci5wx26t	272	26	neuronal	neuronal	JJ
cord-018387-ci5wx26t	272	27	functions	function	NNS
cord-018387-ci5wx26t	272	28	[	[	-LRB-
cord-018387-ci5wx26t	272	29	152	152	CD
cord-018387-ci5wx26t	272	30	]	]	-RRB-
cord-018387-ci5wx26t	272	31	.	.	.
cord-018387-ci5wx26t	273	1	Barrientos	barrientos	NN
cord-018387-ci5wx26t	273	2	and	and	CC
cord-018387-ci5wx26t	273	3	colleagues	colleague	NNS
cord-018387-ci5wx26t	273	4	observed	observe	VBD
cord-018387-ci5wx26t	273	5	an	an	DT
cord-018387-ci5wx26t	273	6	inhibition	inhibition	NN
cord-018387-ci5wx26t	273	7	of	of	IN
cord-018387-ci5wx26t	273	8	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	273	9	(	(	-LRB-
cord-018387-ci5wx26t	273	10	caused	cause	VBN
cord-018387-ci5wx26t	273	11	by	by	IN
cord-018387-ci5wx26t	273	12	infection	infection	NN
cord-018387-ci5wx26t	273	13	)	)	-RRB-
cord-018387-ci5wx26t	273	14	in	in	IN
cord-018387-ci5wx26t	273	15	rats	rat	NNS
cord-018387-ci5wx26t	273	16	performing	perform	VBG
cord-018387-ci5wx26t	273	17	exercises	exercise	NNS
cord-018387-ci5wx26t	273	18	and	and	CC
cord-018387-ci5wx26t	273	19	an	an	DT
cord-018387-ci5wx26t	273	20	increased	increase	VBN
cord-018387-ci5wx26t	273	21	induction	induction	NN
cord-018387-ci5wx26t	273	22	of	of	IN
cord-018387-ci5wx26t	273	23	BDNF	BDNF	NNP
cord-018387-ci5wx26t	273	24	mRNA	mRNA	NNP
cord-018387-ci5wx26t	273	25	in	in	IN
cord-018387-ci5wx26t	273	26	the	the	DT
cord-018387-ci5wx26t	273	27	brain	brain	NN
cord-018387-ci5wx26t	273	28	of	of	IN
cord-018387-ci5wx26t	273	29	otherwise	otherwise	RB
cord-018387-ci5wx26t	273	30	sedentary	sedentary	JJ
cord-018387-ci5wx26t	273	31	animals	animal	NNS
cord-018387-ci5wx26t	273	32	[	[	-LRB-
cord-018387-ci5wx26t	273	33	153	153	CD
cord-018387-ci5wx26t	273	34	]	]	-RRB-
cord-018387-ci5wx26t	273	35	.	.	.
cord-018387-ci5wx26t	274	1	Further	further	JJ
cord-018387-ci5wx26t	274	2	studies	study	NNS
cord-018387-ci5wx26t	274	3	with	with	IN
cord-018387-ci5wx26t	274	4	aged	aged	JJ
cord-018387-ci5wx26t	274	5	mice	mouse	NNS
cord-018387-ci5wx26t	274	6	revealed	reveal	VBD
cord-018387-ci5wx26t	274	7	that	that	IN
cord-018387-ci5wx26t	274	8	wheel	wheel	NN
cord-018387-ci5wx26t	274	9	running	running	NN
cord-018387-ci5wx26t	274	10	inhibits	inhibit	VBZ
cord-018387-ci5wx26t	274	11	the	the	DT
cord-018387-ci5wx26t	274	12	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	274	13	state	state	NN
cord-018387-ci5wx26t	274	14	of	of	IN
cord-018387-ci5wx26t	274	15	microglia	microglia	NN
cord-018387-ci5wx26t	274	16	and	and	CC
cord-018387-ci5wx26t	274	17	their	-PRON-	PRP$
cord-018387-ci5wx26t	274	18	ability	ability	NN
cord-018387-ci5wx26t	274	19	to	to	TO
cord-018387-ci5wx26t	274	20	proliferate	proliferate	VB
cord-018387-ci5wx26t	274	21	,	,	,
cord-018387-ci5wx26t	274	22	thus	thus	RB
cord-018387-ci5wx26t	274	23	inducing	induce	VBG
cord-018387-ci5wx26t	274	24	a	a	DT
cord-018387-ci5wx26t	274	25	pro	pro	JJ
cord-018387-ci5wx26t	274	26	-	-	JJ
cord-018387-ci5wx26t	274	27	neurogenic	neurogenic	JJ
cord-018387-ci5wx26t	274	28	phenotype	phenotype	NN
cord-018387-ci5wx26t	274	29	[	[	-LRB-
cord-018387-ci5wx26t	274	30	154	154	CD
cord-018387-ci5wx26t	274	31	]	]	-RRB-
cord-018387-ci5wx26t	274	32	.	.	.
cord-018387-ci5wx26t	275	1	Certainly	certainly	RB
cord-018387-ci5wx26t	275	2	,	,	,
cord-018387-ci5wx26t	275	3	the	the	DT
cord-018387-ci5wx26t	275	4	anti	anti	JJ
cord-018387-ci5wx26t	275	5	-	-	JJ
cord-018387-ci5wx26t	275	6	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	275	7	effects	effect	NNS
cord-018387-ci5wx26t	275	8	of	of	IN
cord-018387-ci5wx26t	275	9	exercise	exercise	NN
cord-018387-ci5wx26t	275	10	are	be	VBP
cord-018387-ci5wx26t	275	11	mediated	mediate	VBN
cord-018387-ci5wx26t	275	12	through	through	IN
cord-018387-ci5wx26t	275	13	multidirectional	multidirectional	JJ
cord-018387-ci5wx26t	275	14	pathways	pathway	NNS
cord-018387-ci5wx26t	275	15	.	.	.
cord-018387-ci5wx26t	276	1	Some	some	DT
cord-018387-ci5wx26t	276	2	of	of	IN
cord-018387-ci5wx26t	276	3	them	-PRON-	PRP
cord-018387-ci5wx26t	276	4	are	be	VBP
cord-018387-ci5wx26t	276	5	exerted	exert	VBN
cord-018387-ci5wx26t	276	6	on	on	IN
cord-018387-ci5wx26t	276	7	adipose	adipose	JJ
cord-018387-ci5wx26t	276	8	tissue	tissue	NN
cord-018387-ci5wx26t	276	9	,	,	,
cord-018387-ci5wx26t	276	10	skeletal	skeletal	JJ
cord-018387-ci5wx26t	276	11	muscles	muscle	NNS
cord-018387-ci5wx26t	276	12	,	,	,
cord-018387-ci5wx26t	276	13	immune	immune	JJ
cord-018387-ci5wx26t	276	14	system	system	NN
cord-018387-ci5wx26t	276	15	cells	cell	NNS
cord-018387-ci5wx26t	276	16	,	,	,
cord-018387-ci5wx26t	276	17	and	and	CC
cord-018387-ci5wx26t	276	18	the	the	DT
cord-018387-ci5wx26t	276	19	cardiovascular	cardiovascular	JJ
cord-018387-ci5wx26t	276	20	system	system	NN
cord-018387-ci5wx26t	276	21	(	(	-LRB-
cord-018387-ci5wx26t	276	22	Figs	fig	NNS
cord-018387-ci5wx26t	276	23	.	.	.
cord-018387-ci5wx26t	277	1	14.4	14.4	CD
cord-018387-ci5wx26t	277	2	and	and	CC
cord-018387-ci5wx26t	277	3	14.5	14.5	CD
cord-018387-ci5wx26t	277	4	)	)	-RRB-
cord-018387-ci5wx26t	277	5	.	.	.
cord-018387-ci5wx26t	278	1	These	these	DT
cord-018387-ci5wx26t	278	2	effects	effect	NNS
cord-018387-ci5wx26t	278	3	include	include	VBP
cord-018387-ci5wx26t	278	4	the	the	DT
cord-018387-ci5wx26t	278	5	modulation	modulation	NN
cord-018387-ci5wx26t	278	6	of	of	IN
cord-018387-ci5wx26t	278	7	anti	anti	JJ
cord-018387-ci5wx26t	278	8	-	-	JJ
cord-018387-ci5wx26t	278	9	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	278	10	and	and	CC
cord-018387-ci5wx26t	278	11	pro	pro	JJ
cord-018387-ci5wx26t	278	12	-	-	JJ
cord-018387-ci5wx26t	278	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	278	14	cytokine	cytokine	NN
cord-018387-ci5wx26t	278	15	profiles	profile	NNS
cord-018387-ci5wx26t	278	16	,	,	,
cord-018387-ci5wx26t	278	17	redox	redox	NN
cord-018387-ci5wx26t	278	18	-	-	HYPH
cord-018387-ci5wx26t	278	19	sensitive	sensitive	JJ
cord-018387-ci5wx26t	278	20	transcription	transcription	NN
cord-018387-ci5wx26t	278	21	factors	factor	NNS
cord-018387-ci5wx26t	278	22	,	,	,
cord-018387-ci5wx26t	278	23	and	and	CC
cord-018387-ci5wx26t	278	24	antioxidant	antioxidant	NN
cord-018387-ci5wx26t	278	25	and	and	CC
cord-018387-ci5wx26t	278	26	prooxidant	prooxidant	JJ
cord-018387-ci5wx26t	278	27	enzymes	enzyme	NNS
cord-018387-ci5wx26t	278	28	and	and	CC
cord-018387-ci5wx26t	278	29	repair	repair	NN
cord-018387-ci5wx26t	278	30	proteins	protein	NNS
cord-018387-ci5wx26t	278	31	[	[	-LRB-
cord-018387-ci5wx26t	278	32	155	155	CD
cord-018387-ci5wx26t	278	33	]	]	-RRB-
cord-018387-ci5wx26t	278	34	.	.	.
cord-018387-ci5wx26t	279	1	Regular	regular	JJ
cord-018387-ci5wx26t	279	2	physical	physical	JJ
cord-018387-ci5wx26t	279	3	activity	activity	NN
cord-018387-ci5wx26t	279	4	combined	combine	VBN
cord-018387-ci5wx26t	279	5	with	with	IN
cord-018387-ci5wx26t	279	6	nutritional	nutritional	JJ
cord-018387-ci5wx26t	279	7	interventions	intervention	NNS
cord-018387-ci5wx26t	279	8	can	can	MD
cord-018387-ci5wx26t	279	9	reduce	reduce	VB
cord-018387-ci5wx26t	279	10	the	the	DT
cord-018387-ci5wx26t	279	11	size	size	NN
cord-018387-ci5wx26t	279	12	of	of	IN
cord-018387-ci5wx26t	279	13	adipocytes	adipocyte	NNS
cord-018387-ci5wx26t	279	14	and	and	CC
cord-018387-ci5wx26t	279	15	attenuate	attenuate	VB
cord-018387-ci5wx26t	279	16	inflammation	inflammation	NN
cord-018387-ci5wx26t	279	17	in	in	IN
cord-018387-ci5wx26t	279	18	adipose	adipose	JJ
cord-018387-ci5wx26t	279	19	tissue	tissue	NN
cord-018387-ci5wx26t	279	20	by	by	IN
cord-018387-ci5wx26t	279	21	phenotype	phenotype	NN
cord-018387-ci5wx26t	279	22	switching	switch	VBG
cord-018387-ci5wx26t	279	23	from	from	IN
cord-018387-ci5wx26t	279	24	pro	pro	JJ
cord-018387-ci5wx26t	279	25	-	-	JJ
cord-018387-ci5wx26t	279	26	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	279	27	M1-type	M1-type	NNS
cord-018387-ci5wx26t	279	28	to	to	IN
cord-018387-ci5wx26t	279	29	anti	anti	JJ
cord-018387-ci5wx26t	279	30	-	-	JJ
cord-018387-ci5wx26t	279	31	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	279	32	M2-type	M2-type	NNS
cord-018387-ci5wx26t	279	33	macrophages	macrophage	NNS
cord-018387-ci5wx26t	279	34	(	(	-LRB-
cord-018387-ci5wx26t	279	35	Fig	Fig	NNP
cord-018387-ci5wx26t	279	36	.	.	.
cord-018387-ci5wx26t	279	37	14.4	14.4	CD
cord-018387-ci5wx26t	279	38	)	)	-RRB-
cord-018387-ci5wx26t	279	39	.	.	.
cord-018387-ci5wx26t	280	1	In	in	IN
cord-018387-ci5wx26t	280	2	addition	addition	NN
cord-018387-ci5wx26t	280	3	,	,	,
cord-018387-ci5wx26t	280	4	a	a	DT
cord-018387-ci5wx26t	280	5	reduction	reduction	NN
cord-018387-ci5wx26t	280	6	in	in	IN
cord-018387-ci5wx26t	280	7	the	the	DT
cord-018387-ci5wx26t	280	8	numbers	number	NNS
cord-018387-ci5wx26t	280	9	of	of	IN
cord-018387-ci5wx26t	280	10	circulating	circulate	VBG
cord-018387-ci5wx26t	280	11	pro	pro	JJ
cord-018387-ci5wx26t	280	12	-	-	JJ
cord-018387-ci5wx26t	280	13	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	280	14	-	-	HYPH
cord-018387-ci5wx26t	280	15	type	type	NN
cord-018387-ci5wx26t	280	16	monocytes	monocyte	NNS
cord-018387-ci5wx26t	280	17	and	and	CC
cord-018387-ci5wx26t	280	18	an	an	DT
cord-018387-ci5wx26t	280	19	increase	increase	NN
cord-018387-ci5wx26t	280	20	in	in	IN
cord-018387-ci5wx26t	280	21	the	the	DT
cord-018387-ci5wx26t	280	22	numbers	number	NNS
cord-018387-ci5wx26t	280	23	of	of	IN
cord-018387-ci5wx26t	280	24	Tregs	Tregs	NNP
cord-018387-ci5wx26t	280	25	were	be	VBD
cord-018387-ci5wx26t	280	26	found	find	VBN
cord-018387-ci5wx26t	280	27	in	in	IN
cord-018387-ci5wx26t	280	28	the	the	DT
cord-018387-ci5wx26t	280	29	peripheral	peripheral	JJ
cord-018387-ci5wx26t	280	30	blood	blood	NN
cord-018387-ci5wx26t	280	31	of	of	IN
cord-018387-ci5wx26t	280	32	individuals	individual	NNS
cord-018387-ci5wx26t	280	33	following	follow	VBG
cord-018387-ci5wx26t	280	34	physical	physical	JJ
cord-018387-ci5wx26t	280	35	activity	activity	NN
cord-018387-ci5wx26t	280	36	[	[	-LRB-
cord-018387-ci5wx26t	280	37	156	156	CD
cord-018387-ci5wx26t	280	38	,	,	,
cord-018387-ci5wx26t	280	39	157	157	CD
cord-018387-ci5wx26t	280	40	]	]	-RRB-
cord-018387-ci5wx26t	280	41	.	.	.
cord-018387-ci5wx26t	281	1	Recent	recent	JJ
cord-018387-ci5wx26t	281	2	evidence	evidence	NN
cord-018387-ci5wx26t	281	3	suggests	suggest	VBZ
cord-018387-ci5wx26t	281	4	that	that	IN
cord-018387-ci5wx26t	281	5	contracting	contracting	NN
cord-018387-ci5wx26t	281	6	muscles	muscle	NNS
cord-018387-ci5wx26t	281	7	release	release	VB
cord-018387-ci5wx26t	281	8	myokines	myokines	NNP
cord-018387-ci5wx26t	281	9	[	[	-LRB-
cord-018387-ci5wx26t	281	10	2	2	CD
cord-018387-ci5wx26t	281	11	,	,	,
cord-018387-ci5wx26t	281	12	[	[	-LRB-
cord-018387-ci5wx26t	281	13	158	158	CD
cord-018387-ci5wx26t	281	14	]	]	-RRB-
cord-018387-ci5wx26t	281	15	[	[	-LRB-
cord-018387-ci5wx26t	281	16	159	159	CD
cord-018387-ci5wx26t	281	17	]	]	-RRB-
cord-018387-ci5wx26t	281	18	[	[	-LRB-
cord-018387-ci5wx26t	281	19	160	160	CD
cord-018387-ci5wx26t	281	20	]	]	-RRB-
cord-018387-ci5wx26t	281	21	[	[	-LRB-
cord-018387-ci5wx26t	281	22	161	161	CD
cord-018387-ci5wx26t	281	23	]	]	-RRB-
cord-018387-ci5wx26t	281	24	[	[	-LRB-
cord-018387-ci5wx26t	281	25	162	162	CD
cord-018387-ci5wx26t	281	26	]	]	-RRB-
cord-018387-ci5wx26t	281	27	,	,	,
cord-018387-ci5wx26t	281	28	which	which	WDT
cord-018387-ci5wx26t	281	29	affect	affect	VBP
cord-018387-ci5wx26t	281	30	the	the	DT
cord-018387-ci5wx26t	281	31	synthesis	synthesis	NN
cord-018387-ci5wx26t	281	32	of	of	IN
cord-018387-ci5wx26t	281	33	BDNF	BDNF	NNP
cord-018387-ci5wx26t	281	34	in	in	IN
cord-018387-ci5wx26t	281	35	the	the	DT
cord-018387-ci5wx26t	281	36	dentate	dentate	NN
cord-018387-ci5wx26t	281	37	gyrus	gyrus	NN
cord-018387-ci5wx26t	281	38	of	of	IN
cord-018387-ci5wx26t	281	39	the	the	DT
cord-018387-ci5wx26t	281	40	hippocampus	hippocampus	NN
cord-018387-ci5wx26t	281	41	[	[	-LRB-
cord-018387-ci5wx26t	281	42	162	162	CD
cord-018387-ci5wx26t	281	43	]	]	-RRB-
cord-018387-ci5wx26t	281	44	.	.	.
cord-018387-ci5wx26t	282	1	Physical	physical	JJ
cord-018387-ci5wx26t	282	2	activity	activity	NN
cord-018387-ci5wx26t	282	3	may	may	MD
cord-018387-ci5wx26t	282	4	have	have	VB
cord-018387-ci5wx26t	282	5	a	a	DT
cord-018387-ci5wx26t	282	6	buffering	buffering	NN
cord-018387-ci5wx26t	282	7	role	role	NN
cord-018387-ci5wx26t	282	8	on	on	IN
cord-018387-ci5wx26t	282	9	the	the	DT
cord-018387-ci5wx26t	282	10	hormonal	hormonal	JJ
cord-018387-ci5wx26t	282	11	stress	stress	NN
cord-018387-ci5wx26t	282	12	-	-	HYPH
cord-018387-ci5wx26t	282	13	responsive	responsive	JJ
cord-018387-ci5wx26t	282	14	systems	system	NNS
cord-018387-ci5wx26t	282	15	(	(	-LRB-
cord-018387-ci5wx26t	282	16	Fig	Fig	NNP
cord-018387-ci5wx26t	282	17	.	.	.
cord-018387-ci5wx26t	282	18	14.4	14.4	CD
cord-018387-ci5wx26t	282	19	)	)	-RRB-
cord-018387-ci5wx26t	282	20	,	,	,
cord-018387-ci5wx26t	282	21	such	such	JJ
cord-018387-ci5wx26t	282	22	as	as	IN
cord-018387-ci5wx26t	282	23	the	the	DT
cord-018387-ci5wx26t	282	24	HPA	HPA	NNP
cord-018387-ci5wx26t	282	25	axis	axis	NN
cord-018387-ci5wx26t	282	26	and	and	CC
cord-018387-ci5wx26t	282	27	the	the	DT
cord-018387-ci5wx26t	282	28	sympathetic	sympathetic	JJ
cord-018387-ci5wx26t	282	29	nervous	nervous	JJ
cord-018387-ci5wx26t	282	30	system	system	NN
cord-018387-ci5wx26t	282	31	[	[	-LRB-
cord-018387-ci5wx26t	282	32	163	163	CD
cord-018387-ci5wx26t	282	33	]	]	-RRB-
cord-018387-ci5wx26t	282	34	,	,	,
cord-018387-ci5wx26t	282	35	thus	thus	RB
cord-018387-ci5wx26t	282	36	maintaining	maintain	VBG
cord-018387-ci5wx26t	282	37	immunoprotective	immunoprotective	JJ
cord-018387-ci5wx26t	282	38	and	and	CC
cord-018387-ci5wx26t	282	39	neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	282	40	functions	function	NNS
cord-018387-ci5wx26t	282	41	.	.	.
cord-018387-ci5wx26t	283	1	It	-PRON-	PRP
cord-018387-ci5wx26t	283	2	has	have	VBZ
cord-018387-ci5wx26t	283	3	been	be	VBN
cord-018387-ci5wx26t	283	4	also	also	RB
cord-018387-ci5wx26t	283	5	shown	show	VBN
cord-018387-ci5wx26t	283	6	that	that	IN
cord-018387-ci5wx26t	283	7	regular	regular	JJ
cord-018387-ci5wx26t	283	8	exercise	exercise	NN
cord-018387-ci5wx26t	283	9	is	be	VBZ
cord-018387-ci5wx26t	283	10	associated	associate	VBN
cord-018387-ci5wx26t	283	11	with	with	IN
cord-018387-ci5wx26t	283	12	an	an	DT
cord-018387-ci5wx26t	283	13	improved	improved	JJ
cord-018387-ci5wx26t	283	14	immune	immune	JJ
cord-018387-ci5wx26t	283	15	responsiveness	responsiveness	NN
cord-018387-ci5wx26t	283	16	to	to	IN
cord-018387-ci5wx26t	283	17	influenza	influenza	NN
cord-018387-ci5wx26t	283	18	vaccination	vaccination	NN
cord-018387-ci5wx26t	283	19	in	in	IN
cord-018387-ci5wx26t	283	20	older	old	JJR
cord-018387-ci5wx26t	283	21	adults	adult	NNS
cord-018387-ci5wx26t	283	22	.	.	.
cord-018387-ci5wx26t	284	1	The	the	DT
cord-018387-ci5wx26t	284	2	exercise	exercise	NN
cord-018387-ci5wx26t	284	3	-	-	HYPH
cord-018387-ci5wx26t	284	4	related	relate	VBN
cord-018387-ci5wx26t	284	5	increase	increase	NN
cord-018387-ci5wx26t	284	6	in	in	IN
cord-018387-ci5wx26t	284	7	the	the	DT
cord-018387-ci5wx26t	284	8	antibody	antibody	NN
cord-018387-ci5wx26t	284	9	titer	titer	NN
cord-018387-ci5wx26t	284	10	,	,	,
cord-018387-ci5wx26t	284	11	T	t	NN
cord-018387-ci5wx26t	284	12	-	-	HYPH
cord-018387-ci5wx26t	284	13	cell	cell	NN
cord-018387-ci5wx26t	284	14	function	function	NN
cord-018387-ci5wx26t	284	15	,	,	,
cord-018387-ci5wx26t	284	16	macrophage	macrophage	NN
cord-018387-ci5wx26t	284	17	response	response	NN
cord-018387-ci5wx26t	284	18	,	,	,
cord-018387-ci5wx26t	284	19	improvement	improvement	NN
cord-018387-ci5wx26t	284	20	of	of	IN
cord-018387-ci5wx26t	284	21	the	the	DT
cord-018387-ci5wx26t	284	22	Th1	th1	CD
cord-018387-ci5wx26t	284	23	/	/	SYM
cord-018387-ci5wx26t	284	24	Th2	th2	CD
cord-018387-ci5wx26t	284	25	cytokine	cytokine	NN
cord-018387-ci5wx26t	284	26	balance	balance	NN
cord-018387-ci5wx26t	284	27	,	,	,
cord-018387-ci5wx26t	284	28	the	the	DT
cord-018387-ci5wx26t	284	29	level	level	NN
cord-018387-ci5wx26t	284	30	of	of	IN
cord-018387-ci5wx26t	284	31	pro	pro	JJ
cord-018387-ci5wx26t	284	32	-	-	JJ
cord-018387-ci5wx26t	284	33	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	284	34	cytokines	cytokine	NNS
cord-018387-ci5wx26t	284	35	,	,	,
cord-018387-ci5wx26t	284	36	and	and	CC
cord-018387-ci5wx26t	284	37	changes	change	NNS
cord-018387-ci5wx26t	284	38	in	in	IN
cord-018387-ci5wx26t	284	39	naive/	naive/	CD
cord-018387-ci5wx26t	284	40	memory	memory	NN
cord-018387-ci5wx26t	284	41	cell	cell	NN
cord-018387-ci5wx26t	284	42	ratio	ratio	NN
cord-018387-ci5wx26t	284	43	have	have	VBP
cord-018387-ci5wx26t	284	44	also	also	RB
cord-018387-ci5wx26t	284	45	been	be	VBN
cord-018387-ci5wx26t	284	46	reported	report	VBN
cord-018387-ci5wx26t	284	47	[	[	-LRB-
cord-018387-ci5wx26t	284	48	164	164	CD
cord-018387-ci5wx26t	284	49	]	]	-RRB-
cord-018387-ci5wx26t	284	50	.	.	.
