id author title date pages extension mime words sentences flesch summary cache txt cord-354130-mi7saerx Compton, Susan R. Microbiological Monitoring in Individually Ventilated Cage Systems 2004 .txt text/plain 4406 183 46 The limitations of molecular methods are that they are relatively expensive, they can yield both false negative and false positive results, their high sensitivity makes them prone to cross-contamination, and many substances found in blood, feces, and other animal tissues can function Methods such as exposing sentinels to soiled bedding, as used traditionally with mice housed in static isolator cages, also require reassessment for their applicability in IVC systems. There are many ways of detecting an infectious agent that has been transmitted to one or more rodents housed in IVCs. The most direct method of surveillance is to monitor the colony mice themselves for evidence of an infection. The decreased intercage spread of an infectious agent means that infections are sporadic and confined to just a few cages at a time, and it is therefore essential to use an adequate sample size when monitoring mice housed in IVC systems. ./cache/cord-354130-mi7saerx.txt ./txt/cord-354130-mi7saerx.txt