cord-018387-ci5wx26t	285	1	Taken	take	VBN
cord-018387-ci5wx26t	285	2	together	together	RB
cord-018387-ci5wx26t	285	3	,	,	,
cord-018387-ci5wx26t	285	4	one	one	PRP
cord-018387-ci5wx26t	285	5	might	may	MD
cord-018387-ci5wx26t	285	6	conclude	conclude	VB
cord-018387-ci5wx26t	285	7	that	that	IN
cord-018387-ci5wx26t	285	8	nutritional	nutritional	JJ
cord-018387-ci5wx26t	285	9	intervention	intervention	NN
cord-018387-ci5wx26t	285	10	in	in	IN
cord-018387-ci5wx26t	285	11	combination	combination	NN
cord-018387-ci5wx26t	285	12	with	with	IN
cord-018387-ci5wx26t	285	13	physical	physical	JJ
cord-018387-ci5wx26t	285	14	activity	activity	NN
cord-018387-ci5wx26t	285	15	activates	activate	VBZ
cord-018387-ci5wx26t	285	16	and/or	and/or	CC
cord-018387-ci5wx26t	285	17	modulates	modulate	VBZ
cord-018387-ci5wx26t	285	18	the	the	DT
cord-018387-ci5wx26t	285	19	release	release	NN
cord-018387-ci5wx26t	285	20	of	of	IN
cord-018387-ci5wx26t	285	21	hormones	hormone	NNS
cord-018387-ci5wx26t	285	22	,	,	,
cord-018387-ci5wx26t	285	23	myokines	myokine	NNS
cord-018387-ci5wx26t	285	24	,	,	,
cord-018387-ci5wx26t	285	25	and	and	CC
cord-018387-ci5wx26t	285	26	cytokines	cytokine	NNS
cord-018387-ci5wx26t	285	27	as	as	RB
cord-018387-ci5wx26t	285	28	well	well	RB
cord-018387-ci5wx26t	285	29	as	as	IN
cord-018387-ci5wx26t	285	30	modulate	modulate	VB
cord-018387-ci5wx26t	285	31	the	the	DT
cord-018387-ci5wx26t	285	32	expression	expression	NN
cord-018387-ci5wx26t	285	33	of	of	IN
cord-018387-ci5wx26t	285	34	various	various	JJ
cord-018387-ci5wx26t	285	35	immune	immune	JJ
cord-018387-ci5wx26t	285	36	-	-	HYPH
cord-018387-ci5wx26t	285	37	reactive	reactive	JJ
cord-018387-ci5wx26t	285	38	molecules	molecule	NNS
cord-018387-ci5wx26t	285	39	,	,	,
cord-018387-ci5wx26t	285	40	which	which	WDT
cord-018387-ci5wx26t	285	41	all	all	DT
cord-018387-ci5wx26t	285	42	contribute	contribute	VBP
cord-018387-ci5wx26t	285	43	to	to	IN
cord-018387-ci5wx26t	285	44	anti	anti	JJ
cord-018387-ci5wx26t	285	45	-	-	JJ
cord-018387-ci5wx26t	285	46	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	285	47	effects	effect	NNS
cord-018387-ci5wx26t	285	48	and	and	CC
cord-018387-ci5wx26t	285	49	the	the	DT
cord-018387-ci5wx26t	285	50	possible	possible	JJ
cord-018387-ci5wx26t	285	51	attenuation	attenuation	NN
cord-018387-ci5wx26t	285	52	of	of	IN
cord-018387-ci5wx26t	285	53	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	285	54	and	and	CC
cord-018387-ci5wx26t	285	55	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	285	56	.	.	.
cord-018387-ci5wx26t	286	1	Around	around	IN
cord-018387-ci5wx26t	286	2	the	the	DT
cord-018387-ci5wx26t	286	3	world	world	NN
cord-018387-ci5wx26t	286	4	,	,	,
cord-018387-ci5wx26t	286	5	especially	especially	RB
cord-018387-ci5wx26t	286	6	in	in	IN
cord-018387-ci5wx26t	286	7	many	many	JJ
cord-018387-ci5wx26t	286	8	European	european	JJ
cord-018387-ci5wx26t	286	9	countries	country	NNS
cord-018387-ci5wx26t	286	10	,	,	,
cord-018387-ci5wx26t	286	11	the	the	DT
cord-018387-ci5wx26t	286	12	older	old	JJR
cord-018387-ci5wx26t	286	13	segment	segment	NN
cord-018387-ci5wx26t	286	14	of	of	IN
cord-018387-ci5wx26t	286	15	the	the	DT
cord-018387-ci5wx26t	286	16	adult	adult	NN
cord-018387-ci5wx26t	286	17	population	population	NN
cord-018387-ci5wx26t	286	18	is	be	VBZ
cord-018387-ci5wx26t	286	19	growing	grow	VBG
cord-018387-ci5wx26t	286	20	in	in	IN
cord-018387-ci5wx26t	286	21	size	size	NN
cord-018387-ci5wx26t	286	22	and	and	CC
cord-018387-ci5wx26t	286	23	proportion	proportion	NN
cord-018387-ci5wx26t	286	24	[	[	-LRB-
cord-018387-ci5wx26t	286	25	165	165	CD
cord-018387-ci5wx26t	286	26	]	]	-RRB-
cord-018387-ci5wx26t	286	27	.	.	.
cord-018387-ci5wx26t	287	1	In	in	IN
cord-018387-ci5wx26t	287	2	dealing	deal	VBG
cord-018387-ci5wx26t	287	3	with	with	IN
cord-018387-ci5wx26t	287	4	this	this	DT
cord-018387-ci5wx26t	287	5	demographic	demographic	JJ
cord-018387-ci5wx26t	287	6	change	change	NN
cord-018387-ci5wx26t	287	7	,	,	,
cord-018387-ci5wx26t	287	8	what	what	WP
cord-018387-ci5wx26t	287	9	people	people	NNS
cord-018387-ci5wx26t	287	10	make	make	VBP
cord-018387-ci5wx26t	287	11	of	of	IN
cord-018387-ci5wx26t	287	12	the	the	DT
cord-018387-ci5wx26t	287	13	added	add	VBN
cord-018387-ci5wx26t	287	14	years	year	NNS
cord-018387-ci5wx26t	287	15	of	of	IN
cord-018387-ci5wx26t	287	16	their	-PRON-	PRP$
cord-018387-ci5wx26t	287	17	lives	life	NNS
cord-018387-ci5wx26t	287	18	will	will	MD
cord-018387-ci5wx26t	287	19	be	be	VB
cord-018387-ci5wx26t	287	20	the	the	DT
cord-018387-ci5wx26t	287	21	most	most	RBS
cord-018387-ci5wx26t	287	22	important	important	JJ
cord-018387-ci5wx26t	287	23	aspect	aspect	NN
cord-018387-ci5wx26t	287	24	but	but	CC
cord-018387-ci5wx26t	287	25	will	will	MD
cord-018387-ci5wx26t	287	26	only	only	RB
cord-018387-ci5wx26t	287	27	be	be	VB
cord-018387-ci5wx26t	287	28	advantageous	advantageous	JJ
cord-018387-ci5wx26t	287	29	to	to	IN
cord-018387-ci5wx26t	287	30	the	the	DT
cord-018387-ci5wx26t	287	31	individual	individual	NN
cord-018387-ci5wx26t	287	32	and	and	CC
cord-018387-ci5wx26t	287	33	to	to	IN
cord-018387-ci5wx26t	287	34	society	society	NN
cord-018387-ci5wx26t	287	35	at	at	IN
cord-018387-ci5wx26t	287	36	large	large	JJ
cord-018387-ci5wx26t	287	37	if	if	IN
cord-018387-ci5wx26t	287	38	people	people	NNS
cord-018387-ci5wx26t	287	39	can	can	MD
cord-018387-ci5wx26t	287	40	remain	remain	VB
cord-018387-ci5wx26t	287	41	active	active	JJ
cord-018387-ci5wx26t	287	42	participants	participant	NNS
cord-018387-ci5wx26t	287	43	in	in	IN
cord-018387-ci5wx26t	287	44	daily	daily	JJ
cord-018387-ci5wx26t	287	45	life	life	NN
cord-018387-ci5wx26t	287	46	and	and	CC
cord-018387-ci5wx26t	287	47	work	work	NN
cord-018387-ci5wx26t	287	48	[	[	-LRB-
cord-018387-ci5wx26t	287	49	65	65	CD
cord-018387-ci5wx26t	287	50	]	]	-RRB-
cord-018387-ci5wx26t	287	51	.	.	.
cord-018387-ci5wx26t	288	1	Maintaining	maintain	VBG
cord-018387-ci5wx26t	288	2	immunological	immunological	JJ
cord-018387-ci5wx26t	288	3	and	and	CC
cord-018387-ci5wx26t	288	4	cognitive	cognitive	JJ
cord-018387-ci5wx26t	288	5	functions	function	NNS
cord-018387-ci5wx26t	288	6	will	will	MD
cord-018387-ci5wx26t	288	7	be	be	VB
cord-018387-ci5wx26t	288	8	paramount	paramount	JJ
cord-018387-ci5wx26t	288	9	,	,	,
cord-018387-ci5wx26t	288	10	but	but	CC
cord-018387-ci5wx26t	288	11	their	-PRON-	PRP$
cord-018387-ci5wx26t	288	12	performances	performance	NNS
cord-018387-ci5wx26t	288	13	are	be	VBP
cord-018387-ci5wx26t	288	14	known	know	VBN
cord-018387-ci5wx26t	288	15	to	to	TO
cord-018387-ci5wx26t	288	16	decrease	decrease	VB
cord-018387-ci5wx26t	288	17	with	with	IN
cord-018387-ci5wx26t	288	18	increasing	increase	VBG
cord-018387-ci5wx26t	288	19	age	age	NN
cord-018387-ci5wx26t	288	20	,	,	,
cord-018387-ci5wx26t	288	21	even	even	RB
cord-018387-ci5wx26t	288	22	in	in	IN
cord-018387-ci5wx26t	288	23	overtly	overtly	RB
cord-018387-ci5wx26t	288	24	healthy	healthy	JJ
cord-018387-ci5wx26t	288	25	individuals	individual	NNS
cord-018387-ci5wx26t	288	26	.	.	.
cord-018387-ci5wx26t	289	1	Preventing	prevent	VBG
cord-018387-ci5wx26t	289	2	and/or	and/or	CC
cord-018387-ci5wx26t	289	3	attenuating	attenuate	VBG
cord-018387-ci5wx26t	289	4	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	289	5	and	and	CC
cord-018387-ci5wx26t	289	6	inflammation	inflammation	NN
cord-018387-ci5wx26t	289	7	and	and	CC
cord-018387-ci5wx26t	289	8	delaying	delay	VBG
cord-018387-ci5wx26t	289	9	cognitive	cognitive	JJ
cord-018387-ci5wx26t	289	10	decline	decline	NN
cord-018387-ci5wx26t	289	11	are	be	VBP
cord-018387-ci5wx26t	289	12	probably	probably	RB
cord-018387-ci5wx26t	289	13	the	the	DT
cord-018387-ci5wx26t	289	14	most	most	RBS
cord-018387-ci5wx26t	289	15	effective	effective	JJ
cord-018387-ci5wx26t	289	16	measures	measure	NNS
cord-018387-ci5wx26t	289	17	for	for	IN
cord-018387-ci5wx26t	289	18	postponing	postpone	VBG
cord-018387-ci5wx26t	289	19	the	the	DT
cord-018387-ci5wx26t	289	20	point	point	NN
cord-018387-ci5wx26t	289	21	of	of	IN
cord-018387-ci5wx26t	289	22	time	time	NN
cord-018387-ci5wx26t	289	23	at	at	IN
cord-018387-ci5wx26t	289	24	which	which	WDT
cord-018387-ci5wx26t	289	25	individuals	individual	NNS
cord-018387-ci5wx26t	289	26	are	be	VBP
cord-018387-ci5wx26t	289	27	no	no	RB
cord-018387-ci5wx26t	289	28	longer	longer	RB
cord-018387-ci5wx26t	289	29	able	able	JJ
cord-018387-ci5wx26t	289	30	to	to	TO
cord-018387-ci5wx26t	289	31	lead	lead	VB
cord-018387-ci5wx26t	289	32	an	an	DT
cord-018387-ci5wx26t	289	33	independent	independent	JJ
cord-018387-ci5wx26t	289	34	life	life	NN
cord-018387-ci5wx26t	289	35	[	[	-LRB-
cord-018387-ci5wx26t	289	36	65	65	CD
cord-018387-ci5wx26t	289	37	]	]	-RRB-
cord-018387-ci5wx26t	289	38	.	.	.
cord-018387-ci5wx26t	290	1	Effective	effective	JJ
cord-018387-ci5wx26t	290	2	pharmacological	pharmacological	JJ
cord-018387-ci5wx26t	290	3	treatments	treatment	NNS
cord-018387-ci5wx26t	290	4	,	,	,
cord-018387-ci5wx26t	290	5	especially	especially	RB
cord-018387-ci5wx26t	290	6	for	for	IN
cord-018387-ci5wx26t	290	7	cognitive	cognitive	JJ
cord-018387-ci5wx26t	290	8	but	but	CC
cord-018387-ci5wx26t	290	9	also	also	RB
cord-018387-ci5wx26t	290	10	for	for	IN
cord-018387-ci5wx26t	290	11	the	the	DT
cord-018387-ci5wx26t	290	12	immune	immune	JJ
cord-018387-ci5wx26t	290	13	decline	decline	NN
cord-018387-ci5wx26t	290	14	,	,	,
cord-018387-ci5wx26t	290	15	remain	remain	VBP
cord-018387-ci5wx26t	290	16	unavailable	unavailable	JJ
cord-018387-ci5wx26t	290	17	.	.	.
cord-018387-ci5wx26t	291	1	Therefore	therefore	RB
cord-018387-ci5wx26t	291	2	,	,	,
cord-018387-ci5wx26t	291	3	we	-PRON-	PRP
cord-018387-ci5wx26t	291	4	will	will	MD
cord-018387-ci5wx26t	291	5	need	need	VB
cord-018387-ci5wx26t	291	6	a	a	DT
cord-018387-ci5wx26t	291	7	more	more	RBR
cord-018387-ci5wx26t	291	8	holistic	holistic	JJ
cord-018387-ci5wx26t	291	9	view	view	NN
cord-018387-ci5wx26t	291	10	of	of	IN
cord-018387-ci5wx26t	291	11	the	the	DT
cord-018387-ci5wx26t	291	12	aging	aging	NN
cord-018387-ci5wx26t	291	13	process	process	NN
cord-018387-ci5wx26t	291	14	,	,	,
cord-018387-ci5wx26t	291	15	where	where	WRB
cord-018387-ci5wx26t	291	16	the	the	DT
cord-018387-ci5wx26t	291	17	dynamics	dynamic	NNS
cord-018387-ci5wx26t	291	18	of	of	IN
cord-018387-ci5wx26t	291	19	the	the	DT
cord-018387-ci5wx26t	291	20	interaction	interaction	NN
cord-018387-ci5wx26t	291	21	between	between	IN
cord-018387-ci5wx26t	291	22	environment	environment	NN
cord-018387-ci5wx26t	291	23	,	,	,
cord-018387-ci5wx26t	291	24	intestinal	intestinal	JJ
cord-018387-ci5wx26t	291	25	microbiota	microbiota	NN
cord-018387-ci5wx26t	291	26	,	,	,
cord-018387-ci5wx26t	291	27	and	and	CC
cord-018387-ci5wx26t	291	28	host	host	NN
cord-018387-ci5wx26t	291	29	must	must	MD
cord-018387-ci5wx26t	291	30	be	be	VB
cord-018387-ci5wx26t	291	31	taken	take	VBN
cord-018387-ci5wx26t	291	32	into	into	IN
cord-018387-ci5wx26t	291	33	consideration	consideration	NN
cord-018387-ci5wx26t	291	34	.	.	.
cord-018387-ci5wx26t	292	1	We	-PRON-	PRP
cord-018387-ci5wx26t	292	2	should	should	MD
cord-018387-ci5wx26t	292	3	also	also	RB
cord-018387-ci5wx26t	292	4	take	take	VB
cord-018387-ci5wx26t	292	5	into	into	IN
cord-018387-ci5wx26t	292	6	account	account	NN
cord-018387-ci5wx26t	292	7	the	the	DT
cord-018387-ci5wx26t	292	8	age	age	NN
cord-018387-ci5wx26t	292	9	-	-	HYPH
cord-018387-ci5wx26t	292	10	associated	associate	VBN
cord-018387-ci5wx26t	292	11	physiological	physiological	JJ
cord-018387-ci5wx26t	292	12	changes	change	NNS
cord-018387-ci5wx26t	292	13	in	in	IN
cord-018387-ci5wx26t	292	14	the	the	DT
cord-018387-ci5wx26t	292	15	gastrointestinal	gastrointestinal	JJ
cord-018387-ci5wx26t	292	16	tract	tract	NN
cord-018387-ci5wx26t	292	17	as	as	RB
cord-018387-ci5wx26t	292	18	well	well	RB
cord-018387-ci5wx26t	292	19	as	as	IN
cord-018387-ci5wx26t	292	20	age	age	NN
cord-018387-ci5wx26t	292	21	-	-	HYPH
cord-018387-ci5wx26t	292	22	related	relate	VBN
cord-018387-ci5wx26t	292	23	modifications	modification	NNS
cord-018387-ci5wx26t	292	24	in	in	IN
cord-018387-ci5wx26t	292	25	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	292	26	,	,	,
cord-018387-ci5wx26t	292	27	nutritional	nutritional	JJ
cord-018387-ci5wx26t	292	28	behavior	behavior	NN
cord-018387-ci5wx26t	292	29	,	,	,
cord-018387-ci5wx26t	292	30	and	and	CC
cord-018387-ci5wx26t	292	31	impaired	impaired	JJ
cord-018387-ci5wx26t	292	32	functionality	functionality	NN
cord-018387-ci5wx26t	292	33	in	in	IN
cord-018387-ci5wx26t	292	34	the	the	DT
cord-018387-ci5wx26t	292	35	immune	immune	JJ
cord-018387-ci5wx26t	292	36	system	system	NN
cord-018387-ci5wx26t	292	37	of	of	IN
cord-018387-ci5wx26t	292	38	the	the	DT
cord-018387-ci5wx26t	292	39	elderly	elderly	JJ
cord-018387-ci5wx26t	292	40	population	population	NN
cord-018387-ci5wx26t	292	41	[	[	-LRB-
cord-018387-ci5wx26t	292	42	2	2	CD
cord-018387-ci5wx26t	292	43	,	,	,
cord-018387-ci5wx26t	292	44	65	65	CD
cord-018387-ci5wx26t	292	45	]	]	-RRB-
cord-018387-ci5wx26t	292	46	.	.	.
cord-018387-ci5wx26t	293	1	Some	some	DT
cord-018387-ci5wx26t	293	2	modifiable	modifiable	JJ
cord-018387-ci5wx26t	293	3	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	293	4	factors	factor	NNS
cord-018387-ci5wx26t	293	5	,	,	,
cord-018387-ci5wx26t	293	6	such	such	JJ
cord-018387-ci5wx26t	293	7	as	as	IN
cord-018387-ci5wx26t	293	8	poor	poor	JJ
cord-018387-ci5wx26t	293	9	diet	diet	NN
cord-018387-ci5wx26t	293	10	and	and	CC
cord-018387-ci5wx26t	293	11	physical	physical	JJ
cord-018387-ci5wx26t	293	12	and	and	CC
cord-018387-ci5wx26t	293	13	cognitive	cognitive	JJ
cord-018387-ci5wx26t	293	14	inactivity	inactivity	NN
cord-018387-ci5wx26t	293	15	,	,	,
cord-018387-ci5wx26t	293	16	have	have	VBP
cord-018387-ci5wx26t	293	17	been	be	VBN
cord-018387-ci5wx26t	293	18	identified	identify	VBN
cord-018387-ci5wx26t	293	19	as	as	IN
cord-018387-ci5wx26t	293	20	being	be	VBG
cord-018387-ci5wx26t	293	21	associated	associate	VBN
cord-018387-ci5wx26t	293	22	with	with	IN
cord-018387-ci5wx26t	293	23	an	an	DT
cord-018387-ci5wx26t	293	24	increased	increase	VBN
cord-018387-ci5wx26t	293	25	risk	risk	NN
cord-018387-ci5wx26t	293	26	of	of	IN
cord-018387-ci5wx26t	293	27	cognitive	cognitive	JJ
cord-018387-ci5wx26t	293	28	and	and	CC
cord-018387-ci5wx26t	293	29	immune	immune	JJ
cord-018387-ci5wx26t	293	30	decline	decline	NN
cord-018387-ci5wx26t	293	31	[	[	-LRB-
cord-018387-ci5wx26t	293	32	166	166	CD
cord-018387-ci5wx26t	293	33	]	]	-RRB-
cord-018387-ci5wx26t	293	34	.	.	.
cord-018387-ci5wx26t	294	1	Encouragingly	encouragingly	RB
cord-018387-ci5wx26t	294	2	,	,	,
cord-018387-ci5wx26t	294	3	exercise	exercise	NN
cord-018387-ci5wx26t	294	4	can	can	MD
cord-018387-ci5wx26t	294	5	have	have	VB
cord-018387-ci5wx26t	294	6	a	a	DT
cord-018387-ci5wx26t	294	7	protective	protective	JJ
cord-018387-ci5wx26t	294	8	effect	effect	NN
cord-018387-ci5wx26t	294	9	,	,	,
cord-018387-ci5wx26t	294	10	even	even	RB
cord-018387-ci5wx26t	294	11	if	if	IN
cord-018387-ci5wx26t	294	12	initiated	initiate	VBN
cord-018387-ci5wx26t	294	13	in	in	IN
cord-018387-ci5wx26t	294	14	advanced	advanced	JJ
cord-018387-ci5wx26t	294	15	old	old	JJ
cord-018387-ci5wx26t	294	16	age	age	NN
cord-018387-ci5wx26t	294	17	[	[	-LRB-
cord-018387-ci5wx26t	294	18	2	2	CD
cord-018387-ci5wx26t	294	19	,	,	,
cord-018387-ci5wx26t	294	20	65	65	CD
cord-018387-ci5wx26t	294	21	,	,	,
cord-018387-ci5wx26t	294	22	167	167	CD
cord-018387-ci5wx26t	294	23	]	]	-RRB-
cord-018387-ci5wx26t	294	24	.	.	.
cord-018387-ci5wx26t	295	1	The	the	DT
cord-018387-ci5wx26t	295	2	intake	intake	NN
cord-018387-ci5wx26t	295	3	of	of	IN
cord-018387-ci5wx26t	295	4	antioxidant	antioxidant	JJ
cord-018387-ci5wx26t	295	5	nutrients	nutrient	NNS
cord-018387-ci5wx26t	295	6	reduces	reduce	VBZ
cord-018387-ci5wx26t	295	7	both	both	DT
cord-018387-ci5wx26t	295	8	systemic	systemic	JJ
cord-018387-ci5wx26t	295	9	inflammation	inflammation	NN
cord-018387-ci5wx26t	295	10	and	and	CC
cord-018387-ci5wx26t	295	11	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	295	12	during	during	IN
cord-018387-ci5wx26t	295	13	aging	age	VBG
cord-018387-ci5wx26t	295	14	[	[	-LRB-
cord-018387-ci5wx26t	295	15	168	168	CD
cord-018387-ci5wx26t	295	16	]	]	-RRB-
cord-018387-ci5wx26t	295	17	.	.	.
cord-018387-ci5wx26t	296	1	Due	due	IN
cord-018387-ci5wx26t	296	2	to	to	IN
cord-018387-ci5wx26t	296	3	the	the	DT
cord-018387-ci5wx26t	296	4	fact	fact	NN
cord-018387-ci5wx26t	296	5	that	that	IN
cord-018387-ci5wx26t	296	6	diet	diet	NN
cord-018387-ci5wx26t	296	7	component	component	NN
cord-018387-ci5wx26t	296	8	targets	target	NNS
cord-018387-ci5wx26t	296	9	are	be	VBP
cord-018387-ci5wx26t	296	10	different	different	JJ
cord-018387-ci5wx26t	296	11	,	,	,
cord-018387-ci5wx26t	296	12	combining	combine	VBG
cord-018387-ci5wx26t	296	13	different	different	JJ
cord-018387-ci5wx26t	296	14	nutrients	nutrient	NNS
cord-018387-ci5wx26t	296	15	acting	act	VBG
cord-018387-ci5wx26t	296	16	on	on	IN
cord-018387-ci5wx26t	296	17	convergent	convergent	JJ
cord-018387-ci5wx26t	296	18	antiinflammatory	antiinflammatory	JJ
cord-018387-ci5wx26t	296	19	pathways	pathway	NNS
cord-018387-ci5wx26t	296	20	may	may	MD
cord-018387-ci5wx26t	296	21	result	result	VB
cord-018387-ci5wx26t	296	22	in	in	IN
cord-018387-ci5wx26t	296	23	an	an	DT
cord-018387-ci5wx26t	296	24	increased	increase	VBN
cord-018387-ci5wx26t	296	25	anti	anti	JJ
cord-018387-ci5wx26t	296	26	-	-	JJ
cord-018387-ci5wx26t	296	27	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	296	28	efficacy	efficacy	NN
cord-018387-ci5wx26t	296	29	[	[	-LRB-
cord-018387-ci5wx26t	296	30	144	144	CD
cord-018387-ci5wx26t	296	31	,	,	,
cord-018387-ci5wx26t	296	32	169	169	CD
cord-018387-ci5wx26t	296	33	,	,	,
cord-018387-ci5wx26t	296	34	170	170	CD
cord-018387-ci5wx26t	296	35	]	]	-RRB-
cord-018387-ci5wx26t	296	36	.	.	.
cord-018387-ci5wx26t	297	1	In	in	IN
cord-018387-ci5wx26t	297	2	this	this	DT
cord-018387-ci5wx26t	297	3	chapter	chapter	NN
cord-018387-ci5wx26t	297	4	,	,	,
cord-018387-ci5wx26t	297	5	we	-PRON-	PRP
cord-018387-ci5wx26t	297	6	have	have	VBP
cord-018387-ci5wx26t	297	7	described	describe	VBN
cord-018387-ci5wx26t	297	8	the	the	DT
cord-018387-ci5wx26t	297	9	potential	potential	JJ
cord-018387-ci5wx26t	297	10	basic	basic	JJ
cord-018387-ci5wx26t	297	11	processes	process	NNS
cord-018387-ci5wx26t	297	12	underlying	underlie	VBG
cord-018387-ci5wx26t	297	13	age	age	NN
cord-018387-ci5wx26t	297	14	-	-	HYPH
cord-018387-ci5wx26t	297	15	related	relate	VBN
cord-018387-ci5wx26t	297	16	decline	decline	NN
cord-018387-ci5wx26t	297	17	,	,	,
cord-018387-ci5wx26t	297	18	namely	namely	RB
cord-018387-ci5wx26t	297	19	,	,	,
cord-018387-ci5wx26t	297	20	immunosenescence	immunosenescence	NNP
cord-018387-ci5wx26t	297	21	and	and	CC
cord-018387-ci5wx26t	297	22	a	a	DT
cord-018387-ci5wx26t	297	23	progressive	progressive	JJ
cord-018387-ci5wx26t	297	24	increase	increase	NN
cord-018387-ci5wx26t	297	25	in	in	IN
cord-018387-ci5wx26t	297	26	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	297	27	characterized	characterize	VBN
cord-018387-ci5wx26t	297	28	by	by	IN
cord-018387-ci5wx26t	297	29	an	an	DT
cord-018387-ci5wx26t	297	30	increased	increase	VBN
cord-018387-ci5wx26t	297	31	glial	glial	JJ
cord-018387-ci5wx26t	297	32	activation	activation	NN
cord-018387-ci5wx26t	297	33	,	,	,
cord-018387-ci5wx26t	297	34	elevated	elevate	VBD
cord-018387-ci5wx26t	297	35	steady	steady	JJ
cord-018387-ci5wx26t	297	36	-	-	HYPH
cord-018387-ci5wx26t	297	37	state	state	NN
cord-018387-ci5wx26t	297	38	levels	level	NNS
cord-018387-ci5wx26t	297	39	of	of	IN
cord-018387-ci5wx26t	297	40	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	297	41	cytokines	cytokine	NNS
cord-018387-ci5wx26t	297	42	,	,	,
cord-018387-ci5wx26t	297	43	and	and	CC
cord-018387-ci5wx26t	297	44	a	a	DT
cord-018387-ci5wx26t	297	45	decreased	decreased	JJ
cord-018387-ci5wx26t	297	46	production	production	NN
cord-018387-ci5wx26t	297	47	of	of	IN
cord-018387-ci5wx26t	297	48	neurotrophic	neurotrophic	NN
cord-018387-ci5wx26t	297	49	molecules	molecule	NNS
cord-018387-ci5wx26t	297	50	as	as	RB
cord-018387-ci5wx26t	297	51	well	well	RB
cord-018387-ci5wx26t	297	52	as	as	IN
cord-018387-ci5wx26t	297	53	potential	potential	JJ
cord-018387-ci5wx26t	297	54	positive	positive	JJ
cord-018387-ci5wx26t	297	55	effects	effect	NNS
cord-018387-ci5wx26t	297	56	of	of	IN
cord-018387-ci5wx26t	297	57	nutrition	nutrition	NN
cord-018387-ci5wx26t	297	58	and	and	CC
cord-018387-ci5wx26t	297	59	physical	physical	JJ
cord-018387-ci5wx26t	297	60	exercise	exercise	NN
cord-018387-ci5wx26t	297	61	.	.	.
cord-018387-ci5wx26t	298	1	It	-PRON-	PRP
cord-018387-ci5wx26t	298	2	is	be	VBZ
cord-018387-ci5wx26t	298	3	our	-PRON-	PRP$
cord-018387-ci5wx26t	298	4	hypothesis	hypothesis	NN
cord-018387-ci5wx26t	298	5	,	,	,
cord-018387-ci5wx26t	298	6	as	as	IN
cord-018387-ci5wx26t	298	7	partly	partly	RB
cord-018387-ci5wx26t	298	8	summarized	summarize	VBN
cord-018387-ci5wx26t	298	9	here	here	RB
cord-018387-ci5wx26t	298	10	,	,	,
cord-018387-ci5wx26t	298	11	that	that	IN
cord-018387-ci5wx26t	298	12	a	a	DT
cord-018387-ci5wx26t	298	13	judicious	judicious	JJ
cord-018387-ci5wx26t	298	14	combination	combination	NN
cord-018387-ci5wx26t	298	15	of	of	IN
cord-018387-ci5wx26t	298	16	dietary	dietary	JJ
cord-018387-ci5wx26t	298	17	interventions	intervention	NNS
cord-018387-ci5wx26t	298	18	and	and	CC
cord-018387-ci5wx26t	298	19	exercise	exercise	NN
cord-018387-ci5wx26t	298	20	,	,	,
cord-018387-ci5wx26t	298	21	cognitive	cognitive	JJ
cord-018387-ci5wx26t	298	22	training	training	NN
cord-018387-ci5wx26t	298	23	,	,	,
cord-018387-ci5wx26t	298	24	and	and	CC
cord-018387-ci5wx26t	298	25	a	a	DT
cord-018387-ci5wx26t	298	26	pharmacological	pharmacological	JJ
cord-018387-ci5wx26t	298	27	manipulation	manipulation	NN
cord-018387-ci5wx26t	298	28	of	of	IN
cord-018387-ci5wx26t	298	29	immunosenescence	immunosenescence	NN
cord-018387-ci5wx26t	298	30	and	and	CC
cord-018387-ci5wx26t	298	31	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	298	32	processes	process	NNS
cord-018387-ci5wx26t	298	33	will	will	MD
cord-018387-ci5wx26t	298	34	eventually	eventually	RB
cord-018387-ci5wx26t	298	35	deliver	deliver	VB
cord-018387-ci5wx26t	298	36	an	an	DT
cord-018387-ci5wx26t	298	37	optimal	optimal	JJ
cord-018387-ci5wx26t	298	38	individualized	individualized	JJ
cord-018387-ci5wx26t	298	39	regime	regime	NN
cord-018387-ci5wx26t	298	40	for	for	IN
cord-018387-ci5wx26t	298	41	the	the	DT
cord-018387-ci5wx26t	298	42	maintenance	maintenance	NN
cord-018387-ci5wx26t	298	43	of	of	IN
cord-018387-ci5wx26t	298	44	the	the	DT
cord-018387-ci5wx26t	298	45	best	good	JJS
cord-018387-ci5wx26t	298	46	possible	possible	JJ
cord-018387-ci5wx26t	298	47	immune	immune	JJ
cord-018387-ci5wx26t	298	48	and	and	CC
cord-018387-ci5wx26t	298	49	cognitive	cognitive	JJ
cord-018387-ci5wx26t	298	50	functions	function	NNS
cord-018387-ci5wx26t	298	51	over	over	IN
cord-018387-ci5wx26t	298	52	the	the	DT
cord-018387-ci5wx26t	298	53	lifespan	lifespan	NN
cord-018387-ci5wx26t	298	54	of	of	IN
cord-018387-ci5wx26t	298	55	every	every	DT
cord-018387-ci5wx26t	298	56	individual	individual	NN
cord-018387-ci5wx26t	298	57	.	.	.
cord-018387-ci5wx26t	299	1	The	the	DT
cord-018387-ci5wx26t	299	2	role	role	NN
cord-018387-ci5wx26t	299	3	of	of	IN
cord-018387-ci5wx26t	299	4	nutrition	nutrition	NN
cord-018387-ci5wx26t	299	5	in	in	IN
cord-018387-ci5wx26t	299	6	enhancing	enhance	VBG
cord-018387-ci5wx26t	299	7	immunity	immunity	NN
cord-018387-ci5wx26t	299	8	in	in	IN
cord-018387-ci5wx26t	299	9	aging	age	VBG
cord-018387-ci5wx26t	299	10	Aging	aging	NN
cord-018387-ci5wx26t	299	11	and	and	CC
cord-018387-ci5wx26t	299	12	immunity	immunity	NN
cord-018387-ci5wx26t	300	1	-impact	-impact	:
cord-018387-ci5wx26t	300	2	of	of	IN
cord-018387-ci5wx26t	300	3	behavioral	behavioral	JJ
cord-018387-ci5wx26t	300	4	intervention	intervention	NN
cord-018387-ci5wx26t	300	5	Probiotics	probiotic	NNS
cord-018387-ci5wx26t	300	6	and	and	CC
cord-018387-ci5wx26t	300	7	prebiotics	prebiotic	NNS
cord-018387-ci5wx26t	300	8	and	and	CC
cord-018387-ci5wx26t	300	9	health	health	NN
cord-018387-ci5wx26t	300	10	in	in	IN
cord-018387-ci5wx26t	300	11	ageing	age	VBG
cord-018387-ci5wx26t	300	12	populations	population	NNS
cord-018387-ci5wx26t	301	1	The	the	DT
cord-018387-ci5wx26t	301	2	immune	immune	JJ
cord-018387-ci5wx26t	301	3	system	system	NN
cord-018387-ci5wx26t	301	4	:	:	:
cord-018387-ci5wx26t	301	5	a	a	DT
cord-018387-ci5wx26t	301	6	target	target	NN
cord-018387-ci5wx26t	301	7	for	for	IN
cord-018387-ci5wx26t	301	8	functional	functional	JJ
cord-018387-ci5wx26t	301	9	foods	food	NNS
cord-018387-ci5wx26t	301	10	?	?	.
cord-018387-ci5wx26t	302	1	Zinc	zinc	NN
cord-018387-ci5wx26t	302	2	and	and	CC
cord-018387-ci5wx26t	302	3	human	human	JJ
cord-018387-ci5wx26t	302	4	health	health	NN
cord-018387-ci5wx26t	302	5	:	:	:
cord-018387-ci5wx26t	302	6	an	an	DT
cord-018387-ci5wx26t	302	7	update	update	NN
cord-018387-ci5wx26t	302	8	Metallothioneins/	Metallothioneins/	NNP
cord-018387-ci5wx26t	302	9	PARP-1	PARP-1	NNP
cord-018387-ci5wx26t	302	10	/	/	SYM
cord-018387-ci5wx26t	302	11	IL-6	IL-6	NNP
cord-018387-ci5wx26t	302	12	interplay	interplay	NN
cord-018387-ci5wx26t	302	13	on	on	IN
cord-018387-ci5wx26t	302	14	natural	natural	JJ
cord-018387-ci5wx26t	302	15	killer	killer	NN
cord-018387-ci5wx26t	302	16	cell	cell	NN
cord-018387-ci5wx26t	302	17	activity	activity	NN
cord-018387-ci5wx26t	302	18	in	in	IN
cord-018387-ci5wx26t	302	19	elderly	elderly	JJ
cord-018387-ci5wx26t	302	20	:	:	:
cord-018387-ci5wx26t	302	21	parallelism	parallelism	NN
cord-018387-ci5wx26t	302	22	with	with	IN
cord-018387-ci5wx26t	302	23	nonagenarians	nonagenarian	NNS
cord-018387-ci5wx26t	302	24	and	and	CC
cord-018387-ci5wx26t	302	25	old	old	JJ
cord-018387-ci5wx26t	302	26	infected	infected	JJ
cord-018387-ci5wx26t	302	27	humans	human	NNS
cord-018387-ci5wx26t	302	28	.	.	.
cord-018387-ci5wx26t	303	1	Effect	effect	NN
cord-018387-ci5wx26t	303	2	of	of	IN
cord-018387-ci5wx26t	303	3	zinc	zinc	NN
cord-018387-ci5wx26t	303	4	supply	supply	NN
cord-018387-ci5wx26t	303	5	Zinc	Zinc	NNP
cord-018387-ci5wx26t	303	6	improves	improve	VBZ
cord-018387-ci5wx26t	303	7	the	the	DT
cord-018387-ci5wx26t	303	8	development	development	NN
cord-018387-ci5wx26t	303	9	of	of	IN
cord-018387-ci5wx26t	303	10	human	human	JJ
cord-018387-ci5wx26t	303	11	CD34	CD34	NNP
cord-018387-ci5wx26t	303	12	+	+	CC
cord-018387-ci5wx26t	303	13	cell	cell	NN
cord-018387-ci5wx26t	303	14	progenitors	progenitor	NNS
cord-018387-ci5wx26t	303	15	towards	towards	IN
cord-018387-ci5wx26t	303	16	NK	NK	NNP
cord-018387-ci5wx26t	303	17	cells	cell	NNS
cord-018387-ci5wx26t	303	18	and	and	CC
cord-018387-ci5wx26t	303	19	increases	increase	VBZ
cord-018387-ci5wx26t	303	20	the	the	DT
cord-018387-ci5wx26t	303	21	expression	expression	NN
cord-018387-ci5wx26t	303	22	of	of	IN
cord-018387-ci5wx26t	303	23	GATA-3	GATA-3	NNP
cord-018387-ci5wx26t	303	24	transcription	transcription	NN
cord-018387-ci5wx26t	303	25	factor	factor	NN
cord-018387-ci5wx26t	303	26	in	in	IN
cord-018387-ci5wx26t	303	27	young	young	JJ
cord-018387-ci5wx26t	303	28	and	and	CC
cord-018387-ci5wx26t	303	29	old	old	JJ
cord-018387-ci5wx26t	303	30	ages	age	NNS
cord-018387-ci5wx26t	303	31	Anti	anti	JJ
cord-018387-ci5wx26t	303	32	-	-	JJ
cord-018387-ci5wx26t	303	33	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	303	34	nutrition	nutrition	NN
cord-018387-ci5wx26t	303	35	as	as	IN
cord-018387-ci5wx26t	303	36	a	a	DT
cord-018387-ci5wx26t	303	37	pharmacological	pharmacological	JJ
cord-018387-ci5wx26t	303	38	approach	approach	NN
cord-018387-ci5wx26t	303	39	to	to	TO
cord-018387-ci5wx26t	303	40	treat	treat	VB
cord-018387-ci5wx26t	303	41	obesity	obesity	NN
cord-018387-ci5wx26t	303	42	Adipokines	Adipokines	NNPS
cord-018387-ci5wx26t	303	43	in	in	IN
cord-018387-ci5wx26t	303	44	inflammation	inflammation	NN
cord-018387-ci5wx26t	303	45	and	and	CC
cord-018387-ci5wx26t	303	46	metabolic	metabolic	JJ
cord-018387-ci5wx26t	303	47	disease	disease	NN
cord-018387-ci5wx26t	304	1	The	the	DT
cord-018387-ci5wx26t	304	2	anti	anti	JJ
cord-018387-ci5wx26t	304	3	-	-	JJ
cord-018387-ci5wx26t	304	4	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	304	5	effects	effect	NNS
cord-018387-ci5wx26t	304	6	of	of	IN
cord-018387-ci5wx26t	304	7	exercise	exercise	NN
cord-018387-ci5wx26t	304	8	:	:	:
cord-018387-ci5wx26t	304	9	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	304	10	and	and	CC
cord-018387-ci5wx26t	304	11	implications	implication	NNS
cord-018387-ci5wx26t	304	12	for	for	IN
cord-018387-ci5wx26t	304	13	the	the	DT
cord-018387-ci5wx26t	304	14	prevention	prevention	NN
cord-018387-ci5wx26t	304	15	and	and	CC
cord-018387-ci5wx26t	304	16	treatment	treatment	NN
cord-018387-ci5wx26t	304	17	of	of	IN
cord-018387-ci5wx26t	304	18	disease	disease	NN
cord-018387-ci5wx26t	304	19	Diet	Diet	NNP
cord-018387-ci5wx26t	304	20	-	-	HYPH
cord-018387-ci5wx26t	304	21	induced	induce	VBN
cord-018387-ci5wx26t	304	22	obesity	obesity	NN
cord-018387-ci5wx26t	304	23	prolongs	prolong	VBZ
cord-018387-ci5wx26t	304	24	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	304	25	and	and	CC
cord-018387-ci5wx26t	304	26	recruits	recruit	VBZ
cord-018387-ci5wx26t	304	27	CCR2(+	CCR2(+	NNP
cord-018387-ci5wx26t	304	28	)	)	-RRB-
cord-018387-ci5wx26t	304	29	monocytes	monocyte	VBZ
cord-018387-ci5wx26t	304	30	to	to	IN
cord-018387-ci5wx26t	304	31	the	the	DT
cord-018387-ci5wx26t	304	32	brain	brain	NN
cord-018387-ci5wx26t	304	33	following	follow	VBG
cord-018387-ci5wx26t	304	34	herpes	herpes	NNP
cord-018387-ci5wx26t	304	35	simplex	simplex	NNP
cord-018387-ci5wx26t	304	36	virus	virus	NN
cord-018387-ci5wx26t	304	37	(	(	-LRB-
cord-018387-ci5wx26t	304	38	HSV)-1	HSV)-1	NNP
cord-018387-ci5wx26t	304	39	latency	latency	NN
cord-018387-ci5wx26t	304	40	in	in	IN
cord-018387-ci5wx26t	304	41	mice	mouse	NNS
cord-018387-ci5wx26t	305	1	Increased	increase	VBN
cord-018387-ci5wx26t	305	2	telomerase	telomerase	NN
cord-018387-ci5wx26t	305	3	activity	activity	NN
cord-018387-ci5wx26t	305	4	and	and	CC
cord-018387-ci5wx26t	305	5	comprehensive	comprehensive	JJ
cord-018387-ci5wx26t	305	6	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	305	7	changes	change	NNS
cord-018387-ci5wx26t	306	1	:	:	:
cord-018387-ci5wx26t	306	2	a	a	DT
cord-018387-ci5wx26t	306	3	pilot	pilot	NN
cord-018387-ci5wx26t	306	4	study	study	NN
cord-018387-ci5wx26t	306	5	Healthy	Healthy	NNP
cord-018387-ci5wx26t	306	6	living	living	NN
cord-018387-ci5wx26t	306	7	is	be	VBZ
cord-018387-ci5wx26t	306	8	the	the	DT
cord-018387-ci5wx26t	306	9	best	good	JJS
cord-018387-ci5wx26t	306	10	revenge	revenge	NN
cord-018387-ci5wx26t	306	11	:	:	:
cord-018387-ci5wx26t	306	12	findings	finding	NNS
cord-018387-ci5wx26t	306	13	from	from	IN
cord-018387-ci5wx26t	306	14	the	the	DT
cord-018387-ci5wx26t	306	15	European	European	NNP
cord-018387-ci5wx26t	306	16	Prospective	Prospective	NNP
cord-018387-ci5wx26t	306	17	Investigation	Investigation	NNP
cord-018387-ci5wx26t	306	18	into	into	IN
cord-018387-ci5wx26t	306	19	Cancer	Cancer	NNP
cord-018387-ci5wx26t	306	20	and	and	CC
cord-018387-ci5wx26t	306	21	Nutrition	Nutrition	NNP
cord-018387-ci5wx26t	306	22	-	-	HYPH
cord-018387-ci5wx26t	306	23	Potsdam	Potsdam	NNP
cord-018387-ci5wx26t	306	24	study	study	NN
cord-018387-ci5wx26t	306	25	Effect	effect	NN
cord-018387-ci5wx26t	306	26	of	of	IN
cord-018387-ci5wx26t	306	27	comprehensive	comprehensive	JJ
cord-018387-ci5wx26t	306	28	lifestyle	lifestyle	NN
cord-018387-ci5wx26t	306	29	changes	change	NNS
cord-018387-ci5wx26t	306	30	on	on	IN
cord-018387-ci5wx26t	306	31	telomerase	telomerase	NN
cord-018387-ci5wx26t	306	32	activity	activity	NN
cord-018387-ci5wx26t	306	33	and	and	CC
cord-018387-ci5wx26t	306	34	telomere	telomere	NN
cord-018387-ci5wx26t	306	35	length	length	NN
cord-018387-ci5wx26t	306	36	in	in	IN
cord-018387-ci5wx26t	306	37	men	man	NNS
cord-018387-ci5wx26t	306	38	with	with	IN
cord-018387-ci5wx26t	306	39	biopsy	biopsy	NN
cord-018387-ci5wx26t	306	40	-	-	HYPH
cord-018387-ci5wx26t	306	41	proven	prove	VBN
cord-018387-ci5wx26t	306	42	low	low	JJ
cord-018387-ci5wx26t	306	43	-	-	HYPH
cord-018387-ci5wx26t	306	44	risk	risk	NN
cord-018387-ci5wx26t	306	45	prostate	prostate	NN
cord-018387-ci5wx26t	306	46	cancer	cancer	NN
cord-018387-ci5wx26t	306	47	:	:	:
cord-018387-ci5wx26t	307	1	5-year	5-year	CD
cord-018387-ci5wx26t	307	2	follow	follow	NN
cord-018387-ci5wx26t	307	3	-	-	HYPH
cord-018387-ci5wx26t	307	4	up	up	NN
cord-018387-ci5wx26t	307	5	of	of	IN
cord-018387-ci5wx26t	307	6	a	a	DT
cord-018387-ci5wx26t	307	7	descriptive	descriptive	JJ
cord-018387-ci5wx26t	307	8	pilot	pilot	NN
cord-018387-ci5wx26t	307	9	study	study	NN
cord-018387-ci5wx26t	307	10	The	the	DT
cord-018387-ci5wx26t	307	11	janus	janus	NNP
cord-018387-ci5wx26t	307	12	head	head	NN
cord-018387-ci5wx26t	307	13	of	of	IN
cord-018387-ci5wx26t	307	14	T	T	NNP
cord-018387-ci5wx26t	307	15	cell	cell	NN
cord-018387-ci5wx26t	307	16	aging	age	VBG
cord-018387-ci5wx26t	307	17	-autoimmunity	-autoimmunity	NN
cord-018387-ci5wx26t	307	18	and	and	CC
cord-018387-ci5wx26t	307	19	immunodeficiency	immunodeficiency	NN
cord-018387-ci5wx26t	307	20	Inflammation	inflammation	NN
cord-018387-ci5wx26t	307	21	&	&	CC
cord-018387-ci5wx26t	307	22	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	307	23	in	in	IN
cord-018387-ci5wx26t	307	24	human	human	JJ
cord-018387-ci5wx26t	307	25	ageing	ageing	NN
cord-018387-ci5wx26t	307	26	:	:	:
cord-018387-ci5wx26t	308	1	dendritic	dendritic	JJ
cord-018387-ci5wx26t	308	2	cells	cell	NNS
cord-018387-ci5wx26t	308	3	take	take	VBP
cord-018387-ci5wx26t	308	4	a	a	DT
cord-018387-ci5wx26t	308	5	center	center	NN
cord-018387-ci5wx26t	308	6	stage	stage	NN
cord-018387-ci5wx26t	308	7	Inflammation	inflammation	NN
cord-018387-ci5wx26t	308	8	,	,	,
cord-018387-ci5wx26t	308	9	ageing	age	VBG
cord-018387-ci5wx26t	308	10	and	and	CC
cord-018387-ci5wx26t	308	11	chronic	chronic	JJ
cord-018387-ci5wx26t	308	12	disease	disease	NN
cord-018387-ci5wx26t	309	1	As	as	IN
cord-018387-ci5wx26t	309	2	we	-PRON-	PRP
cord-018387-ci5wx26t	309	3	age	age	VBP
cord-018387-ci5wx26t	309	4	:	:	:
cord-018387-ci5wx26t	309	5	does	do	VBZ
cord-018387-ci5wx26t	309	6	slippage	slippage	NN
cord-018387-ci5wx26t	309	7	of	of	IN
cord-018387-ci5wx26t	309	8	quality	quality	NN
cord-018387-ci5wx26t	309	9	control	control	NN
cord-018387-ci5wx26t	309	10	in	in	IN
cord-018387-ci5wx26t	309	11	the	the	DT
cord-018387-ci5wx26t	309	12	immune	immune	JJ
cord-018387-ci5wx26t	309	13	system	system	NN
cord-018387-ci5wx26t	309	14	lead	lead	VBP
cord-018387-ci5wx26t	309	15	to	to	IN
cord-018387-ci5wx26t	309	16	collateral	collateral	JJ
cord-018387-ci5wx26t	309	17	damage	damage	NN
cord-018387-ci5wx26t	309	18	?	?	.
cord-018387-ci5wx26t	310	1	On	on	IN
cord-018387-ci5wx26t	310	2	the	the	DT
cord-018387-ci5wx26t	310	3	immunological	immunological	JJ
cord-018387-ci5wx26t	310	4	theory	theory	NN
cord-018387-ci5wx26t	310	5	of	of	IN
cord-018387-ci5wx26t	310	6	aging	age	VBG
cord-018387-ci5wx26t	310	7	The	the	DT
cord-018387-ci5wx26t	310	8	immunologic	immunologic	JJ
cord-018387-ci5wx26t	310	9	theory	theory	NN
cord-018387-ci5wx26t	310	10	of	of	IN
cord-018387-ci5wx26t	310	11	aging	age	VBG
cord-018387-ci5wx26t	310	12	.	.	.
cord-018387-ci5wx26t	311	1	Copenhagen	Copenhagen	NNP
cord-018387-ci5wx26t	311	2	:	:	:
cord-018387-ci5wx26t	312	1	Munksgaard	Munksgaard	NNP
cord-018387-ci5wx26t	312	2	Differences	difference	NNS
cord-018387-ci5wx26t	312	3	between	between	IN
cord-018387-ci5wx26t	312	4	naive	naive	JJ
cord-018387-ci5wx26t	312	5	and	and	CC
cord-018387-ci5wx26t	312	6	memory	memory	NN
cord-018387-ci5wx26t	312	7	T	t	NN
cord-018387-ci5wx26t	312	8	cell	cell	NN
cord-018387-ci5wx26t	312	9	phenotype	phenotype	NN
cord-018387-ci5wx26t	312	10	in	in	IN
cord-018387-ci5wx26t	312	11	Malawian	Malawian	NNP
cord-018387-ci5wx26t	312	12	and	and	CC
cord-018387-ci5wx26t	312	13	UK	UK	NNP
cord-018387-ci5wx26t	312	14	adolescents	adolescent	NNS
cord-018387-ci5wx26t	312	15	:	:	:
cord-018387-ci5wx26t	312	16	a	a	DT
cord-018387-ci5wx26t	312	17	role	role	NN
cord-018387-ci5wx26t	312	18	for	for	IN
cord-018387-ci5wx26t	312	19	Cytomegalovirus	Cytomegalovirus	NNP
cord-018387-ci5wx26t	312	20	?	?	.
cord-018387-ci5wx26t	313	1	Impact	impact	NN
cord-018387-ci5wx26t	313	2	of	of	IN
cord-018387-ci5wx26t	313	3	age	age	NN
cord-018387-ci5wx26t	313	4	,	,	,
cord-018387-ci5wx26t	313	5	sex	sex	NN
cord-018387-ci5wx26t	313	6	and	and	CC
cord-018387-ci5wx26t	313	7	CMV	CMV	NNP
cord-018387-ci5wx26t	313	8	-	-	HYPH
cord-018387-ci5wx26t	313	9	infection	infection	NN
cord-018387-ci5wx26t	313	10	on	on	IN
cord-018387-ci5wx26t	313	11	peripheral	peripheral	JJ
cord-018387-ci5wx26t	313	12	T	T	NNP
cord-018387-ci5wx26t	313	13	cell	cell	NN
cord-018387-ci5wx26t	313	14	phenotypes	phenotype	NNS
cord-018387-ci5wx26t	313	15	:	:	:
cord-018387-ci5wx26t	313	16	results	result	NNS
cord-018387-ci5wx26t	313	17	from	from	IN
cord-018387-ci5wx26t	313	18	the	the	DT
cord-018387-ci5wx26t	313	19	Berlin	Berlin	NNP
cord-018387-ci5wx26t	313	20	BASE	BASE	NNP
cord-018387-ci5wx26t	313	21	-	-	HYPH
cord-018387-ci5wx26t	313	22	II	II	NNP
cord-018387-ci5wx26t	313	23	Study	Study	NNP
cord-018387-ci5wx26t	314	1	The	the	DT
cord-018387-ci5wx26t	314	2	role	role	NN
cord-018387-ci5wx26t	314	3	of	of	IN
cord-018387-ci5wx26t	314	4	immunity	immunity	NN
cord-018387-ci5wx26t	314	5	in	in	IN
cord-018387-ci5wx26t	314	6	elderly	elderly	JJ
cord-018387-ci5wx26t	314	7	cancer	cancer	NN
cord-018387-ci5wx26t	314	8	Immunosenescence	Immunosenescence	NNP
cord-018387-ci5wx26t	314	9	in	in	IN
cord-018387-ci5wx26t	314	10	vertebrates	vertebrate	NNS
cord-018387-ci5wx26t	314	11	and	and	CC
cord-018387-ci5wx26t	314	12	invertebrates	invertebrate	NNS
cord-018387-ci5wx26t	314	13	Diversity	diversity	NN
cord-018387-ci5wx26t	314	14	and	and	CC
cord-018387-ci5wx26t	314	15	clonal	clonal	JJ
cord-018387-ci5wx26t	314	16	selection	selection	NN
cord-018387-ci5wx26t	314	17	in	in	IN
cord-018387-ci5wx26t	314	18	the	the	DT
cord-018387-ci5wx26t	314	19	human	human	JJ
cord-018387-ci5wx26t	314	20	T	t	NN
cord-018387-ci5wx26t	314	21	-	-	HYPH
cord-018387-ci5wx26t	314	22	cell	cell	NN
cord-018387-ci5wx26t	314	23	repertoire	repertoire	NN
cord-018387-ci5wx26t	314	24	Mechanisms	mechanism	NNS
cord-018387-ci5wx26t	314	25	shaping	shape	VBG
cord-018387-ci5wx26t	314	26	the	the	DT
cord-018387-ci5wx26t	314	27	naive	naive	JJ
cord-018387-ci5wx26t	314	28	T	t	NN
cord-018387-ci5wx26t	314	29	cell	cell	NN
cord-018387-ci5wx26t	314	30	repertoire	repertoire	NN
cord-018387-ci5wx26t	314	31	in	in	IN
cord-018387-ci5wx26t	314	32	the	the	DT
cord-018387-ci5wx26t	314	33	elderly	elderly	JJ
cord-018387-ci5wx26t	314	34	-Thymic	-thymic	JJ
cord-018387-ci5wx26t	314	35	involution	involution	NN
cord-018387-ci5wx26t	314	36	or	or	CC
cord-018387-ci5wx26t	314	37	peripheral	peripheral	JJ
cord-018387-ci5wx26t	314	38	homeostatic	homeostatic	JJ
cord-018387-ci5wx26t	314	39	proliferation	proliferation	NN
cord-018387-ci5wx26t	314	40	?	?	.
cord-018387-ci5wx26t	315	1	Naive	naive	JJ
cord-018387-ci5wx26t	315	2	and	and	CC
cord-018387-ci5wx26t	315	3	memory	memory	NN
cord-018387-ci5wx26t	315	4	CD8	CD8	NNP
cord-018387-ci5wx26t	315	5	T	T	NNP
cord-018387-ci5wx26t	315	6	cell	cell	NN
cord-018387-ci5wx26t	315	7	pool	pool	NN
cord-018387-ci5wx26t	315	8	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	315	9	in	in	IN
cord-018387-ci5wx26t	315	10	advanced	advanced	JJ
cord-018387-ci5wx26t	315	11	aging	aging	NN
cord-018387-ci5wx26t	315	12	:	:	:
cord-018387-ci5wx26t	315	13	impact	impact	NN
cord-018387-ci5wx26t	315	14	of	of	IN
cord-018387-ci5wx26t	315	15	age	age	NN
cord-018387-ci5wx26t	315	16	and	and	CC
cord-018387-ci5wx26t	315	17	of	of	IN
cord-018387-ci5wx26t	315	18	antigen	antigen	NN
cord-018387-ci5wx26t	315	19	-	-	HYPH
cord-018387-ci5wx26t	315	20	specific	specific	JJ
cord-018387-ci5wx26t	315	21	responses	response	NNS
cord-018387-ci5wx26t	315	22	to	to	IN
cord-018387-ci5wx26t	315	23	cytomegalovirus	cytomegalovirus	NNP
cord-018387-ci5wx26t	315	24	Peripheral	peripheral	JJ
cord-018387-ci5wx26t	315	25	blood	blood	NN
cord-018387-ci5wx26t	315	26	T	t	NN
cord-018387-ci5wx26t	315	27	-	-	HYPH
cord-018387-ci5wx26t	315	28	cell	cell	NN
cord-018387-ci5wx26t	315	29	signatures	signature	NNS
cord-018387-ci5wx26t	315	30	from	from	IN
cord-018387-ci5wx26t	315	31	high	high	JJ
cord-018387-ci5wx26t	315	32	-	-	HYPH
cord-018387-ci5wx26t	315	33	resolution	resolution	NN
cord-018387-ci5wx26t	315	34	immune	immune	JJ
cord-018387-ci5wx26t	315	35	phenotyping	phenotyping	NN
cord-018387-ci5wx26t	315	36	of	of	IN
cord-018387-ci5wx26t	315	37	gammadelta	gammadelta	NNP
cord-018387-ci5wx26t	315	38	and	and	CC
cord-018387-ci5wx26t	315	39	alphabeta	alphabeta	NNP
cord-018387-ci5wx26t	315	40	T	T	NNP
cord-018387-ci5wx26t	315	41	-	-	HYPH
cord-018387-ci5wx26t	315	42	cells	cell	NNS
cord-018387-ci5wx26t	315	43	in	in	IN
cord-018387-ci5wx26t	315	44	younger	young	JJR
cord-018387-ci5wx26t	315	45	and	and	CC
cord-018387-ci5wx26t	315	46	older	old	JJR
cord-018387-ci5wx26t	315	47	subjects	subject	NNS
cord-018387-ci5wx26t	315	48	in	in	IN
cord-018387-ci5wx26t	315	49	the	the	DT
cord-018387-ci5wx26t	315	50	Berlin	Berlin	NNP
cord-018387-ci5wx26t	315	51	Aging	Aging	NNP
cord-018387-ci5wx26t	315	52	Study	Study	NNP
cord-018387-ci5wx26t	315	53	II	II	NNP
cord-018387-ci5wx26t	315	54	A	a	DT
cord-018387-ci5wx26t	315	55	population	population	NN
cord-018387-ci5wx26t	315	56	biological	biological	JJ
cord-018387-ci5wx26t	315	57	approach	approach	NN
cord-018387-ci5wx26t	315	58	to	to	IN
cord-018387-ci5wx26t	315	59	understanding	understand	VBG
cord-018387-ci5wx26t	315	60	the	the	DT
cord-018387-ci5wx26t	315	61	maintenance	maintenance	NN
cord-018387-ci5wx26t	315	62	and	and	CC
cord-018387-ci5wx26t	315	63	loss	loss	NN
cord-018387-ci5wx26t	315	64	of	of	IN
cord-018387-ci5wx26t	315	65	the	the	DT
cord-018387-ci5wx26t	315	66	T	t	NN
cord-018387-ci5wx26t	315	67	-	-	HYPH
cord-018387-ci5wx26t	315	68	cell	cell	NN
cord-018387-ci5wx26t	315	69	repertoire	repertoire	NN
cord-018387-ci5wx26t	315	70	during	during	IN
cord-018387-ci5wx26t	315	71	aging	age	VBG
cord-018387-ci5wx26t	315	72	The	the	DT
cord-018387-ci5wx26t	315	73	influence	influence	NN
cord-018387-ci5wx26t	315	74	of	of	IN
cord-018387-ci5wx26t	315	75	age	age	NN
cord-018387-ci5wx26t	315	76	on	on	IN
cord-018387-ci5wx26t	315	77	T	t	NN
cord-018387-ci5wx26t	315	78	cell	cell	NN
cord-018387-ci5wx26t	315	79	generation	generation	NN
cord-018387-ci5wx26t	315	80	and	and	CC
cord-018387-ci5wx26t	315	81	TCR	TCR	NNP
cord-018387-ci5wx26t	315	82	diversity	diversity	NN
cord-018387-ci5wx26t	315	83	T	T	NNP
cord-018387-ci5wx26t	315	84	cell	cell	NN
cord-018387-ci5wx26t	315	85	ageing	ageing	NN
cord-018387-ci5wx26t	315	86	:	:	:
cord-018387-ci5wx26t	315	87	effects	effect	NNS
cord-018387-ci5wx26t	315	88	of	of	IN
cord-018387-ci5wx26t	315	89	age	age	NN
cord-018387-ci5wx26t	315	90	on	on	IN
cord-018387-ci5wx26t	315	91	development	development	NN
cord-018387-ci5wx26t	315	92	,	,	,
cord-018387-ci5wx26t	315	93	survival	survival	NN
cord-018387-ci5wx26t	315	94	&	&	CC
cord-018387-ci5wx26t	315	95	function	function	VBP
cord-018387-ci5wx26t	315	96	Gain	gain	NN
cord-018387-ci5wx26t	315	97	and	and	CC
cord-018387-ci5wx26t	315	98	loss	loss	NN
cord-018387-ci5wx26t	315	99	of	of	IN
cord-018387-ci5wx26t	315	100	T	t	NN
cord-018387-ci5wx26t	315	101	cell	cell	NN
cord-018387-ci5wx26t	315	102	subsets	subset	NNS
cord-018387-ci5wx26t	315	103	in	in	IN
cord-018387-ci5wx26t	315	104	old	old	JJ
cord-018387-ci5wx26t	315	105	age	age	NN
cord-018387-ci5wx26t	315	106	-	-	HYPH
cord-018387-ci5wx26t	315	107	age	age	NN
cord-018387-ci5wx26t	315	108	-	-	HYPH
cord-018387-ci5wx26t	315	109	related	relate	VBN
cord-018387-ci5wx26t	315	110	reshaping	reshaping	NN
cord-018387-ci5wx26t	315	111	of	of	IN
cord-018387-ci5wx26t	315	112	the	the	DT
cord-018387-ci5wx26t	315	113	T	T	NNP
cord-018387-ci5wx26t	315	114	cell	cell	NN
cord-018387-ci5wx26t	315	115	repertoire	repertoire	NN
cord-018387-ci5wx26t	316	1	The	the	DT
cord-018387-ci5wx26t	316	2	ageing	age	VBG
cord-018387-ci5wx26t	316	3	haematopoietic	haematopoietic	JJ
cord-018387-ci5wx26t	316	4	stem	stem	NN
cord-018387-ci5wx26t	316	5	cell	cell	NN
cord-018387-ci5wx26t	316	6	compartment	compartment	NN
cord-018387-ci5wx26t	316	7	Bone	Bone	NNP
cord-018387-ci5wx26t	316	8	marrow	marrow	NN
cord-018387-ci5wx26t	316	9	and	and	CC
cord-018387-ci5wx26t	316	10	bone	bone	NN
cord-018387-ci5wx26t	316	11	:	:	:
cord-018387-ci5wx26t	316	12	a	a	DT
cord-018387-ci5wx26t	316	13	functional	functional	JJ
cord-018387-ci5wx26t	316	14	unit	unit	NN
cord-018387-ci5wx26t	316	15	Immunosenescence	Immunosenescence	NNP
cord-018387-ci5wx26t	316	16	of	of	IN
cord-018387-ci5wx26t	316	17	ageing	age	VBG
cord-018387-ci5wx26t	316	18	Stem	Stem	NNP
cord-018387-ci5wx26t	316	19	cells	cell	NNS
cord-018387-ci5wx26t	316	20	and	and	CC
cord-018387-ci5wx26t	316	21	aging	age	VBG
cord-018387-ci5wx26t	316	22	in	in	IN
cord-018387-ci5wx26t	316	23	the	the	DT
cord-018387-ci5wx26t	316	24	hematopoietic	hematopoietic	JJ
cord-018387-ci5wx26t	316	25	system	system	NN
cord-018387-ci5wx26t	316	26	Stem	Stem	NNP
cord-018387-ci5wx26t	316	27	cells	cell	NNS
cord-018387-ci5wx26t	316	28	and	and	CC
cord-018387-ci5wx26t	316	29	the	the	DT
cord-018387-ci5wx26t	316	30	aging	age	VBG
cord-018387-ci5wx26t	316	31	hematopoietic	hematopoietic	JJ
cord-018387-ci5wx26t	316	32	system	system	NN
cord-018387-ci5wx26t	317	1	The	the	DT
cord-018387-ci5wx26t	317	2	aged	aged	JJ
cord-018387-ci5wx26t	317	3	thymus	thymus	NN
cord-018387-ci5wx26t	317	4	shows	show	VBZ
cord-018387-ci5wx26t	317	5	normal	normal	JJ
cord-018387-ci5wx26t	317	6	recruitment	recruitment	NN
cord-018387-ci5wx26t	317	7	of	of	IN
cord-018387-ci5wx26t	317	8	lymphohematopoietic	lymphohematopoietic	JJ
cord-018387-ci5wx26t	317	9	progenitors	progenitor	NNS
cord-018387-ci5wx26t	317	10	but	but	CC
cord-018387-ci5wx26t	317	11	has	have	VBZ
cord-018387-ci5wx26t	317	12	defects	defect	NNS
cord-018387-ci5wx26t	317	13	in	in	IN
cord-018387-ci5wx26t	317	14	thymic	thymic	JJ
cord-018387-ci5wx26t	317	15	epithelial	epithelial	JJ
cord-018387-ci5wx26t	317	16	cells	cell	NNS
cord-018387-ci5wx26t	318	1	The	the	DT
cord-018387-ci5wx26t	318	2	effect	effect	NN
cord-018387-ci5wx26t	318	3	of	of	IN
cord-018387-ci5wx26t	318	4	age	age	NN
cord-018387-ci5wx26t	318	5	on	on	IN
cord-018387-ci5wx26t	318	6	thymic	thymic	JJ
cord-018387-ci5wx26t	318	7	function	function	NN
cord-018387-ci5wx26t	319	1	Lymphostromal	Lymphostromal	NNP
cord-018387-ci5wx26t	319	2	interactions	interaction	NNS
cord-018387-ci5wx26t	319	3	in	in	IN
cord-018387-ci5wx26t	319	4	thymic	thymic	JJ
cord-018387-ci5wx26t	319	5	development	development	NN
cord-018387-ci5wx26t	319	6	and	and	CC
cord-018387-ci5wx26t	319	7	function	function	VB
cord-018387-ci5wx26t	319	8	Direct	direct	JJ
cord-018387-ci5wx26t	319	9	evidence	evidence	NN
cord-018387-ci5wx26t	319	10	for	for	IN
cord-018387-ci5wx26t	319	11	thymic	thymic	JJ
cord-018387-ci5wx26t	319	12	function	function	NN
cord-018387-ci5wx26t	319	13	in	in	IN
cord-018387-ci5wx26t	319	14	adult	adult	NN
cord-018387-ci5wx26t	319	15	humans	human	NNS
cord-018387-ci5wx26t	319	16	Age	Age	NNP
cord-018387-ci5wx26t	319	17	-	-	HYPH
cord-018387-ci5wx26t	319	18	related	relate	VBN
cord-018387-ci5wx26t	319	19	changes	change	NNS
cord-018387-ci5wx26t	319	20	in	in	IN
cord-018387-ci5wx26t	319	21	CD8	CD8	NNP
cord-018387-ci5wx26t	319	22	T	T	NNP
cord-018387-ci5wx26t	319	23	cell	cell	NN
cord-018387-ci5wx26t	319	24	homeostasis	homeostasis	NN
cord-018387-ci5wx26t	319	25	and	and	CC
cord-018387-ci5wx26t	319	26	immunity	immunity	NN
cord-018387-ci5wx26t	319	27	to	to	IN
cord-018387-ci5wx26t	319	28	infection	infection	NN
cord-018387-ci5wx26t	319	29	Chronic	chronic	JJ
cord-018387-ci5wx26t	319	30	inflammation	inflammation	NN
cord-018387-ci5wx26t	319	31	(	(	-LRB-
cord-018387-ci5wx26t	319	32	inflammaging	inflammage	VBG
cord-018387-ci5wx26t	319	33	)	)	-RRB-
cord-018387-ci5wx26t	319	34	and	and	CC
cord-018387-ci5wx26t	319	35	its	-PRON-	PRP$
cord-018387-ci5wx26t	319	36	potential	potential	JJ
cord-018387-ci5wx26t	319	37	contribution	contribution	NN
cord-018387-ci5wx26t	319	38	to	to	IN
cord-018387-ci5wx26t	319	39	ageassociated	ageassociate	VBN
cord-018387-ci5wx26t	319	40	diseases	disease	NNS
cord-018387-ci5wx26t	319	41	Inflamm	Inflamm	NNP
cord-018387-ci5wx26t	319	42	-	-	HYPH
cord-018387-ci5wx26t	319	43	aging	age	VBG
cord-018387-ci5wx26t	319	44	.	.	.
cord-018387-ci5wx26t	320	1	An	an	DT
cord-018387-ci5wx26t	320	2	evolutionary	evolutionary	JJ
cord-018387-ci5wx26t	320	3	perspective	perspective	NN
cord-018387-ci5wx26t	320	4	on	on	IN
cord-018387-ci5wx26t	320	5	immunosenescence	immunosenescence	JJ
cord-018387-ci5wx26t	320	6	Inflammation	inflammation	NN
cord-018387-ci5wx26t	320	7	and	and	CC
cord-018387-ci5wx26t	320	8	reactivation	reactivation	NN
cord-018387-ci5wx26t	320	9	of	of	IN
cord-018387-ci5wx26t	320	10	latent	latent	JJ
cord-018387-ci5wx26t	320	11	herpesviruses	herpesviruse	NNS
cord-018387-ci5wx26t	320	12	in	in	IN
cord-018387-ci5wx26t	320	13	older	old	JJR
cord-018387-ci5wx26t	320	14	adults	adult	NNS
cord-018387-ci5wx26t	320	15	Role	role	NN
cord-018387-ci5wx26t	320	16	of	of	IN
cord-018387-ci5wx26t	320	17	CMV	CMV	NNP
cord-018387-ci5wx26t	320	18	in	in	IN
cord-018387-ci5wx26t	320	19	immune	immune	JJ
cord-018387-ci5wx26t	320	20	senescence	senescence	NN
cord-018387-ci5wx26t	320	21	Senescence	senescence	NN
cord-018387-ci5wx26t	320	22	of	of	IN
cord-018387-ci5wx26t	320	23	the	the	DT
cord-018387-ci5wx26t	320	24	human	human	JJ
cord-018387-ci5wx26t	320	25	immune	immune	NN
cord-018387-ci5wx26t	320	26	system	system	NN
cord-018387-ci5wx26t	320	27	Functional	functional	JJ
cord-018387-ci5wx26t	320	28	assay	assay	NN
cord-018387-ci5wx26t	320	29	for	for	IN
cord-018387-ci5wx26t	320	30	human	human	JJ
cord-018387-ci5wx26t	320	31	CD4+CD25	CD4+CD25	NNP
cord-018387-ci5wx26t	320	32	+	+	CC
cord-018387-ci5wx26t	320	33	Treg	Treg	NNP
cord-018387-ci5wx26t	320	34	cells	cell	NNS
cord-018387-ci5wx26t	320	35	reveals	reveal	VBZ
cord-018387-ci5wx26t	320	36	an	an	DT
cord-018387-ci5wx26t	320	37	agedependent	agedependent	NN
cord-018387-ci5wx26t	320	38	loss	loss	NN
cord-018387-ci5wx26t	320	39	of	of	IN
cord-018387-ci5wx26t	320	40	suppressive	suppressive	JJ
cord-018387-ci5wx26t	320	41	activity	activity	NN
cord-018387-ci5wx26t	321	1	The	the	DT
cord-018387-ci5wx26t	321	2	impact	impact	NN
cord-018387-ci5wx26t	321	3	of	of	IN
cord-018387-ci5wx26t	321	4	aging	age	VBG
cord-018387-ci5wx26t	321	5	on	on	IN
cord-018387-ci5wx26t	321	6	regulatory	regulatory	JJ
cord-018387-ci5wx26t	321	7	T	T	NNP
cord-018387-ci5wx26t	321	8	-	-	HYPH
cord-018387-ci5wx26t	321	9	cells	cell	NNS
cord-018387-ci5wx26t	321	10	Acquisition	acquisition	NN
cord-018387-ci5wx26t	321	11	of	of	IN
cord-018387-ci5wx26t	321	12	suppressive	suppressive	JJ
cord-018387-ci5wx26t	321	13	activity	activity	NN
cord-018387-ci5wx26t	321	14	and	and	CC
cord-018387-ci5wx26t	321	15	natural	natural	JJ
cord-018387-ci5wx26t	321	16	killer	killer	NN
cord-018387-ci5wx26t	321	17	-	-	HYPH
cord-018387-ci5wx26t	321	18	like	like	JJ
cord-018387-ci5wx26t	321	19	cytotoxicity	cytotoxicity	NN
cord-018387-ci5wx26t	321	20	by	by	IN
cord-018387-ci5wx26t	321	21	human	human	JJ
cord-018387-ci5wx26t	321	22	alloproliferative	alloproliferative	JJ
cord-018387-ci5wx26t	321	23	"	"	``
cord-018387-ci5wx26t	321	24	helper	helper	NN
cord-018387-ci5wx26t	321	25	"	"	''
cord-018387-ci5wx26t	321	26	T	t	NN
cord-018387-ci5wx26t	321	27	cell	cell	NN
cord-018387-ci5wx26t	321	28	clones	clone	NNS
cord-018387-ci5wx26t	321	29	Regulatory	Regulatory	NNP
cord-018387-ci5wx26t	321	30	T	T	NNP
cord-018387-ci5wx26t	321	31	cells	cell	NNS
cord-018387-ci5wx26t	321	32	and	and	CC
cord-018387-ci5wx26t	321	33	the	the	DT
cord-018387-ci5wx26t	321	34	immune	immune	JJ
cord-018387-ci5wx26t	321	35	aging	aging	NN
cord-018387-ci5wx26t	321	36	process	process	NN
cord-018387-ci5wx26t	321	37	:	:	:
cord-018387-ci5wx26t	321	38	a	a	DT
cord-018387-ci5wx26t	321	39	mini	mini	JJ
cord-018387-ci5wx26t	321	40	-	-	JJ
cord-018387-ci5wx26t	321	41	review	review	JJ
cord-018387-ci5wx26t	321	42	Age	age	NN
cord-018387-ci5wx26t	321	43	-	-	HYPH
cord-018387-ci5wx26t	321	44	related	relate	VBN
cord-018387-ci5wx26t	321	45	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	321	46	Inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	321	47	markers	marker	NNS
cord-018387-ci5wx26t	321	48	in	in	IN
cord-018387-ci5wx26t	321	49	population	population	NN
cord-018387-ci5wx26t	321	50	studies	study	NNS
cord-018387-ci5wx26t	321	51	of	of	IN
cord-018387-ci5wx26t	321	52	aging	age	VBG
cord-018387-ci5wx26t	321	53	Four	Four	NNP
cord-018387-ci5wx26t	321	54	faces	face	NNS
cord-018387-ci5wx26t	321	55	of	of	IN
cord-018387-ci5wx26t	321	56	cellular	cellular	JJ
cord-018387-ci5wx26t	321	57	senescence	senescence	NN
cord-018387-ci5wx26t	322	1	The	the	DT
cord-018387-ci5wx26t	322	2	senescence	senescence	NN
cord-018387-ci5wx26t	322	3	-	-	HYPH
cord-018387-ci5wx26t	322	4	associated	associate	VBN
cord-018387-ci5wx26t	322	5	secretory	secretory	JJ
cord-018387-ci5wx26t	322	6	phenotype	phenotype	NN
cord-018387-ci5wx26t	322	7	:	:	:
cord-018387-ci5wx26t	323	1	the	the	DT
cord-018387-ci5wx26t	323	2	dark	dark	JJ
cord-018387-ci5wx26t	323	3	side	side	NN
cord-018387-ci5wx26t	323	4	of	of	IN
cord-018387-ci5wx26t	323	5	tumor	tumor	NN
cord-018387-ci5wx26t	323	6	suppression	suppression	NN
cord-018387-ci5wx26t	323	7	T	t	NN
cord-018387-ci5wx26t	323	8	-	-	HYPH
cord-018387-ci5wx26t	323	9	cell	cell	NN
cord-018387-ci5wx26t	323	10	immunity	immunity	NN
cord-018387-ci5wx26t	323	11	in	in	IN
cord-018387-ci5wx26t	323	12	the	the	DT
cord-018387-ci5wx26t	323	13	aging	age	VBG
cord-018387-ci5wx26t	323	14	human	human	JJ
cord-018387-ci5wx26t	323	15	Cellular	cellular	JJ
cord-018387-ci5wx26t	323	16	senescence	senescence	NN
cord-018387-ci5wx26t	323	17	and	and	CC
cord-018387-ci5wx26t	323	18	the	the	DT
cord-018387-ci5wx26t	323	19	senescent	senescent	JJ
cord-018387-ci5wx26t	323	20	secretory	secretory	JJ
cord-018387-ci5wx26t	323	21	phenotype	phenotype	NN
cord-018387-ci5wx26t	323	22	:	:	:
cord-018387-ci5wx26t	323	23	therapeutic	therapeutic	JJ
cord-018387-ci5wx26t	323	24	opportunities	opportunity	NNS
cord-018387-ci5wx26t	323	25	Immune	immune	VBP
cord-018387-ci5wx26t	323	26	receptor	receptor	NN
cord-018387-ci5wx26t	323	27	signaling	signal	VBG
cord-018387-ci5wx26t	323	28	,	,	,
cord-018387-ci5wx26t	323	29	aging	age	VBG
cord-018387-ci5wx26t	323	30	and	and	CC
cord-018387-ci5wx26t	323	31	autoimmunity	autoimmunity	IN
cord-018387-ci5wx26t	323	32	Human	Human	NNP
cord-018387-ci5wx26t	323	33	T	T	NNP
cord-018387-ci5wx26t	323	34	cell	cell	NN
cord-018387-ci5wx26t	323	35	aging	aging	NN
cord-018387-ci5wx26t	323	36	and	and	CC
cord-018387-ci5wx26t	323	37	the	the	DT
cord-018387-ci5wx26t	323	38	impact	impact	NN
cord-018387-ci5wx26t	323	39	of	of	IN
cord-018387-ci5wx26t	323	40	persistent	persistent	JJ
cord-018387-ci5wx26t	323	41	viral	viral	JJ
cord-018387-ci5wx26t	323	42	infections	infection	NNS
cord-018387-ci5wx26t	323	43	Telomere	Telomere	NNP
cord-018387-ci5wx26t	323	44	dysfunction	dysfunction	NN
cord-018387-ci5wx26t	323	45	,	,	,
cord-018387-ci5wx26t	323	46	autoimmunity	autoimmunity	NN
cord-018387-ci5wx26t	323	47	and	and	CC
cord-018387-ci5wx26t	323	48	aging	age	VBG
cord-018387-ci5wx26t	323	49	Aging	age	VBG
cord-018387-ci5wx26t	323	50	is	be	VBZ
cord-018387-ci5wx26t	323	51	associated	associate	VBN
cord-018387-ci5wx26t	323	52	with	with	IN
cord-018387-ci5wx26t	323	53	chronic	chronic	JJ
cord-018387-ci5wx26t	323	54	innate	innate	JJ
cord-018387-ci5wx26t	323	55	immune	immune	JJ
cord-018387-ci5wx26t	323	56	activation	activation	NN
cord-018387-ci5wx26t	323	57	and	and	CC
cord-018387-ci5wx26t	323	58	dysregulation	dysregulation	NN
cord-018387-ci5wx26t	323	59	of	of	IN
cord-018387-ci5wx26t	323	60	monocyte	monocyte	NNP
cord-018387-ci5wx26t	323	61	phenotype	phenotype	NN
cord-018387-ci5wx26t	323	62	and	and	CC
cord-018387-ci5wx26t	323	63	function	function	VB
cord-018387-ci5wx26t	323	64	Monocyte	Monocyte	NNP
cord-018387-ci5wx26t	323	65	phenotype	phenotype	NN
cord-018387-ci5wx26t	323	66	and	and	CC
cord-018387-ci5wx26t	323	67	polyfunctionality	polyfunctionality	NN
cord-018387-ci5wx26t	323	68	are	be	VBP
cord-018387-ci5wx26t	323	69	associated	associate	VBN
cord-018387-ci5wx26t	323	70	with	with	IN
cord-018387-ci5wx26t	323	71	elevated	elevated	JJ
cord-018387-ci5wx26t	323	72	soluble	soluble	JJ
cord-018387-ci5wx26t	323	73	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	323	74	markers	marker	NNS
cord-018387-ci5wx26t	323	75	,	,	,
cord-018387-ci5wx26t	323	76	cytomegalovirus	cytomegalovirus	JJ
cord-018387-ci5wx26t	323	77	infection	infection	NN
cord-018387-ci5wx26t	323	78	,	,	,
cord-018387-ci5wx26t	323	79	and	and	CC
cord-018387-ci5wx26t	323	80	functional	functional	JJ
cord-018387-ci5wx26t	323	81	and	and	CC
cord-018387-ci5wx26t	323	82	cognitive	cognitive	JJ
cord-018387-ci5wx26t	323	83	decline	decline	NN
cord-018387-ci5wx26t	323	84	in	in	IN
cord-018387-ci5wx26t	323	85	elderly	elderly	JJ
cord-018387-ci5wx26t	323	86	adults	adult	NNS
cord-018387-ci5wx26t	324	1	The	the	DT
cord-018387-ci5wx26t	324	2	modulatory	modulatory	JJ
cord-018387-ci5wx26t	324	3	effect	effect	NN
cord-018387-ci5wx26t	324	4	of	of	IN
cord-018387-ci5wx26t	324	5	age	age	NN
cord-018387-ci5wx26t	324	6	,	,	,
cord-018387-ci5wx26t	324	7	gender	gender	NN
cord-018387-ci5wx26t	324	8	and	and	CC
cord-018387-ci5wx26t	324	9	Cytomegalovirus	Cytomegalovirus	NNP
cord-018387-ci5wx26t	324	10	(	(	-LRB-
cord-018387-ci5wx26t	324	11	CMV	CMV	NNP
cord-018387-ci5wx26t	324	12	)	)	-RRB-
cord-018387-ci5wx26t	324	13	persistence	persistence	NN
cord-018387-ci5wx26t	324	14	on	on	IN
cord-018387-ci5wx26t	324	15	peripheral	peripheral	JJ
cord-018387-ci5wx26t	324	16	blood	blood	NN
cord-018387-ci5wx26t	324	17	immune	immune	JJ
cord-018387-ci5wx26t	324	18	cell	cell	NN
cord-018387-ci5wx26t	324	19	subsets	subset	NNS
cord-018387-ci5wx26t	324	20	in	in	IN
cord-018387-ci5wx26t	324	21	participants	participant	NNS
cord-018387-ci5wx26t	324	22	of	of	IN
cord-018387-ci5wx26t	324	23	the	the	DT
cord-018387-ci5wx26t	324	24	Berlin	Berlin	NNP
cord-018387-ci5wx26t	324	25	Aging	Aging	NNP
cord-018387-ci5wx26t	324	26	Study	Study	NNP
cord-018387-ci5wx26t	324	27	II	II	NNP
cord-018387-ci5wx26t	324	28	Inflammaging	Inflammaging	NNP
cord-018387-ci5wx26t	324	29	and	and	CC
cord-018387-ci5wx26t	324	30	antiinflammaging	antiinflammaging	NN
cord-018387-ci5wx26t	324	31	:	:	:
cord-018387-ci5wx26t	325	1	a	a	DT
cord-018387-ci5wx26t	325	2	systemic	systemic	JJ
cord-018387-ci5wx26t	325	3	perspective	perspective	NN
cord-018387-ci5wx26t	325	4	on	on	IN
cord-018387-ci5wx26t	325	5	aging	age	VBG
cord-018387-ci5wx26t	325	6	and	and	CC
cord-018387-ci5wx26t	325	7	longevity	longevity	NN
cord-018387-ci5wx26t	325	8	emerged	emerge	VBD
cord-018387-ci5wx26t	325	9	from	from	IN
cord-018387-ci5wx26t	325	10	studies	study	NNS
cord-018387-ci5wx26t	325	11	in	in	IN
cord-018387-ci5wx26t	325	12	humans	human	NNS
cord-018387-ci5wx26t	325	13	Contribution	Contribution	NNP
cord-018387-ci5wx26t	325	14	of	of	IN
cord-018387-ci5wx26t	325	15	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	325	16	and	and	CC
cord-018387-ci5wx26t	325	17	immunity	immunity	NN
cord-018387-ci5wx26t	325	18	to	to	IN
cord-018387-ci5wx26t	325	19	brain	brain	NN
cord-018387-ci5wx26t	325	20	aging	aging	NN
cord-018387-ci5wx26t	325	21	and	and	CC
cord-018387-ci5wx26t	325	22	the	the	DT
cord-018387-ci5wx26t	325	23	mitigating	mitigate	VBG
cord-018387-ci5wx26t	325	24	effects	effect	NNS
cord-018387-ci5wx26t	325	25	of	of	IN
cord-018387-ci5wx26t	325	26	physical	physical	JJ
cord-018387-ci5wx26t	325	27	and	and	CC
cord-018387-ci5wx26t	325	28	cognitive	cognitive	JJ
cord-018387-ci5wx26t	325	29	interventions	intervention	NNS
cord-018387-ci5wx26t	325	30	Inflammaging	Inflammaging	NNP
cord-018387-ci5wx26t	325	31	as	as	IN
cord-018387-ci5wx26t	325	32	a	a	DT
cord-018387-ci5wx26t	325	33	prodrome	prodrome	NN
cord-018387-ci5wx26t	325	34	to	to	IN
cord-018387-ci5wx26t	325	35	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	325	36	's	's	POS
cord-018387-ci5wx26t	325	37	disease	disease	NN
cord-018387-ci5wx26t	326	1	Agingdependent	agingdependent	JJ
cord-018387-ci5wx26t	326	2	changes	change	NNS
cord-018387-ci5wx26t	326	3	of	of	IN
cord-018387-ci5wx26t	326	4	microglial	microglial	JJ
cord-018387-ci5wx26t	326	5	cells	cell	NNS
cord-018387-ci5wx26t	326	6	and	and	CC
cord-018387-ci5wx26t	326	7	their	-PRON-	PRP$
cord-018387-ci5wx26t	326	8	relevance	relevance	NN
cord-018387-ci5wx26t	326	9	for	for	IN
cord-018387-ci5wx26t	326	10	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	326	11	disorders	disorder	NNS
cord-018387-ci5wx26t	326	12	Neuroinflammation	Neuroinflammation	NNP
cord-018387-ci5wx26t	326	13	and	and	CC
cord-018387-ci5wx26t	326	14	ageing	ageing	JJ
cord-018387-ci5wx26t	326	15	:	:	:
cord-018387-ci5wx26t	326	16	current	current	JJ
cord-018387-ci5wx26t	326	17	theories	theory	NNS
cord-018387-ci5wx26t	326	18	and	and	CC
cord-018387-ci5wx26t	326	19	an	an	DT
cord-018387-ci5wx26t	326	20	overview	overview	NN
cord-018387-ci5wx26t	326	21	of	of	IN
cord-018387-ci5wx26t	326	22	the	the	DT
cord-018387-ci5wx26t	326	23	data	datum	NNS
cord-018387-ci5wx26t	326	24	Brain	Brain	NNP
cord-018387-ci5wx26t	326	25	structures	structure	NNS
cord-018387-ci5wx26t	326	26	implicated	implicate	VBN
cord-018387-ci5wx26t	326	27	in	in	IN
cord-018387-ci5wx26t	326	28	inflammation	inflammation	NN
cord-018387-ci5wx26t	326	29	-	-	HYPH
cord-018387-ci5wx26t	326	30	associated	associate	VBN
cord-018387-ci5wx26t	326	31	depression	depression	NN
cord-018387-ci5wx26t	326	32	Peripheral	peripheral	JJ
cord-018387-ci5wx26t	326	33	immune	immune	JJ
cord-018387-ci5wx26t	326	34	signatures	signature	NNS
cord-018387-ci5wx26t	326	35	in	in	IN
cord-018387-ci5wx26t	326	36	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	326	37	disease	disease	NN
cord-018387-ci5wx26t	326	38	Neuroinflammation	Neuroinflammation	NNP
cord-018387-ci5wx26t	326	39	and	and	CC
cord-018387-ci5wx26t	326	40	cognitive	cognitive	JJ
cord-018387-ci5wx26t	326	41	aging	age	VBG
cord-018387-ci5wx26t	326	42	Neuroinflammation	Neuroinflammation	NNP
cord-018387-ci5wx26t	326	43	in	in	IN
cord-018387-ci5wx26t	326	44	the	the	DT
cord-018387-ci5wx26t	326	45	normal	normal	JJ
cord-018387-ci5wx26t	326	46	aging	age	VBG
cord-018387-ci5wx26t	326	47	hippocampus	hippocampus	NN
cord-018387-ci5wx26t	326	48	Aging	age	VBG
cord-018387-ci5wx26t	326	49	-	-	HYPH
cord-018387-ci5wx26t	326	50	related	relate	VBN
cord-018387-ci5wx26t	326	51	changes	change	NNS
cord-018387-ci5wx26t	326	52	in	in	IN
cord-018387-ci5wx26t	326	53	neuroimmune	neuroimmune	JJ
cord-018387-ci5wx26t	326	54	-	-	HYPH
cord-018387-ci5wx26t	326	55	endocrine	endocrine	JJ
cord-018387-ci5wx26t	326	56	function	function	NN
cord-018387-ci5wx26t	326	57	:	:	:
cord-018387-ci5wx26t	326	58	implications	implication	NNS
cord-018387-ci5wx26t	326	59	for	for	IN
cord-018387-ci5wx26t	326	60	hippocampal	hippocampal	JJ
cord-018387-ci5wx26t	326	61	-	-	HYPH
cord-018387-ci5wx26t	326	62	dependent	dependent	JJ
cord-018387-ci5wx26t	326	63	cognition	cognition	NN
cord-018387-ci5wx26t	326	64	Quality	quality	NN
cord-018387-ci5wx26t	326	65	and	and	CC
cord-018387-ci5wx26t	326	66	timing	timing	NN
cord-018387-ci5wx26t	326	67	of	of	IN
cord-018387-ci5wx26t	326	68	stressors	stressor	NNS
cord-018387-ci5wx26t	326	69	differentially	differentially	RB
cord-018387-ci5wx26t	326	70	impact	impact	VBP
cord-018387-ci5wx26t	326	71	on	on	IN
cord-018387-ci5wx26t	326	72	brain	brain	NN
cord-018387-ci5wx26t	326	73	plasticity	plasticity	NN
cord-018387-ci5wx26t	326	74	and	and	CC
cord-018387-ci5wx26t	326	75	neuroendocrine	neuroendocrine	JJ
cord-018387-ci5wx26t	326	76	-	-	HYPH
cord-018387-ci5wx26t	326	77	immune	immune	JJ
cord-018387-ci5wx26t	326	78	function	function	NN
cord-018387-ci5wx26t	326	79	in	in	IN
cord-018387-ci5wx26t	326	80	mice	mouse	NNS
cord-018387-ci5wx26t	326	81	Inflammation	inflammation	NN
cord-018387-ci5wx26t	326	82	as	as	IN
cord-018387-ci5wx26t	326	83	a	a	DT
cord-018387-ci5wx26t	326	84	psychophysiological	psychophysiological	JJ
cord-018387-ci5wx26t	326	85	biomarker	biomarker	NN
cord-018387-ci5wx26t	326	86	in	in	IN
cord-018387-ci5wx26t	326	87	chronic	chronic	JJ
cord-018387-ci5wx26t	326	88	psychosocial	psychosocial	JJ
cord-018387-ci5wx26t	326	89	stress	stress	NN
cord-018387-ci5wx26t	326	90	Dark	Dark	NNP
cord-018387-ci5wx26t	326	91	microglia	microglia	NNS
cord-018387-ci5wx26t	326	92	:	:	:
cord-018387-ci5wx26t	326	93	a	a	DT
cord-018387-ci5wx26t	326	94	new	new	JJ
cord-018387-ci5wx26t	326	95	phenotype	phenotype	NN
cord-018387-ci5wx26t	326	96	predominantly	predominantly	RB
cord-018387-ci5wx26t	326	97	associated	associate	VBN
cord-018387-ci5wx26t	326	98	with	with	IN
cord-018387-ci5wx26t	326	99	pathological	pathological	JJ
cord-018387-ci5wx26t	326	100	states	state	NNS
cord-018387-ci5wx26t	326	101	Microglia	Microglia	NNP
cord-018387-ci5wx26t	326	102	across	across	IN
cord-018387-ci5wx26t	326	103	the	the	DT
cord-018387-ci5wx26t	326	104	lifespan	lifespan	NN
cord-018387-ci5wx26t	326	105	:	:	:
cord-018387-ci5wx26t	326	106	from	from	IN
cord-018387-ci5wx26t	326	107	origin	origin	NN
cord-018387-ci5wx26t	326	108	to	to	TO
cord-018387-ci5wx26t	326	109	function	function	VB
cord-018387-ci5wx26t	326	110	in	in	IN
cord-018387-ci5wx26t	326	111	brain	brain	NN
cord-018387-ci5wx26t	326	112	development	development	NN
cord-018387-ci5wx26t	326	113	,	,	,
cord-018387-ci5wx26t	326	114	plasticity	plasticity	NN
cord-018387-ci5wx26t	326	115	and	and	CC
cord-018387-ci5wx26t	326	116	cognition	cognition	NN
cord-018387-ci5wx26t	326	117	Neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	326	118	associated	associate	VBN
cord-018387-ci5wx26t	326	119	with	with	IN
cord-018387-ci5wx26t	326	120	aging	age	VBG
cord-018387-ci5wx26t	326	121	sensitizes	sensitize	VBZ
cord-018387-ci5wx26t	326	122	the	the	DT
cord-018387-ci5wx26t	326	123	brain	brain	NN
cord-018387-ci5wx26t	326	124	to	to	IN
cord-018387-ci5wx26t	326	125	the	the	DT
cord-018387-ci5wx26t	326	126	effects	effect	NNS
cord-018387-ci5wx26t	326	127	of	of	IN
cord-018387-ci5wx26t	326	128	infection	infection	NN
cord-018387-ci5wx26t	326	129	or	or	CC
cord-018387-ci5wx26t	326	130	stress	stress	NN
cord-018387-ci5wx26t	326	131	Microglial	Microglial	NNP
cord-018387-ci5wx26t	326	132	priming	priming	NN
cord-018387-ci5wx26t	326	133	and	and	CC
cord-018387-ci5wx26t	326	134	enhanced	enhanced	JJ
cord-018387-ci5wx26t	326	135	reactivity	reactivity	NN
cord-018387-ci5wx26t	326	136	to	to	IN
cord-018387-ci5wx26t	326	137	secondary	secondary	JJ
cord-018387-ci5wx26t	326	138	insult	insult	NN
cord-018387-ci5wx26t	326	139	in	in	IN
cord-018387-ci5wx26t	326	140	aging	age	VBG
cord-018387-ci5wx26t	326	141	,	,	,
cord-018387-ci5wx26t	326	142	and	and	CC
cord-018387-ci5wx26t	326	143	traumatic	traumatic	JJ
cord-018387-ci5wx26t	326	144	CNS	CNS	NNP
cord-018387-ci5wx26t	326	145	injury	injury	NN
cord-018387-ci5wx26t	326	146	,	,	,
cord-018387-ci5wx26t	326	147	and	and	CC
cord-018387-ci5wx26t	326	148	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	326	149	disease	disease	NN
cord-018387-ci5wx26t	327	1	The	the	DT
cord-018387-ci5wx26t	327	2	role	role	NN
cord-018387-ci5wx26t	327	3	of	of	IN
cord-018387-ci5wx26t	327	4	the	the	DT
cord-018387-ci5wx26t	327	5	immune	immune	JJ
cord-018387-ci5wx26t	327	6	system	system	NN
cord-018387-ci5wx26t	327	7	in	in	IN
cord-018387-ci5wx26t	327	8	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	327	9	disorders	disorder	NNS
cord-018387-ci5wx26t	327	10	:	:	:
cord-018387-ci5wx26t	327	11	adaptive	adaptive	JJ
cord-018387-ci5wx26t	327	12	or	or	CC
cord-018387-ci5wx26t	327	13	maladaptive	maladaptive	JJ
cord-018387-ci5wx26t	327	14	?	?	.
cord-018387-ci5wx26t	328	1	Immune	immune	JJ
cord-018387-ci5wx26t	328	2	aging	aging	NN
cord-018387-ci5wx26t	328	3	,	,	,
cord-018387-ci5wx26t	328	4	dysmetabolism	dysmetabolism	NN
cord-018387-ci5wx26t	328	5	,	,	,
cord-018387-ci5wx26t	328	6	and	and	CC
cord-018387-ci5wx26t	328	7	inflammation	inflammation	NN
cord-018387-ci5wx26t	328	8	in	in	IN
cord-018387-ci5wx26t	328	9	neurological	neurological	JJ
cord-018387-ci5wx26t	328	10	diseases	disease	NNS
cord-018387-ci5wx26t	328	11	T	T	NNP
cord-018387-ci5wx26t	328	12	cell	cell	NN
cord-018387-ci5wx26t	328	13	recruitment	recruitment	NN
cord-018387-ci5wx26t	328	14	in	in	IN
cord-018387-ci5wx26t	328	15	the	the	DT
cord-018387-ci5wx26t	328	16	brain	brain	NN
cord-018387-ci5wx26t	328	17	during	during	IN
cord-018387-ci5wx26t	328	18	normal	normal	JJ
cord-018387-ci5wx26t	328	19	aging	age	VBG
cord-018387-ci5wx26t	328	20	Inflammation	inflammation	NN
cord-018387-ci5wx26t	328	21	,	,	,
cord-018387-ci5wx26t	328	22	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	328	23	diseases	disease	NNS
cord-018387-ci5wx26t	328	24	,	,	,
cord-018387-ci5wx26t	328	25	and	and	CC
cord-018387-ci5wx26t	328	26	environmental	environmental	JJ
cord-018387-ci5wx26t	328	27	exposures	exposure	NNS
cord-018387-ci5wx26t	328	28	Role	role	NN
cord-018387-ci5wx26t	328	29	of	of	IN
cord-018387-ci5wx26t	328	30	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	328	31	in	in	IN
cord-018387-ci5wx26t	328	32	neurodegenerative	neurodegenerative	JJ
cord-018387-ci5wx26t	328	33	diseases	disease	NNS
cord-018387-ci5wx26t	328	34	(	(	-LRB-
cord-018387-ci5wx26t	328	35	review	review	NN
cord-018387-ci5wx26t	328	36	)	)	-RRB-
cord-018387-ci5wx26t	329	1	Inflammation	inflammation	NN
cord-018387-ci5wx26t	329	2	in	in	IN
cord-018387-ci5wx26t	329	3	schizophrenia	schizophrenia	NN
cord-018387-ci5wx26t	329	4	:	:	:
cord-018387-ci5wx26t	329	5	a	a	DT
cord-018387-ci5wx26t	329	6	question	question	NN
cord-018387-ci5wx26t	329	7	of	of	IN
cord-018387-ci5wx26t	329	8	balance	balance	NN
cord-018387-ci5wx26t	329	9	Dietary	dietary	JJ
cord-018387-ci5wx26t	329	10	phytochemicals	phytochemical	NNS
cord-018387-ci5wx26t	329	11	in	in	IN
cord-018387-ci5wx26t	329	12	neuroimmunoaging	neuroimmunoaging	NN
cord-018387-ci5wx26t	329	13	:	:	:
cord-018387-ci5wx26t	329	14	a	a	DT
cord-018387-ci5wx26t	329	15	new	new	JJ
cord-018387-ci5wx26t	329	16	therapeutic	therapeutic	JJ
cord-018387-ci5wx26t	329	17	possibility	possibility	NN
cord-018387-ci5wx26t	329	18	for	for	IN
cord-018387-ci5wx26t	329	19	humans	human	NNS
cord-018387-ci5wx26t	329	20	?	?	.
cord-018387-ci5wx26t	330	1	The	the	DT
cord-018387-ci5wx26t	330	2	caloric	caloric	JJ
cord-018387-ci5wx26t	330	3	restriction	restriction	NN
cord-018387-ci5wx26t	330	4	paradigm	paradigm	NN
cord-018387-ci5wx26t	330	5	:	:	:
cord-018387-ci5wx26t	330	6	implications	implication	NNS
cord-018387-ci5wx26t	330	7	for	for	IN
cord-018387-ci5wx26t	330	8	healthy	healthy	JJ
cord-018387-ci5wx26t	330	9	human	human	JJ
cord-018387-ci5wx26t	330	10	aging	age	VBG
cord-018387-ci5wx26t	330	11	Mice	mouse	NNS
cord-018387-ci5wx26t	330	12	and	and	CC
cord-018387-ci5wx26t	330	13	flies	fly	NNS
cord-018387-ci5wx26t	330	14	and	and	CC
cord-018387-ci5wx26t	330	15	monkeys	monkey	NNS
cord-018387-ci5wx26t	330	16	too	too	RB
cord-018387-ci5wx26t	330	17	:	:	:
cord-018387-ci5wx26t	330	18	caloric	caloric	JJ
cord-018387-ci5wx26t	330	19	restriction	restriction	NN
cord-018387-ci5wx26t	330	20	rejuvenates	rejuvenate	VBZ
cord-018387-ci5wx26t	330	21	the	the	DT
cord-018387-ci5wx26t	330	22	aging	age	VBG
cord-018387-ci5wx26t	330	23	immune	immune	JJ
cord-018387-ci5wx26t	330	24	system	system	NN
cord-018387-ci5wx26t	330	25	of	of	IN
cord-018387-ci5wx26t	330	26	non	non	JJ
cord-018387-ci5wx26t	330	27	-	-	JJ
cord-018387-ci5wx26t	330	28	human	human	JJ
cord-018387-ci5wx26t	330	29	primates	primate	NNS
cord-018387-ci5wx26t	331	1	Is	be	VBZ
cord-018387-ci5wx26t	331	2	dietary	dietary	JJ
cord-018387-ci5wx26t	331	3	restriction	restriction	NN
cord-018387-ci5wx26t	331	4	beneficial	beneficial	JJ
cord-018387-ci5wx26t	331	5	for	for	IN
cord-018387-ci5wx26t	331	6	human	human	JJ
cord-018387-ci5wx26t	331	7	health	health	NN
cord-018387-ci5wx26t	331	8	,	,	,
cord-018387-ci5wx26t	331	9	such	such	JJ
cord-018387-ci5wx26t	331	10	as	as	IN
cord-018387-ci5wx26t	331	11	for	for	IN
cord-018387-ci5wx26t	331	12	immune	immune	JJ
cord-018387-ci5wx26t	331	13	function	function	NN
cord-018387-ci5wx26t	331	14	?	?	.
cord-018387-ci5wx26t	332	1	Lifespan	lifespan	NN
cord-018387-ci5wx26t	332	2	-	-	HYPH
cord-018387-ci5wx26t	332	3	extending	extend	VBG
cord-018387-ci5wx26t	332	4	caloric	caloric	JJ
cord-018387-ci5wx26t	332	5	restriction	restriction	NN
cord-018387-ci5wx26t	332	6	or	or	CC
cord-018387-ci5wx26t	332	7	mTOR	mtor	NN
cord-018387-ci5wx26t	332	8	inhibition	inhibition	NN
cord-018387-ci5wx26t	332	9	impair	impair	VB
cord-018387-ci5wx26t	332	10	adaptive	adaptive	JJ
cord-018387-ci5wx26t	332	11	immunity	immunity	NN
cord-018387-ci5wx26t	332	12	of	of	IN
cord-018387-ci5wx26t	332	13	old	old	JJ
cord-018387-ci5wx26t	332	14	mice	mouse	NNS
cord-018387-ci5wx26t	332	15	by	by	IN
cord-018387-ci5wx26t	332	16	distinct	distinct	JJ
cord-018387-ci5wx26t	332	17	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	332	18	Long	long	JJ
cord-018387-ci5wx26t	332	19	-	-	HYPH
cord-018387-ci5wx26t	332	20	term	term	NN
cord-018387-ci5wx26t	332	21	moderate	moderate	JJ
cord-018387-ci5wx26t	332	22	calorie	calorie	NN
cord-018387-ci5wx26t	332	23	restriction	restriction	NN
cord-018387-ci5wx26t	332	24	inhibits	inhibit	VBZ
cord-018387-ci5wx26t	332	25	inflammation	inflammation	NN
cord-018387-ci5wx26t	332	26	without	without	IN
cord-018387-ci5wx26t	332	27	impairing	impair	VBG
cord-018387-ci5wx26t	332	28	cell	cell	NN
cord-018387-ci5wx26t	332	29	-	-	HYPH
cord-018387-ci5wx26t	332	30	mediated	mediate	VBN
cord-018387-ci5wx26t	332	31	immunity	immunity	NN
cord-018387-ci5wx26t	332	32	:	:	:
cord-018387-ci5wx26t	332	33	a	a	DT
cord-018387-ci5wx26t	332	34	randomized	randomized	JJ
cord-018387-ci5wx26t	332	35	controlled	control	VBN
cord-018387-ci5wx26t	332	36	trial	trial	NN
cord-018387-ci5wx26t	332	37	in	in	IN
cord-018387-ci5wx26t	332	38	non	non	JJ
cord-018387-ci5wx26t	332	39	-	-	JJ
cord-018387-ci5wx26t	332	40	obese	obese	JJ
cord-018387-ci5wx26t	332	41	humans	human	NNS
cord-018387-ci5wx26t	333	1	The	the	DT
cord-018387-ci5wx26t	333	2	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	333	3	status	status	NN
cord-018387-ci5wx26t	333	4	of	of	IN
cord-018387-ci5wx26t	333	5	old	old	JJ
cord-018387-ci5wx26t	333	6	age	age	NN
cord-018387-ci5wx26t	333	7	can	can	MD
cord-018387-ci5wx26t	333	8	be	be	VB
cord-018387-ci5wx26t	333	9	nurtured	nurture	VBN
cord-018387-ci5wx26t	333	10	from	from	IN
cord-018387-ci5wx26t	333	11	the	the	DT
cord-018387-ci5wx26t	333	12	intestinal	intestinal	JJ
cord-018387-ci5wx26t	333	13	environment	environment	NN
cord-018387-ci5wx26t	333	14	Aging	age	VBG
cord-018387-ci5wx26t	333	15	of	of	IN
cord-018387-ci5wx26t	333	16	the	the	DT
cord-018387-ci5wx26t	333	17	human	human	JJ
cord-018387-ci5wx26t	333	18	metaorganism	metaorganism	NN
cord-018387-ci5wx26t	333	19	:	:	:
cord-018387-ci5wx26t	333	20	the	the	DT
cord-018387-ci5wx26t	333	21	microbial	microbial	JJ
cord-018387-ci5wx26t	333	22	counterpart	counterpart	NN
cord-018387-ci5wx26t	333	23	Through	through	IN
cord-018387-ci5wx26t	333	24	ageing	age	VBG
cord-018387-ci5wx26t	333	25	,	,	,
cord-018387-ci5wx26t	333	26	and	and	CC
cord-018387-ci5wx26t	333	27	beyond	beyond	IN
cord-018387-ci5wx26t	333	28	:	:	:
cord-018387-ci5wx26t	333	29	gut	gut	VB
cord-018387-ci5wx26t	333	30	microbiota	microbiota	NNS
cord-018387-ci5wx26t	333	31	and	and	CC
cord-018387-ci5wx26t	333	32	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	333	33	status	status	NN
cord-018387-ci5wx26t	333	34	in	in	IN
cord-018387-ci5wx26t	333	35	seniors	senior	NNS
cord-018387-ci5wx26t	333	36	and	and	CC
cord-018387-ci5wx26t	333	37	centenarians	centenarian	NNS
cord-018387-ci5wx26t	333	38	Probiotics	probiotic	NNS
cord-018387-ci5wx26t	333	39	and	and	CC
cord-018387-ci5wx26t	333	40	immune	immune	JJ
cord-018387-ci5wx26t	333	41	response	response	NN
cord-018387-ci5wx26t	333	42	Immunologic	immunologic	JJ
cord-018387-ci5wx26t	333	43	effects	effect	NNS
cord-018387-ci5wx26t	333	44	of	of	IN
cord-018387-ci5wx26t	333	45	yogurt	yogurt	NN
cord-018387-ci5wx26t	333	46	Effects	effect	NNS
cord-018387-ci5wx26t	333	47	of	of	IN
cord-018387-ci5wx26t	333	48	a	a	DT
cord-018387-ci5wx26t	333	49	fermented	ferment	VBN
cord-018387-ci5wx26t	333	50	milk	milk	NN
cord-018387-ci5wx26t	333	51	drink	drink	NN
cord-018387-ci5wx26t	333	52	containing	contain	VBG
cord-018387-ci5wx26t	333	53	Lactobacillus	lactobacillus	NN
cord-018387-ci5wx26t	333	54	casei	casei	NN
cord-018387-ci5wx26t	333	55	strain	strain	NN
cord-018387-ci5wx26t	333	56	Shirota	Shirota	NNP
cord-018387-ci5wx26t	333	57	on	on	IN
cord-018387-ci5wx26t	333	58	the	the	DT
cord-018387-ci5wx26t	333	59	human	human	JJ
cord-018387-ci5wx26t	333	60	NK	nk	NN
cord-018387-ci5wx26t	333	61	-	-	HYPH
cord-018387-ci5wx26t	333	62	cell	cell	NN
cord-018387-ci5wx26t	333	63	activity	activity	NN
cord-018387-ci5wx26t	334	1	The	the	DT
cord-018387-ci5wx26t	334	2	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	334	3	status	status	NN
cord-018387-ci5wx26t	334	4	of	of	IN
cord-018387-ci5wx26t	334	5	the	the	DT
cord-018387-ci5wx26t	334	6	elderly	elderly	JJ
cord-018387-ci5wx26t	334	7	:	:	:
cord-018387-ci5wx26t	334	8	the	the	DT
cord-018387-ci5wx26t	334	9	intestinal	intestinal	JJ
cord-018387-ci5wx26t	334	10	contribution	contribution	NN
cord-018387-ci5wx26t	334	11	Modulation	modulation	NN
cord-018387-ci5wx26t	334	12	of	of	IN
cord-018387-ci5wx26t	334	13	the	the	DT
cord-018387-ci5wx26t	334	14	fecal	fecal	JJ
cord-018387-ci5wx26t	334	15	microflora	microflora	NN
cord-018387-ci5wx26t	334	16	profile	profile	NN
cord-018387-ci5wx26t	334	17	and	and	CC
cord-018387-ci5wx26t	334	18	immune	immune	JJ
cord-018387-ci5wx26t	334	19	function	function	NN
cord-018387-ci5wx26t	334	20	by	by	IN
cord-018387-ci5wx26t	334	21	a	a	DT
cord-018387-ci5wx26t	334	22	novel	novel	JJ
cord-018387-ci5wx26t	334	23	trans	trans	JJ
cord-018387-ci5wx26t	334	24	-	-	JJ
cord-018387-ci5wx26t	334	25	galactooligosaccharide	galactooligosaccharide	JJ
cord-018387-ci5wx26t	334	26	mixture	mixture	NN
cord-018387-ci5wx26t	334	27	(	(	-LRB-
cord-018387-ci5wx26t	334	28	B	b	NN
cord-018387-ci5wx26t	334	29	-	-	HYPH
cord-018387-ci5wx26t	334	30	GOS	GOS	NNP
cord-018387-ci5wx26t	334	31	)	)	-RRB-
cord-018387-ci5wx26t	334	32	in	in	IN
cord-018387-ci5wx26t	334	33	healthy	healthy	JJ
cord-018387-ci5wx26t	334	34	elderly	elderly	JJ
cord-018387-ci5wx26t	334	35	volunteers	volunteer	NNS
cord-018387-ci5wx26t	335	1	A	a	DT
cord-018387-ci5wx26t	335	2	probiotic	probiotic	JJ
cord-018387-ci5wx26t	335	3	fermented	ferment	VBN
cord-018387-ci5wx26t	335	4	dairy	dairy	NN
cord-018387-ci5wx26t	335	5	drink	drink	NN
cord-018387-ci5wx26t	335	6	improves	improve	VBZ
cord-018387-ci5wx26t	335	7	antibody	antibody	NN
cord-018387-ci5wx26t	335	8	response	response	NN
cord-018387-ci5wx26t	335	9	to	to	IN
cord-018387-ci5wx26t	335	10	influenza	influenza	NN
cord-018387-ci5wx26t	335	11	vaccination	vaccination	NN
cord-018387-ci5wx26t	335	12	in	in	IN
cord-018387-ci5wx26t	335	13	the	the	DT
cord-018387-ci5wx26t	335	14	elderly	elderly	JJ
cord-018387-ci5wx26t	335	15	in	in	IN
cord-018387-ci5wx26t	335	16	two	two	CD
cord-018387-ci5wx26t	335	17	randomised	randomised	JJ
cord-018387-ci5wx26t	335	18	controlled	control	VBN
cord-018387-ci5wx26t	335	19	trials	trial	NNS
cord-018387-ci5wx26t	335	20	Antibody	Antibody	NNP
cord-018387-ci5wx26t	335	21	response	response	NN
cord-018387-ci5wx26t	335	22	to	to	IN
cord-018387-ci5wx26t	335	23	influenza	influenza	NN
cord-018387-ci5wx26t	335	24	vaccination	vaccination	NN
cord-018387-ci5wx26t	335	25	in	in	IN
cord-018387-ci5wx26t	335	26	the	the	DT
cord-018387-ci5wx26t	335	27	elderly	elderly	JJ
cord-018387-ci5wx26t	335	28	:	:	:
cord-018387-ci5wx26t	335	29	a	a	DT
cord-018387-ci5wx26t	335	30	quantitative	quantitative	JJ
cord-018387-ci5wx26t	335	31	review	review	NN
cord-018387-ci5wx26t	335	32	Treg	Treg	NNP
cord-018387-ci5wx26t	335	33	induction	induction	NN
cord-018387-ci5wx26t	335	34	by	by	IN
cord-018387-ci5wx26t	335	35	a	a	DT
cord-018387-ci5wx26t	335	36	rationally	rationally	RB
cord-018387-ci5wx26t	335	37	selected	select	VBN
cord-018387-ci5wx26t	335	38	mixture	mixture	NN
cord-018387-ci5wx26t	335	39	of	of	IN
cord-018387-ci5wx26t	335	40	Clostridia	Clostridia	NNP
cord-018387-ci5wx26t	335	41	strains	strain	NNS
cord-018387-ci5wx26t	335	42	from	from	IN
cord-018387-ci5wx26t	335	43	the	the	DT
cord-018387-ci5wx26t	335	44	human	human	JJ
cord-018387-ci5wx26t	335	45	microbiota	microbiota	NN
cord-018387-ci5wx26t	335	46	Raw	Raw	NNP
cord-018387-ci5wx26t	335	47	and	and	CC
cord-018387-ci5wx26t	335	48	cooked	cook	VBN
cord-018387-ci5wx26t	335	49	vegetables	vegetable	NNS
cord-018387-ci5wx26t	335	50	,	,	,
cord-018387-ci5wx26t	335	51	fruits	fruit	NNS
cord-018387-ci5wx26t	335	52	,	,	,
cord-018387-ci5wx26t	335	53	selected	select	VBN
cord-018387-ci5wx26t	335	54	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	335	55	,	,	,
cord-018387-ci5wx26t	335	56	and	and	CC
cord-018387-ci5wx26t	335	57	breast	breast	NN
cord-018387-ci5wx26t	335	58	cancer	cancer	NN
cord-018387-ci5wx26t	335	59	risk	risk	NN
cord-018387-ci5wx26t	335	60	:	:	:
cord-018387-ci5wx26t	336	1	a	a	DT
cord-018387-ci5wx26t	336	2	case	case	NN
cord-018387-ci5wx26t	336	3	-	-	HYPH
cord-018387-ci5wx26t	336	4	control	control	NN
cord-018387-ci5wx26t	336	5	study	study	NN
cord-018387-ci5wx26t	336	6	in	in	IN
cord-018387-ci5wx26t	336	7	Germany	Germany	NNP
cord-018387-ci5wx26t	336	8	Are	be	VBP
cord-018387-ci5wx26t	336	9	vitamin	vitamin	NN
cord-018387-ci5wx26t	336	10	and	and	CC
cord-018387-ci5wx26t	336	11	mineral	mineral	NN
cord-018387-ci5wx26t	336	12	deficiencies	deficiency	NNS
cord-018387-ci5wx26t	336	13	a	a	DT
cord-018387-ci5wx26t	336	14	major	major	JJ
cord-018387-ci5wx26t	336	15	cancer	cancer	NN
cord-018387-ci5wx26t	336	16	risk	risk	NN
cord-018387-ci5wx26t	336	17	?	?	.
cord-018387-ci5wx26t	337	1	Structure	structure	NN
cord-018387-ci5wx26t	337	2	-	-	HYPH
cord-018387-ci5wx26t	337	3	dependent	dependent	JJ
cord-018387-ci5wx26t	337	4	inhibition	inhibition	NN
cord-018387-ci5wx26t	337	5	of	of	IN
cord-018387-ci5wx26t	337	6	bladder	bladder	NN
cord-018387-ci5wx26t	337	7	and	and	CC
cord-018387-ci5wx26t	337	8	pancreatic	pancreatic	JJ
cord-018387-ci5wx26t	337	9	cancer	cancer	NN
cord-018387-ci5wx26t	337	10	cell	cell	NN
cord-018387-ci5wx26t	337	11	growth	growth	NN
cord-018387-ci5wx26t	337	12	by	by	IN
cord-018387-ci5wx26t	337	13	2-substituted	2-substituted	CD
cord-018387-ci5wx26t	337	14	glycyrrhetinic	glycyrrhetinic	NNP
cord-018387-ci5wx26t	337	15	and	and	CC
cord-018387-ci5wx26t	337	16	ursolic	ursolic	JJ
cord-018387-ci5wx26t	337	17	acid	acid	NNP
cord-018387-ci5wx26t	338	1	derivatives	derivative	NNS
cord-018387-ci5wx26t	338	2	Black	black	JJ
cord-018387-ci5wx26t	338	3	soy	soy	NN
cord-018387-ci5wx26t	338	4	peptide	peptide	NN
cord-018387-ci5wx26t	338	5	supplementation	supplementation	NN
cord-018387-ci5wx26t	338	6	improves	improve	VBZ
cord-018387-ci5wx26t	338	7	glucose	glucose	NN
cord-018387-ci5wx26t	338	8	control	control	NN
cord-018387-ci5wx26t	338	9	in	in	IN
cord-018387-ci5wx26t	338	10	subjects	subject	NNS
cord-018387-ci5wx26t	338	11	with	with	IN
cord-018387-ci5wx26t	338	12	prediabetes	prediabete	NNS
cord-018387-ci5wx26t	338	13	and	and	CC
cord-018387-ci5wx26t	338	14	newly	newly	RB
cord-018387-ci5wx26t	338	15	diagnosed	diagnose	VBN
cord-018387-ci5wx26t	338	16	type	type	NN
cord-018387-ci5wx26t	338	17	2	2	CD
cord-018387-ci5wx26t	338	18	diabetes	diabetes	NN
cord-018387-ci5wx26t	338	19	mellitus	mellitus	NN
cord-018387-ci5wx26t	338	20	Age	Age	NNP
cord-018387-ci5wx26t	338	21	-	-	HYPH
cord-018387-ci5wx26t	338	22	associated	associate	VBN
cord-018387-ci5wx26t	338	23	chronic	chronic	JJ
cord-018387-ci5wx26t	338	24	diseases	disease	NNS
cord-018387-ci5wx26t	338	25	require	require	VBP
cord-018387-ci5wx26t	338	26	age	age	NN
cord-018387-ci5wx26t	338	27	-	-	HYPH
cord-018387-ci5wx26t	338	28	old	old	JJ
cord-018387-ci5wx26t	338	29	medicine	medicine	NN
cord-018387-ci5wx26t	338	30	:	:	:
cord-018387-ci5wx26t	338	31	role	role	NN
cord-018387-ci5wx26t	338	32	of	of	IN
cord-018387-ci5wx26t	338	33	chronic	chronic	JJ
cord-018387-ci5wx26t	338	34	inflammation	inflammation	NN
cord-018387-ci5wx26t	338	35	Ursolic	Ursolic	NNP
cord-018387-ci5wx26t	338	36	acid	acid	NN
cord-018387-ci5wx26t	338	37	overcomes	overcome	VBZ
cord-018387-ci5wx26t	338	38	Bcl-2-mediated	bcl-2-mediated	JJ
cord-018387-ci5wx26t	338	39	resistance	resistance	NN
cord-018387-ci5wx26t	338	40	to	to	IN
cord-018387-ci5wx26t	338	41	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	338	42	in	in	IN
cord-018387-ci5wx26t	338	43	prostate	prostate	NN
cord-018387-ci5wx26t	338	44	cancer	cancer	NN
cord-018387-ci5wx26t	338	45	cells	cell	NNS
cord-018387-ci5wx26t	338	46	involving	involve	VBG
cord-018387-ci5wx26t	338	47	activation	activation	NN
cord-018387-ci5wx26t	338	48	of	of	IN
cord-018387-ci5wx26t	338	49	JNK	JNK	NNP
cord-018387-ci5wx26t	338	50	-	-	HYPH
cord-018387-ci5wx26t	338	51	induced	induce	VBN
cord-018387-ci5wx26t	338	52	Bcl-2	Bcl-2	NNP
cord-018387-ci5wx26t	338	53	phosphorylation	phosphorylation	NN
cord-018387-ci5wx26t	338	54	and	and	CC
cord-018387-ci5wx26t	338	55	degradation	degradation	NN
cord-018387-ci5wx26t	338	56	Molecular	molecular	JJ
cord-018387-ci5wx26t	338	57	targets	target	NNS
cord-018387-ci5wx26t	338	58	of	of	IN
cord-018387-ci5wx26t	338	59	dietary	dietary	JJ
cord-018387-ci5wx26t	338	60	agents	agent	NNS
cord-018387-ci5wx26t	338	61	for	for	IN
cord-018387-ci5wx26t	338	62	prevention	prevention	NN
cord-018387-ci5wx26t	338	63	and	and	CC
cord-018387-ci5wx26t	338	64	therapy	therapy	NN
cord-018387-ci5wx26t	338	65	of	of	IN
cord-018387-ci5wx26t	338	66	cancer	cancer	NN
cord-018387-ci5wx26t	338	67	Anti	anti	JJ
cord-018387-ci5wx26t	338	68	-	-	JJ
cord-018387-ci5wx26t	338	69	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	338	70	diets	diet	NNS
cord-018387-ci5wx26t	339	1	Neuroprotective	neuroprotective	JJ
cord-018387-ci5wx26t	339	2	effect	effect	NN
cord-018387-ci5wx26t	339	3	of	of	IN
cord-018387-ci5wx26t	339	4	natural	natural	JJ
cord-018387-ci5wx26t	339	5	products	product	NNS
cord-018387-ci5wx26t	339	6	against	against	IN
cord-018387-ci5wx26t	339	7	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	339	8	's	's	POS
cord-018387-ci5wx26t	339	9	disease	disease	NN
cord-018387-ci5wx26t	339	10	Nutritional	nutritional	JJ
cord-018387-ci5wx26t	339	11	modulation	modulation	NN
cord-018387-ci5wx26t	339	12	of	of	IN
cord-018387-ci5wx26t	339	13	age	age	NN
cord-018387-ci5wx26t	339	14	-	-	HYPH
cord-018387-ci5wx26t	339	15	related	relate	VBN
cord-018387-ci5wx26t	339	16	changes	change	NNS
cord-018387-ci5wx26t	339	17	in	in	IN
cord-018387-ci5wx26t	339	18	the	the	DT
cord-018387-ci5wx26t	339	19	immune	immune	JJ
cord-018387-ci5wx26t	339	20	system	system	NN
cord-018387-ci5wx26t	339	21	and	and	CC
cord-018387-ci5wx26t	339	22	risk	risk	NN
cord-018387-ci5wx26t	339	23	of	of	IN
cord-018387-ci5wx26t	339	24	infection	infection	NN
cord-018387-ci5wx26t	340	1	The	the	DT
cord-018387-ci5wx26t	340	2	beneficial	beneficial	JJ
cord-018387-ci5wx26t	340	3	role	role	NN
cord-018387-ci5wx26t	340	4	of	of	IN
cord-018387-ci5wx26t	340	5	anti	anti	JJ
cord-018387-ci5wx26t	340	6	-	-	JJ
cord-018387-ci5wx26t	340	7	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	340	8	dietary	dietary	JJ
cord-018387-ci5wx26t	340	9	ingredients	ingredient	NNS
cord-018387-ci5wx26t	340	10	in	in	IN
cord-018387-ci5wx26t	340	11	attenuating	attenuate	VBG
cord-018387-ci5wx26t	340	12	markers	marker	NNS
cord-018387-ci5wx26t	340	13	of	of	IN
cord-018387-ci5wx26t	340	14	chronic	chronic	JJ
cord-018387-ci5wx26t	340	15	low	low	JJ
cord-018387-ci5wx26t	340	16	-	-	HYPH
cord-018387-ci5wx26t	340	17	grade	grade	NN
cord-018387-ci5wx26t	340	18	inflammation	inflammation	NN
cord-018387-ci5wx26t	340	19	in	in	IN
cord-018387-ci5wx26t	340	20	aging	age	VBG
cord-018387-ci5wx26t	340	21	Inflammasomes	Inflammasomes	NNP
cord-018387-ci5wx26t	340	22	,	,	,
cord-018387-ci5wx26t	340	23	hormesis	hormesis	NN
cord-018387-ci5wx26t	340	24	,	,	,
cord-018387-ci5wx26t	340	25	and	and	CC
cord-018387-ci5wx26t	340	26	antioxidants	antioxidant	NNS
cord-018387-ci5wx26t	340	27	in	in	IN
cord-018387-ci5wx26t	340	28	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	340	29	:	:	:
cord-018387-ci5wx26t	340	30	role	role	NN
cord-018387-ci5wx26t	340	31	of	of	IN
cord-018387-ci5wx26t	340	32	NRLP3	nrlp3	NN
cord-018387-ci5wx26t	340	33	in	in	IN
cord-018387-ci5wx26t	340	34	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	340	35	disease	disease	NN
cord-018387-ci5wx26t	341	1	A	a	DT
cord-018387-ci5wx26t	341	2	unique	unique	JJ
cord-018387-ci5wx26t	341	3	combination	combination	NN
cord-018387-ci5wx26t	341	4	of	of	IN
cord-018387-ci5wx26t	341	5	micronutrients	micronutrient	NNS
cord-018387-ci5wx26t	341	6	rejuvenates	rejuvenate	VBZ
cord-018387-ci5wx26t	341	7	cognitive	cognitive	JJ
cord-018387-ci5wx26t	341	8	performance	performance	NN
cord-018387-ci5wx26t	341	9	in	in	IN
cord-018387-ci5wx26t	341	10	aged	aged	JJ
cord-018387-ci5wx26t	341	11	mice	mouse	NNS
cord-018387-ci5wx26t	341	12	Diet	diet	NN
cord-018387-ci5wx26t	341	13	and	and	CC
cord-018387-ci5wx26t	341	14	inflammation	inflammation	NN
cord-018387-ci5wx26t	341	15	:	:	:
cord-018387-ci5wx26t	341	16	possible	possible	JJ
cord-018387-ci5wx26t	341	17	effects	effect	NNS
cord-018387-ci5wx26t	341	18	on	on	IN
cord-018387-ci5wx26t	341	19	immunity	immunity	NN
cord-018387-ci5wx26t	341	20	,	,	,
cord-018387-ci5wx26t	341	21	chronic	chronic	JJ
cord-018387-ci5wx26t	341	22	diseases	disease	NNS
cord-018387-ci5wx26t	341	23	,	,	,
cord-018387-ci5wx26t	341	24	and	and	CC
cord-018387-ci5wx26t	341	25	life	life	NN
cord-018387-ci5wx26t	341	26	span	span	NN
cord-018387-ci5wx26t	342	1	Resveratrol	resveratrol	NN
cord-018387-ci5wx26t	342	2	attenuates	attenuate	VBZ
cord-018387-ci5wx26t	342	3	hypoxia	hypoxia	NN
cord-018387-ci5wx26t	342	4	-	-	HYPH
cord-018387-ci5wx26t	342	5	induced	induce	VBN
cord-018387-ci5wx26t	342	6	neurotoxicity	neurotoxicity	NN
cord-018387-ci5wx26t	342	7	through	through	IN
cord-018387-ci5wx26t	342	8	inhibiting	inhibit	VBG
cord-018387-ci5wx26t	342	9	microglial	microglial	JJ
cord-018387-ci5wx26t	342	10	activation	activation	NN
cord-018387-ci5wx26t	342	11	Long	long	JJ
cord-018387-ci5wx26t	342	12	-	-	HYPH
cord-018387-ci5wx26t	342	13	term	term	NN
cord-018387-ci5wx26t	342	14	dietary	dietary	JJ
cord-018387-ci5wx26t	342	15	supplementation	supplementation	NN
cord-018387-ci5wx26t	342	16	of	of	IN
cord-018387-ci5wx26t	342	17	pomegranates	pomegranate	NNS
cord-018387-ci5wx26t	342	18	,	,	,
cord-018387-ci5wx26t	342	19	figs	fig	NNS
cord-018387-ci5wx26t	342	20	and	and	CC
cord-018387-ci5wx26t	342	21	dates	date	NNS
cord-018387-ci5wx26t	343	1	alleviate	alleviate	VB
cord-018387-ci5wx26t	343	2	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	343	3	in	in	IN
cord-018387-ci5wx26t	343	4	a	a	DT
cord-018387-ci5wx26t	343	5	transgenic	transgenic	JJ
cord-018387-ci5wx26t	343	6	mouse	mouse	NN
cord-018387-ci5wx26t	343	7	model	model	NN
cord-018387-ci5wx26t	343	8	of	of	IN
cord-018387-ci5wx26t	343	9	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	343	10	's	's	POS
cord-018387-ci5wx26t	343	11	disease	disease	NN
cord-018387-ci5wx26t	343	12	Effect	effect	NN
cord-018387-ci5wx26t	343	13	of	of	IN
cord-018387-ci5wx26t	343	14	zinc	zinc	NN
cord-018387-ci5wx26t	343	15	supplementation	supplementation	NN
cord-018387-ci5wx26t	343	16	on	on	IN
cord-018387-ci5wx26t	343	17	serum	serum	NN
cord-018387-ci5wx26t	343	18	zinc	zinc	NN
cord-018387-ci5wx26t	343	19	concentration	concentration	NN
cord-018387-ci5wx26t	343	20	and	and	CC
cord-018387-ci5wx26t	343	21	T	t	NN
cord-018387-ci5wx26t	343	22	cell	cell	NN
cord-018387-ci5wx26t	343	23	proliferation	proliferation	NN
cord-018387-ci5wx26t	343	24	in	in	IN
cord-018387-ci5wx26t	343	25	nursing	nursing	NN
cord-018387-ci5wx26t	343	26	home	home	NN
cord-018387-ci5wx26t	343	27	elderly	elderly	JJ
cord-018387-ci5wx26t	343	28	:	:	:
cord-018387-ci5wx26t	343	29	a	a	DT
cord-018387-ci5wx26t	343	30	randomized	randomized	JJ
cord-018387-ci5wx26t	343	31	,	,	,
cord-018387-ci5wx26t	343	32	double	double	JJ
cord-018387-ci5wx26t	343	33	-	-	HYPH
cord-018387-ci5wx26t	343	34	blind	blind	JJ
cord-018387-ci5wx26t	343	35	,	,	,
cord-018387-ci5wx26t	343	36	placebo	placebo	NN
cord-018387-ci5wx26t	343	37	-	-	HYPH
cord-018387-ci5wx26t	343	38	controlled	control	VBN
cord-018387-ci5wx26t	343	39	trial	trial	NN
cord-018387-ci5wx26t	343	40	Zinc	zinc	NN
cord-018387-ci5wx26t	343	41	influences	influence	NNS
cord-018387-ci5wx26t	343	42	innate	innate	VBP
cord-018387-ci5wx26t	343	43	immune	immune	JJ
cord-018387-ci5wx26t	343	44	responses	response	NNS
cord-018387-ci5wx26t	343	45	in	in	IN
cord-018387-ci5wx26t	343	46	children	child	NNS
cord-018387-ci5wx26t	343	47	with	with	IN
cord-018387-ci5wx26t	343	48	enterotoxigenic	enterotoxigenic	NNP
cord-018387-ci5wx26t	343	49	Escherichia	Escherichia	NNP
cord-018387-ci5wx26t	343	50	coli	coli	NNS
cord-018387-ci5wx26t	343	51	-	-	HYPH
cord-018387-ci5wx26t	343	52	induced	induce	VBN
cord-018387-ci5wx26t	343	53	diarrhea	diarrhea	NN
cord-018387-ci5wx26t	343	54	Vitamin	vitamin	NN
cord-018387-ci5wx26t	343	55	C	c	NN
cord-018387-ci5wx26t	343	56	,	,	,
cord-018387-ci5wx26t	343	57	aging	age	VBG
cord-018387-ci5wx26t	343	58	and	and	CC
cord-018387-ci5wx26t	343	59	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	343	60	's	's	POS
cord-018387-ci5wx26t	343	61	disease	disease	NN
cord-018387-ci5wx26t	344	1	Vitamin	vitamin	NN
cord-018387-ci5wx26t	344	2	E	e	NN
cord-018387-ci5wx26t	344	3	supplementation	supplementation	NN
cord-018387-ci5wx26t	344	4	enhances	enhance	VBZ
cord-018387-ci5wx26t	344	5	cell	cell	NN
cord-018387-ci5wx26t	344	6	-	-	HYPH
cord-018387-ci5wx26t	344	7	mediated	mediate	VBN
cord-018387-ci5wx26t	344	8	immunity	immunity	NN
cord-018387-ci5wx26t	344	9	in	in	IN
cord-018387-ci5wx26t	344	10	healthy	healthy	JJ
cord-018387-ci5wx26t	344	11	elderly	elderly	JJ
cord-018387-ci5wx26t	344	12	subjects	subject	NNS
cord-018387-ci5wx26t	344	13	Vitamin	vitamin	NN
cord-018387-ci5wx26t	344	14	E	e	NN
cord-018387-ci5wx26t	344	15	,	,	,
cord-018387-ci5wx26t	344	16	signalosomes	signalosome	NNS
cord-018387-ci5wx26t	344	17	and	and	CC
cord-018387-ci5wx26t	344	18	gene	gene	NN
cord-018387-ci5wx26t	344	19	expression	expression	NN
cord-018387-ci5wx26t	344	20	in	in	IN
cord-018387-ci5wx26t	344	21	T	t	NN
cord-018387-ci5wx26t	344	22	cells	cell	NNS
cord-018387-ci5wx26t	344	23	Age	age	NN
cord-018387-ci5wx26t	344	24	-	-	HYPH
cord-018387-ci5wx26t	344	25	associated	associate	VBN
cord-018387-ci5wx26t	344	26	changes	change	NNS
cord-018387-ci5wx26t	344	27	in	in	IN
cord-018387-ci5wx26t	344	28	immune	immune	JJ
cord-018387-ci5wx26t	344	29	function	function	NN
cord-018387-ci5wx26t	344	30	:	:	:
cord-018387-ci5wx26t	344	31	impact	impact	NN
cord-018387-ci5wx26t	344	32	of	of	IN
cord-018387-ci5wx26t	344	33	vitamin	vitamin	NN
cord-018387-ci5wx26t	344	34	E	e	NN
cord-018387-ci5wx26t	344	35	intervention	intervention	NN
cord-018387-ci5wx26t	344	36	and	and	CC
cord-018387-ci5wx26t	344	37	the	the	DT
cord-018387-ci5wx26t	344	38	underlying	underlie	VBG
cord-018387-ci5wx26t	344	39	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	344	40	Eugenol	Eugenol	NNP
cord-018387-ci5wx26t	344	41	suppresses	suppress	VBZ
cord-018387-ci5wx26t	344	42	cyclooxygenase-2	cyclooxygenase-2	NNP
cord-018387-ci5wx26t	344	43	expression	expression	NN
cord-018387-ci5wx26t	344	44	in	in	IN
cord-018387-ci5wx26t	344	45	lipopolysaccharide	lipopolysaccharide	NN
cord-018387-ci5wx26t	344	46	-	-	HYPH
cord-018387-ci5wx26t	344	47	stimulated	stimulate	VBN
cord-018387-ci5wx26t	344	48	mouse	mouse	NN
cord-018387-ci5wx26t	344	49	macrophage	macrophage	NN
cord-018387-ci5wx26t	344	50	RAW264.7	RAW264.7	NNP
cord-018387-ci5wx26t	344	51	cells	cell	NNS
cord-018387-ci5wx26t	344	52	Effect	effect	NN
cord-018387-ci5wx26t	344	53	of	of	IN
cord-018387-ci5wx26t	344	54	6-gingerol	6-gingerol	CD
cord-018387-ci5wx26t	344	55	on	on	IN
cord-018387-ci5wx26t	344	56	pro	pro	JJ
cord-018387-ci5wx26t	344	57	-	-	JJ
cord-018387-ci5wx26t	344	58	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	344	59	cytokine	cytokine	NN
cord-018387-ci5wx26t	344	60	production	production	NN
cord-018387-ci5wx26t	344	61	and	and	CC
cord-018387-ci5wx26t	344	62	costimulatory	costimulatory	NNP
cord-018387-ci5wx26t	344	63	molecule	molecule	NN
cord-018387-ci5wx26t	344	64	expression	expression	NN
cord-018387-ci5wx26t	344	65	in	in	IN
cord-018387-ci5wx26t	344	66	murine	murine	JJ
cord-018387-ci5wx26t	344	67	peritoneal	peritoneal	JJ
cord-018387-ci5wx26t	344	68	macrophages	macrophage	NNS
cord-018387-ci5wx26t	344	69	Curcumin	Curcumin	NNP
cord-018387-ci5wx26t	344	70	(	(	-LRB-
cord-018387-ci5wx26t	344	71	diferuloylmethane	diferuloylmethane	NNP
cord-018387-ci5wx26t	344	72	)	)	-RRB-
cord-018387-ci5wx26t	344	73	down	down	RB
cord-018387-ci5wx26t	344	74	-	-	HYPH
cord-018387-ci5wx26t	344	75	regulates	regulate	VBZ
cord-018387-ci5wx26t	344	76	cigarette	cigarette	NN
cord-018387-ci5wx26t	344	77	smoke	smoke	NN
cord-018387-ci5wx26t	344	78	-	-	HYPH
cord-018387-ci5wx26t	344	79	induced	induce	VBN
cord-018387-ci5wx26t	344	80	NF	nf	NN
cord-018387-ci5wx26t	344	81	-	-	HYPH
cord-018387-ci5wx26t	344	82	kappaB	kappaB	NNP
cord-018387-ci5wx26t	344	83	activation	activation	NN
cord-018387-ci5wx26t	344	84	through	through	IN
cord-018387-ci5wx26t	344	85	inhibition	inhibition	NN
cord-018387-ci5wx26t	344	86	of	of	IN
cord-018387-ci5wx26t	344	87	IkappaBalpha	IkappaBalpha	NNP
cord-018387-ci5wx26t	344	88	kinase	kinase	NN
cord-018387-ci5wx26t	344	89	in	in	IN
cord-018387-ci5wx26t	344	90	human	human	JJ
cord-018387-ci5wx26t	344	91	lung	lung	NN
cord-018387-ci5wx26t	344	92	epithelial	epithelial	NN
cord-018387-ci5wx26t	344	93	cells	cell	NNS
cord-018387-ci5wx26t	344	94	:	:	:
cord-018387-ci5wx26t	344	95	correlation	correlation	NN
cord-018387-ci5wx26t	344	96	with	with	IN
cord-018387-ci5wx26t	344	97	suppression	suppression	NN
cord-018387-ci5wx26t	344	98	of	of	IN
cord-018387-ci5wx26t	344	99	COX-2	COX-2	NNP
cord-018387-ci5wx26t	344	100	,	,	,
cord-018387-ci5wx26t	344	101	MMP-9	MMP-9	NNP
cord-018387-ci5wx26t	344	102	and	and	CC
cord-018387-ci5wx26t	344	103	cyclin	cyclin	NN
cord-018387-ci5wx26t	345	1	D1	D1	NNP
cord-018387-ci5wx26t	345	2	Anethole	Anethole	NNP
cord-018387-ci5wx26t	345	3	blocks	block	VBZ
cord-018387-ci5wx26t	345	4	both	both	CC
cord-018387-ci5wx26t	345	5	early	early	JJ
cord-018387-ci5wx26t	345	6	and	and	CC
cord-018387-ci5wx26t	345	7	late	late	JJ
cord-018387-ci5wx26t	345	8	cellular	cellular	JJ
cord-018387-ci5wx26t	345	9	responses	response	NNS
cord-018387-ci5wx26t	345	10	transduced	transduce	VBN
cord-018387-ci5wx26t	345	11	by	by	IN
cord-018387-ci5wx26t	345	12	tumor	tumor	NN
cord-018387-ci5wx26t	345	13	necrosis	necrosis	NN
cord-018387-ci5wx26t	345	14	factor	factor	NN
cord-018387-ci5wx26t	345	15	:	:	:
cord-018387-ci5wx26t	345	16	effect	effect	NN
cord-018387-ci5wx26t	345	17	on	on	IN
cord-018387-ci5wx26t	345	18	NF	NF	NNP
cord-018387-ci5wx26t	345	19	-	-	HYPH
cord-018387-ci5wx26t	345	20	kappaB	kappaB	NNP
cord-018387-ci5wx26t	345	21	,	,	,
cord-018387-ci5wx26t	345	22	AP-1	AP-1	NNP
cord-018387-ci5wx26t	345	23	,	,	,
cord-018387-ci5wx26t	345	24	JNK	JNK	NNP
cord-018387-ci5wx26t	345	25	,	,	,
cord-018387-ci5wx26t	345	26	MAPKK	MAPKK	NNP
cord-018387-ci5wx26t	345	27	and	and	CC
cord-018387-ci5wx26t	345	28	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	345	29	Suppression	suppression	NN
cord-018387-ci5wx26t	345	30	of	of	IN
cord-018387-ci5wx26t	345	31	age	age	NN
cord-018387-ci5wx26t	345	32	-	-	HYPH
cord-018387-ci5wx26t	345	33	related	relate	VBN
cord-018387-ci5wx26t	345	34	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	345	35	NF	nf	NN
cord-018387-ci5wx26t	345	36	-	-	HYPH
cord-018387-ci5wx26t	345	37	kappaB	kappaB	NNP
cord-018387-ci5wx26t	345	38	activation	activation	NN
cord-018387-ci5wx26t	345	39	by	by	IN
cord-018387-ci5wx26t	345	40	cinnamaldehyde	cinnamaldehyde	NNP
cord-018387-ci5wx26t	345	41	Ursolic	Ursolic	NNP
cord-018387-ci5wx26t	345	42	acid	acid	NNP
cord-018387-ci5wx26t	346	1	inhibits	inhibit	VBZ
cord-018387-ci5wx26t	346	2	proliferation	proliferation	NN
cord-018387-ci5wx26t	346	3	and	and	CC
cord-018387-ci5wx26t	346	4	stimulates	stimulate	VBZ
cord-018387-ci5wx26t	346	5	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	346	6	in	in	IN
cord-018387-ci5wx26t	346	7	HT29	HT29	NNP
cord-018387-ci5wx26t	346	8	cells	cell	NNS
cord-018387-ci5wx26t	346	9	following	follow	VBG
cord-018387-ci5wx26t	346	10	activation	activation	NN
cord-018387-ci5wx26t	346	11	of	of	IN
cord-018387-ci5wx26t	346	12	alkaline	alkaline	JJ
cord-018387-ci5wx26t	346	13	sphingomyelinase	sphingomyelinase	NN
cord-018387-ci5wx26t	346	14	Inhibitory	inhibitory	JJ
cord-018387-ci5wx26t	346	15	effect	effect	NN
cord-018387-ci5wx26t	346	16	of	of	IN
cord-018387-ci5wx26t	346	17	ursolic	ursolic	JJ
cord-018387-ci5wx26t	346	18	acid	acid	NN
cord-018387-ci5wx26t	346	19	on	on	IN
cord-018387-ci5wx26t	346	20	B16	B16	NNP
cord-018387-ci5wx26t	346	21	proliferation	proliferation	NN
cord-018387-ci5wx26t	346	22	through	through	IN
cord-018387-ci5wx26t	346	23	cell	cell	NN
cord-018387-ci5wx26t	346	24	cycle	cycle	NN
cord-018387-ci5wx26t	346	25	arrest	arrest	NN
cord-018387-ci5wx26t	347	1	Proliferative	proliferative	JJ
cord-018387-ci5wx26t	347	2	inhibition	inhibition	NN
cord-018387-ci5wx26t	347	3	,	,	,
cord-018387-ci5wx26t	347	4	cell	cell	NN
cord-018387-ci5wx26t	347	5	-	-	HYPH
cord-018387-ci5wx26t	347	6	cycle	cycle	NN
cord-018387-ci5wx26t	347	7	dysregulation	dysregulation	NN
cord-018387-ci5wx26t	347	8	,	,	,
cord-018387-ci5wx26t	347	9	and	and	CC
cord-018387-ci5wx26t	347	10	induction	induction	NN
cord-018387-ci5wx26t	347	11	of	of	IN
cord-018387-ci5wx26t	347	12	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	347	13	by	by	IN
cord-018387-ci5wx26t	347	14	ursolic	ursolic	JJ
cord-018387-ci5wx26t	347	15	acid	acid	NN
cord-018387-ci5wx26t	347	16	in	in	IN
cord-018387-ci5wx26t	347	17	human	human	JJ
cord-018387-ci5wx26t	347	18	non	non	JJ
cord-018387-ci5wx26t	347	19	-	-	JJ
cord-018387-ci5wx26t	347	20	small	small	JJ
cord-018387-ci5wx26t	347	21	cell	cell	NN
cord-018387-ci5wx26t	347	22	lung	lung	NN
cord-018387-ci5wx26t	347	23	cancer	cancer	NN
cord-018387-ci5wx26t	347	24	A549	A549	NNP
cord-018387-ci5wx26t	347	25	cells	cell	NNS
cord-018387-ci5wx26t	348	1	Ursolic	Ursolic	NNP
cord-018387-ci5wx26t	348	2	acid	acid	NN
cord-018387-ci5wx26t	348	3	induces	induce	VBZ
cord-018387-ci5wx26t	348	4	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	348	5	through	through	IN
cord-018387-ci5wx26t	348	6	mitochondrial	mitochondrial	JJ
cord-018387-ci5wx26t	348	7	intrinsic	intrinsic	JJ
cord-018387-ci5wx26t	348	8	pathway	pathway	NN
cord-018387-ci5wx26t	348	9	and	and	CC
cord-018387-ci5wx26t	348	10	caspase-3	caspase-3	NNP
cord-018387-ci5wx26t	348	11	activation	activation	NN
cord-018387-ci5wx26t	348	12	in	in	IN
cord-018387-ci5wx26t	348	13	M4Beu	M4Beu	NNP
cord-018387-ci5wx26t	348	14	melanoma	melanoma	NN
cord-018387-ci5wx26t	348	15	cells	cell	NNS
cord-018387-ci5wx26t	349	1	Ursolic	Ursolic	NNP
cord-018387-ci5wx26t	349	2	acid	acid	NN
cord-018387-ci5wx26t	349	3	inhibits	inhibit	VBZ
cord-018387-ci5wx26t	349	4	STAT3	STAT3	NNP
cord-018387-ci5wx26t	349	5	activation	activation	NN
cord-018387-ci5wx26t	349	6	pathway	pathway	NN
cord-018387-ci5wx26t	349	7	leading	lead	VBG
cord-018387-ci5wx26t	349	8	to	to	IN
cord-018387-ci5wx26t	349	9	suppression	suppression	NN
cord-018387-ci5wx26t	349	10	of	of	IN
cord-018387-ci5wx26t	349	11	proliferation	proliferation	NN
cord-018387-ci5wx26t	349	12	and	and	CC
cord-018387-ci5wx26t	349	13	chemosensitization	chemosensitization	NN
cord-018387-ci5wx26t	349	14	of	of	IN
cord-018387-ci5wx26t	349	15	human	human	JJ
cord-018387-ci5wx26t	349	16	multiple	multiple	JJ
cord-018387-ci5wx26t	349	17	myeloma	myeloma	NN
cord-018387-ci5wx26t	349	18	cells	cell	NNS
cord-018387-ci5wx26t	349	19	Proteomic	Proteomic	NNP
cord-018387-ci5wx26t	349	20	analysis	analysis	NN
cord-018387-ci5wx26t	349	21	of	of	IN
cord-018387-ci5wx26t	349	22	ursolic	ursolic	JJ
cord-018387-ci5wx26t	349	23	acid	acid	NN
cord-018387-ci5wx26t	349	24	-	-	HYPH
cord-018387-ci5wx26t	349	25	induced	induce	VBN
cord-018387-ci5wx26t	349	26	apoptosis	apoptosis	NN
cord-018387-ci5wx26t	349	27	in	in	IN
cord-018387-ci5wx26t	349	28	cervical	cervical	JJ
cord-018387-ci5wx26t	349	29	carcinoma	carcinoma	NN
cord-018387-ci5wx26t	349	30	cells	cell	NNS
cord-018387-ci5wx26t	350	1	Are	be	VBP
cord-018387-ci5wx26t	350	2	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	350	3	strong	strong	JJ
cord-018387-ci5wx26t	350	4	dietary	dietary	JJ
cord-018387-ci5wx26t	350	5	agents	agent	NNS
cord-018387-ci5wx26t	350	6	against	against	IN
cord-018387-ci5wx26t	350	7	neurotoxicity	neurotoxicity	NN
cord-018387-ci5wx26t	350	8	and	and	CC
cord-018387-ci5wx26t	350	9	neurodegeneration	neurodegeneration	NN
cord-018387-ci5wx26t	350	10	?	?	.
cord-018387-ci5wx26t	351	1	Nutrients	nutrient	NNS
cord-018387-ci5wx26t	351	2	,	,	,
cord-018387-ci5wx26t	351	3	microglia	microglia	NN
cord-018387-ci5wx26t	351	4	aging	age	VBG
cord-018387-ci5wx26t	351	5	,	,	,
cord-018387-ci5wx26t	351	6	and	and	CC
cord-018387-ci5wx26t	351	7	brain	brain	NN
cord-018387-ci5wx26t	351	8	aging	age	VBG
cord-018387-ci5wx26t	351	9	A	a	DT
cord-018387-ci5wx26t	351	10	dietary	dietary	JJ
cord-018387-ci5wx26t	351	11	treatment	treatment	NN
cord-018387-ci5wx26t	351	12	improves	improve	VBZ
cord-018387-ci5wx26t	351	13	cerebral	cerebral	JJ
cord-018387-ci5wx26t	351	14	blood	blood	NN
cord-018387-ci5wx26t	351	15	flow	flow	NN
cord-018387-ci5wx26t	351	16	and	and	CC
cord-018387-ci5wx26t	351	17	brain	brain	NN
cord-018387-ci5wx26t	351	18	connectivity	connectivity	NN
cord-018387-ci5wx26t	351	19	in	in	IN
cord-018387-ci5wx26t	351	20	aging	age	VBG
cord-018387-ci5wx26t	351	21	apoE4	apoe4	DT
cord-018387-ci5wx26t	351	22	mice	mice	NN
cord-018387-ci5wx26t	352	1	Luteolin	Luteolin	NNP
cord-018387-ci5wx26t	352	2	reduces	reduce	VBZ
cord-018387-ci5wx26t	352	3	IL-6	IL-6	NNP
cord-018387-ci5wx26t	352	4	production	production	NN
cord-018387-ci5wx26t	352	5	in	in	IN
cord-018387-ci5wx26t	352	6	microglia	microglia	NNS
cord-018387-ci5wx26t	352	7	by	by	IN
cord-018387-ci5wx26t	352	8	inhibiting	inhibit	VBG
cord-018387-ci5wx26t	352	9	JNK	JNK	NNP
cord-018387-ci5wx26t	352	10	phosphorylation	phosphorylation	NN
cord-018387-ci5wx26t	352	11	and	and	CC
cord-018387-ci5wx26t	352	12	activation	activation	NN
cord-018387-ci5wx26t	352	13	of	of	IN
cord-018387-ci5wx26t	352	14	AP-1	AP-1	NNP
cord-018387-ci5wx26t	352	15	Dietary	dietary	JJ
cord-018387-ci5wx26t	352	16	luteolin	luteolin	NN
cord-018387-ci5wx26t	353	1	reduces	reduce	VBZ
cord-018387-ci5wx26t	353	2	proinflammatory	proinflammatory	JJ
cord-018387-ci5wx26t	353	3	microglia	microglia	NNS
cord-018387-ci5wx26t	353	4	in	in	IN
cord-018387-ci5wx26t	353	5	the	the	DT
cord-018387-ci5wx26t	353	6	brain	brain	NN
cord-018387-ci5wx26t	353	7	of	of	IN
cord-018387-ci5wx26t	353	8	senescent	senescent	JJ
cord-018387-ci5wx26t	353	9	mice	mouse	NNS
cord-018387-ci5wx26t	354	1	The	the	DT
cord-018387-ci5wx26t	354	2	Neuroprotective	Neuroprotective	NNP
cord-018387-ci5wx26t	354	3	effects	effect	NNS
cord-018387-ci5wx26t	354	4	of	of	IN
cord-018387-ci5wx26t	354	5	phenolic	phenolic	JJ
cord-018387-ci5wx26t	354	6	acids	acid	NNS
cord-018387-ci5wx26t	354	7	:	:	:
cord-018387-ci5wx26t	354	8	molecular	molecular	JJ
cord-018387-ci5wx26t	354	9	mechanism	mechanism	NN
cord-018387-ci5wx26t	354	10	of	of	IN
cord-018387-ci5wx26t	354	11	action	action	NN
cord-018387-ci5wx26t	354	12	Molecular	molecular	JJ
cord-018387-ci5wx26t	354	13	antiinflammatory	antiinflammatory	JJ
cord-018387-ci5wx26t	354	14	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	354	15	of	of	IN
cord-018387-ci5wx26t	354	16	retinoids	retinoid	NNS
cord-018387-ci5wx26t	354	17	and	and	CC
cord-018387-ci5wx26t	354	18	carotenoids	carotenoid	NNS
cord-018387-ci5wx26t	354	19	in	in	IN
cord-018387-ci5wx26t	354	20	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	354	21	's	's	POS
cord-018387-ci5wx26t	354	22	disease	disease	NN
cord-018387-ci5wx26t	354	23	:	:	:
cord-018387-ci5wx26t	354	24	a	a	DT
cord-018387-ci5wx26t	354	25	review	review	NN
cord-018387-ci5wx26t	354	26	of	of	IN
cord-018387-ci5wx26t	354	27	current	current	JJ
cord-018387-ci5wx26t	354	28	evidence	evidence	NN
cord-018387-ci5wx26t	354	29	Sesamol	Sesamol	NNP
cord-018387-ci5wx26t	354	30	supplementation	supplementation	NN
cord-018387-ci5wx26t	354	31	prevents	prevent	VBZ
cord-018387-ci5wx26t	354	32	systemic	systemic	JJ
cord-018387-ci5wx26t	354	33	inflammation	inflammation	NN
cord-018387-ci5wx26t	354	34	-	-	HYPH
cord-018387-ci5wx26t	354	35	induced	induce	VBN
cord-018387-ci5wx26t	354	36	memory	memory	NN
cord-018387-ci5wx26t	354	37	impairment	impairment	NN
cord-018387-ci5wx26t	354	38	and	and	CC
cord-018387-ci5wx26t	354	39	amyloidogenesis	amyloidogenesis	NN
cord-018387-ci5wx26t	354	40	via	via	IN
cord-018387-ci5wx26t	354	41	inhibition	inhibition	NN
cord-018387-ci5wx26t	354	42	of	of	IN
cord-018387-ci5wx26t	354	43	nuclear	nuclear	JJ
cord-018387-ci5wx26t	354	44	factor	factor	NN
cord-018387-ci5wx26t	354	45	kappaB	kappaB	NNP
cord-018387-ci5wx26t	354	46	Nutrition	Nutrition	NNP
cord-018387-ci5wx26t	354	47	for	for	IN
cord-018387-ci5wx26t	354	48	the	the	DT
cord-018387-ci5wx26t	354	49	ageing	age	VBG
cord-018387-ci5wx26t	354	50	brain	brain	NN
cord-018387-ci5wx26t	354	51	:	:	:
cord-018387-ci5wx26t	354	52	towards	towards	IN
cord-018387-ci5wx26t	354	53	evidence	evidence	NN
cord-018387-ci5wx26t	354	54	for	for	IN
cord-018387-ci5wx26t	354	55	an	an	DT
cord-018387-ci5wx26t	354	56	optimal	optimal	JJ
cord-018387-ci5wx26t	354	57	diet	diet	NN
cord-018387-ci5wx26t	354	58	Neuroinflammatory	neuroinflammatory	NN
cord-018387-ci5wx26t	354	59	processes	process	NNS
cord-018387-ci5wx26t	354	60	in	in	IN
cord-018387-ci5wx26t	354	61	cognitive	cognitive	JJ
cord-018387-ci5wx26t	354	62	disorders	disorder	NNS
cord-018387-ci5wx26t	354	63	:	:	:
cord-018387-ci5wx26t	354	64	is	be	VBZ
cord-018387-ci5wx26t	354	65	there	there	EX
cord-018387-ci5wx26t	354	66	a	a	DT
cord-018387-ci5wx26t	354	67	role	role	NN
cord-018387-ci5wx26t	354	68	for	for	IN
cord-018387-ci5wx26t	354	69	flavonoids	flavonoid	NNS
cord-018387-ci5wx26t	354	70	and	and	CC
cord-018387-ci5wx26t	354	71	n-3	n-3	JJ
cord-018387-ci5wx26t	354	72	polyunsaturated	polyunsaturated	JJ
cord-018387-ci5wx26t	354	73	fatty	fatty	JJ
cord-018387-ci5wx26t	354	74	acids	acid	NNS
cord-018387-ci5wx26t	354	75	in	in	IN
cord-018387-ci5wx26t	354	76	counteracting	counteract	VBG
cord-018387-ci5wx26t	354	77	their	-PRON-	PRP$
cord-018387-ci5wx26t	354	78	detrimental	detrimental	JJ
cord-018387-ci5wx26t	354	79	effects	effect	NNS
cord-018387-ci5wx26t	354	80	?	?	.
cord-018387-ci5wx26t	355	1	The	the	DT
cord-018387-ci5wx26t	355	2	role	role	NN
cord-018387-ci5wx26t	355	3	for	for	IN
cord-018387-ci5wx26t	355	4	dietary	dietary	JJ
cord-018387-ci5wx26t	355	5	omega-3	omega-3	NN
cord-018387-ci5wx26t	355	6	fatty	fatty	JJ
cord-018387-ci5wx26t	355	7	acids	acid	NNS
cord-018387-ci5wx26t	355	8	supplementation	supplementation	NN
cord-018387-ci5wx26t	355	9	in	in	IN
cord-018387-ci5wx26t	355	10	older	old	JJR
cord-018387-ci5wx26t	355	11	adults	adult	NNS
cord-018387-ci5wx26t	355	12	Omega-3	omega-3	VBP
cord-018387-ci5wx26t	355	13	polyunsaturated	polyunsaturated	JJ
cord-018387-ci5wx26t	355	14	fatty	fatty	JJ
cord-018387-ci5wx26t	355	15	acids	acid	NNS
cord-018387-ci5wx26t	355	16	and	and	CC
cord-018387-ci5wx26t	355	17	oxylipins	oxylipin	NNS
cord-018387-ci5wx26t	355	18	in	in	IN
cord-018387-ci5wx26t	355	19	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	355	20	and	and	CC
cord-018387-ci5wx26t	355	21	management	management	NN
cord-018387-ci5wx26t	355	22	of	of	IN
cord-018387-ci5wx26t	355	23	Alzheimer	Alzheimer	NNP
cord-018387-ci5wx26t	355	24	disease	disease	NN
cord-018387-ci5wx26t	355	25	Dietary	dietary	JJ
cord-018387-ci5wx26t	355	26	eicosapentaenoic	eicosapentaenoic	JJ
cord-018387-ci5wx26t	355	27	acid	acid	NN
cord-018387-ci5wx26t	355	28	normalizes	normalize	VBZ
cord-018387-ci5wx26t	355	29	hippocampal	hippocampal	JJ
cord-018387-ci5wx26t	355	30	omega-3	omega-3	NN
cord-018387-ci5wx26t	355	31	and	and	CC
cord-018387-ci5wx26t	355	32	6	6	CD
cord-018387-ci5wx26t	355	33	polyunsaturated	polyunsaturated	JJ
cord-018387-ci5wx26t	355	34	fatty	fatty	JJ
cord-018387-ci5wx26t	355	35	acid	acid	NN
cord-018387-ci5wx26t	355	36	profile	profile	NN
cord-018387-ci5wx26t	355	37	,	,	,
cord-018387-ci5wx26t	355	38	attenuates	attenuate	VBZ
cord-018387-ci5wx26t	355	39	glial	glial	JJ
cord-018387-ci5wx26t	355	40	activation	activation	NN
cord-018387-ci5wx26t	355	41	and	and	CC
cord-018387-ci5wx26t	355	42	regulates	regulate	VBZ
cord-018387-ci5wx26t	355	43	BDNF	BDNF	NNP
cord-018387-ci5wx26t	355	44	function	function	NN
cord-018387-ci5wx26t	355	45	in	in	IN
cord-018387-ci5wx26t	355	46	a	a	DT
cord-018387-ci5wx26t	355	47	rodent	rodent	NN
cord-018387-ci5wx26t	355	48	model	model	NN
cord-018387-ci5wx26t	355	49	of	of	IN
cord-018387-ci5wx26t	355	50	neuroinflammation	neuroinflammation	NN
cord-018387-ci5wx26t	355	51	induced	induce	VBN
cord-018387-ci5wx26t	355	52	by	by	IN
cord-018387-ci5wx26t	355	53	central	central	JJ
cord-018387-ci5wx26t	355	54	interleukin-1beta	interleukin-1beta	JJ
cord-018387-ci5wx26t	355	55	administration	administration	NN
cord-018387-ci5wx26t	355	56	Docosahexaenoic	Docosahexaenoic	NNP
cord-018387-ci5wx26t	355	57	acid	acid	NN
cord-018387-ci5wx26t	355	58	(	(	-LRB-
cord-018387-ci5wx26t	355	59	DHA	DHA	NNP
cord-018387-ci5wx26t	355	60	)	)	-RRB-
cord-018387-ci5wx26t	355	61	:	:	:
cord-018387-ci5wx26t	355	62	an	an	DT
cord-018387-ci5wx26t	355	63	essential	essential	JJ
cord-018387-ci5wx26t	355	64	nutrient	nutrient	NN
cord-018387-ci5wx26t	355	65	and	and	CC
cord-018387-ci5wx26t	355	66	a	a	DT
cord-018387-ci5wx26t	355	67	nutraceutical	nutraceutical	NN
cord-018387-ci5wx26t	355	68	for	for	IN
cord-018387-ci5wx26t	355	69	brain	brain	NN
cord-018387-ci5wx26t	355	70	health	health	NN
cord-018387-ci5wx26t	355	71	and	and	CC
cord-018387-ci5wx26t	355	72	diseases	disease	NNS
cord-018387-ci5wx26t	355	73	Physical	physical	JJ
cord-018387-ci5wx26t	355	74	activity	activity	NN
cord-018387-ci5wx26t	355	75	and	and	CC
cord-018387-ci5wx26t	355	76	cognitive	cognitive	JJ
cord-018387-ci5wx26t	355	77	function	function	NN
cord-018387-ci5wx26t	355	78	in	in	IN
cord-018387-ci5wx26t	355	79	individuals	individual	NNS
cord-018387-ci5wx26t	355	80	over	over	IN
cord-018387-ci5wx26t	355	81	60	60	CD
cord-018387-ci5wx26t	355	82	years	year	NNS
cord-018387-ci5wx26t	355	83	of	of	IN
cord-018387-ci5wx26t	355	84	age	age	NN
cord-018387-ci5wx26t	355	85	:	:	:
cord-018387-ci5wx26t	355	86	a	a	DT
cord-018387-ci5wx26t	355	87	systematic	systematic	JJ
cord-018387-ci5wx26t	355	88	review	review	NN
cord-018387-ci5wx26t	355	89	Physical	physical	JJ
cord-018387-ci5wx26t	355	90	exercise	exercise	NN
cord-018387-ci5wx26t	355	91	and	and	CC
cord-018387-ci5wx26t	355	92	cognitive	cognitive	JJ
cord-018387-ci5wx26t	355	93	performance	performance	NN
cord-018387-ci5wx26t	355	94	in	in	IN
cord-018387-ci5wx26t	355	95	the	the	DT
cord-018387-ci5wx26t	355	96	elderly	elderly	JJ
cord-018387-ci5wx26t	355	97	:	:	:
cord-018387-ci5wx26t	355	98	current	current	JJ
cord-018387-ci5wx26t	355	99	perspectives	perspective	NNS
cord-018387-ci5wx26t	355	100	Exercising	exercise	VBG
cord-018387-ci5wx26t	355	101	the	the	DT
cord-018387-ci5wx26t	355	102	worry	worry	NN
cord-018387-ci5wx26t	355	103	away	away	RB
cord-018387-ci5wx26t	355	104	:	:	:
cord-018387-ci5wx26t	356	1	how	how	WRB
cord-018387-ci5wx26t	356	2	inflammation	inflammation	NN
cord-018387-ci5wx26t	356	3	,	,	,
cord-018387-ci5wx26t	356	4	oxidative	oxidative	JJ
cord-018387-ci5wx26t	356	5	and	and	CC
cord-018387-ci5wx26t	356	6	nitrogen	nitrogen	NN
cord-018387-ci5wx26t	356	7	stress	stress	NN
cord-018387-ci5wx26t	356	8	mediates	mediate	VBZ
cord-018387-ci5wx26t	356	9	the	the	DT
cord-018387-ci5wx26t	356	10	beneficial	beneficial	JJ
cord-018387-ci5wx26t	356	11	effect	effect	NN
cord-018387-ci5wx26t	356	12	of	of	IN
cord-018387-ci5wx26t	356	13	physical	physical	JJ
cord-018387-ci5wx26t	356	14	activity	activity	NN
cord-018387-ci5wx26t	356	15	on	on	IN
cord-018387-ci5wx26t	356	16	anxiety	anxiety	NN
cord-018387-ci5wx26t	356	17	disorder	disorder	NN
cord-018387-ci5wx26t	356	18	symptoms	symptom	NNS
cord-018387-ci5wx26t	356	19	and	and	CC
cord-018387-ci5wx26t	356	20	behaviours	behaviour	NNS
cord-018387-ci5wx26t	357	1	Little	little	JJ
cord-018387-ci5wx26t	357	2	exercise	exercise	NN
cord-018387-ci5wx26t	357	3	,	,	,
cord-018387-ci5wx26t	357	4	big	big	JJ
cord-018387-ci5wx26t	357	5	effects	effect	NNS
cord-018387-ci5wx26t	357	6	:	:	:
cord-018387-ci5wx26t	358	1	reversing	reverse	VBG
cord-018387-ci5wx26t	358	2	aging	aging	NN
cord-018387-ci5wx26t	358	3	and	and	CC
cord-018387-ci5wx26t	358	4	infection	infection	NN
cord-018387-ci5wx26t	358	5	-	-	HYPH
cord-018387-ci5wx26t	358	6	induced	induce	VBN
cord-018387-ci5wx26t	358	7	memory	memory	NN
cord-018387-ci5wx26t	358	8	deficits	deficit	NNS
cord-018387-ci5wx26t	358	9	,	,	,
cord-018387-ci5wx26t	358	10	and	and	CC
cord-018387-ci5wx26t	358	11	underlying	underlying	JJ
cord-018387-ci5wx26t	358	12	processes	process	NNS
cord-018387-ci5wx26t	359	1	Wheel	wheel	NN
cord-018387-ci5wx26t	359	2	running	running	NN
cord-018387-ci5wx26t	359	3	attenuates	attenuate	VBZ
cord-018387-ci5wx26t	359	4	microglia	microglia	JJ
cord-018387-ci5wx26t	359	5	proliferation	proliferation	NN
cord-018387-ci5wx26t	359	6	and	and	CC
cord-018387-ci5wx26t	359	7	increases	increase	VBZ
cord-018387-ci5wx26t	359	8	expression	expression	NN
cord-018387-ci5wx26t	359	9	of	of	IN
cord-018387-ci5wx26t	359	10	a	a	DT
cord-018387-ci5wx26t	359	11	proneurogenic	proneurogenic	JJ
cord-018387-ci5wx26t	359	12	phenotype	phenotype	NN
cord-018387-ci5wx26t	359	13	in	in	IN
cord-018387-ci5wx26t	359	14	the	the	DT
cord-018387-ci5wx26t	359	15	hippocampus	hippocampus	NN
cord-018387-ci5wx26t	359	16	of	of	IN
cord-018387-ci5wx26t	359	17	aged	aged	JJ
cord-018387-ci5wx26t	359	18	mice	mouse	NNS
cord-018387-ci5wx26t	359	19	Physical	physical	JJ
cord-018387-ci5wx26t	359	20	activity	activity	NN
cord-018387-ci5wx26t	359	21	and	and	CC
cord-018387-ci5wx26t	359	22	high	high	JJ
cord-018387-ci5wx26t	359	23	-	-	HYPH
cord-018387-ci5wx26t	359	24	sensitivity	sensitivity	NN
cord-018387-ci5wx26t	359	25	C	c	NN
cord-018387-ci5wx26t	359	26	-	-	HYPH
cord-018387-ci5wx26t	359	27	reactive	reactive	JJ
cord-018387-ci5wx26t	359	28	protein	protein	NN
cord-018387-ci5wx26t	359	29	the	the	DT
cord-018387-ci5wx26t	359	30	multi	multi	JJ
cord-018387-ci5wx26t	359	31	-	-	JJ
cord-018387-ci5wx26t	359	32	ethnic	ethnic	JJ
cord-018387-ci5wx26t	359	33	study	study	NN
cord-018387-ci5wx26t	359	34	of	of	IN
cord-018387-ci5wx26t	359	35	atherosclerosis	atherosclerosis	NN
cord-018387-ci5wx26t	359	36	Exercise	exercise	NN
cord-018387-ci5wx26t	359	37	-	-	HYPH
cord-018387-ci5wx26t	359	38	induced	induce	VBN
cord-018387-ci5wx26t	359	39	myokines	myokine	NNS
cord-018387-ci5wx26t	359	40	and	and	CC
cord-018387-ci5wx26t	359	41	their	-PRON-	PRP$
cord-018387-ci5wx26t	359	42	role	role	NN
cord-018387-ci5wx26t	359	43	in	in	IN
cord-018387-ci5wx26t	359	44	chronic	chronic	JJ
cord-018387-ci5wx26t	359	45	diseases	disease	NNS
cord-018387-ci5wx26t	360	1	Exercise	exercise	NN
cord-018387-ci5wx26t	360	2	training	training	NN
cord-018387-ci5wx26t	360	3	-	-	HYPH
cord-018387-ci5wx26t	360	4	induced	induce	VBN
cord-018387-ci5wx26t	360	5	lowering	lowering	NN
cord-018387-ci5wx26t	360	6	of	of	IN
cord-018387-ci5wx26t	360	7	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	360	8	(	(	-LRB-
cord-018387-ci5wx26t	360	9	CD14+CD16	CD14+CD16	NNP
cord-018387-ci5wx26t	360	10	+	+	SYM
cord-018387-ci5wx26t	360	11	)	)	-RRB-
cord-018387-ci5wx26t	360	12	monocytes	monocyte	VBZ
cord-018387-ci5wx26t	360	13	:	:	:
cord-018387-ci5wx26t	360	14	a	a	DT
cord-018387-ci5wx26t	360	15	role	role	NN
cord-018387-ci5wx26t	360	16	in	in	IN
cord-018387-ci5wx26t	360	17	the	the	DT
cord-018387-ci5wx26t	360	18	anti	anti	JJ
cord-018387-ci5wx26t	360	19	-	-	JJ
cord-018387-ci5wx26t	360	20	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	360	21	influence	influence	NN
cord-018387-ci5wx26t	360	22	of	of	IN
cord-018387-ci5wx26t	360	23	exercise	exercise	NN
cord-018387-ci5wx26t	360	24	?	?	.
cord-018387-ci5wx26t	361	1	Deletion	deletion	NN
cord-018387-ci5wx26t	361	2	of	of	IN
cord-018387-ci5wx26t	361	3	the	the	DT
cord-018387-ci5wx26t	361	4	type-1	type-1	NN
cord-018387-ci5wx26t	361	5	interferon	interferon	NN
cord-018387-ci5wx26t	361	6	receptor	receptor	NN
cord-018387-ci5wx26t	361	7	in	in	IN
cord-018387-ci5wx26t	361	8	APPSWE	APPSWE	NNP
cord-018387-ci5wx26t	361	9	/	/	SYM
cord-018387-ci5wx26t	361	10	PS1DeltaE9	ps1deltae9	JJ
cord-018387-ci5wx26t	361	11	mice	mouse	NNS
cord-018387-ci5wx26t	361	12	preserves	preserve	VBZ
cord-018387-ci5wx26t	361	13	cognitive	cognitive	JJ
cord-018387-ci5wx26t	361	14	function	function	NN
cord-018387-ci5wx26t	361	15	and	and	CC
cord-018387-ci5wx26t	361	16	alters	alter	VBZ
cord-018387-ci5wx26t	361	17	glial	glial	JJ
cord-018387-ci5wx26t	361	18	phenotype	phenotype	NN
cord-018387-ci5wx26t	361	19	Exercise	exercise	NN
cord-018387-ci5wx26t	361	20	and	and	CC
cord-018387-ci5wx26t	361	21	the	the	DT
cord-018387-ci5wx26t	361	22	immune	immune	JJ
cord-018387-ci5wx26t	361	23	system	system	NN
cord-018387-ci5wx26t	361	24	:	:	:
cord-018387-ci5wx26t	361	25	regulation	regulation	NN
cord-018387-ci5wx26t	361	26	,	,	,
cord-018387-ci5wx26t	361	27	integration	integration	NN
cord-018387-ci5wx26t	361	28	,	,	,
cord-018387-ci5wx26t	361	29	and	and	CC
cord-018387-ci5wx26t	361	30	adaptation	adaptation	NN
cord-018387-ci5wx26t	361	31	The	the	DT
cord-018387-ci5wx26t	361	32	anti	anti	JJ
cord-018387-ci5wx26t	361	33	-	-	JJ
cord-018387-ci5wx26t	361	34	inflammatory	inflammatory	JJ
cord-018387-ci5wx26t	361	35	effect	effect	NN
cord-018387-ci5wx26t	361	36	of	of	IN
cord-018387-ci5wx26t	361	37	exercise	exercise	NN
cord-018387-ci5wx26t	361	38	Neuroprotective	Neuroprotective	NNP
cord-018387-ci5wx26t	361	39	effects	effect	NNS
cord-018387-ci5wx26t	361	40	of	of	IN
cord-018387-ci5wx26t	361	41	physical	physical	JJ
cord-018387-ci5wx26t	361	42	activity	activity	NN
cord-018387-ci5wx26t	361	43	on	on	IN
cord-018387-ci5wx26t	361	44	the	the	DT
cord-018387-ci5wx26t	361	45	brain	brain	NN
cord-018387-ci5wx26t	361	46	:	:	:
cord-018387-ci5wx26t	361	47	a	a	DT
cord-018387-ci5wx26t	361	48	closer	close	JJR
cord-018387-ci5wx26t	361	49	look	look	NN
cord-018387-ci5wx26t	361	50	at	at	IN
cord-018387-ci5wx26t	361	51	trophic	trophic	NN
cord-018387-ci5wx26t	361	52	factor	factor	NN
cord-018387-ci5wx26t	361	53	signaling	signal	VBG
cord-018387-ci5wx26t	361	54	Aging	aging	NN
cord-018387-ci5wx26t	361	55	and	and	CC
cord-018387-ci5wx26t	361	56	inflammation	inflammation	NN
cord-018387-ci5wx26t	361	57	:	:	:
cord-018387-ci5wx26t	361	58	directing	direct	VBG
cord-018387-ci5wx26t	361	59	traffic	traffic	NN
cord-018387-ci5wx26t	361	60	through	through	IN
cord-018387-ci5wx26t	361	61	physical	physical	JJ
cord-018387-ci5wx26t	361	62	activity	activity	NN
cord-018387-ci5wx26t	362	1	Reversing	reverse	VBG
cord-018387-ci5wx26t	362	2	age	age	NN
cord-018387-ci5wx26t	362	3	-	-	HYPH
cord-018387-ci5wx26t	362	4	associated	associate	VBN
cord-018387-ci5wx26t	362	5	immunosenescence	immunosenescence	RB
cord-018387-ci5wx26t	362	6	via	via	IN
cord-018387-ci5wx26t	362	7	exercise	exercise	NN
cord-018387-ci5wx26t	363	1	It	-PRON-	PRP
cord-018387-ci5wx26t	363	2	's	be	VBZ
cord-018387-ci5wx26t	363	3	never	never	RB
cord-018387-ci5wx26t	363	4	too	too	RB
cord-018387-ci5wx26t	363	5	late	late	JJ
cord-018387-ci5wx26t	363	6	Human	human	JJ
cord-018387-ci5wx26t	363	7	cognitive	cognitive	JJ
cord-018387-ci5wx26t	363	8	aging	aging	NN
cord-018387-ci5wx26t	363	9	:	:	:
cord-018387-ci5wx26t	363	10	corriger	corriger	NNP
cord-018387-ci5wx26t	363	11	la	la	NNP
cord-018387-ci5wx26t	363	12	fortune	fortune	NN
cord-018387-ci5wx26t	363	13	?	?	.
cord-018387-ci5wx26t	364	1	Leisure	leisure	NN
cord-018387-ci5wx26t	364	2	-	-	HYPH
cord-018387-ci5wx26t	364	3	time	time	NN
cord-018387-ci5wx26t	364	4	physical	physical	JJ
cord-018387-ci5wx26t	364	5	activity	activity	NN
cord-018387-ci5wx26t	364	6	from	from	IN
cord-018387-ci5wx26t	364	7	mid	mid	NN
cord-018387-ci5wx26t	364	8	-	-	NN
cord-018387-ci5wx26t	364	9	to	to	IN
cord-018387-ci5wx26t	364	10	late	late	JJ
cord-018387-ci5wx26t	364	11	life	life	NN
cord-018387-ci5wx26t	364	12	,	,	,
cord-018387-ci5wx26t	364	13	body	body	NN
cord-018387-ci5wx26t	364	14	mass	mass	NN
cord-018387-ci5wx26t	364	15	index	index	NN
cord-018387-ci5wx26t	364	16	,	,	,
cord-018387-ci5wx26t	364	17	and	and	CC
cord-018387-ci5wx26t	364	18	risk	risk	NN
cord-018387-ci5wx26t	364	19	of	of	IN
cord-018387-ci5wx26t	364	20	dementia	dementia	NN
cord-018387-ci5wx26t	364	21	Neurological	neurological	JJ
cord-018387-ci5wx26t	364	22	effects	effect	NNS
cord-018387-ci5wx26t	364	23	of	of	IN
cord-018387-ci5wx26t	364	24	honey	honey	NN
cord-018387-ci5wx26t	364	25	:	:	:
cord-018387-ci5wx26t	364	26	current	current	JJ
cord-018387-ci5wx26t	364	27	and	and	CC
cord-018387-ci5wx26t	364	28	future	future	JJ
cord-018387-ci5wx26t	364	29	prospects	prospect	NNS
cord-018387-ci5wx26t	365	1	The	the	DT
cord-018387-ci5wx26t	365	2	combination	combination	NN
cord-018387-ci5wx26t	365	3	of	of	IN
cord-018387-ci5wx26t	365	4	vitamins	vitamin	NNS
cord-018387-ci5wx26t	365	5	and	and	CC
cord-018387-ci5wx26t	365	6	omega-3	omega-3	JJ
cord-018387-ci5wx26t	365	7	fatty	fatty	JJ
cord-018387-ci5wx26t	365	8	acids	acid	NNS
cord-018387-ci5wx26t	365	9	has	have	VBZ
cord-018387-ci5wx26t	365	10	an	an	DT
cord-018387-ci5wx26t	365	11	enhanced	enhance	VBN
cord-018387-ci5wx26t	365	12	antiinflammatory	antiinflammatory	JJ
cord-018387-ci5wx26t	365	13	effect	effect	NN
cord-018387-ci5wx26t	365	14	on	on	IN
cord-018387-ci5wx26t	365	15	microglia	microglia	JJ
cord-018387-ci5wx26t	365	16	Dietary	dietary	JJ
cord-018387-ci5wx26t	365	17	polyphenols	polyphenol	NNS
cord-018387-ci5wx26t	365	18	as	as	IN
cord-018387-ci5wx26t	365	19	modulators	modulator	NNS
cord-018387-ci5wx26t	365	20	of	of	IN
cord-018387-ci5wx26t	365	21	brain	brain	NN
cord-018387-ci5wx26t	365	22	functions	function	NNS
cord-018387-ci5wx26t	365	23	:	:	:
cord-018387-ci5wx26t	365	24	biological	biological	JJ
cord-018387-ci5wx26t	365	25	actions	action	NNS
cord-018387-ci5wx26t	365	26	and	and	CC
cord-018387-ci5wx26t	365	27	molecular	molecular	JJ
cord-018387-ci5wx26t	365	28	mechanisms	mechanism	NNS
cord-018387-ci5wx26t	365	29	underpinning	underpin	VBG
cord-018387-ci5wx26t	365	30	their	-PRON-	PRP$
cord-018387-ci5wx26t	365	31	beneficial	beneficial	JJ
cord-018387-ci5wx26t	365	32	effects	effect	NNS
cord-018387-ci5wx26t	366	1	Acknowledgment	acknowledgment	NN
cord-018387-ci5wx26t	367	1	This	this	DT
cord-018387-ci5wx26t	367	2	research	research	NN
cord-018387-ci5wx26t	367	3	was	be	VBD
cord-018387-ci5wx26t	367	4	supported	support	VBN
cord-018387-ci5wx26t	367	5	by	by	IN
cord-018387-ci5wx26t	367	6	the	the	DT
cord-018387-ci5wx26t	367	7	Max	Max	NNP
cord-018387-ci5wx26t	367	8	Planck	Planck	NNP
cord-018387-ci5wx26t	367	9	Society	Society	NNP
cord-018387-ci5wx26t	367	10	.	.	.